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Search of human proteins with 153218662
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|153218662 cytochrome P450, family 4, subfamily B,
polypeptide 1 isoform a [Homo sapiens]
(512 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide... 1065 0.0
gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide... 1058 0.0
gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide... 527 e-150
gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide ... 494 e-139
gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide ... 477 e-135
gi|30023836 cytochrome P450 4Z1 [Homo sapiens] 455 e-128
gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide ... 415 e-116
gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11... 412 e-115
gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11... 412 e-115
gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide... 405 e-113
gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8... 405 e-113
gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide... 398 e-111
gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide... 395 e-110
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide... 247 2e-65
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ... 149 8e-36
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7... 147 2e-35
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ... 143 4e-34
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5... 140 3e-33
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ... 140 4e-33
gi|5729796 cytochrome P450, family 46 [Homo sapiens] 124 2e-28
gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [H... 110 2e-24
gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [H... 110 2e-24
gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide ... 110 4e-24
gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide ... 100 5e-21
gi|239757171 PREDICTED: similar to cytochrome P450, family 4, su... 99 7e-21
gi|239751683 PREDICTED: similar to cytochrome P450, family 4, su... 99 7e-21
gi|239746187 PREDICTED: similar to cytochrome P450, family 4, su... 99 7e-21
gi|225903399 cytochrome P450, family 51, subfamily A, polypeptid... 99 1e-20
gi|4503243 cytochrome P450, family 51, subfamily A, polypeptide ... 99 1e-20
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ... 99 1e-20
>gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide 1
isoform a [Homo sapiens]
Length = 512
Score = 1065 bits (2753), Expect = 0.0
Identities = 512/512 (100%), Positives = 512/512 (100%)
Query: 1 MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALE 60
MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALE
Sbjct: 1 MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALE 60
Query: 61 IQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQ 120
IQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQ
Sbjct: 61 IQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQ 120
Query: 121 WIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI 180
WIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI
Sbjct: 121 WIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI 180
Query: 181 FCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWL 240
FCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWL
Sbjct: 181 FCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWL 240
Query: 241 TPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK 300
TPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK
Sbjct: 241 TPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK 300
Query: 301 LSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDD 360
LSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDD
Sbjct: 301 LSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDD 360
Query: 361 LGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVW 420
LGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVW
Sbjct: 361 LGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVW 420
Query: 421 PDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLD 480
PDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLD
Sbjct: 421 PDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLD 480
Query: 481 PSRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK 512
PSRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK
Sbjct: 481 PSRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK 512
>gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide 1
isoform b [Homo sapiens]
Length = 511
Score = 1058 bits (2737), Expect = 0.0
Identities = 511/512 (99%), Positives = 511/512 (99%), Gaps = 1/512 (0%)
Query: 1 MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALE 60
MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALE
Sbjct: 1 MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALE 60
Query: 61 IQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQ 120
IQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQ
Sbjct: 61 IQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQ 120
Query: 121 WIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI 180
WIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI
Sbjct: 121 WIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI 180
Query: 181 FCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWL 240
FCDVGHMALNTLMKCTFGRGDTGLGH RDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWL
Sbjct: 181 FCDVGHMALNTLMKCTFGRGDTGLGH-RDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWL 239
Query: 241 TPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK 300
TPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK
Sbjct: 240 TPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK 299
Query: 301 LSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDD 360
LSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDD
Sbjct: 300 LSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDD 359
Query: 361 LGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVW 420
LGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVW
Sbjct: 360 LGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVW 419
Query: 421 PDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLD 480
PDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLD
Sbjct: 420 PDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLD 479
Query: 481 PSRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK 512
PSRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK
Sbjct: 480 PSRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK 511
>gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide 11
[Homo sapiens]
Length = 519
Score = 527 bits (1358), Expect = e-150
Identities = 266/504 (52%), Positives = 334/504 (66%), Gaps = 2/504 (0%)
Query: 3 PSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQ 62
PS L S + AS LIL+L +K + L L RQ L KA+ +FP PP+HWLFGH E+Q
Sbjct: 8 PSRLLGDVSGILQAASLLILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLFGHIQELQ 67
Query: 63 ETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQWI 122
+ L ++ W FP A P W + +Y+PDY K + R DPK+ Y F WI
Sbjct: 68 QDQELQRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGSYRFLAPWI 127
Query: 123 GRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFC 182
G GLL+L G W QHR++LTP FHYD+LKPYV + +S R+MLDKWEE + ++F
Sbjct: 128 GYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQ 187
Query: 183 DVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTP 242
V M L+T+MKC F + SY A+SDL L+ R+ + + ND IY LT
Sbjct: 188 HVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTS 247
Query: 243 HGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLS 302
GR RACQ+AH HTDQVI+ RKA LQ E +KI+ +RHLDFLDILL A+ E+ LS
Sbjct: 248 AGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILS 307
Query: 303 DADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLG 362
D DLRAEVDTFMFEGHDTT SGISW LY +A +P+HQ RCREE+ +LGD W+ L
Sbjct: 308 DKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWNHLD 367
Query: 363 KMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPD 422
+M Y TMCIKE+ RLYPPVP + R+LS PVTF DGRSLP G ++ + IY LH N VWP+
Sbjct: 368 QMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPN 427
Query: 423 PEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPS 482
PEVFD RF+ S +H AF+PFS G RNCIG+QFAM+E+KV TA+ LLRFE DP+
Sbjct: 428 PEVFDPFRFAP--GSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLPDPT 485
Query: 483 RLPIKMPQLVLRSKNGFHLHLKPL 506
R+PI + +LVL+SKNG HL L+ L
Sbjct: 486 RIPIPIARLVLKSKNGIHLRLRRL 509
>gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide 22
[Homo sapiens]
Length = 519
Score = 494 bits (1271), Expect = e-139
Identities = 253/487 (51%), Positives = 317/487 (65%), Gaps = 2/487 (0%)
Query: 20 LILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQETGSLDKVVSWAHQFPY 79
LIL+L +K L L RQ L KA+ +FP PP+HWLFGH E Q L ++ FP
Sbjct: 25 LILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWLFGHIQEFQHDQELQRIQERVKTFPS 84
Query: 80 AHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGRGLLVLEGPKWLQHRK 139
A P W + +Y+PDY K + R DPK+ Y F IG GLL+L G W QHR+
Sbjct: 85 ACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGSYKFLAPRIGYGLLLLNGQTWFQHRR 144
Query: 140 LLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGR 199
+LTP FH D+LKPYV + +S R+MLDKWEE + ++F V M L+T+MK F
Sbjct: 145 MLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKSAFSH 204
Query: 200 GDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTD 259
+ SY A+SDL L+ + + + ND IY LT GR RACQ+AH HTD
Sbjct: 205 QGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQHTD 264
Query: 260 QVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHD 319
QVI+ RKA LQ E +KI+ +RHLDFLDILL A+ E+ LSD DLRAEVDTFMFEGHD
Sbjct: 265 QVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHD 324
Query: 320 TTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFRLYP 379
TT SGISW LY +A +P+HQ RCREE+ +LGD W+ L +M Y TMCIKE+ RLYP
Sbjct: 325 TTASGISWILYALATHPKHQERCREEIHGLLGDGASITWNHLDQMPYTTMCIKEALRLYP 384
Query: 380 PVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKR 439
PVP + R+LS PVTF DGRSLP G ++ + IY LH N VWP+ EVFD RF+ S +
Sbjct: 385 PVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAP--GSAQ 442
Query: 440 HPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGF 499
H AF+PFS G RNCIG+QFAM+++KV A+ LLRFE DP+R+PI M +LVL+SKNG
Sbjct: 443 HSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLPDPTRIPIPMARLVLKSKNGI 502
Query: 500 HLHLKPL 506
HL L+ L
Sbjct: 503 HLRLRRL 509
>gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide 1
[Homo sapiens]
Length = 509
Score = 477 bits (1228), Expect = e-135
Identities = 234/487 (48%), Positives = 320/487 (65%), Gaps = 4/487 (0%)
Query: 22 LVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQETGSLDKVVSWAHQFPYAH 81
L LG L+ I L LRRQ L + + FP PPTHW GH IQ+ +++K+ ++P A
Sbjct: 22 LALGLLQAIKLYLRRQRLLRDLRPFPAPPTHWFLGHQKFIQDD-NMEKLEEIIEKYPRAF 80
Query: 82 PLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGRGLLVLEGPKWLQHRKLL 141
P W G F F IY+PDYAK + SR DPK+ + F +G+GL L+GPKW QHR+LL
Sbjct: 81 PFWIGPFQAFFCIYDPDYAKTLLSRTDPKSQYLQKFSPPLLGKGLAALDGPKWFQHRRLL 140
Query: 142 TPGFHYDVLKPYVAVFTESTRIMLDKWEEK-AREGKSFDIFCDVGHMALNTLMKCTFGRG 200
TPGFH+++LK Y+ V S ++MLDKWE+ + + S +++ + M+L+ +MKC F +
Sbjct: 141 TPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKE 200
Query: 201 DTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQ 260
+S Y A+ +L+ ++ RL S YH+D I+ L+P G RF + +V + +TD
Sbjct: 201 TNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDT 260
Query: 261 VIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDT 320
+I+ERK +LQ + R++ DFLDI+L A+DE SD D+ +EV TF+ GHDT
Sbjct: 261 IIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDT 320
Query: 321 TTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFRLYPP 380
+ ISW LYC+AL PEHQ RCREEVR ILGD WD LG+M+Y TMCIKE+ RL P
Sbjct: 321 LAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQLGEMSYTTMCIKETCRLIPA 380
Query: 381 VPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRH 440
VP + R LSKP+TF DG +LPAG + + I+ LH N AVW +P+VFD LRFS EN+ +RH
Sbjct: 381 VPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRH 440
Query: 441 PFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMP-QLVLRSKNGF 499
P+A++PFSAG RNCIGQ+FAM E+KV A+ LL F + DP+R P+ P +L+ KNG
Sbjct: 441 PYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTR-PLTFPNHFILKPKNGM 499
Query: 500 HLHLKPL 506
+LHLK L
Sbjct: 500 YLHLKKL 506
>gi|30023836 cytochrome P450 4Z1 [Homo sapiens]
Length = 505
Score = 455 bits (1171), Expect = e-128
Identities = 229/505 (45%), Positives = 323/505 (63%), Gaps = 4/505 (0%)
Query: 1 MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALE 60
M PS+L + L L + L ++I L RR+ + +A+ FP PP HW +GH E
Sbjct: 1 MEPSWLQELMAHPFLLLILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPAHWFYGHK-E 59
Query: 61 IQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQ 120
+ ++P A PLW G F F ++++PDYAK + R DPK+ +
Sbjct: 60 FYPVKEFEVYHKLMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQDPKSAVSHKILES 119
Query: 121 WIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI 180
W+GRGL+ L+G KW +HR+++ PGF+ +LK ++ + +ES R+ML+KWEE + ++
Sbjct: 120 WVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLEL 179
Query: 181 FCDVGHMALNTLMKCTFG-RGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYW 239
F V M L+++MKC F +G L + DS Y AV +L+ + QR+ +F +HND ++
Sbjct: 180 FQHVSLMTLDSIMKCAFSHQGSIQLDSTLDS-YLKAVFNLSKISNQRMNNFLHHNDLVFK 238
Query: 240 LTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDI 299
+ G+ F + Q H T++VI++RK +L+D K+++ +R DFLDILL A+ E+
Sbjct: 239 FSSQGQIFSKFNQELHQFTEKVIQDRKESLKD-KLKQDTTQKRRWDFLDILLSAKSENTK 297
Query: 300 KLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWD 359
S+ADL+AEV TFMF GHDTT+S ISW LYC+A YPEHQ RCR+E+RE+LGD W+
Sbjct: 298 DFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSITWE 357
Query: 360 DLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAV 419
L +M Y TMCIKE RLY PV + R L KP+TF DGRSLPAG + ++I+ALH N
Sbjct: 358 HLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYF 417
Query: 420 WPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSL 479
W DP+VF+ LRFS EN+ K HP+AF+PFSAG RNCIGQ FA+ E KV A+ LLRF+ +
Sbjct: 418 WEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAP 477
Query: 480 DPSRLPIKMPQLVLRSKNGFHLHLK 504
D SR P + Q+VL+SKNG H+ K
Sbjct: 478 DHSRPPQPVRQVVLKSKNGIHVFAK 502
>gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide 2
[Homo sapiens]
Length = 520
Score = 415 bits (1066), Expect = e-116
Identities = 224/519 (43%), Positives = 315/519 (60%), Gaps = 23/519 (4%)
Query: 8 LSFSSLGLWASG------LILVLGFLKLIHLLLRRQTL---AKAMDKFPGPPT-HWLFGH 57
LS S LGLW L+LV L H+L + + FP PP +W +GH
Sbjct: 4 LSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGH 63
Query: 58 ALEIQETGSLDKVVSW-AHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPD--- 113
+ T +V++ +P +W G L++ PD ++V + AP
Sbjct: 64 QGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKF 123
Query: 114 VYDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAR 173
Y F W+G GLL+ G KW +HR++LTP FH+++LKPY+ +F ES IM KW+ A
Sbjct: 124 FYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLAS 183
Query: 174 EGKS-FDIFCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQY 232
EG + D+F + M L++L KC F + S Y A+ +L+ L+ +R
Sbjct: 184 EGSACLDMFEHISLMTLDSLQKCVFSFDSHC--QEKPSEYIAAILELSALVSKRHHEILL 241
Query: 233 HNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNR---RHLDFLDI 289
H DF+Y+LTP G+RF RAC++ HD TD VI+ER+ L + V +Q + + LDF+D+
Sbjct: 242 HIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDV 301
Query: 290 LLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREI 349
LL ++DED KLSD D+RAE DTFMFEGHDTT SG+SW LY +A +PE+Q RCR+EV+E+
Sbjct: 302 LLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQEL 361
Query: 350 LGDQD--FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLIS 407
L D++ +WDDL + +LTMC+KES RL+PPVP + R +++ + DGR +P G +
Sbjct: 362 LKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICL 421
Query: 408 MHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVV 467
+ ++ H N AVWPDPEV+D RF EN +R P AF+PFSAGPRNCIGQ FAM+EMKVV
Sbjct: 422 ISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVV 481
Query: 468 TAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLKPL 506
A+ LLRF D + P + P+LVLR++ G L ++PL
Sbjct: 482 LALTLLRFRVLPDHTE-PRRKPELVLRAEGGLWLRVEPL 519
>gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11
[Homo sapiens]
Length = 524
Score = 412 bits (1058), Expect = e-115
Identities = 222/523 (42%), Positives = 314/523 (60%), Gaps = 21/523 (4%)
Query: 6 LSLSFSSLGLWASG----LILVLGFLKLIHLLLRRQTL---AKAMDKFPGPPT-HWLFGH 57
LSLS+ LG A+ L+LV G L +L T + + FP PP +W +GH
Sbjct: 4 LSLSWLGLGPVAASPWLLLLLVGGSWLLARVLAWTYTFYDNCRRLQCFPQPPKQNWFWGH 63
Query: 58 ALEIQETGS-LDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPD--- 113
+ T + + +P LW G L + PD + + S AP
Sbjct: 64 QGLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMI 123
Query: 114 VYDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAR 173
Y F W+G GLL+ G KW +HR++LTP FH+++LKPY+ +F +S IM DKW+ A
Sbjct: 124 FYGFLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLAS 183
Query: 174 EGKS-FDIFCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQY 232
EG + D+F + M L++L KC F + S Y A+ +L+ +++R
Sbjct: 184 EGSARLDMFEHISLMTLDSLQKCVFSFESNC--QEKPSEYIAAILELSAFVEKRNQQILL 241
Query: 233 HNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNR---RHLDFLDI 289
H DF+Y+LTP G+RF RAC + HD TD VI+ER+ L + + ++N+ + LDF+D+
Sbjct: 242 HTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFIDV 301
Query: 290 LLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREI 349
LL ++DED +LSD D+RAE DTFMFEGHDTT SG+SW LY +A +PE+Q +CR+EV+E+
Sbjct: 302 LLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQEL 361
Query: 350 LGDQD--FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLIS 407
L D++ +WDDL ++ +LTMCIKES RL+PPVP + R ++ DGR +P G +
Sbjct: 362 LKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCL 421
Query: 408 MHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVV 467
++I +H N VWPDPEV+D RF EN +R P AF+PFSAGPRNCIGQ FAM+EMKVV
Sbjct: 422 INIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVV 481
Query: 468 TAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLKPLGPGS 510
A+ LL F L P + P+L+LR++ G L ++PLG S
Sbjct: 482 LALTLLHFRI-LPTHTEPRRKPELILRAEGGLWLRVEPLGANS 523
>gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11
[Homo sapiens]
Length = 524
Score = 412 bits (1058), Expect = e-115
Identities = 222/523 (42%), Positives = 314/523 (60%), Gaps = 21/523 (4%)
Query: 6 LSLSFSSLGLWASG----LILVLGFLKLIHLLLRRQTL---AKAMDKFPGPPT-HWLFGH 57
LSLS+ LG A+ L+LV G L +L T + + FP PP +W +GH
Sbjct: 4 LSLSWLGLGPVAASPWLLLLLVGGSWLLARVLAWTYTFYDNCRRLQCFPQPPKQNWFWGH 63
Query: 58 ALEIQETGS-LDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPD--- 113
+ T + + +P LW G L + PD + + S AP
Sbjct: 64 QGLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMI 123
Query: 114 VYDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAR 173
Y F W+G GLL+ G KW +HR++LTP FH+++LKPY+ +F +S IM DKW+ A
Sbjct: 124 FYGFLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLAS 183
Query: 174 EGKS-FDIFCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQY 232
EG + D+F + M L++L KC F + S Y A+ +L+ +++R
Sbjct: 184 EGSARLDMFEHISLMTLDSLQKCVFSFESNC--QEKPSEYIAAILELSAFVEKRNQQILL 241
Query: 233 HNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNR---RHLDFLDI 289
H DF+Y+LTP G+RF RAC + HD TD VI+ER+ L + + ++N+ + LDF+D+
Sbjct: 242 HTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFIDV 301
Query: 290 LLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREI 349
LL ++DED +LSD D+RAE DTFMFEGHDTT SG+SW LY +A +PE+Q +CR+EV+E+
Sbjct: 302 LLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQEL 361
Query: 350 LGDQD--FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLIS 407
L D++ +WDDL ++ +LTMCIKES RL+PPVP + R ++ DGR +P G +
Sbjct: 362 LKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCL 421
Query: 408 MHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVV 467
++I +H N VWPDPEV+D RF EN +R P AF+PFSAGPRNCIGQ FAM+EMKVV
Sbjct: 422 INIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVV 481
Query: 468 TAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLKPLGPGS 510
A+ LL F L P + P+L+LR++ G L ++PLG S
Sbjct: 482 LALTLLHFRI-LPTHTEPRRKPELILRAEGGLWLRVEPLGANS 523
>gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide 3
[Homo sapiens]
Length = 520
Score = 405 bits (1042), Expect = e-113
Identities = 228/520 (43%), Positives = 310/520 (59%), Gaps = 25/520 (4%)
Query: 8 LSFSSLGLWASG------LILVLGFLKLIHLLLRRQTLAKAMDK---FPGPPT-HWLFGH 57
LS SSLGLW L+LV L +L T + FP PP +W GH
Sbjct: 4 LSLSSLGLWPMAASPWLLLLLVGASWLLARILAWTYTFYDNCCRLRCFPQPPKRNWFLGH 63
Query: 58 A--LEIQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGD---PKAP 112
+ E G L S A F W G + + I+ P Y K V PK
Sbjct: 64 LGLIHSSEEGLL-YTQSLACTFGDMCCWWVGPWHAIVRIFHPTYIKPVLFAPAAIVPKDK 122
Query: 113 DVYDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKA 172
Y F W+G GLL+ G KW +HR++LTP FH+++LKPY+ +F ES IM KW+ A
Sbjct: 123 VFYSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLA 182
Query: 173 REGKS-FDIFCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQ 231
EG + D+F + M L++L KC F + S Y A+ +L+ L+ +R
Sbjct: 183 SEGSARLDMFEHISLMTLDSLQKCVFSFDSHC--QEKPSEYIAAILELSALVTKRHQQIL 240
Query: 232 YHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNR---RHLDFLD 288
+ DF+Y+LTP G+RF RAC++ HD TD VI+ER+ L + V +Q + + LDF+D
Sbjct: 241 LYIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFID 300
Query: 289 ILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVRE 348
+LL ++DED KLSD D+RAE DTFMFEGHDTT SG+SW LY +A +PE+Q RCR+EV+E
Sbjct: 301 VLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQE 360
Query: 349 ILGDQD--FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLI 406
+L D++ +WDDL ++ +LTMCIKES RL+PPVP V R ++ + DGR +P G +
Sbjct: 361 LLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIIC 420
Query: 407 SMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKV 466
+ ++ H N AVWPDPEV+D RF +N +R P AF+PFSAGPRNCIGQ FAM+EMKV
Sbjct: 421 LISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKV 480
Query: 467 VTAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLKPL 506
V + LLRF D + P + P+LVLR++ G L ++PL
Sbjct: 481 VLGLTLLRFRVLPDHTE-PRRKPELVLRAEGGLWLRVEPL 519
>gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8
[Homo sapiens]
Length = 520
Score = 405 bits (1042), Expect = e-113
Identities = 222/522 (42%), Positives = 319/522 (61%), Gaps = 21/522 (4%)
Query: 4 SFLSLSFSSLGLWASG---LILVLGFLKLIHLLLRRQTL----AKAMDKFPGP-PTHWLF 55
S LSLS+ L A+ L+LV+G L+ +L + + FP P +W
Sbjct: 2 SLLSLSWLGLRPVAASPWLLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWFL 61
Query: 56 GHALEIQETGS-LDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDP---KA 111
GH + T L + +P W G +N+ PD ++V + D K
Sbjct: 62 GHLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDKD 121
Query: 112 PDVYDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEK 171
Y W+G GLL+ G KW HR+LLTP FH+++LKPY+ +F++S IM KW+
Sbjct: 122 IVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQRL 181
Query: 172 AREGKS-FDIFCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSF 230
A EG + D+F + M L++L KC F + S Y A+ +L+ L+ +R F
Sbjct: 182 AMEGSTCLDVFEHISLMTLDSLQKCIFSFDSNC--QEKPSEYITAIMELSALVVKRNNQF 239
Query: 231 QYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNR---RHLDFL 287
+ DF+Y+LTP GRRF RAC++ HD TD VI+ER+ L + V +Q + + LDF+
Sbjct: 240 FRYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFI 299
Query: 288 DILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVR 347
D+LL + D++ +LSD D+RAE DTFMF GHDTT SG+SW LY +A +PE+Q RCR+EV+
Sbjct: 300 DVLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQ 359
Query: 348 EILGDQD--FFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSL 405
E+L D++ +WDDL ++ +LTMC+KES RL+PP+P R ++ V D R +P G++
Sbjct: 360 ELLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNV 419
Query: 406 ISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMK 465
+++I+A+H N +VWPDPEV+D RF ENA KR P AF+PFSAGPRNCIGQ+FAM+EMK
Sbjct: 420 CNINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMK 479
Query: 466 VVTAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLKPLG 507
VV A+ LLRF L R P + P++VLR+++G L ++PLG
Sbjct: 480 VVLALTLLRFRI-LPDHREPRRTPEIVLRAEDGLWLRVEPLG 520
>gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide 22
[Homo sapiens]
Length = 531
Score = 398 bits (1022), Expect = e-111
Identities = 212/520 (40%), Positives = 306/520 (58%), Gaps = 19/520 (3%)
Query: 6 LSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKA-------MDKFPGPPT-HWLFGH 57
L L ++ ++A +L+ L LLLR L ++ + FP PP +WL GH
Sbjct: 12 LGLEKTAFRIYAVSTLLLFLLFFLFRLLLRFLRLCRSFYITCRRLRCFPQPPRRNWLLGH 71
Query: 58 -ALEIQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPD--- 113
+ + L + +W G + L + PDY K + AP
Sbjct: 72 LGMYLPNEAGLQDEKKVLDNMHHVLLVWMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDL 131
Query: 114 VYDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAR 173
Y F W+G GLL+ +G KW +HR+LLTP FH+D+LKPY+ +F +S IM KW A
Sbjct: 132 FYGFLKPWLGDGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAE 191
Query: 174 -EGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQY 232
S D+F + M L++L KC F + S Y A+ +L+ L +R +
Sbjct: 192 GSAVSLDMFEHISLMTLDSLQKCVFSYNSNC--QEKMSDYISAIIELSALSVRRQYRLHH 249
Query: 233 HNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRK--KIQNRRHLDFLDIL 290
+ DFIY+ + GRRF +AC + H T +VI+ER+ AL+ + K + + LDF+D+L
Sbjct: 250 YLDFIYYRSADGRRFRQACDMVHHFTTEVIQERRRALRQQGAEAWLKAKQGKTLDFIDVL 309
Query: 291 LGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREIL 350
L ARDED +LSD D+RAE DTFMFEGHDTT+SGISW L+ +A YPE+Q +CREE++E++
Sbjct: 310 LLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVM 369
Query: 351 GDQDF--FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISM 408
++ +WDDL ++ + TMCIKES R YPPV V RQ ++ + DGR +P G + +
Sbjct: 370 KGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLV 429
Query: 409 HIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVT 468
IY H N VWPD +V++ RF +N +R P A++PFSAGPRNCIGQ FAM+E++VV
Sbjct: 430 SIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVV 489
Query: 469 AMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLKPLGP 508
A+ LLRF S+D +R + P+L+LR++NG L ++PL P
Sbjct: 490 ALTLLRFRLSVDRTRKVRRKPELILRTENGLWLKVEPLPP 529
>gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide 12
[Homo sapiens]
Length = 524
Score = 395 bits (1016), Expect = e-110
Identities = 211/504 (41%), Positives = 306/504 (60%), Gaps = 17/504 (3%)
Query: 20 LILVLGFLKLIHLLLRRQTL---AKAMDKFPGPPT-HWLFGHALEIQETGS-LDKVVSWA 74
L+LV+G L +L + + FP PP +W +GH I T L +
Sbjct: 22 LLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWFWGHLGLITPTEEGLKDSTQMS 81
Query: 75 HQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAP--DVYDFFLQ-WIGRGLLVLEG 131
+ +W G I F+ + PD +++ + AP +++ FL+ W+G G+L+ G
Sbjct: 82 ATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLSGG 141
Query: 132 PKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKS-FDIFCDVGHMALN 190
KW +HR++LTP FH+++LK Y+ +F +S IMLDKW+ A EG S D+F + M L+
Sbjct: 142 DKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLD 201
Query: 191 TLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRA 250
+L KC F R S Y + +L+ L+++R H DF+Y+L+ GRRF RA
Sbjct: 202 SLQKCIFSFDSHC--QERPSEYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRA 259
Query: 251 CQVAHDHTDQVIRERKAALQDEKVRKKIQNR---RHLDFLDILLGARDEDDIKLSDADLR 307
C++ HD TD VIRER+ L + + +++ + LDF+D+LL ++DED LSD D+R
Sbjct: 260 CRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDVLLLSKDEDGKALSDEDIR 319
Query: 308 AEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQD--FFQWDDLGKMT 365
AE DTFMF GHDTT SG+SW LY +A +PE+Q RCR+EV+E+L D+D +WDDL ++
Sbjct: 320 AEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLP 379
Query: 366 YLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEV 425
+LTMC+KES RL+PP P + R ++ + DGR +P G + I +H N VWPDPEV
Sbjct: 380 FLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEV 439
Query: 426 FDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLP 485
+D RF EN+ R P AF+PFSAGPRNCIGQ FAM+EMKVV A+ LL F F D + P
Sbjct: 440 YDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTE-P 498
Query: 486 IKMPQLVLRSKNGFHLHLKPLGPG 509
+ +L++R++ G L ++PL G
Sbjct: 499 RRKLELIMRAEGGLWLRVEPLNVG 522
>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
[Homo sapiens]
Length = 525
Score = 247 bits (631), Expect = 2e-65
Identities = 167/523 (31%), Positives = 265/523 (50%), Gaps = 24/523 (4%)
Query: 1 MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRR-QTLAKAMDKFPGPPT----HWLF 55
M +L L + L LW + L L L+ LL+R + A+ + PT + L
Sbjct: 1 MAGLWLGLVWQKLLLWGAASALSLAGASLVLSLLQRVASYARKWQQMRPIPTVARAYPLV 60
Query: 56 GHALEIQETGS--LDKVVSWAHQFPYAH--PLWFGQFIGFLNIYEPDYAKAVYSRGDP-K 110
GHAL ++ G +++ + ++ + LW G + + +Y + + + +
Sbjct: 61 GHALLMKPDGREFFQQIIEYTEEYRHMPLLKLWVGP-VPMVALYNAENVEVILTSSKQID 119
Query: 111 APDVYDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEE 170
+Y F W+G GLL G KW RK+LTP FH+ +L+ ++ + E I++ K E+
Sbjct: 120 KSSMYKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEK 179
Query: 171 KAREGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSF 230
+ ++F+ F + AL+ + + G+ + G + DS Y AV ++ ++ +R+
Sbjct: 180 HINQ-EAFNCFFYITLCALDIICETAMGK-NIGAQSNDDSEYVRAVYRMSEMIFRRIKMP 237
Query: 231 QYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQ-------DEKVRKKIQNRRH 283
D Y + G ++ Q+ H T+ VI ER + D + +N+R
Sbjct: 238 WLWLDLWYLMFKEGWEHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRR 297
Query: 284 LDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCR 343
FLD+LL D++ +LS D+R EVDTFMFEGHDTT + I+W LY + PE Q +
Sbjct: 298 A-FLDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVD 356
Query: 344 EEVREILGDQDF-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPA 402
E+ ++ G D +DL K+ YL IKE+ RL+P VP R +S+ R L
Sbjct: 357 HELDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKG 416
Query: 403 GSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMS 462
+ + YALHR+ +P+PE F RF ENA RHP+A++PFSAGPRNCIGQ+FA+
Sbjct: 417 TEAVIIP-YALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVM 475
Query: 463 EMKVVTAMCLLRFEFSLDPSRLPIKMP-QLVLRSKNGFHLHLK 504
E K + + L F + R + + QL+LR NG + LK
Sbjct: 476 EEKTILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLK 518
>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
[Homo sapiens]
Length = 503
Score = 149 bits (375), Expect = 8e-36
Identities = 97/371 (26%), Positives = 186/371 (50%), Gaps = 23/371 (6%)
Query: 128 VLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHM 187
+ E +W + R LL+P F LK V + + +++ +A GK + G
Sbjct: 120 IAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAY 179
Query: 188 ALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHG--- 244
+++ + +FG L + +D + ++L+ F + + F +T
Sbjct: 180 SMDVITSTSFGVNIDSLNNPQDPF---------VENTKKLLRFDFLDPFFLSITVFPFLI 230
Query: 245 --RRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK-- 300
L C + T+ + RK+ + ++ R + + +DFL +++ +++ + +
Sbjct: 231 PILEVLNICVFPREVTNFL---RKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESH 287
Query: 301 --LSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQW 358
LSD +L A+ F+F G++TT+S +S+ +Y +A +P+ Q + +EE+ +L ++ +
Sbjct: 288 KALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTY 347
Query: 359 DDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSA 418
D + +M YL M + E+ RL+P ++ R K V ++G +P G ++ + YALHR+
Sbjct: 348 DTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVE-INGMFIPKGVVVMIPSYALHRDPK 406
Query: 419 VWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFS 478
W +PE F RFS +N P+ + PF +GPRNCIG +FA+ MK+ L F F
Sbjct: 407 YWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFK 466
Query: 479 -LDPSRLPIKM 488
+++P+K+
Sbjct: 467 PCKETQIPLKL 477
>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
[Homo sapiens]
Length = 503
Score = 147 bits (372), Expect = 2e-35
Identities = 111/428 (25%), Positives = 198/428 (46%), Gaps = 33/428 (7%)
Query: 92 LNIYEPDYAKAVYSRGDPKAPDVYDFFLQ--------WIGRGLLVLEGPKWLQHRKLLTP 143
L I +PD K V + + Y F ++ + + E +W + R LL+P
Sbjct: 82 LAITDPDMIKTVLVK------ECYSVFTNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSP 135
Query: 144 GFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTG 203
F LK V + + +++ +A GK + G +++ + +FG
Sbjct: 136 TFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDS 195
Query: 204 LGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIR 263
L + +D + LL L F +LTP L A + +
Sbjct: 196 LNNPQDP---FVENTKKLLRFNPLDPFVLSIKVFPFLTP----ILEALNITVFPRKVISF 248
Query: 264 ERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK----LSDADLRAEVDTFMFEGHD 319
K+ Q ++ R K + +DFL +++ +++ D + LSD +L A+ F+F G++
Sbjct: 249 LTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYE 308
Query: 320 TTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFRLYP 379
TT+S +S+ +Y +A +P+ Q + ++E+ +L ++ +D + ++ YL M + E+ RL+P
Sbjct: 309 TTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFP 368
Query: 380 PVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKR 439
++ R K V ++G +P G ++ + Y LH + W +PE F RFS +N
Sbjct: 369 VAMRLERVCKKDVE-INGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNI 427
Query: 440 HPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLRSK-NG 498
P+ + PF +GPRNCIG +FA+ MK+ L F F P K Q+ L+ + G
Sbjct: 428 DPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFK------PCKETQIPLKLRFGG 481
Query: 499 FHLHLKPL 506
L KP+
Sbjct: 482 LLLTEKPI 489
>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 2 [Homo sapiens]
Length = 503
Score = 143 bits (360), Expect = 4e-34
Identities = 107/422 (25%), Positives = 198/422 (46%), Gaps = 45/422 (10%)
Query: 92 LNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGRG--------LLVLEGPKWLQHRKLLTP 143
L I +PD K V + + Y F + G L E +W + R LL+P
Sbjct: 82 LVIMDPDMIKTVLVK------ECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSP 135
Query: 144 GFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTG 203
F K V + ++ +++ ++A KS ++ G ++ + FG
Sbjct: 136 AFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDS 195
Query: 204 LGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIY------WLTPHGRRF---LRACQVA 254
L + +D L ++L+ + + F+ +LTP L V
Sbjct: 196 LNNPQDPF---------LKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVT 246
Query: 255 HDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK----LSDADLRAEV 310
H + + R +++ L+D++ + +DF ++ +++ + K LSD +L A+
Sbjct: 247 HFLKNSIERMKESRLKDKQ-------KHRVDFFQQMIDSQNSKETKSHKALSDLELVAQS 299
Query: 311 DTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMC 370
+F +DTT++ + + +Y +A +P+ Q + +EE+ +L ++ +D L +M YL M
Sbjct: 300 IIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMV 359
Query: 371 IKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLR 430
+ E+ RL+P V +V R K + ++G +P G + + IYALH + W +PE F R
Sbjct: 360 VNETLRLFPVVSRVTRVCKKDIE-INGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPER 418
Query: 431 FSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFS-LDPSRLPIKMP 489
FS +N + ++PF AGPRNCIG +FA++ +K+ L F F +++P+K+
Sbjct: 419 FSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLD 478
Query: 490 QL 491
L
Sbjct: 479 NL 480
>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
[Homo sapiens]
Length = 502
Score = 140 bits (353), Expect = 3e-33
Identities = 100/369 (27%), Positives = 183/369 (49%), Gaps = 24/369 (6%)
Query: 130 EGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMAL 189
E +W + R LL+P F LK + + +++ +A +GK + G ++
Sbjct: 122 EDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSM 181
Query: 190 NTLMKCTFGRGDTGLGHSRD-----SSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHG 244
+ + +FG L + +D + +L L L ++ F + LTP
Sbjct: 182 DVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLS-IILFPF-------LTP-- 231
Query: 245 RRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK---- 300
A V+ D + K+ + +K R + + LDFL +++ +++ + +
Sbjct: 232 --VFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKA 289
Query: 301 LSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDD 360
LSD +L A+ F+F G++TT+S +S+ LY +A +P+ Q + ++E+ +L ++ +D
Sbjct: 290 LSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDA 349
Query: 361 LGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVW 420
+ +M YL M + E+ RL+P ++ R K V ++G +P GS++ + YALH + W
Sbjct: 350 VVQMEYLDMVVNETLRLFPVAIRLERTCKKDVE-INGVFIPKGSMVVIPTYALHHDPKYW 408
Query: 421 PDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFS-L 479
+PE F RFS + S P+ + PF GPRNCIG +FA+ MK+ L F F
Sbjct: 409 TEPEEFRPERFSKKKDS-IDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPC 467
Query: 480 DPSRLPIKM 488
+++P+K+
Sbjct: 468 KETQIPLKL 476
>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 1 [Homo sapiens]
Length = 504
Score = 140 bits (352), Expect = 4e-33
Identities = 107/423 (25%), Positives = 198/423 (46%), Gaps = 46/423 (10%)
Query: 92 LNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGRG--------LLVLEGPKWLQHRKLLTP 143
L I +PD K V + + Y F + G L E +W + R LL+P
Sbjct: 82 LVIMDPDMIKTVLVK------ECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSP 135
Query: 144 GFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTG 203
F K V + ++ +++ ++A KS ++ G ++ + FG
Sbjct: 136 AFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDS 195
Query: 204 LGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIY------WLTPHGRRF---LRACQVA 254
L + +D L ++L+ + + F+ +LTP L V
Sbjct: 196 LNNPQDPF---------LKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVT 246
Query: 255 HDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK----LSDADLRAEV 310
H + + R +++ L+D++ + +DF ++ +++ + K LSD +L A+
Sbjct: 247 HFLKNSIERMKESRLKDKQ-------KHRVDFFQQMIDSQNSKETKSHKALSDLELVAQS 299
Query: 311 DTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMC 370
+F +DTT++ + + +Y +A +P+ Q + +EE+ +L ++ +D L +M YL M
Sbjct: 300 IIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMV 359
Query: 371 IKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVF-DSL 429
+ E+ RL+P V +V R K + ++G +P G + + IYALH + W +PE F
Sbjct: 360 VNETLRLFPVVSRVTRVCKKDIE-INGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPES 418
Query: 430 RFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFS-LDPSRLPIKM 488
RFS +N + ++PF AGPRNCIG +FA++ +K+ L F F +++P+K+
Sbjct: 419 RFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKL 478
Query: 489 PQL 491
L
Sbjct: 479 DNL 481
>gi|5729796 cytochrome P450, family 46 [Homo sapiens]
Length = 500
Score = 124 bits (311), Expect = 2e-28
Identities = 105/381 (27%), Positives = 170/381 (44%), Gaps = 29/381 (7%)
Query: 133 KWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTL 192
+W + R+++ F L + F E +++ E KA + + + A++ L
Sbjct: 133 RWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDIL 192
Query: 193 MKCTFGRGDTGLGHSRDSSYYL-AVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRAC 251
K FG ++S L A L+ ++ L + + P R+ LR
Sbjct: 193 AKAAFGM---------ETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREV 243
Query: 252 Q-----VAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADL 306
+ + D V R R+A + E+V I + L GA+D D L
Sbjct: 244 RESIRFLRQVGRDWVQRRREALKRGEEVPADILTQ----ILKAEEGAQD-------DEGL 292
Query: 307 RAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTY 366
TF GH+T+ + +++ + ++ PE R + EV E++G + + ++DLG++ Y
Sbjct: 293 LDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQY 352
Query: 367 LTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVF 426
L+ +KES RLYPP +R L + T +DG +P + + Y + R + DP F
Sbjct: 353 LSQVLKESLRLYPPAWGTFRLLEEE-TLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTF 411
Query: 427 DSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPI 486
+ RF R F + PFS G R+CIGQQFA E+KVV A L R EF L P +
Sbjct: 412 NPDRFGPGAPKPR--FTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFG 469
Query: 487 KMPQLVLRSKNGFHLHLKPLG 507
Q L+ + L+P G
Sbjct: 470 LQEQATLKPLDPVLCTLRPRG 490
>gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [Homo
sapiens]
Length = 534
Score = 110 bits (276), Expect = 2e-24
Identities = 111/471 (23%), Positives = 210/471 (44%), Gaps = 72/471 (15%)
Query: 86 GQFIG---FLNIYEPDYAKAV----YSRGDPKAPDVYDFFLQWIGRGLLVLEGPKWLQHR 138
G ++G F+ I EPD K V +S + +F + + +L L +W + R
Sbjct: 80 GYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEF--KSVADSVLFLRDKRWEEVR 137
Query: 139 KLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI---FCD-----VGHMALN 190
L F + L V + +++ ++L + A G +FDI +C+ V +A
Sbjct: 138 GALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFG 197
Query: 191 TLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRA 250
T + D + H + + + +L L+SF + + P+ R
Sbjct: 198 TPVDSWQAPEDPFVKHCKRFFEFCIPRPILVL----LLSFPSIMVPLARILPNKNR---- 249
Query: 251 CQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDE-DDIKLSDADLRAE 309
+ +++IR AL+D++ ++ R DFL ++L AR + + D D+ +
Sbjct: 250 -DELNGFFNKLIRN-VIALRDQQAAEE----RRRDFLQMVLDARHSASPMGVQDFDIVRD 303
Query: 310 VDT--------------------------------FMFEGHDTTTSGISWFLYCMALYPE 337
V + F+ G++ T+ +S+ Y +A P+
Sbjct: 304 VFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPD 363
Query: 338 HQHRCREEV---REILGDQDFFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTF 394
Q + EV +E +F ++ + YL M I E+ R+YPP + R+ ++
Sbjct: 364 CQEKLLREVDVFKEKHMAPEFCSLEE--GLPYLDMVIAETLRMYPPAFRFTREAAQDCEV 421
Query: 395 VDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNC 454
+ G+ +PAG+++ M + ALH + WP PE F+ RF+ E + PF ++PF AGPR+C
Sbjct: 422 L-GQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSC 480
Query: 455 IGQQFAMSEMKVVTAMCLLRFEFSLDP-SRLPIKM-PQLVLRSKNGFHLHL 503
+G + + E+K+ L +F F P +++P+++ + L KNG ++ +
Sbjct: 481 LGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKI 531
>gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [Homo
sapiens]
Length = 534
Score = 110 bits (276), Expect = 2e-24
Identities = 111/471 (23%), Positives = 210/471 (44%), Gaps = 72/471 (15%)
Query: 86 GQFIG---FLNIYEPDYAKAV----YSRGDPKAPDVYDFFLQWIGRGLLVLEGPKWLQHR 138
G ++G F+ I EPD K V +S + +F + + +L L +W + R
Sbjct: 80 GYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEF--KSVADSVLFLRDKRWEEVR 137
Query: 139 KLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI---FCD-----VGHMALN 190
L F + L V + +++ ++L + A G +FDI +C+ V +A
Sbjct: 138 GALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFG 197
Query: 191 TLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRA 250
T + D + H + + + +L L+SF + + P+ R
Sbjct: 198 TPVDSWQAPEDPFVKHCKRFFEFCIPRPILVL----LLSFPSIMVPLARILPNKNR---- 249
Query: 251 CQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDE-DDIKLSDADLRAE 309
+ +++IR AL+D++ ++ R DFL ++L AR + + D D+ +
Sbjct: 250 -DELNGFFNKLIRN-VIALRDQQAAEE----RRRDFLQMVLDARHSASPMGVQDFDIVRD 303
Query: 310 VDT--------------------------------FMFEGHDTTTSGISWFLYCMALYPE 337
V + F+ G++ T+ +S+ Y +A P+
Sbjct: 304 VFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPD 363
Query: 338 HQHRCREEV---REILGDQDFFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTF 394
Q + EV +E +F ++ + YL M I E+ R+YPP + R+ ++
Sbjct: 364 CQEKLLREVDVFKEKHMAPEFCSLEE--GLPYLDMVIAETLRMYPPAFRFTREAAQDCEV 421
Query: 395 VDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNC 454
+ G+ +PAG+++ M + ALH + WP PE F+ RF+ E + PF ++PF AGPR+C
Sbjct: 422 L-GQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSC 480
Query: 455 IGQQFAMSEMKVVTAMCLLRFEFSLDP-SRLPIKM-PQLVLRSKNGFHLHL 503
+G + + E+K+ L +F F P +++P+++ + L KNG ++ +
Sbjct: 481 LGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKI 531
>gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide 1
[Homo sapiens]
Length = 501
Score = 110 bits (274), Expect = 4e-24
Identities = 93/367 (25%), Positives = 151/367 (41%), Gaps = 17/367 (4%)
Query: 131 GPKWLQHRKLLTPGFHYDVL--KPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMA 188
G W+ HR+L F Y K + + E T+ D E +G+ FD + +
Sbjct: 130 GRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIE--TYKGRPFDFKQLITNAV 187
Query: 189 LNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGR--R 246
N FG T D + + + + + F Y+ + P G+ +
Sbjct: 188 SNITNLIIFGERFTY--EDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQ 245
Query: 247 FLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHL--DFLDILLGARDEDDIKLSDA 304
R V +D ++I + V +K Q +H +LD + +++ S
Sbjct: 246 LFRNAAVVYDFLSRLIEKAS-------VNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKE 298
Query: 305 DLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKM 364
+L V + G +TTT+ + W + MALYP Q + ++E+ I+G WDD KM
Sbjct: 299 NLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKM 358
Query: 365 TYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPE 424
Y + E R VP + V G S+P G+ + ++Y++H + W DPE
Sbjct: 359 PYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPE 418
Query: 425 VFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRL 484
VF RF + A +PFS G R+C+G+ A EM + L RF +
Sbjct: 419 VFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELV 478
Query: 485 PIKMPQL 491
P P+L
Sbjct: 479 PDLKPRL 485
>gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 3 [Homo sapiens]
Length = 420
Score = 99.8 bits (247), Expect = 5e-21
Identities = 84/356 (23%), Positives = 161/356 (45%), Gaps = 44/356 (12%)
Query: 92 LNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGRG--------LLVLEGPKWLQHRKLLTP 143
L I +PD K V + + Y F + G L E +W + R LL+P
Sbjct: 82 LVIMDPDMIKTVLVK------ECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSP 135
Query: 144 GFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTG 203
F K V + ++ +++ ++A KS ++ G ++ + FG
Sbjct: 136 AFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDS 195
Query: 204 LGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIY------WLTPHGRRF---LRACQVA 254
L + +D L ++L+ + + F+ +LTP L V
Sbjct: 196 LNNPQDPF---------LKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVT 246
Query: 255 HDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK----LSDADLRAEV 310
H + + R +++ L+D++ + +DF ++ +++ + K LSD +L A+
Sbjct: 247 HFLKNSIERMKESRLKDKQ-------KHRVDFFQQMIDSQNSKETKSHKALSDLELVAQS 299
Query: 311 DTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMC 370
+F +DTT++ + + +Y +A +P+ Q + +EE+ +L ++ +D L +M YL M
Sbjct: 300 IIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMV 359
Query: 371 IKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVF 426
+ E+ RL+P V +V R K + ++G +P G + + IYALH + W +PE F
Sbjct: 360 VNETLRLFPVVSRVTRVCKKDIE-INGVFIPKGLAVMVPIYALHHDPKYWTEPEKF 414
>gi|239757171 PREDICTED: similar to cytochrome P450, family 4,
subfamily F, polypeptide 2 [Homo sapiens]
Length = 190
Score = 99.4 bits (246), Expect = 7e-21
Identities = 56/156 (35%), Positives = 86/156 (55%), Gaps = 6/156 (3%)
Query: 140 LLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKS-FDIFCDVGHMALNTLMKCTFG 198
+L P FH+++LKPY+ +F ES IM KW E + D+F + M L++L KC F
Sbjct: 1 MLMPAFHFNILKPYMKIFDESVNIMHAKWHLLTLEHNACLDMFEHMNLMTLDSLQKCVFS 60
Query: 199 RGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHT 258
+ S Y +V +L+ L+ +R H DF+Y+LT GR F RAC++ HD
Sbjct: 61 FDSQC--QEKPSEYIASVLELSSLVAKRNQQILLHMDFLYYLTHDGRHFHRACRLGHDFA 118
Query: 259 DQVIRERKAALQDEKVRKKIQNR---RHLDFLDILL 291
D I+E++ L + V +Q + + LDF+D+LL
Sbjct: 119 DAAIQEKRHTLPSQGVDDFLQAKAKSKTLDFIDVLL 154
>gi|239751683 PREDICTED: similar to cytochrome P450, family 4,
subfamily F, polypeptide 2 [Homo sapiens]
Length = 190
Score = 99.4 bits (246), Expect = 7e-21
Identities = 56/156 (35%), Positives = 86/156 (55%), Gaps = 6/156 (3%)
Query: 140 LLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKS-FDIFCDVGHMALNTLMKCTFG 198
+L P FH+++LKPY+ +F ES IM KW E + D+F + M L++L KC F
Sbjct: 1 MLMPAFHFNILKPYMKIFDESVNIMHAKWHLLTLEHNACLDMFEHMNLMTLDSLQKCVFS 60
Query: 199 RGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHT 258
+ S Y +V +L+ L+ +R H DF+Y+LT GR F RAC++ HD
Sbjct: 61 FDSQC--QEKPSEYIASVLELSSLVAKRNQQILLHMDFLYYLTHDGRHFHRACRLGHDFA 118
Query: 259 DQVIRERKAALQDEKVRKKIQNR---RHLDFLDILL 291
D I+E++ L + V +Q + + LDF+D+LL
Sbjct: 119 DAAIQEKRHTLPSQGVDDFLQAKAKSKTLDFIDVLL 154
>gi|239746187 PREDICTED: similar to cytochrome P450, family 4,
subfamily F, polypeptide 2 [Homo sapiens]
Length = 190
Score = 99.4 bits (246), Expect = 7e-21
Identities = 56/156 (35%), Positives = 86/156 (55%), Gaps = 6/156 (3%)
Query: 140 LLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKS-FDIFCDVGHMALNTLMKCTFG 198
+L P FH+++LKPY+ +F ES IM KW E + D+F + M L++L KC F
Sbjct: 1 MLMPAFHFNILKPYMKIFDESVNIMHAKWHLLTLEHNACLDMFEHMNLMTLDSLQKCVFS 60
Query: 199 RGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHT 258
+ S Y +V +L+ L+ +R H DF+Y+LT GR F RAC++ HD
Sbjct: 61 FDSQC--QEKPSEYIASVLELSSLVAKRNQQILLHMDFLYYLTHDGRHFHRACRLGHDFA 118
Query: 259 DQVIRERKAALQDEKVRKKIQNR---RHLDFLDILL 291
D I+E++ L + V +Q + + LDF+D+LL
Sbjct: 119 DAAIQEKRHTLPSQGVDDFLQAKAKSKTLDFIDVLL 154
>gi|225903399 cytochrome P450, family 51, subfamily A, polypeptide 1
isoform 2 [Homo sapiens]
Length = 404
Score = 98.6 bits (244), Expect = 1e-20
Identities = 91/383 (23%), Positives = 165/383 (43%), Gaps = 31/383 (8%)
Query: 108 DPKAPDVYDFFLQWI-GRGLLV-LEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIML 165
D A DVY + G+G+ + P +L+ +K+L G + K +V++ + T+
Sbjct: 25 DLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYF 84
Query: 166 DKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQ 225
+ W E + ++F + + + T C G+ + + + Y +
Sbjct: 85 ESWGESGEK----NVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDG------- 133
Query: 226 RLVSFQYHNDFIY-WLT-PHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRH 283
F + + WL P RR RA + D + I++R+ + ++KI
Sbjct: 134 ---GFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQS------QEKID---- 180
Query: 284 LDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCR 343
D L LL A +D L+D ++ + + G T+++ +W + +A Q +C
Sbjct: 181 -DILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCY 239
Query: 344 EEVREILGDQ-DFFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPA 402
E + + G+ +D L + L CIKE+ RL PP+ + R P T V G ++P
Sbjct: 240 LEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQT-VAGYTIPP 298
Query: 403 GSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMS 462
G + + R W + F+ R+ +N + FA++PF AG CIG+ FA
Sbjct: 299 GHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYV 358
Query: 463 EMKVVTAMCLLRFEFSLDPSRLP 485
++K + + L +EF L P
Sbjct: 359 QIKTIWSTMLRLYEFDLIDGYFP 381
>gi|4503243 cytochrome P450, family 51, subfamily A, polypeptide 1
isoform 1 [Homo sapiens]
Length = 509
Score = 98.6 bits (244), Expect = 1e-20
Identities = 91/383 (23%), Positives = 165/383 (43%), Gaps = 31/383 (8%)
Query: 108 DPKAPDVYDFFLQWI-GRGLLV-LEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIML 165
D A DVY + G+G+ + P +L+ +K+L G + K +V++ + T+
Sbjct: 130 DLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYF 189
Query: 166 DKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQ 225
+ W E + ++F + + + T C G+ + + + Y +
Sbjct: 190 ESWGESGEK----NVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDG------- 238
Query: 226 RLVSFQYHNDFIY-WLT-PHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRH 283
F + + WL P RR RA + D + I++R+ + ++KI
Sbjct: 239 ---GFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQS------QEKID---- 285
Query: 284 LDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCR 343
D L LL A +D L+D ++ + + G T+++ +W + +A Q +C
Sbjct: 286 -DILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCY 344
Query: 344 EEVREILGDQ-DFFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPA 402
E + + G+ +D L + L CIKE+ RL PP+ + R P T V G ++P
Sbjct: 345 LEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQT-VAGYTIPP 403
Query: 403 GSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMS 462
G + + R W + F+ R+ +N + FA++PF AG CIG+ FA
Sbjct: 404 GHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYV 463
Query: 463 EMKVVTAMCLLRFEFSLDPSRLP 485
++K + + L +EF L P
Sbjct: 464 QIKTIWSTMLRLYEFDLIDGYFP 486
>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
[Homo sapiens]
Length = 544
Score = 98.6 bits (244), Expect = 1e-20
Identities = 71/260 (27%), Positives = 123/260 (47%), Gaps = 20/260 (7%)
Query: 236 FIYWLTPHGRRFLRACQVAHDHTD---QVIRERKAALQDEKVRKKIQNRRHLDFLDILLG 292
++Y+L P G F Q+ D T ++I++ + +L E + DF+D+ L
Sbjct: 275 WLYYL-PFGP-FKELRQIEKDITSFLKKIIKDHQESLDRENPQ---------DFIDMYLL 323
Query: 293 ARDEDDIKLSDADLRAE-----VDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVR 347
+E+ S++ E + G DTTT+ + W L M+L P+ Q + EE+
Sbjct: 324 HMEEERKNNSNSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIE 383
Query: 348 EILGDQDFFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLIS 407
++G D +M Y I E RL VP ++ T + G ++P G+LI
Sbjct: 384 RVIGANRAPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLIL 443
Query: 408 MHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVV 467
+++++HR+ A+W PE F RF + F+PF G R C+G+Q A E+ ++
Sbjct: 444 PNLWSVHRDPAIWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLM 503
Query: 468 TAMCLLRFEFSL-DPSRLPI 486
+ F F+L + S+ P+
Sbjct: 504 FVSLMQSFAFALPEDSKKPL 523
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.326 0.141 0.451
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,074,311
Number of Sequences: 37866
Number of extensions: 942026
Number of successful extensions: 2519
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 72
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 2303
Number of HSP's gapped (non-prelim): 89
length of query: 512
length of database: 18,247,518
effective HSP length: 107
effective length of query: 405
effective length of database: 14,195,856
effective search space: 5749321680
effective search space used: 5749321680
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.