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Search of human proteins with 166795268
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|166795268 retinol dehydrogenase 11 [Homo sapiens]
(318 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|166795268 retinol dehydrogenase 11 [Homo sapiens] 641 0.0
gi|186928839 retinol dehydrogenase 12 [Homo sapiens] 459 e-129
gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens] 285 3e-77
gi|10190746 retinol dehydrogenase 14 (all-trans and 9-cis) [Homo... 257 8e-69
gi|146231950 dehydrogenase/reductase (SDR family) member 13 [Hom... 244 6e-65
gi|19923931 retinol dehydrogenase 13 isoform 2 [Homo sapiens] 221 5e-58
gi|7706523 WW domain-containing oxidoreductase isoform 1 [Homo s... 196 2e-50
gi|193804850 dehydrogenase/reductase (SDR family) X-linked [Homo... 191 6e-49
gi|13375997 dehydrogenase/reductase (SDR family) member 12 isofo... 85 1e-16
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s... 79 7e-15
gi|72534732 dehydrogenase/reductase (SDR family) member 12 isofo... 78 9e-15
gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens] 73 4e-13
gi|150247226 retinol dehydrogenase 16 [Homo sapiens] 72 8e-13
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa... 70 2e-12
gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens] 69 6e-12
gi|22507405 short chain dehydrogenase/reductase family 9C, membe... 68 1e-11
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo... 63 3e-10
gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo sap... 63 4e-10
gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo... 62 5e-10
gi|7705421 hydroxysteroid (17-beta) dehydrogenase 7 [Homo sapiens] 62 9e-10
gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A... 62 9e-10
gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform ... 60 2e-09
gi|4502601 carbonyl reductase 3 [Homo sapiens] 60 2e-09
gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Hom... 60 2e-09
gi|4557649 estradiol 17 beta-dehydrogenase 3 [Homo sapiens] 60 3e-09
gi|209862901 dehydrogenase/reductase (SDR family) member 1 [Homo... 60 3e-09
gi|19923983 dehydrogenase/reductase (SDR family) member 1 [Homo ... 60 3e-09
gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo... 59 4e-09
gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Hom... 59 4e-09
gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Hom... 59 4e-09
>gi|166795268 retinol dehydrogenase 11 [Homo sapiens]
Length = 318
Score = 641 bits (1653), Expect = 0.0
Identities = 318/318 (100%), Positives = 318/318 (100%)
Query: 1 MVELMFPLLLLLLPFLLYMAAPQIRKMLSSGVCTSTVQLPGKVVVVTGANTGIGKETAKE 60
MVELMFPLLLLLLPFLLYMAAPQIRKMLSSGVCTSTVQLPGKVVVVTGANTGIGKETAKE
Sbjct: 1 MVELMFPLLLLLLPFLLYMAAPQIRKMLSSGVCTSTVQLPGKVVVVTGANTGIGKETAKE 60
Query: 61 LAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKLDLSDTKSIRAFAKGFLAEEKH 120
LAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKLDLSDTKSIRAFAKGFLAEEKH
Sbjct: 61 LAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKLDLSDTKSIRAFAKGFLAEEKH 120
Query: 121 LHVLINNAGVMMCPYSKTADGFEMHIGVNHLGHFLLTHLLLEKLKESAPSRIVNVSSLAH 180
LHVLINNAGVMMCPYSKTADGFEMHIGVNHLGHFLLTHLLLEKLKESAPSRIVNVSSLAH
Sbjct: 121 LHVLINNAGVMMCPYSKTADGFEMHIGVNHLGHFLLTHLLLEKLKESAPSRIVNVSSLAH 180
Query: 181 HLGRIHFHNLQGEKFYNAGLAYCHSKLANILFTQELARRLKGSGVTTYSVHPGTVQSELV 240
HLGRIHFHNLQGEKFYNAGLAYCHSKLANILFTQELARRLKGSGVTTYSVHPGTVQSELV
Sbjct: 181 HLGRIHFHNLQGEKFYNAGLAYCHSKLANILFTQELARRLKGSGVTTYSVHPGTVQSELV 240
Query: 241 RHSSFMRWMWWLFSFFIKTPQQGAQTSLHCALTEGLEILSGNHFSDCHVAWVSAQARNET 300
RHSSFMRWMWWLFSFFIKTPQQGAQTSLHCALTEGLEILSGNHFSDCHVAWVSAQARNET
Sbjct: 241 RHSSFMRWMWWLFSFFIKTPQQGAQTSLHCALTEGLEILSGNHFSDCHVAWVSAQARNET 300
Query: 301 IARRLWDVSCDLLGLPID 318
IARRLWDVSCDLLGLPID
Sbjct: 301 IARRLWDVSCDLLGLPID 318
>gi|186928839 retinol dehydrogenase 12 [Homo sapiens]
Length = 316
Score = 459 bits (1181), Expect = e-129
Identities = 227/313 (72%), Positives = 262/313 (83%), Gaps = 2/313 (0%)
Query: 5 MFPLLLLLLPFL--LYMAAPQIRKMLSSGVCTSTVQLPGKVVVVTGANTGIGKETAKELA 62
M L LL F LYM AP IRK + GVC + VQLPGKVVV+TGANTGIGKETA+ELA
Sbjct: 1 MLVTLGLLTSFFSFLYMVAPSIRKFFAGGVCRTNVQLPGKVVVITGANTGIGKETARELA 60
Query: 63 QRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKLDLSDTKSIRAFAKGFLAEEKHLH 122
RGARVY+ACRDV KGE A EI+ T N QVLVRKLDLSDTKSIRAFA+GFLAEEK LH
Sbjct: 61 SRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLDLSDTKSIRAFAEGFLAEEKQLH 120
Query: 123 VLINNAGVMMCPYSKTADGFEMHIGVNHLGHFLLTHLLLEKLKESAPSRIVNVSSLAHHL 182
+LINNAGVMMCPYSKTADGFE H+GVNHLGHFLLT+LLLE+LK SAP+R+VNVSS+AHH+
Sbjct: 121 ILINNAGVMMCPYSKTADGFETHLGVNHLGHFLLTYLLLERLKVSAPARVVNVSSVAHHI 180
Query: 183 GRIHFHNLQGEKFYNAGLAYCHSKLANILFTQELARRLKGSGVTTYSVHPGTVQSELVRH 242
G+I FH+LQ EK Y+ G AYCHSKLAN+LFT+ELA+RL+G+GVTTY+VHPG V+SELVRH
Sbjct: 181 GKIPFHDLQSEKRYSRGFAYCHSKLANVLFTRELAKRLQGTGVTTYAVHPGVVRSELVRH 240
Query: 243 SSFMRWMWWLFSFFIKTPQQGAQTSLHCALTEGLEILSGNHFSDCHVAWVSAQARNETIA 302
SS + +W LFS F+KT ++GAQTSLHCAL EGLE LSG +FSDC WVS +ARN A
Sbjct: 241 SSLLCLLWRLFSPFVKTAREGAQTSLHCALAEGLEPLSGKYFSDCKRTWVSPRARNNKTA 300
Query: 303 RRLWDVSCDLLGL 315
RLW+VSC+LLG+
Sbjct: 301 ERLWNVSCELLGI 313
>gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]
Length = 331
Score = 285 bits (730), Expect = 3e-77
Identities = 155/306 (50%), Positives = 204/306 (66%), Gaps = 13/306 (4%)
Query: 20 AAPQIRKMLSSGVCTSTVQLPGKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGE 79
AA ++ ++ G C S +PGK V+VTGANTGIGK+TA ELA+RG + LACRD+EK E
Sbjct: 17 AAVLLKDYVTGGACPSKATIPGKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCE 76
Query: 80 LVAKEIQTTTGNQQVLVRKLDLSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCPYSKTA 139
AK+I+ T N V R LDL+ KSIR FA + EE+ + +LINNAGVM CP+ T
Sbjct: 77 AAAKDIRGETLNHHVNARHLDLASLKSIREFAAKIIEEEERVDILINNAGVMRCPHWTTE 136
Query: 140 DGFEMHIGVNHLGHFLLTHLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGE-KFYNA 198
DGFEM GVNHLGHFLLT+LLL+KLK SAPSRI+N+SSLAH G I F +L + + YN
Sbjct: 137 DGFEMQFGVNHLGHFLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNT 196
Query: 199 GLAYCHSKLANILFTQELARRLKGSGVTTYSVHPGTVQSELVRH---------SSFMRWM 249
AYC SKLA +LFT+EL+RRL+GSGVT ++HPG ++EL RH S+ + +
Sbjct: 197 KAAYCQSKLAIVLFTKELSRRLQGSGVTVNALHPGVARTELGRHTGIHGSTFSSTTLGPI 256
Query: 250 WWLFSFFIKTPQQGAQTSLHCALTEGLEILSGNHFSDCHVAWVSAQARNETIARRLWDVS 309
+WL +K+P+ AQ S + A+ E L +SG +F + +A +E +ARRLW S
Sbjct: 257 FWL---LVKSPELAAQPSTYLAVAEELADVSGKYFDGLKQKAPAPEAEDEEVARRLWAES 313
Query: 310 CDLLGL 315
L+GL
Sbjct: 314 ARLVGL 319
>gi|10190746 retinol dehydrogenase 14 (all-trans and 9-cis) [Homo
sapiens]
Length = 336
Score = 257 bits (657), Expect = 8e-69
Identities = 140/292 (47%), Positives = 190/292 (65%), Gaps = 17/292 (5%)
Query: 41 GKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQT------------- 87
GK V++TGAN+G+G+ TA EL + GARV + CRD + E A +++
Sbjct: 43 GKTVLITGANSGLGRATAAELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPEPG 102
Query: 88 TTGNQQVLVRKLDLSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCPYSKTADGFEMHIG 147
+G +++VR+LDL+ +S+RAF + L EE L VLINNAG+ CPY KT DGFEM G
Sbjct: 103 VSGVGELIVRELDLASLRSVRAFCQEMLQEEPRLDVLINNAGIFQCPYMKTEDGFEMQFG 162
Query: 148 VNHLGHFLLTHLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKL 207
VNHLGHFLLT+LLL LK SAPSRIV VSS + G I+F +L E+ YN Y SKL
Sbjct: 163 VNHLGHFLLTNLLLGLLKSSAPSRIVVVSSKLYKYGDINFDDLNSEQSYNKSFCYSRSKL 222
Query: 208 ANILFTQELARRLKGSGVTTYSVHPGTVQSELVRHSSFMRWMWWLFSF----FIKTPQQG 263
ANILFT+ELARRL+G+ VT +HPG V++ L RH + LF+ F KTP +G
Sbjct: 223 ANILFTRELARRLEGTNVTVNVLHPGIVRTNLGRHIHIPLLVKPLFNLVSWAFFKTPVEG 282
Query: 264 AQTSLHCALTEGLEILSGNHFSDCHVAWVSAQARNETIARRLWDVSCDLLGL 315
AQTS++ A + +E +SG +F DC + +A +E++AR+LWD+S ++GL
Sbjct: 283 AQTSIYLASSPEVEGVSGRYFGDCKEEELLPKAMDESVARKLWDISEVMVGL 334
>gi|146231950 dehydrogenase/reductase (SDR family) member 13 [Homo
sapiens]
Length = 377
Score = 244 bits (624), Expect = 6e-65
Identities = 139/291 (47%), Positives = 185/291 (63%), Gaps = 13/291 (4%)
Query: 33 CTSTVQLPGKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQ 92
C L G+ VVTGAN+GIGK TA ELA+RGARV LACR E+GE A +++ +GN
Sbjct: 28 CGGMGNLRGRTAVVTGANSGIGKMTALELARRGARVVLACRSQERGEAAAFDLRQESGNN 87
Query: 93 QVLVRKLDLSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCPYSKTADGFEMHIGVNHLG 152
+V+ LDL+ S+RAFA FL+ E L +LI+NAG+ C +T + F + + VNH+G
Sbjct: 88 EVIFMALDLASLASVRAFATAFLSSEPRLDILIHNAGISSC--GRTREAFNLLLRVNHIG 145
Query: 153 HFLLTHLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGE--KFYNAGLAYCHSKLANI 210
FLLTHLLL LK APSR+V V+S AH GR+ F L + AY +KLAN+
Sbjct: 146 PFLLTHLLLPCLKACAPSRVVVVASAAHCRGRLDFKRLDRPVVGWRQELRAYADTKLANV 205
Query: 211 LFTQELARRLKGSGVTTYSVHPGTVQSEL-VRH-----SSFMRWMWWLFSFFIKTPQQGA 264
LF +ELA +L+ +GVT Y+ HPG V SEL +RH +R + WL ++ P+ GA
Sbjct: 206 LFARELANQLEATGVTCYAAHPGPVNSELFLRHVPGWLRPLLRPLAWL---VLRAPRGGA 262
Query: 265 QTSLHCALTEGLEILSGNHFSDCHVAWVSAQARNETIARRLWDVSCDLLGL 315
QT L+CAL EG+E LSG +F++CHV V AR++ A RLW+ S L GL
Sbjct: 263 QTPLYCALQEGIEPLSGRYFANCHVEEVPPAARDDRAAHRLWEASKRLAGL 313
>gi|19923931 retinol dehydrogenase 13 isoform 2 [Homo sapiens]
Length = 260
Score = 221 bits (564), Expect = 5e-58
Identities = 124/251 (49%), Positives = 164/251 (65%), Gaps = 13/251 (5%)
Query: 75 VEKGELVAKEIQTTTGNQQVLVRKLDLSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCP 134
+EK E AK+I+ T N V R LDL+ KSIR FA + EE+ + +LINNAGVM CP
Sbjct: 1 MEKCEAAAKDIRGETLNHHVNARHLDLASLKSIREFAAKIIEEEERVDILINNAGVMRCP 60
Query: 135 YSKTADGFEMHIGVNHLGHFLLTHLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGE- 193
+ T DGFEM GVNHLGHFLLT+LLL+KLK SAPSRI+N+SSLAH G I F +L +
Sbjct: 61 HWTTEDGFEMQFGVNHLGHFLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQT 120
Query: 194 KFYNAGLAYCHSKLANILFTQELARRLKGSGVTTYSVHPGTVQSELVRH---------SS 244
+ YN AYC SKLA +LFT+EL+RRL+GSGVT ++HPG ++EL RH S+
Sbjct: 121 RKYNTKAAYCQSKLAIVLFTKELSRRLQGSGVTVNALHPGVARTELGRHTGIHGSTFSST 180
Query: 245 FMRWMWWLFSFFIKTPQQGAQTSLHCALTEGLEILSGNHFSDCHVAWVSAQARNETIARR 304
+ ++WL +K+P+ AQ S + A+ E L +SG +F + +A +E +ARR
Sbjct: 181 TLGPIFWL---LVKSPELAAQPSTYLAVAEELADVSGKYFDGLKQKAPAPEAEDEEVARR 237
Query: 305 LWDVSCDLLGL 315
LW S L+GL
Sbjct: 238 LWAESARLVGL 248
>gi|7706523 WW domain-containing oxidoreductase isoform 1 [Homo
sapiens]
Length = 414
Score = 196 bits (499), Expect = 2e-50
Identities = 121/284 (42%), Positives = 160/284 (56%), Gaps = 21/284 (7%)
Query: 41 GKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKLD 100
GKVVVVTGAN+GIG ETAK A GA V LACR++ + I +V LD
Sbjct: 124 GKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWHKAKVEAMTLD 183
Query: 101 LSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCPYSKTADGFEMHIGVNHLGHFLLTHLL 160
L+ +S++ FA+ F A+ LHVL+ NA P+S T DG E VNHLGHF L LL
Sbjct: 184 LALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLVQLL 243
Query: 161 LEKLKESAPSRIVNVSSLAHH-------LGRIHFHNLQGEK-FYNAGLAYCHSKLANILF 212
+ L SAP+R++ VSS +H LG++ F L K Y A LAY SKL NILF
Sbjct: 244 QDVLCRSAPARVIVVSSESHRFTDINDSLGKLDFSRLSPTKNDYWAMLAYNRSKLCNILF 303
Query: 213 TQELARRLKGSGVTTYSVHPGTVQSELVRHSSFMRWMWWLFSF-------FIKTPQQGAQ 265
+ EL RRL GVT+ +VHPG + + S WW+++ F K+ QQGA
Sbjct: 304 SNELHRRLSPRGVTSNAVHPGNMMYSNIHRS------WWVYTLLFTLARPFTKSMQQGAA 357
Query: 266 TSLHCALTEGLEILSGNHFSDCHVAWVSAQARNETIARRLWDVS 309
T+++CA LE L G +F++C S +A++E AR LW +S
Sbjct: 358 TTVYCAAVPELEGLGGMYFNNCCRCMPSPEAQSEETARTLWALS 401
>gi|193804850 dehydrogenase/reductase (SDR family) X-linked [Homo
sapiens]
Length = 330
Score = 191 bits (486), Expect = 6e-49
Identities = 115/287 (40%), Positives = 164/287 (57%), Gaps = 14/287 (4%)
Query: 40 PGKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKL 99
P +V +VTG GIG TAK LA+ G V +A + K + V +I+ T N +V
Sbjct: 42 PDRVAIVTGGTDGIGYSTAKHLARLGMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFLYC 101
Query: 100 DLSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCPYSKTADGFEMHIGVNHLGHFLLTHL 159
DL+ SIR F + F ++ LHVLINNAGVMM P KT DGFE H G+N+LGHFLLT+L
Sbjct: 102 DLASMTSIRQFVQKFKMKKIPLHVLINNAGVMMVPQRKTRDGFEEHFGLNYLGHFLLTNL 161
Query: 160 LLEKLKESA----PSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANILFTQE 215
LL+ LKES +R+V VSS H++ ++ +LQ Y+ AY SKLA +LFT
Sbjct: 162 LLDTLKESGSPGHSARVVTVSSATHYVAELNMDDLQSSACYSPHAAYAQSKLALVLFTYH 221
Query: 216 LARRL--KGSGVTTYSVHPGTVQSELVRHSSF-----MRWMWWLFSFFIKTPQQGAQTSL 268
L R L +GS VT V PG V +++ +H + + + WL KTP +GA TS+
Sbjct: 222 LQRLLAAEGSHVTANVVDPGVVNTDVYKHVFWATRLAKKLLGWL---LFKTPDEGAWTSI 278
Query: 269 HCALTEGLEILSGNHFSDCHVAWVSAQARNETIARRLWDVSCDLLGL 315
+ A+T LE + G++ + N+ + ++LW SC++ G+
Sbjct: 279 YAAVTPELEGVGGHYLYNEKETKSLHVTYNQKLQQQLWSKSCEMTGV 325
>gi|13375997 dehydrogenase/reductase (SDR family) member 12 isoform
2 [Homo sapiens]
Length = 242
Score = 84.7 bits (208), Expect = 1e-16
Identities = 60/200 (30%), Positives = 104/200 (52%), Gaps = 6/200 (3%)
Query: 75 VEKGELVAKEIQTTTGNQQVLVRKLDLSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCP 134
+E+ +AK++ + ++ + + +DLSD K I F + F E K LHVLINNAG M+
Sbjct: 25 LEETAALAKQLPLKSPSENIFLHIVDLSDPKQIWKFVENFKQEHK-LHVLINNAGCMVNK 83
Query: 135 YSKTADGFEMHIGVNHLGHFLLTHLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGEK 194
T DG E + N LG ++LT L+ L++ R++ VSS + +++ ++LQ E+
Sbjct: 84 RELTEDGLEKNFAANTLGVYILTTGLIPVLEKEHDPRVITVSSGGMLVQKLNTNDLQSER 143
Query: 195 F-YNAGLAYCHSKLANILFTQELARRLKGSGVTTYSVHPGTVQSELVRHSSFMRWMWWLF 253
++ + Y +K ++ T+ A+ + S+HPG + VR + M F
Sbjct: 144 TPFDGTMVYAQNKRQQVVLTERWAQ--GHPAIHFSSMHPGWADTPGVRQA--MPGFHARF 199
Query: 254 SFFIKTPQQGAQTSLHCALT 273
+++ QGA T L AL+
Sbjct: 200 GDRLRSEAQGADTMLWLALS 219
>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
sapiens]
Length = 339
Score = 78.6 bits (192), Expect = 7e-15
Identities = 79/253 (31%), Positives = 118/253 (46%), Gaps = 31/253 (12%)
Query: 8 LLLLLLPFLLYMAAPQIRKMLSSGVCT----------STVQLPGKVVVVTGANTGIGKET 57
L LL+L LL + +R + + G T +L VV VTGA++GIG+E
Sbjct: 7 LWLLVLCALLLLLVQLLRFLRADGDLTLLWAEWQGRRPEWELTDMVVWVTGASSGIGEEL 66
Query: 58 AKELAQRGARVYLACRDVEKGELVAKEIQTTTGN---QQVLVRKLDLSDTKSIRAFAKGF 114
A +L++ G + L+ R V + E V + GN + +LV LDL+DT S A K
Sbjct: 67 AYQLSKLGVSLVLSARRVHELERVKRRC-LENGNLKEKDILVLPLDLTDTGSHEAATKAV 125
Query: 115 LAEEKHLHVLINNAGV---MMCPYSKTADGFEMHIGVNHLGHFLLTHLLLEKLKESAPSR 171
L E + +L+NN G+ +C + D + I +N+LG LT +L + E +
Sbjct: 126 LQEFGRIDILVNNGGMSQRSLC-MDTSLDVYRKLIELNYLGTVSLTKCVLPHMIERKQGK 184
Query: 172 IVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANILFTQELARRLKG-SGVTTYSV 230
IV V+S+ LG I + YC SK A F L L G+ ++
Sbjct: 185 IVTVNSI---LGIIS---------VPLSIGYCASKHALRGFFNGLRTELATYPGIIVSNI 232
Query: 231 HPGTVQSELVRHS 243
PG VQS +V +S
Sbjct: 233 CPGPVQSNIVENS 245
>gi|72534732 dehydrogenase/reductase (SDR family) member 12 isoform
1 [Homo sapiens]
Length = 271
Score = 78.2 bits (191), Expect = 9e-15
Identities = 49/160 (30%), Positives = 87/160 (54%), Gaps = 4/160 (2%)
Query: 75 VEKGELVAKEIQTTTGNQQVLVRKLDLSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCP 134
+E+ +AK++ + ++ + + +DLSD K I F + F E K LHVLINNAG M+
Sbjct: 25 LEETAALAKQLPLKSPSENIFLHIVDLSDPKQIWKFVENFKQEHK-LHVLINNAGCMVNK 83
Query: 135 YSKTADGFEMHIGVNHLGHFLLTHLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGEK 194
T DG E + N LG ++LT L+ L++ R++ VSS + +++ ++LQ E+
Sbjct: 84 RELTEDGLEKNFAANTLGVYILTTGLIPVLEKEHDPRVITVSSGGMLVQKLNTNDLQSER 143
Query: 195 F-YNAGLAYCHSKLANILFTQELARRLKGSGVTTYSVHPG 233
++ + Y +K ++ T+ A+ + S+HPG
Sbjct: 144 TPFDGTMVYAQNKRQQVVLTERWAQ--GHPAIHFSSMHPG 181
>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
Length = 300
Score = 72.8 bits (177), Expect = 4e-13
Identities = 70/242 (28%), Positives = 111/242 (45%), Gaps = 24/242 (9%)
Query: 9 LLLLLPFLLYMAAPQIRKMLSSGVCTSTVQLPGKVVVVTGANTGIGKETAKELAQRGARV 68
+LLLLP L+ + K+ + + G++V++TGA GIG+ TA E A+ +++
Sbjct: 7 ILLLLPLLIVCSLESFVKLF---IPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLKSKL 63
Query: 69 YLACRDVEKGELVAKEIQTTTGNQQVLVRKLDLSDTKSIRAFAKGFLAEEKHLHVLINNA 128
L D+ K L + +V +D S+ + I + AK AE + +L+NNA
Sbjct: 64 VL--WDINKHGLEETAAKCKGLGAKVHTFVVDCSNREDIYSSAKKVKAEIGDVSILVNNA 121
Query: 129 GVMMCP--YSKTADGFEMHIGVNHLGHFLLTHLLLEKLKESAPSRIVNVSSLAHHLGRIH 186
GV+ ++ E VN L HF T L + ++ IV V+S A H+
Sbjct: 122 GVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVPF 181
Query: 187 FHNLQGEKFYNAGLAYCHSKLANILF----TQELARRLKGSGVTTYSVHPGTVQSELVRH 242
LAYC SK A + F T ELA L+ +GV T + P V + +++
Sbjct: 182 L------------LAYCSSKFAAVGFHKTLTDELA-ALQITGVKTTCLCPNFVNTGFIKN 228
Query: 243 SS 244
S
Sbjct: 229 PS 230
>gi|150247226 retinol dehydrogenase 16 [Homo sapiens]
Length = 317
Score = 71.6 bits (174), Expect = 8e-13
Identities = 68/214 (31%), Positives = 101/214 (47%), Gaps = 24/214 (11%)
Query: 39 LPGKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRK 98
L K V +TG ++G GK A++L RG RV AC EKG A++++ T ++ V
Sbjct: 27 LRDKYVFITGCDSGFGKLLARQLDARGLRVLAACL-TEKG---AEQLRGQTSDRLETV-T 81
Query: 99 LDLSDTKSIRAFAKGF--LAEEKHLHVLINNAGVMMCPYSK---TADGFEMHIGVNHLGH 153
LD++ T+S+ A A+ +K L L+NNAG+ + T F + VN LG
Sbjct: 82 LDVTKTESVAAAAQWVKECVRDKGLWGLVNNAGISLPTAPNELLTKQDFVTILDVNLLGV 141
Query: 154 FLLTHLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANILFT 213
+T L L L A R+VNVSS+ +GR+ G YC SK F+
Sbjct: 142 IDVT-LSLLPLVRRARGRVVNVSSV---MGRVSLF----------GGGYCISKYGVEAFS 187
Query: 214 QELARRLKGSGVTTYSVHPGTVQSELVRHSSFMR 247
L R L GV + PG ++ + F++
Sbjct: 188 DSLRRELSYFGVKVAMIEPGYFKTAVTSKERFLK 221
>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
sapiens]
Length = 332
Score = 70.1 bits (170), Expect = 2e-12
Identities = 64/203 (31%), Positives = 95/203 (46%), Gaps = 13/203 (6%)
Query: 4 LMFPLLLLLLPFLLYMAAPQIRKMLSSGVCTSTVQLPGKVVVVTGANTGIGKETAKELAQ 63
L+ L+ LLYM +P I + LPG VVVTG ++GIGK A E +
Sbjct: 3 LLAAAFLVAFVLLLYMVSPLISP--------KPLALPGAHVVVTGGSSGIGKCIAIECYK 54
Query: 64 RGARVYLACRDVEKGELVAKEIQTTTGN--QQVLVRKLDLS-DTKSIRAFAKGFLAEEKH 120
+GA + L R+ +K KEI+ + N Q VL +D+S D + K +
Sbjct: 55 QGAFITLVARNEDKLLQAKKEIEMHSINDKQVVLCISVDVSQDYNQVENVIKQAQEKLGP 114
Query: 121 LHVLINNAGVMMCPYSKTAD--GFEMHIGVNHLGHFLLTHLLLEKLKESAPSRIVNVSSL 178
+ +L+N AG+ + + + FE + +N+LG + ++ +KE RIV VSS
Sbjct: 115 VDMLVNCAGMAVSGKFEDLEVSTFERLMSINYLGSVYPSRAVITTMKERRVGRIVFVSSQ 174
Query: 179 AHHLGRIHFHNLQGEKFYNAGLA 201
A LG F KF GLA
Sbjct: 175 AGQLGLFGFTAYSASKFAIRGLA 197
>gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]
Length = 317
Score = 68.9 bits (167), Expect = 6e-12
Identities = 82/255 (32%), Positives = 122/255 (47%), Gaps = 32/255 (12%)
Query: 39 LPGKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRK 98
L K V +TG ++G G A++L RG RV AC EKG A++++ T ++ V
Sbjct: 27 LQDKYVFITGCDSGFGNLLARQLDARGLRVLAACL-TEKG---AEQLRGQTSDRLETV-T 81
Query: 99 LDLSDTKSIRAFAKGFLAE---EKHLHVLINNAGVM----MCPYSKTADGFEMHIGVNHL 151
LD++ +SI A A ++ E ++ L L+NNAG++ +C + T D M + VN +
Sbjct: 82 LDVTKMESIAA-ATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTEDSMNM-LKVNLI 139
Query: 152 GHFLLTHLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANIL 211
G +T L + L A RIVNVSS+ LGR+ F+ G YC SK
Sbjct: 140 GVIQVT-LSMLPLVRRARGRIVNVSSI---LGRV--------AFFVGG--YCVSKYGVEA 185
Query: 212 FTQELARRLKGSGVTTYSVHPG---TVQSELVRHSSFMRWMWWLFSFFIK-TPQQGAQTS 267
F+ L R ++ GV V PG T + + + M+ W IK T Q +
Sbjct: 186 FSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQQYFDA 245
Query: 268 LHCALTEGLEILSGN 282
L+ + EGL S N
Sbjct: 246 LYNIMKEGLLNCSTN 260
>gi|22507405 short chain dehydrogenase/reductase family 9C, member 7
[Homo sapiens]
Length = 313
Score = 67.8 bits (164), Expect = 1e-11
Identities = 67/230 (29%), Positives = 102/230 (44%), Gaps = 35/230 (15%)
Query: 33 CTSTVQLPGKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKE----IQTT 88
C L K V +TG ++G G AK+L RG +V AC E + + ++ +QTT
Sbjct: 17 CNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEEGSQKLQRDTSYRLQTT 76
Query: 89 TGNQQVLVRKLDLSDTKSIRAFAKGFLAE--EKHLHVLINNAGVMMCPYSK---TADGFE 143
LD++ ++SI+A A+ + E+ L L+NNAGV + T D F
Sbjct: 77 L---------LDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEWLTKDDFV 127
Query: 144 MHIGVNHLGHFLLTHLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYC 203
I VN +G +T +L +K A R+VN+SS G + G YC
Sbjct: 128 KVINVNLVGLIEVTLHMLPMVKR-ARGRVVNMSS-------------SGGRVAVIGGGYC 173
Query: 204 HSKLANILFTQELARRLKGSGVTTYSVHPGTVQSELV---RHSSFMRWMW 250
SK F+ + R L GV + PG ++ ++ S MR +W
Sbjct: 174 VSKFGVEAFSDSIRRELYYFGVKVCIIEPGNYRTAILGKENLESRMRKLW 223
>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
sapiens]
Length = 270
Score = 63.2 bits (152), Expect = 3e-10
Identities = 55/202 (27%), Positives = 86/202 (42%), Gaps = 22/202 (10%)
Query: 41 GKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKLD 100
GKVVVVTG GIG + GARV + +D G + +E+ G +L D
Sbjct: 9 GKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQEL---PGAVFIL---CD 62
Query: 101 LSDTKSIRAFAKGFLAEEKHLHVLINNAG---VMMCPYSKTADGFEMHIGVNHLGHFLLT 157
++ ++ + L ++NNAG P +A GF + +N LG + LT
Sbjct: 63 VTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLT 122
Query: 158 HLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANILFTQELA 217
L L L++S ++N+SSL +G+ + Y +K A T+ LA
Sbjct: 123 KLALPYLRKS-QGNVINISSLVGAIGQAQ------------AVPYVATKGAVTAMTKALA 169
Query: 218 RRLKGSGVTTYSVHPGTVQSEL 239
GV + PG + + L
Sbjct: 170 LDESPYGVRVNCISPGNIWTPL 191
>gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo
sapiens]
Length = 318
Score = 62.8 bits (151), Expect = 4e-10
Identities = 58/196 (29%), Positives = 93/196 (47%), Gaps = 26/196 (13%)
Query: 44 VVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKLDLSD 103
V +TG ++G G+ A +L QRG RV +C E + + + ++ LD++D
Sbjct: 31 VFITGCDSGFGRLLALQLDQRGFRVLASCLTPSGAEDLQR-----VASSRLHTTLLDITD 85
Query: 104 TKSIRAFAK--GFLAEEKHLHVLINNAGVM----MCPYSKTADGFEMHIGVNHLGHFLLT 157
+S++ AK +E L L+NNAGV P+ T D F+ + VN +G +T
Sbjct: 86 PQSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIGPTPW-LTRDDFQRVLNVNTMGPIGVT 144
Query: 158 HLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANILFTQELA 217
LL L++ A R++N++S+ LGR+ + G YC SK F+ L
Sbjct: 145 LALLPLLQQ-ARGRVINITSV---LGRLAAN----------GGGYCVSKFGLEAFSDSLR 190
Query: 218 RRLKGSGVTTYSVHPG 233
R + G+ V PG
Sbjct: 191 RDVAHFGIRVSIVEPG 206
>gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo
sapiens]
Length = 330
Score = 62.4 bits (150), Expect = 5e-10
Identities = 64/217 (29%), Positives = 98/217 (45%), Gaps = 20/217 (9%)
Query: 41 GKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKLD 100
G+ VV+GA GIGK A+ELA RG + L R+ EK ++VAK+I T + ++ D
Sbjct: 67 GRWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKLQVVAKDIADTYKVETDII-VAD 125
Query: 101 LSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCPYSK-----TADGFEMHIGVNHLGHFL 155
S + I + L ++K + +L+NN GV PY + + D I VN L
Sbjct: 126 FSSGREIYLPIREAL-KDKDVGILVNNVGVFY-PYPQYFTQLSEDKLWDIINVNIAAASL 183
Query: 156 LTHLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANILFTQE 215
+ H++L + E IV +SS G Q F +A AY F++
Sbjct: 184 MVHVVLPGMVERKKGAIVTISS-----GSCCKPTPQLAAF-SASKAYLDH------FSRA 231
Query: 216 LARRLKGSGVTTYSVHPGTVQSELVRHSSFMRWMWWL 252
L G+ S+ P V + + S+F+ WL
Sbjct: 232 LQYEYASKGIFVQSLIPFYVATSMTAPSNFLHRCSWL 268
>gi|7705421 hydroxysteroid (17-beta) dehydrogenase 7 [Homo sapiens]
Length = 341
Score = 61.6 bits (148), Expect = 9e-10
Identities = 60/231 (25%), Positives = 95/231 (41%), Gaps = 36/231 (15%)
Query: 42 KVVVVTGANTGIGKETAKELAQRGARVYL--ACRDVEKGELVAKEIQTTTGNQQVLVRKL 99
KVV++TGA++GIG K L ++L ACR++ K E V + + +V + ++
Sbjct: 3 KVVLITGASSGIGLALCKRLLAEDDELHLCLACRNMSKAEAVCAALLASHPTAEVTIVQV 62
Query: 100 DLSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCP-----------YSK----------- 137
D+S+ +S+ +K + L + NAG+M P +S+
Sbjct: 63 DVSNLQSVFRASKELKQRFQRLDCIYLNAGIMPNPQLNIKALFFGLFSRKVIHMFSTAEG 122
Query: 138 --------TADGFEMHIGVNHLGHFLLTHLLLEKLKES-APSRIVNVSSLAHHLGRIHFH 188
TADG + N GHF+L L L S PS+++ SS +
Sbjct: 123 LLTQGDKITADGLQEVFETNVFGHFILIRELEPLLCHSDNPSQLIWTSSRSARKSNFSLE 182
Query: 189 NLQGEKFYNAGLAYCHSKLANILFTQELARRLKGSGVTTYSVHPGTVQSEL 239
+ Q K Y SK A L + L R G+ + PGT + L
Sbjct: 183 DFQHSK---GKEPYSSSKYATDLLSVALNRNFNQQGLYSNVACPGTALTNL 230
>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
[Homo sapiens]
Length = 300
Score = 61.6 bits (148), Expect = 9e-10
Identities = 62/245 (25%), Positives = 103/245 (42%), Gaps = 22/245 (8%)
Query: 9 LLLLLPFLLYMAAPQIRKMLSSGVCTSTVQLPGKVVVVTGANTGIGKETAKELAQRGARV 68
+LLLL ++Y + K + + G++V++TGA GIG++T E A+R + +
Sbjct: 7 ILLLLITIIYSYLESLVKFF---IPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQSIL 63
Query: 69 YLACRDVEKGELVAKEIQTTTGNQQVLVRKLDLSDTKSIRAFAKGFLAEEKHLHVLINNA 128
L + E A E + V +D S+ + I E + +++NNA
Sbjct: 64 VLWDINKRGVEETAAECRKLGVTAHAYV--VDCSNREEIYRSLNQVKKEVGDVTIVVNNA 121
Query: 129 GVMMCP--YSKTADGFEMHIGVNHLGHFLLTHLLLEKLKESAPSRIVNVSSLAHHLGRIH 186
G + S + VN LGHF +T LL + E IV V+S+ H G +
Sbjct: 122 GTVYPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEGIPY 181
Query: 187 FHNLQGEKFYNAGLAYCHSKLANILFTQELARRLKG---SGVTTYSVHPGTVQSELVRHS 243
+ YC SK A + F + L L+ +G+ T + P V + ++
Sbjct: 182 L------------IPYCSSKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNTGFTKNP 229
Query: 244 SFMRW 248
S W
Sbjct: 230 STRLW 234
>gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 1
[Homo sapiens]
Length = 266
Score = 60.5 bits (145), Expect = 2e-09
Identities = 57/205 (27%), Positives = 92/205 (44%), Gaps = 23/205 (11%)
Query: 41 GKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKLD 100
GKV +VTGA GIG+ A+ L +GA+V L ++E G + Q+ L + D
Sbjct: 5 GKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCD 64
Query: 101 LSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCPYSKTADGFEMHIGVNHLGHFLLTHLL 160
++D + +R + + L +L+NNAGV +E + +N + T+L
Sbjct: 65 VADQQQLRDTFRKVVDHFGRLDILVNNAGV------NNEKNWEKTLQINLVSVISGTYLG 118
Query: 161 LEKLKESAPSR---IVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANILFTQE-- 215
L+ + + I+N+SSLA G YC SK + FT+
Sbjct: 119 LDYMSKQNGGEGGIIINMSSLA------------GLMPVAQQPVYCASKHGIVGFTRSAA 166
Query: 216 LARRLKGSGVTTYSVHPGTVQSELV 240
LA L SGV ++ PG V + ++
Sbjct: 167 LAANLMNSGVRLNAICPGFVNTAIL 191
>gi|4502601 carbonyl reductase 3 [Homo sapiens]
Length = 277
Score = 60.5 bits (145), Expect = 2e-09
Identities = 72/270 (26%), Positives = 115/270 (42%), Gaps = 58/270 (21%)
Query: 42 KVVVVTGANTGIGKETAKELAQR-GARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKLD 100
+V +VTGAN GIG A+EL ++ V L RDV +G+ +++Q + + +LD
Sbjct: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRF--HQLD 63
Query: 101 LSDTKSIRAFAKGFLAEEKHLHVLINNAGVMM-----CPYSKTADGFEMHIGVNHLGHFL 155
+ D +SIRA E L+VL+NNA V P+ A EM + N
Sbjct: 64 IDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKA---EMTLKTNFFATRN 120
Query: 156 LTHLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLA-------------- 201
+ + LL +K R+VN+SSL + E+F++ L
Sbjct: 121 MCNELLPIMKPH--GRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVED 178
Query: 202 ---------------YCHSKLANILFTQELARRL----KGSGVTTYSVHPGTVQSELVRH 242
Y SKL + ++ LARRL K + + PG V++++
Sbjct: 179 TKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGK 238
Query: 243 SSFMRWMWWLFSFFIKTPQQGAQTSLHCAL 272
S I+T ++GA+T ++ AL
Sbjct: 239 DS------------IRTVEEGAETPVYLAL 256
>gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Homo
sapiens]
Length = 311
Score = 60.5 bits (145), Expect = 2e-09
Identities = 74/263 (28%), Positives = 111/263 (42%), Gaps = 25/263 (9%)
Query: 1 MVELMFPLLLLLLPFLLYMAAPQIRKMLSSGVCTSTVQLPGKVVVVTGANTGIGKETAKE 60
M LM PLLLL + LL++ R S V KVVV+T A +G+GKE A+
Sbjct: 4 MAMLMLPLLLLGISGLLFIYQEVSRLWSKSAV-------QNKVVVITDAISGLGKECARV 56
Query: 61 LAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRK---LDLSDTKSIRAFAKGFLAE 117
GAR+ L ++ E+ E + + + + K LDLSD + AK L
Sbjct: 57 FHTGGARLVLCGKNWERLENLYDALISVADPSKTFTPKLVLLDLSDISCVPDVAKEVLDC 116
Query: 118 EKHLHVLINNAGV-MMCPYSKTADGFEMHI-GVNHLGHFLLTHLLLEKLKESAPSRIVNV 175
+ +LINNA V + P K + + I N+ G LT LL + +IV V
Sbjct: 117 YGCVDILINNASVKVKGPAHKISLELDKKIMDANYFGPITLTKALLPNMISRRTGQIVLV 176
Query: 176 SSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANILFTQELARRLKGSGVTTYSVHPGTV 235
+N+QG+ Y SK A + F L ++ V +V P +
Sbjct: 177 ------------NNIQGKFGIPFRTTYAASKHAALGFFDCLRAEVEEYDVVISTVSPTFI 224
Query: 236 QSELVRHSSFMRWMWWLFSFFIK 258
+S V + W ++ FF +
Sbjct: 225 RSYHV-YPEQGNWEASIWKFFFR 246
>gi|4557649 estradiol 17 beta-dehydrogenase 3 [Homo sapiens]
Length = 310
Score = 59.7 bits (143), Expect = 3e-09
Identities = 46/141 (32%), Positives = 71/141 (50%), Gaps = 7/141 (4%)
Query: 41 GKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKLD 100
G+ V+TGA GIGK + ELA+RG V L R +EK E +A EI+ TTG +++
Sbjct: 48 GQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADF 107
Query: 101 LSDTKSIRAFAKGFLAEEKHLHVLINNAGVM--MCP--YSKTADGFEMHIGVNHLGHFLL 156
D I K LA + +L+NN G++ + P + D + I N +
Sbjct: 108 TKD--DIYEHIKEKLA-GLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVVKM 164
Query: 157 THLLLEKLKESAPSRIVNVSS 177
T L+L+ ++ I+N+SS
Sbjct: 165 TQLILKHMESRQKGLILNISS 185
>gi|209862901 dehydrogenase/reductase (SDR family) member 1 [Homo
sapiens]
Length = 313
Score = 59.7 bits (143), Expect = 3e-09
Identities = 60/211 (28%), Positives = 97/211 (45%), Gaps = 25/211 (11%)
Query: 41 GKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKLD 100
G+V VVTGA+ GIG+ A +L + GA VY+ R ++ +VA+E Q+ G Q + D
Sbjct: 7 GQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGG--QCVPVVCD 64
Query: 101 LSDTKSIRA-FAKGFLAEEKHLHVLINN--AGVMMCPYSKTADGFE----MHIGVNHL-- 151
S +R+ F + ++ L VL+NN AGV ++ +E M +N++
Sbjct: 65 SSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDINNVGL 124
Query: 152 -GHFLLTHLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANI 210
GH+ + + + IV +SS G Y + Y K A
Sbjct: 125 RGHYFCSVYGARLMVPAGQGLIVVISS-------------PGSLQYMFNVPYGVGKAACD 171
Query: 211 LFTQELARRLKGSGVTTYSVHPGTVQSELVR 241
+ A L+ GV+ S+ PG VQ+EL++
Sbjct: 172 KLAADCAHELRRHGVSCVSLWPGIVQTELLK 202
>gi|19923983 dehydrogenase/reductase (SDR family) member 1 [Homo
sapiens]
Length = 313
Score = 59.7 bits (143), Expect = 3e-09
Identities = 60/211 (28%), Positives = 97/211 (45%), Gaps = 25/211 (11%)
Query: 41 GKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKLD 100
G+V VVTGA+ GIG+ A +L + GA VY+ R ++ +VA+E Q+ G Q + D
Sbjct: 7 GQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGG--QCVPVVCD 64
Query: 101 LSDTKSIRA-FAKGFLAEEKHLHVLINN--AGVMMCPYSKTADGFE----MHIGVNHL-- 151
S +R+ F + ++ L VL+NN AGV ++ +E M +N++
Sbjct: 65 SSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDINNVGL 124
Query: 152 -GHFLLTHLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANI 210
GH+ + + + IV +SS G Y + Y K A
Sbjct: 125 RGHYFCSVYGARLMVPAGQGLIVVISS-------------PGSLQYMFNVPYGVGKAACD 171
Query: 211 LFTQELARRLKGSGVTTYSVHPGTVQSELVR 241
+ A L+ GV+ S+ PG VQ+EL++
Sbjct: 172 KLAADCAHELRRHGVSCVSLWPGIVQTELLK 202
>gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 59.3 bits (142), Expect = 4e-09
Identities = 60/203 (29%), Positives = 95/203 (46%), Gaps = 24/203 (11%)
Query: 42 KVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKLDL 101
K + +TG ++G G A+ ++G V AC E G A + +T+ + VL LD+
Sbjct: 30 KYIFITGCDSGFGNLAARTFDKKGFHVIAACL-TESGS-TALKAETSERLRTVL---LDV 84
Query: 102 SDTKSIRAFAKGFLAE--EKHLHVLINNAGV--MMCPYS-KTADGFEMHIGVNHLGHFLL 156
+D ++++ A+ + EK L LINNAGV ++ P T + + I VN G +
Sbjct: 85 TDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISV 144
Query: 157 THLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANILFTQEL 216
T +L +K+ A R++NVSS+ L + G Y SK A F L
Sbjct: 145 TLNMLPLVKK-AQGRVINVSSVGGRLAIV-------------GGGYTPSKYAVEGFNDSL 190
Query: 217 ARRLKGSGVTTYSVHPGTVQSEL 239
R +K GV + PG ++ L
Sbjct: 191 RRDMKAFGVHVSCIEPGLFKTNL 213
>gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 59.3 bits (142), Expect = 4e-09
Identities = 60/203 (29%), Positives = 95/203 (46%), Gaps = 24/203 (11%)
Query: 42 KVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKLDL 101
K + +TG ++G G A+ ++G V AC E G A + +T+ + VL LD+
Sbjct: 30 KYIFITGCDSGFGNLAARTFDKKGFHVIAACL-TESGS-TALKAETSERLRTVL---LDV 84
Query: 102 SDTKSIRAFAKGFLAE--EKHLHVLINNAGV--MMCPYS-KTADGFEMHIGVNHLGHFLL 156
+D ++++ A+ + EK L LINNAGV ++ P T + + I VN G +
Sbjct: 85 TDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISV 144
Query: 157 THLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANILFTQEL 216
T +L +K+ A R++NVSS+ L + G Y SK A F L
Sbjct: 145 TLNMLPLVKK-AQGRVINVSSVGGRLAIV-------------GGGYTPSKYAVEGFNDSL 190
Query: 217 ARRLKGSGVTTYSVHPGTVQSEL 239
R +K GV + PG ++ L
Sbjct: 191 RRDMKAFGVHVSCIEPGLFKTNL 213
>gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 59.3 bits (142), Expect = 4e-09
Identities = 60/203 (29%), Positives = 95/203 (46%), Gaps = 24/203 (11%)
Query: 42 KVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKLDL 101
K + +TG ++G G A+ ++G V AC E G A + +T+ + VL LD+
Sbjct: 30 KYIFITGCDSGFGNLAARTFDKKGFHVIAACL-TESGS-TALKAETSERLRTVL---LDV 84
Query: 102 SDTKSIRAFAKGFLAE--EKHLHVLINNAGV--MMCPYS-KTADGFEMHIGVNHLGHFLL 156
+D ++++ A+ + EK L LINNAGV ++ P T + + I VN G +
Sbjct: 85 TDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISV 144
Query: 157 THLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANILFTQEL 216
T +L +K+ A R++NVSS+ L + G Y SK A F L
Sbjct: 145 TLNMLPLVKK-AQGRVINVSSVGGRLAIV-------------GGGYTPSKYAVEGFNDSL 190
Query: 217 ARRLKGSGVTTYSVHPGTVQSEL 239
R +K GV + PG ++ L
Sbjct: 191 RRDMKAFGVHVSCIEPGLFKTNL 213
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.136 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,354,697
Number of Sequences: 37866
Number of extensions: 466895
Number of successful extensions: 1168
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 62
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 1052
Number of HSP's gapped (non-prelim): 82
length of query: 318
length of database: 18,247,518
effective HSP length: 102
effective length of query: 216
effective length of database: 14,385,186
effective search space: 3107200176
effective search space used: 3107200176
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.