Guide to the Human Genome
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Search of human proteins with 15718712

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|15718712 caspase 8 isoform E [Homo sapiens]
         (235 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|15718712 caspase 8 isoform E [Homo sapiens]                        456   e-129
gi|122056476 caspase 8 isoform G precursor [Homo sapiens]             382   e-106
gi|15718706 caspase 8 isoform B precursor [Homo sapiens]              382   e-106
gi|122056474 caspase 8 isoform C precursor [Homo sapiens]             353   9e-98
gi|15718708 caspase 8 isoform C precursor [Homo sapiens]              353   9e-98
gi|15718704 caspase 8 isoform A precursor [Homo sapiens]              336   9e-93
gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens]          88   7e-18
gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens]          88   7e-18
gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens]          88   7e-18
gi|187608585 CASP8 and FADD-like apoptosis regulator isoform 2 [...    72   4e-13
gi|187608577 CASP8 and FADD-like apoptosis regulator isoform 1 [...    72   4e-13
gi|187608571 CASP8 and FADD-like apoptosis regulator isoform 1 [...    72   4e-13
gi|4505229 Fas-associated via death domain [Homo sapiens]              49   3e-06
gi|58530842 desmoplakin isoform II [Homo sapiens]                      42   5e-04
gi|4505705 phosphoprotein enriched in astrocytes 15 [Homo sapiens]     42   6e-04
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]     38   0.007
gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo s...    36   0.025
gi|50980301 myosin phosphatase-Rho interacting protein isoform 2...    34   0.095
gi|50980307 myosin phosphatase-Rho interacting protein isoform 1...    34   0.095
gi|45439327 periplakin [Homo sapiens]                                  34   0.12 
gi|239747793 PREDICTED: protein immuno-reactive with anti-PTH po...    33   0.21 
gi|239741673 PREDICTED: protein immuno-reactive with anti-PTH po...    33   0.21 
gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo s...    33   0.21 
gi|148596998 coiled-coil domain containing 122 [Homo sapiens]          33   0.21 
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    33   0.28 
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]                33   0.28 
gi|58530840 desmoplakin isoform I [Homo sapiens]                       32   0.36 
gi|52485606 formin-like 2 [Homo sapiens]                               32   0.47 
gi|150010604 kinesin family member 4B [Homo sapiens]                   32   0.62 
gi|89353287 death effector domain-containing protein [Homo sapiens]    32   0.62 

>gi|15718712 caspase 8 isoform E [Homo sapiens]
          Length = 235

 Score =  456 bits (1174), Expect = e-129
 Identities = 235/235 (100%), Positives = 235/235 (100%)

Query: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
           MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
Sbjct: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60

Query: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
           FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
Sbjct: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120

Query: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180
           KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
Sbjct: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180

Query: 181 FSKERSSSLEGSPDEFSNDFGQSLPNEKQTSGILSDHQQSQFCKSTGESAQTSQH 235
           FSKERSSSLEGSPDEFSNDFGQSLPNEKQTSGILSDHQQSQFCKSTGESAQTSQH
Sbjct: 181 FSKERSSSLEGSPDEFSNDFGQSLPNEKQTSGILSDHQQSQFCKSTGESAQTSQH 235


>gi|122056476 caspase 8 isoform G precursor [Homo sapiens]
          Length = 538

 Score =  382 bits (980), Expect = e-106
 Identities = 198/198 (100%), Positives = 198/198 (100%)

Query: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
           MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
Sbjct: 60  MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 119

Query: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
           FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
Sbjct: 120 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 179

Query: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180
           KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
Sbjct: 180 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 239

Query: 181 FSKERSSSLEGSPDEFSN 198
           FSKERSSSLEGSPDEFSN
Sbjct: 240 FSKERSSSLEGSPDEFSN 257


>gi|15718706 caspase 8 isoform B precursor [Homo sapiens]
          Length = 479

 Score =  382 bits (980), Expect = e-106
 Identities = 198/198 (100%), Positives = 198/198 (100%)

Query: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
           MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
Sbjct: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60

Query: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
           FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
Sbjct: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120

Query: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180
           KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
Sbjct: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180

Query: 181 FSKERSSSLEGSPDEFSN 198
           FSKERSSSLEGSPDEFSN
Sbjct: 181 FSKERSSSLEGSPDEFSN 198


>gi|122056474 caspase 8 isoform C precursor [Homo sapiens]
          Length = 464

 Score =  353 bits (905), Expect = 9e-98
 Identities = 183/183 (100%), Positives = 183/183 (100%)

Query: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
           MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
Sbjct: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60

Query: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
           FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
Sbjct: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120

Query: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180
           KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
Sbjct: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180

Query: 181 FSK 183
           FSK
Sbjct: 181 FSK 183


>gi|15718708 caspase 8 isoform C precursor [Homo sapiens]
          Length = 464

 Score =  353 bits (905), Expect = 9e-98
 Identities = 183/183 (100%), Positives = 183/183 (100%)

Query: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
           MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
Sbjct: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60

Query: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
           FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
Sbjct: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120

Query: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180
           KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
Sbjct: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180

Query: 181 FSK 183
           FSK
Sbjct: 181 FSK 183


>gi|15718704 caspase 8 isoform A precursor [Homo sapiens]
          Length = 496

 Score =  336 bits (862), Expect = 9e-93
 Identities = 183/215 (85%), Positives = 183/215 (85%), Gaps = 32/215 (14%)

Query: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
           MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
Sbjct: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60

Query: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAY------------------- 101
           FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAY                   
Sbjct: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRFHFCRMSWAEANSQCQTQ 120

Query: 102 -------------RVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEK 148
                        RVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEK
Sbjct: 121 SVPFWRRVDHLLIRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEK 180

Query: 149 RVILGEGKLDILKRVCAQINKSLLKIINDYEEFSK 183
           RVILGEGKLDILKRVCAQINKSLLKIINDYEEFSK
Sbjct: 181 RVILGEGKLDILKRVCAQINKSLLKIINDYEEFSK 215


>gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens]
          Length = 522

 Score = 87.8 bits (216), Expect = 7e-18
 Identities = 58/179 (32%), Positives = 94/179 (52%), Gaps = 7/179 (3%)

Query: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
           + F   L  I   L  +D+ +LKFL +  +P +K E    A  +F+ L  + +L E +  
Sbjct: 18  VSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPF 77

Query: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
           FL ELL+ I +  LL  +LN  KEE+ER L  P R ++S +R +LY++SE +    L+  
Sbjct: 78  FLAELLYIIRQKKLL-QHLNCTKEEVERLL--PTRQRVSLFRNLLYELSEGIDSENLKDM 134

Query: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYE 179
            FLL++ + K     +M  L     +EK+  + E  L  L+ +C  +   LL+ I  Y+
Sbjct: 135 IFLLKDSLPK----TEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNIEKYK 189


>gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens]
          Length = 521

 Score = 87.8 bits (216), Expect = 7e-18
 Identities = 58/179 (32%), Positives = 94/179 (52%), Gaps = 7/179 (3%)

Query: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
           + F   L  I   L  +D+ +LKFL +  +P +K E    A  +F+ L  + +L E +  
Sbjct: 18  VSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPF 77

Query: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
           FL ELL+ I +  LL  +LN  KEE+ER L  P R ++S +R +LY++SE +    L+  
Sbjct: 78  FLAELLYIIRQKKLL-QHLNCTKEEVERLL--PTRQRVSLFRNLLYELSEGIDSENLKDM 134

Query: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYE 179
            FLL++ + K     +M  L     +EK+  + E  L  L+ +C  +   LL+ I  Y+
Sbjct: 135 IFLLKDSLPK----TEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNIEKYK 189


>gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens]
          Length = 479

 Score = 87.8 bits (216), Expect = 7e-18
 Identities = 58/179 (32%), Positives = 94/179 (52%), Gaps = 7/179 (3%)

Query: 1   MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
           + F   L  I   L  +D+ +LKFL +  +P +K E    A  +F+ L  + +L E +  
Sbjct: 18  VSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPF 77

Query: 61  FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
           FL ELL+ I +  LL  +LN  KEE+ER L  P R ++S +R +LY++SE +    L+  
Sbjct: 78  FLAELLYIIRQKKLL-QHLNCTKEEVERLL--PTRQRVSLFRNLLYELSEGIDSENLKDM 134

Query: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYE 179
            FLL++ + K     +M  L     +EK+  + E  L  L+ +C  +   LL+ I  Y+
Sbjct: 135 IFLLKDSLPK----TEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNIEKYK 189


>gi|187608585 CASP8 and FADD-like apoptosis regulator isoform 2
           [Homo sapiens]
          Length = 221

 Score = 72.0 bits (175), Expect = 4e-13
 Identities = 51/193 (26%), Positives = 103/193 (53%), Gaps = 15/193 (7%)

Query: 7   LYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELL 66
           ++ + E LD+++   L FL  D         ++D L +   L+E+  L   +L+   ELL
Sbjct: 6   IHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDI---LRERGKLSVGDLA---ELL 59

Query: 67  FRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQE 126
           +R+ R DLL   L   ++ +E  L       +S YRV++ +I E++ +S++ S  FL+++
Sbjct: 60  YRVRRFDLLKRILKMDRKAVETHLLRNPHL-VSDYRVLMAEIGEDLDKSDVSSLIFLMKD 118

Query: 127 EISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKI-INDYEEFSKER 185
            + + K+  + + LD+ +E+EK  ++   +LD+L++    I++  LK  I  Y++     
Sbjct: 119 YMGRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQ----- 173

Query: 186 SSSLEGSPDEFSN 198
             S++G+   + N
Sbjct: 174 --SVQGAGTSYRN 184



 Score = 45.8 bits (107), Expect = 3e-05
 Identities = 32/122 (26%), Positives = 62/122 (50%), Gaps = 9/122 (7%)

Query: 2   DFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF 61
           D+   + +IGE LD  D++SL FL  DY+ + K    K  L L   L++  ++    L  
Sbjct: 92  DYRVLMAEIGEDLDKSDVSSLIFLMKDYMGRGKISKEKSFLDLVVELEKLNLVAPDQLDL 151

Query: 62  LKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFK 121
           L++ L  I+R+D     L T+ ++ ++ +Q  G    ++YR +L    ++  +    +F+
Sbjct: 152 LEKCLKNIHRID-----LKTKIQKYKQSVQGAG----TSYRNVLQAAIQKSLKDPSNNFR 202

Query: 122 FL 123
            +
Sbjct: 203 MI 204


>gi|187608577 CASP8 and FADD-like apoptosis regulator isoform 1
           [Homo sapiens]
          Length = 480

 Score = 72.0 bits (175), Expect = 4e-13
 Identities = 51/193 (26%), Positives = 103/193 (53%), Gaps = 15/193 (7%)

Query: 7   LYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELL 66
           ++ + E LD+++   L FL  D         ++D L +   L+E+  L   +L+   ELL
Sbjct: 6   IHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDI---LRERGKLSVGDLA---ELL 59

Query: 67  FRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQE 126
           +R+ R DLL   L   ++ +E  L       +S YRV++ +I E++ +S++ S  FL+++
Sbjct: 60  YRVRRFDLLKRILKMDRKAVETHLLRNPHL-VSDYRVLMAEIGEDLDKSDVSSLIFLMKD 118

Query: 127 EISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKI-INDYEEFSKER 185
            + + K+  + + LD+ +E+EK  ++   +LD+L++    I++  LK  I  Y++     
Sbjct: 119 YMGRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQ----- 173

Query: 186 SSSLEGSPDEFSN 198
             S++G+   + N
Sbjct: 174 --SVQGAGTSYRN 184



 Score = 45.1 bits (105), Expect = 5e-05
 Identities = 32/120 (26%), Positives = 61/120 (50%), Gaps = 9/120 (7%)

Query: 2   DFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF 61
           D+   + +IGE LD  D++SL FL  DY+ + K    K  L L   L++  ++    L  
Sbjct: 92  DYRVLMAEIGEDLDKSDVSSLIFLMKDYMGRGKISKEKSFLDLVVELEKLNLVAPDQLDL 151

Query: 62  LKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFK 121
           L++ L  I+R+D     L T+ ++ ++ +Q  G    ++YR +L    ++  +    +F+
Sbjct: 152 LEKCLKNIHRID-----LKTKIQKYKQSVQGAG----TSYRNVLQAAIQKSLKDPSNNFR 202


>gi|187608571 CASP8 and FADD-like apoptosis regulator isoform 1
           [Homo sapiens]
          Length = 480

 Score = 72.0 bits (175), Expect = 4e-13
 Identities = 51/193 (26%), Positives = 103/193 (53%), Gaps = 15/193 (7%)

Query: 7   LYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELL 66
           ++ + E LD+++   L FL  D         ++D L +   L+E+  L   +L+   ELL
Sbjct: 6   IHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDI---LRERGKLSVGDLA---ELL 59

Query: 67  FRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQE 126
           +R+ R DLL   L   ++ +E  L       +S YRV++ +I E++ +S++ S  FL+++
Sbjct: 60  YRVRRFDLLKRILKMDRKAVETHLLRNPHL-VSDYRVLMAEIGEDLDKSDVSSLIFLMKD 118

Query: 127 EISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKI-INDYEEFSKER 185
            + + K+  + + LD+ +E+EK  ++   +LD+L++    I++  LK  I  Y++     
Sbjct: 119 YMGRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQ----- 173

Query: 186 SSSLEGSPDEFSN 198
             S++G+   + N
Sbjct: 174 --SVQGAGTSYRN 184



 Score = 45.1 bits (105), Expect = 5e-05
 Identities = 32/120 (26%), Positives = 61/120 (50%), Gaps = 9/120 (7%)

Query: 2   DFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF 61
           D+   + +IGE LD  D++SL FL  DY+ + K    K  L L   L++  ++    L  
Sbjct: 92  DYRVLMAEIGEDLDKSDVSSLIFLMKDYMGRGKISKEKSFLDLVVELEKLNLVAPDQLDL 151

Query: 62  LKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFK 121
           L++ L  I+R+D     L T+ ++ ++ +Q  G    ++YR +L    ++  +    +F+
Sbjct: 152 LEKCLKNIHRID-----LKTKIQKYKQSVQGAG----TSYRNVLQAAIQKSLKDPSNNFR 202


>gi|4505229 Fas-associated via death domain [Homo sapiens]
          Length = 208

 Score = 49.3 bits (116), Expect = 3e-06
 Identities = 27/69 (39%), Positives = 38/69 (55%)

Query: 7  LYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELL 66
          L+ +   L S +L  LKFL L  + +RK E ++  L LF  L E+  LE  +   L+ELL
Sbjct: 8  LHSVSSSLSSSELTELKFLCLGRVGKRKLERVQSGLDLFSMLLEQNDLEPGHTELLRELL 67

Query: 67 FRINRLDLL 75
            + R DLL
Sbjct: 68 ASLRRHDLL 76



 Score = 42.7 bits (99), Expect = 3e-04
 Identities = 24/80 (30%), Positives = 46/80 (57%), Gaps = 1/80 (1%)

Query: 101 YRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDIL 160
           + V+L+ +S  +S SEL   KFL    + K KL+   + LD+F  + ++  L  G  ++L
Sbjct: 4   FLVLLHSVSSSLSSSELTELKFLCLGRVGKRKLERVQSGLDLFSMLLEQNDLEPGHTELL 63

Query: 161 KRVCAQINK-SLLKIINDYE 179
           + + A + +  LL+ ++D+E
Sbjct: 64  RELLASLRRHDLLRRVDDFE 83


>gi|58530842 desmoplakin isoform II [Homo sapiens]
          Length = 2272

 Score = 42.0 bits (97), Expect = 5e-04
 Identities = 41/159 (25%), Positives = 74/159 (46%), Gaps = 18/159 (11%)

Query: 45   FQRLQEKRMLEESNLSF--------LKELLFRINRLDLLITYLNTRKEEMERELQTPGRA 96
            + +LQ+ R  E+ NL +        +KE  + I RL +L+    TRK E E EL      
Sbjct: 1139 YDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASN- 1197

Query: 97   QISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILG--- 153
            +I   +    Q+ +E   S L   K L Q++    +L+D++N     +E E RV      
Sbjct: 1198 RIQESKNQCTQVVQE-RESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLEC 1256

Query: 154  -----EGKLDILKRVCAQINKSLLKIINDYEEFSKERSS 187
                 +  L+  K   ++  +++ KI ++ E+  +E++S
Sbjct: 1257 EKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS 1295


>gi|4505705 phosphoprotein enriched in astrocytes 15 [Homo sapiens]
          Length = 130

 Score = 41.6 bits (96), Expect = 6e-04
 Identities = 31/116 (26%), Positives = 50/116 (43%), Gaps = 6/116 (5%)

Query: 2   DFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF 61
           ++   L D+   +  EDL  LK    + IP  K E I      F  L+    L++ NLS+
Sbjct: 3   EYGTLLQDLTNNITLEDLEQLKSACKEDIPSEKSEEITTGSAWFSFLESHNKLDKDNLSY 62

Query: 62  LKELLFRINRLDLLITYLNTR------KEEMERELQTPGRAQISAYRVMLYQISEE 111
           ++ +     R DLL   ++ R       EE E + +         Y+ ++ Q SEE
Sbjct: 63  IEHIFEISRRPDLLTMVVDYRTRVLKISEEDELDTKLTRIPSAKKYKDIIRQPSEE 118


>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
          Length = 1979

 Score = 38.1 bits (87), Expect = 0.007
 Identities = 59/248 (23%), Positives = 98/248 (39%), Gaps = 32/248 (12%)

Query: 4   SRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRL----QEKRMLEESNL 59
           +RNL     QL+ E L  L         Q+K   I +     +++    +E + +  S+L
Sbjct: 749 ARNLNTSALQLEHEHLIKLN--------QKKDMEIAELKKNIEQMDTDHKETKDVLSSSL 800

Query: 60  SFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRS--EL 117
              K+L   IN+ ++ I  L  R  +++ EL     +Q      +L Q  EE  RS   +
Sbjct: 801 EEQKQLTQLINKKEIFIEKLKERSSKLQEELDK--YSQALRKNEILRQTIEEKDRSLGSM 858

Query: 118 RSFKFLLQEEISKCKLDD-------DMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKS 170
           +     LQEE+ + + +        D   LD   E+   V     +L+ +K    +  K 
Sbjct: 859 KEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEV----SQLNTIKEHLEEEIKH 914

Query: 171 LLKIINDYEEFSKERSSSLEGSP---DEFSNDFGQSLPNEKQTSGILSDHQQSQFCKSTG 227
             KII D  +   +   SL+      DEF     Q   N   T   L   ++ +  + T 
Sbjct: 915 HQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQM--NATHTQLFLEKDEEIKSLQKTI 972

Query: 228 ESAQTSQH 235
           E  +T  H
Sbjct: 973 EQIKTQLH 980



 Score = 28.5 bits (62), Expect = 5.2
 Identities = 24/105 (22%), Positives = 44/105 (41%), Gaps = 10/105 (9%)

Query: 82  RKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLD 141
           R EE+E  LQ  G   I      +Y++ + +   ++   +   + E  + K+ D      
Sbjct: 264 RIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKD------ 317

Query: 142 IFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKERS 186
               + K++   E   DIL+R   Q+N    +I+ + E    E S
Sbjct: 318 ----INKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECS 358


>gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo
           sapiens]
          Length = 1638

 Score = 36.2 bits (82), Expect = 0.025
 Identities = 49/213 (23%), Positives = 92/213 (43%), Gaps = 28/213 (13%)

Query: 16  SEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLL 75
           S+DL  +K L  +    RKQ  + ++  L Q+L+E   + +     L +   +I   +  
Sbjct: 484 SKDL-EIKNLKEEIEKLRKQ--VTESSHLEQQLEEANAVRQE----LDDAFRQIKAYEKQ 536

Query: 76  ITYLNTRKEEMER-ELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISK---- 130
           I  L   +E++ + E+ T   A  ++    L + SE  S+      + L Q++IS     
Sbjct: 537 IKTLQQEREDLNKLEVHTEALAAEASKDRKLREQSEHYSKQLENELEGLKQKQISYSPGV 596

Query: 131 CKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYE----------- 179
           C ++    +  +  ++EK+ I  E +L   + + A   K+L K ++D E           
Sbjct: 597 CSIEHQQEITKLKTDLEKKSIFYEEELSKREGIHANEIKNLKKELHDSEGQQLALNKEIM 656

Query: 180 ----EFSKERSSSLEGSPDEFSNDFGQSLPNEK 208
               +  K R  S +   +EF ++F Q    EK
Sbjct: 657 ILKDKLEKTRRES-QSEREEFESEFKQQYEREK 688


>gi|50980301 myosin phosphatase-Rho interacting protein isoform 2
           [Homo sapiens]
          Length = 1025

 Score = 34.3 bits (77), Expect = 0.095
 Identities = 31/101 (30%), Positives = 50/101 (49%), Gaps = 9/101 (8%)

Query: 35  QEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEEMERELQTPG 94
           Q+ I+D     QR  EK + EE +    +E    I+ ++ +    N  +EEMEREL+   
Sbjct: 736 QKKIEDLQRQHQRELEK-LREEKDRLLAEETAATISAIEAM---KNAHREEMERELEKSQ 791

Query: 95  RAQISA----YRVMLYQISEEVSRSELRSFKFLLQEEISKC 131
           R+QIS+       +  Q  EE+ +S  R  + L ++   KC
Sbjct: 792 RSQISSVNSDVEALRRQYLEEL-QSVQRELEVLSEQYSQKC 831


>gi|50980307 myosin phosphatase-Rho interacting protein isoform 1
           [Homo sapiens]
          Length = 1038

 Score = 34.3 bits (77), Expect = 0.095
 Identities = 31/101 (30%), Positives = 50/101 (49%), Gaps = 9/101 (8%)

Query: 35  QEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEEMERELQTPG 94
           Q+ I+D     QR  EK + EE +    +E    I+ ++ +    N  +EEMEREL+   
Sbjct: 736 QKKIEDLQRQHQRELEK-LREEKDRLLAEETAATISAIEAM---KNAHREEMERELEKSQ 791

Query: 95  RAQISA----YRVMLYQISEEVSRSELRSFKFLLQEEISKC 131
           R+QIS+       +  Q  EE+ +S  R  + L ++   KC
Sbjct: 792 RSQISSVNSDVEALRRQYLEEL-QSVQRELEVLSEQYSQKC 831


>gi|45439327 periplakin [Homo sapiens]
          Length = 1756

 Score = 33.9 bits (76), Expect = 0.12
 Identities = 31/117 (26%), Positives = 55/117 (47%), Gaps = 7/117 (5%)

Query: 62   LKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVM-----LYQISEEVSRSE 116
            + +L   + RL    T L  + EE+ERE Q    A+    R+      L Q   E     
Sbjct: 1382 IDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAEAREKV 1441

Query: 117  LRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLK 173
              + K +LQ++  + + +  +  L +  E  +R +L EG+L+ L+R  A + K+ +K
Sbjct: 1442 THTQKVVLQQDPQQAR-EHALLRLQLEEEQHRRQLL-EGELETLRRKLAALEKAEVK 1496


>gi|239747793 PREDICTED: protein immuno-reactive with anti-PTH
           polyclonal antibodies [Homo sapiens]
          Length = 868

 Score = 33.1 bits (74), Expect = 0.21
 Identities = 57/238 (23%), Positives = 96/238 (40%), Gaps = 41/238 (17%)

Query: 9   DIGEQLDSEDLASLKFL-SLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLF 67
           +I  QL  E L   K L SL +  Q++++  ++   L Q+++EK  + E           
Sbjct: 369 EIKSQLKHETLELEKELCSLRFAIQQEKKKRRNVEELHQKVREKLRITEEQY-------- 420

Query: 68  RINRLDLLITY-LNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQE 126
              R++  +T  +    +  E EL+T G            Q+SE   + +L     L+Q+
Sbjct: 421 ---RIEADVTKPIKPALKSAEVELKTGGNNS--------NQVSETDEKEDLLHENRLMQD 469

Query: 127 EISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKERS 186
           EI++ +L+ D         +EK+ +      +I+KR    + K+L +      E     S
Sbjct: 470 EIARLRLEKDTIKNQ---NLEKKYL---KDFEIVKRKHEDLQKALKRNEETLAETIACYS 523

Query: 187 SSLEGSPDEFS---------NDFGQSLPNEKQT-----SGILSDHQQSQFCKSTGESA 230
             L    DE +          + GQ L  E Q+     +  L DH QS   K   E A
Sbjct: 524 GQLAALTDENTTLRSKLEKQRESGQRLETEMQSYRCRLNAALCDHDQSHSSKRDQELA 581


>gi|239741673 PREDICTED: protein immuno-reactive with anti-PTH
            polyclonal antibodies [Homo sapiens]
          Length = 1430

 Score = 33.1 bits (74), Expect = 0.21
 Identities = 57/238 (23%), Positives = 96/238 (40%), Gaps = 41/238 (17%)

Query: 9    DIGEQLDSEDLASLKFL-SLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLF 67
            +I  QL  E L   K L SL +  Q++++  ++   L Q+++EK  + E           
Sbjct: 931  EIKSQLKHETLELEKELCSLRFAIQQEKKKRRNVEELHQKVREKLRITEEQY-------- 982

Query: 68   RINRLDLLITY-LNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQE 126
               R++  +T  +    +  E EL+T G            Q+SE   + +L     L+Q+
Sbjct: 983  ---RIEADVTKPIKPALKSAEVELKTGGNNS--------NQVSETDEKEDLLHENRLMQD 1031

Query: 127  EISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKERS 186
            EI++ +L+ D         +EK+ +      +I+KR    + K+L +      E     S
Sbjct: 1032 EIARLRLEKDTIKNQ---NLEKKYL---KDFEIVKRKHEDLQKALKRNEETLAETIACYS 1085

Query: 187  SSLEGSPDEFS---------NDFGQSLPNEKQT-----SGILSDHQQSQFCKSTGESA 230
              L    DE +          + GQ L  E Q+     +  L DH QS   K   E A
Sbjct: 1086 GQLAALTDENTTLRSKLEKQRESGQRLETEMQSYRCRLNAALCDHDQSHSSKRDQELA 1143


>gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo
           sapiens]
          Length = 1719

 Score = 33.1 bits (74), Expect = 0.21
 Identities = 34/147 (23%), Positives = 62/147 (42%), Gaps = 20/147 (13%)

Query: 81  TRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISK----CKLDDD 136
           T + + E E+ T   A  ++    L + SE  S+      + L Q++IS     C ++  
Sbjct: 624 TERAKKELEVHTEALAAEASKDRKLREQSEHYSKQLENELEGLKQKQISYSPGVCSIEHQ 683

Query: 137 MNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYE---------------EF 181
             +  +  ++EK+ I  E +L   + + A   K+L K ++D E               + 
Sbjct: 684 QEITKLKTDLEKKSIFYEEELSKREGIHANEIKNLKKELHDSEGQQLALNKEIMILKDKL 743

Query: 182 SKERSSSLEGSPDEFSNDFGQSLPNEK 208
            K R  S +   +EF ++F Q    EK
Sbjct: 744 EKTRRES-QSEREEFESEFKQQYEREK 769


>gi|148596998 coiled-coil domain containing 122 [Homo sapiens]
          Length = 273

 Score = 33.1 bits (74), Expect = 0.21
 Identities = 32/117 (27%), Positives = 59/117 (50%), Gaps = 19/117 (16%)

Query: 56  ESNLSFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRS 115
           ES  SF+ EL  + +     +  L T KEE+ ++LQ PG  +I+       Q+ E++  +
Sbjct: 143 ESKWSFMTELHEKRD----FVKKLKTMKEELMQDLQNPGGNRIT-------QVQEDI--T 189

Query: 116 ELRSFKFLLQEEI--SKCKLDDDMNLLDIFIEMEKRVILGEGKLD-ILKRVCAQINK 169
            L+     ++E I    C L+++    +   ++ K + +   + D ILKR+  Q+NK
Sbjct: 190 NLKDKIITVKESIIEKTCFLEEEKKTHE---KLRKEIEVQHKRYDAILKRLHCQVNK 243


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 32.7 bits (73), Expect = 0.28
 Identities = 52/221 (23%), Positives = 92/221 (41%), Gaps = 33/221 (14%)

Query: 15   DSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKR-MLEE--SNLSFLKELLFRINR 71
            D EDL S K    D + +   E  K    L Q+++E R  LEE    L   ++   R+  
Sbjct: 1512 DMEDLMSSK----DDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLE- 1566

Query: 72   LDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISE-EVSRSELRSFKFLLQEEISK 130
                   +   K + ER+LQT         R+++ Q+ E E    + R  + L     SK
Sbjct: 1567 -----VNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRAL--AVASK 1619

Query: 131  CKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKERSSSLE 190
             K++ D+  L             E +++   +   ++ K L K+    +++ +E   +  
Sbjct: 1620 KKMEIDLKDL-------------EAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEA-R 1665

Query: 191  GSPDEFSNDFGQSLPNEKQTSGILSDHQQSQFCKSTGESAQ 231
             S DE    F QS  +EK+   + ++  Q Q   ++ E A+
Sbjct: 1666 ASRDEI---FAQSKESEKKLKSLEAEILQLQEELASSERAR 1703



 Score = 31.6 bits (70), Expect = 0.62
 Identities = 39/158 (24%), Positives = 71/158 (44%), Gaps = 21/158 (13%)

Query: 6    NLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKEL 65
            ++ D+ EQLD E+ A  K        + K + +++ ++L         LE+ N  F+KE 
Sbjct: 951  HIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILL---------LEDQNSKFIKEK 1001

Query: 66   LFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQ 125
                +R+    + L   +EE  + L      Q     VM+  + E + + E    K   +
Sbjct: 1002 KLMEDRIAECSSQL-AEEEEKAKNLAKIRNKQ----EVMISDLEERLKKEE----KTRQE 1052

Query: 126  EEISKCKLD-DDMNLLDIFIEMEKRVILGEGKLDILKR 162
             E +K KLD +  +L D   E++ ++   E KL + K+
Sbjct: 1053 LEKAKRKLDGETTDLQDQIAELQAQI--DELKLQLAKK 1088



 Score = 28.5 bits (62), Expect = 5.2
 Identities = 26/98 (26%), Positives = 43/98 (43%), Gaps = 15/98 (15%)

Query: 56   ESNLSFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRS 115
            ES L   +ELL    R  L ++    + EE +  LQ               Q  EE +R 
Sbjct: 1314 ESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQ-------------QEEEEEARK 1360

Query: 116  ELRSFKFLLQEEIS--KCKLDDDMNLLDIFIEMEKRVI 151
             L      LQ +++  K K+DDD+  ++   E +K+++
Sbjct: 1361 NLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLL 1398


>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
          Length = 2017

 Score = 32.7 bits (73), Expect = 0.28
 Identities = 30/120 (25%), Positives = 54/120 (45%), Gaps = 15/120 (12%)

Query: 32   QRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEEMERELQ 91
            +++QE    AL   Q+LQ++R L +  L  L+  L            L   K E+ER   
Sbjct: 1820 RQRQEGEAAALNTVQKLQDERRLLQERLGSLQRAL----------AQLEAEKREVER--- 1866

Query: 92   TPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVI 151
                 ++   RV L +  ++V R +LRS +  ++    K +LD  +   ++ +   +R I
Sbjct: 1867 --SALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQI 1924



 Score = 28.9 bits (63), Expect = 4.0
 Identities = 39/172 (22%), Positives = 73/172 (42%), Gaps = 12/172 (6%)

Query: 28  DYIPQRKQEPIKDALMLFQRLQEK-RMLE--ESNLSFLKELLFRI----NRLDLLITYLN 80
           D + + +++ ++D   + + L+   R LE  E   S L + L  +    +R  L    L 
Sbjct: 641 DRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQ 700

Query: 81  TRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLL 140
             K E+   L      ++     M    +EE S  +  S    L E +++ KL  D+N L
Sbjct: 701 AEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKL--DLNRL 758

Query: 141 DIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKERSSSLEGS 192
              +E EK  + G  +    +   A+  +  L+ +   +E +++    LEGS
Sbjct: 759 VAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQ---GLEGS 807


>gi|58530840 desmoplakin isoform I [Homo sapiens]
          Length = 2871

 Score = 32.3 bits (72), Expect = 0.36
 Identities = 30/106 (28%), Positives = 49/106 (46%), Gaps = 20/106 (18%)

Query: 45   FQRLQEKRMLEESNLSF--------LKELLFRINRLDLLITYLNTRKEEMEREL---QTP 93
            + +LQ+ R  E+ NL +        +KE  + I RL +L+    TRK E E EL   +  
Sbjct: 1139 YDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNH 1198

Query: 94   GRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNL 139
               ++S  R   Y+    ++++ ++        EIS  K DD  NL
Sbjct: 1199 YNEEMSNLR-NKYETEINITKTTIK--------EISMQKEDDSKNL 1235


>gi|52485606 formin-like 2 [Homo sapiens]
          Length = 1092

 Score = 32.0 bits (71), Expect = 0.47
 Identities = 34/143 (23%), Positives = 68/143 (47%), Gaps = 16/143 (11%)

Query: 58  NLSFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSEL 117
           +++F   L +   +L L   YL+  K     +LQ     QI AY   ++ +   +  +E 
Sbjct: 333 DMNFRVHLQYEFTKLGL-DEYLDKLKHTESDKLQV----QIQAYLDNVFDVGALLEDAET 387

Query: 118 RSFKFLLQEEISKC------KLDDDMN-LLDIFIEMEKRVILGEGKLDILKRVCAQIN-- 168
           ++      EE+ +       KL D  N  +   +E+EK+++    +LD+++ +    N  
Sbjct: 388 KNAALERVEELEENISHLSEKLQDTENEAMSKIVELEKQLMQRNKELDVVREIYKDANTQ 447

Query: 169 -KSLLKIINDYEEFSKERSSSLE 190
             +L K++ + EE + +R S+LE
Sbjct: 448 VHTLRKMVKEKEE-AIQRQSTLE 469


>gi|150010604 kinesin family member 4B [Homo sapiens]
          Length = 1234

 Score = 31.6 bits (70), Expect = 0.62
 Identities = 33/115 (28%), Positives = 47/115 (40%), Gaps = 27/115 (23%)

Query: 44  LFQRLQEKRMLEESNLSFLKELLFR-------------------INRLDLLITYLNTRKE 84
           L Q    K ++E +N   LKE L R                   I  L+L +  L   KE
Sbjct: 517 LHQAQMSKEVVELNNALALKEALVRKMTQNDNQLQPIQFQYQDNIKNLELEVINLQKEKE 576

Query: 85  EMERELQTP----GRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDD 135
           E+ RELQT      +A++S +R  L Q  E     ++   K  L E+    KL +
Sbjct: 577 ELVRELQTAKKNVNQAKLSEHRHKLLQELE----GQIADLKKKLNEQSKLLKLKE 627


>gi|89353287 death effector domain-containing protein [Homo
          sapiens]
          Length = 318

 Score = 31.6 bits (70), Expect = 0.62
 Identities = 20/66 (30%), Positives = 32/66 (48%)

Query: 10 IGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRI 69
          +G  L   D+  L FL +D I   ++  I++       L+ +   +ESN   + +LL  I
Sbjct: 33 VGTHLTHRDVRVLSFLFVDVIDDHERGLIRNGRDFLLALERQGRCDESNFRQVLQLLRII 92

Query: 70 NRLDLL 75
           R DLL
Sbjct: 93 TRHDLL 98


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.134    0.357 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 7,882,914
Number of Sequences: 37866
Number of extensions: 330920
Number of successful extensions: 1307
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 57
Number of HSP's that attempted gapping in prelim test: 1234
Number of HSP's gapped (non-prelim): 105
length of query: 235
length of database: 18,247,518
effective HSP length: 99
effective length of query: 136
effective length of database: 14,498,784
effective search space: 1971834624
effective search space used: 1971834624
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 60 (27.7 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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