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Search of human proteins with 157738609
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157738609 HECT domain containing 3 [Homo sapiens]
(861 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157738609 HECT domain containing 3 [Homo sapiens] 1754 0.0
gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens] 196 6e-50
gi|126032348 hect domain and RLD 2 [Homo sapiens] 186 6e-47
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens] 112 2e-24
gi|157885806 chromosome 12 open reading frame 51 [Homo sapiens] 108 2e-23
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu... 105 1e-22
gi|187960100 ubiquitin protein ligase E3C [Homo sapiens] 96 2e-19
gi|41872646 cullin 7 [Homo sapiens] 94 7e-19
gi|24307991 p53-associated parkin-like cytoplasmic protein [Homo... 94 7e-19
gi|73747881 zinc finger, ZZ type with EF hand domain 1 [Homo sap... 92 3e-18
gi|190341084 HECT domain containing 2 isoform a [Homo sapiens] 88 4e-17
gi|35493952 ubiquitin protein ligase E3B [Homo sapiens] 87 7e-17
gi|35493959 ubiquitin protein ligase E3B [Homo sapiens] 87 7e-17
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi... 86 1e-16
gi|40806211 WW domain containing E3 ubiquitin protein ligase 2 i... 85 3e-16
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i... 85 3e-16
gi|114520609 neural precursor cell expressed, developmentally do... 85 3e-16
gi|114520607 neural precursor cell expressed, developmentally do... 85 3e-16
gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens] 84 4e-16
gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens] 84 4e-16
gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens] 84 4e-16
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa... 82 2e-15
gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [H... 82 3e-15
gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H... 82 3e-15
gi|15147337 ubiquitin protein ligase E3 component n-recognin 5 [... 81 4e-15
gi|239749462 PREDICTED: similar to ubiquitin protein ligase E3 c... 77 7e-14
gi|113420453 PREDICTED: similar to ubiquitin protein ligase E3 c... 77 7e-14
gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [... 77 7e-14
gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin prote... 77 7e-14
gi|10863903 thyroid hormone receptor interactor 12 [Homo sapiens] 75 3e-13
>gi|157738609 HECT domain containing 3 [Homo sapiens]
Length = 861
Score = 1754 bits (4542), Expect = 0.0
Identities = 861/861 (100%), Positives = 861/861 (100%)
Query: 1 MAGPGPGAVLESPRQLLGRVRFLAEAARSLRAGRPLPAALAFVPREVLYKLYKDPAGPSR 60
MAGPGPGAVLESPRQLLGRVRFLAEAARSLRAGRPLPAALAFVPREVLYKLYKDPAGPSR
Sbjct: 1 MAGPGPGAVLESPRQLLGRVRFLAEAARSLRAGRPLPAALAFVPREVLYKLYKDPAGPSR 60
Query: 61 VLLPVWEAEGLGLRVGAAGPAPGTGSGPLRAARDSIELRRGACVRTTGEELCNGHGLWVK 120
VLLPVWEAEGLGLRVGAAGPAPGTGSGPLRAARDSIELRRGACVRTTGEELCNGHGLWVK
Sbjct: 61 VLLPVWEAEGLGLRVGAAGPAPGTGSGPLRAARDSIELRRGACVRTTGEELCNGHGLWVK 120
Query: 121 LTKEQLAEHLGDCGLQEGWLLVCRPAEGGARLVPIDTPNHLQRQQQLFGVDYRPVLRWEQ 180
LTKEQLAEHLGDCGLQEGWLLVCRPAEGGARLVPIDTPNHLQRQQQLFGVDYRPVLRWEQ
Sbjct: 121 LTKEQLAEHLGDCGLQEGWLLVCRPAEGGARLVPIDTPNHLQRQQQLFGVDYRPVLRWEQ 180
Query: 181 VVDLTYSHRLGSRPQPAEAYAEAVQRLLYVPPTWTYECDEDLIHFLYDHLGKEDENLGSV 240
VVDLTYSHRLGSRPQPAEAYAEAVQRLLYVPPTWTYECDEDLIHFLYDHLGKEDENLGSV
Sbjct: 181 VVDLTYSHRLGSRPQPAEAYAEAVQRLLYVPPTWTYECDEDLIHFLYDHLGKEDENLGSV 240
Query: 241 KQYVESIDVSSYTEEFNVSCLTDSNADTYWESDGSQCQHWVRLTMKKGTIVKKLLLTVDT 300
KQYVESIDVSSYTEEFNVSCLTDSNADTYWESDGSQCQHWVRLTMKKGTIVKKLLLTVDT
Sbjct: 241 KQYVESIDVSSYTEEFNVSCLTDSNADTYWESDGSQCQHWVRLTMKKGTIVKKLLLTVDT 300
Query: 301 TDDNFMPKRVVVYGGEGDNLKKLSDVSIDETLIGDVCVLEDMTVHLPIIEIRIVECRDDG 360
TDDNFMPKRVVVYGGEGDNLKKLSDVSIDETLIGDVCVLEDMTVHLPIIEIRIVECRDDG
Sbjct: 301 TDDNFMPKRVVVYGGEGDNLKKLSDVSIDETLIGDVCVLEDMTVHLPIIEIRIVECRDDG 360
Query: 361 IDVRLRGVKIKSSRQRELGLNADLFQPTSLVRYPRLEGTDPEVLYRRAVLLQRFIKILDS 420
IDVRLRGVKIKSSRQRELGLNADLFQPTSLVRYPRLEGTDPEVLYRRAVLLQRFIKILDS
Sbjct: 361 IDVRLRGVKIKSSRQRELGLNADLFQPTSLVRYPRLEGTDPEVLYRRAVLLQRFIKILDS 420
Query: 421 VLHHLVPAWDHTLGTFSEIKQVKQFLLLSRQRPGLVAQCLRDSESSKPSFMPRLYINRRL 480
VLHHLVPAWDHTLGTFSEIKQVKQFLLLSRQRPGLVAQCLRDSESSKPSFMPRLYINRRL
Sbjct: 421 VLHHLVPAWDHTLGTFSEIKQVKQFLLLSRQRPGLVAQCLRDSESSKPSFMPRLYINRRL 480
Query: 481 AMEHRACPSRDPACKNAVFTQVYEGLKPSDKYEKPLDYRWPMRYDQWWECKFIAEGIIDQ 540
AMEHRACPSRDPACKNAVFTQVYEGLKPSDKYEKPLDYRWPMRYDQWWECKFIAEGIIDQ
Sbjct: 481 AMEHRACPSRDPACKNAVFTQVYEGLKPSDKYEKPLDYRWPMRYDQWWECKFIAEGIIDQ 540
Query: 541 GGGFRDSLADMSEELCPSSADTPVPLPFFVRTANQGNGTGEARDMYVPNPSCRDFAKYEW 600
GGGFRDSLADMSEELCPSSADTPVPLPFFVRTANQGNGTGEARDMYVPNPSCRDFAKYEW
Sbjct: 541 GGGFRDSLADMSEELCPSSADTPVPLPFFVRTANQGNGTGEARDMYVPNPSCRDFAKYEW 600
Query: 601 IGQLMGAALRGKEFLVLALPGFVWKQLSGEEVSWSKDFPAVDSVLVKLLEVMEGMDKETF 660
IGQLMGAALRGKEFLVLALPGFVWKQLSGEEVSWSKDFPAVDSVLVKLLEVMEGMDKETF
Sbjct: 601 IGQLMGAALRGKEFLVLALPGFVWKQLSGEEVSWSKDFPAVDSVLVKLLEVMEGMDKETF 660
Query: 661 EFKFGKELTFTTVLSDQQVVELIPGGAGIVVGYGDRSRFIQLVQKARLEESKEQVAAMQA 720
EFKFGKELTFTTVLSDQQVVELIPGGAGIVVGYGDRSRFIQLVQKARLEESKEQVAAMQA
Sbjct: 661 EFKFGKELTFTTVLSDQQVVELIPGGAGIVVGYGDRSRFIQLVQKARLEESKEQVAAMQA 720
Query: 721 GLLKVVPQAVLDLLTWQELEKKVCGDPEVTVDALRKLTRFEDFEPSDSRVQYFWEALNNF 780
GLLKVVPQAVLDLLTWQELEKKVCGDPEVTVDALRKLTRFEDFEPSDSRVQYFWEALNNF
Sbjct: 721 GLLKVVPQAVLDLLTWQELEKKVCGDPEVTVDALRKLTRFEDFEPSDSRVQYFWEALNNF 780
Query: 781 TNEDRSRFLRFVTGRSRLPARIYIYPDKLGYETTDALPESSTCSSTLFLPHYASAKVCEE 840
TNEDRSRFLRFVTGRSRLPARIYIYPDKLGYETTDALPESSTCSSTLFLPHYASAKVCEE
Sbjct: 781 TNEDRSRFLRFVTGRSRLPARIYIYPDKLGYETTDALPESSTCSSTLFLPHYASAKVCEE 840
Query: 841 KLRYAAYNCVAIDTDMSPWEE 861
KLRYAAYNCVAIDTDMSPWEE
Sbjct: 841 KLRYAAYNCVAIDTDMSPWEE 861
>gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]
Length = 4861
Score = 196 bits (499), Expect = 6e-50
Identities = 127/351 (36%), Positives = 191/351 (54%), Gaps = 23/351 (6%)
Query: 517 DYRWPMRYDQWWECKFIAEGIIDQGGGFRDSLADMSEELCPSSADTPVPLPFFVRTANQG 576
D R P R W+ K + EG D GG F D++ +M +EL D +P P N
Sbjct: 4504 DLRLPSRA---WKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSP------NAT 4554
Query: 577 NGTGEARDMYVPNPS-CRD--FAKYEWIGQLMGAALRGKEFLVLALPGFVWKQLSGEEVS 633
G RD ++ NPS C D +++++G LMG A+R K+ L L L VWKQL ++
Sbjct: 4555 AEVGYNRDRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLT 4614
Query: 634 WSKDFPAVDSVLVKLLEVM-----EGMDKETFEFKFGKELTFTTVLSDQQVVELIPGGAG 688
+D VD + V+ L + G+ +E+F + +F +D ++V +IPGG
Sbjct: 4615 L-EDLEEVDLLYVQTLNSILHIEDSGITEESFHEMIPLD-SFVGQSADGKMVPIIPGGNS 4672
Query: 689 IVVGYGDRSRFIQLVQKARLEESKEQVAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPE 748
I + + +R +++ + RL E QVAA++ G+ +VP +L LLT ++LE+ VCG PE
Sbjct: 4673 IPLTFSNRKEYVERAIEYRLHEMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPE 4732
Query: 749 VTVDALRKLTRFEDFEPSDSRVQYFWEALNNFTNEDRSRFLRFVTGRSRLPARIYIYPDK 808
++V+ L+K+ R+ + + VQ+FW L F+NE+R F+RFV+GRSRLPA +
Sbjct: 4733 ISVEVLKKVVRYREVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQR 4792
Query: 809 LGY----ETTDALPESSTCSSTLFLPHYASAKVCEEKLRYAAYNCVAIDTD 855
D+LP S TC L LP Y+S V E+LRYA NC +ID D
Sbjct: 4793 FQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSIDMD 4843
>gi|126032348 hect domain and RLD 2 [Homo sapiens]
Length = 4834
Score = 186 bits (473), Expect = 6e-47
Identities = 120/339 (35%), Positives = 184/339 (54%), Gaps = 21/339 (6%)
Query: 528 WECKFIAEGIIDQGGGFRDSLADMSEELCPSSADTPVPLPFFVRTANQGNGTGEARDMYV 587
W+ KF+ E + D GGG+ +S+A++ EEL P + T N + +G RD Y+
Sbjct: 4466 WKVKFVGESVDDCGGGYSESIAEICEELQNGLT------PLLIVTPNGRDESGANRDCYL 4519
Query: 588 PNPSCR---DFAKYEWIGQLMGAALRGKEFLVLALPGFVWKQLSGEEVSWSKDFPAVDSV 644
+P+ R + + ++G L+G A+R L L L VWKQL+G ++ + D VD
Sbjct: 4520 LSPAARAPVHSSMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIA-DLSEVDKD 4578
Query: 645 LVKLLEVMEGMDKETFEFKFGKELTFTTVLSDQQVVELIPGGAGIVVGYGDRSRFIQLVQ 704
+ L + + + EF+ L FT + Q ++L I + +R+ +++L
Sbjct: 4579 FIPGLMYIRDNEATSEEFE-AMSLPFTVPSASGQDIQLSSKHTHITLD--NRAEYVRLAI 4635
Query: 705 KARLEESKEQVAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEVTVDALRKLTRFEDFE 764
RL E EQVAA++ G+ +VVP +L L T ELE VCG P++ + L+ + ++ E
Sbjct: 4636 NYRLHEFDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKGIE 4695
Query: 765 PSDSRVQYFWEALNNFTNEDRSRFLRFVTGRSRLP-------ARIYIYPDKLGYETTD-A 816
PS S +Q+FWE + +F+N +RS FLRFV GR+RLP R ++ Y D
Sbjct: 4696 PSASLIQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRDFVIQVLDKYNPPDHF 4755
Query: 817 LPESSTCSSTLFLPHYASAKVCEEKLRYAAYNCVAIDTD 855
LPES TC L LP Y+ +V EEKL+YA + C +IDTD
Sbjct: 4756 LPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDTD 4794
Score = 76.6 bits (187), Expect = 9e-14
Identities = 49/133 (36%), Positives = 77/133 (57%), Gaps = 5/133 (3%)
Query: 237 LGSVKQYVESIDVSSYTEEFNVSCLTDSNADTYWESDGSQCQHWVRLTMKKGTIVKKLLL 296
L S + V+S++VSS + S L D + + W+S GSQ +HW+RL + +V +L +
Sbjct: 2779 LDSWSRMVKSLNVSSSVNQ--ASRLIDGS-EPCWQSSGSQGKHWIRLEIFPDVLVHRLKM 2835
Query: 297 TVDTTDDNFMPKRVVVYGGEG-DNLKKLSDVSIDETLIGDVCVLEDMTVHLPIIEIRIVE 355
VD D ++MP VVV GG +NL +L ++I+ + V +L D T + IEI I +
Sbjct: 2836 IVDPADSSYMPSLVVVSGGNSLNNLIELKTININPS-DTTVPLLNDCTEYHRYIEIAIKQ 2894
Query: 356 CRDDGIDVRLRGV 368
CR GID ++ G+
Sbjct: 2895 CRSSGIDCKIHGL 2907
>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
Length = 4374
Score = 112 bits (279), Expect = 2e-24
Identities = 78/285 (27%), Positives = 140/285 (49%), Gaps = 23/285 (8%)
Query: 583 RDMYVPNPSCR----DFAKYEWIGQLMGAALRGKEFLVLALPGFVWKQLSGEEVSWSKDF 638
R Y NPS + ++++G+++ A+ L +K + G+ V ++ D
Sbjct: 4088 RVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYT-DM 4146
Query: 639 PAVDSVLVKLLEVMEGMDKETFEFKFGKELTFTTVLSDQQVVE---LIPGGAGIVVGYGD 695
+ D + L + D T G +LTF+T + + V E L P GA I+V +
Sbjct: 4147 ESEDYHFYQGLVYLLENDVSTL----GYDLTFSTEVQEFGVCEVRDLKPNGANILVTEEN 4202
Query: 696 RSRFIQLVQKARLEES-KEQVAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEVTVDAL 754
+ ++ LV + R+ + ++Q+AA G +++P+ ++ + T QELE + G P + +D L
Sbjct: 4203 KKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDL 4262
Query: 755 RKLTRFEDFEPSDSRVQYFWEALNNFTNEDRSRFLRFVTGRSRLPAR----------IYI 804
+ T + ++ + ++Q+FW AL +F DR++FL+FVTG S++P + I
Sbjct: 4263 KSNTEYHKYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQK 4322
Query: 805 YPDKLGYETTDALPESSTCSSTLFLPHYASAKVCEEKLRYAAYNC 849
+ +TD LP + TC + L LP Y S + L A C
Sbjct: 4323 FQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQEC 4367
>gi|157885806 chromosome 12 open reading frame 51 [Homo sapiens]
Length = 3996
Score = 108 bits (271), Expect = 2e-23
Identities = 93/359 (25%), Positives = 159/359 (44%), Gaps = 50/359 (13%)
Query: 531 KFIAEGIIDQGGGFRDSLADMSEELCPSSADTPVPLPFFVRTANQGNGTGEARDMYVPNP 590
+F E + G FR L + +EL SS + P N+G Y+ P
Sbjct: 3638 RFTGEEVHGTSGSFRHFLWQVCKELQSSSLSLLLLCPSSAVNKNKGK--------YILTP 3689
Query: 591 SCRDFAKYE---WIGQLMGAALRGKEFLVLALPGFVWKQLSGEEVSWSKDFPAVDSVLVK 647
S + + + ++GQL+G A+R L L L WK L GE + +D D +
Sbjct: 3690 SPITYGEEQLLHFLGQLLGIAIRADVPLPLDLLPSFWKTLVGEPLDPEQDLQEADILTYN 3749
Query: 648 LLEVMEGMDKETFEFKFGKELT------------------FTTVLSDQQVVELIPGGAGI 689
++ E ++ ET E+ FT + + VEL G I
Sbjct: 3750 YVKKFESINDETELEALCAEIASQHLATESPDSPNKPCCRFTYLTMTGEEVELCSRGRHI 3809
Query: 690 VVGYGDRSRFIQLVQKARLEESK--EQVAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDP 747
+V + ++ + ++ RL E + E V A++AGL ++P +L +L+ E+E + CG P
Sbjct: 3810 LVAWENKDIYAAAIRSLRLRELQNVECVTAVRAGLGSIIPLQLLTMLSPLEMELRTCGLP 3869
Query: 748 EVTVDALRKLTRFE-DFEPSDSRVQYFWEALNNFTNEDRSRFLRFVTGRSRLP------- 799
+ ++ L+ T ++ +D +++FW AL FT E+ +F++F + R+P
Sbjct: 3870 YINLEFLKAHTMYQVGLMETDQHIEFFWGALEMFTQEELCKFIKFACNQERIPFTCPCKD 3929
Query: 800 -----ARIYIYPDKLG-YETTDALPES-----STCSSTLFLPHYASAKVCEEKLRYAAY 847
A + YP K+ + T P+S TC + LP Y+S ++ EKLR A +
Sbjct: 3930 GGPDTAHVPPYPMKIAPPDGTAGSPDSRYIRVETCMFMIKLPQYSSLEIMLEKLRCAIH 3988
>gi|116875852 HECT domain and ankyrin repeat containing, E3
ubiquitin protein ligase 1 [Homo sapiens]
Length = 909
Score = 105 bits (263), Expect = 1e-22
Identities = 76/265 (28%), Positives = 134/265 (50%), Gaps = 20/265 (7%)
Query: 598 YEWIGQLMGAALRGKEFLVLALPGFVWKQLSGEEVSWSKDFPAVDSVLVKLLEVMEGMDK 657
+ + GQ++G AL ++ + + +K + G V++ +D ++D K L+ + +D
Sbjct: 641 FRFAGQILGLALNHRQLVNIYFTRSFYKHILGIPVNY-QDVASIDPEYAKNLQWI--LDN 697
Query: 658 ETFEFKFGKELTF---TTVLSDQQVVELIPGGAGIVVGYGDRSRFIQLVQKARLEES-KE 713
+ + G ELTF T V + V L PGG I+V +++ ++QLV + R+ + +
Sbjct: 698 DISDL--GLELTFSVETDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQP 755
Query: 714 QVAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEVTVDALRKLTRFED-FEPSDSRVQY 772
Q+ A G +P +++ L ELE + G PE+ V K T + +E D +Q+
Sbjct: 756 QINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVSDWIKNTEYTSGYEREDPVIQW 815
Query: 773 FWEALNNFTNEDRSRFLRFVTGRSRLP----------ARIYIYPDKLGYETTDALPESST 822
FWE + + T E+R L+FVTG SR+P + + + T + LP SST
Sbjct: 816 FWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGGSGLQNFTIAAVPYTPNLLPTSST 875
Query: 823 CSSTLFLPHYASAKVCEEKLRYAAY 847
C + L LP Y S ++ +++L A +
Sbjct: 876 CINMLKLPEYPSKEILKDRLLVALH 900
>gi|187960100 ubiquitin protein ligase E3C [Homo sapiens]
Length = 1083
Score = 95.5 bits (236), Expect = 2e-19
Identities = 100/369 (27%), Positives = 162/369 (43%), Gaps = 42/369 (11%)
Query: 495 KNAVFTQVYEGLKPSDKYEKPLDYRWPMRYDQWWECKFIAEGIIDQGGGFRDSLADMSEE 554
+N ++ Y+ L P ++ + R + + E ID GG FR+ L E
Sbjct: 729 RNYIYEDAYDKLSPENEPDLKKRIRVHLL-----NAHGLDEAGIDGGGIFREFL----NE 779
Query: 555 LCPSSADTPVPLPFFVRTANQGNGTGEARDMYVPNPSCR-----DFAK-YEWIGQLMGAA 608
L S + P F +T N+G + PNP+ + FA+ Y ++G+++G A
Sbjct: 780 LLKSGFN---PNQGFFKTTNEG--------LLYPNPAAQMLVGDSFARHYYFLGRMLGKA 828
Query: 609 LRGKEFLVLALPGFVWKQLSGEEVSWS-KDFPAVDSVLVKLLEVMEGMDKETFEFKFGKE 667
L + L GF +L G ++D + K L ++ + + E
Sbjct: 829 LYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSYEDDVEELG---- 884
Query: 668 LTFTTV---LSDQQVVELIPGGAGIVVGYGDRSRFIQLVQKARLEES-KEQVAAMQAGLL 723
L FT V L + QVVEL GG I V +R +I LV RL ++ A + GL
Sbjct: 885 LNFTVVNNDLGEAQVVELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLA 944
Query: 724 KVVPQAVLDLLTWQELEKKVCG-DPEVTVDALRKLTRFEDFEPSDSRV-QYFWEALNNFT 781
VV L + QE++ + G ++++ L+ T + +D V + FW + FT
Sbjct: 945 NVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGGYSADHPVIKVFWRVVEGFT 1004
Query: 782 NEDRSRFLRFVTGRSRLPARIY--IYPD---KLGYETTDALPESSTCSSTLFLPHYASAK 836
+E++ + L+FVT SR P + +YP G + LP +STC + L LP +
Sbjct: 1005 DEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEFYDET 1064
Query: 837 VCEEKLRYA 845
+ KL YA
Sbjct: 1065 LLRSKLLYA 1073
>gi|41872646 cullin 7 [Homo sapiens]
Length = 1698
Score = 93.6 bits (231), Expect = 7e-19
Identities = 52/128 (40%), Positives = 81/128 (63%), Gaps = 5/128 (3%)
Query: 245 ESIDVSSYTEEFNVSCLTDSNADTYWESDGSQCQHWVRLTMKKGTIVKKLLLTVDTTDDN 304
E ++VSS S LTD N TYWES+GS H++ L M++G ++++L L V + D +
Sbjct: 842 EKVEVSS--NPHRASKLTDHNPKTYWESNGSAGSHYITLHMRRGILIRQLTLLVASEDSS 899
Query: 305 FMPKRVVVYGGEGDNL--KKLSDVSIDETLIGDVCVLEDMTVHLPIIEIRIVECRDDGID 362
+MP RVVV GG+ + +L+ V++ + V +LE++T PII+IRI C+ GID
Sbjct: 900 YMPARVVVCGGDSTSSLHTELNSVNVMPS-ASRVILLENLTRFWPIIQIRIKRCQQGGID 958
Query: 363 VRLRGVKI 370
R+RG++I
Sbjct: 959 TRIRGLEI 966
>gi|24307991 p53-associated parkin-like cytoplasmic protein [Homo
sapiens]
Length = 2517
Score = 93.6 bits (231), Expect = 7e-19
Identities = 52/128 (40%), Positives = 80/128 (62%), Gaps = 5/128 (3%)
Query: 245 ESIDVSSYTEEFNVSCLTDSNADTYWESDGSQCQHWVRLTMKKGTIVKKLLLTVDTTDDN 304
E ++VSS S LTD N TYWES+GS H++ L M +G +V++L L V + D +
Sbjct: 1171 EKVEVSS--NPHRASKLTDHNPKTYWESNGSTGSHYITLHMHRGVLVRQLTLLVASEDSS 1228
Query: 305 FMPKRVVVYGGEGDNL--KKLSDVSIDETLIGDVCVLEDMTVHLPIIEIRIVECRDDGID 362
+MP RVVV+GG+ + +L+ V++ + V +LE++ PII+IRI C+ GID
Sbjct: 1229 YMPARVVVFGGDSTSCIGTELNTVNVMPS-ASRVILLENLNRFWPIIQIRIKRCQQGGID 1287
Query: 363 VRLRGVKI 370
R+RGV++
Sbjct: 1288 TRVRGVEV 1295
>gi|73747881 zinc finger, ZZ type with EF hand domain 1 [Homo
sapiens]
Length = 2961
Score = 91.7 bits (226), Expect = 3e-18
Identities = 47/138 (34%), Positives = 78/138 (56%), Gaps = 3/138 (2%)
Query: 233 EDENLGSVKQYVESIDVSSYTEEFNVSCLTDSNADTYWESDGSQCQHWVRLTMKKGTIVK 292
E + L SV + I+ SS + + + +T+ +YW+SDGS C HW+RL MK +++
Sbjct: 242 EMDKLKSVAKCYAYIETSSNSAD--IDKMTNGETSSYWQSDGSACSHWIRLKMKPDVVLR 299
Query: 293 KLLLTVDTTDDNFMPKRV-VVYGGEGDNLKKLSDVSIDETLIGDVCVLEDMTVHLPIIEI 351
L + V TD ++MP++V V G +L+++ DV I + G V +LE+ V ++I
Sbjct: 300 HLSIAVAATDQSYMPQQVTVAVGRNASDLQEVRDVHIPSNVTGYVTLLENANVSQLYVQI 359
Query: 352 RIVECRDDGIDVRLRGVK 369
I C DG D R+ G++
Sbjct: 360 NIKRCLSDGCDTRIHGLR 377
>gi|190341084 HECT domain containing 2 isoform a [Homo sapiens]
Length = 776
Score = 87.8 bits (216), Expect = 4e-17
Identities = 71/268 (26%), Positives = 126/268 (47%), Gaps = 17/268 (6%)
Query: 592 CRDFAKYEWIGQLMGAALRGKEFLVLALPGFVWKQLSGEEVSWS-KDFPA------VDSV 644
C +++++ +G LMG A+ L + P +K+L + S ++ P VD +
Sbjct: 496 CDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKLLSPPIIPSDQNIPVGICNVTVDDL 555
Query: 645 LVKLLEVMEGMDKETFEFKFGKELTFTTVLSDQQVVELI------PGGAGIVVGYGDRSR 698
+ E+ G+ + +E ++T Q+ +I PGG I V +R
Sbjct: 556 CQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEEFGIIKSYNLKPGGDKISVTNQNRKE 615
Query: 699 FIQLVQKARLEES-KEQVAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEVTVDALRKL 757
++QL L +S +Q AA G V L LL +E+E VCG P++ + AL++
Sbjct: 616 YVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALMLLRPEEVEILVCGSPDLDMHALQRS 675
Query: 758 TRFEDFEPSDSRVQYFWEALNNFTNEDRSRFLRFVTGRSRLPA---RIYIYPDKLGYETT 814
T+++ + +D ++YFW+ + F + + + L F TG R+P + +T
Sbjct: 676 TQYDGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFTTGSDRVPVGGMADLNFKISKNETST 735
Query: 815 DALPESSTCSSTLFLPHYASAKVCEEKL 842
+ LP + TC + L LP Y S K ++KL
Sbjct: 736 NCLPVAHTCFNQLCLPPYKSKKDLKQKL 763
>gi|35493952 ubiquitin protein ligase E3B [Homo sapiens]
Length = 1068
Score = 87.0 bits (214), Expect = 7e-17
Identities = 93/355 (26%), Positives = 157/355 (44%), Gaps = 58/355 (16%)
Query: 533 IAEGIIDQGGGFRDSLADMSEELCPSSADTPVPLPFFVRTANQGNGTGEARDMYVPNPSC 592
+ E IDQ G F++ L ++ + + + L F T+ + P+P+
Sbjct: 720 VDEAGIDQDGVFKEFLEEIIKRVFDPA------LNLFKTTSGD--------ERLYPSPTS 765
Query: 593 RDFAKY----EWIGQLMGAALRGKEFLVLALPGFVWKQLSGEE----VSWSKDFPAVDSV 644
Y E++G+++G A+ + + F QL G S + P++DS
Sbjct: 766 YIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSE 825
Query: 645 LVKLLEVMEGMDKETFEFKFGKELTFTTVLSDQQVV-ELIPGGAGIVVGYGDRSRFIQLV 703
K L ++ D + + G L++ + Q V ELIPGG I V ++ +I L+
Sbjct: 826 FYKNLTSIKRYDGDITDL--GLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYIHLM 883
Query: 704 QKARLE-ESKEQVAAMQAGLLKVVPQAVLDLLTWQELEKKVCGD-PEVTVDALRKLT-RF 760
R+ + K Q AA+ +G ++ + + + EL++ + GD E+ ++ L+K T +
Sbjct: 884 AHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYY 943
Query: 761 EDFEPSDSRVQYFWEAL-NNFTNEDRSRFLRFVTGRSRLPARIYIY-------------- 805
F S + + W+ L ++FT ++R+ FL+FVT SR P + Y
Sbjct: 944 GGFHGSHRVIIWLWDILASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSD 1003
Query: 806 ----PDKLGY-----------ETTDALPESSTCSSTLFLPHYASAKVCEEKLRYA 845
D LG E LP SSTC + L LP+Y+ V EKLRYA
Sbjct: 1004 DQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYA 1058
>gi|35493959 ubiquitin protein ligase E3B [Homo sapiens]
Length = 1068
Score = 87.0 bits (214), Expect = 7e-17
Identities = 93/355 (26%), Positives = 157/355 (44%), Gaps = 58/355 (16%)
Query: 533 IAEGIIDQGGGFRDSLADMSEELCPSSADTPVPLPFFVRTANQGNGTGEARDMYVPNPSC 592
+ E IDQ G F++ L ++ + + + L F T+ + P+P+
Sbjct: 720 VDEAGIDQDGVFKEFLEEIIKRVFDPA------LNLFKTTSGD--------ERLYPSPTS 765
Query: 593 RDFAKY----EWIGQLMGAALRGKEFLVLALPGFVWKQLSGEE----VSWSKDFPAVDSV 644
Y E++G+++G A+ + + F QL G S + P++DS
Sbjct: 766 YIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSE 825
Query: 645 LVKLLEVMEGMDKETFEFKFGKELTFTTVLSDQQVV-ELIPGGAGIVVGYGDRSRFIQLV 703
K L ++ D + + G L++ + Q V ELIPGG I V ++ +I L+
Sbjct: 826 FYKNLTSIKRYDGDITDL--GLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYIHLM 883
Query: 704 QKARLE-ESKEQVAAMQAGLLKVVPQAVLDLLTWQELEKKVCGD-PEVTVDALRKLT-RF 760
R+ + K Q AA+ +G ++ + + + EL++ + GD E+ ++ L+K T +
Sbjct: 884 AHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYY 943
Query: 761 EDFEPSDSRVQYFWEAL-NNFTNEDRSRFLRFVTGRSRLPARIYIY-------------- 805
F S + + W+ L ++FT ++R+ FL+FVT SR P + Y
Sbjct: 944 GGFHGSHRVIIWLWDILASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSD 1003
Query: 806 ----PDKLGY-----------ETTDALPESSTCSSTLFLPHYASAKVCEEKLRYA 845
D LG E LP SSTC + L LP+Y+ V EKLRYA
Sbjct: 1004 DQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYA 1058
>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo
sapiens]
Length = 862
Score = 86.3 bits (212), Expect = 1e-16
Identities = 74/270 (27%), Positives = 126/270 (46%), Gaps = 27/270 (10%)
Query: 594 DFAKY-EWIGQLMGAALRGKEFLVLALPGFVWKQLSGEEVSWSKDFPAVDSVLVKLL--- 649
D KY +IG+ + AL +F+ +K++ + V KD ++D L
Sbjct: 592 DHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGL-KDLESIDPEFYNSLIWV 650
Query: 650 --EVMEGMDKETFEFKFGKELTFTTVLSDQQVVELIPGGAGIVVGYGDRSRFIQLVQKAR 707
+E D E + F KE +L + + +L P G I+V ++ +I++V + R
Sbjct: 651 KENNIEECDLEMY-FSVDKE-----ILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWR 704
Query: 708 LEES-KEQVAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEVTVDALRKLTRFEDFEPS 766
L +EQ A G +++PQ L +ELE +CG E+ ++ ++ + + +
Sbjct: 705 LSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYART 764
Query: 767 DSRVQYFWEALNNFTNEDRSRFLRFVTGRSRLPARIY-----------IYPDKLGYETTD 815
++ +FW+ + NE R R L+FVTG RLP + +K+G E +
Sbjct: 765 SKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKE--N 822
Query: 816 ALPESSTCSSTLFLPHYASAKVCEEKLRYA 845
LP S TC + L LP Y S + +EKL +A
Sbjct: 823 WLPRSHTCFNRLDLPPYKSYEQLKEKLLFA 852
>gi|40806211 WW domain containing E3 ubiquitin protein ligase 2
isoform 2 [Homo sapiens]
Length = 431
Score = 85.1 bits (209), Expect = 3e-16
Identities = 74/263 (28%), Positives = 117/263 (44%), Gaps = 22/263 (8%)
Query: 598 YEWIGQLMGAALRGKEFLVLALPGFVWKQLSGEEVSWSKDFPAVDSVLVKLLEVMEGMDK 657
+ +IG+ + AL +F+ +K++ + + KD ++D + ++ +
Sbjct: 166 FRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTL-KDLESIDPEFYNSIVWIKENNL 224
Query: 658 ETFEFKFGKELTFTT---VLSDQQVVELIPGGAGIVVGYGDRSRFIQLVQKARLEES-KE 713
E + G EL F +L EL GG I V ++ +I L+ R +E
Sbjct: 225 E----ECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEE 280
Query: 714 QVAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEVTVDALRKLTRFEDFEPSDSRVQYF 773
Q A G +V P L +ELE +CG E+ + +K T + + + ++Q+F
Sbjct: 281 QTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWF 340
Query: 774 WEALNNFTNEDRSRFLRFVTGRSRLPARIY-----------IYPDKLGYETTDALPESST 822
W+ + NE R R L+FVTG RLP + DK+G ET LP S T
Sbjct: 341 WQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETW--LPRSHT 398
Query: 823 CSSTLFLPHYASAKVCEEKLRYA 845
C + L LP Y S + EKL YA
Sbjct: 399 CFNRLDLPPYKSYEQLREKLLYA 421
>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
isoform 1 [Homo sapiens]
Length = 870
Score = 85.1 bits (209), Expect = 3e-16
Identities = 74/263 (28%), Positives = 117/263 (44%), Gaps = 22/263 (8%)
Query: 598 YEWIGQLMGAALRGKEFLVLALPGFVWKQLSGEEVSWSKDFPAVDSVLVKLLEVMEGMDK 657
+ +IG+ + AL +F+ +K++ + + KD ++D + ++ +
Sbjct: 605 FRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTL-KDLESIDPEFYNSIVWIKENNL 663
Query: 658 ETFEFKFGKELTFTT---VLSDQQVVELIPGGAGIVVGYGDRSRFIQLVQKARLEES-KE 713
E + G EL F +L EL GG I V ++ +I L+ R +E
Sbjct: 664 E----ECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEE 719
Query: 714 QVAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEVTVDALRKLTRFEDFEPSDSRVQYF 773
Q A G +V P L +ELE +CG E+ + +K T + + + ++Q+F
Sbjct: 720 QTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWF 779
Query: 774 WEALNNFTNEDRSRFLRFVTGRSRLPARIY-----------IYPDKLGYETTDALPESST 822
W+ + NE R R L+FVTG RLP + DK+G ET LP S T
Sbjct: 780 WQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETW--LPRSHT 837
Query: 823 CSSTLFLPHYASAKVCEEKLRYA 845
C + L LP Y S + EKL YA
Sbjct: 838 CFNRLDLPPYKSYEQLREKLLYA 860
>gi|114520609 neural precursor cell expressed, developmentally
down-regulated 4 isoform 1 [Homo sapiens]
Length = 900
Score = 84.7 bits (208), Expect = 3e-16
Identities = 60/184 (32%), Positives = 100/184 (54%), Gaps = 11/184 (5%)
Query: 681 ELIPGGAGIVVGYGDRSRFIQLVQKAR-LEESKEQVAAMQAGLLKVVPQAVLDLLTWQEL 739
EL GG+ IVV ++ +I LV + R + ++Q+AA + G +++PQ ++ + EL
Sbjct: 714 ELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENEL 773
Query: 740 EKKVCGDPEVTVDALRKLTRFED-FEPSDSRVQYFWEALNNFTNEDRSRFLRFVTGRSRL 798
E +CG +V V+ R+ T++++ + + +Q+FW+A+ +E R R L+FVTG SR+
Sbjct: 774 ELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRV 833
Query: 799 P----ARIY--IYPDKLGYE---TTDALPESSTCSSTLFLPHYASAKVCEEKLRYAAYNC 849
P A +Y P E T + LP + TC + L LP Y S + +KL+ A N
Sbjct: 834 PMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENT 893
Query: 850 VAID 853
D
Sbjct: 894 QGFD 897
>gi|114520607 neural precursor cell expressed, developmentally
down-regulated 4 isoform 2 [Homo sapiens]
Length = 1247
Score = 84.7 bits (208), Expect = 3e-16
Identities = 60/184 (32%), Positives = 100/184 (54%), Gaps = 11/184 (5%)
Query: 681 ELIPGGAGIVVGYGDRSRFIQLVQKAR-LEESKEQVAAMQAGLLKVVPQAVLDLLTWQEL 739
EL GG+ IVV ++ +I LV + R + ++Q+AA + G +++PQ ++ + EL
Sbjct: 1061 ELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENEL 1120
Query: 740 EKKVCGDPEVTVDALRKLTRFED-FEPSDSRVQYFWEALNNFTNEDRSRFLRFVTGRSRL 798
E +CG +V V+ R+ T++++ + + +Q+FW+A+ +E R R L+FVTG SR+
Sbjct: 1121 ELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRV 1180
Query: 799 P----ARIY--IYPDKLGYE---TTDALPESSTCSSTLFLPHYASAKVCEEKLRYAAYNC 849
P A +Y P E T + LP + TC + L LP Y S + +KL+ A N
Sbjct: 1181 PMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENT 1240
Query: 850 VAID 853
D
Sbjct: 1241 QGFD 1244
>gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]
Length = 872
Score = 84.3 bits (207), Expect = 4e-16
Identities = 74/273 (27%), Positives = 133/273 (48%), Gaps = 15/273 (5%)
Query: 581 EARDMYVPNPSCRDF-AKYEWIGQLMGAALRGKEFLVLALPGFVWKQLSGEEVSW---SK 636
E+ ++ NPS + ++ IG ++G A+ L + P V+++L G++ ++
Sbjct: 591 ESTKLFWFNPSSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGD 650
Query: 637 DFPAVDSVLVKLLEVMEGMDKETFEFKFGKELTFTTVLSDQQVVELIPGGAGIVVGYGDR 696
P + L LLE EG ++ F +++ T + + + +L G I + +R
Sbjct: 651 SHPVLYQSLKDLLEY-EGNVEDDMMITF--QISQTDLFGNPMMYDLKENGDKIPITNENR 707
Query: 697 SRFIQLVQKARLEESKE-QVAAMQAGLLKVVPQAVLD-LLTWQELEKKVCGDPEVTVDAL 754
F+ L L +S E Q A + G V ++ L L +E+E +CG + AL
Sbjct: 708 KEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQAL 767
Query: 755 RKLTRFEDFEPSDS-RVQYFWEALNNFTNEDRSRFLRFVTGRSRLP----ARIYIYPDKL 809
+ T ++ DS ++ FWE +++FT+E + FL+F TG R P ++ + K
Sbjct: 768 EETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKN 827
Query: 810 GYETTDALPESSTCSSTLFLPHYASAKVCEEKL 842
G + T+ LP S TC + L LP Y+S + +E+L
Sbjct: 828 GPD-TERLPTSHTCFNVLLLPEYSSKEKLKERL 859
>gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]
Length = 852
Score = 84.3 bits (207), Expect = 4e-16
Identities = 74/273 (27%), Positives = 133/273 (48%), Gaps = 15/273 (5%)
Query: 581 EARDMYVPNPSCRDF-AKYEWIGQLMGAALRGKEFLVLALPGFVWKQLSGEEVSW---SK 636
E+ ++ NPS + ++ IG ++G A+ L + P V+++L G++ ++
Sbjct: 571 ESTKLFWFNPSSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGD 630
Query: 637 DFPAVDSVLVKLLEVMEGMDKETFEFKFGKELTFTTVLSDQQVVELIPGGAGIVVGYGDR 696
P + L LLE EG ++ F +++ T + + + +L G I + +R
Sbjct: 631 SHPVLYQSLKDLLEY-EGNVEDDMMITF--QISQTDLFGNPMMYDLKENGDKIPITNENR 687
Query: 697 SRFIQLVQKARLEESKE-QVAAMQAGLLKVVPQAVLD-LLTWQELEKKVCGDPEVTVDAL 754
F+ L L +S E Q A + G V ++ L L +E+E +CG + AL
Sbjct: 688 KEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQAL 747
Query: 755 RKLTRFEDFEPSDS-RVQYFWEALNNFTNEDRSRFLRFVTGRSRLP----ARIYIYPDKL 809
+ T ++ DS ++ FWE +++FT+E + FL+F TG R P ++ + K
Sbjct: 748 EETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKN 807
Query: 810 GYETTDALPESSTCSSTLFLPHYASAKVCEEKL 842
G + T+ LP S TC + L LP Y+S + +E+L
Sbjct: 808 GPD-TERLPTSHTCFNVLLLPEYSSKEKLKERL 839
>gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]
Length = 875
Score = 84.3 bits (207), Expect = 4e-16
Identities = 74/273 (27%), Positives = 133/273 (48%), Gaps = 15/273 (5%)
Query: 581 EARDMYVPNPSCRDF-AKYEWIGQLMGAALRGKEFLVLALPGFVWKQLSGEEVSW---SK 636
E+ ++ NPS + ++ IG ++G A+ L + P V+++L G++ ++
Sbjct: 594 ESTKLFWFNPSSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGD 653
Query: 637 DFPAVDSVLVKLLEVMEGMDKETFEFKFGKELTFTTVLSDQQVVELIPGGAGIVVGYGDR 696
P + L LLE EG ++ F +++ T + + + +L G I + +R
Sbjct: 654 SHPVLYQSLKDLLEY-EGNVEDDMMITF--QISQTDLFGNPMMYDLKENGDKIPITNENR 710
Query: 697 SRFIQLVQKARLEESKE-QVAAMQAGLLKVVPQAVLD-LLTWQELEKKVCGDPEVTVDAL 754
F+ L L +S E Q A + G V ++ L L +E+E +CG + AL
Sbjct: 711 KEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQAL 770
Query: 755 RKLTRFEDFEPSDS-RVQYFWEALNNFTNEDRSRFLRFVTGRSRLP----ARIYIYPDKL 809
+ T ++ DS ++ FWE +++FT+E + FL+F TG R P ++ + K
Sbjct: 771 EETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKN 830
Query: 810 GYETTDALPESSTCSSTLFLPHYASAKVCEEKL 842
G + T+ LP S TC + L LP Y+S + +E+L
Sbjct: 831 GPD-TERLPTSHTCFNVLLLPEYSSKEKLKERL 862
>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
sapiens]
Length = 748
Score = 82.4 bits (202), Expect = 2e-15
Identities = 69/257 (26%), Positives = 122/257 (47%), Gaps = 16/257 (6%)
Query: 598 YEWIGQLMGAALRGKEFLVLALPGFVWKQLSGEEVSWSKDFPAVDSVLVK-LLEVMEGMD 656
+ ++G++MG A+ ++ +KQL G+ ++ D VD L L+ ++E
Sbjct: 483 FHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLD-DMELVDPDLHNSLVWILENDI 541
Query: 657 KETFEFKFGKELTFTTVLSDQQVVELIPGGAGIVVGYGDRSRFIQLVQKAR-LEESKEQV 715
+ F E + EL P G I V ++ +++L R L + Q
Sbjct: 542 TGVLDHTFCVEHNAYGEIIQH---ELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQF 598
Query: 716 AAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEVTVDALRKLTRFEDFEPSDSRVQYFWE 775
A+Q G +V+PQ +L +ELE +CG ++ V+ + TR + P + V++FW+
Sbjct: 599 LALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKVNTRLKHCTPDSNIVKWFWK 658
Query: 776 ALNNFTNEDRSRFLRFVTGRSRLPARIY----------IYPDKLGYETTDALPESSTCSS 825
A+ F E R+R L+FVTG SR+P + + ++ T+ LP++ TC +
Sbjct: 659 AVEFFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFN 718
Query: 826 TLFLPHYASAKVCEEKL 842
+ +P Y S + EKL
Sbjct: 719 RIDIPPYESYEKLYEKL 735
>gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [Homo
sapiens]
Length = 757
Score = 81.6 bits (200), Expect = 3e-15
Identities = 69/261 (26%), Positives = 124/261 (47%), Gaps = 21/261 (8%)
Query: 598 YEWIGQLMGAALRGKEFLVLALPGFVWKQLSGEEVSWSKDFPAVDSVLVK-LLEVMEGMD 656
+ ++G++MG A+ ++ +KQL G+ + S D +VD L K L+ ++E
Sbjct: 489 FHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLS-DLESVDPELHKSLVWILENDI 547
Query: 657 KETFEFKFGKELT-FTTVLSDQQVVELIPGGAGIVVGYGDRSRFIQLVQKARLEESKE-Q 714
+ F E F +L EL P G + V ++ +++L R E Q
Sbjct: 548 TPVLDHTFCVEHNAFGRILQH----ELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQ 603
Query: 715 VAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEVTVDALRKLTRFEDFEPSDSRVQYFW 774
A+Q G +++PQ +L +ELE + G ++ ++ + TR + + V++FW
Sbjct: 604 FLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFW 663
Query: 775 EALNNFTNEDRSRFLRFVTGRSRLPARIY-------------IYPDKLGYETTDALPESS 821
+A+ F E R+R L+FVTG +R+P + + ++ L TD LP++
Sbjct: 664 QAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAH 723
Query: 822 TCSSTLFLPHYASAKVCEEKL 842
TC + + +P Y S + EKL
Sbjct: 724 TCFNRIDIPPYESYEKLYEKL 744
>gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo
sapiens]
Length = 731
Score = 81.6 bits (200), Expect = 3e-15
Identities = 69/261 (26%), Positives = 124/261 (47%), Gaps = 21/261 (8%)
Query: 598 YEWIGQLMGAALRGKEFLVLALPGFVWKQLSGEEVSWSKDFPAVDSVLVK-LLEVMEGMD 656
+ ++G++MG A+ ++ +KQL G+ + S D +VD L K L+ ++E
Sbjct: 463 FHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLS-DLESVDPELHKSLVWILENDI 521
Query: 657 KETFEFKFGKELT-FTTVLSDQQVVELIPGGAGIVVGYGDRSRFIQLVQKARLEESKE-Q 714
+ F E F +L EL P G + V ++ +++L R E Q
Sbjct: 522 TPVLDHTFCVEHNAFGRILQH----ELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQ 577
Query: 715 VAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEVTVDALRKLTRFEDFEPSDSRVQYFW 774
A+Q G +++PQ +L +ELE + G ++ ++ + TR + + V++FW
Sbjct: 578 FLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFW 637
Query: 775 EALNNFTNEDRSRFLRFVTGRSRLPARIY-------------IYPDKLGYETTDALPESS 821
+A+ F E R+R L+FVTG +R+P + + ++ L TD LP++
Sbjct: 638 QAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAH 697
Query: 822 TCSSTLFLPHYASAKVCEEKL 842
TC + + +P Y S + EKL
Sbjct: 698 TCFNRIDIPPYESYEKLYEKL 718
>gi|15147337 ubiquitin protein ligase E3 component n-recognin 5 [Homo
sapiens]
Length = 2799
Score = 81.3 bits (199), Expect = 4e-15
Identities = 80/286 (27%), Positives = 126/286 (44%), Gaps = 29/286 (10%)
Query: 583 RDMYVPNPSCRDFAK---YEWIGQLMGAALRGKEFLVLALPGFVWKQLSGEEVSWSKDFP 639
R Y P P A+ + IG+++G L E + L V K L G +V+W DF
Sbjct: 2511 RGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWH-DFA 2569
Query: 640 AVDSVLVKLLE--VMEGMDKETFEFKFGKELTFTTVLSDQQ---VVELIPGGAGIVVGYG 694
D V+ + L ++ + +L F L ++ VELIP G I V
Sbjct: 2570 FFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQ 2629
Query: 695 DRSRFIQLVQKARLEESKEQ-VAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEVTVDA 753
+ +++ + R+ EQ + AM+ GLL V+P+ L+ LT ++ V G EV V
Sbjct: 2630 NVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQM 2689
Query: 754 LRKLTRFED--FEPSDSRVQY---FWEALNNFTNEDRSRFLRFVTGRSRLPA-------- 800
L T F D E ++ +Q+ FW + + +R + F T LPA
Sbjct: 2690 LISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPM 2749
Query: 801 -RIYIYPDKLGYETTDALPESSTCSSTLFLPHYASAKVCEEKLRYA 845
I I P LP ++TC S L++P Y+S ++ ++KL A
Sbjct: 2750 PSITIRP-----PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLA 2790
>gi|239749462 PREDICTED: similar to ubiquitin protein ligase E3
component n-recognin 5 isoform 2 [Homo sapiens]
Length = 2277
Score = 77.0 bits (188), Expect = 7e-14
Identities = 79/286 (27%), Positives = 125/286 (43%), Gaps = 29/286 (10%)
Query: 583 RDMYVPNPSCRDFAK---YEWIGQLMGAALRGKEFLVLALPGFVWKQLSGEEVSWSKDFP 639
R Y P P A+ + IG+++G L E + L V K L G +V+W DF
Sbjct: 1989 RGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWH-DFA 2047
Query: 640 AVDSVLVKLLE--VMEGMDKETFEFKFGKELTFTTVLSDQQ---VVELIPGGAGIVVGYG 694
D V+ + L ++ + +L F L ++ VELIP G V
Sbjct: 2048 FFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVKRPVTPQ 2107
Query: 695 DRSRFIQLVQKARLEESKEQ-VAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEVTVDA 753
+ +++ + R+ EQ + AM+ GLL V+P+ L+ LT ++ V G EV V
Sbjct: 2108 NVYEYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQM 2167
Query: 754 LRKLTRFED--FEPSDSRVQY---FWEALNNFTNEDRSRFLRFVTGRSRLPA-------- 800
L T F D E ++ +Q+ FW + + +R + F T LPA
Sbjct: 2168 LISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPM 2227
Query: 801 -RIYIYPDKLGYETTDALPESSTCSSTLFLPHYASAKVCEEKLRYA 845
I I P LP ++TC S L++P Y+S ++ ++KL A
Sbjct: 2228 PSITIRP-----PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLA 2268
>gi|113420453 PREDICTED: similar to ubiquitin protein ligase E3
component n-recognin 5 isoform 1 [Homo sapiens]
Length = 2796
Score = 77.0 bits (188), Expect = 7e-14
Identities = 79/286 (27%), Positives = 125/286 (43%), Gaps = 29/286 (10%)
Query: 583 RDMYVPNPSCRDFAK---YEWIGQLMGAALRGKEFLVLALPGFVWKQLSGEEVSWSKDFP 639
R Y P P A+ + IG+++G L E + L V K L G +V+W DF
Sbjct: 2508 RGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWH-DFA 2566
Query: 640 AVDSVLVKLLE--VMEGMDKETFEFKFGKELTFTTVLSDQQ---VVELIPGGAGIVVGYG 694
D V+ + L ++ + +L F L ++ VELIP G V
Sbjct: 2567 FFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVKRPVTPQ 2626
Query: 695 DRSRFIQLVQKARLEESKEQ-VAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEVTVDA 753
+ +++ + R+ EQ + AM+ GLL V+P+ L+ LT ++ V G EV V
Sbjct: 2627 NVYEYVRKDAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQM 2686
Query: 754 LRKLTRFED--FEPSDSRVQY---FWEALNNFTNEDRSRFLRFVTGRSRLPA-------- 800
L T F D E ++ +Q+ FW + + +R + F T LPA
Sbjct: 2687 LISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPM 2746
Query: 801 -RIYIYPDKLGYETTDALPESSTCSSTLFLPHYASAKVCEEKLRYA 845
I I P LP ++TC S L++P Y+S ++ ++KL A
Sbjct: 2747 PSITIRP-----PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLA 2787
>gi|13654239 WW domain containing E3 ubiquitin protein ligase 1
[Homo sapiens]
Length = 922
Score = 77.0 bits (188), Expect = 7e-14
Identities = 70/261 (26%), Positives = 123/261 (47%), Gaps = 22/261 (8%)
Query: 600 WIGQLMGAALRGKEFLVLALPGFVWKQLSGEEVSWSKDFPAVDSVLVKLLEVMEGMDKET 659
+IG+ + AL +F+ +K++ ++++ KD ++D+ L + + E
Sbjct: 659 FIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLT-IKDLESIDTEFYNSLIWIRDNNIE- 716
Query: 660 FEFKFGKELTFTT---VLSDQQVVELIPGGAGIVVGYGDRSRFIQLVQKARLEES-KEQV 715
+ G E+ F+ +L +L GG+ I+V ++ +I L+ + R +EQ
Sbjct: 717 ---ECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQT 773
Query: 716 AAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEVTVDALRKLTRFEDFEPSDSRVQYFWE 775
A G +VVP L +ELE +CG EV + ++ T + + + ++ +FW+
Sbjct: 774 KAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQIIWFWQ 833
Query: 776 ALNNFTNEDRSRFLRFVTGRSRLPARIY-----------IYPDKLGYETTDALPESSTCS 824
+ NE R R L+FVTG RLP + +K+G +T LP S TC
Sbjct: 834 FVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTW--LPRSHTCF 891
Query: 825 STLFLPHYASAKVCEEKLRYA 845
+ L LP Y S + +EKL +A
Sbjct: 892 NRLDLPPYKSYEQLKEKLLFA 912
>gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin protein
ligase 2 [Homo sapiens]
Length = 1572
Score = 77.0 bits (188), Expect = 7e-14
Identities = 59/192 (30%), Positives = 91/192 (47%), Gaps = 18/192 (9%)
Query: 667 ELTFTT---VLSDQQVVELIPGGAGIVVGYGDRSRFIQLVQKARLEESK-EQVAAMQAGL 722
+LTFT V EL PGGA I V ++ +I+ + K R+E +Q ++ G
Sbjct: 1370 DLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGF 1429
Query: 723 LKVVPQAVLDLLTWQELEKKVCGDPEVTVDALRKLTRFED-FEPSDSRVQYFWEALNNFT 781
+VV ++ + +ELE + G E+ + R T + + + +++FW A+ F
Sbjct: 1430 YEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFN 1489
Query: 782 NEDRSRFLRFVTGRSRLPARIY-----------IYPDKLGYETTDALPESSTCSSTLFLP 830
NE R R L+FVTG S +P + +K G T ALP + TC + L LP
Sbjct: 1490 NEQRLRLLQFVTGTSSIPYEGFASLRGSNGPRRFCVEKWGKIT--ALPRAHTCFNRLDLP 1547
Query: 831 HYASAKVCEEKL 842
Y S + EKL
Sbjct: 1548 PYPSFSMLYEKL 1559
>gi|10863903 thyroid hormone receptor interactor 12 [Homo sapiens]
Length = 1992
Score = 75.1 bits (183), Expect = 3e-13
Identities = 83/288 (28%), Positives = 127/288 (44%), Gaps = 39/288 (13%)
Query: 597 KYEWIGQLMGAALRGKEF--LVLALPGFVWKQLSGEEVSWSKDFPAVDSVLV-------- 646
K+ ++G+LM A+ L L LP + W L E S D +D V+
Sbjct: 1696 KFRFLGKLMAKAIMDFRLVDLPLGLPFYKW-MLRQETSLTSHDLFDIDPVVARSVYHLED 1754
Query: 647 -----KLLEVMEGMDKETFEFKFG---------KELTFTTVLSDQQVVELIPGGAGIVVG 692
K LE + KE+ ++ ++L L +EL GG I V
Sbjct: 1755 IVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLGLDFTLPGFPNIELKKGGKDIPVT 1814
Query: 693 YGDRSRFIQLVQKARLEES-KEQVAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEVTV 751
+ +++LV L E Q + + G V P + L +EL++ +CG T
Sbjct: 1815 IHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYFYPEELDQLLCGSKADTW 1874
Query: 752 DA--LRKLTRFEDFEPSDSR-VQYFWEALNNFTNEDRSRFLRFVTGRSRLPARIY--IYP 806
DA L + R + DSR V++ +E L++F NE + FL+FVTG RLP + + P
Sbjct: 1875 DAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSLNP 1934
Query: 807 D----KLGYETT----DALPESSTCSSTLFLPHYASAKVCEEKLRYAA 846
+ +E+T D LP TC + L LP Y+S ++ EKL AA
Sbjct: 1935 PLTIVRKTFESTENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLIAA 1982
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.138 0.423
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,709,972
Number of Sequences: 37866
Number of extensions: 1731762
Number of successful extensions: 4165
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 51
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 4001
Number of HSP's gapped (non-prelim): 87
length of query: 861
length of database: 18,247,518
effective HSP length: 111
effective length of query: 750
effective length of database: 14,044,392
effective search space: 10533294000
effective search space used: 10533294000
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.