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Search of human proteins with 15718680
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
(620 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens] 1284 0.0
gi|130977759 tec protein tyrosine kinase [Homo sapiens] 758 0.0
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens] 648 0.0
gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens] 565 e-161
gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens] 565 e-161
gi|148596974 TXK tyrosine kinase [Homo sapiens] 561 e-160
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is... 317 2e-86
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 317 3e-86
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 316 4e-86
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 316 4e-86
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens] 314 1e-85
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] 310 2e-84
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 309 4e-84
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 309 4e-84
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ... 309 4e-84
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 309 6e-84
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 305 6e-83
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 305 6e-83
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens] 305 6e-83
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 305 1e-82
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 305 1e-82
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 305 1e-82
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 305 1e-82
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 305 1e-82
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 305 1e-82
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 305 1e-82
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi... 305 1e-82
gi|4503787 fyn-related kinase [Homo sapiens] 296 3e-80
gi|18250298 src-related kinase lacking C-terminal regulatory tyr... 273 3e-73
gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens] 270 3e-72
>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
Length = 620
Score = 1284 bits (3322), Expect = 0.0
Identities = 620/620 (100%), Positives = 620/620 (100%)
Query: 1 MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRI 60
MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRI
Sbjct: 1 MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRI 60
Query: 61 KCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKY 120
KCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKY
Sbjct: 61 KCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKY 120
Query: 121 HPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALY 180
HPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALY
Sbjct: 121 HPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALY 180
Query: 181 DYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWY 240
DYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWY
Sbjct: 181 DYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWY 240
Query: 241 NKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETND 300
NKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETND
Sbjct: 241 NKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETND 300
Query: 301 NPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDP 360
NPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDP
Sbjct: 301 NPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDP 360
Query: 361 SELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQ 420
SELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQ
Sbjct: 361 SELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQ 420
Query: 421 LYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIH 480
LYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIH
Sbjct: 421 LYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIH 480
Query: 481 RDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSD 540
RDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSD
Sbjct: 481 RDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSD 540
Query: 541 VWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPE 600
VWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPE
Sbjct: 541 VWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPE 600
Query: 601 DRPAFSRLLRQLAEIAESGL 620
DRPAFSRLLRQLAEIAESGL
Sbjct: 601 DRPAFSRLLRQLAEIAESGL 620
>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
Length = 631
Score = 758 bits (1956), Expect = 0.0
Identities = 366/626 (58%), Positives = 469/626 (74%), Gaps = 11/626 (1%)
Query: 1 MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRI 60
MN +LEE LIK+SQQK++TSP N+K R FVLTK+ L Y+E R +K+ KG I++S+I
Sbjct: 1 MNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYEGR-AEKKYRKGFIDVSKI 59
Query: 61 KCVEIVKSDIS-IPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPK 119
KCVEIVK+D IPC KYPFQVVHD LY+FAP +SR WV LKEE +NNN+++ K
Sbjct: 60 KCVEIVKNDDGVIPCQNKYPFQVVHDANTLYIFAPSPQSRDLWVKKLKEEIKNNNNIMIK 119
Query: 120 YHPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRR------PLWEPE- 172
YHP FW DG ++CC Q EKLA GC +Y+ +++ +K LPP PE +R PL E +
Sbjct: 120 YHPKFWTDGSYQCCRQTEKLAPGCEKYNLFESSIRKALPPAPETKKRRPPPPIPLEEEDN 179
Query: 173 -ETVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSP 231
E +V+A+YD+Q + +L L R +EY +L+ +++HWWR +D+ G+EGY+PS+Y+ K
Sbjct: 180 SEEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARDKYGNEGYIPSNYVTGKKS 239
Query: 232 NNLETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIK 291
NNL+ YEWY ++++R KAE+LL KEG FMVRDS G YTVS++TK E + +
Sbjct: 240 NNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQPGLYTVSLYTK-FGGEGSSGFR 298
Query: 292 HYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGL 351
HYHIKET +PK+YY+AEK+ F SIP +I YH+HN GLVTRLRYPV + AP TAG
Sbjct: 299 HYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGF 358
Query: 352 RYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMM 411
Y KW I+PSELTF++E+GSG FG+V LG W + KVAIK IREGAM EEDFIEEA+VMM
Sbjct: 359 SYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMM 418
Query: 412 KLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMA 471
KL+HPKLVQLYGVC +Q PI +V EFME GCL ++LR ++G F+ + LL MC DVCEGM
Sbjct: 419 KLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGME 478
Query: 472 YLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFS 531
YLE IHRDLAARNCLV E V+KVSDFGM R+VLDDQYTSS+G KFPVKW PEVF+
Sbjct: 479 YLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFN 538
Query: 532 FSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIM 591
+SR+SSKSDVWSFGVLMWEVF+EG++P+E +N EVV ++ G RLY+P+LAS +VY++M
Sbjct: 539 YSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVM 598
Query: 592 NHCWKERPEDRPAFSRLLRQLAEIAE 617
CW+E+PE RP+F LLR + E+ E
Sbjct: 599 LRCWQEKPEGRPSFEDLLRTIDELVE 624
>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
Length = 659
Score = 648 bits (1671), Expect = 0.0
Identities = 327/658 (49%), Positives = 441/658 (67%), Gaps = 50/658 (7%)
Query: 5 ILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFED--RHGKKRTLKGSIELSRIKC 62
++LE +K+SQQK++TSP NFK R F+LT L+Y+E G++ + KGSI++ +I C
Sbjct: 4 VILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITC 63
Query: 63 VEIVKSD---------------------ISIPCHYKYPFQVVHDNYLLYVFAPDRESRQR 101
VE V + ISI + YPFQVV+D LYVF+P E R+R
Sbjct: 64 VETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKR 123
Query: 102 WVLALKEETRNNNSLVPKYHPNFWMDGKWRCCSQLEKLATGCAQYDPTKNAS-------- 153
W+ LK R N+ LV KYHP FW+DG++ CCSQ K A GC Q +N S
Sbjct: 124 WIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGC-QILENRNGSLKPGSSHR 182
Query: 154 --KKPLPPTPEDNR------------RPLWEPEETVVIALYDYQTNDPQELALRRNEEYC 199
KKPLPPTPE+++ P+ E V+ALYDY + +L LR+ +EY
Sbjct: 183 KTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYF 242
Query: 200 LLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKE 259
+L+ S + WWR +D+NG EGY+PS+Y+ E + +++E YEWY+K ++R +AE+LL GKE
Sbjct: 243 ILEESNLPWWRARDKNGQEGYIPSNYVTE-AEDSIEMYEWYSKHMTRSQAEQLLKQEGKE 301
Query: 260 GAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLL 319
G F+VRDS AG YTVSVF K+ + I+HY + T + +YY+AEK++F +IP L
Sbjct: 302 GGFIVRDSSKAGKYTVSVFAKST-GDPQGVIRHYVVCSTPQS--QYYLAEKHLFSTIPEL 358
Query: 320 INYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDPSELTFVQEIGSGQFGLVHL 379
INYHQHN GL++RL+YPV + AP TAGL YG W IDP +LTF++E+G+GQFG+V
Sbjct: 359 INYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKY 418
Query: 380 GYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFME 439
G W + VAIK I+EG+MSE++FIEEA+VMM LSH KLVQLYGVC +Q PI ++ E+M
Sbjct: 419 GKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMA 478
Query: 440 HGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVS 499
+GCL +YLR R F + LL MC DVCE M YLE +HRDLAARNCLV + V+KVS
Sbjct: 479 NGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVS 538
Query: 500 DFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPY 559
DFG++R+VLDD+YTSS G+KFPV+W+ PEV +S++SSKSD+W+FGVLMWE++S GK+PY
Sbjct: 539 DFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPY 598
Query: 560 ENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIAE 617
E +NSE E I+ G RLY+P LAS VY IM CW E+ ++RP F LL + ++ +
Sbjct: 599 ERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMD 656
>gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens]
Length = 675
Score = 565 bits (1456), Expect = e-161
Identities = 302/674 (44%), Positives = 413/674 (61%), Gaps = 60/674 (8%)
Query: 1 MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRI 60
M+ +LEE L+K+SQQK++ SP+N+K R FVLTK +L+Y+E K+ + KGSIE+ +I
Sbjct: 1 MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKI 60
Query: 61 KCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKY 120
+CVE V + P +YPFQ+V+ + LLYV+A + ESR +W+ AL++E R N L+ KY
Sbjct: 61 RCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVKY 120
Query: 121 HPNFWMDGKWRCCSQLEKLATGCAQYDP------TKNASKKPLPPTPEDNRR-------- 166
H F++DGK+ CC Q K A GC ++ N K +P P+ +
Sbjct: 121 HSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPDRVLKIPRAVPVL 180
Query: 167 PLWEPEETVVIALYD--------------------YQTNDPQELALRRNEEYCLLDSSEI 206
+ P + +A YD Y +N + + N + +
Sbjct: 181 KMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPREDF 240
Query: 207 -HWWRVQDRNGHEGY--VPSSYLVEKSPN--------------------NLETYEWYNKS 243
WW+V+ V SS E++ N NL+ Y+W+ +
Sbjct: 241 PDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGN 300
Query: 244 ISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETNDNPK 303
ISR ++E+LL GKEGAFMVR+S G YTVS+F+KAV ++ +KHYH+ +N
Sbjct: 301 ISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAV-NDKKGTVKHYHVHTNAEN-- 357
Query: 304 RYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDPSEL 363
+ Y+AE Y FDSIP LI+YHQHN G++TRLR+PV K P + L G W + E+
Sbjct: 358 KLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEI 417
Query: 364 TFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYG 423
T ++E+GSGQFG+V LG W + VA+K I+EG+MSE++F +EA+ MMKLSHPKLV+ YG
Sbjct: 418 TLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYG 477
Query: 424 VCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDL 483
VC ++ PI +V E++ +GCL +YLR+ LL MC DVCEGMA+LE IHRDL
Sbjct: 478 VCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDL 537
Query: 484 AARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWS 543
AARNCLV + +KVSDFGMTR+VLDDQY SS GTKFPVKW++PEVF + +YSSKSDVW+
Sbjct: 538 AARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWA 597
Query: 544 FGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRP 603
FG+LMWEVFS GK PY+ NS+VV +S G RLY+P LAS +YQIM CW E PE RP
Sbjct: 598 FGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRP 657
Query: 604 AFSRLLRQLAEIAE 617
F +LL + + E
Sbjct: 658 TFQQLLSSIEPLRE 671
>gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens]
Length = 675
Score = 565 bits (1456), Expect = e-161
Identities = 302/674 (44%), Positives = 413/674 (61%), Gaps = 60/674 (8%)
Query: 1 MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRI 60
M+ +LEE L+K+SQQK++ SP+N+K R FVLTK +L+Y+E K+ + KGSIE+ +I
Sbjct: 1 MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKI 60
Query: 61 KCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKY 120
+CVE V + P +YPFQ+V+ + LLYV+A + ESR +W+ AL++E R N L+ KY
Sbjct: 61 RCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVKY 120
Query: 121 HPNFWMDGKWRCCSQLEKLATGCAQYDP------TKNASKKPLPPTPEDNRR-------- 166
H F++DGK+ CC Q K A GC ++ N K +P P+ +
Sbjct: 121 HSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPDRVLKIPRAVPVL 180
Query: 167 PLWEPEETVVIALYD--------------------YQTNDPQELALRRNEEYCLLDSSEI 206
+ P + +A YD Y +N + + N + +
Sbjct: 181 KMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPREDF 240
Query: 207 -HWWRVQDRNGHEGY--VPSSYLVEKSPN--------------------NLETYEWYNKS 243
WW+V+ V SS E++ N NL+ Y+W+ +
Sbjct: 241 PDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGN 300
Query: 244 ISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETNDNPK 303
ISR ++E+LL GKEGAFMVR+S G YTVS+F+KAV ++ +KHYH+ +N
Sbjct: 301 ISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAV-NDKKGTVKHYHVHTNAEN-- 357
Query: 304 RYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDPSEL 363
+ Y+AE Y FDSIP LI+YHQHN G++TRLR+PV K P + L G W + E+
Sbjct: 358 KLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEI 417
Query: 364 TFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYG 423
T ++E+GSGQFG+V LG W + VA+K I+EG+MSE++F +EA+ MMKLSHPKLV+ YG
Sbjct: 418 TLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYG 477
Query: 424 VCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDL 483
VC ++ PI +V E++ +GCL +YLR+ LL MC DVCEGMA+LE IHRDL
Sbjct: 478 VCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDL 537
Query: 484 AARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWS 543
AARNCLV + +KVSDFGMTR+VLDDQY SS GTKFPVKW++PEVF + +YSSKSDVW+
Sbjct: 538 AARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWA 597
Query: 544 FGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRP 603
FG+LMWEVFS GK PY+ NS+VV +S G RLY+P LAS +YQIM CW E PE RP
Sbjct: 598 FGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRP 657
Query: 604 AFSRLLRQLAEIAE 617
F +LL + + E
Sbjct: 658 TFQQLLSSIEPLRE 671
>gi|148596974 TXK tyrosine kinase [Homo sapiens]
Length = 527
Score = 561 bits (1446), Expect = e-160
Identities = 281/487 (57%), Positives = 352/487 (72%), Gaps = 13/487 (2%)
Query: 134 SQLE-KLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVI-ALYDYQTNDPQELA 191
SQL K + + P+K +KPLPP P P EE + + ALYD+ +P LA
Sbjct: 51 SQLSNKKQSNTGRVQPSK---RKPLPPLP-----PSEVAEEKIQVKALYDFLPREPCNLA 102
Query: 192 LRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEK 251
LRR EEY +L+ HWW+ +DR G+EG +PS+Y+ E NLE YEWY+++I+R++AE
Sbjct: 103 LRRAEEYLILEKYNPHWWKARDRLGNEGLIPSNYVTENKITNLEIYEWYHRNITRNQAEH 162
Query: 252 LLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKY 311
LL KEGAF+VRDSR G+YT+SVF A S IKHY IK+ + ++YVAE++
Sbjct: 163 LLRQESKEGAFIVRDSRHLGSYTISVFMGARRS-TEAAIKHYQIKKNDSG--QWYVAERH 219
Query: 312 VFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDPSELTFVQEIGS 371
F SIP LI YHQHN GL+TRLRYPV P TAG Y KW IDPSEL F++EIGS
Sbjct: 220 AFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGS 279
Query: 372 GQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPI 431
GQFG+VHLG W + +VAIK I EG+MSEEDFIEEA+VMMKLSH KLVQLYGVC+++ P+
Sbjct: 280 GQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPL 339
Query: 432 CLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVG 491
+V EFME+GCL +YLR +G E LL +C D+CEGM YLE IHRDLAARNCLV
Sbjct: 340 YIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVS 399
Query: 492 ENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEV 551
++K+SDFGMTR+VLDD+Y SS G KFP+KW+ PEVF F++YSSKSDVWSFGVLMWEV
Sbjct: 400 STCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEV 459
Query: 552 FSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQ 611
F+EGK+P+EN+SN +VVE IS GFRLY+P LA +Y++M CW E+PE RP F+ LLR
Sbjct: 460 FTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRA 519
Query: 612 LAEIAES 618
+ EIAE+
Sbjct: 520 VTEIAET 526
>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform A [Homo sapiens]
Length = 512
Score = 317 bits (812), Expect = 2e-86
Identities = 177/473 (37%), Positives = 274/473 (57%), Gaps = 25/473 (5%)
Query: 147 DPTKNASKKPLPPTP--EDNRRPLWEPEET--VVIALYDYQTNDPQELALRRNEEYCLLD 202
DPT N ++P+P + R +PEE +V+ALY Y P +L+ ++ E+ +L+
Sbjct: 35 DPTSNKQQRPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLE 94
Query: 203 SSEIHWWRVQDR-NGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKE-G 260
WW+ + EG++PS+Y+ + N LET EW+ K I+R AE+ LL G G
Sbjct: 95 EHG-EWWKAKSLLTKKEGFIPSNYVAKL--NTLETEEWFFKDITRKDAERQLLAPGNSAG 151
Query: 261 AFMVRDSRTA-GTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLL 319
AF++R+S T G++++SV V + IKHY I+ ++ YY++ + F I +
Sbjct: 152 AFLIRESETLKGSFSLSVRDFDPV--HGDVIKHYKIRSLDNGG--YYISPRITFPCISDM 207
Query: 320 INYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDPSELTFVQEIGSGQFGLVHL 379
I ++Q GL RL + + P W I + V+ +G+GQFG V +
Sbjct: 208 IKHYQKQADGLCRRLEKACISPKPQKPWDKDA----WEIPRESIKLVKRLGAGQFGEVWM 263
Query: 380 GYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFME 439
GY+ N KVA+KT++ G MS + F+EEA +M L H KLV+LY V + PI ++ E+M
Sbjct: 264 GYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMA 323
Query: 440 HGCLSDYLRTQRGLFAAETLLGMCLD----VCEGMAYLEEACVIHRDLAARNCLVGENQV 495
G L D+L++ G + LL +D + EGMAY+E IHRDL A N LV E+ +
Sbjct: 324 KGSLLDFLKSDEG---GKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLM 380
Query: 496 IKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEG 555
K++DFG+ R + D++YT+ G KFP+KW +PE +F ++ KSDVWSFG+L++E+ + G
Sbjct: 381 CKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYG 440
Query: 556 KIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRL 608
KIPY R+N++V+ +S G+R+ + +Y IM CWKE+ E+RP F L
Sbjct: 441 KIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYL 493
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 317 bits (811), Expect = 3e-86
Identities = 163/439 (37%), Positives = 257/439 (58%), Gaps = 11/439 (2%)
Query: 174 TVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQD-RNGHEGYVPSSYLVEKSPN 232
T+ +ALYDY+ +L+ + E++ +L+SSE WW + G GY+PS+Y+ +
Sbjct: 85 TLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPV--D 142
Query: 233 NLETYEWYNKSISRDKAEKLLLDTGK-EGAFMVRDSRTA-GTYTVSVFTKAVVSENNPCI 290
+++ EWY + R AE+ LL G G F++R+S T G Y++S+ + ++ +
Sbjct: 143 SIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDH--V 200
Query: 291 KHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAG 350
KHY I++ ++ YY+ + F+++ L+ ++ GL RL P G + +
Sbjct: 201 KHYKIRKLDNGG--YYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSV 258
Query: 351 LRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVM 410
W I L ++ +G+GQFG V +G W KVAIKT++ G MS E F+EEA++M
Sbjct: 259 KTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIM 318
Query: 411 MKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRG-LFAAETLLGMCLDVCEG 469
KL H KLVQLY V E+ PI +V E+M G L D+L+ G L+ M V G
Sbjct: 319 KKLKHDKLVQLYAVVSEE-PIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAG 377
Query: 470 MAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEV 529
MAY+E IHRDL + N LVG + K++DFG+ R + D++YT+ G KFP+KW +PE
Sbjct: 378 MAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEA 437
Query: 530 FSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQ 589
+ R++ KSDVWSFG+L+ E+ ++G++PY +N EV+E + G+R+ P+ +++
Sbjct: 438 ALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHE 497
Query: 590 IMNHCWKERPEDRPAFSRL 608
+M HCWK+ PE+RP F L
Sbjct: 498 LMIHCWKKDPEERPTFEYL 516
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 316 bits (810), Expect = 4e-86
Identities = 164/453 (36%), Positives = 271/453 (59%), Gaps = 16/453 (3%)
Query: 160 TPEDNRRPLWEPEETVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQD-RNGHE 218
T E + P ++ +VIAL+ Y+ + +L + E+ +L+ S WW+ Q G E
Sbjct: 50 TYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSG-EWWKAQSLTTGQE 108
Query: 219 GYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGK-EGAFMVRDSR-TAGTYTVS 276
G++P +++ + N+LE W+ K++SR AE+ LL G G+F++R+S TAG++++S
Sbjct: 109 GFIPFNFVAKA--NSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLS 166
Query: 277 VFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRY 336
V + +KHY I+ ++ +Y++ + F + L+ ++ + GL TRL
Sbjct: 167 V--RDFDQNQGEVVKHYKIRNLDNGG--FYISPRITFPGLHELVRHYTNASDGLCTRLSR 222
Query: 337 PVCFGRQKAPVTAGLRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREG 396
P + + P +W + L V+ +G+GQFG V +GY+ KVA+K++++G
Sbjct: 223 PCQTQKPQKPWWED----EWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQG 278
Query: 397 AMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGL-FA 455
+MS + F+ EA +M +L H +LV+LY V + Q PI ++ E+ME+G L D+L+T G+
Sbjct: 279 SMSPDAFLAEANLMKQLQHQRLVRLYAV-VTQEPIYIITEYMENGSLVDFLKTPSGIKLT 337
Query: 456 AETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSS 515
LL M + EGMA++EE IHRDL A N LV + K++DFG+ R + D++YT+
Sbjct: 338 INKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAR 397
Query: 516 TGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGF 575
G KFP+KW +PE ++ ++ KSDVWSFG+L+ E+ + G+IPY +N EV++++ G+
Sbjct: 398 EGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGY 457
Query: 576 RLYKPRLASTHVYQIMNHCWKERPEDRPAFSRL 608
R+ +P +YQ+M CWKERPEDRP F L
Sbjct: 458 RMVRPDNCPEELYQLMRLCWKERPEDRPTFDYL 490
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 316 bits (810), Expect = 4e-86
Identities = 164/453 (36%), Positives = 271/453 (59%), Gaps = 16/453 (3%)
Query: 160 TPEDNRRPLWEPEETVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQD-RNGHE 218
T E + P ++ +VIAL+ Y+ + +L + E+ +L+ S WW+ Q G E
Sbjct: 50 TYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSG-EWWKAQSLTTGQE 108
Query: 219 GYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGK-EGAFMVRDSR-TAGTYTVS 276
G++P +++ + N+LE W+ K++SR AE+ LL G G+F++R+S TAG++++S
Sbjct: 109 GFIPFNFVAKA--NSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLS 166
Query: 277 VFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRY 336
V + +KHY I+ ++ +Y++ + F + L+ ++ + GL TRL
Sbjct: 167 V--RDFDQNQGEVVKHYKIRNLDNGG--FYISPRITFPGLHELVRHYTNASDGLCTRLSR 222
Query: 337 PVCFGRQKAPVTAGLRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREG 396
P + + P +W + L V+ +G+GQFG V +GY+ KVA+K++++G
Sbjct: 223 PCQTQKPQKPWWED----EWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQG 278
Query: 397 AMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGL-FA 455
+MS + F+ EA +M +L H +LV+LY V + Q PI ++ E+ME+G L D+L+T G+
Sbjct: 279 SMSPDAFLAEANLMKQLQHQRLVRLYAV-VTQEPIYIITEYMENGSLVDFLKTPSGIKLT 337
Query: 456 AETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSS 515
LL M + EGMA++EE IHRDL A N LV + K++DFG+ R + D++YT+
Sbjct: 338 INKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAR 397
Query: 516 TGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGF 575
G KFP+KW +PE ++ ++ KSDVWSFG+L+ E+ + G+IPY +N EV++++ G+
Sbjct: 398 EGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGY 457
Query: 576 RLYKPRLASTHVYQIMNHCWKERPEDRPAFSRL 608
R+ +P +YQ+M CWKERPEDRP F L
Sbjct: 458 RMVRPDNCPEELYQLMRLCWKERPEDRPTFDYL 490
>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
Length = 543
Score = 314 bits (805), Expect = 1e-85
Identities = 165/436 (37%), Positives = 260/436 (59%), Gaps = 14/436 (3%)
Query: 174 TVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQD-RNGHEGYVPSSYLVEKSPN 232
T+ +ALYDY+ ++L+ ++ E + +++++E WW + G GY+PS+Y+ +
Sbjct: 94 TIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPA--D 151
Query: 233 NLETYEWYNKSISRDKAEKLLLDTGKE-GAFMVRDSRTA-GTYTVSVFTKAVVSENNPCI 290
+++ EWY + R AE+LLL+ G + G F+VR+S T G Y++S+ + +N +
Sbjct: 152 SIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDN--V 209
Query: 291 KHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAG 350
KHY I++ ++ YY+ + FD++ L+ ++ + GL +L VC P T G
Sbjct: 210 KHYKIRKLDNGG--YYITTRAQFDTLQKLVKHYTEHADGLCHKLT-TVC--PTVKPQTQG 264
Query: 351 LRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVM 410
L W I L ++G G FG V +G W KVAIKT++ G M E F++EA++M
Sbjct: 265 LAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIM 324
Query: 411 MKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAA-ETLLGMCLDVCEG 469
KL H KLV LY V E+ PI +V EFM G L D+L+ G + L+ M + +G
Sbjct: 325 KKLRHDKLVPLYAVVSEE-PIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADG 383
Query: 470 MAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEV 529
MAY+E IHRDL A N LVGEN V K++DFG+ R + D++YT+ G KFP+KW +PE
Sbjct: 384 MAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEA 443
Query: 530 FSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQ 589
+ R++ KSDVWSFG+L E+ ++G++PY N EV+E + G+R+ P+ +++
Sbjct: 444 ALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHE 503
Query: 590 IMNHCWKERPEDRPAF 605
+MN CWK+ P++RP F
Sbjct: 504 LMNLCWKKDPDERPTF 519
>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
Length = 534
Score = 310 bits (795), Expect = 2e-84
Identities = 162/439 (36%), Positives = 254/439 (57%), Gaps = 14/439 (3%)
Query: 174 TVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQD-RNGHEGYVPSSYLVEKSPN 232
T+ +ALYDY+ +L+ + E++ +L+SSE WW + G GY+PS+Y+ +
Sbjct: 85 TLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPV--D 142
Query: 233 NLETYEWYNKSISRDKAEKLLLDTGK-EGAFMVRDSRTA-GTYTVSVFTKAVVSENNPCI 290
+++ EWY + R AE+ LL G G F++R+S T G Y++S+ + ++ +
Sbjct: 143 SIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDH--V 200
Query: 291 KHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAG 350
KHY I++ ++ YY+ + F+++ L+ ++ GL L P T+G
Sbjct: 201 KHYKIRKLDNGG--YYITTRAQFETLQQLVQHYSEKADGLCFNL---TVIASSCTPQTSG 255
Query: 351 LRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVM 410
L W + L +++G G F V LG W KVAIKT++ G MS E F+EEA++M
Sbjct: 256 LAKDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPESFLEEAQIM 315
Query: 411 MKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRG-LFAAETLLGMCLDVCEG 469
KL H KLVQLY V E+ PI +V E+M G L D+L+ G L+ M V G
Sbjct: 316 KKLKHDKLVQLYAVVSEE-PIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAG 374
Query: 470 MAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEV 529
MAY+E IHRDL + N LVG + K++DFG+ R + D++YT+ G KFP+KW +PE
Sbjct: 375 MAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEA 434
Query: 530 FSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQ 589
+ R++ KSDVWSFG+L+ E+ ++G++PY +N EV+E + G+R+ P+ +++
Sbjct: 435 ALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHE 494
Query: 590 IMNHCWKERPEDRPAFSRL 608
+M HCWK+ PE+RP F L
Sbjct: 495 LMIHCWKKDPEERPTFEYL 513
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 309 bits (792), Expect = 4e-84
Identities = 167/445 (37%), Positives = 264/445 (59%), Gaps = 21/445 (4%)
Query: 170 EPEETVVIALYDYQTNDPQELALRRNEEYCLLDSSEI-HWWRVQDRNGHEGYVPSSYLVE 228
E + + +ALYD+ + L++ + E+ +L + W Q +NG +G+VPS+Y+
Sbjct: 60 ENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNG-QGWVPSNYITP 118
Query: 229 KSPNNLETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRTA-GTYTVSVFTKAVVSENN 287
N+LE + WY+ +SR+ AE LL +G G+F+VR+S ++ G ++S+ + V
Sbjct: 119 V--NSLEKHSWYHGPVSRNAAE-YLLSSGINGSFLVRESESSPGQRSISLRYEGRVY--- 172
Query: 288 PCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPV 347
HY I +D + YV+ + F+++ L+++H GL+T L YP ++ P
Sbjct: 173 ----HYRINTASDG--KLYVSSESRFNTLAELVHHHSTVADGLITTLHYPA--PKRNKPT 224
Query: 348 TAGL--RYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKD-KVAIKTIREGAMSEEDFI 404
G+ Y KW ++ +++T ++G GQ+G V+ G W VA+KT++E M E+F+
Sbjct: 225 VYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFL 284
Query: 405 EEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRT-QRGLFAAETLLGMC 463
+EA VM ++ HP LVQL GVC + P ++ EFM +G L DYLR R A LL M
Sbjct: 285 KEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMA 344
Query: 464 LDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVK 523
+ M YLE+ IHRDLAARNCLVGEN ++KV+DFG++R + D YT+ G KFP+K
Sbjct: 345 TQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIK 404
Query: 524 WASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLA 583
W +PE +++++S KSDVW+FGVL+WE+ + G PY S+V E + +R+ +P
Sbjct: 405 WTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGC 464
Query: 584 STHVYQIMNHCWKERPEDRPAFSRL 608
VY++M CW+ P DRP+F+ +
Sbjct: 465 PEKVYELMRACWQWNPSDRPSFAEI 489
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 309 bits (792), Expect = 4e-84
Identities = 167/445 (37%), Positives = 264/445 (59%), Gaps = 21/445 (4%)
Query: 170 EPEETVVIALYDYQTNDPQELALRRNEEYCLLDSSEI-HWWRVQDRNGHEGYVPSSYLVE 228
E + + +ALYD+ + L++ + E+ +L + W Q +NG +G+VPS+Y+
Sbjct: 79 ENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNG-QGWVPSNYITP 137
Query: 229 KSPNNLETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRTA-GTYTVSVFTKAVVSENN 287
N+LE + WY+ +SR+ AE LL +G G+F+VR+S ++ G ++S+ + V
Sbjct: 138 V--NSLEKHSWYHGPVSRNAAE-YLLSSGINGSFLVRESESSPGQRSISLRYEGRVY--- 191
Query: 288 PCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPV 347
HY I +D + YV+ + F+++ L+++H GL+T L YP ++ P
Sbjct: 192 ----HYRINTASDG--KLYVSSESRFNTLAELVHHHSTVADGLITTLHYPA--PKRNKPT 243
Query: 348 TAGL--RYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKD-KVAIKTIREGAMSEEDFI 404
G+ Y KW ++ +++T ++G GQ+G V+ G W VA+KT++E M E+F+
Sbjct: 244 VYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFL 303
Query: 405 EEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRT-QRGLFAAETLLGMC 463
+EA VM ++ HP LVQL GVC + P ++ EFM +G L DYLR R A LL M
Sbjct: 304 KEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMA 363
Query: 464 LDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVK 523
+ M YLE+ IHRDLAARNCLVGEN ++KV+DFG++R + D YT+ G KFP+K
Sbjct: 364 TQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIK 423
Query: 524 WASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLA 583
W +PE +++++S KSDVW+FGVL+WE+ + G PY S+V E + +R+ +P
Sbjct: 424 WTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGC 483
Query: 584 STHVYQIMNHCWKERPEDRPAFSRL 608
VY++M CW+ P DRP+F+ +
Sbjct: 484 PEKVYELMRACWQWNPSDRPSFAEI 508
>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform B [Homo sapiens]
Length = 491
Score = 309 bits (792), Expect = 4e-84
Identities = 174/464 (37%), Positives = 267/464 (57%), Gaps = 28/464 (6%)
Query: 159 PTPEDNRRP-----LWEPEET--VVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRV 211
P PE P +PEE +V+ALY Y P +L+ ++ E+ +L+ WW+
Sbjct: 23 PVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHG-EWWKA 81
Query: 212 QDR-NGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKE-GAFMVRDSRT 269
+ EG++PS+Y+ + N LET EW+ K I+R AE+ LL G GAF++R+S T
Sbjct: 82 KSLLTKKEGFIPSNYVAKL--NTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESET 139
Query: 270 A-GTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGG 328
G++++SV V + IKHY I+ ++ YY++ + F I +I ++Q
Sbjct: 140 LKGSFSLSVRDFDPV--HGDVIKHYKIRSLDNGG--YYISPRITFPCISDMIKHYQKQAD 195
Query: 329 GLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKV 388
GL RL + + P W I + V+ +G+GQFG V +GY+ N KV
Sbjct: 196 GLCRRLEKACISPKPQKPWDKDA----WEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKV 251
Query: 389 AIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLR 448
A+KT++ G MS + F+EEA +M L H KLV+LY V + PI ++ E+M G L D+L+
Sbjct: 252 AVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLK 311
Query: 449 TQRGLFAAETLLGMCLD----VCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMT 504
+ G + LL +D + EGMAY+E IHRDL A N LV E+ + K++DFG+
Sbjct: 312 SDEG---GKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLA 368
Query: 505 RFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSN 564
R + D++YT+ G KFP+KW +PE +F ++ KSDVWSFG+L++E+ + GKIPY R+N
Sbjct: 369 RVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTN 428
Query: 565 SEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRL 608
++V+ +S G+R+ + +Y IM CWKE+ E+RP F L
Sbjct: 429 ADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYL 472
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 309 bits (791), Expect = 6e-84
Identities = 172/469 (36%), Positives = 270/469 (57%), Gaps = 18/469 (3%)
Query: 143 CAQYDPTKNASKKPLPPTPEDNRRPLWEP--EETVVIALYDYQTNDPQELALRRNEEYCL 200
C Y P ++ KP P + N + E E+ +V+ALYDY+ ++L+ ++ ++ +
Sbjct: 48 CPVYVPDPTSTIKPGPNSHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVV 107
Query: 201 LDSSEIHWWRVQD-RNGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKE 259
L+ S WW+ + EGY+PS+Y+ ++LET EW+ K ISR AE+ LL G
Sbjct: 108 LEESG-EWWKARSLATRKEGYIPSNYVARV--DSLETEEWFFKGISRKDAERQLLAPGNM 164
Query: 260 -GAFMVRDSRTA-GTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIP 317
G+FM+RDS T G+Y++SV + +KHY I+ T DN +Y++ + F ++
Sbjct: 165 LGSFMIRDSETTKGSYSLSV--RDYDPRQGDTVKHYKIR-TLDNGG-FYISPRSTFSTLQ 220
Query: 318 LLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDPSELTFVQEIGSGQFGLV 377
L+++++ GL +L P + + P W I L +++G+GQFG V
Sbjct: 221 ELVDHYKKGNDGLCQKLSVPCMSSKPQKP----WEKDAWEIPRESLKLEKKLGAGQFGEV 276
Query: 378 HLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEF 437
+ + KVA+KT++ G+MS E F+ EA VM L H KLV+L+ V ++ PI ++ EF
Sbjct: 277 WMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKE-PIYIITEF 335
Query: 438 MEHGCLSDYLRTQRGLFAA-ETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVI 496
M G L D+L++ G L+ + EGMA++E+ IHRDL A N LV + V
Sbjct: 336 MAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVC 395
Query: 497 KVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGK 556
K++DFG+ R + D++YT+ G KFP+KW +PE +F ++ KSDVWSFG+L+ E+ + G+
Sbjct: 396 KIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGR 455
Query: 557 IPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAF 605
IPY SN EV+ + G+R+ +P +Y IM CWK RPE+RP F
Sbjct: 456 IPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTF 504
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 305 bits (782), Expect = 6e-83
Identities = 166/439 (37%), Positives = 255/439 (58%), Gaps = 14/439 (3%)
Query: 174 TVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRN-GHEGYVPSSYLVEKSPN 232
T +ALYDY++ +L+ ++ E +++++E WW + G GY+PS+Y+ +
Sbjct: 87 TTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPS--D 144
Query: 233 NLETYEWYNKSISRDKAEKLLLDT-GKEGAFMVRDSRTA-GTYTVSVFTKAVVSENNPCI 290
+++ EWY I+R ++E+LLL+ G F+VR+S T G Y +SV N +
Sbjct: 145 SIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLN--V 202
Query: 291 KHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAG 350
KHY I++ + +Y+ + F+S+ L+ Y+ + GL RL VC P T G
Sbjct: 203 KHYKIRKLDSGG--FYITSRTQFNSLQQLVAYYSKHADGLCHRLT-TVC--PTSKPQTQG 257
Query: 351 LRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVM 410
L W I L ++G G FG V +G W +VAIKT++ G MS E F++EA+VM
Sbjct: 258 LAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVM 317
Query: 411 MKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAA-ETLLGMCLDVCEG 469
KL H KLVQLY V E+ PI +V E+M G L D+L+ + G + L+ M + G
Sbjct: 318 KKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376
Query: 470 MAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEV 529
MAY+E +HRDL A N LVGEN V KV+DFG+ R + D++YT+ G KFP+KW +PE
Sbjct: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA 436
Query: 530 FSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQ 589
+ R++ KSDVWSFG+L+ E+ ++G++PY N EV++ + G+R+ P ++
Sbjct: 437 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHD 496
Query: 590 IMNHCWKERPEDRPAFSRL 608
+M CW++ PE+RP F L
Sbjct: 497 LMCQCWRKEPEERPTFEYL 515
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 305 bits (782), Expect = 6e-83
Identities = 166/439 (37%), Positives = 255/439 (58%), Gaps = 14/439 (3%)
Query: 174 TVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRN-GHEGYVPSSYLVEKSPN 232
T +ALYDY++ +L+ ++ E +++++E WW + G GY+PS+Y+ +
Sbjct: 87 TTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPS--D 144
Query: 233 NLETYEWYNKSISRDKAEKLLLDT-GKEGAFMVRDSRTA-GTYTVSVFTKAVVSENNPCI 290
+++ EWY I+R ++E+LLL+ G F+VR+S T G Y +SV N +
Sbjct: 145 SIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLN--V 202
Query: 291 KHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAG 350
KHY I++ + +Y+ + F+S+ L+ Y+ + GL RL VC P T G
Sbjct: 203 KHYKIRKLDSGG--FYITSRTQFNSLQQLVAYYSKHADGLCHRLT-TVC--PTSKPQTQG 257
Query: 351 LRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVM 410
L W I L ++G G FG V +G W +VAIKT++ G MS E F++EA+VM
Sbjct: 258 LAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVM 317
Query: 411 MKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAA-ETLLGMCLDVCEG 469
KL H KLVQLY V E+ PI +V E+M G L D+L+ + G + L+ M + G
Sbjct: 318 KKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376
Query: 470 MAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEV 529
MAY+E +HRDL A N LVGEN V KV+DFG+ R + D++YT+ G KFP+KW +PE
Sbjct: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA 436
Query: 530 FSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQ 589
+ R++ KSDVWSFG+L+ E+ ++G++PY N EV++ + G+R+ P ++
Sbjct: 437 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHD 496
Query: 590 IMNHCWKERPEDRPAFSRL 608
+M CW++ PE+RP F L
Sbjct: 497 LMCQCWRKEPEERPTFEYL 515
>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
Length = 505
Score = 305 bits (782), Expect = 6e-83
Identities = 179/479 (37%), Positives = 271/479 (56%), Gaps = 29/479 (6%)
Query: 145 QYDPTKNASKK----PLPPTPEDNRRPLWEPEETV------VIALYDYQTNDPQELALRR 194
Q+ P K +++ PLPP N P+E + V+ALYDY + ++L + +
Sbjct: 22 QWSPLKVSAQDKDAPPLPPLVVFNHLTPPPPDEHLDEDKHFVVALYDYTAMNDRDLQMLK 81
Query: 195 NEEYCLLDSSEIHWWRVQDR-NGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEK-L 252
E+ +L + WW + G EGYVPS+++ +LE W+ +S R +AE+ L
Sbjct: 82 GEKLQVLKGTG-DWWLARSLVTGREGYVPSNFVARVE--SLEMERWFFRSQGRKEAERQL 138
Query: 253 LLDTGKEGAFMVRDSRT-AGTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKY 311
L K G+F++R+S T G +++SV V+ IKHY I+ ++ YY++ +
Sbjct: 139 LAPINKAGSFLIRESETNKGAFSLSVKD---VTTQGELIKHYKIRCLDEGG--YYISPRI 193
Query: 312 VFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDPSELTFVQEIGS 371
F S+ L+ ++ G GL RL P + P +W I L V+++GS
Sbjct: 194 TFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWAQD----EWEIPRQSLRLVRKLGS 249
Query: 372 GQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPI 431
GQFG V +GY+ N KVAIKT++EG MS E F+ EA VM L H +LV+LY V ++ PI
Sbjct: 250 GQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLYAVVTKE-PI 308
Query: 432 CLVFEFMEHGCLSDYLRTQRGL-FAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLV 490
+V E+M GCL D+L+T G + L+ M + EGMAY+E IHRDL A N LV
Sbjct: 309 YIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILV 368
Query: 491 GENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWE 550
E K++DFG+ R ++D +YT+ G KFP+KW +PE F ++ K+DVWSFGVL+ E
Sbjct: 369 SEALCCKIADFGLAR-IIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLME 427
Query: 551 VFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQ-IMNHCWKERPEDRPAFSRL 608
V + G++PY SN EV+ ++ G+R+ +P +Y+ ++ CW+ RPE+RP F L
Sbjct: 428 VVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEERPTFEFL 486
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 305 bits (780), Expect = 1e-82
Identities = 174/471 (36%), Positives = 271/471 (57%), Gaps = 24/471 (5%)
Query: 142 GCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALYDYQTNDPQELALRRNEEYCLL 201
GC D A + + + ++N E + + +ALYD+ + L++ + E+ +L
Sbjct: 66 GC---DVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVL 122
Query: 202 DSSEI-HWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKEG 260
++ W V+ +NG +G+VPS+Y+ N+LE + WY+ +SR AE LL + G
Sbjct: 123 GYNQNGEWSEVRSKNG-QGWVPSNYITPV--NSLEKHSWYHGPVSRSAAE-YLLSSLING 178
Query: 261 AFMVRDSRTA-GTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLL 319
+F+VR+S ++ G ++S+ + V HY I T D + YV + F ++ L
Sbjct: 179 SFLVRESESSPGQLSISLRYEGRVY-------HYRINTTADG--KVYVTAESRFSTLAEL 229
Query: 320 INYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLR--YGKWVIDPSELTFVQEIGSGQFGLV 377
+++H GLVT L YP + P G+ + KW ++ +++T ++G GQ+G V
Sbjct: 230 VHHHSTVADGLVTTLHYPA--PKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEV 287
Query: 378 HLGYWLNKD-KVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFE 436
++G W VA+KT++E M E+F++EA VM ++ HP LVQL GVC + P +V E
Sbjct: 288 YVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTE 347
Query: 437 FMEHGCLSDYLRT-QRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQV 495
+M +G L DYLR R A LL M + M YLE+ IHRDLAARNCLVGEN V
Sbjct: 348 YMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHV 407
Query: 496 IKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEG 555
+KV+DFG++R + D YT+ G KFP+KW +PE +++ +S KSDVW+FGVL+WE+ + G
Sbjct: 408 VKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYG 467
Query: 556 KIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFS 606
PY S+V + + G+R+ +P VY++M CWK P DRP+F+
Sbjct: 468 MSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFA 518
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 305 bits (780), Expect = 1e-82
Identities = 174/471 (36%), Positives = 271/471 (57%), Gaps = 24/471 (5%)
Query: 142 GCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALYDYQTNDPQELALRRNEEYCLL 201
GC D A + + + ++N E + + +ALYD+ + L++ + E+ +L
Sbjct: 81 GC---DVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVL 137
Query: 202 DSSEI-HWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKEG 260
++ W V+ +NG +G+VPS+Y+ N+LE + WY+ +SR AE LL + G
Sbjct: 138 GYNQNGEWSEVRSKNG-QGWVPSNYITPV--NSLEKHSWYHGPVSRSAAE-YLLSSLING 193
Query: 261 AFMVRDSRTA-GTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLL 319
+F+VR+S ++ G ++S+ + V HY I T D + YV + F ++ L
Sbjct: 194 SFLVRESESSPGQLSISLRYEGRVY-------HYRINTTADG--KVYVTAESRFSTLAEL 244
Query: 320 INYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLR--YGKWVIDPSELTFVQEIGSGQFGLV 377
+++H GLVT L YP + P G+ + KW ++ +++T ++G GQ+G V
Sbjct: 245 VHHHSTVADGLVTTLHYPA--PKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEV 302
Query: 378 HLGYWLNKD-KVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFE 436
++G W VA+KT++E M E+F++EA VM ++ HP LVQL GVC + P +V E
Sbjct: 303 YVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTE 362
Query: 437 FMEHGCLSDYLRT-QRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQV 495
+M +G L DYLR R A LL M + M YLE+ IHRDLAARNCLVGEN V
Sbjct: 363 YMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHV 422
Query: 496 IKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEG 555
+KV+DFG++R + D YT+ G KFP+KW +PE +++ +S KSDVW+FGVL+WE+ + G
Sbjct: 423 VKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYG 482
Query: 556 KIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFS 606
PY S+V + + G+R+ +P VY++M CWK P DRP+F+
Sbjct: 483 MSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFA 533
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 305 bits (780), Expect = 1e-82
Identities = 174/471 (36%), Positives = 271/471 (57%), Gaps = 24/471 (5%)
Query: 142 GCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALYDYQTNDPQELALRRNEEYCLL 201
GC D A + + + ++N E + + +ALYD+ + L++ + E+ +L
Sbjct: 60 GC---DVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVL 116
Query: 202 DSSEI-HWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKEG 260
++ W V+ +NG +G+VPS+Y+ N+LE + WY+ +SR AE LL + G
Sbjct: 117 GYNQNGEWSEVRSKNG-QGWVPSNYITPV--NSLEKHSWYHGPVSRSAAE-YLLSSLING 172
Query: 261 AFMVRDSRTA-GTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLL 319
+F+VR+S ++ G ++S+ + V HY I T D + YV + F ++ L
Sbjct: 173 SFLVRESESSPGQLSISLRYEGRVY-------HYRINTTADG--KVYVTAESRFSTLAEL 223
Query: 320 INYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLR--YGKWVIDPSELTFVQEIGSGQFGLV 377
+++H GLVT L YP + P G+ + KW ++ +++T ++G GQ+G V
Sbjct: 224 VHHHSTVADGLVTTLHYPA--PKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEV 281
Query: 378 HLGYWLNKD-KVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFE 436
++G W VA+KT++E M E+F++EA VM ++ HP LVQL GVC + P +V E
Sbjct: 282 YVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTE 341
Query: 437 FMEHGCLSDYLRT-QRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQV 495
+M +G L DYLR R A LL M + M YLE+ IHRDLAARNCLVGEN V
Sbjct: 342 YMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHV 401
Query: 496 IKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEG 555
+KV+DFG++R + D YT+ G KFP+KW +PE +++ +S KSDVW+FGVL+WE+ + G
Sbjct: 402 VKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYG 461
Query: 556 KIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFS 606
PY S+V + + G+R+ +P VY++M CWK P DRP+F+
Sbjct: 462 MSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFA 512
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 305 bits (780), Expect = 1e-82
Identities = 174/471 (36%), Positives = 271/471 (57%), Gaps = 24/471 (5%)
Query: 142 GCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALYDYQTNDPQELALRRNEEYCLL 201
GC D A + + + ++N E + + +ALYD+ + L++ + E+ +L
Sbjct: 66 GC---DVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVL 122
Query: 202 DSSEI-HWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKEG 260
++ W V+ +NG +G+VPS+Y+ N+LE + WY+ +SR AE LL + G
Sbjct: 123 GYNQNGEWSEVRSKNG-QGWVPSNYITPV--NSLEKHSWYHGPVSRSAAE-YLLSSLING 178
Query: 261 AFMVRDSRTA-GTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLL 319
+F+VR+S ++ G ++S+ + V HY I T D + YV + F ++ L
Sbjct: 179 SFLVRESESSPGQLSISLRYEGRVY-------HYRINTTADG--KVYVTAESRFSTLAEL 229
Query: 320 INYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLR--YGKWVIDPSELTFVQEIGSGQFGLV 377
+++H GLVT L YP + P G+ + KW ++ +++T ++G GQ+G V
Sbjct: 230 VHHHSTVADGLVTTLHYPA--PKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEV 287
Query: 378 HLGYWLNKD-KVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFE 436
++G W VA+KT++E M E+F++EA VM ++ HP LVQL GVC + P +V E
Sbjct: 288 YVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTE 347
Query: 437 FMEHGCLSDYLRT-QRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQV 495
+M +G L DYLR R A LL M + M YLE+ IHRDLAARNCLVGEN V
Sbjct: 348 YMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHV 407
Query: 496 IKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEG 555
+KV+DFG++R + D YT+ G KFP+KW +PE +++ +S KSDVW+FGVL+WE+ + G
Sbjct: 408 VKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYG 467
Query: 556 KIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFS 606
PY S+V + + G+R+ +P VY++M CWK P DRP+F+
Sbjct: 468 MSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFA 518
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 305 bits (780), Expect = 1e-82
Identities = 174/471 (36%), Positives = 271/471 (57%), Gaps = 24/471 (5%)
Query: 142 GCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALYDYQTNDPQELALRRNEEYCLL 201
GC D A + + + ++N E + + +ALYD+ + L++ + E+ +L
Sbjct: 45 GC---DVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVL 101
Query: 202 DSSEI-HWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKEG 260
++ W V+ +NG +G+VPS+Y+ N+LE + WY+ +SR AE LL + G
Sbjct: 102 GYNQNGEWSEVRSKNG-QGWVPSNYITPV--NSLEKHSWYHGPVSRSAAE-YLLSSLING 157
Query: 261 AFMVRDSRTA-GTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLL 319
+F+VR+S ++ G ++S+ + V HY I T D + YV + F ++ L
Sbjct: 158 SFLVRESESSPGQLSISLRYEGRVY-------HYRINTTADG--KVYVTAESRFSTLAEL 208
Query: 320 INYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLR--YGKWVIDPSELTFVQEIGSGQFGLV 377
+++H GLVT L YP + P G+ + KW ++ +++T ++G GQ+G V
Sbjct: 209 VHHHSTVADGLVTTLHYPA--PKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEV 266
Query: 378 HLGYWLNKD-KVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFE 436
++G W VA+KT++E M E+F++EA VM ++ HP LVQL GVC + P +V E
Sbjct: 267 YVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTE 326
Query: 437 FMEHGCLSDYLRT-QRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQV 495
+M +G L DYLR R A LL M + M YLE+ IHRDLAARNCLVGEN V
Sbjct: 327 YMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHV 386
Query: 496 IKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEG 555
+KV+DFG++R + D YT+ G KFP+KW +PE +++ +S KSDVW+FGVL+WE+ + G
Sbjct: 387 VKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYG 446
Query: 556 KIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFS 606
PY S+V + + G+R+ +P VY++M CWK P DRP+F+
Sbjct: 447 MSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFA 497
>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 305 bits (780), Expect = 1e-82
Identities = 168/439 (38%), Positives = 249/439 (56%), Gaps = 14/439 (3%)
Query: 174 TVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQD-RNGHEGYVPSSYLVEKSPN 232
T+ IALYDY+ +L + E++ +L+++E WW + +G G +PS+Y+ +
Sbjct: 80 TLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPV--D 137
Query: 233 NLETYEWYNKSISRDKAEKLLLDTGK-EGAFMVRDSRTA-GTYTVSVFTKAVVSENNPCI 290
+++ EWY I R AE+ LL G +GAF++R+S T G Y++S+ + +
Sbjct: 138 SIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSI--RDWDQTRGDHV 195
Query: 291 KHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAG 350
KHY I++ + YY+ + F+S+ L+ ++ GL L P + P T G
Sbjct: 196 KHYKIRKLDMGG--YYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMK---PQTLG 250
Query: 351 LRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVM 410
L W I S +T + +G+G FG V LG W KVA+KT++ G MS + F+EEA+VM
Sbjct: 251 LAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVM 310
Query: 411 MKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGL-FAAETLLGMCLDVCEG 469
L H KLVQLY V E+ PI +V EFM HG L D+L+ G L+ M V EG
Sbjct: 311 KLLRHDKLVQLYAVVSEE-PIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEG 369
Query: 470 MAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEV 529
MAY+E IHRDL A N LVGE K++DFG+ R + DD+Y G+KFP+KW +PE
Sbjct: 370 MAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEA 429
Query: 530 FSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQ 589
F R++ KSDVWSFG+L+ E+ ++G+IPY + EV+E + G+ + P +Y+
Sbjct: 430 ALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYE 489
Query: 590 IMNHCWKERPEDRPAFSRL 608
M W+ PE+RP F L
Sbjct: 490 AMEQTWRLDPEERPTFEYL 508
>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 305 bits (780), Expect = 1e-82
Identities = 168/439 (38%), Positives = 249/439 (56%), Gaps = 14/439 (3%)
Query: 174 TVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQD-RNGHEGYVPSSYLVEKSPN 232
T+ IALYDY+ +L + E++ +L+++E WW + +G G +PS+Y+ +
Sbjct: 80 TLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPV--D 137
Query: 233 NLETYEWYNKSISRDKAEKLLLDTGK-EGAFMVRDSRTA-GTYTVSVFTKAVVSENNPCI 290
+++ EWY I R AE+ LL G +GAF++R+S T G Y++S+ + +
Sbjct: 138 SIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSI--RDWDQTRGDHV 195
Query: 291 KHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAG 350
KHY I++ + YY+ + F+S+ L+ ++ GL L P + P T G
Sbjct: 196 KHYKIRKLDMGG--YYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMK---PQTLG 250
Query: 351 LRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVM 410
L W I S +T + +G+G FG V LG W KVA+KT++ G MS + F+EEA+VM
Sbjct: 251 LAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVM 310
Query: 411 MKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGL-FAAETLLGMCLDVCEG 469
L H KLVQLY V E+ PI +V EFM HG L D+L+ G L+ M V EG
Sbjct: 311 KLLRHDKLVQLYAVVSEE-PIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEG 369
Query: 470 MAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEV 529
MAY+E IHRDL A N LVGE K++DFG+ R + DD+Y G+KFP+KW +PE
Sbjct: 370 MAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEA 429
Query: 530 FSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQ 589
F R++ KSDVWSFG+L+ E+ ++G+IPY + EV+E + G+ + P +Y+
Sbjct: 430 ALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYE 489
Query: 590 IMNHCWKERPEDRPAFSRL 608
M W+ PE+RP F L
Sbjct: 490 AMEQTWRLDPEERPTFEYL 508
>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 305 bits (780), Expect = 1e-82
Identities = 168/439 (38%), Positives = 249/439 (56%), Gaps = 14/439 (3%)
Query: 174 TVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQD-RNGHEGYVPSSYLVEKSPN 232
T+ IALYDY+ +L + E++ +L+++E WW + +G G +PS+Y+ +
Sbjct: 80 TLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPV--D 137
Query: 233 NLETYEWYNKSISRDKAEKLLLDTGK-EGAFMVRDSRTA-GTYTVSVFTKAVVSENNPCI 290
+++ EWY I R AE+ LL G +GAF++R+S T G Y++S+ + +
Sbjct: 138 SIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSI--RDWDQTRGDHV 195
Query: 291 KHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAG 350
KHY I++ + YY+ + F+S+ L+ ++ GL L P + P T G
Sbjct: 196 KHYKIRKLDMGG--YYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMK---PQTLG 250
Query: 351 LRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVM 410
L W I S +T + +G+G FG V LG W KVA+KT++ G MS + F+EEA+VM
Sbjct: 251 LAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVM 310
Query: 411 MKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGL-FAAETLLGMCLDVCEG 469
L H KLVQLY V E+ PI +V EFM HG L D+L+ G L+ M V EG
Sbjct: 311 KLLRHDKLVQLYAVVSEE-PIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEG 369
Query: 470 MAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEV 529
MAY+E IHRDL A N LVGE K++DFG+ R + DD+Y G+KFP+KW +PE
Sbjct: 370 MAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEA 429
Query: 530 FSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQ 589
F R++ KSDVWSFG+L+ E+ ++G+IPY + EV+E + G+ + P +Y+
Sbjct: 430 ALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYE 489
Query: 590 IMNHCWKERPEDRPAFSRL 608
M W+ PE+RP F L
Sbjct: 490 AMEQTWRLDPEERPTFEYL 508
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 296 bits (759), Expect = 3e-80
Identities = 166/457 (36%), Positives = 258/457 (56%), Gaps = 26/457 (5%)
Query: 177 IALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQD----RNGH----EGYVPSSYLVE 228
+AL+DYQ ++L+ R ++ +LD+ WW + R+G +GY+PS+Y+ E
Sbjct: 48 VALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAE 107
Query: 229 KSPNNLETYEWYNKSISRDKAEK-LLLDTGKEGAFMVRDSRTA-GTYTVSVFTKAVVSEN 286
+L+ W+ +I R AEK LL K G+F++R+S + G +++SV AVV
Sbjct: 108 D--RSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVV--- 162
Query: 287 NPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAP 346
KHY IK ++ +++ + +F ++ ++++ GL +L P + AP
Sbjct: 163 ----KHYRIKRLDEGG--FFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAP 216
Query: 347 VTAGLR-YGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIE 405
+ +W ID + + ++ +GSGQFG V G W N VA+KT++ G+M DF+
Sbjct: 217 FDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLR 276
Query: 406 EAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAET-LLGMCL 464
EA++M L HPKL+QLY VC + PI ++ E M HG L +YL+ G T + M
Sbjct: 277 EAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAA 336
Query: 465 DVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTR-FVLD--DQYTSSTGTKFP 521
V GMAYLE IHRDLAARN LVGE+ + KV+DFG+ R F +D D Y S K P
Sbjct: 337 QVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLP 396
Query: 522 VKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPR 581
VKW +PE +++S KSDVWSFG+L++E+ + GK+PY + ++V++ ++ +RL +P
Sbjct: 397 VKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPS 456
Query: 582 LASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIAES 618
Y IM CW P++RP F L +L + E+
Sbjct: 457 NCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYFET 493
>gi|18250298 src-related kinase lacking C-terminal regulatory
tyrosine and N-terminal myristylation sites [Homo
sapiens]
Length = 488
Score = 273 bits (698), Expect = 3e-73
Identities = 168/473 (35%), Positives = 244/473 (51%), Gaps = 32/473 (6%)
Query: 147 DPTKNASKKPLPPTPEDNRRPLWEPEETVVIALYDYQTNDPQELALRRNEEYCLLDSSEI 206
DP +P P P+ + +ALYD+ EL++RR + C L+
Sbjct: 39 DPVPTLPAEPCSPFPQ------------LFLALYDFTARCGGELSVRRGDRLCALEEGGG 86
Query: 207 HWW-RVQDRNGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKE-GAFMV 264
+ + R G VP +++ + SP L WY +SR +A++LLL E GAF++
Sbjct: 87 YIFARRLSGQPSAGLVPITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLI 146
Query: 265 RDSRTA-GTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINYH 323
R S ++ G Y++SV +A V HY + D Y+ + +F + L+ Y+
Sbjct: 147 RPSESSLGGYSLSVRAQAKVC-------HYRVSMAADGS--LYLQKGRLFPGLEELLTYY 197
Query: 324 QHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWL 383
+ N + L P QKAP R W SE +++G G FG V G WL
Sbjct: 198 KANWKLIQNPLLQPCM--PQKAP-----RQDVWERPHSEFALGRKLGEGYFGEVWEGLWL 250
Query: 384 NKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCL 443
VAIK I+ M D +E + + L H +L++L+ VC P+ +V E M G L
Sbjct: 251 GSLPVAIKVIKSANMKLTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNL 310
Query: 444 SDYLRTQRG-LFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFG 502
+L T G LLG V EGM+YLEE V+HRDLAARN LV + KV+DFG
Sbjct: 311 QAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFG 370
Query: 503 MTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENR 562
+ R + DD Y+ S+ +K PVKW +PE ++ +S KSDVWSFGVL+ EVF+ G+ PYE
Sbjct: 371 LARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGM 430
Query: 563 SNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEI 615
+N E ++ I G+RL +P VY +M CW+ PE+RP+F+ L +L I
Sbjct: 431 TNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSSPEERPSFATLREKLHAI 483
>gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]
Length = 482
Score = 270 bits (690), Expect = 3e-72
Identities = 150/439 (34%), Positives = 236/439 (53%), Gaps = 66/439 (15%)
Query: 174 TVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQD-RNGHEGYVPSSYLVEKSPN 232
T+ +ALYDY+ +L+ + E++ +L+SSE WW + G GY+PS+Y+ +
Sbjct: 85 TLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPV--D 142
Query: 233 NLETYEWYNKSISRDKAEKLLLDTGK-EGAFMVRDSRTA-GTYTVSVFTKAVVSENNPCI 290
+++ EWY + R AE+ LL G G F++R+S T G Y++S+ + ++ +
Sbjct: 143 SIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDH--V 200
Query: 291 KHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAG 350
KHY I++ ++ YY+ + F+++ L+ QH
Sbjct: 201 KHYKIRKLDNGG--YYITTRAQFETLQQLV---QH------------------------- 230
Query: 351 LRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVM 410
+ G W KVAIKT++ G MS E F+EEA++M
Sbjct: 231 ---------------------------YSGTWNGNTKVAIKTLKPGTMSPESFLEEAQIM 263
Query: 411 MKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRG-LFAAETLLGMCLDVCEG 469
KL H KLVQLY V E+ PI +V E+M G L D+L+ G L+ M V G
Sbjct: 264 KKLKHDKLVQLYAVVSEE-PIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAG 322
Query: 470 MAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEV 529
MAY+E IHRDL + N LVG + K++DFG+ R + D++YT+ G KFP+KW +PE
Sbjct: 323 MAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEA 382
Query: 530 FSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQ 589
+ R++ KSDVWSFG+L+ E+ ++G++PY +N EV+E + G+R+ P+ +++
Sbjct: 383 ALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHE 442
Query: 590 IMNHCWKERPEDRPAFSRL 608
+M HCWK+ PE+RP F L
Sbjct: 443 LMIHCWKKDPEERPTFEYL 461
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,219,835
Number of Sequences: 37866
Number of extensions: 1111118
Number of successful extensions: 5178
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 638
Number of HSP's successfully gapped in prelim test: 362
Number of HSP's that attempted gapping in prelim test: 2926
Number of HSP's gapped (non-prelim): 1258
length of query: 620
length of database: 18,247,518
effective HSP length: 108
effective length of query: 512
effective length of database: 14,157,990
effective search space: 7248890880
effective search space used: 7248890880
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.