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Search of human proteins with 167466231
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|167466231 cytochrome P450, family 27, subfamily C,
polypeptide 1 [Homo sapiens]
(372 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|167466231 cytochrome P450, family 27, subfamily C, polypeptid... 748 0.0
gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide ... 299 3e-81
gi|4503211 cytochrome P450, family 27, subfamily A, polypeptide ... 290 1e-78
gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1 ... 209 2e-54
gi|119829183 cytochrome P450, family 11, subfamily B, polypeptid... 175 5e-44
gi|153218646 cytochrome P450, family 11, subfamily A, polypeptid... 170 2e-42
gi|61743918 cytochrome P450, family 11, subfamily B, polypeptide... 166 4e-41
gi|153218654 cytochrome P450, family 11, subfamily A, polypeptid... 164 9e-41
gi|193083117 cytochrome P450 family 24 subfamily A polypeptide 1... 145 7e-35
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5... 130 1e-30
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ... 123 2e-28
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ... 121 9e-28
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7... 121 1e-27
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ... 121 1e-27
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide... 117 1e-26
gi|71067343 cytochrome P450, family 11, subfamily B, polypeptide... 110 2e-24
gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide ... 106 4e-23
gi|4503195 cytochrome P450, family 17 [Homo sapiens] 104 1e-22
gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18... 99 8e-21
gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18 ... 99 8e-21
gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide ... 99 8e-21
gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide ... 99 8e-21
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ... 98 1e-20
gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 1... 95 1e-19
gi|190570174 cytochrome P450, family 21, subfamily A, polypeptid... 95 1e-19
gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide... 95 1e-19
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ... 95 1e-19
gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [H... 94 2e-19
gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [H... 94 2e-19
gi|5729796 cytochrome P450, family 46 [Homo sapiens] 94 2e-19
>gi|167466231 cytochrome P450, family 27, subfamily C, polypeptide 1
[Homo sapiens]
Length = 372
Score = 748 bits (1931), Expect = 0.0
Identities = 372/372 (100%), Positives = 372/372 (100%)
Query: 1 MRSVLRQRILKPKDVAIYSGEVNQVIADLIKRIYLLRSQAEDGETVTNVNDLFFKYSMEG 60
MRSVLRQRILKPKDVAIYSGEVNQVIADLIKRIYLLRSQAEDGETVTNVNDLFFKYSMEG
Sbjct: 1 MRSVLRQRILKPKDVAIYSGEVNQVIADLIKRIYLLRSQAEDGETVTNVNDLFFKYSMEG 60
Query: 61 VATILYESRLGCLENSIPQLTVEYIEALELMFSMFKTSMYAGAIPRWLRPFIPKPWREFC 120
VATILYESRLGCLENSIPQLTVEYIEALELMFSMFKTSMYAGAIPRWLRPFIPKPWREFC
Sbjct: 61 VATILYESRLGCLENSIPQLTVEYIEALELMFSMFKTSMYAGAIPRWLRPFIPKPWREFC 120
Query: 121 RSWDGLFKFSQIHVDNKLRDIQYQMDRGRRVSGGLLTYLFLSQALTLQEIYANVTEMLLA 180
RSWDGLFKFSQIHVDNKLRDIQYQMDRGRRVSGGLLTYLFLSQALTLQEIYANVTEMLLA
Sbjct: 121 RSWDGLFKFSQIHVDNKLRDIQYQMDRGRRVSGGLLTYLFLSQALTLQEIYANVTEMLLA 180
Query: 181 GVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPTAADVPKVPLVRALLKETLR 240
GVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPTAADVPKVPLVRALLKETLR
Sbjct: 181 GVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPTAADVPKVPLVRALLKETLR 240
Query: 241 LFPVLPGNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENFPRAKEFRPERWLRKGDL 300
LFPVLPGNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENFPRAKEFRPERWLRKGDL
Sbjct: 241 LFPVLPGNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENFPRAKEFRPERWLRKGDL 300
Query: 301 DRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKTSSQTNAVHAKTHGLLTP 360
DRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKTSSQTNAVHAKTHGLLTP
Sbjct: 301 DRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKTSSQTNAVHAKTHGLLTP 360
Query: 361 GGPIHVRFVNRK 372
GGPIHVRFVNRK
Sbjct: 361 GGPIHVRFVNRK 372
>gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide 1
[Homo sapiens]
Length = 508
Score = 299 bits (765), Expect = 3e-81
Identities = 159/379 (41%), Positives = 230/379 (60%), Gaps = 15/379 (3%)
Query: 1 MRSVLRQRILKPKDVAIYSGEVNQVIADLIKRIYLLRSQAEDGET-VTNVNDLFFKYSME 59
+RS+L +L+P+ A Y+G +N V+ DL++R+ R + V +V F+K+ +E
Sbjct: 137 LRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLE 196
Query: 60 GVATILYESRLGCLENSIPQLTVEYIEALELMFSMFKTSMYAGAIPRWLRPFIPKPWREF 119
G+A +L SRLGCLE +P T +I A+ S+F +++ A+P WLR +P PW
Sbjct: 197 GIAAVLLGSRLGCLEAQVPPDTETFIRAVG---SVFVSTLLTMAMPHWLRHLVPGPWGRL 253
Query: 120 CRSWDGLFKFSQIHVDNKLRDIQYQMDRGRRV-----SGGLLTYLFLSQALTLQEIYANV 174
CR WD +F F+Q HV+ R+ + M G + SG LT+ + L Q I NV
Sbjct: 254 CRDWDQMFAFAQRHVER--REAEAAMRNGGQPEKDLESGAHLTHFLFREELPAQSILGNV 311
Query: 175 TEMLLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNL--GERHVPTAADVPKVPLVR 232
TE+LLAGVDT S TLSW +Y L+RHPEVQ ++ EI L G P+A + ++PL++
Sbjct: 312 TELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLK 371
Query: 233 ALLKETLRLFPVLPGNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENFPRAKEFRPE 292
A++KE LRL+PV+PGN RV +D+ +G Y+IPK T + LCHYATS FP FRP
Sbjct: 372 AVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPA 431
Query: 293 RWLRKGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKTSSQTNAVHA 352
RWL +G F S+PFG G RSC+GRR+AELE+ + + Q+L HFE++ V
Sbjct: 432 RWLGEGPTPH--PFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPGAAPVRP 489
Query: 353 KTHGLLTPGGPIHVRFVNR 371
KT +L P I+++F++R
Sbjct: 490 KTRTVLVPERSINLQFLDR 508
>gi|4503211 cytochrome P450, family 27, subfamily A, polypeptide 1
precursor [Homo sapiens]
Length = 531
Score = 290 bits (743), Expect = 1e-78
Identities = 143/379 (37%), Positives = 241/379 (63%), Gaps = 12/379 (3%)
Query: 1 MRSVLRQRILKPKDVAIYSGEVNQVIADLIKRIYLLRSQAEDGETVTNVNDLFFKYSMEG 60
+R L QR+LKP + A+Y+ N+VI D + R+ LR+++ G V+++ LF+ +++E
Sbjct: 157 LRQALNQRLLKPAEAALYTDAFNEVIDDFMTRLDQLRAESASGNQVSDMAQLFYYFALEA 216
Query: 61 VATILYESRLGCLENSIPQLTVEYIEALELMFSMFKTSMYAGAIPRWLRPFIPKPWREFC 120
+ IL+E R+GCL+ SIP+ TV ++ ++ LMF + S+YA +P+W RP +P W+ +
Sbjct: 217 ICYILFEKRIGCLQRSIPEDTVTFVRSIGLMF---QNSLYATFLPKWTRPVLPF-WKRYL 272
Query: 121 RSWDGLFKFSQIHVDNKLRDIQYQMDR----GRRVSGGLLTYLFLSQALTLQEIYANVTE 176
W+ +F F + +D KL D++ Q+ G +VSG L +L S L+ +E ++ E
Sbjct: 273 DGWNAIFSFGKKLIDEKLEDMEAQLQAAGPDGIQVSG-YLHFLLASGQLSPREAMGSLPE 331
Query: 177 MLLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPTAADVPKVPLVRALLK 236
+L+AGVDTTS TL+W +Y L++ PE+Q+ ++ E+V + VP D +PL++A+LK
Sbjct: 332 LLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFAHMPLLKAVLK 391
Query: 237 ETLRLFPVLPGNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENFPRAKEFRPERWLR 296
ETLRL+PV+P N R+ ++++ + G+L PK TQ CHY S F + F+P RWLR
Sbjct: 392 ETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLR 451
Query: 297 KGD--LDRVDN-FGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKTSSQTNAVHAK 353
R+ + FGS+PFG+GVR+C+GRRIAELE+ L++ +L+Q +++ + +T + +
Sbjct: 452 NSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPETGELKSV 511
Query: 354 THGLLTPGGPIHVRFVNRK 372
+L P + ++F+ R+
Sbjct: 512 ARIVLVPNKKVGLQFLQRQ 530
>gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1
isoform 1 precursor [Homo sapiens]
Length = 514
Score = 209 bits (533), Expect = 2e-54
Identities = 124/374 (33%), Positives = 203/374 (54%), Gaps = 20/374 (5%)
Query: 1 MRSVLRQRILKPKDVAIYSGEVNQVIADLIKRIYLL---RSQAEDGETVTNVNDLFFKYS 57
+RS +++++KP +V ++N+V+AD + RI L R ED + N K+S
Sbjct: 158 VRSAFQKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERGHVEDLYSELN------KWS 211
Query: 58 MEGVATILYESRLGCLENSIPQLTVEYIEALELMFSMFKTSMYAGAIPRWLRPFIPKPWR 117
E + +LYE R G L+ + V +I A++ M S F M + K W+
Sbjct: 212 FESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPV--ELHKSLNTKVWQ 269
Query: 118 EFCRSWDGLFKFSQIHVDNKLRDIQYQMDRGRRVSGGLLTYLFLSQALTLQEIYANVTEM 177
+ +WD +FK + +DN+L Q S L ++ L+ +E+YA VTE+
Sbjct: 270 DHTLAWDTIFKSVKACIDNRLEKYSQQP------SADFLCDIYHQNRLSKKELYAAVTEL 323
Query: 178 LLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPTAADVPKVPLVRALLKE 237
LA V+TT+ +L W +Y L+R+P+VQQ + +EI L E VP A D+ +P ++A LKE
Sbjct: 324 QLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKE 383
Query: 238 TLRLFPVLPGNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENFPRAKEFRPERWLRK 297
++RL P +P R + V+G Y +PKGT L L ++NF + +FRPERWL+
Sbjct: 384 SMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQ- 442
Query: 298 GDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKTSSQTNAVHAKTHGL 357
+ ++++ F +PFG G R CIGRR+AEL++HL + +++ ++I+ ++ V G
Sbjct: 443 -EKEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQ-ATDNEPVEMLHSGT 500
Query: 358 LTPGGPIHVRFVNR 371
L P + + F R
Sbjct: 501 LVPSRELPIAFCQR 514
>gi|119829183 cytochrome P450, family 11, subfamily B, polypeptide 2
precursor [Homo sapiens]
Length = 503
Score = 175 bits (444), Expect = 5e-44
Identities = 116/344 (33%), Positives = 183/344 (53%), Gaps = 11/344 (3%)
Query: 5 LRQRILKPKDVAIYSGEVNQVIADLIKRIYLLRSQAEDGETVTNVNDLFFKYSMEGVATI 64
L +L PK V + V+ V D + + Q G +V F Y++E
Sbjct: 144 LNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA 203
Query: 65 LYESRLGCLENSIPQLTVEYIEALELMFSMFKTSMYAGAIPRWLRPFI-PKPWREFCRSW 123
L+ RLG + +S ++ ++ ALE+MF K+++ +PR L +I PK W+E +W
Sbjct: 204 LFGERLGLVGHSPSSASLNFLHALEVMF---KSTVQLMFMPRSLSRWISPKVWKEHFEAW 260
Query: 124 DGLFKFSQIHVDNKLRDIQYQMDRGR-RVSGGLLTYLFLSQALTLQEIYANVTEMLLAGV 182
D +F++ DN ++ I ++ R + G++ L L L+L+ I AN E+ V
Sbjct: 261 DCIFQYG----DNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSV 316
Query: 183 DTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPTAADVPKVPLVRALLKETLRLF 242
DTT+F L T++ LAR+P+VQQ + +E + ++PL+RA LKETLRL+
Sbjct: 317 DTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLY 376
Query: 243 PVLPGNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENFPRAKEFRPERWLRKGDLDR 302
PV RV DLV+ Y IP GT + + Y+ FPR + + P+RWL R
Sbjct: 377 PVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGR 436
Query: 303 VDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKTSSQ 346
NF +PFG G+R C+GRR+AE E+ L++ +L+HF ++T +Q
Sbjct: 437 --NFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQ 478
>gi|153218646 cytochrome P450, family 11, subfamily A, polypeptide 1
isoform a precursor [Homo sapiens]
Length = 521
Score = 170 bits (430), Expect = 2e-42
Identities = 112/368 (30%), Positives = 188/368 (51%), Gaps = 8/368 (2%)
Query: 2 RSVLRQRILKPKDVAIYSGEVNQVIADLIKRIYLLRSQAEDGETVTNVNDLFFKYSMEGV 61
R L Q ++ P+ + ++ V D + ++ +A G +++D F+++ E +
Sbjct: 151 RVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESI 210
Query: 62 ATILYESRLGCLENSIPQLTVEYIEALELMFSMFKTSMYAGAIPRWL-RPFIPKPWREFC 120
+++ R G LE + +I+A+ + MF TS+ +P L R F K W++
Sbjct: 211 TNVIFGERQGMLEEVVNPEAQRFIDAI---YQMFHTSVPMLNLPPDLFRLFRTKTWKDHV 267
Query: 121 RSWDGLFKFSQIHVDNKLRDIQYQMDRGRRVSGGLLTYLFLSQALTLQEIYANVTEMLLA 180
+WD +F + I+ N +++ Q G+L L ++ ++I ANVTEML
Sbjct: 268 AAWDVIFSKADIYTQNFYWELR-QKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAG 326
Query: 181 GVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPTAADVPKVPLVRALLKETLR 240
GVDTTS TL W +Y +AR+ +VQ + E++ + A + VPL++A +KETLR
Sbjct: 327 GVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLR 386
Query: 241 LFPVLPGNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENFPRAKEFRPERWLRKGDL 300
L P+ R DLV+ Y+IP T + + YA + F + F P RWL K
Sbjct: 387 LHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKD-- 444
Query: 301 DRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKTSSQTNAVHAKTHGLLTP 360
+ F ++ FG GVR C+GRRIAELE+ + +I +L++F ++ ++ V + +L P
Sbjct: 445 KNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSD-VGTTFNLILMP 503
Query: 361 GGPIHVRF 368
PI F
Sbjct: 504 EKPISFTF 511
>gi|61743918 cytochrome P450, family 11, subfamily B, polypeptide 1
isoform 1 precursor [Homo sapiens]
Length = 503
Score = 166 bits (419), Expect = 4e-41
Identities = 110/344 (31%), Positives = 174/344 (50%), Gaps = 11/344 (3%)
Query: 5 LRQRILKPKDVAIYSGEVNQVIADLIKRIYLLRSQAEDGETVTNVNDLFFKYSMEGVATI 64
L +L P V + V+ V D + + Q G +V F Y++E
Sbjct: 144 LNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA 203
Query: 65 LYESRLGCLENSIPQLTVEYIEALELMFSMFKTSMYAG-AIPRWLRPFIPKPWREFCRSW 123
L+ RLG + +S ++ ++ ALE+MF M+ ++ RW P K W+E +W
Sbjct: 204 LFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSP---KVWKEHFEAW 260
Query: 124 DGLFKFSQIHVDNKLRDIQYQMDRGR-RVSGGLLTYLFLSQALTLQEIYANVTEMLLAGV 182
D +F++ DN ++ I ++ R + ++ L L+ L+ I AN E+ V
Sbjct: 261 DCIFQYG----DNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSV 316
Query: 183 DTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPTAADVPKVPLVRALLKETLRLF 242
DTT F L T++ LAR+P VQQ + +E + ++PL+RA LKETLRL+
Sbjct: 317 DTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLY 376
Query: 243 PVLPGNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENFPRAKEFRPERWLRKGDLDR 302
PV RV DLV+ Y IP GT + + Y+ FPR + + P+RWL R
Sbjct: 377 PVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGR 436
Query: 303 VDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKTSSQ 346
NF +PFG G+R C+GRR+AE E+ L++ +L+H +++T +Q
Sbjct: 437 --NFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQ 478
>gi|153218654 cytochrome P450, family 11, subfamily A, polypeptide 1
isoform b [Homo sapiens]
Length = 363
Score = 164 bits (416), Expect = 9e-41
Identities = 108/348 (31%), Positives = 180/348 (51%), Gaps = 8/348 (2%)
Query: 22 VNQVIADLIKRIYLLRSQAEDGETVTNVNDLFFKYSMEGVATILYESRLGCLENSIPQLT 81
++ V D + ++ +A G +++D F+++ E + +++ R G LE +
Sbjct: 13 LDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEA 72
Query: 82 VEYIEALELMFSMFKTSMYAGAIPRWL-RPFIPKPWREFCRSWDGLFKFSQIHVDNKLRD 140
+I+A+ + MF TS+ +P L R F K W++ +WD +F + I+ N +
Sbjct: 73 QRFIDAI---YQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWE 129
Query: 141 IQYQMDRGRRVSGGLLTYLFLSQALTLQEIYANVTEMLLAGVDTTSFTLSWTVYLLARHP 200
++ Q G+L L ++ ++I ANVTEML GVDTTS TL W +Y +AR+
Sbjct: 130 LR-QKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNL 188
Query: 201 EVQQTVYREIVKNLGERHVPTAADVPKVPLVRALLKETLRLFPVLPGNGRVTQEDLVIGG 260
+VQ + E++ + A + VPL++A +KETLRL P+ R DLV+
Sbjct: 189 KVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRD 248
Query: 261 YLIPKGTQLALCHYATSYQDENFPRAKEFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIG 320
Y+IP T + + YA + F + F P RWL K + F ++ FG GVR C+G
Sbjct: 249 YMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKD--KNITYFRNLGFGWGVRQCLG 306
Query: 321 RRIAELEIHLVVIQLLQHFEIKTSSQTNAVHAKTHGLLTPGGPIHVRF 368
RRIAELE+ + +I +L++F ++ ++ V + +L P PI F
Sbjct: 307 RRIAELEMTIFLINMLENFRVEIQHLSD-VGTTFNLILMPEKPISFTF 353
>gi|193083117 cytochrome P450 family 24 subfamily A polypeptide 1
isoform 2 precursor [Homo sapiens]
Length = 448
Score = 145 bits (365), Expect = 7e-35
Identities = 89/269 (33%), Positives = 143/269 (53%), Gaps = 17/269 (6%)
Query: 1 MRSVLRQRILKPKDVAIYSGEVNQVIADLIKRIYLL---RSQAEDGETVTNVNDLFFKYS 57
+RS +++++KP +V ++N+V+AD + RI L R ED + N K+S
Sbjct: 158 VRSAFQKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERGHVEDLYSELN------KWS 211
Query: 58 MEGVATILYESRLGCLENSIPQLTVEYIEALELMFSMFKTSMYAGAIPRWLRPFIPKPWR 117
E + +LYE R G L+ + V +I A++ M S F M + K W+
Sbjct: 212 FESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPV--ELHKSLNTKVWQ 269
Query: 118 EFCRSWDGLFKFSQIHVDNKLRDIQYQMDRGRRVSGGLLTYLFLSQALTLQEIYANVTEM 177
+ +WD +FK + +DN+L Q S L ++ L+ +E+YA VTE+
Sbjct: 270 DHTLAWDTIFKSVKACIDNRLEKYSQQP------SADFLCDIYHQNRLSKKELYAAVTEL 323
Query: 178 LLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPTAADVPKVPLVRALLKE 237
LA V+TT+ +L W +Y L+R+P+VQQ + +EI L E VP A D+ +P ++A LKE
Sbjct: 324 QLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKE 383
Query: 238 TLRLFPVLPGNGRVTQEDLVIGGYLIPKG 266
++RL P +P R + V+G Y +PKG
Sbjct: 384 SMRLTPSVPFTTRTLDKATVLGEYALPKG 412
>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
[Homo sapiens]
Length = 502
Score = 130 bits (328), Expect = 1e-30
Identities = 108/347 (31%), Positives = 172/347 (49%), Gaps = 22/347 (6%)
Query: 36 LRSQAEDGETVTNVNDLFFKYSMEGVATILYESRLGCLENSIPQLTVEYIEALE--LMFS 93
LR +AE G+ VT + D+F YSM+ + + + L N PQ ++E+ + L F
Sbjct: 160 LRREAEKGKPVT-LKDIFGAYSMDVITGTSFGVNIDSLNN--PQ--DPFVESTKKFLKFG 214
Query: 94 MFKTSMYAGAIPRWLRP--------FIPKPWREFCRSWDGLFKFSQIHVDNKLRDIQYQM 145
+ + +L P PK F K S+++ K R Q+
Sbjct: 215 FLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQL 274
Query: 146 DRGRRVSGGLLTYLFLSQALTLQEIYANVTEMLLAGVDTTSFTLSWTVYLLARHPEVQQT 205
+ S ++ +AL+ E+ A + AG +TTS LS+T+Y LA HP+VQQ
Sbjct: 275 MIDSQNSKETESH----KALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQK 330
Query: 206 VYREIVKNLGERHVPTAADVPKVPLVRALLKETLRLFPVLPGNGRVTQEDLVIGGYLIPK 265
+ +EI L + PT V ++ + ++ ETLRLFPV R ++D+ I G IPK
Sbjct: 331 LQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPK 390
Query: 266 GTQLALCHYATSYQDENFPRAKEFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIGRRIAE 325
G+ + + YA + + + +EFRPER+ +K D +D + PFG G R+CIG R A
Sbjct: 391 GSMVVIPTYALHHDPKYWTEPEEFRPERFSKK--KDSIDPYIYTPFGTGPRNCIGMRFAL 448
Query: 326 LEIHLVVIQLLQHFEIKTSSQTN-AVHAKTHGLLTPGGPIHVRFVNR 371
+ + L +I++LQ+F K +T + T GLL P PI ++ +R
Sbjct: 449 MNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSR 495
>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
[Homo sapiens]
Length = 503
Score = 123 bits (309), Expect = 2e-28
Identities = 103/345 (29%), Positives = 167/345 (48%), Gaps = 17/345 (4%)
Query: 36 LRSQAEDGETVTNVNDLFFKYSMEGVATILYESRLGCLENSIPQLTVEYIEALELMFSMF 95
LR +AE G+ VT + D+F YSM+ + + + + L N VE + L L F
Sbjct: 160 LRREAETGKPVT-LKDVFGAYSMDVITSTSFGVNIDSLNNPQDPF-VENTKKL-LRFDFL 216
Query: 96 KTSMYAGAIPRWLRPFI--------PKPWREFCRSWDGLFKFSQIHVDNKLRDIQYQMDR 147
+ + +L P + P+ F R K S++ K R Q+
Sbjct: 217 DPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMI 276
Query: 148 GRRVSGGLLTYLFLSQALTLQEIYANVTEMLLAGVDTTSFTLSWTVYLLARHPEVQQTVY 207
+ S ++ +AL+ E+ A + AG +TTS LS+ +Y LA HP+VQQ +
Sbjct: 277 DSQNSKETESH----KALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQ 332
Query: 208 REIVKNLGERHVPTAADVPKVPLVRALLKETLRLFPVLPGNGRVTQEDLVIGGYLIPKGT 267
EI L + PT V ++ + ++ ETLRLFP+ RV ++D+ I G IPKG
Sbjct: 333 EEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGV 392
Query: 268 QLALCHYATSYQDENFPRAKEFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIGRRIAELE 327
+ + YA + + ++F PER+ +K + D +D + PFG G R+CIG R A +
Sbjct: 393 VVMIPSYALHRDPKYWTEPEKFLPERFSKK-NKDNIDPYIYTPFGSGPRNCIGMRFALMN 451
Query: 328 IHLVVIQLLQHFEIKTSSQTN-AVHAKTHGLLTPGGPIHVRFVNR 371
+ L +I++LQ+F K +T + GLL P P+ ++ +R
Sbjct: 452 MKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 496
>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 2 [Homo sapiens]
Length = 503
Score = 121 bits (304), Expect = 9e-28
Identities = 103/352 (29%), Positives = 172/352 (48%), Gaps = 25/352 (7%)
Query: 9 ILKPKDVAIYSGEVNQVIA---DLIKRIYLLRSQAEDGETVTNVNDLFFKYSMEGVATIL 65
+L P ++ E+ +I+ D++ R LR +AE+ +++ N+ D F Y+M+ + L
Sbjct: 132 LLSPAFTSVKFKEMVPIISQCGDMLVRS--LRQEAENSKSI-NLKDFFGAYTMDVITGTL 188
Query: 66 YESRLGCLENSIPQ----------LTVEYIEALELMFSMFKTSMYAGAIPRWLRPFIPKP 115
+ L L N PQ L +++++ L+ S+F PK
Sbjct: 189 FGVNLDSLNN--PQDPFLKNMKKLLKLDFLDPFLLLISLFP--FLTPVFEALNIGLFPKD 244
Query: 116 WREFCRSWDGLFKFSQIHVDNKLRDIQYQMDRGRRVSGGLLTYLFLSQALTLQEIYANVT 175
F ++ K S++ K R +Q + S ++ +AL+ E+ A
Sbjct: 245 VTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSH----KALSDLELVAQSI 300
Query: 176 EMLLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPTAADVPKVPLVRALL 235
++ A DTTS TL + +Y LA HP+VQQ + EI L + T + ++ + ++
Sbjct: 301 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV 360
Query: 236 KETLRLFPVLPGNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENFPRAKEFRPERWL 295
ETLRLFPV+ RV ++D+ I G IPKG + + YA + + + ++F PER+
Sbjct: 361 NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFS 420
Query: 296 RKGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKTSSQT 347
+K + D +D + IPFG G R+CIG R A I L VI+ LQ+F K +T
Sbjct: 421 KK-NKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKET 471
>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
[Homo sapiens]
Length = 503
Score = 121 bits (303), Expect = 1e-27
Identities = 100/351 (28%), Positives = 169/351 (48%), Gaps = 29/351 (8%)
Query: 36 LRSQAEDGETVTNVNDLFFKYSMEGVATILYESRLGCL--------ENSIPQLTVEYIEA 87
LR +AE G+ VT + +F YSM+ + + + + L EN+ L ++
Sbjct: 160 LRREAETGKPVT-LKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDP 218
Query: 88 LELMFSMFK------TSMYAGAIPRWLRPFIPKPWREFCRSWDGLFKFSQIHVDNKLRDI 141
L +F ++ PR + F+ K ++ +G K +Q H ++ +
Sbjct: 219 FVLSIKVFPFLTPILEALNITVFPRKVISFLTKSVKQIK---EGRLKETQKH---RVDFL 272
Query: 142 QYQMDRGRRVSGGLLTYLFLSQALTLQEIYANVTEMLLAGVDTTSFTLSWTVYLLARHPE 201
Q +D +AL+ E+ A + AG +TTS LS+ +Y LA HP+
Sbjct: 273 QLMIDSQNSKDSET------HKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPD 326
Query: 202 VQQTVYREIVKNLGERHVPTAADVPKVPLVRALLKETLRLFPVLPGNGRVTQEDLVIGGY 261
VQQ V +EI L + PT V ++ + ++ ETLRLFPV RV ++D+ I G
Sbjct: 327 VQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGM 386
Query: 262 LIPKGTQLALCHYATSYQDENFPRAKEFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIGR 321
IPKG + + Y + + + ++F PER+ +K + D +D + PFG G R+CIG
Sbjct: 387 FIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKK-NKDNIDPYIYTPFGSGPRNCIGM 445
Query: 322 RIAELEIHLVVIQLLQHFEIKTSSQTN-AVHAKTHGLLTPGGPIHVRFVNR 371
R A + + L ++++LQ+F K +T + + GLL PI ++ +R
Sbjct: 446 RFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEKPIVLKAESR 496
>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 1 [Homo sapiens]
Length = 504
Score = 121 bits (303), Expect = 1e-27
Identities = 102/352 (28%), Positives = 169/352 (48%), Gaps = 24/352 (6%)
Query: 9 ILKPKDVAIYSGEVNQVIA---DLIKRIYLLRSQAEDGETVTNVNDLFFKYSMEGVATIL 65
+L P ++ E+ +I+ D++ R LR +AE+ +++ N+ D F Y+M+ + L
Sbjct: 132 LLSPAFTSVKFKEMVPIISQCGDMLVRS--LRQEAENSKSI-NLKDFFGAYTMDVITGTL 188
Query: 66 YESRLGCLENSIPQ----------LTVEYIEALELMFSMFKTSMYAGAIPRWLRPFIPKP 115
+ L L N PQ L +++++ L+ S+F PK
Sbjct: 189 FGVNLDSLNN--PQDPFLKNMKKLLKLDFLDPFLLLISLFP--FLTPVFEALNIGLFPKD 244
Query: 116 WREFCRSWDGLFKFSQIHVDNKLRDIQYQMDRGRRVSGGLLTYLFLSQALTLQEIYANVT 175
F ++ K S++ K R +Q + S ++ +AL+ E+ A
Sbjct: 245 VTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSH----KALSDLELVAQSI 300
Query: 176 EMLLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPTAADVPKVPLVRALL 235
++ A DTTS TL + +Y LA HP+VQQ + EI L + T + ++ + ++
Sbjct: 301 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV 360
Query: 236 KETLRLFPVLPGNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENFPRAKEFRPERWL 295
ETLRLFPV+ RV ++D+ I G IPKG + + YA + + + ++F PE
Sbjct: 361 NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRF 420
Query: 296 RKGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKTSSQT 347
K + D +D + IPFG G R+CIG R A I L VI+ LQ+F K +T
Sbjct: 421 SKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKET 472
>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
[Homo sapiens]
Length = 525
Score = 117 bits (294), Expect = 1e-26
Identities = 66/208 (31%), Positives = 112/208 (53%), Gaps = 2/208 (0%)
Query: 165 LTLQEIYANVTEMLLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVP-TAA 223
L+ ++I V + G DTT+ ++W++YLL +PEVQ+ V E+ G+ P T
Sbjct: 314 LSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVE 373
Query: 224 DVPKVPLVRALLKETLRLFPVLPGNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENF 283
D+ K+ + ++KETLRLFP +P R ED + GY + KGT+ + YA F
Sbjct: 374 DLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYF 433
Query: 284 PRAKEFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKT 343
P +EF+PER+ + R + +PF G R+CIG++ A +E ++ +L+HF I++
Sbjct: 434 PNPEEFQPERFFPENAQGR-HPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIES 492
Query: 344 SSQTNAVHAKTHGLLTPGGPIHVRFVNR 371
+ + + + +L P I ++ R
Sbjct: 493 NQKREELGLEGQLILRPSNGIWIKLKRR 520
>gi|71067343 cytochrome P450, family 11, subfamily B, polypeptide 1
isoform 2 precursor [Homo sapiens]
Length = 437
Score = 110 bits (276), Expect = 2e-24
Identities = 81/264 (30%), Positives = 126/264 (47%), Gaps = 9/264 (3%)
Query: 5 LRQRILKPKDVAIYSGEVNQVIADLIKRIYLLRSQAEDGETVTNVNDLFFKYSMEGVATI 64
L +L P V + V+ V D + + Q G +V F Y++E
Sbjct: 144 LNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA 203
Query: 65 LYESRLGCLENSIPQLTVEYIEALELMFSMFKTSMYAG-AIPRWLRPFIPKPWREFCRSW 123
L+ RLG + +S ++ ++ ALE+MF M+ ++ RW P K W+E +W
Sbjct: 204 LFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSP---KVWKEHFEAW 260
Query: 124 DGLFKFSQIHVDNKLRDIQYQMDRGR-RVSGGLLTYLFLSQALTLQEIYANVTEMLLAGV 182
D +F++ DN ++ I ++ R + ++ L L+ L+ I AN E+ V
Sbjct: 261 DCIFQYG----DNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSV 316
Query: 183 DTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPTAADVPKVPLVRALLKETLRLF 242
DTT F L T++ LAR+P VQQ + +E + ++PL+RA LKETLRL+
Sbjct: 317 DTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLY 376
Query: 243 PVLPGNGRVTQEDLVIGGYLIPKG 266
PV RV DLV+ Y IP G
Sbjct: 377 PVGLFLERVASSDLVLQNYHIPAG 400
>gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide 1
[Homo sapiens]
Length = 493
Score = 106 bits (264), Expect = 4e-23
Identities = 54/178 (30%), Positives = 98/178 (55%), Gaps = 2/178 (1%)
Query: 166 TLQEIYANVTEMLLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPTAADV 225
T+ I V ++ AG +TTS TL + + +L ++PE+++ ++ EI + +G +P D
Sbjct: 285 TMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDR 344
Query: 226 PKVPLVRALLKETLRLFPVLPGN-GRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENFP 284
++P + A++ E R ++P N D + GYLIPKGT + + Y ++ FP
Sbjct: 345 QEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFP 404
Query: 285 RAKEFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIK 342
++F+PE +L + + ++ PF G R C G +A +E+ L++ +LQHF +K
Sbjct: 405 DPEKFKPEHFLNENGKFKYSDYFK-PFSTGKRVCAGEGLARMELFLLLCAILQHFNLK 461
>gi|4503195 cytochrome P450, family 17 [Homo sapiens]
Length = 508
Score = 104 bits (260), Expect = 1e-22
Identities = 58/183 (31%), Positives = 103/183 (56%), Gaps = 2/183 (1%)
Query: 162 SQALTLQEIYANVTEMLLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPT 221
S+ L+ I + ++ AGV+TT+ + WT+ L +P+V++ +Y EI +N+G PT
Sbjct: 284 SELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPT 343
Query: 222 AADVPKVPLVRALLKETLRLFPVLPG-NGRVTQEDLVIGGYLIPKGTQLALCHYATSYQD 280
+D ++ L+ A ++E LRL PV P D IG + + KGT++ + +A + +
Sbjct: 344 ISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNE 403
Query: 281 ENFPRAKEFRPERWLRKGDLDRVD-NFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHF 339
+ + + +F PER+L + + +PFG G RSCIG +A E+ L++ LLQ F
Sbjct: 404 KEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463
Query: 340 EIK 342
+++
Sbjct: 464 DLE 466
>gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18
isoform 2 [Homo sapiens]
Length = 431
Score = 98.6 bits (244), Expect = 8e-21
Identities = 61/180 (33%), Positives = 94/180 (52%), Gaps = 4/180 (2%)
Query: 166 TLQEIYANVTEMLLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPTAADV 225
T++ + A VT+M AG +TTS TL + + LL ++PEV V EI +G P D
Sbjct: 224 TVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDR 283
Query: 226 PKVPLVRALLKETLRLFPVLPGN-GRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENFP 284
+P A++ E R +LP N D+ YLIPKGT + + + D+ FP
Sbjct: 284 SHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFP 343
Query: 285 RAKEFRPERWLRK-GDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKT 343
+ F P +L K G+ + D F +PF G R C+G +A +E+ L + +LQ+F +K+
Sbjct: 344 NPEMFDPGHFLDKSGNFKKSDYF--MPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKS 401
>gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18
isoform 1 [Homo sapiens]
Length = 490
Score = 98.6 bits (244), Expect = 8e-21
Identities = 61/180 (33%), Positives = 94/180 (52%), Gaps = 4/180 (2%)
Query: 166 TLQEIYANVTEMLLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPTAADV 225
T++ + A VT+M AG +TTS TL + + LL ++PEV V EI +G P D
Sbjct: 283 TVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDR 342
Query: 226 PKVPLVRALLKETLRLFPVLPGN-GRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENFP 284
+P A++ E R +LP N D+ YLIPKGT + + + D+ FP
Sbjct: 343 SHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFP 402
Query: 285 RAKEFRPERWLRK-GDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKT 343
+ F P +L K G+ + D F +PF G R C+G +A +E+ L + +LQ+F +K+
Sbjct: 403 NPEMFDPGHFLDKSGNFKKSDYF--MPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKS 460
>gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide 1
[Homo sapiens]
Length = 501
Score = 98.6 bits (244), Expect = 8e-21
Identities = 57/181 (31%), Positives = 92/181 (50%), Gaps = 2/181 (1%)
Query: 162 SQALTLQEIYANVTEMLLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPT 221
S + + + +V E+++AG +TT+ L W + +A +P +Q V +EI +G P+
Sbjct: 292 SSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPS 351
Query: 222 AADVPKVPLVRALLKETLRLFPVLP-GNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQD 280
D K+P A+L E LR ++P G T ED V+ GY IPKGT + Y+ + +
Sbjct: 352 WDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDE 411
Query: 281 ENFPRAKEFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFE 340
+ + + F PER+L +PF G R C+G +A +E+ L LLQ F
Sbjct: 412 KYWRDPEVFHPERFLDSSGY-FAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFH 470
Query: 341 I 341
+
Sbjct: 471 L 471
>gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide 1
[Homo sapiens]
Length = 490
Score = 98.6 bits (244), Expect = 8e-21
Identities = 56/167 (33%), Positives = 85/167 (50%), Gaps = 3/167 (1%)
Query: 176 EMLLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPTAADVPKVPLVRALL 235
+M++AG +TTS TL W L+ RHP+VQ V E+ + LG P D +P A+L
Sbjct: 292 DMVMAGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVL 351
Query: 236 KETLRLFPVLPGNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENFPRAKEFRPERWL 295
E R +LP R T D +GG+L+PKGT + + + + +F P +L
Sbjct: 352 HEVQRFITLLPHVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFL 411
Query: 296 -RKGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEI 341
G + + F +PF G R C+G R+A E+ L+ LLQ + +
Sbjct: 412 DANGHFVKREAF--LPFSAGRRVCVGERLARTELFLLFAGLLQRYRL 456
>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
[Homo sapiens]
Length = 544
Score = 98.2 bits (243), Expect = 1e-20
Identities = 54/168 (32%), Positives = 97/168 (57%), Gaps = 4/168 (2%)
Query: 174 VTEMLLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPTAADVPKVPLVRA 233
+ ++ +AG DTT+ +L W + ++ +P+VQ+ V+ EI + +G P+ D ++P A
Sbjct: 346 IGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMPYTEA 405
Query: 234 LLKETLRLFPVLP-GNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENFPRAKEFRPE 292
+ E RL V+P +T E+ V+ GY IPKGT + ++ + + ++F P
Sbjct: 406 TIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPN 465
Query: 293 RWL-RKGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHF 339
R+L +G L + + F IPFG G R C+G ++A++E+ L+ + L+Q F
Sbjct: 466 RFLDDQGQLIKKETF--IPFGIGKRVCMGEQLAKMELFLMFVSLMQSF 511
>gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 19
[Homo sapiens]
Length = 490
Score = 94.7 bits (234), Expect = 1e-19
Identities = 54/179 (30%), Positives = 92/179 (51%), Gaps = 2/179 (1%)
Query: 166 TLQEIYANVTEMLLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPTAADV 225
T++ + ++L AG +TTS TL + + LL +HPEV V EI + +G P D
Sbjct: 283 TIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDR 342
Query: 226 PKVPLVRALLKETLRLFPVLPGN-GRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENFP 284
+P A++ E R ++P + D+ YLIPKGT + + + ++ FP
Sbjct: 343 GHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFP 402
Query: 285 RAKEFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKT 343
+ F P +L +G + N+ +PF G R C+G +A +E+ L + +LQ+F +K+
Sbjct: 403 NPEMFDPRHFLDEGGNFKKSNY-FMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKS 460
>gi|190570174 cytochrome P450, family 21, subfamily A, polypeptide 2
isoform b [Homo sapiens]
Length = 465
Score = 94.7 bits (234), Expect = 1e-19
Identities = 62/180 (34%), Positives = 92/180 (51%), Gaps = 11/180 (6%)
Query: 170 IYANVTEMLLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLG----ERHVPTAADV 225
++ ++L+ G +TT+ TLSW V L HPE+QQ + E+ LG VP D
Sbjct: 252 VHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP-YKDR 310
Query: 226 PKVPLVRALLKETLRLFPVLP-GNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENFP 284
++PL+ A + E LRL PV+P T I GY IP+GT + + +
Sbjct: 311 ARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWE 370
Query: 285 RAKEFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKTS 344
R EF P+R+L G N ++ FG G R C+G +A LE+ +V+ +LLQ F + S
Sbjct: 371 RPHEFWPDRFLEPG-----KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPS 425
>gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide 2
isoform a [Homo sapiens]
Length = 495
Score = 94.7 bits (234), Expect = 1e-19
Identities = 62/180 (34%), Positives = 92/180 (51%), Gaps = 11/180 (6%)
Query: 170 IYANVTEMLLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLG----ERHVPTAADV 225
++ ++L+ G +TT+ TLSW V L HPE+QQ + E+ LG VP D
Sbjct: 282 VHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP-YKDR 340
Query: 226 PKVPLVRALLKETLRLFPVLP-GNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENFP 284
++PL+ A + E LRL PV+P T I GY IP+GT + + +
Sbjct: 341 ARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWE 400
Query: 285 RAKEFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKTS 344
R EF P+R+L G N ++ FG G R C+G +A LE+ +V+ +LLQ F + S
Sbjct: 401 RPHEFWPDRFLEPG-----KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPS 455
>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
[Homo sapiens]
Length = 502
Score = 94.7 bits (234), Expect = 1e-19
Identities = 67/267 (25%), Positives = 116/267 (43%), Gaps = 18/267 (6%)
Query: 82 VEYIEALELMFSMFKTSMYAGAIPRWLRPFIPKPWREFCRSWDGLFKFSQIHVDNKLRDI 141
V Y+EA KT P W+ F+P P + +W L F +D +D
Sbjct: 218 VTYLEAS-------KTCQLYNVFP-WIMKFLPGPHQTLFSNWKKLKLFVSHMIDKHRKD- 268
Query: 142 QYQMDRGRRVSGGLLTYLFL-----SQALTLQEIYANVTEMLLAGVDTTSFTLSWTVYLL 196
+ R L + + + + + + ++ AG +TTS TL W + +
Sbjct: 269 -WNPAETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYM 327
Query: 197 ARHPEVQQTVYREIVKNLGERHVPTAADVPKVPLVRALLKETLRLFPVLPGN-GRVTQED 255
A +PE+Q+ V EI + +G+ P+ A +P A++ E R+ ++P N R D
Sbjct: 328 ALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVD 387
Query: 256 LVIGGYLIPKGTQLALCHYATSYQDENFPRAKEFRPERWLRKGDLDRVDNFGSIPFGHGV 315
+ GY +PKGT + A + F P+ +L G + + F +PF G
Sbjct: 388 TTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLENGQFKKREAF--MPFSIGK 445
Query: 316 RSCIGRRIAELEIHLVVIQLLQHFEIK 342
R+C+G ++A E+ + L+Q F +
Sbjct: 446 RACLGEQLARTELFIFFTSLMQKFTFR 472
>gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [Homo
sapiens]
Length = 534
Score = 94.0 bits (232), Expect = 2e-19
Identities = 59/213 (27%), Positives = 108/213 (50%), Gaps = 3/213 (1%)
Query: 161 LSQALTLQEIYANVTEMLLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVP 220
+++ LT+ EI L+AG + + TLS+ YLLA +P+ Q+ + RE+ + P
Sbjct: 323 MARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAP 382
Query: 221 TAADVPK-VPLVRALLKETLRLFPVLPGNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQ 279
+ + +P + ++ ETLR++P R +D + G IP G L + A +
Sbjct: 383 EFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHD 442
Query: 280 DENFPRAKEFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHF 339
E++P + F PER+ + + F +PFG G RSC+G R+ LE+ L ++ +L F
Sbjct: 443 PEHWPSPETFNPERFTAEA-RQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKF 501
Query: 340 EIKTSSQTNA-VHAKTHGLLTPGGPIHVRFVNR 371
+ +T + ++ L P ++++ V+R
Sbjct: 502 RFQACPETQVPLQLESKSALGPKNGVYIKIVSR 534
>gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [Homo
sapiens]
Length = 534
Score = 94.0 bits (232), Expect = 2e-19
Identities = 59/213 (27%), Positives = 108/213 (50%), Gaps = 3/213 (1%)
Query: 161 LSQALTLQEIYANVTEMLLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVP 220
+++ LT+ EI L+AG + + TLS+ YLLA +P+ Q+ + RE+ + P
Sbjct: 323 MARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAP 382
Query: 221 TAADVPK-VPLVRALLKETLRLFPVLPGNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQ 279
+ + +P + ++ ETLR++P R +D + G IP G L + A +
Sbjct: 383 EFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHD 442
Query: 280 DENFPRAKEFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHF 339
E++P + F PER+ + + F +PFG G RSC+G R+ LE+ L ++ +L F
Sbjct: 443 PEHWPSPETFNPERFTAEA-RQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKF 501
Query: 340 EIKTSSQTNA-VHAKTHGLLTPGGPIHVRFVNR 371
+ +T + ++ L P ++++ V+R
Sbjct: 502 RFQACPETQVPLQLESKSALGPKNGVYIKIVSR 534
>gi|5729796 cytochrome P450, family 46 [Homo sapiens]
Length = 500
Score = 94.0 bits (232), Expect = 2e-19
Identities = 78/312 (25%), Positives = 145/312 (46%), Gaps = 17/312 (5%)
Query: 33 IYLLRSQAEDGETVTNVNDLFFKYSMEGVATILYESRLGCLENSIPQLTVEYIEALELMF 92
+ +L ++A DG+T ++ D+ +M+ +A + L + L+ +A++LM
Sbjct: 165 VEILEAKA-DGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLS----QAVKLML 219
Query: 93 SMFKTSMYAGAIPRWLRPFIPKPWREFCRSWDGLFKFSQIHVDNKLRDIQYQMDRGRRVS 152
S L F+P ++ + + Q+ D R + + RG V
Sbjct: 220 EGITASRNT------LAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRRE-ALKRGEEVP 272
Query: 153 GGLLTYLFLSQ--ALTLQEIYANVTEMLLAGVDTTSFTLSWTVYLLARHPEVQQTVYREI 210
+LT + ++ A + + N +AG +T++ L++TV L+R PE+ + E+
Sbjct: 273 ADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEV 332
Query: 211 VKNLGERHVPTAADVPKVPLVRALLKETLRLFPVLPGNGRVTQEDLVIGGYLIPKGTQLA 270
+ +G + D+ ++ + +LKE+LRL+P G R+ +E+ +I G +P T L
Sbjct: 333 DEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLL 392
Query: 271 LCHYATSYQDENFPRAKEFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHL 330
Y D F F P+R+ G F PF G RSCIG++ A++E+ +
Sbjct: 393 FSTYVMGRMDTYFEDPLTFNPDRF---GPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKV 449
Query: 331 VVIQLLQHFEIK 342
V+ +LLQ E +
Sbjct: 450 VMAKLLQRLEFR 461
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.140 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,331,848
Number of Sequences: 37866
Number of extensions: 564341
Number of successful extensions: 1243
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 71
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 1031
Number of HSP's gapped (non-prelim): 74
length of query: 372
length of database: 18,247,518
effective HSP length: 104
effective length of query: 268
effective length of database: 14,309,454
effective search space: 3834933672
effective search space used: 3834933672
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.