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Search of human proteins with 16117781
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|16117781 F-box and WD repeat domain containing 7 isoform 1
[Homo sapiens]
(707 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 1447 0.0
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 1118 0.0
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 1117 0.0
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 241 1e-63
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 241 1e-63
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 241 1e-63
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 237 3e-62
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 237 3e-62
gi|32189425 WD repeat domain 69 [Homo sapiens] 184 3e-46
gi|16554629 WD repeat domain 5 [Homo sapiens] 169 6e-42
gi|16554627 WD repeat domain 5 [Homo sapiens] 169 6e-42
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 163 6e-40
gi|157266266 WD repeat domain 86 [Homo sapiens] 162 8e-40
gi|23199987 WD repeat domain 5B [Homo sapiens] 160 4e-39
gi|45594312 TNF receptor-associated factor 7 [Homo sapiens] 134 2e-31
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 130 3e-30
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 130 3e-30
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 125 1e-28
gi|110815834 F-box and WD-40 domain protein 10 [Homo sapiens] 125 1e-28
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 122 9e-28
gi|157694487 CMT1A duplicated region transcript 1 [Homo sapiens] 122 1e-27
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 121 2e-27
gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa... 120 4e-27
gi|21071067 TBP-associated factor 5 [Homo sapiens] 118 2e-26
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 116 6e-26
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 115 1e-25
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 114 2e-25
gi|26665869 WD repeat domain 51B [Homo sapiens] 114 4e-25
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 113 5e-25
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 113 5e-25
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 1447 bits (3747), Expect = 0.0
Identities = 707/707 (100%), Positives = 707/707 (100%)
Query: 1 MNQELLSVGSKRRRTGGSLRGNPSSSQVDEEQMNRVVEEEQQQQLRQQEEEHTARNGEVV 60
MNQELLSVGSKRRRTGGSLRGNPSSSQVDEEQMNRVVEEEQQQQLRQQEEEHTARNGEVV
Sbjct: 1 MNQELLSVGSKRRRTGGSLRGNPSSSQVDEEQMNRVVEEEQQQQLRQQEEEHTARNGEVV 60
Query: 61 GVEPRPGGQNDSQQGQLEENNNRFISVDEDSSGNQEEQEEDEEHAGEQDEEDEEEEEMDQ 120
GVEPRPGGQNDSQQGQLEENNNRFISVDEDSSGNQEEQEEDEEHAGEQDEEDEEEEEMDQ
Sbjct: 61 GVEPRPGGQNDSQQGQLEENNNRFISVDEDSSGNQEEQEEDEEHAGEQDEEDEEEEEMDQ 120
Query: 121 ESDDFDQSDDSSREDEHTHTNSVTNSSSIVDLPVHQLSSPFYTKTTKMKRKLDHGSEVRS 180
ESDDFDQSDDSSREDEHTHTNSVTNSSSIVDLPVHQLSSPFYTKTTKMKRKLDHGSEVRS
Sbjct: 121 ESDDFDQSDDSSREDEHTHTNSVTNSSSIVDLPVHQLSSPFYTKTTKMKRKLDHGSEVRS 180
Query: 181 FSLGKKPCKVSEYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRITSVQPPTGLQEWLKM 240
FSLGKKPCKVSEYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRITSVQPPTGLQEWLKM
Sbjct: 181 FSLGKKPCKVSEYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRITSVQPPTGLQEWLKM 240
Query: 241 FQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKD 300
FQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKD
Sbjct: 241 FQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKD 300
Query: 301 LLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKVIKPGFIHSPWKSAYIRQHR 360
LLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKVIKPGFIHSPWKSAYIRQHR
Sbjct: 301 LLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKVIKPGFIHSPWKSAYIRQHR 360
Query: 361 IDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGH 420
IDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGH
Sbjct: 361 IDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGH 420
Query: 421 TGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRD 480
TGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRD
Sbjct: 421 TGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRD 480
Query: 481 ATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGH 540
ATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGH
Sbjct: 481 ATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGH 540
Query: 541 TNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNAD 600
TNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNAD
Sbjct: 541 TNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNAD 600
Query: 601 STVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNL 660
STVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNL
Sbjct: 601 STVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNL 660
Query: 661 VTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVDMK 707
VTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVDMK
Sbjct: 661 VTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVDMK 707
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 1118 bits (2892), Expect = 0.0
Identities = 541/541 (100%), Positives = 541/541 (100%)
Query: 167 KMKRKLDHGSEVRSFSLGKKPCKVSEYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRIT 226
KMKRKLDHGSEVRSFSLGKKPCKVSEYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRIT
Sbjct: 87 KMKRKLDHGSEVRSFSLGKKPCKVSEYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRIT 146
Query: 227 SVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPK 286
SVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPK
Sbjct: 147 SVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPK 206
Query: 287 ELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKVIKPGF 346
ELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKVIKPGF
Sbjct: 207 ELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKVIKPGF 266
Query: 347 IHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVW 406
IHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVW
Sbjct: 267 IHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVW 326
Query: 407 SAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRC 466
SAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRC
Sbjct: 327 SAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRC 386
Query: 467 MHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVW 526
MHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVW
Sbjct: 387 MHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVW 446
Query: 527 DPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG 586
DPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG
Sbjct: 447 DPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG 506
Query: 587 MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTV 646
MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTV
Sbjct: 507 MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTV 566
Query: 647 KLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVDM 706
KLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVDM
Sbjct: 567 KLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVDM 626
Query: 707 K 707
K
Sbjct: 627 K 627
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 1117 bits (2889), Expect = 0.0
Identities = 540/541 (99%), Positives = 541/541 (100%)
Query: 167 KMKRKLDHGSEVRSFSLGKKPCKVSEYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRIT 226
+MKRKLDHGSEVRSFSLGKKPCKVSEYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRIT
Sbjct: 49 RMKRKLDHGSEVRSFSLGKKPCKVSEYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRIT 108
Query: 227 SVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPK 286
SVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPK
Sbjct: 109 SVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPK 168
Query: 287 ELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKVIKPGF 346
ELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKVIKPGF
Sbjct: 169 ELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKVIKPGF 228
Query: 347 IHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVW 406
IHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVW
Sbjct: 229 IHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVW 288
Query: 407 SAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRC 466
SAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRC
Sbjct: 289 SAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRC 348
Query: 467 MHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVW 526
MHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVW
Sbjct: 349 MHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVW 408
Query: 527 DPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG 586
DPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG
Sbjct: 409 DPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG 468
Query: 587 MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTV 646
MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTV
Sbjct: 469 MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTV 528
Query: 647 KLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVDM 706
KLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVDM
Sbjct: 529 KLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVDM 588
Query: 707 K 707
K
Sbjct: 589 K 589
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 241 bits (616), Expect = 1e-63
Identities = 139/445 (31%), Positives = 230/445 (51%), Gaps = 35/445 (7%)
Query: 238 LKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKE----LALYVL 293
+K F WS +++ ++ LI Q H+ ++P QRDFI+ LP++ +A +L
Sbjct: 77 IKYFDQWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFITALPEQGLDHIAENIL 136
Query: 294 SFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLH-------------IKRRK 340
S+L+ + L A C+ W+ + + +LW++ + +PL K R
Sbjct: 137 SYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQYLFKNRP 196
Query: 341 VIKP--GFIHSPWKSAYIRQHRIDTNWRRGELKSPKV-LKGHDDHVITCLQFCGNRIVSG 397
P F S + I++NWR G ++ + + + CLQ+ +I+SG
Sbjct: 197 TDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISG 256
Query: 398 SDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTL 457
DN++K+W + +CL+ L GHTG V Q + +I++GS+D T++VW+ TGE ++TL
Sbjct: 257 LRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTL 316
Query: 458 YGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCL---HVLMGHVAAVRCVQYDGRRV 514
H V + +V+ S+D ++ VWD+ + + VL+GH AAV V +D + +
Sbjct: 317 IHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYI 376
Query: 515 VSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCI 574
VS + D +KVW T + TL GH + LQ+ VVSGS D +IR+WD+E G C+
Sbjct: 377 VSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACL 436
Query: 575 HTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTG---------QCLQTLQGPNKHQS 625
L GH+ L + + +VSG D +K+WD++ CL+TL +H
Sbjct: 437 RVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLV---EHSG 493
Query: 626 AVTCLQFNKNFVITSSDDGTVKLWD 650
V LQF++ +I+SS D T+ +WD
Sbjct: 494 RVFRLQFDEFQIISSSHDDTILIWD 518
Score = 68.2 bits (165), Expect = 3e-11
Identities = 28/75 (37%), Positives = 49/75 (65%), Gaps = 3/75 (4%)
Query: 587 MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTV 646
++ D ++SG D+++KIWD + +CL+ L G H +V CLQ+++ ++T S D TV
Sbjct: 246 LQYDDEKIISGLRDNSIKIWDKTSLECLKVLTG---HTGSVLCLQYDERVIVTGSSDSTV 302
Query: 647 KLWDLKTGEFIRNLV 661
++WD+ TGE + L+
Sbjct: 303 RVWDVNTGEVLNTLI 317
Score = 33.5 bits (75), Expect = 0.70
Identities = 17/59 (28%), Positives = 34/59 (57%), Gaps = 4/59 (6%)
Query: 614 LQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVV 672
LQ +Q +++ V CLQ++ +I+ D ++K+WD + E ++ L +G +G V+
Sbjct: 230 LQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVL----TGHTGSVL 284
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 241 bits (616), Expect = 1e-63
Identities = 139/445 (31%), Positives = 230/445 (51%), Gaps = 35/445 (7%)
Query: 238 LKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKE----LALYVL 293
+K F WS +++ ++ LI Q H+ ++P QRDFI+ LP++ +A +L
Sbjct: 43 IKYFDQWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFITALPEQGLDHIAENIL 102
Query: 294 SFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLH-------------IKRRK 340
S+L+ + L A C+ W+ + + +LW++ + +PL K R
Sbjct: 103 SYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQYLFKNRP 162
Query: 341 VIKP--GFIHSPWKSAYIRQHRIDTNWRRGELKSPKV-LKGHDDHVITCLQFCGNRIVSG 397
P F S + I++NWR G ++ + + + CLQ+ +I+SG
Sbjct: 163 TDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISG 222
Query: 398 SDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTL 457
DN++K+W + +CL+ L GHTG V Q + +I++GS+D T++VW+ TGE ++TL
Sbjct: 223 LRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTL 282
Query: 458 YGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCL---HVLMGHVAAVRCVQYDGRRV 514
H V + +V+ S+D ++ VWD+ + + VL+GH AAV V +D + +
Sbjct: 283 IHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYI 342
Query: 515 VSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCI 574
VS + D +KVW T + TL GH + LQ+ VVSGS D +IR+WD+E G C+
Sbjct: 343 VSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACL 402
Query: 575 HTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTG---------QCLQTLQGPNKHQS 625
L GH+ L + + +VSG D +K+WD++ CL+TL +H
Sbjct: 403 RVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLV---EHSG 459
Query: 626 AVTCLQFNKNFVITSSDDGTVKLWD 650
V LQF++ +I+SS D T+ +WD
Sbjct: 460 RVFRLQFDEFQIISSSHDDTILIWD 484
Score = 68.2 bits (165), Expect = 3e-11
Identities = 28/75 (37%), Positives = 49/75 (65%), Gaps = 3/75 (4%)
Query: 587 MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTV 646
++ D ++SG D+++KIWD + +CL+ L G H +V CLQ+++ ++T S D TV
Sbjct: 212 LQYDDEKIISGLRDNSIKIWDKTSLECLKVLTG---HTGSVLCLQYDERVIVTGSSDSTV 268
Query: 647 KLWDLKTGEFIRNLV 661
++WD+ TGE + L+
Sbjct: 269 RVWDVNTGEVLNTLI 283
Score = 33.5 bits (75), Expect = 0.70
Identities = 17/59 (28%), Positives = 34/59 (57%), Gaps = 4/59 (6%)
Query: 614 LQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVV 672
LQ +Q +++ V CLQ++ +I+ D ++K+WD + E ++ L +G +G V+
Sbjct: 196 LQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVL----TGHTGSVL 250
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 241 bits (616), Expect = 1e-63
Identities = 139/445 (31%), Positives = 230/445 (51%), Gaps = 35/445 (7%)
Query: 238 LKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKE----LALYVL 293
+K F WS +++ ++ LI Q H+ ++P QRDFI+ LP++ +A +L
Sbjct: 64 IKYFDQWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFITALPEQGLDHIAENIL 123
Query: 294 SFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLH-------------IKRRK 340
S+L+ + L A C+ W+ + + +LW++ + +PL K R
Sbjct: 124 SYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQYLFKNRP 183
Query: 341 VIKP--GFIHSPWKSAYIRQHRIDTNWRRGELKSPKV-LKGHDDHVITCLQFCGNRIVSG 397
P F S + I++NWR G ++ + + + CLQ+ +I+SG
Sbjct: 184 TDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISG 243
Query: 398 SDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTL 457
DN++K+W + +CL+ L GHTG V Q + +I++GS+D T++VW+ TGE ++TL
Sbjct: 244 LRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTL 303
Query: 458 YGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCL---HVLMGHVAAVRCVQYDGRRV 514
H V + +V+ S+D ++ VWD+ + + VL+GH AAV V +D + +
Sbjct: 304 IHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYI 363
Query: 515 VSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCI 574
VS + D +KVW T + TL GH + LQ+ VVSGS D +IR+WD+E G C+
Sbjct: 364 VSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACL 423
Query: 575 HTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTG---------QCLQTLQGPNKHQS 625
L GH+ L + + +VSG D +K+WD++ CL+TL +H
Sbjct: 424 RVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLV---EHSG 480
Query: 626 AVTCLQFNKNFVITSSDDGTVKLWD 650
V LQF++ +I+SS D T+ +WD
Sbjct: 481 RVFRLQFDEFQIISSSHDDTILIWD 505
Score = 68.2 bits (165), Expect = 3e-11
Identities = 28/75 (37%), Positives = 49/75 (65%), Gaps = 3/75 (4%)
Query: 587 MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTV 646
++ D ++SG D+++KIWD + +CL+ L G H +V CLQ+++ ++T S D TV
Sbjct: 233 LQYDDEKIISGLRDNSIKIWDKTSLECLKVLTG---HTGSVLCLQYDERVIVTGSSDSTV 289
Query: 647 KLWDLKTGEFIRNLV 661
++WD+ TGE + L+
Sbjct: 290 RVWDVNTGEVLNTLI 304
Score = 33.5 bits (75), Expect = 0.70
Identities = 17/59 (28%), Positives = 34/59 (57%), Gaps = 4/59 (6%)
Query: 614 LQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVV 672
LQ +Q +++ V CLQ++ +I+ D ++K+WD + E ++ L +G +G V+
Sbjct: 217 LQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVL----TGHTGSVL 271
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 237 bits (604), Expect = 3e-62
Identities = 145/447 (32%), Positives = 231/447 (51%), Gaps = 37/447 (8%)
Query: 238 LKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKE----LALYVL 293
+K F+ WS +++ ++ LI Q H+ ++P QRDFI+ LP +A +L
Sbjct: 102 VKYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQRDFITALPARGLDHIAENIL 161
Query: 294 SFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLH---IKRRK------VIKP 344
S+L+ K L A C+ W + D +LW++ + + L +RR KP
Sbjct: 162 SYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWRGLAERRGWGQYLFKNKP 221
Query: 345 GFIHSPWKSAYIRQH--------RIDTNWRRGELKSPKV-LKGHDDHVITCLQFCGNRIV 395
++P S Y + I++NWR G ++ + + CLQ+ +IV
Sbjct: 222 PDGNAPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIV 281
Query: 396 SGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIH 455
SG DNT+K+W T +C R L GHTG V Q + +II+GS+D T++VW+ TGE ++
Sbjct: 282 SGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLN 341
Query: 456 TLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCL---HVLMGHVAAVRCVQYDGR 512
TL H V + + +V+ S+D ++ VWD+ + + VL+GH AAV V +D +
Sbjct: 342 TLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDK 401
Query: 513 RVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGN 572
+VS + D +KVW+ T + TL GH + LQ+ VVSGS D +IR+WD+E G
Sbjct: 402 YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGA 461
Query: 573 CIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTG---------QCLQTLQGPNKH 623
C+ L GH+ L + + +VSG D +K+WD+ CL+TL +H
Sbjct: 462 CLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLV---EH 518
Query: 624 QSAVTCLQFNKNFVITSSDDGTVKLWD 650
V LQF++ +++SS D T+ +WD
Sbjct: 519 SGRVFRLQFDEFQIVSSSHDDTILIWD 545
Score = 152 bits (385), Expect = 8e-37
Identities = 84/251 (33%), Positives = 138/251 (54%), Gaps = 17/251 (6%)
Query: 454 IHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRR 513
IH + V C+ ++++VSG RD T+++WD T +C +L GH +V C+QYD R
Sbjct: 260 IHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERV 319
Query: 514 VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNC 573
+++G+ D V+VWD T L+TL H V L+F+ +V+ S D SI VWD+ +
Sbjct: 320 IITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTD 379
Query: 574 I---HTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCL 630
I L GH++ + ++ D +VS + D T+K+W+ T + ++TL G H+ + CL
Sbjct: 380 ITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNG---HKRGIACL 436
Query: 631 QFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRN 690
Q+ V++ S D T++LWD++ G +R L G +V IR N ++V +
Sbjct: 437 QYRDRLVVSGSSDNTIRLWDIECGACLRVL-----EGHEELVRCIRFDNKRIV------S 485
Query: 691 GTEETKLLVLD 701
G + K+ V D
Sbjct: 486 GAYDGKIKVWD 496
Score = 32.7 bits (73), Expect = 1.2
Identities = 18/59 (30%), Positives = 31/59 (52%), Gaps = 4/59 (6%)
Query: 614 LQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVV 672
LQ + ++ V CLQ++ +++ D T+K+WD T E R L +G +G V+
Sbjct: 257 LQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRIL----TGHTGSVL 311
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 237 bits (604), Expect = 3e-62
Identities = 145/447 (32%), Positives = 231/447 (51%), Gaps = 37/447 (8%)
Query: 238 LKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKE----LALYVL 293
+K F+ WS +++ ++ LI Q H+ ++P QRDFI+ LP +A +L
Sbjct: 138 VKYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQRDFITALPARGLDHIAENIL 197
Query: 294 SFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLH---IKRRK------VIKP 344
S+L+ K L A C+ W + D +LW++ + + L +RR KP
Sbjct: 198 SYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWRGLAERRGWGQYLFKNKP 257
Query: 345 GFIHSPWKSAYIRQH--------RIDTNWRRGELKSPKV-LKGHDDHVITCLQFCGNRIV 395
++P S Y + I++NWR G ++ + + CLQ+ +IV
Sbjct: 258 PDGNAPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIV 317
Query: 396 SGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIH 455
SG DNT+K+W T +C R L GHTG V Q + +II+GS+D T++VW+ TGE ++
Sbjct: 318 SGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLN 377
Query: 456 TLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCL---HVLMGHVAAVRCVQYDGR 512
TL H V + + +V+ S+D ++ VWD+ + + VL+GH AAV V +D +
Sbjct: 378 TLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDK 437
Query: 513 RVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGN 572
+VS + D +KVW+ T + TL GH + LQ+ VVSGS D +IR+WD+E G
Sbjct: 438 YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGA 497
Query: 573 CIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTG---------QCLQTLQGPNKH 623
C+ L GH+ L + + +VSG D +K+WD+ CL+TL +H
Sbjct: 498 CLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLV---EH 554
Query: 624 QSAVTCLQFNKNFVITSSDDGTVKLWD 650
V LQF++ +++SS D T+ +WD
Sbjct: 555 SGRVFRLQFDEFQIVSSSHDDTILIWD 581
Score = 152 bits (385), Expect = 8e-37
Identities = 84/251 (33%), Positives = 138/251 (54%), Gaps = 17/251 (6%)
Query: 454 IHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRR 513
IH + V C+ ++++VSG RD T+++WD T +C +L GH +V C+QYD R
Sbjct: 296 IHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERV 355
Query: 514 VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNC 573
+++G+ D V+VWD T L+TL H V L+F+ +V+ S D SI VWD+ +
Sbjct: 356 IITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTD 415
Query: 574 I---HTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCL 630
I L GH++ + ++ D +VS + D T+K+W+ T + ++TL G H+ + CL
Sbjct: 416 ITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNG---HKRGIACL 472
Query: 631 QFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRN 690
Q+ V++ S D T++LWD++ G +R L G +V IR N ++V +
Sbjct: 473 QYRDRLVVSGSSDNTIRLWDIECGACLRVL-----EGHEELVRCIRFDNKRIV------S 521
Query: 691 GTEETKLLVLD 701
G + K+ V D
Sbjct: 522 GAYDGKIKVWD 532
Score = 32.7 bits (73), Expect = 1.2
Identities = 18/59 (30%), Positives = 31/59 (52%), Gaps = 4/59 (6%)
Query: 614 LQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVV 672
LQ + ++ V CLQ++ +++ D T+K+WD T E R L +G +G V+
Sbjct: 293 LQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRIL----TGHTGSVL 347
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 184 bits (466), Expect = 3e-46
Identities = 100/301 (33%), Positives = 172/301 (57%), Gaps = 17/301 (5%)
Query: 374 KVLKGHDDHVIT-CLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRD- 431
KVLK H + L G+ ++GS D T K+W +G+ L TL GH V++ +
Sbjct: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNP 145
Query: 432 --NIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWD 487
+ I +GS D+T K+W+ ETG+C HT GHT+ + C+ + + V +GS D T ++WD
Sbjct: 146 YGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWD 205
Query: 488 IETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 545
I+ G+ ++ L GH A + + ++ G R+++G++D V VWD +T ++ L GH +
Sbjct: 206 IQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEIS 265
Query: 546 SLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGH--QSLTSGMELKDNILVSGNADS 601
S F D +++GS+D + ++WD G C+ TLTGH + L S + ++ + +AD
Sbjct: 266 SASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADG 325
Query: 602 TVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVITSSDDGTVKLWDLKTGEFIRN 659
T +I+ T +C+ L+G H+ ++ + FN N ++T S D T ++WD +TG+ ++
Sbjct: 326 TARIFSAATRKCIAKLEG---HEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQV 382
Query: 660 L 660
L
Sbjct: 383 L 383
Score = 176 bits (447), Expect = 5e-44
Identities = 101/300 (33%), Positives = 163/300 (54%), Gaps = 19/300 (6%)
Query: 365 WRRGELKSPKVLKGHDDHVITCLQF---CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHT 421
W + L+GH + V+ + F G++I +GS D T K+WS TGKC T GHT
Sbjct: 119 WDTASGEELNTLEGHRN-VVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHT 177
Query: 422 GGV--WSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEK--RVVSG 477
+ S + ++ +GS D T K+W+ + GE ++TL GH++ + + + R+++G
Sbjct: 178 AEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITG 237
Query: 478 SRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLH 535
S D T+ VWD +TG+ +++L+GH A + + D +++G+ D K+WD C+
Sbjct: 238 SFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVA 297
Query: 536 TLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL--KD 591
TL GH + + FD G + + S D + R++ T CI L GH+ S + +
Sbjct: 298 TLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQG 357
Query: 592 NILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFN--KNFVITSSDDGTVKLW 649
N L++G++D T +IWD +TGQCLQ L+G H + FN N VIT S D T ++W
Sbjct: 358 NHLLTGSSDKTARIWDAQTGQCLQVLEG---HTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 108 bits (269), Expect = 2e-23
Identities = 60/175 (34%), Positives = 98/175 (56%), Gaps = 12/175 (6%)
Query: 496 VLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--- 550
VL H+ + V + G ++G+YD K+WD + L+TL+GH N VY++ F+
Sbjct: 87 VLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPY 146
Query: 551 GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMELKDNILVSGNADSTVKIWDI 608
G + +GS D + ++W VETG C HT GH + + + ++ +G+ D+T K+WDI
Sbjct: 147 GDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDI 206
Query: 609 KTGQCLQTLQGPNKHQSAVTCLQFNKNF--VITSSDDGTVKLWDLKTGEFIRNLV 661
+ G+ + TL+G H + + L FN + +IT S D TV +WD TG + L+
Sbjct: 207 QNGEEVYTLRG---HSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILI 258
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 169 bits (429), Expect = 6e-42
Identities = 98/284 (34%), Positives = 162/284 (57%), Gaps = 35/284 (12%)
Query: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV----WSSQMRDNIIISGSTDRTLKVW 446
G + S S D +K+W A GK +T+ GH G+ WSS N+++S S D+TLK+W
Sbjct: 57 GEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD--SNLLVSASDDKTLKIW 114
Query: 447 NAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWDIETGQCLHVLMGHVAAV 504
+ +G+C+ TL GH++ V C + + + +VSGS D ++R+WD++TG+CL L H V
Sbjct: 115 DVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPV 174
Query: 505 RCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYS-LQF--DGIHVVSGSL 559
V + DG +VS +YD + ++WD + CL TL N S ++F +G ++++ +L
Sbjct: 175 SAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATL 234
Query: 560 DTSIRVWDVETGNCIHTLTGHQ----------SLTSGMELKDNILVSGNADSTVKIWDIK 609
D ++++WD G C+ T TGH+ S+T G +VSG+ D+ V IW+++
Sbjct: 235 DNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGG-----KWIVSGSEDNLVYIWNLQ 289
Query: 610 TGQCLQTLQGPNKHQSAV--TCLQFNKNFVITSS--DDGTVKLW 649
T + +Q LQG H V T +N + +++ +D T+KLW
Sbjct: 290 TKEIVQKLQG---HTDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 145 bits (365), Expect = 2e-34
Identities = 85/261 (32%), Positives = 141/261 (54%), Gaps = 19/261 (7%)
Query: 416 TLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVR--CMHLHE 471
TL GHT V S + N + S S D+ +K+W A G+ T+ GH +
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 472 KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRR--VVSGAYDFMVKVWDPE 529
+VS S D TL++WD+ +G+CL L GH V C ++ + +VSG++D V++WD +
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159
Query: 530 TETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSL-TSG 586
T CL TL H++ V ++ F DG +VS S D R+WD +G C+ TL + S
Sbjct: 160 TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSF 219
Query: 587 MELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN-----FVIT 639
++ N +++ D+T+K+WD G+CL+T G H++ C+ N + ++++
Sbjct: 220 VKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG---HKNEKYCIFANFSVTGGKWIVS 276
Query: 640 SSDDGTVKLWDLKTGEFIRNL 660
S+D V +W+L+T E ++ L
Sbjct: 277 GSEDNLVYIWNLQTKEIVQKL 297
Score = 107 bits (267), Expect = 4e-23
Identities = 56/173 (32%), Positives = 99/173 (57%), Gaps = 11/173 (6%)
Query: 497 LMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGI 552
L GH AV V++ +G + S + D ++K+W T+ GH + + + D
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
Query: 553 HVVSGSLDTSIRVWDVETGNCIHTLTGHQSLT--SGMELKDNILVSGNADSTVKIWDIKT 610
+VS S D ++++WDV +G C+ TL GH + + N++VSG+ D +V+IWD+KT
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160
Query: 611 GQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDLKTGEFIRNLV 661
G+CL+TL H V+ + FN++ +++SS DG ++WD +G+ ++ L+
Sbjct: 161 GKCLKTLPA---HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLI 210
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 169 bits (429), Expect = 6e-42
Identities = 98/284 (34%), Positives = 162/284 (57%), Gaps = 35/284 (12%)
Query: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV----WSSQMRDNIIISGSTDRTLKVW 446
G + S S D +K+W A GK +T+ GH G+ WSS N+++S S D+TLK+W
Sbjct: 57 GEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD--SNLLVSASDDKTLKIW 114
Query: 447 NAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWDIETGQCLHVLMGHVAAV 504
+ +G+C+ TL GH++ V C + + + +VSGS D ++R+WD++TG+CL L H V
Sbjct: 115 DVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPV 174
Query: 505 RCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYS-LQF--DGIHVVSGSL 559
V + DG +VS +YD + ++WD + CL TL N S ++F +G ++++ +L
Sbjct: 175 SAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATL 234
Query: 560 DTSIRVWDVETGNCIHTLTGHQ----------SLTSGMELKDNILVSGNADSTVKIWDIK 609
D ++++WD G C+ T TGH+ S+T G +VSG+ D+ V IW+++
Sbjct: 235 DNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGG-----KWIVSGSEDNLVYIWNLQ 289
Query: 610 TGQCLQTLQGPNKHQSAV--TCLQFNKNFVITSS--DDGTVKLW 649
T + +Q LQG H V T +N + +++ +D T+KLW
Sbjct: 290 TKEIVQKLQG---HTDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 145 bits (365), Expect = 2e-34
Identities = 85/261 (32%), Positives = 141/261 (54%), Gaps = 19/261 (7%)
Query: 416 TLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVR--CMHLHE 471
TL GHT V S + N + S S D+ +K+W A G+ T+ GH +
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 472 KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRR--VVSGAYDFMVKVWDPE 529
+VS S D TL++WD+ +G+CL L GH V C ++ + +VSG++D V++WD +
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159
Query: 530 TETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSL-TSG 586
T CL TL H++ V ++ F DG +VS S D R+WD +G C+ TL + S
Sbjct: 160 TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSF 219
Query: 587 MELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN-----FVIT 639
++ N +++ D+T+K+WD G+CL+T G H++ C+ N + ++++
Sbjct: 220 VKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG---HKNEKYCIFANFSVTGGKWIVS 276
Query: 640 SSDDGTVKLWDLKTGEFIRNL 660
S+D V +W+L+T E ++ L
Sbjct: 277 GSEDNLVYIWNLQTKEIVQKL 297
Score = 107 bits (267), Expect = 4e-23
Identities = 56/173 (32%), Positives = 99/173 (57%), Gaps = 11/173 (6%)
Query: 497 LMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGI 552
L GH AV V++ +G + S + D ++K+W T+ GH + + + D
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
Query: 553 HVVSGSLDTSIRVWDVETGNCIHTLTGHQSLT--SGMELKDNILVSGNADSTVKIWDIKT 610
+VS S D ++++WDV +G C+ TL GH + + N++VSG+ D +V+IWD+KT
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160
Query: 611 GQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDLKTGEFIRNLV 661
G+CL+TL H V+ + FN++ +++SS DG ++WD +G+ ++ L+
Sbjct: 161 GKCLKTLPA---HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLI 210
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 163 bits (412), Expect = 6e-40
Identities = 99/291 (34%), Positives = 153/291 (52%), Gaps = 35/291 (12%)
Query: 394 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVW--SSQMRDNIIISGSTDRTLKVWNAETG 451
+VS S+D T+KVW TG RTL GHT V S ++ S S D T+K+W+ +
Sbjct: 123 MVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGF 182
Query: 452 ECIHTLYGHTSTVRCMHL--HEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQ- 508
ECI T++GH V + + + +VS SRD T+++W+++TG C+ GH VR V+
Sbjct: 183 ECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRP 242
Query: 509 -YDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF------------------ 549
DG + S + D V+VW T+ C L+ H + V + +
Sbjct: 243 NQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETK 302
Query: 550 ----DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKD--NILVSGNADSTV 603
G ++SGS D +I++WDV TG C+ TL GH + G+ ++S D T+
Sbjct: 303 KSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTL 362
Query: 604 KIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDLK 652
++WD K +C++TL N H+ VT L F+K +V+T S D TVK+W+ +
Sbjct: 363 RVWDYKNKRCMKTL---NAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410
Score = 137 bits (344), Expect = 4e-32
Identities = 84/267 (31%), Positives = 130/267 (48%), Gaps = 31/267 (11%)
Query: 374 KVLKGHDDHVITC-LQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN 432
+ LKGH D V G + S S D T+K+W +C+RT+ GH V S + N
Sbjct: 144 RTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPN 203
Query: 433 --IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDI 488
I+S S D+T+K+W +TG C+ T GH VR + ++ + S S D T+RVW +
Sbjct: 204 GDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVV 263
Query: 489 ETGQCLHVLMGHVAAVRCVQY----------------------DGRRVVSGAYDFMVKVW 526
T +C L H V C+ + G ++SG+ D +K+W
Sbjct: 264 ATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMW 323
Query: 527 DPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLT 584
D T CL TL GH N V + F G ++S + D ++RVWD + C+ TL H+
Sbjct: 324 DVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFV 383
Query: 585 SGMELKDN--ILVSGNADSTVKIWDIK 609
+ ++ +V+G+ D TVK+W+ +
Sbjct: 384 TSLDFHKTAPYVVTGSVDQTVKVWECR 410
Score = 134 bits (336), Expect = 4e-31
Identities = 83/260 (31%), Positives = 136/260 (52%), Gaps = 35/260 (13%)
Query: 432 NIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIE 489
++++S S D T+KVW+ ETG+ TL GHT +V+ + K + S S D T+++WD +
Sbjct: 121 SVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQ 180
Query: 490 TGQCLHVLMGH---VAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTN--RV 544
+C+ + GH V++V + +G +VS + D +K+W+ +T C+ T GH R+
Sbjct: 181 GFECIRTMHGHDHNVSSV-AIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRM 239
Query: 545 YSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQ-----------------SLTSGM 587
DG + S S D ++RVW V T C L H+ S +G
Sbjct: 240 VRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGS 299
Query: 588 ELKDN-----ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVITS 640
E K + L+SG+ D T+K+WD+ TG CL TL G H + V + F+ F+++
Sbjct: 300 ETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVG---HDNWVRGVLFHSGGKFILSC 356
Query: 641 SDDGTVKLWDLKTGEFIRNL 660
+DD T+++WD K ++ L
Sbjct: 357 ADDKTLRVWDYKNKRCMKTL 376
Score = 125 bits (315), Expect = 1e-28
Identities = 73/237 (30%), Positives = 122/237 (51%), Gaps = 33/237 (13%)
Query: 455 HTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD-- 510
+ L GH S V + H +VS S DAT++VWD ETG L GH +V+ + +D
Sbjct: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHS 161
Query: 511 GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDV 568
G+ + S + D +K+WD + C+ T+ GH + V S+ +G H+VS S D +I++W+V
Sbjct: 162 GKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEV 221
Query: 569 ETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSA 626
+TG C+ T TGH+ + + ++ S + D TV++W + T +C L+ +H+
Sbjct: 222 QTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELR---EHEHV 278
Query: 627 VTCLQFNKN----------------------FVITSSDDGTVKLWDLKTGEFIRNLV 661
V C+ + F+++ S D T+K+WD+ TG + LV
Sbjct: 279 VECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLV 335
>gi|157266266 WD repeat domain 86 [Homo sapiens]
Length = 376
Score = 162 bits (411), Expect = 8e-40
Identities = 91/286 (31%), Positives = 141/286 (49%), Gaps = 21/286 (7%)
Query: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAET 450
G R+++GS+D T ++WS G+C L GH V Q+ D + S D T++ W+ T
Sbjct: 27 GQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSADCTIRRWDVLT 86
Query: 451 GECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD 510
G+C+ GHTS V + + ++ S S D T RVW ++ GQ GH V + Y
Sbjct: 87 GQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYS 146
Query: 511 ----------------GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--GI 552
G +V+G+ D KVW + C TL+GHT V L D G
Sbjct: 147 APWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGH 206
Query: 553 HVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQ 612
+GS D +IR WD+ +G + H+ +EL + ++ SG+AD TVK W TG+
Sbjct: 207 TAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNRLVYSGSADRTVKCWLADTGE 266
Query: 613 CLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIR 658
C++T H+ V+ L+++ + T S D + +D ++GE R
Sbjct: 267 CVRTF---TAHRRNVSALKYHAGTLFTGSGDACARAFDAQSGELRR 309
Score = 151 bits (381), Expect = 2e-36
Identities = 85/306 (27%), Positives = 146/306 (47%), Gaps = 22/306 (7%)
Query: 365 WRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV 424
W + + +L+GH+ +V C Q + S D T++ W +TG+CL+ GHT V
Sbjct: 42 WSTADGQCCALLQGHESYVTFC-QLEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIV 100
Query: 425 WSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEK------------ 472
+ +N + S S DRT +VW+ + G+ GH + V +
Sbjct: 101 NRILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEA 160
Query: 473 ----RVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVW 526
+V+GS D T +VW + +G C L GH AV C+ D G +G+ D ++ W
Sbjct: 161 AAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAW 220
Query: 527 DPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG 586
D + L + H V L+ V SGS D +++ W +TG C+ T T H+ S
Sbjct: 221 DILSGEQLRVFREHRGSVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSA 280
Query: 587 MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTV 646
++ L +G+ D+ + +D ++G+ + +G H + C+Q + + T+S DG +
Sbjct: 281 LKYHAGTLFTGSGDACARAFDAQSGELRRVFRG---HTFIINCIQVHGQVLYTASHDGAL 337
Query: 647 KLWDLK 652
+LWD++
Sbjct: 338 RLWDVR 343
Score = 87.0 bits (214), Expect = 5e-17
Identities = 50/182 (27%), Positives = 84/182 (46%), Gaps = 21/182 (11%)
Query: 491 GQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQ 548
G L V H + + DG+R+++G+ D ++W C LQGH + V Q
Sbjct: 5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQ 64
Query: 549 FDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDI 608
+ + S D +IR WDV TG C+ GH S+ + + + +N L S + D T ++W +
Sbjct: 65 LEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSV 124
Query: 609 KTGQCLQTLQGPNKHQSAVTCLQFNK----------------NFVITSSDDGTVKLWDLK 652
GQ + +G H++ V L ++ ++T S DGT K+W +
Sbjct: 125 DKGQMSREFRG---HRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVA 181
Query: 653 TG 654
+G
Sbjct: 182 SG 183
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 160 bits (405), Expect = 4e-39
Identities = 96/299 (32%), Positives = 167/299 (55%), Gaps = 34/299 (11%)
Query: 376 LKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV----WSSQM 429
L GH + ++ ++F G + S S D + +W A GK +TL GH + WSS
Sbjct: 37 LVGHTE-AVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSD- 94
Query: 430 RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLH--EKRVVSGSRDATLRVWD 487
+ ++S S D+TLK+W+ +G+C+ TL GH++ V C + + ++SGS D T+++W+
Sbjct: 95 -SSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWE 153
Query: 488 IETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 545
++TG+CL L H V V ++ G +VSG+YD + ++WD + CL TL N
Sbjct: 154 VKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPV 213
Query: 546 S-LQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQ----------SLTSGMELKDN 592
S ++F +G ++++ +LD ++++WD G C+ T TGH+ S+T G
Sbjct: 214 SFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGG-----K 268
Query: 593 ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSS--DDGTVKLW 649
+VSG+ D+ V IW+++T + +Q LQG + C +N + +++ +D T+KLW
Sbjct: 269 WIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAAC-HPTENLIASAALENDKTIKLW 326
Score = 152 bits (384), Expect = 1e-36
Identities = 90/265 (33%), Positives = 144/265 (54%), Gaps = 21/265 (7%)
Query: 412 KCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVR--CM 467
KC TLVGHT V S + N + S S DR + +W A G+ TLYGH +
Sbjct: 34 KC--TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAW 91
Query: 468 HLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKV 525
R+VS S D TL++WD+ +G+CL L GH V C ++ ++SG++D VK+
Sbjct: 92 SSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKI 151
Query: 526 WDPETETCLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSL 583
W+ +T CL TL H++ V ++ F+ G +VSGS D R+WD +G C+ TL +
Sbjct: 152 WEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNP 211
Query: 584 -TSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFN-----KN 635
S ++ N +++ D+T+K+WD G+CL+T G H++ C+ N
Sbjct: 212 PVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTG---HKNEKYCIFANFSVTGGK 268
Query: 636 FVITSSDDGTVKLWDLKTGEFIRNL 660
++++ S+D V +W+L+T E ++ L
Sbjct: 269 WIVSGSEDNLVYIWNLQTKEIVQKL 293
Score = 147 bits (372), Expect = 3e-35
Identities = 87/259 (33%), Positives = 136/259 (52%), Gaps = 17/259 (6%)
Query: 365 WRRGELKSPKVLKGHDDHVI-TCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGG 423
W + K K L GH+ + +R+VS SDD TLK+W +GKCL+TL GH+
Sbjct: 68 WGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNY 127
Query: 424 VWSSQMR--DNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLH--EKRVVSGSR 479
V+ N+IISGS D T+K+W +TG+C+ TL H+ V +H + +VSGS
Sbjct: 128 VFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSY 187
Query: 480 DATLRVWDIETGQCLHVLM-GHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHT 536
D R+WD +GQCL L+ V V++ +G+ +++ D +K+WD CL T
Sbjct: 188 DGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKT 247
Query: 537 LQGHTNRVYSLQFD-----GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMEL 589
GH N Y + + G +VSGS D + +W+++T + L GH +++
Sbjct: 248 YTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHP 307
Query: 590 KDNILVSG--NADSTVKIW 606
+N++ S D T+K+W
Sbjct: 308 TENLIASAALENDKTIKLW 326
Score = 124 bits (312), Expect = 2e-28
Identities = 71/241 (29%), Positives = 124/241 (51%), Gaps = 8/241 (3%)
Query: 426 SSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL--HEKRVVSGSRDATL 483
S + + +S S +++ +V TL GHT V + + + + S S D +
Sbjct: 6 SRDAKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLI 65
Query: 484 RVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHT 541
+W G+ L GH + V + D R+VS + D +K+WD + CL TL+GH+
Sbjct: 66 IIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHS 125
Query: 542 NRVYSLQFDGIH--VVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK--DNILVSG 597
N V+ F+ ++SGS D ++++W+V+TG C+ TL+ H S + +++VSG
Sbjct: 126 NYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSG 185
Query: 598 NADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFI 657
+ D +IWD +GQCL+TL + + N +++T++ D T+KLWD G +
Sbjct: 186 SYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCL 245
Query: 658 R 658
+
Sbjct: 246 K 246
Score = 105 bits (261), Expect = 2e-22
Identities = 56/173 (32%), Positives = 96/173 (55%), Gaps = 11/173 (6%)
Query: 497 LMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGI 552
L+GH AV V++ +G + S + D ++ +W TL GH + + + D
Sbjct: 37 LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSS 96
Query: 553 HVVSGSLDTSIRVWDVETGNCIHTLTGHQSLT--SGMELKDNILVSGNADSTVKIWDIKT 610
+VS S D ++++WDV +G C+ TL GH + N+++SG+ D TVKIW++KT
Sbjct: 97 RLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKT 156
Query: 611 GQCLQTLQGPNKHQSAVTCLQFN--KNFVITSSDDGTVKLWDLKTGEFIRNLV 661
G+CL+TL H V+ + FN + +++ S DG ++WD +G+ ++ LV
Sbjct: 157 GKCLKTLSA---HSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLV 206
>gi|45594312 TNF receptor-associated factor 7 [Homo sapiens]
Length = 670
Score = 134 bits (338), Expect = 2e-31
Identities = 90/281 (32%), Positives = 143/281 (50%), Gaps = 15/281 (5%)
Query: 378 GHDDHV-ITCLQFCGNRIVSGSDDNTLKVW-SAVTGKCLRTLVGHTGGVWSSQMRDNIII 435
GH V C+ G+ + SGS D T+KVW + T KC +TL GH G V + ++ +
Sbjct: 394 GHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLY 453
Query: 436 SGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLH 495
SGS D T+ VW+ + + ++T+ H + V + + SGS A ++VWDI G L
Sbjct: 454 SGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSLKA-IKVWDI-VGTELK 511
Query: 496 V---LMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGI 552
+ L G VR + + SG+Y +K+WD T C+H LQ VYS+
Sbjct: 512 LKKELTGLNHWVRALVAAQSYLYSGSYQ-TIKIWDIRTLDCIHVLQTSGGSVYSIAVTNH 570
Query: 553 HVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL----KDNILVSGNADSTVKIWDI 608
H+V G+ + I VWD+E+ + TLTGH + + + S + D ++++W +
Sbjct: 571 HIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSM 630
Query: 609 KTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLW 649
C QTL +HQ +VT L ++ + + + D TVK+W
Sbjct: 631 DNMICTQTLL---RHQGSVTALAVSRGRLFSGAVDSTVKVW 668
Score = 89.7 bits (221), Expect = 8e-18
Identities = 68/217 (31%), Positives = 103/217 (47%), Gaps = 21/217 (9%)
Query: 492 QCLHVLMGHVAAV--RCVQYDGRRVVSGAYDFMVKVWDP-ETETCLHTLQGHTNRVYSLQ 548
+C +GH V CV G + SG+ D +KVWD T C TL+GH V +L
Sbjct: 387 KCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALC 446
Query: 549 FDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDI 608
G + SGS D +I VWD++ ++T+ H + + N+L SG+ + +K+WDI
Sbjct: 447 IQGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSLKA-IKVWDI 505
Query: 609 KTGQCL--QTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESG 666
+ + L G N A+ Q + S T+K+WD++T + I L T
Sbjct: 506 VGTELKLKKELTGLNHWVRALVAAQS----YLYSGSYQTIKIWDIRTLDCIHVLQT---- 557
Query: 667 GSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFD 703
SGG V+ I +N +VC GT E + V D +
Sbjct: 558 -SGGSVYSIAVTNHHIVC------GTYENLIHVWDIE 587
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 130 bits (328), Expect = 3e-30
Identities = 86/287 (29%), Positives = 138/287 (48%), Gaps = 18/287 (6%)
Query: 377 KGHDDHVITCLQFCGN--RIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN-- 432
KGH D +TC+ F N ++ SGS D+ L VW GH V +
Sbjct: 16 KGHRD-AVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74
Query: 433 IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIET 490
++ SGS D+T+++W HT+TVR +H + V+ S D T++VW
Sbjct: 75 LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134
Query: 491 GQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQ 548
+ L L H+ VRC ++ DGR +VS + D VK+WD + C+H+ H V +
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194
Query: 549 F--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVK 604
F G + + +D +++VWDV T + H + +G+ N L++ ++DST+K
Sbjct: 195 FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLK 254
Query: 605 IWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVITSSDDGTVKLW 649
I D+ G+ L TL G HQ T + F++ + + D V +W
Sbjct: 255 ILDLMEGRLLYTLHG---HQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 92.8 bits (229), Expect = 1e-18
Identities = 59/211 (27%), Positives = 106/211 (50%), Gaps = 13/211 (6%)
Query: 459 GHTSTVRCMH--LHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD--GRRV 514
GH V C+ ++ K++ SGS D+ L VW ++ + GH AV CV + G +
Sbjct: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76
Query: 515 VSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGN 572
SG+ D V++W P + + HT V S+ F DG V+ S D +++VW
Sbjct: 77 ASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQK 136
Query: 573 CIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCL 630
+ +L+ H + + + ++VS + D TVK+WD + +C+ + +H VT +
Sbjct: 137 FLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYC---EHGGFVTYV 193
Query: 631 QFNKN--FVITSSDDGTVKLWDLKTGEFIRN 659
F+ + + + D TVK+WD++T +++
Sbjct: 194 DFHPSGTCIAAAGMDNTVKVWDVRTHRLLQH 224
Score = 92.0 bits (227), Expect = 2e-18
Identities = 69/250 (27%), Positives = 115/250 (46%), Gaps = 19/250 (7%)
Query: 384 ITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGST 439
+ + FC G V+ SDD T+KVW+ K L +L H V ++ + +I+S S
Sbjct: 106 VRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASD 165
Query: 440 DRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWDIETGQCLHVL 497
D+T+K+W+ + EC+H+ H V + H + + D T++VWD+ T + L
Sbjct: 166 DKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY 225
Query: 498 MGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--GIH 553
H AAV + + G +++ + D +K+ D L+TL GH ++ F G +
Sbjct: 226 QLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEY 285
Query: 554 VVSGSLDTSIRVWD-----VETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDI 608
SG D + VW V+ G +L S M N+ VS + + + +
Sbjct: 286 FASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASSM---GNLTVS-ILEQRLTLTED 341
Query: 609 KTGQCLQTLQ 618
K QCL+ Q
Sbjct: 342 KLKQCLENQQ 351
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 130 bits (328), Expect = 3e-30
Identities = 86/287 (29%), Positives = 138/287 (48%), Gaps = 18/287 (6%)
Query: 377 KGHDDHVITCLQFCGN--RIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN-- 432
KGH D +TC+ F N ++ SGS D+ L VW GH V +
Sbjct: 16 KGHRD-AVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74
Query: 433 IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIET 490
++ SGS D+T+++W HT+TVR +H + V+ S D T++VW
Sbjct: 75 LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134
Query: 491 GQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQ 548
+ L L H+ VRC ++ DGR +VS + D VK+WD + C+H+ H V +
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194
Query: 549 F--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVK 604
F G + + +D +++VWDV T + H + +G+ N L++ ++DST+K
Sbjct: 195 FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLK 254
Query: 605 IWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVITSSDDGTVKLW 649
I D+ G+ L TL G HQ T + F++ + + D V +W
Sbjct: 255 ILDLMEGRLLYTLHG---HQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 92.8 bits (229), Expect = 1e-18
Identities = 59/211 (27%), Positives = 106/211 (50%), Gaps = 13/211 (6%)
Query: 459 GHTSTVRCMH--LHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD--GRRV 514
GH V C+ ++ K++ SGS D+ L VW ++ + GH AV CV + G +
Sbjct: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76
Query: 515 VSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGN 572
SG+ D V++W P + + HT V S+ F DG V+ S D +++VW
Sbjct: 77 ASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQK 136
Query: 573 CIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCL 630
+ +L+ H + + + ++VS + D TVK+WD + +C+ + +H VT +
Sbjct: 137 FLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYC---EHGGFVTYV 193
Query: 631 QFNKN--FVITSSDDGTVKLWDLKTGEFIRN 659
F+ + + + D TVK+WD++T +++
Sbjct: 194 DFHPSGTCIAAAGMDNTVKVWDVRTHRLLQH 224
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 125 bits (314), Expect = 1e-28
Identities = 89/294 (30%), Positives = 147/294 (50%), Gaps = 20/294 (6%)
Query: 374 KVLKGHDDHVITCLQFCGNR-IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSS--QMR 430
+V+ GH V GN+ V+GS D T+K+W +GK +L GH V R
Sbjct: 198 RVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTR 257
Query: 431 DNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWDI 488
+ S D+ +K W+ E + I +GH S V + LH +V+ SRD+T R+WD+
Sbjct: 258 SPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDV 317
Query: 489 ETGQCLHVLMGH---VAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 545
T +H L GH VA VRC Q ++++G++D +++WD TL H V
Sbjct: 318 RTKASVHTLSGHTNAVATVRC-QAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVR 376
Query: 546 SLQFDGIH--VVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL-KDNILVSGNADST 602
++ H SGS D +I+ W G+ I L+GH ++ + + + D +LVSG + T
Sbjct: 377 AVVLHPRHYTFASGSPD-NIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGT 435
Query: 603 VKIWDIKTGQCLQTLQ-----GPNKHQSAVTCLQF--NKNFVITSSDDGTVKLW 649
+ +WD +TG Q + G +S + F +++ ++T+ D T+K++
Sbjct: 436 MHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVY 489
Score = 123 bits (309), Expect = 5e-28
Identities = 79/254 (31%), Positives = 133/254 (52%), Gaps = 15/254 (5%)
Query: 412 KCLRTLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL 469
K R + GH G V + + ++GS DRT+K+W+ +G+ +L GH STVR + +
Sbjct: 195 KLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIV 254
Query: 470 HEKR--VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRR--VVSGAYDFMVKV 525
+ + S D ++ WD+E + + GH++AV + +V+ + D ++
Sbjct: 255 STRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARI 314
Query: 526 WDPETETCLHTLQGHTNRVYSLQFDGIH--VVSGSLDTSIRVWDVETGNCIHTLTGHQSL 583
WD T+ +HTL GHTN V +++ +++GS DT+IR+WD+ G TLT H+
Sbjct: 315 WDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKS 374
Query: 584 TSGMEL--KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITS- 640
+ L + SG+ D+ +K W G +Q L G H + + L N + V+ S
Sbjct: 375 VRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSG---HNAIINTLTVNSDGVLVSG 430
Query: 641 SDDGTVKLWDLKTG 654
+D+GT+ LWD +TG
Sbjct: 431 ADNGTMHLWDWRTG 444
Score = 108 bits (269), Expect = 2e-23
Identities = 71/242 (29%), Positives = 118/242 (48%), Gaps = 16/242 (6%)
Query: 459 GHTSTVRCMHLH--EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRR--V 514
GH VRC+ + + V+GS D T+++WD+ +G+ L GH++ VR V R +
Sbjct: 202 GHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYL 261
Query: 515 VSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIH--VVSGSLDTSIRVWDVETGN 572
S D VK WD E + GH + VY L +V+ S D++ R+WDV T
Sbjct: 262 FSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKA 321
Query: 573 CIHTLTGHQSLTSGMELK--DNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCL 630
+HTL+GH + + + + + +++G+ D+T+++WD+ G+ TL K AV
Sbjct: 322 SVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVL- 380
Query: 631 QFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRN 690
+++ S +K W G FI+NL G ++ + N+ V G+ N
Sbjct: 381 -HPRHYTFASGSPDNIKQWKFPDGSFIQNL-----SGHNAIINTLTV-NSDGVLVSGADN 433
Query: 691 GT 692
GT
Sbjct: 434 GT 435
Score = 85.9 bits (211), Expect = 1e-16
Identities = 53/166 (31%), Positives = 85/166 (51%), Gaps = 7/166 (4%)
Query: 496 VLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--G 551
V+ GH+ VRC+ + + V+G+ D +K+WD + +L GH + V +
Sbjct: 199 VISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRS 258
Query: 552 IHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNI--LVSGNADSTVKIWDIK 609
++ S D ++ WD+E I GH S G++L I LV+ + DST +IWD++
Sbjct: 259 PYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVR 318
Query: 610 TGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGE 655
T + TL G + V C Q + +IT S D T++LWDL G+
Sbjct: 319 TKASVHTLSGHTNAVATVRC-QAAEPQIITGSHDTTIRLWDLVAGK 363
>gi|110815834 F-box and WD-40 domain protein 10 [Homo sapiens]
Length = 1051
Score = 125 bits (314), Expect = 1e-28
Identities = 95/410 (23%), Positives = 178/410 (43%), Gaps = 52/410 (12%)
Query: 278 RDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAE-------------DNLLWREK 324
RDFI LP L+ Y+L L+ L + A ++W +A+ + + + +
Sbjct: 275 RDFIRYLPIHLSKYILRMLDRHTLNKCASVSQHWAAMAQQVKMDLSAHGFIQNQITFLQG 334
Query: 325 CKEEGIDEPLHIKRRKVIKPGFI---------HSPWKSAYIRQHRIDTNWRRGELKSPKV 375
GID P + + + P + H WK ++ + T ++ E + +
Sbjct: 335 SYTRGID-PNYANKVSIPVPKMVDDGKSMRVKHPKWKLRTKNEYNLWTAYQNEETQQVLI 393
Query: 376 LKGHDDHVITC-----------------LQFCGNRIVSGSDDNTLKVWSAVTGKCLRT-L 417
++ + C + + G +++ S + + + + K +
Sbjct: 394 ----EERNVFCGTYNVRILSDTWDQNRVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEF 449
Query: 418 VGHTGGVWSSQM--RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVV 475
GH G V + + +N ++SGS D +++ W+ ++G C GH T+ CM L + R+V
Sbjct: 450 RGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLV 509
Query: 476 SGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLH 535
SG RD ++VWD++TG+CL H + + + +VS +VKVW +
Sbjct: 510 SGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVK 568
Query: 536 TLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDV--ETGNCIHTLTGHQSLTSGMELKDNI 593
TL GH V L FD H++SGS D + W + + C+ H + L
Sbjct: 569 TLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWSMVGKYERCLMAFK-HPKEVLDVSLLFLR 627
Query: 594 LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVT-CLQFNKNFVITSSD 642
++S AD ++I++ G C++ L+ + ++ +Q N+ V T S+
Sbjct: 628 VISACADGKIRIYNFLNGNCMKVLKANGRGDPVLSFFIQGNRMVVNTESN 677
Score = 91.3 bits (225), Expect = 3e-18
Identities = 57/203 (28%), Positives = 100/203 (49%), Gaps = 17/203 (8%)
Query: 505 RCVQYDGRRVVSGAYDFMVKVWDP-ETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDT 561
R + Y G +++ + + + + D + + +GH V +L + ++SGS D
Sbjct: 416 RVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDL 475
Query: 562 SIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPN 621
SIR WD+++G C GHQ + M+L N LVSG D VK+WD+ TG+CL+T
Sbjct: 476 SIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTF---- 531
Query: 622 KHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGV------VWRI 675
+H+ + + N ++++S + G VK+W + + ++ L SG G V W +
Sbjct: 532 RHKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVKTL----SGHEGAVKCLFFDQWHL 587
Query: 676 RASNTKLVCAVGSRNGTEETKLL 698
+ +T + S G E L+
Sbjct: 588 LSGSTDGLVMAWSMVGKYERCLM 610
Score = 62.0 bits (149), Expect = 2e-09
Identities = 42/157 (26%), Positives = 74/157 (47%), Gaps = 23/157 (14%)
Query: 507 VQYDGRRVVSGAYDFMV--KVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIR 564
V + R V G Y+ + WD NRV + + G +++ S + I
Sbjct: 391 VLIEERNVFCGTYNVRILSDTWDQ-------------NRV--IHYSGGDLIAVSSNRKIH 435
Query: 565 VWDVETGNCIHT-LTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQCLQTLQGPN 621
+ D+ I GH + L ++N L+SG+ D +++ WD+K+G C + G
Sbjct: 436 LLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGG-- 493
Query: 622 KHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIR 658
HQ +TC+ KN +++ D VK+WD+ TG+ ++
Sbjct: 494 -HQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLK 529
>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
sapiens]
Length = 522
Score = 122 bits (307), Expect = 9e-28
Identities = 85/293 (29%), Positives = 137/293 (46%), Gaps = 26/293 (8%)
Query: 380 DDHVITCLQFCGNR--IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVW----------SS 427
DD I+ F N + + K+WS L TL GH V S
Sbjct: 230 DDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSL 289
Query: 428 QMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSR--DATLRV 485
+D + S + D ++K+W+ ++ E + + GHT V + H G+ D + R+
Sbjct: 290 DPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRL 349
Query: 486 WDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNR 543
WD+E + + GH V + + DG +G D +VWD T C+ L+GH
Sbjct: 350 WDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKE 409
Query: 544 VYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGME---LKDNILVSGN 598
+Y + F +G H+ +GS D + +VWD+ C++T+ HQ+L +G++ + N L++G
Sbjct: 410 IYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGA 469
Query: 599 ADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLW 649
D+T KIW L+TL G H+ V L + + + T S D T KLW
Sbjct: 470 YDNTAKIWTHPGWSPLKTLAG---HEGKVMGLDISSDGQLIATCSYDRTFKLW 519
Score = 78.2 bits (191), Expect = 2e-14
Identities = 48/179 (26%), Positives = 86/179 (48%), Gaps = 9/179 (5%)
Query: 400 DNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGS--TDRTLKVWNAETGECIHTL 457
D + ++W + + GH+ GV+ + ++G+ D +VW+ TG CI L
Sbjct: 344 DRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFL 403
Query: 458 YGHTSTVRCMHLHEK--RVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD---GR 512
GH + ++ + +GS D T +VWD+ +C++ + H V V+++ G
Sbjct: 404 EGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGN 463
Query: 513 RVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVE 569
+++GAYD K+W + L TL GH +V L DG + + S D + ++W E
Sbjct: 464 FLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE 522
Score = 73.9 bits (180), Expect = 5e-13
Identities = 59/231 (25%), Positives = 98/231 (42%), Gaps = 45/231 (19%)
Query: 444 KVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAA 503
K+W+ +HTL GH + V + H K VS L D+ C
Sbjct: 256 KLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVS------LDPKDVNLASC---------- 299
Query: 504 VRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDT 561
A D VK+W +++ + ++GHT RV + + G + + D
Sbjct: 300 --------------AADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDR 345
Query: 562 SIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQG 619
S R+WD+E I GH + + + +G D+ ++WD++TG+C+ L+G
Sbjct: 346 SWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEG 405
Query: 620 PNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDLKTGEFI------RNLVT 662
H + + F+ N + T S D T K+WDL+ + +NLVT
Sbjct: 406 ---HLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVT 453
Score = 54.7 bits (130), Expect = 3e-07
Identities = 31/104 (29%), Positives = 49/104 (47%), Gaps = 5/104 (4%)
Query: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTG---GVWSSQMRDNIIISGSTDRTLKVWN 447
G I +GS DNT KVW +C+ T+ H GV + N +++G+ D T K+W
Sbjct: 419 GYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWT 478
Query: 448 AETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIE 489
+ TL GH V + + + + + S D T ++W E
Sbjct: 479 HPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE 522
>gi|157694487 CMT1A duplicated region transcript 1 [Homo sapiens]
Length = 752
Score = 122 bits (306), Expect = 1e-27
Identities = 90/381 (23%), Positives = 170/381 (44%), Gaps = 43/381 (11%)
Query: 278 RDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAE-------------DNLLWREK 324
RDFI LP L+ Y+L L+ L + A ++W +A+ + + + +
Sbjct: 275 RDFIRYLPIHLSKYILRMLDRHTLNKCASVSQHWAAMAQQVKMDLSAHGFIQNQITFLQG 334
Query: 325 CKEEGIDEPLHIKRRKVIKPGFI---------HSPWKSAYIRQHRIDTNWRRGE-----L 370
GID P + + + P + H WK ++ + T ++ E +
Sbjct: 335 SYTRGID-PNYANKVSIPVPKMVDDGKSMRVKHPKWKLRTKNEYNLWTAYQNEETQQVLM 393
Query: 371 KSPKVLKG-HDDHVIT-------CLQFCGNRIVSGSDDNTLKVWSAVTGKCLRT-LVGHT 421
+ V G ++ +++ + + G +++ S + + + + K + GH
Sbjct: 394 EERNVFCGTYNVRILSDTWDQNRVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHA 453
Query: 422 GGVWSSQM--RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSR 479
G V + + +N ++SGS D +++ W+ ++G C GH T+ CM L + R+VSG R
Sbjct: 454 GSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGR 513
Query: 480 DATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQG 539
D ++VWD++TG+CL H + + + +VS +VKVW + TL G
Sbjct: 514 DCQVKVWDVDTGKCLKTFR-HKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSG 572
Query: 540 HTNRVYSLQFDGIHVVSGSLDTSIRVWDV--ETGNCIHTLTGHQSLTSGMELKDNILVSG 597
H V L FD H++SGS D + W + + C+ H + L ++S
Sbjct: 573 HEGAVKCLFFDQWHLLSGSTDGLVMAWSMVGKYERCLMAFK-HPKEVLDVSLLFLRVISA 631
Query: 598 NADSTVKIWDIKTGQCLQTLQ 618
AD ++I++ G C++ ++
Sbjct: 632 CADGKIRIYNFFNGNCMKVIK 652
Score = 91.3 bits (225), Expect = 3e-18
Identities = 57/203 (28%), Positives = 100/203 (49%), Gaps = 17/203 (8%)
Query: 505 RCVQYDGRRVVSGAYDFMVKVWDP-ETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDT 561
R + Y G +++ + + + + D + + +GH V +L + ++SGS D
Sbjct: 416 RVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDL 475
Query: 562 SIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPN 621
SIR WD+++G C GHQ + M+L N LVSG D VK+WD+ TG+CL+T
Sbjct: 476 SIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTF---- 531
Query: 622 KHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGV------VWRI 675
+H+ + + N ++++S + G VK+W + + ++ L SG G V W +
Sbjct: 532 RHKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVKTL----SGHEGAVKCLFFDQWHL 587
Query: 676 RASNTKLVCAVGSRNGTEETKLL 698
+ +T + S G E L+
Sbjct: 588 LSGSTDGLVMAWSMVGKYERCLM 610
Score = 90.1 bits (222), Expect = 6e-18
Identities = 55/184 (29%), Positives = 91/184 (49%), Gaps = 8/184 (4%)
Query: 362 DTNWRRGELKS---PKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLV 418
D + R +LKS ++ GH ITC+ C NR+VSG D +KVW TGKCL+T
Sbjct: 474 DLSIRYWDLKSGVCTRIFGGHQG-TITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTF- 531
Query: 419 GHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGS 478
H + ++++ D I+S +KVW+ + + TL GH V+C+ + ++SGS
Sbjct: 532 RHKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGS 591
Query: 479 RDATLRVWDIETGQCLHVLMG--HVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHT 536
D + W + G+ LM H V V RV+S D +++++ C+
Sbjct: 592 TDGLVMAWSM-VGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIRIYNFFNGNCMKV 650
Query: 537 LQGH 540
++ +
Sbjct: 651 IKAN 654
Score = 62.0 bits (149), Expect = 2e-09
Identities = 42/157 (26%), Positives = 74/157 (47%), Gaps = 23/157 (14%)
Query: 507 VQYDGRRVVSGAYDFMV--KVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIR 564
V + R V G Y+ + WD NRV + + G +++ S + I
Sbjct: 391 VLMEERNVFCGTYNVRILSDTWDQ-------------NRV--IHYSGGDLIAVSSNRKIH 435
Query: 565 VWDVETGNCIHT-LTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQCLQTLQGPN 621
+ D+ I GH + L ++N L+SG+ D +++ WD+K+G C + G
Sbjct: 436 LLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGG-- 493
Query: 622 KHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIR 658
HQ +TC+ KN +++ D VK+WD+ TG+ ++
Sbjct: 494 -HQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLK 529
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 121 bits (304), Expect = 2e-27
Identities = 66/217 (30%), Positives = 117/217 (53%), Gaps = 11/217 (5%)
Query: 414 LRTLVGHTGGVWS---SQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLH 470
L+ +V H V S + ++ +G D + +W+ CI +L GHTS V + L+
Sbjct: 13 LQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLN 72
Query: 471 --EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVW 526
E+ +V+GS+ ++RVWD+E + L LMGH A + + + G V SG+ D +K+W
Sbjct: 73 TPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLW 132
Query: 527 DPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLT 584
D + C+ +GH+ V L+F DG + S + D ++++WD+ G + GH
Sbjct: 133 DIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPV 192
Query: 585 SGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQG 619
+ +E N +L SG++D T++ WD++ Q + ++G
Sbjct: 193 NVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEG 229
Score = 116 bits (291), Expect = 6e-26
Identities = 63/197 (31%), Positives = 105/197 (53%), Gaps = 8/197 (4%)
Query: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNA 448
G + +G DD + +WS C+ +L GHT V S ++ + +I++GS +++VW+
Sbjct: 33 GRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDL 92
Query: 449 ETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRC 506
E + + TL GH + + + H + V SGS+D +++WDI C+ GH AVRC
Sbjct: 93 EAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRC 152
Query: 507 VQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTS 562
+++ DG+ + S A D VK+WD + GHT V ++F + + SGS D +
Sbjct: 153 LRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRT 212
Query: 563 IRVWDVETGNCIHTLTG 579
IR WD+E + + G
Sbjct: 213 IRFWDLEKFQVVSCIEG 229
Score = 102 bits (254), Expect = 1e-21
Identities = 61/210 (29%), Positives = 99/210 (47%), Gaps = 14/210 (6%)
Query: 454 IHTLYGHTSTVRCMHLHE---KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD 510
+ + H S V + L + + + +G D + +W I C+ L GH + V V+ +
Sbjct: 13 LQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLN 72
Query: 511 GRR--VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVW 566
+V+G+ ++VWD E L TL GH + SL F G V SGS DT+I++W
Sbjct: 73 TPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLW 132
Query: 567 DVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQ 624
D+ C+ GH + + L S D TVK+WD+ G+ + G H
Sbjct: 133 DIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPG---HT 189
Query: 625 SAVTCLQFNKN--FVITSSDDGTVKLWDLK 652
V ++F+ N + + S D T++ WDL+
Sbjct: 190 GPVNVVEFHPNEYLLASGSSDRTIRFWDLE 219
Score = 97.8 bits (242), Expect = 3e-20
Identities = 64/213 (30%), Positives = 109/213 (51%), Gaps = 17/213 (7%)
Query: 489 ETGQCLHVLMGHVAAVRCV---QYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 545
+T L ++ H + V + + GR + +G D V +W C+ +L GHT+ V
Sbjct: 8 KTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVE 67
Query: 546 SLQFDGIH--VVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK--DNILVSGNADS 601
S++ + +V+GS SIRVWD+E + TL GH++ ++ + SG+ D+
Sbjct: 68 SVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDT 127
Query: 602 TVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDLKTGEFIRN 659
+K+WDI+ C+ +G H AV CL+F+ + ++ +++DD TVKLWDL G+ +
Sbjct: 128 NIKLWDIRRKGCVFRYRG---HSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMS- 183
Query: 660 LVTLESGGSGGVVWRIRASNTKLVCAVGSRNGT 692
E G G V + + + A GS + T
Sbjct: 184 ----EFPGHTGPVNVVEFHPNEYLLASGSSDRT 212
Score = 95.9 bits (237), Expect = 1e-19
Identities = 57/188 (30%), Positives = 91/188 (48%), Gaps = 9/188 (4%)
Query: 394 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRD--NIIISGSTDRTLKVWNAETG 451
IV+GS +++VW K LRTL+GH + S + SGS D +K+W+
Sbjct: 78 IVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRK 137
Query: 452 ECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY 509
C+ GH+ VRC+ K + S + D T+++WD+ G+ + GH V V++
Sbjct: 138 GCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEF 197
Query: 510 DGRR--VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRV 565
+ SG+ D ++ WD E + ++G V S+ F DG + SG D S+RV
Sbjct: 198 HPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRV 256
Query: 566 WDVETGNC 573
+ E C
Sbjct: 257 YGWEPERC 264
Score = 74.3 bits (181), Expect = 4e-13
Identities = 53/174 (30%), Positives = 81/174 (46%), Gaps = 10/174 (5%)
Query: 365 WRRGELKSPKVLKGHDDHVITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTG 422
W K + L GH ++ + L F G + SGS D +K+W C+ GH+
Sbjct: 90 WDLEAAKILRTLMGHKANICS-LDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQ 148
Query: 423 GVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLH--EKRVVSGS 478
V + + + S + D T+K+W+ G+ + GHT V + H E + SGS
Sbjct: 149 AVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGS 208
Query: 479 RDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFM-VKVWDPE 529
D T+R WD+E Q + + G VR V + DG + SG D + V W+PE
Sbjct: 209 SDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWEPE 262
>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
sapiens]
Length = 472
Score = 120 bits (301), Expect = 4e-27
Identities = 89/300 (29%), Positives = 149/300 (49%), Gaps = 23/300 (7%)
Query: 374 KVLKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGG--VWSSQM 429
K+L GH+ V TC FC +++SGS D T+K+W V G +R V S
Sbjct: 96 KILSGHEHAVSTC-HFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSIT 154
Query: 430 RDNI-IISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE-KRVVSG-SRDATLRVW 486
D+ +I+ S D+T++ W+ ETG+ + + T V C + K VVSG D + +
Sbjct: 155 GDSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIM 214
Query: 487 DIETGQCLHVLMGHVA---AVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTL-QGHTN 542
D E + V+ H C D +RV S + D +K+WD ++ L T+ + H+N
Sbjct: 215 DAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSN 274
Query: 543 RVYS--LQFDGIHVVSGSLDTSIRVWDVETGN------CIHTLTGHQSLTSGMELK--DN 592
+ + F G + + S D ++++W+V TG C+ + GH+ S +
Sbjct: 275 AISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSS 334
Query: 593 ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLK 652
L+SG D TV IWD+ G +L+G N V + NK +++++S D T++LW+++
Sbjct: 335 FLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDV-AISNNKKWILSASKDRTMRLWNIE 393
Score = 96.7 bits (239), Expect = 7e-20
Identities = 78/261 (29%), Positives = 125/261 (47%), Gaps = 24/261 (9%)
Query: 415 RTLVGHTGGVWSSQ--MRDNIIISGSTDRTLKVWNAETGECIHTLYGHTST--VRCMHLH 470
+ L GH V + + D ++SGS D T+K+W+ G + V C
Sbjct: 96 KILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITG 155
Query: 471 EK-RVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRC-VQYDGRRVVSGA-YDFMVKVWD 527
+ RV++ S D T+R WD+ETG+ L + V C DG+ VVSG D + + D
Sbjct: 156 DSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMD 215
Query: 528 PETETCLHTLQGH-TNRVYSLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLT-GHQSL 583
E T + ++ H T + S FD V S SLD I++WDV + + T+T H +
Sbjct: 216 AENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNA 275
Query: 584 TSG--MELKDNILVSGNADSTVKIWDIKTGQ------CLQTLQGPNKHQSAVTCLQF--N 633
S + L + + D +KIW++ TG+ C+ +QG H+ +V+ F +
Sbjct: 276 ISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQG---HEGSVSSCHFARD 332
Query: 634 KNFVITSSDDGTVKLWDLKTG 654
+F+I+ D TV +WD+ G
Sbjct: 333 SSFLISGGFDRTVAIWDVAEG 353
Score = 91.7 bits (226), Expect = 2e-18
Identities = 74/229 (32%), Positives = 116/229 (50%), Gaps = 16/229 (6%)
Query: 457 LYGHTSTVRCMH--LHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAA--VRC-VQYDG 511
L GH V H + + +++SGS D T+++WD G + A V C + D
Sbjct: 98 LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDS 157
Query: 512 RRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSG-SLDTSIRVWDV 568
RV++ +YD V+ WD ET L ++ T + S +F DG +VVSG +D I + D
Sbjct: 158 SRVIAASYDKTVRAWDLETGKLLWKVRYDTF-IVSCKFSPDGKYVVSGFDVDHGICIMDA 216
Query: 569 ETGNCIHTLTGH--QSLTSGMELKDNILVSG-NADSTVKIWDIKTGQCLQTLQGPNKHQS 625
E + + H +S+TS D+ V+ + D +KIWD+ + L T+ + +
Sbjct: 217 ENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAI 276
Query: 626 AVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRN---LVTLESGGSGGV 671
+ C F+ +F+ TSS D +K+W++ TGEF RN VTL G G V
Sbjct: 277 SNCCFTFSGHFLCTSSWDKNLKIWNVHTGEF-RNCGACVTLMQGHEGSV 324
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 118 bits (295), Expect = 2e-26
Identities = 75/227 (33%), Positives = 116/227 (51%), Gaps = 19/227 (8%)
Query: 374 KVLKGHDDHVITCLQFCGNR--IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR- 430
K+L GH V F +R ++S S+D T+++WS T CL GH VW +Q
Sbjct: 537 KILYGHSGPVYGA-SFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSP 595
Query: 431 -DNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLH--EKRVVSGSRDATLRVWD 487
+SG DR ++W + + + GH + V C H V +GS D T+R+WD
Sbjct: 596 YGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWD 655
Query: 488 IETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 545
+ G C+ + GH + + + +GR + +GA D V +WD + L+GHT+ V
Sbjct: 656 VLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVC 715
Query: 546 SLQF--DGIHVVSGSLDTSIRVW-------DVETGNCIHTLTGHQSL 583
SL+F DG + SGS+D ++R+W D+ET + T TGH +L
Sbjct: 716 SLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDD-FTTATGHINL 761
Score = 117 bits (293), Expect = 4e-26
Identities = 84/268 (31%), Positives = 130/268 (48%), Gaps = 24/268 (8%)
Query: 394 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTL-KVWNAETGE 452
I G D+T++VWS VT K LR++ Q D +I +D L ++ + +T
Sbjct: 485 IAGGFADSTVRVWS-VTPKKLRSV---------KQASDLSLIDKESDDVLERIMDEKTAS 534
Query: 453 CIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD 510
+ LYGH+ V R ++S S D T+R+W ++T CL GH V Q+
Sbjct: 535 ELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFS 594
Query: 511 --GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVW 566
G VSG +D + ++W + L GH V +F + +V +GS D ++R+W
Sbjct: 595 PYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLW 654
Query: 567 DVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQ 624
DV GNC+ TGH+ + N L +G D V +WDI G + L+G H
Sbjct: 655 DVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKG---HT 711
Query: 625 SAVTCLQFNKN--FVITSSDDGTVKLWD 650
V L+F+++ + + S D TV+LWD
Sbjct: 712 DTVCSLRFSRDGEILASGSMDNTVRLWD 739
Score = 97.8 bits (242), Expect = 3e-20
Identities = 80/290 (27%), Positives = 132/290 (45%), Gaps = 27/290 (9%)
Query: 413 CLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLH 470
C T + G+ + + D+ +I G D T++VW+ T + + ++ + + L
Sbjct: 462 CFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSV-TPKKLRSVKQASD----LSLI 516
Query: 471 EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDP 528
+K S D R+ D +T L +L GH V + D ++S + D V++W
Sbjct: 517 DKE----SDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSL 572
Query: 529 ETETCLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG 586
+T TCL +GH V+ QF G + VSG D R+W + + GH + +
Sbjct: 573 QTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNC 632
Query: 587 MEL--KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSD 642
N + +G+AD TV++WD+ G C++ G H+ + L F+ N F+ T +
Sbjct: 633 TRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTG---HKGPIHSLTFSPNGRFLATGAT 689
Query: 643 DGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGT 692
DG V LWD+ G L+ E G V +R S + A GS + T
Sbjct: 690 DGRVLLWDIGHG-----LMVGELKGHTDTVCSLRFSRDGEILASGSMDNT 734
Score = 69.3 bits (168), Expect = 1e-11
Identities = 98/467 (20%), Positives = 178/467 (38%), Gaps = 56/467 (11%)
Query: 33 MNRVVEEEQQQQLRQQEEEHTARNGEVVGVEPRPGGQNDSQQGQLEENNNRFISVDEDSS 92
+ R ++E+Q Q+ +EH ++ PR Q D+ G L R + +
Sbjct: 317 LKRHLQEKQNNQIWNIVQEHLYI--DIFDGMPRSKQQIDAMVGSLAGEAKREANKSKVFF 374
Query: 93 GNQEEQEEDEEHAGEQDEEDEEEEEMDQESDDFDQSDDSSREDEHTHTNSVTNSSSIVDL 152
G +E E E ++DEE E EE ++ S S + + +
Sbjct: 375 GLLKEPEI-EVPLDDEDEEGENEEGKPKKKKPKKDSIGSKSKKQDPNAP----------- 422
Query: 153 PVHQLSSPFYTKTTKMKRKLDHGSEVRSFSLGKKPC-KVSEYTSTTGLVPCSATPTTFGD 211
P +++ P + K+ + ++ + LG + YT +A T
Sbjct: 423 PQNRIPLPELKDSDKLDKIMNMKETTKRVRLGPDCLPSICFYTFLNAYQGLTAVDVTDDS 482
Query: 212 LRAANGQGQQRRRITSVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQV 271
A G R+ SV P K +S L +D+ D + ++
Sbjct: 483 SLIAGGFADSTVRVWSVTP--------KKLRSVKQASDLSLIDKESDDV-------LERI 527
Query: 272 IEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQ---TCRYWRILAEDNLLWREKCKEE 328
++ + + L +Y SF ++ L ++ T R W + L+ +
Sbjct: 528 MDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYK----- 582
Query: 329 GIDEPLHIKRRKVIKPGFIHSPWKSAYIR--QHRIDTNWRRGELKSPKVLKGHDDHVITC 386
G + P+ + SP+ ++ R+ W + ++ GH V C
Sbjct: 583 GHNYPVWDTQ---------FSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADV-NC 632
Query: 387 LQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRT 442
+F N + +GS D T+++W + G C+R GH G + S N + +G+TD
Sbjct: 633 TRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGR 692
Query: 443 LKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWD 487
+ +W+ G + L GHT TV + + + SGS D T+R+WD
Sbjct: 693 VLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 116 bits (291), Expect = 6e-26
Identities = 75/262 (28%), Positives = 123/262 (46%), Gaps = 15/262 (5%)
Query: 400 DNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTL 457
D+ L VW GH V + ++ SGS D+T+++W
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
Query: 458 YGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRR 513
HT+TVR +H + V+ S D T++VW + L L H+ VRC ++ DGR
Sbjct: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121
Query: 514 VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETG 571
+VS + D VK+WD + C+H+ H V + F G + + +D +++VWDV T
Sbjct: 122 IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTH 181
Query: 572 NCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTC 629
+ H + +G+ N L++ ++DST+KI D+ G+ L TL G HQ T
Sbjct: 182 RLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHG---HQGPATT 238
Query: 630 LQFNK--NFVITSSDDGTVKLW 649
+ F++ + + D V +W
Sbjct: 239 VAFSRTGEYFASGGSDEQVMVW 260
Score = 106 bits (264), Expect = 8e-23
Identities = 70/241 (29%), Positives = 113/241 (46%), Gaps = 13/241 (5%)
Query: 378 GHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--I 433
GH D +TC+ F G+ + SGS D T+++W HT V S +
Sbjct: 21 GHKD-AVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQS 79
Query: 434 IISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETG 491
++ S D+T+KVW + + +L H + VRC + +VS S D T+++WD +
Sbjct: 80 FVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR 139
Query: 492 QCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF 549
+C+H H V V + G + + D VKVWD T L Q H+ V L F
Sbjct: 140 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 199
Query: 550 --DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQ--SLTSGMELKDNILVSGNADSTVKI 605
G ++++ S D+++++ D+ G ++TL GHQ + T SG +D V +
Sbjct: 200 HPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 259
Query: 606 W 606
W
Sbjct: 260 W 260
Score = 79.7 bits (195), Expect = 8e-15
Identities = 51/188 (27%), Positives = 93/188 (49%), Gaps = 11/188 (5%)
Query: 480 DATLRVWDIETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLHTL 537
D+ L VW ++ + GH AV CV + G + SG+ D V++W P +
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
Query: 538 QGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--I 593
+ HT V S+ F DG V+ S D +++VW + +L+ H + + + +
Sbjct: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121
Query: 594 LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDL 651
+VS + D TVK+WD + +C+ + +H VT + F+ + + + D TVK+WD+
Sbjct: 122 IVSASDDKTVKLWDKSSRECVHSYC---EHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 178
Query: 652 KTGEFIRN 659
+T +++
Sbjct: 179 RTHRLLQH 186
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 115 bits (288), Expect = 1e-25
Identities = 85/311 (27%), Positives = 149/311 (47%), Gaps = 28/311 (9%)
Query: 366 RRGELKSP-KVLKGHDDHVITC-LQFCGNRIVSGSDDNTLKVWSAVTGKC--LRTLVGHT 421
R L++P +L GH+ V C G+ + S D + +W+ V G C TL GH+
Sbjct: 51 RCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWN-VYGDCDNYATLKGHS 109
Query: 422 GGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEK---RVVS 476
G V + ++ S STD+T+ VW++ETGE + L GHTS V + + V +
Sbjct: 110 GAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCT 169
Query: 477 GSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD-GRRVVSGAYDFMVKVWDPETETCLH 535
GS D T+++WDI + + D +++SG D +KVWD +
Sbjct: 170 GSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTY 229
Query: 536 TLQGHTNRV--YSLQFDGIHVVSGSLDTSIRVWDVE----TGNCIHTLTGH------QSL 583
T++GH + V SL +G +++S ++D ++RVWDV C+ G+ L
Sbjct: 230 TMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLL 289
Query: 584 TSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSS 641
+ + +G+AD V +WD + + L L G H ++ + F+ + +I++S
Sbjct: 290 RCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPG---HAGSINEVAFHPDEPIIISAS 346
Query: 642 DDGTVKLWDLK 652
D + + +++
Sbjct: 347 SDKRLYMGEIQ 357
Score = 38.5 bits (88), Expect = 0.022
Identities = 29/93 (31%), Positives = 46/93 (49%), Gaps = 10/93 (10%)
Query: 574 IHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQC--LQTLQGPNKHQSAVTC 629
I L+GH+ + N L S D + +W++ G C TL+G H AV
Sbjct: 59 IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY-GDCDNYATLKG---HSGAVME 114
Query: 630 LQFNKN--FVITSSDDGTVKLWDLKTGEFIRNL 660
L +N + + ++S D TV +WD +TGE ++ L
Sbjct: 115 LHYNTDGSMLFSASTDKTVAVWDSETGERVKRL 147
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 114 bits (286), Expect = 2e-25
Identities = 74/280 (26%), Positives = 130/280 (46%), Gaps = 21/280 (7%)
Query: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM--RDNIIISGSTDRTLKVWNA 448
G + +GS D ++W+ G TL H G +++ + + N I+S D+T +W+A
Sbjct: 237 GTLLATGSYDGFARIWTK-DGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDA 295
Query: 449 ETGECIHTLYGHTSTVRCMHLHEKRV-VSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV 507
TGE H++ + S S D + V + + + GH V +
Sbjct: 296 HTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAI 355
Query: 508 QYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD-----------GIHV 554
++D G + S + D +K+W + + C+H LQ H +Y++++ + +
Sbjct: 356 KWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLML 415
Query: 555 VSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQ 612
S S D+++R+WDV+ G CIHTLT HQ + + L SG+ D V IW+ +TG
Sbjct: 416 ASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGA 475
Query: 613 CLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLK 652
+ + +G C + V S+ DG+V + DL+
Sbjct: 476 LVHSYRGTG--GIFEVCWNAAGDKVGASASDGSVCVLDLR 513
Score = 75.9 bits (185), Expect = 1e-13
Identities = 77/316 (24%), Positives = 121/316 (38%), Gaps = 71/316 (22%)
Query: 375 VLKGHDDHVITCL-QFCGNRIVSGSDDNTLKVW-------SAVTGKCLRTLVGHTGGV-- 424
VL+GH+ V C + + SGS D+T ++W S T LR + G
Sbjct: 164 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVP 223
Query: 425 ---------WSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR-- 473
W+S+ ++ +GS D ++W + G TL H + + ++K
Sbjct: 224 SNKDVTSLDWNSE--GTLLATGSYDGFARIWTKD-GNLASTLGQHKGPIFALKWNKKGNF 280
Query: 474 VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRV-VSGAYDFMVKVWDPETET 532
++S D T +WD TG+ H A V + S + D + V +
Sbjct: 281 ILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDR 340
Query: 533 CLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN 592
+ T QGHTN V ++++D TGN
Sbjct: 341 PIKTFQGHTNEVNAIKWD------------------PTGN-------------------- 362
Query: 593 ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQF-------NKNFVITSSD-DG 644
+L S + D T+KIW +K C+ LQ NK + N N ++ S+ D
Sbjct: 363 LLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDS 422
Query: 645 TVKLWDLKTGEFIRNL 660
TV+LWD+ G I L
Sbjct: 423 TVRLWDVDRGICIHTL 438
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 114 bits (284), Expect = 4e-25
Identities = 75/258 (29%), Positives = 122/258 (47%), Gaps = 15/258 (5%)
Query: 415 RTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL--H 470
R GH + S + N + + S D L +WN + + GH V + H
Sbjct: 12 RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPH 71
Query: 471 EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDP 528
+ S SRD T+R+W + H A VR V + DG+ + + + D +KVW
Sbjct: 72 GNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSM 131
Query: 529 ETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG 586
+ L++L HT+ V +F DG +VS S D +I++WD C++ + +
Sbjct: 132 YRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANF 191
Query: 587 MELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVITSSD 642
++ + + S +D TVK+WD++ + LQ Q H V C+ F+ N++IT+S
Sbjct: 192 VDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQ---VHSGGVNCISFHPSGNYLITASS 248
Query: 643 DGTVKLWDLKTGEFIRNL 660
DGT+K+ DL G I L
Sbjct: 249 DGTLKILDLLEGRLIYTL 266
Score = 105 bits (262), Expect = 1e-22
Identities = 71/241 (29%), Positives = 112/241 (46%), Gaps = 13/241 (5%)
Query: 378 GHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--I 433
GH D V+T +QF GN + S S D T+++W HT V S +
Sbjct: 58 GHKD-VVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQF 116
Query: 434 IISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETG 491
+ + S D+++KVW+ +++LY HT VRC + +VS S D T+++WD
Sbjct: 117 LATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNK 176
Query: 492 QCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF 549
QC++ V V ++ G + S D VKVWD L Q H+ V + F
Sbjct: 177 QCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISF 236
Query: 550 --DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMELKDNILVSGNADSTVKI 605
G ++++ S D ++++ D+ G I+TL GH T + SG AD+ V +
Sbjct: 237 HPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLL 296
Query: 606 W 606
W
Sbjct: 297 W 297
Score = 103 bits (257), Expect = 5e-22
Identities = 81/294 (27%), Positives = 134/294 (45%), Gaps = 26/294 (8%)
Query: 374 KVLKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM-- 429
+ KGH IT L G ++ + S D L +W+ VGH V S Q
Sbjct: 12 RYFKGHKA-AITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSP 70
Query: 430 RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWD 487
N++ S S DRT+++W + HT+ VR + + + + S D +++VW
Sbjct: 71 HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWS 130
Query: 488 IETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 545
+ + L+ L H VRC ++ DGR +VS + D +K+WD + C++
Sbjct: 131 MYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFAN 190
Query: 546 SLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG------MELKDNILVSG 597
+ F+ G + S D +++VWDV ++ L H + SG N L++
Sbjct: 191 FVDFNPSGTCIASAGSDQTVKVWDVR----VNKLLQHYQVHSGGVNCISFHPSGNYLITA 246
Query: 598 NADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSD--DGTVKLW 649
++D T+KI D+ G+ + TLQG H V + F+K + +S D V LW
Sbjct: 247 SSDGTLKILDLLEGRLIYTLQG---HTGPVFTVSFSKGGELFASGGADTQVLLW 297
Score = 44.3 bits (103), Expect = 4e-04
Identities = 26/90 (28%), Positives = 45/90 (50%), Gaps = 6/90 (6%)
Query: 369 ELKSPKVLKGHDDHV--ITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV 424
+++ K+L+ + H + C+ F GN +++ S D TLK+ + G+ + TL GHTG V
Sbjct: 214 DVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPV 273
Query: 425 W--SSQMRDNIIISGSTDRTLKVWNAETGE 452
+ S + SG D + +W E
Sbjct: 274 FTVSFSKGGELFASGGADTQVLLWRTNFDE 303
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 113 bits (283), Expect = 5e-25
Identities = 74/280 (26%), Positives = 129/280 (46%), Gaps = 21/280 (7%)
Query: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM--RDNIIISGSTDRTLKVWNA 448
G + +GS D ++W+ G TL H G +++ + + N I+S D+T +W+A
Sbjct: 249 GTLLATGSYDGFARIWTE-DGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDA 307
Query: 449 ETGECIHTLYGHTSTVRCMHLHEKRV-VSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV 507
TGE H++ + S S D + V + + + GH V +
Sbjct: 308 HTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAI 367
Query: 508 QYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD-----------GIHV 554
++D G + S + D +K+W + E C+H LQ H +Y++++ I +
Sbjct: 368 KWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIML 427
Query: 555 VSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQ 612
S S D+++R+WD+E G C HTLT HQ + + L SG+ D V IW+ ++G
Sbjct: 428 ASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGN 487
Query: 613 CLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLK 652
+ + +G C + V S+ DG+V + DL+
Sbjct: 488 LVHSYRGTG--GIFEVCWNARGDKVGASASDGSVCVLDLR 525
Score = 75.1 bits (183), Expect = 2e-13
Identities = 79/322 (24%), Positives = 125/322 (38%), Gaps = 77/322 (23%)
Query: 368 GELKSPK----VLKGHDDHVITCL-QFCGNRIVSGSDDNTLKVWSA-----------VTG 411
GE++ P VL+GH+ V C + + SGS D+T ++W+ V
Sbjct: 165 GEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLR 224
Query: 412 KCLRTLVGH--------TGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTST 463
C+R GH T W++ ++ +GS D ++W E G TL H
Sbjct: 225 HCIRE-GGHDVPSNKDVTSLDWNTN--GTLLATGSYDGFARIWT-EDGNLASTLGQHKGP 280
Query: 464 VRCMHLHEKR--VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRV-VSGAYD 520
+ + + K ++S D T +WD TG+ H A V + S + D
Sbjct: 281 IFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTD 340
Query: 521 FMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGH 580
+ V + + T QGHTN V ++++D
Sbjct: 341 MCIHVCRLGCDRPVKTFQGHTNEVNAIKWD------------------------------ 370
Query: 581 QSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAV-------TCLQFN 633
SGM +L S + D T+KIW +K C+ LQ NK + N
Sbjct: 371 ---PSGM-----LLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPN 422
Query: 634 KNFVITSSD-DGTVKLWDLKTG 654
N ++ S+ D TV+LWD++ G
Sbjct: 423 SNIMLASASFDSTVRLWDIERG 444
Score = 59.7 bits (143), Expect = 9e-09
Identities = 47/213 (22%), Positives = 97/213 (45%), Gaps = 35/213 (16%)
Query: 474 VVSGSRDATLRVWDIE---TGQCLHVLMGHVAAVRCVQYDGRRVVS-------------- 516
+ SGS D+T R+W++ G +++ H C++ G V S
Sbjct: 196 LASGSGDSTARIWNLNENSNGGSTQLVLRH-----CIREGGHDVPSNKDVTSLDWNTNGT 250
Query: 517 ----GAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVET 570
G+YD ++W E TL H +++L+++ G +++S +D + +WD T
Sbjct: 251 LLATGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHT 309
Query: 571 GNCIHTLTGHQSLTSGMELKDNI-LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTC 629
G H + ++ ++N S + D + + + + ++T QG H + V
Sbjct: 310 GEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQG---HTNEVNA 366
Query: 630 LQFNKNFVITSS--DDGTVKLWDLKTGEFIRNL 660
++++ + ++ +S DD T+K+W +K I +L
Sbjct: 367 IKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDL 399
Score = 47.4 bits (111), Expect = 5e-05
Identities = 34/139 (24%), Positives = 68/139 (48%), Gaps = 24/139 (17%)
Query: 537 LQGHTNRVYSLQFDGIH--VVSGSLDTSIRVWDVETGN-----------CI----HTLTG 579
L+GH + V+ ++ + + SGS D++ R+W++ + CI H +
Sbjct: 177 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 236
Query: 580 HQSLTS-GMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NF 636
++ +TS +L +G+ D +IW + G TL +H+ + L++N+ N+
Sbjct: 237 NKDVTSLDWNTNGTLLATGSYDGFARIWT-EDGNLASTL---GQHKGPIFALKWNRKGNY 292
Query: 637 VITSSDDGTVKLWDLKTGE 655
++++ D T +WD TGE
Sbjct: 293 ILSAGVDKTTIIWDAHTGE 311
Score = 33.1 bits (74), Expect = 0.91
Identities = 30/129 (23%), Positives = 50/129 (38%), Gaps = 22/129 (17%)
Query: 536 TLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMELKDNI 593
T+ G NR +S+ H +D + + + L GH+S ++
Sbjct: 143 TVNGEENRAHSVNN---HAKPMEIDGEVEI----PSSKATVLRGHESEVFICAWNPVSDL 195
Query: 594 LVSGNADSTVKIWDIKTG-----------QCLQTLQGPNKHQSAVTCLQFNKN--FVITS 640
L SG+ DST +IW++ C++ VT L +N N + T
Sbjct: 196 LASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATG 255
Query: 641 SDDGTVKLW 649
S DG ++W
Sbjct: 256 SYDGFARIW 264
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 113 bits (283), Expect = 5e-25
Identities = 74/280 (26%), Positives = 129/280 (46%), Gaps = 21/280 (7%)
Query: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM--RDNIIISGSTDRTLKVWNA 448
G + +GS D ++W+ G TL H G +++ + + N I+S D+T +W+A
Sbjct: 249 GTLLATGSYDGFARIWTE-DGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDA 307
Query: 449 ETGECIHTLYGHTSTVRCMHLHEKRV-VSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV 507
TGE H++ + S S D + V + + + GH V +
Sbjct: 308 HTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAI 367
Query: 508 QYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD-----------GIHV 554
++D G + S + D +K+W + E C+H LQ H +Y++++ I +
Sbjct: 368 KWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIML 427
Query: 555 VSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQ 612
S S D+++R+WD+E G C HTLT HQ + + L SG+ D V IW+ ++G
Sbjct: 428 ASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGN 487
Query: 613 CLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLK 652
+ + +G C + V S+ DG+V + DL+
Sbjct: 488 LVHSYRGTG--GIFEVCWNARGDKVGASASDGSVCVLDLR 525
Score = 75.1 bits (183), Expect = 2e-13
Identities = 79/322 (24%), Positives = 125/322 (38%), Gaps = 77/322 (23%)
Query: 368 GELKSPK----VLKGHDDHVITCL-QFCGNRIVSGSDDNTLKVWSA-----------VTG 411
GE++ P VL+GH+ V C + + SGS D+T ++W+ V
Sbjct: 165 GEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLR 224
Query: 412 KCLRTLVGH--------TGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTST 463
C+R GH T W++ ++ +GS D ++W E G TL H
Sbjct: 225 HCIRE-GGHDVPSNKDVTSLDWNTN--GTLLATGSYDGFARIWT-EDGNLASTLGQHKGP 280
Query: 464 VRCMHLHEKR--VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRV-VSGAYD 520
+ + + K ++S D T +WD TG+ H A V + S + D
Sbjct: 281 IFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTD 340
Query: 521 FMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGH 580
+ V + + T QGHTN V ++++D
Sbjct: 341 MCIHVCRLGCDRPVKTFQGHTNEVNAIKWD------------------------------ 370
Query: 581 QSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAV-------TCLQFN 633
SGM +L S + D T+KIW +K C+ LQ NK + N
Sbjct: 371 ---PSGM-----LLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPN 422
Query: 634 KNFVITSSD-DGTVKLWDLKTG 654
N ++ S+ D TV+LWD++ G
Sbjct: 423 SNIMLASASFDSTVRLWDIERG 444
Score = 59.7 bits (143), Expect = 9e-09
Identities = 47/213 (22%), Positives = 97/213 (45%), Gaps = 35/213 (16%)
Query: 474 VVSGSRDATLRVWDIE---TGQCLHVLMGHVAAVRCVQYDGRRVVS-------------- 516
+ SGS D+T R+W++ G +++ H C++ G V S
Sbjct: 196 LASGSGDSTARIWNLNENSNGGSTQLVLRH-----CIREGGHDVPSNKDVTSLDWNTNGT 250
Query: 517 ----GAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVET 570
G+YD ++W E TL H +++L+++ G +++S +D + +WD T
Sbjct: 251 LLATGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHT 309
Query: 571 GNCIHTLTGHQSLTSGMELKDNI-LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTC 629
G H + ++ ++N S + D + + + + ++T QG H + V
Sbjct: 310 GEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQG---HTNEVNA 366
Query: 630 LQFNKNFVITSS--DDGTVKLWDLKTGEFIRNL 660
++++ + ++ +S DD T+K+W +K I +L
Sbjct: 367 IKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDL 399
Score = 47.4 bits (111), Expect = 5e-05
Identities = 34/139 (24%), Positives = 68/139 (48%), Gaps = 24/139 (17%)
Query: 537 LQGHTNRVYSLQFDGIH--VVSGSLDTSIRVWDVETGN-----------CI----HTLTG 579
L+GH + V+ ++ + + SGS D++ R+W++ + CI H +
Sbjct: 177 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 236
Query: 580 HQSLTS-GMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NF 636
++ +TS +L +G+ D +IW + G TL +H+ + L++N+ N+
Sbjct: 237 NKDVTSLDWNTNGTLLATGSYDGFARIWT-EDGNLASTL---GQHKGPIFALKWNRKGNY 292
Query: 637 VITSSDDGTVKLWDLKTGE 655
++++ D T +WD TGE
Sbjct: 293 ILSAGVDKTTIIWDAHTGE 311
Score = 33.1 bits (74), Expect = 0.91
Identities = 30/129 (23%), Positives = 50/129 (38%), Gaps = 22/129 (17%)
Query: 536 TLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMELKDNI 593
T+ G NR +S+ H +D + + + L GH+S ++
Sbjct: 143 TVNGEENRAHSVNN---HAKPMEIDGEVEI----PSSKATVLRGHESEVFICAWNPVSDL 195
Query: 594 LVSGNADSTVKIWDIKTG-----------QCLQTLQGPNKHQSAVTCLQFNKN--FVITS 640
L SG+ DST +IW++ C++ VT L +N N + T
Sbjct: 196 LASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATG 255
Query: 641 SDDGTVKLW 649
S DG ++W
Sbjct: 256 SYDGFARIW 264
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,992,977
Number of Sequences: 37866
Number of extensions: 1487365
Number of successful extensions: 39088
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 734
Number of HSP's successfully gapped in prelim test: 595
Number of HSP's that attempted gapping in prelim test: 12908
Number of HSP's gapped (non-prelim): 10937
length of query: 707
length of database: 18,247,518
effective HSP length: 109
effective length of query: 598
effective length of database: 14,120,124
effective search space: 8443834152
effective search space used: 8443834152
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.