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Search of human proteins with 157266300
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157266300 membrane alanine aminopeptidase precursor [Homo
sapiens]
(967 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157266300 membrane alanine aminopeptidase precursor [Homo sap... 1964 0.0
gi|194239713 laeverin [Homo sapiens] 581 e-165
gi|132814467 glutamyl aminopeptidase [Homo sapiens] 570 e-162
gi|7019561 thyrotropin-releasing hormone degrading enzyme [Homo ... 570 e-162
gi|94818891 type 1 tumor necrosis factor receptor shedding amino... 495 e-140
gi|94818901 type 1 tumor necrosis factor receptor shedding amino... 495 e-140
gi|61742777 leucyl/cystinyl aminopeptidase isoform 1 [Homo sapiens] 478 e-135
gi|61742775 leucyl/cystinyl aminopeptidase isoform 2 [Homo sapiens] 478 e-135
gi|194306629 endoplasmic reticulum aminopeptidase 2 [Homo sapiens] 459 e-129
gi|11641261 endoplasmic reticulum aminopeptidase 2 [Homo sapiens] 459 e-129
gi|158937236 aminopeptidase puromycin sensitive [Homo sapiens] 444 e-124
gi|4505029 leukotriene A4 hydrolase [Homo sapiens] 100 7e-21
gi|40316915 arginyl aminopeptidase [Homo sapiens] 97 7e-20
gi|54020718 arginyl aminopeptidase (aminopeptidase B)-like 1 [Ho... 76 1e-13
gi|24497585 aldo-keto reductase family 1, member C4 [Homo sapiens] 36 0.20
gi|171184451 centrosome-associated protein 350 [Homo sapiens] 34 0.58
gi|66277202 podocalyxin-like isoform 1 precursor [Homo sapiens] 31 4.9
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 31 4.9
gi|4507347 TBP-associated factor 2 [Homo sapiens] 31 4.9
gi|89191868 von Willebrand factor preproprotein [Homo sapiens] 31 6.4
gi|33598950 podocalyxin-like isoform 2 precursor [Homo sapiens] 31 6.4
gi|54792133 hypothetical protein LOC25854 [Homo sapiens] 31 6.4
gi|54792131 hypothetical protein LOC25854 [Homo sapiens] 31 6.4
>gi|157266300 membrane alanine aminopeptidase precursor [Homo
sapiens]
Length = 967
Score = 1964 bits (5087), Expect = 0.0
Identities = 967/967 (100%), Positives = 967/967 (100%)
Query: 1 MAKGFYISKSLGILGILLGVAAVCTIIALSVVYSQEKNKNANSSPVASTTPSASATTNPA 60
MAKGFYISKSLGILGILLGVAAVCTIIALSVVYSQEKNKNANSSPVASTTPSASATTNPA
Sbjct: 1 MAKGFYISKSLGILGILLGVAAVCTIIALSVVYSQEKNKNANSSPVASTTPSASATTNPA 60
Query: 61 SATTLDQSKAWNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDVI 120
SATTLDQSKAWNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDVI
Sbjct: 61 SATTLDQSKAWNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDVI 120
Query: 121 IIHSKKLNYTLSQGHRVVLRGVGGSQPPDIDKTELVEPTEYLVVHLKGSLVKDSQYEMDS 180
IIHSKKLNYTLSQGHRVVLRGVGGSQPPDIDKTELVEPTEYLVVHLKGSLVKDSQYEMDS
Sbjct: 121 IIHSKKLNYTLSQGHRVVLRGVGGSQPPDIDKTELVEPTEYLVVHLKGSLVKDSQYEMDS 180
Query: 181 EFEGELADDLAGFYRSEYMEGNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHP 240
EFEGELADDLAGFYRSEYMEGNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHP
Sbjct: 181 EFEGELADDLAGFYRSEYMEGNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHP 240
Query: 241 KDLTALSNMLPKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLI 300
KDLTALSNMLPKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLI
Sbjct: 241 KDLTALSNMLPKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLI 300
Query: 301 RIWARPSAIAAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLV 360
RIWARPSAIAAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLV
Sbjct: 301 RIWARPSAIAAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLV 360
Query: 361 TYRENSLLFDPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYL 420
TYRENSLLFDPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYL
Sbjct: 361 TYRENSLLFDPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYL 420
Query: 421 GADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSKG 480
GADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSKG
Sbjct: 421 GADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSKG 480
Query: 481 ASVLRMLSSFLSEDVFKQGLASYLHTFAYQNTIYLNLWDHLQEAVNNRSIQLPTTVRDIM 540
ASVLRMLSSFLSEDVFKQGLASYLHTFAYQNTIYLNLWDHLQEAVNNRSIQLPTTVRDIM
Sbjct: 481 ASVLRMLSSFLSEDVFKQGLASYLHTFAYQNTIYLNLWDHLQEAVNNRSIQLPTTVRDIM 540
Query: 541 NRWTLQMGFPVITVDTSTGTLSQEHFLLDPDSNVTRPSEFNYVWIVPITSIRDGRQQQDY 600
NRWTLQMGFPVITVDTSTGTLSQEHFLLDPDSNVTRPSEFNYVWIVPITSIRDGRQQQDY
Sbjct: 541 NRWTLQMGFPVITVDTSTGTLSQEHFLLDPDSNVTRPSEFNYVWIVPITSIRDGRQQQDY 600
Query: 601 WLIDVRAQNDLFSTSGNEWVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRAQ 660
WLIDVRAQNDLFSTSGNEWVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRAQ
Sbjct: 601 WLIDVRAQNDLFSTSGNEWVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRAQ 660
Query: 661 IINDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAALSSLSYFKLMFDRSEVYGPMKN 720
IINDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAALSSLSYFKLMFDRSEVYGPMKN
Sbjct: 661 IINDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAALSSLSYFKLMFDRSEVYGPMKN 720
Query: 721 YLKKQVTPLFIHFRNNTNNWREIPENLMDQYSEVNAISTACSNGVPECEEMVSGLFKQWM 780
YLKKQVTPLFIHFRNNTNNWREIPENLMDQYSEVNAISTACSNGVPECEEMVSGLFKQWM
Sbjct: 721 YLKKQVTPLFIHFRNNTNNWREIPENLMDQYSEVNAISTACSNGVPECEEMVSGLFKQWM 780
Query: 781 ENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQFRNATLVNEADKLRAALACSKELWI 840
ENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQFRNATLVNEADKLRAALACSKELWI
Sbjct: 781 ENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQFRNATLVNEADKLRAALACSKELWI 840
Query: 841 LNRYLSYTLNPDLIRKQDATSTIISITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFSN 900
LNRYLSYTLNPDLIRKQDATSTIISITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFSN
Sbjct: 841 LNRYLSYTLNPDLIRKQDATSTIISITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFSN 900
Query: 901 LIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEVVLQ 960
LIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEVVLQ
Sbjct: 901 LIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEVVLQ 960
Query: 961 WFTENSK 967
WFTENSK
Sbjct: 961 WFTENSK 967
>gi|194239713 laeverin [Homo sapiens]
Length = 990
Score = 581 bits (1497), Expect = e-165
Identities = 344/955 (36%), Positives = 529/955 (55%), Gaps = 47/955 (4%)
Query: 2 AKGFYISKSLGILGILLGVAAVCTIIALSVVYSQ-----------EKNKNANSSPVA--- 47
+ GFY+S+++ +L L A + + L+ +Y ++ A SSP
Sbjct: 6 SSGFYVSRAVALLLAGLVAALLLALAVLAALYGHCERVPPSELPGLRDLEAESSPPLRQK 65
Query: 48 -STTPSASATTNPASATTLDQSKA---WNRYRLPNTLKPDSYRVTLRPYLTPND--RGLY 101
+ TP S+ A TT + W++ RLP L P Y + L P L P++ G
Sbjct: 66 PTPTPKPSSARELAVTTTPSNWRPPGPWDQLRLPPWLVPLHYDLELWPQLRPDELPAGSL 125
Query: 102 VFKGSSTVRFTCKEATDVIIIHSKKLNYTLSQGHRVVLRGVGGSQPP--DIDKTELVEPT 159
F G + C AT +++HS + ++ + G G + +D T
Sbjct: 126 PFTGRVNITVRCTVATSRLLLHSLFQDCERAEVRGPLSPGTGNATVGRVPVDDVWFALDT 185
Query: 160 EYLVVHLKGSLVKDSQYEMDSEFEGELADDLA-GFYRSEYMEGNVRKVVATTQMQAADAR 218
EY+V+ L L S YE+ F G + +DL G + + Y + R+ + +Q++ AR
Sbjct: 186 EYMVLELSEPLKPGSSYELQLSFSGLVKEDLREGLFLNVYTDQGERRALLASQLEPTFAR 245
Query: 219 KSFPCFDEPAMKAEFNITLIHPKDLTALSNMLPKGPSTPLPEDPN---WNVTEFHTTPKM 275
FPCFDEPA+KA FNIT+IH ALSNM G S ED N W VT F TTP M
Sbjct: 246 YVFPCFDEPALKATFNITMIHHPSYVALSNMPKLGQSEK--EDVNGSKWTVTTFSTTPHM 303
Query: 276 STYLLAFIVSEFDYVEKQASNGVLIRIWARPSAIAAGHGDYALNVTGPILNFFAGHYDTP 335
TYL+AF++ ++D+V + G IRIWAR AIA G D+ALN+TGPI +F ++
Sbjct: 304 PTYLVAFVICDYDHVNR-TERGKEIRIWARKDAIANGSADFALNITGPIFSFLEDLFNIS 362
Query: 336 YPLPKSDQIGLPDFNAGAMENWGLVTYRENSLLFDPLSSSSSNKERVVTVIAHELAHQWF 395
Y LPK+D I LP F+ AMENWGL+ + E+ LL +P + K + V++HE+ HQWF
Sbjct: 363 YSLPKTDIIALPSFDNHAMENWGLMIFDESGLLLEPKDQLTEKKTLISYVVSHEIGHQWF 422
Query: 396 GNLVTIEWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPL 455
GNLVT+ WWN++WLNEGFASY E+ +Y P ++ N ++ ++ D + +
Sbjct: 423 GNLVTMNWWNNIWLNEGFASYFEFEVINYFNPKLPRNEIFFSNILHNILREDHALVTRAV 482
Query: 456 STPASEINTPAQISELFDAISYSKGASVLRMLSSFLSEDVFKQGLASYLHTFAYQNTIYL 515
+ T ++I ELFD +YSKGAS+ RMLS FL+E +F L SYL TF+Y N
Sbjct: 483 AMKVENFKT-SEIQELFDIFTYSKGASMARMLSCFLNEHLFVSALKSYLKTFSYSNAEQD 541
Query: 516 NLWDHLQEAVNNRS-IQLPTTVRDIMNRWTLQMGFPVITVDTSTGTLSQEHFLLDPDSNV 574
+LW H Q A++++S + LP T+++IM+ WT Q GFPVIT++ STG + QE F L+ N
Sbjct: 542 DLWRHFQMAIDDQSTVILPATIKNIMDSWTHQSGFPVITLNVSTGVMKQEPFYLENIKNR 601
Query: 575 TRPSEFNYVWIVPITSIRDGRQQQDYWLIDVRAQNDLF-----STSGNEWVLLNLNVTGY 629
T + N WIVPI I++G Q WL + +F S S ++WV+LNLN+TGY
Sbjct: 602 TLLTS-NDTWIVPILWIKNGTTQPLVWL---DQSSKVFPEMQVSDSDHDWVILNLNMTGY 657
Query: 630 YRVNYDEENWRKIQTQLQRDHSAIPVINRAQIINDAFNLASAHKVPVTLALNNTLFLIEE 689
YRVNYD+ W+K+ QL++D AIPVI+R Q+I+DAF+L+ + + + AL T +L EE
Sbjct: 658 YRVNYDKLGWKKLNQQLEKDPKAIPVIHRLQLIDDAFSLSKNNYIEIETALELTKYLAEE 717
Query: 690 RQYMPWEAALSSLSYFKLMFDRS--EVYGPMKNYLKKQVTPLF-IHFRNNTNNWREIPEN 746
+ + W L +L L+ + + ++Y +K YL K++ ++ I+ N + ++
Sbjct: 718 DEIIVWHTVLVNLVTRDLVSEVNIYDIYSLLKRYLLKRLNLIWNIYSTIIRENVLALQDD 777
Query: 747 LMDQYSEVNAISTACSNGVPECEEMVSGLFKQWMENPNNNPIHPNLRSTVYCNAIAQGGE 806
+ S TAC G+ +C ++ LF +W+++P N +P ++ V C IA G +
Sbjct: 778 YLALISLEKLFVTACWLGLEDCLQLSKELFAKWVDHPENEIPYP-IKDVVLCYGIALGSD 836
Query: 807 EEWDFAWEQFRNATLVNEADKLRAALACSKELWILNRYLSYTLNPDLIRKQDATSTIISI 866
+EWD + N T E +L A++CSK+ WILNRY+ Y ++ + T+ I +
Sbjct: 837 KEWDILLNTYTNTTNKEEKIQLAYAMSCSKDPWILNRYMEYAISTSPFTSNE-TNIIEVV 895
Query: 867 TNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFSNLIQAVTRRFSTEYELQQLEQF 921
++ +G+ + DF+ +NW+ + Y G+ S NLI + R +T+ ++ +L+QF
Sbjct: 896 ASSEVGRYVAKDFLVNNWQAVSKRY--GTQSLINLIYTIGRTVTTDLQIVELQQF 948
>gi|132814467 glutamyl aminopeptidase [Homo sapiens]
Length = 957
Score = 570 bits (1468), Expect = e-162
Identities = 334/963 (34%), Positives = 524/963 (54%), Gaps = 58/963 (6%)
Query: 20 VAAVCTIIALSVVYSQEKNKNANSSPVASTTPS--ASATTNPASATTLDQ---------S 68
V V I+ L+V ++ + + + P + PS S+T +P+ DQ S
Sbjct: 26 VVGVGLIVGLAVGLTRSCDSSGDGGPGTAPAPSHLPSSTASPSGPPAQDQDICPASEDES 85
Query: 69 KAWNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDVIIIHSKKLN 128
W +RLP+ + P Y + ++P L + + G+ ++ T + +H ++
Sbjct: 86 GQWKNFRLPDFVNPVHYDLHVKPLLEED-----TYTGTVSISINLSAPTRYLWLHLRETR 140
Query: 129 YTLSQGHRVVLRGVGGSQPPDIDKTELVEPTEYLVVHLKGSLVK---DSQYEMDSEFEGE 185
T L+ G Q + + + EY+VV + L D Y + EF G
Sbjct: 141 IT----RLPELKRPSGDQV-QVRRCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGW 195
Query: 186 LADDLAGFYRSEYMEGNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTA 245
L L GFYR+ Y E K + T + DARKSFPCFDEP KA + I++ HPK+ A
Sbjct: 196 LNGSLVGFYRTTYTENGQVKSIVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGA 255
Query: 246 LSNM-LPKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLIRIWA 304
LSNM + K S D W T F + MSTYL+ F V +FD V++ +++G + I+
Sbjct: 256 LSNMPVAKEESV----DDKWTRTTFEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTIYV 311
Query: 305 RPSAIAAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLVTYRE 364
+P +YA N+T + ++F ++ Y LPK D+I +PDF GAMENWGL+TYRE
Sbjct: 312 QPEQKHTA--EYAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAMENWGLITYRE 369
Query: 365 NSLLFDPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYLGADY 424
+LL+DP S+SSN++RV TV+AHEL HQWFGN+VT++WW DLWLNEGFAS+ E+LG ++
Sbjct: 370 TNLLYDPKESASSNQQRVATVVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNH 429
Query: 425 AEPTWNLKDLMVLNDVYRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSKGASVL 484
AE W ++D M+L DV V D+L SSHP+ + TP +I+ +FD ISYSKG+S+L
Sbjct: 430 AETDWQMRDQMLLEDVLPVQEDDSLMSSHPIIV---TVTTPDEITSVFDGISYSKGSSIL 486
Query: 485 RMLSSFLSEDVFKQGLASYLHTFAYQNTIYLNLWDHLQEAVNNRSIQLPTTVRDIMNRWT 544
RML ++ + F++G YL + ++N + W L+EA +LP V+++M+ WT
Sbjct: 487 RMLEDWIKPENFQKGCQMYLEKYQFKNAKTSDFWAALEEA-----SRLP--VKEVMDTWT 539
Query: 545 LQMGFPVITVDTSTGTLSQEHFLLDPDSNVTR-PSEFNYVWIVPITSIRDGRQQQDYWLI 603
QMG+PV+ V+ ++Q+ FLLDP +N ++ PS+ Y W +P+ D +
Sbjct: 540 RQMGYPVLNVN-GVKNITQKRFLLDPRANPSQPPSDLGYTWNIPVKWTEDNITSSVLFNR 598
Query: 604 DVRAQNDLFST--SGNEWVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRAQI 661
+ L S+ SGN ++ +N + G+YRVNY+ W I T L +H +RA +
Sbjct: 599 SEKEGITLNSSNPSGNAFLKINPDHIGFYRVNYEVATWDSIATALSLNHKTFSSADRASL 658
Query: 662 INDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAALSSLSYFKLMF-DRSEVYGPMKN 720
I+DAF LA A + +ALN T +L E ++PW+ +S+++Y MF D E+Y ++
Sbjct: 659 IDDAFALARAQLLDYKVALNLTKYLKREENFLPWQRVISAVTYIISMFEDDKELYPMIEE 718
Query: 721 YLKKQVTPLFIHFRNNTNNWREIPENLMDQYSEVNAISTACSNGVPECEEMVSGLFKQWM 780
Y + QV P+ ++ W + ++ + + + + AC G E S LF+QW+
Sbjct: 719 YFQGQVKPI-----ADSLGWNDAGDH-VTKLLRSSVLGFACKMGDREALNNASSLFEQWL 772
Query: 781 ENPNNNPIHPNLRSTVYCNAIAQGGEE-EWDFAWEQFRNATLVNEADKLRAALACSKELW 839
+ P+ NLR VY + G E W++ EQ++ +L E +KL LA K +
Sbjct: 773 NGTVSLPV--NLRLLVYRYGMQNSGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVT 830
Query: 840 ILNRYLSYTLNPDLIRKQDATSTIISITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFS 899
+L+RYL + +LI+ QD + I I+ N G+ + W+++Q NW L N Y + +
Sbjct: 831 LLSRYLDLLKDTNLIKTQDVFTVIRYISYNSYGKNMAWNWIQLNWDYLVNRYTLNNRNLG 890
Query: 900 NLIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEVVL 959
++ + F+TE +L Q+E F + G G R EQ LE K NI+W+K+++ +
Sbjct: 891 RIV-TIAEPFNTELQLWQMESFFAKYPQAGAGEKPR--EQVLETVKNNIEWLKQHRNTIR 947
Query: 960 QWF 962
+WF
Sbjct: 948 EWF 950
>gi|7019561 thyrotropin-releasing hormone degrading enzyme [Homo
sapiens]
Length = 1024
Score = 570 bits (1468), Expect = e-162
Identities = 331/946 (34%), Positives = 495/946 (52%), Gaps = 41/946 (4%)
Query: 34 SQEKNKNANSS---PVASTTPSASATT-NPASATTLDQSKAWNRYRLPNTLKPDSYRVTL 89
S +N +A P A S T+ P S + + W + RL LKP Y + L
Sbjct: 95 SARRNHHAGGDSWQPEAGGVASPGTTSAQPPSEEEREPWEPWTQLRLSGHLKPLHYNLML 154
Query: 90 RPYLTPNDRGLYVFKGSSTVRFTCKEATDVIIIHSKKLNYTLSQGHRVVLRGVGGSQPPD 149
++ + F G V C+ AT +++H+ ++ Q + G+ P
Sbjct: 155 TAFMEN-----FTFSGEVNVEIACRNATRYVVLHASRVAVEKVQ---LAEDRAFGAVP-- 204
Query: 150 IDKTELVEPTEYLVVHLKGSLVKDSQYEMDSEFEGELADDLAGFYRSEYMEGNVRKVVAT 209
+ L T+ LVV L +L Y + + + ++L GF+RS Y+ R+ +
Sbjct: 205 VAGFFLYPQTQVLVVVLNRTLDAQRNYNLKIIYNALIENELLGFFRSSYVLHGERRFLGV 264
Query: 210 TQMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTALSNMLPKGPSTPLPEDPNWNVTEF 269
TQ ARK+FPCFDEP KA F I++ H +LSNM + T + E+ W F
Sbjct: 265 TQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMPVE---TSVFEEDGWVTDHF 321
Query: 270 HTTPKMSTYLLAFIVSEFDYVEKQASNGVLIRIWARPSAIAAGHGDYALNVTGPILNFFA 329
TP MSTY LA+ + F Y E +GV++R++ARP AI G GDYAL++T ++ F+
Sbjct: 322 SQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYALHITKRLIEFYE 381
Query: 330 GHYDTPYPLPKSDQIGLPDFNAGAMENWGLVTYRENSLLFDPLSSSSSNKERVVTVIAHE 389
++ PY LPK D + +P AMENWGL + E +L DP SS S V VI HE
Sbjct: 382 DYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHE 441
Query: 390 LAHQWFGNLVTIEWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDV-YRVMAVDA 448
+ HQWFG+LVT WW D+WL EGFA Y E++G DY P WN++ L DV + VM +D
Sbjct: 442 ICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLTDVLHEVMLLDG 501
Query: 449 LASSHPLSTPASEINTPAQISELFDAISYSKGASVLRMLSSFLSEDVFKQGLASYLHTFA 508
LASSHP+S E+ I +FD I+Y KGA+++RML++F+ VF++GL YL
Sbjct: 502 LASSHPVS---QEVLQATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHK 558
Query: 509 YQNTIYLNLWDHLQEAVNNRSIQLPTTVRDIMNRWTLQMGFPVITVDTSTGT-----LSQ 563
Y N +LW+ L EA+ + ++++M++WTLQMG+PVIT+ +T ++Q
Sbjct: 559 YGNAARNDLWNTLSEALKRNGKYV--NIQEVMDQWTLQMGYPVITILGNTTAENRIIITQ 616
Query: 564 EHFLLD--PDSNVTRPSEFNYVWIVPITSIRDGR----QQQDYWLIDVRAQNDLFSTSGN 617
+HF+ D + + +Y+W +P+T + R + W+ + + +
Sbjct: 617 QHFIYDISAKTKALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITYLDKG 676
Query: 618 EWVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRAQIINDAFNLASAHKVPVT 677
W+L N+N TGY+RVNYD NWR + QL R+H + V NRA +I+DAF+LA A +P
Sbjct: 677 SWLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRAGLIDDAFSLARAGYLPQN 736
Query: 678 LALNNTLFLIEERQYMPWEAALSSLSYFKLMFDRSEVYGPMKNYLKKQVTPLFIHFRNNT 737
+ L +L EE+ ++PW AA +L + DR E Y Y+ KQV +I
Sbjct: 737 IPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYIKLGWPK 796
Query: 738 NNWREIPENLMDQYSEV--NAISTACSNGVPECEEMVSGLFKQWMENPNNNPIHPNLRST 795
NN+ Q+ E+ I ACS G C + S L W+ + N N I N+R
Sbjct: 797 NNFNGSLVQASYQHEELRREVIMLACSFGNKHCHQQASTLISDWISS-NRNRIPLNVRDI 855
Query: 796 VYCNAIAQGGEEEWDFAWEQFRNATLVNEADKLRAALACSKELWILNRYLSYTLNPDLIR 855
VYC ++ E+ W+F W +F + T V+E L AL CS + +LNR L+ +LN +++
Sbjct: 856 VYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSDDRNLLNRLLNLSLNSEVVL 915
Query: 856 KQDATSTIISITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFSNLIQAVTRRFSTEYEL 915
QDA II + N G+ L W F + WK L YG F S LI VT +TE EL
Sbjct: 916 DQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGEL 975
Query: 916 QQLEQFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEVVLQW 961
++L+ F K+ + G + +A+E +AN++W ++ + QW
Sbjct: 976 KELKNFMKNYD----GVAAASFSRAVETVEANVRWKMLYQDELFQW 1017
>gi|94818891 type 1 tumor necrosis factor receptor shedding
aminopeptidase regulator isoform b [Homo sapiens]
Length = 941
Score = 495 bits (1275), Expect = e-140
Identities = 312/942 (33%), Positives = 477/942 (50%), Gaps = 65/942 (6%)
Query: 49 TTPSASATTNPASATTLDQSKAWNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSST 108
+TPS +T + + WN+ RLP + P Y + + LT F G++
Sbjct: 27 STPSWCQSTEASPKRSDGTPFPWNKIRLPEYVIPVHYDLLIHANLTT-----LTFWGTTK 81
Query: 109 VRFTCKEATDVIIIHSKKLNYTLSQGHRVVLRGVGGSQPPDIDKTELVEPTEYLVVHLKG 168
V T + T II+HS L + R LR G + + L P + + L
Sbjct: 82 VEITASQPTSTIILHSHHLQIS-----RATLRKGAGERLSEEPLQVLEHPRQEQIALLAP 136
Query: 169 S-LVKDSQYEMDSEFEGELADDLAGFYRSEYM--EGNVRKVVATTQMQAADARKSFPCFD 225
L+ Y + + G L++ GFY+S Y EG +R ++A+TQ + AR +FPCFD
Sbjct: 137 EPLLVGLPYTVVIHYAGNLSETFHGFYKSTYRTKEGELR-ILASTQFEPTAARMAFPCFD 195
Query: 226 EPAMKAEFNITLIHPKDLTALSNMLPKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVS 285
EPA KA F+I + A+SNM P S + E F T KMSTYL+AFI+S
Sbjct: 196 EPAFKASFSIKIRREPRHLAISNM-PLVKSVTVAE--GLIEDHFDVTVKMSTYLVAFIIS 252
Query: 286 EFDYVEKQASNGVLIRIWARPSAIAAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIG 345
+F+ V K +GV + ++A P I DYAL+ +L F+ ++ PYPLPK D
Sbjct: 253 DFESVSKITKSGVKVSVYAVPDKI--NQADYALDAAVTLLEFYEDYFSIPYPLPKQDLAA 310
Query: 346 LPDFNAGAMENWGLVTYRENSLLFDPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWN 405
+PDF +GAMENWGL TYRE++LLFD SS+S+K + +AHELAHQWFGNLVT+EWWN
Sbjct: 311 IPDFQSGAMENWGLTTYRESALLFDAEKSSASSKLGITMTVAHELAHQWFGNLVTMEWWN 370
Query: 406 DLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSTPASEINTP 465
DLWLNEGFA ++E++ P + D + M VDAL SSHP+STP + P
Sbjct: 371 DLWLNEGFAKFMEFVSVSVTHPELKVGDYF-FGKCFDAMEVDALNSSHPVSTP---VENP 426
Query: 466 AQISELFDAISYSKGASVLRMLSSFLSEDVFKQGLASYLHTFAYQNTIYLNLWDHLQEAV 525
AQI E+FD +SY KGA +L ML +LS D FK G+ YL +Y+NT +LWD +
Sbjct: 427 AQIREMFDDVSYDKGACILNMLREYLSADAFKSGIVQYLQKHSYKNTKNEDLWDSMASIC 486
Query: 526 NNRSI--------------------QLPTTVRDIMNRWTLQMGFPVITVDTSTGT---LS 562
+ Q V+ +MN WTLQ GFP+IT+ T G +
Sbjct: 487 PTDGVKGMDGFCSRSQHSSSSSHWHQEGVDVKTMMNTWTLQKGFPLITI-TVRGRNVHMK 545
Query: 563 QEHFLLDPDSNVTRPSEFNYVWIVPITSIRDGRQQQDYWLIDVRAQNDLFSTSGNEWVLL 622
QEH++ D + Y+W VP+T I +L+ + + L EW+
Sbjct: 546 QEHYMKGSDG----APDTGYLWHVPLTFITSKSDMVHRFLLKTKT-DVLILPEEVEWIKF 600
Query: 623 NLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRAQIINDAFNLASAHKVPVTLALNN 682
N+ + GYY V+Y+++ W + L+ H+A+ +RA +IN+AF L S K+ + AL+
Sbjct: 601 NVGMNGYYIVHYEDDGWDSLTGLLKGTHTAVSSNDRASLINNAFQLVSIGKLSIEKALDL 660
Query: 683 TLFLIEERQYMPWEAALSSL-SYFKLM--FDRSEVYGPMKNYLKKQVTPLFIHFRNNTNN 739
+L+L E + MP L+ L +KLM D +EV K +L + + L +
Sbjct: 661 SLYLKHETEIMPVFQGLNELIPMYKLMEKRDMNEVETQFKAFLIRLLRDLI-----DKQT 715
Query: 740 WREIPENLMDQYSEVNAISTACSNGVPECEEMVSGLFKQWMENPNNNPIHPNLRSTVYCN 799
W + ++ ++ + AC + C + G F++W E+ N + ++ V+
Sbjct: 716 WTD-EGSVSERMLRSQLLLLACVHNYQPCVQRAEGYFRKWKESNGNLSLPVDVTLAVF-- 772
Query: 800 AIAQGGEEEWDFAWEQFRNATLVNEADKLRAALACSKELWILNRYLSYTLNPDLIRKQDA 859
A+ E WDF + +++ + E ++ AL ++ L L + D I+ Q+
Sbjct: 773 AVGAQSTEGWDFLYSKYQFSLSSTEKSQIEFALCRTQNKEKLQWLLDESFKGDKIKTQEF 832
Query: 860 TSTIISITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFSNLIQAVTRRFSTEYELQQLE 919
+ I N +G L W F++ NW KL + GS S ++++ T +FST L++++
Sbjct: 833 PQILTLIGRNPVGYPLAWQFLRKNWNKLVQKFELGSSSIAHMVMGTTNQFSTRTRLEEVK 892
Query: 920 QFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEVVLQW 961
F +E GS R ++Q +E + NI W+ +N + + W
Sbjct: 893 GFFSSLKEN--GSQLRCVQQTIETIEENIGWMDKNFDKIRVW 932
>gi|94818901 type 1 tumor necrosis factor receptor shedding
aminopeptidase regulator isoform a [Homo sapiens]
Length = 948
Score = 495 bits (1275), Expect = e-140
Identities = 312/942 (33%), Positives = 477/942 (50%), Gaps = 65/942 (6%)
Query: 49 TTPSASATTNPASATTLDQSKAWNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSST 108
+TPS +T + + WN+ RLP + P Y + + LT F G++
Sbjct: 27 STPSWCQSTEASPKRSDGTPFPWNKIRLPEYVIPVHYDLLIHANLTT-----LTFWGTTK 81
Query: 109 VRFTCKEATDVIIIHSKKLNYTLSQGHRVVLRGVGGSQPPDIDKTELVEPTEYLVVHLKG 168
V T + T II+HS L + R LR G + + L P + + L
Sbjct: 82 VEITASQPTSTIILHSHHLQIS-----RATLRKGAGERLSEEPLQVLEHPRQEQIALLAP 136
Query: 169 S-LVKDSQYEMDSEFEGELADDLAGFYRSEYM--EGNVRKVVATTQMQAADARKSFPCFD 225
L+ Y + + G L++ GFY+S Y EG +R ++A+TQ + AR +FPCFD
Sbjct: 137 EPLLVGLPYTVVIHYAGNLSETFHGFYKSTYRTKEGELR-ILASTQFEPTAARMAFPCFD 195
Query: 226 EPAMKAEFNITLIHPKDLTALSNMLPKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVS 285
EPA KA F+I + A+SNM P S + E F T KMSTYL+AFI+S
Sbjct: 196 EPAFKASFSIKIRREPRHLAISNM-PLVKSVTVAE--GLIEDHFDVTVKMSTYLVAFIIS 252
Query: 286 EFDYVEKQASNGVLIRIWARPSAIAAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIG 345
+F+ V K +GV + ++A P I DYAL+ +L F+ ++ PYPLPK D
Sbjct: 253 DFESVSKITKSGVKVSVYAVPDKI--NQADYALDAAVTLLEFYEDYFSIPYPLPKQDLAA 310
Query: 346 LPDFNAGAMENWGLVTYRENSLLFDPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWN 405
+PDF +GAMENWGL TYRE++LLFD SS+S+K + +AHELAHQWFGNLVT+EWWN
Sbjct: 311 IPDFQSGAMENWGLTTYRESALLFDAEKSSASSKLGITMTVAHELAHQWFGNLVTMEWWN 370
Query: 406 DLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSTPASEINTP 465
DLWLNEGFA ++E++ P + D + M VDAL SSHP+STP + P
Sbjct: 371 DLWLNEGFAKFMEFVSVSVTHPELKVGDYF-FGKCFDAMEVDALNSSHPVSTP---VENP 426
Query: 466 AQISELFDAISYSKGASVLRMLSSFLSEDVFKQGLASYLHTFAYQNTIYLNLWDHLQEAV 525
AQI E+FD +SY KGA +L ML +LS D FK G+ YL +Y+NT +LWD +
Sbjct: 427 AQIREMFDDVSYDKGACILNMLREYLSADAFKSGIVQYLQKHSYKNTKNEDLWDSMASIC 486
Query: 526 NNRSI--------------------QLPTTVRDIMNRWTLQMGFPVITVDTSTGT---LS 562
+ Q V+ +MN WTLQ GFP+IT+ T G +
Sbjct: 487 PTDGVKGMDGFCSRSQHSSSSSHWHQEGVDVKTMMNTWTLQKGFPLITI-TVRGRNVHMK 545
Query: 563 QEHFLLDPDSNVTRPSEFNYVWIVPITSIRDGRQQQDYWLIDVRAQNDLFSTSGNEWVLL 622
QEH++ D + Y+W VP+T I +L+ + + L EW+
Sbjct: 546 QEHYMKGSDG----APDTGYLWHVPLTFITSKSDMVHRFLLKTKT-DVLILPEEVEWIKF 600
Query: 623 NLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRAQIINDAFNLASAHKVPVTLALNN 682
N+ + GYY V+Y+++ W + L+ H+A+ +RA +IN+AF L S K+ + AL+
Sbjct: 601 NVGMNGYYIVHYEDDGWDSLTGLLKGTHTAVSSNDRASLINNAFQLVSIGKLSIEKALDL 660
Query: 683 TLFLIEERQYMPWEAALSSL-SYFKLM--FDRSEVYGPMKNYLKKQVTPLFIHFRNNTNN 739
+L+L E + MP L+ L +KLM D +EV K +L + + L +
Sbjct: 661 SLYLKHETEIMPVFQGLNELIPMYKLMEKRDMNEVETQFKAFLIRLLRDLI-----DKQT 715
Query: 740 WREIPENLMDQYSEVNAISTACSNGVPECEEMVSGLFKQWMENPNNNPIHPNLRSTVYCN 799
W + ++ ++ + AC + C + G F++W E+ N + ++ V+
Sbjct: 716 WTD-EGSVSERMLRSQLLLLACVHNYQPCVQRAEGYFRKWKESNGNLSLPVDVTLAVF-- 772
Query: 800 AIAQGGEEEWDFAWEQFRNATLVNEADKLRAALACSKELWILNRYLSYTLNPDLIRKQDA 859
A+ E WDF + +++ + E ++ AL ++ L L + D I+ Q+
Sbjct: 773 AVGAQSTEGWDFLYSKYQFSLSSTEKSQIEFALCRTQNKEKLQWLLDESFKGDKIKTQEF 832
Query: 860 TSTIISITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFSNLIQAVTRRFSTEYELQQLE 919
+ I N +G L W F++ NW KL + GS S ++++ T +FST L++++
Sbjct: 833 PQILTLIGRNPVGYPLAWQFLRKNWNKLVQKFELGSSSIAHMVMGTTNQFSTRTRLEEVK 892
Query: 920 QFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEVVLQW 961
F +E GS R ++Q +E + NI W+ +N + + W
Sbjct: 893 GFFSSLKEN--GSQLRCVQQTIETIEENIGWMDKNFDKIRVW 932
>gi|61742777 leucyl/cystinyl aminopeptidase isoform 1 [Homo sapiens]
Length = 1025
Score = 478 bits (1231), Expect = e-135
Identities = 305/902 (33%), Positives = 470/902 (52%), Gaps = 51/902 (5%)
Query: 71 WNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDVIIIHSKKLNYT 130
W + RLP + P Y ++L P LT F+GS T+ + T II+HS N +
Sbjct: 163 WAQIRLPTAVVPLRYELSLHPNLTS-----MTFRGSVTISVQALQVTWNIILHSTGHNIS 217
Query: 131 LSQGHRVVLRGVGGSQPPDIDKTELVEPTEYLVVHLKGSLVKDSQYEMDSEFEGELADDL 190
RV SQ + E + +V + +L+ Y + E+ ++
Sbjct: 218 -----RVTFMSAVSSQEKQAEILEYAYHGQIAIVAPE-ALLAGHNYTLKIEYSANISSSY 271
Query: 191 AGFYRSEYM-EGNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTALSNM 249
GFY Y E N +K A TQ + AR +FPCFDEPA KA F I +I + TALSNM
Sbjct: 272 YGFYGFSYTDESNEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTALSNM 331
Query: 250 LPKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLIRIWARPSAI 309
PK S L D EF + KMSTYL+AFIV E + + NG L+ I+A P I
Sbjct: 332 -PKKSSVVL--DDGLVQDEFSESVKMSTYLVAFIVGEMKNLSQDV-NGTLVSIYAVPEKI 387
Query: 310 AAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLVTYRENSLLF 369
H YAL T +L FF +++ YPL K D + +PDF AGAMENWGL+T+RE +LL+
Sbjct: 388 GQVH--YALETTVKLLEFFQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLY 445
Query: 370 DPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYLGADYAEPTW 429
D +SS ++++ V +IAHELAHQWFGNLVT++WWNDLWLNEGFA+++EY +
Sbjct: 446 DSNTSSMADRKLVTKIIAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKI---- 501
Query: 430 NLKDLMVLNDV----YRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSKGASVLR 485
K+L D ++ M D+L SSHP+S S + + QI E+FD++SY KG+S+L
Sbjct: 502 -FKELSSYEDFLDARFKTMKKDSLNSSHPIS---SSVQSSEQIEEMFDSLSYFKGSSLLL 557
Query: 486 MLSSFLSEDVFKQGLASYLHTFAYQNTIYLNLWDHLQEAVNNRSIQLPTTVRDIMNRWTL 545
ML ++LSEDVF+ + YLH +Y + +LWD E N V+ +M WTL
Sbjct: 558 MLKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQ-----TLDVKRMMKTWTL 612
Query: 546 QMGFPVITVDTSTGTL--SQEHFLLDPDSNVTRPSEFNYVWIVPITSIRDGRQQQDYWLI 603
Q GFP++TV L QE F L+ + +PS+ +Y+W +P++ + +GR Y +
Sbjct: 613 QKGFPLVTVQKKGKELFIQQERFFLNMKPEI-QPSDTSYLWHIPLSYVTEGRNYSKYQSV 671
Query: 604 DV--RAQNDLFSTSGNEWVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRAQI 661
+ + + T WV +N+N+ GYY V+Y +++W + QL+ + + +RA +
Sbjct: 672 SLLDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINPYVLSDKDRANL 731
Query: 662 INDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAALSSLSYFKLMFDRSEVYGPMKNY 721
IN+ F LA KVP+ A + +L E P AL L+++ E G M +
Sbjct: 732 INNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTD---LIYNLLEKLGYM-DL 787
Query: 722 LKKQVTPLFIHFRN--NTNNWREIPENLMDQYSEVNAISTACSNGVPECEEMVSGLFKQW 779
+ VT +F +N W + M + + AC++ + C LF W
Sbjct: 788 ASRLVTRVFKLLQNQIQQQTWTDEGTPSMRELRSA-LLEFACTHNLGNCSTTAMKLFDDW 846
Query: 780 MENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQFRNATLVNEADKLRAALACSKELW 839
M + + ++ +TV+ + ++ W F ++ + E +K+ ALA S+++
Sbjct: 847 MASNGTQSLPTDVMTTVF--KVGAKTDKGWSFLLGKYISIGSEAEKNKILEALASSEDVR 904
Query: 840 ILNRYLSYTLNPDLIRKQDATSTIISITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFS 899
L + +LN D R Q + I ++ + G L WDFV+ NW KL + GS++
Sbjct: 905 KLYWLMKSSLNGDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSYTIQ 964
Query: 900 NLIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEVVL 959
N++ T FST+ L +++ F ++ E F R +++ALE + NI+W+++N + +
Sbjct: 965 NIVAGSTYLFSTKTHLSEVQAFFENQSEATF--RLRCVQEALEVIQLNIQWMEKNLKSLT 1022
Query: 960 QW 961
W
Sbjct: 1023 WW 1024
>gi|61742775 leucyl/cystinyl aminopeptidase isoform 2 [Homo sapiens]
Length = 1011
Score = 478 bits (1231), Expect = e-135
Identities = 305/902 (33%), Positives = 470/902 (52%), Gaps = 51/902 (5%)
Query: 71 WNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDVIIIHSKKLNYT 130
W + RLP + P Y ++L P LT F+GS T+ + T II+HS N +
Sbjct: 149 WAQIRLPTAVVPLRYELSLHPNLTS-----MTFRGSVTISVQALQVTWNIILHSTGHNIS 203
Query: 131 LSQGHRVVLRGVGGSQPPDIDKTELVEPTEYLVVHLKGSLVKDSQYEMDSEFEGELADDL 190
RV SQ + E + +V + +L+ Y + E+ ++
Sbjct: 204 -----RVTFMSAVSSQEKQAEILEYAYHGQIAIVAPE-ALLAGHNYTLKIEYSANISSSY 257
Query: 191 AGFYRSEYM-EGNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTALSNM 249
GFY Y E N +K A TQ + AR +FPCFDEPA KA F I +I + TALSNM
Sbjct: 258 YGFYGFSYTDESNEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTALSNM 317
Query: 250 LPKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLIRIWARPSAI 309
PK S L D EF + KMSTYL+AFIV E + + NG L+ I+A P I
Sbjct: 318 -PKKSSVVL--DDGLVQDEFSESVKMSTYLVAFIVGEMKNLSQDV-NGTLVSIYAVPEKI 373
Query: 310 AAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLVTYRENSLLF 369
H YAL T +L FF +++ YPL K D + +PDF AGAMENWGL+T+RE +LL+
Sbjct: 374 GQVH--YALETTVKLLEFFQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLY 431
Query: 370 DPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYLGADYAEPTW 429
D +SS ++++ V +IAHELAHQWFGNLVT++WWNDLWLNEGFA+++EY +
Sbjct: 432 DSNTSSMADRKLVTKIIAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKI---- 487
Query: 430 NLKDLMVLNDV----YRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSKGASVLR 485
K+L D ++ M D+L SSHP+S S + + QI E+FD++SY KG+S+L
Sbjct: 488 -FKELSSYEDFLDARFKTMKKDSLNSSHPIS---SSVQSSEQIEEMFDSLSYFKGSSLLL 543
Query: 486 MLSSFLSEDVFKQGLASYLHTFAYQNTIYLNLWDHLQEAVNNRSIQLPTTVRDIMNRWTL 545
ML ++LSEDVF+ + YLH +Y + +LWD E N V+ +M WTL
Sbjct: 544 MLKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQ-----TLDVKRMMKTWTL 598
Query: 546 QMGFPVITVDTSTGTL--SQEHFLLDPDSNVTRPSEFNYVWIVPITSIRDGRQQQDYWLI 603
Q GFP++TV L QE F L+ + +PS+ +Y+W +P++ + +GR Y +
Sbjct: 599 QKGFPLVTVQKKGKELFIQQERFFLNMKPEI-QPSDTSYLWHIPLSYVTEGRNYSKYQSV 657
Query: 604 DV--RAQNDLFSTSGNEWVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRAQI 661
+ + + T WV +N+N+ GYY V+Y +++W + QL+ + + +RA +
Sbjct: 658 SLLDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINPYVLSDKDRANL 717
Query: 662 INDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAALSSLSYFKLMFDRSEVYGPMKNY 721
IN+ F LA KVP+ A + +L E P AL L+++ E G M +
Sbjct: 718 INNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTD---LIYNLLEKLGYM-DL 773
Query: 722 LKKQVTPLFIHFRN--NTNNWREIPENLMDQYSEVNAISTACSNGVPECEEMVSGLFKQW 779
+ VT +F +N W + M + + AC++ + C LF W
Sbjct: 774 ASRLVTRVFKLLQNQIQQQTWTDEGTPSMRELRSA-LLEFACTHNLGNCSTTAMKLFDDW 832
Query: 780 MENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQFRNATLVNEADKLRAALACSKELW 839
M + + ++ +TV+ + ++ W F ++ + E +K+ ALA S+++
Sbjct: 833 MASNGTQSLPTDVMTTVF--KVGAKTDKGWSFLLGKYISIGSEAEKNKILEALASSEDVR 890
Query: 840 ILNRYLSYTLNPDLIRKQDATSTIISITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFS 899
L + +LN D R Q + I ++ + G L WDFV+ NW KL + GS++
Sbjct: 891 KLYWLMKSSLNGDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSYTIQ 950
Query: 900 NLIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEVVL 959
N++ T FST+ L +++ F ++ E F R +++ALE + NI+W+++N + +
Sbjct: 951 NIVAGSTYLFSTKTHLSEVQAFFENQSEATF--RLRCVQEALEVIQLNIQWMEKNLKSLT 1008
Query: 960 QW 961
W
Sbjct: 1009 WW 1010
>gi|194306629 endoplasmic reticulum aminopeptidase 2 [Homo sapiens]
Length = 960
Score = 459 bits (1182), Expect = e-129
Identities = 308/930 (33%), Positives = 459/930 (49%), Gaps = 67/930 (7%)
Query: 71 WNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDVIIIHSKKLNYT 130
W RLP+ + P Y + + P LT D F S + AT II+HSK L T
Sbjct: 64 WQELRLPSVVIPLHYDLFVHPNLTSLD-----FVASEKIEVLVSNATQFIILHSKDLEIT 118
Query: 131 LSQGHRVVLRGVGGSQ--PPDIDKTELVEPT-EYLVVHLKGSLVKDSQYEMDSEFEGELA 187
L+ S+ P + L P E + + + L +Y + +F+ +L
Sbjct: 119 -----NATLQSEEDSRYMKPGKELKVLSYPAHEQIALLVPEKLTPHLKYYVAMDFQAKLG 173
Query: 188 DDLAGFYRSEYME-GNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTAL 246
D GFY+S Y G +++A T + AR +FPCFDEP KA F+I + AL
Sbjct: 174 DGFEGFYKSTYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRESRHIAL 233
Query: 247 SNMLPKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLIRIWARP 306
SNM PK + L + F TT KMSTYL+A+IV +F + S+GV + I+A P
Sbjct: 234 SNM-PKVKTIEL--EGGLLEDHFETTVKMSTYLVAYIVCDFHSLSGFTSSGVKVSIYASP 290
Query: 307 SAIAAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLVTYRENS 366
H YAL + +L+F+ ++D YPL K D I +PDF GAMENWGL+TYRE S
Sbjct: 291 DKRNQTH--YALQASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETS 348
Query: 367 LLFDPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYLGADYAE 426
LLFDP +SS+S+K V VIAHELAHQWFGNLVT+EWWND+WL EGFA Y+E + +
Sbjct: 349 LLFDPKTSSASDKLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNATY 408
Query: 427 PTWNLKDLMVLNDVYRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSKGASVLRM 486
P D LN + V+ D+L SS P+S PA TP QI E+FD +SY+KGA +L M
Sbjct: 409 PELQFDDYF-LNVCFEVITKDSLNSSRPISKPAE---TPTQIQEMFDEVSYNKGACILNM 464
Query: 487 LSSFLSEDVFKQGLASYLHTFAYQNTIYLNLWDHLQEA------------------VNNR 528
L FL E+ F++G+ YL F+Y+N +LW L + +N
Sbjct: 465 LKDFLGEEKFQKGIIQYLKKFSYRNAKNDDLWSSLSNSCLESDFTSGGVCHSDPKMTSNM 524
Query: 529 SIQLPTT--VRDIMNRWTLQMGFPVITV--DTSTGTLSQEHFLL-----DPDSNVTRPSE 579
L V+++M WTLQ G P++ V D + L QE FL DP+ R +
Sbjct: 525 LAFLGENAEVKEMMTTWTLQKGIPLLVVKQDGCSLRLQQERFLQGVFQEDPE---WRALQ 581
Query: 580 FNYVWIVPITSIRDGRQQQDYWLIDVRAQNDLFSTSGNEWVLLNLNVTGYYRVNYDEENW 639
Y+W +P+T ++ + L WV N++ GYY V+Y+ W
Sbjct: 582 ERYLWHIPLTYSTSSSNVIHRHILKSKTDT-LDLPEKTSWVKFNVDSNGYYIVHYEGHGW 640
Query: 640 RKIQTQLQRDHSAIPVINRAQIINDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAAL 699
++ TQL ++H+ + +R +I+D F L A ++ + AL+ T +L E L
Sbjct: 641 DQLITQLNQNHTLLRPKDRVGLIHDVFQLVGAGRLTLDKALDMTYYLQHETSSPALLEGL 700
Query: 700 SSLSYFKLMFDR---SEVYGPMKNYLKKQVTPLFIHFRNNTNNWREIPENLMDQYSEVNA 756
S L F M DR S++ +K YL + P+ + +W + ++ D+
Sbjct: 701 SYLESFYHMMDRRNISDISENLKRYLLQYFKPVI-----DRQSWSD-KGSVWDRMLRSAL 754
Query: 757 ISTACSNGVPECEEMVSGLFKQWMENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQF 816
+ AC C + + LF QWME+ I ++ VY ++ W++ EQ+
Sbjct: 755 LKLACDLNHAPCIQKAAELFSQWMESSGKLNIPTDVLKIVY--SVGAQTTAGWNYLLEQY 812
Query: 817 RNATLVNEADKLRAALACSKELWILNRYLSYTLNPDLIRKQDATSTIISITNNVIGQGLV 876
+ E +K+ AL+ SK L + + + +I+ Q+ + + +I GQ L
Sbjct: 813 ELSMSSAEQNKILYALSTSKHQEKLLKLIELGMEGKVIKTQNLAALLHAIARRPKGQQLA 872
Query: 877 WDFVQSNWKKLFNDYGGGSFSFSNLIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRA 936
WDFV+ NW L + GS+ +I T FS++ +LQ+++ F + E GS
Sbjct: 873 WDFVRENWTHLLKKFDLGSYDIRMIISGTTAHFSSKDKLQEVKLFFESLEAQ--GSHLDI 930
Query: 937 LEQALEKTKANIKWVKENKEVVLQWFTENS 966
+ LE NIKW+++N + W N+
Sbjct: 931 FQTVLETITKNIKWLEKNLPTLRTWLMVNT 960
>gi|11641261 endoplasmic reticulum aminopeptidase 2 [Homo sapiens]
Length = 960
Score = 459 bits (1182), Expect = e-129
Identities = 308/930 (33%), Positives = 459/930 (49%), Gaps = 67/930 (7%)
Query: 71 WNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDVIIIHSKKLNYT 130
W RLP+ + P Y + + P LT D F S + AT II+HSK L T
Sbjct: 64 WQELRLPSVVIPLHYDLFVHPNLTSLD-----FVASEKIEVLVSNATQFIILHSKDLEIT 118
Query: 131 LSQGHRVVLRGVGGSQ--PPDIDKTELVEPT-EYLVVHLKGSLVKDSQYEMDSEFEGELA 187
L+ S+ P + L P E + + + L +Y + +F+ +L
Sbjct: 119 -----NATLQSEEDSRYMKPGKELKVLSYPAHEQIALLVPEKLTPHLKYYVAMDFQAKLG 173
Query: 188 DDLAGFYRSEYME-GNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTAL 246
D GFY+S Y G +++A T + AR +FPCFDEP KA F+I + AL
Sbjct: 174 DGFEGFYKSTYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRESRHIAL 233
Query: 247 SNMLPKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLIRIWARP 306
SNM PK + L + F TT KMSTYL+A+IV +F + S+GV + I+A P
Sbjct: 234 SNM-PKVKTIEL--EGGLLEDHFETTVKMSTYLVAYIVCDFHSLSGFTSSGVKVSIYASP 290
Query: 307 SAIAAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLVTYRENS 366
H YAL + +L+F+ ++D YPL K D I +PDF GAMENWGL+TYRE S
Sbjct: 291 DKRNQTH--YALQASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETS 348
Query: 367 LLFDPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYLGADYAE 426
LLFDP +SS+S+K V VIAHELAHQWFGNLVT+EWWND+WL EGFA Y+E + +
Sbjct: 349 LLFDPKTSSASDKLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNATY 408
Query: 427 PTWNLKDLMVLNDVYRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSKGASVLRM 486
P D LN + V+ D+L SS P+S PA TP QI E+FD +SY+KGA +L M
Sbjct: 409 PELQFDDYF-LNVCFEVITKDSLNSSRPISKPAE---TPTQIQEMFDEVSYNKGACILNM 464
Query: 487 LSSFLSEDVFKQGLASYLHTFAYQNTIYLNLWDHLQEA------------------VNNR 528
L FL E+ F++G+ YL F+Y+N +LW L + +N
Sbjct: 465 LKDFLGEEKFQKGIIQYLKKFSYRNAKNDDLWSSLSNSCLESDFTSGGVCHSDPKMTSNM 524
Query: 529 SIQLPTT--VRDIMNRWTLQMGFPVITV--DTSTGTLSQEHFLL-----DPDSNVTRPSE 579
L V+++M WTLQ G P++ V D + L QE FL DP+ R +
Sbjct: 525 LAFLGENAEVKEMMTTWTLQKGIPLLVVKQDGCSLRLQQERFLQGVFQEDPE---WRALQ 581
Query: 580 FNYVWIVPITSIRDGRQQQDYWLIDVRAQNDLFSTSGNEWVLLNLNVTGYYRVNYDEENW 639
Y+W +P+T ++ + L WV N++ GYY V+Y+ W
Sbjct: 582 ERYLWHIPLTYSTSSSNVIHRHILKSKTDT-LDLPEKTSWVKFNVDSNGYYIVHYEGHGW 640
Query: 640 RKIQTQLQRDHSAIPVINRAQIINDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAAL 699
++ TQL ++H+ + +R +I+D F L A ++ + AL+ T +L E L
Sbjct: 641 DQLITQLNQNHTLLRPKDRVGLIHDVFQLVGAGRLTLDKALDMTYYLQHETSSPALLEGL 700
Query: 700 SSLSYFKLMFDR---SEVYGPMKNYLKKQVTPLFIHFRNNTNNWREIPENLMDQYSEVNA 756
S L F M DR S++ +K YL + P+ + +W + ++ D+
Sbjct: 701 SYLESFYHMMDRRNISDISENLKRYLLQYFKPVI-----DRQSWSD-KGSVWDRMLRSAL 754
Query: 757 ISTACSNGVPECEEMVSGLFKQWMENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQF 816
+ AC C + + LF QWME+ I ++ VY ++ W++ EQ+
Sbjct: 755 LKLACDLNHAPCIQKAAELFSQWMESSGKLNIPTDVLKIVY--SVGAQTTAGWNYLLEQY 812
Query: 817 RNATLVNEADKLRAALACSKELWILNRYLSYTLNPDLIRKQDATSTIISITNNVIGQGLV 876
+ E +K+ AL+ SK L + + + +I+ Q+ + + +I GQ L
Sbjct: 813 ELSMSSAEQNKILYALSTSKHQEKLLKLIELGMEGKVIKTQNLAALLHAIARRPKGQQLA 872
Query: 877 WDFVQSNWKKLFNDYGGGSFSFSNLIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRA 936
WDFV+ NW L + GS+ +I T FS++ +LQ+++ F + E GS
Sbjct: 873 WDFVRENWTHLLKKFDLGSYDIRMIISGTTAHFSSKDKLQEVKLFFESLEAQ--GSHLDI 930
Query: 937 LEQALEKTKANIKWVKENKEVVLQWFTENS 966
+ LE NIKW+++N + W N+
Sbjct: 931 FQTVLETITKNIKWLEKNLPTLRTWLMVNT 960
>gi|158937236 aminopeptidase puromycin sensitive [Homo sapiens]
Length = 919
Score = 444 bits (1142), Expect = e-124
Identities = 296/907 (32%), Positives = 456/907 (50%), Gaps = 65/907 (7%)
Query: 75 RLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDVIIIHSKKLNYTLS-- 132
RLP + P +Y + L+P L + F+G ++AT+ I+++ ++ +
Sbjct: 53 RLPADVSPINYSLCLKPDLLD-----FTFEGKLEAAAQVRQATNQIVMNCADIDIITASY 107
Query: 133 --QGHRVVLRGVGGSQPPDIDKTELVEPTEYLVVHLKGSLVKDSQYEMDSEFEGELADDL 190
+G + G + + +K L P S ++ + +F GEL D +
Sbjct: 108 APEGDEEI-HATGFNYQNEDEKVTLSFP----------STLQTGTGTLKIDFVGELNDKM 156
Query: 191 AGFYRSEYM--EGNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTALSN 248
GFYRS+Y G VR A TQ +A DAR++FPC+DEPA+KA F+I+L+ PKD ALSN
Sbjct: 157 KGFYRSKYTTPSGEVR-YAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSN 215
Query: 249 MLPKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLIRIWARPSA 308
M P P+D N +F TP MSTYL+AF+V E+D+VE ++ +GV +R++
Sbjct: 216 MNVIDRK-PYPDDENLVEVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGK 274
Query: 309 IAAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLVTYRENSLL 368
A G +AL V L F+ +++ PYPLPK D I + DF AGAMENWGLVTYRE +LL
Sbjct: 275 --AEQGKFALEVAAKTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALL 332
Query: 369 FDPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYLGADYAEPT 428
DP +S SS+++ V V+ HELAHQWFGNLVT+EWW LWLNEGFAS++EYL D+ P
Sbjct: 333 IDPKNSCSSSRQWVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPE 392
Query: 429 WNLKDLMVLNDVYRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSKGASVLRMLS 488
+++ V D R +DAL +SHP+ + P+++ E+FDAISYSKGASV+RML
Sbjct: 393 YDIWTQFVSADYTRAQELDALDNSHPIEV---SVGHPSEVDEIFDAISYSKGASVIRMLH 449
Query: 489 SFLSEDVFKQGLASYLHTFAYQNTIYLNLWDHLQEAVNNRSIQLPTTVRDIMNRWTLQMG 548
++ + FK+G+ YL F +N +LW+ L+ A + +MN WT QMG
Sbjct: 450 DYIGDKDFKKGMNMYLTKFQQKNAATEDLWESLENASGK-------PIAAVMNTWTKQMG 502
Query: 549 FPVITV------DTSTGTLSQEHFLLDPDSNVTRPSEFNYVWIVPIT--SIRDGRQQQDY 600
FP+I V D LSQ+ F + + E W+VPIT + D Q +
Sbjct: 503 FPLIYVEAEQVEDDRLLRLSQKKFC----AGGSYVGEDCPQWMVPITISTSEDPNQAKLK 558
Query: 601 WLIDVRAQN-DLFSTSGNEWVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRA 659
L+D N L + ++WV LNL G+YR Y + + RD S +P ++R
Sbjct: 559 ILMDKPEMNVVLKNVKPDQWVKLNLGTVGFYRTQYSSAMLESLLPGI-RDLS-LPPVDRL 616
Query: 660 QIINDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAALSSLSYFKLMFDRSEVYGPMK 719
+ ND F+LA A + L + E Y W +L + ++ Y ++
Sbjct: 617 GLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNLGILSTLLSHTDFYEEIQ 676
Query: 720 NYLKKQVTPLFIHFRNNTNNWREIP-ENLMDQYSEVNAISTACSNGVPECEEMVSGLFKQ 778
++K +P+ W P E +D + G E FK
Sbjct: 677 EFVKDVFSPI-----GERLGWDPKPGEGHLDALLRGLVLGKLGKAGHKATLEEARRRFKD 731
Query: 779 WMENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQFRNATLVNEADKLRAALACSKEL 838
+E + +LRS VY + G D + + A + E +++ L +
Sbjct: 732 HVE--GKQILSADLRSPVYLTVLKHGDGTTLDIMLKLHKQADMQEEKNRIERVLGATLLP 789
Query: 839 WILNRYLSYTLNPDLIRKQDATSTIISIT-NNVIGQGLVWDFVQSNWKKLFNDYGGGSFS 897
++ + L++ L+ + +R QD S I + + G+ W F++ NW++L+N Y GG F
Sbjct: 790 DLIQKVLTFALSEE-VRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEELYNRYQGG-FL 847
Query: 898 FSNLIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEV 957
S LI+ F+ + +++ F + + S R ++Q E N W+K + E
Sbjct: 848 ISRLIKLSVEGFAVDKMAGEVKAFFESHPAP---SAERTIQQCCENILLNAAWLKRDAES 904
Query: 958 VLQWFTE 964
+ Q+ +
Sbjct: 905 IHQYLLQ 911
>gi|4505029 leukotriene A4 hydrolase [Homo sapiens]
Length = 611
Score = 100 bits (249), Expect = 7e-21
Identities = 100/393 (25%), Positives = 164/393 (41%), Gaps = 28/393 (7%)
Query: 164 VHLKGSLVKDSQYEMDSEFEGELADDLAGFYRSEYMEGNVRKVVATTQMQAADARKSFPC 223
+ L +L K+ + ++ FE + E G + + Q QA R PC
Sbjct: 89 ISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFS-QCQAIHCRAILPC 147
Query: 224 FDEPAMKAEFNITLIHPKDLTALSNMLPKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFI 283
D P++K + + PK+L AL + + G TP PEDP+ + +F + YL+A +
Sbjct: 148 QDTPSVKLTYTAEVSVPKELVALMSAIRDG-ETPDPEDPSRKIYKFIQKVPIPCYLIALV 206
Query: 284 VSEFDYVEKQASNGVLIRIWARPSAIAAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQ 343
V + G +W+ + Y + T +L A PY + D
Sbjct: 207 VGALE----SRQIGPRTLVWSEKEQVEKSA--YEFSETESMLKI-AEDLGGPYVWGQYDL 259
Query: 344 IGLP-DFNAGAMENWGLVTYRENSLLFDPLSSSSSNKERVVTVIAHELAHQWFGNLVTIE 402
+ LP F G MEN +T+ +LL S S+ VIAHE++H W GNLVT +
Sbjct: 260 LVLPPSFPYGGMEN-PCLTFVTPTLLAGDKSLSN--------VIAHEISHSWTGNLVTNK 310
Query: 403 WWNDLWLNEGFASYVE--YLGADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSTPAS 460
W+ WLNEG Y+E G + E + L ++ +V +HP +
Sbjct: 311 TWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQN--SVKTFGETHPFTKLVV 368
Query: 461 EINTPAQISELFDAISYSKGASVLRMLSSFL-SEDVFKQGLASYLHTFAYQNTIYLNLWD 519
++ T + ++ Y KG ++L L L ++F L +Y+ F+Y+ +I + W
Sbjct: 369 DL-TDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYK-SITTDDWK 426
Query: 520 HLQEAVNNRSIQLPTTVRDIMNRWTLQMGFPVI 552
+ + + V N W G P I
Sbjct: 427 DFLYSYFKDKVDVLNQVD--WNAWLYSPGLPPI 457
>gi|40316915 arginyl aminopeptidase [Homo sapiens]
Length = 650
Score = 97.1 bits (240), Expect = 7e-20
Identities = 97/368 (26%), Positives = 151/368 (41%), Gaps = 43/368 (11%)
Query: 204 RKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTAL---SNMLPKGPSTPLPE 260
+K TQ QA R FPCFD PA+K +++ + P TA+ S +GP
Sbjct: 162 KKPFVYTQGQAVLNRAFFPCFDTPAVKYKYSALIEVPDGFTAVMSASTWEKRGP------ 215
Query: 261 DPNWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLIRIWARPSAIAAGHGDYALNV 320
N F + +YL+A + + A G R+WA P I A +Y
Sbjct: 216 ----NKFFFQMCQPIPSYLIALAIGDL----VSAEVGPRSRVWAEPCLIDAAKEEY---- 263
Query: 321 TGPILNFFAGHYDT--PYPLPKSDQIGLP-DFNAGAMENWGLVTYRENSLLFDPLSSSSS 377
G I F A PY + D + +P F G MEN +T+ LL +
Sbjct: 264 NGVIEEFLATGEKLFGPYVWGRYDLLFMPPSFPFGGMEN-PCLTFVTPCLL--------A 314
Query: 378 NKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVE-YLGADYAEPTWNLKDLMV 436
+ VI HE++H WFGNLVT W + WLNEGF Y + + + +
Sbjct: 315 GDRSLADVIIHEISHSWFGNLVTNANWGEFWLNEGFTMYAQRRISTILFGAAYTCLEAAT 374
Query: 437 LNDVYRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSKGASVLRMLSSFL-SEDV 495
+ R +D +PL+ +I + ++ Y KG + L+ + +D
Sbjct: 375 GRALLR-QHMDITGEENPLNKLRVKIEPGVDPDDTYNETPYEKGFCFVSYLAHLVGDQDQ 433
Query: 496 FKQGLASYLHTFAYQNTI---YLNLW-DHLQEAVNNRSIQLPTTVRDIMNRWTLQMGFPV 551
F L +Y+H F +++ + +L+ + ++ E R +P D RW G+P
Sbjct: 434 FDSFLKAYVHEFKFRSILADDFLDFYLEYFPELKKKRVDIIPGFEFD---RWLNTPGWPP 490
Query: 552 ITVDTSTG 559
D S G
Sbjct: 491 YLPDLSPG 498
>gi|54020718 arginyl aminopeptidase (aminopeptidase B)-like 1 [Homo
sapiens]
Length = 494
Score = 76.3 bits (186), Expect = 1e-13
Identities = 80/323 (24%), Positives = 128/323 (39%), Gaps = 42/323 (13%)
Query: 266 VTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLIRIWARPSAIAAGHGDYALNVTGPIL 325
V FH + YL+A + + K A G R+WA P + ++G +
Sbjct: 14 VFHFHMEHPVPAYLVALVAGDL----KPADIGPRSRVWAEPCLLPTATS----KLSGAVE 65
Query: 326 NFF--AGHYDTPYPLPKSDQIGLP-DFNAGAMENWGLVTYRENSLLFDPLSSSSSNKERV 382
+ A PY + D + LP F AMEN L +SS + E +
Sbjct: 66 QWLSAAERLYGPYMWGRYDIVFLPPSFPIVAMENPCLTFI---------ISSILESDEFL 116
Query: 383 VTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVE--YLGADYAEPTWNLKDLMVLNDV 440
V + HE+AH WFGN VT W ++WL+EG A+Y + Y L+ L+ +
Sbjct: 117 VIDVIHEVAHSWFGNAVTNATWEEMWLSEGLATYAQRRITTETYGAAFTCLETAFRLDAL 176
Query: 441 YRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSKGASVLRMLSSFLSE-DVFKQG 499
+R M + L P+S ++ S L + +Y KG + LS + F
Sbjct: 177 HRQMKL--LGEDSPVSKLQVKLEPGVNPSHLMNLFTYEKGYCFVYYLSQLCGDPQRFDDF 234
Query: 500 LASYLHTFAYQNTIYLNLWDHLQE---AVNNRSIQLPTTVRDIMNRWTLQMGFPVITVDT 556
L +Y+ + + + + +L D + +S+ + RW G P+ D
Sbjct: 235 LRAYVEKYKFTSVVAQDLLDSFLSFFPELKEQSVDCRAGLE--FERWLNATGPPLAEPDL 292
Query: 557 STGTLSQEHFLLDPDSNVTRPSE 579
S G S++TRP E
Sbjct: 293 SQG------------SSLTRPVE 303
>gi|24497585 aldo-keto reductase family 1, member C4 [Homo sapiens]
Length = 323
Score = 35.8 bits (81), Expect = 0.20
Identities = 40/151 (26%), Positives = 69/151 (45%), Gaps = 15/151 (9%)
Query: 131 LSQGHRVVLRGVGGSQPPDIDKTELVEPTEYLVVHLKGSLVKDSQYEMDSEFEGELADDL 190
L+ GH + + G G PP++ + VE T+ + G DS Y ++E + LA
Sbjct: 10 LNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIE--AGFRHIDSAYLYNNEEQVGLA--- 64
Query: 191 AGFYRSEYMEGNVRK--VVATTQMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTALS- 247
RS+ +G+V++ + T+++ + P +PA+++ + DL L
Sbjct: 65 ---IRSKIADGSVKREDIFYTSKLWCTFFQ---PQMVQPALESSLKKLQLDYVDLYLLHF 118
Query: 248 NMLPKGPSTPLPEDPNWNVTEFHTTPKMSTY 278
M K TPLP+D N V F T +T+
Sbjct: 119 PMALKPGETPLPKDENGKVI-FDTVDLSATW 148
>gi|171184451 centrosome-associated protein 350 [Homo sapiens]
Length = 3117
Score = 34.3 bits (77), Expect = 0.58
Identities = 24/76 (31%), Positives = 36/76 (47%), Gaps = 11/76 (14%)
Query: 882 SNWKKLFNDYGGGSFSFSNLIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALEQAL 941
S K+L + GG SFS + R++ E E++ Q S R E+AL
Sbjct: 1660 STAKELNMPFSGGQDSFSKFTMEMVRQYMKEEEMRAAHQ----------SSLLRLREKAL 1709
Query: 942 -EKTKANIKWVKENKE 956
EKTKA + W++ K+
Sbjct: 1710 KEKTKAELAWLEHQKK 1725
>gi|66277202 podocalyxin-like isoform 1 precursor [Homo sapiens]
Length = 558
Score = 31.2 bits (69), Expect = 4.9
Identities = 26/84 (30%), Positives = 36/84 (42%), Gaps = 7/84 (8%)
Query: 15 GILLGVAAVCTIIALSVVYSQEKNKNANSSPVASTTPSASATTNPASATTLDQSKAWNRY 74
G L +A+ I S V SQ + ++ P +ST PS+ T P S T A
Sbjct: 254 GDLPTLASQSAGITASSVISQRTQQTSSQMPASSTAPSSQETVQPTSPAT-----ALRTP 308
Query: 75 RLPNTL--KPDSYRVTLRPYLTPN 96
LP T+ P + T R TP+
Sbjct: 309 TLPETMSSSPTAASTTHRYPKTPS 332
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 31.2 bits (69), Expect = 4.9
Identities = 22/65 (33%), Positives = 33/65 (50%), Gaps = 1/65 (1%)
Query: 719 KNY-LKKQVTPLFIHFRNNTNNWREIPENLMDQYSEVNAISTACSNGVPECEEMVSGLFK 777
KN+ L++QVT L +N + + ++ ENL DQ E A A + V E V+ L
Sbjct: 569 KNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNS 628
Query: 778 QWMEN 782
Q E+
Sbjct: 629 QLNES 633
>gi|4507347 TBP-associated factor 2 [Homo sapiens]
Length = 1199
Score = 31.2 bits (69), Expect = 4.9
Identities = 35/185 (18%), Positives = 79/185 (42%), Gaps = 25/185 (13%)
Query: 386 IAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYLGADYAEPTWNLKDL--MVLNDVYRV 443
+A LA Q+FG ++ W+D W+ +G + Y+ L + + T+ + + + ++ ++
Sbjct: 346 LAQSLAQQFFGCFISRMSWSDEWVLKGISGYIYGL---WMKKTFGVNEYRHWIKEELDKI 402
Query: 444 MAVDALASS---HPL-------STPAS----EINTPAQISELFDAISYSKGASVLRMLSS 489
+A + HP+ PAS I P +S + + K V+R++ +
Sbjct: 403 VAYELKTGGVLLHPIFGGGKEKDNPASHLHFSIKHPHTLSWEYYTMFQCKAHLVMRLIEN 462
Query: 490 FLSEDVFKQ------GLASYLHTFAYQNTIYLNLWDHLQEAVNNRSIQLPTTVRDIMNRW 543
+S + Q LAS + +Q+ ++ + + + S ++ ++ +W
Sbjct: 463 RISMEFMLQVFNKLLSLASTASSQKFQSHMWSQMLVSTSGFLKSISNVSGKDIQPLIKQW 522
Query: 544 TLQMG 548
Q G
Sbjct: 523 VDQSG 527
>gi|89191868 von Willebrand factor preproprotein [Homo sapiens]
Length = 2813
Score = 30.8 bits (68), Expect = 6.4
Identities = 27/105 (25%), Positives = 41/105 (39%), Gaps = 13/105 (12%)
Query: 257 PLPEDPNWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLIRIWARPSA-------- 308
P+ P+ N+ + K + AF++S D +E+Q V P A
Sbjct: 1413 PVGIGPHANLKQIRLIEKQAPENKAFVLSSVDELEQQRDEIVSYLCDLAPEAPPPTLPPD 1472
Query: 309 ---IAAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFN 350
+ G G ++ GP N D + L SD+IG DFN
Sbjct: 1473 MAQVTVGPGLLGVSTLGPKRNSMV--LDVAFVLEGSDKIGEADFN 1515
>gi|33598950 podocalyxin-like isoform 2 precursor [Homo sapiens]
Length = 526
Score = 30.8 bits (68), Expect = 6.4
Identities = 26/91 (28%), Positives = 39/91 (42%), Gaps = 8/91 (8%)
Query: 8 SKSLGILGILLGVAAVCTIIALSVVYSQEKNKNANSSPVASTTPSASATTNPASATTLDQ 67
S ++ I G + T + SV+ SQ + ++ P +ST PS+ T P S T
Sbjct: 216 SSTVAIPGYTFTSPGMTTTLPSSVI-SQRTQQTSSQMPASSTAPSSQETVQPTSPAT--- 271
Query: 68 SKAWNRYRLPNTL--KPDSYRVTLRPYLTPN 96
A LP T+ P + T R TP+
Sbjct: 272 --ALRTPTLPETMSSSPTAASTTHRYPKTPS 300
>gi|54792133 hypothetical protein LOC25854 [Homo sapiens]
Length = 482
Score = 30.8 bits (68), Expect = 6.4
Identities = 30/132 (22%), Positives = 50/132 (37%), Gaps = 15/132 (11%)
Query: 58 NPASATTLDQSKAWNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEAT 117
NP + + L + W R L RV R + P D+G+ F+GS+ +
Sbjct: 8 NPQTQSLLAECGEWTRRSL-------HLRVLGRQLILPTDKGVQHFQGSTPASAVHRPPL 60
Query: 118 DVIIIHSKKLNYTLSQGHRVVLRGVGGSQPPDIDKTELVEPTEYLVVHLKGSLVKDSQYE 177
HS + G ++V + S P D T + + T S +++ Y
Sbjct: 61 SA-CGHSSNIRELCISGSQIVPAALSASALPGPDDTGVADLT-------ARSSLEEEVYH 112
Query: 178 MDSEFEGELADD 189
+D + E A D
Sbjct: 113 VDGKIEEYFAFD 124
>gi|54792131 hypothetical protein LOC25854 [Homo sapiens]
Length = 482
Score = 30.8 bits (68), Expect = 6.4
Identities = 30/132 (22%), Positives = 50/132 (37%), Gaps = 15/132 (11%)
Query: 58 NPASATTLDQSKAWNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEAT 117
NP + + L + W R L RV R + P D+G+ F+GS+ +
Sbjct: 8 NPQTQSLLAECGEWTRRSL-------HLRVLGRQLILPTDKGVQHFQGSTPASAVHRPPL 60
Query: 118 DVIIIHSKKLNYTLSQGHRVVLRGVGGSQPPDIDKTELVEPTEYLVVHLKGSLVKDSQYE 177
HS + G ++V + S P D T + + T S +++ Y
Sbjct: 61 SA-CGHSSNIRELCISGSQIVPAALSASALPGPDDTGVADLT-------ARSSLEEEVYH 112
Query: 178 MDSEFEGELADD 189
+D + E A D
Sbjct: 113 VDGKIEEYFAFD 124
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.132 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,470,584
Number of Sequences: 37866
Number of extensions: 1622550
Number of successful extensions: 4720
Number of sequences better than 10.0: 23
Number of HSP's better than 10.0 without gapping: 17
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 4578
Number of HSP's gapped (non-prelim): 26
length of query: 967
length of database: 18,247,518
effective HSP length: 112
effective length of query: 855
effective length of database: 14,006,526
effective search space: 11975579730
effective search space used: 11975579730
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.