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Search of human proteins with 146229327
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|146229327 arylsulfatase A isoform b [Homo sapiens]
(423 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|146229331 arylsulfatase A isoform a precursor [Homo sapiens] 887 0.0
gi|146229329 arylsulfatase A isoform a precursor [Homo sapiens] 887 0.0
gi|146229327 arylsulfatase A isoform b [Homo sapiens] 887 0.0
gi|146229324 arylsulfatase A isoform a precursor [Homo sapiens] 887 0.0
gi|6005990 arylsulfatase A isoform a precursor [Homo sapiens] 887 0.0
gi|45430057 Arylsulfatase G [Homo sapiens] 197 1e-50
gi|4503899 galactosamine (N-acetyl)-6-sulfate sulfatase precurso... 181 1e-45
gi|157266309 arylsulfatase E precursor [Homo sapiens] 153 2e-37
gi|53831991 steryl-sulfatase precursor [Homo sapiens] 147 2e-35
gi|31742482 arylsulfatase F precursor [Homo sapiens] 145 9e-35
gi|58743319 arylsulfatase family, member H [Homo sapiens] 122 5e-28
gi|71852584 arylsulfatase D isoform a precursor [Homo sapiens] 112 5e-25
gi|59797060 arylsulfatase family, member I [Homo sapiens] 93 4e-19
gi|38569405 arylsulfatase B isoform 1 precursor [Homo sapiens] 84 2e-16
gi|109389362 arylsulfatase J [Homo sapiens] 83 4e-16
gi|38569407 arylsulfatase B isoform 2 precursor [Homo sapiens] 82 1e-15
gi|39930577 arylsulfatase K [Homo sapiens] 66 7e-11
gi|4506919 N-sulfoglucosamine sulfohydrolase precursor [Homo sap... 54 2e-07
gi|4504061 glucosamine (N-acetyl)-6-sulfatase precursor [Homo sa... 53 5e-07
gi|71852586 arylsulfatase D isoform b precursor [Homo sapiens] 49 7e-06
gi|240255483 sulfatase 2 isoform a precursor [Homo sapiens] 48 1e-05
gi|240255478 sulfatase 2 isoform b precursor [Homo sapiens] 48 1e-05
gi|29789100 sulfatase 2 isoform a precursor [Homo sapiens] 48 1e-05
gi|189571643 sulfatase 1 [Homo sapiens] 46 6e-05
gi|189571641 sulfatase 1 [Homo sapiens] 46 6e-05
gi|189571638 sulfatase 1 [Homo sapiens] 46 6e-05
gi|189571636 sulfatase 1 [Homo sapiens] 46 6e-05
gi|4557659 iduronate-2-sulfatase isoform a precursor [Homo sapiens] 39 0.009
gi|39752687 hypothetical protein LOC375791 [Homo sapiens] 39 0.009
gi|195947389 autotaxin isoform 3 preproprotein [Homo sapiens] 36 0.075
>gi|146229331 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 887 bits (2293), Expect = 0.0
Identities = 423/423 (100%), Positives = 423/423 (100%)
Query: 1 MGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRF 60
MGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRF
Sbjct: 85 MGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRF 144
Query: 61 LGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEARYMAF 120
LGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEARYMAF
Sbjct: 145 LGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEARYMAF 204
Query: 121 AHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTA 180
AHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTA
Sbjct: 205 AHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTA 264
Query: 181 IGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAP 240
IGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAP
Sbjct: 265 IGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAP 324
Query: 241 GVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVR 300
GVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVR
Sbjct: 325 GVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVR 384
Query: 301 GVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPLLYDLSKDPGENYNLLGG 360
GVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPLLYDLSKDPGENYNLLGG
Sbjct: 385 GVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPLLYDLSKDPGENYNLLGG 444
Query: 361 VAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQICCHPGCTPRPACCHCPD 420
VAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQICCHPGCTPRPACCHCPD
Sbjct: 445 VAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQICCHPGCTPRPACCHCPD 504
Query: 421 PHA 423
PHA
Sbjct: 505 PHA 507
>gi|146229329 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 887 bits (2293), Expect = 0.0
Identities = 423/423 (100%), Positives = 423/423 (100%)
Query: 1 MGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRF 60
MGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRF
Sbjct: 85 MGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRF 144
Query: 61 LGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEARYMAF 120
LGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEARYMAF
Sbjct: 145 LGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEARYMAF 204
Query: 121 AHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTA 180
AHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTA
Sbjct: 205 AHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTA 264
Query: 181 IGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAP 240
IGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAP
Sbjct: 265 IGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAP 324
Query: 241 GVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVR 300
GVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVR
Sbjct: 325 GVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVR 384
Query: 301 GVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPLLYDLSKDPGENYNLLGG 360
GVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPLLYDLSKDPGENYNLLGG
Sbjct: 385 GVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPLLYDLSKDPGENYNLLGG 444
Query: 361 VAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQICCHPGCTPRPACCHCPD 420
VAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQICCHPGCTPRPACCHCPD
Sbjct: 445 VAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQICCHPGCTPRPACCHCPD 504
Query: 421 PHA 423
PHA
Sbjct: 505 PHA 507
>gi|146229327 arylsulfatase A isoform b [Homo sapiens]
Length = 423
Score = 887 bits (2293), Expect = 0.0
Identities = 423/423 (100%), Positives = 423/423 (100%)
Query: 1 MGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRF 60
MGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRF
Sbjct: 1 MGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRF 60
Query: 61 LGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEARYMAF 120
LGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEARYMAF
Sbjct: 61 LGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEARYMAF 120
Query: 121 AHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTA 180
AHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTA
Sbjct: 121 AHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTA 180
Query: 181 IGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAP 240
IGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAP
Sbjct: 181 IGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAP 240
Query: 241 GVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVR 300
GVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVR
Sbjct: 241 GVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVR 300
Query: 301 GVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPLLYDLSKDPGENYNLLGG 360
GVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPLLYDLSKDPGENYNLLGG
Sbjct: 301 GVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPLLYDLSKDPGENYNLLGG 360
Query: 361 VAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQICCHPGCTPRPACCHCPD 420
VAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQICCHPGCTPRPACCHCPD
Sbjct: 361 VAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQICCHPGCTPRPACCHCPD 420
Query: 421 PHA 423
PHA
Sbjct: 421 PHA 423
>gi|146229324 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 887 bits (2293), Expect = 0.0
Identities = 423/423 (100%), Positives = 423/423 (100%)
Query: 1 MGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRF 60
MGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRF
Sbjct: 85 MGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRF 144
Query: 61 LGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEARYMAF 120
LGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEARYMAF
Sbjct: 145 LGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEARYMAF 204
Query: 121 AHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTA 180
AHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTA
Sbjct: 205 AHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTA 264
Query: 181 IGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAP 240
IGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAP
Sbjct: 265 IGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAP 324
Query: 241 GVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVR 300
GVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVR
Sbjct: 325 GVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVR 384
Query: 301 GVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPLLYDLSKDPGENYNLLGG 360
GVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPLLYDLSKDPGENYNLLGG
Sbjct: 385 GVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPLLYDLSKDPGENYNLLGG 444
Query: 361 VAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQICCHPGCTPRPACCHCPD 420
VAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQICCHPGCTPRPACCHCPD
Sbjct: 445 VAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQICCHPGCTPRPACCHCPD 504
Query: 421 PHA 423
PHA
Sbjct: 505 PHA 507
>gi|6005990 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 887 bits (2293), Expect = 0.0
Identities = 423/423 (100%), Positives = 423/423 (100%)
Query: 1 MGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRF 60
MGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRF
Sbjct: 85 MGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRF 144
Query: 61 LGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEARYMAF 120
LGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEARYMAF
Sbjct: 145 LGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEARYMAF 204
Query: 121 AHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTA 180
AHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTA
Sbjct: 205 AHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTA 264
Query: 181 IGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAP 240
IGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAP
Sbjct: 265 IGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAP 324
Query: 241 GVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVR 300
GVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVR
Sbjct: 325 GVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVR 384
Query: 301 GVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPLLYDLSKDPGENYNLLGG 360
GVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPLLYDLSKDPGENYNLLGG
Sbjct: 385 GVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPLLYDLSKDPGENYNLLGG 444
Query: 361 VAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQICCHPGCTPRPACCHCPD 420
VAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQICCHPGCTPRPACCHCPD
Sbjct: 445 VAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQICCHPGCTPRPACCHCPD 504
Query: 421 PHA 423
PHA
Sbjct: 505 PHA 507
>gi|45430057 Arylsulfatase G [Homo sapiens]
Length = 525
Score = 197 bits (501), Expect = 1e-50
Identities = 151/425 (35%), Positives = 201/425 (47%), Gaps = 46/425 (10%)
Query: 11 SSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQG 70
+S GGLPL E T+AEVL GY+TG+ GKWHLG G++ P +GF + GIPYSHD G
Sbjct: 109 TSVGGLPLNETTLAEVLQQAGYVTGIIGKWHLG--HHGSYHPNFRGFDYYFGIPYSHDMG 166
Query: 71 PCQNLTCFP----PATPCDGGCDQGL-------VPIPLLANLSVEAQPPWLPGLEARYMA 119
C + + PA P G + L V +PL NL++ QP L L +Y
Sbjct: 167 -CTDTPGYNHPPCPACPQGDGPSRNLQRDCYTDVALPLYENLNIVEQPVNLSSLAQKYAE 225
Query: 120 FAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMT 179
A + A RPF LY A H H P Q A GR +G L E+D+ VG +
Sbjct: 226 KATQFIQRASTSGRPFLLYVALAHMHVPLPVTQLPAAPRGRSLYGAGLWEMDSLVGQIKD 285
Query: 180 AIGDLGLLEETLVIFTADNGPETMRMSRGGCSG------LLRCG----KGTTYEGGVREP 229
+ D + E T + FT DNGP + G G R G K TT+EGG R P
Sbjct: 286 KV-DHTVKENTFLWFTGDNGPWAQKCELAGSVGPFTGFWQTRQGGSPAKQTTWEGGHRVP 344
Query: 230 ALAFWPGHIAPGVTH-ELASSLDLLPTLAALAGAPLP-NVTLDGFDLSPLLLGTGKSPRQ 287
ALA+WPG + VT L S LD+ PT+ ALA A LP DG D+S +L G + P
Sbjct: 345 ALAYWPGRVPVNVTSTALLSVLDIFPTVVALAQASLPQGRRFDGVDVSEVLFGRSQ-PGH 403
Query: 288 SLFFYPS--YPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPLLY 345
+ F+P+ E + VR +YKA + T G+ D + P H+ PL++
Sbjct: 404 RVLFHPNSGAAGEFGALQTVRLERYKAFYITGGARACDGSTGPELQ-------HKFPLIF 456
Query: 346 DLSKDPGENYNLLGGVA---GATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQ 402
+L D E L G A PEV + L + L S +DP++
Sbjct: 457 NLEDDTAEAVPLERGGAEYQAVLPEVRKVLADV------LQDIANDNISSADYTQDPSVT 510
Query: 403 ICCHP 407
CC+P
Sbjct: 511 PCCNP 515
>gi|4503899 galactosamine (N-acetyl)-6-sulfate sulfatase precursor
[Homo sapiens]
Length = 522
Score = 181 bits (459), Expect = 1e-45
Identities = 144/432 (33%), Positives = 211/432 (48%), Gaps = 59/432 (13%)
Query: 14 GGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQ 73
GG+P E + E+L GY++ + GKWHLG P+ F P GF + G P H GP
Sbjct: 115 GGIPDSEQLLPELLKKAGYVSKIVGKWHLGHRPQ--FHPLKHGFDEWFGSPNCHF-GPYD 171
Query: 74 NLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEAR----YMAFAHDLMADAQ 129
N P P + + E P L EA Y+ A D + Q
Sbjct: 172 NKA--RPNIPVYRDWE--------MVGRYYEEFPINLKTGEANLTQIYLQEALDFIK-RQ 220
Query: 130 RQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEE 189
+ PFFLY+A TH P ++ + F S RG +GD++ E+D ++G ++ + DL + +
Sbjct: 221 ARHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYGDAVREIDDSIGKILELLQDLHVADN 280
Query: 190 TLVIFTADNGPETMRM-SRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAPG-VTHELA 247
T V FT+DNG + +GG +G CGK TT+EGG+REPALA+WPGH+ G V+H+L
Sbjct: 281 TFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLG 340
Query: 248 SSLDLLPTLAALAG-APLPNVTLDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVRG--VFA 304
S +DL T ALAG P + +DG +L P LL G+ + +F+Y RG + A
Sbjct: 341 SIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLL-QGRLMDRPIFYY-------RGDTLMA 392
Query: 305 VRTGKYKAHFFT-QGSAHSDTTADPACHAS--SSLTAH------EPPLLYDLSKDPGENY 355
G++KAHF+T S + C S +T H + PL++ L +DPGE +
Sbjct: 393 ATLGQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVTTHNLEDHTKLPLIFHLGRDPGERF 452
Query: 356 NLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQIC-------CHPG 408
L + A+ E +AL ++ + Q A+ P+Q P L +C PG
Sbjct: 453 PL----SFASAEYQEALSRITSVVQQHQEALV--PAQ------PQLNVCNWAVMNWAPPG 500
Query: 409 CTPRPACCHCPD 420
C C P+
Sbjct: 501 CEKLGKCLTPPE 512
>gi|157266309 arylsulfatase E precursor [Homo sapiens]
Length = 589
Score = 153 bits (387), Expect = 2e-37
Identities = 135/461 (29%), Positives = 200/461 (43%), Gaps = 71/461 (15%)
Query: 14 GGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGA----FLPPHQGFHRFLGIPYSHDQ 69
GGLP E T A++L +GY TG+ GKWHLG+ E A P H GF F G+P+S
Sbjct: 120 GGLPTNETTFAKILKEKGYATGLIGKWHLGLNCESASDHCHHPLHHGFDHFYGMPFSL-M 178
Query: 70 GPCQNLTCFPPATPCDGGCD-----QGLVPIPLLANLSVEAQP-PWLPG----------L 113
G C + + LV + L+A P W+P L
Sbjct: 179 GDCARWELSEKRVNLEQKLNFLFQVLALVALTLVAGKLTHLIPVSWMPVIWSALSAVLLL 238
Query: 114 EARYMAFAHDLMADA-------------------------------QRQDRPFFLYYASH 142
+ Y A + AD + + PF L+ +
Sbjct: 239 ASSYFVGALIVHADCFLMRNHTITEQPMCFQRTTPLILQEVASFLKRNKHGPFLLFVSFL 298
Query: 143 HTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNG--- 199
H H P + ++F +S G +GD++ E+D VG ++ + GL TL+ FT+D+G
Sbjct: 299 HVHIPLITMENFLGKSLHGLYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSL 358
Query: 200 -PETMRMSRGGCSGLLRCGKGT-TYEGGVREPALAFWPGHIAPG-VTHELASSLDLLPTL 256
+ GG +G+ + GKG +EGG+R P + WPG + G V E S +D+ PT+
Sbjct: 359 ENQLGNTQYGGWNGIYKGGKGMGGWEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTV 418
Query: 257 AALAGAPLP-NVTLDGFDLSPLLLGTGK-SPRQSLFFY-PSYPDEVRGVFAVRTGKYKAH 313
LAG +P + +DG DL PLLLGT + S + L Y + R R +K H
Sbjct: 419 VRLAGGEVPQDRVIDGQDLLPLLLGTAQHSDHEFLMHYCERFLHAARWHQRDRGTMWKVH 478
Query: 314 FFT---QGSAHSDTTADPACHA-SSSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEVL 369
F T Q C + H+PPLL+DLS+DP E + L + P
Sbjct: 479 FVTPVFQPEGAGACYGRKVCPCFGEKVVHHDPPLLFDLSRDPSETHIL---TPASEPVFY 535
Query: 370 QALKQLQLLKAQLDAAVTFGPSQVARGED---PALQICCHP 407
Q ++++Q + ++ P Q+ R + P LQ CC P
Sbjct: 536 QVMERVQQAVWEHQRTLSPVPLQLDRLGNIWRPWLQPCCGP 576
>gi|53831991 steryl-sulfatase precursor [Homo sapiens]
Length = 583
Score = 147 bits (370), Expect = 2e-35
Identities = 107/325 (32%), Positives = 159/325 (48%), Gaps = 21/325 (6%)
Query: 97 LLANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAE 156
++ N + QP L R A + + + PF L + H H FS + FA
Sbjct: 244 MMRNYEIIQQPMSYDNLTQRLTVEAAQFIQ--RNTETPFLLVLSYLHVHTALFSSKDFAG 301
Query: 157 RSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMS-----RGGCS 211
+S G +GD++ E+D +VG ++ + +L L +TL+ FT+D G +S GG +
Sbjct: 302 KSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSN 361
Query: 212 GLLRCGKGTTYEGGVREPALAFWPGHIAPG-VTHELASSLDLLPTLAALAGAPLP-NVTL 269
G+ + GK +EGG+R P + WP I G E S++D+ PT+A LAGAPLP + +
Sbjct: 362 GIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRII 421
Query: 270 DGFDLSPLLLG-TGKSPRQSLFFY-PSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTAD 327
DG DL PLL G + +S + LF Y +Y + VR T +KA FFT +
Sbjct: 422 DGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGC 481
Query: 328 PACHA----SSSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLD 383
A H S +T H+PPLL+D+SKDP E L + P + LK +Q +
Sbjct: 482 FATHVCFCFGSYVTHHDPPLLFDISKDPRERNPL---TPASEPRFYEILKVMQEAADRHT 538
Query: 384 AAVTFGPSQVARGE---DPALQICC 405
+ P Q + P LQ+CC
Sbjct: 539 QTLPEVPDQFSWNNFLWKPWLQLCC 563
Score = 52.8 bits (125), Expect = 6e-07
Identities = 26/60 (43%), Positives = 36/60 (60%), Gaps = 4/60 (6%)
Query: 8 LVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVG----PEGAFLPPHQGFHRFLGI 63
L +S GGLP +E+T A++L +GY T + GKWHLG+ + P H GF+ F GI
Sbjct: 103 LFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGI 162
>gi|31742482 arylsulfatase F precursor [Homo sapiens]
Length = 590
Score = 145 bits (365), Expect = 9e-35
Identities = 133/457 (29%), Positives = 200/457 (43%), Gaps = 69/457 (15%)
Query: 15 GLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQN 74
GLPL E T+A +L +GY TG+ GKWH G+ + H ++ G Y +
Sbjct: 113 GLPLNETTLAALLKKQGYSTGLIGKWHQGLNCDSRSDQCHHPYN--YGFDYYYGMPFTLV 170
Query: 75 LTCFP-PATPCDGGCDQGL------VPIPLLA----NLSVEAQPPWLPGLEARYMAF--- 120
+C+P P+ + + L V I +L LS PWL F
Sbjct: 171 DSCWPDPSRNTELAFESQLWLCVQLVAIAILTLTFGKLSGWVSVPWLLIFSMILFIFLLG 230
Query: 121 -------------------AHDLMADAQRQDRP-------------------FFLYYASH 142
H++ + +R F L+++
Sbjct: 231 YAWFSSHTSPLYWDCLLMRGHEITEQPMKAERAGSIMVKEAISFLERHSKETFLLFFSFL 290
Query: 143 HTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGP-- 200
H H P + F S G +GD++ E+D+ VG ++ AI D GL TLV FT+D+G
Sbjct: 291 HVHTPLPTTDDFTGTSKHGLYGDNVEEMDSMVGKILDAIDDFGLRNNTLVYFTSDHGGHL 350
Query: 201 ETMR--MSRGGCSGLLRCGKGT-TYEGGVREPALAFWPGHIAPG-VTHELASSLDLLPTL 256
E R GG +G+ + GKG +EGG+R P + WPG + G + E S +D+LPT+
Sbjct: 351 EARRGHAQLGGWNGIYKGGKGMGGWEGGIRVPGIVRWPGKVPAGRLIKEPTSLMDILPTV 410
Query: 257 AALAGAPLP-NVTLDGFDLSPLLLGTGK-SPRQSLFFY-PSYPDEVRGVFAVRTGK-YKA 312
A+++G LP + +DG DL PLL G + S + LF Y SY VR + +G +KA
Sbjct: 411 ASVSGGSLPQDRVIDGRDLMPLLQGNVRHSEHEFLFHYCGSYLHAVRWIPKDDSGSVWKA 470
Query: 313 HFFT---QGSAHSDTTADPACHA-SSSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEV 368
H+ T Q A C +T H PPLL+DLS+DP E+ L V
Sbjct: 471 HYVTPVFQPPASGGCYVTSLCRCFGEQVTYHNPPLLFDLSRDPSESTPLTPATEPLHDFV 530
Query: 369 LQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQICC 405
++ + + VT+ S++ +G L+ CC
Sbjct: 531 IKKVANALKEHQETIVPVTYQLSELNQGR-TWLKPCC 566
>gi|58743319 arylsulfatase family, member H [Homo sapiens]
Length = 562
Score = 122 bits (307), Expect = 5e-28
Identities = 87/244 (35%), Positives = 126/244 (51%), Gaps = 13/244 (5%)
Query: 123 DLMADAQRQDR-PFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTAI 181
+ +A +R R PF L+++ H H P S + F RS G +GD++ E+D VG ++ A+
Sbjct: 248 EALAFIERYKREPFLLFFSFLHVHTPLISKKKFVGRSKYGRYGDNVEEMDWMVGKILDAL 307
Query: 182 GDLGLLEETLVIFTADNG----PETMRMSRGGCSGLLRCGKGT-TYEGGVREPALAFWPG 236
L TLV FT+DNG P + GG +G+ + GKG +EGG+R P + WP
Sbjct: 308 DQERLANHTLVYFTSDNGGHLEPLDGAVQLGGWNGIYKGGKGMGGWEGGIRVPGIFRWPS 367
Query: 237 HIAPG-VTHELASSLDLLPTLAALAGAPL-PNVTLDGFDLSPLLLG-TGKSPRQSLFFYP 293
+ G V +E S +D+ PTL+ + G L + +DG +L PLL G S + LF Y
Sbjct: 368 VLEAGRVINEPTSLMDIYPTLSYIGGGILSQDRVIDGQNLMPLLEGRASHSDHEFLFHYC 427
Query: 294 S-YPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTA---DPACHASSSLTAHEPPLLYDLSK 349
Y VR +KAH+ T T A C S +T H+PPLL+D+S+
Sbjct: 428 GVYLHTVRWHQKDCATVWKAHYVTPKFYPEGTGACYGSGICSCSGDVTYHDPPLLFDISR 487
Query: 350 DPGE 353
DP E
Sbjct: 488 DPSE 491
Score = 57.4 bits (137), Expect = 2e-08
Identities = 26/56 (46%), Positives = 35/56 (62%), Gaps = 4/56 (7%)
Query: 14 GGLPLEEVTVAEVLAARGYLTGMAGKWHLGVG----PEGAFLPPHQGFHRFLGIPY 65
GGLP E T A++L RGY TG+ GKWHLG+ + + P + GFH F G+P+
Sbjct: 90 GGLPTNETTFAKLLQHRGYRTGLIGKWHLGLSCASRNDHCYHPLNHGFHYFYGVPF 145
>gi|71852584 arylsulfatase D isoform a precursor [Homo sapiens]
Length = 593
Score = 112 bits (281), Expect = 5e-25
Identities = 76/235 (32%), Positives = 113/235 (48%), Gaps = 17/235 (7%)
Query: 134 PFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVI 193
PF L+ + H H P + +F +S G +GD++ E+D +G ++ AI D GL T
Sbjct: 293 PFLLFLSLLHVHIPLVTTSAFLGKSQHGLYGDNVEEMDWLIGKVLNAIEDNGLKNSTFTY 352
Query: 194 FTADNG----PETMRMSRGGCSGLLRCGKGT-TYEGGVREPALAFWPGHIAPG-VTHELA 247
FT+D+G GG +G+ + GKG +EGG+R P + WPG + G V E
Sbjct: 353 FTSDHGGHLEARDGHSQLGGWNGIYKGGKGMGGWEGGIRVPGIFHWPGVLPAGRVIGEPT 412
Query: 248 SSLDLLPTLAALAGAPLP-NVTLDGFDLSPLLLGT-GKSPRQSLFFYPSYPDEVRGVFAV 305
S +D+ PT+ L G +P + +DG L PLL G +S + LF Y
Sbjct: 413 SLMDVFPTVVQLVGGEVPQDRVIDGHSLVPLLQGAEARSAHEFLFHYCGQHLHAARWHQK 472
Query: 306 RTGKYKAHFFTQGSAHSDTTADPACH-------ASSSLTAHEPPLLYDLSKDPGE 353
+G +T H + AC+ + +T H PPLL+DLS+DP E
Sbjct: 473 DSGSVWKVHYTTPQFHPEGAG--ACYGRGVCPCSGEGVTHHRPPLLFDLSRDPSE 525
Score = 49.3 bits (116), Expect = 7e-06
Identities = 24/57 (42%), Positives = 31/57 (54%), Gaps = 4/57 (7%)
Query: 14 GGLPLEEVTVAEVLAARGYLTGMAGKWHLGVG----PEGAFLPPHQGFHRFLGIPYS 66
GGLP E T A +L GY TG+ GKWH GV + P + GF F G+P++
Sbjct: 123 GGLPENETTFARILQQHGYATGLIGKWHQGVNCASRGDHCHHPLNHGFDYFYGMPFT 179
>gi|59797060 arylsulfatase family, member I [Homo sapiens]
Length = 569
Score = 93.2 bits (230), Expect = 4e-19
Identities = 110/412 (26%), Positives = 160/412 (38%), Gaps = 74/412 (17%)
Query: 2 GMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRFL 61
G+ ++ P LPL++VT+ + L GY T M GKWHLG + LP +GF FL
Sbjct: 110 GLQHSIIRPQQPNCLPLDQVTLPQKLQEAGYSTHMVGKWHLGFYRKEC-LPTRRGFDTFL 168
Query: 62 GI------PYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEA 115
G Y++D CDG G+ L +V W GL
Sbjct: 169 GSLTGNVDYYTYDN--------------CDG---PGVCGFDLHEGENV----AW--GLSG 205
Query: 116 RYMAFAHDLMAD----AQRQDRPFFLYYASHHTHYPQFSGQSFAER------SGRGPFGD 165
+Y + A + RP FLY A H P S + + R R +
Sbjct: 206 QYSTMLYAQRASHILASHSPQRPLFLYVAFQAVHTPLQSPREYLYRYRTMGNVARRKYAA 265
Query: 166 SLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGG 225
+ +D AV + A+ G +++IF++DNG +T GG + LR KGT +EGG
Sbjct: 266 MVTCMDEAVRNITWALKRYGFYNNSVIIFSSDNGGQTF---SGGSNWPLRGRKGTYWEGG 322
Query: 226 VREPALAFWP-GHIAPGVTHELASSLDLLPTLAALAGAPLPNVT-LDGFDLSPLLLGTGK 283
VR P + L D PTL LAG LDG+D+ P +
Sbjct: 323 VRGLGFVHSPLLKRKQRTSRALMHITDWYPTLVGLAGGTTSAADGLDGYDVWPAISEGRA 382
Query: 284 SPRQSLF--FYPSYPDEVRGVF-------------AVRTGKYKAHFFTQGSAHSD----- 323
SPR + P Y G A+R G++K T + D
Sbjct: 383 SPRTEILHNIDPLYNHAQHGSLEGGFGIWNTAVQAAIRVGEWK--LLTGDPGYGDWIPPQ 440
Query: 324 ---TTADPACHASSSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQAL 372
T + + + L+++S DP E +L AG P+V++ L
Sbjct: 441 TLATFPGSWWNLERMASVRQAVWLFNISADPYEREDL----AGQRPDVVRTL 488
>gi|38569405 arylsulfatase B isoform 1 precursor [Homo sapiens]
Length = 533
Score = 84.0 bits (206), Expect = 2e-16
Identities = 105/406 (25%), Positives = 153/406 (37%), Gaps = 76/406 (18%)
Query: 2 GMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRFL 61
G+ ++ P +PL+E + ++L GY T M GKWHLG+ + LP +GF +
Sbjct: 108 GLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKEC-LPTRRGFDTYF 166
Query: 62 GIP------YSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEA 115
G YSH++ C + T C L G +
Sbjct: 167 GYLLGSEDYYSHER--CTLIDALN-VTRCA---------------LDFRDGEEVATGYKN 208
Query: 116 RYMAFAHDLMADA----QRQDRPFFLYYASHHTHYP------QFSGQSFAERSGRGPFGD 165
Y A A ++P FLY A H P F + R +
Sbjct: 209 MYSTNIFTKRAIALITNHPPEKPLFLYLALQSVHEPLQVPEEYLKPYDFIQDKNRHHYAG 268
Query: 166 SLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGG 225
+ +D AVG + A+ GL T+ IF+ DNG +T+ GG + LR K + +EGG
Sbjct: 269 MVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGGQTL---AGGNNWPLRGRKWSLWEGG 325
Query: 226 VREPALAFWPGHIAPGV-THELASSLDLLPTLAALA-GAPLPNVTLDGFDLSPLLLGTGK 283
VR P GV EL D LPTL LA G LDGFD+ +
Sbjct: 326 VRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDVWKTISEGSP 385
Query: 284 SPR----------------------------QSLFFYPSYPDEVRGVFAVRTGKYKAHFF 315
SPR SL Y ++ V A+R G +K
Sbjct: 386 SPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLPEYSAFNTSVHA--AIRHGNWKLLTG 443
Query: 316 TQGSAHSDTTADPACHASSSLTAHEPPL----LYDLSKDPGENYNL 357
G + P+ + S + + +PP L+D+ +DP E ++L
Sbjct: 444 YPGCGY--WFPPPSQYNVSEIPSSDPPTKTLWLFDIDRDPEERHDL 487
>gi|109389362 arylsulfatase J [Homo sapiens]
Length = 599
Score = 83.2 bits (204), Expect = 4e-16
Identities = 100/405 (24%), Positives = 161/405 (39%), Gaps = 50/405 (12%)
Query: 2 GMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRFL 61
G+ ++ P+ LPL+ T+ + L GY T M GKWHLG + +P +GF F
Sbjct: 139 GLQHSIIRPTQPNCLPLDNATLPQKLKEVGYSTHMVGKWHLGFYRKEC-MPTRRGFDTFF 197
Query: 62 GIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEAR--YMA 119
G G T + +P G C L + A + G+ + Y
Sbjct: 198 GSLL----GSGDYYTHYKCDSP--GMCGYDLYE-------NDNAAWDYDNGIYSTQMYTQ 244
Query: 120 FAHDLMADAQRQDRPFFLYYASHHTHYP-QFSGQSFAE-----RSGRGPFGDSLMELDAA 173
++A + +P FLY A H P Q G+ F R + L LD A
Sbjct: 245 RVQQILA-SHNPTKPIFLYIAYQAVHSPLQAPGRYFEHYRSIININRRRYAAMLSCLDEA 303
Query: 174 VGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAF 233
+ + A+ G +++I+++DNG + + GG + LR KGT +EGG+R
Sbjct: 304 INNVTLALKTYGFYNNSIIIYSSDNGGQP---TAGGSNWPLRGSKGTYWEGGIRAVGFVH 360
Query: 234 WPGHIAPG-VTHELASSLDLLPTLAALAGAPL-PNVTLDGFDLSPLLLGTGKSPRQSLF- 290
P G V EL D PTL +LA + ++ LDG+D+ + +SPR +
Sbjct: 361 SPLLKNKGTVCKELVHITDWYPTLISLAEGQIDEDIQLDGYDIWETISEGLRSPRVDILH 420
Query: 291 -FYPSYPDEVRGVFAVRTGKYKA-----------HFFTQGSAHSDTTADPAC-------- 330
P Y G +A G + T +SD +
Sbjct: 421 NIDPIYTKAKNGSWAAGYGIWNTAIQSAIRVQHWKLLTGNPGYSDWVPPQSFSNLGPNRW 480
Query: 331 -HASSSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQ 374
+ +L+ + L++++ DP E +L G ++L+ L Q
Sbjct: 481 HNERITLSTGKSVWLFNITADPYERVDLSNRYPGIVKKLLRRLSQ 525
>gi|38569407 arylsulfatase B isoform 2 precursor [Homo sapiens]
Length = 413
Score = 81.6 bits (200), Expect = 1e-15
Identities = 87/306 (28%), Positives = 120/306 (39%), Gaps = 40/306 (13%)
Query: 2 GMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRFL 61
G+ ++ P +PL+E + ++L GY T M GKWHLG+ + LP +GF +
Sbjct: 108 GLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKEC-LPTRRGFDTYF 166
Query: 62 GIP------YSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEA 115
G YSH++ C + T C L G +
Sbjct: 167 GYLLGSEDYYSHER--CTLIDALN-VTRCA---------------LDFRDGEEVATGYKN 208
Query: 116 RYMAFAHDLMADA----QRQDRPFFLYYASHHTHYP------QFSGQSFAERSGRGPFGD 165
Y A A ++P FLY A H P F + R +
Sbjct: 209 MYSTNIFTKRAIALITNHPPEKPLFLYLALQSVHEPLQVPEEYLKPYDFIQDKNRHHYAG 268
Query: 166 SLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGG 225
+ +D AVG + A+ GL T+ IF+ DNG +T+ GG + LR K + +EGG
Sbjct: 269 MVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGGQTL---AGGNNWPLRGRKWSLWEGG 325
Query: 226 VREPALAFWPGHIAPGV-THELASSLDLLPTLAALA-GAPLPNVTLDGFDLSPLLLGTGK 283
VR P GV EL D LPTL LA G LDGFD+ +
Sbjct: 326 VRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDVWKTISEGSP 385
Query: 284 SPRQSL 289
SPR L
Sbjct: 386 SPRIEL 391
>gi|39930577 arylsulfatase K [Homo sapiens]
Length = 536
Score = 65.9 bits (159), Expect = 7e-11
Identities = 61/213 (28%), Positives = 92/213 (43%), Gaps = 39/213 (18%)
Query: 169 ELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVRE 228
E DA +G ++ A+ L LL++T+VI+++D+G M + K + YE
Sbjct: 285 ETDAMLGEIILALHQLDLLQKTIVIYSSDHGELAMEHR--------QFYKMSMYEASAHV 336
Query: 229 PALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQS 288
P L PG A + S +D+ PT+ +AG PLP L G+ L PL T K+ +
Sbjct: 337 PLLMMGPGIKAGLQVSNVVSLVDIYPTMLDIAGIPLPQ-NLSGYSLLPLSSETFKNEHKV 395
Query: 289 LFFYPSY-PDEVRG------VFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEP 341
+P + E G + +RT +K ++ G A
Sbjct: 396 KNLHPPWILSEFHGCNVNASTYMLRTNHWKYIAYSDG-------------------ASIL 436
Query: 342 PLLYDLSKDPGENYNLLGGVAGATPEVLQALKQ 374
P L+DLS DP E L VA PE+ +L Q
Sbjct: 437 PQLFDLSSDPDE----LTNVAVKFPEITYSLDQ 465
>gi|4506919 N-sulfoglucosamine sulfohydrolase precursor [Homo
sapiens]
Length = 502
Score = 54.3 bits (129), Expect = 2e-07
Identities = 90/359 (25%), Positives = 121/359 (33%), Gaps = 104/359 (28%)
Query: 130 RQDRPFFLYYASHHTH-----YPQFSGQSFAERSGRGPFG-------------------- 164
+ DRPFFLY A H H PQ+ +F E+ G G G
Sbjct: 166 QDDRPFFLYVAFHDPHRCGHSQPQYG--TFCEKFGNGESGMGRIPDWTPQAYDPLDVLVP 223
Query: 165 -----------------DSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSR 207
++ +D VG ++ + D G+L +TLVIFT+DNG
Sbjct: 224 YFVPNTPAARADLAAQYTTVGRMDQGVGLVLQELRDAGVLNDTLVIFTSDNGIP------ 277
Query: 208 GGCSGLLRCGKGTTYEGGVREPALAFWPGHIA--PGVTHELASSLDLLPTLAALAGAPLP 265
G+ Y G EP L P H V+ S LDL PT+ P P
Sbjct: 278 ------FPSGRTNLYWPGTAEPLLVSSPEHPKRWGQVSEAYVSLLDLTPTILDWFSIPYP 331
Query: 266 N--------VTLDGFDLSPLL--------LGTGKSPRQSLFFYPSYPDEVRGVFAVRTGK 309
+ + L G L P L + +S + YP + R V
Sbjct: 332 SYAIFGSKTIHLTGRSLLPALEAEPLWATVFGSQSHHEVTMSYPMRSVQHRHFRLVHNLN 391
Query: 310 YKAHFFTQGSAHSDTTADPACHASSSLTAHEPP---------------LLYDLSKDPGEN 354
+K F + T + + TA +P LYD S+DP E
Sbjct: 392 FKMPFPIDQDFYVSPTFQDLLNRT---TAGQPTGWYKDLRHYYYRARWELYDRSRDPHET 448
Query: 355 YNLLGGVAGATPEVLQALKQL--QLLKAQLDAAVTFGPSQVARGEDPALQICCHPGCTP 411
NL P Q L+ L QL K Q + T P A D L+ P C P
Sbjct: 449 QNL-----ATDPRFAQLLEMLRDQLAKWQWE---THDPWVCA--PDGVLEEKLSPQCQP 497
>gi|4504061 glucosamine (N-acetyl)-6-sulfatase precursor [Homo
sapiens]
Length = 552
Score = 53.1 bits (126), Expect = 5e-07
Identities = 42/134 (31%), Positives = 63/134 (47%), Gaps = 15/134 (11%)
Query: 148 QFSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSR 207
QF +F +R +L+ +D V L+ + G L T + +T+DNG T + S
Sbjct: 283 QFLDNAFRKR------WQTLLSVDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFS- 335
Query: 208 GGCSGLLRCGKGTTYEGGVREPALAFWPGHIAPGVTHE-LASSLDLLPTLAALAGAPLPN 266
L K YE ++ P L PG I P T + L +++DL PT+ +AG L
Sbjct: 336 ------LPIDKRQLYEFDIKVPLLVRGPG-IKPNQTSKMLVANIDLGPTILDIAGYDLNK 388
Query: 267 VTLDGFDLSPLLLG 280
+DG L P+L G
Sbjct: 389 TQMDGMSLLPILRG 402
>gi|71852586 arylsulfatase D isoform b precursor [Homo sapiens]
Length = 382
Score = 49.3 bits (116), Expect = 7e-06
Identities = 24/57 (42%), Positives = 31/57 (54%), Gaps = 4/57 (7%)
Query: 14 GGLPLEEVTVAEVLAARGYLTGMAGKWHLGVG----PEGAFLPPHQGFHRFLGIPYS 66
GGLP E T A +L GY TG+ GKWH GV + P + GF F G+P++
Sbjct: 123 GGLPENETTFARILQQHGYATGLIGKWHQGVNCASRGDHCHHPLNHGFDYFYGMPFT 179
Score = 32.3 bits (72), Expect = 0.83
Identities = 13/38 (34%), Positives = 22/38 (57%)
Query: 134 PFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELD 171
PF L+ + H H P + +F +S G +GD++ E+D
Sbjct: 293 PFLLFLSLLHVHIPLVTTSAFLGKSQHGLYGDNVEEMD 330
>gi|240255483 sulfatase 2 isoform a precursor [Homo sapiens]
Length = 870
Score = 48.1 bits (113), Expect = 1e-05
Identities = 33/113 (29%), Positives = 57/113 (50%), Gaps = 8/113 (7%)
Query: 166 SLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGG 225
+LM +D ++ T+ + + G L+ T +++TAD+G G GL++ GK YE
Sbjct: 286 TLMSVDDSMETIYNMLVETGELDNTYIVYTADHGYHI------GQFGLVK-GKSMPYEFD 338
Query: 226 VREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLL 278
+R P P A + + ++DL PT+ +AG +P +DG + LL
Sbjct: 339 IRVPFYVRGPNVEAGCLNPHIVLNIDLAPTILDIAGLDIP-ADMDGKSILKLL 390
>gi|240255478 sulfatase 2 isoform b precursor [Homo sapiens]
Length = 867
Score = 48.1 bits (113), Expect = 1e-05
Identities = 33/113 (29%), Positives = 57/113 (50%), Gaps = 8/113 (7%)
Query: 166 SLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGG 225
+LM +D ++ T+ + + G L+ T +++TAD+G G GL++ GK YE
Sbjct: 286 TLMSVDDSMETIYNMLVETGELDNTYIVYTADHGYHI------GQFGLVK-GKSMPYEFD 338
Query: 226 VREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLL 278
+R P P A + + ++DL PT+ +AG +P +DG + LL
Sbjct: 339 IRVPFYVRGPNVEAGCLNPHIVLNIDLAPTILDIAGLDIP-ADMDGKSILKLL 390
>gi|29789100 sulfatase 2 isoform a precursor [Homo sapiens]
Length = 870
Score = 48.1 bits (113), Expect = 1e-05
Identities = 33/113 (29%), Positives = 57/113 (50%), Gaps = 8/113 (7%)
Query: 166 SLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGG 225
+LM +D ++ T+ + + G L+ T +++TAD+G G GL++ GK YE
Sbjct: 286 TLMSVDDSMETIYNMLVETGELDNTYIVYTADHGYHI------GQFGLVK-GKSMPYEFD 338
Query: 226 VREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLL 278
+R P P A + + ++DL PT+ +AG +P +DG + LL
Sbjct: 339 IRVPFYVRGPNVEAGCLNPHIVLNIDLAPTILDIAGLDIP-ADMDGKSILKLL 390
>gi|189571643 sulfatase 1 [Homo sapiens]
Length = 871
Score = 46.2 bits (108), Expect = 6e-05
Identities = 34/113 (30%), Positives = 55/113 (48%), Gaps = 8/113 (7%)
Query: 166 SLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGG 225
+LM +D +V L + + G LE T +I+TAD+G G GL++ GK Y+
Sbjct: 285 TLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHI------GQFGLVK-GKSMPYDFD 337
Query: 226 VREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLL 278
+R P P + ++ ++DL PT+ +AG P +DG + LL
Sbjct: 338 IRVPFFIRGPSVEPGSIVPQIVLNIDLAPTILDIAGLDTP-PDVDGKSVLKLL 389
>gi|189571641 sulfatase 1 [Homo sapiens]
Length = 871
Score = 46.2 bits (108), Expect = 6e-05
Identities = 34/113 (30%), Positives = 55/113 (48%), Gaps = 8/113 (7%)
Query: 166 SLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGG 225
+LM +D +V L + + G LE T +I+TAD+G G GL++ GK Y+
Sbjct: 285 TLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHI------GQFGLVK-GKSMPYDFD 337
Query: 226 VREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLL 278
+R P P + ++ ++DL PT+ +AG P +DG + LL
Sbjct: 338 IRVPFFIRGPSVEPGSIVPQIVLNIDLAPTILDIAGLDTP-PDVDGKSVLKLL 389
>gi|189571638 sulfatase 1 [Homo sapiens]
Length = 871
Score = 46.2 bits (108), Expect = 6e-05
Identities = 34/113 (30%), Positives = 55/113 (48%), Gaps = 8/113 (7%)
Query: 166 SLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGG 225
+LM +D +V L + + G LE T +I+TAD+G G GL++ GK Y+
Sbjct: 285 TLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHI------GQFGLVK-GKSMPYDFD 337
Query: 226 VREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLL 278
+R P P + ++ ++DL PT+ +AG P +DG + LL
Sbjct: 338 IRVPFFIRGPSVEPGSIVPQIVLNIDLAPTILDIAGLDTP-PDVDGKSVLKLL 389
>gi|189571636 sulfatase 1 [Homo sapiens]
Length = 871
Score = 46.2 bits (108), Expect = 6e-05
Identities = 34/113 (30%), Positives = 55/113 (48%), Gaps = 8/113 (7%)
Query: 166 SLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGG 225
+LM +D +V L + + G LE T +I+TAD+G G GL++ GK Y+
Sbjct: 285 TLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHI------GQFGLVK-GKSMPYDFD 337
Query: 226 VREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLL 278
+R P P + ++ ++DL PT+ +AG P +DG + LL
Sbjct: 338 IRVPFFIRGPSVEPGSIVPQIVLNIDLAPTILDIAGLDTP-PDVDGKSVLKLL 389
>gi|4557659 iduronate-2-sulfatase isoform a precursor [Homo sapiens]
Length = 550
Score = 38.9 bits (89), Expect = 0.009
Identities = 35/135 (25%), Positives = 55/135 (40%), Gaps = 33/135 (24%)
Query: 156 ERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLR 215
+R R + S+ LD VG L++A+ DL L T++ FT+D+G + G
Sbjct: 293 QRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHG---WALGEHG-----E 344
Query: 216 CGKGTTYEGGVREPALAFWPGHIA------------------------PG-VTHELASSL 250
K + ++ P + + PG A PG + +L +
Sbjct: 345 WAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELV 404
Query: 251 DLLPTLAALAGAPLP 265
L PTLA LAG +P
Sbjct: 405 SLFPTLAGLAGLQVP 419
>gi|39752687 hypothetical protein LOC375791 [Homo sapiens]
Length = 144
Score = 38.9 bits (89), Expect = 0.009
Identities = 19/41 (46%), Positives = 23/41 (56%), Gaps = 5/41 (12%)
Query: 380 AQLDAAVTF-GPSQVARGEDPALQICCHPGCTPRPACCHCP 419
+Q A +T+ GP V RG+D A CC P C CCHCP
Sbjct: 94 SQRQAGLTYAGPPPVGRGDDIAHHCCCCPCC----HCCHCP 130
>gi|195947389 autotaxin isoform 3 preproprotein [Homo sapiens]
Length = 888
Score = 35.8 bits (81), Expect = 0.075
Identities = 24/69 (34%), Positives = 32/69 (46%), Gaps = 10/69 (14%)
Query: 143 HTHYPQFSGQSFAERSGRGPFG----DSLMELDAAVGTLMTAIGDLGLLEETLVIFTADN 198
++ P FSG + GPFG + L E+D VG LM + L L VIF D+
Sbjct: 307 YSEQPDFSGHKY------GPFGPEMTNPLREIDKIVGQLMDGLKQLKLHRCVNVIFVGDH 360
Query: 199 GPETMRMSR 207
G E + R
Sbjct: 361 GMEDVTCDR 369
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.139 0.445
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,401,709
Number of Sequences: 37866
Number of extensions: 1003340
Number of successful extensions: 2683
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 32
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 2589
Number of HSP's gapped (non-prelim): 62
length of query: 423
length of database: 18,247,518
effective HSP length: 105
effective length of query: 318
effective length of database: 14,271,588
effective search space: 4538364984
effective search space used: 4538364984
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.