Search of human proteins with 157384977

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|157384977 glutamate receptor, ionotropic, delta 2 [Homo
sapiens]
         (1007 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|157384977 glutamate receptor, ionotropic, delta 2 [Homo sapiens]  2041   0.0  
gi|55770852 glutamate receptor, ionotropic, delta 1 precursor [H...  1169   0.0  
gi|28416444 glutamate receptor, ionotropic, kainate 1 isoform 2 ...   366   e-101
gi|4504117 glutamate receptor, ionotropic, kainate 1 isoform 1 p...   362   e-100
gi|11386137 glutamate receptor, ionotropic, kainate 2 isoform 1 ...   357   3e-98
gi|28559003 glutamate receptor, ionotropic, kainate 2 isoform 2 ...   357   4e-98
gi|167001419 glutamate receptor, ionotropic, AMPA 1 isoform 1 [H...   356   5e-98
gi|167001484 glutamate receptor, ionotropic, AMPA 1 isoform 2 [H...   354   2e-97
gi|134304848 glutamate receptor, ionotropic, AMPA 2 isoform 2 pr...   348   1e-95
gi|74275354 glutamate receptor, ionotropic, AMPA 2 isoform 1 pre...   347   4e-95
gi|28605145 glutamate receptor, ionotropic, kainate 3 precursor ...   345   9e-95
gi|163659858 glutamate receptor, ionotrophic, AMPA 3 isoform 2 p...   341   2e-93
gi|163659856 glutamate receptor, ionotrophic, AMPA 3 isoform 1 p...   340   5e-93
gi|134304851 glutamate receptor, ionotropic, AMPA 2 isoform 3 [H...   339   9e-93
gi|164419736 glutamate receptor, ionotrophic, AMPA 4 isoform 2 p...   337   4e-92
gi|164419734 glutamate receptor, ionotrophic, AMPA 4 isoform 1 p...   333   4e-91
gi|29029595 glutamate receptor KA1 precursor [Homo sapiens]           305   1e-82
gi|29029597 glutamate receptor KA2 precursor [Homo sapiens]           301   2e-81
gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens]    198   2e-50
gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens]    198   2e-50
gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens]    198   2e-50
gi|197313638 N-methyl-D-aspartate receptor subunit 2A isoform 2 ...   173   6e-43
gi|197313636 N-methyl-D-aspartate receptor subunit 2A isoform 1 ...   173   6e-43
gi|4504125 N-methyl-D-aspartate receptor subunit 2A isoform 1 pr...   173   6e-43
gi|153946391 N-methyl-D-aspartate receptor subunit 2D precursor ...   167   4e-41
gi|167003331 N-methyl-D-aspartate receptor subunit 2B precursor ...   166   8e-41
gi|55770854 N-methyl-D-aspartate receptor subunit 2C precursor [...   159   2e-38
gi|223278356 glutamate receptor, ionotropic, N-methyl-D-aspartat...   149   1e-35
gi|62988346 glutamate receptor, ionotropic, N-methyl-D-aspartate...   147   6e-35
gi|116284390 glutamate receptor, ionotrophic, AMPA 4 isoform 3 p...    85   4e-16

>gi|157384977 glutamate receptor, ionotropic, delta 2 [Homo sapiens]
          Length = 1007

 Score = 2041 bits (5288), Expect = 0.0
 Identities = 1007/1007 (100%), Positives = 1007/1007 (100%)

Query: 1    MEVFPFLLVLSVWWSRTWDSANADSIIHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQT 60
            MEVFPFLLVLSVWWSRTWDSANADSIIHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQT
Sbjct: 1    MEVFPFLLVLSVWWSRTWDSANADSIIHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQT 60

Query: 61   EKITFSVTFVDGNNPFQAVQEACELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQ 120
            EKITFSVTFVDGNNPFQAVQEACELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQ
Sbjct: 61   EKITFSVTFVDGNNPFQAVQEACELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQ 120

Query: 121  RSTAGTPRSGCGLTRSNRNDDYTLSVRPPVYLHDVILRVVTEYAWQKFIIFYDSEYDIRG 180
            RSTAGTPRSGCGLTRSNRNDDYTLSVRPPVYLHDVILRVVTEYAWQKFIIFYDSEYDIRG
Sbjct: 121  RSTAGTPRSGCGLTRSNRNDDYTLSVRPPVYLHDVILRVVTEYAWQKFIIFYDSEYDIRG 180

Query: 181  IQEFLDKVSQQGMDVALQKVENNINKMITTLFDTMRIEELNRYRDTLRRAILVMNPATAK 240
            IQEFLDKVSQQGMDVALQKVENNINKMITTLFDTMRIEELNRYRDTLRRAILVMNPATAK
Sbjct: 181  IQEFLDKVSQQGMDVALQKVENNINKMITTLFDTMRIEELNRYRDTLRRAILVMNPATAK 240

Query: 241  SFITEVVETNLVAFDCHWIIINEEINDVDVQELVRRSIGRLTIIRQTFPVPQNISQRCFR 300
            SFITEVVETNLVAFDCHWIIINEEINDVDVQELVRRSIGRLTIIRQTFPVPQNISQRCFR
Sbjct: 241  SFITEVVETNLVAFDCHWIIINEEINDVDVQELVRRSIGRLTIIRQTFPVPQNISQRCFR 300

Query: 301  GNHRISSTLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIRKNS 360
            GNHRISSTLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIRKNS
Sbjct: 301  GNHRISSTLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIRKNS 360

Query: 361  KPWQGGRSMLETIKKGGVSGLTGELEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWN 420
            KPWQGGRSMLETIKKGGVSGLTGELEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWN
Sbjct: 361  KPWQGGRSMLETIKKGGVSGLTGELEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWN 420

Query: 421  PVTGLNGSLTDKKLENNMRGVVLRVVTVLEEPFVMVSENVLGKPKKYQGFSIDVLDALSN 480
            PVTGLNGSLTDKKLENNMRGVVLRVVTVLEEPFVMVSENVLGKPKKYQGFSIDVLDALSN
Sbjct: 421  PVTGLNGSLTDKKLENNMRGVVLRVVTVLEEPFVMVSENVLGKPKKYQGFSIDVLDALSN 480

Query: 481  YLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRY 540
            YLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRY
Sbjct: 481  YLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRY 540

Query: 541  MDYSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNPPRLQMGSM 600
            MDYSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNPPRLQMGSM
Sbjct: 541  MDYSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNPPRLQMGSM 600

Query: 601  TSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITR 660
            TSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITR
Sbjct: 601  TSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITR 660

Query: 661  IESSIQSLQDLSKQTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWRMINRSNGSEN 720
            IESSIQSLQDLSKQTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWRMINRSNGSEN
Sbjct: 661  IESSIQSLQDLSKQTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWRMINRSNGSEN 720

Query: 721  NVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTIGNTVADRGYGIALQHGSPY 780
            NVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTIGNTVADRGYGIALQHGSPY
Sbjct: 721  NVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTIGNTVADRGYGIALQHGSPY 780

Query: 781  RDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIKSFAGVFCILAA 840
            RDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIKSFAGVFCILAA
Sbjct: 781  RDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIKSFAGVFCILAA 840

Query: 841  GIVLSCFIAMLETWWNKRKGSRVPSKEDDKEIDLEHLHRRVNSLCTDDDSPHKQFSTSSI 900
            GIVLSCFIAMLETWWNKRKGSRVPSKEDDKEIDLEHLHRRVNSLCTDDDSPHKQFSTSSI
Sbjct: 841  GIVLSCFIAMLETWWNKRKGSRVPSKEDDKEIDLEHLHRRVNSLCTDDDSPHKQFSTSSI 900

Query: 901  DLTPLDIDTLPTRQALEQISDFRNTHITTTTFIPEQIQTLSRTLSAKAASGFTFGNVPEH 960
            DLTPLDIDTLPTRQALEQISDFRNTHITTTTFIPEQIQTLSRTLSAKAASGFTFGNVPEH
Sbjct: 901  DLTPLDIDTLPTRQALEQISDFRNTHITTTTFIPEQIQTLSRTLSAKAASGFTFGNVPEH 960

Query: 961  RTGPFRHRAPNGGFFRSPIKTMSSIPYQPTPTLGLNLGNDPDRGTSI 1007
            RTGPFRHRAPNGGFFRSPIKTMSSIPYQPTPTLGLNLGNDPDRGTSI
Sbjct: 961  RTGPFRHRAPNGGFFRSPIKTMSSIPYQPTPTLGLNLGNDPDRGTSI 1007


>gi|55770852 glutamate receptor, ionotropic, delta 1 precursor [Homo
            sapiens]
          Length = 1009

 Score = 1169 bits (3024), Expect = 0.0
 Identities = 568/1010 (56%), Positives = 762/1010 (75%), Gaps = 16/1010 (1%)

Query: 10   LSVW---WSRTWDSANADSIIHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQTEKITFS 66
            L++W   W     S  ADSIIHIGAIF+E+A KDD VF+ AV DL+ N++ILQ+EKIT+S
Sbjct: 4    LTLWLLPWICQCVSVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYS 63

Query: 67   VTFVDGNNPFQAVQEACELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGT 126
            +  ++ NNPFQAVQEAC+LM QGILALV+S GC SA +LQSL DAMHIPHLF+QR+  G+
Sbjct: 64   IKVIEANNPFQAVQEACDLMTQGILALVTSTGCASANALQSLTDAMHIPHLFVQRNPGGS 123

Query: 127  PRSGCGLTRSNRNDDYTLSVRPPVYLHDVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLD 186
            PR+ C L  S   + YTL+ RPPV L+DV+LR+VTE  WQKF++FYDSEYDIRG+Q FLD
Sbjct: 124  PRTACHLNPSPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLD 183

Query: 187  KVSQQGMDVALQKVENNINKMITTLFDTMRIEELNRYRDTLRRAILVMNPATAKSFITEV 246
            + S+ G+DV+LQKV+ NI+ + T+LF TM+ EELNRYRDTLRRAIL+++P  A SFI E 
Sbjct: 184  QASRLGLDVSLQKVDKNISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEA 243

Query: 247  VETNLVAFDCHWIIINEEINDVDVQELVRRSIGRLTIIRQTFPVPQNISQRCFRGNHRIS 306
            VETNL + D HW+ +NEEI+D ++ +LV  ++GR+T++RQ FP  ++ +Q+C R NHRIS
Sbjct: 244  VETNLASKDSHWVFVNEEISDPEILDLVHSALGRMTVVRQIFPSAKD-NQKCTRNNHRIS 302

Query: 307  STLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIRKNSKPWQGG 366
            S LCDP++ + Q ++ISNLY+YD+VL+LANAFH+KLEDRKWHSMASL+CIRK++KPW GG
Sbjct: 303  SLLCDPQEGYLQMLQISNLYLYDSVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWNGG 362

Query: 367  RSMLETIKKGGVSGLTGELEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTGLN 426
            RSML+TIKKG ++GLTG +EF E+  NP V FEILGT Y E  G+ +RKL  W+   GLN
Sbjct: 363  RSMLDTIKKGHITGLTGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDSEKGLN 422

Query: 427  GSLTDKKLENNMRGVVLRVVTVLEEPFVMVSENVLGKPKKYQGFSIDVLDALSNYLGFNY 486
            GSL ++ + + ++G+ L+VVTVLEEPFVMV+EN+LG+PK+Y+GFSIDVLDAL+  LGF Y
Sbjct: 423  GSLQERPMGSRLQGLTLKVVTVLEEPFVMVAENILGQPKRYKGFSIDVLDALAKALGFKY 482

Query: 487  EIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVG 546
            EIY APD +YG    + +WNG++GEL+ KRAD+ ISA+TITP+RE+VVDF+ RYMDYSVG
Sbjct: 483  EIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVG 542

Query: 547  VLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNPPRLQMGSM----TS 602
            +L+++ E+ + +F+  APFD ++WACIA  + +VG+L+++LN +   R Q  +      S
Sbjct: 543  ILIKKPEEKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVRAQSAAQPRPSAS 602

Query: 603  TTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITRIE 662
             TL++++W VYG+FVQQGGE    ++A R++MG+WWLF LIV SSYTANLAAFLT++R++
Sbjct: 603  ATLHSAIWIVYGAFVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMD 662

Query: 663  SSIQSLQDLSKQTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWRMINRSNGSENNV 722
            + I++ QDLSKQ E+ YGTV DSAVYE+ R KG NP E+DS ++++WR I+++ G++N V
Sbjct: 663  NPIRTFQDLSKQVEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADNCV 722

Query: 723  LESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTIGNTVADRGYGIALQHGSPYRD 782
                 GI+K K GNYAF+WD AV+EY A+ D DCS   IGN+++ +GYGIALQHGSPYRD
Sbjct: 723  SSPSEGIRKAKKGNYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQHGSPYRD 782

Query: 783  VFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIKSFAGVFCILAAGI 842
            +FSQRILELQ  GD+D+LK KWWP  G+CDL S    +  G +L + SFAGVFCILA G+
Sbjct: 783  LFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQADGKSLKLHSFAGVFCILAIGL 842

Query: 843  VLSCFIAMLETWWNKRKGSRVPSKEDDKEIDLEHLHRRVNSLCTDDDSPHKQFSTSSIDL 902
            +L+C +A LE WWN  +  +   KE DKE++LE +HRR+NSL  D+D  HKQ S +SI+L
Sbjct: 843  LLACLVAALELWWNSNRCHQETPKE-DKEVNLEQVHRRMNSL-MDEDIAHKQISPASIEL 900

Query: 903  TPLDIDTLPTRQALEQISDFRNTHITTTTFIPEQ-IQTLSRTLSAKAASGFTFGNVPEHR 961
            + L++  L   Q LE   +++NT ++ +TF+PEQ     SRTLS+  +S      +    
Sbjct: 901  SALEMGGLAPTQTLEPTREYQNTQLSVSTFLPEQSSHGTSRTLSSGPSSNLPL-PLSSSA 959

Query: 962  TGP---FRHRAPNGGFFR-SPIKTMSSIPYQPTPTLGLNLGNDPDRGTSI 1007
            T P    +HR+PNGG FR SP+KT   + +QP P   L    D   GTSI
Sbjct: 960  TMPSMQCKHRSPNGGLFRQSPVKTPIPMSFQPVPGGVLPEALDTSHGTSI 1009


>gi|28416444 glutamate receptor, ionotropic, kainate 1 isoform 2
           precursor [Homo sapiens]
          Length = 905

 Score =  366 bits (940), Expect = e-101
 Identities = 257/863 (29%), Positives = 432/863 (50%), Gaps = 65/863 (7%)

Query: 23  ADSIIHIGAIFD----ESAKKDDEVFRTAVGDLNQNEEILQTEKITFSVTFVDGNNPFQA 78
           A  ++ IG IF+    E    ++  F+ AV  +N+N  ++    +T+ +  ++  + F+A
Sbjct: 33  APQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQRINLFDSFEA 92

Query: 79  VQEACELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNR 138
            + AC+ +  G+ AL      +S  ++QS+ +A+ +PH  IQ            L   N 
Sbjct: 93  SRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPH--IQTRWKHPSVDNKDLFYINL 150

Query: 139 NDDYTLSVRPPVYLHDVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQ 198
             DY    R        IL +V  Y W+   + Y+    +  +QE +   S+  + + ++
Sbjct: 151 YPDYAAISR-------AILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIR 203

Query: 199 KVENNINKMITTLFDTMRIEELNRYRDTLRRAILVMNPATAKSFITEVVETNLVAFDCHW 258
           ++ +  NK    L     ++E+ + ++     I   +  TA   + +++   ++    H+
Sbjct: 204 QLPSG-NKDAKPL-----LKEMKKGKEFY--VIFDCSHETAAEILKQILFMGMMTEYYHY 255

Query: 259 IIINEEINDVDVQELVRRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQ 318
                ++  +D+ EL R S   +T  R       ++S    + +         P+     
Sbjct: 256 FFTTLDLFALDL-ELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLD 314

Query: 319 NMEISNLYI-YDTVLLLANAFHKKLEDRKWHSMASLSCIRKNSKPWQGGRSMLETIKKGG 377
            M  +   + YD V ++A A H+  +     +++SL C R   KPW+ G   +  IK+  
Sbjct: 315 GMMTTEAALMYDAVYMVAIASHRASQ----LTVSSLQCHRH--KPWRLGPRFMNLIKEAR 368

Query: 378 VSGLTGELEFGE-NGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTGLNGSLTDKKLEN 436
             GLTG + F + NG   +   +I+     EE   G  K+G WN  +GLN + ++K   +
Sbjct: 369 WDGLTGHITFNKTNGLRKDFDLDIISLK--EE---GTEKIGIWNSNSGLNMTDSNKDKSS 423

Query: 437 NMRGVV----LRVVTVLEEPFVMV--SENVLGKPKKYQGFSIDVLDALSNYLGFNYEIYV 490
           N+   +    L V T+LEEP+VM   S+  L    +++G+ +D+L  LSN LGF Y++ +
Sbjct: 424 NITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKL 483

Query: 491 APDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLR 550
            PD KYG+  + G WNG+V EL+  RAD+ ++ LTIT  RE V+DF+  +M   + +L R
Sbjct: 484 VPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYR 543

Query: 551 RAEKT-VDMFACLAPFDLSLWACIAGTVLLVGLLVYLL------NWLNPPRLQMGS---M 600
           +   T   +F+ L P    +W  +    L V  +++++       W NP      S    
Sbjct: 544 KPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVE 603

Query: 601 TSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITR 660
            + TL NS WF  G+ +QQG E+    L+TR++ G WW F LI+ISSYTANLAAFLT+ R
Sbjct: 604 NNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVER 663

Query: 661 IESSIQSLQDLSKQTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWRMINRSNGSEN 720
           +ES I S  DL+KQT+I YG V D +     +   +      S Y +MW  ++ S     
Sbjct: 664 MESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKI------STYEKMWAFMS-SRQQTA 716

Query: 721 NVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTIGNTVADRGYGIALQHGSPY 780
            V  S  GIQ+V   +YA + ++  +EYV     +C+   IG  +  +GYG+    GSPY
Sbjct: 717 LVRNSDEGIQRVLTTDYALLMESTSIEYV--TQRNCNLTQIGGLIDSKGYGVGTPIGSPY 774

Query: 781 RDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIKSFAGVFCILAA 840
           RD  +  IL+LQ+ G + ++K KWW  NG        +  ++  AL +++  G+F +LAA
Sbjct: 775 RDKITIAILQLQEEGKLHMMKEKWWRGNG-----CPEEDNKEASALGVENIGGIFIVLAA 829

Query: 841 GIVLSCFIAMLETWWNKRKGSRV 863
           G+VLS F+A+ E  +  RK + +
Sbjct: 830 GLVLSVFVAIGEFIYKSRKNNDI 852


>gi|4504117 glutamate receptor, ionotropic, kainate 1 isoform 1
           precursor [Homo sapiens]
          Length = 918

 Score =  362 bits (930), Expect = e-100
 Identities = 257/873 (29%), Positives = 433/873 (49%), Gaps = 70/873 (8%)

Query: 23  ADSIIHIGAIFD----ESAKKDDEVFRTAVGDLNQNEEILQTEKITFSVTFVDGNNPFQA 78
           A  ++ IG IF+    E    ++  F+ AV  +N+N  ++    +T+ +  ++  + F+A
Sbjct: 33  APQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQRINLFDSFEA 92

Query: 79  VQEACELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNR 138
            + AC+ +  G+ AL      +S  ++QS+ +A+ +PH  IQ            L   N 
Sbjct: 93  SRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPH--IQTRWKHPSVDNKDLFYINL 150

Query: 139 NDDYTLSVRPPVYLHDVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQ 198
             DY    R        IL +V  Y W+   + Y+    +  +QE +   S+  + + ++
Sbjct: 151 YPDYAAISR-------AILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIR 203

Query: 199 KVENNINKMITTLFDTMRIEELNRYRDTLRRAILVMNPATAKSFITEVVETNLVAFDCHW 258
           ++ +  NK    L     ++E+ + ++     I   +  TA   + +++   ++    H+
Sbjct: 204 QLPSG-NKDAKPL-----LKEMKKGKEFY--VIFDCSHETAAEILKQILFMGMMTEYYHY 255

Query: 259 IIINEEINDVDVQELVRRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQ 318
                ++  +D+ EL R S   +T  R       ++S    + +         P+     
Sbjct: 256 FFTTLDLFALDL-ELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLD 314

Query: 319 NMEISNLYI-YDTVLLLANAFHKKLEDRKWHSMASLSCIRKNSKPWQGGRSMLETIKKGG 377
            M  +   + YD V ++A A H+  +     +++SL C R   KPW+ G   +  IK+  
Sbjct: 315 GMMTTEAALMYDAVYMVAIASHRASQ----LTVSSLQCHRH--KPWRLGPRFMNLIKEAR 368

Query: 378 VSGLTGELEFGE-NGGNPNVHFEILGTNY-GEELGRGV---------RKLGCWNPVTGLN 426
             GLTG + F + NG   +   +I+     G E   G          +K+G WN  +GLN
Sbjct: 369 WDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSNSGLN 428

Query: 427 GSLTDKKLENNMRGVV----LRVVTVLEEPFVMV--SENVLGKPKKYQGFSIDVLDALSN 480
            + ++K   +N+   +    L V T+LEEP+VM   S+  L    +++G+ +D+L  LSN
Sbjct: 429 MTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSN 488

Query: 481 YLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRY 540
            LGF Y++ + PD KYG+  + G WNG+V EL+  RAD+ ++ LTIT  RE V+DF+  +
Sbjct: 489 ILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPF 548

Query: 541 MDYSVGVLLRRAEKT-VDMFACLAPFDLSLWACIAGTVLLVGLLVYLL------NWLNPP 593
           M   + +L R+   T   +F+ L P    +W  +    L V  +++++       W NP 
Sbjct: 549 MTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPH 608

Query: 594 RLQMGS---MTSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTA 650
                S     + TL NS WF  G+ +QQG E+    L+TR++ G WW F LI+ISSYTA
Sbjct: 609 PCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTA 668

Query: 651 NLAAFLTITRIESSIQSLQDLSKQTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWR 710
           NLAAFLT+ R+ES I S  DL+KQT+I YG V D +     +   +      S Y +MW 
Sbjct: 669 NLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKI------STYEKMWA 722

Query: 711 MINRSNGSENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTIGNTVADRGY 770
            ++ S      V  S  GIQ+V   +YA + ++  +EYV     +C+   IG  +  +GY
Sbjct: 723 FMS-SRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYV--TQRNCNLTQIGGLIDSKGY 779

Query: 771 GIALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIKS 830
           G+    GSPYRD  +  IL+LQ+ G + ++K KWW  NG        +  ++  AL +++
Sbjct: 780 GVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNG-----CPEEDNKEASALGVEN 834

Query: 831 FAGVFCILAAGIVLSCFIAMLETWWNKRKGSRV 863
             G+F +LAAG+VLS F+A+ E  +  RK + +
Sbjct: 835 IGGIFIVLAAGLVLSVFVAIGEFIYKSRKNNDI 867


>gi|11386137 glutamate receptor, ionotropic, kainate 2 isoform 1
           precursor [Homo sapiens]
          Length = 908

 Score =  357 bits (916), Expect = 3e-98
 Identities = 258/877 (29%), Positives = 435/877 (49%), Gaps = 80/877 (9%)

Query: 20  SANADSIIHIGAIFD--ESAKKDDE--VFRTAVGDLNQNEEILQTEKITFSVTFVDGNNP 75
           S     ++  G IF+  ES     E   FR AV  +N+N  +L    +T+    ++  + 
Sbjct: 29  SQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDS 88

Query: 76  FQAVQEACELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTR 135
           F+A ++AC+ ++ G+ A+      +SA ++QS+ +A+ +PH+          ++      
Sbjct: 89  FEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHI----------QTRWKHQV 138

Query: 136 SNRNDDYTLSVRPPVY-LHDVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMD 194
           S+  D + +S+ P    L   IL +V  + W+   + YD    +  +QE +   S+  + 
Sbjct: 139 SDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLR 198

Query: 195 VALQKVENNINKMITTLFDTMRIEELNRYRDTLRR-AILVMNPATAKSFITEVVETNLVA 253
           + ++++  +       L +  R +E +   D     A  ++  A A   +TE        
Sbjct: 199 LKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYY------ 252

Query: 254 FDCHWIIINEEINDVDVQELVRRSIGRLTIIR-------QTFPVPQNISQRCFRGNHRIS 306
              H+I    ++  +DV E  R S   +T  R       Q   + +  S    +   +  
Sbjct: 253 ---HYIFTTLDLFALDV-EPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPD 308

Query: 307 STLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIRKNSKPWQGG 366
           S L D        M      +YD V +++ A    ++     +++SL C R   KPW+ G
Sbjct: 309 SGLLDGF------MTTDAALMYDAVHVVSVA----VQQFPQMTVSSLQCNRH--KPWRFG 356

Query: 367 RSMLETIKKGGVSGLTGELEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTGLN 426
              +  IK+    GLTG + F +  G     F++   +  EE   G+ K+G W+P +GLN
Sbjct: 357 TRFMSLIKEAHWEGLTGRITFNKTNGL-RTDFDLDVISLKEE---GLEKIGTWDPASGLN 412

Query: 427 GSLTDK----KLENNMRGVVLRVVTVLEEPFVMV--SENVLGKPKKYQGFSIDVLDALSN 480
            + + K     + +++    L V T+LEEP+V+   S+  L    +++G+ ID+L  LS 
Sbjct: 413 MTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELST 472

Query: 481 YLGFNYEIYVAPDHKYGSPQE-DGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTR 539
            LGF YEI +  D KYG+  + +G WNG+V EL+  +AD+ ++ L IT  RE V+DF+  
Sbjct: 473 ILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKP 532

Query: 540 YMDYSVGVLLRRAEKT-VDMFACLAPFDLSLWACIAGTVLLVGLLVYLL------NWLNP 592
           +M   + +L R+   T   +F+ L P    +W  I    L V  +++++       W NP
Sbjct: 533 FMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNP 592

Query: 593 PRLQMGS---MTSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYT 649
                 S     + TL NS WF  G+ +QQG E+    L+TR++ G WW F LI+ISSYT
Sbjct: 593 HPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYT 652

Query: 650 ANLAAFLTITRIESSIQSLQDLSKQTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMW 709
           ANLAAFLT+ R+ES I S  DL+KQT+I YG V D A     +   +      S Y +MW
Sbjct: 653 ANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKI------STYDKMW 706

Query: 710 RMINRSNGSENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTIGNTVADRG 769
             ++ S      V  ++ GIQ+V   +YAF+ ++  +E+V     +C+   IG  +  +G
Sbjct: 707 AFMS-SRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFV--TQRNCNLTQIGGLIDSKG 763

Query: 770 YGIALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIK 829
           YG+    GSPYRD  +  IL+LQ+ G + ++K KWW  NG        +  ++  AL ++
Sbjct: 764 YGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNG-----CPEEESKEASALGVQ 818

Query: 830 SFAGVFCILAAGIVLSCFIAMLETWWNKRKGSRVPSK 866
           +  G+F +LAAG+VLS F+A+ E  +  +K +++  +
Sbjct: 819 NIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKR 855


>gi|28559003 glutamate receptor, ionotropic, kainate 2 isoform 2
           precursor [Homo sapiens]
          Length = 869

 Score =  357 bits (915), Expect = 4e-98
 Identities = 258/874 (29%), Positives = 434/874 (49%), Gaps = 80/874 (9%)

Query: 20  SANADSIIHIGAIFD--ESAKKDDE--VFRTAVGDLNQNEEILQTEKITFSVTFVDGNNP 75
           S     ++  G IF+  ES     E   FR AV  +N+N  +L    +T+    ++  + 
Sbjct: 29  SQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDS 88

Query: 76  FQAVQEACELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTR 135
           F+A ++AC+ ++ G+ A+      +SA ++QS+ +A+ +PH+          ++      
Sbjct: 89  FEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHI----------QTRWKHQV 138

Query: 136 SNRNDDYTLSVRPPVY-LHDVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMD 194
           S+  D + +S+ P    L   IL +V  + W+   + YD    +  +QE +   S+  + 
Sbjct: 139 SDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLR 198

Query: 195 VALQKVENNINKMITTLFDTMRIEELNRYRDTLRR-AILVMNPATAKSFITEVVETNLVA 253
           + ++++  +       L +  R +E +   D     A  ++  A A   +TE        
Sbjct: 199 LKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYY------ 252

Query: 254 FDCHWIIINEEINDVDVQELVRRSIGRLTIIR-------QTFPVPQNISQRCFRGNHRIS 306
              H+I    ++  +DV E  R S   +T  R       Q   + +  S    +   +  
Sbjct: 253 ---HYIFTTLDLFALDV-EPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPD 308

Query: 307 STLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIRKNSKPWQGG 366
           S L D        M      +YD V +++ A    ++     +++SL C R   KPW+ G
Sbjct: 309 SGLLDGF------MTTDAALMYDAVHVVSVA----VQQFPQMTVSSLQCNRH--KPWRFG 356

Query: 367 RSMLETIKKGGVSGLTGELEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTGLN 426
              +  IK+    GLTG + F +  G     F++   +  EE   G+ K+G W+P +GLN
Sbjct: 357 TRFMSLIKEAHWEGLTGRITFNKTNGL-RTDFDLDVISLKEE---GLEKIGTWDPASGLN 412

Query: 427 GSLTDK----KLENNMRGVVLRVVTVLEEPFVMV--SENVLGKPKKYQGFSIDVLDALSN 480
            + + K     + +++    L V T+LEEP+V+   S+  L    +++G+ ID+L  LS 
Sbjct: 413 MTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELST 472

Query: 481 YLGFNYEIYVAPDHKYGSPQE-DGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTR 539
            LGF YEI +  D KYG+  + +G WNG+V EL+  +AD+ ++ L IT  RE V+DF+  
Sbjct: 473 ILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKP 532

Query: 540 YMDYSVGVLLRRAEKT-VDMFACLAPFDLSLWACIAGTVLLVGLLVYLL------NWLNP 592
           +M   + +L R+   T   +F+ L P    +W  I    L V  +++++       W NP
Sbjct: 533 FMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNP 592

Query: 593 PRLQMGS---MTSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYT 649
                 S     + TL NS WF  G+ +QQG E+    L+TR++ G WW F LI+ISSYT
Sbjct: 593 HPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYT 652

Query: 650 ANLAAFLTITRIESSIQSLQDLSKQTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMW 709
           ANLAAFLT+ R+ES I S  DL+KQT+I YG V D A     +   +      S Y +MW
Sbjct: 653 ANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKI------STYDKMW 706

Query: 710 RMINRSNGSENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTIGNTVADRG 769
             ++ S      V  ++ GIQ+V   +YAF+ ++  +E+V     +C+   IG  +  +G
Sbjct: 707 AFMS-SRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFV--TQRNCNLTQIGGLIDSKG 763

Query: 770 YGIALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIK 829
           YG+    GSPYRD  +  IL+LQ+ G + ++K KWW  NG        +  ++  AL ++
Sbjct: 764 YGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNG-----CPEEESKEASALGVQ 818

Query: 830 SFAGVFCILAAGIVLSCFIAMLETWWNKRKGSRV 863
           +  G+F +LAAG+VLS F+A+ E  +  +K +++
Sbjct: 819 NIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQL 852


>gi|167001419 glutamate receptor, ionotropic, AMPA 1 isoform 1 [Homo
           sapiens]
          Length = 906

 Score =  356 bits (914), Expect = 5e-98
 Identities = 235/870 (27%), Positives = 425/870 (48%), Gaps = 79/870 (9%)

Query: 21  ANADSIIHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQTEKITFSVTFVDGNNPFQAVQ 80
           AN  + I IG +F     ++   FR A+  L +  ++L        +  V+ ++ F+   
Sbjct: 19  ANFPNNIQIGGLFPNQQSQEHAAFRFALSQLTEPPKLLP------QIDIVNISDSFEMTY 72

Query: 81  EACELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRS---N 137
             C   ++G+ A+       +   L S   A+H+                C +T S   +
Sbjct: 73  RFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHV----------------CFITPSFPVD 116

Query: 138 RNDDYTLSVRPPVYLHDVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVAL 197
            ++ + L +RP   L D ++ ++  Y WQKF+  YD++  +  +Q+ LD  +++   V  
Sbjct: 117 TSNQFVLQLRPE--LQDALISIIDHYKWQKFVYIYDADRGLSVLQKVLDTAAEKNWQVTA 174

Query: 198 QKVENNINKMITTLFDTMRIEELNRYRDTLRRAILVMNPATAKSFITEVVETNLVAFDCH 257
             +     +    LF     ++L + ++ L   ++        + + ++++        H
Sbjct: 175 VNILTTTEEGYRMLF-----QDLEKKKERL--VVVDCESERLNAILGQIIKLEKNGIGYH 227

Query: 258 WIIINEEINDVDVQELVRR--SIGRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDP 315
           +I+ N    D+D+ +      ++    ++  T  +P  I Q+    + R   T  D K P
Sbjct: 228 YILANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPAKIMQQWKNSDAR-DHTRVDWKRP 286

Query: 316 FAQNMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLS--CIRKNSKPWQGGRSMLETI 373
                + ++   YD V ++A AF      R   S    +  C+   + PW  G  +   +
Sbjct: 287 -----KYTSALTYDGVKVMAEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRAL 341

Query: 374 KKGGVSGLTGELEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTGLNGSLTDKK 433
           ++    GLTG ++F E G   N    ++   +      G+RK+G WN       + TD +
Sbjct: 342 QQVRFEGLTGNVQFNEKGRRTNYTLHVIEMKHD-----GIRKIGYWNEDDKFVPAATDAQ 396

Query: 434 LENNMRGVVLR---VVTVLEEPFVMVSENV--LGKPKKYQGFSIDVLDALSNYLGFNYEI 488
              +   V  R   V T+LE+P+VM+ +N        +Y+G+ +++   ++ ++G++Y +
Sbjct: 397 AGGDNSSVQNRTYIVTTILEDPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRL 456

Query: 489 YVAPDHKYGSPQEDG-TWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGV 547
            +  D KYG+   D   WNG+VGELV+ RAD+ ++ LTIT  RE V+DF+  +M   + +
Sbjct: 457 EIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISI 516

Query: 548 LLRRAEKTVD-MFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNP-----PRLQMGSMT 601
           ++++ +K+   +F+ L P    +W CI    + V ++++L++  +P        + G   
Sbjct: 517 MIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQ 576

Query: 602 STT-------LYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAA 654
           +T+       ++NS+WF  G+F+QQG ++   +L+ R++ G WW F LI+ISSYTANLAA
Sbjct: 577 TTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAA 636

Query: 655 FLTITRIESSIQSLQDLSKQTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWRMINR 714
           FLT+ R+ S I+S +DL+KQTEI YGT+   +  E  R   +  FE+      MW  +  
Sbjct: 637 FLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEK------MWTYMKS 690

Query: 715 SNGS--ENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTIGNTVADRGYGI 772
           +  S       E    ++K K G YA++ ++ + EY+    P C    +G  +  +GYGI
Sbjct: 691 AEPSVFVRTTEEGMIRVRKSK-GKYAYLLESTMNEYIEQRKP-CDTMKVGGNLDSKGYGI 748

Query: 773 ALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIKSFA 832
           A   GS  R+  +  +L+L + G +D LK+KWW   G+C      D+K K  AL + + A
Sbjct: 749 ATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKGECG-SGGGDSKDKTSALSLSNVA 807

Query: 833 GVFCILAAGIVLSCFIAMLETWWNKRKGSR 862
           GVF IL  G+ L+  +A++E  +  R  S+
Sbjct: 808 GVFYILIGGLGLAMLVALIEFCYKSRSESK 837


>gi|167001484 glutamate receptor, ionotropic, AMPA 1 isoform 2 [Homo
           sapiens]
          Length = 906

 Score =  354 bits (909), Expect = 2e-97
 Identities = 235/870 (27%), Positives = 423/870 (48%), Gaps = 79/870 (9%)

Query: 21  ANADSIIHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQTEKITFSVTFVDGNNPFQAVQ 80
           AN  + I IG +F     ++   FR A+  L +  ++L        +  V+ ++ F+   
Sbjct: 19  ANFPNNIQIGGLFPNQQSQEHAAFRFALSQLTEPPKLLP------QIDIVNISDSFEMTY 72

Query: 81  EACELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRS---N 137
             C   ++G+ A+       +   L S   A+H+                C +T S   +
Sbjct: 73  RFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHV----------------CFITPSFPVD 116

Query: 138 RNDDYTLSVRPPVYLHDVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVAL 197
            ++ + L +RP   L D ++ ++  Y WQKF+  YD++  +  +Q+ LD  +++   V  
Sbjct: 117 TSNQFVLQLRPE--LQDALISIIDHYKWQKFVYIYDADRGLSVLQKVLDTAAEKNWQVTA 174

Query: 198 QKVENNINKMITTLFDTMRIEELNRYRDTLRRAILVMNPATAKSFITEVVETNLVAFDCH 257
             +     +    LF     ++L + ++ L   ++        + + ++++        H
Sbjct: 175 VNILTTTEEGYRMLF-----QDLEKKKERL--VVVDCESERLNAILGQIIKLEKNGIGYH 227

Query: 258 WIIINEEINDVDVQELVRR--SIGRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDP 315
           +I+ N    D+D+ +      ++    ++  T  +P  I Q+    + R   T  D K P
Sbjct: 228 YILANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPAKIMQQWKNSDAR-DHTRVDWKRP 286

Query: 316 FAQNMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLS--CIRKNSKPWQGGRSMLETI 373
                + ++   YD V ++A AF      R   S    +  C+   + PW  G  +   +
Sbjct: 287 -----KYTSALTYDGVKVMAEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRAL 341

Query: 374 KKGGVSGLTGELEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTGLNGSLTDKK 433
           ++    GLTG ++F E G   N    ++   +      G+RK+G WN       + TD +
Sbjct: 342 QQVRFEGLTGNVQFNEKGRRTNYTLHVIEMKHD-----GIRKIGYWNEDDKFVPAATDAQ 396

Query: 434 LENNMRGVVLR---VVTVLEEPFVMVSENV--LGKPKKYQGFSIDVLDALSNYLGFNYEI 488
              +   V  R   V T+LE+P+VM+ +N        +Y+G+ +++   ++ ++G++Y +
Sbjct: 397 AGGDNSSVQNRTYIVTTILEDPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRL 456

Query: 489 YVAPDHKYGSPQEDG-TWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGV 547
            +  D KYG+   D   WNG+VGELV+ RAD+ ++ LTIT  RE V+DF+  +M   + +
Sbjct: 457 EIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISI 516

Query: 548 LLRRAEKTVD-MFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNP-----PRLQMGSMT 601
           ++++ +K+   +F+ L P    +W CI    + V ++++L++  +P        + G   
Sbjct: 517 MIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQ 576

Query: 602 STT-------LYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAA 654
           +T+       ++NS+WF  G+F+QQG ++   +L+ R++ G WW F LI+ISSYTANLAA
Sbjct: 577 TTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAA 636

Query: 655 FLTITRIESSIQSLQDLSKQTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWRMINR 714
           FLT+ R+ S I+S +DL+KQTEI YGT+   +  E  R   +  FE+      MW  +  
Sbjct: 637 FLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEK------MWTYMKS 690

Query: 715 SNGS--ENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTIGNTVADRGYGI 772
           +  S       E    ++K K G YA++ ++ + EY+    P C    +G  +  +GYGI
Sbjct: 691 AEPSVFVRTTEEGMIRVRKSK-GKYAYLLESTMNEYIEQRKP-CDTMKVGGNLDSKGYGI 748

Query: 773 ALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIKSFA 832
           A   GS  R   +  +L+L + G +D LK KWW   G+C    S  +K K  AL + + A
Sbjct: 749 ATPKGSALRGPVNLAVLKLSEQGVLDKLKSKWWYDKGECGSKDS-GSKDKTSALSLSNVA 807

Query: 833 GVFCILAAGIVLSCFIAMLETWWNKRKGSR 862
           GVF IL  G+ L+  +A++E  +  R  S+
Sbjct: 808 GVFYILIGGLGLAMLVALIEFCYKSRSESK 837


>gi|134304848 glutamate receptor, ionotropic, AMPA 2 isoform 2
           precursor [Homo sapiens]
          Length = 883

 Score =  348 bits (893), Expect = 1e-95
 Identities = 242/863 (28%), Positives = 420/863 (48%), Gaps = 80/863 (9%)

Query: 27  IHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQTEKITFSVTFVDGNNPFQAVQEACELM 86
           I IG +F   A ++   FR  +   + +E      ++T  +  ++  N F      C   
Sbjct: 27  IQIGGLFPRGADQEYSAFRVGMVQFSTSEF-----RLTPHIDNLEVANSFAVTNAFCSQF 81

Query: 87  NQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRNDDYTLSV 146
           ++G+ A+       S  ++ S    +H+  +     T GT               + + +
Sbjct: 82  SRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGT-------------HPFVIQM 128

Query: 147 RPPVYLHDVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQKVENNIN- 205
           RP   L   +L ++  Y W KF   YDS+  +  +Q  LD  +++   V    V N  N 
Sbjct: 129 RPD--LKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINND 186

Query: 206 ---KMITTLFDTMRIEELNRYRDTLRRAILVMNPATAKSFITEVVETNLVAFDCHWIIIN 262
              +M  +LF  + +++        RR IL          + +V+         H+II N
Sbjct: 187 KKDEMYRSLFQDLELKKE-------RRVILDCERDKVNDIVDQVITIGKHVKGYHYIIAN 239

Query: 263 EEINDVDVQELV--RRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQNM 320
               D D+ ++     ++    I+     +     +R         STL + + P A   
Sbjct: 240 LGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERW--------STLEEKEYPGAHTT 291

Query: 321 EI--SNLYIYDTVLLLANAFHKKLEDRKWHSMASLS--CIRKNSKPWQGGRSMLETIKKG 376
            I  ++   YD V ++  AF    + R   S    +  C+   + PW  G  +   +K+ 
Sbjct: 292 TIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQV 351

Query: 377 GVSGLTGELEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTGLNGSLTDKKLEN 436
            V GL+G ++F +NG   N    I+     E    G RK+G W+ V  +  +LT+    N
Sbjct: 352 QVEGLSGNIKFDQNGKRINYTINIM-----ELKTNGPRKIGYWSEVDKMVVTLTELPSGN 406

Query: 437 NMRGV---VLRVVTVLEEPFVMVSEN--VLGKPKKYQGFSIDVLDALSNYLGFNYEIYVA 491
           +  G+    + V T+LE P+VM+ +N  +L   ++Y+G+ +D+   ++ + GF Y++ + 
Sbjct: 407 DTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIV 466

Query: 492 PDHKYGSPQEDGT-WNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLR 550
            D KYG+   D   WNG+VGELV+ +ADI I+ LTIT  RE V+DF+  +M   + ++++
Sbjct: 467 GDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIK 526

Query: 551 RAEKTVD-MFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNP-----PRLQMGSMTSTT 604
           + +K+   +F+ L P    +W CI    + V ++++L++  +P        + G  T ++
Sbjct: 527 KPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSS 586

Query: 605 -------LYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLT 657
                  ++NS+WF  G+F++QG ++   +L+ R++ G WW F LI+ISSYTANLAAFLT
Sbjct: 587 ESTNEFGIFNSLWFSLGAFMRQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLT 646

Query: 658 ITRIESSIQSLQDLSKQTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWRMINRSNG 717
           + R+ S I+S +DLSKQTEI YGT+   +  E  R   +      +++ +MW  +  +  
Sbjct: 647 VERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKI------AVFDKMWTYMRSAEP 700

Query: 718 S--ENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTIGNTVADRGYGIALQ 775
           S       E  A ++K K G YA++ ++ + EY+    P C    +G  +  +GYGIA  
Sbjct: 701 SVFVRTTAEGVARVRKSK-GKYAYLLESTMNEYIEQRKP-CDTMKVGGNLDSKGYGIATP 758

Query: 776 HGSPYRDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIKSFAGVF 835
            GS  R+  +  +L+L + G +D LK+KWW   G+C      D+K+K  AL + + AGVF
Sbjct: 759 KGSSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECG-SGGGDSKEKTSALSLSNVAGVF 817

Query: 836 CILAAGIVLSCFIAMLETWWNKR 858
            IL  G+ L+  +A++E  +  R
Sbjct: 818 YILVGGLGLAMLVALIEFCYKSR 840


>gi|74275354 glutamate receptor, ionotropic, AMPA 2 isoform 1
           precursor [Homo sapiens]
          Length = 883

 Score =  347 bits (889), Expect = 4e-95
 Identities = 242/863 (28%), Positives = 419/863 (48%), Gaps = 80/863 (9%)

Query: 27  IHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQTEKITFSVTFVDGNNPFQAVQEACELM 86
           I IG +F   A ++   FR  +   + +E      ++T  +  ++  N F      C   
Sbjct: 27  IQIGGLFPRGADQEYSAFRVGMVQFSTSEF-----RLTPHIDNLEVANSFAVTNAFCSQF 81

Query: 87  NQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRNDDYTLSV 146
           ++G+ A+       S  ++ S    +H+  +     T GT               + + +
Sbjct: 82  SRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGT-------------HPFVIQM 128

Query: 147 RPPVYLHDVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQKVENNIN- 205
           RP   L   +L ++  Y W KF   YDS+  +  +Q  LD  +++   V    V N  N 
Sbjct: 129 RPD--LKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINND 186

Query: 206 ---KMITTLFDTMRIEELNRYRDTLRRAILVMNPATAKSFITEVVETNLVAFDCHWIIIN 262
              +M  +LF  + +++        RR IL          + +V+         H+II N
Sbjct: 187 KKDEMYRSLFQDLELKKE-------RRVILDCERDKVNDIVDQVITIGKHVKGYHYIIAN 239

Query: 263 EEINDVDVQELV--RRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQNM 320
               D D+ ++     ++    I+     +     +R         STL + + P A   
Sbjct: 240 LGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERW--------STLEEKEYPGAHTT 291

Query: 321 EI--SNLYIYDTVLLLANAFHKKLEDRKWHSMASLS--CIRKNSKPWQGGRSMLETIKKG 376
            I  ++   YD V ++  AF    + R   S    +  C+   + PW  G  +   +K+ 
Sbjct: 292 TIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQV 351

Query: 377 GVSGLTGELEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTGLNGSLTDKKLEN 436
            V GL+G ++F +NG   N    I+     E    G RK+G W+ V  +  +LT+    N
Sbjct: 352 QVEGLSGNIKFDQNGKRINYTINIM-----ELKTNGPRKIGYWSEVDKMVVTLTELPSGN 406

Query: 437 NMRGV---VLRVVTVLEEPFVMVSEN--VLGKPKKYQGFSIDVLDALSNYLGFNYEIYVA 491
           +  G+    + V T+LE P+VM+ +N  +L   ++Y+G+ +D+   ++ + GF Y++ + 
Sbjct: 407 DTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIV 466

Query: 492 PDHKYGSPQEDGT-WNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLR 550
            D KYG+   D   WNG+VGELV+ +ADI I+ LTIT  RE V+DF+  +M   + ++++
Sbjct: 467 GDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIK 526

Query: 551 RAEKTVD-MFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNP-----PRLQMGSMTSTT 604
           + +K+   +F+ L P    +W CI    + V ++++L++  +P        + G  T ++
Sbjct: 527 KPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSS 586

Query: 605 -------LYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLT 657
                  ++NS+WF  G+F++QG ++   +L+ R++ G WW F LI+ISSYTANLAAFLT
Sbjct: 587 ESTNEFGIFNSLWFSLGAFMRQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLT 646

Query: 658 ITRIESSIQSLQDLSKQTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWRMINRSNG 717
           + R+ S I+S +DLSKQTEI YGT+   +  E  R   +      +++ +MW  +  +  
Sbjct: 647 VERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKI------AVFDKMWTYMRSAEP 700

Query: 718 S--ENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTIGNTVADRGYGIALQ 775
           S       E  A ++K K G YA++ ++ + EY+    P C    +G  +  +GYGIA  
Sbjct: 701 SVFVRTTAEGVARVRKSK-GKYAYLLESTMNEYIEQRKP-CDTMKVGGNLDSKGYGIATP 758

Query: 776 HGSPYRDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIKSFAGVF 835
            GS  R   +  +L+L + G +D LK+KWW   G+C    S  +K+K  AL + + AGVF
Sbjct: 759 KGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDS-GSKEKTSALSLSNVAGVF 817

Query: 836 CILAAGIVLSCFIAMLETWWNKR 858
            IL  G+ L+  +A++E  +  R
Sbjct: 818 YILVGGLGLAMLVALIEFCYKSR 840


>gi|28605145 glutamate receptor, ionotropic, kainate 3 precursor
           [Homo sapiens]
          Length = 919

 Score =  345 bits (886), Expect = 9e-95
 Identities = 258/888 (29%), Positives = 426/888 (47%), Gaps = 82/888 (9%)

Query: 2   EVFPFLLVLSVWWSRTWDSANADSIIHIGAIFD-------ESAKKDDEVFRTAVGDLNQN 54
           E +  LLV + W     DS     +I IG IF+       +    ++  FR +   +N+N
Sbjct: 14  EYWAGLLVCAFWIP---DSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRN 70

Query: 55  EEILQTEKITFSVTFVDGNNPFQAVQEACELMNQGILALVSSIGCTSAGSLQSLADAMHI 114
             +L    +T+ +  +  ++ F+A ++AC+ +  G++A+      +   ++QS+ +A+ +
Sbjct: 71  RTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEV 130

Query: 115 PHLFIQRSTAGTPRSGCGLTRSNRNDDYTLSVRPPVYLHDVILRVVTEYAWQKFIIFYDS 174
           PH  IQ      P         N   DY         L   IL +V    W+   + YD 
Sbjct: 131 PH--IQLRWKHHPLDNKDTFYVNLYPDYAS-------LSHAILDLVQYLKWRSATVVYDD 181

Query: 175 EYDIRGIQEFLDKVSQQGMDVALQKVENNINKMITTLFDTMRIEELNRYRDTLRRAILVM 234
              +  +QE +   S+  + + ++++  + +     L      +E+ R R+   R I   
Sbjct: 182 STGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLL------KEMKRGREF--RIIFDC 233

Query: 235 NPATAKSFITEVVETNLVAFDCHWIIINEEINDVDVQELVRRSIGRLTIIR-------QT 287
           +   A   + + +   ++    H+I    ++  +D+ E  R S   LT  R         
Sbjct: 234 SHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDL-EPYRYSGVNLTGFRILNVDNPHV 292

Query: 288 FPVPQNISQRCFRGNHRISSTLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKKLEDRKW 347
             + +  S    +   R  S L D        M      +YD V +++  + +  +    
Sbjct: 293 SAIVEKWSMERLQAAPRSESGLLDGV------MMTDAALLYDAVHIVSVCYQRAPQ---- 342

Query: 348 HSMASLSCIRKNSKPWQGGRSMLETIKKGGVSGLTGELEFGENGGNPNVHFEILGTNYGE 407
            ++ SL C R   K W+ G   +  IK+    GLTG + F +  G     F++   +  E
Sbjct: 343 MTVNSLQCHRH--KAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGL-RTDFDLDIISLKE 399

Query: 408 ELGRGVRKLGCWNPVTGLNGSLTDK----KLENNMRGVVLRVVTVLEEPFVMV--SENVL 461
           +   G+ K+G W+P  GLN +   K     + +++    L V TVLEEPFVM   S+  L
Sbjct: 400 D---GLEKVGVWSPADGLNITEVAKGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTL 456

Query: 462 GKPKKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGI 521
               +++G+ ID+L  L++ LGF+YEI +  D KYG+  + G WNG+V EL+  +AD+ +
Sbjct: 457 YGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAV 516

Query: 522 SALTITPDRENVVDFTTRYMDYSVGVLLRRAEKT-VDMFACLAPFDLSLWACIAGTVLLV 580
           + LTIT  RE  +DF+  +M   V +L R+   T   +F+ L P    +W  +    L V
Sbjct: 517 APLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGV 576

Query: 581 GLLVYLL------NWLNPPRLQMGSMT---STTLYNSMWFVYGSFVQQGGEVPYTTLATR 631
             +++++       W +      GS     + TL NS WF  GS +QQG E+    L+TR
Sbjct: 577 SCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTR 636

Query: 632 MMMGAWWLFALIVISSYTANLAAFLTITRIESSIQSLQDLSKQTEIPYGTVLDSAVYEHV 691
           ++ G WW F LI+ISSYTANLAAFLT+ R+ES I S  DL+KQT+I YG V D A     
Sbjct: 637 IIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFF 696

Query: 692 RMKGLNPFERDSMYSQMWRMINRSNGSENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAI 751
           +   ++ FE+      MW  +  S+     V  ++ GIQ+    +YA + ++  +EYV  
Sbjct: 697 KKSKISTFEK------MWAFM--SSKPSALVKNNEEGIQRALTADYALLMESTTIEYV-- 746

Query: 752 NDPDCSFYTIGNTVADRGYGIALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKNGQC 811
              +C+   IG  +  +GYGI    GSPYRD  +  IL+LQ+   + I+K KWW  +G  
Sbjct: 747 TQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSG-- 804

Query: 812 DLYSSVDTKQKGGALDIKSFAGVFCILAAGIVLSCFIAMLETWWNKRK 859
                 +  ++  AL I+   G+F +LAAG+VLS  +A+ E  +  RK
Sbjct: 805 ---CPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRK 849


>gi|163659858 glutamate receptor, ionotrophic, AMPA 3 isoform 2
           precursor [Homo sapiens]
          Length = 894

 Score =  341 bits (875), Expect = 2e-93
 Identities = 242/869 (27%), Positives = 423/869 (48%), Gaps = 80/869 (9%)

Query: 27  IHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQTEK---ITFSVTFVDGNNPFQAVQEAC 83
           I IG +F  +  ++   FR AV   N N+    TEK   + + V  +D +N F      C
Sbjct: 34  ISIGGLFMRNTVQEHSAFRFAVQLYNTNQNT--TEKPFHLNYHVDHLDSSNSFSVTNAFC 91

Query: 84  ELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRNDDYT 143
              ++G+ A+       S  +L S   A+H   +     T   P        ++ +  + 
Sbjct: 92  SQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFV-----TPSFP--------TDADVQFV 138

Query: 144 LSVRPPVYLHDVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQKVENN 203
           + +RP   L   IL ++  Y W+KF+  YD+E     +Q  ++   Q    V  + V N 
Sbjct: 139 IQMRPA--LKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGN- 195

Query: 204 INKMITTLFDTMRI-EELNRYRDTLRRAILVMNPATAKSFITEVVETNLVAFDCHWIIIN 262
               I  + +  RI EE++R ++  +R ++        + + +VV     +   H+++ N
Sbjct: 196 ----IKDVQEFRRIIEEMDRRQE--KRYLIDCEVERINTILEQVVILGKHSRGYHYMLAN 249

Query: 263 EEINDVDVQELVR--RSIGRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQN- 319
               D+ ++ ++    +I    I+    P+ Q   QR  R + R        + P A+N 
Sbjct: 250 LGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDER--------EFPEAKNA 301

Query: 320 -MEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLS--CIRKNSKPWQGGRSMLETIKKG 376
            ++ ++   +D +L++A AF      R   S    +  C+   + PW  G  +   +K  
Sbjct: 302 PLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMV 361

Query: 377 GVSGLTGELEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTGLNGSLTDKKLEN 436
            V G+TG ++F   G   N   ++      E    G RK G WN         +D+++ N
Sbjct: 362 QVQGMTGNIQFDTYGRRTNYTIDVY-----EMKVSGSRKAGYWNEYERFV-PFSDQQISN 415

Query: 437 NMRGVVLR---VVTVLEEPFVMVSEN--VLGKPKKYQGFSIDVLDALSNYLGFNYEIYVA 491
           +      R   V T+LE P+VM  +N   L   ++Y+G+ +D+   ++ ++   Y++ + 
Sbjct: 416 DSASSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIV 475

Query: 492 PDHKYGSPQ-EDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLR 550
            D KYG+   E   WNG+VGELV+ RADI ++ LTIT  RE V+DF+  +M   + ++++
Sbjct: 476 GDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIK 535

Query: 551 RAEKTVD-MFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNP--------------PRL 595
           + +K+   +F+ L P    +W CI    + V ++++L++  +P              P+ 
Sbjct: 536 KPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQS 595

Query: 596 QMGSMTSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAF 655
                    ++NS+WF  G+F+QQG ++   +L+ R++ G WW F LI+ISSYTANLAAF
Sbjct: 596 PPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAF 655

Query: 656 LTITRIESSIQSLQDLSKQTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWRMINRS 715
           LT+ R+ S I+S +DL+KQTEI YGT+   +  E  R   +      ++Y +MW  +  +
Sbjct: 656 LTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKI------AVYEKMWSYMKSA 709

Query: 716 NGS--ENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTIGNTVADRGYGIA 773
             S       +  A ++K K G +AF+ ++ + EY+    P C    +G  +  +GYG+A
Sbjct: 710 EPSVFTKTTADGVARVRKSK-GKFAFLLESTMNEYIEQRKP-CDTMKVGGNLDSKGYGVA 767

Query: 774 LQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIKSFAG 833
              GS   +  +  +L+L + G +D LK+KWW   G+C      D+K K  AL + + AG
Sbjct: 768 TPKGSALGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECG-SGGGDSKDKTSALSLSNVAG 826

Query: 834 VFCILAAGIVLSCFIAMLETWWNKRKGSR 862
           VF IL  G+ L+  +A++E  +  R  S+
Sbjct: 827 VFYILVGGLGLAMMVALIEFCYKSRAESK 855


>gi|163659856 glutamate receptor, ionotrophic, AMPA 3 isoform 1
           precursor [Homo sapiens]
          Length = 894

 Score =  340 bits (871), Expect = 5e-93
 Identities = 242/869 (27%), Positives = 422/869 (48%), Gaps = 80/869 (9%)

Query: 27  IHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQTEK---ITFSVTFVDGNNPFQAVQEAC 83
           I IG +F  +  ++   FR AV   N N+    TEK   + + V  +D +N F      C
Sbjct: 34  ISIGGLFMRNTVQEHSAFRFAVQLYNTNQNT--TEKPFHLNYHVDHLDSSNSFSVTNAFC 91

Query: 84  ELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRNDDYT 143
              ++G+ A+       S  +L S   A+H   +     T   P        ++ +  + 
Sbjct: 92  SQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFV-----TPSFP--------TDADVQFV 138

Query: 144 LSVRPPVYLHDVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQKVENN 203
           + +RP   L   IL ++  Y W+KF+  YD+E     +Q  ++   Q    V  + V N 
Sbjct: 139 IQMRPA--LKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGN- 195

Query: 204 INKMITTLFDTMRI-EELNRYRDTLRRAILVMNPATAKSFITEVVETNLVAFDCHWIIIN 262
               I  + +  RI EE++R ++  +R ++        + + +VV     +   H+++ N
Sbjct: 196 ----IKDVQEFRRIIEEMDRRQE--KRYLIDCEVERINTILEQVVILGKHSRGYHYMLAN 249

Query: 263 EEINDVDVQELVR--RSIGRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQN- 319
               D+ ++ ++    +I    I+    P+ Q   QR  R + R        + P A+N 
Sbjct: 250 LGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDER--------EFPEAKNA 301

Query: 320 -MEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLS--CIRKNSKPWQGGRSMLETIKKG 376
            ++ ++   +D +L++A AF      R   S    +  C+   + PW  G  +   +K  
Sbjct: 302 PLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMV 361

Query: 377 GVSGLTGELEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTGLNGSLTDKKLEN 436
            V G+TG ++F   G   N   ++      E    G RK G WN         +D+++ N
Sbjct: 362 QVQGMTGNIQFDTYGRRTNYTIDVY-----EMKVSGSRKAGYWNEYERFV-PFSDQQISN 415

Query: 437 NMRGVVLR---VVTVLEEPFVMVSEN--VLGKPKKYQGFSIDVLDALSNYLGFNYEIYVA 491
           +      R   V T+LE P+VM  +N   L   ++Y+G+ +D+   ++ ++   Y++ + 
Sbjct: 416 DSASSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIV 475

Query: 492 PDHKYGSPQ-EDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLR 550
            D KYG+   E   WNG+VGELV+ RADI ++ LTIT  RE V+DF+  +M   + ++++
Sbjct: 476 GDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIK 535

Query: 551 RAEKTVD-MFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNP--------------PRL 595
           + +K+   +F+ L P    +W CI    + V ++++L++  +P              P+ 
Sbjct: 536 KPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQS 595

Query: 596 QMGSMTSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAF 655
                    ++NS+WF  G+F+QQG ++   +L+ R++ G WW F LI+ISSYTANLAAF
Sbjct: 596 PPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAF 655

Query: 656 LTITRIESSIQSLQDLSKQTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWRMINRS 715
           LT+ R+ S I+S +DL+KQTEI YGT+   +  E  R   +      ++Y +MW  +  +
Sbjct: 656 LTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKI------AVYEKMWSYMKSA 709

Query: 716 NGS--ENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTIGNTVADRGYGIA 773
             S       +  A ++K K G +AF+ ++ + EY+    P C    +G  +  +GYG+A
Sbjct: 710 EPSVFTKTTADGVARVRKSK-GKFAFLLESTMNEYIEQRKP-CDTMKVGGNLDSKGYGVA 767

Query: 774 LQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIKSFAG 833
              GS      +  +L+L + G +D LK+KWW   G+C    S  +K K  AL + + AG
Sbjct: 768 TPKGSALGTPVNLAVLKLSEQGILDKLKNKWWYDKGECGAKDS-GSKDKTSALSLSNVAG 826

Query: 834 VFCILAAGIVLSCFIAMLETWWNKRKGSR 862
           VF IL  G+ L+  +A++E  +  R  S+
Sbjct: 827 VFYILVGGLGLAMMVALIEFCYKSRAESK 855


>gi|134304851 glutamate receptor, ionotropic, AMPA 2 isoform 3 [Homo
           sapiens]
          Length = 836

 Score =  339 bits (869), Expect = 9e-93
 Identities = 234/828 (28%), Positives = 405/828 (48%), Gaps = 75/828 (9%)

Query: 62  KITFSVTFVDGNNPFQAVQEACELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQR 121
           ++T  +  ++  N F      C   ++G+ A+       S  ++ S    +H+  +    
Sbjct: 10  RLTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSF 69

Query: 122 STAGTPRSGCGLTRSNRNDDYTLSVRPPVYLHDVILRVVTEYAWQKFIIFYDSEYDIRGI 181
            T GT               + + +RP   L   +L ++  Y W KF   YDS+  +  +
Sbjct: 70  PTDGT-------------HPFVIQMRPD--LKGALLSLIEYYQWDKFAYLYDSDRGLSTL 114

Query: 182 QEFLDKVSQQGMDVALQKVENNIN----KMITTLFDTMRIEELNRYRDTLRRAILVMNPA 237
           Q  LD  +++   V    V N  N    +M  +LF  + +++        RR IL     
Sbjct: 115 QAVLDSAAEKKWQVTAINVGNINNDKKDEMYRSLFQDLELKKE-------RRVILDCERD 167

Query: 238 TAKSFITEVVETNLVAFDCHWIIINEEINDVDVQELV--RRSIGRLTIIRQTFPVPQNIS 295
                + +V+         H+II N    D D+ ++     ++    I+     +     
Sbjct: 168 KVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFI 227

Query: 296 QRCFRGNHRISSTLCDPKDPFAQNMEI--SNLYIYDTVLLLANAFHKKLEDRKWHSMASL 353
           +R         STL + + P A    I  ++   YD V ++  AF    + R   S    
Sbjct: 228 ERW--------STLEEKEYPGAHTTTIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGN 279

Query: 354 S--CIRKNSKPWQGGRSMLETIKKGGVSGLTGELEFGENGGNPNVHFEILGTNYGEELGR 411
           +  C+   + PW  G  +   +K+  V GL+G ++F +NG   N    I+     E    
Sbjct: 280 AGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIM-----ELKTN 334

Query: 412 GVRKLGCWNPVTGLNGSLTDKKLENNMRGV---VLRVVTVLEEPFVMVSEN--VLGKPKK 466
           G RK+G W+ V  +  +LT+    N+  G+    + V T+LE P+VM+ +N  +L   ++
Sbjct: 335 GPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNER 394

Query: 467 YQGFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQEDGT-WNGLVGELVFKRADIGISALT 525
           Y+G+ +D+   ++ + GF Y++ +  D KYG+   D   WNG+VGELV+ +ADI I+ LT
Sbjct: 395 YEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLT 454

Query: 526 ITPDRENVVDFTTRYMDYSVGVLLRRAEKTVD-MFACLAPFDLSLWACIAGTVLLVGLLV 584
           IT  RE V+DF+  +M   + +++++ +K+   +F+ L P    +W CI    + V +++
Sbjct: 455 ITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVL 514

Query: 585 YLLNWLNP-----PRLQMGSMTSTT-------LYNSMWFVYGSFVQQGGEVPYTTLATRM 632
           +L++  +P        + G  T ++       ++NS+WF  G+F++QG ++   +L+ R+
Sbjct: 515 FLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMRQGCDISPRSLSGRI 574

Query: 633 MMGAWWLFALIVISSYTANLAAFLTITRIESSIQSLQDLSKQTEIPYGTVLDSAVYEHVR 692
           + G WW F LI+ISSYTANLAAFLT+ R+ S I+S +DLSKQTEI YGT+   +  E  R
Sbjct: 575 VGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFR 634

Query: 693 MKGLNPFERDSMYSQMWRMINRSNGS--ENNVLESQAGIQKVKYGNYAFVWDAAVLEYVA 750
              +      +++ +MW  +  +  S       E  A ++K K G YA++ ++ + EY+ 
Sbjct: 635 RSKI------AVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSK-GKYAYLLESTMNEYIE 687

Query: 751 INDPDCSFYTIGNTVADRGYGIALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKNGQ 810
              P C    +G  +  +GYGIA   GS  R   +  +L+L + G +D LK+KWW   G+
Sbjct: 688 QRKP-CDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGE 746

Query: 811 CDLYSSVDTKQKGGALDIKSFAGVFCILAAGIVLSCFIAMLETWWNKR 858
           C    S  +K+K  AL + + AGVF IL  G+ L+  +A++E  +  R
Sbjct: 747 CGAKDS-GSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSR 793


>gi|164419736 glutamate receptor, ionotrophic, AMPA 4 isoform 2
           precursor [Homo sapiens]
          Length = 884

 Score =  337 bits (863), Expect = 4e-92
 Identities = 237/867 (27%), Positives = 412/867 (47%), Gaps = 83/867 (9%)

Query: 25  SIIHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQTE-KITFSVTFVDGNNPFQAVQEAC 83
           S + IG +F  +  ++   FR A+   N +    +    +   V  ++  N F      C
Sbjct: 25  SSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHVDNIETANSFAVTNAFC 84

Query: 84  ELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRNDDYT 143
              ++G+ A+       S  +L S   A+HI  +     T   P  G           + 
Sbjct: 85  SQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLI-----TPSFPTEG--------ESQFV 131

Query: 144 LSVRPPVYLHDVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQKVENN 203
           L +RP   L   +L ++  Y W  F+  YD++     +Q  ++K  Q G  V+   VEN 
Sbjct: 132 LQLRPS--LRGALLSLLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVENF 189

Query: 204 INKMITTLFDTMRIEELNRYRDTLRRAILVMNPATAKSFITEVVETNLVAFDCHWIIINE 263
            +     L     +EEL+R ++  ++ ++       ++ + ++V         H+II N 
Sbjct: 190 NDVSYRQL-----LEELDRRQE--KKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANL 242

Query: 264 EINDVDVQELVR--RSIGRLTIIRQTFPVPQNISQRCFRGNHR-ISSTLCDPKDPFAQNM 320
              D+ ++  +    ++    ++    P+   +  R  + + R    +   PK       
Sbjct: 243 GFKDISLERFIHGGANVTGFQLVDFNTPMVIKLMDRWKKLDQREYPGSETPPK------- 295

Query: 321 EISNLYIYDTVLLLANAFHKKLEDRKWHSMASLS--CIRKNSKPWQGGRSMLETIKKGGV 378
             ++   YD VL++A  F      +   S    +  C+   + PW  G  M  T+K+  +
Sbjct: 296 -YTSALTYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVRI 354

Query: 379 SGLTGELEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTGLNGSLTDKKLENNM 438
            GLTG ++F   G   N   ++      E    G RK+G WN +  L        L N+ 
Sbjct: 355 QGLTGNVQFDHYGRRVNYTMDVF-----ELKSTGPRKVGYWNDMDKLVLIQDVPTLGNDT 409

Query: 439 RGVVLRVV---TVLEEPFVMVSEN--VLGKPKKYQGFSIDVLDALSNYLGFNYEIYVAPD 493
             +  R V   T++E P+VM  +N  +     KY+G+ +D+   ++ ++G  Y+I + PD
Sbjct: 410 AAIENRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPD 469

Query: 494 HKYGSPQEDGT-WNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLRRA 552
            KYG+   D   WNG+VGELV+ +A+I I+ LTIT  RE V+DF+  +M   + +++++ 
Sbjct: 470 GKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKP 529

Query: 553 EKTVD-MFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNP------------------P 593
           +K+   +F+ L P    +W CI    + V ++++L++  +P                  P
Sbjct: 530 QKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQP 589

Query: 594 RLQMGSMTSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLA 653
             + G      ++NS+WF  G+F+QQG ++   +L+ R++ G WW F LI+ISSYTANLA
Sbjct: 590 PNEFG------IFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLA 643

Query: 654 AFLTITRIESSIQSLQDLSKQTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWRMIN 713
           AFLT+ R+ S I+S +DL+KQTEI YGT+   +  E  R   +      ++Y +MW  + 
Sbjct: 644 AFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKI------AVYEKMWTYMR 697

Query: 714 RSNGS--ENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTIGNTVADRGYG 771
            +  S       E  A ++K K G +AF+ ++ + EY+    P C    +G  +  +GYG
Sbjct: 698 SAEPSVFTRTTAEGVARVRKSK-GKFAFLLESTMNEYIEQRKP-CDTMKVGGNLDSKGYG 755

Query: 772 IALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIKSF 831
           +A   GS   +  +  +L+L + G +D LK+KWW   G+C      D+K K  AL + + 
Sbjct: 756 VATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECG-SGGGDSKDKTSALSLSNV 814

Query: 832 AGVFCILAAGIVLSCFIAMLETWWNKR 858
           AGVF IL  G+ L+  +A++E  +  R
Sbjct: 815 AGVFYILVGGLGLAMLVALIEFCYKSR 841


>gi|164419734 glutamate receptor, ionotrophic, AMPA 4 isoform 1
           precursor [Homo sapiens]
          Length = 902

 Score =  333 bits (855), Expect = 4e-91
 Identities = 237/867 (27%), Positives = 411/867 (47%), Gaps = 83/867 (9%)

Query: 25  SIIHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQTE-KITFSVTFVDGNNPFQAVQEAC 83
           S + IG +F  +  ++   FR A+   N +    +    +   V  ++  N F      C
Sbjct: 25  SSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHVDNIETANSFAVTNAFC 84

Query: 84  ELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRNDDYT 143
              ++G+ A+       S  +L S   A+HI  +     T   P  G           + 
Sbjct: 85  SQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLI-----TPSFPTEG--------ESQFV 131

Query: 144 LSVRPPVYLHDVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQKVENN 203
           L +RP   L   +L ++  Y W  F+  YD++     +Q  ++K  Q G  V+   VEN 
Sbjct: 132 LQLRPS--LRGALLSLLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVENF 189

Query: 204 INKMITTLFDTMRIEELNRYRDTLRRAILVMNPATAKSFITEVVETNLVAFDCHWIIINE 263
            +     L     +EEL+R ++  ++ ++       ++ + ++V         H+II N 
Sbjct: 190 NDVSYRQL-----LEELDRRQE--KKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANL 242

Query: 264 EINDVDVQELVR--RSIGRLTIIRQTFPVPQNISQRCFRGNHR-ISSTLCDPKDPFAQNM 320
              D+ ++  +    ++    ++    P+   +  R  + + R    +   PK       
Sbjct: 243 GFKDISLERFIHGGANVTGFQLVDFNTPMVIKLMDRWKKLDQREYPGSETPPK------- 295

Query: 321 EISNLYIYDTVLLLANAFHKKLEDRKWHSMASLS--CIRKNSKPWQGGRSMLETIKKGGV 378
             ++   YD VL++A  F      +   S    +  C+   + PW  G  M  T+K+  +
Sbjct: 296 -YTSALTYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVRI 354

Query: 379 SGLTGELEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTGLNGSLTDKKLENNM 438
            GLTG ++F   G   N   ++      E    G RK+G WN +  L        L N+ 
Sbjct: 355 QGLTGNVQFDHYGRRVNYTMDVF-----ELKSTGPRKVGYWNDMDKLVLIQDVPTLGNDT 409

Query: 439 RGVVLRVV---TVLEEPFVMVSEN--VLGKPKKYQGFSIDVLDALSNYLGFNYEIYVAPD 493
             +  R V   T++E P+VM  +N  +     KY+G+ +D+   ++ ++G  Y+I + PD
Sbjct: 410 AAIENRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPD 469

Query: 494 HKYGSPQEDGT-WNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLRRA 552
            KYG+   D   WNG+VGELV+ +A+I I+ LTIT  RE V+DF+  +M   + +++++ 
Sbjct: 470 GKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKP 529

Query: 553 EKTVD-MFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNP------------------P 593
           +K+   +F+ L P    +W CI    + V ++++L++  +P                  P
Sbjct: 530 QKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQP 589

Query: 594 RLQMGSMTSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLA 653
             + G      ++NS+WF  G+F+QQG ++   +L+ R++ G WW F LI+ISSYTANLA
Sbjct: 590 PNEFG------IFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLA 643

Query: 654 AFLTITRIESSIQSLQDLSKQTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWRMIN 713
           AFLT+ R+ S I+S +DL+KQTEI YGT+   +  E  R   +      ++Y +MW  + 
Sbjct: 644 AFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKI------AVYEKMWTYMR 697

Query: 714 RSNGS--ENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTIGNTVADRGYG 771
            +  S       E  A ++K K G +AF+ ++ + EY+    P C    +G  +  +GYG
Sbjct: 698 SAEPSVFTRTTAEGVARVRKSK-GKFAFLLESTMNEYIEQRKP-CDTMKVGGNLDSKGYG 755

Query: 772 IALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIKSF 831
           +A   GS      +  +L+L + G +D LK+KWW   G+C    S  +K K  AL + + 
Sbjct: 756 VATPKGSSLGTPVNLAVLKLSEAGVLDKLKNKWWYDKGECGPKDS-GSKDKTSALSLSNV 814

Query: 832 AGVFCILAAGIVLSCFIAMLETWWNKR 858
           AGVF IL  G+ L+  +A++E  +  R
Sbjct: 815 AGVFYILVGGLGLAMLVALIEFCYKSR 841


>gi|29029595 glutamate receptor KA1 precursor [Homo sapiens]
          Length = 956

 Score =  305 bits (782), Expect = 1e-82
 Identities = 206/659 (31%), Positives = 337/659 (51%), Gaps = 50/659 (7%)

Query: 220 LNRYRDTLRRAILV-MNPATAKSFITEVVETNLVAFDCHWIIINEEINDVDVQELV--RR 276
           L   RD     I++  N + + + + +  E  +V+    +I  N E +   +  LV  R 
Sbjct: 204 LKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQRMDSLVDDRV 263

Query: 277 SIGRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQNMEISNLYIYDTVLLLAN 336
           +I   +I  Q+    Q  +Q      ++     CD   PF     +S+  ++D V  +  
Sbjct: 264 NILGFSIFNQSHAFFQEFAQSL----NQSWQENCDHV-PFT-GPALSSALLFDAVYAVVT 317

Query: 337 AFHKKLEDRKWHSMASLSCIRKNSKPWQGGRSMLETIKKGGVSGLTGELEFGENGGNPNV 396
           A  ++L   +   +  LSC   +++ WQ G S++  ++   + GLTG +EF   G   N 
Sbjct: 318 AV-QELNRSQEIGVKPLSC--GSAQIWQHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNY 374

Query: 397 HFEILGTNYGEELGRGVRKLGCWNPVTGLN--GSLTDKKLENNMRGVVLRVVTVLEEPFV 454
             +IL     +    G R++G W+   GL+    L    + + +    L V T+LE P++
Sbjct: 375 ALKIL-----QFTRNGFRQIGQWHVAEGLSMDSHLYASNISDTLFNTTLVVTTILENPYL 429

Query: 455 MVSEN--VLGKPKKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQEDGTWNGLVGEL 512
           M+  N   +    +Y+GF +D+L  L+  L FNY+I +  D  YG P+ +GTW G+VGEL
Sbjct: 430 MLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANGTWTGMVGEL 489

Query: 513 VFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLR-RAEKTVDMFACLAPFDLSLWA 571
           + ++AD+ ++ LTIT +RE V+DF+  +M   + +L R    +    F+ L PF   +W 
Sbjct: 490 IARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPGVWL 549

Query: 572 CIAGTVLLVGLLVYLL------NWLNPPRLQMGS----MTSTTLYNSMWFVYGSFVQQGG 621
            +    L V  +++L+       W +P     G     +   +L NS+WF  G F+QQG 
Sbjct: 550 FMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGS 609

Query: 622 EVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITRIESSIQSLQDLSKQTEIPYGT 681
            +    L+TR + G WW F LI+ISSYTANLAAFLT+ R++  I+S+ DL+ QT I YGT
Sbjct: 610 TIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQTAIEYGT 669

Query: 682 VLDSAVYEHVRMKGLNPFERDSMYSQMWRMINRSNGSENNVL--ESQAGIQKVKYGNYAF 739
           +   +            F ++S Y    RM N     + +V    ++ GI +V   NYAF
Sbjct: 670 IHGGSSM---------TFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSNYAF 720

Query: 740 VWDAAVLEYVAINDPDCSFYTIGNTVADRGYGIALQHGSPYRDVFSQRILELQQNGDMDI 799
           + ++ + EY      +C+   IG  +  +GYGI +  GS +RD F   IL+LQ+N  ++I
Sbjct: 721 LLESTMNEY--YRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEI 778

Query: 800 LKHKWWPKNGQCDLYSSVDTKQKGGALDIKSFAGVFCILAAGIVLSCFIAMLETWWNKR 858
           LK KWW + G+C      D + KG  L +++  G+F +L  G++++ F+AMLE  W  R
Sbjct: 779 LKRKWW-EGGKCP--KEEDHRAKG--LGMENIGGIFVVLICGLIVAIFMAMLEFLWTLR 832


>gi|29029597 glutamate receptor KA2 precursor [Homo sapiens]
          Length = 980

 Score =  301 bits (772), Expect = 2e-81
 Identities = 184/557 (33%), Positives = 297/557 (53%), Gaps = 41/557 (7%)

Query: 322 ISNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIRKNSKPWQGGRSMLETIKKGGVSGL 381
           +S   ++D V ++ +A  ++L   +   +  L+C   N   W  G S++  ++     GL
Sbjct: 302 LSAALMFDAVHVVVSAV-RELNRSQEIGVKPLACTSANI--WPHGTSLMNYLRMVEYDGL 358

Query: 382 TGELEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCW--NPVTGLNGSLTDKKLENNMR 439
           TG +EF   G   N    IL     E+  +G R++G W  N    +N +  D  L   + 
Sbjct: 359 TGRVEFNSKGQRTNYTLRIL-----EKSRQGHREIGVWYSNRTLAMNATTLDINLSQTLA 413

Query: 440 GVVLRVVTVLEEPFVMVSEN--VLGKPKKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYG 497
              L V T+LE P+VM   N   L   ++++GF +D+L  L+  L F Y + +  D  YG
Sbjct: 414 NKTLVVTTILENPYVMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYG 473

Query: 498 SPQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLR-RAEKTV 556
           +P+ +G+W G+VGEL+ ++AD+ ++A TIT +RE V+DF+  +M   + +L R    +  
Sbjct: 474 APEPNGSWTGMVGELINRKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKP 533

Query: 557 DMFACLAPFDLSLWACIAGTVLLVGLLVYLL------NWLNP-PRLQMGSM---TSTTLY 606
             F+ L PF  ++W  +    L V  +++L        W NP P L+          TL 
Sbjct: 534 GYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLG 593

Query: 607 NSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITRIESSIQ 666
           NS+WF  G F+QQG E+    L+TR + G WW F LI+ISSYTANLAAFLT+ R+E  ++
Sbjct: 594 NSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVE 653

Query: 667 SLQDLSKQTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWRMINRSNGSENNVL--E 724
           S  DL+ QT I YGT+   +            F ++S Y    RM N     + +V    
Sbjct: 654 SADDLADQTNIEYGTIHAGSTM---------TFFQNSRYQTYQRMWNYMQSKQPSVFVKS 704

Query: 725 SQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTIGNTVADRGYGIALQHGSPYRDVF 784
           ++ GI +V    YAF+ ++ + EY      +C+   IG  +  +GYGI +  GSP+RD  
Sbjct: 705 TEEGIARVLNSRYAFLLESTMNEY--HRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEI 762

Query: 785 SQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIKSFAGVFCILAAGIVL 844
           +  IL+LQ+N  ++ILK KWW + G+C      D + KG  L +++  G+F +L  G+++
Sbjct: 763 TLAILQLQENNRLEILKRKWW-EGGRCP--KEEDHRAKG--LGMENIGGIFIVLICGLII 817

Query: 845 SCFIAMLETWWNKRKGS 861
           + F+A++E  W+ R+ +
Sbjct: 818 AVFVAVMEFIWSTRRSA 834


>gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens]
          Length = 885

 Score =  198 bits (503), Expect = 2e-50
 Identities = 220/924 (23%), Positives = 392/924 (42%), Gaps = 153/924 (16%)

Query: 7   LLVLSVWWSRTWDSANAD-SIIHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQTEKITF 65
           LL L++ +S +   A  D  I++IGA+   S +K +++FR AV   N+     + +    
Sbjct: 6   LLTLALLFSCSVARAACDPKIVNIGAVL--STRKHEQMFREAVNQANKRHGSWKIQLNAT 63

Query: 66  SVTFVDGNNPFQAVQEACE-LMNQGILALVSSIGCT-----SAGSLQSLADAMHIPHLFI 119
           SVT     N  Q     CE L++  + A++ S   T     +   +   A    IP L +
Sbjct: 64  SVTHKP--NAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGL 121

Query: 120 QRSTAGTPRSGCGLTRSNRNDDYTLSVRPPVYLHDVILRVVTEYAWQKFIIFYDSEYDIR 179
               +        L+       +  +V P  +   V   ++  Y+W   I+    +++ R
Sbjct: 122 TTRMSIYSDKSIHLS-------FLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGR 174

Query: 180 GIQEFLDKVSQQGMDVALQKVENNINKMITTLFDTMRIEELNRYRDTLRRAILVMNPAT- 238
             Q+ L+ +        L++ E+   K++     T  +  L      L   +++++ +  
Sbjct: 175 AAQKRLETL--------LEERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASED 226

Query: 239 -AKSFITEVVETNLVAFDCHWIIINEEINDVDVQELVRRSIGRLTIIRQTFPVPQNISQR 297
            A +        N+      W++   EI+   ++      +G   I              
Sbjct: 227 DAATVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGILGLQLI-------------- 272

Query: 298 CFRGNHRISSTLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIR 357
                                N +  + +I D V ++A A H+ LE           C+ 
Sbjct: 273 ---------------------NGKNESAHISDAVGVVAQAVHELLEKENITDPPR-GCVG 310

Query: 358 KNSKPWQGGRSMLETIKKGGVS-GLTGELEFGENGGNPNVHFEILGTNYGEELGRGVRKL 416
            N+  W+ G      +     + G+TG +EF E+G     ++ I+         R + ++
Sbjct: 311 -NTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQ-----NRKLVQV 364

Query: 417 GCWNPVTGLN--------GSLTDKKLENNMRGVVLRVVTVLEEPFVMVSEN--------- 459
           G +N    +         G  T+K     M    L++VT+ +EPFV V            
Sbjct: 365 GIYNGTHVIPNDRKIIWPGGETEKPRGYQM-STRLKIVTIHQEPFVYVKPTLSDGTCKEE 423

Query: 460 --VLGKPKKY----------------------QGFSIDVLDALSNYLGFNYEIYVAPDHK 495
             V G P K                        GF ID+L  L+  + F YE+++  D K
Sbjct: 424 FTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGK 483

Query: 496 YGSPQEDGT-----WNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLR 550
           +G+ +         WNG++GEL+  +AD+ ++ LTI  +R   ++F+  +    + +L++
Sbjct: 484 FGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVK 543

Query: 551 R--AEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNP-PRLQMGS----MTST 603
           +     T+D F  + PF  +LW  +  +V +V +++YLL+  +P  R ++ S      + 
Sbjct: 544 KEIPRSTLDSF--MQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDAL 601

Query: 604 TLYNSMWFVYGSFVQQG-GEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITRIE 662
           TL ++MWF +G  +  G GE    + + R++   W  FA+I+++SYTANLAAFL + R E
Sbjct: 602 TLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPE 661

Query: 663 SSIQSLQD---LSKQTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWRMINRSNGSE 719
             I  + D    +   +  Y TV  S+V  + R +     E  +MY  M          +
Sbjct: 662 ERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQ----VELSTMYRHM---------EK 708

Query: 720 NNVLESQAGIQKVKYGN-YAFVWDAAVLEYVAINDPDCSFYTIGNTVADRGYGIALQHGS 778
           +N   +   IQ V+    +AF+WD+AVLE+ A     C   T G      G+GI ++  S
Sbjct: 709 HNYESAAEAIQAVRDNKLHAFIWDSAVLEFEA--SQKCDLVTTGELFFRSGFGIGMRKDS 766

Query: 779 PYRDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIKSFAGVFCIL 838
           P++   S  IL+  +NG M+ L  K W +  +CD  S+         L  ++ AGVF ++
Sbjct: 767 PWKQNVSLSILKSHENGFMEDL-DKTWVRYQECDSRSNAP-----ATLTFENMAGVFMLV 820

Query: 839 AAGIVLSCFIAMLETWWNKRKGSR 862
           A GIV   F+  +E  + + K +R
Sbjct: 821 AGGIVAGIFLIFIEIAYKRHKDAR 844


>gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens]
          Length = 938

 Score =  198 bits (503), Expect = 2e-50
 Identities = 220/924 (23%), Positives = 392/924 (42%), Gaps = 153/924 (16%)

Query: 7   LLVLSVWWSRTWDSANAD-SIIHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQTEKITF 65
           LL L++ +S +   A  D  I++IGA+   S +K +++FR AV   N+     + +    
Sbjct: 6   LLTLALLFSCSVARAACDPKIVNIGAVL--STRKHEQMFREAVNQANKRHGSWKIQLNAT 63

Query: 66  SVTFVDGNNPFQAVQEACE-LMNQGILALVSSIGCT-----SAGSLQSLADAMHIPHLFI 119
           SVT     N  Q     CE L++  + A++ S   T     +   +   A    IP L +
Sbjct: 64  SVTHKP--NAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGL 121

Query: 120 QRSTAGTPRSGCGLTRSNRNDDYTLSVRPPVYLHDVILRVVTEYAWQKFIIFYDSEYDIR 179
               +        L+       +  +V P  +   V   ++  Y+W   I+    +++ R
Sbjct: 122 TTRMSIYSDKSIHLS-------FLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGR 174

Query: 180 GIQEFLDKVSQQGMDVALQKVENNINKMITTLFDTMRIEELNRYRDTLRRAILVMNPAT- 238
             Q+ L+ +        L++ E+   K++     T  +  L      L   +++++ +  
Sbjct: 175 AAQKRLETL--------LEERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASED 226

Query: 239 -AKSFITEVVETNLVAFDCHWIIINEEINDVDVQELVRRSIGRLTIIRQTFPVPQNISQR 297
            A +        N+      W++   EI+   ++      +G   I              
Sbjct: 227 DAATVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGILGLQLI-------------- 272

Query: 298 CFRGNHRISSTLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIR 357
                                N +  + +I D V ++A A H+ LE           C+ 
Sbjct: 273 ---------------------NGKNESAHISDAVGVVAQAVHELLEKENITDPPR-GCVG 310

Query: 358 KNSKPWQGGRSMLETIKKGGVS-GLTGELEFGENGGNPNVHFEILGTNYGEELGRGVRKL 416
            N+  W+ G      +     + G+TG +EF E+G     ++ I+         R + ++
Sbjct: 311 -NTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQ-----NRKLVQV 364

Query: 417 GCWNPVTGLN--------GSLTDKKLENNMRGVVLRVVTVLEEPFVMVSEN--------- 459
           G +N    +         G  T+K     M    L++VT+ +EPFV V            
Sbjct: 365 GIYNGTHVIPNDRKIIWPGGETEKPRGYQM-STRLKIVTIHQEPFVYVKPTLSDGTCKEE 423

Query: 460 --VLGKPKKY----------------------QGFSIDVLDALSNYLGFNYEIYVAPDHK 495
             V G P K                        GF ID+L  L+  + F YE+++  D K
Sbjct: 424 FTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGK 483

Query: 496 YGSPQEDGT-----WNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLR 550
           +G+ +         WNG++GEL+  +AD+ ++ LTI  +R   ++F+  +    + +L++
Sbjct: 484 FGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVK 543

Query: 551 R--AEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNP-PRLQMGS----MTST 603
           +     T+D F  + PF  +LW  +  +V +V +++YLL+  +P  R ++ S      + 
Sbjct: 544 KEIPRSTLDSF--MQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDAL 601

Query: 604 TLYNSMWFVYGSFVQQG-GEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITRIE 662
           TL ++MWF +G  +  G GE    + + R++   W  FA+I+++SYTANLAAFL + R E
Sbjct: 602 TLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPE 661

Query: 663 SSIQSLQD---LSKQTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWRMINRSNGSE 719
             I  + D    +   +  Y TV  S+V  + R +     E  +MY  M          +
Sbjct: 662 ERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQ----VELSTMYRHM---------EK 708

Query: 720 NNVLESQAGIQKVKYGN-YAFVWDAAVLEYVAINDPDCSFYTIGNTVADRGYGIALQHGS 778
           +N   +   IQ V+    +AF+WD+AVLE+ A     C   T G      G+GI ++  S
Sbjct: 709 HNYESAAEAIQAVRDNKLHAFIWDSAVLEFEA--SQKCDLVTTGELFFRSGFGIGMRKDS 766

Query: 779 PYRDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIKSFAGVFCIL 838
           P++   S  IL+  +NG M+ L  K W +  +CD  S+         L  ++ AGVF ++
Sbjct: 767 PWKQNVSLSILKSHENGFMEDL-DKTWVRYQECDSRSNAP-----ATLTFENMAGVFMLV 820

Query: 839 AAGIVLSCFIAMLETWWNKRKGSR 862
           A GIV   F+  +E  + + K +R
Sbjct: 821 AGGIVAGIFLIFIEIAYKRHKDAR 844


>gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens]
          Length = 901

 Score =  198 bits (503), Expect = 2e-50
 Identities = 220/924 (23%), Positives = 392/924 (42%), Gaps = 153/924 (16%)

Query: 7   LLVLSVWWSRTWDSANAD-SIIHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQTEKITF 65
           LL L++ +S +   A  D  I++IGA+   S +K +++FR AV   N+     + +    
Sbjct: 6   LLTLALLFSCSVARAACDPKIVNIGAVL--STRKHEQMFREAVNQANKRHGSWKIQLNAT 63

Query: 66  SVTFVDGNNPFQAVQEACE-LMNQGILALVSSIGCT-----SAGSLQSLADAMHIPHLFI 119
           SVT     N  Q     CE L++  + A++ S   T     +   +   A    IP L +
Sbjct: 64  SVTHKP--NAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGL 121

Query: 120 QRSTAGTPRSGCGLTRSNRNDDYTLSVRPPVYLHDVILRVVTEYAWQKFIIFYDSEYDIR 179
               +        L+       +  +V P  +   V   ++  Y+W   I+    +++ R
Sbjct: 122 TTRMSIYSDKSIHLS-------FLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGR 174

Query: 180 GIQEFLDKVSQQGMDVALQKVENNINKMITTLFDTMRIEELNRYRDTLRRAILVMNPAT- 238
             Q+ L+ +        L++ E+   K++     T  +  L      L   +++++ +  
Sbjct: 175 AAQKRLETL--------LEERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASED 226

Query: 239 -AKSFITEVVETNLVAFDCHWIIINEEINDVDVQELVRRSIGRLTIIRQTFPVPQNISQR 297
            A +        N+      W++   EI+   ++      +G   I              
Sbjct: 227 DAATVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGILGLQLI-------------- 272

Query: 298 CFRGNHRISSTLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIR 357
                                N +  + +I D V ++A A H+ LE           C+ 
Sbjct: 273 ---------------------NGKNESAHISDAVGVVAQAVHELLEKENITDPPR-GCVG 310

Query: 358 KNSKPWQGGRSMLETIKKGGVS-GLTGELEFGENGGNPNVHFEILGTNYGEELGRGVRKL 416
            N+  W+ G      +     + G+TG +EF E+G     ++ I+         R + ++
Sbjct: 311 -NTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQ-----NRKLVQV 364

Query: 417 GCWNPVTGLN--------GSLTDKKLENNMRGVVLRVVTVLEEPFVMVSEN--------- 459
           G +N    +         G  T+K     M    L++VT+ +EPFV V            
Sbjct: 365 GIYNGTHVIPNDRKIIWPGGETEKPRGYQM-STRLKIVTIHQEPFVYVKPTLSDGTCKEE 423

Query: 460 --VLGKPKKY----------------------QGFSIDVLDALSNYLGFNYEIYVAPDHK 495
             V G P K                        GF ID+L  L+  + F YE+++  D K
Sbjct: 424 FTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGK 483

Query: 496 YGSPQEDGT-----WNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLR 550
           +G+ +         WNG++GEL+  +AD+ ++ LTI  +R   ++F+  +    + +L++
Sbjct: 484 FGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVK 543

Query: 551 R--AEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNP-PRLQMGS----MTST 603
           +     T+D F  + PF  +LW  +  +V +V +++YLL+  +P  R ++ S      + 
Sbjct: 544 KEIPRSTLDSF--MQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDAL 601

Query: 604 TLYNSMWFVYGSFVQQG-GEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITRIE 662
           TL ++MWF +G  +  G GE    + + R++   W  FA+I+++SYTANLAAFL + R E
Sbjct: 602 TLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPE 661

Query: 663 SSIQSLQD---LSKQTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWRMINRSNGSE 719
             I  + D    +   +  Y TV  S+V  + R +     E  +MY  M          +
Sbjct: 662 ERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQ----VELSTMYRHM---------EK 708

Query: 720 NNVLESQAGIQKVKYGN-YAFVWDAAVLEYVAINDPDCSFYTIGNTVADRGYGIALQHGS 778
           +N   +   IQ V+    +AF+WD+AVLE+ A     C   T G      G+GI ++  S
Sbjct: 709 HNYESAAEAIQAVRDNKLHAFIWDSAVLEFEA--SQKCDLVTTGELFFRSGFGIGMRKDS 766

Query: 779 PYRDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIKSFAGVFCIL 838
           P++   S  IL+  +NG M+ L  K W +  +CD  S+         L  ++ AGVF ++
Sbjct: 767 PWKQNVSLSILKSHENGFMEDL-DKTWVRYQECDSRSNAP-----ATLTFENMAGVFMLV 820

Query: 839 AAGIVLSCFIAMLETWWNKRKGSR 862
           A GIV   F+  +E  + + K +R
Sbjct: 821 AGGIVAGIFLIFIEIAYKRHKDAR 844


>gi|197313638 N-methyl-D-aspartate receptor subunit 2A isoform 2
           precursor [Homo sapiens]
          Length = 1281

 Score =  173 bits (439), Expect = 6e-43
 Identities = 187/758 (24%), Positives = 320/758 (42%), Gaps = 122/758 (16%)

Query: 155 VILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQKVENNINKMITTLFDT 214
           V+L+++ +Y W  F +         G +EF+  V     +  +     N+  + T+  D 
Sbjct: 157 VMLKIMQDYDWHVFSLVTTI---FPGYREFISFVKTTVDNSFVGWDMQNVITLDTSFEDA 213

Query: 215 MRIEELNRYRDTLRRAILVMNPATAKSFITEVVETNLVAFDCHWIIINEEINDVDVQELV 274
               +L +   ++   +L  +   A   ++E     L  +D  WI          V  LV
Sbjct: 214 KTQVQLKKIHSSV--ILLYCSKDEAVLILSEARSLGLTGYDFFWI----------VPSLV 261

Query: 275 RRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQNMEISNLYIYDTVLLL 334
               G   +I + FP                S  +    D +  ++E     + D + +L
Sbjct: 262 S---GNTELIPKEFP----------------SGLISVSYDDWDYSLEAR---VRDGIGIL 299

Query: 335 ANAFHKKLEDRKWHSMASLSCIRKNSKPWQGGRSMLETIKKGGVSGLTGELEFGENGGNP 394
             A    LE   +   A  SC  +  +P     ++   +      G   +L F E G   
Sbjct: 300 TTAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGK--DLSFTEEGYQV 357

Query: 395 NVHFEILGTNYGEELGRGVRKLGCW--------NPVTGLNGSLTDKKLENNMRGVVLRVV 446
           +    ++  N   E      K+G W        + V     S +D + ++N     L +V
Sbjct: 358 HPRLVVIVLNKDREW----EKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNH----LSIV 409

Query: 447 TVLEEPFVMVSE--------------------------NVLGKPKKYQGFSIDVLDALSN 480
           T+ E PFV+V +                            +   K  +GF ID+L  LS 
Sbjct: 410 TLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSR 469

Query: 481 YLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRY 540
            + F Y++Y+  + K+G  + +  WNG++GE+V++RA + + +LTI  +R  VVDF+  +
Sbjct: 470 TVKFTYDLYLVTNGKHGK-KVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPF 528

Query: 541 MDYSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLV-GLLVYLLNWLNP----PRL 595
           ++  + V++ R+  TV   A L PF  S+W  +   +L+V  + V++  + +P      L
Sbjct: 529 VETGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNL 588

Query: 596 QMGSM---TSTTLYNSMWFVYGSFVQQGGEV--PYTTLATRMMMGAWWLFALIVISSYTA 650
             G      S T+  ++W ++G        V  P  T  +++M+  W  FA+I ++SYTA
Sbjct: 589 AKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGT-TSKIMVSVWAFFAVIFLASYTA 647

Query: 651 NLAAFLTITRIESSIQSLQDLSKQTEIPY------GTVLDSAVYEHVRMKGLNPFERDSM 704
           NLAAF+        +  L D   Q    Y      GTV + +   ++R          + 
Sbjct: 648 NLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIR----------NN 697

Query: 705 YSQMWRMINRSNGSENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTIGN- 763
           Y  M + + + N  +  V ++   ++  K    AF++DAAVL Y A  D  C   TIG+ 
Sbjct: 698 YPYMHQYMTKFN--QKGVEDALVSLKTGKLD--AFIYDAAVLNYKAGRDEGCKLVTIGSG 753

Query: 764 -TVADRGYGIALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQK 822
              A  GYGIALQ GSP++      +L+   +G+M+ L+  W    G C    +   +  
Sbjct: 754 YIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLW--LTGIC---HNEKNEVM 808

Query: 823 GGALDIKSFAGVFCILAAGIVLSCFIAMLE--TWWNKR 858
              LDI + AGVF +LAA + LS    + E   +W  R
Sbjct: 809 SSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYWKLR 846


>gi|197313636 N-methyl-D-aspartate receptor subunit 2A isoform 1
           precursor [Homo sapiens]
          Length = 1464

 Score =  173 bits (439), Expect = 6e-43
 Identities = 187/758 (24%), Positives = 320/758 (42%), Gaps = 122/758 (16%)

Query: 155 VILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQKVENNINKMITTLFDT 214
           V+L+++ +Y W  F +         G +EF+  V     +  +     N+  + T+  D 
Sbjct: 157 VMLKIMQDYDWHVFSLVTTI---FPGYREFISFVKTTVDNSFVGWDMQNVITLDTSFEDA 213

Query: 215 MRIEELNRYRDTLRRAILVMNPATAKSFITEVVETNLVAFDCHWIIINEEINDVDVQELV 274
               +L +   ++   +L  +   A   ++E     L  +D  WI          V  LV
Sbjct: 214 KTQVQLKKIHSSV--ILLYCSKDEAVLILSEARSLGLTGYDFFWI----------VPSLV 261

Query: 275 RRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQNMEISNLYIYDTVLLL 334
               G   +I + FP                S  +    D +  ++E     + D + +L
Sbjct: 262 S---GNTELIPKEFP----------------SGLISVSYDDWDYSLEAR---VRDGIGIL 299

Query: 335 ANAFHKKLEDRKWHSMASLSCIRKNSKPWQGGRSMLETIKKGGVSGLTGELEFGENGGNP 394
             A    LE   +   A  SC  +  +P     ++   +      G   +L F E G   
Sbjct: 300 TTAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGK--DLSFTEEGYQV 357

Query: 395 NVHFEILGTNYGEELGRGVRKLGCW--------NPVTGLNGSLTDKKLENNMRGVVLRVV 446
           +    ++  N   E      K+G W        + V     S +D + ++N     L +V
Sbjct: 358 HPRLVVIVLNKDREW----EKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNH----LSIV 409

Query: 447 TVLEEPFVMVSE--------------------------NVLGKPKKYQGFSIDVLDALSN 480
           T+ E PFV+V +                            +   K  +GF ID+L  LS 
Sbjct: 410 TLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSR 469

Query: 481 YLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRY 540
            + F Y++Y+  + K+G  + +  WNG++GE+V++RA + + +LTI  +R  VVDF+  +
Sbjct: 470 TVKFTYDLYLVTNGKHGK-KVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPF 528

Query: 541 MDYSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLV-GLLVYLLNWLNP----PRL 595
           ++  + V++ R+  TV   A L PF  S+W  +   +L+V  + V++  + +P      L
Sbjct: 529 VETGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNL 588

Query: 596 QMGSM---TSTTLYNSMWFVYGSFVQQGGEV--PYTTLATRMMMGAWWLFALIVISSYTA 650
             G      S T+  ++W ++G        V  P  T  +++M+  W  FA+I ++SYTA
Sbjct: 589 AKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGT-TSKIMVSVWAFFAVIFLASYTA 647

Query: 651 NLAAFLTITRIESSIQSLQDLSKQTEIPY------GTVLDSAVYEHVRMKGLNPFERDSM 704
           NLAAF+        +  L D   Q    Y      GTV + +   ++R          + 
Sbjct: 648 NLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIR----------NN 697

Query: 705 YSQMWRMINRSNGSENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTIGN- 763
           Y  M + + + N  +  V ++   ++  K    AF++DAAVL Y A  D  C   TIG+ 
Sbjct: 698 YPYMHQYMTKFN--QKGVEDALVSLKTGKLD--AFIYDAAVLNYKAGRDEGCKLVTIGSG 753

Query: 764 -TVADRGYGIALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQK 822
              A  GYGIALQ GSP++      +L+   +G+M+ L+  W    G C    +   +  
Sbjct: 754 YIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLW--LTGIC---HNEKNEVM 808

Query: 823 GGALDIKSFAGVFCILAAGIVLSCFIAMLE--TWWNKR 858
              LDI + AGVF +LAA + LS    + E   +W  R
Sbjct: 809 SSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYWKLR 846


>gi|4504125 N-methyl-D-aspartate receptor subunit 2A isoform 1
           precursor [Homo sapiens]
          Length = 1464

 Score =  173 bits (439), Expect = 6e-43
 Identities = 187/758 (24%), Positives = 320/758 (42%), Gaps = 122/758 (16%)

Query: 155 VILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQKVENNINKMITTLFDT 214
           V+L+++ +Y W  F +         G +EF+  V     +  +     N+  + T+  D 
Sbjct: 157 VMLKIMQDYDWHVFSLVTTI---FPGYREFISFVKTTVDNSFVGWDMQNVITLDTSFEDA 213

Query: 215 MRIEELNRYRDTLRRAILVMNPATAKSFITEVVETNLVAFDCHWIIINEEINDVDVQELV 274
               +L +   ++   +L  +   A   ++E     L  +D  WI          V  LV
Sbjct: 214 KTQVQLKKIHSSV--ILLYCSKDEAVLILSEARSLGLTGYDFFWI----------VPSLV 261

Query: 275 RRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQNMEISNLYIYDTVLLL 334
               G   +I + FP                S  +    D +  ++E     + D + +L
Sbjct: 262 S---GNTELIPKEFP----------------SGLISVSYDDWDYSLEAR---VRDGIGIL 299

Query: 335 ANAFHKKLEDRKWHSMASLSCIRKNSKPWQGGRSMLETIKKGGVSGLTGELEFGENGGNP 394
             A    LE   +   A  SC  +  +P     ++   +      G   +L F E G   
Sbjct: 300 TTAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGK--DLSFTEEGYQV 357

Query: 395 NVHFEILGTNYGEELGRGVRKLGCW--------NPVTGLNGSLTDKKLENNMRGVVLRVV 446
           +    ++  N   E      K+G W        + V     S +D + ++N     L +V
Sbjct: 358 HPRLVVIVLNKDREW----EKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNH----LSIV 409

Query: 447 TVLEEPFVMVSE--------------------------NVLGKPKKYQGFSIDVLDALSN 480
           T+ E PFV+V +                            +   K  +GF ID+L  LS 
Sbjct: 410 TLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSR 469

Query: 481 YLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRY 540
            + F Y++Y+  + K+G  + +  WNG++GE+V++RA + + +LTI  +R  VVDF+  +
Sbjct: 470 TVKFTYDLYLVTNGKHGK-KVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPF 528

Query: 541 MDYSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLV-GLLVYLLNWLNP----PRL 595
           ++  + V++ R+  TV   A L PF  S+W  +   +L+V  + V++  + +P      L
Sbjct: 529 VETGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNL 588

Query: 596 QMGSM---TSTTLYNSMWFVYGSFVQQGGEV--PYTTLATRMMMGAWWLFALIVISSYTA 650
             G      S T+  ++W ++G        V  P  T  +++M+  W  FA+I ++SYTA
Sbjct: 589 AKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGT-TSKIMVSVWAFFAVIFLASYTA 647

Query: 651 NLAAFLTITRIESSIQSLQDLSKQTEIPY------GTVLDSAVYEHVRMKGLNPFERDSM 704
           NLAAF+        +  L D   Q    Y      GTV + +   ++R          + 
Sbjct: 648 NLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIR----------NN 697

Query: 705 YSQMWRMINRSNGSENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTIGN- 763
           Y  M + + + N  +  V ++   ++  K    AF++DAAVL Y A  D  C   TIG+ 
Sbjct: 698 YPYMHQYMTKFN--QKGVEDALVSLKTGKLD--AFIYDAAVLNYKAGRDEGCKLVTIGSG 753

Query: 764 -TVADRGYGIALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQK 822
              A  GYGIALQ GSP++      +L+   +G+M+ L+  W    G C    +   +  
Sbjct: 754 YIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLW--LTGIC---HNEKNEVM 808

Query: 823 GGALDIKSFAGVFCILAAGIVLSCFIAMLE--TWWNKR 858
              LDI + AGVF +LAA + LS    + E   +W  R
Sbjct: 809 SSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYWKLR 846


>gi|153946391 N-methyl-D-aspartate receptor subunit 2D precursor
           [Homo sapiens]
          Length = 1336

 Score =  167 bits (424), Expect = 4e-41
 Identities = 120/411 (29%), Positives = 207/411 (50%), Gaps = 41/411 (9%)

Query: 468 QGFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTIT 527
           +GF ID+L  L++ +GF+Y++Y+  + K+G  + DG WNG++GE+ ++RAD+ I +LTI 
Sbjct: 485 KGFCIDILKRLAHTIGFSYDLYLVTNGKHGK-KIDGVWNGMIGEVFYQRADMAIGSLTIN 543

Query: 528 PDRENVVDFTTRYMDYSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVL-LVGLLVYL 586
            +R  +VDF+  +++  + V++ R+  TV   A L P+  ++W  +    L +V + V++
Sbjct: 544 EERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFI 603

Query: 587 LNWLNPPRLQMGSMT-------STTLYNSMWFVYGSFVQQGGEV--PYTTLATRMMMGAW 637
             +L+P        T       + T+  S+W ++         V  P  T  +++M+  W
Sbjct: 604 FEYLSPVGYNRSLATGKRPGGSTFTIGKSIWLLWALVFNNSVPVENPRGT-TSKIMVLVW 662

Query: 638 WLFALIVISSYTANLAAFLTITRIESSIQSLQDLSKQ------TEIPYGTVLDSAVYEHV 691
             FA+I ++SYTANLAAF+       ++  L D   Q        + +GTV + +  +++
Sbjct: 663 AFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNI 722

Query: 692 RMKGLNPFERDSMYSQMWRMINRSNGSENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAI 751
           R          S Y  M   + R N  +  V E+   ++  K    AF++DAAVL Y+A 
Sbjct: 723 R----------SNYPDMHSYMVRYN--QPRVEEALTQLKAGKLD--AFIYDAAVLNYMAR 768

Query: 752 NDPDCSFYTIGN--TVADRGYGIALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKNG 809
            D  C   TIG+    A  GYGIAL  GS ++      +L+   + ++++L+  W     
Sbjct: 769 KDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGIC 828

Query: 810 QCDLYSSVDTKQKGGALDIKSFAGVFCILAAGIVLSCFIAMLE--TWWNKR 858
             D    + +K     LDI + AGVF +L   + LS  +   E   +W  R
Sbjct: 829 HNDKIEVMSSK-----LDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLR 874


>gi|167003331 N-methyl-D-aspartate receptor subunit 2B precursor
           [Homo sapiens]
          Length = 1484

 Score =  166 bits (421), Expect = 8e-41
 Identities = 131/457 (28%), Positives = 218/457 (47%), Gaps = 70/457 (15%)

Query: 443 LRVVTVLEEPFVMV----------------------SENVLGKPKKY-----QGFSIDVL 475
           L +VT+ E PFV+V                      +EN   +   Y     +GF ID+L
Sbjct: 406 LSIVTLEEAPFVIVESVDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDIL 465

Query: 476 DALSNYLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITPDRENVVD 535
             +S  + F Y++Y+  + K+G  + +GTWNG++GE+V KRA + + +LTI  +R  VVD
Sbjct: 466 KKISKSVKFTYDLYLVTNGKHGK-KINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVD 524

Query: 536 FTTRYMDYSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLV-GLLVYLLNWLNPPR 594
           F+  +++  + V++ R+  TV   A L PF   +W  +   +L+V  + V++  + +P  
Sbjct: 525 FSVPFIETGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVG 584

Query: 595 L-------QMGSMTSTTLYNSMWFVYGSFVQQGGEV--PYTTLATRMMMGAWWLFALIVI 645
                   +     S T+  ++W ++G        V  P  T  +++M+  W  FA+I +
Sbjct: 585 YNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGT-TSKIMVSVWAFFAVIFL 643

Query: 646 SSYTANLAAFLTITRIESSIQSLQDLSKQ------TEIPYGTVLDSAVYEHVRMKGLNPF 699
           +SYTANLAAF+        +  L D   Q          +GTV + +   ++R       
Sbjct: 644 ASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIR------- 696

Query: 700 ERDSMYSQMWRMINRSN--GSENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCS 757
              + Y++M   + + N  G ++ +L  + G         AF++DAAVL Y+A  D  C 
Sbjct: 697 ---NNYAEMHAYMGKFNQRGVDDALLSLKTGKLD------AFIYDAAVLNYMAGRDEGCK 747

Query: 758 FYTIGN--TVADRGYGIALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYS 815
             TIG+    A  GYGIA+Q  S ++      IL+L  +G+M+ L+  W    G C    
Sbjct: 748 LVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALW--LTGIC---H 802

Query: 816 SVDTKQKGGALDIKSFAGVFCILAAGIVLSCFIAMLE 852
           +   +     LDI + AGVF +L A + LS    + E
Sbjct: 803 NEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICE 839


>gi|55770854 N-methyl-D-aspartate receptor subunit 2C precursor
           [Homo sapiens]
          Length = 1233

 Score =  159 bits (401), Expect = 2e-38
 Identities = 120/412 (29%), Positives = 205/412 (49%), Gaps = 43/412 (10%)

Query: 468 QGFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTIT 527
           +GF ID+L  L+  + F+Y++Y+  + K+G  +  G WNG++GE+ +KRAD+ I +LTI 
Sbjct: 455 KGFCIDILKKLARVVKFSYDLYLVTNGKHGK-RVRGVWNGMIGEVYYKRADMAIGSLTIN 513

Query: 528 PDRENVVDFTTRYMDYSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVL-LVGLLVYL 586
            +R  +VDF+  +++  + V++ R+  TV   A L P+  ++W  +    L +V + V++
Sbjct: 514 EERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFM 573

Query: 587 LNWLNP-------PRLQMGSMTSTTLYNSMWFVYGSFVQQGG--EVPYTTLATRMMMGAW 637
             + +P        R +     + T+  S+W ++          E P  T  +++M+  W
Sbjct: 574 FEYFSPVSYNQNLTRGKKSGGPAFTIGKSVWLLWALVFNNSVPIENPRGT-TSKIMVLVW 632

Query: 638 WLFALIVISSYTANLAAFLTITRIESSIQSLQDLS---KQTEIP---YGTVLDSAVYEHV 691
             FA+I ++SYTANLAAF+   +   ++  L D      Q + P   +GTV + +   ++
Sbjct: 633 AFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNI 692

Query: 692 RMKGLNPFERDSMYSQMWRMINRSNGSENNVLESQAGIQKVKYGNY-AFVWDAAVLEYVA 750
           R        RD M++ M +   RS          +  +  +K G   AF++DAAVL Y+A
Sbjct: 693 RSN-----YRD-MHTHMVKFNQRS---------VEDALTSLKMGKLDAFIYDAAVLNYMA 737

Query: 751 INDPDCSFYTIGN--TVADRGYGIALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKN 808
             D  C   TIG+    A  GYGIA+Q  S ++      +L+   +G+   L+  W   +
Sbjct: 738 GKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVW--LS 795

Query: 809 GQCDLYSSVDTKQKGGALDIKSFAGVFCIL--AAGIVLSCFIAMLETWWNKR 858
           G C    +   +     LDI + AGVF +L  A G+ L  F      +W  R
Sbjct: 796 GIC---QNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVYWKLR 844


>gi|223278356 glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
            [Homo sapiens]
          Length = 1115

 Score =  149 bits (376), Expect = 1e-35
 Identities = 114/447 (25%), Positives = 207/447 (46%), Gaps = 37/447 (8%)

Query: 469  GFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITP 528
            G+ ID+L+ ++  + F++++Y+  D KYG+  ++G W GLVG+L+   A + +++ +I  
Sbjct: 578  GYCIDLLEKIAEDMNFDFDLYIVGDGKYGA-WKNGHWTGLVGDLLRGTAHMAVTSFSINT 636

Query: 529  DRENVVDFTTRYMDYSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLLN 588
             R  V+DFT+ +   S+G+L+R  +    + A + P   ++W  I   + +  + + L  
Sbjct: 637  ARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAVFLTLYE 696

Query: 589  WLNPPRLQMGSMTSTTLYNSMWFVYGSFVQQGGEV----PYTTLATRMMMGAWWLFALIV 644
            W +P  L       + +++    +   +    G      P      R +M  W +F +  
Sbjct: 697  WKSPFGLTPKGRNRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMFC 756

Query: 645  ISSYTANLAAFLTITRIESSIQSLQDLS---KQTEIPYGTVLDSAVYEHVRMKGLNPFER 701
            +S+YTANLAA +   +I   +  + D           +GTV +S+  ++VR         
Sbjct: 757  LSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQS------- 809

Query: 702  DSMYSQMWRMINRSNGSENNVLESQAGIQKVKYGNY---AFVWDAAVLEYVAINDPDCSF 758
               + +M   + R      NV  +  G++ +K       AF+ D A+L+Y    D DC  
Sbjct: 810  ---FPEMHEYMRR-----YNVPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDADCKL 861

Query: 759  YTIGNTVADRGYGIALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKNGQCD--LYSS 816
             T+G   A  GYGI L   SP     S+ I + + +G MD+L  KW+ +   C    ++ 
Sbjct: 862  LTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDKWY-RVVPCGKRSFAV 920

Query: 817  VDTKQKGGALDIKSFAGVFCILAAGIVLSCFIAMLETWWNKRKGSRVPSKEDDKE--IDL 874
             +T Q G    IK F+G+F +L  G  LS    + E    +    R+ +K   +      
Sbjct: 921  TETLQMG----IKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLPRIKNKSKLQYWLHTS 976

Query: 875  EHLHRRVNSLCTDDDSPHKQFSTSSID 901
            + LHR +N+   ++   H  F T  ++
Sbjct: 977  QRLHRAINTSFIEEKQQH--FKTKRVE 1001


>gi|62988346 glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
           [Homo sapiens]
          Length = 1043

 Score =  147 bits (370), Expect = 6e-35
 Identities = 111/410 (27%), Positives = 197/410 (48%), Gaps = 33/410 (8%)

Query: 469 GFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITP 528
           G+ ID+L+ L+    F++E+Y+  D KYG+ + DG W GLVG+L+  RA + +++ +I  
Sbjct: 478 GYCIDLLERLAEDTPFDFELYLVGDGKYGALR-DGRWTGLVGDLLAGRAHMAVTSFSINS 536

Query: 529 DRENVVDFTTRYMDYSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLLN 588
            R  VVDFT+ +   S+G+++R  +    + A + P   S W  +   + L  L + +  
Sbjct: 537 ARSQVVDFTSPFFSTSLGIMVRARDTASPIGAFMWPLHWSTWLGVFAALHLTALFLTVYE 596

Query: 589 WLNPPRLQMGSMTSTTLY---NSMWFVYGSFVQQGGEVPYTTLAT-RMMMGAWWLFALIV 644
           W +P  L       +T++   +++   Y    ++          T R++M  W +F L+V
Sbjct: 597 WRSPYGLTPRGRNRSTVFSYSSALNLCYAILFRRTVSSKTPKCPTGRLLMNLWAIFCLLV 656

Query: 645 ISSYTANLAAFLTITRIESSIQSLQDLS---KQTEIPYGTVLDSAVYEHVRMKGLNPFER 701
           +SSYTANLAA +   +    +  + D           +GTV +S+   +++         
Sbjct: 657 LSSYTANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWESSAEAYIKK------SF 710

Query: 702 DSMYSQMWRMINRSNGSENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTI 761
             M++ M R  + +  +   V    +   K+     AF+ D ++L+Y    D DC   T+
Sbjct: 711 PDMHAHMRR--HSAPTTPRGVAMLTSDPPKLN----AFIMDKSLLDYEVSIDADCKLLTV 764

Query: 762 GNTVADRGYGIALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKNGQCD--LYSSVDT 819
           G   A  GYGI L   SP     S+ I   + +G +D+L  KW+ K   C   +++  +T
Sbjct: 765 GKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWY-KMVPCGKRVFAVTET 823

Query: 820 KQKGGALDIKSFAGVFCILAAGIVLSCFIAMLETWWNK------RKGSRV 863
            Q    + I  FAG+F +L  G+  +   ++ E  + +      RKGSR+
Sbjct: 824 LQ----MSIYHFAGLFVLLCLGLGSALLSSLGEHAFFRLALPRIRKGSRL 869


>gi|116284390 glutamate receptor, ionotrophic, AMPA 4 isoform 3
           precursor [Homo sapiens]
          Length = 433

 Score = 84.7 bits (208), Expect = 4e-16
 Identities = 91/432 (21%), Positives = 171/432 (39%), Gaps = 45/432 (10%)

Query: 25  SIIHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQTE-KITFSVTFVDGNNPFQAVQEAC 83
           S + IG +F  +  ++   FR A+   N +    +    +   V  ++  N F      C
Sbjct: 25  SSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHVDNIETANSFAVTNAFC 84

Query: 84  ELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRNDDYT 143
              ++G+ A+       S  +L S   A+HI  +     T   P  G           + 
Sbjct: 85  SQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLI-----TPSFPTEG--------ESQFV 131

Query: 144 LSVRPPVYLHDVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQKVENN 203
           L +RP   L   +L ++  Y W  F+  YD++     +Q  ++K  Q G  V+   VEN 
Sbjct: 132 LQLRPS--LRGALLSLLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVENF 189

Query: 204 INKMITTLFDTMRIEELNRYRDTLRRAILVMNPATAKSFITEVVETNLVAFDCHWIIINE 263
            +     L     +EEL+R ++  ++ ++       ++ + ++V         H+II N 
Sbjct: 190 NDVSYRQL-----LEELDRRQE--KKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANL 242

Query: 264 EINDVDVQELVR--RSIGRLTIIRQTFPVPQNISQRCFRGNHR-ISSTLCDPKDPFAQNM 320
              D+ ++  +    ++    ++    P+   +  R  + + R    +   PK       
Sbjct: 243 GFKDISLERFIHGGANVTGFQLVDFNTPMVIKLMDRWKKLDQREYPGSETPPK------- 295

Query: 321 EISNLYIYDTVLLLANAF----HKKLEDRKWHSMASLSCIRKNSKPWQGGRSMLETIKKG 376
             ++   YD VL++A  F     +K++  +  +     C+   + PW  G  M  T+K+ 
Sbjct: 296 -YTSALTYDGVLVMAETFRSLRRQKIDISRRGNAG--DCLANPAAPWGQGIDMERTLKQV 352

Query: 377 GVSGLTGELEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTGLNGSLTDKKLEN 436
            + GLTG ++F   G   N   ++      E    G RK+G WN +  L        L N
Sbjct: 353 RIQGLTGNVQFDHYGRRVNYTMDVF-----ELKSTGPRKVGYWNDMDKLVLIQDVPTLGN 407

Query: 437 NMRGVVLRVVTV 448
           +   +  R V V
Sbjct: 408 DTAAIENRTVVV 419


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.136    0.412 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,349,066
Number of Sequences: 37866
Number of extensions: 1581771
Number of successful extensions: 3588
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 33
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 3335
Number of HSP's gapped (non-prelim): 53
length of query: 1007
length of database: 18,247,518
effective HSP length: 112
effective length of query: 895
effective length of database: 14,006,526
effective search space: 12535840770
effective search space used: 12535840770
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.