Search of human proteins with 148529025

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|148529025 pleckstrin homology domain containing, family G
(with RhoGef domain) member 4B [Homo sapiens]
         (1271 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|148529025 pleckstrin homology domain containing, family G (wi...  2567   0.0  
gi|193211603 pleckstrin homology domain containing, family G (wi...   427   e-119
gi|193211598 pleckstrin homology domain containing, family G (wi...   427   e-119
gi|193211596 pleckstrin homology domain containing, family G (wi...   427   e-119
gi|193211594 pleckstrin homology domain containing, family G (wi...   427   e-119
gi|55742734 pleckstrin homology domain containing, family G (wit...   427   e-119
gi|50843837 hypothetical protein LOC55701 [Homo sapiens]              378   e-104
gi|45439359 triple functional domain (PTPRF interacting) [Homo s...   204   6e-52
gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]          199   1e-50
gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens]            199   1e-50
gi|150417975 RhoA/RAC/CDC42 exchange factor isoform 1 [Homo sapi...   197   5e-50
gi|162287076 RhoA/RAC/CDC42 exchange factor isoform 3 [Homo sapi...   197   5e-50
gi|163644325 MCF.2 cell line derived transforming sequence-like ...   195   2e-49
gi|163644323 MCF.2 cell line derived transforming sequence-like ...   195   2e-49
gi|153791628 MCF.2 cell line derived transforming sequence isofo...   182   1e-45
gi|153791325 MCF.2 cell line derived transforming sequence isofo...   182   1e-45
gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens]           181   5e-45
gi|71274186 hypothetical protein LOC85449 [Homo sapiens]              179   1e-44
gi|31742505 Rho family guanine-nucleotide exchange factor [Homo ...   119   2e-26
gi|71274148 pleckstrin homology domain containing, family G (wit...   101   5e-21
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex...    83   2e-15
gi|58331253 obscurin, cytoskeletal calmodulin and titin-interact...    79   4e-14
gi|148833506 obscurin, cytoskeletal calmodulin and titin-interac...    79   4e-14
gi|55749621 pleckstrin homology domain containing, family G, mem...    72   3e-12
gi|23308553 spermatogenesis associated 13 [Homo sapiens]               70   1e-11
gi|39930351 dynamin binding protein [Homo sapiens]                     68   6e-11
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [...    67   1e-10
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R...    65   3e-10
gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]           63   2e-09
gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]           63   2e-09

>gi|148529025 pleckstrin homology domain containing, family G (with
            RhoGef domain) member 4B [Homo sapiens]
          Length = 1271

 Score = 2567 bits (6653), Expect = 0.0
 Identities = 1271/1271 (100%), Positives = 1271/1271 (100%)

Query: 1    MEALRNPMPLGSSEEALGDLACSSLTGASRDLGTGAVASGTQEETSGPRGDPQQTPSLEK 60
            MEALRNPMPLGSSEEALGDLACSSLTGASRDLGTGAVASGTQEETSGPRGDPQQTPSLEK
Sbjct: 1    MEALRNPMPLGSSEEALGDLACSSLTGASRDLGTGAVASGTQEETSGPRGDPQQTPSLEK 60

Query: 61   ERHTPSRTGPGAAGRTLPRRSRSWERAPRSSRGAQAAACHTSHHSAGSRPGGHLGGQAVG 120
            ERHTPSRTGPGAAGRTLPRRSRSWERAPRSSRGAQAAACHTSHHSAGSRPGGHLGGQAVG
Sbjct: 61   ERHTPSRTGPGAAGRTLPRRSRSWERAPRSSRGAQAAACHTSHHSAGSRPGGHLGGQAVG 120

Query: 121  TPNCVPVEGPGCTKEEDVLASSACVSTDGGSLHCHNPSGPSDVPARQPHPEQEGWPPGTG 180
            TPNCVPVEGPGCTKEEDVLASSACVSTDGGSLHCHNPSGPSDVPARQPHPEQEGWPPGTG
Sbjct: 121  TPNCVPVEGPGCTKEEDVLASSACVSTDGGSLHCHNPSGPSDVPARQPHPEQEGWPPGTG 180

Query: 181  DFPSQVPKQVLDVSQELLQSGVVTLPGTRDRHGRAVVQVRTRSLLWTREHSSCAELTRLL 240
            DFPSQVPKQVLDVSQELLQSGVVTLPGTRDRHGRAVVQVRTRSLLWTREHSSCAELTRLL
Sbjct: 181  DFPSQVPKQVLDVSQELLQSGVVTLPGTRDRHGRAVVQVRTRSLLWTREHSSCAELTRLL 240

Query: 241  LYFHSIPRKEVRDLGLVVLVDARRSPAAPAVSQALSGLQNNTSPIIHSILLLVDKESAFR 300
            LYFHSIPRKEVRDLGLVVLVDARRSPAAPAVSQALSGLQNNTSPIIHSILLLVDKESAFR
Sbjct: 241  LYFHSIPRKEVRDLGLVVLVDARRSPAAPAVSQALSGLQNNTSPIIHSILLLVDKESAFR 300

Query: 301  PDKDAIIQCEVVSSLKAVHKFVDSCQLTADLDGSFPYSHGDWICFRQRLEHFAANCEEAI 360
            PDKDAIIQCEVVSSLKAVHKFVDSCQLTADLDGSFPYSHGDWICFRQRLEHFAANCEEAI
Sbjct: 301  PDKDAIIQCEVVSSLKAVHKFVDSCQLTADLDGSFPYSHGDWICFRQRLEHFAANCEEAI 360

Query: 361  IFLQNSFCSLNTHRTPRTAQEVAELIDQHETMMKLVLEDPLLVSLRLEGGTVLARLRREE 420
            IFLQNSFCSLNTHRTPRTAQEVAELIDQHETMMKLVLEDPLLVSLRLEGGTVLARLRREE
Sbjct: 361  IFLQNSFCSLNTHRTPRTAQEVAELIDQHETMMKLVLEDPLLVSLRLEGGTVLARLRREE 420

Query: 421  LGTEDSRDTLEAATSLYDRVDEEVHRLVLTSNNRLQQLEHLRELASLLEGNDQQSCQKGL 480
            LGTEDSRDTLEAATSLYDRVDEEVHRLVLTSNNRLQQLEHLRELASLLEGNDQQSCQKGL
Sbjct: 421  LGTEDSRDTLEAATSLYDRVDEEVHRLVLTSNNRLQQLEHLRELASLLEGNDQQSCQKGL 480

Query: 481  QLAKENPQRTEEMVQDFRRGLSAVVSQAECREGELARWTRSSELCETVSSWMGPLDPEAC 540
            QLAKENPQRTEEMVQDFRRGLSAVVSQAECREGELARWTRSSELCETVSSWMGPLDPEAC
Sbjct: 481  QLAKENPQRTEEMVQDFRRGLSAVVSQAECREGELARWTRSSELCETVSSWMGPLDPEAC 540

Query: 541  PSSPVAECLRSCHQEATSVAAEAFPGAGVAVLKPHALGKPWASQQDLWLQYPQTRLRLEE 600
            PSSPVAECLRSCHQEATSVAAEAFPGAGVAVLKPHALGKPWASQQDLWLQYPQTRLRLEE
Sbjct: 541  PSSPVAECLRSCHQEATSVAAEAFPGAGVAVLKPHALGKPWASQQDLWLQYPQTRLRLEE 600

Query: 601  ALSEAAPDPSLPPLAQSPPKHERAQEAMRRHQKPPSFPSTDSGGGAWEPAQPLSGLPGRA 660
            ALSEAAPDPSLPPLAQSPPKHERAQEAMRRHQKPPSFPSTDSGGGAWEPAQPLSGLPGRA
Sbjct: 601  ALSEAAPDPSLPPLAQSPPKHERAQEAMRRHQKPPSFPSTDSGGGAWEPAQPLSGLPGRA 660

Query: 661  LLCGQDGETLRPGLCALWDPLSLLRGLPGAGATTAHLEDSSACSSEPTQTLASRPRKHPQ 720
            LLCGQDGETLRPGLCALWDPLSLLRGLPGAGATTAHLEDSSACSSEPTQTLASRPRKHPQ
Sbjct: 661  LLCGQDGETLRPGLCALWDPLSLLRGLPGAGATTAHLEDSSACSSEPTQTLASRPRKHPQ 720

Query: 721  KKMIKKTQSFEIPQPDSGPRDSCQPDHTSVFSKGLEVTSTVATEKKLPLWQHARSPPVTQ 780
            KKMIKKTQSFEIPQPDSGPRDSCQPDHTSVFSKGLEVTSTVATEKKLPLWQHARSPPVTQ
Sbjct: 721  KKMIKKTQSFEIPQPDSGPRDSCQPDHTSVFSKGLEVTSTVATEKKLPLWQHARSPPVTQ 780

Query: 781  SRSLSSPSGLHPAEEDGRQQVGSSRLRHIMAEMIATEREYIRCLGYVIDNYFPEMERMDL 840
            SRSLSSPSGLHPAEEDGRQQVGSSRLRHIMAEMIATEREYIRCLGYVIDNYFPEMERMDL
Sbjct: 781  SRSLSSPSGLHPAEEDGRQQVGSSRLRHIMAEMIATEREYIRCLGYVIDNYFPEMERMDL 840

Query: 841  PQGLRGKHHVIFGNLEKLHDFHQQHFLRELERCQHCPLAVGRSFLRHEEQFGMYVIYSKN 900
            PQGLRGKHHVIFGNLEKLHDFHQQHFLRELERCQHCPLAVGRSFLRHEEQFGMYVIYSKN
Sbjct: 841  PQGLRGKHHVIFGNLEKLHDFHQQHFLRELERCQHCPLAVGRSFLRHEEQFGMYVIYSKN 900

Query: 901  KPQSDALLSSHGNAFFKDKQRELGDKMDLASYLLRPVQRVAKYALLLQDLLKEASCGLAQ 960
            KPQSDALLSSHGNAFFKDKQRELGDKMDLASYLLRPVQRVAKYALLLQDLLKEASCGLAQ
Sbjct: 901  KPQSDALLSSHGNAFFKDKQRELGDKMDLASYLLRPVQRVAKYALLLQDLLKEASCGLAQ 960

Query: 961  GQELGELRAAEVVVCFQLRHGNDLLAMDAIRGCDVNLKEQGQLRCRDEFIVCCGRKKYLR 1020
            GQELGELRAAEVVVCFQLRHGNDLLAMDAIRGCDVNLKEQGQLRCRDEFIVCCGRKKYLR
Sbjct: 961  GQELGELRAAEVVVCFQLRHGNDLLAMDAIRGCDVNLKEQGQLRCRDEFIVCCGRKKYLR 1020

Query: 1021 HVFLFEDLILFSKTQKVEGSHDVYLYKQSFKTAEIGMTENVGDSGLRFEIWFRRRRKSQD 1080
            HVFLFEDLILFSKTQKVEGSHDVYLYKQSFKTAEIGMTENVGDSGLRFEIWFRRRRKSQD
Sbjct: 1021 HVFLFEDLILFSKTQKVEGSHDVYLYKQSFKTAEIGMTENVGDSGLRFEIWFRRRRKSQD 1080

Query: 1081 TYILQASSAEVKSAWTDVIGRILWRQALKSRELRIQEMASMGIGNQPFMDVKPRDRTPDC 1140
            TYILQASSAEVKSAWTDVIGRILWRQALKSRELRIQEMASMGIGNQPFMDVKPRDRTPDC
Sbjct: 1081 TYILQASSAEVKSAWTDVIGRILWRQALKSRELRIQEMASMGIGNQPFMDVKPRDRTPDC 1140

Query: 1141 AVISDRAPKCAVMSDRVPDSIVKGTESQMRGSTAVSSSDHAAPFKRPHSTISDSSTSSSS 1200
            AVISDRAPKCAVMSDRVPDSIVKGTESQMRGSTAVSSSDHAAPFKRPHSTISDSSTSSSS
Sbjct: 1141 AVISDRAPKCAVMSDRVPDSIVKGTESQMRGSTAVSSSDHAAPFKRPHSTISDSSTSSSS 1200

Query: 1201 SQSSSILGSLGLLVSSSPAHPGLWSPAHSPWSSDIRACVEEDEPEPELETGTQAAVCEGA 1260
            SQSSSILGSLGLLVSSSPAHPGLWSPAHSPWSSDIRACVEEDEPEPELETGTQAAVCEGA
Sbjct: 1201 SQSSSILGSLGLLVSSSPAHPGLWSPAHSPWSSDIRACVEEDEPEPELETGTQAAVCEGA 1260

Query: 1261 PAVLLSRTRQA 1271
            PAVLLSRTRQA
Sbjct: 1261 PAVLLSRTRQA 1271


>gi|193211603 pleckstrin homology domain containing, family G (with
            RhoGef domain) member 4 isoform 2 [Homo sapiens]
          Length = 1110

 Score =  427 bits (1099), Expect = e-119
 Identities = 235/472 (49%), Positives = 313/472 (66%), Gaps = 35/472 (7%)

Query: 785  SSPSGLHPAEEDGRQQVGSSRLRHIMAEMIATEREYIRCLGYVIDNYFPEMERMDLPQGL 844
            +SP+   P   D R     +RL+ ++AEM+ATEREY+R L Y ++NYFPE++R D+PQGL
Sbjct: 634  ASPTVPPPGSSDPRSL---NRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGL 690

Query: 845  RGKHHVIFGNLEKLHDFHQQHFLRELERCQHCPLAVGRSFLRHEEQFGMYVIYSKNKPQS 904
            RG+   +FGNLEKL DFH   FLRELE C   P  V  +FLRH  QFGMY +YSKNKP+S
Sbjct: 691  RGQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRS 750

Query: 905  DALLSSHGNAFFKDKQRELGDKMDLASYLLRPVQRVAKYALLLQDLLKEASCGLAQGQEL 964
            DAL+SS+G+ FFKDKQ+ LGD +DLASYLL+P+QR+ KYALLLQ+L +  +CG    QEL
Sbjct: 751  DALMSSYGHTFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELAR--ACG-GPTQEL 807

Query: 965  GELRAAEVVVCFQLRHGNDLLAMDAIRGCDVNLKEQGQLRCRDEFIVCCGRKKYLRHVFL 1024
              LR A+ +V FQLRHGNDLLAMDAI+GCDVNLKEQGQL  +DEF+V  GR K +R +FL
Sbjct: 808  SALREAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFL 867

Query: 1025 FEDLILFSKTQKVEGSHDVYLYKQSFKTAEIGMTENVGDSGLRFEIWFRRRRKSQDTYIL 1084
            FE+L+LFSK +      D + YK+SFK A++G+TE  G+S LRFEIWF RRRK++DT++L
Sbjct: 868  FEELLLFSKPRHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWF-RRRKARDTFVL 926

Query: 1085 QASSAEVKSAWTDVIGRILWRQALKSRELRIQEMASMGIGNQPFMDVKPRDRTPDCAVIS 1144
            QASS  +K AWT  I  +LWRQA+ ++E+R+ EM SMG+GN+ F D+ P +         
Sbjct: 927  QASSLAIKQAWTADISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEE-------- 978

Query: 1145 DRAPKCAVMSDRVPDSIVKGTESQMRGSTAVSSSDHAAPFKRPHSTISDSSTSSSSSQSS 1204
                    ++DR  + ++K  E + R S AV+  DH + +      +  S++      S 
Sbjct: 979  -------AINDRTVNYVLKCREVRSRASIAVAPFDHDSLY------LGASNSLPGDPASC 1025

Query: 1205 SILGSLGLLVSSSPAHPGLWSPAHSPWSSDIRACVEEDEPEPELETGTQAAV 1256
            S+LGSL L +   PA  GL  P +  +        EE   E E E G Q ++
Sbjct: 1026 SVLGSLNLHLYRDPALLGLRCPLYPSFP-------EEAALEAEAELGGQPSL 1070



 Score =  152 bits (384), Expect = 2e-36
 Identities = 108/316 (34%), Positives = 161/316 (50%), Gaps = 12/316 (3%)

Query: 207 GTRDRHGRAVVQVRTRSLLWTREHSSCAELTRLLLYFHSIPRKEVRDLGLVVLVDARRSP 266
           GTRD  GRAV+ +   S  W +   S  EL RLLLY  SIPR EV+ LGL VLVDAR   
Sbjct: 118 GTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALGLTVLVDARICA 177

Query: 267 AAPAVSQALSGLQNNTSPIIHSILLLVDKESAFRPDKDAIIQCEVVSSLKAVHKFVDSCQ 326
            + ++   LS LQ      ++ +LL+    S    +  + +Q E + S +++   + +  
Sbjct: 178 PSSSLFSGLSQLQEAAPGAVYQVLLV---GSTLLKEVPSGLQLEQLPS-QSLLTHIPTAG 233

Query: 327 LTADLDGSFPYSHGDWICFRQRLEHFAANCEEAIIFLQNSFCSLNTHRTPRTAQEVAELI 386
           L   L G  PY H  W+ FR+RLE    NC+ A   LQ +  S+     P    EV +L+
Sbjct: 234 LPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKAVPQPMEPGEVGQLL 293

Query: 387 DQHETMMKLVLEDPLLVSLRLEGGTVLARLRR---EELGTEDSRDTLEAATSLYDRVDEE 443
            Q E +M+ VL+ P L  L+ +GG  L  L++   E   + D R  ++ A  LYDRVD  
Sbjct: 294 QQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTAMDKADELYDRVDGL 353

Query: 444 VHRLVLTSNNRLQQLEHLRELASLLEGNDQQSC---QKGLQLAKENPQRTEEMVQDFRRG 500
           +H+L L SN R+Q LE ++ L +   G  Q      Q G    +E  + + +M+   +  
Sbjct: 354 LHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEAGEPSLDMLLQAQGS 413

Query: 501 LSAV--VSQAECREGE 514
              +  V+Q + R+GE
Sbjct: 414 FQELYQVAQEQVRQGE 429


>gi|193211598 pleckstrin homology domain containing, family G (with
            RhoGef domain) member 4 isoform 1 [Homo sapiens]
          Length = 1191

 Score =  427 bits (1099), Expect = e-119
 Identities = 235/472 (49%), Positives = 313/472 (66%), Gaps = 35/472 (7%)

Query: 785  SSPSGLHPAEEDGRQQVGSSRLRHIMAEMIATEREYIRCLGYVIDNYFPEMERMDLPQGL 844
            +SP+   P   D R     +RL+ ++AEM+ATEREY+R L Y ++NYFPE++R D+PQGL
Sbjct: 715  ASPTVPPPGSSDPRSL---NRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGL 771

Query: 845  RGKHHVIFGNLEKLHDFHQQHFLRELERCQHCPLAVGRSFLRHEEQFGMYVIYSKNKPQS 904
            RG+   +FGNLEKL DFH   FLRELE C   P  V  +FLRH  QFGMY +YSKNKP+S
Sbjct: 772  RGQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRS 831

Query: 905  DALLSSHGNAFFKDKQRELGDKMDLASYLLRPVQRVAKYALLLQDLLKEASCGLAQGQEL 964
            DAL+SS+G+ FFKDKQ+ LGD +DLASYLL+P+QR+ KYALLLQ+L +  +CG    QEL
Sbjct: 832  DALMSSYGHTFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELAR--ACG-GPTQEL 888

Query: 965  GELRAAEVVVCFQLRHGNDLLAMDAIRGCDVNLKEQGQLRCRDEFIVCCGRKKYLRHVFL 1024
              LR A+ +V FQLRHGNDLLAMDAI+GCDVNLKEQGQL  +DEF+V  GR K +R +FL
Sbjct: 889  SALREAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFL 948

Query: 1025 FEDLILFSKTQKVEGSHDVYLYKQSFKTAEIGMTENVGDSGLRFEIWFRRRRKSQDTYIL 1084
            FE+L+LFSK +      D + YK+SFK A++G+TE  G+S LRFEIWF RRRK++DT++L
Sbjct: 949  FEELLLFSKPRHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWF-RRRKARDTFVL 1007

Query: 1085 QASSAEVKSAWTDVIGRILWRQALKSRELRIQEMASMGIGNQPFMDVKPRDRTPDCAVIS 1144
            QASS  +K AWT  I  +LWRQA+ ++E+R+ EM SMG+GN+ F D+ P +         
Sbjct: 1008 QASSLAIKQAWTADISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEE-------- 1059

Query: 1145 DRAPKCAVMSDRVPDSIVKGTESQMRGSTAVSSSDHAAPFKRPHSTISDSSTSSSSSQSS 1204
                    ++DR  + ++K  E + R S AV+  DH + +      +  S++      S 
Sbjct: 1060 -------AINDRTVNYVLKCREVRSRASIAVAPFDHDSLY------LGASNSLPGDPASC 1106

Query: 1205 SILGSLGLLVSSSPAHPGLWSPAHSPWSSDIRACVEEDEPEPELETGTQAAV 1256
            S+LGSL L +   PA  GL  P +  +        EE   E E E G Q ++
Sbjct: 1107 SVLGSLNLHLYRDPALLGLRCPLYPSFP-------EEAALEAEAELGGQPSL 1151



 Score =  173 bits (438), Expect = 1e-42
 Identities = 153/490 (31%), Positives = 223/490 (45%), Gaps = 45/490 (9%)

Query: 38  ASGTQEETSGPRGDPQQTPSLEKERHTPSRTGPGAAGRTLPRRSRSWERAPRSSRGAQAA 97
           A  TQ+E      + Q +P   K +  P+    G A R     S      P  S G ++ 
Sbjct: 53  AGATQDE------ELQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPS-GVESL 105

Query: 98  ACHTSHHSAGSRPGGHLGGQAVGTPNCVPVEGPGCTKEEDVLASSACVSTDGGSLHCHNP 157
            C  S H +       L      TP    V  PG ++      S   + +D        P
Sbjct: 106 LCPMSSHLS-------LAQGESDTPGVGLVGDPGPSRAMPSGLSPGALDSD--------P 150

Query: 158 SGPSDVPARQPHPEQEGWPPGTGDFPSQVPKQV-----LDVSQELLQSGVVTLPGTRDRH 212
            G  D P  +     E  P G+G     +PK        D+  ELL SG+ TLPGTRD  
Sbjct: 151 VGLGD-PLSEISKLLEAAPSGSG-----LPKPADCLLAQDLCWELLASGMATLPGTRDVQ 204

Query: 213 GRAVVQVRTRSLLWTREHSSCAELTRLLLYFHSIPRKEVRDLGLVVLVDARRSPAAPAVS 272
           GRAV+ +   S  W +   S  EL RLLLY  SIPR EV+ LGL VLVDAR    + ++ 
Sbjct: 205 GRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALGLTVLVDARICAPSSSLF 264

Query: 273 QALSGLQNNTSPIIHSILLLVDKESAFRPDKDAIIQCEVVSSLKAVHKFVDSCQLTADLD 332
             LS LQ      ++ +LL+    S    +  + +Q E + S +++   + +  L   L 
Sbjct: 265 SGLSQLQEAAPGAVYQVLLV---GSTLLKEVPSGLQLEQLPS-QSLLTHIPTAGLPTSLG 320

Query: 333 GSFPYSHGDWICFRQRLEHFAANCEEAIIFLQNSFCSLNTHRTPRTAQEVAELIDQHETM 392
           G  PY H  W+ FR+RLE    NC+ A   LQ +  S+     P    EV +L+ Q E +
Sbjct: 321 GGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKAVPQPMEPGEVGQLLQQTEVL 380

Query: 393 MKLVLEDPLLVSLRLEGGTVLARLRR---EELGTEDSRDTLEAATSLYDRVDEEVHRLVL 449
           M+ VL+ P L  L+ +GG  L  L++   E   + D R  ++ A  LYDRVD  +H+L L
Sbjct: 381 MQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTAMDKADELYDRVDGLLHQLTL 440

Query: 450 TSNNRLQQLEHLRELASLLEGNDQQSC---QKGLQLAKENPQRTEEMVQDFRRGLSAV-- 504
            SN R+Q LE ++ L +   G  Q      Q G    +E  + + +M+   +     +  
Sbjct: 441 QSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEAGEPSLDMLLQAQGSFQELYQ 500

Query: 505 VSQAECREGE 514
           V+Q + R+GE
Sbjct: 501 VAQEQVRQGE 510


>gi|193211596 pleckstrin homology domain containing, family G (with
            RhoGef domain) member 4 isoform 1 [Homo sapiens]
          Length = 1191

 Score =  427 bits (1099), Expect = e-119
 Identities = 235/472 (49%), Positives = 313/472 (66%), Gaps = 35/472 (7%)

Query: 785  SSPSGLHPAEEDGRQQVGSSRLRHIMAEMIATEREYIRCLGYVIDNYFPEMERMDLPQGL 844
            +SP+   P   D R     +RL+ ++AEM+ATEREY+R L Y ++NYFPE++R D+PQGL
Sbjct: 715  ASPTVPPPGSSDPRSL---NRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGL 771

Query: 845  RGKHHVIFGNLEKLHDFHQQHFLRELERCQHCPLAVGRSFLRHEEQFGMYVIYSKNKPQS 904
            RG+   +FGNLEKL DFH   FLRELE C   P  V  +FLRH  QFGMY +YSKNKP+S
Sbjct: 772  RGQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRS 831

Query: 905  DALLSSHGNAFFKDKQRELGDKMDLASYLLRPVQRVAKYALLLQDLLKEASCGLAQGQEL 964
            DAL+SS+G+ FFKDKQ+ LGD +DLASYLL+P+QR+ KYALLLQ+L +  +CG    QEL
Sbjct: 832  DALMSSYGHTFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELAR--ACG-GPTQEL 888

Query: 965  GELRAAEVVVCFQLRHGNDLLAMDAIRGCDVNLKEQGQLRCRDEFIVCCGRKKYLRHVFL 1024
              LR A+ +V FQLRHGNDLLAMDAI+GCDVNLKEQGQL  +DEF+V  GR K +R +FL
Sbjct: 889  SALREAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFL 948

Query: 1025 FEDLILFSKTQKVEGSHDVYLYKQSFKTAEIGMTENVGDSGLRFEIWFRRRRKSQDTYIL 1084
            FE+L+LFSK +      D + YK+SFK A++G+TE  G+S LRFEIWF RRRK++DT++L
Sbjct: 949  FEELLLFSKPRHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWF-RRRKARDTFVL 1007

Query: 1085 QASSAEVKSAWTDVIGRILWRQALKSRELRIQEMASMGIGNQPFMDVKPRDRTPDCAVIS 1144
            QASS  +K AWT  I  +LWRQA+ ++E+R+ EM SMG+GN+ F D+ P +         
Sbjct: 1008 QASSLAIKQAWTADISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEE-------- 1059

Query: 1145 DRAPKCAVMSDRVPDSIVKGTESQMRGSTAVSSSDHAAPFKRPHSTISDSSTSSSSSQSS 1204
                    ++DR  + ++K  E + R S AV+  DH + +      +  S++      S 
Sbjct: 1060 -------AINDRTVNYVLKCREVRSRASIAVAPFDHDSLY------LGASNSLPGDPASC 1106

Query: 1205 SILGSLGLLVSSSPAHPGLWSPAHSPWSSDIRACVEEDEPEPELETGTQAAV 1256
            S+LGSL L +   PA  GL  P +  +        EE   E E E G Q ++
Sbjct: 1107 SVLGSLNLHLYRDPALLGLRCPLYPSFP-------EEAALEAEAELGGQPSL 1151



 Score =  173 bits (438), Expect = 1e-42
 Identities = 153/490 (31%), Positives = 223/490 (45%), Gaps = 45/490 (9%)

Query: 38  ASGTQEETSGPRGDPQQTPSLEKERHTPSRTGPGAAGRTLPRRSRSWERAPRSSRGAQAA 97
           A  TQ+E      + Q +P   K +  P+    G A R     S      P  S G ++ 
Sbjct: 53  AGATQDE------ELQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPS-GVESL 105

Query: 98  ACHTSHHSAGSRPGGHLGGQAVGTPNCVPVEGPGCTKEEDVLASSACVSTDGGSLHCHNP 157
            C  S H +       L      TP    V  PG ++      S   + +D        P
Sbjct: 106 LCPMSSHLS-------LAQGESDTPGVGLVGDPGPSRAMPSGLSPGALDSD--------P 150

Query: 158 SGPSDVPARQPHPEQEGWPPGTGDFPSQVPKQV-----LDVSQELLQSGVVTLPGTRDRH 212
            G  D P  +     E  P G+G     +PK        D+  ELL SG+ TLPGTRD  
Sbjct: 151 VGLGD-PLSEISKLLEAAPSGSG-----LPKPADCLLAQDLCWELLASGMATLPGTRDVQ 204

Query: 213 GRAVVQVRTRSLLWTREHSSCAELTRLLLYFHSIPRKEVRDLGLVVLVDARRSPAAPAVS 272
           GRAV+ +   S  W +   S  EL RLLLY  SIPR EV+ LGL VLVDAR    + ++ 
Sbjct: 205 GRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALGLTVLVDARICAPSSSLF 264

Query: 273 QALSGLQNNTSPIIHSILLLVDKESAFRPDKDAIIQCEVVSSLKAVHKFVDSCQLTADLD 332
             LS LQ      ++ +LL+    S    +  + +Q E + S +++   + +  L   L 
Sbjct: 265 SGLSQLQEAAPGAVYQVLLV---GSTLLKEVPSGLQLEQLPS-QSLLTHIPTAGLPTSLG 320

Query: 333 GSFPYSHGDWICFRQRLEHFAANCEEAIIFLQNSFCSLNTHRTPRTAQEVAELIDQHETM 392
           G  PY H  W+ FR+RLE    NC+ A   LQ +  S+     P    EV +L+ Q E +
Sbjct: 321 GGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKAVPQPMEPGEVGQLLQQTEVL 380

Query: 393 MKLVLEDPLLVSLRLEGGTVLARLRR---EELGTEDSRDTLEAATSLYDRVDEEVHRLVL 449
           M+ VL+ P L  L+ +GG  L  L++   E   + D R  ++ A  LYDRVD  +H+L L
Sbjct: 381 MQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTAMDKADELYDRVDGLLHQLTL 440

Query: 450 TSNNRLQQLEHLRELASLLEGNDQQSC---QKGLQLAKENPQRTEEMVQDFRRGLSAV-- 504
            SN R+Q LE ++ L +   G  Q      Q G    +E  + + +M+   +     +  
Sbjct: 441 QSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEAGEPSLDMLLQAQGSFQELYQ 500

Query: 505 VSQAECREGE 514
           V+Q + R+GE
Sbjct: 501 VAQEQVRQGE 510


>gi|193211594 pleckstrin homology domain containing, family G (with
            RhoGef domain) member 4 isoform 1 [Homo sapiens]
          Length = 1191

 Score =  427 bits (1099), Expect = e-119
 Identities = 235/472 (49%), Positives = 313/472 (66%), Gaps = 35/472 (7%)

Query: 785  SSPSGLHPAEEDGRQQVGSSRLRHIMAEMIATEREYIRCLGYVIDNYFPEMERMDLPQGL 844
            +SP+   P   D R     +RL+ ++AEM+ATEREY+R L Y ++NYFPE++R D+PQGL
Sbjct: 715  ASPTVPPPGSSDPRSL---NRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGL 771

Query: 845  RGKHHVIFGNLEKLHDFHQQHFLRELERCQHCPLAVGRSFLRHEEQFGMYVIYSKNKPQS 904
            RG+   +FGNLEKL DFH   FLRELE C   P  V  +FLRH  QFGMY +YSKNKP+S
Sbjct: 772  RGQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRS 831

Query: 905  DALLSSHGNAFFKDKQRELGDKMDLASYLLRPVQRVAKYALLLQDLLKEASCGLAQGQEL 964
            DAL+SS+G+ FFKDKQ+ LGD +DLASYLL+P+QR+ KYALLLQ+L +  +CG    QEL
Sbjct: 832  DALMSSYGHTFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELAR--ACG-GPTQEL 888

Query: 965  GELRAAEVVVCFQLRHGNDLLAMDAIRGCDVNLKEQGQLRCRDEFIVCCGRKKYLRHVFL 1024
              LR A+ +V FQLRHGNDLLAMDAI+GCDVNLKEQGQL  +DEF+V  GR K +R +FL
Sbjct: 889  SALREAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFL 948

Query: 1025 FEDLILFSKTQKVEGSHDVYLYKQSFKTAEIGMTENVGDSGLRFEIWFRRRRKSQDTYIL 1084
            FE+L+LFSK +      D + YK+SFK A++G+TE  G+S LRFEIWF RRRK++DT++L
Sbjct: 949  FEELLLFSKPRHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWF-RRRKARDTFVL 1007

Query: 1085 QASSAEVKSAWTDVIGRILWRQALKSRELRIQEMASMGIGNQPFMDVKPRDRTPDCAVIS 1144
            QASS  +K AWT  I  +LWRQA+ ++E+R+ EM SMG+GN+ F D+ P +         
Sbjct: 1008 QASSLAIKQAWTADISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEE-------- 1059

Query: 1145 DRAPKCAVMSDRVPDSIVKGTESQMRGSTAVSSSDHAAPFKRPHSTISDSSTSSSSSQSS 1204
                    ++DR  + ++K  E + R S AV+  DH + +      +  S++      S 
Sbjct: 1060 -------AINDRTVNYVLKCREVRSRASIAVAPFDHDSLY------LGASNSLPGDPASC 1106

Query: 1205 SILGSLGLLVSSSPAHPGLWSPAHSPWSSDIRACVEEDEPEPELETGTQAAV 1256
            S+LGSL L +   PA  GL  P +  +        EE   E E E G Q ++
Sbjct: 1107 SVLGSLNLHLYRDPALLGLRCPLYPSFP-------EEAALEAEAELGGQPSL 1151



 Score =  173 bits (438), Expect = 1e-42
 Identities = 153/490 (31%), Positives = 223/490 (45%), Gaps = 45/490 (9%)

Query: 38  ASGTQEETSGPRGDPQQTPSLEKERHTPSRTGPGAAGRTLPRRSRSWERAPRSSRGAQAA 97
           A  TQ+E      + Q +P   K +  P+    G A R     S      P  S G ++ 
Sbjct: 53  AGATQDE------ELQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPS-GVESL 105

Query: 98  ACHTSHHSAGSRPGGHLGGQAVGTPNCVPVEGPGCTKEEDVLASSACVSTDGGSLHCHNP 157
            C  S H +       L      TP    V  PG ++      S   + +D        P
Sbjct: 106 LCPMSSHLS-------LAQGESDTPGVGLVGDPGPSRAMPSGLSPGALDSD--------P 150

Query: 158 SGPSDVPARQPHPEQEGWPPGTGDFPSQVPKQV-----LDVSQELLQSGVVTLPGTRDRH 212
            G  D P  +     E  P G+G     +PK        D+  ELL SG+ TLPGTRD  
Sbjct: 151 VGLGD-PLSEISKLLEAAPSGSG-----LPKPADCLLAQDLCWELLASGMATLPGTRDVQ 204

Query: 213 GRAVVQVRTRSLLWTREHSSCAELTRLLLYFHSIPRKEVRDLGLVVLVDARRSPAAPAVS 272
           GRAV+ +   S  W +   S  EL RLLLY  SIPR EV+ LGL VLVDAR    + ++ 
Sbjct: 205 GRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALGLTVLVDARICAPSSSLF 264

Query: 273 QALSGLQNNTSPIIHSILLLVDKESAFRPDKDAIIQCEVVSSLKAVHKFVDSCQLTADLD 332
             LS LQ      ++ +LL+    S    +  + +Q E + S +++   + +  L   L 
Sbjct: 265 SGLSQLQEAAPGAVYQVLLV---GSTLLKEVPSGLQLEQLPS-QSLLTHIPTAGLPTSLG 320

Query: 333 GSFPYSHGDWICFRQRLEHFAANCEEAIIFLQNSFCSLNTHRTPRTAQEVAELIDQHETM 392
           G  PY H  W+ FR+RLE    NC+ A   LQ +  S+     P    EV +L+ Q E +
Sbjct: 321 GGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKAVPQPMEPGEVGQLLQQTEVL 380

Query: 393 MKLVLEDPLLVSLRLEGGTVLARLRR---EELGTEDSRDTLEAATSLYDRVDEEVHRLVL 449
           M+ VL+ P L  L+ +GG  L  L++   E   + D R  ++ A  LYDRVD  +H+L L
Sbjct: 381 MQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTAMDKADELYDRVDGLLHQLTL 440

Query: 450 TSNNRLQQLEHLRELASLLEGNDQQSC---QKGLQLAKENPQRTEEMVQDFRRGLSAV-- 504
            SN R+Q LE ++ L +   G  Q      Q G    +E  + + +M+   +     +  
Sbjct: 441 QSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEAGEPSLDMLLQAQGSFQELYQ 500

Query: 505 VSQAECREGE 514
           V+Q + R+GE
Sbjct: 501 VAQEQVRQGE 510


>gi|55742734 pleckstrin homology domain containing, family G (with
            RhoGef domain) member 4 isoform 1 [Homo sapiens]
          Length = 1191

 Score =  427 bits (1099), Expect = e-119
 Identities = 235/472 (49%), Positives = 313/472 (66%), Gaps = 35/472 (7%)

Query: 785  SSPSGLHPAEEDGRQQVGSSRLRHIMAEMIATEREYIRCLGYVIDNYFPEMERMDLPQGL 844
            +SP+   P   D R     +RL+ ++AEM+ATEREY+R L Y ++NYFPE++R D+PQGL
Sbjct: 715  ASPTVPPPGSSDPRSL---NRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGL 771

Query: 845  RGKHHVIFGNLEKLHDFHQQHFLRELERCQHCPLAVGRSFLRHEEQFGMYVIYSKNKPQS 904
            RG+   +FGNLEKL DFH   FLRELE C   P  V  +FLRH  QFGMY +YSKNKP+S
Sbjct: 772  RGQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRS 831

Query: 905  DALLSSHGNAFFKDKQRELGDKMDLASYLLRPVQRVAKYALLLQDLLKEASCGLAQGQEL 964
            DAL+SS+G+ FFKDKQ+ LGD +DLASYLL+P+QR+ KYALLLQ+L +  +CG    QEL
Sbjct: 832  DALMSSYGHTFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELAR--ACG-GPTQEL 888

Query: 965  GELRAAEVVVCFQLRHGNDLLAMDAIRGCDVNLKEQGQLRCRDEFIVCCGRKKYLRHVFL 1024
              LR A+ +V FQLRHGNDLLAMDAI+GCDVNLKEQGQL  +DEF+V  GR K +R +FL
Sbjct: 889  SALREAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFL 948

Query: 1025 FEDLILFSKTQKVEGSHDVYLYKQSFKTAEIGMTENVGDSGLRFEIWFRRRRKSQDTYIL 1084
            FE+L+LFSK +      D + YK+SFK A++G+TE  G+S LRFEIWF RRRK++DT++L
Sbjct: 949  FEELLLFSKPRHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWF-RRRKARDTFVL 1007

Query: 1085 QASSAEVKSAWTDVIGRILWRQALKSRELRIQEMASMGIGNQPFMDVKPRDRTPDCAVIS 1144
            QASS  +K AWT  I  +LWRQA+ ++E+R+ EM SMG+GN+ F D+ P +         
Sbjct: 1008 QASSLAIKQAWTADISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEE-------- 1059

Query: 1145 DRAPKCAVMSDRVPDSIVKGTESQMRGSTAVSSSDHAAPFKRPHSTISDSSTSSSSSQSS 1204
                    ++DR  + ++K  E + R S AV+  DH + +      +  S++      S 
Sbjct: 1060 -------AINDRTVNYVLKCREVRSRASIAVAPFDHDSLY------LGASNSLPGDPASC 1106

Query: 1205 SILGSLGLLVSSSPAHPGLWSPAHSPWSSDIRACVEEDEPEPELETGTQAAV 1256
            S+LGSL L +   PA  GL  P +  +        EE   E E E G Q ++
Sbjct: 1107 SVLGSLNLHLYRDPALLGLRCPLYPSFP-------EEAALEAEAELGGQPSL 1151



 Score =  173 bits (438), Expect = 1e-42
 Identities = 153/490 (31%), Positives = 223/490 (45%), Gaps = 45/490 (9%)

Query: 38  ASGTQEETSGPRGDPQQTPSLEKERHTPSRTGPGAAGRTLPRRSRSWERAPRSSRGAQAA 97
           A  TQ+E      + Q +P   K +  P+    G A R     S      P  S G ++ 
Sbjct: 53  AGATQDE------ELQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPS-GVESL 105

Query: 98  ACHTSHHSAGSRPGGHLGGQAVGTPNCVPVEGPGCTKEEDVLASSACVSTDGGSLHCHNP 157
            C  S H +       L      TP    V  PG ++      S   + +D        P
Sbjct: 106 LCPMSSHLS-------LAQGESDTPGVGLVGDPGPSRAMPSGLSPGALDSD--------P 150

Query: 158 SGPSDVPARQPHPEQEGWPPGTGDFPSQVPKQV-----LDVSQELLQSGVVTLPGTRDRH 212
            G  D P  +     E  P G+G     +PK        D+  ELL SG+ TLPGTRD  
Sbjct: 151 VGLGD-PLSEISKLLEAAPSGSG-----LPKPADCLLAQDLCWELLASGMATLPGTRDVQ 204

Query: 213 GRAVVQVRTRSLLWTREHSSCAELTRLLLYFHSIPRKEVRDLGLVVLVDARRSPAAPAVS 272
           GRAV+ +   S  W +   S  EL RLLLY  SIPR EV+ LGL VLVDAR    + ++ 
Sbjct: 205 GRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALGLTVLVDARICAPSSSLF 264

Query: 273 QALSGLQNNTSPIIHSILLLVDKESAFRPDKDAIIQCEVVSSLKAVHKFVDSCQLTADLD 332
             LS LQ      ++ +LL+    S    +  + +Q E + S +++   + +  L   L 
Sbjct: 265 SGLSQLQEAAPGAVYQVLLV---GSTLLKEVPSGLQLEQLPS-QSLLTHIPTAGLPTSLG 320

Query: 333 GSFPYSHGDWICFRQRLEHFAANCEEAIIFLQNSFCSLNTHRTPRTAQEVAELIDQHETM 392
           G  PY H  W+ FR+RLE    NC+ A   LQ +  S+     P    EV +L+ Q E +
Sbjct: 321 GGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKAVPQPMEPGEVGQLLQQTEVL 380

Query: 393 MKLVLEDPLLVSLRLEGGTVLARLRR---EELGTEDSRDTLEAATSLYDRVDEEVHRLVL 449
           M+ VL+ P L  L+ +GG  L  L++   E   + D R  ++ A  LYDRVD  +H+L L
Sbjct: 381 MQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTAMDKADELYDRVDGLLHQLTL 440

Query: 450 TSNNRLQQLEHLRELASLLEGNDQQSC---QKGLQLAKENPQRTEEMVQDFRRGLSAV-- 504
            SN R+Q LE ++ L +   G  Q      Q G    +E  + + +M+   +     +  
Sbjct: 441 QSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEAGEPSLDMLLQAQGSFQELYQ 500

Query: 505 VSQAECREGE 514
           V+Q + R+GE
Sbjct: 501 VAQEQVRQGE 510


>gi|50843837 hypothetical protein LOC55701 [Homo sapiens]
          Length = 1519

 Score =  378 bits (970), Expect = e-104
 Identities = 352/1164 (30%), Positives = 532/1164 (45%), Gaps = 146/1164 (12%)

Query: 64   TPSRTGPG------AAGR-TLPRRSRSWERAPRSSRGA--QAAACHTSHHSAGSRPGGHL 114
            TP RTG G      AAGR  L R   S   +P     A  Q A  +    S    P  HL
Sbjct: 371  TPRRTGKGNRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALGNLPSPSEHKLPECHL 430

Query: 115  GGQAV---GTPNCVPVEGPGCTKEEDVLASSACVSTDGGS----------LHCHNPSGPS 161
              +     G P   P E     ++E  L S AC  T+ G+          L     +GP 
Sbjct: 431  VKEEYEGSGKPESEPKELKTAGEKEPQL-SEACGPTEEGAGERELEGPGLLCMAGHTGPE 489

Query: 162  DVPARQPHPEQEGWPPGTGDFPSQVPKQVL--------DVSQELLQSGVVTLPGTRDRHG 213
               +  P P  E    G GD    +P++ L        DV+ +L+ SG + L G  D+ G
Sbjct: 490  GPLSDTPTPPLETVQEGKGD---NIPEEALAVSVSDHPDVAWDLMASGFLILTGGVDQSG 546

Query: 214  RAVVQVRTRSLLWTREHSSCAELTRLLLYFHSIPRKEVRDLGLVVLVDARRSPAAP-AVS 272
            RA++ + T          S   L   L Y HS+ R +++ LGL VL+D R++P  P A+ 
Sbjct: 547  RALLTI-TPPCPPEEPPPSRDTLNTTLHYLHSLLRPDLQTLGLSVLLDLRQAPPLPPALI 605

Query: 273  QALSGLQNNTSP-IIHSILLLVDKESAFRPDKDAIIQCEVVSSLKAVHKFVDSCQLTADL 331
             ALS LQ++  P ++  +L+L+  +    P +    Q   V S   + +     +L  +L
Sbjct: 606  PALSQLQDSGDPPLVQRLLILIHDDL---PTELCGFQGAEVLSENDLKRVAKPEELQWEL 662

Query: 332  DGSFPYSHGDWICFRQRLEHFAANCEEAIIFLQNSFCSLNTHRTPRTAQEVAELIDQHET 391
             G    S   W+   Q +      C+  +  ++ +   L     P    E  E +   + 
Sbjct: 663  GGHRDPSPSHWVEIHQEVVRLCRLCQGVLGSVRQAIEELEGAAEP----EEEEAVGMPKP 718

Query: 392  MMKLVLEDPLLVSLRLEGGTVLARLRREELGTEDSRDTLEAATSLYDRVDEEVHRLVLTS 451
            + K VL DP L +L+ +GG +L RLR     T  S+   +   +LY  VDE +H+LV  S
Sbjct: 719  LQK-VLADPRLTALQRDGGAILMRLR----STPSSKLEGQGPATLYQEVDEAIHQLVRLS 773

Query: 452  NNRLQQLEHLRELASLLEGNDQQSCQKGLQLAK-ENPQRTEEMVQDFR---RGLSAVVSQ 507
            N  +QQ E  + L  L +     S     QLA    P  T   +Q+     R  SA V +
Sbjct: 774  NLHVQQQEQRQCLRRLQQVLQWLSGPGEEQLASFAMPGDTLSALQETELRFRAFSAEVQE 833

Query: 508  --AECREG-ELARWTRSSELCETVSSWMGPLDPEACPSSPVAECLRSCHQ---EATSVAA 561
              A+ RE   L     S ++ +     +  ++     +  +    +  H+   E  +  A
Sbjct: 834  RLAQAREALALEENATSQKVLDIFEQRLEQVESGLHRALRLQRFFQQAHEWVDEGFARLA 893

Query: 562  EAFPGAGVAVLKPHALGKPWASQQDLWLQYPQTRLRLEE--ALSEAAPDPSLPPLAQSPP 619
             A PG   AVL   AL +        + +     L L    AL E     +     +   
Sbjct: 894  GAGPGRE-AVLAALALRRAPEPSAGTFQEMRALALDLGSPAALREWGRCQARCQELERRI 952

Query: 620  KHERAQEAMRRHQKPPSFPSTDSGGGAWEPAQPLSGLPGRALLCGQDGETLRPGLCALWD 679
            +    +EA  R  +        SGG  W P  P                   P L +L  
Sbjct: 953  QQHVGEEASPRGYRRRRADGASSGGAQWGPRSP------------------SPSLSSL-- 992

Query: 680  PLSLLRGLPGAGATTAHLEDSSACSSEPTQTLASRPRKHPQKKMIKKTQSFEIPQPDSGP 739
               LL   PG     +H      CS  P                    + +E   P+  P
Sbjct: 993  ---LLPSSPGPRPAPSH------CSLAPCG------------------EDYEEEGPELAP 1025

Query: 740  RDSCQPDHTSVFSKGLEVTSTVATEKKLPLWQHARSPPVTQSRSLSSPSGLHPAEEDGRQ 799
                +P   +V  +GLEVTST   ++     +H     + ++R    P G+     + ++
Sbjct: 1026 EAEGRPPR-AVLIRGLEVTSTEVVDRTCSPREHVL---LGRARGPDGPWGVGTPRMERKR 1081

Query: 800  QVGSSRLRHIMAEMIATEREYIRCLGYVIDNYFPEMERMDLPQGLRGKHHVIFGNLEKLH 859
             + + +   +++E+IA E++Y+  L   +    PE     L   LRG         E+L 
Sbjct: 1082 SISAQQ--RLVSELIACEQDYVATLSEPVPPPGPE-----LTPELRGTWAAALSARERLR 1134

Query: 860  DFHQQHFLRELERCQHCPLAVGRSFLRHEEQFGMYVIYSKNKPQSDALLSSHGNAFFKDK 919
             FH+ HFLREL+ C   PL +G  FLRH +QF +Y  Y K++ + +  L++         
Sbjct: 1135 SFHRTHFLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLENGLAALSP--LSKG 1192

Query: 920  QRELGDKMDLASYLLRPVQRVAKYALLLQDLLKEASCGLAQGQELGELRAAEVVVCFQLR 979
              E G  +  A  L +P++++ +Y  LL++LL+EA   L+   E   L AA  ++  Q  
Sbjct: 1193 SMEAGPYLPRA--LQQPLEQLTRYGRLLEELLREAGPELSS--ECRALGAAVQLLREQEA 1248

Query: 980  HGNDLLAMDAIRGCDVNLKEQGQLRCRDEFIVCCGRKKYLRHVFLFEDLILFSKTQKVEG 1039
             G DLLA++A+RGC+++LKEQGQL  RD F V CGRKK LRHVFLFE L+LFSK +  EG
Sbjct: 1249 RGRDLLAVEAVRGCEIDLKEQGQLLHRDPFTVICGRKKCLRHVFLFEHLLLFSKLKGPEG 1308

Query: 1040 SHDVYLYKQSFKTAEIGMTENVGDSGLRFEIWFRRRRKSQDTYILQASSAEVKSAWTDVI 1099
              ++++YKQ+FKTA++G+TEN+GDSGL FE+WFRRRR +++ Y LQA+S E+K  WT  I
Sbjct: 1309 GSEMFVYKQAFKTADMGLTENIGDSGLCFELWFRRRR-AREAYTLQATSPEIKLKWTSSI 1367

Query: 1100 GRILWRQALKSRELRIQEMASMGIGNQPFMDVKPRDRTPDCAVISDRAPKCAVMSDRVPD 1159
             ++LWRQA  ++ELR+Q+M SMGIGN+PF+D+K                    + +R   
Sbjct: 1368 AQLLWRQAAHNKELRVQQMVSMGIGNKPFLDIK-------------------ALGERTLS 1408

Query: 1160 SIVKGTESQMRGSTAVSSSDHAAP 1183
            +++ G  ++ R S AVSS +HA P
Sbjct: 1409 ALLTGRAARTRASVAVSSFEHAGP 1432



 Score = 37.7 bits (86), Expect = 0.070
 Identities = 41/157 (26%), Positives = 53/157 (33%), Gaps = 26/157 (16%)

Query: 32  LGTGAVASGTQEETSGPRG-----------------DPQQTPSLEKERHTPSRTGPGAAG 74
           LGT +   G      GP G                 D + +P L + R  P+R G G  G
Sbjct: 222 LGTRSPGDGHNAPVEGPEGEYVELLEVTLPVRGSPTDAEGSPGLSRVRTVPTRKGAGGKG 281

Query: 75  RTLPRRSRSW-ERAPRSSRGAQAAACHTSHHSAGSRPGGHLGGQAVGTPNCVPVEGPGCT 133
           R   RR R+W  +     RG   A       S G+ P    G +AV     + V  P   
Sbjct: 282 R--HRRHRAWMHQKGLGPRGQDGARPPGEGSSTGASPESPPGAEAVPEAAVLEVSEPPAE 339

Query: 134 KEEDVLASSACV----STDGGSLHCHNPSGPSDVPAR 166
              +  AS +C        GG        GP   P R
Sbjct: 340 AVGE--ASGSCPLRPGELRGGGGGGQGAEGPPGTPRR 374


>gi|45439359 triple functional domain (PTPRF interacting) [Homo
            sapiens]
          Length = 3097

 Score =  204 bits (518), Expect = 6e-52
 Identities = 167/574 (29%), Positives = 270/574 (47%), Gaps = 53/574 (9%)

Query: 553  HQEATSVAA-EAFPGAGVAVLKPHALG-------KPWASQQDLWLQYPQTRLRLEEALSE 604
            H+++ SV++ +A P A VA L+PH +G       K   +    WL  P  RL      S 
Sbjct: 1733 HKDSLSVSSNDASPPASVASLQPHMIGAQSSPGPKRPGNTLRKWLTSPVRRL------SS 1786

Query: 605  AAPDPSLPPLAQSPPKHERAQEAMRRHQKPPSFPSTDSGGGAWEPAQPLSGLPGRALLCG 664
               D  +  LA    KH++++E  +         S DS   A  P        GR     
Sbjct: 1787 GKADGHVKKLAH---KHKKSREVRKSADAGSQKDSDDS---AATPQDETVEERGR----- 1835

Query: 665  QDGETLRPGLCALWDPLSLLRGLPGAGATTAHLEDSSACSSEPTQTLASRPRKHPQKKMI 724
               E L  G  +     S   G+   G      E + A    P   +       P  +  
Sbjct: 1836 --NEGLSSGTLSK----SSSSGMQSCGEEEGE-EGADAVPLPPPMAIQQHSLLQPDSQDD 1888

Query: 725  KKTQSFEIPQPDSGPRDSCQPDHTSVFSKGLE-VTSTVATEKK---LPLWQHARSPPVTQ 780
            K +    +      P  S  P    + S   E V S +A E +   L + Q   S P   
Sbjct: 1889 KASSRLLVR-----PTSSETPSAAELVSAIEELVKSKMALEDRPSSLLVDQGDSSSPSFN 1943

Query: 781  SRSLSSPSGLHPAEEDGRQQVGSSRLRH-IMAEMIATEREYIRCLGYVIDNYFPEMERMD 839
                S  S   P +E   ++  S + RH ++ E++ TER+Y+R LGYV++ Y   M+   
Sbjct: 1944 PSDNSLLSSSSPIDEMEERKSSSLKRRHYVLQELVETERDYVRDLGYVVEGYMALMKEDG 2003

Query: 840  LPQGLRGKHHVIFGNLEKLHDFHQQHFLRELERCQHCPLAVGRSFLRHEEQFGMYVIYSK 899
            +P  ++GK  ++FGN+ +++D+H+  FL ELE+C   P  +G  F++HE +  MY+ Y +
Sbjct: 2004 VPDDMKGKDKIVFGNIHQIYDWHRDFFLGELEKCLEDPEKLGSLFVKHERRLHMYIAYCQ 2063

Query: 900  NKPQSDALLSSHGNAFFKDKQRELGDKMDLASYLLRPVQRVAKYALLLQDLLKEASCGLA 959
            NKP+S+ ++S + + FF+D ++ LG ++ L   L++PVQR+ KY LLL+D LK +     
Sbjct: 2064 NKPKSEHIVSEYIDTFFEDLKQRLGHRLQLTDLLIKPVQRIMKYQLLLKDFLKYSK---K 2120

Query: 960  QGQELGELRAAEVVVCFQLRHGNDLLAMDAIRGCDVNLKEQGQLRCRDEFIVCCGRKKYL 1019
               +  EL  A  V+C   R  ND++ +  ++G D  +  QG+L  +D F+V       L
Sbjct: 2121 ASLDTSELERAVEVMCIVPRRCNDMMNVGRLQGFDGKIVAQGKLLLQDTFLVTDQDAGLL 2180

Query: 1020 -----RHVFLFEDLILFSK--TQKVEGSHDVYLYKQSFKTAEIGMTENVGDSGLRFEIWF 1072
                 R +FLFE +++FS+   +K   S   +L+K S K + + + ENV +   +F +  
Sbjct: 2181 PRCRERRIFLFEQIVIFSEPLDKKKGFSMPGFLFKNSIKVSCLCLEENVENDPCKFAL-T 2239

Query: 1073 RRRRKSQDTYILQASSAEVKSAWTDVIGRILWRQ 1106
             R     +T+IL +SS  V+  W   I +IL  Q
Sbjct: 2240 SRTGDVVETFILHSSSPSVRQTWIHEINQILENQ 2273



 Score =  192 bits (488), Expect = 2e-48
 Identities = 113/324 (34%), Positives = 176/324 (54%), Gaps = 14/324 (4%)

Query: 791  HPAEEDGRQQVGSSRLRHIMAEMIATEREYIRCLGYVIDNYFPEMER--MDLPQGLRGKH 848
            H   E+ R+   + R   IMAE+I TE+ Y+R L   +D Y  EM     ++P G+  K 
Sbjct: 1280 HELNEEKRKS--ARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKE 1337

Query: 849  HVIFGNLEKLHDFHQQHFLRELERCQHCPLAVGRSFLRHEEQFGMYVIYSKNKPQSDALL 908
             +IFGN++++++FH   FL+ELE+ +  P  VG  F+   ++F MYV Y KNKP S  L+
Sbjct: 1338 LIIFGNMQEIYEFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLI 1397

Query: 909  SSHGNAFFKDKQRELGDKMDLASYLLRPVQRVAKYALLLQDLLKEASCGLAQGQELGELR 968
              H  ++F + Q+  G    ++SYL++PVQR+ KY LLL++LL     G       GE++
Sbjct: 1398 LEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEG------KGEIK 1451

Query: 969  AAEVVVCFQLRHGNDLLAMDAIRGCDVNLKEQGQLRCRDEFIV----CCGRKKYLRHVFL 1024
                V+    +  ND + +  + G D N++ QG+L  ++ F V       RK   RH+FL
Sbjct: 1452 DGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFL 1511

Query: 1025 FEDLILFSKTQKVEGSHDVYLYKQSFKTAEIGMTENVGDSGLRFEIWFRRRRKSQDTYIL 1084
            FE  ++FSK  K       YLYK    T+E+G+TE+V     +F +W  R   S +  +L
Sbjct: 1512 FEMSLVFSKEVKDSSGRSKYLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVL 1571

Query: 1085 QASSAEVKSAWTDVIGRILWRQAL 1108
            +ASS E K  W   I  ++  + +
Sbjct: 1572 KASSIENKQDWIKHIREVIQERTI 1595



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 71/281 (25%), Positives = 126/281 (44%), Gaps = 27/281 (9%)

Query: 197 LLQSGVVTLPGTRDRHGRAVVQVRTRSLLWTREHSSCAELTRLLLYFHSIPRKEVRDLGL 256
           +L+  V  L G RD+ G  ++    RS     +     +L RL+ Y   IP +EV   G 
Sbjct: 68  ILKEKVAYLSGGRDKRGGPILTFPARS---NHDRIRQEDLRRLISYLACIPSEEVCKRGF 124

Query: 257 VVLVDARRSPAAPAVSQALSGLQNNTSPIIHSILLLVDKESAFRPDKDAIIQCEV----- 311
            V+VD R S    ++   L  LQ +    IH + L++  ++ ++  +      +      
Sbjct: 125 TVIVDMRGSKW-DSIKPLLKILQESFPCCIH-VALIIKPDNFWQKQRTNFGSSKFEFETN 182

Query: 312 VSSLKAVHKFVDSCQLTADLDGSFPYSHGDWICFRQRLEHFAANCEEAIIFLQNSFCSLN 371
           + SL+ + K VD  QLT + DG   Y+H +WI  R   E + +N    +  L+     L 
Sbjct: 183 MVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILA 242

Query: 372 THRTPRTAQEVAELIDQHETMMKLVLEDPLLVSLRLEGGTVLARLRREE--------LGT 423
               P+  +    +I++H  + K V++ P +  L LEG  +L R++  E         G 
Sbjct: 243 KKELPQDLEGARNMIEEHSQLKKKVIKAP-IEDLDLEGQKLLQRIQSSESFPKKNSGSGN 301

Query: 424 EDSRDTLEAATSLYDRVDEEVHRLVLTSNNRLQQLEHLREL 464
            D ++ L   +++ DR+         ++   L Q+ H+R+L
Sbjct: 302 ADLQNLLPKVSTMLDRLH--------STRQHLHQMWHVRKL 334


>gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]
          Length = 2986

 Score =  199 bits (507), Expect = 1e-50
 Identities = 117/334 (35%), Positives = 178/334 (53%), Gaps = 14/334 (4%)

Query: 776  PPVTQSRSLSSPSGLHPAEEDGRQQVGSSRLRHIMAEMIATEREYIRCLGYVIDNYFPEM 835
            P     R +      H   E+ R+   + +   IMAE++ TE+ Y+R L   ++ Y  EM
Sbjct: 1254 PASLSDREVKLRDANHEVNEEKRKS--ARKKEFIMAELLQTEKAYVRDLHECLETYLWEM 1311

Query: 836  ER--MDLPQGLRGKHHVIFGNLEKLHDFHQQHFLRELERCQHCPLAVGRSFLRHEEQFGM 893
                 ++P G+  K H+IFGN+++++DFH   FL+ELE+ +  P  VG  F+   ++F M
Sbjct: 1312 TSGVEEIPPGILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQM 1371

Query: 894  YVIYSKNKPQSDALLSSHGNAFFKDKQRELGDKMDLASYLLRPVQRVAKYALLLQDLLKE 953
            YV Y KNKP S+ L+  H   FF + Q+  G    ++SYL++PVQR+ KY LLL++LL  
Sbjct: 1372 YVTYCKNKPDSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTC 1431

Query: 954  ASCGLAQGQELGELRAAEVVVCFQLRHGNDLLAMDAIRGCDVNLKEQGQLRCRDEFIV-- 1011
               G       GEL+    V+    +  ND + +  + G D NL  QG+L  +D F V  
Sbjct: 1432 CEEG------KGELKDGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWD 1485

Query: 1012 --CCGRKKYLRHVFLFEDLILFSKTQKVEGSHDVYLYKQSFKTAEIGMTENVGDSGLRFE 1069
                 RK   RH+FLFE  ++FSK  K    H  Y+YK    T+E+G+TE+V     +F 
Sbjct: 1486 PKSLIRKGRERHLFLFEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFA 1545

Query: 1070 IWFRRRRKSQDTYILQASSAEVKSAWTDVIGRIL 1103
            +W  R   S +  +L+AS+ E K  W   I  ++
Sbjct: 1546 LWSGRTPSSDNKTVLKASNIETKQEWIKNIREVI 1579



 Score =  181 bits (458), Expect = 5e-45
 Identities = 93/338 (27%), Positives = 195/338 (57%), Gaps = 13/338 (3%)

Query: 774  RSPPVTQSRSLSSPSGLHPAEEDGRQQVGSSRLRHIMAEMIATEREYIRCLGYVIDNYFP 833
            + P    +  ++ P+     EE+ + +    R+  ++ E++ TE++Y++ LG V++ +  
Sbjct: 1899 KDPAGCLNEGMAPPTPPKNPEEEQKAKALRGRM-FVLNELVQTEKDYVKDLGIVVEGFMK 1957

Query: 834  EMERMDLPQGLRGKHHVIFGNLEKLHDFHQQHFLRELERCQHCPLAVGRSFLRHEEQFGM 893
             +E   +P+ +RGK  ++FGN+ +++D+H+  FL ELE+C      + + F++HE +  +
Sbjct: 1958 RIEEKGVPEDMRGKDKIVFGNIHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHI 2017

Query: 894  YVIYSKNKPQSDALLSSHGNAFFKDKQRELGDKMDLASYLLRPVQRVAKYALLLQDLLKE 953
            YV Y +NKP+S+ +++ + +A+F++ ++E+  ++ L+ +L++P+QR+ KY LLL+D L+ 
Sbjct: 2018 YVWYCQNKPRSEYIVAEY-DAYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRY 2076

Query: 954  ASCGLAQGQELGELRAAEVVVCFQLRHGNDLLAMDAIRGCDVNLKEQGQLRCRDEFIVC- 1012
            +      G E  ++  A  ++C   +  ND++ +  ++G +  L  QG+L  +D F V  
Sbjct: 2077 SE---KAGLECSDIEKAVELMCLVPKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIE 2133

Query: 1013 ----CGRKKYLRHVFLFEDLILFSKTQKVEGSHDVYLYKQSFKTAEIGMTENVGDSGLRF 1068
                   +   R VFLFE +++FS+  +       Y++K+S K   + + ENV +   +F
Sbjct: 2134 LDAGMQSRTKERRVFLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKF 2193

Query: 1069 EIWFRRRRKSQDTYILQASSAEVKSAWTDVIGRILWRQ 1106
             +     R++ +  +LQA++A+++ AW   I ++L  Q
Sbjct: 2194 AL---MNRETSERVVLQAANADIQQAWVQDINQVLETQ 2228



 Score = 77.4 bits (189), Expect = 8e-14
 Identities = 73/282 (25%), Positives = 126/282 (44%), Gaps = 29/282 (10%)

Query: 197 LLQSGVVTLPGTRDRHGRAVVQVRTRSLLWTREHSSCAELTRLLLYFHSIPRKEVRDLGL 256
           +L+  V  + G RD+ G  ++    RS     +     +L +L+ Y  S+P ++V   G 
Sbjct: 38  ILKEKVAFVSGGRDKRGGPILTFPARS---NHDRIRQEDLRKLVTYLASVPSEDVCKRGF 94

Query: 257 VVLVDARRSPAAPAVSQALSGLQNNTSPIIHSILLLVDKESAFRPDKDA------IIQCE 310
            V++D R S     +   L  LQ      IH + L++  ++ ++  K        I +  
Sbjct: 95  TVIIDMRGSKW-DLIKPLLKTLQEAFPAEIH-VALIIKPDNFWQKQKTNFGSSKFIFETS 152

Query: 311 VVSSLKAVHKFVDSCQLTADLDGSFPYSHGDWICFRQRLEHFAANCEEAIIFLQNSFCSL 370
           +VS ++ + K VD  QLT + DGS  Y+H +WI  R  LE F  +    +  L++    L
Sbjct: 153 MVS-VEGLTKLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLSRLEDLQEML 211

Query: 371 NTHRTPRTAQEVAELIDQHETMMKLVLEDPLLVSLRLEGGTVLARLRREE--------LG 422
                P   +    LID+H  + K VL+ P +  L  EG  +L  +R  +         G
Sbjct: 212 ARKEFPVDVEGSRRLIDEHTQLKKKVLKAP-VEELDREGQRLLQCIRCSDGFSGRNCIPG 270

Query: 423 TEDSRDTLEAATSLYDRVDEEVHRLVLTSNNRLQQLEHLREL 464
           + D +  +   TSL D++         ++   L Q+ H+R+L
Sbjct: 271 SADFQSLVPKITSLLDKLH--------STRQHLHQMWHVRKL 304


>gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens]
          Length = 1663

 Score =  199 bits (507), Expect = 1e-50
 Identities = 117/334 (35%), Positives = 178/334 (53%), Gaps = 14/334 (4%)

Query: 776  PPVTQSRSLSSPSGLHPAEEDGRQQVGSSRLRHIMAEMIATEREYIRCLGYVIDNYFPEM 835
            P     R +      H   E+ R+   + +   IMAE++ TE+ Y+R L   ++ Y  EM
Sbjct: 1254 PASLSDREVKLRDANHEVNEEKRKS--ARKKEFIMAELLQTEKAYVRDLHECLETYLWEM 1311

Query: 836  ER--MDLPQGLRGKHHVIFGNLEKLHDFHQQHFLRELERCQHCPLAVGRSFLRHEEQFGM 893
                 ++P G+  K H+IFGN+++++DFH   FL+ELE+ +  P  VG  F+   ++F M
Sbjct: 1312 TSGVEEIPPGILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQM 1371

Query: 894  YVIYSKNKPQSDALLSSHGNAFFKDKQRELGDKMDLASYLLRPVQRVAKYALLLQDLLKE 953
            YV Y KNKP S+ L+  H   FF + Q+  G    ++SYL++PVQR+ KY LLL++LL  
Sbjct: 1372 YVTYCKNKPDSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTC 1431

Query: 954  ASCGLAQGQELGELRAAEVVVCFQLRHGNDLLAMDAIRGCDVNLKEQGQLRCRDEFIV-- 1011
               G       GEL+    V+    +  ND + +  + G D NL  QG+L  +D F V  
Sbjct: 1432 CEEG------KGELKDGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWD 1485

Query: 1012 --CCGRKKYLRHVFLFEDLILFSKTQKVEGSHDVYLYKQSFKTAEIGMTENVGDSGLRFE 1069
                 RK   RH+FLFE  ++FSK  K    H  Y+YK    T+E+G+TE+V     +F 
Sbjct: 1486 PKSLIRKGRERHLFLFEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFA 1545

Query: 1070 IWFRRRRKSQDTYILQASSAEVKSAWTDVIGRIL 1103
            +W  R   S +  +L+AS+ E K  W   I  ++
Sbjct: 1546 LWSGRTPSSDNKTVLKASNIETKQEWIKNIREVI 1579



 Score = 77.4 bits (189), Expect = 8e-14
 Identities = 73/282 (25%), Positives = 126/282 (44%), Gaps = 29/282 (10%)

Query: 197 LLQSGVVTLPGTRDRHGRAVVQVRTRSLLWTREHSSCAELTRLLLYFHSIPRKEVRDLGL 256
           +L+  V  + G RD+ G  ++    RS     +     +L +L+ Y  S+P ++V   G 
Sbjct: 38  ILKEKVAFVSGGRDKRGGPILTFPARS---NHDRIRQEDLRKLVTYLASVPSEDVCKRGF 94

Query: 257 VVLVDARRSPAAPAVSQALSGLQNNTSPIIHSILLLVDKESAFRPDKDA------IIQCE 310
            V++D R S     +   L  LQ      IH + L++  ++ ++  K        I +  
Sbjct: 95  TVIIDMRGSKW-DLIKPLLKTLQEAFPAEIH-VALIIKPDNFWQKQKTNFGSSKFIFETS 152

Query: 311 VVSSLKAVHKFVDSCQLTADLDGSFPYSHGDWICFRQRLEHFAANCEEAIIFLQNSFCSL 370
           +VS ++ + K VD  QLT + DGS  Y+H +WI  R  LE F  +    +  L++    L
Sbjct: 153 MVS-VEGLTKLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLSRLEDLQEML 211

Query: 371 NTHRTPRTAQEVAELIDQHETMMKLVLEDPLLVSLRLEGGTVLARLRREE--------LG 422
                P   +    LID+H  + K VL+ P +  L  EG  +L  +R  +         G
Sbjct: 212 ARKEFPVDVEGSRRLIDEHTQLKKKVLKAP-VEELDREGQRLLQCIRCSDGFSGRNCIPG 270

Query: 423 TEDSRDTLEAATSLYDRVDEEVHRLVLTSNNRLQQLEHLREL 464
           + D +  +   TSL D++         ++   L Q+ H+R+L
Sbjct: 271 SADFQSLVPKITSLLDKLH--------STRQHLHQMWHVRKL 304


>gi|150417975 RhoA/RAC/CDC42 exchange factor isoform 1 [Homo sapiens]
          Length = 580

 Score =  197 bits (501), Expect = 5e-50
 Identities = 115/375 (30%), Positives = 204/375 (54%), Gaps = 21/375 (5%)

Query: 792  PAEEDGRQQVGSSRLRHIMAEMIATEREYIRCLGYVIDNYFPEMERMDLPQGLRGKHHVI 851
            P  E+ +++    R  ++++E++ TE+ Y+  LG +++ Y   M    +P+ LRG+  ++
Sbjct: 147  PESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIV 206

Query: 852  FGNLEKLHDFHQQHFLRELERCQHCPLAVGRSFLRHEEQFGMYVIYSKNKPQSDALLSSH 911
            FGN+++++++H+ +FL+EL+RC   P  + + F++HE +  MYV+Y +NKP+S+ ++S  
Sbjct: 207  FGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEF 266

Query: 912  GNAFFKDKQRELGDKMDLASYLLRPVQRVAKYALLLQDLLKEASCGLAQGQELGELRAAE 971
            G+++F++ +++LG ++ L   L++PVQR+ KY LLL+D LK  +     G +  +L  A 
Sbjct: 267  GDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYN---RAGMDTADLEQAV 323

Query: 972  VVVCFQLRHGNDLLAMDAIRGCDVNLKEQGQLRCRDEFIV-------CCGRKKYLRHVFL 1024
             V+CF  +  ND++ +  +RG +  L  QG+L  +D F V           +   R VFL
Sbjct: 324  EVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFL 383

Query: 1025 FEDLILFSKT---QKVEGSHDVYLYKQSFKTAEIGMTENVGDSGLRFEIWFRRRRKSQDT 1081
            FE +I+FS+        G+   Y+YK S K + +G+  N+     RF +  R        
Sbjct: 384  FEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQR 443

Query: 1082 YILQASSAEVKSAWTDVIGRILWRQ-----ALKS---RELRIQEMASMGIGNQPFMDVKP 1133
            Y+LQA+   +  AW   + +IL  Q     AL+S    + R  +  S+G    P +    
Sbjct: 444  YVLQAADPAISQAWIKHVAQILESQRDFLNALQSPIEYQRRESQTNSLGRPRGPGVGSPG 503

Query: 1134 RDRTPDCAVISDRAP 1148
            R R  D A  S   P
Sbjct: 504  RIRLGDQAQGSTHTP 518


>gi|162287076 RhoA/RAC/CDC42 exchange factor isoform 3 [Homo sapiens]
          Length = 619

 Score =  197 bits (501), Expect = 5e-50
 Identities = 115/375 (30%), Positives = 204/375 (54%), Gaps = 21/375 (5%)

Query: 792  PAEEDGRQQVGSSRLRHIMAEMIATEREYIRCLGYVIDNYFPEMERMDLPQGLRGKHHVI 851
            P  E+ +++    R  ++++E++ TE+ Y+  LG +++ Y   M    +P+ LRG+  ++
Sbjct: 186  PESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIV 245

Query: 852  FGNLEKLHDFHQQHFLRELERCQHCPLAVGRSFLRHEEQFGMYVIYSKNKPQSDALLSSH 911
            FGN+++++++H+ +FL+EL+RC   P  + + F++HE +  MYV+Y +NKP+S+ ++S  
Sbjct: 246  FGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEF 305

Query: 912  GNAFFKDKQRELGDKMDLASYLLRPVQRVAKYALLLQDLLKEASCGLAQGQELGELRAAE 971
            G+++F++ +++LG ++ L   L++PVQR+ KY LLL+D LK  +     G +  +L  A 
Sbjct: 306  GDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYN---RAGMDTADLEQAV 362

Query: 972  VVVCFQLRHGNDLLAMDAIRGCDVNLKEQGQLRCRDEFIV-------CCGRKKYLRHVFL 1024
             V+CF  +  ND++ +  +RG +  L  QG+L  +D F V           +   R VFL
Sbjct: 363  EVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFL 422

Query: 1025 FEDLILFSKT---QKVEGSHDVYLYKQSFKTAEIGMTENVGDSGLRFEIWFRRRRKSQDT 1081
            FE +I+FS+        G+   Y+YK S K + +G+  N+     RF +  R        
Sbjct: 423  FEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQR 482

Query: 1082 YILQASSAEVKSAWTDVIGRILWRQ-----ALKS---RELRIQEMASMGIGNQPFMDVKP 1133
            Y+LQA+   +  AW   + +IL  Q     AL+S    + R  +  S+G    P +    
Sbjct: 483  YVLQAADPAISQAWIKHVAQILESQRDFLNALQSPIEYQRRESQTNSLGRPRGPGVGSPG 542

Query: 1134 RDRTPDCAVISDRAP 1148
            R R  D A  S   P
Sbjct: 543  RIRLGDQAQGSTHTP 557


>gi|163644325 MCF.2 cell line derived transforming sequence-like
            isoform a [Homo sapiens]
          Length = 1182

 Score =  195 bits (496), Expect = 2e-49
 Identities = 125/329 (37%), Positives = 183/329 (55%), Gaps = 31/329 (9%)

Query: 807  RHIMAEMIATEREYIRCLGYVIDNYFPEMERMD----LPQGLRGKHHVIFGNLEKLHDFH 862
            RH+M+E++ TER Y+  L  V++ Y  EM+       L  GL  K  V+FGN+E+++ FH
Sbjct: 660  RHVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFH 719

Query: 863  QQHFLRELERCQHCPLAVGRSFLRHEEQFGMYVIYSKNKPQSDALLSSHGNA-FFKDKQR 921
             + FLRELE    CP  VGR FL   E F +Y  Y +NKP+S++L     +  FF++ QR
Sbjct: 720  NRIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQR 779

Query: 922  ELGDKMDLASYLLRPVQRVAKYALLLQDLLK-EASCGLAQGQELGELRAAEVVVCFQLRH 980
            +L  K+ L SYLL+PVQR+ KY LLL+++LK   +C   +G E  +L+ A   +   L+ 
Sbjct: 780  KLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNC---EGAE--DLQEALSSILGILKA 834

Query: 981  GNDLLAMDAIRGCDVNLKEQGQLRCRDEFIVCCGRKK-------------YLRHVFLFED 1027
             ND + + AI G D NL + G+L  +  F V    K+               RH+FL E 
Sbjct: 835  VNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEK 894

Query: 1028 LILFSKTQKVEG----SHDVYLYKQSFKTAEIGMTENVGDSGLRFEIWFRRRRKSQDTYI 1083
             +LF K ++  G        Y YKQS   A +G+TENV     +FEIW+  R   ++ YI
Sbjct: 895  AVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNAR---EEVYI 951

Query: 1084 LQASSAEVKSAWTDVIGRILWRQALKSRE 1112
            +QA + E+K+AW + I ++L  Q    RE
Sbjct: 952  VQAPTPEIKAAWVNEIRKVLTSQLQACRE 980



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 68/261 (26%), Positives = 110/261 (42%), Gaps = 30/261 (11%)

Query: 235 ELTRLLLYFHSIPRKEVRDLGLVVLVDARRSPAAPAVSQALSGLQNNTSPIIHSILLLVD 294
           E   ++ Y  SIP  +   +G ++++D RR       S   S L+   S   +  L+LV 
Sbjct: 137 EFQNVMTYLTSIPSLQDAGIGFILVIDRRRDKWT---SVKASVLRIAASFPANLQLVLVL 193

Query: 295 KESAF-------------RPDKDAIIQCEVVSSLKAVHKFVDSCQLTADLDGSFPYSHGD 341
           + + F             R D    +   ++SS+  +H ++D  QLT DL G+  Y H  
Sbjct: 194 RPTGFFQRTLSDIAFKFNRDDFKMKVPVIMLSSVPDLHGYIDKSQLTEDLGGTLDYCHSR 253

Query: 342 WICFRQRLEHFAANCEEAIIFLQNSFCSLNTHRTPRTAQEVAELIDQHETMMKLVLEDPL 401
           W+C R  +E FA   ++    LQ+    L     P   Q  + ++  H T  K   ++ L
Sbjct: 254 WLCQRTAIESFALMVKQTAQMLQSFGTELAETELPNDVQSTSSVLCAH-TEKKDKAKEDL 312

Query: 402 LVSLRLEGGTVLARLRREELGTEDSRDTLEAATSLYDRVDEEVHRLVLTSNNRLQQLEHL 461
            ++L+ EG +VL  LR  EL  E S  ++       D++D +      T    L QL   
Sbjct: 313 RLALK-EGHSVLESLR--ELQAEGSEPSVN-----QDQLDNQA-----TVQRLLAQLNET 359

Query: 462 RELASLLEGNDQQSCQKGLQL 482
                      QQ  ++ LQL
Sbjct: 360 EAAFDEFWAKHQQKLEQCLQL 380


>gi|163644323 MCF.2 cell line derived transforming sequence-like
            isoform b [Homo sapiens]
          Length = 1129

 Score =  195 bits (496), Expect = 2e-49
 Identities = 125/329 (37%), Positives = 183/329 (55%), Gaps = 31/329 (9%)

Query: 807  RHIMAEMIATEREYIRCLGYVIDNYFPEMERMD----LPQGLRGKHHVIFGNLEKLHDFH 862
            RH+M+E++ TER Y+  L  V++ Y  EM+       L  GL  K  V+FGN+E+++ FH
Sbjct: 607  RHVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFH 666

Query: 863  QQHFLRELERCQHCPLAVGRSFLRHEEQFGMYVIYSKNKPQSDALLSSHGNA-FFKDKQR 921
             + FLRELE    CP  VGR FL   E F +Y  Y +NKP+S++L     +  FF++ QR
Sbjct: 667  NRIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQR 726

Query: 922  ELGDKMDLASYLLRPVQRVAKYALLLQDLLK-EASCGLAQGQELGELRAAEVVVCFQLRH 980
            +L  K+ L SYLL+PVQR+ KY LLL+++LK   +C   +G E  +L+ A   +   L+ 
Sbjct: 727  KLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNC---EGAE--DLQEALSSILGILKA 781

Query: 981  GNDLLAMDAIRGCDVNLKEQGQLRCRDEFIVCCGRKK-------------YLRHVFLFED 1027
             ND + + AI G D NL + G+L  +  F V    K+               RH+FL E 
Sbjct: 782  VNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEK 841

Query: 1028 LILFSKTQKVEG----SHDVYLYKQSFKTAEIGMTENVGDSGLRFEIWFRRRRKSQDTYI 1083
             +LF K ++  G        Y YKQS   A +G+TENV     +FEIW+  R   ++ YI
Sbjct: 842  AVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNAR---EEVYI 898

Query: 1084 LQASSAEVKSAWTDVIGRILWRQALKSRE 1112
            +QA + E+K+AW + I ++L  Q    RE
Sbjct: 899  VQAPTPEIKAAWVNEIRKVLTSQLQACRE 927



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 68/261 (26%), Positives = 110/261 (42%), Gaps = 30/261 (11%)

Query: 235 ELTRLLLYFHSIPRKEVRDLGLVVLVDARRSPAAPAVSQALSGLQNNTSPIIHSILLLVD 294
           E   ++ Y  SIP  +   +G ++++D RR       S   S L+   S   +  L+LV 
Sbjct: 84  EFQNVMTYLTSIPSLQDAGIGFILVIDRRRDKWT---SVKASVLRIAASFPANLQLVLVL 140

Query: 295 KESAF-------------RPDKDAIIQCEVVSSLKAVHKFVDSCQLTADLDGSFPYSHGD 341
           + + F             R D    +   ++SS+  +H ++D  QLT DL G+  Y H  
Sbjct: 141 RPTGFFQRTLSDIAFKFNRDDFKMKVPVIMLSSVPDLHGYIDKSQLTEDLGGTLDYCHSR 200

Query: 342 WICFRQRLEHFAANCEEAIIFLQNSFCSLNTHRTPRTAQEVAELIDQHETMMKLVLEDPL 401
           W+C R  +E FA   ++    LQ+    L     P   Q  + ++  H T  K   ++ L
Sbjct: 201 WLCQRTAIESFALMVKQTAQMLQSFGTELAETELPNDVQSTSSVLCAH-TEKKDKAKEDL 259

Query: 402 LVSLRLEGGTVLARLRREELGTEDSRDTLEAATSLYDRVDEEVHRLVLTSNNRLQQLEHL 461
            ++L+ EG +VL  LR  EL  E S  ++       D++D +      T    L QL   
Sbjct: 260 RLALK-EGHSVLESLR--ELQAEGSEPSVN-----QDQLDNQA-----TVQRLLAQLNET 306

Query: 462 RELASLLEGNDQQSCQKGLQL 482
                      QQ  ++ LQL
Sbjct: 307 EAAFDEFWAKHQQKLEQCLQL 327


>gi|153791628 MCF.2 cell line derived transforming sequence isoform a
            [Homo sapiens]
          Length = 985

 Score =  182 bits (463), Expect = 1e-45
 Identities = 118/321 (36%), Positives = 176/321 (54%), Gaps = 29/321 (9%)

Query: 808  HIMAEMIATEREYIRCLGYVIDNYFPEMERMDL----PQGLRGKHHVIFGNLEKLHDFHQ 863
            H++ E+I TER Y+R L  V+  Y  EM+  ++    P  LR K  ++FGN+ ++++FH 
Sbjct: 558  HVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEFHN 617

Query: 864  QHFLRELERCQHCPLAVGRSFLRHEEQFGMYVIYSKNKPQSDALLSSHGN-AFFKDKQRE 922
              FL  LE C H P  VG  FL  ++ F MY  Y +NKP+S+ +   +   AFF++ QR+
Sbjct: 618  DIFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSECAFFQECQRK 677

Query: 923  LGDKMDLASYLLRPVQRVAKYALLLQDLLKEASCGLAQGQELGELRAAEVVVCFQLRHGN 982
            L  ++ L SYLL+PVQR+ KY LLL++LLK +     +G  L  L+ A   +   L+  N
Sbjct: 678  LKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKD--CEGSAL--LKKALDAMLDLLKSVN 733

Query: 983  DLLAMDAIRGCDVNLKEQGQLRCRDEFIVCCGRKK-------------YLRHVFLFEDLI 1029
            D +   AI G   NL E G++  +  F V  G KK               RH+FL+E  I
Sbjct: 734  DSMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAI 793

Query: 1030 LFSK--TQKVEGS--HDVYLYKQSFKTAEIGMTENVGDSGLRFEIWFRRRRKSQDTYILQ 1085
            +F K   +  EGS  +  Y +K  +K  E+G+TE V     +FEIW+  +   ++ YI+Q
Sbjct: 794  VFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYGEK---EEVYIVQ 850

Query: 1086 ASSAEVKSAWTDVIGRILWRQ 1106
            AS+ +VK  W   I  IL +Q
Sbjct: 851  ASNVDVKMTWLKEIRNILLKQ 871



 Score = 54.7 bits (130), Expect = 6e-07
 Identities = 46/192 (23%), Positives = 84/192 (43%), Gaps = 14/192 (7%)

Query: 236 LTRLLLYFHSIPRKEVRDLGLVVLVDARRSPAAPAVSQALSGLQNNTSPIIHSILLLVDK 295
           + ++L Y  SI R+   D    +++D RR     ++  +L  +  +    +H +L+L   
Sbjct: 35  IAKVLTYLTSIARQNGSDSRFTIILD-RRLDTWSSLKISLQKISASFPGNLHLVLVLRPT 93

Query: 296 ESAFRP---------DKDAIIQCEVV--SSLKAVHKFVDSCQLTADLDGSFPYSHGDWIC 344
               R           +D +++  VV  SS+  +  ++D  QLT +L G+  Y H +WI 
Sbjct: 94  SFLQRTFTDIGFWFSQEDFMLKLPVVMLSSVSDLLTYIDDKQLTPELGGTLQYCHSEWII 153

Query: 345 FRQRLEHFAANCEEAIIFLQNSFCSLNTHRTPRTAQEVAELIDQHETMMKLVLEDPLLVS 404
           FR  +E+FA   +E    LQ+    L     P     + E++        L+  D  + +
Sbjct: 154 FRNAIENFALTVKEMAQMLQSFGTELAETELPDDIPSIEEILAIRAERYHLLKND--ITA 211

Query: 405 LRLEGGTVLARL 416
           +  EG  +L  L
Sbjct: 212 VTKEGKILLTNL 223


>gi|153791325 MCF.2 cell line derived transforming sequence isoform b
            [Homo sapiens]
          Length = 925

 Score =  182 bits (463), Expect = 1e-45
 Identities = 118/321 (36%), Positives = 176/321 (54%), Gaps = 29/321 (9%)

Query: 808  HIMAEMIATEREYIRCLGYVIDNYFPEMERMDL----PQGLRGKHHVIFGNLEKLHDFHQ 863
            H++ E+I TER Y+R L  V+  Y  EM+  ++    P  LR K  ++FGN+ ++++FH 
Sbjct: 498  HVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEFHN 557

Query: 864  QHFLRELERCQHCPLAVGRSFLRHEEQFGMYVIYSKNKPQSDALLSSHGN-AFFKDKQRE 922
              FL  LE C H P  VG  FL  ++ F MY  Y +NKP+S+ +   +   AFF++ QR+
Sbjct: 558  DIFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSECAFFQECQRK 617

Query: 923  LGDKMDLASYLLRPVQRVAKYALLLQDLLKEASCGLAQGQELGELRAAEVVVCFQLRHGN 982
            L  ++ L SYLL+PVQR+ KY LLL++LLK +     +G  L  L+ A   +   L+  N
Sbjct: 618  LKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKD--CEGSAL--LKKALDAMLDLLKSVN 673

Query: 983  DLLAMDAIRGCDVNLKEQGQLRCRDEFIVCCGRKK-------------YLRHVFLFEDLI 1029
            D +   AI G   NL E G++  +  F V  G KK               RH+FL+E  I
Sbjct: 674  DSMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAI 733

Query: 1030 LFSK--TQKVEGS--HDVYLYKQSFKTAEIGMTENVGDSGLRFEIWFRRRRKSQDTYILQ 1085
            +F K   +  EGS  +  Y +K  +K  E+G+TE V     +FEIW+  +   ++ YI+Q
Sbjct: 734  VFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYGEK---EEVYIVQ 790

Query: 1086 ASSAEVKSAWTDVIGRILWRQ 1106
            AS+ +VK  W   I  IL +Q
Sbjct: 791  ASNVDVKMTWLKEIRNILLKQ 811



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 29/106 (27%), Positives = 50/106 (47%), Gaps = 2/106 (1%)

Query: 311 VVSSLKAVHKFVDSCQLTADLDGSFPYSHGDWICFRQRLEHFAANCEEAIIFLQNSFCSL 370
           ++SS+  +  ++D  QLT +L G+  Y H +WI FR  +E+FA   +E    LQ+    L
Sbjct: 60  MLSSVSDLLTYIDDKQLTPELGGTLQYCHSEWIIFRNAIENFALTVKEMAQMLQSFGTEL 119

Query: 371 NTHRTPRTAQEVAELIDQHETMMKLVLEDPLLVSLRLEGGTVLARL 416
                P     + E++        L+  D  + ++  EG  +L  L
Sbjct: 120 AETELPDDIPSIEEILAIRAERYHLLKND--ITAVTKEGKILLTNL 163


>gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens]
          Length = 1289

 Score =  181 bits (458), Expect = 5e-45
 Identities = 93/338 (27%), Positives = 195/338 (57%), Gaps = 13/338 (3%)

Query: 774  RSPPVTQSRSLSSPSGLHPAEEDGRQQVGSSRLRHIMAEMIATEREYIRCLGYVIDNYFP 833
            + P    +  ++ P+     EE+ + +    R+  ++ E++ TE++Y++ LG V++ +  
Sbjct: 202  KDPAGCLNEGMAPPTPPKNPEEEQKAKALRGRM-FVLNELVQTEKDYVKDLGIVVEGFMK 260

Query: 834  EMERMDLPQGLRGKHHVIFGNLEKLHDFHQQHFLRELERCQHCPLAVGRSFLRHEEQFGM 893
             +E   +P+ +RGK  ++FGN+ +++D+H+  FL ELE+C      + + F++HE +  +
Sbjct: 261  RIEEKGVPEDMRGKDKIVFGNIHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHI 320

Query: 894  YVIYSKNKPQSDALLSSHGNAFFKDKQRELGDKMDLASYLLRPVQRVAKYALLLQDLLKE 953
            YV Y +NKP+S+ +++ + +A+F++ ++E+  ++ L+ +L++P+QR+ KY LLL+D L+ 
Sbjct: 321  YVWYCQNKPRSEYIVAEY-DAYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRY 379

Query: 954  ASCGLAQGQELGELRAAEVVVCFQLRHGNDLLAMDAIRGCDVNLKEQGQLRCRDEFIVC- 1012
            +      G E  ++  A  ++C   +  ND++ +  ++G +  L  QG+L  +D F V  
Sbjct: 380  SE---KAGLECSDIEKAVELMCLVPKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIE 436

Query: 1013 ----CGRKKYLRHVFLFEDLILFSKTQKVEGSHDVYLYKQSFKTAEIGMTENVGDSGLRF 1068
                   +   R VFLFE +++FS+  +       Y++K+S K   + + ENV +   +F
Sbjct: 437  LDAGMQSRTKERRVFLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKF 496

Query: 1069 EIWFRRRRKSQDTYILQASSAEVKSAWTDVIGRILWRQ 1106
             +     R++ +  +LQA++A+++ AW   I ++L  Q
Sbjct: 497  AL---MNRETSERVVLQAANADIQQAWVQDINQVLETQ 531


>gi|71274186 hypothetical protein LOC85449 [Homo sapiens]
          Length = 1200

 Score =  179 bits (454), Expect = 1e-44
 Identities = 114/306 (37%), Positives = 163/306 (53%), Gaps = 12/306 (3%)

Query: 157 PSGPSDVPARQPHPEQEGWPPGTGDFPSQVPKQVLDVSQELLQSGVVTLPGTRDRHGRAV 216
           P   +  P R P  E+E  PPG          ++  +  ++ +S +  LPG RDR GR +
Sbjct: 542 PEASAGSPERGPTLEEE--PPGP-------EPRIGALGVKVFRSRIACLPGGRDRAGRPL 592

Query: 217 VQVRTRSLLWTREHSSCAELTRLLLYFHSIPRKEVRDLGLVVLVDARRSPAAPAVSQALS 276
           + V T    W     + +E+T+LL Y  +IPR E +  GL VL+DARR P  P +  AL 
Sbjct: 593 LLVSTTEGAWEAPWCTVSEVTKLLSYLCTIPRPEDKAKGLAVLIDARRQPPQPGLVSALQ 652

Query: 277 GLQNNTSPIIHSILLLVDKESAFRPDKDAIIQCEVVSSLKAVHKFVDSCQLTADLDGSFP 336
             Q      I +IL L +KE+A +      +Q EV++SLKA+   VD  QL A L+G FP
Sbjct: 653 ATQAQVPASIRAILFLGEKEAALQLQTLPDVQVEVLTSLKALSHHVDPSQLPAVLEGPFP 712

Query: 337 YSHGDWICFRQRLEHFAANCEEAIIFLQNSFCSLNTHRTPRTAQEVAELIDQHETMMKLV 396
           Y H +W+ F Q+L+ F A+  +A   LQ S         P   QE    + + + +M+ V
Sbjct: 713 YCHTEWVHFFQKLDPFLADLHQASSLLQASIEEFEKADPPGGMQEATRCLSKSKELMEAV 772

Query: 397 LEDPLLVSLRLEGGTVLARLRREELGTE---DSRDTLEAATSLYDRVDEEVHRLVLTSNN 453
           L DP L+ L+ EGG  LARL+ +    +   D R  L AAT+LY  VDE++H LV  SN+
Sbjct: 773 LRDPGLLGLQREGGATLARLQHDASRLDFSPDVRSHLAAATALYSLVDEQLHVLVTASNS 832

Query: 454 RLQQLE 459
            L +LE
Sbjct: 833 LLGKLE 838


>gi|31742505 Rho family guanine-nucleotide exchange factor [Homo
            sapiens]
          Length = 1114

 Score =  119 bits (297), Expect = 2e-26
 Identities = 124/450 (27%), Positives = 199/450 (44%), Gaps = 64/450 (14%)

Query: 701  SACSSEPTQTLASRPRKHPQKKMIKKTQSFEIPQPDSGP-RDSCQP-DHTSVFSKGLEVT 758
            +A  + P Q +A  P   P K +  KT       P + P R S +P   T + S+G E  
Sbjct: 527  AAKQTRPVQPVAPHPESSP-KWVSSKTSQPSTSVPLARPLRTSEEPYTETELNSRGKEDD 585

Query: 759  STVATEKKLPLWQ--HARSPPVTQSRSLSSPSGLHPAEEDGRQQVGS-SRLRHIMAEMIA 815
             T    K   +++  H R  P                E + + ++G  S  R I+ +++ 
Sbjct: 586  ETKFEVKSEEIFESHHERGNP----------------ELEQQARLGDLSPRRRIIRDLLE 629

Query: 816  TEREYIRCLGYVIDNYFPEMERMDL----PQGLRGKHHVIFGNLEKLHDFHQQHFLRELE 871
            TE  YI+ +  +ID Y   M+ + L    P  L+     +FGN+ +L++FH + FL+ELE
Sbjct: 630  TEEIYIKEIKSIIDGYITPMDFIWLKHLIPDVLQNNKDFLFGNIRELYEFHNRTFLKELE 689

Query: 872  RCQHCPLAVGRSFLRHEEQFGMYVIYSKNKPQSDALLSS-HGNAFFKDKQRELGDKMDLA 930
            +C   P  +   FL+ +E   +Y  Y KN P++ A+       A+F   QR+L   + L 
Sbjct: 690  KCAENPELLAHCFLKRKEDLQIYFKYHKNLPRARAIWQECQDCAYFGVCQRQLDHNLPLF 749

Query: 931  SYLLRPVQRVAKYALLLQDLL-------KEASCG-LAQGQELGELRAAEVVVCFQLRHG- 981
             YL  P QR+ KY +LL+ LL        E   G L    + G  R  +     +L+   
Sbjct: 750  KYLKGPSQRLIKYQMLLKGLLDFESPEDMEIDPGELGGSAKDGPKRTKDSAFSTELQQAL 809

Query: 982  ---NDL-----LAMD--AIRGCDVNLKEQGQLRCRDEFIVCCGRK-KY-----------L 1019
                DL     LA+D  A+  C  ++ + G+L     F V    K +Y            
Sbjct: 810  AVIEDLIKSCELAVDLAAVTECPDDIGKLGKLLLHGPFSVWTIHKDRYKMKDLIRFKPSQ 869

Query: 1020 RHVFLFEDLILFSKTQKVEGSHDV---YLYKQSFKTAEIGMTENVGDSGLRFEIWFRRRR 1076
            R ++LFE  I+F K +   G   +   Y +K++ K   + + +    S  +FEI     R
Sbjct: 870  RQIYLFERGIVFCKIRMEPGDQGLSPHYSFKKTMKLMTLSIRQLGRGSHRKFEI---ASR 926

Query: 1077 KSQDTYILQASSAEVKSAWTDVIGRILWRQ 1106
               + YILQA+S E++  W   I ++L  Q
Sbjct: 927  NGLEKYILQAASKEIRDCWFSEISKLLMEQ 956



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 70/300 (23%), Positives = 127/300 (42%), Gaps = 33/300 (11%)

Query: 187 PKQVLDVSQELLQSGVVTLPGTRDRHGRAVVQVRTRSLLWTREHSSCAELTRLLLYFHSI 246
           P   +++ ++L +   + L G R   G  ++     S     +H    +   ++ Y  SI
Sbjct: 35  PLMAVEIIEQLHRQFAI-LSGGRGEDGAPIITFPEFSGF---KHIPDEDFLNVMTYLTSI 90

Query: 247 PRKEVRDLGLVVLVDARRSPAAPAVSQALSGLQNNTSPIIHSILLLVDKE---------- 296
           P  E   +G +V++D RR   + +V  +L+ +       +  I +L              
Sbjct: 91  PSVEAASIGFIVVIDRRRDKWS-SVKASLTRIAVAFPGNLQLIFILRPSRFIQRTFTDIG 149

Query: 297 -SAFRPDKDAIIQCEVVSSLKAVHKFVDSCQLTADLDGSFPYSHGDWICFRQRLEHFAAN 355
              +R +    +   +V+S+  +H ++D  QLT +L G+  Y HG W+  R  +E+FA  
Sbjct: 150 IKYYRNEFKTKVPIIMVNSVSDLHGYIDKSQLTRELGGTLEYRHGQWVNHRTAIENFALT 209

Query: 356 CEEAIIFLQNSFCSLNTHRTPRTAQEVAELIDQHETMMKLVLEDPLLVSLRLEGGTVLAR 415
            +     LQ     L T   PR+     +L+  H T  +  L+D L + L  +G T+L+ 
Sbjct: 210 LKTTAQMLQTFGSCLATAELPRSMLSTEDLLMSH-TRQRDKLQDELKL-LGKQGTTLLSC 267

Query: 416 LRREELGTEDSR---DTLEAATS---LYDRVDE---------EVHRLVLTSNNRLQQLEH 460
           ++       +S+   + LE  T+   L  ++DE           H L L    +LQ  EH
Sbjct: 268 IQEPATKCPNSKLNLNQLENVTTMERLLVQLDETEKAFSHFWSEHHLKLNQCLQLQHFEH 327


>gi|71274148 pleckstrin homology domain containing, family G (with
            RhoGef domain) member 1 [Homo sapiens]
          Length = 1385

 Score =  101 bits (251), Expect = 5e-21
 Identities = 81/310 (26%), Positives = 148/310 (47%), Gaps = 26/310 (8%)

Query: 809  IMAEMIATEREYIRCLGYVIDNYFPEM-ERMDLPQGLRGKHHVIFGNLEKLHDFHQQHFL 867
            ++ E++ TER Y++ L  ++++Y   + ++  LP G   +   +FGN++ ++ F+ +  L
Sbjct: 117  VVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTE-ERSALFGNIQDIYHFNSE-LL 174

Query: 868  RELERCQHCPLAVGRSFLRHEEQFGMYVIYSKNKPQSDALLSSHGN-----AFFKDKQRE 922
            ++LE C++ P+A+   F+   E+F +Y  Y  N P+S A+L+          FF+++Q  
Sbjct: 175  QDLENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRERQET 234

Query: 923  LGDKMDLASYLLRPVQRVAKYALLLQD----LLKEASCGLAQGQELGELRAAEVVVCFQL 978
            L   + L SYLL+PVQR+ KY LLL +    L K+          +  ++     +    
Sbjct: 235  LKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMK 294

Query: 979  RHGNDLLAMDAIRGCDVN-----LKEQGQLRCRDEFIVCCGRKKYLRHVFLFEDLILFSK 1033
            R     + +  I+    N     L   G+L     F +   R K  R +FLF+ L+L +K
Sbjct: 295  RKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRI--QRAKNERTLFLFDKLLLITK 352

Query: 1034 TQKVEGSHDVYLYKQSFKTAEIGMTENVGDSGLRFEIWFRRRRKSQDTYILQASSAEVKS 1093
             +      D + YK       + + E +    L F ++  +  K Q T  +QA S + K 
Sbjct: 353  KR-----DDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQHT--VQAKSQQDKR 405

Query: 1094 AWTDVIGRIL 1103
             W   + R++
Sbjct: 406  LWVLHLKRLI 415


>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
            exchange factor [Homo sapiens]
          Length = 1386

 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 87/328 (26%), Positives = 144/328 (43%), Gaps = 44/328 (13%)

Query: 804  SRLRHIMAEMIATEREYIRCLGYVIDNYFPEMERMDLPQGLRG----KHHVIFGNLEKLH 859
            SRL  +  E++ TER Y+R L  ++++Y   +    L  G+ G    +   +F N+E ++
Sbjct: 101  SRLERVAREIVETERAYVRDLRSIVEDYLGPL----LDGGVLGLSVEQVGTLFANIEDIY 156

Query: 860  DFHQQHFLRELERCQHCPLAVGRSFLRHEEQFGMYVIYSKNKPQSDALL-----SSHGNA 914
            +F  +  L +LE        +   F++  E F +Y +Y  N P S ALL     S     
Sbjct: 157  EFSSE-LLEDLENSSSAG-GIAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAAL 214

Query: 915  FFKDKQRELGDKMDLASYLLRPVQRVAKYALLLQDLLKEASCGLAQGQELGELRAAEVVV 974
            + +++Q +L   + L S+LL+PVQR+ KY LLLQ+L K  + G   G   G     E +V
Sbjct: 215  WLQERQAQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTG---GREMVEEAIV 271

Query: 975  CF------------QLRHGNDLLAMDAIRG--CDVNLKEQGQLRCRDEFIVCCGRKKYLR 1020
                          +  H   L  +    G      L   G+L     F    G    LR
Sbjct: 272  SMTAVAWYINDMKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAFRGGGGGGPRLR 331

Query: 1021 H----VFLFEDLILFSKTQKVEGSHDVYLYKQSFKTAEIGMTENVGDSGLRFEIWFRRRR 1076
                 +FLF  ++L +K + +E     Y YK       + ++E+  D  L F++      
Sbjct: 332  GGERLLFLFSRMLLVAKRRGLE-----YTYKGHIFCCNLSVSESPRDP-LGFKVSDLTIP 385

Query: 1077 KSQDTYILQASSAEVKSAWTDVIGRILW 1104
            K +  ++LQA + E K  W   + R+ +
Sbjct: 386  KHR--HLLQAKNQEEKRLWIHCLQRLFF 411


>gi|58331253 obscurin, cytoskeletal calmodulin and titin-interacting
            RhoGEF isoform a [Homo sapiens]
          Length = 6620

 Score = 78.6 bits (192), Expect = 4e-14
 Identities = 78/299 (26%), Positives = 126/299 (42%), Gaps = 55/299 (18%)

Query: 861  FHQQHFLRELERCQHCPLAV--------------GR--------------------SFLR 886
            F Q H L+ LERC H P+AV              GR                     F++
Sbjct: 5714 FLQSHHLQHLERCPHVPIAVAGQKAVIFRNVRDIGRFHSSFLQELQQCDTDDDVAMCFIK 5773

Query: 887  HEEQFGMYVIYSKNKPQSDALLSSHGNAFFKDKQRE----LGDKMD-----LASYLLRPV 937
            ++  F  Y+ +   + Q+++++ S     F  K  E     GD        L  YL +PV
Sbjct: 5774 NQAAFEQYLEFLVGRVQAESVVVSTAIQEFYKKYAEEALLAGDPSQPPPPPLQHYLEQPV 5833

Query: 938  QRVAKYALLLQDLLKEASCGLAQGQELGELRAAEVVVCFQLRHGNDLLAMDAIRGCDVNL 997
            +RV +Y  LL++L++  +      Q    L  A  VV    +   + L +  +      L
Sbjct: 5834 ERVQRYQALLKELIRNKA---RNRQNCALLEQAYAVVSALPQRAENKLHVSLMENYPGTL 5890

Query: 998  KEQGQLRCRDEFIVCCGR-------KKYLRHVFLFEDLILFSKTQKVEGSHDV-YLYKQS 1049
            +  G+   +  FIV  G        K + RHVFLF + ++  K ++   +  V Y+++  
Sbjct: 5891 QALGEPIRQGHFIVWEGAPGARMPWKGHNRHVFLFRNHLVICKPRRDSRTDTVSYVFRNM 5950

Query: 1050 FKTAEIGMTENVGDSGLRFEIWFRRRRKSQDTYILQASSAEVKSAWTDVIGRILWRQAL 1108
             K + I + + V      FE+W + R  S   Y+LQA +A +KS+W   I  I  R AL
Sbjct: 5951 MKLSSIDLNDQVEGDDRAFEVW-QEREDSVRKYLLQARTAIIKSSWVKEICGIQQRLAL 6008



 Score = 32.3 bits (72), Expect = 3.0
 Identities = 40/168 (23%), Positives = 62/168 (36%), Gaps = 17/168 (10%)

Query: 595  RLRLEEALSEAAPDPSLPPLAQSPPKHERAQEAMRRHQKPPSFPSTDSGGGAWEPAQPLS 654
            ++ L  A  + AP PSLPP A          EA+ R ++    P+ DS          +S
Sbjct: 4710 QVALSPASVDEAPQPSLPPEAAQEGDLHLLWEALARKRRMSREPTLDS----------IS 4759

Query: 655  GLP---GRALLCGQDGETLRPGLCALWDPLSLLRGLPGAGATTAHLEDSSACSSEPTQTL 711
             LP   GR+    Q+ E + P L   +     L     A  +    +D S   +    T 
Sbjct: 4760 ELPEEDGRSQRLPQEAEEVAPDLSEGYSTADELARTGDADLSHTSSDDESRAGTPSLVTY 4819

Query: 712  ---ASRPRKHPQKKMIKKTQSFEI-PQPDSGPRDSCQPDHTSVFSKGL 755
               A RP   P    +    +  + PQ    P  + +P    + +K L
Sbjct: 4820 LKKAGRPGTSPLASKVGAPAAPSVKPQQQQEPLAAVRPPLGDLSTKDL 4867


>gi|148833506 obscurin, cytoskeletal calmodulin and titin-interacting
            RhoGEF isoform b [Homo sapiens]
          Length = 7968

 Score = 78.6 bits (192), Expect = 4e-14
 Identities = 78/299 (26%), Positives = 126/299 (42%), Gaps = 55/299 (18%)

Query: 861  FHQQHFLRELERCQHCPLAV--------------GR--------------------SFLR 886
            F Q H L+ LERC H P+AV              GR                     F++
Sbjct: 5714 FLQSHHLQHLERCPHVPIAVAGQKAVIFRNVRDIGRFHSSFLQELQQCDTDDDVAMCFIK 5773

Query: 887  HEEQFGMYVIYSKNKPQSDALLSSHGNAFFKDKQRE----LGDKMD-----LASYLLRPV 937
            ++  F  Y+ +   + Q+++++ S     F  K  E     GD        L  YL +PV
Sbjct: 5774 NQAAFEQYLEFLVGRVQAESVVVSTAIQEFYKKYAEEALLAGDPSQPPPPPLQHYLEQPV 5833

Query: 938  QRVAKYALLLQDLLKEASCGLAQGQELGELRAAEVVVCFQLRHGNDLLAMDAIRGCDVNL 997
            +RV +Y  LL++L++  +      Q    L  A  VV    +   + L +  +      L
Sbjct: 5834 ERVQRYQALLKELIRNKA---RNRQNCALLEQAYAVVSALPQRAENKLHVSLMENYPGTL 5890

Query: 998  KEQGQLRCRDEFIVCCGR-------KKYLRHVFLFEDLILFSKTQKVEGSHDV-YLYKQS 1049
            +  G+   +  FIV  G        K + RHVFLF + ++  K ++   +  V Y+++  
Sbjct: 5891 QALGEPIRQGHFIVWEGAPGARMPWKGHNRHVFLFRNHLVICKPRRDSRTDTVSYVFRNM 5950

Query: 1050 FKTAEIGMTENVGDSGLRFEIWFRRRRKSQDTYILQASSAEVKSAWTDVIGRILWRQAL 1108
             K + I + + V      FE+W + R  S   Y+LQA +A +KS+W   I  I  R AL
Sbjct: 5951 MKLSSIDLNDQVEGDDRAFEVW-QEREDSVRKYLLQARTAIIKSSWVKEICGIQQRLAL 6008



 Score = 32.3 bits (72), Expect = 3.0
 Identities = 40/168 (23%), Positives = 62/168 (36%), Gaps = 17/168 (10%)

Query: 595  RLRLEEALSEAAPDPSLPPLAQSPPKHERAQEAMRRHQKPPSFPSTDSGGGAWEPAQPLS 654
            ++ L  A  + AP PSLPP A          EA+ R ++    P+ DS          +S
Sbjct: 4710 QVALSPASVDEAPQPSLPPEAAQEGDLHLLWEALARKRRMSREPTLDS----------IS 4759

Query: 655  GLP---GRALLCGQDGETLRPGLCALWDPLSLLRGLPGAGATTAHLEDSSACSSEPTQTL 711
             LP   GR+    Q+ E + P L   +     L     A  +    +D S   +    T 
Sbjct: 4760 ELPEEDGRSQRLPQEAEEVAPDLSEGYSTADELARTGDADLSHTSSDDESRAGTPSLVTY 4819

Query: 712  ---ASRPRKHPQKKMIKKTQSFEI-PQPDSGPRDSCQPDHTSVFSKGL 755
               A RP   P    +    +  + PQ    P  + +P    + +K L
Sbjct: 4820 LKKAGRPGTSPLASKVGAPAAPSVKPQQQQEPLAAVRPPLGDLSTKDL 4867


>gi|55749621 pleckstrin homology domain containing, family G, member 3
            [Homo sapiens]
          Length = 1163

 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 74/253 (29%), Positives = 115/253 (45%), Gaps = 29/253 (11%)

Query: 867  LRELERCQHCPLAVGRSFLRHEEQFGMYVIYSKNKPQSDALLSS-----HGNAFFKDKQR 921
            +RE+   +   +   RS +  +E F +Y  Y  N P S A L+          FF+D+Q 
Sbjct: 98   VREIVETERMYVQDLRSIVESQE-FDIYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQE 156

Query: 922  ELGDKMDLASYLLRPVQRVAKYALLLQDLLKEASCGLAQGQELGELRAAEVVVCF----- 976
             L   + L SYLL+PVQR+ KY LLLQ++ K        G E+ E  A + + C      
Sbjct: 157  LLQHSLPLGSYLLKPVQRILKYHLLLQEIAKHFD-EEEDGFEVVE-DAIDTMTCVAWYIN 214

Query: 977  -QLRHGNDLLAMDAIRGCDVN-----LKEQGQLRCRDEFIVCCGRKKYLRHVFLFEDLIL 1030
               R     + +  I+   +N     L   G+L     F V   R +  R  FLF+  +L
Sbjct: 215  DMKRRHEHAVRLQEIQSLLINWKGPDLTTYGELVLEGTFRV--HRVRNERTFFLFDKTLL 272

Query: 1031 FSKTQKVEGSHDVYLYKQSFKTAEIGMTENVGDSGLRFEIWFRRRRKSQDTYILQASSAE 1090
             +K +   G H  ++YK +   + + + E+  DS L F +   +  K Q  Y +QA + E
Sbjct: 273  ITKKR---GDH--FVYKGNIPCSSLMLIESTRDS-LCFTVTHYKHSKQQ--YSIQAKTVE 324

Query: 1091 VKSAWTDVIGRIL 1103
             K  WT  I R++
Sbjct: 325  EKRNWTHHIKRLI 337


>gi|23308553 spermatogenesis associated 13 [Homo sapiens]
          Length = 652

 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 96/382 (25%), Positives = 156/382 (40%), Gaps = 62/382 (16%)

Query: 784  LSSPSGLHPAEEDGRQQVGSSRLRH----------IMAEMIATEREYIRCLGYVIDNYFP 833
            LS  S   P+EE   ++   SR RH          ++ E++ TER YI+ L  + + Y  
Sbjct: 210  LSENSSSTPSEEQD-EEASQSRHRHCENKQQMRTNVIREIMDTERVYIKHLRDICEGYIR 268

Query: 834  EMERMDLPQGLRGKHHVIFGNLEKLHDFHQQHFLRELERCQHCP----LAVGRSFLRHEE 889
            +  R         +   IFGN+E ++ F Q+ FL++LE+  +        +G  FL+++E
Sbjct: 269  QC-RKHTGMFTVAQLATIFGNIEDIYKF-QRKFLKDLEKQYNKEEPHLSEIGSCFLQNQE 326

Query: 890  QFGMYVIYSKNKP----QSDALLSSHGNAFFKDKQRELGDKMDLA--SYLLRPVQRVAKY 943
             F +Y  Y  N P    +   L+       F +  R L   +D+A   +LL PVQ++ KY
Sbjct: 327  GFAIYSEYCNNHPGACLELANLMKQGKYRHFFEACRLLQQMIDIAIDGFLLTPVQKICKY 386

Query: 944  ALLLQDLLKEASCGLAQGQELGE-------LRAAEVVVCFQLRHGNDLLAMDAIRGCDVN 996
             L L +LLK  +      QE G+         A + V C        L ++D I    V+
Sbjct: 387  PLQLAELLKYTT------QEHGDYSNIKAAYEAMKNVACLINERKRKLESIDKIARWQVS 440

Query: 997  LK--EQGQLRCRDEFIVCCGR--------KKYLRHVFLFEDLILFSKTQKVEGSHDVYLY 1046
            +   E   +  R   ++  G         K   R  FLF+  ++  K   +    D+  Y
Sbjct: 441  IVGWEGLDILDRSSELIHSGELTKITKQGKSQQRTFFLFDHQLVSCKKDLLR--RDMLYY 498

Query: 1047 KQSFKTAEIGMTE----NVGDSGLRFEIWFRR-RRKSQDTYILQASSAEVKSAWTDVIGR 1101
            K      E+ + +       D  L  +  F+   R + + Y+  A   E K+ W      
Sbjct: 499  KGRLDMDEMELVDLGDGRDKDCNLSVKNAFKLVSRTTDEVYLFCAKKQEDKARWL----- 553

Query: 1102 ILWRQALKSRELRIQEMASMGI 1123
                QA      R+QE   MG+
Sbjct: 554  ----QACADERRRVQEDKEMGM 571


>gi|39930351 dynamin binding protein [Homo sapiens]
          Length = 1577

 Score = 67.8 bits (164), Expect = 6e-11
 Identities = 60/189 (31%), Positives = 94/189 (49%), Gaps = 27/189 (14%)

Query: 779 TQSRSLSSPSGLHPAEEDGRQQVGSSRLRHIMAEMIATEREYIRCLGYVIDNYFPEMERM 838
           +QS SL +PSG   AE   ++ +   +   ++ E++ TER+YIR L   I+     M++ 
Sbjct: 760 SQSSSLVAPSGSVSAENPEQRML--EKRAKVIEELLQTERDYIRDLEMCIERIMVPMQQA 817

Query: 839 DLPQ-GLRGKHHVIFGNLEKLHDFHQQHFLRELERCQHCPLAVGRSFLRHEEQF-GMYVI 896
            +P     G    +FGN++ +    +Q  L  LE       AVG  FL H ++  G Y I
Sbjct: 818 QVPNIDFEG----LFGNMQMVIKVSKQ-LLAALEISD----AVGPVFLGHRDELEGTYKI 868

Query: 897 YSKNKPQSDALLSSHGN------------AFFKDKQRELG--DKMDLASYLLRPVQRVAK 942
           Y +N  ++ ALL  +              A  K    E G  + ++L S+L++PVQRV +
Sbjct: 869 YCQNHDEAIALLEIYEKDEKIQKHLQDSLADLKSLYNEWGCTNYINLGSFLIKPVQRVMR 928

Query: 943 YALLLQDLL 951
           Y LLL +LL
Sbjct: 929 YPLLLMELL 937


>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [Homo
            sapiens]
          Length = 690

 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 102/436 (23%), Positives = 179/436 (41%), Gaps = 42/436 (9%)

Query: 786  SPSGLHPAEEDGRQQVGSSRLR---HIMAEMIATEREYIRCLGYVIDNYFPEMER---MD 839
            +P   +   EDG  +  SS+ +   +++ E+++TER+YI+ L  + + Y  +  +   M 
Sbjct: 262  APLAGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADMF 321

Query: 840  LPQGLRGKHHVIFGNLEKLHDFHQQHFLRELE----RCQHCPLAVGRSFLRHEEQFGMYV 895
              + LR     IFGN+E ++   Q+ F++ LE    R +     +G  FL H+  F +Y 
Sbjct: 322  SEEQLR----TIFGNIEDIYRC-QKAFVKALEQRFNRERPHLSELGACFLEHQADFQIYS 376

Query: 896  IYSKNKPQSDALLSSHGN----AFFKDKQRELGDKMDLA--SYLLRPVQRVAKYALLLQD 949
             Y  N P +   LS         +F +  R L   +D++   +LL PVQ++ KY L L +
Sbjct: 377  EYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAE 436

Query: 950  LLKEASCGLAQGQEL-GELRAAEVVVCFQLRHGNDLLAMDAIRGCDVNLK--EQGQLRCR 1006
            LLK         +++   L A + V          L  +D I     +++  E   L  R
Sbjct: 437  LLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVR 496

Query: 1007 DEFIVCCGR---------KKYLRHVFLFEDLILFSKTQKVEGSHDVYLYKQSFKTAEIGM 1057
               ++  G          K   R  FLF+  +++ K   +      Y  +      E+  
Sbjct: 497  SSELIYSGELTRVTQPQAKSQQRMFFLFDHQLIYCKKDLLRRDVLYYKGRLDMDGLEVVD 556

Query: 1058 TENVGDSGLRFEI--WFR-RRRKSQDTYILQASSAEVKSAWTDVIGR----ILWRQALKS 1110
             E+  D  L   I   FR  R  + D+++L     E K  W     R    +   Q    
Sbjct: 557  LEDGKDRDLHVSIKNAFRLHRGATGDSHLLCTRKPEQKQRWLKAFAREREQVQLDQETGF 616

Query: 1111 RELRIQEMASMGIGNQPFMDVKPRDRTPDCAVISDRAPKCAVMSDRVPDSIVKGTESQMR 1170
                +Q   +M   ++  +  KP+     C +   + P  A+ S+R    ++   E + +
Sbjct: 617  SITELQRKQAMLNASKQQVTGKPKAVGRPCYLTRQKHP--ALPSNRPQQQVLVLAEPRRK 674

Query: 1171 GSTAVSSSDHAAPFKR 1186
             ST   S    APF++
Sbjct: 675  PSTFWHSISRLAPFRK 690


>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
            exchange factor 1 [Homo sapiens]
          Length = 1659

 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 90/366 (24%), Positives = 148/366 (40%), Gaps = 57/366 (15%)

Query: 785  SSPSGLHPAEEDGRQQVGSSRLRH-IMAEMIATEREYIRCLGYVIDNYFPEMERM---DL 840
            S P     A E  RQ     RLR  ++ E++ TER+Y+  L ++   +   + +     +
Sbjct: 32   SGPGPCAAARESERQL----RLRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSV 87

Query: 841  PQGLRGKH-HVIFGNLEKLHDFHQQHFLRELERCQH----CPLAVGRSFLRHEEQFGMYV 895
             +GL  ++  V+F N+E + + H+  FL  LE C H        +G  FL+ +++F +Y 
Sbjct: 88   EKGLTEENVKVLFSNIEDILEVHKD-FLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYE 146

Query: 896  IYSKNKPQSDALLSSHGN-----AFFKDKQRELGDK---MDLASYLLRPVQRVAKYALLL 947
             Y  N  ++  LL          AF        G K   + L  YLL P+QR+ KY LLL
Sbjct: 147  EYCSNHEKALRLLVELNKIPTVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLL 206

Query: 948  QDLLKEASCGLAQGQELGELRAAEVVVCFQL----RHGNDLLAMDAIRGC-----DVNLK 998
            ++L K           +     A   VC  +    R    L A++ ++         NL 
Sbjct: 207  KELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLT 266

Query: 999  E-QGQLRCRDEFIVCCGRKKYLRHVFLFEDLILFSK--------------TQKVEGSHDV 1043
            +   QL  +   +         R  FLF++L+++ K              T+ + GS  +
Sbjct: 267  DICTQLLLQGTLLKISAGNIQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGS--L 324

Query: 1044 YLYKQSFKTAEIGMTENVGDSGLRFEI--------WFRRRRKSQDTYILQASSAEVKSAW 1095
            Y+++    T E+   ENV D    +          W          ++  A +AE K  W
Sbjct: 325  YIFRGRINT-EVMEVENVEDGTADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKW 383

Query: 1096 TDVIGR 1101
             D I R
Sbjct: 384  LDAIIR 389


>gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]
          Length = 979

 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 77/348 (22%), Positives = 134/348 (38%), Gaps = 53/348 (15%)

Query: 809  IMAEMIATEREYIRCLGYVIDNYFPEMERMDLPQGLRGKHH----VIFGNLEKLHDFHQQ 864
            +++E+  TER+Y+  L +++  +   M +    +  +        ++F N+E +   H++
Sbjct: 27   VLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKE 86

Query: 865  HFLRELERCQH----CPLAVGRSFLRHEEQFGMYVIYSKNKPQSDALLSSHGN-----AF 915
             FL+ +E C H        VG  FL  +++F +Y  Y  N  ++  LL           F
Sbjct: 87   -FLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTF 145

Query: 916  FKDKQRELGDK---MDLASYLLRPVQRVAKYALLLQDLLKEASCGLAQGQELGELRAAEV 972
              +     G K   + L  YL+ P+QR+ KY L+L++LLK      +    + E   A  
Sbjct: 146  LLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQAMK 205

Query: 973  VVCFQLRHGNDLLA-----------MDAIRGCDVNLKEQGQLRCRDEFIVCCGRKKYLRH 1021
             VC  +      +            ++   G ++       L C     +  G  +  R 
Sbjct: 206  AVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKISSGNIQE-RV 264

Query: 1022 VFLFEDLILFS-------KTQKVEGSHDVYLYKQSFKTAEIGMTENVGDSGLRFEI---- 1070
             FLF++L+++        K  K       YL++    T E+   ENV D    F      
Sbjct: 265  FFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINT-EVMEVENVDDGTADFHSSGHI 323

Query: 1071 ----WFRRRRKSQDTYILQASSAEVKSAWTDVIGRILWRQALKSRELR 1114
                W          ++  A + E K  W + I        LK RE R
Sbjct: 324  VVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAI--------LKERERR 363


>gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]
          Length = 1606

 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 77/348 (22%), Positives = 134/348 (38%), Gaps = 53/348 (15%)

Query: 809  IMAEMIATEREYIRCLGYVIDNYFPEMERMDLPQGLRGKHH----VIFGNLEKLHDFHQQ 864
            +++E+  TER+Y+  L +++  +   M +    +  +        ++F N+E +   H++
Sbjct: 27   VLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKE 86

Query: 865  HFLRELERCQH----CPLAVGRSFLRHEEQFGMYVIYSKNKPQSDALLSSHGN-----AF 915
             FL+ +E C H        VG  FL  +++F +Y  Y  N  ++  LL           F
Sbjct: 87   -FLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTF 145

Query: 916  FKDKQRELGDK---MDLASYLLRPVQRVAKYALLLQDLLKEASCGLAQGQELGELRAAEV 972
              +     G K   + L  YL+ P+QR+ KY L+L++LLK      +    + E   A  
Sbjct: 146  LLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQAMK 205

Query: 973  VVCFQLRHGNDLLA-----------MDAIRGCDVNLKEQGQLRCRDEFIVCCGRKKYLRH 1021
             VC  +      +            ++   G ++       L C     +  G  +  R 
Sbjct: 206  AVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKISSGNIQE-RV 264

Query: 1022 VFLFEDLILFS-------KTQKVEGSHDVYLYKQSFKTAEIGMTENVGDSGLRFEI---- 1070
             FLF++L+++        K  K       YL++    T E+   ENV D    F      
Sbjct: 265  FFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINT-EVMEVENVDDGTADFHSSGHI 323

Query: 1071 ----WFRRRRKSQDTYILQASSAEVKSAWTDVIGRILWRQALKSRELR 1114
                W          ++  A + E K  W + I        LK RE R
Sbjct: 324  VVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAI--------LKERERR 363


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.131    0.393 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,612,461
Number of Sequences: 37866
Number of extensions: 2864465
Number of successful extensions: 14900
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 66
Number of HSP's successfully gapped in prelim test: 261
Number of HSP's that attempted gapping in prelim test: 13916
Number of HSP's gapped (non-prelim): 1032
length of query: 1271
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1157
effective length of database: 13,930,794
effective search space: 16117928658
effective search space used: 16117928658
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.