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Search of human proteins with 167555125
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|167555125 low density lipoprotein receptor-related protein 3
[Homo sapiens]
(770 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|167555125 low density lipoprotein receptor-related protein 3 ... 1638 0.0
gi|7305525 low density lipoprotein-related protein 12 isoform a ... 606 e-173
gi|208973262 low density lipoprotein-related protein 12 isoform ... 605 e-173
gi|32490559 low density lipoprotein receptor-related protein 10 ... 439 e-123
gi|126012562 low density lipoprotein-related protein 1 [Homo sap... 133 7e-31
gi|126012573 low density lipoprotein-related protein 2 [Homo sap... 127 4e-29
gi|13899255 membrane frizzled-related protein [Homo sapiens] 125 2e-28
gi|93102379 low density lipoprotein-related protein 1B precursor... 122 1e-27
gi|4507157 sortilin-related receptor containing LDLR class A rep... 121 2e-27
gi|134031945 SCO-spondin [Homo sapiens] 117 5e-26
gi|157384998 low density lipoprotein receptor-related protein 4 ... 103 6e-22
gi|11415040 matriptase [Homo sapiens] 99 1e-20
gi|4504975 low density lipoprotein receptor precursor [Homo sapi... 95 3e-19
gi|65301164 very low density lipoprotein receptor isoform b [Hom... 93 1e-18
gi|65301167 very low density lipoprotein receptor isoform a [Hom... 93 1e-18
gi|28557796 low density lipoprotein receptor class A domain cont... 91 4e-18
gi|61744471 low density lipoprotein receptor-related protein 8 i... 91 5e-18
gi|65301119 low density lipoprotein receptor-related protein 8 i... 91 5e-18
gi|29244926 corin [Homo sapiens] 90 9e-18
gi|119709832 low density lipoprotein receptor-related protein 5 ... 88 3e-17
gi|148727288 low density lipoprotein receptor-related protein 6 ... 87 8e-17
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 86 2e-16
gi|126091152 cubilin [Homo sapiens] 85 2e-16
gi|61744467 low density lipoprotein receptor-related protein 8 i... 84 4e-16
gi|66082554 low density lipoprotein receptor-related protein 8 i... 79 2e-14
gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa... 78 3e-14
gi|6912724 tolloid-like 2 [Homo sapiens] 74 7e-13
gi|222831592 transmembrane protease, serine 7 [Homo sapiens] 73 1e-12
gi|22547221 tolloid-like 1 [Homo sapiens] 72 1e-12
gi|23957702 transmembrane protease, serine 6 [Homo sapiens] 69 1e-11
>gi|167555125 low density lipoprotein receptor-related protein 3
[Homo sapiens]
Length = 770
Score = 1638 bits (4241), Expect = 0.0
Identities = 770/770 (100%), Positives = 770/770 (100%)
Query: 1 MEKRAAAGLEGAPGARAQLAVVCLVNIFLTGRLSSAVPALAACSGKLEQHTERRGVIYSP 60
MEKRAAAGLEGAPGARAQLAVVCLVNIFLTGRLSSAVPALAACSGKLEQHTERRGVIYSP
Sbjct: 1 MEKRAAAGLEGAPGARAQLAVVCLVNIFLTGRLSSAVPALAACSGKLEQHTERRGVIYSP 60
Query: 61 AWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSLDWLLLGPAAPPRQEAFRLC 120
AWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSLDWLLLGPAAPPRQEAFRLC
Sbjct: 61 AWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSLDWLLLGPAAPPRQEAFRLC 120
Query: 121 GSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYIRGKLGQASCQADEFRCDNGKCLP 180
GSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYIRGKLGQASCQADEFRCDNGKCLP
Sbjct: 121 GSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYIRGKLGQASCQADEFRCDNGKCLP 180
Query: 181 GPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARSTRCLPVERRCDGLQDC 240
GPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARSTRCLPVERRCDGLQDC
Sbjct: 181 GPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARSTRCLPVERRCDGLQDC 240
Query: 241 GDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARGPSDLHCTWLVDTQDSRRVLLQLEL 300
GDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARGPSDLHCTWLVDTQDSRRVLLQLEL
Sbjct: 241 GDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARGPSDLHCTWLVDTQDSRRVLLQLEL 300
Query: 301 RLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQGRLTVAYHARARSAGHGFNA 360
RLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQGRLTVAYHARARSAGHGFNA
Sbjct: 301 RLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQGRLTVAYHARARSAGHGFNA 360
Query: 361 TYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQRCDGWWHCASGRDEQGCPACPPDQ 420
TYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQRCDGWWHCASGRDEQGCPACPPDQ
Sbjct: 361 TYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQRCDGWWHCASGRDEQGCPACPPDQ 420
Query: 421 YPCEGGSGLCYTPADRCNNQKSCPDGADEKNCFSCQPGTFHCGTNLCIFETWRCDGQEDC 480
YPCEGGSGLCYTPADRCNNQKSCPDGADEKNCFSCQPGTFHCGTNLCIFETWRCDGQEDC
Sbjct: 421 YPCEGGSGLCYTPADRCNNQKSCPDGADEKNCFSCQPGTFHCGTNLCIFETWRCDGQEDC 480
Query: 481 QDGSDEHGCLAAVPRKVITAALIGSLVCGLLLVIALGCAFKLYSLRTQEYRAFETQMTRL 540
QDGSDEHGCLAAVPRKVITAALIGSLVCGLLLVIALGCAFKLYSLRTQEYRAFETQMTRL
Sbjct: 481 QDGSDEHGCLAAVPRKVITAALIGSLVCGLLLVIALGCAFKLYSLRTQEYRAFETQMTRL 540
Query: 541 EAEFVRREAPPSYGQLIAQGLIPPVEDFPVYSASQASVLQNLRTAMRRQMRRHASRRGPS 600
EAEFVRREAPPSYGQLIAQGLIPPVEDFPVYSASQASVLQNLRTAMRRQMRRHASRRGPS
Sbjct: 541 EAEFVRREAPPSYGQLIAQGLIPPVEDFPVYSASQASVLQNLRTAMRRQMRRHASRRGPS 600
Query: 601 RRRLGRLWNRLFHRPRAPRGQIPLLTAARPSQTVLGDGFLQPAPGAAPDPPAPLMDTGST 660
RRRLGRLWNRLFHRPRAPRGQIPLLTAARPSQTVLGDGFLQPAPGAAPDPPAPLMDTGST
Sbjct: 601 RRRLGRLWNRLFHRPRAPRGQIPLLTAARPSQTVLGDGFLQPAPGAAPDPPAPLMDTGST 660
Query: 661 RAAGDRPPSAPGRAPEVGPSGPPLPSGLRDPECRPVDKDRKVCREPLVDGPAPADAPREP 720
RAAGDRPPSAPGRAPEVGPSGPPLPSGLRDPECRPVDKDRKVCREPLVDGPAPADAPREP
Sbjct: 661 RAAGDRPPSAPGRAPEVGPSGPPLPSGLRDPECRPVDKDRKVCREPLVDGPAPADAPREP 720
Query: 721 CSAQDPHPQVSTASSTLGPHSPEPLGVCRNPPPPCSPMLEASDDEALLVC 770
CSAQDPHPQVSTASSTLGPHSPEPLGVCRNPPPPCSPMLEASDDEALLVC
Sbjct: 721 CSAQDPHPQVSTASSTLGPHSPEPLGVCRNPPPPCSPMLEASDDEALLVC 770
>gi|7305525 low density lipoprotein-related protein 12 isoform a
precursor [Homo sapiens]
Length = 859
Score = 606 bits (1563), Expect = e-173
Identities = 308/636 (48%), Positives = 412/636 (64%), Gaps = 42/636 (6%)
Query: 12 APGARAQLAVVCLVNIFLTGRLSSAVPAL------AACSGKLEQHTERRGVIYSPAWPLN 65
+P R+ L ++ L ++ G L+ + AC EQ G+I SP WP
Sbjct: 10 SPRWRSALLLLFLAGVYGNGALAEHSENVHISGVSTACGETPEQIRAPSGIITSPGWPSE 69
Query: 66 YPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSLDWLLLGPAAPPRQEAFRLCGSAIP 125
YP NCSW+I+ + G++ITISF++FD++ S +C+LDWL + E++R CGS IP
Sbjct: 70 YPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTI--ETYKNIESYRACGSTIP 127
Query: 126 PAFISARDHVWIFFHSDASSSGQAQGFRLSYIRGKLGQASCQADEFRCDNGKCLPGPWQC 185
P +IS++DH+WI FHSD + S +GFRL+Y GK + +C D+FRC NGKC+P W+C
Sbjct: 128 PPYISSQDHIWIRFHSDDNIS--RKGFRLAYFSGKSEEPNCACDQFRCGNGKCIPEAWKC 185
Query: 186 NTVDECGDGSDEGNCSAPASEPPGSL---CPGGTFPCSGARSTR---CLPVERRCDGLQD 239
N +DECGD SDE C+ A+ P + C F C +R T+ CLP +CDG D
Sbjct: 186 NNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCL-SRFTKVYTCLPESLKCDGNID 244
Query: 240 CGDGSDEAGCPDLACGRRLGSFYGSFASP---DLFGAARGPSDLHCTWLVDTQDSRRVLL 296
C D DE C CG+ L FYG+F SP D + P +CTWL+DT D R+V+L
Sbjct: 245 CLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFY-----PPGSNCTWLIDTGDHRKVIL 299
Query: 297 QL-ELRL---GYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQGRLTVAYHARAR 352
+ + +L GY DYV++Y+GL E +LL+ L+ +H P+++ ++ G++ V + A
Sbjct: 300 RFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKV 359
Query: 353 SAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQRCDGWWHCASGRDEQG 412
+A GFNATYQV G+CLPWE PCG G+ GC++E QRCDG+WHC +GRDE
Sbjct: 360 NAARGFNATYQVDGFCLPWEIPCG----------GNWGCYTEQQRCDGYWHCPNGRDETN 409
Query: 413 CPACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCFSCQPGTFHCGTNLCIFETW 472
C C +++PC +G+CY +DRCN Q CP+G+DEKNCF CQPG FHC N C+FE+W
Sbjct: 410 CTMCQKEEFPCSR-NGVCYPRSDRCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESW 468
Query: 473 RCDGQEDCQDGSDEHGCLAAVPRKVITAALIGSLVCGLLLVIALGCAFKLYSLRTQEYRA 532
CD Q+DC DGSDE C VP +VITAA+IGSL+CGLLLVIALGC KLYSLR E R+
Sbjct: 469 VCDSQDDCGDGSDEENCPVIVPTRVITAAVIGSLICGLLLVIALGCTCKLYSLRMFERRS 528
Query: 533 FETQMTRLEAEFVRREAPPSYGQLIAQGLIPPVEDFPVYSASQASVLQNLRTAMRRQMRR 592
FETQ++R+EAE +RREAPPSYGQLIAQGLIPPVEDFPV S +QASVL+NLR A+R Q+
Sbjct: 529 FETQLSRVEAELLRREAPPSYGQLIAQGLIPPVEDFPVCSPNQASVLENLRLAVRSQL-G 587
Query: 593 HASRRGPSRRRLGRLWNRLFHRPRAPR-GQIPLLTA 627
S R P R +WNR+F+ R+ G + L++A
Sbjct: 588 FTSVRLPMAGRSSNIWNRIFNFARSRHSGSLALVSA 623
>gi|208973262 low density lipoprotein-related protein 12 isoform b
precursor [Homo sapiens]
Length = 840
Score = 605 bits (1559), Expect = e-173
Identities = 302/600 (50%), Positives = 398/600 (66%), Gaps = 36/600 (6%)
Query: 42 ACSGKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSL 101
AC EQ G+I SP WP YP NCSW+I+ + G++ITISF++FD++ S +C+L
Sbjct: 27 ACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNL 86
Query: 102 DWLLLGPAAPPRQEAFRLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYIRGKL 161
DWL + E++R CGS IPP +IS++DH+WI FHSD + S +GFRL+Y GK
Sbjct: 87 DWLTI--ETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNIS--RKGFRLAYFSGKS 142
Query: 162 GQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSL---CPGGTFP 218
+ +C D+FRC NGKC+P W+CN +DECGD SDE C+ A+ P + C F
Sbjct: 143 EEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQ 202
Query: 219 CSGARSTR---CLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASP---DLFG 272
C +R T+ CLP +CDG DC D DE C CG+ L FYG+F SP D +
Sbjct: 203 CL-SRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFY- 260
Query: 273 AARGPSDLHCTWLVDTQDSRRVLLQL-ELRL---GYDDYVQVYEGLGERGDRLLQTLSYR 328
P +CTWL+DT D R+V+L+ + +L GY DYV++Y+GL E +LL+ L+
Sbjct: 261 ----PPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAF 316
Query: 329 SNHRPVSLEAAQGRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGD 388
+H P+++ ++ G++ V + A +A GFNATYQV G+CLPWE PCG G+
Sbjct: 317 DSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCG----------GN 366
Query: 389 QGCFSEPQRCDGWWHCASGRDEQGCPACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGAD 448
GC++E QRCDG+WHC +GRDE C C +++PC +G+CY +DRCN Q CP+G+D
Sbjct: 367 WGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPCSR-NGVCYPRSDRCNYQNHCPNGSD 425
Query: 449 EKNCFSCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCLAAVPRKVITAALIGSLVC 508
EKNCF CQPG FHC N C+FE+W CD Q+DC DGSDE C VP +VITAA+IGSL+C
Sbjct: 426 EKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVIVPTRVITAAVIGSLIC 485
Query: 509 GLLLVIALGCAFKLYSLRTQEYRAFETQMTRLEAEFVRREAPPSYGQLIAQGLIPPVEDF 568
GLLLVIALGC KLYSLR E R+FETQ++R+EAE +RREAPPSYGQLIAQGLIPPVEDF
Sbjct: 486 GLLLVIALGCTCKLYSLRMFERRSFETQLSRVEAELLRREAPPSYGQLIAQGLIPPVEDF 545
Query: 569 PVYSASQASVLQNLRTAMRRQMRRHASRRGPSRRRLGRLWNRLFHRPRAPR-GQIPLLTA 627
PV S +QASVL+NLR A+R Q+ S R P R +WNR+F+ R+ G + L++A
Sbjct: 546 PVCSPNQASVLENLRLAVRSQL-GFTSVRLPMAGRSSNIWNRIFNFARSRHSGSLALVSA 604
>gi|32490559 low density lipoprotein receptor-related protein 10
precursor [Homo sapiens]
Length = 713
Score = 439 bits (1130), Expect = e-123
Identities = 284/754 (37%), Positives = 365/754 (48%), Gaps = 113/754 (14%)
Query: 42 ACSGKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSL 101
AC E +G + P + NC+W I G + +TI F+ + C
Sbjct: 27 ACEDPPAVLLEVQGTLQRPLVRDSRTSPANCTWLILGSKEQTVTIRFQKLHLA----CGS 82
Query: 102 DWLLLGPAAPPRQEAFRLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYIRGKL 161
+ L L P Q LC + P + +V I + + + QGF LSY + L
Sbjct: 83 ERLTL---RSPLQPLISLCEAPPSPLQLPG-GNVTITYSYAGARAPMGQGFLLSYSQDWL 138
Query: 162 GQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSG 221
C +EF+C N
Sbjct: 139 ---MCLQEEFQCLNH--------------------------------------------- 150
Query: 222 ARSTRCLPVERRCDGLQDCGDGSDEAGC-------------PDLACGRRLGSFYGSFASP 268
RC+ +RCDG+ CGDGSDEAGC P L C L FYG F+SP
Sbjct: 151 ----RCVSAVQRCDGVDACGDGSDEAGCSSDPFPGLTPRPVPSLPCNVTLEDFYGVFSSP 206
Query: 269 DLFGAARGPSDLHCTWLVDTQDSRRVLLQLE-LRLGYDDYVQVYEGLGE-RGDRLLQTLS 326
A C WL+D D RR+ ++ L LG+ D V VY+G G RLL++L+
Sbjct: 207 GYTHLASVSHPQSCHWLLDPHDGRRLAVRFTALDLGFGDAVHVYDGPGPPESSRLLRSLT 266
Query: 327 YRSNHRPVSLEAAQGRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSL 386
+ SN + V++E G+ V+YH A S G GFNATY V+GYCLPW++PCG S G
Sbjct: 267 HFSNGKAVTVETLSGQAVVSYHTVAWSNGRGFNATYHVRGYCLPWDRPCGLGSGLGAGEG 326
Query: 387 GDQGCFSEPQRCDGWWHCASGRDEQGCPACPPDQYPC----EGGSGLCYTPADRCNNQKS 442
+ C+SE QRCDG W CA G DE+ CP CPP +PC G+ CY PADRCN Q
Sbjct: 327 LGERCYSEAQRCDGSWDCADGTDEEDCPGCPPGHFPCGAAGTSGATACYLPADRCNYQTF 386
Query: 443 CPDGADEKNCFSCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCLAAVPRKVITAAL 502
C DGADE+ C CQPG F C C++ETW CDGQ DC DGSDE C +PRKVITAA+
Sbjct: 387 CADGADERRCRHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCSYVLPRKVITAAV 446
Query: 503 IGSLVCGLLLVIALGCAFKLYSLRTQEYRAFETQMTRLEAEFVRREAPPSYGQLIAQGLI 562
IGSLVCGLLLVIALGC KLY++RTQEY F ++R+EAE V+++APPSYGQLIAQG I
Sbjct: 447 IGSLVCGLLLVIALGCTCKLYAIRTQEYSIF-APLSRMEAEIVQQQAPPSYGQLIAQGAI 505
Query: 563 PPVEDFPVYSASQASVLQNLRTAMR--RQMRRHASRRGPSRRRLGRLWNRLFHRPR---- 616
PPVEDFP + + SVL NLR+ ++ RQ G RR+ GRL RL R R
Sbjct: 506 PPVEDFPTENPNDNSVLGNLRSLLQILRQDMTPGGGPGARRRQRGRLMRRLVRRLRRWGL 565
Query: 617 APRGQIPLLTAARPSQTVLGDGFLQPAPGAAPDPPAPLMDTGSTRAA-GDRPPSAPGRAP 675
PR P + SQ L+ G P + G+ G++ P P +AP
Sbjct: 566 LPRTNTPARASEARSQVTPSAAPLEALDGGT----GPAREGGAVGGQDGEQAPPLPIKAP 621
Query: 676 EVGPSGPPLPSGLRDPECRPVDKDRKVCREPLVDGPAPADAPREPCSAQDPHPQVSTASS 735
S P P+ + P GP P+ P EP V
Sbjct: 622 LPSASTSPAPTTV-----------------PEAPGPLPS-LPLEPSLLSG---VVQALRG 660
Query: 736 TLGPHSPEPLGVCRNPPPPCSPMLEASDDEALLV 769
L P S P G R+PP P + +L D++ +L+
Sbjct: 661 RLLP-SLGPPGPTRSPPGPHTAVLALEDEDDVLL 693
Score = 50.8 bits (120), Expect = 5e-06
Identities = 62/237 (26%), Positives = 94/237 (39%), Gaps = 51/237 (21%)
Query: 37 VPALAACSGKLEQHTERRGVIYSPAWP----LNYPPGTNCSWYIQGDRGDMITISFRNFD 92
VP+L C+ LE GV SP + +++P +C W + G + + F D
Sbjct: 187 VPSLP-CNVTLEDFY---GVFSSPGYTHLASVSHPQ--SCHWLLDPHDGRRLAVRFTALD 240
Query: 93 VEESHQCSLDWLLLGPAAPPRQEAFRLC-----GSAIPPAFISARDHVWIFFHSDASSSG 147
+ + GP P R G A+ +S + + +H+ A S+G
Sbjct: 241 LGFGDAVHV---YDGPGPPESSRLLRSLTHFSNGKAVTVETLSGQ--AVVSYHTVAWSNG 295
Query: 148 QAQGFRLSY-IRGKLGQASCQADEFRCDNG-----------KCLPGPWQCNTVDECGDGS 195
+ GF +Y +RG C + C G +C +C+ +C DG+
Sbjct: 296 R--GFNATYHVRGY-----CLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGT 348
Query: 196 DEGNCSAPASEPPGSLCPGGTFPCSGA---RSTRCLPVERRCDGLQDCGDGSDEAGC 249
DE +C PG CP G FPC A +T C RC+ C DG+DE C
Sbjct: 349 DEEDC-------PG--CPPGHFPCGAAGTSGATACYLPADRCNYQTFCADGADERRC 396
>gi|126012562 low density lipoprotein-related protein 1 [Homo sapiens]
Length = 4544
Score = 133 bits (334), Expect = 7e-31
Identities = 101/382 (26%), Positives = 149/382 (39%), Gaps = 75/382 (19%)
Query: 159 GKLGQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEG-------------NCSAPAS 205
G+ ++C A +F C N KC+P W+C+T D+CGD SDE CS
Sbjct: 3327 GRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGIC 3386
Query: 206 EPPGSLCPGGT--------------------FPCSGARSTRCLPVERRCDGLQDCGDGSD 245
P +C G F C+ + RC+P RC+G +CGDG D
Sbjct: 3387 TNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTN--TNRCIPGIFRCNGQDNCGDGED 3444
Query: 246 EAGCPDLACGRRLGSFYGSFASPDLFGAARGPSDLHCTWLVDTQD-----SRRVLLQLEL 300
E CP++ C +P+ F + + W+ D + S ++
Sbjct: 3445 ERDCPEVTC------------APNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQM 3492
Query: 301 RLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQGRLTVAYHARARSAGHGFNA 360
G D++ G + E R Y R ++ N
Sbjct: 3493 TCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKN-----NR 3547
Query: 361 TYQVKGYCLPWEQPCGSSSDSDGG----------SLGDQGCFSEPQRCDGWWHCASGRDE 410
+ C ++ CG +SD + S + C + +CDG CA G DE
Sbjct: 3548 CVPGRWQC-DYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDE 3606
Query: 411 QGC-PACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCFS----CQPGTFHCGTN 465
+ C P C DQ+ C+ SG C RC+ C DG+DE+ C + C F C
Sbjct: 3607 KDCTPRCDMDQFQCK--SGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNT 3664
Query: 466 LCIFETWRCDGQEDCQDGSDEH 487
LC W+CDG++DC D SDE+
Sbjct: 3665 LCKPLAWKCDGEDDCGDNSDEN 3686
Score = 107 bits (266), Expect = 5e-23
Identities = 95/338 (28%), Positives = 130/338 (38%), Gaps = 63/338 (18%)
Query: 163 QASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTF--PCS 220
+ +C EFRC +G C+ +CN +C D SDE NCSA L G PC
Sbjct: 2602 KTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCE 2661
Query: 221 GARSTRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARGPSDL 280
R++ C CDG DCGD SDE CP + R P + A +
Sbjct: 2662 --RTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPR----------CPLNYFACPSGRCI 2709
Query: 281 HCTWLVDTQDSRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYR-SNHRPVSLE-A 338
+W D +D + G D+ ++ + NHR +S +
Sbjct: 2710 PMSWTCDKED--------DCEHGEDE---------THCNKFCSEAQFECQNHRCISKQWL 2752
Query: 339 AQGRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQRC 398
G + G G + +G + CG SS S G+ C E C
Sbjct: 2753 CDG---------SDDCGDGSDEAAHCEG------KTCGPSSFSCPGT---HVCVPERWLC 2794
Query: 399 DGWWHCASGRDEQ---GC---PACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEK-N 451
DG CA G DE GC C ++ C+ C C++ + C DG+DE
Sbjct: 2795 DGDKDCADGADESIAAGCLYNSTCDDREFMCQNRQ--CIPKHFVCDHDRDCADGSDESPE 2852
Query: 452 CF--SCQPGTFHCGTNLCI-FETWRCDGQEDCQDGSDE 486
C +C P F C C+ W CDG+ DC D SDE
Sbjct: 2853 CEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDE 2890
Score = 104 bits (260), Expect = 3e-22
Identities = 99/338 (29%), Positives = 136/338 (40%), Gaps = 57/338 (16%)
Query: 164 ASCQA-DEFRCDNGKCLPGPWQCNTVDECGDGSDE--GNCSAPASEPPGSLCPGGTFPCS 220
+SC+A DEF C NG+C+ C+ V C D SDE C++ + C G
Sbjct: 2522 SSCRAQDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNG----- 2576
Query: 221 GARSTRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARGPSDL 280
RC+ C+G DCGDGSDE C ACG G F D G G S
Sbjct: 2577 -----RCVSNMLWCNGADDCGDGSDEIPCNKTACG------VGEFRCRD--GTCIGNSS- 2622
Query: 281 HCTWLVDTQDSRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQ 340
C VD +D+ E+ D Y LG +G V + +
Sbjct: 2623 RCNQFVDCEDASD-----EMNCSATD-CSSYFRLGVKG---------------VLFQPCE 2661
Query: 341 GRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQRCDG 400
R ++ Y G Y + C ++P + + C CD
Sbjct: 2662 -RTSLCYAPSWVCDGANDCGDYSDERDCPGVKRP---RCPLNYFACPSGRCIPMSWTCDK 2717
Query: 401 WWHCASGRDEQGC-PACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADE-KNC--FSCQ 456
C G DE C C Q+ C+ + C + C+ C DG+DE +C +C
Sbjct: 2718 EDDCEHGEDETHCNKFCSEAQFECQ--NHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCG 2775
Query: 457 PGTFHC-GTNLCIFETWRCDGQEDCQDGSDEH---GCL 490
P +F C GT++C+ E W CDG +DC DG+DE GCL
Sbjct: 2776 PSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCL 2813
Score = 103 bits (257), Expect = 6e-22
Identities = 95/358 (26%), Positives = 142/358 (39%), Gaps = 70/358 (19%)
Query: 166 CQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARST 225
CQ EF C N +C+ W+C+ ++C D SDE APA + CP F C +
Sbjct: 854 CQPGEFACANSRCIQERWKCDGDNDCLDNSDE----APALCHQHT-CPSDRFKCE---NN 905
Query: 226 RCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARGPSDLHCTWL 285
RC+P CDG DCG+ DE+ C R P+ F A G + +W
Sbjct: 906 RCIPNRWLCDGDNDCGNSEDESNA---TCSART-------CPPNQFSCASGRC-IPISWT 954
Query: 286 VDTQDSRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQGRLTV 345
D D Y + + G + +++R ++
Sbjct: 955 CDLDDDCGDRSDESASCAYPTCFPLTQFTCNNGRCI--NINWRCDNDN----------DC 1002
Query: 346 AYHARARSAGHGFNATYQVK---GYCLP--W----EQPCGSSSDSDGGSLGDQ------G 390
++ H ++T Q K G C+P W + CG SD + +Q G
Sbjct: 1003 GDNSDEAGCSHSCSST-QFKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGG 1061
Query: 391 CFSEP-------------QRCDGWWHCASGRDEQGCPA----CPPD-QYPCEGGSGLCYT 432
C ++ RCDG C DE+ C C P ++ C+ S C +
Sbjct: 1062 CHTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKD-SARCIS 1120
Query: 433 PADRCNNQKSCPDGADEKNC--FSCQPGTFHC--GTNLCIFETWRCDGQEDCQDGSDE 486
A C+ C D +DE+NC +C+P + C T++C+ CDG +DC DGSDE
Sbjct: 1121 KAWVCDGDNDCEDNSDEENCESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDE 1178
Score = 79.7 bits (195), Expect = 9e-15
Identities = 37/87 (42%), Positives = 51/87 (58%), Gaps = 5/87 (5%)
Query: 165 SCQADEFRCDNGKCLPGPWQCNTVDECGDGSDE--GNCSAPASEPPGSLCPGGTFPCSGA 222
SC + +F+C++G+C+P W C+ ++CGD SDE NC+ A+ PPG C F C
Sbjct: 1014 SCSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGG-CHTDEFQC--R 1070
Query: 223 RSTRCLPVERRCDGLQDCGDGSDEAGC 249
C+P+ RCDG DC D SDE C
Sbjct: 1071 LDGLCIPLRWRCDGDTDCMDSSDEKSC 1097
Score = 79.3 bits (194), Expect = 1e-14
Identities = 46/143 (32%), Positives = 57/143 (39%), Gaps = 19/143 (13%)
Query: 366 GYCLP--W----EQPCGSSSDSDGGSLGDQGCFSEPQRCD------GWWHC------ASG 407
G C+P W E CG SD ++ C RC G W C
Sbjct: 3505 GRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDN 3564
Query: 408 RDEQGCPACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCFS-CQPGTFHCGTNL 466
DE+ C P + +G C +C+ C DG+DEK+C C F C +
Sbjct: 3565 SDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCTPRCDMDQFQCKSGH 3624
Query: 467 CIFETWRCDGQEDCQDGSDEHGC 489
CI WRCD DC DGSDE C
Sbjct: 3625 CIPLRWRCDADADCMDGSDEEAC 3647
Score = 76.3 bits (186), Expect = 1e-13
Identities = 36/93 (38%), Positives = 50/93 (53%), Gaps = 9/93 (9%)
Query: 163 QASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGA 222
Q +C +D F+C+N +C+P W C+ ++CG+ DE N + A CP F C+
Sbjct: 892 QHTCPSDRFKCENNRCIPNRWLCDGDNDCGNSEDESNATCSA-----RTCPPNQFSCA-- 944
Query: 223 RSTRCLPVERRCDGLQDCGDGSDE-AGCPDLAC 254
S RC+P+ CD DCGD SDE A C C
Sbjct: 945 -SGRCIPISWTCDLDDDCGDRSDESASCAYPTC 976
Score = 74.3 bits (181), Expect = 4e-13
Identities = 39/101 (38%), Positives = 49/101 (48%), Gaps = 14/101 (13%)
Query: 401 WWHCASGRD-------EQGCPA--CPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKN 451
WW C + D CP C P Q+ C +G+C PA C+ C D +DE N
Sbjct: 3350 WWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCS--TGICTNPAFICDGDNDCQDNSDEAN 3407
Query: 452 C--FSCQPGTFHC-GTNLCIFETWRCDGQEDCQDGSDEHGC 489
C C P F C TN CI +RC+GQ++C DG DE C
Sbjct: 3408 CDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDC 3448
Score = 73.2 bits (178), Expect = 9e-13
Identities = 87/362 (24%), Positives = 122/362 (33%), Gaps = 70/362 (19%)
Query: 166 CQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARST 225
C + F C +G+C+P W C+ D+C G DE +C+ C F C ++
Sbjct: 2696 CPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHCN--------KFCSEAQFEC---QNH 2744
Query: 226 RCLPVERRCDGLQDCGDGSDEAG-CPDLACGRRLGSFYGSFASPDLFGAARGPSDLHCTW 284
RC+ + CDG DCGDGSDEA C CG S G+ G D C
Sbjct: 2745 RCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKD--CAD 2802
Query: 285 LVD-----------TQDSRRVLLQ----LELRLGYDDYVQVYEGLGERGDRLLQTLSYRS 329
D T D R + Q + D +G E + T
Sbjct: 2803 GADESIAAGCLYNSTCDDREFMCQNRQCIPKHFVCDHDRDCADGSDESPECEYPTCG--- 2859
Query: 330 NHRPVSLEAAQGRLTVA--YHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLG 387
P A GR + + + H + +C E C +SS L
Sbjct: 2860 ---PSEFRCANGRCLSSRQWECDGENDCHDQSDEAPKNPHCTSQEHKCNASSQ----FLC 2912
Query: 388 DQG-CFSEPQRCDGWWHCASGRDEQGC----------PACPPDQYPCEGGSGLCYTPADR 436
G C +E C+G C DE+GC C D + G P R
Sbjct: 2913 SSGRCVAEALLCNGQDDCGDSSDERGCHINECLSRKLSGCSQDCEDLKIGFKCRCRPGFR 2972
Query: 437 CNNQ-KSCPDGADEKNCFSCQP------GTFHCGTNLCIFETWRCDGQEDCQDGSDEHGC 489
+ ++C D + F C G++ C LC+ + G D H C
Sbjct: 2973 LKDDGRTCADVDECSTTFPCSQRCINTHGSYKC---LCV--------EGYAPRGGDPHSC 3021
Query: 490 LA 491
A
Sbjct: 3022 KA 3023
Score = 73.2 bits (178), Expect = 9e-13
Identities = 37/89 (41%), Positives = 48/89 (53%), Gaps = 8/89 (8%)
Query: 162 GQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLC-PGGTFPCS 220
G +C DEF+C+N C P W+C+ D+CGD SDE E +C P F C
Sbjct: 3650 GVRTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDEN-----PEECARFVCPPNRPFRCK 3704
Query: 221 GARSTRCLPVERRCDGLQDCGDGSDEAGC 249
R CL + R+CDG +CGDG+DE C
Sbjct: 3705 NDRV--CLWIGRQCDGTDNCGDGTDEEDC 3731
Score = 69.3 bits (168), Expect = 1e-11
Identities = 44/117 (37%), Positives = 53/117 (45%), Gaps = 10/117 (8%)
Query: 381 SDGGSLGDQGCFSEPQRCDGWWHCASGRDEQG--CPA--CPPDQYPCEGGSGLCYTPADR 436
SD + C CDG C + DE C A CPP+Q+ C SG C +
Sbjct: 897 SDRFKCENNRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSC--ASGRCIPISWT 954
Query: 437 CNNQKSCPDGADEK-NCF--SCQPGT-FHCGTNLCIFETWRCDGQEDCQDGSDEHGC 489
C+ C D +DE +C +C P T F C CI WRCD DC D SDE GC
Sbjct: 955 CDLDDDCGDRSDESASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGC 1011
Score = 68.2 bits (165), Expect = 3e-11
Identities = 51/155 (32%), Positives = 60/155 (38%), Gaps = 34/155 (21%)
Query: 366 GYCLP--W----EQPCGSSSDSDGGSLGDQGCFSEPQ-------------RCDGWWHCAS 406
G C+P W + CG SD + S CF Q RCD C
Sbjct: 946 GRCIPISWTCDLDDDCGDRSD-ESASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGD 1004
Query: 407 GRDEQGCP-ACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEK--NCFS--------C 455
DE GC +C Q+ C SG C C+ C D +DE NC + C
Sbjct: 1005 NSDEAGCSHSCSSTQFKCN--SGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGC 1062
Query: 456 QPGTFHCGTN-LCIFETWRCDGQEDCQDGSDEHGC 489
F C + LCI WRCDG DC D SDE C
Sbjct: 1063 HTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKSC 1097
Score = 67.0 bits (162), Expect = 6e-11
Identities = 44/143 (30%), Positives = 55/143 (38%), Gaps = 25/143 (17%)
Query: 359 NATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQRCDGWWHCASGRDEQGCPA--- 415
N +Y C P E C +S C E +CDG C DE PA
Sbjct: 845 NPSYVPPPQCQPGEFACANSR-----------CIQERWKCDGDNDCLDNSDE--APALCH 891
Query: 416 ---CPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCF----SCQPGTFHCGTNLCI 468
CP D++ CE C C+ C + DE N +C P F C + CI
Sbjct: 892 QHTCPSDRFKCENNR--CIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCI 949
Query: 469 FETWRCDGQEDCQDGSDEHGCLA 491
+W CD +DC D SDE A
Sbjct: 950 PISWTCDLDDDCGDRSDESASCA 972
Score = 62.4 bits (150), Expect = 2e-09
Identities = 32/87 (36%), Positives = 44/87 (50%), Gaps = 6/87 (6%)
Query: 407 GRDEQGCPA-CPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEK-NC--FSCQPGTFHC 462
G D + C + C Q+ C+ C +C+ + C D +DE +C F C+PG F C
Sbjct: 3324 GSDGRTCVSNCTASQFVCKNDK--CIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQC 3381
Query: 463 GTNLCIFETWRCDGQEDCQDGSDEHGC 489
T +C + CDG DCQD SDE C
Sbjct: 3382 STGICTNPAFICDGDNDCQDNSDEANC 3408
Score = 60.8 bits (146), Expect = 4e-09
Identities = 35/81 (43%), Positives = 43/81 (53%), Gaps = 7/81 (8%)
Query: 171 FRCDNGK-CLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPG-GTFPCSGARSTRCL 228
FRC N + CL QC+ D CGDG+DE +C P + + C F C R+ RCL
Sbjct: 3701 FRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTAHT--THCKDKKEFLC---RNQRCL 3755
Query: 229 PVERRCDGLQDCGDGSDEAGC 249
RC+ DCGDGSDE C
Sbjct: 3756 SSSLRCNMFDDCGDGSDEEDC 3776
Score = 60.5 bits (145), Expect = 6e-09
Identities = 30/79 (37%), Positives = 41/79 (51%), Gaps = 9/79 (11%)
Query: 416 CPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADE-------KNCFSCQPGTFHC-GTNLC 467
C P Q+ C C + RC+ ++ CPDG+DE CQP +C GT LC
Sbjct: 27 CSPKQFACRDQI-TCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELC 85
Query: 468 IFETWRCDGQEDCQDGSDE 486
+ + C+G +DC DGSDE
Sbjct: 86 VPMSRLCNGVQDCMDGSDE 104
Score = 59.7 bits (143), Expect = 1e-08
Identities = 37/101 (36%), Positives = 45/101 (44%), Gaps = 12/101 (11%)
Query: 149 AQGFRLSYIRGKLGQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEG-NCSAPASEP 207
A G S G L ++C EF C N +C+P + C+ +C DGSDE C P P
Sbjct: 2801 ADGADESIAAGCLYNSTCDDREFMCQNRQCIPKHFVCDHDRDCADGSDESPECEYPTCGP 2860
Query: 208 PGSLCPGGTFPCSGARSTRCLPVER-RCDGLQDCGDGSDEA 247
C G RCL + CDG DC D SDEA
Sbjct: 2861 SEFRCANG----------RCLSSRQWECDGENDCHDQSDEA 2891
Score = 59.7 bits (143), Expect = 1e-08
Identities = 46/179 (25%), Positives = 77/179 (43%), Gaps = 43/179 (24%)
Query: 366 GYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQ-------------------RCDGWWHCAS 406
G+C+P C + +D GS ++ C + + +CDG C
Sbjct: 3623 GHCIPLRWRCDADADCMDGS-DEEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGEDDCGD 3681
Query: 407 GRDE--QGCP--ACPPDQ-YPCEGGSGLCYTPADRCNNQKSCPDGADEKNCFSCQPGTFH 461
DE + C CPP++ + C+ +C +C+ +C DG DE++C +P T H
Sbjct: 3682 NSDENPEECARFVCPPNRPFRCKNDR-VCLWIGRQCDGTDNCGDGTDEEDC---EPPTAH 3737
Query: 462 -----------CGTNLCIFETWRCDGQEDCQDGSDEHGCLAAVPRKVITAALIGSLVCG 509
C C+ + RC+ +DC DGSDE C + P+ +T+ + +CG
Sbjct: 3738 TTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDC-SIDPK--LTSCATNASICG 3793
Score = 58.9 bits (141), Expect = 2e-08
Identities = 31/83 (37%), Positives = 42/83 (50%), Gaps = 5/83 (6%)
Query: 165 SCQADEFRC-DNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGAR 223
+C +F C D C+ W+C+ +C DGSDE P S+ C C G
Sbjct: 26 TCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSK--AQRCQPNEHNCLGTE 83
Query: 224 STRCLPVERRCDGLQDCGDGSDE 246
C+P+ R C+G+QDC DGSDE
Sbjct: 84 L--CVPMSRLCNGVQDCMDGSDE 104
Score = 58.9 bits (141), Expect = 2e-08
Identities = 36/107 (33%), Positives = 44/107 (41%), Gaps = 8/107 (7%)
Query: 391 CFSEPQRCDGWWHCASGRDEQ----GCPACPPDQYPCEGGSGLCYTPADRCNNQKSCPDG 446
C + CDG HC DE+ C C G C + CN C DG
Sbjct: 2537 CINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGR--CVSNMLWCNGADDCGDG 2594
Query: 447 ADEKNC--FSCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCLA 491
+DE C +C G F C CI + RC+ DC+D SDE C A
Sbjct: 2595 SDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSA 2641
Score = 55.8 bits (133), Expect = 1e-07
Identities = 32/104 (30%), Positives = 42/104 (40%), Gaps = 5/104 (4%)
Query: 391 CFSEPQRCDGWWHCASGRDEQGCP--ACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGAD 448
C S+ CDG C DE+ C AC P +PC + +C P C+ C DG+D
Sbjct: 1118 CISKAWVCDGDNDCEDNSDEENCESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSD 1177
Query: 449 E-KNCFSCQPGTFHCGTNLCIF--ETWRCDGQEDCQDGSDEHGC 489
E + C C C N + E C + G D H C
Sbjct: 1178 EGELCDQCSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTC 1221
Score = 52.0 bits (123), Expect = 2e-06
Identities = 31/76 (40%), Positives = 36/76 (47%), Gaps = 17/76 (22%)
Query: 425 GGSGLCY-TPADRCNNQKSCPDG----ADEKNCFS---------CQPGTFHCGTNLCIFE 470
G S LC TP R Q +C + AD C + CQPG F C + CI E
Sbjct: 813 GCSSLCLATPGSR---QCACAEDQVLDADGVTCLANPSYVPPPQCQPGEFACANSRCIQE 869
Query: 471 TWRCDGQEDCQDGSDE 486
W+CDG DC D SDE
Sbjct: 870 RWKCDGDNDCLDNSDE 885
Score = 47.8 bits (112), Expect = 4e-05
Identities = 30/93 (32%), Positives = 41/93 (44%), Gaps = 7/93 (7%)
Query: 170 EFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARSTRCLP 229
EF C N +CL +CN D+CGDGSDE +CS +P + C C RC+
Sbjct: 3746 EFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSI---DPKLTSCATNASICGD--EARCVR 3800
Query: 230 VERR--CDGLQDCGDGSDEAGCPDLACGRRLGS 260
E+ C + GC D+ R G+
Sbjct: 3801 TEKAAYCACRSGFHTVPGQPGCQDINECLRFGT 3833
Score = 47.4 bits (111), Expect = 5e-05
Identities = 30/91 (32%), Positives = 41/91 (45%), Gaps = 9/91 (9%)
Query: 163 QASCQADEFRCDNGKC------LPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGT 216
Q ++ R +NG C PG QC ++ +D C A S P C G
Sbjct: 799 QQQVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYVPPPQCQPGE 858
Query: 217 FPCSGARSTRCLPVERRCDGLQDCGDGSDEA 247
F C+ ++RC+ +CDG DC D SDEA
Sbjct: 859 FACA---NSRCIQERWKCDGDNDCLDNSDEA 886
Score = 45.8 bits (107), Expect = 1e-04
Identities = 30/98 (30%), Positives = 40/98 (40%), Gaps = 14/98 (14%)
Query: 404 CASGR---DEQGCPAC-----PPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEK----N 451
C GR D+ C A D++ C G C + C+ C D +DEK N
Sbjct: 2505 CRGGRILQDDLTCRAVNSSCRAQDEFECANGE--CINFSLTCDGVPHCKDKSDEKPSYCN 2562
Query: 452 CFSCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGC 489
C+ C C+ C+G +DC DGSDE C
Sbjct: 2563 SRRCKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPC 2600
Score = 45.1 bits (105), Expect = 3e-04
Identities = 25/66 (37%), Positives = 34/66 (51%), Gaps = 8/66 (12%)
Query: 391 CFSEPQRCDGWWHCASGRDE--QGCP-----ACPPDQYPCEGGSGLCYTPADRCNNQKSC 443
C S+ RCDG C G DE + CP C P+++ C G+ LC + CN + C
Sbjct: 40 CISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCL-GTELCVPMSRLCNGVQDC 98
Query: 444 PDGADE 449
DG+DE
Sbjct: 99 MDGSDE 104
Score = 45.1 bits (105), Expect = 3e-04
Identities = 43/155 (27%), Positives = 66/155 (42%), Gaps = 13/155 (8%)
Query: 168 ADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGAR---S 224
+ +F C +G+C+ CN D+CGD SDE C +E G + C +
Sbjct: 2907 SSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCH--INECLSRKLSGCSQDCEDLKIGFK 2964
Query: 225 TRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFG-AARGPSDLHCT 283
RC P R D + C D DE C +R + +GS+ + G A RG C
Sbjct: 2965 CRCRPGFRLKDDGRTCAD-VDECS-TTFPCSQRCINTHGSYKCLCVEGYAPRGGDPHSCK 3022
Query: 284 WLVDTQD----SRRVLLQLELRLGYDDYVQVYEGL 314
+ D + + R L+ +L L +Y + +GL
Sbjct: 3023 AVTDEEPFLIFANRYYLR-KLNLDGSNYTLLKQGL 3056
Score = 44.7 bits (104), Expect = 3e-04
Identities = 18/34 (52%), Positives = 22/34 (64%), Gaps = 1/34 (2%)
Query: 454 SCQPGTFHCGTNL-CIFETWRCDGQEDCQDGSDE 486
+C P F C + CI + WRCDG+ DC DGSDE
Sbjct: 26 TCSPKQFACRDQITCISKGWRCDGERDCPDGSDE 59
Score = 37.0 bits (84), Expect = 0.069
Identities = 23/64 (35%), Positives = 28/64 (43%), Gaps = 8/64 (12%)
Query: 165 SCQADEFRCDNGK--CLPGPWQCNTVDECGDGSDEGNCSAPASEPPG------SLCPGGT 216
+C+ C N CLP C+ D+CGDGSDEG S G S+ PG
Sbjct: 1144 ACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQCSLNNGGCSHNCSVAPGEG 1203
Query: 217 FPCS 220
CS
Sbjct: 1204 IVCS 1207
Score = 33.9 bits (76), Expect = 0.59
Identities = 16/34 (47%), Positives = 20/34 (58%), Gaps = 1/34 (2%)
Query: 166 CQADEFRCDNGK-CLPGPWQCNTVDECGDGSDEG 198
CQ +E C + C+P CN V +C DGSDEG
Sbjct: 72 CQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDEG 105
Score = 32.3 bits (72), Expect = 1.7
Identities = 15/26 (57%), Positives = 17/26 (65%), Gaps = 2/26 (7%)
Query: 227 CLPVERRCDGLQDCGDGSDEAG--CP 250
C+ RCDG +DC DGSDEA CP
Sbjct: 40 CISKGWRCDGERDCPDGSDEAPEICP 65
>gi|126012573 low density lipoprotein-related protein 2 [Homo sapiens]
Length = 4655
Score = 127 bits (319), Expect = 4e-29
Identities = 110/386 (28%), Positives = 146/386 (37%), Gaps = 69/386 (17%)
Query: 166 CQADEFRCDNGKCLPGPWQCNTVDECGDGSD--EGNCSAPASEPPGSLCPGGTFPCSGAR 223
C A F C NG+C+ W+C+ ++CGDGSD E C+ P C G
Sbjct: 2700 CGASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANG-------- 2751
Query: 224 STRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARGPSDLHCT 283
RC+ RCD DCGDGSDEAGC C + G + H
Sbjct: 2752 --RCVQYSYRCDYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIPREFICNGVDNCHDN 2809
Query: 284 WLVDTQDSRRVLLQLELRLGYDDYV---QVY--EGLGERGDRLLQTLSYRSNHRPVSLE- 337
D ++ Q ++ + +VY +G + GD + +Y + H S E
Sbjct: 2810 NTSDEKNCPDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEF 2869
Query: 338 -AAQGRL----------TVAYHA--RARSAGHGFNATYQVK-----GYCLP--W----EQ 373
A GR T + A S GH + G C+P W +
Sbjct: 2870 QCASGRCIPQHWYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEWICDGDN 2929
Query: 374 PCGSSSDSD------------------GGSLGDQGCFSEPQRCDGWWHCASGRDE-QGCP 414
CG SD D D+ C + CDG C G DE Q C
Sbjct: 2930 DCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCT 2989
Query: 415 --ACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCF--SCQPGTFHCGTNLCIFE 470
C +++ C G GLC RC+ C D +DE+ C +CQ F C CI +
Sbjct: 2990 RRTCSENEFTC--GYGLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISK 3047
Query: 471 TWRCDGQEDCQDGSDE--HGCLAAVP 494
T+ CD DC DGSDE H C P
Sbjct: 3048 TFVCDEDNDCGDGSDELMHLCHTPEP 3073
Score = 105 bits (261), Expect = 2e-22
Identities = 94/357 (26%), Positives = 137/357 (38%), Gaps = 60/357 (16%)
Query: 165 SCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGS--LCPGGT-FPCSG 221
+C+ +FRC NG+C+P W+C+ ++CGD SDE P E S LC T F C
Sbjct: 3634 TCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDE-----PIEECMSSAHLCDNFTEFSCK- 3687
Query: 222 ARSTRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARGPSDLH 281
+ RC+P C+G+ DC D SDE GC + C +G F + +
Sbjct: 3688 -TNYRCIPKWAVCNGVDDCRDNSDEQGCEERTC-HPVGDF-----------RCKNHHCIP 3734
Query: 282 CTWLVDTQD-----------SRRVLLQLELRLGYDDYV------QVYEGLGERGDRLLQT 324
W D Q+ + R + E R + Y G+ D +
Sbjct: 3735 LRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDE--RD 3792
Query: 325 LSYRSNHRPVSLEAAQGRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGG 384
R+ H P + G H+ + G + C P P G+ +
Sbjct: 3793 CEMRTCH-PEYFQCTSGH---CVHSELKCDGSADCLDASDEADC-PTRFPDGAYCQATMF 3847
Query: 385 SLGDQGCFSEPQRCDGWWHCASGRDEQ-----GCPACPPDQYPCEGGSGLCYTPADRCNN 439
+ C +CDG C G DE+ P P+++ C+ + C + CN
Sbjct: 3848 ECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCD--NNRCIYSHEVCNG 3905
Query: 440 QKSCPDGAD--EKNCFS-----CQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGC 489
C DG D E++C C + CG CI CD +DC D SDE GC
Sbjct: 3906 VDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGC 3962
Score = 101 bits (252), Expect = 2e-21
Identities = 102/401 (25%), Positives = 149/401 (37%), Gaps = 109/401 (27%)
Query: 166 CQADEFRC-DNGKCLPGPWQCNTVDECGDGSDE------------------GNCSAPASE 206
C + +F C +N KC+P W+C+ +C DGSDE GNC++P +
Sbjct: 3512 CSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSDGNCTSPQTL 3571
Query: 207 -------PPGS----------LCPGGTFPCSGARSTRCLPVERRCDGLQDCGDGSDE--A 247
P GS C + C+ + RC+P +CD DC D SDE +
Sbjct: 3572 CNAHQNCPDGSDEDRLLCENHHCDSNEWQCA---NKRCIPESWQCDTFNDCEDNSDEDSS 3628
Query: 248 GCPDLACGRRLGSFYGSFASPDLFGAARG---PSDLHCTWLVDTQDSRRVLLQLELRLGY 304
C C P F A G P C D D
Sbjct: 3629 HCASRTC------------RPGQFRCANGRCIPQAWKCDVDNDCGDHS------------ 3664
Query: 305 DDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQGRLTVAYHARARSAGHGFN----- 359
D+ ++ D + S ++N+R + A + R S G
Sbjct: 3665 DEPIEECMSSAHLCDNFTE-FSCKTNYRCIPKWAVCNGVD---DCRDNSDEQGCEERTCH 3720
Query: 360 --ATYQVKGY-CLP--WE----QPCGSSSDSDGGSLGD----------QGCFSEPQRCDG 400
++ K + C+P W+ CG +SD + + + Q C CD
Sbjct: 3721 PVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDH 3780
Query: 401 WWHCASGRDEQGCP--ACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCFS---- 454
+ C DE+ C C P+ + C SG C +C+ C D +DE +C +
Sbjct: 3781 YNDCGDNSDERDCEMRTCHPEYFQCT--SGHCVHSELKCDGSADCLDASDEADCPTRFPD 3838
Query: 455 ---CQPGTFHCGTNLCIFETWRCDGQEDCQDGSDE--HGCL 490
CQ F C ++CI W+CDG +DC DGSDE H CL
Sbjct: 3839 GAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCL 3879
Score = 100 bits (249), Expect = 5e-21
Identities = 97/345 (28%), Positives = 131/345 (37%), Gaps = 75/345 (21%)
Query: 165 SCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGT-FPCSGAR 223
+C F C NG+C+ ++C+ ++CGDGSDE C C T F C+
Sbjct: 2740 TCSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGCLFRD-------CNATTEFMCN--- 2789
Query: 224 STRCLPVERRCDGLQDCGDG--SDEAGCPDLACGRRLGSFYGSFASPDLFGAARGPSDLH 281
+ RC+P E C+G+ +C D SDE CPD C G + H
Sbjct: 2790 NRRCIPREFICNGVDNCHDNNTSDEKNCPDRTC-------------------QSGYTKCH 2830
Query: 282 CTWLVDTQDSRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLE--AA 339
+ + + V + +G + GD + +Y + H S E A
Sbjct: 2831 NSNICIPR------------------VYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCA 2872
Query: 340 QGRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPC-GSSSDSDGGSLGDQGCFSEPQRC 398
GR + H F+A+ + C E+ C DGG C C
Sbjct: 2873 SGR-CIPQHWYCDQETDCFDASDE-PASCGHSERTCLADEFKCDGGR-----CIPSEWIC 2925
Query: 399 DGWWHCASGRDEQGCPACPPDQYPCEGGSGLCYT--PADR--------CNNQKSCPDGAD 448
DG C DE C C LC P DR C+ C DG D
Sbjct: 2926 DGDNDCGDMSDEDKRHQC--QNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYD 2983
Query: 449 E-KNCF--SCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCL 490
E +NC +C F CG LCI + +RCD DC D SDE GCL
Sbjct: 2984 ENQNCTRRTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGCL 3028
Score = 91.7 bits (226), Expect = 2e-18
Identities = 83/329 (25%), Positives = 119/329 (36%), Gaps = 57/329 (17%)
Query: 165 SCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNC--SAPASEPPGSLCPGGTFPCSGA 222
+C + F C +G+C+P W+C+ ++C DGSDE NC APAS C + C
Sbjct: 1066 TCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPAS------CLDTQYTCD-- 1117
Query: 223 RSTRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARGPSDLHC 282
+ +C+ CD DCGDGSDE C + + DL G D
Sbjct: 1118 -NHQCISKNWVCDTDNDCGDGSDEKNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKD--- 1173
Query: 283 TWLVDTQDSRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQGR 342
VD D +L + GD+ + +N + +
Sbjct: 1174 --CVDGSDEVGCVLN----------CTASQFKCASGDKCIGV----TNRCDGVFDCSDNS 1217
Query: 343 LTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQRCDGWW 402
R H Q G C+P C D GS C +
Sbjct: 1218 DEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPK-------- 1269
Query: 403 HCASGRDEQGCPACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNC----FSCQPG 458
CP + C+ G+ C A C+ C D +DEK+C F C
Sbjct: 1270 ------------TCPSSYFHCDNGN--CIHRAWLCDRDNDCGDMSDEKDCPTQPFRCPSW 1315
Query: 459 TFHC-GTNLCIFETWRCDGQEDCQDGSDE 486
+ C G N+C+ + CDG DC +G+DE
Sbjct: 1316 QWQCLGHNICVNLSVVCDGIFDCPNGTDE 1344
Score = 90.1 bits (222), Expect = 7e-18
Identities = 50/130 (38%), Positives = 65/130 (50%), Gaps = 13/130 (10%)
Query: 372 EQPCGSSSDSDGGSL---GDQGCFSEPQRCDGWWHCASGRDEQGCP-----ACPPDQYPC 423
EQ CG+ +++ S G C RCD C G DE CP +C QY C
Sbjct: 1057 EQLCGTLNNTCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTC 1116
Query: 424 EGGSGLCYTPADRCNNQKSCPDGADEKNCFS---CQPGTFHCGTNLCIFETWRCDGQEDC 480
+ C + C+ C DG+DEKNC S CQP F+C + CI ++ CDG +DC
Sbjct: 1117 DNHQ--CISKNWVCDTDNDCGDGSDEKNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDC 1174
Query: 481 QDGSDEHGCL 490
DGSDE GC+
Sbjct: 1175 VDGSDEVGCV 1184
Score = 89.0 bits (219), Expect = 2e-17
Identities = 88/340 (25%), Positives = 116/340 (34%), Gaps = 76/340 (22%)
Query: 166 CQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARST 225
C F C NG+C+P + C+ VD+C D SDE C + C F C
Sbjct: 1026 CGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGT-----LNNTCSSSAFTCGHG--- 1077
Query: 226 RCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARGPSDLHCTWL 285
C+P RCD DC DGSDE CP A L + Y + W+
Sbjct: 1078 ECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQY----------TCDNHQCISKNWV 1127
Query: 286 VDTQDSRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYRS----NHRPVSLE-AAQ 340
DT + +G E+ +T NHR + L
Sbjct: 1128 CDTDN------------------DCGDGSDEKNCNSTETCQPSQFNCPNHRCIDLSFVCD 1169
Query: 341 GRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDG-----GSLGDQGCFSEP 395
G + G N T + C ++ G ++ DG + + GC P
Sbjct: 1170 GDKDCV--DGSDEVGCVLNCTAS-QFKCASGDKCIGVTNRCDGVFDCSDNSDEAGC---P 1223
Query: 396 QRCDGWWHCASGRDEQGCP---ACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNC 452
R G H DE C C P+ + C+G C G+DE N
Sbjct: 1224 TRPPGMCH----SDEFQCQEDGICIPNFWECDG--------------HPDCLYGSDEHNA 1265
Query: 453 F---SCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGC 489
+C FHC CI W CD DC D SDE C
Sbjct: 1266 CVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDC 1305
Score = 88.6 bits (218), Expect = 2e-17
Identities = 83/337 (24%), Positives = 117/337 (34%), Gaps = 102/337 (30%)
Query: 165 SCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARS 224
+C + EF+C +G+C+P W C+ +C D SDE S SE C F C G
Sbjct: 2863 TCSSSEFQCASGRCIPQHWYCDQETDCFDASDE-PASCGHSE---RTCLADEFKCDGG-- 2916
Query: 225 TRCLPVERRCDGLQDCGDGSDE---AGCPDLACGRRLGSFYGSFASPDLFGAARGPSDLH 281
RC+P E CDG DCGD SDE C + C + + P D
Sbjct: 2917 -RCIPSEWICDGDNDCGDMSDEDKRHQCQNQNC-----------SDSEFLCVNDRPPDRR 2964
Query: 282 C---TWLVDTQDSRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEA 338
C +W+ D ++ GYD+ N
Sbjct: 2965 CIPQSWVCDG--------DVDCTDGYDE-----------------------NQNCTRRTC 2993
Query: 339 AQGRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQRC 398
++ T Y G C+P C +D G ++GC +
Sbjct: 2994 SENEFTCGY------------------GLCIPKIFRCDRHNDC-GDYSDERGCLYQ---- 3030
Query: 399 DGWWHCASGRDEQGCPACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADE--KNCFS-- 454
C +Q+ C+ +G C + C+ C DG+DE C +
Sbjct: 3031 ----------------TCQQNQFTCQ--NGRCISKTFVCDEDNDCGDGSDELMHLCHTPE 3072
Query: 455 --CQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGC 489
C P F C CI C+ +DC D SDE GC
Sbjct: 3073 PTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGC 3109
Score = 87.8 bits (216), Expect = 3e-17
Identities = 48/145 (33%), Positives = 60/145 (41%), Gaps = 20/145 (13%)
Query: 363 QVKGYCLPWEQPCGSSSDSDGGS-----------------LGDQGCFSEPQRCDGWWHCA 405
Q +G C+P C D D GS + C RCD C
Sbjct: 75 QSEGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCP 134
Query: 406 SGRDEQGCPACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCFS-CQPGTFHCGT 464
G DE C +Q C+ G+ CY + +C+ + C D +DE NC C F CG
Sbjct: 135 DGADENDCQYPTCEQLTCDNGA--CYNTSQKCDWKVDCRDSSDEINCTEICLHNEFSCGN 192
Query: 465 NLCIFETWRCDGQEDCQDGSDEHGC 489
CI + CD DCQDGSDEH C
Sbjct: 193 GECIPRAYVCDHDNDCQDGSDEHAC 217
Score = 87.0 bits (214), Expect = 6e-17
Identities = 89/372 (23%), Positives = 118/372 (31%), Gaps = 91/372 (24%)
Query: 166 CQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARST 225
C + FRC +G C+P W+C+ +C D +DE C+ C G F C
Sbjct: 28 CDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVT-------CQQGYFKCQS--EG 78
Query: 226 RCLPVERRCDGLQDCGDGSDE-AGCPDLACGRRLGSFYGSFASPDLFGAARG---PSDLH 281
+C+P CD QDC DGSDE C C S + G PS+
Sbjct: 79 QCIPNSWVCDQDQDCDDGSDERQDCSQSTC------------SSHQITCSNGQCIPSEYR 126
Query: 282 CTWLVDTQDSRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQG 341
C + D D + D T + +Q
Sbjct: 127 CDHVRDCPDG-----------------------ADENDCQYPTCEQLTCDNGACYNTSQ- 162
Query: 342 RLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQRCDGW 401
+ R + N T CL E CG+ C CD
Sbjct: 163 --KCDWKVDCRDSSDEINCT----EICLHNEFSCGNGE-----------CIPRAYVCDHD 205
Query: 402 WHCASGRDEQGC--PACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCFS----- 454
C G DE C P C Q+ C SG C C+ + C D DE C S
Sbjct: 206 NDCQDGSDEHACNYPTCGGYQFTCP--SGRCIYQNWVCDGEDDCKDNGDEDGCESGPHDV 263
Query: 455 --CQPGTFHC-GTNLCIFETWRCDGQEDCQDGSDEHGCLAAVPRKVITAALIGSLVCGLL 511
C P + C + CI CDG DC DE+ C +
Sbjct: 264 HKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTST-------------GKYCSMT 310
Query: 512 LVIALGCAFKLY 523
L AL C ++ +
Sbjct: 311 LCSALNCQYQCH 322
Score = 80.5 bits (197), Expect = 5e-15
Identities = 43/117 (36%), Positives = 55/117 (47%), Gaps = 30/117 (25%)
Query: 164 ASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNC-SAPASEPPGSLCPGG-----TF 217
ASC ++ CDN +C+ W C+T ++CGDGSDE NC S +P CP +F
Sbjct: 1107 ASCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNCNSTETCQPSQFNCPNHRCIDLSF 1166
Query: 218 PCSG------------------------ARSTRCLPVERRCDGLQDCGDGSDEAGCP 250
C G A +C+ V RCDG+ DC D SDEAGCP
Sbjct: 1167 VCDGDKDCVDGSDEVGCVLNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCP 1223
Score = 75.1 bits (183), Expect = 2e-13
Identities = 79/314 (25%), Positives = 113/314 (35%), Gaps = 78/314 (24%)
Query: 165 SCQADEFRCDN-GKCLPGPWQCNTVDECGDGSDEG-NCSAPASEPPGSLCPGGTFPCSGA 222
+CQ F+C + G+C+P W C+ +C DGSDE +CS S C CS
Sbjct: 66 TCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQ-------STCSSHQITCSNG 118
Query: 223 RSTRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRL---GSFYGSFASPDLFGAARGPSD 279
+ C+P E RCD ++DC DG+DE C C + G+ Y +
Sbjct: 119 Q---CIPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYN--------------TS 161
Query: 280 LHCTWLVDTQDSRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAA 339
C W VD +DS + E+ L + + G GE R +Y +H + +
Sbjct: 162 QKCDWKVDCRDSSDEINCTEICL----HNEFSCGNGECIPR-----AYVCDHDNDCQDGS 212
Query: 340 QGRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQRCD 399
HA G+ T G C+ C D
Sbjct: 213 D------EHACNYPTCGGYQFTCP-SGRCIYQNWVCDGEDD------------------- 246
Query: 400 GWWHCASGRDEQGCPACPPDQYPCE------GGSGLCYTPADRCNNQKSCPDGADEKNCF 453
C DE GC + P D + C SG C + C+ CP DE N
Sbjct: 247 ----CKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTS 302
Query: 454 SCQPGTFHCGTNLC 467
+ + +C LC
Sbjct: 303 TGK----YCSMTLC 312
Score = 71.6 bits (174), Expect = 3e-12
Identities = 48/153 (31%), Positives = 61/153 (39%), Gaps = 26/153 (16%)
Query: 366 GYCLPWEQPCGSSSDSDGGS-------------------LGDQGCFSEPQRCDGWWHCAS 406
G C+P C +D GS + C S+ CD C
Sbjct: 1077 GECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCGD 1136
Query: 407 GRDEQGCPA---CPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNC-FSCQPGTFHC 462
G DE+ C + C P Q+ C C + C+ K C DG+DE C +C F C
Sbjct: 1137 GSDEKNCNSTETCQPSQFNCPNHR--CIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKC 1194
Query: 463 GT-NLCIFETWRCDGQEDCQDGSDEHGCLAAVP 494
+ + CI T RCDG DC D SDE GC P
Sbjct: 1195 ASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPP 1227
Score = 70.5 bits (171), Expect = 6e-12
Identities = 39/119 (32%), Positives = 50/119 (42%), Gaps = 6/119 (5%)
Query: 376 GSSSDSDGGSLGDQGCFSEPQRCDGWWHCASGRDEQGCPA--CPPDQYPCEGGSGLCYTP 433
G DS G C RCDG C+ DE GC C + C+ G C
Sbjct: 25 GQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQS-EGQCIPN 83
Query: 434 ADRCNNQKSCPDGADEKNCFS---CQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGC 489
+ C+ + C DG+DE+ S C C CI +RCD DC DG+DE+ C
Sbjct: 84 SWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDC 142
Score = 70.1 bits (170), Expect = 7e-12
Identities = 37/92 (40%), Positives = 50/92 (54%), Gaps = 7/92 (7%)
Query: 158 RGKLGQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTF 217
RG L Q +CQ ++F C NG+C+ + C+ ++CGDGSDE EP CP F
Sbjct: 3025 RGCLYQ-TCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDELMHLCHTPEP---TCPPHEF 3080
Query: 218 PCSGARSTRCLPVERRCDGLQDCGDGSDEAGC 249
C RC+ + + C+ L DC D SDE GC
Sbjct: 3081 KCDNG---RCIEMMKLCNHLDDCLDNSDEKGC 3109
Score = 68.9 bits (167), Expect = 2e-11
Identities = 34/86 (39%), Positives = 44/86 (51%), Gaps = 6/86 (6%)
Query: 163 QASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGA 222
+ +C ADEF+CD G+C+P W C+ ++CGD SDE + C F C
Sbjct: 2903 ERTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDK----RHQCQNQNCSDSEFLCVND 2958
Query: 223 R--STRCLPVERRCDGLQDCGDGSDE 246
R RC+P CDG DC DG DE
Sbjct: 2959 RPPDRRCIPQSWVCDGDVDCTDGYDE 2984
Score = 66.6 bits (161), Expect = 8e-11
Identities = 30/95 (31%), Positives = 46/95 (48%), Gaps = 12/95 (12%)
Query: 158 RGKLGQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTF 217
R Q++C + + C NG+C+P ++C+ V +C DG+DE +C P E C G
Sbjct: 100 RQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCEQ--LTCDNGA- 156
Query: 218 PCSGARSTRCLPVERRCDGLQDCGDGSDEAGCPDL 252
C ++CD DC D SDE C ++
Sbjct: 157 ---------CYNTSQKCDWKVDCRDSSDEINCTEI 182
Score = 65.9 bits (159), Expect = 1e-10
Identities = 34/86 (39%), Positives = 44/86 (51%), Gaps = 13/86 (15%)
Query: 164 ASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEG---NCSAPASEPPGSLCPGGTFPCS 220
A CQA F C N C+P W+C+ D+CGDGSDE P + P F C
Sbjct: 3840 AYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSP-------NRFRCD 3892
Query: 221 GARSTRCLPVERRCDGLQDCGDGSDE 246
+ RC+ C+G+ DCGDG+DE
Sbjct: 3893 ---NNRCIYSHEVCNGVDDCGDGTDE 3915
Score = 65.5 bits (158), Expect = 2e-10
Identities = 33/99 (33%), Positives = 45/99 (45%), Gaps = 9/99 (9%)
Query: 399 DGWWHCASGRDE---QGCPACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCF-- 453
+G W+ A+ R C + C G C + +C+N C DG+DE
Sbjct: 2680 EGNWYLANNRKHCIVDNGERCGASSFTCSNGR--CISEEWKCDNDNDCGDGSDEMESVCA 2737
Query: 454 --SCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCL 490
+C P F C C+ ++RCD DC DGSDE GCL
Sbjct: 2738 LHTCSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGCL 2776
Score = 65.5 bits (158), Expect = 2e-10
Identities = 33/108 (30%), Positives = 46/108 (42%), Gaps = 6/108 (5%)
Query: 391 CFSEPQRCDGWWHCASGRDEQGCPA--CPPDQYPCEGGSGLCYTPADRCNNQKSCPDGAD 448
C +CDG C DE+ C C ++ C C C++ C D +D
Sbjct: 3732 CIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQ--CIPSRWICDHYNDCGDNSD 3789
Query: 449 EKNCF--SCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCLAAVP 494
E++C +C P F C + C+ +CDG DC D SDE C P
Sbjct: 3790 ERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADCPTRFP 3837
Score = 62.4 bits (150), Expect = 2e-09
Identities = 31/83 (37%), Positives = 38/83 (45%), Gaps = 6/83 (7%)
Query: 416 CPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCFS----CQPGTFHCGTNLCIFET 471
C +PC+ G C C+ C D +DE+ C + C F CG CI
Sbjct: 1026 CGLFSFPCKNGR--CVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECIPAH 1083
Query: 472 WRCDGQEDCQDGSDEHGCLAAVP 494
WRCD + DC DGSDEH C P
Sbjct: 1084 WRCDKRNDCVDGSDEHNCPTHAP 1106
Score = 62.4 bits (150), Expect = 2e-09
Identities = 29/83 (34%), Positives = 43/83 (51%), Gaps = 7/83 (8%)
Query: 165 SCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARS 224
+C + F CDNG C+ W C+ ++CGD SDE +C CP + C G
Sbjct: 1270 TCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCPTQPFR-----CPSWQWQCLG--H 1322
Query: 225 TRCLPVERRCDGLQDCGDGSDEA 247
C+ + CDG+ DC +G+DE+
Sbjct: 1323 NICVNLSVVCDGIFDCPNGTDES 1345
Score = 50.8 bits (120), Expect = 5e-06
Identities = 33/127 (25%), Positives = 52/127 (40%), Gaps = 14/127 (11%)
Query: 163 QASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSA-PASEPPGSLCPGG------ 215
+ +C EF+CDNG+C+ CN +D+C D SDE C +P S C
Sbjct: 3072 EPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINECHDPSISGCDHNCTDTLT 3131
Query: 216 TFPCSGARSTRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAAR 275
+F CS + + +R C + +C + C ++ + GS+ G R
Sbjct: 3132 SFYCSCRPGYKLMSDKRTCVDIDECTE-------MPFVCSQKCENVIGSYICKCAPGYLR 3184
Query: 276 GPSDLHC 282
P C
Sbjct: 3185 EPDGKTC 3191
Score = 47.8 bits (112), Expect = 4e-05
Identities = 31/90 (34%), Positives = 38/90 (42%), Gaps = 17/90 (18%)
Query: 404 CASGRDEQGCPACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCFSCQPGTFHCG 463
CA G + C Q P EG L NN+K C E+ C +F C
Sbjct: 2666 CAPGPNGAEC------QCPHEGNWYLA-------NNRKHCIVDNGER----CGASSFTCS 2708
Query: 464 TNLCIFETWRCDGQEDCQDGSDEHGCLAAV 493
CI E W+CD DC DGSDE + A+
Sbjct: 2709 NGRCISEEWKCDNDNDCGDGSDEMESVCAL 2738
Score = 46.6 bits (109), Expect = 9e-05
Identities = 27/62 (43%), Positives = 35/62 (56%), Gaps = 8/62 (12%)
Query: 211 LCPGGTFPCSGARSTRCLPVERRCDGLQDCGDGSDE-AGCPDLACGRRLGSFY---GSFA 266
+C F C A + +C+P+ +CDG +DC DGSDE A CP C RLG F G+
Sbjct: 3511 MCSSTQFLC--ANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFC--RLGQFQCSDGNCT 3566
Query: 267 SP 268
SP
Sbjct: 3567 SP 3568
Score = 45.8 bits (107), Expect = 1e-04
Identities = 22/50 (44%), Positives = 28/50 (56%), Gaps = 3/50 (6%)
Query: 203 PASEPPGSLCPGGTFPCSGARSTRCLPVERRCDGLQDCGDGSDEAGCPDL 252
P +EPP C +FPC ++ RC+P CDG+ DC D SDE C L
Sbjct: 1017 PTNEPPTEQCGLFSFPC---KNGRCVPNYYLCDGVDDCHDNSDEQLCGTL 1063
Score = 42.7 bits (99), Expect = 0.001
Identities = 16/36 (44%), Positives = 22/36 (61%)
Query: 166 CQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCS 201
C E++C NG C+P C+ D+CGD SDE C+
Sbjct: 3928 CTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGCN 3963
Score = 37.7 bits (86), Expect = 0.041
Identities = 25/94 (26%), Positives = 33/94 (35%), Gaps = 15/94 (15%)
Query: 410 EQGCPACPPDQYPCEGGSGLCYTPADRCNNQKSCP--------------DGADEKNCFSC 455
+ G AC +P S C+ P CP D +E C
Sbjct: 968 QTGSNACNQPTHPNGDCSHFCF-PVPNFQRVCGCPYGMRLASNHLTCEGDPTNEPPTEQC 1026
Query: 456 QPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGC 489
+F C C+ + CDG +DC D SDE C
Sbjct: 1027 GLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLC 1060
>gi|13899255 membrane frizzled-related protein [Homo sapiens]
Length = 579
Score = 125 bits (313), Expect = 2e-28
Identities = 111/394 (28%), Positives = 141/394 (35%), Gaps = 78/394 (19%)
Query: 41 AACSGKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCS 100
+ C G L + RG SP +P YPP T+C W+IQ I + +E C
Sbjct: 142 STCGGLL---SGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCL 198
Query: 101 LDWLLLGPAAPPRQEAFRLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYIRGK 160
D L L P P R+CG PP + H+ + F SD+S G GF Y
Sbjct: 199 FDRLELSPE--PEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGF--GFHAWYQAMA 254
Query: 161 LGQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCS 220
G+ SC DEFRCD CL C+ C DGSDE NCSA S
Sbjct: 255 PGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFS--------------- 299
Query: 221 GARSTRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARGPSDL 280
CG L G+F++P + P L
Sbjct: 300 --------------------------------GCGGNLTGLQGTFSTPSYL--QQYPHQL 325
Query: 281 HCTWLVDTQDSRRVLLQL---------ELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNH 331
CTW + + LQ E + DYV+VYE LL +
Sbjct: 326 LCTWHISVPAGHSIELQFHNFSLEAQDECKF---DYVEVYETSSSGAFSLLG--RFCGAE 380
Query: 332 RPVSLEAAQGRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGC 391
P L ++ L V + + GF+ATY E PCG S S GC
Sbjct: 381 PPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFN---ATENPCGPSELSCQAG----GC 433
Query: 392 FSEPQRCDGWWHCASGRDEQ-GCPACPPDQYPCE 424
CD W C G D+ P PP + CE
Sbjct: 434 KGVQWMCDMWRDCTDGSDDNCSGPLFPPPELACE 467
Score = 45.1 bits (105), Expect = 3e-04
Identities = 43/176 (24%), Positives = 62/176 (35%), Gaps = 12/176 (6%)
Query: 243 GSDEAGC---PDLACGRRLGSFYGSFASPDLFGAARGPSDLHCTWLVDTQDSRRVLLQLE 299
G E+G P CG L G F+SP+ P + HC W + + L++E
Sbjct: 130 GQQESGVSPSPQSTCGGLLSGPRGFFSSPNYPDPY--PPNTHCVWHIQVATDHAIQLKIE 187
Query: 300 LRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQGRLTVAYHARARSAGHGFN 359
+++ L + L P +L L V + + + G GF+
Sbjct: 188 ALSIESVASCLFDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFH 247
Query: 360 ATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQRCDGWWHCASGRDEQGCPA 415
A YQ P S D C CDG+ +CA G DE C A
Sbjct: 248 AWYQAMA-------PGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSA 296
Score = 37.4 bits (85), Expect = 0.053
Identities = 16/38 (42%), Positives = 19/38 (50%)
Query: 454 SCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCLA 491
SC F C +C+ CDG +C DGSDE C A
Sbjct: 259 SCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSA 296
Score = 33.1 bits (74), Expect = 1.0
Identities = 13/33 (39%), Positives = 15/33 (45%)
Query: 455 CQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEH 487
C P C C W CD DC DGSD++
Sbjct: 421 CGPSELSCQAGGCKGVQWMCDMWRDCTDGSDDN 453
>gi|93102379 low density lipoprotein-related protein 1B precursor
[Homo sapiens]
Length = 4599
Score = 122 bits (307), Expect = 1e-27
Identities = 107/412 (25%), Positives = 151/412 (36%), Gaps = 110/412 (26%)
Query: 164 ASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDE------------------GNCSAPAS 205
++C A +FRC KC+P W+C+TVD+CGDGSDE G C+ PA
Sbjct: 3315 SNCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAF 3374
Query: 206 EPPGS---------------LCPGGTFPCSGARSTRCLPVERRCDGLQDCG--------- 241
G +C G F C+ ++ +C+PV RC+G DCG
Sbjct: 3375 ICDGENDCGDNSDELNCDTHVCLSGQFKCT--KNQKCIPVNLRCNGQDDCGDEEDERDCP 3432
Query: 242 -------------------------------DGSDEAGCPDLACGRRLGSFYGSFASPDL 270
D SDEA C CG + PD
Sbjct: 3433 ENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCKNNNCIPDH 3492
Query: 271 FGAARGPSDLHCTWLVDTQDSRRVLLQLE-----------LRLGYDDYVQVYEGLGERGD 319
+ R S C+ D ++ + L+ R D +G ER
Sbjct: 3493 W---RCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDERN- 3548
Query: 320 RLLQTLSYRSNHRPVSLEAAQGRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSS 379
+T + R + G+ A+ + GH + + C P C S
Sbjct: 3549 --CETSCSKDQFR-----CSNGQ---CIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSRE 3598
Query: 380 DSDGGSLGDQGCFSEPQRCDGWWHCASGRDEQGCPA-CPPDQYPCEGGSGLCYTPADRCN 438
GC S +C+G + CA G DE C C DQ+ C+ + C C+
Sbjct: 3599 YI----CASDGCISASLKCNGEYDCADGSDEMDCVTECKEDQFRCKNKAH-CIPIRWLCD 3653
Query: 439 NQKSCPDGADEKNCFS----CQPGTFHCGTNLCIFETWRCDGQEDCQDGSDE 486
C DG+DE+NC C+ F C +LC W CDG++DC D SDE
Sbjct: 3654 GIHDCVDGSDEENCERGGNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDE 3705
Score = 105 bits (262), Expect = 2e-22
Identities = 103/354 (29%), Positives = 127/354 (35%), Gaps = 97/354 (27%)
Query: 166 CQADEFRCDNGKCLPGPWQCNTVDECGDGSDEG--NCSAPASEPPGSLCPGGTFPCSGAR 223
C+A EFRC N C+ W+C+ D+C DGSDE NC CP F C +
Sbjct: 845 CKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCF-------NHSCPDDQFKC---Q 894
Query: 224 STRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARGPSDLHCT 283
+ RC+P CDG DCG DE+ + C R D F G +
Sbjct: 895 NNRCIPKRWLCDGANDCGSNEDES---NQTCTART-------CQVDQFSCGNGRC-IPRA 943
Query: 284 WLVDTQDSRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQGRL 343
WL D +D + GD QT S P Q
Sbjct: 944 WLCDRED-------------------------DCGD---QTDEMASCEFPTCEPLTQ--- 972
Query: 344 TVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQRCD---- 399
V R S+ K +C + CG SD G CF RC
Sbjct: 973 FVCKSGRCISS----------KWHC-DSDDDCGDGSDEVGCV---HSCFDNQFRCSSGRC 1018
Query: 400 --GWWHCASGRD---------------EQGCPA-CPPDQYPCEGGSGLCYTPADRCNNQK 441
G W C D E PA C +++ C G C RC+ +K
Sbjct: 1019 IPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCH-PDGNCVPDLWRCDGEK 1077
Query: 442 SCPDGADEKNCFS----CQPGT-FHC-GTNLCIFETWRCDGQEDCQDGSDEHGC 489
C DG+DEK C C T F C T CI + W CDG DC+D SDE C
Sbjct: 1078 DCEDGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDC 1131
Score = 94.0 bits (232), Expect = 5e-19
Identities = 94/365 (25%), Positives = 130/365 (35%), Gaps = 77/365 (21%)
Query: 165 SCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARS 224
SC D+F+C N +C+P W C+ ++CG DE N + A C F C
Sbjct: 885 SCPDDQFKCQNNRCIPKRWLCDGANDCGSNEDESNQTCTA-----RTCQVDQFSCGNG-- 937
Query: 225 TRCLPVERRCDGLQDCGDGSDE-AGCPDLAC----------GRRLGSFYGSFASPDLFGA 273
RC+P CD DCGD +DE A C C GR + S + + D
Sbjct: 938 -RCIPRAWLCDREDDCGDQTDEMASCEFPTCEPLTQFVCKSGRCISSKWHCDSDDD---C 993
Query: 274 ARGPSDLHCTWLVDTQDSRRVLLQLELRLGYDDYVQVY---EGLGERGDRLLQTLSYRSN 330
G ++ C + R + + +G + GD
Sbjct: 994 GDGSDEVGCV---------HSCFDNQFRCSSGRCIPGHWACDGDNDCGD----------- 1033
Query: 331 HRPVSLEAAQGRLTVAYHARARSAGHGFNATYQVKGYCLP--W----EQPCGSSSDSDG- 383
S EA H+ A G+ F G C+P W E+ C SD G
Sbjct: 1034 ---FSDEAQINCTKEEIHSPAGCNGNEFQC--HPDGNCVPDLWRCDGEKDCEDGSDEKGC 1088
Query: 384 -GSL------------GDQGCFSEPQRCDGWWHCASGRDEQGCPA--CPPDQYPCEGGSG 428
G++ C ++ CDG C DE C + C P ++PC +
Sbjct: 1089 NGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDSFLCGPPKHPCANDTS 1148
Query: 429 LCYTPADRCNNQKSCPDGADEKN-CFSCQPGTFHCGTNLCIFETWR---CDGQEDCQDGS 484
+C P CN +K CPDG+DE C C C +N C R C E Q
Sbjct: 1149 VCLQPEKLCNGKKDCPDGSDEGYLCDECSLNNGGC-SNHCSVVPGRGIVCSCPEGLQLNK 1207
Query: 485 DEHGC 489
D C
Sbjct: 1208 DNKTC 1212
Score = 89.7 bits (221), Expect = 9e-18
Identities = 94/366 (25%), Positives = 130/366 (35%), Gaps = 83/366 (22%)
Query: 165 SCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARS 224
SC+ C N +C+P C+ ++CGD SDE +C S C F C+
Sbjct: 2551 SCRRGFKPCYNRRCIPHGKLCDGENDCGDNSDELDCKV-------STCATVEFRCADG-- 2601
Query: 225 TRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARGPSDLHC-- 282
C+P RC+ DC D SDE C + C FY G R S C
Sbjct: 2602 -TCIPRSARCNQNIDCADASDEKNCNNTDCTH----FYK--LGVKTTGFIRCNSTSLCVL 2654
Query: 283 -TWLVDTQDSRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQG 341
TW+ D G +D G+ D L + + G
Sbjct: 2655 PTWICD---------------GSND-------CGDYSDELKCPVQNKHKCEENYFSCPSG 2692
Query: 342 RLTV----------------AYHARARSAGHGFNATYQ---VKGYCLPWEQPCG---SSS 379
R + +H + + + F + Q K + E CG S
Sbjct: 2693 RCILNTWICDGQKDCEDGRDEFHCDSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDES 2752
Query: 380 DSDGGSL----------GDQGCFSEPQRCDGWWHCASGRDEQGCPACPPDQYPCEGGSGL 429
DS G++ G + C CDG C G DE C P+ C+ + +
Sbjct: 2753 DSICGAITCAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNN-TCDENAFM 2811
Query: 430 CYTPA-----DRCNNQKSCPDGADEK-NCFSCQPGT--FHCGTNLCIFET-WRCDGQEDC 480
C+ C++ C DG+DE C Q GT F C C+ T W+CDG DC
Sbjct: 2812 CHNKVCIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDC 2871
Query: 481 QDGSDE 486
D SDE
Sbjct: 2872 PDHSDE 2877
Score = 85.5 bits (210), Expect = 2e-16
Identities = 90/352 (25%), Positives = 136/352 (38%), Gaps = 41/352 (11%)
Query: 164 ASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGAR 223
++C EFRC +G C+P +CN +C D SDE NC+ L T
Sbjct: 2589 STCATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNS 2648
Query: 224 STRCLPVERRCDGLQDCGDGSDEAGCP------------DLACGRRLGSFYGSFASPDL- 270
++ C+ CDG DCGD SDE CP GR + + + D
Sbjct: 2649 TSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSGRCILNTWICDGQKDCE 2708
Query: 271 FGAARGPSDLHCTWLVDTQDSRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYRSN 330
G D C+W +++ + + + G DD +GL E D + ++ ++
Sbjct: 2709 DGRDEFHCDSSCSWNQFACSAQKCISKHWICDGEDD---CGDGLDE-SDSICGAITCAAD 2764
Query: 331 HRPVSLEAAQG-RLTVAYHARARSAGHGFNATYQVK-GYCLPWEQPCGSSSDSDGGSLGD 388
+ + QG R V H + + ++ C P ++ D + +
Sbjct: 2765 -----MFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAP-----NNTCDENAFMCHN 2814
Query: 389 QGCFSEPQRCDGWWHCASGRDEQ---GCPACPPDQYPCEGGSGLCYTPADRCNNQKSCPD 445
+ C + CD C G DE G C +++ C G L T +C+ CPD
Sbjct: 2815 KVCIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQW-QCDGDFDCPD 2873
Query: 446 GADE----KNC----FSCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGC 489
+DE C SC F C CI CD ++DC DGSDE C
Sbjct: 2874 HSDEAPLNPKCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNC 2925
Score = 84.3 bits (207), Expect = 4e-16
Identities = 41/106 (38%), Positives = 52/106 (49%), Gaps = 5/106 (4%)
Query: 388 DQGCFSEPQRCDGWWHCASGRDEQGCP--ACPPDQYPCEGGSGLCYTPADRCNNQKSCPD 445
+Q C RC+G C DE+ CP +C PD + C+ C + C+ C D
Sbjct: 3406 NQKCIPVNLRCNGQDDCGDEEDERDCPENSCSPDYFQCKTTKH-CISKLWVCDEDPDCAD 3464
Query: 446 GADEKNCF--SCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGC 489
+DE NC +C P F C N CI + WRCD Q DC D SDE C
Sbjct: 3465 ASDEANCDKKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENC 3510
Score = 81.6 bits (200), Expect = 2e-15
Identities = 73/296 (24%), Positives = 111/296 (37%), Gaps = 38/296 (12%)
Query: 163 QASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGA 222
+ SC D+FRC NG+C+P W+C+ ++C G DE +C EP C + C+
Sbjct: 3550 ETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSC-----EPASPTCSSREYICA-- 3602
Query: 223 RSTRCLPVERRCDGLQDCGDGSDEAGC------PDLACGRRLGSFYGSFASPDLFGAARG 276
S C+ +C+G DC DGSDE C C + + + G
Sbjct: 3603 -SDGCISASLKCNGEYDCADGSDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVDG 3661
Query: 277 PSDLHC-----TWLVDTQDSRRVLLQLELRL--GYDDYVQVYEGLGERGDRLL--QTLSY 327
+ +C D L +L + G DD + + + L T +
Sbjct: 3662 SDEENCERGGNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMCVKFLCPSTRPH 3721
Query: 328 RSNHRPVSLEAAQGRLTVAYHARARSAGH-GFNATYQVKGYCLPWEQPCGSSSDSDGGSL 386
R + + L++ Q + H G TY+ + PC D +
Sbjct: 3722 RCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYKAR--------PC----KKDEFAC 3769
Query: 387 GDQGCFSEPQRCDGWWHCASGRDEQGCPACPPDQYPCEGGSGLCYTPADRCNNQKS 442
++ C +CD C G DEQGC P +Y CE C A CN K+
Sbjct: 3770 SNKKCIPMDLQCDRLDDCGDGSDEQGC-RIAPTEYTCEDNVNPCGDDA-YCNQIKT 3823
Score = 80.5 bits (197), Expect = 5e-15
Identities = 39/110 (35%), Positives = 50/110 (45%), Gaps = 5/110 (4%)
Query: 388 DQGCFSEPQRCDGWWHCASGRDEQGCP--ACPPDQYPCEGGSGLCYTPADRCNNQKSCPD 445
+ C + RCD C+ DE+ C C + C G C + C+ C D
Sbjct: 3485 NNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGD--CVSSRFWCDGDFDCAD 3542
Query: 446 GADEKNC-FSCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCLAAVP 494
G+DE+NC SC F C CI W+CDG EDC+ G DE C A P
Sbjct: 3543 GSDERNCETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASP 3592
Score = 77.8 bits (190), Expect = 4e-14
Identities = 44/144 (30%), Positives = 64/144 (44%), Gaps = 23/144 (15%)
Query: 368 CLPWEQPCGSSSDSDGGS----------------LGDQGCFSEPQRCDGWWHCASGRDEQ 411
C+P C S +D S + C S CDG + CA G DE+
Sbjct: 3488 CIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDER 3547
Query: 412 GCP-ACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCF----SCQPGTFHCGTNL 466
C +C DQ+ C G C +C+ + C G DEK+C +C + C ++
Sbjct: 3548 NCETSCSKDQFRCSNGQ--CIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICASDG 3605
Query: 467 CIFETWRCDGQEDCQDGSDEHGCL 490
CI + +C+G+ DC DGSDE C+
Sbjct: 3606 CISASLKCNGEYDCADGSDEMDCV 3629
Score = 73.9 bits (180), Expect = 5e-13
Identities = 44/108 (40%), Positives = 55/108 (50%), Gaps = 10/108 (9%)
Query: 391 CFSEPQRCDGWWHCASGRDE--QGCPA--CPPDQYPCEGGSGLCYTPADRCNNQKSCPDG 446
C + CDG C S DE Q C A C DQ+ C G+G C A C+ + C D
Sbjct: 898 CIPKRWLCDGANDCGSNEDESNQTCTARTCQVDQFSC--GNGRCIPRAWLCDREDDCGDQ 955
Query: 447 ADEK-NCF--SCQPGT-FHCGTNLCIFETWRCDGQEDCQDGSDEHGCL 490
DE +C +C+P T F C + CI W CD +DC DGSDE GC+
Sbjct: 956 TDEMASCEFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCV 1003
Score = 72.8 bits (177), Expect = 1e-12
Identities = 49/169 (28%), Positives = 63/169 (37%), Gaps = 33/169 (19%)
Query: 352 RSAGHGFNATYQVKGYCLPW------EQPCGSSSDSDGGSLG----------DQGCFSEP 395
RS GF Y + C+P E CG +SD + D C
Sbjct: 2550 RSCRRGFKPCYNRR--CIPHGKLCDGENDCGDNSDELDCKVSTCATVEFRCADGTCIPRS 2607
Query: 396 QRCDGWWHCASGRDEQGCPACPPDQYPCEG----------GSGLCYTPADRCNNQKSCPD 445
RC+ CA DE+ C + G + LC P C+ C D
Sbjct: 2608 ARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGD 2667
Query: 446 GADEKNC-----FSCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGC 489
+DE C C+ F C + CI TW CDGQ+DC+DG DE C
Sbjct: 2668 YSDELKCPVQNKHKCEENYFSCPSGRCILNTWICDGQKDCEDGRDEFHC 2716
Score = 67.8 bits (164), Expect = 4e-11
Identities = 37/110 (33%), Positives = 48/110 (43%), Gaps = 8/110 (7%)
Query: 391 CFSEPQRCDGWWHCASGRDEQGCPA-CPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADE 449
C CDG C GRDE C + C +Q+ C C + C+ + C DG DE
Sbjct: 2694 CILNTWICDGQKDCEDGRDEFHCDSSCSWNQFACSAQK--CISKHWICDGEDDCGDGLDE 2751
Query: 450 KN----CFSCQPGTFHC-GTNLCIFETWRCDGQEDCQDGSDEHGCLAAVP 494
+ +C F C G+ C+ W CDG+ DC DGSDE P
Sbjct: 2752 SDSICGAITCAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAP 2801
Score = 65.1 bits (157), Expect = 2e-10
Identities = 34/89 (38%), Positives = 44/89 (49%), Gaps = 5/89 (5%)
Query: 162 GQASCQADEFRCDNGKCLPGP-WQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCS 220
G C +EF C +G+CL WQC+ +C D SDE + P + C F C
Sbjct: 2841 GYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPLN-PKCKSAEQSCNSSFFMC- 2898
Query: 221 GARSTRCLPVERRCDGLQDCGDGSDEAGC 249
++ RC+P CD DCGDGSDE C
Sbjct: 2899 --KNGRCIPSGGLCDNKDDCGDGSDERNC 2925
Score = 65.1 bits (157), Expect = 2e-10
Identities = 32/77 (41%), Positives = 41/77 (53%), Gaps = 5/77 (6%)
Query: 416 CPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKN-C--FSCQPGTFHCGTNLCIFETW 472
C Q+ C+ + C +C+ C DG+DE + C F CQPG F CGT LC +
Sbjct: 3317 CTASQFRCK--TDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAF 3374
Query: 473 RCDGQEDCQDGSDEHGC 489
CDG+ DC D SDE C
Sbjct: 3375 ICDGENDCGDNSDELNC 3391
Score = 63.2 bits (152), Expect = 9e-10
Identities = 36/94 (38%), Positives = 46/94 (48%), Gaps = 9/94 (9%)
Query: 164 ASCQADEFRCD-NGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGT-FPCSG 221
A C +EF+C +G C+P W+C+ +C DGSDE C+ LC T F C
Sbjct: 1051 AGCNGNEFQCHPDGNCVPDLWRCDGEKDCEDGSDEKGCNGTI-----RLCDHKTKFSCWS 1105
Query: 222 ARSTRCLPVERRCDGLQDCGDGSDEAGCPDLACG 255
+ RC+ CDG DC D SDE C CG
Sbjct: 1106 --TGRCINKAWVCDGDIDCEDQSDEDDCDSFLCG 1137
Score = 60.1 bits (144), Expect = 8e-09
Identities = 36/109 (33%), Positives = 49/109 (44%), Gaps = 28/109 (25%)
Query: 397 RCDGWWHCASGRDE-QGCPA--CPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCF 453
+CD C G DE CP C P ++ C G+GLC PA C+ + C D +DE NC
Sbjct: 3335 KCDTVDDCGDGSDEPDDCPEFRCQPGRFQC--GTGLCALPAFICDGENDCGDNSDELNC- 3391
Query: 454 SCQPGTFHCGTNLCIFETW-------------RCDGQEDCQDGSDEHGC 489
T++C+ + RC+GQ+DC D DE C
Sbjct: 3392 ---------DTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDC 3431
Score = 59.7 bits (143), Expect = 1e-08
Identities = 34/92 (36%), Positives = 42/92 (45%), Gaps = 9/92 (9%)
Query: 164 ASCQA-DEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGA 222
+SC A EF C NG+C+ C+ + C D SDE C G PC
Sbjct: 2508 SSCNAYSEFECGNGECIDYQLTCDGIPHCKDKSDEKLLYCENRS-----CRRGFKPCY-- 2560
Query: 223 RSTRCLPVERRCDGLQDCGDGSDEAGCPDLAC 254
+ RC+P + CDG DCGD SDE C C
Sbjct: 2561 -NRRCIPHGKLCDGENDCGDNSDELDCKVSTC 2591
Score = 58.5 bits (140), Expect = 2e-08
Identities = 46/175 (26%), Positives = 58/175 (33%), Gaps = 56/175 (32%)
Query: 368 CLPWEQPCGSSSDSDGGSLGDQGCFSEPQRCDGWWHCASGRDE-------QGC------- 413
C+ C + S+ + G+ C CDG HC DE + C
Sbjct: 2503 CVTKNSSCNAYSEFE---CGNGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPC 2559
Query: 414 --PACPPDQYPCEG-------------------------GSGLCYTPADRCNNQKSCPDG 446
C P C+G G C + RCN C D
Sbjct: 2560 YNRRCIPHGKLCDGENDCGDNSDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADA 2619
Query: 447 ADEKNCFSCQ-----------PGTFHC-GTNLCIFETWRCDGQEDCQDGSDEHGC 489
+DEKNC + G C T+LC+ TW CDG DC D SDE C
Sbjct: 2620 SDEKNCNNTDCTHFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKC 2674
Score = 57.4 bits (137), Expect = 5e-08
Identities = 43/162 (26%), Positives = 59/162 (36%), Gaps = 38/162 (23%)
Query: 365 KGYCLPWE------QPCGSSSDSDGGSLGDQGCFSEPQRCDG------WWHCASGRDEQG 412
K +C+P C SD + G C ++ C+ +W C G D+ G
Sbjct: 3642 KAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADEFLCNNSLCKLHFWVC-DGEDDCG 3700
Query: 413 --------------CPACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCFS---- 454
CP+ P + C +C CN C D +DE +C
Sbjct: 3701 DNSDEAPDMCVKFLCPSTRPHR--CRNNR-ICLQSEQMCNGIDECGDNSDEDHCGGKLTY 3757
Query: 455 ----CQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCLAA 492
C+ F C CI +CD +DC DGSDE GC A
Sbjct: 3758 KARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIA 3799
Score = 57.4 bits (137), Expect = 5e-08
Identities = 31/90 (34%), Positives = 41/90 (45%), Gaps = 18/90 (20%)
Query: 166 CQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSG---- 221
C+ DEF C N KC+P QC+ +D+CGDGSDE C +E C PC
Sbjct: 3762 CKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTE---YTCEDNVNPCGDDAYC 3818
Query: 222 -----ARSTRCLP------VERRCDGLQDC 240
+ RC P R+C+ L +C
Sbjct: 3819 NQIKTSVFCRCKPGFQRNMKNRQCEDLNEC 3848
Score = 52.8 bits (125), Expect = 1e-06
Identities = 20/41 (48%), Positives = 26/41 (63%)
Query: 160 KLGQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNC 200
K + SC + F C NG+C+P C+ D+CGDGSDE NC
Sbjct: 2885 KSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNC 2925
Score = 51.2 bits (121), Expect = 4e-06
Identities = 32/101 (31%), Positives = 45/101 (44%), Gaps = 13/101 (12%)
Query: 163 QASCQADEFRC-DNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSG 221
Q C EF C D+ C+ W C+ +C D SDE + P E CP C G
Sbjct: 29 QQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCP--EEVEIKCPLNHIACLG 86
Query: 222 ARSTRCLPVERRCDGLQDCGDGSDE--------AGCPDLAC 254
+ +C+ + + C+G+ DC DG DE + C L C
Sbjct: 87 --TNKCVHLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNC 125
Score = 47.0 bits (110), Expect = 7e-05
Identities = 20/48 (41%), Positives = 24/48 (50%)
Query: 439 NQKSCPDGADEKNCFSCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDE 486
N +C E C+ G F C CI W+CDG +DC DGSDE
Sbjct: 829 NGTTCTFNPGEALPHICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDE 876
Score = 45.8 bits (107), Expect = 1e-04
Identities = 22/50 (44%), Positives = 27/50 (54%), Gaps = 5/50 (10%)
Query: 442 SCPDG----ADEKNCFS-CQPGTFHCGTNLCIFETWRCDGQEDCQDGSDE 486
+CP AD + C S C F C T+ CI W+CD +DC DGSDE
Sbjct: 3299 ACPTNFYLAADNRTCLSNCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDE 3348
Score = 42.7 bits (99), Expect = 0.001
Identities = 28/87 (32%), Positives = 38/87 (43%), Gaps = 12/87 (13%)
Query: 408 RDEQGCPACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEK--NC-----FSCQPGTF 460
RD+Q C P ++ C C + + C+ CPD +DE C C
Sbjct: 27 RDQQ---LCDPGEFLCHDHV-TCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHI 82
Query: 461 HC-GTNLCIFETWRCDGQEDCQDGSDE 486
C GTN C+ + C+G DC DG DE
Sbjct: 83 ACLGTNKCVHLSQLCNGVLDCPDGYDE 109
Score = 42.7 bits (99), Expect = 0.001
Identities = 20/55 (36%), Positives = 28/55 (50%), Gaps = 3/55 (5%)
Query: 455 CQPGTFHCGTNL-CIFETWRCDGQEDCQDGSDEHGCLAAVPRKVITAALIGSLVC 508
C PG F C ++ C+ ++W CDG DC D SDE L P +V + + C
Sbjct: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDE--SLDTCPEEVEIKCPLNHIAC 84
Score = 30.4 bits (67), Expect = 6.5
Identities = 21/75 (28%), Positives = 28/75 (37%), Gaps = 6/75 (8%)
Query: 174 DNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPG------SLCPGGTFPCSGARSTRC 227
D CL CN +C DGSDEG S G S+ PG CS +
Sbjct: 1146 DTSVCLQPEKLCNGKKDCPDGSDEGYLCDECSLNNGGCSNHCSVVPGRGIVCSCPEGLQL 1205
Query: 228 LPVERRCDGLQDCGD 242
+ C+ + C +
Sbjct: 1206 NKDNKTCEIVDYCSN 1220
>gi|4507157 sortilin-related receptor containing LDLR class A repeats
preproprotein [Homo sapiens]
Length = 2214
Score = 121 bits (304), Expect = 2e-27
Identities = 100/366 (27%), Positives = 137/366 (37%), Gaps = 55/366 (15%)
Query: 165 SCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEG--NCSAPASEPPGSLCPGGTFPCSGA 222
+C+A F+C NG C+P W C+ +C DGSDE NC + G CP GT
Sbjct: 1198 TCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCN---GFRCPNGT------ 1248
Query: 223 RSTRCLPVERRCDGLQDCGDGSDEAGCP-------DLACGRRLGSFYGSFASPDLFGAAR 275
C+P + CDGL+DC DGSDE C D C R + S + R
Sbjct: 1249 ----CIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGII-QCR 1303
Query: 276 GPSDLHCTWLVDTQDSRRVLLQLELRLGYDDYVQV-----YEGLGERGDRLLQTLSYRSN 330
SD + +QD + E + V + +G+ + GD +
Sbjct: 1304 DGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPT 1363
Query: 331 HRPVSLEAAQGRLTVAYHA-------RARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDG 383
P Q R + R G + + LP+ P S+ +
Sbjct: 1364 EAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNY 1423
Query: 384 GSLGDQGCFSEPQRCDGWWHCASGRDEQGCP--------ACPPDQYPCEGGSGLCYTPA- 434
C + CDG+ CA G DE+ CP + P C+ C+ P
Sbjct: 1424 YRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKT 1483
Query: 435 -----DRCNNQKSCPDGADEKNC-----FSCQPGTFHC-GTNLCIFETWRCDGQEDCQDG 483
RC+ + C DG DE NC +C F C CI + RCDG DC D
Sbjct: 1484 CIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDE 1543
Query: 484 SDEHGC 489
SDE C
Sbjct: 1544 SDEKAC 1549
Score = 113 bits (283), Expect = 6e-25
Identities = 96/370 (25%), Positives = 136/370 (36%), Gaps = 102/370 (27%)
Query: 150 QGFRLSYIRGKLGQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPG 209
QG++L + +C +++RC NG C+ W C+ ++CGD SDE NC P
Sbjct: 1062 QGYQLKNNTCVKEENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNC-------PT 1114
Query: 210 SLCPGGT-FPCSGARSTRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASP 268
++C T F C S C+P+ +CD DCGD SDE+ C C
Sbjct: 1115 TICDLDTQFRCQ--ESGTCIPLSYKCDLEDDCGDNSDESHCEMHQC------------RS 1160
Query: 269 DLFGAARGPSDLHCTWLVDTQDSRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYR 328
D + + G + +W+ D GD + S
Sbjct: 1161 DEYNCSSGMC-IRSSWVCD------------------------------GDNDCRDWSDE 1189
Query: 329 SNHRPVSLEAAQGRLTVAYHARARSAGHGFNATYQVK-GYCLPWEQPCGSSSDSDGGSLG 387
+N T YH S +Q + G+C+P C +D GS
Sbjct: 1190 AN------------CTAIYHTCEAS-------NFQCRNGHCIPQRWACDGDTDCQDGSDE 1230
Query: 388 DQ---------------GCFSEPQRCDGWWHCASGRDEQGC-PACPP-DQYPCEGGSGLC 430
D C + CDG C+ G DEQ C P C + C+ C
Sbjct: 1231 DPVNCEKKCNGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQ-QC 1289
Query: 431 YTPADRCNNQKSCPDGADEKNCFS-----------CQPGTFHCGTNLCIFETWRCDGQED 479
+ C+ C DG+DE F+ C F C +CI W+CDG +D
Sbjct: 1290 LFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDD 1349
Query: 480 CQDGSDEHGC 489
C D SDE C
Sbjct: 1350 CGDYSDEANC 1359
Score = 74.7 bits (182), Expect = 3e-13
Identities = 37/95 (38%), Positives = 51/95 (53%), Gaps = 8/95 (8%)
Query: 162 GQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNC----SAPASEPPGSL--CPGG 215
G ++C + +RC +G C+ W C+ +C DGSDE C + A+ P L C
Sbjct: 1415 GPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRF 1474
Query: 216 TFPCSGARSTRCLPVERRCDGLQDCGDGSDEAGCP 250
F C ++ C+P +RCDG QDC DG DEA CP
Sbjct: 1475 EFECHQPKT--CIPNWKRCDGHQDCQDGRDEANCP 1507
Score = 73.6 bits (179), Expect = 7e-13
Identities = 39/118 (33%), Positives = 55/118 (46%), Gaps = 18/118 (15%)
Query: 391 CFSEPQRCDG-------WW-----HCASGRDEQGCPA--CPPD-QYPCEGGSGLCYTPAD 435
C RC WW C DE+ CP C D Q+ C+ SG C +
Sbjct: 1078 CLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQE-SGTCIPLSY 1136
Query: 436 RCNNQKSCPDGADEKNC--FSCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCLA 491
+C+ + C D +DE +C C+ ++C + +CI +W CDG DC+D SDE C A
Sbjct: 1137 KCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTA 1194
Score = 60.5 bits (145), Expect = 6e-09
Identities = 31/87 (35%), Positives = 40/87 (45%), Gaps = 7/87 (8%)
Query: 166 CQADEFRCDNGK-CLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARS 224
C EF C K C+P +C+ +C DG DE NC ++ C F C +
Sbjct: 1471 CDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHST----LTCMSREFQCEDGEA 1526
Query: 225 TRCLPVERRCDGLQDCGDGSDEAGCPD 251
C+ + RCDG DC D SDE C D
Sbjct: 1527 --CIVLSERCDGFLDCSDESDEKACSD 1551
Score = 55.8 bits (133), Expect = 1e-07
Identities = 47/191 (24%), Positives = 64/191 (33%), Gaps = 65/191 (34%)
Query: 363 QVKGYCLPW------EQPCGSSSD----------SDGGSLGDQGCFSEPQRCDGWWHCAS 406
Q G C+P E CG +SD SD + C CDG C
Sbjct: 1126 QESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRD 1185
Query: 407 GRDEQGCPA----------------CPPDQYPCEGGS----------------------- 427
DE C A C P ++ C+G +
Sbjct: 1186 WSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNGFRCP 1245
Query: 428 -GLCYTPADRCNNQKSCPDGADEKNCFSCQPGTFHC------GTNLCIFETWRCDGQEDC 480
G C + C+ + C DG+DE++C +P H C+F + CDG C
Sbjct: 1246 NGTCIPSSKHCDGLRDCSDGSDEQHC---EPLCTHFMDFVCKNRQQCLFHSMVCDGIIQC 1302
Query: 481 QDGSDEHGCLA 491
+DGSDE A
Sbjct: 1303 RDGSDEDAAFA 1313
Score = 39.7 bits (91), Expect = 0.011
Identities = 20/53 (37%), Positives = 22/53 (41%), Gaps = 6/53 (11%)
Query: 443 CPDGADEKN--CF----SCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGC 489
CP G KN C +C + C CI W CD DC D SDE C
Sbjct: 1060 CPQGYQLKNNTCVKEENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNC 1112
>gi|134031945 SCO-spondin [Homo sapiens]
Length = 5147
Score = 117 bits (292), Expect = 5e-26
Identities = 117/365 (32%), Positives = 138/365 (37%), Gaps = 76/365 (20%)
Query: 162 GQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSG 221
G+A CQ +NG C+P W C+ D+CGDGSDE C+AP C G CS
Sbjct: 1379 GEALCQ------ENGHCVPHGWLCDNQDDCGDGSDEEGCAAPG-------CGEGQMTCS- 1424
Query: 222 ARSTRCLPVERRCDGLQDCGDGSDEAG--CPD--LAC--GRRLGSFYGSFASPDLFGAAR 275
S CLP+ CD DCGDG+DE CP LAC GR L PD AA
Sbjct: 1425 --SGHCLPLALLCDRQDDCGDGTDEPSYPCPQGLLACADGRCLPPALLCDGHPDCLDAAD 1482
Query: 276 GPSDLHCTWLVDTQDS---RRVLLQLELRLG-YDDYVQVYEGLGERGDRLLQT--LSYRS 329
S L V + S L ++L G +D EG G L T S
Sbjct: 1483 EESCLGQVTCVPGEVSCVDGTCLGAIQLCDGVWDCPDGADEGPGHCPLPSLPTPPASTLP 1542
Query: 330 NHRPVSLEAAQGRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQ 389
P SL+ A L A A C P+E CGS
Sbjct: 1543 GPSPGSLDTASSPLASASPAPP----------------CGPFEFRCGSGE---------- 1576
Query: 390 GCFSEPQRCDGWWHCASGRDEQGCPA-CPPDQYPCEGGSGLCYTPADRCNNQKSCPDGAD 448
C RCD CA G DE+GC C P PC G C +P C+ + CPDG+D
Sbjct: 1577 -CTPRGWRCDQEEDCADGSDERGCGGPCAPHHAPCARGPH-CVSPEQLCDGVRQCPDGSD 1634
Query: 449 E-------------KNCFSCQPGTFHCGTNLCIFETWRCDGQEDC------QDGSDEHGC 489
E N + C CI CDGQ DC +E GC
Sbjct: 1635 EGPDACGGLPALGGPNRTGLPCPEYTCPNGTCIGFQLVCDGQPDCGRPGQVGPSPEEQGC 1694
Query: 490 LAAVP 494
A P
Sbjct: 1695 GAWGP 1699
Score = 64.7 bits (156), Expect = 3e-10
Identities = 49/146 (33%), Positives = 60/146 (41%), Gaps = 40/146 (27%)
Query: 161 LGQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDE--GNCSAPA-SEPPGSLCPG--- 214
LGQ +C E C +G CL C+ V +C DG+DE G+C P+ PP S PG
Sbjct: 1487 LGQVTCVPGEVSCVDGTCLGAIQLCDGVWDCPDGADEGPGHCPLPSLPTPPASTLPGPSP 1546
Query: 215 -----GTFPCSGAR-------------STRCLPVERRCDGLQDCGDGSDEAGCPDLACGR 256
+ P + A S C P RCD +DC DGSDE GC
Sbjct: 1547 GSLDTASSPLASASPAPPCGPFEFRCGSGECTPRGWRCDQEEDCADGSDERGC------- 1599
Query: 257 RLGSFYGSFASPDLFGAARGPSDLHC 282
G +P ARGP HC
Sbjct: 1600 ------GGPCAPHHAPCARGP---HC 1616
Score = 58.2 bits (139), Expect = 3e-08
Identities = 34/114 (29%), Positives = 44/114 (38%), Gaps = 38/114 (33%)
Query: 416 CPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCFS--------------------- 454
C P Q PCE C A C+ ++ C DG+DE++C
Sbjct: 2391 CGPGQTPCEVLG--CVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVPFM 2448
Query: 455 ---------------CQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCLAAV 493
C P CG+ C+ RCD + DCQDGSDE GC+ V
Sbjct: 2449 MPTMALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPDCQDGSDEDGCVDCV 2502
Score = 53.5 bits (127), Expect = 7e-07
Identities = 47/159 (29%), Positives = 62/159 (38%), Gaps = 38/159 (23%)
Query: 366 GYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQRC-----DGWWHCASGRDEQGCPACPPDQ 420
G+ + W S +GG + + + P C + WHC +GC CP
Sbjct: 1260 GHHVRWRSQELCSLQCEGGQVYEACGPTCPPTCHEQHPEPGWHCQVVACVEGC-FCPEGT 1318
Query: 421 YPCEGGSGLCYTPAD-RCN-NQKSCPDGA----DEKNCFSCQPGTFHCG----------- 463
GG+ C PA C + S P G+ D NC +CQ G +HCG
Sbjct: 1319 L-LHGGA--CLEPASCPCEWGRNSFPPGSVLQKDCGNC-TCQEGQWHCGGDGGHCEELVP 1374
Query: 464 -----------TNLCIFETWRCDGQEDCQDGSDEHGCLA 491
C+ W CD Q+DC DGSDE GC A
Sbjct: 1375 ACAEGEALCQENGHCVPHGWLCDNQDDCGDGSDEEGCAA 1413
Score = 51.6 bits (122), Expect = 3e-06
Identities = 36/120 (30%), Positives = 45/120 (37%), Gaps = 30/120 (25%)
Query: 159 GKLGQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSA---------------- 202
G C + C+ C+ C+ ++C DGSDE +C+
Sbjct: 2384 GPFPPVQCGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAAS 2443
Query: 203 ------PASEPPG-----SLCPGGTFPCSGARSTRCLPVERRCDGLQDCGDGSDEAGCPD 251
P PG +LC C S CL ERRCD DC DGSDE GC D
Sbjct: 2444 TVPFMMPTMALPGLPASRALCSPSQLSCG---SGECLSAERRCDLRPDCQDGSDEDGCVD 2500
Score = 46.2 bits (108), Expect = 1e-04
Identities = 30/102 (29%), Positives = 36/102 (35%), Gaps = 38/102 (37%)
Query: 390 GCFSEPQRCDGWWHCASGRDEQGC-----------PA----------------------- 415
GC + Q CDG C G DE+ C PA
Sbjct: 2402 GCVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVPFMMPTMALPGLPASR 2461
Query: 416 --CPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCFSC 455
C P Q C GSG C + RC+ + C DG+DE C C
Sbjct: 2462 ALCSPSQLSC--GSGECLSAERRCDLRPDCQDGSDEDGCVDC 2501
Score = 44.3 bits (103), Expect = 4e-04
Identities = 28/70 (40%), Positives = 34/70 (48%), Gaps = 5/70 (7%)
Query: 207 PPGSLCPGGTFPCSGARSTRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFA 266
PP LCPG C+ S C+ CDG+ DC DGSDE GC L G G F+ +
Sbjct: 2229 PPAPLCPGVGLRCA---SGECVLRGGPCDGVLDCEDGSDEEGCVLLPEG--TGRFHSTAK 2283
Query: 267 SPDLFGAARG 276
+ L A G
Sbjct: 2284 TLALSSAQPG 2293
Score = 43.1 bits (100), Expect = 0.001
Identities = 78/338 (23%), Positives = 116/338 (34%), Gaps = 70/338 (20%)
Query: 155 SYIRGKLGQASCQADEFRCDNGKC-LPGPWQC-NTVDECGDGSDEGN------CSAPASE 206
S+++G+ + SC + C++ +C +P W ++ +C GN C A A
Sbjct: 4227 SWLQGECQRCSCTPEGVICEDTECAVPEAWTLWSSWSDCPVSCGGGNQVRTRACRAAAPH 4286
Query: 207 PPGSLCPGGTFPCSGARSTRCLPVERRCDG------LQDCGDG--SDEAGCPDLACGRRL 258
C G P + R C + C + CG G S CP L +
Sbjct: 4287 HRSPPCLG---PDTQTRQQPCPGLLEACSWGPWGPCSRSCGPGLASRSGSCPCL-MAKAD 4342
Query: 259 GSFYGSFASPDLFGAARGPSDLHC---TWLVDTQDSRRVLLQLELRLGYDDYVQVYEGLG 315
+ +F D G GP C +W T+ S RVL+Q R ++G
Sbjct: 4343 PTCNSTFLHLDTQGCYSGPCPEECVWSSWSSWTRCSCRVLVQQRYR---------HQGPA 4393
Query: 316 ERGDRLLQTLSYRSNH-RPVSL-EAAQGRLTVAYHARARSAGHGFNATYQVKGYCLPWEQ 373
RG R + H RP + ++ T + A +
Sbjct: 4394 SRGARAGAPCTRLDGHFRPCLISNCSEDSCTPPFEFHACGS------------------- 4434
Query: 374 PCGSSSDSDGGSLGDQGCFSEPQRCDGWWHCASGRDEQGCPACPPDQYPC----EGGSGL 429
PC + L Q C P C +C G EQ PP++ C G+G+
Sbjct: 4435 PCAGLCAT---HLSHQLCQDLPP-CQPGCYCPKGLLEQAGGCIPPEECNCWHTSAAGAGM 4490
Query: 430 CYTPADRCNNQKSCPDGADEKNCFSCQPGTFHCGTNLC 467
P DR Q C K C C+ G HC + C
Sbjct: 4491 TLAPGDRL--QLGC------KEC-ECRRGELHCTSQGC 4519
Score = 40.4 bits (93), Expect = 0.006
Identities = 17/46 (36%), Positives = 23/46 (50%), Gaps = 10/46 (21%)
Query: 455 CQPGT----------FHCGTNLCIFETWRCDGQEDCQDGSDEHGCL 490
C+PG+ C + C+ CDG DC+DGSDE GC+
Sbjct: 2224 CEPGSPPAPLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGCV 2269
Score = 36.2 bits (82), Expect = 0.12
Identities = 25/91 (27%), Positives = 32/91 (35%), Gaps = 10/91 (10%)
Query: 170 EFRCDNGKCLPGPWQCNTVDECG------DGSDEGNCSAPASEPPGSLCPGGTFPCSGAR 223
E+ C NG C+ C+ +CG +E C A P C P R
Sbjct: 1658 EYTCPNGTCIGFQLVCDGQPDCGRPGQVGPSPEEQGCGAWGPWSPWGPCSRTCGPWGQGR 1717
Query: 224 STRCLP----VERRCDGLQDCGDGSDEAGCP 250
S RC P V + C G + A CP
Sbjct: 1718 SRRCSPLGLLVLQNCPGPEHQSQACFTAACP 1748
Score = 33.1 bits (74), Expect = 1.0
Identities = 14/35 (40%), Positives = 19/35 (54%)
Query: 166 CQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNC 200
C RC +G+C+ C+ V +C DGSDE C
Sbjct: 2234 CPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGC 2268
Score = 32.3 bits (72), Expect = 1.7
Identities = 17/52 (32%), Positives = 20/52 (38%), Gaps = 11/52 (21%)
Query: 365 KGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQRCDGWWHCASGRDEQGCPAC 416
+ C P + CGS C S +RCD C G DE GC C
Sbjct: 2461 RALCSPSQLSCGSGE-----------CLSAERRCDLRPDCQDGSDEDGCVDC 2501
Score = 32.0 bits (71), Expect = 2.2
Identities = 18/50 (36%), Positives = 21/50 (42%), Gaps = 4/50 (8%)
Query: 414 PACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCFSCQPGT--FH 461
P CP C SG C C+ C DG+DE+ C GT FH
Sbjct: 2232 PLCPGVGLRC--ASGECVLRGGPCDGVLDCEDGSDEEGCVLLPEGTGRFH 2279
Score = 31.6 bits (70), Expect = 2.9
Identities = 39/124 (31%), Positives = 48/124 (38%), Gaps = 29/124 (23%)
Query: 136 WIFFHSDASSSGQAQGF-RLSYIRGKLGQASCQADEFR---CDNGKC-LPGPWQ------ 184
W + S + S G F R +R L SC D FR C C + G W
Sbjct: 2506 WSVWSSCSRSCGLGLTFQRQELLRPPLPGGSCPRDRFRSQSCFVQACPVAGAWAMWEAWG 2565
Query: 185 -CNTVDECGDG--SDEGNCSAPASEPPGSLCPGGTFPCSGARSTRCLPVERRCDGLQDCG 241
C+ CG G S + +C P PP + G PC GA ER GLQ C
Sbjct: 2566 PCSV--SCGGGHQSRQRSCVDP---PPKN----GGAPCPGASQ------ERAPCGLQPCS 2610
Query: 242 DGSD 245
G+D
Sbjct: 2611 GGTD 2614
>gi|157384998 low density lipoprotein receptor-related protein 4
[Homo sapiens]
Length = 1905
Score = 103 bits (257), Expect = 6e-22
Identities = 99/347 (28%), Positives = 128/347 (36%), Gaps = 50/347 (14%)
Query: 163 QASCQADEFRC-----DNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTF 217
+ +C F C C+P WQC+ ++CGD SDE C P P C G
Sbjct: 24 ECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPTCSPLDFHCDNG-- 81
Query: 218 PCSGARSTRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARGP 277
+C+ CDG DC D SDE CP C + L+
Sbjct: 82 --------KCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIRSLWHC---D 130
Query: 278 SDLHCTWLVDTQDSRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYRSN------H 331
D C D Q R E R D + E GD + S N
Sbjct: 131 GDNDCGDNSDEQCDMRKCSDKEFRCS--DGSCIAEHWYCDGDTDCKDGSDEENCPSAVPA 188
Query: 332 RPVSLE---AAQGRLTV-AYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLG 387
P +LE A GR + YH G + + C QPC S G +
Sbjct: 189 PPCNLEEFQCAYGRCILDIYHCD----GDDDCGDWSDESDCSS-HQPCRS-----GEFMC 238
Query: 388 DQG-CFSEPQRCDGWWHCASGRDEQGCPA--CPPDQYPCEGGSGLCYTPADRCNNQKSCP 444
D G C + RCDG C DE+ C C +Q+ C SG C + RC+ + C
Sbjct: 239 DSGLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRCH--SGRCVRLSWRCDGEDDCA 296
Query: 445 DGADEKNCFS-----CQPGTFHCGTNLCIFETWRCDGQEDCQDGSDE 486
D +DE+NC + C F C CI + C+G DC D SDE
Sbjct: 297 DNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDE 343
Score = 92.4 bits (228), Expect = 1e-18
Identities = 54/146 (36%), Positives = 66/146 (45%), Gaps = 21/146 (14%)
Query: 368 CLP--WE----QPCGSSSDSDGGSLG---------DQG-CFSEPQRCDGWWHCASGRDEQ 411
C+P W+ CG SD DG L D G C CDG C DEQ
Sbjct: 44 CIPAQWQCDGDNDCGDHSDEDGCILPTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQ 103
Query: 412 GCPA--CPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEK-NCFSCQPGTFHCGTNLCI 468
CP C D++PC+ +G C C+ C D +DE+ + C F C CI
Sbjct: 104 DCPPRECEEDEFPCQ--NGYCIRSLWHCDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCI 161
Query: 469 FETWRCDGQEDCQDGSDEHGCLAAVP 494
E W CDG DC+DGSDE C +AVP
Sbjct: 162 AEHWYCDGDTDCKDGSDEENCPSAVP 187
Score = 88.6 bits (218), Expect = 2e-17
Identities = 51/152 (33%), Positives = 66/152 (43%), Gaps = 26/152 (17%)
Query: 366 GYCLP--W----EQPCGSSSDSDGGS---------LGDQGCFSEPQRCDGWWHCASGRDE 410
GYC+ W + CG +SD D C +E CDG C G DE
Sbjct: 120 GYCIRSLWHCDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDE 179
Query: 411 QGCPACPP------DQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCFSCQP---GTFH 461
+ CP+ P +++ C G C C+ C D +DE +C S QP G F
Sbjct: 180 ENCPSAVPAPPCNLEEFQC--AYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFM 237
Query: 462 CGTNLCIFETWRCDGQEDCQDGSDEHGCLAAV 493
C + LCI WRCDG DC D SDE C ++
Sbjct: 238 CDSGLCINAGWRCDGDADCDDQSDERNCTTSM 269
Score = 71.6 bits (174), Expect = 3e-12
Identities = 36/94 (38%), Positives = 49/94 (52%), Gaps = 9/94 (9%)
Query: 166 CQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARST 225
C A++FRC +G+C+ W+C+ D+C D SDE NC S C F C
Sbjct: 270 CTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENCENTGSPQ----CALDQFLCWNG--- 322
Query: 226 RCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLG 259
RC+ + C+G+ DCGD SDE+ P C R G
Sbjct: 323 RCIGQRKLCNGVNDCGDNSDES--PQQNCRPRTG 354
Score = 64.3 bits (155), Expect = 4e-10
Identities = 36/109 (33%), Positives = 43/109 (39%), Gaps = 16/109 (14%)
Query: 383 GGSLGDQGCFSEPQRCDGWWHCASGRDEQGCPACPPDQYPCEGGSGLCYTPADRCNNQKS 442
G L G S P+ G H G C P Q+ C+G
Sbjct: 11 GALLCAHGLASSPECACGRSHFTCAVSALGECTCIPAQWQCDG--------------DND 56
Query: 443 CPDGADEKNCF--SCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGC 489
C D +DE C +C P FHC CI +W CDG DC+D SDE C
Sbjct: 57 CGDHSDEDGCILPTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDC 105
Score = 47.8 bits (112), Expect = 4e-05
Identities = 28/82 (34%), Positives = 35/82 (42%), Gaps = 9/82 (10%)
Query: 391 CFSEPQRCDGWWHCASGRDEQGC-----PACPPDQYPCEGGSGLCYTPADRCNNQKSCPD 445
C RCDG CA DE+ C P C DQ+ C +G C CN C D
Sbjct: 282 CVRLSWRCDGEDDCADNSDEENCENTGSPQCALDQFLC--WNGRCIGQRKLCNGVNDCGD 339
Query: 446 GADEKNCFSCQP--GTFHCGTN 465
+DE +C+P G +C N
Sbjct: 340 NSDESPQQNCRPRTGEENCNVN 361
Score = 45.1 bits (105), Expect = 3e-04
Identities = 33/109 (30%), Positives = 44/109 (40%), Gaps = 9/109 (8%)
Query: 162 GQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEG---NCSAPASEPPGSLCPGGTFP 218
G C D+F C NG+C+ CN V++CGD SDE NC E ++ GG
Sbjct: 308 GSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQ 367
Query: 219 ----CSGARSTRCLPVERRCDGLQDCGDGSD--EAGCPDLACGRRLGSF 261
GA C R + C D ++ E G C G+F
Sbjct: 368 KCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCTNSEGAF 416
Score = 42.0 bits (97), Expect = 0.002
Identities = 20/49 (40%), Positives = 26/49 (53%), Gaps = 2/49 (4%)
Query: 442 SCPDGADEKNCFSCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCL 490
S P+ A ++ F+C G CI W+CDG DC D SDE GC+
Sbjct: 21 SSPECACGRSHFTCAVSAL--GECTCIPAQWQCDGDNDCGDHSDEDGCI 67
>gi|11415040 matriptase [Homo sapiens]
Length = 855
Score = 99.4 bits (246), Expect = 1e-20
Identities = 67/245 (27%), Positives = 105/245 (42%), Gaps = 49/245 (20%)
Query: 37 VPALAACSGKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEE- 95
+P +++C G+L + +G SP +P +YPP +C+W I+ + + F+ F + E
Sbjct: 334 LPRMSSCGGRLRK---AQGTFNSPYYPGHYPPNIDCTWNIEVPNNQHVKVRFKFFYLLEP 390
Query: 96 ---SHQCSLDWLLLGPAAPPRQEAFRLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGF 152
+ C D++ + + CG S + + + FHSD S + GF
Sbjct: 391 GVPAGTCPKDYVEINGE--------KYCGERSQFVVTSNSNKITVRFHSDQSYTDT--GF 440
Query: 153 RLSYIRGKLGQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPA-------- 204
Y+ + +F C G+C+ +C+ +C D SDE NCS A
Sbjct: 441 LAEYL--SYDSSDPCPGQFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKN 498
Query: 205 -------------------SEPPGSLCPGGTFPCSGARSTRCLPVERRCDGLQDCGDGSD 245
S+ G CP TF CS +CL ++C+G DCGDGSD
Sbjct: 499 KFCKPLFWVCDSVNDCGDNSDEQGCSCPAQTFRCSNG---KCLSKSQQCNGKDDCGDGSD 555
Query: 246 EAGCP 250
EA CP
Sbjct: 556 EASCP 560
Score = 94.0 bits (232), Expect = 5e-19
Identities = 69/249 (27%), Positives = 107/249 (42%), Gaps = 40/249 (16%)
Query: 253 ACGRRLGSFYGSFASPDLFGAARGPSDLHCTWLVDTQDSRRVLLQLE----LRLGYD--- 305
+CG RL G+F SP + P ++ CTW ++ +++ V ++ + L G
Sbjct: 339 SCGGRLRKAQGTFNSP--YYPGHYPPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGT 396
Query: 306 ---DYVQVYEGLGER--GDRLLQTLSYRSNHRPVSLEAAQGRLTVAYHARARSAGHGFNA 360
DYV++ GE+ G+R ++ SN ++TV +H+ GF A
Sbjct: 397 CPKDYVEIN---GEKYCGERSQFVVTSNSN-----------KITVRFHSDQSYTDTGFLA 442
Query: 361 TYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQRCDGWWHCASGRDEQGCPACPPDQ 420
Y PC G C + RCDGW C DE C Q
Sbjct: 443 EY----LSYDSSDPCPGQFTCRTGR-----CIRKELRCDGWADCTDHSDELNCSCDAGHQ 493
Query: 421 YPCEGGSGLCYTPADRCNNQKSCPDGADEKNCFSCQPGTFHCGTNLCIFETWRCDGQEDC 480
+ C+ + C C++ C D +DE+ C SC TF C C+ ++ +C+G++DC
Sbjct: 494 FTCK--NKFCKPLFWVCDSVNDCGDNSDEQGC-SCPAQTFRCSNGKCLSKSQQCNGKDDC 550
Query: 481 QDGSDEHGC 489
DGSDE C
Sbjct: 551 GDGSDEASC 559
Score = 74.3 bits (181), Expect = 4e-13
Identities = 42/94 (44%), Positives = 50/94 (53%), Gaps = 11/94 (11%)
Query: 165 SCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPC-SGAR 223
SC A FRC NGKCL QCN D+CGDGSDE +C + C T+ C +G
Sbjct: 524 SCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASC----PKVNVVTCTKHTYRCLNGLC 579
Query: 224 STRCLPVERRCDGLQDCGDGSDEAGCPDLACGRR 257
++ P CDG +DC DGSDE C CG R
Sbjct: 580 LSKGNP---ECDGKEDCSDGSDEKDCD---CGLR 607
Score = 38.9 bits (89), Expect = 0.018
Identities = 17/42 (40%), Positives = 25/42 (59%), Gaps = 1/42 (2%)
Query: 160 KLGQASCQADEFRCDNGKCL-PGPWQCNTVDECGDGSDEGNC 200
K+ +C +RC NG CL G +C+ ++C DGSDE +C
Sbjct: 561 KVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDC 602
Score = 37.4 bits (85), Expect = 0.053
Identities = 19/73 (26%), Positives = 39/73 (53%), Gaps = 4/73 (5%)
Query: 59 SPAWPLN-YPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSLDWLLLGPAAPPRQ--E 115
+P +P + YP C W ++GD +++++FR+FD+ + D + + P +
Sbjct: 230 TPGFPDSPYPAHARCQWALRGDADSVLSLTFRSFDLASCDERGSDLVTVYNTLSPMEPHA 289
Query: 116 AFRLCGSAIPPAF 128
+LCG+ PP++
Sbjct: 290 LVQLCGT-YPPSY 301
>gi|4504975 low density lipoprotein receptor precursor [Homo
sapiens]
Length = 860
Score = 94.7 bits (234), Expect = 3e-19
Identities = 46/116 (39%), Positives = 63/116 (54%), Gaps = 8/116 (6%)
Query: 375 CGSSSDSDGGSLGDQGCFSEPQRCDGWWHCASGRDEQGCP--ACPPDQYPCEGGSGLCYT 432
C S S GG + C + RCDG C +G DEQGCP C D++ C G C +
Sbjct: 68 CKSGDFSCGGRVNR--CIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGK--CIS 123
Query: 433 PADRCNNQKSCPDGADEKNC--FSCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDE 486
C++ + C DG+DE +C +C P +F C ++ CI + W CD DC+DGSDE
Sbjct: 124 RQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDE 179
Score = 87.8 bits (216), Expect = 3e-17
Identities = 93/378 (24%), Positives = 129/378 (34%), Gaps = 118/378 (31%)
Query: 166 CQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARST 225
C+ +EF+C +GKC+ W C+ EC DGSDE + + C G F C G R
Sbjct: 27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVT-----CKSGDFSCGG-RVN 80
Query: 226 RCLPVERRCDGLQDCG---------------------------------------DGSDE 246
RC+P RCDG DC DGSDE
Sbjct: 81 RCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDE 140
Query: 247 AGCPDLACGRRLGSFYGSFASPDLFGAARGPSDLHCTWLVDTQDSRRVLLQLELRLGYDD 306
A CP L CG S P L+ P D +D G D+
Sbjct: 141 ASCPVLTCGPASFQCNSSTCIPQLWACDNDP---------DCED------------GSDE 179
Query: 307 YVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQGRLTVAYHARARSAGHGFNATYQVKG 366
+ Q GL ++ + P S +H +G +++++ G
Sbjct: 180 WPQRCRGL----------YVFQGDSSPCS--------AFEFHC---LSGECIHSSWRCDG 218
Query: 367 YCLPWEQPCGSSSDSDGGSL----------GDQGCFSEPQRCDGWWHCASGRDEQGC--- 413
C SD + ++ D C ++CD + C DE GC
Sbjct: 219 -----GPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNV 273
Query: 414 PACP-PDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCFSCQPGTFHCGTNLCIFETW 472
C P+++ C SG C T CN + C D +DE CGTN C+
Sbjct: 274 TLCEGPNKFKCH--SGECITLDKVCNMARDCRDWSDEP--------IKECGTNECLDNNG 323
Query: 473 RCDGQEDCQDGSDEHGCL 490
C C D + CL
Sbjct: 324 GC--SHVCNDLKIGYECL 339
Score = 80.5 bits (197), Expect = 5e-15
Identities = 52/159 (32%), Positives = 61/159 (38%), Gaps = 34/159 (21%)
Query: 368 CLPWEQPCGSSSDSDGGSLGDQGC-----------------FSEPQRCDGWWHCASGRDE 410
C+P C D D GS +QGC S CD C G DE
Sbjct: 82 CIPQFWRCDGQVDCDNGS-DEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDE 140
Query: 411 QGCPA--CPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADE--KNCFS----------CQ 456
CP C P + C S C C+N C DG+DE + C C
Sbjct: 141 ASCPVLTCGPASFQCN--SSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCS 198
Query: 457 PGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCLAAVPR 495
FHC + CI +WRCDG DC+D SDE C A R
Sbjct: 199 AFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCR 237
Score = 66.2 bits (160), Expect = 1e-10
Identities = 33/82 (40%), Positives = 45/82 (54%), Gaps = 10/82 (12%)
Query: 165 SCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARS 224
+C DEFRC +GKC+ + C++ +C DGSDE +C P C +F C+ S
Sbjct: 108 TCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASC-------PVLTCGPASFQCN---S 157
Query: 225 TRCLPVERRCDGLQDCGDGSDE 246
+ C+P CD DC DGSDE
Sbjct: 158 STCIPQLWACDNDPDCEDGSDE 179
Score = 58.2 bits (139), Expect = 3e-08
Identities = 34/93 (36%), Positives = 48/93 (51%), Gaps = 13/93 (13%)
Query: 164 ASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPG-GTFPCSGA 222
A+C+ DEF+C +G C+ G QC+ +C D SDE C +LC G F C
Sbjct: 234 ATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNV------TLCEGPNKFKC--- 284
Query: 223 RSTRCLPVERRCDGLQDCGDGSDEAGCPDLACG 255
S C+ +++ C+ +DC D SDE P CG
Sbjct: 285 HSGECITLDKVCNMARDCRDWSDE---PIKECG 314
Score = 32.7 bits (73), Expect = 1.3
Identities = 18/55 (32%), Positives = 24/55 (43%), Gaps = 5/55 (9%)
Query: 202 APASEPPGSLCPGGTFPCSGARSTRCLPVERRCDGLQDCGDGSDEA--GCPDLAC 254
A A G C F C + C+ + CDG +C DGSDE+ C + C
Sbjct: 17 AAAGTAVGDRCERNEFQCQDGK---CISYKWVCDGSAECQDGSDESQETCLSVTC 68
>gi|65301164 very low density lipoprotein receptor isoform b [Homo
sapiens]
Length = 845
Score = 92.8 bits (229), Expect = 1e-18
Identities = 89/329 (27%), Positives = 124/329 (37%), Gaps = 56/329 (17%)
Query: 165 SCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARS 224
+C +F C+NG+C+P W+C+ +C DGSDE + C C GA S
Sbjct: 71 TCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDES-----PEQCHMRTCRIHEISC-GAHS 124
Query: 225 TRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARG---PSDLH 281
T+C+PV RCDG DC G DE C ++ C SPD F + G +
Sbjct: 125 TQCIPVSWRCDGENDCDSGEDEENCGNITC------------SPDEFTCSSGRCISRNFV 172
Query: 282 CTWLVDTQDSRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQG 341
C D D L G ++ Q + + S+ SLE
Sbjct: 173 CNGQDDCSDGSDELDCAPPTCGAHEF-QCSTSSCIPISWVCDDDADCSDQSDESLEQCGR 231
Query: 342 RLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQRCDGW 401
+ + A G G C+ + C D GS + C S R D
Sbjct: 232 QPVIHTKCPASEIQCG-------SGECIHKKWRCDGDPDCKDGS-DEVNCPSRTCRPD-Q 282
Query: 402 WHCASGRDEQGCPACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCFSCQ----P 457
+ C G C GS C N + C DG+DE NC + P
Sbjct: 283 FECEDG--------------SCIHGSRQC-------NGIRDCVDGSDEVNCKNVNQCLGP 321
Query: 458 GTFHCGTNLCIFETWRCDGQEDCQDGSDE 486
G F C + CI + C+ ++DC+D SDE
Sbjct: 322 GKFKCRSGECIDISKVCNQEQDCRDWSDE 350
Score = 77.4 bits (189), Expect = 5e-14
Identities = 52/194 (26%), Positives = 63/194 (32%), Gaps = 72/194 (37%)
Query: 366 GYCLPWEQPCGSSSDSDGGS--------------------LGDQGCFSEPQRCDGWWHCA 405
G C+P C D + GS C RCDG C
Sbjct: 82 GQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCD 141
Query: 406 SGRDEQGCP--ACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCF---------- 453
SG DE+ C C PD++ C SG C + CN Q C DG+DE +C
Sbjct: 142 SGEDEENCGNITCSPDEFTCS--SGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQ 199
Query: 454 --------------------------------------SCQPGTFHCGTNLCIFETWRCD 475
C CG+ CI + WRCD
Sbjct: 200 CSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCD 259
Query: 476 GQEDCQDGSDEHGC 489
G DC+DGSDE C
Sbjct: 260 GDPDCKDGSDEVNC 273
Score = 73.6 bits (179), Expect = 7e-13
Identities = 36/89 (40%), Positives = 45/89 (50%), Gaps = 5/89 (5%)
Query: 401 WWHCASGRDEQGCPA-CPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCF--SCQP 457
W SG G A C P Q+ C G C T +C+ + C DG+DEKNC +C
Sbjct: 17 WAPRESGATGTGRKAKCEPSQFQCTNGR--CITLLWKCDGDEDCVDGSDEKNCVKKTCAE 74
Query: 458 GTFHCGTNLCIFETWRCDGQEDCQDGSDE 486
F C C+ W+CDG DC+DGSDE
Sbjct: 75 SDFVCNNGQCVPSRWKCDGDPDCEDGSDE 103
Score = 72.0 bits (175), Expect = 2e-12
Identities = 36/111 (32%), Positives = 54/111 (48%), Gaps = 10/111 (9%)
Query: 142 DASSSGQAQGFRLSYIRGKLGQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCS 201
DA S Q+ R + C A E +C +G+C+ W+C+ +C DGSDE NC
Sbjct: 215 DADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCP 274
Query: 202 APASEPPGSLCPGGTFPCSGARSTRCLPVERRCDGLQDCGDGSDEAGCPDL 252
+ P C G+ C+ R+C+G++DC DGSDE C ++
Sbjct: 275 SRTCRPDQFECEDGS----------CIHGSRQCNGIRDCVDGSDEVNCKNV 315
Score = 70.5 bits (171), Expect = 6e-12
Identities = 33/86 (38%), Positives = 46/86 (53%), Gaps = 10/86 (11%)
Query: 162 GQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSG 221
G +C DEF C +G+C+ + CN D+C DGSDE +C+ P C F CS
Sbjct: 150 GNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPT-------CGAHEFQCS- 201
Query: 222 ARSTRCLPVERRCDGLQDCGDGSDEA 247
++ C+P+ CD DC D SDE+
Sbjct: 202 --TSSCIPISWVCDDDADCSDQSDES 225
Score = 69.3 bits (168), Expect = 1e-11
Identities = 36/107 (33%), Positives = 49/107 (45%), Gaps = 10/107 (9%)
Query: 391 CFSEPQRCDGWWHCASGRDEQGC--PACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGAD 448
C + +CDG C G DE+ C C + C G C +C+ C DG+D
Sbjct: 45 CITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQ--CVPSRWKCDGDPDCEDGSD 102
Query: 449 E--KNCF--SCQPGTFHCGTNL--CIFETWRCDGQEDCQDGSDEHGC 489
E + C +C+ CG + CI +WRCDG+ DC G DE C
Sbjct: 103 ESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENC 149
Score = 67.4 bits (163), Expect = 5e-11
Identities = 33/76 (43%), Positives = 40/76 (52%), Gaps = 4/76 (5%)
Query: 416 CPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCFS--CQPGTFHCGTNLCIFETWR 473
CP + C GSG C RC+ C DG+DE NC S C+P F C CI + +
Sbjct: 239 CPASEIQC--GSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQ 296
Query: 474 CDGQEDCQDGSDEHGC 489
C+G DC DGSDE C
Sbjct: 297 CNGIRDCVDGSDEVNC 312
Score = 52.4 bits (124), Expect = 2e-06
Identities = 25/62 (40%), Positives = 31/62 (50%), Gaps = 8/62 (12%)
Query: 429 LCYTPADRCNNQKSCPDGADEKNCFSCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHG 488
LC+ P ++S G K C+P F C CI W+CDG EDC DGSDE
Sbjct: 15 LCWAP------RESGATGTGRKA--KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKN 66
Query: 489 CL 490
C+
Sbjct: 67 CV 68
Score = 38.5 bits (88), Expect = 0.024
Identities = 17/43 (39%), Positives = 22/43 (51%), Gaps = 3/43 (6%)
Query: 212 CPGGTFPCSGARSTRCLPVERRCDGLQDCGDGSDEAGCPDLAC 254
C F C+ R C+ + +CDG +DC DGSDE C C
Sbjct: 33 CEPSQFQCTNGR---CITLLWKCDGDEDCVDGSDEKNCVKKTC 72
>gi|65301167 very low density lipoprotein receptor isoform a [Homo
sapiens]
Length = 873
Score = 92.8 bits (229), Expect = 1e-18
Identities = 89/329 (27%), Positives = 124/329 (37%), Gaps = 56/329 (17%)
Query: 165 SCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARS 224
+C +F C+NG+C+P W+C+ +C DGSDE + C C GA S
Sbjct: 71 TCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDES-----PEQCHMRTCRIHEISC-GAHS 124
Query: 225 TRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARG---PSDLH 281
T+C+PV RCDG DC G DE C ++ C SPD F + G +
Sbjct: 125 TQCIPVSWRCDGENDCDSGEDEENCGNITC------------SPDEFTCSSGRCISRNFV 172
Query: 282 CTWLVDTQDSRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQG 341
C D D L G ++ Q + + S+ SLE
Sbjct: 173 CNGQDDCSDGSDELDCAPPTCGAHEF-QCSTSSCIPISWVCDDDADCSDQSDESLEQCGR 231
Query: 342 RLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQRCDGW 401
+ + A G G C+ + C D GS + C S R D
Sbjct: 232 QPVIHTKCPASEIQCG-------SGECIHKKWRCDGDPDCKDGS-DEVNCPSRTCRPD-Q 282
Query: 402 WHCASGRDEQGCPACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCFSCQ----P 457
+ C G C GS C N + C DG+DE NC + P
Sbjct: 283 FECEDG--------------SCIHGSRQC-------NGIRDCVDGSDEVNCKNVNQCLGP 321
Query: 458 GTFHCGTNLCIFETWRCDGQEDCQDGSDE 486
G F C + CI + C+ ++DC+D SDE
Sbjct: 322 GKFKCRSGECIDISKVCNQEQDCRDWSDE 350
Score = 77.4 bits (189), Expect = 5e-14
Identities = 52/194 (26%), Positives = 63/194 (32%), Gaps = 72/194 (37%)
Query: 366 GYCLPWEQPCGSSSDSDGGS--------------------LGDQGCFSEPQRCDGWWHCA 405
G C+P C D + GS C RCDG C
Sbjct: 82 GQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCD 141
Query: 406 SGRDEQGCP--ACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCF---------- 453
SG DE+ C C PD++ C SG C + CN Q C DG+DE +C
Sbjct: 142 SGEDEENCGNITCSPDEFTCS--SGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQ 199
Query: 454 --------------------------------------SCQPGTFHCGTNLCIFETWRCD 475
C CG+ CI + WRCD
Sbjct: 200 CSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCD 259
Query: 476 GQEDCQDGSDEHGC 489
G DC+DGSDE C
Sbjct: 260 GDPDCKDGSDEVNC 273
Score = 73.6 bits (179), Expect = 7e-13
Identities = 36/89 (40%), Positives = 45/89 (50%), Gaps = 5/89 (5%)
Query: 401 WWHCASGRDEQGCPA-CPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCF--SCQP 457
W SG G A C P Q+ C G C T +C+ + C DG+DEKNC +C
Sbjct: 17 WAPRESGATGTGRKAKCEPSQFQCTNGR--CITLLWKCDGDEDCVDGSDEKNCVKKTCAE 74
Query: 458 GTFHCGTNLCIFETWRCDGQEDCQDGSDE 486
F C C+ W+CDG DC+DGSDE
Sbjct: 75 SDFVCNNGQCVPSRWKCDGDPDCEDGSDE 103
Score = 72.0 bits (175), Expect = 2e-12
Identities = 36/111 (32%), Positives = 54/111 (48%), Gaps = 10/111 (9%)
Query: 142 DASSSGQAQGFRLSYIRGKLGQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCS 201
DA S Q+ R + C A E +C +G+C+ W+C+ +C DGSDE NC
Sbjct: 215 DADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCP 274
Query: 202 APASEPPGSLCPGGTFPCSGARSTRCLPVERRCDGLQDCGDGSDEAGCPDL 252
+ P C G+ C+ R+C+G++DC DGSDE C ++
Sbjct: 275 SRTCRPDQFECEDGS----------CIHGSRQCNGIRDCVDGSDEVNCKNV 315
Score = 70.5 bits (171), Expect = 6e-12
Identities = 33/86 (38%), Positives = 46/86 (53%), Gaps = 10/86 (11%)
Query: 162 GQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSG 221
G +C DEF C +G+C+ + CN D+C DGSDE +C+ P C F CS
Sbjct: 150 GNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPT-------CGAHEFQCS- 201
Query: 222 ARSTRCLPVERRCDGLQDCGDGSDEA 247
++ C+P+ CD DC D SDE+
Sbjct: 202 --TSSCIPISWVCDDDADCSDQSDES 225
Score = 69.3 bits (168), Expect = 1e-11
Identities = 36/107 (33%), Positives = 49/107 (45%), Gaps = 10/107 (9%)
Query: 391 CFSEPQRCDGWWHCASGRDEQGC--PACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGAD 448
C + +CDG C G DE+ C C + C G C +C+ C DG+D
Sbjct: 45 CITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQ--CVPSRWKCDGDPDCEDGSD 102
Query: 449 E--KNCF--SCQPGTFHCGTNL--CIFETWRCDGQEDCQDGSDEHGC 489
E + C +C+ CG + CI +WRCDG+ DC G DE C
Sbjct: 103 ESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENC 149
Score = 67.4 bits (163), Expect = 5e-11
Identities = 33/76 (43%), Positives = 40/76 (52%), Gaps = 4/76 (5%)
Query: 416 CPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCFS--CQPGTFHCGTNLCIFETWR 473
CP + C GSG C RC+ C DG+DE NC S C+P F C CI + +
Sbjct: 239 CPASEIQC--GSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQ 296
Query: 474 CDGQEDCQDGSDEHGC 489
C+G DC DGSDE C
Sbjct: 297 CNGIRDCVDGSDEVNC 312
Score = 52.4 bits (124), Expect = 2e-06
Identities = 25/62 (40%), Positives = 31/62 (50%), Gaps = 8/62 (12%)
Query: 429 LCYTPADRCNNQKSCPDGADEKNCFSCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHG 488
LC+ P ++S G K C+P F C CI W+CDG EDC DGSDE
Sbjct: 15 LCWAP------RESGATGTGRKA--KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKN 66
Query: 489 CL 490
C+
Sbjct: 67 CV 68
Score = 38.5 bits (88), Expect = 0.024
Identities = 17/43 (39%), Positives = 22/43 (51%), Gaps = 3/43 (6%)
Query: 212 CPGGTFPCSGARSTRCLPVERRCDGLQDCGDGSDEAGCPDLAC 254
C F C+ R C+ + +CDG +DC DGSDE C C
Sbjct: 33 CEPSQFQCTNGR---CITLLWKCDGDEDCVDGSDEKNCVKKTC 72
>gi|28557796 low density lipoprotein receptor class A domain
containing 3 [Homo sapiens]
Length = 345
Score = 90.9 bits (224), Expect = 4e-18
Identities = 54/150 (36%), Positives = 71/150 (47%), Gaps = 25/150 (16%)
Query: 391 CFSEPQRCDGWWHCASGRDEQGCPA----CPPDQYPCEGGSGLCYTPADRCNNQKSCPDG 446
C +CDG C DE+ CP C P +PC G C RCN + CPDG
Sbjct: 42 CIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIH-CIIGRFRCNGFEDCPDG 100
Query: 447 ADEKNCFS----CQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCLAA---------- 492
+DE+NC + C +HC LCI +++ CDGQ +CQD SDE C ++
Sbjct: 101 SDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQEPGSGQVFV 160
Query: 493 ------VPRKVITAALIGSLVCGLLLVIAL 516
V IT A+IGS V +L+V L
Sbjct: 161 TSENQLVYYPSITYAIIGSSVIFVLVVALL 190
Score = 73.6 bits (179), Expect = 7e-13
Identities = 34/79 (43%), Positives = 43/79 (54%), Gaps = 7/79 (8%)
Query: 171 FRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARSTRCLPV 230
F C NG+C+PG WQC+ + +C D SDE C S+ C FPC A C+
Sbjct: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSK-----CGPTFFPC--ASGIHCIIG 87
Query: 231 ERRCDGLQDCGDGSDEAGC 249
RC+G +DC DGSDE C
Sbjct: 88 RFRCNGFEDCPDGSDEENC 106
Score = 58.5 bits (140), Expect = 2e-08
Identities = 31/79 (39%), Positives = 39/79 (49%), Gaps = 7/79 (8%)
Query: 418 PDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNC----FSCQPGTFHCGTNL-CIFETW 472
P + C G C A +C+ C D +DEK C C P F C + + CI +
Sbjct: 32 PGNFMCSNGR--CIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRF 89
Query: 473 RCDGQEDCQDGSDEHGCLA 491
RC+G EDC DGSDE C A
Sbjct: 90 RCNGFEDCPDGSDEENCTA 108
Score = 55.5 bits (132), Expect = 2e-07
Identities = 30/88 (34%), Positives = 44/88 (50%), Gaps = 9/88 (10%)
Query: 163 QASCQADEFRCDNG-KCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSG 221
++ C F C +G C+ G ++CN ++C DGSDE NC+A LC + C
Sbjct: 68 KSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANP-----LLCSTARYHC-- 120
Query: 222 ARSTRCLPVERRCDGLQDCGDGSDEAGC 249
++ C+ CDG +C D SDE C
Sbjct: 121 -KNGLCIDKSFICDGQNNCQDNSDEESC 147
Score = 41.2 bits (95), Expect = 0.004
Identities = 26/68 (38%), Positives = 29/68 (42%), Gaps = 16/68 (23%)
Query: 215 GTFPCSGARSTRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAA 274
G F CS R C+P +CDGL DC D SDE CP S P F A
Sbjct: 33 GNFMCSNGR---CIPGAWQCDGLPDCFDKSDEKECPKAK----------SKCGPTFFPCA 79
Query: 275 RGPSDLHC 282
G +HC
Sbjct: 80 SG---IHC 84
Score = 37.7 bits (86), Expect = 0.041
Identities = 16/45 (35%), Positives = 24/45 (53%), Gaps = 2/45 (4%)
Query: 166 CQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGS 210
C + C NG C+ + C+ + C D SDE +C +S+ PGS
Sbjct: 113 CSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCE--SSQEPGS 155
>gi|61744471 low density lipoprotein receptor-related protein 8
isoform 1 precursor [Homo sapiens]
Length = 963
Score = 90.5 bits (223), Expect = 5e-18
Identities = 89/334 (26%), Positives = 125/334 (37%), Gaps = 55/334 (16%)
Query: 166 CQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARST 225
C+ D+F+C N +C+P W+C+ D+C D SDE +C P C F C
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC-------PKKTCADSDFTCDNG--- 96
Query: 226 RCLPVERRCDGLQDCGDGSD--EAGCPDLACGRRLGSFYGSFASPDLFGAARGPSDLHCT 283
C+ +CDG ++C DGSD EA C C S G + + + R + C
Sbjct: 97 HCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLS-CGPTSHKCVPASWRCDGEKDCE 155
Query: 284 WLVDTQDSRRVLLQLELRLGYDD---YVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQ 340
D + E + G V V +G + GD S+ R + A
Sbjct: 156 GGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGD--------GSDERGCADPACG 207
Query: 341 GRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLG--DQGCFSEPQRC 398
R R G G A + C + C SD G G S P C
Sbjct: 208 PR-------EFRCGGDGGGACIPERWVC-DRQFDCEDRSDEAAELCGRPGPGATSAPAAC 259
Query: 399 --DGWWHCASGRDEQGCPACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCFSCQ 456
+ C SG C + C+G C +D + CP G +C+
Sbjct: 260 ATASQFACRSGE-------CVHLGWRCDGDRD-CKDKSD----EADCPLG-------TCR 300
Query: 457 PGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCL 490
F CG C+ C+ ++DC DGSDE GCL
Sbjct: 301 GDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCL 334
Score = 80.1 bits (196), Expect = 7e-15
Identities = 54/167 (32%), Positives = 70/167 (41%), Gaps = 27/167 (16%)
Query: 355 GHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQ--------------RCDG 400
GH + ++ G E+ C SD + Q C +E RCDG
Sbjct: 96 GHCIHERWKCDG-----EEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDG 150
Query: 401 WWHCASGRDEQGCPA-CPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCF--SCQP 457
C G DE GC C P ++ C G+ C C+ C DG+DE+ C +C P
Sbjct: 151 EKDCEGGADEAGCATLCAPHEFQC--GNRSCLAAVFVCDGDDDCGDGSDERGCADPACGP 208
Query: 458 GTFHCGTN---LCIFETWRCDGQEDCQDGSDEHGCLAAVPRKVITAA 501
F CG + CI E W CD Q DC+D SDE L P T+A
Sbjct: 209 REFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSA 255
Score = 76.6 bits (187), Expect = 8e-14
Identities = 44/125 (35%), Positives = 57/125 (45%), Gaps = 32/125 (25%)
Query: 165 SCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSA-----PASE----PPGSLCPGG 215
+C +F CDNG C+ W+C+ +EC DGSDE + PA + P C
Sbjct: 85 TCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPA 144
Query: 216 TFPCSGAR-----------STRCLPVERRC------------DGLQDCGDGSDEAGCPDL 252
++ C G + +T C P E +C DG DCGDGSDE GC D
Sbjct: 145 SWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADP 204
Query: 253 ACGRR 257
ACG R
Sbjct: 205 ACGPR 209
Score = 64.7 bits (156), Expect = 3e-10
Identities = 38/98 (38%), Positives = 47/98 (47%), Gaps = 11/98 (11%)
Query: 165 SCQADEFRCDN---GKCLPGPWQCNTVDECGDGSDEGN--CSAP---ASEPPGSLCPGGT 216
+C EFRC G C+P W C+ +C D SDE C P A+ P +
Sbjct: 205 ACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQ 264
Query: 217 FPCSGARSTRCLPVERRCDGLQDCGDGSDEAGCPDLAC 254
F C RS C+ + RCDG +DC D SDEA CP C
Sbjct: 265 FAC---RSGECVHLGWRCDGDRDCKDKSDEADCPLGTC 299
Score = 62.8 bits (151), Expect = 1e-09
Identities = 32/86 (37%), Positives = 43/86 (50%), Gaps = 10/86 (11%)
Query: 164 ASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGAR 223
A A +F C +G+C+ W+C+ +C D SDE +C P C G F C
Sbjct: 258 ACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADC-------PLGTCRGDEFQCGDG- 309
Query: 224 STRCLPVERRCDGLQDCGDGSDEAGC 249
C+ + C+ QDC DGSDEAGC
Sbjct: 310 --TCVLAIKHCNQEQDCPDGSDEAGC 333
Score = 46.6 bits (109), Expect = 9e-05
Identities = 35/107 (32%), Positives = 47/107 (43%), Gaps = 13/107 (12%)
Query: 165 SCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARS 224
+C+ DEF+C +G C+ CN +C DGSDE C +E C CS +
Sbjct: 298 TCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNE-----CLHNNGGCSHICT 352
Query: 225 TRCLPVERRCD-GLQ-----DCGDGSDEAGCPDLACGRRLGSFYGSF 265
+ E C G Q CGD DE PD AC + ++ G F
Sbjct: 353 DLKIGFECTCPAGFQLLDQKTCGD-IDECKDPD-ACSQICVNYKGYF 397
>gi|65301119 low density lipoprotein receptor-related protein 8
isoform 4 precursor [Homo sapiens]
Length = 904
Score = 90.5 bits (223), Expect = 5e-18
Identities = 89/334 (26%), Positives = 125/334 (37%), Gaps = 55/334 (16%)
Query: 166 CQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARST 225
C+ D+F+C N +C+P W+C+ D+C D SDE +C P C F C
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC-------PKKTCADSDFTCDNG--- 96
Query: 226 RCLPVERRCDGLQDCGDGSD--EAGCPDLACGRRLGSFYGSFASPDLFGAARGPSDLHCT 283
C+ +CDG ++C DGSD EA C C S G + + + R + C
Sbjct: 97 HCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLS-CGPTSHKCVPASWRCDGEKDCE 155
Query: 284 WLVDTQDSRRVLLQLELRLGYDD---YVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQ 340
D + E + G V V +G + GD S+ R + A
Sbjct: 156 GGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGD--------GSDERGCADPACG 207
Query: 341 GRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLG--DQGCFSEPQRC 398
R R G G A + C + C SD G G S P C
Sbjct: 208 PR-------EFRCGGDGGGACIPERWVC-DRQFDCEDRSDEAAELCGRPGPGATSAPAAC 259
Query: 399 --DGWWHCASGRDEQGCPACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCFSCQ 456
+ C SG C + C+G C +D + CP G +C+
Sbjct: 260 ATASQFACRSGE-------CVHLGWRCDGDRD-CKDKSD----EADCPLG-------TCR 300
Query: 457 PGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCL 490
F CG C+ C+ ++DC DGSDE GCL
Sbjct: 301 GDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCL 334
Score = 80.1 bits (196), Expect = 7e-15
Identities = 54/167 (32%), Positives = 70/167 (41%), Gaps = 27/167 (16%)
Query: 355 GHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQ--------------RCDG 400
GH + ++ G E+ C SD + Q C +E RCDG
Sbjct: 96 GHCIHERWKCDG-----EEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDG 150
Query: 401 WWHCASGRDEQGCPA-CPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCF--SCQP 457
C G DE GC C P ++ C G+ C C+ C DG+DE+ C +C P
Sbjct: 151 EKDCEGGADEAGCATLCAPHEFQC--GNRSCLAAVFVCDGDDDCGDGSDERGCADPACGP 208
Query: 458 GTFHCGTN---LCIFETWRCDGQEDCQDGSDEHGCLAAVPRKVITAA 501
F CG + CI E W CD Q DC+D SDE L P T+A
Sbjct: 209 REFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSA 255
Score = 76.6 bits (187), Expect = 8e-14
Identities = 44/125 (35%), Positives = 57/125 (45%), Gaps = 32/125 (25%)
Query: 165 SCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSA-----PASE----PPGSLCPGG 215
+C +F CDNG C+ W+C+ +EC DGSDE + PA + P C
Sbjct: 85 TCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPA 144
Query: 216 TFPCSGAR-----------STRCLPVERRC------------DGLQDCGDGSDEAGCPDL 252
++ C G + +T C P E +C DG DCGDGSDE GC D
Sbjct: 145 SWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADP 204
Query: 253 ACGRR 257
ACG R
Sbjct: 205 ACGPR 209
Score = 64.7 bits (156), Expect = 3e-10
Identities = 38/98 (38%), Positives = 47/98 (47%), Gaps = 11/98 (11%)
Query: 165 SCQADEFRCDN---GKCLPGPWQCNTVDECGDGSDEGN--CSAP---ASEPPGSLCPGGT 216
+C EFRC G C+P W C+ +C D SDE C P A+ P +
Sbjct: 205 ACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQ 264
Query: 217 FPCSGARSTRCLPVERRCDGLQDCGDGSDEAGCPDLAC 254
F C RS C+ + RCDG +DC D SDEA CP C
Sbjct: 265 FAC---RSGECVHLGWRCDGDRDCKDKSDEADCPLGTC 299
Score = 62.8 bits (151), Expect = 1e-09
Identities = 32/86 (37%), Positives = 43/86 (50%), Gaps = 10/86 (11%)
Query: 164 ASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGAR 223
A A +F C +G+C+ W+C+ +C D SDE +C P C G F C
Sbjct: 258 ACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADC-------PLGTCRGDEFQCGDG- 309
Query: 224 STRCLPVERRCDGLQDCGDGSDEAGC 249
C+ + C+ QDC DGSDEAGC
Sbjct: 310 --TCVLAIKHCNQEQDCPDGSDEAGC 333
Score = 46.6 bits (109), Expect = 9e-05
Identities = 35/107 (32%), Positives = 47/107 (43%), Gaps = 13/107 (12%)
Query: 165 SCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARS 224
+C+ DEF+C +G C+ CN +C DGSDE C +E C CS +
Sbjct: 298 TCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNE-----CLHNNGGCSHICT 352
Query: 225 TRCLPVERRCD-GLQ-----DCGDGSDEAGCPDLACGRRLGSFYGSF 265
+ E C G Q CGD DE PD AC + ++ G F
Sbjct: 353 DLKIGFECTCPAGFQLLDQKTCGD-IDECKDPD-ACSQICVNYKGYF 397
>gi|29244926 corin [Homo sapiens]
Length = 1042
Score = 89.7 bits (221), Expect = 9e-18
Identities = 88/358 (24%), Positives = 129/358 (36%), Gaps = 43/358 (12%)
Query: 165 SCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSA-PASEP--PGSLCPGGTFPCSG 221
+C + F C GKCL C+ D+CGD SDE NC P +E C + C G
Sbjct: 305 NCSENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNCDCNPTTEHRCGDGRCIAMEWVCDG 364
Query: 222 ----------------------ARSTRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLG 259
R+ +C+P +CDG +DC DGSDE C + + G
Sbjct: 365 DHDCVDKSDEVNCSCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEG 424
Query: 260 SFYGSFASPDLFGAARGPSDLHCTWLVDTQDSRRVLLQLELRLGYDDYVQVYEGLGERGD 319
+P L L + + L+L + L Y+ Y
Sbjct: 425 D-QRCLYNPCLDSCGGSSLCDPNNSLNNCSQCEPITLELCMNLPYNS--TSYPNYFGHRT 481
Query: 320 RLLQTLSYRSNHRPVSLEAAQGRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSS 379
+ ++S+ S+ P ++ + + + N + P C S
Sbjct: 482 QKEASISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIP----PCRALCEHSK 537
Query: 380 DSDGGSLGDQGCFSEPQRCDGWWHCASGRDEQGC-------PACPPDQYPCEGGSGLCYT 432
+ LG G P+ D D Q C C P + C SG C
Sbjct: 538 ERCESVLGIVG-LQWPEDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCR--SGQCVL 594
Query: 433 PADRCNNQKSCPDGADEKNCFSCQPGTFHCGTN-LCIFETWRCDGQEDCQDGSDEHGC 489
+ RC+ Q C D +DE+NC + + C +N C+ T CDG DC D DE C
Sbjct: 595 ASRRCDGQADCDDDSDEENCGCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNC 652
Score = 83.6 bits (205), Expect = 6e-16
Identities = 46/139 (33%), Positives = 59/139 (42%), Gaps = 19/139 (13%)
Query: 366 GYCLPWEQPCGSSSDSDGGSLGDQG---------------CFSEPQRCDGWWHCASGRDE 410
G C+P + C +D D S D+ C + CDG+ C DE
Sbjct: 280 GICIPGKLQCNGYNDCDDWS--DEAHCNCSENLFHCHTGKCLNYSLVCDGYDDCGDLSDE 337
Query: 411 QGCPACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCFSCQPGTFHCGTNLCIFE 470
Q C P ++ C G G C C+ C D +DE NC G C CI
Sbjct: 338 QNCDCNPTTEHRC--GDGRCIAMEWVCDGDHDCVDKSDEVNCSCHSQGLVECRNGQCIPS 395
Query: 471 TWRCDGQEDCQDGSDEHGC 489
T++CDG EDC+DGSDE C
Sbjct: 396 TFQCDGDEDCKDGSDEENC 414
Score = 74.7 bits (182), Expect = 3e-13
Identities = 35/100 (35%), Positives = 43/100 (43%), Gaps = 1/100 (1%)
Query: 391 CFSEPQRCDGWWHCASGRDEQGCPACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEK 450
C +RCDG C DE+ C D + C C C+ CPD DEK
Sbjct: 592 CVLASRRCDGQADCDDDSDEENCGCKERDLWECPSNKQ-CLKHTVICDGFPDCPDYMDEK 650
Query: 451 NCFSCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCL 490
NC CQ C + C+ CDG+ DC D SDE C+
Sbjct: 651 NCSFCQDDELECANHACVSRDLWCDGEADCSDSSDEWDCV 690
Score = 63.2 bits (152), Expect = 9e-10
Identities = 31/83 (37%), Positives = 41/83 (49%), Gaps = 13/83 (15%)
Query: 167 QADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARSTR 226
+ + F C +G C+PG QCN ++C D SDE +C+ C F C + +
Sbjct: 271 RGENFLCASGICIPGKLQCNGYNDCDDWSDEAHCN----------CSENLFHC---HTGK 317
Query: 227 CLPVERRCDGLQDCGDGSDEAGC 249
CL CDG DCGD SDE C
Sbjct: 318 CLNYSLVCDGYDDCGDLSDEQNC 340
Score = 50.4 bits (119), Expect = 6e-06
Identities = 32/122 (26%), Positives = 44/122 (36%), Gaps = 26/122 (21%)
Query: 166 CQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASE----PPGSLCPGGTFPCSG 221
C F+C +G+C+ +C+ +C D SDE NC + P C T C G
Sbjct: 580 CSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCKERDLWECPSNKQCLKHTVICDG 639
Query: 222 ----------------------ARSTRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLG 259
+ C+ + CDG DC D SDE C L+
Sbjct: 640 FPDCPDYMDEKNCSFCQDDELECANHACVSRDLWCDGEADCSDSSDEWDCVTLSINVNSS 699
Query: 260 SF 261
SF
Sbjct: 700 SF 701
Score = 43.9 bits (102), Expect = 6e-04
Identities = 30/92 (32%), Positives = 40/92 (43%), Gaps = 12/92 (13%)
Query: 163 QASCQADEFRCDN-----GKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTF 217
+A C+ + RC++ G P C+ E + SD C P + C F
Sbjct: 530 RALCEHSKERCESVLGIVGLQWPEDTDCSQFPE--ENSDNQTCLMP--DEYVEECSPSHF 585
Query: 218 PCSGARSTRCLPVERRCDGLQDCGDGSDEAGC 249
C RS +C+ RRCDG DC D SDE C
Sbjct: 586 KC---RSGQCVLASRRCDGQADCDDDSDEENC 614
Score = 41.6 bits (96), Expect = 0.003
Identities = 21/81 (25%), Positives = 33/81 (40%), Gaps = 2/81 (2%)
Query: 372 EQPCGSSSDSDGGSLGDQGCFSEPQRCDGWWHCASGRDEQGCPACPPDQYPCEGGSGLCY 431
E+ CG ++ C CDG+ C DE+ C C D+ C + C
Sbjct: 611 EENCGCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCSFCQDDELEC--ANHACV 668
Query: 432 TPADRCNNQKSCPDGADEKNC 452
+ C+ + C D +DE +C
Sbjct: 669 SRDLWCDGEADCSDSSDEWDC 689
Score = 37.0 bits (84), Expect = 0.069
Identities = 19/63 (30%), Positives = 27/63 (42%), Gaps = 11/63 (17%)
Query: 427 SGLCYTPADRCNNQKSCPDGADEKNCFSCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDE 486
S +C++P Q C G + F C + +CI +C+G DC D SDE
Sbjct: 253 SRICFSPQQENGKQLLCGRGEN-----------FLCASGICIPGKLQCNGYNDCDDWSDE 301
Query: 487 HGC 489
C
Sbjct: 302 AHC 304
>gi|119709832 low density lipoprotein receptor-related protein 5 [Homo
sapiens]
Length = 1615
Score = 87.8 bits (216), Expect = 3e-17
Identities = 44/123 (35%), Positives = 58/123 (47%), Gaps = 3/123 (2%)
Query: 373 QPCGSSSDSDGGSLGDQGCFSEPQRCDGWWHCASGRDEQGCPACPPDQYPCEGGSGLCYT 432
+P S D + G+ C RCDG+ C DE+GCP C Q+PC G C
Sbjct: 1255 EPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPC--ARGQCVD 1312
Query: 433 PADRCNNQKSCPDGADEKNCFS-CQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCLA 491
RC+ + C D +DE +C + C P F C + C+ +CD DC DGSDE C
Sbjct: 1313 LRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEI 1372
Query: 492 AVP 494
P
Sbjct: 1373 TKP 1375
Score = 71.2 bits (173), Expect = 3e-12
Identities = 36/92 (39%), Positives = 47/92 (51%), Gaps = 15/92 (16%)
Query: 165 SCQADEFRCDNGK--CLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGA 222
+C D+F C G+ C+PG W+C+ EC D SDE C +C FPC+
Sbjct: 1258 TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGC---------PVCSAAQFPCARG 1308
Query: 223 RSTRCLPVERRCDGLQDCGDGSDEAGCPDLAC 254
+C+ + RCDG DC D SDEA C D C
Sbjct: 1309 ---QCVDLRLRCDGEADCQDRSDEADC-DAIC 1336
Score = 41.6 bits (96), Expect = 0.003
Identities = 24/68 (35%), Positives = 29/68 (42%), Gaps = 12/68 (17%)
Query: 192 GDGSDEGNCSA---------PASEPPGSLCPGGTFPCSGARSTRCLPVERRCDGLQDCGD 242
GDG+ +C EPP C F C+ C+P RCDG +C D
Sbjct: 1232 GDGTPRCSCPVHLVLLQNLLTCGEPP--TCSPDQFACATGEID-CIPGAWRCDGFPECDD 1288
Query: 243 GSDEAGCP 250
SDE GCP
Sbjct: 1289 QSDEEGCP 1296
Score = 40.0 bits (92), Expect = 0.008
Identities = 19/50 (38%), Positives = 29/50 (58%), Gaps = 2/50 (4%)
Query: 164 ASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCP 213
A C ++FRC +G+C+ QC++ +C DGSDE C ++PP P
Sbjct: 1334 AICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCE--ITKPPSDDSP 1381
>gi|148727288 low density lipoprotein receptor-related protein 6 [Homo
sapiens]
Length = 1613
Score = 86.7 bits (213), Expect = 8e-17
Identities = 45/135 (33%), Positives = 59/135 (43%), Gaps = 3/135 (2%)
Query: 387 GDQGCFSEPQRCDGWWHCASGRDEQGCPACPPDQYPCEGGSGLCYTPADRCNNQKSCPDG 446
G+ C RCDG+ C DE CP C Q+ C SG C A RCN +C D
Sbjct: 1259 GEIDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQC--ASGQCIDGALRCNGDANCQDK 1316
Query: 447 ADEKNC-FSCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCLAAVPRKVITAALIGS 505
+DEKNC C F C CI + +CD DC D SDE C +GS
Sbjct: 1317 SDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEPAPQATNTVGS 1376
Query: 506 LVCGLLLVIALGCAF 520
++ ++ + G +
Sbjct: 1377 VIGVIVTIFVSGTVY 1391
Score = 73.6 bits (179), Expect = 7e-13
Identities = 37/96 (38%), Positives = 44/96 (45%), Gaps = 3/96 (3%)
Query: 397 RCDGWWHCASGRDEQGC---PACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCF 453
RC H +DE C P C P Q+ C G C A RC+ C D +DE NC
Sbjct: 1227 RCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP 1286
Query: 454 SCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGC 489
C F C + CI RC+G +CQD SDE C
Sbjct: 1287 VCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC 1322
Score = 58.2 bits (139), Expect = 3e-08
Identities = 29/84 (34%), Positives = 40/84 (47%), Gaps = 11/84 (13%)
Query: 166 CQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARST 225
C +F+C +G+C+ G +CN C D SDE NC LC F C+
Sbjct: 1288 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEV--------LCLIDQFRCANG--- 1336
Query: 226 RCLPVERRCDGLQDCGDGSDEAGC 249
+C+ ++CD DC D SDE C
Sbjct: 1337 QCIGKHKKCDHNVDCSDKSDELDC 1360
Score = 56.2 bits (134), Expect = 1e-07
Identities = 30/87 (34%), Positives = 42/87 (48%), Gaps = 14/87 (16%)
Query: 165 SCQADEFRCDNGK--CLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGA 222
+C +F C G+ C+P W+C+ EC D SDE NC +C F C+
Sbjct: 1248 TCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNC---------PVCSESQFQCA-- 1296
Query: 223 RSTRCLPVERRCDGLQDCGDGSDEAGC 249
S +C+ RC+G +C D SDE C
Sbjct: 1297 -SGQCIDGALRCNGDANCQDKSDEKNC 1322
Score = 40.4 bits (93), Expect = 0.006
Identities = 31/100 (31%), Positives = 39/100 (39%), Gaps = 17/100 (17%)
Query: 192 GDGSDEGNC---------SAPASEPPGSLCPGGTFPCSGARSTRCLPVERRCDGLQDCGD 242
GDG+ +C EPP C F C C+PV RCDG +C D
Sbjct: 1222 GDGTTRCSCPMHLVLLQDELSCGEPP--TCSPQQFTCFTGEID-CIPVAWRCDGFTECED 1278
Query: 243 GSDEAGCPDLACGRRLGSFYGSFASPDLFGAARGPSDLHC 282
SDE CP C S + + + GA R D +C
Sbjct: 1279 HSDELNCP--VCSE---SQFQCASGQCIDGALRCNGDANC 1313
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 85.5 bits (210), Expect = 2e-16
Identities = 49/136 (36%), Positives = 64/136 (47%), Gaps = 19/136 (13%)
Query: 374 PCGSSSDSDGGSLGDQGCFSEPQRCDGWWHCASGRDEQGC---PACPPDQYPCEGGSGLC 430
PCG + + C CDG C G DE C P C P+++PC G+G C
Sbjct: 284 PCGPQE----AACRNGHCIPRDYLCDGQEDCEDGSDELDCGPPPPCEPNEFPC--GNGHC 337
Query: 431 YTPADRCNNQKSCPDGADEKNCFS------CQPGTFHC-GTNLCIFETWRCDGQEDCQDG 483
RC+ C D DE NC + C P F C TN+CI ++ CD + DC D
Sbjct: 338 ALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCVSTNMCIPASFHCDEESDCPDR 397
Query: 484 SDEHGCLAAVPRKVIT 499
SDE GC+ P +V+T
Sbjct: 398 SDEFGCM---PPQVVT 410
Score = 67.4 bits (163), Expect = 5e-11
Identities = 36/92 (39%), Positives = 44/92 (47%), Gaps = 9/92 (9%)
Query: 159 GKLGQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFP 218
G + C E C NG C+P + C+ ++C DGSDE +C P PP C FP
Sbjct: 278 GSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELDCGPP---PP---CEPNEFP 331
Query: 219 CSGARSTRCLPVERRCDGLQDCGDGSDEAGCP 250
C C RCDG DC D +DEA CP
Sbjct: 332 CGNG---HCALKLWRCDGDFDCEDRTDEANCP 360
Score = 64.3 bits (155), Expect = 4e-10
Identities = 31/84 (36%), Positives = 42/84 (50%), Gaps = 5/84 (5%)
Query: 166 CQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARST 225
C+ +EF C NG C W+C+ +C D +DE NC ++ P +C F C +
Sbjct: 325 CEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANC---PTKRPEEVCGPTQFRC--VSTN 379
Query: 226 RCLPVERRCDGLQDCGDGSDEAGC 249
C+P CD DC D SDE GC
Sbjct: 380 MCIPASFHCDEESDCPDRSDEFGC 403
Score = 55.8 bits (133), Expect = 1e-07
Identities = 44/177 (24%), Positives = 62/177 (35%), Gaps = 63/177 (35%)
Query: 136 WIFFHSDASSSGQAQGFRL--------------SYIRGKLG------------QASCQAD 169
W+F D S G A G ++ SY+ G +C
Sbjct: 143 WVFVELDVGSEGNADGAQIQEMLLRVISSGSVASYVTSPQGFQFRRLGTVPQFPRACTEA 202
Query: 170 EFRCDN-GKCLPGPWQCNTVDECGDGSDEGNC---------------------------- 200
EF C + +C+ ++C+ +C D SDE NC
Sbjct: 203 EFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPRPETTI 262
Query: 201 --SAPASEPPGSLCPGGT--FPC----SGARSTRCLPVERRCDGLQDCGDGSDEAGC 249
P + P L PG PC + R+ C+P + CDG +DC DGSDE C
Sbjct: 263 MRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELDC 319
Score = 35.0 bits (79), Expect = 0.26
Identities = 15/44 (34%), Positives = 20/44 (45%), Gaps = 1/44 (2%)
Query: 166 CQADEFRC-DNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPP 208
C +FRC C+P + C+ +C D SDE C P P
Sbjct: 368 CGPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGCMPPQVVTP 411
Score = 33.9 bits (76), Expect = 0.59
Identities = 15/37 (40%), Positives = 21/37 (56%), Gaps = 1/37 (2%)
Query: 454 SCQPGTFHCGT-NLCIFETWRCDGQEDCQDGSDEHGC 489
+C F C + N C+ +RCD + DC+D SDE C
Sbjct: 198 ACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNC 234
Score = 32.7 bits (73), Expect = 1.3
Identities = 16/44 (36%), Positives = 19/44 (43%), Gaps = 2/44 (4%)
Query: 212 CPGGTFPCSGARSTRCLPVERRCDGLQDCGDGSDEAGCPDLACG 255
C F C C+ +E RCD DC D SDE C + G
Sbjct: 199 CTEAEFACHSYNE--CVALEYRCDRRPDCRDMSDELNCEEPVLG 240
Score = 32.3 bits (72), Expect = 1.7
Identities = 20/69 (28%), Positives = 32/69 (46%), Gaps = 2/69 (2%)
Query: 689 RDPECRPVDKDRKVCREPLVDGPAPADAPREPCSAQDPHPQVSTASSTLGPHSPEPLGVC 748
R P+CR + D C EP++ G +P + ++ P P+ + H+P+PL
Sbjct: 221 RRPDCRDMS-DELNCEEPVL-GISPTFSLLVETTSLPPRPETTIMRQPPVTHAPQPLLPG 278
Query: 749 RNPPPPCSP 757
P PC P
Sbjct: 279 SVRPLPCGP 287
Score = 32.3 bits (72), Expect = 1.7
Identities = 22/79 (27%), Positives = 32/79 (40%), Gaps = 7/79 (8%)
Query: 389 QGC--FSEPQRCD----GWWHCASGRDEQGCPACPPDQYPCEGGSG-LCYTPADRCNNQK 441
QGC +E RC+ G++ A Q C CP P G + C+ D
Sbjct: 1176 QGCQHHTEGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAGQAAHTCFLDTDGHPTCD 1235
Query: 442 SCPDGADEKNCFSCQPGTF 460
+C G ++C C PG +
Sbjct: 1236 ACSPGHSGRHCERCAPGYY 1254
>gi|126091152 cubilin [Homo sapiens]
Length = 3623
Score = 85.1 bits (209), Expect = 2e-16
Identities = 89/361 (24%), Positives = 137/361 (37%), Gaps = 50/361 (13%)
Query: 43 CSGKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSLD 102
C G L T G SP +P+ Y + C W+++ G + F++F +E C+LD
Sbjct: 1165 CGGNL---TTSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPNCTLD 1221
Query: 103 WLLL--GPAAPPRQEAFRLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYIRGK 160
+L + GP++ +LCG PP S+ D ++I +D G +GF+ Y R
Sbjct: 1222 YLAVYDGPSSNSHL-LTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQG--RGFKAEY-RQT 1277
Query: 161 LGQASCQADEFRCDNGKCLPGPW----QCNTVDECGDGSDEG------------NCSAPA 204
+ P P+ CN G+ NCS
Sbjct: 1278 CENVVIVNQTYGILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFDLEHHINCSTDY 1337
Query: 205 SE------PPGSLCPGGTFPCSGARSTRCLPVERRCDGLQDCGDGSDEAGCP----DLAC 254
E G C G P G+ ++ L V DG+ G E G C
Sbjct: 1338 LELYDGPRQMGRYC-GVDLPPPGSTTSSKLQVLLLTDGV-----GRREKGFQMQWFVYGC 1391
Query: 255 GRRLGSFYGSFASPDLFGAARGPSDLHCTWLVDTQDSRRVLLQL-ELRLGYD-----DYV 308
G L GSF+SP R P + C W + T + L + + + Y D +
Sbjct: 1392 GGELSGATGSFSSPGF--PNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVL 1449
Query: 309 QVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQGRLTVAYHARARSAGHGFNATYQ-VKGY 367
++Y G R+ Q + RS P+ + + L + + G GFNA++Q V G
Sbjct: 1450 EIYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNASWQAVTGG 1509
Query: 368 C 368
C
Sbjct: 1510 C 1510
Score = 67.4 bits (163), Expect = 5e-11
Identities = 37/126 (29%), Positives = 63/126 (50%), Gaps = 6/126 (4%)
Query: 34 SSAVPALAACSGKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDV 93
++ +++AC G G+ SP +P YPP C W I G+ + +SF +F +
Sbjct: 1729 TTVTASVSACGGTFYM---AEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISFQL 1785
Query: 94 EESHQCSLDWLLLGPAAPPRQEAFRLCGSAIPPAFISARDH-VWIFFHSDASSSGQAQGF 152
E+S CS D++ + R CG++ P + S H +W+ F SD S SG GF
Sbjct: 1786 EDSQDCSRDFVEIREGNATGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSG--TGF 1843
Query: 153 RLSYIR 158
+ ++++
Sbjct: 1844 QATFMK 1849
Score = 59.3 bits (142), Expect = 1e-08
Identities = 33/106 (31%), Positives = 54/106 (50%), Gaps = 3/106 (2%)
Query: 51 TERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSLDWLLLGPAA 110
TE G I SP P YP G NC+W+I +I + F F +E + C+ D+L +
Sbjct: 937 TESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLEFHYNCTNDYLEVYD-T 995
Query: 111 PPRQEAFRLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSY 156
R CG +IPP+ S+ + + + F +D+ + +GF ++Y
Sbjct: 996 DSETSLGRYCGKSIPPSLTSSGNSLMLVFVTDSDLA--YEGFLINY 1039
Score = 55.8 bits (133), Expect = 1e-07
Identities = 49/153 (32%), Positives = 71/153 (46%), Gaps = 17/153 (11%)
Query: 43 CSGKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSLD 102
C G+L T G SP +P YPP C WYI+ D G I ++ +FDVE +C+ D
Sbjct: 1391 CGGELSGAT---GSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFD 1447
Query: 103 WLLL--GPAAPPRQEAFRLCGSAIP--PAFISAR-DHVWIFFHSDASSSGQAQGFRLSY- 156
L + GP + A +LC P P +S+ + + I F +D S +G +GF S+
Sbjct: 1448 VLEIYGGPDFHSPRIA-QLCTQRSPENPMQVSSTGNELAIRFKTDLSING--RGFNASWQ 1504
Query: 157 --IRGKLGQASCQADEFRCDNGKCLPGPWQCNT 187
G G + E N P P++ NT
Sbjct: 1505 AVTGGCGGIFQAPSGEIHSPN---YPSPYRSNT 1534
Score = 55.5 bits (132), Expect = 2e-07
Identities = 39/133 (29%), Positives = 60/133 (45%), Gaps = 7/133 (5%)
Query: 55 GVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSLDWLLLGPAAPPRQ 114
GVI SP +P Y T+CS ++ +G IT++F +FD+E C+ D + + P
Sbjct: 2698 GVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSVTVRNGGSPES 2757
Query: 115 EAF-RLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYIRGKLGQASCQADEFRC 173
+ CG++ P S + + + F+SD S G GF ++ LG F
Sbjct: 2758 PIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQG--GGFYATWNTQTLGCGGI----FHS 2811
Query: 174 DNGKCLPGPWQCN 186
DNG W N
Sbjct: 2812 DNGTIRSPHWPQN 2824
Score = 54.7 bits (130), Expect = 3e-07
Identities = 39/113 (34%), Positives = 56/113 (49%), Gaps = 6/113 (5%)
Query: 42 ACSGKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRG-DMITISFRNFDVEESHQCS 100
AC G + T + SP +P NYP NCSW IQ + IT+SF +F++E S C+
Sbjct: 1619 ACGGHIL--TSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHITLSFTHFELERSTTCA 1676
Query: 101 LDWL-LLGPAAPPRQEAFRLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGF 152
D++ +L R CG+ +P S + + F SD+S S A GF
Sbjct: 1677 RDFVEILDGGHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSIS--AGGF 1727
Score = 54.7 bits (130), Expect = 3e-07
Identities = 35/119 (29%), Positives = 60/119 (50%), Gaps = 6/119 (5%)
Query: 39 ALAACSGKLEQHTERRGVIYSPAWP-LNYPPGTNCSWYIQGDRGDMITISFRNFDVEESH 97
++A C G++ + GV+ S P L Y C W++QG G +TISF +F+++ S
Sbjct: 2332 SIAQCGGRVPGQS---GVVESIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSS 2388
Query: 98 QCSLDWLLLGPAAPPRQEAFRLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSY 156
C D++ + R CG+ IP + ++ + + F +D S + A GFRL +
Sbjct: 2389 GCEKDFVEIWDNHTSGNILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVT--ASGFRLRF 2445
Score = 54.3 bits (129), Expect = 4e-07
Identities = 36/117 (30%), Positives = 54/117 (46%), Gaps = 8/117 (6%)
Query: 43 CSGKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSLD 102
C G L T G I SP +P NYPPG +C W + ++T +F +E C+ D
Sbjct: 590 CGGIL---TGPYGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKD 646
Query: 103 WLLLGPAAPPRQEAF--RLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYI 157
+L + P Q+ + C + P + I FHSD+ S QGF ++Y+
Sbjct: 647 YLEIRD-GPLYQDPLLGKFCTTFSVPPLQTTGPFARIHFHSDSQISD--QGFHITYL 700
Score = 53.1 bits (126), Expect = 9e-07
Identities = 32/106 (30%), Positives = 52/106 (49%), Gaps = 2/106 (1%)
Query: 39 ALAACSGKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEES-H 97
A++A + L+ +T+ G SP +P NYP C + I G +I + F NF +EE+
Sbjct: 1041 AISAATACLQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIG 1100
Query: 98 QCSLDWLLLGPAAPPRQEAFRL-CGSAIPPAFISARDHVWIFFHSD 142
D+L + + + GS +PP IS + +W+ F SD
Sbjct: 1101 NYYTDFLEIRDGGYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSD 1146
Score = 52.4 bits (124), Expect = 2e-06
Identities = 34/124 (27%), Positives = 59/124 (47%), Gaps = 5/124 (4%)
Query: 42 ACSGKLEQH-TERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRN-FDVEESHQC 99
AC G + H + G + SP P NYPP +C W + I + F + FD+E + C
Sbjct: 2216 ACGGNVYIHDADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIEVTPNC 2275
Query: 100 SLDWLLLGPAAPPRQEAF-RLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYIR 158
+ ++L L + CG+++P + S+ + +++ F SD +S GF+ Y
Sbjct: 2276 TSNYLELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSD--NSPTHVGFKAKYSI 2333
Query: 159 GKLG 162
+ G
Sbjct: 2334 AQCG 2337
Score = 52.0 bits (123), Expect = 2e-06
Identities = 31/105 (29%), Positives = 50/105 (47%), Gaps = 4/105 (3%)
Query: 54 RGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSLDWLLL--GPAAP 111
RG SP +P YP T C W + G ++TI+F +++ C ++L L GP A
Sbjct: 3519 RGSFTSPGYPGTYPNNTYCEWVLVAPAGRLVTINFYFISIDDPGDCVQNYLTLYDGPNAS 3578
Query: 112 PRQEAFRLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSY 156
G F+++ + V+I FH+D + A FRL++
Sbjct: 3579 SPSSGPYCGGDTSIAPFVASSNQVFIKFHADYARRPSA--FRLTW 3621
Score = 51.6 bits (122), Expect = 3e-06
Identities = 39/126 (30%), Positives = 59/126 (46%), Gaps = 17/126 (13%)
Query: 42 ACSGKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRN-FDVEE-SHQC 99
+C G L H +R G+I SP +P YP NCSW++ G I + F F + C
Sbjct: 2091 SCGGYL--HADR-GIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSC 2147
Query: 100 SL-DWLLL--------GPAAPPRQEAFRLCGSAIPPAFISARDHVWIFFHSDASSSGQAQ 150
+ D+L+L P PP CGS ++ + +++ F SD S+ G Q
Sbjct: 2148 NQGDYLVLRNGPDICSPPLGPPGGNG-HFCGSHASSTLFTSDNQMFVQFISDHSNEG--Q 2204
Query: 151 GFRLSY 156
GF++ Y
Sbjct: 2205 GFKIKY 2210
Score = 50.4 bits (119), Expect = 6e-06
Identities = 94/392 (23%), Positives = 135/392 (34%), Gaps = 66/392 (16%)
Query: 24 LVNIFLTGRLSSAVPALA--ACSGKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRG 81
L+ F +P +A AC G L + ++SP WP +Y +C+W IQ
Sbjct: 1957 LLEWFAVDAPDGVLPTIAPGACGGFLRTG-DAPVFLFSPGWPDSYSNRVDCTWLIQAP-D 2014
Query: 82 DMITISFRNFDVEESHQCSLDWLLLGPAAPP-RQEAFRLCGSAIPPAFISARDHVWIFFH 140
+ ++ + D+E C+ D L++ Q+ LCG IP S ++++I F
Sbjct: 2015 STVELNILSLDIESHRTCAYDSLVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFT 2074
Query: 141 SDASSSGQAQGFRLSYIRGKLGQ--------ASCQADEFRCDNGKC-------------- 178
SD SS GF S+ + G S + E N C
Sbjct: 2075 SD--SSVTRAGFNASFHKSCGGYLHADRGIITSPKYPETYPSNLNCSWHVLVQSGLTIAV 2132
Query: 179 -------LP-GPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARSTRCLPV 230
+P G CN D + CS P P G+ G F S A ST L
Sbjct: 2133 HFEQPFQIPNGDSSCNQGDYLVLRNGPDICSPPLGPPGGN----GHFCGSHASST--LFT 2186
Query: 231 ERRCDGLQDCGDGSDEA-------GCPDLACGRRLGSFYGSFASPDLFGAARGPSDLH-- 281
+Q D S+E LACG G+ Y D G P+ H
Sbjct: 2187 SDNQMFVQFISDHSNEGQGFKIKYEAKSLACG---GNVY--IHDADSAGYVTSPNHPHNY 2241
Query: 282 -----CTWLVDTQDSRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSL 336
C W++ R+ LQ E R + E D + S SL
Sbjct: 2242 PPHADCIWILAAPPETRIQLQFEDRFDIEVTPNCTSNYLELRDGVDSDAPILSKFCGTSL 2301
Query: 337 EAAQGRLTVAYHARARSAGH----GFNATYQV 364
++Q + R RS GF A Y +
Sbjct: 2302 PSSQWSSGEVMYLRFRSDNSPTHVGFKAKYSI 2333
Score = 49.3 bits (116), Expect = 1e-05
Identities = 30/103 (29%), Positives = 50/103 (48%), Gaps = 3/103 (2%)
Query: 55 GVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSLDWLLLGPAA-PPR 113
GVI SP +P YP C W I + +I ++F F++ S C D++ +G ++
Sbjct: 825 GVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIGSSAHCETDYVEIGSSSILGS 884
Query: 114 QEAFRLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSY 156
E + CG+ IP S + +++ F SSS + GF +
Sbjct: 885 PENKKYCGTDIPSFITSVYNFLYVTFVK--SSSTENHGFMAKF 925
Score = 48.5 bits (114), Expect = 2e-05
Identities = 33/114 (28%), Positives = 57/114 (50%), Gaps = 4/114 (3%)
Query: 55 GVIYSPAWPL-NYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSLDWLLLGPAAPPR 113
G+I SPA+ +YP +C + I +I + F +FDV S CS D+L + A
Sbjct: 3046 GIITSPAYSYADYPNDMHCLYTITVSDDKVIELKFSDFDVVPSTSCSHDYLAIYDGANTS 3105
Query: 114 QEAF-RLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYIRGKLGQASC 166
+ CGS PP S+ + + + F +D+ + A+G+++S+ + Q C
Sbjct: 3106 DPLLGKFCGSKRPPNVKSSNNSMLLVFKTDSFQT--AKGWKMSFRQTLGPQQGC 3157
Score = 48.1 bits (113), Expect = 3e-05
Identities = 29/103 (28%), Positives = 50/103 (48%), Gaps = 6/103 (5%)
Query: 55 GVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSLDWLLLGPAAPPRQ 114
G I+SP +P Y T+CSW I+ DR + ++F +FD+E C + + +
Sbjct: 1519 GEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQDSCIMAY---DGLSSTMS 1575
Query: 115 EAFRLCG-SAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSY 156
R CG + +S+ + +++ F S S Q +GFR +
Sbjct: 1576 RLARTCGREQLANPIVSSGNSLFLRFQS--GPSRQNRGFRAQF 1616
Score = 46.6 bits (109), Expect = 9e-05
Identities = 32/104 (30%), Positives = 49/104 (47%), Gaps = 6/104 (5%)
Query: 55 GVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSLDWLLL--GPAAPP 112
G + SP WP NYP +N W + + ++ D+EE C D L + GP+
Sbjct: 1861 GKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDGPSIHA 1920
Query: 113 RQEAFRLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSY 156
R CG+ +F S + + F+SD+S SG +GF L +
Sbjct: 1921 RLIG-AYCGTQ-TESFSSTGNSLTFHFYSDSSISG--KGFLLEW 1960
Score = 44.3 bits (103), Expect = 4e-04
Identities = 23/93 (24%), Positives = 45/93 (48%), Gaps = 1/93 (1%)
Query: 55 GVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSLDWLLLGPAAPPRQ 114
G + SP WP NY +C+ + + I++ F + +E S +C D+L + +
Sbjct: 3404 GNLRSPGWPDNYDNDKDCTVTLTAPQNHTISLFFHSLGIENSVECRNDFLEVRNGSNSNS 3463
Query: 115 EAF-RLCGSAIPPAFISARDHVWIFFHSDASSS 146
+ CG+ +P S + +++ F SD+ +S
Sbjct: 3464 PLLGKYCGTLLPNPVFSQNNELYLRFKSDSVTS 3496
Score = 41.2 bits (95), Expect = 0.004
Identities = 30/107 (28%), Positives = 44/107 (41%), Gaps = 7/107 (6%)
Query: 55 GVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISF-RNFDVEESH-QCSLDWLLLGPAAPP 112
G I SP WP N+P + CSW + + ISF NF + QC ++ +
Sbjct: 2814 GTIRSPHWPQNFPENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNSFVKVWAGTEE 2873
Query: 113 RQEAFRL--CGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYI 157
+A CG+ P I+ + F S AQGF S++
Sbjct: 2874 VDKALLATGCGNVAPGPVITPSNTFTAVFQ---SQEAPAQGFSASFV 2917
Score = 40.8 bits (94), Expect = 0.005
Identities = 38/151 (25%), Positives = 65/151 (43%), Gaps = 28/151 (18%)
Query: 64 LNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSLDWLLL--GPAAPPRQEAFRLCG 121
+ Y NC W I+ + G ++ I+F F +E C ++L + G ++ Q R CG
Sbjct: 492 VGYVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNCPHEFLQVYDGDSSSAFQLG-RFCG 550
Query: 122 SAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYIRGKLGQASCQADEFRCDNGKCLPG 181
S++P +S+ + ++ +S+ +G +GF +R + Q C G L G
Sbjct: 551 SSLPHELLSSDNALYFHLYSEHLRNG--RGFT---VRWETQQPEC---------GGILTG 596
Query: 182 PWQCNTVDECGDGSDEGNCSAPASEPPGSLC 212
P+ G G P + PPG C
Sbjct: 597 PY--------GSIKSPG---YPGNYPPGRDC 616
Score = 39.3 bits (90), Expect = 0.014
Identities = 34/139 (24%), Positives = 56/139 (40%), Gaps = 20/139 (14%)
Query: 250 PDLACGRRLGSFYGSFASPDLFGAARGPSDLHCTWLVDTQDSRRVLLQLEL--------- 300
P CG L +FASPD +L+C W++ ++ + L
Sbjct: 3153 PQQGCGGYLTGSNNTFASPDSDSNGMYDKNLNCVWIIIAPVNKVIHLTFNTFALEAASTR 3212
Query: 301 -RLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQGRLTVAYHARARSAGHGFN 359
R Y DYV++Y+G E + ++ + P ++ LTV + + GFN
Sbjct: 3213 QRCLY-DYVKLYDGDSENAN---LAGTFCGSTVPAPFISSGNFLTVQFISDLTLEREGFN 3268
Query: 360 ATYQVKGYCLPWEQPCGSS 378
ATY + + PCG +
Sbjct: 3269 ATYTI------MDMPCGGT 3281
Score = 38.1 bits (87), Expect = 0.031
Identities = 26/95 (27%), Positives = 43/95 (45%), Gaps = 6/95 (6%)
Query: 66 YPPGTNCSWYIQGDRGDMITISFRNFDVEES---HQCSLDWLLLGPAAPPRQE-AFRLCG 121
Y NC W I +I ++F F +E + +C D++ L A CG
Sbjct: 3179 YDKNLNCVWIIIAPVNKVIHLTFNTFALEAASTRQRCLYDYVKLYDGDSENANLAGTFCG 3238
Query: 122 SAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSY 156
S +P FIS+ + + + F SD + + +GF +Y
Sbjct: 3239 STVPAPFISSGNFLTVQFISDLTL--EREGFNATY 3271
Score = 35.0 bits (79), Expect = 0.26
Identities = 78/367 (21%), Positives = 124/367 (33%), Gaps = 70/367 (19%)
Query: 38 PALAACSGKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESH 97
P+ C G +T+ G ++ P + C + ++ +G+ I I+F + +++
Sbjct: 703 PSDLRCGGN---YTDPEGELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQS 759
Query: 98 QCSLDWL-------LLGPAAPPRQEAFRLCGSAIPPAFISARDHVWIFFHSDASSSGQAQ 150
S +++ LLG ++CG+ S + VWI F DAS +
Sbjct: 760 DSSQNYIEVRDGETLLG----------KVCGNGTISHIKSITNSVWIRFKIDASV--EKA 807
Query: 151 GFRLSYIRGKLGQASCQADEFRCDN-------GKCLPGPWQCN---------------TV 188
FR Y Q +C DE + PG C TV
Sbjct: 808 SFRAVY------QVAC-GDELTGEGVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTV 860
Query: 189 DECGDGSD------EGNCSAPASEPPGSLCPGGTFPCSGARSTRCLPVERRCDGLQDCGD 242
E G + E S+ P G P L V +
Sbjct: 861 FEIGSSAHCETDYVEIGSSSILGSPENKKYCGTDIPSFITSVYNFLYVTFVKSSSTENHG 920
Query: 243 GSDEAGCPDLACGRRLGSFYGSFASPDLFGAARGPSDLHCTWLVDTQDSRRVLLQLE--- 299
+ DLACG L G+ SP P ++CTW + Q + + L E
Sbjct: 921 FMAKFSAEDLACGEILTESTGTIQSPGHPNVY--PHGINCTWHILVQPNHLIHLMFETFH 978
Query: 300 LRLGY---DDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQGRLTVAYHARARSAGH 356
L Y +DY++VY+ D Y P SL ++ L + + + A
Sbjct: 979 LEFHYNCTNDYLEVYD-----TDSETSLGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYE 1033
Query: 357 GFNATYQ 363
GF Y+
Sbjct: 1034 GFLINYE 1040
Score = 33.9 bits (76), Expect = 0.59
Identities = 29/120 (24%), Positives = 48/120 (40%), Gaps = 7/120 (5%)
Query: 39 ALAACSGKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQ 98
++ C G L+ G SP +P P G C W I G IT+ F N +
Sbjct: 2448 SMEECGGDLQGSI---GTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPS 2504
Query: 99 CSLDWLLL-GPAAPPRQEAFRLCGSA-IPPAFISARDHVWIFFHSDASSSGQAQGFRLSY 156
C+ + +++ + +LC S + S+ + + + F +D S GF SY
Sbjct: 2505 CNNEHVIVFNGIRSNSPQLEKLCSSVNVSNEIKSSGNTMKVIFFTDGSR--PYGGFTASY 2562
Score = 33.5 bits (75), Expect = 0.77
Identities = 30/153 (19%), Positives = 60/153 (39%), Gaps = 25/153 (16%)
Query: 252 LACGRRLGSFYGSFASPDLFGAARGPSDLHCTWLVDTQDSRRVLLQLELRLGYD------ 305
++CG G SP + A P+D+HC + + D + + L+ +D
Sbjct: 3035 ISCGGVFNFSSGIITSP-AYSYADYPNDMHCLYTITVSDDKVIELKFS---DFDVVPSTS 3090
Query: 306 ---DYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQGRLTVAYHARARSAGHGFNATY 362
DY+ +Y+G D LL + + RP +++++ + + + ++
Sbjct: 3091 CSHDYLAIYDG-ANTSDPLLG--KFCGSKRPPNVKSSNNSMLLVFKT---------DSFQ 3138
Query: 363 QVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEP 395
KG+ + + Q G G G F+ P
Sbjct: 3139 TAKGWKMSFRQTLGPQQGCGGYLTGSNNTFASP 3171
>gi|61744467 low density lipoprotein receptor-related protein 8
isoform 3 precursor [Homo sapiens]
Length = 700
Score = 84.3 bits (207), Expect = 4e-16
Identities = 44/128 (34%), Positives = 58/128 (45%), Gaps = 9/128 (7%)
Query: 372 EQPCGSSSDSDGGSLGDQG-CFSEPQRCDGWWHCASGRDEQGCPA----CPPDQYPCEGG 426
E C + +D D G C E +CDG C G DE CP ++ C
Sbjct: 78 EDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPT 137
Query: 427 SGLCYTPADRCNNQKSCPDGADEKNCFS----CQPGTFHCGTNLCIFETWRCDGQEDCQD 482
S C + RC+ +K C GADE C + C+ F CG C+ C+ ++DC D
Sbjct: 138 SHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPD 197
Query: 483 GSDEHGCL 490
GSDE GCL
Sbjct: 198 GSDEAGCL 205
Score = 78.6 bits (192), Expect = 2e-14
Identities = 35/85 (41%), Positives = 47/85 (55%), Gaps = 6/85 (7%)
Query: 165 SCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARS 224
+C +F CDNG C+ W+C+ +EC DGSDE + +CP C G S
Sbjct: 85 TCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTK-----QVCPAEKLSC-GPTS 138
Query: 225 TRCLPVERRCDGLQDCGDGSDEAGC 249
+C+P RCDG +DC G+DEAGC
Sbjct: 139 HKCVPASWRCDGEKDCEGGADEAGC 163
Score = 74.7 bits (182), Expect = 3e-13
Identities = 36/114 (31%), Positives = 55/114 (48%), Gaps = 10/114 (8%)
Query: 388 DQGCFSEPQRCDGWWHCASGRDEQGCP--ACPPDQYPCEGGSGLCYTPADRCNNQKSCPD 445
++ C RCD C DE CP C + C+ G C +C+ ++ CPD
Sbjct: 56 NERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGH--CIHERWKCDGEEECPD 113
Query: 446 GADEKNCFS----CQPGTFHCG--TNLCIFETWRCDGQEDCQDGSDEHGCLAAV 493
G+DE C CG ++ C+ +WRCDG++DC+ G+DE GC ++
Sbjct: 114 GSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSL 167
Score = 63.9 bits (154), Expect = 5e-10
Identities = 29/73 (39%), Positives = 37/73 (50%), Gaps = 4/73 (5%)
Query: 416 CPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNC--FSCQPGTFHCGTNLCIFETWR 473
C DQ+ C C RC+ C D +DE +C +C F C CI E W+
Sbjct: 47 CEKDQFQCRNER--CIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWK 104
Query: 474 CDGQEDCQDGSDE 486
CDG+E+C DGSDE
Sbjct: 105 CDGEEECPDGSDE 117
Score = 61.2 bits (147), Expect = 3e-09
Identities = 30/86 (34%), Positives = 42/86 (48%), Gaps = 10/86 (11%)
Query: 166 CQADEFRCD--NGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGAR 223
C A++ C + KC+P W+C+ +C G+DE C+ C G F C
Sbjct: 127 CPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSL-----GTCRGDEFQCGDG- 180
Query: 224 STRCLPVERRCDGLQDCGDGSDEAGC 249
C+ + C+ QDC DGSDEAGC
Sbjct: 181 --TCVLAIKHCNQEQDCPDGSDEAGC 204
Score = 46.6 bits (109), Expect = 9e-05
Identities = 35/107 (32%), Positives = 47/107 (43%), Gaps = 13/107 (12%)
Query: 165 SCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARS 224
+C+ DEF+C +G C+ CN +C DGSDE C +E C CS +
Sbjct: 169 TCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNE-----CLHNNGGCSHICT 223
Query: 225 TRCLPVERRCD-GLQ-----DCGDGSDEAGCPDLACGRRLGSFYGSF 265
+ E C G Q CGD DE PD AC + ++ G F
Sbjct: 224 DLKIGFECTCPAGFQLLDQKTCGD-IDECKDPD-ACSQICVNYKGYF 268
Score = 42.4 bits (98), Expect = 0.002
Identities = 16/35 (45%), Positives = 18/35 (51%)
Query: 455 CQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGC 489
C+ F C CI WRCD +DC D SDE C
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC 81
>gi|66082554 low density lipoprotein receptor-related protein 8
isoform 2 precursor [Homo sapiens]
Length = 793
Score = 78.6 bits (192), Expect = 2e-14
Identities = 35/85 (41%), Positives = 47/85 (55%), Gaps = 6/85 (7%)
Query: 165 SCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARS 224
+C +F CDNG C+ W+C+ +EC DGSDE + +CP C G S
Sbjct: 85 TCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTK-----QVCPAEKLSC-GPTS 138
Query: 225 TRCLPVERRCDGLQDCGDGSDEAGC 249
+C+P RCDG +DC G+DEAGC
Sbjct: 139 HKCVPASWRCDGEKDCEGGADEAGC 163
Score = 74.3 bits (181), Expect = 4e-13
Identities = 36/110 (32%), Positives = 53/110 (48%), Gaps = 10/110 (9%)
Query: 388 DQGCFSEPQRCDGWWHCASGRDEQGCP--ACPPDQYPCEGGSGLCYTPADRCNNQKSCPD 445
++ C RCD C DE CP C + C+ G C +C+ ++ CPD
Sbjct: 56 NERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGH--CIHERWKCDGEEECPD 113
Query: 446 GADEKNCFS----CQPGTFHCG--TNLCIFETWRCDGQEDCQDGSDEHGC 489
G+DE C CG ++ C+ +WRCDG++DC+ G+DE GC
Sbjct: 114 GSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC 163
Score = 63.9 bits (154), Expect = 5e-10
Identities = 29/73 (39%), Positives = 37/73 (50%), Gaps = 4/73 (5%)
Query: 416 CPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNC--FSCQPGTFHCGTNLCIFETWR 473
C DQ+ C C RC+ C D +DE +C +C F C CI E W+
Sbjct: 47 CEKDQFQCRNER--CIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWK 104
Query: 474 CDGQEDCQDGSDE 486
CDG+E+C DGSDE
Sbjct: 105 CDGEEECPDGSDE 117
Score = 42.4 bits (98), Expect = 0.002
Identities = 16/35 (45%), Positives = 18/35 (51%)
Query: 455 CQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGC 489
C+ F C CI WRCD +DC D SDE C
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC 81
Score = 39.7 bits (91), Expect = 0.011
Identities = 32/108 (29%), Positives = 47/108 (43%), Gaps = 15/108 (13%)
Query: 166 CQADEFRCD--NGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGAR 223
C A++ C + KC+P W+C+ +C G+DE C+ +E C CS
Sbjct: 127 CPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATWLNE-----CLHNNGGCSHIC 181
Query: 224 STRCLPVERRCD-GLQ-----DCGDGSDEAGCPDLACGRRLGSFYGSF 265
+ + E C G Q CGD DE PD AC + ++ G F
Sbjct: 182 TDLKIGFECTCPAGFQLLDQKTCGD-IDECKDPD-ACSQICVNYKGYF 227
>gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo
sapiens]
Length = 3538
Score = 78.2 bits (191), Expect = 3e-14
Identities = 87/331 (26%), Positives = 136/331 (41%), Gaps = 53/331 (16%)
Query: 21 VVCLVNIFLTGRLSSAVP---ALAACSGKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQ 77
+ C+ N T VP A AC G + + G+I SP++P Y +C+W I
Sbjct: 216 LTCIANSVNTASWDFPVPICRAEDACGGTMRGSS---GIISSPSFPNEYHNNADCTWTIV 272
Query: 78 GDRGDMITISFRNFDVEESHQCSLDWLLLGPAAPPRQEAFRLCGSAIPPAFISARDHVWI 137
+ GD I++ F +F +EE + D+L + + PP L G IPP IS ++ W+
Sbjct: 273 AEPGDTISLIFTDFQMEEKY----DYLEIEGSEPP---TIWLSGMNIPPPIISNKN--WL 323
Query: 138 FFHSDASSSGQAQGFRLSYIRGKLGQASCQADEFRCDNGKCLPGPWQCN---TVDECGDG 194
H S+ + +GF Y K A +F+ K PG N ++E G
Sbjct: 324 RLHFVTDSNHRYRGFSAPYQVKK-------AIDFKSRGFKLFPGKDNSNKFSILNEGGIK 376
Query: 195 SDEGNCSAPASEPPG-------SLCPGGTFPC------SGARSTRCLPVERRCDGLQDCG 241
+ C P G SL F C GA+S C + D
Sbjct: 377 TASNLCPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSD-- 434
Query: 242 DGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARGPSDLHCTWLVDTQDSRRVLL----Q 297
C CG L G+F SP+ + S+ C W++ ++ +V+ +
Sbjct: 435 ---HRPVCKVKTCGSNLQGPSGTFTSPNF--PFQYDSNAQCVWVITAVNTNKVIQINFEE 489
Query: 298 LELRLGYDDYVQVYEGLGERGD--RLLQTLS 326
+L +GYD + + +G GE GD +LQ L+
Sbjct: 490 FDLEIGYDT-LTIGDG-GEVGDPRTVLQVLT 518
Score = 62.0 bits (149), Expect = 2e-09
Identities = 87/378 (23%), Positives = 134/378 (35%), Gaps = 65/378 (17%)
Query: 47 LEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSLDWLLL 106
L T G + SP +P Y NC W I D G I +SF +FD+E D+L +
Sbjct: 618 LSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLES----QFDFLAV 673
Query: 107 GPAAPPRQEAFRLCGSAIPPAFISARDHVW-IFFHSDASSSGQAQGFRLSYIRGKLGQAS 165
P A P+ +++ H+ + F +D S SG +GF ++Y G
Sbjct: 674 KDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSG--RGFNITY--NTFGHNE 729
Query: 166 CQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARST 225
C P P GD G+ + +C G G +
Sbjct: 730 C-------------PDPGIPINARRFGDNFQLGSSIS-------VICEEGFIKTQGTETI 769
Query: 226 RCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARGPSDLHCTWL 285
C+ + DG + G P CG + G SP G + L+C W+
Sbjct: 770 TCILM----DGKVMWSGLIPKCGAP---CGGHFSAPSGVILSPGWPGYYK--DSLNCEWV 820
Query: 286 VDTQDSRRVLLQLE---LRLGYDDYVQVYEGLGERGDRLLQTL--SYRSNHRPVSLEAAQ 340
++ + + + E L Y D ++V++ G LL L SY P L ++
Sbjct: 821 IEAEPGHSIKITFERFQTELNY-DVLEVHD-----GPNLLSPLLGSYNGTQVPQFLFSSS 874
Query: 341 GRLTVAYHARARSAGHGFNATYQ---VKGY-CLPWEQPCGSSSDSDGGSLGDQGCFS--- 393
+ + + + +GF Y+ V Y CL P S+G FS
Sbjct: 875 NFIYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPGIPVHGRRYGHDFSIGSTVSFSCDS 934
Query: 394 -------EPQRCD--GWW 402
EP C+ WW
Sbjct: 935 GYRLSHEEPLLCEKNHWW 952
Score = 59.7 bits (143), Expect = 1e-08
Identities = 87/327 (26%), Positives = 124/327 (37%), Gaps = 48/327 (14%)
Query: 40 LAACSGKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQC 99
+ C G L T+R+G I SP +P Y NC W I G I + +F E +
Sbjct: 1832 IVPCGGIL---TKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWD- 1887
Query: 100 SLDWLLLGPAAPPRQEAFRLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYIRG 159
SLD+ G PR ++ G+ IP S +++++ F SD S S A GF L Y
Sbjct: 1888 SLDFYDGGDNNAPRLGSY--SGTTIPHLLNSTSNNLYLNFQSDISVS--AAGFHLEYT-- 1941
Query: 160 KLGQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPC 219
+G SC P P ++ + GD G+ + + SL C
Sbjct: 1942 AIGLDSC-------------PEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITC 1988
Query: 220 SGARSTRCLPVERRCDGLQDCGDGSDEAGCPDLA-CGRRLGSFYGSFASPDLFGAARGPS 278
PV R + C LA CG + F G SP G PS
Sbjct: 1989 MPG------PVRRWNYPIPIC-----------LAQCGGAMSDFSGVILSPGFPG--NYPS 2029
Query: 279 DLHCTWLVDTQDSRRVLLQLE--LRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSL 336
L CTW ++ V LQ DY++V G E ++ LS P SL
Sbjct: 2030 SLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSGSSET-STVIGRLS--GPQIPSSL 2086
Query: 337 EAAQGRLTVAYHARARSAGHGFNATYQ 363
+ ++ +H+ GF+ YQ
Sbjct: 2087 FSTTHETSLYFHSDYSQNKQGFHIVYQ 2113
Score = 58.9 bits (141), Expect = 2e-08
Identities = 73/320 (22%), Positives = 117/320 (36%), Gaps = 50/320 (15%)
Query: 40 LAACSGKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQC 99
LA C G + + GVI SP +P NYP +C+W I G + + F NF E H
Sbjct: 2004 LAQCGGAMSDFS---GVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIH-- 2058
Query: 100 SLDWLLLGPAAPPRQEAF-RLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYIR 158
D+L + + RL G IP + S ++FHSD S + QGF + Y
Sbjct: 2059 --DYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQN--KQGFHIVYQA 2114
Query: 159 GKLGQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFP 218
+L SC P P G+ G + P +L
Sbjct: 2115 YQL--QSC-------------PDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALT 2159
Query: 219 CSGARSTRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARGPS 278
C S RC+ L CG + + G+ SP P+
Sbjct: 2160 CLHGVSRNWNHPLPRCEAL----------------CGGNITAMNGTIYSPGY--PDEYPN 2201
Query: 279 DLHCTWLVDTQDSRRVLLQ---LELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVS 335
C WLV + + L+ Y D++ V++G + ++ Q + N S
Sbjct: 2202 FQDCFWLVRVPPGNGIYINFTVLQTEPIY-DFITVWDGPDQNSPQIGQ---FSGNTALES 2257
Query: 336 LEAAQGRLTVAYHARARSAG 355
+ + ++ + +H+ ++G
Sbjct: 2258 VYSTSNQILIKFHSDFTTSG 2277
Score = 57.8 bits (138), Expect = 4e-08
Identities = 74/333 (22%), Positives = 119/333 (35%), Gaps = 54/333 (16%)
Query: 40 LAACSGKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQC 99
+A C G+ + E G I SP +P Y C W I+ D G+++++ F FD E SH
Sbjct: 1307 IAECGGRFKG--ESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDI 1364
Query: 100 SLDWLLLGPAAPPRQEAF--RLCGSAIPPAFISARDHVWIFFHSD--ASSSGQAQGFRLS 155
W PP + + GS IP S + V I F +D S SG A F S
Sbjct: 1365 LRVW-----DGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSS 1419
Query: 156 YIRGKLGQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGG 215
+C+ D G + G GDG + G+ +P
Sbjct: 1420 V------ATACR------DPGVPMNG-------TRNGDGREPGDTVVFQCDP-------- 1452
Query: 216 TFPCSGARSTRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAAR 275
+ G C+ VE R CG L G SP+
Sbjct: 1453 GYELQGEERITCIQVENRY-------FWQPSPPVCIAPCGGNLTGSSGFILSPNF--PHP 1503
Query: 276 GPSDLHCTWLVDTQDSRRV---LLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHR 332
P C W + + + + Y D++ +Y+G + S++ +
Sbjct: 1504 YPHSRDCDWTITVNADYVISLAFISFSIEPNY-DFLYIYDGPDSNSPLI---GSFQDSKL 1559
Query: 333 PVSLEAAQGRLTVAYHARARSAGHGFNATYQVK 365
P +E++ + +A+ + + GF+ Y+ K
Sbjct: 1560 PERIESSSNTMHLAFRSDGSVSYTGFHLEYKAK 1592
Score = 55.8 bits (133), Expect = 1e-07
Identities = 42/125 (33%), Positives = 60/125 (48%), Gaps = 12/125 (9%)
Query: 43 CSGKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSLD 102
C G L+ G I SP +P YP G NC+W I + + I I F++F +EE + D
Sbjct: 65 CGGTLKG---LNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEY----D 117
Query: 103 WLLLGPAAP-PRQEAFRLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYIRGKL 161
+L L P P RL G +PP S + + SD + S A GF++ Y +L
Sbjct: 118 YLSLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVS--AHGFKVYY--EEL 173
Query: 162 GQASC 166
+SC
Sbjct: 174 QSSSC 178
Score = 52.4 bits (124), Expect = 2e-06
Identities = 43/150 (28%), Positives = 65/150 (43%), Gaps = 25/150 (16%)
Query: 27 IFLTGRL--SSAVPALAA-CSGKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDM 83
I + G++ S +P A C G + GVI SP WP Y NC W I+ + G
Sbjct: 772 ILMDGKVMWSGLIPKCGAPCGGHFSAPS---GVILSPGWPGYYKDSLNCEWVIEAEPGHS 828
Query: 84 ITISFR------NFDVEESHQCSLDWLLLGP-AAPPRQEAFRLCGSAIPPAFISARDHVW 136
I I+F N+DV E H GP P ++ G+ +P S+ + ++
Sbjct: 829 IKITFERFQTELNYDVLEVHD--------GPNLLSPLLGSYN--GTQVPQFLFSSSNFIY 878
Query: 137 IFFHSDASSSGQAQGFRLSYIRGKLGQASC 166
+ F +D S S GF++ Y + SC
Sbjct: 879 LLFTTDNSRSN--NGFKIHYESVTVNTYSC 906
Score = 50.1 bits (118), Expect = 8e-06
Identities = 36/119 (30%), Positives = 54/119 (45%), Gaps = 12/119 (10%)
Query: 41 AACSGKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCS 100
A C G + + G I SP +P YP NC+W + G + +F F +E+ H
Sbjct: 961 ALCGGDVRGPS---GTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHH--- 1014
Query: 101 LDWLLLGPAAPPRQEAFRLCGSAIPP---AFISARDHVWIFFHSDASSSGQAQGFRLSY 156
D+LL+ Q RL GS +PP A + + F SD S S +GF +++
Sbjct: 1015 -DYLLITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSIS--YEGFNITF 1070
Score = 47.0 bits (110), Expect = 7e-05
Identities = 86/369 (23%), Positives = 136/369 (36%), Gaps = 79/369 (21%)
Query: 51 TERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSL------DWL 104
T G++ SP +PLNY C + IQ G I IS R F + + +
Sbjct: 1142 TNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKDKTTH 1201
Query: 105 LLGPAAPPRQEAFRLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYIRGKLGQA 164
LLG L S + +W+ F+SD + G +GF+L Y +L
Sbjct: 1202 LLGAFTGASMRGLTLS---------STSNQLWLEFNSD--TEGTDEGFQLVYTSFELS-- 1248
Query: 165 SCQADEFRCDNGKCLPGPWQCNTVDECG-DGSDEGNCSAPASEPPGSLCPGGTFPCSGAR 223
C++ PG + + G SD+G+ + S PG T G+
Sbjct: 1249 -------HCED----PG------IPQFGYKISDQGHFA--GSTIIYGCNPGYTL--HGSS 1287
Query: 224 STRCLPVERRC------DGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARGP 277
+C+ ERR + +CG GR G G SP
Sbjct: 1288 LLKCMTGERRAWDYPLPSCIAECG-------------GRFKGESSGRILSPGY--PFPYD 1332
Query: 278 SDLHCTWLVDTQDSRRVLLQLELRLGYD-----DYVQVYEGLGERGDRLLQTLSYRSNHR 332
++L C W+++ V LQ L +D D ++V++G E D LL+ +S +
Sbjct: 1333 NNLRCMWMIEVDPGNIVSLQF---LAFDTEASHDILRVWDGPPE-NDMLLKEIS--GSLI 1386
Query: 333 PVSLEAAQGRLTVAYHARARSAGHGFNATY--QVKGYCLPWEQPCGSSSDSDGGSLGDQG 390
P + + +T+ + + GF + V C P + + DG GD
Sbjct: 1387 PEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPMNGTRNGDGREPGDTV 1446
Query: 391 CFSEPQRCD 399
F +CD
Sbjct: 1447 VF----QCD 1451
Score = 45.4 bits (106), Expect = 2e-04
Identities = 74/320 (23%), Positives = 117/320 (36%), Gaps = 52/320 (16%)
Query: 55 GVIYSPAWPLNYPPGTNCSWYIQG-DRGDMITISFRNFDVEESHQCSLDWLLLGPAAP-- 111
G SP +P Y C W I + +I I+F FD+E + D L +G
Sbjct: 453 GTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGY----DTLTIGDGGEVG 508
Query: 112 -PRQEAFRLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYIRGKLGQASCQADE 170
PR L GS +P +S +W+ +D S + GF+++Y ++ + SC
Sbjct: 509 DPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVG--SVGFKVNY--KEIEKESCG--- 561
Query: 171 FRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARSTRCLPV 230
D G L G +G N E C G F G +S C
Sbjct: 562 ---DPGTPLYG---------IREGDGFSNRDVLRFE-----CQFG-FELIGEKSIVC--- 600
Query: 231 ERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARGPSDLHCTWLVDTQD 290
Q+ S C + G+ SPD + G ++L+C W + +
Sbjct: 601 -------QENNQWSANIPICIFPCLSNFTAPMGTVLSPD-YPEGYG-NNLNCIWTIISDP 651
Query: 291 SRRVLL---QLELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQGRLTVAY 347
R+ L +L + D++ V +G L ++ P L + L + +
Sbjct: 652 GSRIHLSFNDFDLESQF-DFLAVKDGDSPESPIL---GTFTGAEVPSHLTSNSHILRLEF 707
Query: 348 HARARSAGHGFNATYQVKGY 367
A +G GFN TY G+
Sbjct: 708 QADHSMSGRGFNITYNTFGH 727
Score = 45.4 bits (106), Expect = 2e-04
Identities = 36/116 (31%), Positives = 51/116 (43%), Gaps = 9/116 (7%)
Query: 41 AACSGKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCS 100
A C G + T G IYSP +P YP +C W ++ G+ I I+F E +
Sbjct: 2177 ALCGGNI---TAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFI 2233
Query: 101 LDWLLLGPAAPPRQEAFRLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSY 156
W GP Q + G+ + S + + I FHSD ++SG F LSY
Sbjct: 2234 TVW--DGPDQNSPQIG-QFSGNTALESVYSTSNQILIKFHSDFTTSG---FFVLSY 2283
Score = 37.4 bits (85), Expect = 0.053
Identities = 30/126 (23%), Positives = 46/126 (36%), Gaps = 4/126 (3%)
Query: 32 RLSSAVPALAACSGKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNF 91
++ A P E + GVI SP +P +YP C+W I ++G IT+ F
Sbjct: 2340 QMDGAPPVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFF 2399
Query: 92 DVEESHQCSLDWLLLGPAAPPRQEAFRLCGSAIPPAFISARDHVWIFFHSDASSSGQAQG 151
E+ D L + + AF + +F A +G
Sbjct: 2400 QTEK----EFDVLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKG 2455
Query: 152 FRLSYI 157
FR+ YI
Sbjct: 2456 FRIRYI 2461
Score = 30.4 bits (67), Expect = 6.5
Identities = 25/114 (21%), Positives = 49/114 (42%), Gaps = 11/114 (9%)
Query: 254 CGRRLGSFYGSFASPDLFGAARG-PSDLHCTWLVDTQDSRRVLLQLE---LRLGYDDYVQ 309
CG L G+ SP G G P+ +CTW++ ++ R+ + + L Y DY+
Sbjct: 65 CGGTLKGLNGTIESP---GFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEY-DYLS 120
Query: 310 VYEGLGERGDRLLQTLSYRSNHRPVSLEAAQGRLTVAYHARARSAGHGFNATYQ 363
+Y+G + + + H P + + + ++ + + HGF Y+
Sbjct: 121 LYDGHPHPTNFRTRLTGF---HLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYE 171
>gi|6912724 tolloid-like 2 [Homo sapiens]
Length = 1015
Score = 73.6 bits (179), Expect = 7e-13
Identities = 82/332 (24%), Positives = 130/332 (39%), Gaps = 70/332 (21%)
Query: 42 ACSGKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSL 101
AC G + T+ G I SP WP YP NC W + I++ F F++E + C
Sbjct: 619 ACGGFI---TKLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKY 675
Query: 102 DWLLLGPAAPPRQEAF-RLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYIRGK 160
D++ + P + R CGS P S +++ + F SD + S +GFR + K
Sbjct: 676 DFVEVRSGLSPDAKLHGRFCGSETPEVITSQSNNMRVEFKSDNTVS--KRGFRAHFFSDK 733
Query: 161 LGQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCS 220
DE DNG C EC + TF
Sbjct: 734 --------DECAKDNGGC---------QHECVN----------------------TF--- 751
Query: 221 GARSTRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARGPSDL 280
G+ RC R L + G EAG C ++ S G+ ASP+ + PS
Sbjct: 752 GSYLCRC----RNGYWLHENGHDCKEAG-----CAHKISSVEGTLASPN--WPDKYPSRR 800
Query: 281 HCTWLVDTQDSRRVLL---QLELRLGYD---DYVQVYEGLGERGDRLLQTLS-YRSNHRP 333
CTW + + RV L + E+ + D++++Y+G D L L + + +P
Sbjct: 801 ECTWNISSTAGHRVKLTFNEFEIEQHQECAYDHLEMYDG----PDSLAPILGRFCGSKKP 856
Query: 334 VSLEAAQGRLTVAYHARARSAGHGFNATYQVK 365
A+ + + +++ A GF A + +
Sbjct: 857 DPTVASGSSMFLRFYSDASVQRKGFQAVHSTE 888
Score = 62.4 bits (150), Expect = 2e-09
Identities = 97/413 (23%), Positives = 150/413 (36%), Gaps = 108/413 (26%)
Query: 41 AACSGKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCS 100
A C G + + G I SP +P +Y P C W I G + ++F+ F++E C+
Sbjct: 462 ATCGGDMNKDA---GQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCA 518
Query: 101 LDWLLLGPAAPPRQEAF--RLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYIR 158
D+L + P + A CG P S+ + +W+ F SD
Sbjct: 519 YDYLEVRD-GPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSD---------------- 561
Query: 159 GKLGQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFP 218
G + +A A+ F+ VDEC D G C GS +
Sbjct: 562 GSINKAGFAANFFK--------------EVDEC-SWPDHGGCEHRCVNTLGS------YK 600
Query: 219 CSGARSTRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARGPS 278
C+ CD + +D+ C ++ACG + G+ SP P+
Sbjct: 601 CA-------------CDPGYEL--AADKKMC-EVACGGFITKLNGTITSPG--WPKEYPT 642
Query: 279 DLHCTWLVDTQDSRRVLLQLEL--RLGYD----DYVQVYEGLGERGDRLLQTLSYRSNHR 332
+ +C W V R+ LQ E+ G D D+V+V GL D L + +
Sbjct: 643 NKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLSP--DAKLHG-RFCGSET 699
Query: 333 PVSLEAAQGRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCF 392
P + + + V + + + GF A + SD D + + GC
Sbjct: 700 PEVITSQSNNMRVEFKSDNTVSKRGFRAHF---------------FSDKDECAKDNGGCQ 744
Query: 393 SEPQ--------RC-DGWWHCASGRD--EQGCP----------ACP--PDQYP 422
E RC +G+W +G D E GC A P PD+YP
Sbjct: 745 HECVNTFGSYLCRCRNGYWLHENGHDCKEAGCAHKISSVEGTLASPNWPDKYP 797
Score = 60.1 bits (144), Expect = 8e-09
Identities = 37/117 (31%), Positives = 60/117 (51%), Gaps = 12/117 (10%)
Query: 41 AACSGKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCS 100
A C+ K+ + G + SP WP YP C+W I G + ++F F++E+ +C+
Sbjct: 774 AGCAHKI---SSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECA 830
Query: 101 LDWLLL--GP--AAPPRQEAFRLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFR 153
D L + GP AP R CGS P +++ +++ F+SDAS Q +GF+
Sbjct: 831 YDHLEMYDGPDSLAP---ILGRFCGSKKPDPTVASGSSMFLRFYSDASV--QRKGFQ 882
Score = 53.1 bits (126), Expect = 9e-07
Identities = 35/129 (27%), Positives = 59/129 (45%), Gaps = 12/129 (9%)
Query: 42 ACSGKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSL 101
AC L+ T G +P +P YP ++C W I G+ I ++F + D+ +S C
Sbjct: 350 ACGETLQDTT---GNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWY 406
Query: 102 DWLLLGPAAPPRQEAF-RLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYIRGK 160
D++ + + R CG IP +S +W+ F S ++ G +GF +Y
Sbjct: 407 DYVEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILG--KGFFAAY---- 460
Query: 161 LGQASCQAD 169
+A+C D
Sbjct: 461 --EATCGGD 467
Score = 50.1 bits (118), Expect = 8e-06
Identities = 40/145 (27%), Positives = 61/145 (42%), Gaps = 24/145 (16%)
Query: 249 CPDLACGRRLGSFYGSFASPDLFGAARG-PSDLHCTWLVDTQDSRRVLLQL------ELR 301
CP ACG L G+F++P G G PS HC W + +++L + R
Sbjct: 348 CP--ACGETLQDTTGNFSAP---GFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSR 402
Query: 302 LGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQGRLTVAYHARARSAGHGFNAT 361
L + DYV+V +G + L + + + P L + RL V + + + G GF A
Sbjct: 403 LCWYDYVEVRDGYWRKAPLLGR---FCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAA 459
Query: 362 YQVKGYCLPWEQPCGSSSDSDGGSL 386
Y E CG + D G +
Sbjct: 460 Y---------EATCGGDMNKDAGQI 475
Score = 49.7 bits (117), Expect = 1e-05
Identities = 38/127 (29%), Positives = 57/127 (44%), Gaps = 10/127 (7%)
Query: 43 CSGKLEQHTERRGVIYSPAW--PLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCS 100
C G+L+ + + +YS A NYP C W I + G + ++FR F+VEE C
Sbjct: 889 CGGRLKAEVQTKE-LYSHAQFGDNNYPSEARCDWVIVAEDGYGVELTFRTFEVEEEADCG 947
Query: 101 LDWLLL---GPAAPPRQEAFRLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYI 157
D++ ++ PR R CGS SA D + I F +D + + +GF Y
Sbjct: 948 YDYMEAYDGYDSSAPR--LGRFCGSGPLEEIYSAGDSLMIRFRTDDTIN--KKGFHARYT 1003
Query: 158 RGKLGQA 164
K A
Sbjct: 1004 STKFQDA 1010
>gi|222831592 transmembrane protease, serine 7 [Homo sapiens]
Length = 717
Score = 72.8 bits (177), Expect = 1e-12
Identities = 63/245 (25%), Positives = 87/245 (35%), Gaps = 42/245 (17%)
Query: 55 GVIYSPAWPLNYPPGTNCSWYIQGDRGDM-ITISFRNFDVEESHQ--CSLDWLLLGPAAP 111
G I SP +P YPP C+W Q + I + F N+ + + C W +
Sbjct: 253 GKISSPYYPSYYPPKCKCTWKFQTSLSTLGIALKFYNYSITKKSMKGCEHGWWEINE--- 309
Query: 112 PRQEAFRLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYIRGKLGQASCQADEF 171
CGS + I + SS + Y + Q C F
Sbjct: 310 -----HMYCGSYMDHQTIFRVPSPLVHIQLQCSSRLSDKPLLAEYGSYNISQP-CPVGSF 363
Query: 172 RCDNGKCLPGPWQCNTVDECGDGSDEGNCSAP-------ASEPPGSLCPGGTFPCSGARS 224
RC +G C+P +C+ V++C D SDE C +P + G L G C R
Sbjct: 364 RCSSGLCVPQAQRCDGVNDCFDESDELFCVSPQPACNTSSFRQHGPLICDGFRDCENGRD 423
Query: 225 ----TRCLPVERR----------------CDGLQDCGDGSDEAGCPDLACGRRLGSFYGS 264
T+ +P R CDG DC DGSDE GC C R + +
Sbjct: 424 EQNCTQSIPCNNRTFKCGNDICFRKQNAKCDGTVDCPDGSDEEGC---TCSRSSSALHRI 480
Query: 265 FASPD 269
D
Sbjct: 481 IGGTD 485
Score = 70.5 bits (171), Expect = 6e-12
Identities = 44/121 (36%), Positives = 55/121 (45%), Gaps = 12/121 (9%)
Query: 373 QPCGSSSDSDGGSLGDQGCFSEPQRCDGWWHCASGRDEQGCPACPPDQYPCEGGSGLCYT 432
QPC S L C + QRCDG C DE C + P C S +
Sbjct: 356 QPCPVGSFRCSSGL----CVPQAQRCDGVNDCFDESDELFCVSPQP---ACNTSSFRQHG 408
Query: 433 PADRCNNQKSCPDGADEKNC---FSCQPGTFHCGTNLCIF-ETWRCDGQEDCQDGSDEHG 488
P C+ + C +G DE+NC C TF CG ++C + +CDG DC DGSDE G
Sbjct: 409 PLI-CDGFRDCENGRDEQNCTQSIPCNNRTFKCGNDICFRKQNAKCDGTVDCPDGSDEEG 467
Query: 489 C 489
C
Sbjct: 468 C 468
Score = 54.3 bits (129), Expect = 4e-07
Identities = 30/85 (35%), Positives = 39/85 (45%), Gaps = 16/85 (18%)
Query: 416 CPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCFSCQPGTFHCGTNLCIFETWR-- 473
CP + C SGLC A RC+ C D +DE C S QP C ++R
Sbjct: 358 CPVGSFRCS--SGLCVPQAQRCDGVNDCFDESDELFCVSPQPA--------CNTSSFRQH 407
Query: 474 ----CDGQEDCQDGSDEHGCLAAVP 494
CDG DC++G DE C ++P
Sbjct: 408 GPLICDGFRDCENGRDEQNCTQSIP 432
Score = 30.8 bits (68), Expect = 5.0
Identities = 18/57 (31%), Positives = 23/57 (40%), Gaps = 1/57 (1%)
Query: 166 CQADEFRCDNGKCLPGP-WQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSG 221
C F+C N C +C+ +C DGSDE C+ S GGT G
Sbjct: 433 CNNRTFKCGNDICFRKQNAKCDGTVDCPDGSDEEGCTCSRSSSALHRIIGGTDTLEG 489
>gi|22547221 tolloid-like 1 [Homo sapiens]
Length = 1013
Score = 72.4 bits (176), Expect = 1e-12
Identities = 77/337 (22%), Positives = 130/337 (38%), Gaps = 78/337 (23%)
Query: 41 AACSGKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCS 100
AAC G L T+ G I +P WP YPP NC W + I++ F F++E + C
Sbjct: 616 AACGGLL---TKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCK 672
Query: 101 LDWLLLGPAAPPRQEAF-RLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYIRG 159
D++ + + + CG+ +P S +++ I F SD + S +GF+ +
Sbjct: 673 YDYVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVS--KKGFKAHFFSD 730
Query: 160 KLGQASCQADEFRCDNGKCLPGPWQC-NTVDECGDGSDEGNCSAPASEPPGSLCPGGTFP 218
K DE DNG C +C NT+ G++
Sbjct: 731 K--------DECSKDNGGC---QHECVNTM--------------------------GSYM 753
Query: 219 CSGARSTRCLPVERRCDGLQDCGDG----SDEAGCPDLACGRRLGSFYGSFASPDLFGAA 274
C C +G ++ C + C +++ S G SP+
Sbjct: 754 C-------------------QCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPN--WPD 792
Query: 275 RGPSDLHCTWLVDTQDSRRVLL---QLELRLGYD---DYVQVYEGLGERGDRLLQTLSYR 328
+ PS CTW + R+ L + E+ + D+++V++G E+ L +
Sbjct: 793 KYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFDGETEKSPILGRLC--- 849
Query: 329 SNHRPVSLEAAQGRLTVAYHARARSAGHGFNATYQVK 365
N P L A ++ V + + A GF AT+ +
Sbjct: 850 GNKIPDPLVATGNKMFVRFVSDASVQRKGFQATHSTE 886
Score = 61.6 bits (148), Expect = 3e-09
Identities = 38/117 (32%), Positives = 57/117 (48%), Gaps = 6/117 (5%)
Query: 43 CSGKLEQHTERRGVIYSPAW--PLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCS 100
C G+L+ ++ R +YS A NYP +C W + +RG + +SF+ F+VEE C
Sbjct: 887 CGGRLKAESKPRD-LYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCG 945
Query: 101 LDWLLLGPAAPPRQEAF-RLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSY 156
D++ L R CGS P S D V I FH+D + + +GF + Y
Sbjct: 946 YDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTIN--KKGFHIRY 1000
Score = 56.2 bits (134), Expect = 1e-07
Identities = 61/281 (21%), Positives = 99/281 (35%), Gaps = 65/281 (23%)
Query: 41 AACSGKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCS 100
A C G++ ++ G I SP +P +Y P C W I + ++F++F++E C+
Sbjct: 460 AICGGEIRKN---EGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCA 516
Query: 101 LDWLLLGPAAPPRQEAF-RLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYIRG 159
D+L + R CG P S + +W+ F SD G
Sbjct: 517 YDYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSD----------------G 560
Query: 160 KLGQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPC 219
+ +A A+ F+ + DEC D G C GS + C
Sbjct: 561 TVNKAGFAANFFKEE--------------DECAK-PDRGGCEQRCLNTLGS------YQC 599
Query: 220 SGARSTRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARGPSD 279
+ P R C+ ACG L G+ +P P +
Sbjct: 600 ACEPGYELGPDRRSCEA----------------ACGGLLTKLNGTITTPG--WPKEYPPN 641
Query: 280 LHCTWLVDTQDSRRVLLQLEL------RLGYDDYVQVYEGL 314
+C W V R+ ++ E + DYV+++ GL
Sbjct: 642 KNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGL 682
Score = 54.3 bits (129), Expect = 4e-07
Identities = 34/116 (29%), Positives = 52/116 (44%), Gaps = 6/116 (5%)
Query: 42 ACSGKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSL 101
AC L+ E G + SP +P YP T+C W + G+ I ++F D+ +S C
Sbjct: 348 ACGETLQ---ESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWY 404
Query: 102 DWLLLGPAAPPRQEAF-RLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSY 156
D++ + + R CG +P S +WI F S SS+ +GF Y
Sbjct: 405 DYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRS--SSNWVGKGFAAVY 458
Score = 42.4 bits (98), Expect = 0.002
Identities = 32/122 (26%), Positives = 53/122 (43%), Gaps = 15/122 (12%)
Query: 249 CPDLACGRRLGSFYGSFASPDLFGAARG-PSDLHCTWLVDTQDSRRVLLQL------ELR 301
CP ACG L G+ +SP G G PS HC W V +++L +
Sbjct: 346 CP--ACGETLQESNGNLSSP---GFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSS 400
Query: 302 LGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQGRLTVAYHARARSAGHGFNAT 361
L + DY++V +G + L + + + P L + R+ + + + + G GF A
Sbjct: 401 LCWYDYIEVRDGYWRKSPLLGR---FCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAV 457
Query: 362 YQ 363
Y+
Sbjct: 458 YE 459
>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
Length = 811
Score = 69.3 bits (168), Expect = 1e-11
Identities = 64/224 (28%), Positives = 97/224 (43%), Gaps = 47/224 (20%)
Query: 47 LEQHTERRGVIYSPAWPLNYPPGTNCSWYIQG---DRG-----DMITISFRNFDVEESHQ 98
L+ + +GV+ +P +P Y P T+CSW++ D G D + + +D+ +
Sbjct: 341 LDNRLDSQGVLSTPYFPSYYSPQTHCSWHLTVPSLDYGLALWFDAYALRRQKYDLPCTQG 400
Query: 99 CSLDWLLLGPAAPPRQEAFRLCGSAIPPAF-----ISARDHVWIFFHSDASSSGQAQGFR 153
W + + RLCG I + + A + I F S S +G G R
Sbjct: 401 ---QWTI---------QNRRLCGLRILQPYAERIPVVATAGITINFTSQISLTGP--GVR 446
Query: 154 LSYIRGKLGQASCQADEFRCD-NGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLC 212
+ Y G Q+ EF C NG C+P C+ V +C +G DE NC A
Sbjct: 447 VHY--GLYNQSDPCPGEFLCSVNGLCVPA---CDGVKDCPNGLDERNCVCRA-------- 493
Query: 213 PGGTFPCSGARSTRCLPVERRCDGLQDCGDGSDEAGCPD-LACG 255
TF C + C+ + + CDG DC +GSDE C + + CG
Sbjct: 494 ---TFQCK--EDSTCISLPKVCDGQPDCLNGSDEEQCQEGVPCG 532
Score = 61.2 bits (147), Expect = 3e-09
Identities = 35/96 (36%), Positives = 49/96 (51%), Gaps = 7/96 (7%)
Query: 398 CDGWWHCASGRDEQGCPACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNC---FS 454
CDG C +G DE+ C C + C+ S C + C+ Q C +G+DE+ C
Sbjct: 474 CDGVKDCPNGLDERNC-VCRAT-FQCKEDS-TCISLPKVCDGQPDCLNGSDEEQCQEGVP 530
Query: 455 CQPGTFHCGTNLCIFE-TWRCDGQEDCQDGSDEHGC 489
C TF C C+ + +CDG+ DC+DGSDE C
Sbjct: 531 CGTFTFQCEDRSCVKKPNPQCDGRPDCRDGSDEEHC 566
Score = 57.8 bits (138), Expect = 4e-08
Identities = 36/79 (45%), Positives = 43/79 (54%), Gaps = 11/79 (13%)
Query: 422 PCEGG-----SGLCYTPADRCNNQKSCPDGADEKNCFSCQPGTFHCGTN-LCIFETWRCD 475
PC G +GLC PA C+ K CP+G DE+NC C+ TF C + CI CD
Sbjct: 457 PCPGEFLCSVNGLC-VPA--CDGVKDCPNGLDERNCV-CR-ATFQCKEDSTCISLPKVCD 511
Query: 476 GQEDCQDGSDEHGCLAAVP 494
GQ DC +GSDE C VP
Sbjct: 512 GQPDCLNGSDEEQCQEGVP 530
Score = 47.0 bits (110), Expect = 7e-05
Identities = 24/68 (35%), Positives = 34/68 (50%), Gaps = 4/68 (5%)
Query: 388 DQGCFSEPQRCDGWWHCASGRDEQGCP---ACPPDQYPCEGGSGLCYTPADRCNNQKSCP 444
D C S P+ CDG C +G DE+ C C + CE S P +C+ + C
Sbjct: 500 DSTCISLPKVCDGQPDCLNGSDEEQCQEGVPCGTFTFQCEDRS-CVKKPNPQCDGRPDCR 558
Query: 445 DGADEKNC 452
DG+DE++C
Sbjct: 559 DGSDEEHC 566
Score = 35.0 bits (79), Expect = 0.26
Identities = 20/58 (34%), Positives = 28/58 (48%), Gaps = 4/58 (6%)
Query: 166 CQADEFRCDNGKCL--PGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSG 221
C F+C++ C+ P P QC+ +C DGSDE +C + P S GG G
Sbjct: 531 CGTFTFQCEDRSCVKKPNP-QCDGRPDCRDGSDEEHCDC-GLQGPSSRIVGGAVSSEG 586
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.453
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,196,053
Number of Sequences: 37866
Number of extensions: 2387306
Number of successful extensions: 17866
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 183
Number of HSP's successfully gapped in prelim test: 883
Number of HSP's that attempted gapping in prelim test: 10816
Number of HSP's gapped (non-prelim): 5794
length of query: 770
length of database: 18,247,518
effective HSP length: 110
effective length of query: 660
effective length of database: 14,082,258
effective search space: 9294290280
effective search space used: 9294290280
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.