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Search of human proteins with 153266757
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
(1146 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 2314 0.0
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 2302 0.0
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 2239 0.0
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 1314 0.0
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 1082 0.0
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 1080 0.0
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 983 0.0
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] 371 e-102
gi|4503787 fyn-related kinase [Homo sapiens] 370 e-102
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 369 e-101
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens] 368 e-101
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 364 e-100
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 364 e-100
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi... 364 e-100
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 359 7e-99
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 359 7e-99
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 358 1e-98
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 358 1e-98
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 355 2e-97
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ... 348 2e-95
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is... 347 4e-95
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens] 344 2e-94
gi|130977759 tec protein tyrosine kinase [Homo sapiens] 332 1e-90
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens] 331 3e-90
gi|148596974 TXK tyrosine kinase [Homo sapiens] 322 1e-87
gi|187475373 c-src tyrosine kinase [Homo sapiens] 316 7e-86
gi|4758078 c-src tyrosine kinase [Homo sapiens] 316 7e-86
gi|18250298 src-related kinase lacking C-terminal regulatory tyr... 305 2e-82
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens] 305 2e-82
gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens] 295 2e-79
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 2314 bits (5997), Expect = 0.0
Identities = 1146/1146 (100%), Positives = 1146/1146 (100%)
Query: 1 MVLGTVLLPPNSYGRDQDTSLCCLCTEASESALPDLTEALHRPYGCDVEPQALNEAIRWS 60
MVLGTVLLPPNSYGRDQDTSLCCLCTEASESALPDLTEALHRPYGCDVEPQALNEAIRWS
Sbjct: 1 MVLGTVLLPPNSYGRDQDTSLCCLCTEASESALPDLTEALHRPYGCDVEPQALNEAIRWS 60
Query: 61 SKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGW 120
SKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGW
Sbjct: 61 SKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGW 120
Query: 121 VPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGR 180
VPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGR
Sbjct: 121 VPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGR 180
Query: 181 VYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSP 240
VYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSP
Sbjct: 181 VYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSP 240
Query: 241 IHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVM 300
IHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVM
Sbjct: 241 IHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVM 300
Query: 301 KEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSA 360
KEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSA
Sbjct: 301 KEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSA 360
Query: 361 MEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPES 420
MEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPES
Sbjct: 361 MEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPES 420
Query: 421 LAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYE 480
LAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYE
Sbjct: 421 LAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYE 480
Query: 481 LMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILP 540
LMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILP
Sbjct: 481 LMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILP 540
Query: 541 SKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLL 600
SKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLL
Sbjct: 541 SKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLL 600
Query: 601 EDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQ 660
EDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQ
Sbjct: 601 EDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQ 660
Query: 661 HADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRL 720
HADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRL
Sbjct: 661 HADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRL 720
Query: 721 IKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTV 780
IKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTV
Sbjct: 721 IKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTV 780
Query: 781 STSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDP 840
STSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDP
Sbjct: 781 STSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDP 840
Query: 841 PGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLIS 900
PGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLIS
Sbjct: 841 PGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLIS 900
Query: 901 PTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHP 960
PTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHP
Sbjct: 901 PTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHP 960
Query: 961 SICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPA 1020
SICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPA
Sbjct: 961 SICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPA 1020
Query: 1021 KMANGTAGTKVALRKTKQAAEKISADKISKEALLECADLLSSALTEPVPNSQLVDTGHQL 1080
KMANGTAGTKVALRKTKQAAEKISADKISKEALLECADLLSSALTEPVPNSQLVDTGHQL
Sbjct: 1021 KMANGTAGTKVALRKTKQAAEKISADKISKEALLECADLLSSALTEPVPNSQLVDTGHQL 1080
Query: 1081 LDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEI 1140
LDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEI
Sbjct: 1081 LDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEI 1140
Query: 1141 SDVVQR 1146
SDVVQR
Sbjct: 1141 SDVVQR 1146
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 2302 bits (5965), Expect = 0.0
Identities = 1146/1167 (98%), Positives = 1146/1167 (98%), Gaps = 21/1167 (1%)
Query: 1 MVLGTVLLPPNSYGRDQDTSLCCLCTEASESALPDLT---------------------EA 39
MVLGTVLLPPNSYGRDQDTSLCCLCTEASESALPDLT EA
Sbjct: 1 MVLGTVLLPPNSYGRDQDTSLCCLCTEASESALPDLTDHFASCVEDGFEGDKTGGSSPEA 60
Query: 40 LHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLR 99
LHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLR
Sbjct: 61 LHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLR 120
Query: 100 VLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSF 159
VLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSF
Sbjct: 121 VLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSF 180
Query: 160 LVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGL 219
LVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGL
Sbjct: 181 LVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGL 240
Query: 220 VTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVA 279
VTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVA
Sbjct: 241 VTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVA 300
Query: 280 VKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRE 339
VKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRE
Sbjct: 301 VKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRE 360
Query: 340 CNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMT 399
CNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMT
Sbjct: 361 CNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMT 420
Query: 400 GDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVY 459
GDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVY
Sbjct: 421 GDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVY 480
Query: 460 DLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEE 519
DLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEE
Sbjct: 481 DLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEE 540
Query: 520 LGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQ 579
LGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQ
Sbjct: 541 LGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQ 600
Query: 580 ASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREM 639
ASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREM
Sbjct: 601 ASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREM 660
Query: 640 ENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGGGG 699
ENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGGGG
Sbjct: 661 ENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGGGG 720
Query: 700 GGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPEQD 759
GGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPEQD
Sbjct: 721 GGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPEQD 780
Query: 760 RMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPR 819
RMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPR
Sbjct: 781 RMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPR 840
Query: 820 GATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGWPS 879
GATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGWPS
Sbjct: 841 GATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGWPS 900
Query: 880 PAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRP 939
PAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRP
Sbjct: 901 PAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRP 960
Query: 940 RRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPISGK 999
RRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPISGK
Sbjct: 961 RRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPISGK 1020
Query: 1000 AGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECADL 1059
AGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECADL
Sbjct: 1021 AGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECADL 1080
Query: 1060 LSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSA 1119
LSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSA
Sbjct: 1081 LSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSA 1140
Query: 1120 AAGVPGTNPVLNNLLSCVQEISDVVQR 1146
AAGVPGTNPVLNNLLSCVQEISDVVQR
Sbjct: 1141 AAGVPGTNPVLNNLLSCVQEISDVVQR 1167
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 2239 bits (5801), Expect = 0.0
Identities = 1109/1109 (100%), Positives = 1109/1109 (100%)
Query: 38 EALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEK 97
EALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEK
Sbjct: 74 EALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEK 133
Query: 98 LRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLING 157
LRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLING
Sbjct: 134 LRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLING 193
Query: 158 SFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVAD 217
SFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVAD
Sbjct: 194 SFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVAD 253
Query: 218 GLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLT 277
GLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLT
Sbjct: 254 GLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLT 313
Query: 278 VAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYL 337
VAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYL
Sbjct: 314 VAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYL 373
Query: 338 RECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRL 397
RECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRL
Sbjct: 374 RECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRL 433
Query: 398 MTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ 457
MTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ
Sbjct: 434 MTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ 493
Query: 458 VYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVA 517
VYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVA
Sbjct: 494 VYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVA 553
Query: 518 EELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRG 577
EELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRG
Sbjct: 554 EELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRG 613
Query: 578 AQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFR 637
AQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFR
Sbjct: 614 AQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFR 673
Query: 638 EMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGG 697
EMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGG
Sbjct: 674 EMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGG 733
Query: 698 GGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPE 757
GGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPE
Sbjct: 734 GGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPE 793
Query: 758 QDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLL 817
QDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLL
Sbjct: 794 QDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLL 853
Query: 818 PRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGW 877
PRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGW
Sbjct: 854 PRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGW 913
Query: 878 PSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKD 937
PSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKD
Sbjct: 914 PSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKD 973
Query: 938 RPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPIS 997
RPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPIS
Sbjct: 974 RPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPIS 1033
Query: 998 GKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECA 1057
GKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECA
Sbjct: 1034 GKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECA 1093
Query: 1058 DLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVS 1117
DLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVS
Sbjct: 1094 DLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVS 1153
Query: 1118 SAAAGVPGTNPVLNNLLSCVQEISDVVQR 1146
SAAAGVPGTNPVLNNLLSCVQEISDVVQR
Sbjct: 1154 SAAAGVPGTNPVLNNLLSCVQEISDVVQR 1182
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 1314 bits (3401), Expect = 0.0
Identities = 651/672 (96%), Positives = 651/672 (96%), Gaps = 21/672 (3%)
Query: 1 MVLGTVLLPPNSYGRDQDTSLCCLCTEASESALPDLT---------------------EA 39
MVLGTVLLPPNSYGRDQDTSLCCLCTEASESALPDLT EA
Sbjct: 1 MVLGTVLLPPNSYGRDQDTSLCCLCTEASESALPDLTDHFASCVEDGFEGDKTGGSSPEA 60
Query: 40 LHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLR 99
LHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLR
Sbjct: 61 LHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLR 120
Query: 100 VLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSF 159
VLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSF
Sbjct: 121 VLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSF 180
Query: 160 LVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGL 219
LVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGL
Sbjct: 181 LVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGL 240
Query: 220 VTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVA 279
VTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVA
Sbjct: 241 VTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVA 300
Query: 280 VKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRE 339
VKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRE
Sbjct: 301 VKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRE 360
Query: 340 CNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMT 399
CNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMT
Sbjct: 361 CNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMT 420
Query: 400 GDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVY 459
GDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVY
Sbjct: 421 GDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVY 480
Query: 460 DLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEE 519
DLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEE
Sbjct: 481 DLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEE 540
Query: 520 LGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQ 579
LGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQ
Sbjct: 541 LGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQ 600
Query: 580 ASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREM 639
ASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREM
Sbjct: 601 ASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREM 660
Query: 640 ENQPHKKYELTG 651
ENQPHKKYELTG
Sbjct: 661 ENQPHKKYELTG 672
Score = 783 bits (2021), Expect = 0.0
Identities = 393/394 (99%), Positives = 394/394 (100%)
Query: 753 SGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERP 812
+GLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERP
Sbjct: 671 TGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERP 730
Query: 813 KAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDG 872
KAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDG
Sbjct: 731 KAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDG 790
Query: 873 EQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTS 932
EQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTS
Sbjct: 791 EQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTS 850
Query: 933 SGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALG 992
SGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALG
Sbjct: 851 SGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALG 910
Query: 993 AVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEA 1052
AVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEA
Sbjct: 911 AVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEA 970
Query: 1053 LLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQ 1112
LLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQ
Sbjct: 971 LLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQ 1030
Query: 1113 ELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR 1146
ELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR
Sbjct: 1031 ELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR 1064
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 1082 bits (2798), Expect = 0.0
Identities = 634/1174 (54%), Positives = 759/1174 (64%), Gaps = 117/1174 (9%)
Query: 29 SESALPDLTEALHRPYGCDVEPQALNEAIRWSSKENLL-GATESDPNLFVALYDFVASGD 87
S S+ L EAL RP D EPQ L+EA RW+SKENLL G +E+DPNLFVALYDFVASGD
Sbjct: 18 SSSSSCYLEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGD 77
Query: 88 NTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAA 147
NTLSITKGEKLRVLGYN NGEW E ++KNGQGWVPSNYITPVNSLEKHSWYHGPVSR+AA
Sbjct: 78 NTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAA 137
Query: 148 EYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAE 207
EYLLSS INGSFLVRESESSPGQ SISLRYEGRVYHYRINT +DGK+YV++ESRF+TLAE
Sbjct: 138 EYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAE 197
Query: 208 LVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVY 267
LVHHHSTVADGL+TTLHYPAPK NKPTVYGVSP +DKWEMERTDITMKHKLGGGQYGEVY
Sbjct: 198 LVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVY 257
Query: 268 VGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEY 327
GVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT EPPFYI+TE+
Sbjct: 258 EGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEF 317
Query: 328 MPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVV 387
M YGNLLDYLRECNR+EV AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENH+V
Sbjct: 318 MTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLV 377
Query: 388 KVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGM 447
KVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYN FSIKSDVWAFGVLLWEIATYGM
Sbjct: 378 KVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGM 437
Query: 448 SPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMF 507
SPYPGIDLSQVY+LLEK YRME+PEGCP KVYELMRACW+W+P+DRPSFAE HQAFETMF
Sbjct: 438 SPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMF 497
Query: 508 HDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSA 567
+SSIS+EV +ELG+ +V L + P LP+KTRT ++ E+++ + +
Sbjct: 498 QESSISDEVEKELGKQGVRGAVSTLL-QAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQ 556
Query: 568 SSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFM--KKRN 625
P + SP LPRK+R L ED E +D+K FS+ + KK+
Sbjct: 557 GESDP----LDHEPAVSPLLPRKERGPPEGGLNED--ERLLPKDKKTNLFSALIKKKKKT 610
Query: 626 APTPPKRSSSFREMENQPHKK--YELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYG 683
APTPPKRSSSFREM+ QP ++ E G S +L +FTP PK
Sbjct: 611 APTPPKRSSSFREMDGQPERRGAGEEEGRDISNGAL------AFTPLDTADPAKSPKPSN 664
Query: 684 GSFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRA-----GKPTASDDT 738
G+ + GG +GF +P L KK+ L + G+ +
Sbjct: 665 GAGVPNGALRESGG---------------SGFRSPHLWKKSSTLTSSRLATGEEEGGGSS 709
Query: 739 SKPFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLP 798
SK F RS S S + G + + ++TLPR+ Q + Q + +
Sbjct: 710 SKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGG--------------- 754
Query: 799 KKSEESAAPSRE--RPKAKLLPRGATALPLR-TPSGDLAITE------KDPPGVGVAGVA 849
KSE+ A P + ++ + RG P R + A E + PG +
Sbjct: 755 HKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLT 814
Query: 850 AAPKGKEKNGGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPAD 909
P ++ G+ E G+ +PA A PV PT+ K PA+
Sbjct: 815 PKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTS---KAGSGAPGGTSKGPAE 871
Query: 910 VQLIGTDSQGNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEE 969
+S+ + K SE + DK + R+KP APPPPP P++
Sbjct: 872 ------ESRVRRHKHSSE---SPGRDKGKLSRLKP--APPPPPA---ASAGKAGGKPSQS 917
Query: 970 PTALTAGQST---------------------SETQEGGKKAALGAVPISGKA---GRPVM 1005
P+ AG++ S+ EG KK L A P A G P+
Sbjct: 918 PSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPIS 977
Query: 1006 PPPQVP--LPTSSISPA-KMANGTA-----GTKVALRKTKQAAEKISADKISKEALLECA 1057
P P VP LP++S + A + TA T+V+LRKT+Q E+I++ I+K +L+
Sbjct: 978 PAP-VPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDST 1036
Query: 1058 DLLSSALT----EPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQE 1113
+ L A++ + +S +++ G L +C YVD I Q RNKFAFREA++KLE +L+E
Sbjct: 1037 EALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRE 1096
Query: 1114 LQVSSAAAGV-PGTNPVLNNLLSCVQEISDVVQR 1146
LQ+ A AG P + LLS V+EISD+VQR
Sbjct: 1097 LQICPATAGSGPAATQDFSKLLSSVKEISDIVQR 1130
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 1080 bits (2794), Expect = 0.0
Identities = 631/1165 (54%), Positives = 755/1165 (64%), Gaps = 117/1165 (10%)
Query: 38 EALHRPYGCDVEPQALNEAIRWSSKENLL-GATESDPNLFVALYDFVASGDNTLSITKGE 96
EAL RP D EPQ L+EA RW+SKENLL G +E+DPNLFVALYDFVASGDNTLSITKGE
Sbjct: 46 EALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGE 105
Query: 97 KLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN 156
KLRVLGYN NGEW E ++KNGQGWVPSNYITPVNSLEKHSWYHGPVSR+AAEYLLSS IN
Sbjct: 106 KLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGIN 165
Query: 157 GSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVA 216
GSFLVRESESSPGQ SISLRYEGRVYHYRINT +DGK+YV++ESRF+TLAELVHHHSTVA
Sbjct: 166 GSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVA 225
Query: 217 DGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSL 276
DGL+TTLHYPAPK NKPTVYGVSP +DKWEMERTDITMKHKLGGGQYGEVY GVWKKYSL
Sbjct: 226 DGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSL 285
Query: 277 TVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDY 336
TVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT EPPFYI+TE+M YGNLLDY
Sbjct: 286 TVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDY 345
Query: 337 LRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR 396
LRECNR+EV AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENH+VKVADFGLSR
Sbjct: 346 LRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSR 405
Query: 397 LMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLS 456
LMTGDTYTAHAGAKFPIKWTAPESLAYN FSIKSDVWAFGVLLWEIATYGMSPYPGIDLS
Sbjct: 406 LMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLS 465
Query: 457 QVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEV 516
QVY+LLEK YRME+PEGCP KVYELMRACW+W+P+DRPSFAE HQAFETMF +SSIS+EV
Sbjct: 466 QVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEV 525
Query: 517 AEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIR 576
+ELG+ +V L + P LP+KTRT ++ E+++ + + P
Sbjct: 526 EKELGKQGVRGAVSTLL-QAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDP---- 580
Query: 577 GAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFM--KKRNAPTPPKRSS 634
+ SP LPRK+R L ED E +D+K FS+ + KK+ APTPPKRSS
Sbjct: 581 LDHEPAVSPLLPRKERGPPEGGLNED--ERLLPKDKKTNLFSALIKKKKKTAPTPPKRSS 638
Query: 635 SFREMENQPHKK--YELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLC 692
SFREM+ QP ++ E G S +L +FTP PK G+
Sbjct: 639 SFREMDGQPERRGAGEEEGRDISNGAL------AFTPLDTADPAKSPKPSNGAGVPNGAL 692
Query: 693 NDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRA-----GKPTASDDTSKPFPRSNS 747
+ GG +GF +P L KK+ L + G+ +SK F RS S
Sbjct: 693 RESGG---------------SGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCS 737
Query: 748 TSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAP 807
S + G + + ++TLPR+ Q + Q + + KSE+ A P
Sbjct: 738 ASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGG---------------HKSEKPALP 782
Query: 808 SRE--RPKAKLLPRGATALPLR-TPSGDLAITE------KDPPGVGVAGVAAAPKGKEKN 858
+ ++ + RG P R + A E + PG + P ++
Sbjct: 783 RKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVT 842
Query: 859 GGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQ 918
G+ E G+ +PA A PV PT+ K PA+ +S+
Sbjct: 843 VAPASGLPHKEEAGKGSALGTPAAAEPVTPTS---KAGSGAPGGTSKGPAE------ESR 893
Query: 919 GNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQS 978
+ K SE + DK + R+KP APPPPP P++ P+ AG++
Sbjct: 894 VRRHKHSSE---SPGRDKGKLSRLKP--APPPPPA---ASAGKAGGKPSQSPSQEAAGEA 945
Query: 979 T---------------------SETQEGGKKAALGAVPISGKA---GRPVMPPPQVP--L 1012
S+ EG KK L A P A G P+ P P VP L
Sbjct: 946 VLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAP-VPSTL 1004
Query: 1013 PTSSISPA-KMANGTA-----GTKVALRKTKQAAEKISADKISKEALLECADLLSSALT- 1065
P++S + A + TA T+V+LRKT+Q E+I++ I+K +L+ + L A++
Sbjct: 1005 PSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISR 1064
Query: 1066 ---EPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSAAAG 1122
+ +S +++ G L +C YVD I Q RNKFAFREA++KLE +L+ELQ+ A AG
Sbjct: 1065 NSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQICPATAG 1124
Query: 1123 V-PGTNPVLNNLLSCVQEISDVVQR 1146
P + LLS V+EISD+VQR
Sbjct: 1125 SGPAATQDFSKLLSSVKEISDIVQR 1149
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 983 bits (2542), Expect = 0.0
Identities = 477/477 (100%), Positives = 477/477 (100%)
Query: 38 EALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEK 97
EALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEK
Sbjct: 53 EALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEK 112
Query: 98 LRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLING 157
LRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLING
Sbjct: 113 LRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLING 172
Query: 158 SFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVAD 217
SFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVAD
Sbjct: 173 SFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVAD 232
Query: 218 GLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLT 277
GLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLT
Sbjct: 233 GLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLT 292
Query: 278 VAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYL 337
VAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYL
Sbjct: 293 VAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYL 352
Query: 338 RECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRL 397
RECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRL
Sbjct: 353 RECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRL 412
Query: 398 MTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ 457
MTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ
Sbjct: 413 MTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ 472
Query: 458 VYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISE 514
VYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISE
Sbjct: 473 VYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISE 529
>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
Length = 534
Score = 371 bits (952), Expect = e-102
Identities = 201/455 (44%), Positives = 281/455 (61%), Gaps = 15/455 (3%)
Query: 75 LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSL 132
LFVALYD+ A ++ LS KGEK ++L ++ G+W E RS G++PSNY+ PV+S+
Sbjct: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSE-GDWWEARSLTTGETGYIPSNYVAPVDSI 144
Query: 133 EKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR-----YEGRVYHYR 185
+ WY G + R AE L S N G+FL+RESE++ G S+S+R V HY+
Sbjct: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK 204
Query: 186 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKW 245
I +G Y+T ++F TL +LV H+S ADGL L A C P G++ D W
Sbjct: 205 IRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCT-PQTSGLAK--DAW 261
Query: 246 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 305
E+ R + ++ KLG G + EV++G W + VA+KTLK TM E FL+EA +MK++KH
Sbjct: 262 EVARRSLCLEKKLGQGCFAEVWLGTWNG-NTKVAIKTLKPGTMSPESFLEEAQIMKKLKH 320
Query: 306 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 365
LVQL V + E P YIVTEYM G+LLD+L++ + L+ MA Q+++ M Y+E
Sbjct: 321 DKLVQLYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIE 379
Query: 366 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 425
+ N+IHRDL + N LVG + K+ADFGL+RL+ + YTA GAKFPIKWTAPE+ Y
Sbjct: 380 RMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 439
Query: 426 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 485
F+IKSDVW+FG+LL E+ T G PYPG++ +V + +E+GYRM P+ CP ++ELM C
Sbjct: 440 FTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHC 499
Query: 486 WKWSPADRPSFAETHQAFETMFHDSSISEEVAEEL 520
WK P +RP+F E F + + E L
Sbjct: 500 WKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 534
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 370 bits (949), Expect = e-102
Identities = 198/454 (43%), Positives = 273/454 (60%), Gaps = 16/454 (3%)
Query: 76 FVALYDFVASGDNTLSITKGEKLRVLGYNQNGEW--------SEVRSKNGQGWVPSNYIT 127
FVAL+D+ A LS G+KL+VL G W + S+ QG++PSNY+
Sbjct: 47 FVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVA 106
Query: 128 PVNSLEKHSWYHGPVSRSAAE--YLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYR 185
SL+ W+ G + RS AE L S GSFL+RESES G+ S+S+ V HYR
Sbjct: 107 EDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYR 166
Query: 186 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVS-PIHDK 244
I +G ++T FSTL E V H++ +DGL L P K P + +S D+
Sbjct: 167 IKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQ 226
Query: 245 WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK 304
WE++R I + +LG GQ+GEV+ G+W + VAVKTLK +M+ +FL+EA +MK ++
Sbjct: 227 WEIDRNSIQLLKRLGSGQFGEVWEGLWNN-TTPVAVKTLKPGSMDPNDFLREAQIMKNLR 285
Query: 305 HPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYL 364
HP L+QL VCTLE P YI+TE M +G+L +YL+ ++ + MA Q++S M YL
Sbjct: 286 HPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYL 345
Query: 365 EKKNFIHRDLAARNCLVGENHVVKVADFGLSRLM---TGDTYTAHAGAKFPIKWTAPESL 421
E +N+IHRDLAARN LVGE+++ KVADFGL+R+ D Y + K P+KWTAPE++
Sbjct: 346 ESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAI 405
Query: 422 AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYEL 481
N FSIKSDVW+FG+LL+EI TYG PY G+ +QV +L + YR+ QP CP + Y +
Sbjct: 406 RSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNI 465
Query: 482 MRACWKWSPADRPSFAETHQAFETMFH-DSSISE 514
M CW P +RP+F E F DSS S+
Sbjct: 466 MLECWNAEPKERPTFETLRWKLEDYFETDSSYSD 499
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 369 bits (946), Expect = e-101
Identities = 201/456 (44%), Positives = 281/456 (61%), Gaps = 14/456 (3%)
Query: 75 LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSL 132
LFVALYD+ A ++ LS KGEK ++L ++ G+W E RS G++PSNY+ PV+S+
Sbjct: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSE-GDWWEARSLTTGETGYIPSNYVAPVDSI 144
Query: 133 EKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR-----YEGRVYHYR 185
+ WY G + R AE L S N G+FL+RESE++ G S+S+R V HY+
Sbjct: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK 204
Query: 186 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVS-PIHDK 244
I +G Y+T ++F TL +LV H+S A GL L P K P + +S D
Sbjct: 205 IRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHK-GMPRLTDLSVKTKDV 263
Query: 245 WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK 304
WE+ R + + +LG GQ+GEV++G W + VA+KTLK TM E FL+EA +MK++K
Sbjct: 264 WEIPRESLQLIKRLGNGQFGEVWMGTWNG-NTKVAIKTLKPGTMSPESFLEEAQIMKKLK 322
Query: 305 HPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYL 364
H LVQL V + E P YIVTEYM G+LLD+L++ + L+ MA Q+++ M Y+
Sbjct: 323 HDKLVQLYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYI 381
Query: 365 EKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYN 424
E+ N+IHRDL + N LVG + K+ADFGL+RL+ + YTA GAKFPIKWTAPE+ Y
Sbjct: 382 ERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 441
Query: 425 TFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRA 484
F+IKSDVW+FG+LL E+ T G PYPG++ +V + +E+GYRM P+ CP ++ELM
Sbjct: 442 RFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIH 501
Query: 485 CWKWSPADRPSFAETHQAFETMFHDSSISEEVAEEL 520
CWK P +RP+F E F + + E L
Sbjct: 502 CWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 537
>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
Length = 543
Score = 368 bits (944), Expect = e-101
Identities = 202/455 (44%), Positives = 279/455 (61%), Gaps = 15/455 (3%)
Query: 75 LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSL 132
+FVALYD+ A LS KGE+ +++ N G+W E RS G++PSNY+ P +S+
Sbjct: 95 IFVALYDYEARTTEDLSFKKGERFQIIN-NTEGDWWEARSIATGKNGYIPSNYVAPADSI 153
Query: 133 EKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR-----YEGRVYHYR 185
+ WY G + R AE LL + N G FLVRESE++ G S+S+R V HY+
Sbjct: 154 QAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYK 213
Query: 186 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKW 245
I +G Y+T ++F TL +LV H++ ADGL L P KP G++ D W
Sbjct: 214 IRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTV-KPQTQGLAK--DAW 270
Query: 246 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 305
E+ R + ++ KLG G +GEV++G W + VA+KTLK TM E FL+EA +MK+++H
Sbjct: 271 EIPRESLRLEVKLGQGCFGEVWMGTWNG-TTKVAIKTLKPGTMMPEAFLQEAQIMKKLRH 329
Query: 306 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 365
LV L V + E P YIVTE+M G+LLD+L+E + + + L+ MA QI+ M Y+E
Sbjct: 330 DKLVPLYAVVS-EEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIE 388
Query: 366 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 425
+ N+IHRDL A N LVGEN V K+ADFGL+RL+ + YTA GAKFPIKWTAPE+ Y
Sbjct: 389 RMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 448
Query: 426 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 485
F+IKSDVW+FG+L E+ T G PYPG+ +V + +E+GYRM P+GCP ++ELM C
Sbjct: 449 FTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLC 508
Query: 486 WKWSPADRPSFAETHQAFETMFHDSSISEEVAEEL 520
WK P +RP+F E F + + E L
Sbjct: 509 WKKDPDERPTFEYIQSFLEDYFTATEPQYQPGENL 543
>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 364 bits (935), Expect = e-100
Identities = 206/489 (42%), Positives = 288/489 (58%), Gaps = 23/489 (4%)
Query: 34 PDLTEA------LHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGD 87
PD T+A H P + QA+N S + G + LF+ALYD+ A +
Sbjct: 36 PDPTKARPASSFAHIPNYSNFSSQAINPGFLDSG--TIRGVSGIGVTLFIALYDYEARTE 93
Query: 88 NTLSITKGEKLRVLGYNQNGEWSEVRSKNG--QGWVPSNYITPVNSLEKHSWYHGPVSRS 145
+ L+ TKGEK +L N G+W E RS + G +PSNY+ PV+S++ WY G + R
Sbjct: 94 DDLTFTKGEKFHILN-NTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRK 152
Query: 146 AAEYLLSSLIN--GSFLVRESESSPGQLSISLR-----YEGRVYHYRINTTADGKVYVTA 198
AE L S N G+FL+RESE++ G S+S+R V HY+I G Y+T
Sbjct: 153 DAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITT 212
Query: 199 ESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKL 258
+F+++ ELV H+ V DGL L P KP G++ D WE+ R+ IT++ +L
Sbjct: 213 RVQFNSVQELVQHYMEVNDGLCNLLIAPCT-IMKPQTLGLAK--DAWEISRSSITLERRL 269
Query: 259 GGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLE 318
G G +G+V++G W S VAVKTLK TM + FL+EA VMK ++H LVQL V + E
Sbjct: 270 GTGCFGDVWLGTWNG-STKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVS-E 327
Query: 319 PPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARN 378
P YIVTE+M +G+LLD+L+ +++ L+ MA Q++ M Y+E+ N+IHRDL A N
Sbjct: 328 EPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAAN 387
Query: 379 CLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVL 438
LVGE K+ADFGL+RL+ D Y G+KFPIKWTAPE+ + F+IKSDVW+FG+L
Sbjct: 388 ILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGIL 447
Query: 439 LWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAE 498
L E+ T G PYPG++ +V + +E+GY M P GCP +YE M W+ P +RP+F
Sbjct: 448 LTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEY 507
Query: 499 THQAFETMF 507
E F
Sbjct: 508 LQSFLEDYF 516
>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 364 bits (935), Expect = e-100
Identities = 206/489 (42%), Positives = 288/489 (58%), Gaps = 23/489 (4%)
Query: 34 PDLTEA------LHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGD 87
PD T+A H P + QA+N S + G + LF+ALYD+ A +
Sbjct: 36 PDPTKARPASSFAHIPNYSNFSSQAINPGFLDSG--TIRGVSGIGVTLFIALYDYEARTE 93
Query: 88 NTLSITKGEKLRVLGYNQNGEWSEVRSKNG--QGWVPSNYITPVNSLEKHSWYHGPVSRS 145
+ L+ TKGEK +L N G+W E RS + G +PSNY+ PV+S++ WY G + R
Sbjct: 94 DDLTFTKGEKFHILN-NTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRK 152
Query: 146 AAEYLLSSLIN--GSFLVRESESSPGQLSISLR-----YEGRVYHYRINTTADGKVYVTA 198
AE L S N G+FL+RESE++ G S+S+R V HY+I G Y+T
Sbjct: 153 DAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITT 212
Query: 199 ESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKL 258
+F+++ ELV H+ V DGL L P KP G++ D WE+ R+ IT++ +L
Sbjct: 213 RVQFNSVQELVQHYMEVNDGLCNLLIAPCT-IMKPQTLGLAK--DAWEISRSSITLERRL 269
Query: 259 GGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLE 318
G G +G+V++G W S VAVKTLK TM + FL+EA VMK ++H LVQL V + E
Sbjct: 270 GTGCFGDVWLGTWNG-STKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVS-E 327
Query: 319 PPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARN 378
P YIVTE+M +G+LLD+L+ +++ L+ MA Q++ M Y+E+ N+IHRDL A N
Sbjct: 328 EPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAAN 387
Query: 379 CLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVL 438
LVGE K+ADFGL+RL+ D Y G+KFPIKWTAPE+ + F+IKSDVW+FG+L
Sbjct: 388 ILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGIL 447
Query: 439 LWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAE 498
L E+ T G PYPG++ +V + +E+GY M P GCP +YE M W+ P +RP+F
Sbjct: 448 LTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEY 507
Query: 499 THQAFETMF 507
E F
Sbjct: 508 LQSFLEDYF 516
>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 364 bits (935), Expect = e-100
Identities = 206/489 (42%), Positives = 288/489 (58%), Gaps = 23/489 (4%)
Query: 34 PDLTEA------LHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGD 87
PD T+A H P + QA+N S + G + LF+ALYD+ A +
Sbjct: 36 PDPTKARPASSFAHIPNYSNFSSQAINPGFLDSG--TIRGVSGIGVTLFIALYDYEARTE 93
Query: 88 NTLSITKGEKLRVLGYNQNGEWSEVRSKNG--QGWVPSNYITPVNSLEKHSWYHGPVSRS 145
+ L+ TKGEK +L N G+W E RS + G +PSNY+ PV+S++ WY G + R
Sbjct: 94 DDLTFTKGEKFHILN-NTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRK 152
Query: 146 AAEYLLSSLIN--GSFLVRESESSPGQLSISLR-----YEGRVYHYRINTTADGKVYVTA 198
AE L S N G+FL+RESE++ G S+S+R V HY+I G Y+T
Sbjct: 153 DAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITT 212
Query: 199 ESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKL 258
+F+++ ELV H+ V DGL L P KP G++ D WE+ R+ IT++ +L
Sbjct: 213 RVQFNSVQELVQHYMEVNDGLCNLLIAPCT-IMKPQTLGLAK--DAWEISRSSITLERRL 269
Query: 259 GGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLE 318
G G +G+V++G W S VAVKTLK TM + FL+EA VMK ++H LVQL V + E
Sbjct: 270 GTGCFGDVWLGTWNG-STKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVS-E 327
Query: 319 PPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARN 378
P YIVTE+M +G+LLD+L+ +++ L+ MA Q++ M Y+E+ N+IHRDL A N
Sbjct: 328 EPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAAN 387
Query: 379 CLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVL 438
LVGE K+ADFGL+RL+ D Y G+KFPIKWTAPE+ + F+IKSDVW+FG+L
Sbjct: 388 ILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGIL 447
Query: 439 LWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAE 498
L E+ T G PYPG++ +V + +E+GY M P GCP +YE M W+ P +RP+F
Sbjct: 448 LTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEY 507
Query: 499 THQAFETMF 507
E F
Sbjct: 508 LQSFLEDYF 516
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 359 bits (922), Expect = 7e-99
Identities = 198/453 (43%), Positives = 280/453 (61%), Gaps = 13/453 (2%)
Query: 76 FVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ-GWVPSNYITPVNSLEK 134
FVALYD+ + + LS KGE+L+++ + W GQ G++PSNY+ P +S++
Sbjct: 89 FVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQA 148
Query: 135 HSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISL----RYEG-RVYHYRIN 187
WY G ++R +E LL + N G+FLVRESE++ G +S+ +G V HY+I
Sbjct: 149 EEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIR 208
Query: 188 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEM 247
G Y+T+ ++F++L +LV ++S ADGL L P +KP G++ D WE+
Sbjct: 209 KLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT-SKPQTQGLAK--DAWEI 265
Query: 248 ERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPN 307
R + ++ KLG G +GEV++G W + VA+KTLK TM E FL+EA VMK+++H
Sbjct: 266 PRESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEK 324
Query: 308 LVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK 367
LVQL V + E P YIVTEYM G+LLD+L+ + + L+ MA QI+S M Y+E+
Sbjct: 325 LVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383
Query: 368 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS 427
N++HRDL A N LVGEN V KVADFGL+RL+ + YTA GAKFPIKWTAPE+ Y F+
Sbjct: 384 NYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 443
Query: 428 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK 487
IKSDVW+FG+LL E+ T G PYPG+ +V D +E+GYRM P CP +++LM CW+
Sbjct: 444 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWR 503
Query: 488 WSPADRPSFAETHQAFETMFHDSSISEEVAEEL 520
P +RP+F E F + + E L
Sbjct: 504 KEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 359 bits (922), Expect = 7e-99
Identities = 198/453 (43%), Positives = 280/453 (61%), Gaps = 13/453 (2%)
Query: 76 FVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ-GWVPSNYITPVNSLEK 134
FVALYD+ + + LS KGE+L+++ + W GQ G++PSNY+ P +S++
Sbjct: 89 FVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQA 148
Query: 135 HSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISL----RYEG-RVYHYRIN 187
WY G ++R +E LL + N G+FLVRESE++ G +S+ +G V HY+I
Sbjct: 149 EEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIR 208
Query: 188 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEM 247
G Y+T+ ++F++L +LV ++S ADGL L P +KP G++ D WE+
Sbjct: 209 KLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT-SKPQTQGLAK--DAWEI 265
Query: 248 ERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPN 307
R + ++ KLG G +GEV++G W + VA+KTLK TM E FL+EA VMK+++H
Sbjct: 266 PRESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEK 324
Query: 308 LVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK 367
LVQL V + E P YIVTEYM G+LLD+L+ + + L+ MA QI+S M Y+E+
Sbjct: 325 LVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383
Query: 368 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS 427
N++HRDL A N LVGEN V KVADFGL+RL+ + YTA GAKFPIKWTAPE+ Y F+
Sbjct: 384 NYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 443
Query: 428 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK 487
IKSDVW+FG+LL E+ T G PYPG+ +V D +E+GYRM P CP +++LM CW+
Sbjct: 444 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWR 503
Query: 488 WSPADRPSFAETHQAFETMFHDSSISEEVAEEL 520
P +RP+F E F + + E L
Sbjct: 504 KEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 358 bits (920), Expect = 1e-98
Identities = 198/451 (43%), Positives = 281/451 (62%), Gaps = 21/451 (4%)
Query: 68 ATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNY 125
A+ NL +AL+ + S D L KGE+LR+L Q+GEW + +S +G++P N+
Sbjct: 58 ASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRIL--EQSGEWWKAQSLTTGQEGFIPFNF 115
Query: 126 ITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR----YEG 179
+ NSLE W+ +SR AE L + N GSFL+RESES+ G S+S+R +G
Sbjct: 116 VAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQG 175
Query: 180 RVY-HYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAP--KCNKPTVY 236
V HY+I +G Y++ F L ELV H++ +DGL T L P K KP
Sbjct: 176 EVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWW- 234
Query: 237 GVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKE 296
D+WE+ R + + +LG GQ+GEV++G + ++ VAVK+LK+ +M + FL E
Sbjct: 235 -----EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHT-KVAVKSLKQGSMSPDAFLAE 288
Query: 297 AAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQ 356
A +MK+++H LV+L V T EP YI+TEYM G+L+D+L+ + ++T LL MA Q
Sbjct: 289 ANLMKQLQHQRLVRLYAVVTQEP-IYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQ 347
Query: 357 ISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWT 416
I+ M ++E++N+IHRDL A N LV + K+ADFGL+RL+ + YTA GAKFPIKWT
Sbjct: 348 IAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWT 407
Query: 417 APESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPP 476
APE++ Y TF+IKSDVW+FG+LL EI T+G PYPG+ +V LE+GYRM +P+ CP
Sbjct: 408 APEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPE 467
Query: 477 KVYELMRACWKWSPADRPSFAETHQAFETMF 507
++Y+LMR CWK P DRP+F E F
Sbjct: 468 ELYQLMRLCWKERPEDRPTFDYLRSVLEDFF 498
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 358 bits (920), Expect = 1e-98
Identities = 198/451 (43%), Positives = 281/451 (62%), Gaps = 21/451 (4%)
Query: 68 ATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNY 125
A+ NL +AL+ + S D L KGE+LR+L Q+GEW + +S +G++P N+
Sbjct: 58 ASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRIL--EQSGEWWKAQSLTTGQEGFIPFNF 115
Query: 126 ITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR----YEG 179
+ NSLE W+ +SR AE L + N GSFL+RESES+ G S+S+R +G
Sbjct: 116 VAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQG 175
Query: 180 RVY-HYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAP--KCNKPTVY 236
V HY+I +G Y++ F L ELV H++ +DGL T L P K KP
Sbjct: 176 EVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWW- 234
Query: 237 GVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKE 296
D+WE+ R + + +LG GQ+GEV++G + ++ VAVK+LK+ +M + FL E
Sbjct: 235 -----EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHT-KVAVKSLKQGSMSPDAFLAE 288
Query: 297 AAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQ 356
A +MK+++H LV+L V T EP YI+TEYM G+L+D+L+ + ++T LL MA Q
Sbjct: 289 ANLMKQLQHQRLVRLYAVVTQEP-IYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQ 347
Query: 357 ISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWT 416
I+ M ++E++N+IHRDL A N LV + K+ADFGL+RL+ + YTA GAKFPIKWT
Sbjct: 348 IAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWT 407
Query: 417 APESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPP 476
APE++ Y TF+IKSDVW+FG+LL EI T+G PYPG+ +V LE+GYRM +P+ CP
Sbjct: 408 APEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPE 467
Query: 477 KVYELMRACWKWSPADRPSFAETHQAFETMF 507
++Y+LMR CWK P DRP+F E F
Sbjct: 468 ELYQLMRLCWKERPEDRPTFDYLRSVLEDFF 498
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 355 bits (910), Expect = 2e-97
Identities = 199/450 (44%), Positives = 281/450 (62%), Gaps = 23/450 (5%)
Query: 60 SSKENLLGATE--SDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--K 115
S N G E S+ + VALYD+ A LS KG+++ VL ++GEW + RS
Sbjct: 65 SHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVL--EESGEWWKARSLAT 122
Query: 116 NGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSI 173
+G++PSNY+ V+SLE W+ +SR AE L + N GSF++R+SE++ G S+
Sbjct: 123 RKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSL 182
Query: 174 SLR-YEGR----VYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYP-- 226
S+R Y+ R V HY+I T +G Y++ S FSTL ELV H+ DGL L P
Sbjct: 183 SVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCM 242
Query: 227 APKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKED 286
+ K KP D WE+ R + ++ KLG GQ+GEV++ + K++ VAVKT+K
Sbjct: 243 SSKPQKPWE------KDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHT-KVAVKTMKPG 295
Query: 287 TMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVT 346
+M VE FL EA VMK ++H LV+L V T EP YI+TE+M G+LLD+L+ +
Sbjct: 296 SMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEP-IYIITEFMAKGSLLDFLKSDEGSKQP 354
Query: 347 AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAH 406
L+ + QI+ M ++E++N+IHRDL A N LV + V K+ADFGL+R++ + YTA
Sbjct: 355 LPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAR 414
Query: 407 AGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGY 466
GAKFPIKWTAPE++ + +F+IKSDVW+FG+LL EI TYG PYPG+ +V LE+GY
Sbjct: 415 EGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGY 474
Query: 467 RMEQPEGCPPKVYELMRACWKWSPADRPSF 496
RM +PE CP ++Y +M CWK P +RP+F
Sbjct: 475 RMPRPENCPEELYNIMMRCWKNRPEERPTF 504
>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform B [Homo sapiens]
Length = 491
Score = 348 bits (893), Expect = 2e-95
Identities = 190/463 (41%), Positives = 281/463 (60%), Gaps = 20/463 (4%)
Query: 45 GCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYN 104
G D++ Q + E+ + E ++ VALY + + LS KGEK++VL
Sbjct: 16 GVDLKTQPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVL--E 73
Query: 105 QNGEWSEVRS--KNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFL 160
++GEW + +S +G++PSNY+ +N+LE W+ ++R AE L + N G+FL
Sbjct: 74 EHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFL 133
Query: 161 VRESESSPGQLSISLRYEGRVY-----HYRINTTADGKVYVTAESRFSTLAELVHHHSTV 215
+RESE+ G S+S+R V+ HY+I + +G Y++ F +++++ H+
Sbjct: 134 IRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQ 193
Query: 216 ADGLVTTLHYP--APKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKK 273
ADGL L +PK KP D WE+ R I + +LG GQ+GEV++G +
Sbjct: 194 ADGLCRRLEKACISPKPQKPWD------KDAWEIPRESIKLVKRLGAGQFGEVWMGYYNN 247
Query: 274 YSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNL 333
S VAVKTLK TM V+ FL+EA +MK ++H LV+L V T E P YI+TEYM G+L
Sbjct: 248 -STKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSL 306
Query: 334 LDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFG 393
LD+L+ +V L+ + QI+ M Y+E+KN+IHRDL A N LV E+ + K+ADFG
Sbjct: 307 LDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFG 366
Query: 394 LSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGI 453
L+R++ + YTA GAKFPIKWTAPE++ + F+IKSDVW+FG+LL+EI TYG PYPG
Sbjct: 367 LARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGR 426
Query: 454 DLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF 496
+ V L +GYRM + E CP ++Y++M+ CWK +RP+F
Sbjct: 427 TNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTF 469
>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform A [Homo sapiens]
Length = 512
Score = 347 bits (890), Expect = 4e-95
Identities = 186/438 (42%), Positives = 272/438 (62%), Gaps = 20/438 (4%)
Query: 70 ESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYIT 127
E ++ VALY + + LS KGEK++VL ++GEW + +S +G++PSNY+
Sbjct: 62 EEQGDIVVALYPYDGIHPDDLSFKKGEKMKVL--EEHGEWWKAKSLLTKKEGFIPSNYVA 119
Query: 128 PVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYEGRVY--- 182
+N+LE W+ ++R AE L + N G+FL+RESE+ G S+S+R V+
Sbjct: 120 KLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDV 179
Query: 183 --HYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYP--APKCNKPTVYGV 238
HY+I + +G Y++ F +++++ H+ ADGL L +PK KP
Sbjct: 180 IKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWD--- 236
Query: 239 SPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAA 298
D WE+ R I + +LG GQ+GEV++G + S VAVKTLK TM V+ FL+EA
Sbjct: 237 ---KDAWEIPRESIKLVKRLGAGQFGEVWMGYYNN-STKVAVKTLKPGTMSVQAFLEEAN 292
Query: 299 VMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQIS 358
+MK ++H LV+L V T E P YI+TEYM G+LLD+L+ +V L+ + QI+
Sbjct: 293 LMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIA 352
Query: 359 SAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAP 418
M Y+E+KN+IHRDL A N LV E+ + K+ADFGL+R++ + YTA GAKFPIKWTAP
Sbjct: 353 EGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAP 412
Query: 419 ESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKV 478
E++ + F+IKSDVW+FG+LL+EI TYG PYPG + V L +GYRM + E CP ++
Sbjct: 413 EAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDEL 472
Query: 479 YELMRACWKWSPADRPSF 496
Y++M+ CWK +RP+F
Sbjct: 473 YDIMKMCWKEKAEERPTF 490
>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
Length = 505
Score = 344 bits (883), Expect = 2e-94
Identities = 195/447 (43%), Positives = 270/447 (60%), Gaps = 18/447 (4%)
Query: 70 ESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYIT 127
+ D + VALYD+ A D L + KGEKL+VL G+W RS +G+VPSN++
Sbjct: 57 DEDKHFVVALYDYTAMNDRDLQMLKGEKLQVL--KGTGDWWLARSLVTGREGYVPSNFVA 114
Query: 128 PVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR---YEGR-V 181
V SLE W+ R AE L + IN GSFL+RESE++ G S+S++ +G +
Sbjct: 115 RVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELI 174
Query: 182 YHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPI 241
HY+I +G Y++ F +L LV H+S DGL L P C +P
Sbjct: 175 KHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLP---CVRPAPQNPWA- 230
Query: 242 HDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMK 301
D+WE+ R + + KLG GQ+GEV++G +K ++ VA+KTLKE TM E FL EA VMK
Sbjct: 231 QDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKN-NMKVAIKTLKEGTMSPEAFLGEANVMK 289
Query: 302 EIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAM 361
++H LV+L V T EP YIVTEYM G LLD+L+ ++ L+ M+ QI+ M
Sbjct: 290 ALQHERLVRLYAVVTKEP-IYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGM 348
Query: 362 EYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL 421
Y+E+ N IHRDL A N LV E K+ADFGL+R++ + YTA GAKFPIKWTAPE++
Sbjct: 349 AYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSE-YTAQEGAKFPIKWTAPEAI 407
Query: 422 AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYE- 480
+ F+IK+DVW+FGVLL E+ TYG PYPG+ +V LE+GYRM +P+ CPP++Y
Sbjct: 408 HFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRG 467
Query: 481 LMRACWKWSPADRPSFAETHQAFETMF 507
++ CW+ P +RP+F E +
Sbjct: 468 VIAECWRSRPEERPTFEFLQSVLEDFY 494
>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
Length = 631
Score = 332 bits (851), Expect = 1e-90
Identities = 185/443 (41%), Positives = 272/443 (61%), Gaps = 20/443 (4%)
Query: 70 ESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYIT- 127
++ + VA+YDF A+ + L + +G++ +L N + W R K G +G++PSNY+T
Sbjct: 178 DNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKN-DVHWWRARDKYGNEGYIPSNYVTG 236
Query: 128 -PVNSLEKHSWYHGPVSRSAAEYLLSSLIN-GSFLVRESESSPGQLSISL--RYEG---- 179
N+L+++ WY ++RS AE LL S G F+VR+S S PG ++SL ++ G
Sbjct: 237 KKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSS 295
Query: 180 --RVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNK--PTV 235
R YH + TT+ K Y+ + F ++ E++ +H A GLVT L YP K PT
Sbjct: 296 GFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTT 355
Query: 236 YGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLK 295
G S ++KWE+ +++T +LG G +G V +G W+ VA+K ++E M E+F++
Sbjct: 356 AGFS--YEKWEINPSELTFMRELGSGLFGVVRLGKWRA-QYKVAIKAIREGAMCEEDFIE 412
Query: 296 EAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMAT 355
EA VM ++ HP LVQL GVCT + P YIVTE+M G LL++LR+ + + VLL M
Sbjct: 413 EAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQ-RQGHFSRDVLLSMCQ 471
Query: 356 QISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKW 415
+ MEYLE+ +FIHRDLAARNCLV E VVKV+DFG++R + D YT+ +GAKFP+KW
Sbjct: 472 DVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKW 531
Query: 416 TAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCP 475
PE Y+ FS KSDVW+FGVL+WE+ T G P+ +V ++ +G+R+ QP+
Sbjct: 532 CPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLAS 591
Query: 476 PKVYELMRACWKWSPADRPSFAE 498
VYE+M CW+ P RPSF +
Sbjct: 592 NYVYEVMLRCWQEKPEGRPSFED 614
>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
Length = 659
Score = 331 bits (848), Expect = 3e-90
Identities = 182/431 (42%), Positives = 261/431 (60%), Gaps = 17/431 (3%)
Query: 77 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ-GWVPSNYITPV-NSLEK 134
VALYD++ N L + KG++ +L N W R KNGQ G++PSNY+T +S+E
Sbjct: 220 VALYDYMPMNANDLQLRKGDEYFILE-ESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEM 278
Query: 135 HSWYHGPVSRSAAEYLLSSL-INGSFLVRESESSPGQLSISLRY------EGRVYHYRIN 187
+ WY ++RS AE LL G F+VR+S S G+ ++S+ +G + HY +
Sbjct: 279 YEWYSKHMTRSQAEQLLKQEGKEGGFIVRDS-SKAGKYTVSVFAKSTGDPQGVIRHYVVC 337
Query: 188 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNK--PTVYGVSPIHDKW 245
+T + Y+ + FST+ EL+++H + GL++ L YP + NK P+ G+ + W
Sbjct: 338 STPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLG--YGSW 395
Query: 246 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 305
E++ D+T +LG GQ+G V G W+ VA+K +KE +M +EF++EA VM + H
Sbjct: 396 EIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIKEGSMSEDEFIEEAKVMMNLSH 454
Query: 306 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 365
LVQL GVCT + P +I+TEYM G LL+YLRE R LL M + AMEYLE
Sbjct: 455 EKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREM-RHRFQTQQLLEMCKDVCEAMEYLE 513
Query: 366 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 425
K F+HRDLAARNCLV + VVKV+DFGLSR + D YT+ G+KFP++W+ PE L Y+
Sbjct: 514 SKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSK 573
Query: 426 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 485
FS KSD+WAFGVL+WEI + G PY S+ + + +G R+ +P KVY +M +C
Sbjct: 574 FSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSC 633
Query: 486 WKWSPADRPSF 496
W +RP+F
Sbjct: 634 WHEKADERPTF 644
>gi|148596974 TXK tyrosine kinase [Homo sapiens]
Length = 527
Score = 322 bits (826), Expect = 1e-87
Identities = 189/522 (36%), Positives = 294/522 (56%), Gaps = 36/522 (6%)
Query: 11 NSYGRDQDTSLCCLCTE------------ASESALPDLTEALHRPYGCDV--EPQALNEA 56
+SY Q CC C +++ LP+ RP+ + + Q+
Sbjct: 4 SSYNTIQSVFCCCCCCSVQKRQMRTQISLSTDEELPEKYTQRRRPWLSQLSNKKQSNTGR 63
Query: 57 IRWSSKENL--LGATE-SDPNLFV-ALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEV 112
++ S ++ L L +E ++ + V ALYDF+ L++ + E+ +L N W +
Sbjct: 64 VQPSKRKPLPPLPPSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILE-KYNPHWWKA 122
Query: 113 RSKNG-QGWVPSNYITP--VNSLEKHSWYHGPVSRSAAEYLL-SSLINGSFLVRESESSP 168
R + G +G +PSNY+T + +LE + WYH ++R+ AE+LL G+F+VR+S
Sbjct: 123 RDRLGNEGLIPSNYVTENKITNLEIYEWYHRNITRNQAEHLLRQESKEGAFIVRDSRHL- 181
Query: 169 GQLSISL------RYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTT 222
G +IS+ E + HY+I G+ YV F ++ EL+ +H A GL+T
Sbjct: 182 GSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTR 241
Query: 223 LHYPAPKCNK--PTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAV 280
L YP P G S ++KWE++ +++ ++G GQ+G V++G W+ + + VA+
Sbjct: 242 LRYPVGLMGSCLPATAGFS--YEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSH-IQVAI 298
Query: 281 KTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLREC 340
K + E +M E+F++EA VM ++ H LVQL GVC P YIVTE+M G LL+YLRE
Sbjct: 299 KAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRE- 357
Query: 341 NREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTG 400
N+ ++ +LL + I MEYLE+ +IHRDLAARNCLV +VK++DFG++R +
Sbjct: 358 NKGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLD 417
Query: 401 DTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYD 460
D Y + GAKFPIKW+ PE +N +S KSDVW+FGVL+WE+ T G P+ QV +
Sbjct: 418 DEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVE 477
Query: 461 LLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQA 502
+ +G+R+ +P P +YE+M +CW P RP+FAE +A
Sbjct: 478 AISEGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRA 519
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 316 bits (810), Expect = 7e-86
Identities = 178/437 (40%), Positives = 257/437 (58%), Gaps = 19/437 (4%)
Query: 77 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYITPVNSLEKH 135
+A Y+F + + L KG+ L ++ ++ W + ++K G +G +P+NY+ ++
Sbjct: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAG 74
Query: 136 S------WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 189
+ W+HG ++R AE LL G FLVRES + PG ++ + +G+V HYRI
Sbjct: 75 TKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYH 134
Query: 190 ADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDK-WEME 248
A K+ + E F L +LV H+++ ADGL T L PK + TV + W +
Sbjct: 135 AS-KLSIDEEVYFENLMQLVEHYTSDADGLCTRLI--KPKVMEGTVAAQDEFYRSGWALN 191
Query: 249 RTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNL 308
++ + +G G++G+V +G ++ VAVK +K D + FL EA+VM +++H NL
Sbjct: 192 MKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDAT-AQAFLAEASVMTQLRHSNL 248
Query: 309 VQLLGVCTLEPP-FYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK 367
VQLLGV E YIVTEYM G+L+DYLR R + LL + + AMEYLE
Sbjct: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308
Query: 368 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS 427
NF+HRDLAARN LV E++V KV+DFGL++ + T K P+KWTAPE+L FS
Sbjct: 309 NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEALREKKFS 364
Query: 428 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK 487
KSDVW+FG+LLWEI ++G PYP I L V +EKGY+M+ P+GCPP VYE+M+ CW
Sbjct: 365 TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWH 424
Query: 488 WSPADRPSFAETHQAFE 504
A RPSF + + E
Sbjct: 425 LDAAMRPSFLQLREQLE 441
>gi|4758078 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 316 bits (810), Expect = 7e-86
Identities = 178/437 (40%), Positives = 257/437 (58%), Gaps = 19/437 (4%)
Query: 77 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYITPVNSLEKH 135
+A Y+F + + L KG+ L ++ ++ W + ++K G +G +P+NY+ ++
Sbjct: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAG 74
Query: 136 S------WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 189
+ W+HG ++R AE LL G FLVRES + PG ++ + +G+V HYRI
Sbjct: 75 TKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYH 134
Query: 190 ADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDK-WEME 248
A K+ + E F L +LV H+++ ADGL T L PK + TV + W +
Sbjct: 135 AS-KLSIDEEVYFENLMQLVEHYTSDADGLCTRLI--KPKVMEGTVAAQDEFYRSGWALN 191
Query: 249 RTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNL 308
++ + +G G++G+V +G ++ VAVK +K D + FL EA+VM +++H NL
Sbjct: 192 MKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDAT-AQAFLAEASVMTQLRHSNL 248
Query: 309 VQLLGVCTLEPP-FYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK 367
VQLLGV E YIVTEYM G+L+DYLR R + LL + + AMEYLE
Sbjct: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308
Query: 368 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS 427
NF+HRDLAARN LV E++V KV+DFGL++ + T K P+KWTAPE+L FS
Sbjct: 309 NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEALREKKFS 364
Query: 428 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK 487
KSDVW+FG+LLWEI ++G PYP I L V +EKGY+M+ P+GCPP VYE+M+ CW
Sbjct: 365 TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWH 424
Query: 488 WSPADRPSFAETHQAFE 504
A RPSF + + E
Sbjct: 425 LDAAMRPSFLQLREQLE 441
>gi|18250298 src-related kinase lacking C-terminal regulatory
tyrosine and N-terminal myristylation sites [Homo
sapiens]
Length = 488
Score = 305 bits (781), Expect = 2e-82
Identities = 173/432 (40%), Positives = 247/432 (57%), Gaps = 17/432 (3%)
Query: 73 PNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ---GWVPSNYITPV 129
P LF+ALYDF A LS+ +G++L L + G + R +GQ G VP ++
Sbjct: 53 PQLFLALYDFTARCGGELSVRRGDRLCAL--EEGGGYIFARRLSGQPSAGLVPITHVAKA 110
Query: 130 N--SLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYEGRVYHYR 185
+ +L WY VSR+ A+ LL S N G+FL+R SESS G S+S+R + +V HYR
Sbjct: 111 SPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYR 170
Query: 186 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKW 245
++ ADG +Y+ F L EL+ ++ + L +P + +P D W
Sbjct: 171 VSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLL-------QPCMPQKAPRQDVW 223
Query: 246 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 305
E ++ + KLG G +GEV+ G+W SL VA+K +K M++ + KE +K ++H
Sbjct: 224 ERPHSEFALGRKLGEGYFGEVWEGLWLG-SLPVAIKVIKSANMKLTDLAKEIQTLKGLRH 282
Query: 306 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 365
L++L VC+ P YIVTE M GNL +L + LL A Q++ M YLE
Sbjct: 283 ERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLE 342
Query: 366 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 425
++ +HRDLAARN LV + KVADFGL+RL+ D Y+ + +K P+KWTAPE+ Y
Sbjct: 343 EQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRV 402
Query: 426 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 485
FS KSDVW+FGVLL E+ TYG PY G+ + + +GYR+ +P CP +VY LM C
Sbjct: 403 FSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLEC 462
Query: 486 WKWSPADRPSFA 497
W+ SP +RPSFA
Sbjct: 463 WRSSPEERPSFA 474
>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
Length = 620
Score = 305 bits (780), Expect = 2e-82
Identities = 174/471 (36%), Positives = 271/471 (57%), Gaps = 24/471 (5%)
Query: 45 GC---DVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVL 101
GC D A + + + ++N E + + +ALYD+ + L++ + E+ +L
Sbjct: 142 GCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALYDYQTNDPQELALRRNEEYCLL 201
Query: 102 GYNQNGEWSEVRSKNG-QGWVPSNYITPV--NSLEKHSWYHGPVSRSAAE-YLLSSLING 157
++ W V+ +NG +G+VPS+Y+ N+LE + WY+ +SR AE LL + G
Sbjct: 202 DSSEI-HWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKEG 260
Query: 158 SFLVRESESSPGQLSISLRYEGRVY-------HYRINTTADG--KVYVTAESRFSTLAEL 208
+F+VR+S ++ G ++S+ + V HY I T D + YV + F ++ L
Sbjct: 261 AFMVRDSRTA-GTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLL 319
Query: 209 VHHHSTVADGLVTTLHYPA--PKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEV 266
+++H GLVT L YP + P G+ + KW ++ +++T ++G GQ+G V
Sbjct: 320 INYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLR--YGKWVIDPSELTFVQEIGSGQFGLV 377
Query: 267 YVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTE 326
++G W VA+KT++E M E+F++EA VM ++ HP LVQL GVC + P +V E
Sbjct: 378 HLGYWLNKD-KVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFE 436
Query: 327 YMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHV 386
+M +G L DYLR R A LL M + M YLE+ IHRDLAARNCLVGEN V
Sbjct: 437 FMEHGCLSDYLRT-QRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQV 495
Query: 387 VKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYG 446
+KV+DFG++R + D YT+ G KFP+KW +PE +++ +S KSDVW+FGVL+WE+ + G
Sbjct: 496 IKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEG 555
Query: 447 MSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFA 497
PY S+V + + G+R+ +P VY++M CWK P DRP+F+
Sbjct: 556 KIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFS 606
>gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]
Length = 482
Score = 295 bits (754), Expect = 2e-79
Identities = 178/450 (39%), Positives = 246/450 (54%), Gaps = 57/450 (12%)
Query: 75 LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSL 132
LFVALYD+ A ++ LS KGEK ++L ++ G+W E RS G++PSNY+ PV+S+
Sbjct: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSE-GDWWEARSLTTGETGYIPSNYVAPVDSI 144
Query: 133 EKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYEGRVYHYRINTTA 190
+ WY G + R AE L S N G+FL+RESE++ G Y I
Sbjct: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKG-----------AYSLSIRDWD 193
Query: 191 DGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERT 250
D K D + HY K + Y I + + E
Sbjct: 194 DMK----------------------GDHVK---HYKIRKLDNGGYY----ITTRAQFETL 224
Query: 251 DITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ 310
++H Y G W + VA+KTLK TM E FL+EA +MK++KH LVQ
Sbjct: 225 QQLVQH----------YSGTWNG-NTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQ 273
Query: 311 LLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFI 370
L V + E P YIVTEYM G+LLD+L++ + L+ MA Q+++ M Y+E+ N+I
Sbjct: 274 LYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYI 332
Query: 371 HRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKS 430
HRDL + N LVG + K+ADFGL+RL+ + YTA GAKFPIKWTAPE+ Y F+IKS
Sbjct: 333 HRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 392
Query: 431 DVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSP 490
DVW+FG+LL E+ T G PYPG++ +V + +E+GYRM P+ CP ++ELM CWK P
Sbjct: 393 DVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDP 452
Query: 491 ADRPSFAETHQAFETMFHDSSISEEVAEEL 520
+RP+F E F + + E L
Sbjct: 453 EERPTFEYLQSFLEDYFTATEPQYQPGENL 482
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.130 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,159,703
Number of Sequences: 37866
Number of extensions: 2537631
Number of successful extensions: 16114
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 724
Number of HSP's successfully gapped in prelim test: 592
Number of HSP's that attempted gapping in prelim test: 11714
Number of HSP's gapped (non-prelim): 3004
length of query: 1146
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1033
effective length of database: 13,968,660
effective search space: 14429625780
effective search space used: 14429625780
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.