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Search of human proteins with 163644325
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|163644325 MCF.2 cell line derived transforming sequence-like
isoform a [Homo sapiens]
(1182 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|163644325 MCF.2 cell line derived transforming sequence-like ... 2372 0.0
gi|163644323 MCF.2 cell line derived transforming sequence-like ... 2193 0.0
gi|153791628 MCF.2 cell line derived transforming sequence isofo... 845 0.0
gi|31742505 Rho family guanine-nucleotide exchange factor [Homo ... 826 0.0
gi|153791325 MCF.2 cell line derived transforming sequence isofo... 785 0.0
gi|45439359 triple functional domain (PTPRF interacting) [Homo s... 238 3e-62
gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens] 231 4e-60
gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens] 226 1e-58
gi|148529025 pleckstrin homology domain containing, family G (wi... 195 2e-49
gi|150417975 RhoA/RAC/CDC42 exchange factor isoform 1 [Homo sapi... 192 2e-48
gi|162287076 RhoA/RAC/CDC42 exchange factor isoform 3 [Homo sapi... 192 2e-48
gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens] 191 3e-48
gi|193211598 pleckstrin homology domain containing, family G (wi... 190 8e-48
gi|193211596 pleckstrin homology domain containing, family G (wi... 190 8e-48
gi|193211594 pleckstrin homology domain containing, family G (wi... 190 8e-48
gi|55742734 pleckstrin homology domain containing, family G (wit... 190 8e-48
gi|193211603 pleckstrin homology domain containing, family G (wi... 188 3e-47
gi|71274148 pleckstrin homology domain containing, family G (wit... 141 3e-33
gi|58331253 obscurin, cytoskeletal calmodulin and titin-interact... 128 4e-29
gi|148833506 obscurin, cytoskeletal calmodulin and titin-interac... 128 4e-29
gi|188528641 SEC14 and spectrin domains 1 [Homo sapiens] 122 2e-27
gi|50843837 hypothetical protein LOC55701 [Homo sapiens] 121 3e-27
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex... 119 2e-26
gi|23308553 spermatogenesis associated 13 [Homo sapiens] 114 5e-25
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [... 104 4e-22
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [... 104 4e-22
gi|47578117 DEP domain containing 2 isoform b [Homo sapiens] 94 8e-19
gi|47578115 DEP domain containing 2 isoform a [Homo sapiens] 94 8e-19
gi|55749621 pleckstrin homology domain containing, family G, mem... 92 2e-18
gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens] 88 4e-17
>gi|163644325 MCF.2 cell line derived transforming sequence-like
isoform a [Homo sapiens]
Length = 1182
Score = 2372 bits (6146), Expect = 0.0
Identities = 1182/1182 (100%), Positives = 1182/1182 (100%)
Query: 1 MARVESPVPAARASLTGSCVLGQAMPLRGGAGPSPASHGPTHGPSDPRTCLPGRGAGGMR 60
MARVESPVPAARASLTGSCVLGQAMPLRGGAGPSPASHGPTHGPSDPRTCLPGRGAGGMR
Sbjct: 1 MARVESPVPAARASLTGSCVLGQAMPLRGGAGPSPASHGPTHGPSDPRTCLPGRGAGGMR 60
Query: 61 PHGRGALGCCGLCSFYTCHGAAGDEIMHQDIVPLCAADIQDQLKKRFAYLSGGRGQDGSP 120
PHGRGALGCCGLCSFYTCHGAAGDEIMHQDIVPLCAADIQDQLKKRFAYLSGGRGQDGSP
Sbjct: 61 PHGRGALGCCGLCSFYTCHGAAGDEIMHQDIVPLCAADIQDQLKKRFAYLSGGRGQDGSP 120
Query: 121 VITFPDYPAFSEIPDKEFQNVMTYLTSIPSLQDAGIGFILVIDRRRDKWTSVKASVLRIA 180
VITFPDYPAFSEIPDKEFQNVMTYLTSIPSLQDAGIGFILVIDRRRDKWTSVKASVLRIA
Sbjct: 121 VITFPDYPAFSEIPDKEFQNVMTYLTSIPSLQDAGIGFILVIDRRRDKWTSVKASVLRIA 180
Query: 181 ASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRDDFKMKVPVIMLSSVPDLHGYIDKSQLT 240
ASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRDDFKMKVPVIMLSSVPDLHGYIDKSQLT
Sbjct: 181 ASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRDDFKMKVPVIMLSSVPDLHGYIDKSQLT 240
Query: 241 EDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQMLQSFGTELAETELPNDVQSTSSVLCA 300
EDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQMLQSFGTELAETELPNDVQSTSSVLCA
Sbjct: 241 EDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQMLQSFGTELAETELPNDVQSTSSVLCA 300
Query: 301 HTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATVQRLLAQLNETE 360
HTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATVQRLLAQLNETE
Sbjct: 301 HTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATVQRLLAQLNETE 360
Query: 361 AAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILDAASQKIATFTDIGNSLAHVEHLLRD 420
AAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILDAASQKIATFTDIGNSLAHVEHLLRD
Sbjct: 361 AAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILDAASQKIATFTDIGNSLAHVEHLLRD 420
Query: 421 LASFEEKSGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGL 480
LASFEEKSGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGL
Sbjct: 421 LASFEEKSGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGL 480
Query: 481 LSKSLELHRRLETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQE 540
LSKSLELHRRLETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQE
Sbjct: 481 LSKSLELHRRLETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQE 540
Query: 541 LNAIYKEYESILNQDLMEHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPVAPRPE 600
LNAIYKEYESILNQDLMEHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPVAPRPE
Sbjct: 541 LNAIYKEYESILNQDLMEHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPVAPRPE 600
Query: 601 ALAKSPCPSPGIRRGSENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRR 660
ALAKSPCPSPGIRRGSENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRR
Sbjct: 601 ALAKSPCPSPGIRRGSENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRR 660
Query: 661 HVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHN 720
HVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHN
Sbjct: 661 HVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHN 720
Query: 721 RIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRK 780
RIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRK
Sbjct: 721 RIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRK 780
Query: 781 LDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEALSSILGILKAVNDSMH 840
LDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEALSSILGILKAVNDSMH
Sbjct: 781 LDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEALSSILGILKAVNDSMH 840
Query: 841 LIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCK 900
LIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCK
Sbjct: 841 LIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCK 900
Query: 901 KREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNAREEVYIVQAPTPEIK 960
KREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNAREEVYIVQAPTPEIK
Sbjct: 901 KREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNAREEVYIVQAPTPEIK 960
Query: 961 AAWVNEIRKVLTSQLQACREASQHRALEQSQSLPLPAPTSTSPSRGNSRNIKKLEERKTD 1020
AAWVNEIRKVLTSQLQACREASQHRALEQSQSLPLPAPTSTSPSRGNSRNIKKLEERKTD
Sbjct: 961 AAWVNEIRKVLTSQLQACREASQHRALEQSQSLPLPAPTSTSPSRGNSRNIKKLEERKTD 1020
Query: 1021 PLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPEDDGGWSSAEEQINSSDAEEDGGLGPK 1080
PLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPEDDGGWSSAEEQINSSDAEEDGGLGPK
Sbjct: 1021 PLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPEDDGGWSSAEEQINSSDAEEDGGLGPK 1080
Query: 1081 KLVPGKYTVVADHEKGGPDALRVRSGDVVELVQEGDEGLWYVRDPTTGKEGWVPASSLSV 1140
KLVPGKYTVVADHEKGGPDALRVRSGDVVELVQEGDEGLWYVRDPTTGKEGWVPASSLSV
Sbjct: 1081 KLVPGKYTVVADHEKGGPDALRVRSGDVVELVQEGDEGLWYVRDPTTGKEGWVPASSLSV 1140
Query: 1141 RLGPSGSAQCLSSSESSPGSAVLSNSSSCSEGGQAPFSDLQG 1182
RLGPSGSAQCLSSSESSPGSAVLSNSSSCSEGGQAPFSDLQG
Sbjct: 1141 RLGPSGSAQCLSSSESSPGSAVLSNSSSCSEGGQAPFSDLQG 1182
>gi|163644323 MCF.2 cell line derived transforming sequence-like
isoform b [Homo sapiens]
Length = 1129
Score = 2193 bits (5682), Expect = 0.0
Identities = 1102/1107 (99%), Positives = 1102/1107 (99%), Gaps = 4/1107 (0%)
Query: 80 GAAG----DEIMHQDIVPLCAADIQDQLKKRFAYLSGGRGQDGSPVITFPDYPAFSEIPD 135
G AG DEIMHQDIVPLCAADIQDQLKKRFAYLSGGRGQDGSPVITFPDYPAFSEIPD
Sbjct: 23 GTAGRSRPDEIMHQDIVPLCAADIQDQLKKRFAYLSGGRGQDGSPVITFPDYPAFSEIPD 82
Query: 136 KEFQNVMTYLTSIPSLQDAGIGFILVIDRRRDKWTSVKASVLRIAASFPANLQLVLVLRP 195
KEFQNVMTYLTSIPSLQDAGIGFILVIDRRRDKWTSVKASVLRIAASFPANLQLVLVLRP
Sbjct: 83 KEFQNVMTYLTSIPSLQDAGIGFILVIDRRRDKWTSVKASVLRIAASFPANLQLVLVLRP 142
Query: 196 TGFFQRTLSDIAFKFNRDDFKMKVPVIMLSSVPDLHGYIDKSQLTEDLGGTLDYCHSRWL 255
TGFFQRTLSDIAFKFNRDDFKMKVPVIMLSSVPDLHGYIDKSQLTEDLGGTLDYCHSRWL
Sbjct: 143 TGFFQRTLSDIAFKFNRDDFKMKVPVIMLSSVPDLHGYIDKSQLTEDLGGTLDYCHSRWL 202
Query: 256 CQRTAIESFALMVKQTAQMLQSFGTELAETELPNDVQSTSSVLCAHTEKKDKAKEDLRLA 315
CQRTAIESFALMVKQTAQMLQSFGTELAETELPNDVQSTSSVLCAHTEKKDKAKEDLRLA
Sbjct: 203 CQRTAIESFALMVKQTAQMLQSFGTELAETELPNDVQSTSSVLCAHTEKKDKAKEDLRLA 262
Query: 316 LKEGHSVLESLRELQAEGSEPSVNQDQLDNQATVQRLLAQLNETEAAFDEFWAKHQQKLE 375
LKEGHSVLESLRELQAEGSEPSVNQDQLDNQATVQRLLAQLNETEAAFDEFWAKHQQKLE
Sbjct: 263 LKEGHSVLESLRELQAEGSEPSVNQDQLDNQATVQRLLAQLNETEAAFDEFWAKHQQKLE 322
Query: 376 QCLQLRHFEQGFREVKAILDAASQKIATFTDIGNSLAHVEHLLRDLASFEEKSGVAVERA 435
QCLQLRHFEQGFREVKAILDAASQKIATFTDIGNSLAHVEHLLRDLASFEEKSGVAVERA
Sbjct: 323 QCLQLRHFEQGFREVKAILDAASQKIATFTDIGNSLAHVEHLLRDLASFEEKSGVAVERA 382
Query: 436 RALSLDGEQLIGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSM 495
RALSLDGEQLIGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSM
Sbjct: 383 RALSLDGEQLIGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSM 442
Query: 496 KWCDEGIYLLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQELNAIYKEYESILNQD 555
KWCDEGIYLLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQELNAIYKEYESILNQD
Sbjct: 443 KWCDEGIYLLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQELNAIYKEYESILNQD 502
Query: 556 LMEHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPVAPRPEALAKSPCPSPGIRRG 615
LMEHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPVAPRPEALAKSPCPSPGIRRG
Sbjct: 503 LMEHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPVAPRPEALAKSPCPSPGIRRG 562
Query: 616 SENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRRHVMSELLDTERAYVE 675
SENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRRHVMSELLDTERAYVE
Sbjct: 563 SENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRRHVMSELLDTERAYVE 622
Query: 676 ELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENYTDCPE 735
ELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENYTDCPE
Sbjct: 623 ELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENYTDCPE 682
Query: 736 LVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRKLDHKLSLDSYLLKPV 795
LVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRKLDHKLSLDSYLLKPV
Sbjct: 683 LVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRKLDHKLSLDSYLLKPV 742
Query: 796 QRITKYQLLLKEMLKYSRNCEGAEDLQEALSSILGILKAVNDSMHLIAITGYDGNLGDLG 855
QRITKYQLLLKEMLKYSRNCEGAEDLQEALSSILGILKAVNDSMHLIAITGYDGNLGDLG
Sbjct: 743 QRITKYQLLLKEMLKYSRNCEGAEDLQEALSSILGILKAVNDSMHLIAITGYDGNLGDLG 802
Query: 856 KLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSY 915
KLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSY
Sbjct: 803 KLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSY 862
Query: 916 SYKQSLNMAAVGITENVKGDAKKFEIWYNAREEVYIVQAPTPEIKAAWVNEIRKVLTSQL 975
SYKQSLNMAAVGITENVKGDAKKFEIWYNAREEVYIVQAPTPEIKAAWVNEIRKVLTSQL
Sbjct: 863 SYKQSLNMAAVGITENVKGDAKKFEIWYNAREEVYIVQAPTPEIKAAWVNEIRKVLTSQL 922
Query: 976 QACREASQHRALEQSQSLPLPAPTSTSPSRGNSRNIKKLEERKTDPLSLEGYVSSAPLTK 1035
QACREASQHRALEQSQSLPLPAPTSTSPSRGNSRNIKKLEERKTDPLSLEGYVSSAPLTK
Sbjct: 923 QACREASQHRALEQSQSLPLPAPTSTSPSRGNSRNIKKLEERKTDPLSLEGYVSSAPLTK 982
Query: 1036 PPEKGKGWSKTSHSLEAPEDDGGWSSAEEQINSSDAEEDGGLGPKKLVPGKYTVVADHEK 1095
PPEKGKGWSKTSHSLEAPEDDGGWSSAEEQINSSDAEEDGGLGPKKLVPGKYTVVADHEK
Sbjct: 983 PPEKGKGWSKTSHSLEAPEDDGGWSSAEEQINSSDAEEDGGLGPKKLVPGKYTVVADHEK 1042
Query: 1096 GGPDALRVRSGDVVELVQEGDEGLWYVRDPTTGKEGWVPASSLSVRLGPSGSAQCLSSSE 1155
GGPDALRVRSGDVVELVQEGDEGLWYVRDPTTGKEGWVPASSLSVRLGPSGSAQCLSSSE
Sbjct: 1043 GGPDALRVRSGDVVELVQEGDEGLWYVRDPTTGKEGWVPASSLSVRLGPSGSAQCLSSSE 1102
Query: 1156 SSPGSAVLSNSSSCSEGGQAPFSDLQG 1182
SSPGSAVLSNSSSCSEGGQAPFSDLQG
Sbjct: 1103 SSPGSAVLSNSSSCSEGGQAPFSDLQG 1129
>gi|153791628 MCF.2 cell line derived transforming sequence isoform a
[Homo sapiens]
Length = 985
Score = 845 bits (2184), Expect = 0.0
Identities = 450/959 (46%), Positives = 611/959 (63%), Gaps = 11/959 (1%)
Query: 108 AYLSGGRGQDGSPVITFPDYPAFSEIPDKEFQNVMTYLTSIPSLQDAGIGFILVIDRRRD 167
A+LSGGRG+D + +ITFP+ F IP++ V+TYLTSI + F +++DRR D
Sbjct: 5 AFLSGGRGKDNAWIITFPENCNFRCIPEEVIAKVLTYLTSIARQNGSDSRFTIILDRRLD 64
Query: 168 KWTSVKASVLRIAASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRDDFKMKVPVIMLSSV 227
W+S+K S+ +I+ASFP NL LVLVLRPT F QRT +DI F F+++DF +K+PV+MLSSV
Sbjct: 65 TWSSLKISLQKISASFPGNLHLVLVLRPTSFLQRTFTDIGFWFSQEDFMLKLPVVMLSSV 124
Query: 228 PDLHGYIDKSQLTEDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQMLQSFGTELAETEL 287
DL YID QLT +LGGTL YCHS W+ R AIE+FAL VK+ AQMLQSFGTELAETEL
Sbjct: 125 SDLLTYIDDKQLTPELGGTLQYCHSEWIIFRNAIENFALTVKEMAQMLQSFGTELAETEL 184
Query: 288 PNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPS---VNQDQLD 344
P+D+ S +L E+ K D+ KEG +L +L EG+ S ++
Sbjct: 185 PDDIPSIEEILAIRAERYHLLKNDITAVTKEGKILLTNLEVPDTEGAVSSRLECHRQISG 244
Query: 345 NQATVQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILDAASQKIATF 404
+ T+ +LL Q+++ E AFD FW KHQ K+EQ LQL FEQ F+++ ++ + A
Sbjct: 245 DWQTINKLLTQVHDMETAFDGFWEKHQLKMEQYLQLWKFEQDFQQLVTEVEFLLNQQAEL 304
Query: 405 TDIGNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELR 464
D+ ++A V+ ++ L + +E S + +A+ + L G +L N HYA+D I +C ELR
Sbjct: 305 ADVTGTIAQVKQKIKKLENLDENSQELLSKAQFVILHGHKLAANHHYALDLICQRCNELR 364
Query: 465 HLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQ 524
+L D EI +R LS++ ++H+ L+ + + CDEG LLA+Q +DK QS++ A+ ALQ
Sbjct: 365 YLSDILVNEIKAKRIQLSRTFKMHKLLQQARQCCDEGECLLANQEIDKFQSKEDAQKALQ 424
Query: 525 EIEKFLETGAENKIQELNAIYKEYESILNQDLMEHVRKVFQKQASMEEVFHRRQASLKKL 584
+IE FLE E + E++ IL+ +L ++ + K ++ +F +QA + L
Sbjct: 425 DIENFLEMALPFINYEPETLQYEFDVILSPELKVQMKTIQLKLENIRSIFENQQAGFRNL 484
Query: 585 AARQTRPVQPVAPRPEALAKSPCPSPGIRRGSENSSSEGGALRRGPYRRAKSEMSESRQG 644
A + RP+Q V P PE L S P ++G + L+ + + S G
Sbjct: 485 ADKHVRPIQFVVPTPENLVTSGTPFFSSKQGKKTWRQNQSNLKIEVVPDCQEKRSS---G 541
Query: 645 RGSAGEEEESLAILRRHVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNK 704
S+ + SL +L+ HV++EL+ TER YV EL VL GY AEMDNP M L+ L NK
Sbjct: 542 PSSSLDNGNSLDVLKNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNK 601
Query: 705 KDVLFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESL 764
KD+LFGNM EIY FHN IFL LEN PE VG CFLER +DFQ+Y KYCQNKPRSE++
Sbjct: 602 KDILFGNMAEIYEFHNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETI 661
Query: 765 WRQCSDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEA 824
WR+ S+C FFQECQRKL H+L LDSYLLKPVQRITKYQLLLKE+LKYS++CEG+ L++A
Sbjct: 662 WRKYSECAFFQECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGSALLKKA 721
Query: 825 LSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKP 884
L ++L +LK+VNDSMH IAI GY GNL +LGK++MQG FSVW HK+G TK+K+LARFKP
Sbjct: 722 LDAMLDLLKSVNDSMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKP 781
Query: 885 MQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYN 944
MQRHLFL+EKA++FCK+R E+GEG ++ PSYS+K M VGITE VKGD +KFEIWY
Sbjct: 782 MQRHLFLYEKAIVFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYG 841
Query: 945 AREEVYIVQAPTPEIKAAWVNEIRKVLTSQ--LQACREASQHRALEQSQSLPLPAPTSTS 1002
+EEVYIVQA ++K W+ EIR +L Q L ++ Q L + + +
Sbjct: 842 EKEEVYIVQASNVDVKMTWLKEIRNILLKQQELLTVKKRKQQDQLTERDKFQISLQQNDE 901
Query: 1003 PSRGNSRNIKKLEERKTDPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPEDDGGWSS 1061
+G EE + + S V A + E W++ S S E E+ WSS
Sbjct: 902 KQQG---AFISTEETELEHTSTVVEVCEAIASVQAEANTVWTEASQSAEISEEPAEWSS 957
>gi|31742505 Rho family guanine-nucleotide exchange factor [Homo
sapiens]
Length = 1114
Score = 826 bits (2133), Expect = 0.0
Identities = 447/988 (45%), Positives = 629/988 (63%), Gaps = 56/988 (5%)
Query: 84 DEIMHQDIVPLCAADIQDQLKKRFAYLSGGRGQDGSPVITFPDYPAFSEIPDKEFQNVMT 143
DEIM Q++ PL A +I +QL ++FA LSGGRG+DG+P+ITFP++ F IPD++F NVMT
Sbjct: 26 DEIMQQEVRPLMAVEIIEQLHRQFAILSGGRGEDGAPIITFPEFSGFKHIPDEDFLNVMT 85
Query: 144 YLTSIPSLQDAGIGFILVIDRRRDKWTSVKASVLRIAASFPANLQLVLVLRPTGFFQRTL 203
YLTSIPS++ A IGFI+VIDRRRDKW+SVKAS+ RIA +FP NLQL+ +LRP+ F QRT
Sbjct: 86 YLTSIPSVEAASIGFIVVIDRRRDKWSSVKASLTRIAVAFPGNLQLIFILRPSRFIQRTF 145
Query: 204 SDIAFKFNRDDFKMKVPVIMLSSVPDLHGYIDKSQLTEDLGGTLDYCHSRWLCQRTAIES 263
+DI K+ R++FK KVP+IM++SV DLHGYIDKSQLT +LGGTL+Y H +W+ RTAIE+
Sbjct: 146 TDIGIKYYRNEFKTKVPIIMVNSVSDLHGYIDKSQLTRELGGTLEYRHGQWVNHRTAIEN 205
Query: 264 FALMVKQTAQMLQSFGTELAETELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVL 323
FAL +K TAQMLQ+FG+ LA ELP + ST +L +HT ++DK +++L+L K+G ++L
Sbjct: 206 FALTLKTTAQMLQTFGSCLATAELPRSMLSTEDLLMSHTRQRDKLQDELKLLGKQGTTLL 265
Query: 324 ESLRELQAEGSEPSVNQDQLDNQATVQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHF 383
++E + +N +QL+N T++RLL QL+ETE AF FW++H KL QCLQL+HF
Sbjct: 266 SCIQEPATKCPNSKLNLNQLENVTTMERLLVQLDETEKAFSHFWSEHHLKLNQCLQLQHF 325
Query: 384 EQGFREVKAILDAASQKIATFTDIGNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGE 443
E F + K LD ++ A FT IG+S+ HVE +L++ EEKS +E+A+ L+L G+
Sbjct: 326 EHDFCKAKLALDNLLEEQAEFTGIGDSVMHVEQILKEHKKLEEKSQEPLEKAQLLALVGD 385
Query: 444 QLIGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCDEGIY 503
QLI + HYA D+IRP+C ELRHLCD F ++ +L KSLE HR+L+ +WC+ GIY
Sbjct: 386 QLIQSHHYAADAIRPRCVELRHLCDDFINGNKKKWDILGKSLEFHRQLDKVSQWCEAGIY 445
Query: 504 LLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQELNAIYKEYESILNQDLMEHVRKV 563
LLASQ VDKCQS++G + AL +I FL T E + Y E+E +L D +KV
Sbjct: 446 LLASQAVDKCQSREGVDIALNDIATFLGTVKEYPLLSPKEFYNEFELLLTLDAKAKAQKV 505
Query: 564 FQKQASMEEVFHRRQASLKKLAARQTRPVQPVAPRPEA-----LAKSPCPSPGI-----R 613
Q+ ++E+FH+RQ SL KLAA+QTRPVQPVAP PE+ +K+ PS +
Sbjct: 506 LQRLDDVQEIFHKRQVSLMKLAAKQTRPVQPVAPHPESSPKWVSSKTSQPSTSVPLARPL 565
Query: 614 RGSENSSSEGGALRRG------PYRRAKSEMSESRQGRGSAG-EEEESLAIL--RRHVMS 664
R SE +E RG + E+ ES RG+ E++ L L RR ++
Sbjct: 566 RTSEEPYTETELNSRGKEDDETKFEVKSEEIFESHHERGNPELEQQARLGDLSPRRRIIR 625
Query: 665 ELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRIFL 724
+LL+TE Y++E+ +++GY MD + HL+ L N KD LFGN+ E+Y FHNR FL
Sbjct: 626 DLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPDVLQNNKDFLFGNIRELYEFHNRTFL 685
Query: 725 RELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRKLDHK 784
+ELE + PEL+ CFL+R ED QIY KY +N PR+ ++W++C DC +F CQR+LDH
Sbjct: 686 KELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLPRARAIWQECQDCAYFGVCQRQLDHN 745
Query: 785 LSLDSYLLKPVQRITKYQLLLKEML-----------------------KYSRNCEGAEDL 821
L L YL P QR+ KYQ+LLK +L K +++ + +L
Sbjct: 746 LPLFKYLKGPSQRLIKYQMLLKGLLDFESPEDMEIDPGELGGSAKDGPKRTKDSAFSTEL 805
Query: 822 QEALSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELAR 881
Q+AL+ I ++K+ ++ L A+T ++G LGKLL+ G FSVWT HK + K+K+L R
Sbjct: 806 QQALAVIEDLIKSCELAVDLAAVTECPDDIGKLGKLLLHGPFSVWTIHKDRY-KMKDLIR 864
Query: 882 FKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEI 941
FKP QR ++L E+ ++FCK R E G+ +P YS+K+++ + + I + +G +KFEI
Sbjct: 865 FKPSQRQIYLFERGIVFCKIRMEPGD-QGLSPHYSFKKTMKLMTLSIRQLGRGSHRKFEI 923
Query: 942 WYNAREEVYIVQAPTPEIKAAWVNEIRKVLTSQLQACREASQHRALEQSQSLPLPAPTST 1001
E YI+QA + EI+ W +EI K+L Q ++ + E S TS
Sbjct: 924 ASRNGLEKYILQAASKEIRDCWFSEISKLLMEQQNNIKDQGNPQ-FEMS--------TSK 974
Query: 1002 SPSRGNSRNIKKLEE---RKTDPLSLEG 1026
G+ IK +E K DP S G
Sbjct: 975 GSGAGSGPWIKNMERATTSKEDPASSTG 1002
>gi|153791325 MCF.2 cell line derived transforming sequence isoform b
[Homo sapiens]
Length = 925
Score = 785 bits (2028), Expect = 0.0
Identities = 420/889 (47%), Positives = 564/889 (63%), Gaps = 11/889 (1%)
Query: 178 RIAASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRDDFKMKVPVIMLSSVPDLHGYIDKS 237
R AASFP NL LVLVLRPT F QRT +DI F F+++DF +K+PV+MLSSV DL YID
Sbjct: 15 RNAASFPGNLHLVLVLRPTSFLQRTFTDIGFWFSQEDFMLKLPVVMLSSVSDLLTYIDDK 74
Query: 238 QLTEDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQMLQSFGTELAETELPNDVQSTSSV 297
QLT +LGGTL YCHS W+ R AIE+FAL VK+ AQMLQSFGTELAETELP+D+ S +
Sbjct: 75 QLTPELGGTLQYCHSEWIIFRNAIENFALTVKEMAQMLQSFGTELAETELPDDIPSIEEI 134
Query: 298 LCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPS---VNQDQLDNQATVQRLLA 354
L E+ K D+ KEG +L +L EG+ S ++ + T+ +LL
Sbjct: 135 LAIRAERYHLLKNDITAVTKEGKILLTNLEVPDTEGAVSSRLECHRQISGDWQTINKLLT 194
Query: 355 QLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILDAASQKIATFTDIGNSLAHV 414
Q+++ E AFD FW KHQ K+EQ LQL FEQ F+++ ++ + A D+ ++A V
Sbjct: 195 QVHDMETAFDGFWEKHQLKMEQYLQLWKFEQDFQQLVTEVEFLLNQQAELADVTGTIAQV 254
Query: 415 EHLLRDLASFEEKSGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRHLCDQFSAEI 474
+ ++ L + +E S + +A+ + L G +L N HYA+D I +C ELR+L D EI
Sbjct: 255 KQKIKKLENLDENSQELLSKAQFVILHGHKLAANHHYALDLICQRCNELRYLSDILVNEI 314
Query: 475 ARRRGLLSKSLELHRRLETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQEIEKFLETGA 534
+R LS++ ++H+ L+ + + CDEG LLA+Q +DK QS++ A+ ALQ+IE FLE
Sbjct: 315 KAKRIQLSRTFKMHKLLQQARQCCDEGECLLANQEIDKFQSKEDAQKALQDIENFLEMAL 374
Query: 535 ENKIQELNAIYKEYESILNQDLMEHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQP 594
E + E++ IL+ +L ++ + K ++ +F +QA + LA + RP+Q
Sbjct: 375 PFINYEPETLQYEFDVILSPELKVQMKTIQLKLENIRSIFENQQAGFRNLADKHVRPIQF 434
Query: 595 VAPRPEALAKSPCPSPGIRRGSENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEES 654
V P PE L S P ++G + L+ + + S G S+ + S
Sbjct: 435 VVPTPENLVTSGTPFFSSKQGKKTWRQNQSNLKIEVVPDCQEKRSS---GPSSSLDNGNS 491
Query: 655 LAILRRHVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEE 714
L +L+ HV++EL+ TER YV EL VL GY AEMDNP M L+ L NKKD+LFGNM E
Sbjct: 492 LDVLKNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAE 551
Query: 715 IYHFHNRIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPFF 774
IY FHN IFL LEN PE VG CFLER +DFQ+Y KYCQNKPRSE++WR+ S+C FF
Sbjct: 552 IYEFHNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSECAFF 611
Query: 775 QECQRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEALSSILGILKA 834
QECQRKL H+L LDSYLLKPVQRITKYQLLLKE+LKYS++CEG+ L++AL ++L +LK+
Sbjct: 612 QECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGSALLKKALDAMLDLLKS 671
Query: 835 VNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEK 894
VNDSMH IAI GY GNL +LGK++MQG FSVW HK+G TK+K+LARFKPMQRHLFL+EK
Sbjct: 672 VNDSMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEK 731
Query: 895 AVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNAREEVYIVQA 954
A++FCK+R E+GEG ++ PSYS+K M VGITE VKGD +KFEIWY +EEVYIVQA
Sbjct: 732 AIVFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYGEKEEVYIVQA 791
Query: 955 PTPEIKAAWVNEIRKVLTSQ--LQACREASQHRALEQSQSLPLPAPTSTSPSRGNSRNIK 1012
++K W+ EIR +L Q L ++ Q L + + + +G
Sbjct: 792 SNVDVKMTWLKEIRNILLKQQELLTVKKRKQQDQLTERDKFQISLQQNDEKQQG---AFI 848
Query: 1013 KLEERKTDPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPEDDGGWSS 1061
EE + + S V A + E W++ S S E E+ WSS
Sbjct: 849 STEETELEHTSTVVEVCEAIASVQAEANTVWTEASQSAEISEEPAEWSS 897
>gi|45439359 triple functional domain (PTPRF interacting) [Homo
sapiens]
Length = 3097
Score = 238 bits (607), Expect = 3e-62
Identities = 210/691 (30%), Positives = 326/691 (47%), Gaps = 94/691 (13%)
Query: 503 YLLASQPVDKCQS----QDGAEAALQEI----EKFLETGAE--NKIQELNAIYKEYES-- 550
+ + + +D+CQ + A+ AL+ I E +L T + IQ + KE+E
Sbjct: 1127 WTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGSSIQHTQELLKEHEEFQ 1186
Query: 551 ILNQDLMEHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPVAPRPEALAKSPCPSP 610
I + E V+ + Q E H A +KK + + + R E S +
Sbjct: 1187 ITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKAL 1246
Query: 611 GIRRGSENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRRHVMSELLDTE 670
GI S N SS+ L P SE+ + R EE+ A + +M+EL+ TE
Sbjct: 1247 GISSDS-NKSSKSLQLDIIPASIPGSEV-KLRDAAHELNEEKRKSARRKEFIMAELIQTE 1304
Query: 671 RAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENY 730
+AYV +L ++ Y EM + + + G+ NK+ ++FGNM+EIY FHN IFL+ELE Y
Sbjct: 1305 KAYVRDLRECMDTYLWEMTSGVEE--IPPGIVNKELIIFGNMQEIYEFHNNIFLKELEKY 1362
Query: 731 TDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRKLDHKLSLDSY 790
PE VG CF+ + FQ+Y YC+NKP S L + + +F E Q++ S+ SY
Sbjct: 1363 EQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAG-SYFDEIQQRHGLANSISSY 1421
Query: 791 LLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEALSSILGILKAVNDSMHLIAITGYDGN 850
L+KPVQRITKYQLLLKE+L EG ++++ L +L + K ND+MHL + G+D N
Sbjct: 1422 LIKPVQRITKYQLLLKELLTCCE--EGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDEN 1479
Query: 851 LGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYE 910
+ G+L++Q SF VW K L R K +RHLFL E +++F K+ +++ G
Sbjct: 1480 IESQGELILQESFQVWDP--------KTLIR-KGRERHLFLFEMSLVFSKEVKDS-SGRS 1529
Query: 911 KAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYN---AREEVYIVQAPTPEIKAAWVNEI 967
K Y YK L + +G+TE+V+GD KF +W + +++A + E K W+ I
Sbjct: 1530 K---YLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHI 1586
Query: 968 RKVLTSQLQACREASQHRALEQSQSLPLPAPTSTSPSRGNSRNIKKLEERKTDPLSLEGY 1027
R+V+ R AL++ +P AP + R R + L +G
Sbjct: 1587 REVIQE-----RTIHLKGALKEPIHIPKTAPATRQKGR-----------RDGEDLDSQGD 1630
Query: 1028 VSSAPLTKPPEKGKGWSKTSHSLEAPEDDGGWSSAEEQINSSDAEEDGGLGPKKLVPGKY 1087
SS P T S+TS N+ D+++ G +V +
Sbjct: 1631 GSSQPDTISIA-----SRTSQ------------------NTLDSDKLSGGCELTVVIHDF 1667
Query: 1088 TVVADHEKGGPDALRVRSGDVVELVQ----EGDEGLWYVRDPTTGKEGWVPASSLSVRLG 1143
T +E L +R G VE+++ + D L D + EG VP SL +
Sbjct: 1668 TACNSNE------LTIRRGQTVEVLERPHDKPDWCLVRTTDRSPAAEGLVPCGSLCIAHS 1721
Query: 1144 PSG----------SAQCLSSSESSPGSAVLS 1164
S + +SS+++SP ++V S
Sbjct: 1722 RSSMEMEGIFNHKDSLSVSSNDASPPASVAS 1752
Score = 188 bits (478), Expect = 2e-47
Identities = 115/329 (34%), Positives = 191/329 (58%), Gaps = 19/329 (5%)
Query: 650 EEEESLAILRRH-VMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVL 708
EE +S ++ RRH V+ EL++TER YV +L V+EGY A M + + K ++
Sbjct: 1960 EERKSSSLKRRHYVLQELVETERDYVRDLGYVVEGYMALMKEDGVPD----DMKGKDKIV 2015
Query: 709 FGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQC 768
FGN+ +IY +H FL ELE + PE +G F++ +Y YCQNKP+SE + +
Sbjct: 2016 FGNIHQIYDWHRDFFLGELEKCLEDPEKLGSLFVKHERRLHMYIAYCQNKPKSEHIVSEY 2075
Query: 769 SDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCE-GAEDLQEALSS 827
D FF++ +++L H+L L L+KPVQRI KYQLLLK+ LKYS+ +L+ A+
Sbjct: 2076 ID-TFFEDLKQRLGHRLQLTDLLIKPVQRIMKYQLLLKDFLKYSKKASLDTSELERAVEV 2134
Query: 828 ILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQR 887
+ + + ND M++ + G+DG + GKLL+Q +F V TD G L R + +R
Sbjct: 2135 MCIVPRRCNDMMNVGRLQGFDGKIVAQGKLLLQDTFLV-TDQDAG-----LLPRCR--ER 2186
Query: 888 HLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNARE 947
+FL E+ V+F + ++ +G+ P + +K S+ ++ + + ENV+ D KF + +
Sbjct: 2187 RIFLFEQIVIFSEPLDKK-KGF-SMPGFLFKNSIKVSCLCLEENVENDPCKFALTSRTGD 2244
Query: 948 --EVYIVQAPTPEIKAAWVNEIRKVLTSQ 974
E +I+ + +P ++ W++EI ++L +Q
Sbjct: 2245 VVETFILHSSSPSVRQTWIHEINQILENQ 2273
Score = 180 bits (456), Expect = 8e-45
Identities = 155/591 (26%), Positives = 258/591 (43%), Gaps = 72/591 (12%)
Query: 29 GGAGPSPASHGPTHGPSDPRTCLPGRGAGGMRPHG--RGALGCCGLCSFYTCHGAAGDEI 86
GGA AS GP S G G GG G A + +F+ DE+
Sbjct: 6 GGAAAPAASSGPAAAAS-----AAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEM 60
Query: 87 MHQDIVPLCAADIQDQLKKRFAYLSGGRGQDGSPVITFPDYPAFSEIPDKEFQNVMTYLT 146
D++P+ LK++ AYLSGGR + G P++TFP I ++ + +++YL
Sbjct: 61 KAMDVLPI--------LKEKVAYLSGGRDKRGGPILTFPARSNHDRIRQEDLRRLISYLA 112
Query: 147 SIPSLQDAGIGFILVIDRRRDKWTSVKASVLRIAASFPANLQLVLVLRPTGFFQRTLSDI 206
IPS + GF +++D R KW S+K + + SFP + + L+++P F+Q+ ++
Sbjct: 113 CIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTN- 171
Query: 207 AFKFNRDDFKMKVPVIMLSSVPDLHGYIDKSQLTEDLGGTLDYCHSRWLCQRTAIESFAL 266
F F+ + ++ L + + +D SQLT + G L+Y H W+ R A E +
Sbjct: 172 ---FGSSKFEFETNMVSLEGLTKV---VDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYIS 225
Query: 267 MVKQTAQMLQSFGTELAETELPNDVQSTSSVLCAHTEKKDKA----KEDLRLALKEGHSV 322
L+ LA+ ELP D++ +++ H++ K K EDL L EG +
Sbjct: 226 NATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKAPIEDLDL---EGQKL 282
Query: 323 LESLRELQA--EGSEPSVNQDQLDNQATVQRLLAQLNETEAAFDEFWAKHQQKLEQCLQL 380
L+ ++ ++ + + S N D + V +L +L+ T + W + KL+QC QL
Sbjct: 283 LQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQL 342
Query: 381 RHFEQGFREV-KAILDAASQKIATFTDIGNSLAHVEHLLRDLASFEEK-SGVAVERARAL 438
R FEQ ++ I + ++T+IG S H L F V V R +
Sbjct: 343 RLFEQDAEKMFDWITHNKGLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIM 402
Query: 439 SLDGEQLIGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSM--- 495
S+ +L+ + HYA IR +L F+A + R LL S H++ E M
Sbjct: 403 SV-ANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIFHQKAEKYMSNV 461
Query: 496 -KWC---------------------DEGIY---LLASQPVDKCQSQDGAEAALQEIEKFL 530
WC +GIY LA V SQDG ++ L ++++ L
Sbjct: 462 DSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEV----SQDG-KSLLDKLQRPL 516
Query: 531 ETGAENKIQELNAIYKEYESILNQDLMEHVRKVFQKQASMEEVFHRRQASL 581
G+ + + K +L + + +V Q +E ++ R+ L
Sbjct: 517 TPGSSDSLTASANYSKAVHHVL-----DVIHEVLHHQRQLENIWQHRKVRL 562
Score = 64.7 bits (156), Expect = 5e-10
Identities = 74/336 (22%), Positives = 134/336 (39%), Gaps = 24/336 (7%)
Query: 275 LQSFGTELAETELPNDVQSTSSVLCAHTEKKDKAKEDLRLA---LKEGHSVLESLRELQA 331
L+S+ EL++ D + + DKA L + +G +L+ + E+QA
Sbjct: 802 LESWNDELSQQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQA 861
Query: 332 EGSEPSVNQDQLDNQATVQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFREVK 391
G E ++D +D VQ LL L+E + D +H++ LEQC+QLRH + ++V
Sbjct: 862 SGVELLCDRD-VDMATRVQDLLEFLHEKQQELDLAAEQHRKHLEQCVQLRHLQAEVKQVL 920
Query: 392 AILDAASQKIATFTDIGNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQLIGNKHY 451
+ + +SL E L R+ F+ + A + E ++ HY
Sbjct: 921 GWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHY 980
Query: 452 AVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCD--EGIYLLASQP 509
+D IR +++ Q ++ R L++ S+ ++ TS + C E + +
Sbjct: 981 DMDMIRDCAEKVASHWQQLMLKMEDRLKLVNASVAFYK---TSEQVCSVLESLEQEYKRE 1037
Query: 510 VDKCQSQD--GAEAALQEIEKFLETGAENKIQELNAI------------YKEYESILNQD 555
D C D G + + + E K L A Y S+
Sbjct: 1038 EDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRNADVFLKYLHRNSVNMPG 1097
Query: 556 LMEHVRKVFQKQAS-MEEVFHRRQASLKKLAARQTR 590
++ H++ Q+ + + E+F R L R+ R
Sbjct: 1098 MVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRR 1133
Score = 62.0 bits (149), Expect = 3e-09
Identities = 68/321 (21%), Positives = 129/321 (40%), Gaps = 29/321 (9%)
Query: 284 ETELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQL 343
E +LP+++Q + H + ++G S+L+ L+ GS S+
Sbjct: 470 EVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASAN 529
Query: 344 DNQATVQRLLAQLNET---EAAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILDAASQK 400
++A V +L ++E + + W + +L Q LQL F+Q ++V ++ +
Sbjct: 530 YSKA-VHHVLDVIHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEA 588
Query: 401 -IATFTDIGNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQLIGNKHYAVDSIRPK 459
++ T +G SL L + FEE + A L EQL + I
Sbjct: 589 FLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYQA 648
Query: 460 CQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCDEGIYLLASQPVDKCQSQDGA 519
+L F + +R+ LL S+ H ++ W +E L + +D ++ +
Sbjct: 649 AHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEE----LQKELLDDVYAE--S 702
Query: 520 EAALQEIEKFLETGAENKIQELNAIYKEYESILNQ--------------DLMEHVRKVFQ 565
A+Q++ K + +Q + KE E ++ Q + H+ V Q
Sbjct: 703 VEAVQDLIKRFGQQQQTTLQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQ 762
Query: 566 K----QASMEEVFHRRQASLK 582
+ Q+ MEE+F R+ L+
Sbjct: 763 QLDEAQSQMEELFQERKIKLE 783
Score = 48.1 bits (113), Expect = 5e-05
Identities = 50/241 (20%), Positives = 99/241 (41%), Gaps = 4/241 (1%)
Query: 289 NDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQAT 348
++ + ++ H E+K+ + LA + L+ L + P + +
Sbjct: 1051 SETDHVTPMISKHLEQKEAFLKACTLARRNADVFLKYLHRNSV--NMPGMVTHIKAPEQQ 1108
Query: 349 VQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFRE-VKAILDAASQKIATFTDI 407
V+ +L +L + E +W +++L+QC Q FE+ ++ ++ I D ++T T
Sbjct: 1109 VKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTST 1168
Query: 408 GNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRHLC 467
G+S+ H + LL++ F+ + ER + L + H I+ +
Sbjct: 1169 GSSIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRY 1228
Query: 468 DQFSAEIARRRGLLSKSLELHRRLETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQEIE 527
FS + + R L K+L + S K I + AS P + + +D A +E
Sbjct: 1229 RDFSLRMEKYRTSLEKALGISSDSNKSSKSLQLDI-IPASIPGSEVKLRDAAHELNEEKR 1287
Query: 528 K 528
K
Sbjct: 1288 K 1288
Score = 43.5 bits (101), Expect = 0.001
Identities = 32/140 (22%), Positives = 70/140 (50%), Gaps = 4/140 (2%)
Query: 263 SFALMVKQTAQMLQSFGTELAETELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSV 322
SF VK+ L+ EL + V++ ++ +++ + +KEG +
Sbjct: 675 SFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTTLQVTVNVIKEGEDL 734
Query: 323 LESLRELQAEGSEPSVNQDQLDNQATVQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRH 382
++ LR+ A S + + +++ TV L QL+E ++ +E + + + KLE LQLR
Sbjct: 735 IQQLRD-SAISSNKTPHNSSINHIETV---LQQLDEAQSQMEELFQERKIKLELFLQLRI 790
Query: 383 FEQGFREVKAILDAASQKIA 402
FE+ ++ + L++ + +++
Sbjct: 791 FERDAIDIISDLESWNDELS 810
>gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]
Length = 2986
Score = 231 bits (588), Expect = 4e-60
Identities = 199/676 (29%), Positives = 311/676 (46%), Gaps = 101/676 (14%)
Query: 503 YLLASQPVDKCQS----QDGAEAALQEIEKFLE------TGAENKIQELNAIYKEYES-- 550
+ L + +D+CQ + A+ AL I++ E T +E + KEY
Sbjct: 1119 WTLKKRRLDQCQQYVVFERSAKQALDWIQETGEFYLSTHTSTGETTEETQELLKEYGEFR 1178
Query: 551 ILNQDLMEHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPVAPRPEALAKSPCPSP 610
+ + E V+ + Q S E H ++K + + + R S +
Sbjct: 1179 VPAKQTKEKVKLLIQLADSFVEKGHIHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKAL 1238
Query: 611 GIRRGSENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRRHVMSELLDTE 670
G+ +N E + P + E+ + R EE+ A + +M+ELL TE
Sbjct: 1239 GVNT-EDNKDLELDII---PASLSDREV-KLRDANHEVNEEKRKSARKKEFIMAELLQTE 1293
Query: 671 RAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENY 730
+AYV +L LE Y EM + + + G+ NK+ ++FGN++EIY FHN IFL+ELE Y
Sbjct: 1294 KAYVRDLHECLETYLWEMTSGVEE--IPPGILNKEHIIFGNIQEIYDFHNNIFLKELEKY 1351
Query: 731 TDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRKLDHKLSLDSY 790
PE VG CF+ + FQ+Y YC+NKP S L + + FF E Q++ S+ SY
Sbjct: 1352 EQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAG-TFFDEIQQRHGLANSISSY 1410
Query: 791 LLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEALSSILGILKAVNDSMHLIAITGYDGN 850
L+KPVQRITKYQLLLKE+L EG +L++ L +L + K ND+MH+ + G+D N
Sbjct: 1411 LIKPVQRITKYQLLLKELLTCCE--EGKGELKDGLEVMLSVPKKANDAMHVSMLEGFDEN 1468
Query: 851 LGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYE 910
L G+L++Q +F VW K L R K +RHLFL E +++F K+ +++ G+
Sbjct: 1469 LDVQGELILQDAFQVWDP--------KSLIR-KGRERHLFLFEISLVFSKEIKDS-SGHT 1518
Query: 911 KAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYN---AREEVYIVQAPTPEIKAAWVNEI 967
K Y YK L + +G+TE+V+GD KF +W + + +++A E K W+ I
Sbjct: 1519 K---YVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETKQEWIKNI 1575
Query: 968 RKVLTSQLQACREASQHRALEQSQSLPLPAPTSTSPSRGNSRNIKKLEERKTDPLSLEGY 1027
R+V+ ++ + A + PL P + + R NS+
Sbjct: 1576 REVIQERIIHLKGALKE---------PLQLPKTPAKQRNNSKR----------------- 1609
Query: 1028 VSSAPLTKPPEKGKGWSKTSHSLEAPEDDGGWSSAEEQINSSDAEEDGGLGPKKLVPG-K 1086
+E + G SS + I+ + + KL G +
Sbjct: 1610 --------------------DGVEDIDSQGDGSSQPDTISIASRTSQNTVDSDKLSGGCE 1649
Query: 1087 YTVV-ADHEKGGPDALRVRSGDVVELVQEGDEGLWYVRDPTTGK----EGWVPASSLSVR 1141
TVV D G L ++ G VEL++ E + TT + EG VP+S+L
Sbjct: 1650 LTVVLQDFSAGHSSELTIQVGQTVELLERPSERPGWCLVRTTERSPPLEGLVPSSAL--- 1706
Query: 1142 LGPSGSAQCLSSSESS 1157
C+S S SS
Sbjct: 1707 --------CISHSRSS 1714
Score = 191 bits (486), Expect = 3e-48
Identities = 147/523 (28%), Positives = 250/523 (47%), Gaps = 60/523 (11%)
Query: 650 EEEESLAILRRH--VMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDV 707
EEE+ LR V++EL+ TE+ YV++L V+EG+ ++ + + K +
Sbjct: 1919 EEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPE----DMRGKDKI 1974
Query: 708 LFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQ 767
+FGN+ +IY +H FL ELE + + + F++ IY YCQNKPRSE + +
Sbjct: 1975 VFGNIHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAE 2034
Query: 768 CSDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAE--DLQEAL 825
+F+E +++++ +L+L +L+KP+QRITKYQLLLK+ L+YS G E D+++A+
Sbjct: 2035 YD--AYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKA-GLECSDIEKAV 2091
Query: 826 SSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPM 885
+ + K ND M+L + G++G L GKLL Q +F V ++ KE
Sbjct: 2092 ELMCLVPKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGMQSRTKE------- 2144
Query: 886 QRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNA 945
R +FL E+ V+F + + P Y +K+S+ M + + ENV D KF +
Sbjct: 2145 -RRVFLFEQIVIFSELLRKG----SLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRE 2199
Query: 946 REEVYIVQAPTPEIKAAWVNEIRKVLTSQ---LQACREASQHRALEQSQSLPLPAPTSTS 1002
E ++QA +I+ AWV +I +VL +Q L A + +++ E+S ++ P
Sbjct: 2200 TSERVVLQAANADIQQAWVQDINQVLETQRDFLNALQSPIEYQRKERSTAVMRSQPA--- 2256
Query: 1003 PSRGNSRNIKKLEERKTDPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPEDDGG---- 1058
+L + P Y S ++ P KG ++ L+ +G
Sbjct: 2257 ----------RLPQASPRP-----YSSVPAGSEKPPKGSSYNPPLPPLKISTSNGSPGFE 2301
Query: 1059 WSSAEEQINSSDAEEDGGLGPKKLVPGKYTVVADHEKGGPDALRVRSGDVVELVQEGDEG 1118
+ ++ +S + GG V+ D+ + + V G+VV+++ +
Sbjct: 2302 YHQPGDKFEASKQNDLGGCNG----TSSMAVIKDYYALKENEICVSQGEVVQVLAVNQQN 2357
Query: 1119 LWYVRDPTT----GKEGWVPASSLSVRLGPSGSAQCLSSSESS 1157
+ V P + EGWVP S L+ P A SS+ S
Sbjct: 2358 MCLVYQPASDHSPAAEGWVPGSILA----PLTKATAAESSDGS 2396
Score = 163 bits (412), Expect = 1e-39
Identities = 136/521 (26%), Positives = 230/521 (44%), Gaps = 51/521 (9%)
Query: 94 LCAADIQDQLKKRFAYLSGGRGQDGSPVITFPDYPAFSEIPDKEFQNVMTYLTSIPSLQD 153
L A+D+ LK++ A++SGGR + G P++TFP I ++ + ++TYL S+PS
Sbjct: 30 LKASDVLPILKEKVAFVSGGRDKRGGPILTFPARSNHDRIRQEDLRKLVTYLASVPSEDV 89
Query: 154 AGIGFILVIDRRRDKWTSVKASVLRIAASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRD 213
GF ++ID R KW +K + + +FPA + + L+++P F+Q+ ++ F
Sbjct: 90 CKRGFTVIIDMRGSKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKTN----FGSS 145
Query: 214 DFKMKVPVIMLSSVPDLHGYIDKSQLTEDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQ 273
F + ++ SV L +D SQLTE+ G+LDY H W+ R ++E F
Sbjct: 146 KFIFETSMV---SVEGLTKLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLS 202
Query: 274 MLQSFGTELAETELPNDVQSTSSVLCAHTEKKDKA-KEDLRLALKEGHSVLESLRELQAE 332
L+ LA E P DV+ + ++ HT+ K K K + +EG +L+ +R
Sbjct: 203 RLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKAPVEELDREGQRLLQCIRCSDGF 262
Query: 333 GSEPSVNQDQLDNQATVQR---LLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFRE 389
+ D Q+ V + LL +L+ T + W + KL+QC QLR FEQ +
Sbjct: 263 SGRNCI-PGSADFQSLVPKITSLLDKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQ---D 318
Query: 390 VKAILDAASQK----IATFTDIGNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQL 445
+ + D S + + T+IG S + L F S A + +L
Sbjct: 319 AEKMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMNSMNAYVNINRIMSVASRL 378
Query: 446 IGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSM-------KWC 498
HYA I+ +L F+A + R +L+ S H++ E + K C
Sbjct: 379 SEAGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMSAVFHQKAEQFLSGVDAWCKMC 438
Query: 499 DEG------------------IYLLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQE 540
EG +Y +Q + SQDG +A L +++ L G +
Sbjct: 439 SEGGLPSEMQDLELAIHHHQTLYEQVTQAYTEV-SQDG-KALLDVLQRPLSPGNSESL-- 494
Query: 541 LNAIYKEYESILNQDLMEHVRKVFQKQASMEEVFHRRQASL 581
Y ++Q +++ V +V Q +E ++ R+ L
Sbjct: 495 --TATANYSKAVHQ-VLDVVHEVLHHQRRLESIWQHRKVRL 532
Score = 58.9 bits (141), Expect = 3e-08
Identities = 73/319 (22%), Positives = 128/319 (40%), Gaps = 33/319 (10%)
Query: 290 DVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATV 349
D+ L HTE+K +++G + + + E+QA G E +D +D A V
Sbjct: 803 DLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYITEVQASGIELICEKD-IDLAAQV 861
Query: 350 QRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILDAASQKIATFTDIGN 409
Q LL L+E + + + ++LEQCLQLRH + ++V + + +
Sbjct: 862 QELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVKQVLGWIRNGESMLNASLVNAS 921
Query: 410 SLAHVEHLLRDLASFEEK-----SGVAVERARALSLDGEQ----LIGNKHYAVDSIRPKC 460
SL+ E L R+ F+ ++++ +L +Q L+ HY D+IR
Sbjct: 922 SLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQQKAEVLLQAGHYDADAIRECA 981
Query: 461 QELRHLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCD--EGIYLLASQPVDKCQSQD- 517
+++ Q ++ R L++ S+ ++ TS + C E + + D C +D
Sbjct: 982 EKVALHWQQLMLKMEDRLKLVNASVAFYK---TSEQVCSVLESLEQEYRRDEDWCGGRDK 1038
Query: 518 -GAEAALQEIEKFLETGAENKIQELNAIYKEYESILNQDLMEHVRKVFQKQASMEEVFHR 576
G A + + + E K L A L +VF K HR
Sbjct: 1039 LGPAAEIDHVIPLISKHLEQKEAFLKAC----------TLARRNAEVFLK------YIHR 1082
Query: 577 RQASLKKLAARQTRPVQPV 595
S+ +A+ P Q V
Sbjct: 1083 NNVSMPSVASHTRGPEQQV 1101
Score = 56.6 bits (135), Expect = 1e-07
Identities = 76/366 (20%), Positives = 141/366 (38%), Gaps = 46/366 (12%)
Query: 255 LCQRTAIESFALMVKQTAQMLQSFGTEL-----AETELPNDVQSTSSVLCAHTEKKDKAK 309
L +R+ I + + + Q A+ S G + +E LP+++Q + H ++
Sbjct: 407 LDERSTILAMSAVFHQKAEQFLS-GVDAWCKMCSEGGLPSEMQDLELAIHHHQTLYEQVT 465
Query: 310 EDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATVQRL--LAQLNETEAAFDEFW 367
+ ++G ++L+ L+ + G+ S+ ++A Q L + ++ + + W
Sbjct: 466 QAYTEVSQDGKALLDVLQRPLSPGNSESLTATANYSKAVHQVLDVVHEVLHHQRRLESIW 525
Query: 368 AKHQQKLEQCLQLRHFEQGFREVKAILDAASQK-IATFTDIGNSLAHVEHLLRDLASFEE 426
+ +L Q LQL F+Q ++V ++ + ++ T +G SL L + FEE
Sbjct: 526 QHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHDDFEE 585
Query: 427 KSGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLE 486
+ A L EQL + I + L F + +R+ LL S+
Sbjct: 586 VAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVS 645
Query: 487 LHRRLETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQELNAIYK 546
H + W ++ L D C D +A + I++F + LN I K
Sbjct: 646 FHTHTKELWTWMED---LQKEMLEDVCA--DSVDAVQELIKQFQQQQTATLDATLNVI-K 699
Query: 547 EYESILNQ---------------------------DLMEHVRKVFQK----QASMEEVFH 575
E E ++ Q + H+ V Q+ Q MEE+FH
Sbjct: 700 EGEDLIQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEELFH 759
Query: 576 RRQASL 581
R+ L
Sbjct: 760 ERKIKL 765
Score = 48.5 bits (114), Expect = 4e-05
Identities = 66/325 (20%), Positives = 136/325 (41%), Gaps = 36/325 (11%)
Query: 263 SFALMVKQTAQMLQSFGTELAETELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSV 322
SF K+ ++ E+ E + V + ++ +++ + +KEG +
Sbjct: 645 SFHTHTKELWTWMEDLQKEMLEDVCADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDL 704
Query: 323 LESLRELQAEGSEPSVNQDQ-LDNQAT--------VQRLLAQLNETEAAFDEFWAKHQQK 373
++ LR EPS +D + N T ++ +L QL++ + +E + + + K
Sbjct: 705 IQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEELFHERKIK 764
Query: 374 LEQCLQLRHFEQGFREVKAILDAASQKIATFTDIGNSLAHVEHLLRDLASFEEKSGVAVE 433
L+ LQLR FEQ EV A LDA ++ + + N+ DL E++ E
Sbjct: 765 LDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMNDFNT--------EDLTLAEQRLQRHTE 816
Query: 434 RARALSLDGEQLI---GNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRR 490
R A++ ++I + H + ++ EL +C++ A+ + LL E
Sbjct: 817 RKLAMNNMTFEVIQQGQDLHQYITEVQASGIEL--ICEKDIDLAAQVQELLEFLHEKQHE 874
Query: 491 LETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQELNAIYKEYES 550
LE + + + +++C +A ++++ ++ G LNA S
Sbjct: 875 LELNAE--------QTHKRLEQCLQLRHLQAEVKQVLGWIRNGE----SMLNASLVNASS 922
Query: 551 ILNQDLMEHVRKVFQKQASMEEVFH 575
+ + ++ + F Q ++E +FH
Sbjct: 923 LSEAEQLQREHEQF--QLAIESLFH 945
Score = 48.1 bits (113), Expect = 5e-05
Identities = 40/197 (20%), Positives = 80/197 (40%), Gaps = 3/197 (1%)
Query: 290 DVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATV 349
++ ++ H E+K+ + LA + L+ + S PSV + V
Sbjct: 1044 EIDHVIPLISKHLEQKEAFLKACTLARRNAEVFLKYIHRNNV--SMPSVASHTRGPEQQV 1101
Query: 350 QRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFRE-VKAILDAASQKIATFTDIG 408
+ +L++L + E FW +++L+QC Q FE+ ++ + I + ++T T G
Sbjct: 1102 KAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAKQALDWIQETGEFYLSTHTSTG 1161
Query: 409 NSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRHLCD 468
+ + LL++ F + E+ + L + + H IR +
Sbjct: 1162 ETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVEKGHIHATEIRKWVTTVDKHYR 1221
Query: 469 QFSAEIARRRGLLSKSL 485
FS + + R L K+L
Sbjct: 1222 DFSLRMGKYRYSLEKAL 1238
>gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens]
Length = 1663
Score = 226 bits (575), Expect = 1e-58
Identities = 167/522 (31%), Positives = 263/522 (50%), Gaps = 47/522 (9%)
Query: 503 YLLASQPVDKCQS----QDGAEAALQEIEKFLE------TGAENKIQELNAIYKEYES-- 550
+ L + +D+CQ + A+ AL I++ E T +E + KEY
Sbjct: 1119 WTLKKRRLDQCQQYVVFERSAKQALDWIQETGEFYLSTHTSTGETTEETQELLKEYGEFR 1178
Query: 551 ILNQDLMEHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPVAPRPEALAKSPCPSP 610
+ + E V+ + Q S E H ++K + + + R S +
Sbjct: 1179 VPAKQTKEKVKLLIQLADSFVEKGHIHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKAL 1238
Query: 611 GIRRGSENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRRHVMSELLDTE 670
G+ +N E + P + E+ + R EE+ A + +M+ELL TE
Sbjct: 1239 GVNT-EDNKDLELDII---PASLSDREV-KLRDANHEVNEEKRKSARKKEFIMAELLQTE 1293
Query: 671 RAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENY 730
+AYV +L LE Y EM + + + G+ NK+ ++FGN++EIY FHN IFL+ELE Y
Sbjct: 1294 KAYVRDLHECLETYLWEMTSGVEE--IPPGILNKEHIIFGNIQEIYDFHNNIFLKELEKY 1351
Query: 731 TDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRKLDHKLSLDSY 790
PE VG CF+ + FQ+Y YC+NKP S L + + FF E Q++ S+ SY
Sbjct: 1352 EQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAG-TFFDEIQQRHGLANSISSY 1410
Query: 791 LLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEALSSILGILKAVNDSMHLIAITGYDGN 850
L+KPVQRITKYQLLLKE+L EG +L++ L +L + K ND+MH+ + G+D N
Sbjct: 1411 LIKPVQRITKYQLLLKELLTCCE--EGKGELKDGLEVMLSVPKKANDAMHVSMLEGFDEN 1468
Query: 851 LGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYE 910
L G+L++Q +F VW K L R K +RHLFL E +++F K+ +++ G+
Sbjct: 1469 LDVQGELILQDAFQVWDP--------KSLIR-KGRERHLFLFEISLVFSKEIKDS-SGHT 1518
Query: 911 KAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYN---AREEVYIVQAPTPEIKAAWVNEI 967
K Y YK L + +G+TE+V+GD KF +W + + +++A E K W+ I
Sbjct: 1519 K---YVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETKQEWIKNI 1575
Query: 968 RKVLTSQLQACREASQHRALEQSQSLPLPAPTSTSPSRGNSR 1009
R+V+ ++ + A + PL P + + R NS+
Sbjct: 1576 REVIQERIIHLKGALKE---------PLQLPKTPAKQRNNSK 1608
Score = 163 bits (412), Expect = 1e-39
Identities = 136/521 (26%), Positives = 230/521 (44%), Gaps = 51/521 (9%)
Query: 94 LCAADIQDQLKKRFAYLSGGRGQDGSPVITFPDYPAFSEIPDKEFQNVMTYLTSIPSLQD 153
L A+D+ LK++ A++SGGR + G P++TFP I ++ + ++TYL S+PS
Sbjct: 30 LKASDVLPILKEKVAFVSGGRDKRGGPILTFPARSNHDRIRQEDLRKLVTYLASVPSEDV 89
Query: 154 AGIGFILVIDRRRDKWTSVKASVLRIAASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRD 213
GF ++ID R KW +K + + +FPA + + L+++P F+Q+ ++ F
Sbjct: 90 CKRGFTVIIDMRGSKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKTN----FGSS 145
Query: 214 DFKMKVPVIMLSSVPDLHGYIDKSQLTEDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQ 273
F + ++ SV L +D SQLTE+ G+LDY H W+ R ++E F
Sbjct: 146 KFIFETSMV---SVEGLTKLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLS 202
Query: 274 MLQSFGTELAETELPNDVQSTSSVLCAHTEKKDKA-KEDLRLALKEGHSVLESLRELQAE 332
L+ LA E P DV+ + ++ HT+ K K K + +EG +L+ +R
Sbjct: 203 RLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKAPVEELDREGQRLLQCIRCSDGF 262
Query: 333 GSEPSVNQDQLDNQATVQR---LLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFRE 389
+ D Q+ V + LL +L+ T + W + KL+QC QLR FEQ +
Sbjct: 263 SGRNCI-PGSADFQSLVPKITSLLDKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQ---D 318
Query: 390 VKAILDAASQK----IATFTDIGNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQL 445
+ + D S + + T+IG S + L F S A + +L
Sbjct: 319 AEKMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMNSMNAYVNINRIMSVASRL 378
Query: 446 IGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSM-------KWC 498
HYA I+ +L F+A + R +L+ S H++ E + K C
Sbjct: 379 SEAGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMSAVFHQKAEQFLSGVDAWCKMC 438
Query: 499 DEG------------------IYLLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQE 540
EG +Y +Q + SQDG +A L +++ L G +
Sbjct: 439 SEGGLPSEMQDLELAIHHHQTLYEQVTQAYTEV-SQDG-KALLDVLQRPLSPGNSESL-- 494
Query: 541 LNAIYKEYESILNQDLMEHVRKVFQKQASMEEVFHRRQASL 581
Y ++Q +++ V +V Q +E ++ R+ L
Sbjct: 495 --TATANYSKAVHQ-VLDVVHEVLHHQRRLESIWQHRKVRL 532
Score = 58.9 bits (141), Expect = 3e-08
Identities = 73/319 (22%), Positives = 128/319 (40%), Gaps = 33/319 (10%)
Query: 290 DVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATV 349
D+ L HTE+K +++G + + + E+QA G E +D +D A V
Sbjct: 803 DLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYITEVQASGIELICEKD-IDLAAQV 861
Query: 350 QRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILDAASQKIATFTDIGN 409
Q LL L+E + + + ++LEQCLQLRH + ++V + + +
Sbjct: 862 QELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVKQVLGWIRNGESMLNASLVNAS 921
Query: 410 SLAHVEHLLRDLASFEEK-----SGVAVERARALSLDGEQ----LIGNKHYAVDSIRPKC 460
SL+ E L R+ F+ ++++ +L +Q L+ HY D+IR
Sbjct: 922 SLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQQKAEVLLQAGHYDADAIRECA 981
Query: 461 QELRHLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCD--EGIYLLASQPVDKCQSQD- 517
+++ Q ++ R L++ S+ ++ TS + C E + + D C +D
Sbjct: 982 EKVALHWQQLMLKMEDRLKLVNASVAFYK---TSEQVCSVLESLEQEYRRDEDWCGGRDK 1038
Query: 518 -GAEAALQEIEKFLETGAENKIQELNAIYKEYESILNQDLMEHVRKVFQKQASMEEVFHR 576
G A + + + E K L A L +VF K HR
Sbjct: 1039 LGPAAEIDHVIPLISKHLEQKEAFLKAC----------TLARRNAEVFLK------YIHR 1082
Query: 577 RQASLKKLAARQTRPVQPV 595
S+ +A+ P Q V
Sbjct: 1083 NNVSMPSVASHTRGPEQQV 1101
Score = 56.6 bits (135), Expect = 1e-07
Identities = 76/366 (20%), Positives = 141/366 (38%), Gaps = 46/366 (12%)
Query: 255 LCQRTAIESFALMVKQTAQMLQSFGTEL-----AETELPNDVQSTSSVLCAHTEKKDKAK 309
L +R+ I + + + Q A+ S G + +E LP+++Q + H ++
Sbjct: 407 LDERSTILAMSAVFHQKAEQFLS-GVDAWCKMCSEGGLPSEMQDLELAIHHHQTLYEQVT 465
Query: 310 EDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATVQRL--LAQLNETEAAFDEFW 367
+ ++G ++L+ L+ + G+ S+ ++A Q L + ++ + + W
Sbjct: 466 QAYTEVSQDGKALLDVLQRPLSPGNSESLTATANYSKAVHQVLDVVHEVLHHQRRLESIW 525
Query: 368 AKHQQKLEQCLQLRHFEQGFREVKAILDAASQK-IATFTDIGNSLAHVEHLLRDLASFEE 426
+ +L Q LQL F+Q ++V ++ + ++ T +G SL L + FEE
Sbjct: 526 QHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHDDFEE 585
Query: 427 KSGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLE 486
+ A L EQL + I + L F + +R+ LL S+
Sbjct: 586 VAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVS 645
Query: 487 LHRRLETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQELNAIYK 546
H + W ++ L D C D +A + I++F + LN I K
Sbjct: 646 FHTHTKELWTWMED---LQKEMLEDVCA--DSVDAVQELIKQFQQQQTATLDATLNVI-K 699
Query: 547 EYESILNQ---------------------------DLMEHVRKVFQK----QASMEEVFH 575
E E ++ Q + H+ V Q+ Q MEE+FH
Sbjct: 700 EGEDLIQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEELFH 759
Query: 576 RRQASL 581
R+ L
Sbjct: 760 ERKIKL 765
Score = 48.5 bits (114), Expect = 4e-05
Identities = 66/325 (20%), Positives = 136/325 (41%), Gaps = 36/325 (11%)
Query: 263 SFALMVKQTAQMLQSFGTELAETELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSV 322
SF K+ ++ E+ E + V + ++ +++ + +KEG +
Sbjct: 645 SFHTHTKELWTWMEDLQKEMLEDVCADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDL 704
Query: 323 LESLRELQAEGSEPSVNQDQ-LDNQAT--------VQRLLAQLNETEAAFDEFWAKHQQK 373
++ LR EPS +D + N T ++ +L QL++ + +E + + + K
Sbjct: 705 IQQLRSAPPSLGEPSEARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEELFHERKIK 764
Query: 374 LEQCLQLRHFEQGFREVKAILDAASQKIATFTDIGNSLAHVEHLLRDLASFEEKSGVAVE 433
L+ LQLR FEQ EV A LDA ++ + + N+ DL E++ E
Sbjct: 765 LDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMNDFNT--------EDLTLAEQRLQRHTE 816
Query: 434 RARALSLDGEQLI---GNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRR 490
R A++ ++I + H + ++ EL +C++ A+ + LL E
Sbjct: 817 RKLAMNNMTFEVIQQGQDLHQYITEVQASGIEL--ICEKDIDLAAQVQELLEFLHEKQHE 874
Query: 491 LETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQELNAIYKEYES 550
LE + + + +++C +A ++++ ++ G LNA S
Sbjct: 875 LELNAE--------QTHKRLEQCLQLRHLQAEVKQVLGWIRNGE----SMLNASLVNASS 922
Query: 551 ILNQDLMEHVRKVFQKQASMEEVFH 575
+ + ++ + F Q ++E +FH
Sbjct: 923 LSEAEQLQREHEQF--QLAIESLFH 945
Score = 48.1 bits (113), Expect = 5e-05
Identities = 40/197 (20%), Positives = 80/197 (40%), Gaps = 3/197 (1%)
Query: 290 DVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATV 349
++ ++ H E+K+ + LA + L+ + S PSV + V
Sbjct: 1044 EIDHVIPLISKHLEQKEAFLKACTLARRNAEVFLKYIHRNNV--SMPSVASHTRGPEQQV 1101
Query: 350 QRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFRE-VKAILDAASQKIATFTDIG 408
+ +L++L + E FW +++L+QC Q FE+ ++ + I + ++T T G
Sbjct: 1102 KAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAKQALDWIQETGEFYLSTHTSTG 1161
Query: 409 NSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRHLCD 468
+ + LL++ F + E+ + L + + H IR +
Sbjct: 1162 ETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVEKGHIHATEIRKWVTTVDKHYR 1221
Query: 469 QFSAEIARRRGLLSKSL 485
FS + + R L K+L
Sbjct: 1222 DFSLRMGKYRYSLEKAL 1238
>gi|148529025 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4B [Homo sapiens]
Length = 1271
Score = 195 bits (496), Expect = 2e-49
Identities = 125/329 (37%), Positives = 183/329 (55%), Gaps = 31/329 (9%)
Query: 660 RHVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFH 719
RH+M+E++ TER Y+ L V++ Y EM+ L GL K V+FGN+E+++ FH
Sbjct: 807 RHIMAEMIATEREYIRCLGYVIDNYFPEMERMD----LPQGLRGKHHVIFGNLEKLHDFH 862
Query: 720 NRIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQR 779
+ FLRELE CP VGR FL E F +Y Y +NKP+S++L + FF++ QR
Sbjct: 863 QQHFLRELERCQHCPLAVGRSFLRHEEQFGMYVIYSKNKPQSDALLSSHGNA-FFKDKQR 921
Query: 780 KLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNC---EGAE--DLQEALSSILGILKA 834
+L K+ L SYLL+PVQR+ KY LLL+++LK +C +G E +L+ A + L+
Sbjct: 922 ELGDKMDLASYLLRPVQRVAKYALLLQDLLK-EASCGLAQGQELGELRAAEVVVCFQLRH 980
Query: 835 VNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEK 894
ND + + AI G D NL + G+L + F V K+ RH+FL E
Sbjct: 981 GNDLLAMDAIRGCDVNLKEQGQLRCRDEFIVCCGRKK-------------YLRHVFLFED 1027
Query: 895 AVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNAR---EEVYI 951
+LF K ++ G Y YKQS A +G+TENV +FEIW+ R ++ YI
Sbjct: 1028 LILFSKTQKVEG----SHDVYLYKQSFKTAEIGMTENVGDSGLRFEIWFRRRRKSQDTYI 1083
Query: 952 VQAPTPEIKAAWVNEIRKVLTSQLQACRE 980
+QA + E+K+AW + I ++L Q RE
Sbjct: 1084 LQASSAEVKSAWTDVIGRILWRQALKSRE 1112
Score = 66.6 bits (161), Expect = 1e-10
Identities = 68/261 (26%), Positives = 110/261 (42%), Gaps = 30/261 (11%)
Query: 137 EFQNVMTYLTSIPSLQDAGIGFILVIDRRRDKWT---SVKASVLRIAASFPANLQLVLVL 193
E ++ Y SIP + +G ++++D RR S S L+ S + L+LV
Sbjct: 235 ELTRLLLYFHSIPRKEVRDLGLVVLVDARRSPAAPAVSQALSGLQNNTSPIIHSILLLVD 294
Query: 194 RPTGFFQRTLSDIAFKFNRDDFKMKVPVIMLSSVPDLHGYIDKSQLTEDLGGTLDYCHSR 253
+ + F R D + ++SS+ +H ++D QLT DL G+ Y H
Sbjct: 295 KESAF-------------RPDKDAIIQCEVVSSLKAVHKFVDSCQLTADLDGSFPYSHGD 341
Query: 254 WLCQRTAIESFALMVKQTAQMLQSFGTELAETELPNDVQSTSSVLCAH-TEKKDKAKEDL 312
W+C R +E FA ++ LQ+ L P Q + ++ H T K ++ L
Sbjct: 342 WICFRQRLEHFAANCEEAIIFLQNSFCSLNTHRTPRTAQEVAELIDQHETMMKLVLEDPL 401
Query: 313 RLALK-EGHSVLESLR--ELQAEGSEPSVN-----QDQLDNQA-----TVQRLLAQLNET 359
++L+ EG +VL LR EL E S ++ D++D + T L QL
Sbjct: 402 LVSLRLEGGTVLARLRREELGTEDSRDTLEAATSLYDRVDEEVHRLVLTSNNRLQQLEHL 461
Query: 360 EAAFDEFWAKHQQKLEQCLQL 380
QQ ++ LQL
Sbjct: 462 RELASLLEGNDQQSCQKGLQL 482
>gi|150417975 RhoA/RAC/CDC42 exchange factor isoform 1 [Homo sapiens]
Length = 580
Score = 192 bits (488), Expect = 2e-48
Identities = 128/390 (32%), Positives = 211/390 (54%), Gaps = 22/390 (5%)
Query: 626 LRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRR-HVMSELLDTERAYVEELLCVLEGY 684
L GP + + E+ + EE++ A+ R +V+SEL++TE+ YV++L ++EGY
Sbjct: 127 LLEGPGDKTQPPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGY 186
Query: 685 AAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLER 744
A M A + L + ++FGN+++IY +H FL+EL+ P+ + + F++
Sbjct: 187 MATM----AAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKH 242
Query: 745 MEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLL 804
+Y YCQNKP+SE + + D +F+E +++L H+L L+ L+KPVQRI KYQLL
Sbjct: 243 ERRLHMYVVYCQNKPKSEHVVSEFGD-SYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLL 301
Query: 805 LKEMLK-YSRNCEGAEDLQEALSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSF 863
LK+ LK Y+R DL++A+ + + K ND M L + G++G L GKLL Q +F
Sbjct: 302 LKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTF 361
Query: 864 SVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNM 923
V G L + +R +FL E+ ++F + G + P Y YK S+ +
Sbjct: 362 WVTEPEAGG------LLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQ-PGYVYKNSIKV 414
Query: 924 AAVGITENVKGDAKKFEIWYNARE---EVYIVQAPTPEIKAAWVNEIRKVLTSQ---LQA 977
+ +G+ N++GD +F + E + Y++QA P I AW+ + ++L SQ L A
Sbjct: 415 SCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFLNA 474
Query: 978 CREASQHRALE-QSQSLPLP-APTSTSPSR 1005
+ +++ E Q+ SL P P SP R
Sbjct: 475 LQSPIEYQRRESQTNSLGRPRGPGVGSPGR 504
>gi|162287076 RhoA/RAC/CDC42 exchange factor isoform 3 [Homo sapiens]
Length = 619
Score = 192 bits (488), Expect = 2e-48
Identities = 128/390 (32%), Positives = 211/390 (54%), Gaps = 22/390 (5%)
Query: 626 LRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRR-HVMSELLDTERAYVEELLCVLEGY 684
L GP + + E+ + EE++ A+ R +V+SEL++TE+ YV++L ++EGY
Sbjct: 166 LLEGPGDKTQPPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGY 225
Query: 685 AAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLER 744
A M A + L + ++FGN+++IY +H FL+EL+ P+ + + F++
Sbjct: 226 MATM----AAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKH 281
Query: 745 MEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLL 804
+Y YCQNKP+SE + + D +F+E +++L H+L L+ L+KPVQRI KYQLL
Sbjct: 282 ERRLHMYVVYCQNKPKSEHVVSEFGD-SYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLL 340
Query: 805 LKEMLK-YSRNCEGAEDLQEALSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSF 863
LK+ LK Y+R DL++A+ + + K ND M L + G++G L GKLL Q +F
Sbjct: 341 LKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTF 400
Query: 864 SVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNM 923
V G L + +R +FL E+ ++F + G + P Y YK S+ +
Sbjct: 401 WVTEPEAGG------LLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQ-PGYVYKNSIKV 453
Query: 924 AAVGITENVKGDAKKFEIWYNARE---EVYIVQAPTPEIKAAWVNEIRKVLTSQ---LQA 977
+ +G+ N++GD +F + E + Y++QA P I AW+ + ++L SQ L A
Sbjct: 454 SCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFLNA 513
Query: 978 CREASQHRALE-QSQSLPLP-APTSTSPSR 1005
+ +++ E Q+ SL P P SP R
Sbjct: 514 LQSPIEYQRRESQTNSLGRPRGPGVGSPGR 543
>gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens]
Length = 1289
Score = 191 bits (486), Expect = 3e-48
Identities = 147/523 (28%), Positives = 250/523 (47%), Gaps = 60/523 (11%)
Query: 650 EEEESLAILRRH--VMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDV 707
EEE+ LR V++EL+ TE+ YV++L V+EG+ ++ + + K +
Sbjct: 222 EEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPE----DMRGKDKI 277
Query: 708 LFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQ 767
+FGN+ +IY +H FL ELE + + + F++ IY YCQNKPRSE + +
Sbjct: 278 VFGNIHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAE 337
Query: 768 CSDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAE--DLQEAL 825
+F+E +++++ +L+L +L+KP+QRITKYQLLLK+ L+YS G E D+++A+
Sbjct: 338 YD--AYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKA-GLECSDIEKAV 394
Query: 826 SSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPM 885
+ + K ND M+L + G++G L GKLL Q +F V ++ KE
Sbjct: 395 ELMCLVPKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGMQSRTKE------- 447
Query: 886 QRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNA 945
R +FL E+ V+F + + P Y +K+S+ M + + ENV D KF +
Sbjct: 448 -RRVFLFEQIVIFSELLRKG----SLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRE 502
Query: 946 REEVYIVQAPTPEIKAAWVNEIRKVLTSQ---LQACREASQHRALEQSQSLPLPAPTSTS 1002
E ++QA +I+ AWV +I +VL +Q L A + +++ E+S ++ P
Sbjct: 503 TSERVVLQAANADIQQAWVQDINQVLETQRDFLNALQSPIEYQRKERSTAVMRSQPA--- 559
Query: 1003 PSRGNSRNIKKLEERKTDPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPEDDGG---- 1058
+L + P Y S ++ P KG ++ L+ +G
Sbjct: 560 ----------RLPQASPRP-----YSSVPAGSEKPPKGSSYNPPLPPLKISTSNGSPGFE 604
Query: 1059 WSSAEEQINSSDAEEDGGLGPKKLVPGKYTVVADHEKGGPDALRVRSGDVVELVQEGDEG 1118
+ ++ +S + GG V+ D+ + + V G+VV+++ +
Sbjct: 605 YHQPGDKFEASKQNDLGGCNG----TSSMAVIKDYYALKENEICVSQGEVVQVLAVNQQN 660
Query: 1119 LWYVRDPTT----GKEGWVPASSLSVRLGPSGSAQCLSSSESS 1157
+ V P + EGWVP S L+ P A SS+ S
Sbjct: 661 MCLVYQPASDHSPAAEGWVPGSILA----PLTKATAAESSDGS 699
>gi|193211598 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 190 bits (482), Expect = 8e-48
Identities = 230/895 (25%), Positives = 376/895 (42%), Gaps = 78/895 (8%)
Query: 103 LKKRFAYLSGGRGQDGSPVITFPDY-PAF--SEIPDKEFQNVMTYLTSIPSLQDAGIGFI 159
L A L G R G V+ + PA+ SE +E ++ YL SIP + +G
Sbjct: 190 LASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALGLT 249
Query: 160 LVIDRRR-DKWTSVKASVLRIAASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRDDFKMK 218
+++D R +S+ + + ++ + P + VL++ T +
Sbjct: 250 VLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGST------------------LLKE 291
Query: 219 VPV-IMLSSVPD--LHGYIDKSQLTEDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQML 275
VP + L +P L +I + L LGG L YCH WL R +E+ + +L
Sbjct: 292 VPSGLQLEQLPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALL 351
Query: 276 QSFGTELAETELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSE 335
Q + P + +L + + LA + E L L+ E E
Sbjct: 352 QGAIESVKAVPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRE-LTWLKQEVPE 410
Query: 336 PSVNQDQLDNQATVQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILD 395
+++ D L +++ + Q LE L E G +++ L
Sbjct: 411 VTLSPDYRTAMDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQ 470
Query: 396 AASQKIATFTDIGNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQLIGNKHYAVDS 455
+ G ++ LL+ SF+E VA E+ R + L G + +D
Sbjct: 471 QVGWP--ALEEAGEP--SLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDP 526
Query: 456 IRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCDEGIYLLASQPVDKCQS 515
+ LR +FS +A+R L+ + L + ++ W +EG +LA
Sbjct: 527 PGARFLALRAQLTEFSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAEL------E 580
Query: 516 QDGAEAALQEIEKFLETGAENKIQELNAIYKEYESILNQDLMEHVRKVFQK-QASMEEVF 574
Q+ LQ+++ + ++ + ++ + + R + + Q + +
Sbjct: 581 QERPGVVLQQLQLHWTRHPDLPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALD 640
Query: 575 HRRQASLKKLAARQTRPV----QPVAPRPEALAKSPCPSPGIRRG-SENSSSEGGALRRG 629
+ +ASLK T + P AP L K+ + + SE + A
Sbjct: 641 QKLEASLKLPPVGSTASLCVSQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIA 700
Query: 630 PYRRAKSEMSESRQGRGSA----GEEEESLAILRRHVMSELLDTERAYVEELLCVLEGYA 685
RR ++ Q + + SL L+ V++E++ TER YV L +E Y
Sbjct: 701 ACRRPEAGGGALPQASPTVPPPGSSDPRSLNRLQL-VLAEMVATEREYVRALEYTMENYF 759
Query: 686 AEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLERM 745
E+D P + GL ++ LFGN+E++ FH FLRELE T P V FL
Sbjct: 760 PELDRPDVPQ----GLRGQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHR 815
Query: 746 EDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLLL 805
F +Y Y +NKPRS++L FF++ Q+ L L L SYLLKP+QR+ KY LLL
Sbjct: 816 VQFGMYALYSKNKPRSDALMSSYGH-TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLL 874
Query: 806 KEMLKYSRNCEGAED----LQEALSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQG 861
+E+ +R C G L+EA S + L+ ND + + AI G D NL + G+L+ Q
Sbjct: 875 QEL---ARACGGPTQELSALREAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQD 931
Query: 862 SFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSL 921
F V T H V R +FL E+ +LF K R G +++YK+S
Sbjct: 932 EFVVRTGR---HKSV----------RRIFLFEELLLFSKPR----HGPTGVDTFAYKRSF 974
Query: 922 NMAAVGITENVKGDAKKFEIWYNARE--EVYIVQAPTPEIKAAWVNEIRKVLTSQ 974
MA +G+TE +FEIW+ R+ + +++QA + IK AW +I +L Q
Sbjct: 975 KMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTADISHLLWRQ 1029
>gi|193211596 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 190 bits (482), Expect = 8e-48
Identities = 230/895 (25%), Positives = 376/895 (42%), Gaps = 78/895 (8%)
Query: 103 LKKRFAYLSGGRGQDGSPVITFPDY-PAF--SEIPDKEFQNVMTYLTSIPSLQDAGIGFI 159
L A L G R G V+ + PA+ SE +E ++ YL SIP + +G
Sbjct: 190 LASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALGLT 249
Query: 160 LVIDRRR-DKWTSVKASVLRIAASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRDDFKMK 218
+++D R +S+ + + ++ + P + VL++ T +
Sbjct: 250 VLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGST------------------LLKE 291
Query: 219 VPV-IMLSSVPD--LHGYIDKSQLTEDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQML 275
VP + L +P L +I + L LGG L YCH WL R +E+ + +L
Sbjct: 292 VPSGLQLEQLPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALL 351
Query: 276 QSFGTELAETELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSE 335
Q + P + +L + + LA + E L L+ E E
Sbjct: 352 QGAIESVKAVPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRE-LTWLKQEVPE 410
Query: 336 PSVNQDQLDNQATVQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILD 395
+++ D L +++ + Q LE L E G +++ L
Sbjct: 411 VTLSPDYRTAMDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQ 470
Query: 396 AASQKIATFTDIGNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQLIGNKHYAVDS 455
+ G ++ LL+ SF+E VA E+ R + L G + +D
Sbjct: 471 QVGWP--ALEEAGEP--SLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDP 526
Query: 456 IRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCDEGIYLLASQPVDKCQS 515
+ LR +FS +A+R L+ + L + ++ W +EG +LA
Sbjct: 527 PGARFLALRAQLTEFSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAEL------E 580
Query: 516 QDGAEAALQEIEKFLETGAENKIQELNAIYKEYESILNQDLMEHVRKVFQK-QASMEEVF 574
Q+ LQ+++ + ++ + ++ + + R + + Q + +
Sbjct: 581 QERPGVVLQQLQLHWTRHPDLPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALD 640
Query: 575 HRRQASLKKLAARQTRPV----QPVAPRPEALAKSPCPSPGIRRG-SENSSSEGGALRRG 629
+ +ASLK T + P AP L K+ + + SE + A
Sbjct: 641 QKLEASLKLPPVGSTASLCVSQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIA 700
Query: 630 PYRRAKSEMSESRQGRGSA----GEEEESLAILRRHVMSELLDTERAYVEELLCVLEGYA 685
RR ++ Q + + SL L+ V++E++ TER YV L +E Y
Sbjct: 701 ACRRPEAGGGALPQASPTVPPPGSSDPRSLNRLQL-VLAEMVATEREYVRALEYTMENYF 759
Query: 686 AEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLERM 745
E+D P + GL ++ LFGN+E++ FH FLRELE T P V FL
Sbjct: 760 PELDRPDVPQ----GLRGQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHR 815
Query: 746 EDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLLL 805
F +Y Y +NKPRS++L FF++ Q+ L L L SYLLKP+QR+ KY LLL
Sbjct: 816 VQFGMYALYSKNKPRSDALMSSYGH-TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLL 874
Query: 806 KEMLKYSRNCEGAED----LQEALSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQG 861
+E+ +R C G L+EA S + L+ ND + + AI G D NL + G+L+ Q
Sbjct: 875 QEL---ARACGGPTQELSALREAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQD 931
Query: 862 SFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSL 921
F V T H V R +FL E+ +LF K R G +++YK+S
Sbjct: 932 EFVVRTGR---HKSV----------RRIFLFEELLLFSKPR----HGPTGVDTFAYKRSF 974
Query: 922 NMAAVGITENVKGDAKKFEIWYNARE--EVYIVQAPTPEIKAAWVNEIRKVLTSQ 974
MA +G+TE +FEIW+ R+ + +++QA + IK AW +I +L Q
Sbjct: 975 KMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTADISHLLWRQ 1029
>gi|193211594 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 190 bits (482), Expect = 8e-48
Identities = 230/895 (25%), Positives = 376/895 (42%), Gaps = 78/895 (8%)
Query: 103 LKKRFAYLSGGRGQDGSPVITFPDY-PAF--SEIPDKEFQNVMTYLTSIPSLQDAGIGFI 159
L A L G R G V+ + PA+ SE +E ++ YL SIP + +G
Sbjct: 190 LASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALGLT 249
Query: 160 LVIDRRR-DKWTSVKASVLRIAASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRDDFKMK 218
+++D R +S+ + + ++ + P + VL++ T +
Sbjct: 250 VLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGST------------------LLKE 291
Query: 219 VPV-IMLSSVPD--LHGYIDKSQLTEDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQML 275
VP + L +P L +I + L LGG L YCH WL R +E+ + +L
Sbjct: 292 VPSGLQLEQLPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALL 351
Query: 276 QSFGTELAETELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSE 335
Q + P + +L + + LA + E L L+ E E
Sbjct: 352 QGAIESVKAVPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRE-LTWLKQEVPE 410
Query: 336 PSVNQDQLDNQATVQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILD 395
+++ D L +++ + Q LE L E G +++ L
Sbjct: 411 VTLSPDYRTAMDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQ 470
Query: 396 AASQKIATFTDIGNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQLIGNKHYAVDS 455
+ G ++ LL+ SF+E VA E+ R + L G + +D
Sbjct: 471 QVGWP--ALEEAGEP--SLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDP 526
Query: 456 IRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCDEGIYLLASQPVDKCQS 515
+ LR +FS +A+R L+ + L + ++ W +EG +LA
Sbjct: 527 PGARFLALRAQLTEFSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAEL------E 580
Query: 516 QDGAEAALQEIEKFLETGAENKIQELNAIYKEYESILNQDLMEHVRKVFQK-QASMEEVF 574
Q+ LQ+++ + ++ + ++ + + R + + Q + +
Sbjct: 581 QERPGVVLQQLQLHWTRHPDLPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALD 640
Query: 575 HRRQASLKKLAARQTRPV----QPVAPRPEALAKSPCPSPGIRRG-SENSSSEGGALRRG 629
+ +ASLK T + P AP L K+ + + SE + A
Sbjct: 641 QKLEASLKLPPVGSTASLCVSQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIA 700
Query: 630 PYRRAKSEMSESRQGRGSA----GEEEESLAILRRHVMSELLDTERAYVEELLCVLEGYA 685
RR ++ Q + + SL L+ V++E++ TER YV L +E Y
Sbjct: 701 ACRRPEAGGGALPQASPTVPPPGSSDPRSLNRLQL-VLAEMVATEREYVRALEYTMENYF 759
Query: 686 AEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLERM 745
E+D P + GL ++ LFGN+E++ FH FLRELE T P V FL
Sbjct: 760 PELDRPDVPQ----GLRGQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHR 815
Query: 746 EDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLLL 805
F +Y Y +NKPRS++L FF++ Q+ L L L SYLLKP+QR+ KY LLL
Sbjct: 816 VQFGMYALYSKNKPRSDALMSSYGH-TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLL 874
Query: 806 KEMLKYSRNCEGAED----LQEALSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQG 861
+E+ +R C G L+EA S + L+ ND + + AI G D NL + G+L+ Q
Sbjct: 875 QEL---ARACGGPTQELSALREAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQD 931
Query: 862 SFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSL 921
F V T H V R +FL E+ +LF K R G +++YK+S
Sbjct: 932 EFVVRTGR---HKSV----------RRIFLFEELLLFSKPR----HGPTGVDTFAYKRSF 974
Query: 922 NMAAVGITENVKGDAKKFEIWYNARE--EVYIVQAPTPEIKAAWVNEIRKVLTSQ 974
MA +G+TE +FEIW+ R+ + +++QA + IK AW +I +L Q
Sbjct: 975 KMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTADISHLLWRQ 1029
>gi|55742734 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 190 bits (482), Expect = 8e-48
Identities = 230/895 (25%), Positives = 376/895 (42%), Gaps = 78/895 (8%)
Query: 103 LKKRFAYLSGGRGQDGSPVITFPDY-PAF--SEIPDKEFQNVMTYLTSIPSLQDAGIGFI 159
L A L G R G V+ + PA+ SE +E ++ YL SIP + +G
Sbjct: 190 LASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALGLT 249
Query: 160 LVIDRRR-DKWTSVKASVLRIAASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRDDFKMK 218
+++D R +S+ + + ++ + P + VL++ T +
Sbjct: 250 VLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGST------------------LLKE 291
Query: 219 VPV-IMLSSVPD--LHGYIDKSQLTEDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQML 275
VP + L +P L +I + L LGG L YCH WL R +E+ + +L
Sbjct: 292 VPSGLQLEQLPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALL 351
Query: 276 QSFGTELAETELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSE 335
Q + P + +L + + LA + E L L+ E E
Sbjct: 352 QGAIESVKAVPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRE-LTWLKQEVPE 410
Query: 336 PSVNQDQLDNQATVQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILD 395
+++ D L +++ + Q LE L E G +++ L
Sbjct: 411 VTLSPDYRTAMDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQ 470
Query: 396 AASQKIATFTDIGNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQLIGNKHYAVDS 455
+ G ++ LL+ SF+E VA E+ R + L G + +D
Sbjct: 471 QVGWP--ALEEAGEP--SLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDP 526
Query: 456 IRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCDEGIYLLASQPVDKCQS 515
+ LR +FS +A+R L+ + L + ++ W +EG +LA
Sbjct: 527 PGARFLALRAQLTEFSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAEL------E 580
Query: 516 QDGAEAALQEIEKFLETGAENKIQELNAIYKEYESILNQDLMEHVRKVFQK-QASMEEVF 574
Q+ LQ+++ + ++ + ++ + + R + + Q + +
Sbjct: 581 QERPGVVLQQLQLHWTRHPDLPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALD 640
Query: 575 HRRQASLKKLAARQTRPV----QPVAPRPEALAKSPCPSPGIRRG-SENSSSEGGALRRG 629
+ +ASLK T + P AP L K+ + + SE + A
Sbjct: 641 QKLEASLKLPPVGSTASLCVSQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIA 700
Query: 630 PYRRAKSEMSESRQGRGSA----GEEEESLAILRRHVMSELLDTERAYVEELLCVLEGYA 685
RR ++ Q + + SL L+ V++E++ TER YV L +E Y
Sbjct: 701 ACRRPEAGGGALPQASPTVPPPGSSDPRSLNRLQL-VLAEMVATEREYVRALEYTMENYF 759
Query: 686 AEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLERM 745
E+D P + GL ++ LFGN+E++ FH FLRELE T P V FL
Sbjct: 760 PELDRPDVPQ----GLRGQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHR 815
Query: 746 EDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLLL 805
F +Y Y +NKPRS++L FF++ Q+ L L L SYLLKP+QR+ KY LLL
Sbjct: 816 VQFGMYALYSKNKPRSDALMSSYGH-TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLL 874
Query: 806 KEMLKYSRNCEGAED----LQEALSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQG 861
+E+ +R C G L+EA S + L+ ND + + AI G D NL + G+L+ Q
Sbjct: 875 QEL---ARACGGPTQELSALREAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQD 931
Query: 862 SFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSL 921
F V T H V R +FL E+ +LF K R G +++YK+S
Sbjct: 932 EFVVRTGR---HKSV----------RRIFLFEELLLFSKPR----HGPTGVDTFAYKRSF 974
Query: 922 NMAAVGITENVKGDAKKFEIWYNARE--EVYIVQAPTPEIKAAWVNEIRKVLTSQ 974
MA +G+TE +FEIW+ R+ + +++QA + IK AW +I +L Q
Sbjct: 975 KMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTADISHLLWRQ 1029
>gi|193211603 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 2 [Homo sapiens]
Length = 1110
Score = 188 bits (477), Expect = 3e-47
Identities = 221/864 (25%), Positives = 364/864 (42%), Gaps = 75/864 (8%)
Query: 131 SEIPDKEFQNVMTYLTSIPSLQDAGIGFILVIDRRR-DKWTSVKASVLRIAASFPANLQL 189
SE +E ++ YL SIP + +G +++D R +S+ + + ++ + P +
Sbjct: 140 SECSSQELIRLLLYLRSIPRPEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQ 199
Query: 190 VLVLRPTGFFQRTLSDIAFKFNRDDFKMKVPV-IMLSSVPD--LHGYIDKSQLTEDLGGT 246
VL++ T +VP + L +P L +I + L LGG
Sbjct: 200 VLLVGST------------------LLKEVPSGLQLEQLPSQSLLTHIPTAGLPTSLGGG 241
Query: 247 LDYCHSRWLCQRTAIESFALMVKQTAQMLQSFGTELAETELPNDVQSTSSVLCAHTEKKD 306
L YCH WL R +E+ + +LQ + P + +L
Sbjct: 242 LPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKAVPQPMEPGEVGQLLQQTEVLMQ 301
Query: 307 KAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATVQRLLAQLNETEAAFDEF 366
+ + LA + E L L+ E E +++ D L +++
Sbjct: 302 QVLDSPWLAWLQCQGGRE-LTWLKQEVPEVTLSPDYRTAMDKADELYDRVDGLLHQLTLQ 360
Query: 367 WAKHQQKLEQCLQLRHFEQGFREVKAILDAASQKIATFTDIGNSLAHVEHLLRDLASFEE 426
+ Q LE L E G +++ L + G ++ LL+ SF+E
Sbjct: 361 SNQRIQALELVQTLEARESGLHQIEVWLQQVGWP--ALEEAGEP--SLDMLLQAQGSFQE 416
Query: 427 KSGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLE 486
VA E+ R + L G + +D + LR +FS +A+R L+ +
Sbjct: 417 LYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTEFSRALAQRCQRLADAER 476
Query: 487 LHRRLETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQELNAIYK 546
L + ++ W +EG +LA Q+ LQ+++ + ++
Sbjct: 477 LFQLFREALTWAEEGQRVLAEL------EQERPGVVLQQLQLHWTRHPDLPPAHFRKMWA 530
Query: 547 EYESILNQDLMEHVRKVFQK-QASMEEVFHRRQASLKKLAARQTRPV----QPVAPRPEA 601
+ ++ + + R + + Q + + + +ASLK T + P AP
Sbjct: 531 LATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCVSQVPAAPAHPP 590
Query: 602 LAKSPCPSPGIRRG-SENSSSEGGALRRGPYRRAKSEMSESRQGRGSA----GEEEESLA 656
L K+ + + SE + A RR ++ Q + + SL
Sbjct: 591 LRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVPPPGSSDPRSLN 650
Query: 657 ILRRHVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIY 716
L+ V++E++ TER YV L +E Y E+D P + GL ++ LFGN+E++
Sbjct: 651 RLQL-VLAEMVATEREYVRALEYTMENYFPELDRPDVPQ----GLRGQRAHLFGNLEKLR 705
Query: 717 HFHNRIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPFFQE 776
FH FLRELE T P V FL F +Y Y +NKPRS++L FF++
Sbjct: 706 DFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH-TFFKD 764
Query: 777 CQRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAED----LQEALSSILGIL 832
Q+ L L L SYLLKP+QR+ KY LLL+E+ +R C G L+EA S + L
Sbjct: 765 KQQALGDHLDLASYLLKPIQRMGKYALLLQEL---ARACGGPTQELSALREAQSLVHFQL 821
Query: 833 KAVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLH 892
+ ND + + AI G D NL + G+L+ Q F V T H V R +FL
Sbjct: 822 RHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGR---HKSV----------RRIFLF 868
Query: 893 EKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNARE--EVY 950
E+ +LF K R G +++YK+S MA +G+TE +FEIW+ R+ + +
Sbjct: 869 EELLLFSKPR----HGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTF 924
Query: 951 IVQAPTPEIKAAWVNEIRKVLTSQ 974
++QA + IK AW +I +L Q
Sbjct: 925 VLQASSLAIKQAWTADISHLLWRQ 948
>gi|71274148 pleckstrin homology domain containing, family G (with
RhoGef domain) member 1 [Homo sapiens]
Length = 1385
Score = 141 bits (356), Expect = 3e-33
Identities = 113/418 (27%), Positives = 203/418 (48%), Gaps = 60/418 (14%)
Query: 662 VMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNR 721
V+ E+L+TER YV++L ++E Y + + L + ++ LFGN+++IYHF++
Sbjct: 117 VVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGT----EERSALFGNIQDIYHFNSE 172
Query: 722 IFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSD----CPFFQEC 777
+ L++LEN + P + CF+ + E+F IY +YC N PRS ++ +C FF+E
Sbjct: 173 L-LQDLENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRER 231
Query: 778 QRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKY-SRNCEGAEDLQEALSSILGILKAVN 836
Q L H L L SYLLKPVQRI KY LLL E+ + ++ EG + + +A+ ++ + +N
Sbjct: 232 QETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHIN 291
Query: 837 DSM----HLI-------AITGYDG-NLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKP 884
D H + +T + G +L G+L+++G+F + + K
Sbjct: 292 DMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRI--------QRAKN------ 337
Query: 885 MQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYN 944
+R LFL +K +L KKR++ +++YK + + + E + + F +++
Sbjct: 338 -ERTLFLFDKLLLITKKRDD---------TFTYKAHILCGNLMLVEVIPKEPLSFSVFHY 387
Query: 945 AREEV-YIVQAPTPEIKAAWVNEIRKVLTSQLQACREASQHRALEQSQSLPLPAPTSTSP 1003
++ + VQA + + K WV +++++ A A +A+ + ++ P SP
Sbjct: 388 KNPKLQHTVQAKSQQDKRLWVLHLKRLILENHAAKIPAKAKQAILEMDAIHHPG-FCYSP 446
Query: 1004 SRGNSRNIKKLE-------ERKTDPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPE 1054
G E RK++P S S + K E + K S +P+
Sbjct: 447 EGGTKALFGSKEGSAPYRLRRKSEPSS-----RSHKVLKTSETAQDIQKVSREEGSPQ 499
>gi|58331253 obscurin, cytoskeletal calmodulin and titin-interacting
RhoGEF isoform a [Homo sapiens]
Length = 6620
Score = 128 bits (321), Expect = 4e-29
Identities = 92/340 (27%), Positives = 171/340 (50%), Gaps = 26/340 (7%)
Query: 639 SESRQGRGSAGEEEESLAILRRHVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLS 698
+E+ + G A E+E A L V+ ELL +E+A+VEEL + + ++ +
Sbjct: 5675 AEAPEFPGEAVSEDEYKARLSS-VIQELLSSEQAFVEELQFLQSHHLQHLERCPHVPIAV 5733
Query: 699 TGLHNKKDVLFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNK 758
G +K V+F N+ +I FH+ FL+EL+ D + V CF++ F+ Y ++ +
Sbjct: 5734 AG---QKAVIFRNVRDIGRFHSS-FLQELQQ-CDTDDDVAMCFIKNQAAFEQYLEFLVGR 5788
Query: 759 PRSESLWRQCSDCPFFQECQRKL--------DHKLSLDSYLLKPVQRITKYQLLLKEMLK 810
++ES+ + F+++ + L YL +PV+R+ +YQ LLKE+++
Sbjct: 5789 VQAESVVVSTAIQEFYKKYAEEALLAGDPSQPPPPPLQHYLEQPVERVQRYQALLKELIR 5848
Query: 811 Y-SRNCEGAEDLQEALSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDH 869
+RN + L++A + + + + + +H+ + Y G L LG+ + QG F VW
Sbjct: 5849 NKARNRQNCALLEQAYAVVSALPQRAENKLHVSLMENYPGTLQALGEPIRQGHFIVWEGA 5908
Query: 870 KRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGIT 929
+K RH+FL ++ CK R ++ SY ++ + ++++ +
Sbjct: 5909 PGARMP------WKGHNRHVFLFRNHLVICKPRRDS---RTDTVSYVFRNMMKLSSIDLN 5959
Query: 930 ENVKGDAKKFEIWYNAREEV--YIVQAPTPEIKAAWVNEI 967
+ V+GD + FE+W + V Y++QA T IK++WV EI
Sbjct: 5960 DQVEGDDRAFEVWQEREDSVRKYLLQARTAIIKSSWVKEI 5999
Score = 38.9 bits (89), Expect = 0.029
Identities = 44/165 (26%), Positives = 72/165 (43%), Gaps = 18/165 (10%)
Query: 1006 GNSRNIKKLEERKTDPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPEDDGGWSSAEEQ 1065
G ++KL + T+ +S + ++ A L P SKT + +P S+ Q
Sbjct: 5531 GTEEFLQKLTSQITEMVSAK--ITQAKLQVPGGDSDEDSKTPSA--SPRHGRSRPSSSIQ 5586
Query: 1066 INSSDAEEDGGLGPKKLVPGKYTVVADHEKGGP--DALRVRSGDVVELVQEGDEGLWYVR 1123
+SS++E+ G + Y V AD+ G DA+ +R G VE++ W VR
Sbjct: 5587 ESSSESEDGDARGE---IFDIYVVTADYLPLGAEQDAITLREGQYVEVLDAAHPLRWLVR 5643
Query: 1124 DPTT----GKEGWVPASSLS--VRLGPSGSAQCLSSSESSPGSAV 1162
T ++GWV + L ++L P A + + PG AV
Sbjct: 5644 TKPTKSSPSRQGWVSPAYLDRRLKLSPEWGA---AEAPEFPGEAV 5685
>gi|148833506 obscurin, cytoskeletal calmodulin and titin-interacting
RhoGEF isoform b [Homo sapiens]
Length = 7968
Score = 128 bits (321), Expect = 4e-29
Identities = 92/340 (27%), Positives = 171/340 (50%), Gaps = 26/340 (7%)
Query: 639 SESRQGRGSAGEEEESLAILRRHVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLS 698
+E+ + G A E+E A L V+ ELL +E+A+VEEL + + ++ +
Sbjct: 5675 AEAPEFPGEAVSEDEYKARLSS-VIQELLSSEQAFVEELQFLQSHHLQHLERCPHVPIAV 5733
Query: 699 TGLHNKKDVLFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNK 758
G +K V+F N+ +I FH+ FL+EL+ D + V CF++ F+ Y ++ +
Sbjct: 5734 AG---QKAVIFRNVRDIGRFHSS-FLQELQQ-CDTDDDVAMCFIKNQAAFEQYLEFLVGR 5788
Query: 759 PRSESLWRQCSDCPFFQECQRKL--------DHKLSLDSYLLKPVQRITKYQLLLKEMLK 810
++ES+ + F+++ + L YL +PV+R+ +YQ LLKE+++
Sbjct: 5789 VQAESVVVSTAIQEFYKKYAEEALLAGDPSQPPPPPLQHYLEQPVERVQRYQALLKELIR 5848
Query: 811 Y-SRNCEGAEDLQEALSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDH 869
+RN + L++A + + + + + +H+ + Y G L LG+ + QG F VW
Sbjct: 5849 NKARNRQNCALLEQAYAVVSALPQRAENKLHVSLMENYPGTLQALGEPIRQGHFIVWEGA 5908
Query: 870 KRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGIT 929
+K RH+FL ++ CK R ++ SY ++ + ++++ +
Sbjct: 5909 PGARMP------WKGHNRHVFLFRNHLVICKPRRDS---RTDTVSYVFRNMMKLSSIDLN 5959
Query: 930 ENVKGDAKKFEIWYNAREEV--YIVQAPTPEIKAAWVNEI 967
+ V+GD + FE+W + V Y++QA T IK++WV EI
Sbjct: 5960 DQVEGDDRAFEVWQEREDSVRKYLLQARTAIIKSSWVKEI 5999
Score = 38.9 bits (89), Expect = 0.029
Identities = 44/165 (26%), Positives = 72/165 (43%), Gaps = 18/165 (10%)
Query: 1006 GNSRNIKKLEERKTDPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPEDDGGWSSAEEQ 1065
G ++KL + T+ +S + ++ A L P SKT + +P S+ Q
Sbjct: 5531 GTEEFLQKLTSQITEMVSAK--ITQAKLQVPGGDSDEDSKTPSA--SPRHGRSRPSSSIQ 5586
Query: 1066 INSSDAEEDGGLGPKKLVPGKYTVVADHEKGGP--DALRVRSGDVVELVQEGDEGLWYVR 1123
+SS++E+ G + Y V AD+ G DA+ +R G VE++ W VR
Sbjct: 5587 ESSSESEDGDARGE---IFDIYVVTADYLPLGAEQDAITLREGQYVEVLDAAHPLRWLVR 5643
Query: 1124 DPTT----GKEGWVPASSLS--VRLGPSGSAQCLSSSESSPGSAV 1162
T ++GWV + L ++L P A + + PG AV
Sbjct: 5644 TKPTKSSPSRQGWVSPAYLDRRLKLSPEWGA---AEAPEFPGEAV 5685
>gi|188528641 SEC14 and spectrin domains 1 [Homo sapiens]
Length = 696
Score = 122 bits (307), Expect = 2e-27
Identities = 130/519 (25%), Positives = 227/519 (43%), Gaps = 57/519 (10%)
Query: 103 LKKRFAYLSGGRGQDGSPVITFPDYPAFSEIPDKEFQNVMTYLTSIPSLQDAGIGFILVI 162
LKK+ A+LSGG+ + ++T P + E + YL SIPS + GF +++
Sbjct: 10 LKKKLAFLSGGKDRRSGLILTIP--LCLEQTNMDELSVTLDYLLSIPSEKCKARGFTVIV 67
Query: 163 DRRRDKWTSVKASVLRIAASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRDDFKMKVPVI 222
D R+ +W VK V+ + PA + LV V++P F+ + ++ F +D +V
Sbjct: 68 DGRKSQWNVVKTVVVMLQNVVPAEVSLVCVVKPDEFWDKKVTHFCFWKEKDRLGFEV--- 124
Query: 223 MLSSVPDLHGYIDKSQLTEDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQMLQSFGTEL 282
+L S L YI+ QLTED GG+L Y H WL +R E F K++ +L
Sbjct: 125 ILVSANKLTRYIEPCQLTEDFGGSLTYDHMDWLNKRLVFEKF---TKESTSLLDELALIN 181
Query: 283 AETELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVN--- 339
++ N + SV + D L+ GH +L L++ + GS+ V+
Sbjct: 182 NGSDKGNQQEKERSV-----DLNFLPSVDPETVLQTGHELLSELQQRRFNGSDGGVSWSP 236
Query: 340 -QDQLDNQATVQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILDA-A 397
D+L Q V +LL L E + E + ++ QL +Q +V L+
Sbjct: 237 MDDELLAQPQVMKLLDSLREQYTRYQEVCRQRSKR----TQLEEIQQKVMQVVNWLEGPG 292
Query: 398 SQKIATFTDIGNSLAHVEHLLRDLASFE----EKSGVAVERARALSL-----DGEQLIGN 448
S+++ IG+S+ + L + E E V VE + ++ D E L+
Sbjct: 293 SEQLRAQWGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLV-- 350
Query: 449 KHYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCDEGIYLLASQ 508
++ Q+L +C + ++++ R+ LL +LE H + + D LL
Sbjct: 351 ------ELKSLQQQLSDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDG---LLGML 401
Query: 509 PVDKCQSQDGAEAALQEIEKFLETGAENKIQELNAIYKEYESILNQ------------DL 556
VD + DG A++Q+ K LE ++ L + ++ + +L+Q
Sbjct: 402 CVDVAPA-DG--ASIQQTLKLLEEKLKSVDVGLQGLREKGQGLLDQISNQASWAYGKDVT 458
Query: 557 MEHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPV 595
+E+ V Q ME++ R+Q + R+ + +Q V
Sbjct: 459 IENKENVDHIQGVMEDMQLRKQRCEDMVDVRRLKMLQMV 497
>gi|50843837 hypothetical protein LOC55701 [Homo sapiens]
Length = 1519
Score = 121 bits (304), Expect = 3e-27
Identities = 233/1055 (22%), Positives = 397/1055 (37%), Gaps = 180/1055 (17%)
Query: 101 DQLKKRFAYLSGGRGQDGSPVITF-PDYPAFSEIPDKEFQNV-MTYLTSI--PSLQDAGI 156
D + F L+GG Q G ++T P P P ++ N + YL S+ P LQ G+
Sbjct: 529 DLMASGFLILTGGVDQSGRALLTITPPCPPEEPPPSRDTLNTTLHYLHSLLRPDLQTLGL 588
Query: 157 GFILVIDRRRDKWTSVKASVLRIAASFP-ANLQLVLVLRPTG---FFQRTLSDIAFKFNR 212
+L LR A P A + + L+ +G QR L I
Sbjct: 589 SVLLD---------------LRQAPPLPPALIPALSQLQDSGDPPLVQRLLILI-----H 628
Query: 213 DDFKMKVPVIMLSSV---PDLHGYIDKSQLTEDLGGTLDYCHSRWLCQRTAIESFALMVK 269
DD ++ + V DL +L +LGG D S W+ + + +
Sbjct: 629 DDLPTELCGFQGAEVLSENDLKRVAKPEELQWELGGHRDPSPSHWV---EIHQEVVRLCR 685
Query: 270 QTAQMLQSFGTELAETELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLREL 329
+L S + E E + + +V +K A L ++G ++L LR
Sbjct: 686 LCQGVLGSVRQAIEELEGAAEPEEEEAVGMPKPLQKVLADPRLTALQRDGGAILMRLRST 745
Query: 330 QA---EGSEPSVNQDQLDNQATVQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQG 386
+ EG P+ ++D + +L+ N H Q+ EQ LR +Q
Sbjct: 746 PSSKLEGQGPATLYQEVDE--AIHQLVRLSN-----------LHVQQQEQRQCLRRLQQV 792
Query: 387 FREVKAILDAASQKIATFTDIGNSLAHVEHLLRDLASFEEKSGVAVERAR-ALSLDGEQL 445
+ + +++A+F G++L+ ++ +F + + +AR AL+L+ E
Sbjct: 793 LQWLSG---PGEEQLASFAMPGDTLSALQETELRFRAFSAEVQERLAQAREALALE-ENA 848
Query: 446 IGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCDEGIYLL 505
K + D F + + L ++L L R + + +W DEG L
Sbjct: 849 TSQK----------------VLDIFEQRLEQVESGLHRALRLQRFFQQAHEWVDEGFARL 892
Query: 506 ASQPVDKCQSQDGAEAALQEIE-KFLETGAENKIQELNAIYKEYESILN----------- 553
A + G EA L + + + QE+ A+ + S
Sbjct: 893 AG-------AGPGREAVLAALALRRAPEPSAGTFQEMRALALDLGSPAALREWGRCQARC 945
Query: 554 QDLMEHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPVA--------------PRP 599
Q+L +++ ++AS + RR+A Q P P P P
Sbjct: 946 QELERRIQQHVGEEASPRG-YRRRRADGASSGGAQWGPRSPSPSLSSLLLPSSPGPRPAP 1004
Query: 600 EALAKSPCPSPGIRRGSENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEESLAILR 659
+ +PC G E + G R R S R + E L R
Sbjct: 1005 SHCSLAPCGEDYEEEGPELAPEAEGRPPRAVLIRGLEVTSTEVVDRTCSPREHVLLGRAR 1064
Query: 660 -----------RHVMSELLDTERAYVEELLCVLEGYAAEMDNPLM--AHLLSTGLHNKKD 706
R + ++ V EL+ + Y A + P+ L+ L
Sbjct: 1065 GPDGPWGVGTPRMERKRSISAQQRLVSELIACEQDYVATLSEPVPPPGPELTPELRGTWA 1124
Query: 707 VLFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWR 766
E + FH FLREL+ P +G CFL + F +Y +Y +++ + E+
Sbjct: 1125 AALSARERLRSFHRTHFLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLENGLA 1184
Query: 767 QCSDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQ---E 823
S + ++ L L +P++++T+Y LL+E+L+ E +L
Sbjct: 1185 ALSPL-----SKGSMEAGPYLPRALQQPLEQLTRYGRLLEELLR-----EAGPELSSECR 1234
Query: 824 ALSSILGILKAV----NDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKEL 879
AL + + +L+ D + + A+ G + +L + G+LL + F+V K+
Sbjct: 1235 ALGAAVQLLREQEARGRDLLAVEAVRGCEIDLKEQGQLLHRDPFTVICGRKK-------- 1286
Query: 880 ARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKF 939
RH+FL E +LF K + G + + YKQ+ A +G+TEN+ F
Sbjct: 1287 -----CLRHVFLFEHLLLFSKLKGPEG----GSEMFVYKQAFKTADMGLTENIGDSGLCF 1337
Query: 940 EIWYNAR--EEVYIVQAPTPEIKAAWVNEIRKVLTSQLQACREASQHRALEQSQSLPLPA 997
E+W+ R E Y +QA +PEIK W + I ++L R+A+ ++ L Q +
Sbjct: 1338 ELWFRRRRAREAYTLQATSPEIKLKWTSSIAQLL------WRQAAHNKELRVQQMV---- 1387
Query: 998 PTSTSPSRGNS--RNIKKLEERKTDPL------SLEGYVSSAPLTKPPEKGKGWSKTSHS 1049
S GN +IK L ER L V+ + G S + S
Sbjct: 1388 ----SMGIGNKPFLDIKALGERTLSALLTGRAARTRASVAVSSFEHAGPSLPGLSPGACS 1443
Query: 1050 LEAPEDDGGWSSAEEQIN----SSDAEEDGGLGPK 1080
L A ++ W +QI+ + D+ D GP+
Sbjct: 1444 LPARVEEEAWDLDVKQISLAPETLDSSGDVSPGPR 1478
>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
exchange factor [Homo sapiens]
Length = 1386
Score = 119 bits (298), Expect = 2e-26
Identities = 133/475 (28%), Positives = 215/475 (45%), Gaps = 79/475 (16%)
Query: 662 VMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNR 721
V E+++TERAYV +L ++E Y + L +L + + LF N+E+IY F +
Sbjct: 106 VAREIVETERAYVRDLRSIVEDYLGPL---LDGGVLGLSVE-QVGTLFANIEDIYEFSSE 161
Query: 722 IFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCP----FFQEC 777
+ L +LEN + + CF++R EDF IY YC N P S +L R+ S P + QE
Sbjct: 162 L-LEDLENSSSAGG-IAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQER 219
Query: 778 QRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKY---SRNCEGAEDLQEALSSILGILKA 834
Q +L H L L S+LLKPVQRI KY LLL+E+ K+ G E ++EA+ S+ +
Sbjct: 220 QAQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWY 279
Query: 835 VND----SMHLIAIT-------GYDG-NLGDLGKLLMQGSFSVWTDHKRGHTKVKELARF 882
+ND H + G+ G L G+L+++G+F RG R
Sbjct: 280 INDMKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAF-------RGGGGGG--PRL 330
Query: 883 KPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIW 942
+ +R LFL + +L K+R G E Y+YK + + ++E+ + D F++
Sbjct: 331 RGGERLLFLFSRMLLVAKRR-----GLE----YTYKGHIFCCNLSVSESPR-DPLGFKVS 380
Query: 943 -YNAREEVYIVQAPTPEIKAAWVNEIRKVL---------TSQLQACREASQHRALEQSQS 992
+ +++QA E K W++ ++++ Q E S H A +
Sbjct: 381 DLTIPKHRHLLQAKNQEEKRLWIHCLQRLFFENHPASIPAKAKQVLLENSLHCAPKSKPV 440
Query: 993 L-----PLPAP-----TSTSPSRGNSR-----NIKKLEERKTDPLSLEGYVSSAPLTKPP 1037
L PL +P S +P R N+ ++ + R+++P+ + YV KP
Sbjct: 441 LEPLTPPLGSPRPRDARSFTPGRRNTAPSPGPSVIRRGRRQSEPVK-DPYVMFPQNAKPG 499
Query: 1038 EKGKGWSKTSHSLEAPEDDGGWSSAEEQINSSDAEEDGGLGPKKLVPGKYTVVAD 1092
K G + L PE S + + DA GP L P ++ +
Sbjct: 500 FKHAG---SEGELYPPESQPPVSGSAPPEDLEDA------GPPTLDPSGTSITEE 545
>gi|23308553 spermatogenesis associated 13 [Homo sapiens]
Length = 652
Score = 114 bits (285), Expect = 5e-25
Identities = 125/460 (27%), Positives = 202/460 (43%), Gaps = 98/460 (21%)
Query: 616 SENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRRHVMSELLDTERAYVE 675
SENSSS P E S+SR E+ +R +V+ E++DTER Y++
Sbjct: 211 SENSSST-------PSEEQDEEASQSRH------RHCENKQQMRTNVIREIMDTERVYIK 257
Query: 676 ELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDV--LFGNMEEIYHFHNRIFLRELENYTDC 733
L + EGY + TG+ + +FGN+E+IY F + FL++LE +
Sbjct: 258 HLRDICEGYIRQCRK-------HTGMFTVAQLATIFGNIEDIYKFQRK-FLKDLEKQYNK 309
Query: 734 PEL----VGRCFLERMEDFQIYEKYCQNKPRS----ESLWRQCSDCPFFQEC---QRKLD 782
E +G CFL+ E F IY +YC N P + +L +Q FF+ C Q+ +D
Sbjct: 310 EEPHLSEIGSCFLQNQEGFAIYSEYCNNHPGACLELANLMKQGKYRHFFEACRLLQQMID 369
Query: 783 HKLSLDSYLLKPVQRITKYQLLLKEMLKYS-------RNCEGAEDLQEALSSILGILKAV 835
+++D +LL PVQ+I KY L L E+LKY+ N + A + + ++ ++ K
Sbjct: 370 --IAIDGFLLTPVQKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACLINERKRK 427
Query: 836 NDSMHLIA-----ITGYDG--NLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRH 888
+S+ IA I G++G L +L+ G + T K+G K QR
Sbjct: 428 LESIDKIARWQVSIVGWEGLDILDRSSELIHSGELTKIT--KQG----------KSQQRT 475
Query: 889 LFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAK--------KFE 940
FL + ++ CKK + YK L+M + + + G K F+
Sbjct: 476 FFLFDHQLVSCKK------DLLRRDMLYYKGRLDMDEMELVDLGDGRDKDCNLSVKNAFK 529
Query: 941 IWYNAREEVYIVQAPTPEIKAAWVNEIRKVLTSQLQACREASQHRALEQSQSLPLPAPTS 1000
+ +EVY+ A E KA W LQAC A + R +++ + + +
Sbjct: 530 LVSRTTDEVYLFCAKKQEDKARW-----------LQAC--ADERRRVQEDKEMGMEISE- 575
Query: 1001 TSPSRGNSRNIKKLEERKTDPLSLEGYVSSAPLTKPPEKG 1040
N + + L +K +GY + P+ PP +G
Sbjct: 576 ------NQKKLAMLNAQKAGHGKSKGY-NRCPVA-PPHQG 607
Score = 35.0 bits (79), Expect = 0.42
Identities = 20/75 (26%), Positives = 37/75 (49%), Gaps = 2/75 (2%)
Query: 1092 DHEKGGPDALRVRSGDVVELVQEGDEGLWYVRDPTTGKEGWVPASSLSVRLGPSGSAQCL 1151
DH L ++GDV+++++ ++ W+ R + KE W PAS + +R+ ++
Sbjct: 157 DHVTMDDQELGFKAGDVIQVLEASNKDWWWGR--SEDKEAWFPASFVRLRVNQEELSENS 214
Query: 1152 SSSESSPGSAVLSNS 1166
SS+ S S S
Sbjct: 215 SSTPSEEQDEEASQS 229
>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
[Homo sapiens]
Length = 690
Score = 104 bits (260), Expect = 4e-22
Identities = 94/341 (27%), Positives = 163/341 (47%), Gaps = 44/341 (12%)
Query: 650 EEEESLAILRRHVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLF 709
E + S +R +V++E+L TER Y++ L + EGY + A + S + +F
Sbjct: 276 EAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRK--RADMFS---EEQLRTIF 330
Query: 710 GNMEEIYHFHNRIFLRELENY--TDCPEL--VGRCFLERMEDFQIYEKYCQNKPRS---- 761
GN+E+IY + F++ LE + P L +G CFLE DFQIY +YC N P +
Sbjct: 331 GNIEDIYRCQ-KAFVKALEQRFNRERPHLSELGACFLEHQADFQIYSEYCNNHPNACVEL 389
Query: 762 ESLWRQCSDCPFFQEC---QRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSR-NCEG 817
L + FF+ C Q+ +D +SLD +LL PVQ+I KY L L E+LKY+
Sbjct: 390 SRLTKLSKYVYFFEACRLLQKMID--ISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRD 447
Query: 818 AEDLQEALSSILGILKAVNDSM----HLIAITGYDGNLGDL--GKLLMQGSFSVWTDHKR 871
+D++ AL ++ + + +N+ ++ I + ++ D LL++ S +++
Sbjct: 448 FKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGEL- 506
Query: 872 GHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITEN 931
T+V + + K QR FL + +++CKK + YK L+M + + +
Sbjct: 507 --TRVTQ-PQAKSQQRMFFLFDHQLIYCKK------DLLRRDVLYYKGRLDMDGLEVVDL 557
Query: 932 VKGDAK--------KFEIWYNAREEVYIVQAPTPEIKAAWV 964
G + F + A + +++ PE K W+
Sbjct: 558 EDGKDRDLHVSIKNAFRLHRGATGDSHLLCTRKPEQKQRWL 598
Score = 35.4 bits (80), Expect = 0.32
Identities = 43/180 (23%), Positives = 70/180 (38%), Gaps = 20/180 (11%)
Query: 1001 TSPSRGN-SRNIKKLEERKTDPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPED--DG 1057
TSP N R L + L+ G+ P T P+ + + + + ED D
Sbjct: 108 TSPESLNLPRRSHPLSQSAPTGLNHMGWPEHTPGTAMPDGALDTAVCADEVGSEEDLYDD 167
Query: 1058 GWSSAEEQINSSDAEEDGGLGPKKLVPGKYTVVA----DHEKGGPDALRVRSGDVVELVQ 1113
SS+ + E L +L+ V A DH L ++GDV+E++
Sbjct: 168 LHSSSHHYSHPGGGGEQ--LAINELISDGSVVCAEALWDHVTMDDQELGFKAGDVIEVMD 225
Query: 1114 EGDEGLWYVRDPTTGKEGWVPASSLSVRLGPSGSAQCLSSSESSPGSAVLSNSSSCSEGG 1173
+ W+ R EGW PAS + +R ++ E + A L+ +S +GG
Sbjct: 226 ATNREWWWGR--VADGEGWFPASFVRLR---------VNQDEPADDDAPLAGNSGAEDGG 274
>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
[Homo sapiens]
Length = 670
Score = 104 bits (260), Expect = 4e-22
Identities = 94/341 (27%), Positives = 163/341 (47%), Gaps = 44/341 (12%)
Query: 650 EEEESLAILRRHVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLF 709
E + S +R +V++E+L TER Y++ L + EGY + A + S + +F
Sbjct: 276 EAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRK--RADMFS---EEQLRTIF 330
Query: 710 GNMEEIYHFHNRIFLRELENY--TDCPEL--VGRCFLERMEDFQIYEKYCQNKPRS---- 761
GN+E+IY + F++ LE + P L +G CFLE DFQIY +YC N P +
Sbjct: 331 GNIEDIYRCQ-KAFVKALEQRFNRERPHLSELGACFLEHQADFQIYSEYCNNHPNACVEL 389
Query: 762 ESLWRQCSDCPFFQEC---QRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSR-NCEG 817
L + FF+ C Q+ +D +SLD +LL PVQ+I KY L L E+LKY+
Sbjct: 390 SRLTKLSKYVYFFEACRLLQKMID--ISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRD 447
Query: 818 AEDLQEALSSILGILKAVNDSM----HLIAITGYDGNLGDL--GKLLMQGSFSVWTDHKR 871
+D++ AL ++ + + +N+ ++ I + ++ D LL++ S +++
Sbjct: 448 FKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGEL- 506
Query: 872 GHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITEN 931
T+V + + K QR FL + +++CKK + YK L+M + + +
Sbjct: 507 --TRVTQ-PQAKSQQRMFFLFDHQLIYCKK------DLLRRDVLYYKGRLDMDGLEVVDL 557
Query: 932 VKGDAK--------KFEIWYNAREEVYIVQAPTPEIKAAWV 964
G + F + A + +++ PE K W+
Sbjct: 558 EDGKDRDLHVSIKNAFRLHRGATGDSHLLCTRKPEQKQRWL 598
Score = 35.4 bits (80), Expect = 0.32
Identities = 43/180 (23%), Positives = 70/180 (38%), Gaps = 20/180 (11%)
Query: 1001 TSPSRGN-SRNIKKLEERKTDPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPED--DG 1057
TSP N R L + L+ G+ P T P+ + + + + ED D
Sbjct: 108 TSPESLNLPRRSHPLSQSAPTGLNHMGWPEHTPGTAMPDGALDTAVCADEVGSEEDLYDD 167
Query: 1058 GWSSAEEQINSSDAEEDGGLGPKKLVPGKYTVVA----DHEKGGPDALRVRSGDVVELVQ 1113
SS+ + E L +L+ V A DH L ++GDV+E++
Sbjct: 168 LHSSSHHYSHPGGGGEQ--LAINELISDGSVVCAEALWDHVTMDDQELGFKAGDVIEVMD 225
Query: 1114 EGDEGLWYVRDPTTGKEGWVPASSLSVRLGPSGSAQCLSSSESSPGSAVLSNSSSCSEGG 1173
+ W+ R EGW PAS + +R ++ E + A L+ +S +GG
Sbjct: 226 ATNREWWWGR--VADGEGWFPASFVRLR---------VNQDEPADDDAPLAGNSGAEDGG 274
>gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]
Length = 979
Score = 94.0 bits (232), Expect = 8e-19
Identities = 94/373 (25%), Positives = 163/373 (43%), Gaps = 56/373 (15%)
Query: 638 MSESRQG--RGSAGEEEESLAILRRHVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAH 695
MSE +G R + ++ E LR V+SEL TER YV L ++ + M+ +
Sbjct: 1 MSEDSRGDSRAESAKDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASK 60
Query: 696 LLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENYT----DCPELVGRCFLERMEDFQIY 751
+ +LF N+E+I H FL+ +E + + VG CFL + F+IY
Sbjct: 61 VDKNVTEETVKMLFSNIEDILAVHKE-FLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIY 119
Query: 752 EKYCQNKPRSESLWRQCSDC----PFFQECQRKLDHK---LSLDSYLLKPVQRITKYQLL 804
++YC N +++ L + + F C K + L+ YL+ P+QRI KY L+
Sbjct: 120 DEYCSNHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLI 179
Query: 805 LKEMLKYS-RNCEGAEDLQEALSSILGILKAVNDSMHLIA-----------ITGYDG-NL 851
LKE+LK + R + EAL ++ + +N++ + I G++G N+
Sbjct: 180 LKELLKRTPRKHSDYAAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNI 239
Query: 852 GD-LGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCK---KREENGE 907
D ++LM G + +++ +R FL + +++CK +R +N +
Sbjct: 240 TDTCTEMLMCG-------------VLLKISSGNIQERVFFLFDNLLVYCKRKHRRLKNSK 286
Query: 908 GYEKAPSYSYKQSLNMAAVGITENVKGDAKKF-----------EIWYNAREEVYIVQAPT 956
Y ++ +N + + ENV F +I A+ + ++ A T
Sbjct: 287 ASTDGHRYLFRGRINTEVMEV-ENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKT 345
Query: 957 PEIKAAWVNEIRK 969
PE K W I K
Sbjct: 346 PEEKHEWFEAILK 358
>gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]
Length = 1606
Score = 94.0 bits (232), Expect = 8e-19
Identities = 94/373 (25%), Positives = 163/373 (43%), Gaps = 56/373 (15%)
Query: 638 MSESRQG--RGSAGEEEESLAILRRHVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAH 695
MSE +G R + ++ E LR V+SEL TER YV L ++ + M+ +
Sbjct: 1 MSEDSRGDSRAESAKDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASK 60
Query: 696 LLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENYT----DCPELVGRCFLERMEDFQIY 751
+ +LF N+E+I H FL+ +E + + VG CFL + F+IY
Sbjct: 61 VDKNVTEETVKMLFSNIEDILAVHKE-FLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIY 119
Query: 752 EKYCQNKPRSESLWRQCSDC----PFFQECQRKLDHK---LSLDSYLLKPVQRITKYQLL 804
++YC N +++ L + + F C K + L+ YL+ P+QRI KY L+
Sbjct: 120 DEYCSNHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLI 179
Query: 805 LKEMLKYS-RNCEGAEDLQEALSSILGILKAVNDSMHLIA-----------ITGYDG-NL 851
LKE+LK + R + EAL ++ + +N++ + I G++G N+
Sbjct: 180 LKELLKRTPRKHSDYAAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNI 239
Query: 852 GD-LGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCK---KREENGE 907
D ++LM G + +++ +R FL + +++CK +R +N +
Sbjct: 240 TDTCTEMLMCG-------------VLLKISSGNIQERVFFLFDNLLVYCKRKHRRLKNSK 286
Query: 908 GYEKAPSYSYKQSLNMAAVGITENVKGDAKKF-----------EIWYNAREEVYIVQAPT 956
Y ++ +N + + ENV F +I A+ + ++ A T
Sbjct: 287 ASTDGHRYLFRGRINTEVMEV-ENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKT 345
Query: 957 PEIKAAWVNEIRK 969
PE K W I K
Sbjct: 346 PEEKHEWFEAILK 358
>gi|55749621 pleckstrin homology domain containing, family G, member 3
[Homo sapiens]
Length = 1163
Score = 92.4 bits (228), Expect = 2e-18
Identities = 73/277 (26%), Positives = 126/277 (45%), Gaps = 42/277 (15%)
Query: 746 EDFQIYEKYCQNKPRSESLWRQC----SDCPFFQECQRKLDHKLSLDSYLLKPVQRITKY 801
++F IY +YC N P S + +C FF++ Q L H L L SYLLKPVQRI KY
Sbjct: 119 QEFDIYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQHSLPLGSYLLKPVQRILKY 178
Query: 802 QLLLKEMLK-YSRNCEGAEDLQEALSSILGILKAVND------------SMHLIAITGYD 848
LLL+E+ K + +G E +++A+ ++ + +ND + + I
Sbjct: 179 HLLLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWKG 238
Query: 849 GNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEG 908
+L G+L+++G+F V H+ + +R FL +K +L KKR ++
Sbjct: 239 PDLTTYGELVLEGTFRV---HRVRN------------ERTFFLFDKTLLITKKRGDH--- 280
Query: 909 YEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNAREEVYIVQAPTPEIKAAWVNEIR 968
+ YK ++ +++ + E+ + Y ++ Y +QA T E K W + I+
Sbjct: 281 ------FVYKGNIPCSSLMLIESTRDSLCFTVTHYKHSKQQYSIQAKTVEEKRNWTHHIK 334
Query: 969 KVLTSQLQACREASQHRALEQSQSLPLPAPTSTSPSR 1005
+++ A A+ + S P SP R
Sbjct: 335 RLILENHHATIPQKAKEAILEMDSY-YPNRYRCSPER 370
>gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]
Length = 655
Score = 88.2 bits (217), Expect = 4e-17
Identities = 98/376 (26%), Positives = 158/376 (42%), Gaps = 66/376 (17%)
Query: 565 QKQASMEEVFHRRQASLKKLAARQTRPVQPVAPRPEALAKSPCPSPGIRRGS---ENSSS 621
+K AS+ + + S AA + + ++ V RPE P SPG R + E S
Sbjct: 7 EKLASVSNLVTVFENSRTPEAAPRGQRLEDVHHRPEC---RPPESPGPREKTNVGEAVGS 63
Query: 622 EGGALRRGPYRRAKSEMSESRQGR--------GSAGEEEESLAILRRHVMSELLDTERAY 673
E + R K+++S + GS +E E + ++ ELL+TE+AY
Sbjct: 64 EPRTVSRRYLNSLKNKLSSEAWRKSCQPVTLSGSGTQEPE------KKIVQELLETEQAY 117
Query: 674 VEELLCVLEGYAAEMDNPLMAHLLSTGLHNKK------DVLFGNMEEIYHFHNRIFL--- 724
V L +D LL T +K V+F N+ IY FH++ FL
Sbjct: 118 VARLHL--------LDQVFFQELLKTARSSKAFPEDVVRVIFSNISSIYQFHSQFFLPEL 169
Query: 725 -RELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSD-CPFFQECQRKLD 782
R L+++T P +G + ++Y +Y +N R+ L +D P FQE ++
Sbjct: 170 QRRLDDWTANPR-IGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKSPLFQEVLTRIQ 228
Query: 783 HK-----LSLDSYLLKPVQRITKYQLLLKEML-KYSRNCEGAEDLQEALSSILGI----- 831
L+L ++L+PVQRI +Y+LLLKE + K D Q+AL I
Sbjct: 229 SSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDMIFSAAQHSN 288
Query: 832 -----LKAVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQ 886
++ + D + G + ++ D L+ + G R PM+
Sbjct: 289 AAITEMERLQDLWEVYQRLGLEDDIVDPSNTLL----------REGPVLKISFRRNDPME 338
Query: 887 RHLFLHEKAVLFCKKR 902
R+LFL +L+C R
Sbjct: 339 RYLFLFNNMLLYCVPR 354
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.387
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,564,017
Number of Sequences: 37866
Number of extensions: 2368273
Number of successful extensions: 12273
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 104
Number of HSP's successfully gapped in prelim test: 332
Number of HSP's that attempted gapping in prelim test: 11287
Number of HSP's gapped (non-prelim): 1127
length of query: 1182
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1069
effective length of database: 13,968,660
effective search space: 14932497540
effective search space used: 14932497540
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.