Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 145312241
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|145312241 differentially expressed in FDCP 6 homolog [Homo
sapiens]
(631 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|145312241 differentially expressed in FDCP 6 homolog [Homo sa... 1253 0.0
gi|93102364 SWAP-70 protein [Homo sapiens] 510 e-144
gi|148746195 trichohyalin [Homo sapiens] 108 1e-23
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 98 2e-20
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 96 8e-20
gi|221139761 zinc finger protein 853 [Homo sapiens] 96 1e-19
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 96 1e-19
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 95 2e-19
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 94 3e-19
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 93 6e-19
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 92 1e-18
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 92 1e-18
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 92 1e-18
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 92 1e-18
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 92 1e-18
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 92 1e-18
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 92 1e-18
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 92 1e-18
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 92 2e-18
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 92 2e-18
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 92 2e-18
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 92 2e-18
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 92 2e-18
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 92 2e-18
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 91 2e-18
gi|239745299 PREDICTED: hypothetical protein [Homo sapiens] 91 3e-18
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 91 4e-18
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 90 5e-18
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 87 6e-17
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 85 2e-16
>gi|145312241 differentially expressed in FDCP 6 homolog [Homo
sapiens]
Length = 631
Score = 1253 bits (3243), Expect = 0.0
Identities = 631/631 (100%), Positives = 631/631 (100%)
Query: 1 MALRKELLKSIWYAFTALDVEKSGKVSKSQLKVLSHNLYTVLHIPHDPVALEEHFRDDDD 60
MALRKELLKSIWYAFTALDVEKSGKVSKSQLKVLSHNLYTVLHIPHDPVALEEHFRDDDD
Sbjct: 1 MALRKELLKSIWYAFTALDVEKSGKVSKSQLKVLSHNLYTVLHIPHDPVALEEHFRDDDD 60
Query: 61 GPVSSQGYMPYLNKYILDKVEEGAFVKEHFDELCWTLTAKKNYRADSNGNSMLSNQDAFR 120
GPVSSQGYMPYLNKYILDKVEEGAFVKEHFDELCWTLTAKKNYRADSNGNSMLSNQDAFR
Sbjct: 61 GPVSSQGYMPYLNKYILDKVEEGAFVKEHFDELCWTLTAKKNYRADSNGNSMLSNQDAFR 120
Query: 121 LWCLFNFLSEDKYPLIMVPDEVEYLLKKVLSSMSLEVSLGELEELLAQEAQVAQTTGGLS 180
LWCLFNFLSEDKYPLIMVPDEVEYLLKKVLSSMSLEVSLGELEELLAQEAQVAQTTGGLS
Sbjct: 121 LWCLFNFLSEDKYPLIMVPDEVEYLLKKVLSSMSLEVSLGELEELLAQEAQVAQTTGGLS 180
Query: 181 VWQFLELFNSGRCLRGVGRDTLSMAIHEVYQELIQDVLKQGYLWKRGHLRRNWAERWFQL 240
VWQFLELFNSGRCLRGVGRDTLSMAIHEVYQELIQDVLKQGYLWKRGHLRRNWAERWFQL
Sbjct: 181 VWQFLELFNSGRCLRGVGRDTLSMAIHEVYQELIQDVLKQGYLWKRGHLRRNWAERWFQL 240
Query: 241 QPSCLCYFGSEECKEKRGIIPLDAHCCVEVLPDRDGKRCMFCVKTANRTYEMSASDTRQR 300
QPSCLCYFGSEECKEKRGIIPLDAHCCVEVLPDRDGKRCMFCVKTANRTYEMSASDTRQR
Sbjct: 241 QPSCLCYFGSEECKEKRGIIPLDAHCCVEVLPDRDGKRCMFCVKTANRTYEMSASDTRQR 300
Query: 301 QEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERK 360
QEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERK
Sbjct: 301 QEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERK 360
Query: 361 LQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEE 420
LQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEE
Sbjct: 361 LQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEE 420
Query: 421 AARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQ 480
AARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQ
Sbjct: 421 AARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQ 480
Query: 481 ERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNV 540
ERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNV
Sbjct: 481 ERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNV 540
Query: 541 KHWNVQMNRLMHPIEPGDKRPVTSSSFSGFQPPLLAHRDSSLKRLTRWGSQGNRTPSPNS 600
KHWNVQMNRLMHPIEPGDKRPVTSSSFSGFQPPLLAHRDSSLKRLTRWGSQGNRTPSPNS
Sbjct: 541 KHWNVQMNRLMHPIEPGDKRPVTSSSFSGFQPPLLAHRDSSLKRLTRWGSQGNRTPSPNS 600
Query: 601 NEQQKSLNGGDEAPAPASTPQEDKLDPAPEN 631
NEQQKSLNGGDEAPAPASTPQEDKLDPAPEN
Sbjct: 601 NEQQKSLNGGDEAPAPASTPQEDKLDPAPEN 631
>gi|93102364 SWAP-70 protein [Homo sapiens]
Length = 585
Score = 510 bits (1314), Expect = e-144
Identities = 268/588 (45%), Positives = 392/588 (66%), Gaps = 17/588 (2%)
Query: 2 ALRKELLKSIWYAFTALDVEKSGKVSKSQLKVLSHNLYTVLHIPHDPVALEEHFRDDDDG 61
+L++ELLK+IW+AFTALD + SGKVSKSQLKVLSHNL TVL +PHDPVALEEHFRDDD+G
Sbjct: 3 SLKEELLKAIWHAFTALDQDHSGKVSKSQLKVLSHNLCTVLKVPHDPVALEEHFRDDDEG 62
Query: 62 PVSSQGYMPYLNKYILDKVEEGAFVKEHFDELCWTLTAKKNYRADSNGNSMLSNQDAFRL 121
PVS+QGYMPYLN++IL+KV++ F K F+ +CWTL KKN + +++ +DAF++
Sbjct: 63 PVSNQGYMPYLNRFILEKVQDN-FDKIEFNRMCWTLCVKKNL---TKNPLLITEEDAFKI 118
Query: 122 WCLFNFLSEDKYPLIMVPDEVEYLLKKVLSSMSLEVSLGELEELLAQEAQVAQTTGGLSV 181
W +FNFLSEDKYPLI+V +E+EYLLKK+ +M + E+ + + GLS
Sbjct: 119 WVIFNFLSEDKYPLIIVSEEIEYLLKKLTEAMG---GGWQQEQFEHYKINFDDSKNGLSA 175
Query: 182 WQFLELFNSGRCLRGVGRDTLSMAIHEVYQELIQDVLKQGYLWKRGHLRRNWAERWFQLQ 241
W+ +EL +G+ +G+ R T+SMAI+EV+ ELI DVLKQGY+ K+GH R+NW ERWF L+
Sbjct: 176 WELIELIGNGQFSKGMDRQTVSMAINEVFNELILDVLKQGYMMKKGHRRKNWTERWFVLK 235
Query: 242 PSCLCYFGSEECKEKRGIIPLDAHCCVEVLPDRDGKRCMFCVKTANRTYEMSASDTRQRQ 301
P+ + Y+ SE+ K+K+G I LD +CCVE LPD+DGK+C+F VK ++T+E+SASD +++Q
Sbjct: 236 PNIISYYVSEDLKDKKGDILLDENCCVESLPDKDGKKCLFLVKCFDKTFEISASDKKKKQ 295
Query: 302 EWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLR-LQQLQEEKERK 360
EW AI I L G HK+ +Q+R+E R +++ A++EEL R +++LQ E K
Sbjct: 296 EWIQAIHSTIHLLKLGSPPPHKEARQRRKELR----KKQLAEQEELERQMKELQAANESK 351
Query: 361 LQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEE 420
QELE +++ +A EEE++R ELQ +L + R M+ ++ K E
Sbjct: 352 QQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSE 411
Query: 421 AARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQ 480
+ QR++ELE+M +LQEAL+ E +AR+DEE+VR Q RLLEEE K +L + EQ
Sbjct: 412 LEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQ 471
Query: 481 ERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNV 540
++ I+ + EK+EL+ + + ++LQ+A +QLE++ R++A E E ++KL A+
Sbjct: 472 QQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKT 531
Query: 541 KHWNVQM---NRLMHPIEPGDKRP--VTSSSFSGFQPPLLAHRDSSLK 583
K W ++ L+ IEPG K P +T+ + F L R+ + K
Sbjct: 532 KSWKDKVAHHEGLIRLIEPGSKNPHLITNWGPAAFTEAELEEREKNWK 579
Score = 45.4 bits (106), Expect = 2e-04
Identities = 44/185 (23%), Positives = 75/185 (40%), Gaps = 18/185 (9%)
Query: 425 RQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYI 484
RQR KEL + Q QE L+ ++K L E K ++L ++++ E
Sbjct: 320 RQRRKELRKKQLAEQEELERQMK-------------ELQAANESKQQELEAVRKKLEEAA 366
Query: 485 ERA-QQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHW 543
RA ++EK+ LQ ++ Q+R +LE + RQ+ +E V +L Q V+
Sbjct: 367 SRAAEEEKKRLQTQVELQARF----STELEREKLIRQQMEEQVAQKSSELEQYLQRVREL 422
Query: 544 NVQMNRLMHPIEPGDKRPVTSSSFSGFQPPLLAHRDSSLKRLTRWGSQGNRTPSPNSNEQ 603
+L +E + + Q LL S L +W + + E+
Sbjct: 423 EDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEK 482
Query: 604 QKSLN 608
Q+ N
Sbjct: 483 QELEN 487
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 108 bits (270), Expect = 1e-23
Identities = 74/264 (28%), Positives = 148/264 (56%), Gaps = 17/264 (6%)
Query: 296 DTRQRQEWTAAIQMAIRLQAEG-KTSLHKDLKQKRRE-----QREQRERRRAAKEEELLR 349
+ +R++W + R + E K L +D +++RRE + E+R ++ +E++L R
Sbjct: 450 EQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRR 509
Query: 350 LQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQ--HRELQQALEGQLREAEQAR 407
Q+ + E+ K QE E + + ++E+ L+ E+E RR Q RE ++ LE + RE R
Sbjct: 510 EQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKR 569
Query: 408 ASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEE 467
+ +L + E R++QR+K E ++RL++ L+ E R ++E R + + E EE
Sbjct: 570 EQEERRDQLLKREEERRQQRLK--REQEERLEQRLKREEVERLEQEERREQRLKREEPEE 627
Query: 468 EKLKQLMQLKEEQER---YIERAQQEKEELQQEMAQQSRSLQQ-AQQQLEEVRQNRQRAD 523
E+ +QL++ +E++ER + R QQE+ E + + ++ L+Q +++ EE R+ ++ A+
Sbjct: 628 ERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAE 687
Query: 524 EDVEAAQRKLRQASTNVKHWNVQM 547
E+ E A+ +++ + + W Q+
Sbjct: 688 EEQEQARERIK---SRIPKWQWQL 708
Score = 106 bits (265), Expect = 6e-23
Identities = 82/267 (30%), Positives = 145/267 (54%), Gaps = 36/267 (13%)
Query: 298 RQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEK 357
R+RQE Q +R + + + ++ ++++ E+REQ+ERR ++EE Q +E++
Sbjct: 288 RERQEEEQQ-QQRLRREQQLRRKQEEERREQQEERREQQERRE--QQEERREQQLRREQE 344
Query: 358 ERKLQELELLQEAQRQAERLLQEEEERRRSQ--HRELQQALEGQLREAEQARASMQ--AE 413
ER+ Q+L QE +R+ ++L +E+EE RR Q RE Q E QLR +Q R Q E
Sbjct: 345 ERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRRE 404
Query: 414 MELKEEEAARQRQRIKELEEM--------------QQRLQEALQLEVKARRD-----EES 454
+L+ E+ R+ Q+++ +++ Q+R ++ L+ E + RRD EE+
Sbjct: 405 QQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEET 464
Query: 455 VRIAQTR-----LLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQ 509
R Q R ++EEE+ ++ ++L+EE+ R QQE+ E Q Q+ R Q+ +
Sbjct: 465 ERHEQERRKQQLKRDQEEERRERWLKLEEEE----RREQQERREQQLRREQEERREQRLK 520
Query: 510 QQLEEVR-QNRQRADEDVEAAQRKLRQ 535
+Q EE R Q R R+++ + Q + R+
Sbjct: 521 RQEEEERLQQRLRSEQQLRREQEERRE 547
Score = 105 bits (261), Expect = 2e-22
Identities = 82/252 (32%), Positives = 145/252 (57%), Gaps = 30/252 (11%)
Query: 296 DTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRR---AAKEEELLRLQQ 352
+ R+RQE + LQ E + L ++ +++RR++ E++ R++ +EE+LLR
Sbjct: 979 EKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLR--- 1035
Query: 353 LQEEKERKLQELELL----QEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARA 408
+E ++R+LQE E +E Q++ E+LL EE E RR Q E Q E +L++ E
Sbjct: 1036 -EEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEE---- 1090
Query: 409 SMQAEMELKEEEAARQRQ----RIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLE 464
E L+EE R+RQ + +E EE+QQ ++ L+ E + RR +E R Q R E
Sbjct: 1091 ----EQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELER--QYREEE 1144
Query: 465 EEEEKLKQLMQLKEEQER--YIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRA 522
E +++ +QL++ + E+ R +ER +E+EELQQE + + L++ Q++ + R+ + R
Sbjct: 1145 EVQQEEEQLLREEPEKRRRQELERQYREEEELQQE---EEQLLREEQEKRRQERERQYRE 1201
Query: 523 DEDVEAAQRKLR 534
+E+++ +RK R
Sbjct: 1202 EEELQRQKRKQR 1213
Score = 104 bits (260), Expect = 2e-22
Identities = 84/270 (31%), Positives = 143/270 (52%), Gaps = 32/270 (11%)
Query: 296 DTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQ--- 352
+ R+RQEW + LQ E + L ++ RE+R +ER R +EEE L+ ++
Sbjct: 1009 EKRRRQEWERQYRKKDELQQE-----EEQLLREEREKRRLQERERQYREEEELQQEEEQL 1063
Query: 353 LQEEKE-RKLQELELL----QEAQRQAERLLQEEEERRRSQHR--------ELQQALEGQ 399
L EE+E R+ QELE +E Q++ E+LL+EE E+RR Q R ELQQ E
Sbjct: 1064 LGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQL 1123
Query: 400 LREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQ 459
LRE + R + E + +EEE +Q + EE ++R ++ L+ + R+EE ++ +
Sbjct: 1124 LREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELE---RQYREEEELQQEE 1180
Query: 460 TRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQN- 518
+LL EE+EK +Q + + +E ++R Q+ K+ + E + Q ++ VR N
Sbjct: 1181 EQLLREEQEKRRQERERQYREEEELQR-QKRKQRYRDEDQRSDLKWQWEPEKENAVRDNK 1239
Query: 519 ---RQRADE---DVEAAQRKLRQASTNVKH 542
+ R +E +E +Q + RQ+ +++H
Sbjct: 1240 VYCKGRENEQFRQLEDSQLRDRQSQQDLQH 1269
Score = 102 bits (254), Expect = 1e-21
Identities = 76/263 (28%), Positives = 136/263 (51%), Gaps = 29/263 (11%)
Query: 298 RQRQEWTAAIQMAIRLQAEGKTSLHKDLKQK--RREQREQRERRRAAKEEELLRLQQLQE 355
R++QE Q R + + + ++ +++ RREQ E+RE++ ++EE R QQL+
Sbjct: 307 RRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRR 366
Query: 356 EKERKLQELELLQEAQRQAERLLQEEEERRRSQH--RELQQALEGQLREAEQARASMQAE 413
E+E + +E +L +E Q + E+ L+ E++ RR Q RE Q E QLR +Q R Q
Sbjct: 367 EQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 426
Query: 414 MELKEE------EAARQRQRIKELEEM---------------QQRLQEALQLEVKARRDE 452
E +EE E R+ QR+K +E Q+R ++ L+ + + R E
Sbjct: 427 REQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRE 486
Query: 453 ESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQL 512
+++ + E++E + +QL + +EE+ + Q+E+E LQQ + RS QQ +++
Sbjct: 487 RWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRL----RSEQQLRREQ 542
Query: 513 EEVRQNRQRADEDVEAAQRKLRQ 535
EE R+ + +E+ Q + Q
Sbjct: 543 EERREQLLKREEEKRLEQERREQ 565
Score = 102 bits (253), Expect = 1e-21
Identities = 73/250 (29%), Positives = 135/250 (54%), Gaps = 28/250 (11%)
Query: 311 IRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEA 370
+R + + + + L+++++ +R+Q E RR +EE + ++ ++++ER+ Q+L QE
Sbjct: 286 LRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEE 345
Query: 371 QRQAERLLQEEEERRRSQHRELQ--QALEGQLREAEQARASMQ--AEMELKEEEAARQRQ 426
+R+ + ++EEERR Q R Q + E QLR +Q R Q E +L+ E+ R+ Q
Sbjct: 346 RREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQ 405
Query: 427 RIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQ-------LMQLKEE 479
+++ E Q R ++ L+ E + RR++E R Q E E++LK+ ++ +EE
Sbjct: 406 QLR--REQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEE 463
Query: 480 QERY--------IERAQQE-------KEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADE 524
ER+ ++R Q+E K E ++ QQ R QQ +++ EE R+ R + E
Sbjct: 464 TERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQE 523
Query: 525 DVEAAQRKLR 534
+ E Q++LR
Sbjct: 524 EEERLQQRLR 533
Score = 99.8 bits (247), Expect = 7e-21
Identities = 72/257 (28%), Positives = 141/257 (54%), Gaps = 25/257 (9%)
Query: 296 DTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQE 355
+ R++QE Q+ + + L ++ +++RREQ+ +RE+ +E++L R QQL+
Sbjct: 326 ERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRR 385
Query: 356 EKE-------------RKLQEL----ELLQEAQRQAERLLQEEEERRRSQHRELQQALEG 398
E++ R+ Q+L +L +E Q + E+ L+ E+E R + + Q+ E
Sbjct: 386 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQ 445
Query: 399 QL-REAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRI 457
+L RE E+ R ++ E E + E R++Q++K +E ++R + L+LE + RR+++ R
Sbjct: 446 RLKREQEERRDWLKREEETERHEQERRKQQLKRDQE-EERRERWLKLEEEERREQQERRE 504
Query: 458 AQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQ 517
Q R E+EE+ +Q ++ +EE+ER +R + E QQ +Q +Q ++ EE R
Sbjct: 505 QQLR--REQEERREQRLKRQEEEERLQQRLRSE----QQLRREQEERREQLLKREEEKRL 558
Query: 518 NRQRADEDVEAAQRKLR 534
++R ++ ++ Q + R
Sbjct: 559 EQERREQRLKREQEERR 575
Score = 99.4 bits (246), Expect = 9e-21
Identities = 72/282 (25%), Positives = 145/282 (51%), Gaps = 25/282 (8%)
Query: 269 EVLPDRDGKRCMFCVKTANRTYEMSASDTRQRQ----------EWTAAIQMAIRLQAEGK 318
E PD + R ++ + E R+RQ EW + +R + E
Sbjct: 202 EEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKR-ETVLRKEEE-- 258
Query: 319 TSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLL 378
L ++ Q++RE +E+ E+ R + +EL R +Q +E+++++L+ + L+ Q + R
Sbjct: 259 -KLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQ 317
Query: 379 QEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRL 438
QEE ++ + + ++ E QLR ++ R Q E +EE +Q +R +E E +Q+L
Sbjct: 318 QEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQL 377
Query: 439 QEALQL--EVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQ 496
+ QL E + RR+++ R Q R E++L++ QL+ EQ+ + R QQ + E ++
Sbjct: 378 RREQQLRREQQLRREQQLRREQQLR----REQQLRREQQLRREQQ--LRREQQLRREQEE 431
Query: 497 EMAQQSRSLQQAQQQLEEVRQNRQ---RADEDVEAAQRKLRQ 535
E +Q ++ +Q+L+ ++ R+ + +E+ E +++ R+
Sbjct: 432 ERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRK 473
Score = 95.5 bits (236), Expect = 1e-19
Identities = 89/286 (31%), Positives = 146/286 (51%), Gaps = 52/286 (18%)
Query: 296 DTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQE 355
+ R+ Q+ Q+ Q + L ++ +Q RREQ+ +RE++ +E++L R QQL+
Sbjct: 370 EERREQQLRREQQLRREQQLRREQQLRRE-QQLRREQQLRREQQ-LRREQQLRREQQLRR 427
Query: 356 EKERKLQELELLQEAQRQAERLLQEEEERR-----------RSQHRELQQALEGQ----- 399
E+E + E + E +R+ +RL +E+EERR Q R QQ Q
Sbjct: 428 EQEEERHEQK--HEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERR 485
Query: 400 -----LREAEQARASMQAEMELKEEEAARQRQRIKELEE---MQQRLQEALQL--EVKAR 449
L E E+ + E +L+ E+ R+ QR+K EE +QQRL+ QL E + R
Sbjct: 486 ERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEER 545
Query: 450 RD-----EESVRIAQ----TRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEE-----LQ 495
R+ EE R+ Q RL E+EE+ QL LK E+ER +R ++E+EE L+
Sbjct: 546 REQLLKREEEKRLEQERREQRLKREQEERRDQL--LKREEERRQQRLKREQEERLEQRLK 603
Query: 496 QEMAQQSRSLQQAQQQL------EEVRQNRQRADEDVEAAQRKLRQ 535
+E ++ ++ +Q+L EE RQ +++E E Q++LR+
Sbjct: 604 REEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRR 649
Score = 94.4 bits (233), Expect = 3e-19
Identities = 78/262 (29%), Positives = 142/262 (54%), Gaps = 28/262 (10%)
Query: 287 NRTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSL----HKDLKQKRREQREQRERRRAA 342
++ + + R+R+ T + A++ Q + L ++L+++ RE+R ++E+ R
Sbjct: 871 DQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQY 930
Query: 343 KEEELLRLQQ---LQEEKE-RKLQELELL----QEAQRQAERLLQEEEERRRSQHRELQQ 394
+EEE L+ ++ L+EE+E R+ QE E ++ Q++ E+LL EE E+RR Q RE +
Sbjct: 931 REEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKY 990
Query: 395 ALEGQLREAEQARASMQAEMELKEEEAARQRQ----RIKELEEMQQRLQEALQLEVKARR 450
E +L++ E E L+EE R+RQ + ++ +E+QQ ++ L+ E + RR
Sbjct: 991 REEEELQQEE--------EQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRR 1042
Query: 451 DEESVR--IAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQA 508
+E R + L +EEE+ L + + + QE +ER +++EELQQE Q R +
Sbjct: 1043 LQERERQYREEEELQQEEEQLLGEERETRRRQE--LERQYRKEEELQQEEEQLLREEPEK 1100
Query: 509 QQQLEEVRQNRQRADEDVEAAQ 530
+++ E RQ R+ + E Q
Sbjct: 1101 RRRQERERQCREEEELQQEEEQ 1122
Score = 94.0 bits (232), Expect = 4e-19
Identities = 75/240 (31%), Positives = 134/240 (55%), Gaps = 24/240 (10%)
Query: 313 LQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQE----EKERKLQELELLQ 368
LQ E + + ++ RRE++E+ ++++ + E+ LR +Q +E ++ER+ Q+ Q
Sbjct: 271 LQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQ 330
Query: 369 EAQRQAERLLQEEEERRRSQHRELQQA--LEGQLR-EAEQARASMQ--AEMELKEEEAAR 423
+ +R+ ++L +E+EERR Q R Q+ E QLR E E+ R Q E +L+ E+ R
Sbjct: 331 QEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLR 390
Query: 424 QRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERY 483
+ Q+++ E Q R ++ L+ E + RR+++ R Q R E+EEE+ +Q K EQER
Sbjct: 391 REQQLR--REQQLRREQQLRREQQLRREQQLRREQQLR-REQEEERHEQ----KHEQERR 443
Query: 484 IERAQQEKEEL--------QQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQ 535
+R ++E+EE + E +Q R QQ ++ EE R+ R E+ E +++ R+
Sbjct: 444 EQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERR 503
Score = 94.0 bits (232), Expect = 4e-19
Identities = 89/349 (25%), Positives = 159/349 (45%), Gaps = 47/349 (13%)
Query: 296 DTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQR------EQRERRRAAKEEELLR 349
+ +R+ W + R Q E + + +++RREQR E+R ++R E++L R
Sbjct: 481 EEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRR 540
Query: 350 LQQ------LQEEKERKLQELELLQEAQRQAER-----LLQEEEERRRSQHRELQQALEG 398
Q+ L+ E+E++L++ Q +R+ E L +EEE R++ RE ++ LE
Sbjct: 541 EQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQ 600
Query: 399 QLR--EAEQARASMQAEMELKEEEAARQ-RQRIKELEEMQQRLQEALQLEVKARRDEESV 455
+L+ E E+ + E LK EE + RQ++ + EE ++R Q+ L+ E + RR++
Sbjct: 601 RLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLK 660
Query: 456 RIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQ--------QSRSLQQ 507
R EEEEE+L+Q ++ + E+ER + +E++E +E + Q S
Sbjct: 661 R-------EEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEAD 713
Query: 508 AQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRLMHPIEPGDKRPVT---- 563
A+Q R +Q + + K R+ + ++ W + E +R T
Sbjct: 714 ARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQ-WQEEERAHRQQQEEEQRRDFTWQWQ 772
Query: 564 --SSSFSGFQ-----PPLLAHRDSSLKRLTRWGSQGNRTPSPNSNEQQK 605
S G Q PPL R+ L+ R + P EQ++
Sbjct: 773 AEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRR 821
Score = 93.6 bits (231), Expect = 5e-19
Identities = 74/258 (28%), Positives = 140/258 (54%), Gaps = 21/258 (8%)
Query: 291 EMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQR----EQRERRRAAKEEE 346
++ + + +E+ Q+ R E + ++ +Q+RRE++ ++ E + K E
Sbjct: 192 QLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRET 251
Query: 347 LLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQA 406
+LR ++E KLQE +E QRQ E L +EEE+ R+ + +EL++ E Q E +Q
Sbjct: 252 VLR------KEEEKLQE----EEPQRQRE-LQEEEEQLRKLERQELRR--ERQEEEQQQQ 298
Query: 407 RASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEE 466
R + ++ K+EE R++Q + E+ ++R Q+ + E + RR++E R Q R +EE
Sbjct: 299 RLRREQQLRRKQEEERREQQE-ERREQQERREQQEERREQQLRREQEERREQQLRREQEE 357
Query: 467 EEKLKQLMQLKEEQ--ERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADE 524
E + +QL + +EE+ E+ + R QQ + E Q QQ R QQ +++ +++R+ +Q E
Sbjct: 358 ERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRRE-QQLRREQQLRRE 416
Query: 525 DVEAAQRKLRQASTNVKH 542
+++LR+ +H
Sbjct: 417 QQLRREQQLRREQEEERH 434
Score = 92.8 bits (229), Expect = 8e-19
Identities = 67/253 (26%), Positives = 134/253 (52%), Gaps = 25/253 (9%)
Query: 289 TYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELL 348
T++ A + +R + + +R Q E +Q R E+R+QRE+R +EEE
Sbjct: 768 TWQWQAEEKSERGRQRLSARPPLREQRE---------RQLRAEERQQREQRFLPEEEEKE 818
Query: 349 RLQQLQEEKERKLQELELLQEAQRQ--AERL------LQEEEERRRSQHRELQQALEGQL 400
+ ++ + E+E++LQ LE ++ QR+ A++L LQE++ERRRSQ + Q QL
Sbjct: 819 QRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQL 878
Query: 401 REAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQT 460
E + R +E+ +++Q ++E EE QR + K RR E+ + +
Sbjct: 879 EEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREERE-----KRRRQEQERQYREE 933
Query: 461 RLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQ 520
L++EEE QL++ + E+ R ER +Q +++ + + ++ ++ +++ + R+ +
Sbjct: 934 EQLQQEEE---QLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKY 990
Query: 521 RADEDVEAAQRKL 533
R +E+++ + +L
Sbjct: 991 REEEELQQEEEQL 1003
Score = 92.4 bits (228), Expect = 1e-18
Identities = 92/357 (25%), Positives = 152/357 (42%), Gaps = 59/357 (16%)
Query: 288 RTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQR---EQRERR-RAAK 343
R E R R E + R + K K L+Q+RREQR EQ ERR + K
Sbjct: 521 RQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLK 580
Query: 344 EEELLRLQQLQEEKERKLQ------ELELLQEAQRQAERLLQEEEERRRSQH----RELQ 393
EE R Q+L+ E+E +L+ E+E L++ +R+ +RL +EE E R Q E +
Sbjct: 581 REEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQE 640
Query: 394 QALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEE 453
+ + QLR +Q R + + +EEE R QR+K E ++R QE + E + R+
Sbjct: 641 ERRQQQLRREQQERREQRLK---REEEEERLEQRLKREHEEERREQELAEEEQEQARERI 697
Query: 454 SVRI--------------------------AQTRLLEEEEEKLKQLMQLKEEQERYIERA 487
RI Q R E+EE++ ++ +L+ ++E R
Sbjct: 698 KSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQ 757
Query: 488 QQEKEELQ--------QEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKL------ 533
QQE+E+ + +E +++ R A+ L E R+ + RA+E + QR L
Sbjct: 758 QQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEK 817
Query: 534 --RQASTNVKHWNVQMNRLMHPIEPGDKRPVTSSSFSGFQPPLLAHRDSSLKRLTRW 588
R+ + +Q ++ ++ G Q R +R +W
Sbjct: 818 EQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKW 874
Score = 92.4 bits (228), Expect = 1e-18
Identities = 84/272 (30%), Positives = 134/272 (49%), Gaps = 48/272 (17%)
Query: 312 RLQAEGKTSLHKDLKQKRREQ--REQRERRRAAKEEELLR----LQQLQEE------KER 359
R Q + + ++ Q+ EQ RE+RE+RR + E R LQQ +E+ ++R
Sbjct: 922 RRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKR 981
Query: 360 KLQELELL----QEAQRQAERLLQEEEERRRSQH--------RELQQALEGQLREAEQAR 407
+ QE E +E Q++ E+LL+EE E+RR Q ELQQ E LRE + R
Sbjct: 982 RRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKR 1041
Query: 408 ASMQAEMELKEEEAARQRQ-----------RIKELEEMQQRLQEALQLEVKARRDEESVR 456
+ E + +EEE +Q + R +ELE ++ +E Q E + R+E R
Sbjct: 1042 RLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKR 1101
Query: 457 IAQTR---LLEEEEEKLKQLMQLKEEQER----YIERAQQEKEELQQEMAQ------QSR 503
Q R EEEE + ++ L+EE+E+ +ER +E+EE+QQE Q + R
Sbjct: 1102 RRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKR 1161
Query: 504 SLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQ 535
Q+ ++Q E + +Q ++ + Q K RQ
Sbjct: 1162 RRQELERQYREEEELQQEEEQLLREEQEKRRQ 1193
Score = 91.7 bits (226), Expect = 2e-18
Identities = 69/245 (28%), Positives = 138/245 (56%), Gaps = 12/245 (4%)
Query: 298 RQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQ-QLQEE 356
RQR+E +Q + + + L+++ +E +ERRR+ ++ + + QL+EE
Sbjct: 822 RQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEE 881
Query: 357 KERKLQEL---ELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAE 413
++R+ L LQE R+ ++LLQEEEE + + RE ++ E + + E+ + + E
Sbjct: 882 RKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEE 941
Query: 414 MELKEEEAARQRQ----RIKELEEMQQRLQEALQLE-VKARRDEESVRIAQTRLLEEEEE 468
L+EE R+RQ + ++ +++QQ+ ++ L E K RR E + + L++EEE
Sbjct: 942 QLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEE 1001
Query: 469 KLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEA 528
+L + + K ++ + ER ++K+ELQQE Q R ++ +++L+E R+ + R +E+++
Sbjct: 1002 QLLREEREKRRRQEW-ERQYRKKDELQQEEEQLLRE-EREKRRLQE-RERQYREEEELQQ 1058
Query: 529 AQRKL 533
+ +L
Sbjct: 1059 EEEQL 1063
Score = 90.9 bits (224), Expect = 3e-18
Identities = 75/267 (28%), Positives = 143/267 (53%), Gaps = 32/267 (11%)
Query: 296 DTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQE 355
+ R+ QE + +L+ E K H + +++ ++E++ +EEE L+ ++ +E
Sbjct: 861 ERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREE-RE 919
Query: 356 EKERKLQELELLQE--AQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAE 413
++ R+ QE + +E Q++ E+LL+EE E+RR Q RE Q + +L++ E+ + E
Sbjct: 920 KRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPE 979
Query: 414 MELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTR-LLEEEEEKL-- 470
++E + ++ +E EE+QQ ++ L+ E + RR +E R + + L++EEE+L
Sbjct: 980 KRRRQE----REKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLR 1035
Query: 471 ----KQLMQLKEEQERYIERAQQEKEEL---------QQEMAQQSRSLQQAQQQLEEV-- 515
K+ +Q +E Q R E QQE+E+L +QE+ +Q R ++ QQ+ E++
Sbjct: 1036 EEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLR 1095
Query: 516 -------RQNRQRADEDVEAAQRKLRQ 535
RQ R+R + E Q++ Q
Sbjct: 1096 EEPEKRRRQERERQCREEEELQQEEEQ 1122
Score = 89.4 bits (220), Expect = 9e-18
Identities = 75/246 (30%), Positives = 129/246 (52%), Gaps = 26/246 (10%)
Query: 312 RLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQ 371
R + +GK SL +D +Q+ +QR R R +EE R +Q ++E+ER+L E E E
Sbjct: 100 RARCDGKESLLQDRRQE-EDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGE---EQS 155
Query: 372 RQAERLLQEEEERRRS----QHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQ- 426
+ ERL Q + +RR Q +E Q+ E + E + E +EE R+R+
Sbjct: 156 EKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRREL 215
Query: 427 ---RIKELEEMQQRLQEA-----LQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKE 478
R K EE QQ+ +E + E K R E+V + L+EEE + ++ +Q +E
Sbjct: 216 LELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEE 275
Query: 479 EQERYIE----RAQQEKEELQQEMAQQSRSLQQAQ-----QQLEEVRQNRQRADEDVEAA 529
EQ R +E R ++++EE QQ+ ++ + L++ Q +Q EE R+ ++R ++ E
Sbjct: 276 EQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERR 335
Query: 530 QRKLRQ 535
+++LR+
Sbjct: 336 EQQLRR 341
Score = 89.4 bits (220), Expect = 9e-18
Identities = 76/277 (27%), Positives = 142/277 (51%), Gaps = 30/277 (10%)
Query: 275 DGKRCMFCVKTANRTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQR- 333
DGK + ++ + + + R RQ Q + + E + L + +Q +++R
Sbjct: 104 DGKESL--LQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERL 161
Query: 334 EQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHREL- 392
EQR+R+R ++EEL R +Q +E+E + E E LQ + +EE+ RR + EL
Sbjct: 162 EQRDRQR--RDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELR 219
Query: 393 --------QQALEGQLR--EAEQARASMQAEMELKEEEAARQR---QRIKELEEMQQRLQ 439
QQ E Q R + E+ + + E L++EE Q QR +EL+E +++L+
Sbjct: 220 RKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLR 279
Query: 440 EALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMA 499
+ + E++ R EE E+++++L++ QL+ +QE Q+E+ E Q+
Sbjct: 280 KLERQELRRERQEE----------EQQQQRLRREQQLRRKQEEERREQQEERREQQERRE 329
Query: 500 QQ-SRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQ 535
QQ R QQ +++ EE R+ + R +++ E +++LR+
Sbjct: 330 QQEERREQQLRREQEERREQQLRREQEEERREQQLRR 366
Score = 89.4 bits (220), Expect = 9e-18
Identities = 76/278 (27%), Positives = 147/278 (52%), Gaps = 24/278 (8%)
Query: 273 DRDGKRCMFCVKTANRTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQ 332
+++ +R + + E + R ++E ++ + E + K +++R EQ
Sbjct: 541 EQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQ 600
Query: 333 REQRERRRAAKEEEL--LRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERR--RSQ 388
R +RE ++EE RL++ + E+ER+ Q L+ ++ +R+ ++L +E++ERR R +
Sbjct: 601 RLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLK 660
Query: 389 HRELQQALEGQL-REAEQARASMQAEMELKEEEAARQRQRIK-ELEEMQQRLQ---EALQ 443
E ++ LE +L RE E+ R E EL EEE + R+RIK + + Q +L+ +A Q
Sbjct: 661 REEEEERLEQRLKREHEEER----REQELAEEEQEQARERIKSRIPKWQWQLESEADARQ 716
Query: 444 LEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQ-------- 495
+V +R ++ Q R E+EE++ ++ +L+ ++E R QQE+E+ +
Sbjct: 717 SKVYSRPRKQE---GQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQA 773
Query: 496 QEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKL 533
+E +++ R A+ L E R+ + RA+E + QR L
Sbjct: 774 EEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFL 811
Score = 87.8 bits (216), Expect = 3e-17
Identities = 77/247 (31%), Positives = 134/247 (54%), Gaps = 29/247 (11%)
Query: 311 IRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELL---RLQQLQEEKERKLQELELL 367
+R Q +G+ K L++++R +R++RER+ +E++L R QQL+++++RK +E E
Sbjct: 1367 LRHQEQGR----KFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQ- 1421
Query: 368 QEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAA---RQ 424
Q ++++ +R +EEE++ R Q RE + E Q E+ R + E L+E E RQ
Sbjct: 1422 QLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQ 1481
Query: 425 RQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLK----EEQ 480
+ K LEE QQ ++ + + K R E + + + LEEE++ +Q Q K E+Q
Sbjct: 1482 ERDRKFLEEEQQLRRQ--ERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQ 1539
Query: 481 ERYIERAQQ----------EKEELQQEMAQQSRSLQQAQQ--QLEEVRQNRQRADEDVEA 528
R ER QQ E+E+L+QE +Q S Q+ + +LEE + RQ +
Sbjct: 1540 LRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFME 1599
Query: 529 AQRKLRQ 535
+++LR+
Sbjct: 1600 DEQQLRR 1606
Score = 87.8 bits (216), Expect = 3e-17
Identities = 76/255 (29%), Positives = 133/255 (52%), Gaps = 31/255 (12%)
Query: 308 QMAIRLQAEGKTSLHKDLKQKRREQ---REQRERRRAAKEEELLRL---QQLQEEKERKL 361
Q +R + + K + L Q+R EQ R++R+R+ +E +L R QQL+ +++RK
Sbjct: 1610 QQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKF 1669
Query: 362 QELE-LLQEAQRQA------ERLLQEEEERRRSQHRE---LQQALEGQLREAE---QARA 408
+E E LLQE + Q +R +EEE++ R Q RE LQ+ E QLR E + R
Sbjct: 1670 REEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQE--EQQLRRQELERKFRE 1727
Query: 409 SMQAEMELKEEEAARQRQRIKELEEMQ---QRLQEALQLEVKARRDEESVRIAQTR---- 461
Q E ++E+ RQ + K LEE Q +R ++ L+ + + R+ E ++ Q R
Sbjct: 1728 EEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQ 1787
Query: 462 -LLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQ 520
+E + K ++ QL++E+E R QQ + + E ++ L++ +Q+L + R +
Sbjct: 1788 LRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWE--EEQLQLEEQEQRLRQERDRQY 1845
Query: 521 RADEDVEAAQRKLRQ 535
RA+E ++ R+
Sbjct: 1846 RAEEQFATQEKSRRE 1860
Score = 87.4 bits (215), Expect = 4e-17
Identities = 71/253 (28%), Positives = 129/253 (50%), Gaps = 24/253 (9%)
Query: 296 DTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQ--REQRERRRAAKEEELLRLQQL 353
+ R+RQE + LQ E + L ++ +++RR++ R+ RE +EEE L ++
Sbjct: 1099 EKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEP 1158
Query: 354 Q----EEKERKLQELELLQEAQRQAERLLQEEEERRRS-------QHRELQQALEGQLRE 402
+ +E ER+ +E E E Q++ E+LL+EE+E+RR + ELQ+ Q
Sbjct: 1159 EKRRRQELERQYREEE---ELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYR 1215
Query: 403 AEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRL 462
E R+ ++ + E ++E A R + + E +Q QLE RD +S + Q L
Sbjct: 1216 DEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQ----FRQLEDSQLRDRQSQQDLQHLL 1271
Query: 463 LEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRA 522
E++E +Q + ++++R+ +Q + E Q+E ++ R Q+ +Q L E R+ ++R
Sbjct: 1272 GEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRR 1331
Query: 523 DEDVEAAQRKLRQ 535
E RK R+
Sbjct: 1332 QE----TDRKFRE 1340
Score = 87.4 bits (215), Expect = 4e-17
Identities = 67/235 (28%), Positives = 122/235 (51%), Gaps = 24/235 (10%)
Query: 323 KDLKQKRREQREQRERRRAAKEEELLRLQQ-----LQEEKERKLQELELLQEAQRQAERL 377
+D K + E R Q + R+ +EE+ LR Q+ L+EE++ + QE E Q+ ++ +R
Sbjct: 1358 RDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQERE--QQLRQDRDRK 1415
Query: 378 LQEEEERRRSQHRELQ-QALEGQLREAEQARASMQAEMELKEEEAAR---QRQRIKELEE 433
+EEE++ Q R+ + + E Q+R E+ R ++ E +L++E + + Q ++E EE
Sbjct: 1416 FREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREE 1475
Query: 434 MQQRLQEA----LQLEVKARRDEESVRIAQTRL---------LEEEEEKLKQLMQLKEEQ 480
Q QE L+ E + RR E + + L LEEE++ +Q Q K Q
Sbjct: 1476 QQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQ 1535
Query: 481 ERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQ 535
E R Q+ ++ +Q+ ++ R +Q +Q+ EE + +RQ D ++K+R+
Sbjct: 1536 EEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRR 1590
Score = 85.1 bits (209), Expect = 2e-16
Identities = 61/229 (26%), Positives = 119/229 (51%), Gaps = 11/229 (4%)
Query: 312 RLQAEGKTSLHKDLKQKRREQ---REQRERRRAAKEEELLRLQQLQEEKERKLQELELLQ 368
R + K + L+Q+R EQ R++R+R+ +E+++ R +E+ERK E E
Sbjct: 1550 RQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRR-----QEQERKFMEDEQQL 1604
Query: 369 EAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQ--RQ 426
Q ++L QE + + R + LQ+ E QL E+ R ++ E +L+ +E +Q
Sbjct: 1605 RRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHD 1664
Query: 427 RIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIER 486
R ++ E +Q LQE + +++ + + R + +L +E E+ K L + ++ + + +ER
Sbjct: 1665 RDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERER-KFLQEEQQLRRQELER 1723
Query: 487 AQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQ 535
+E+E+L+QE Q+ Q+ +++ E Q R +E Q + R+
Sbjct: 1724 KFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRK 1772
Score = 84.3 bits (207), Expect = 3e-16
Identities = 73/264 (27%), Positives = 129/264 (48%), Gaps = 36/264 (13%)
Query: 288 RTYEMSASDTRQRQEWTAAIQMAIRLQAE---GKTSLHKDLKQKRREQREQRERR--RAA 342
R E +RQE +Q +R + + + + L ++ E+R ++ERR R
Sbjct: 509 REQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLK 568
Query: 343 KEEELLRLQQLQEEKERKLQELELLQE-------AQRQAERLLQEEEERRRSQHRELQQA 395
+E+E R Q L+ E+ER+ Q L+ QE + + ERL QEE +R + E ++
Sbjct: 569 REQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEE 628
Query: 396 LEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESV 455
QL ++E+ Q +L+ E+ R+ QR+K EE ++RL++ L+ E + R E+
Sbjct: 629 RRQQLLKSEEQEERRQ--QQLRREQQERREQRLKR-EEEEERLEQRLKREHEEERREQ-- 683
Query: 456 RIAQTRLLEEEEEKLKQLM---------QLKEEQER-----YIERAQQEKEELQQEMAQQ 501
L EEE+E+ ++ + QL+ E + Y +QE + +QE ++
Sbjct: 684 -----ELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEK 738
Query: 502 SRSLQQAQQQLEEVRQNRQRADED 525
R + Q EE R +RQ+ +E+
Sbjct: 739 RRRRESELQWQEEERAHRQQQEEE 762
Score = 84.3 bits (207), Expect = 3e-16
Identities = 66/236 (27%), Positives = 123/236 (52%), Gaps = 32/236 (13%)
Query: 327 QKRREQREQRERRRAAKEEELLRL---QQLQEEKERKLQELE-LLQEAQRQA------ER 376
++++ +R+++ER+ E++L R QQL++E++RK +E E LLQE + Q +R
Sbjct: 1584 EEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDR 1643
Query: 377 LLQEEEERRRSQHRE-----------------LQQALEGQLREAEQARASMQAEMELKEE 419
EEE + R Q RE LQ+ E QLR E+ R + E +L+ +
Sbjct: 1644 KFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQ 1703
Query: 420 EAAR---QRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQL 476
E R Q ++ +E++++ +E QL + +++ + ++LEEE+ + ++ Q
Sbjct: 1704 ERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQ 1763
Query: 477 KEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRK 532
QER +R +E+E+L+QE +Q Q++ ++ E Q RQ +E Q++
Sbjct: 1764 LRRQER--DRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQR 1817
Score = 83.2 bits (204), Expect = 7e-16
Identities = 69/256 (26%), Positives = 131/256 (51%), Gaps = 33/256 (12%)
Query: 308 QMAIRLQAEGKTSLHKDLKQKRREQ---REQRERRRAAKEEEL--------LRLQQLQ-E 355
+ +R + K + L Q+R EQ R++R+R+ +E++L R Q+L+ +
Sbjct: 1452 EQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQ 1511
Query: 356 EKERK-LQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEM 414
E ERK L+E + L QRQ + L +E++ RR+ + ++ +Q + + RE EQ R + +
Sbjct: 1512 EPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQ 1571
Query: 415 ----------ELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLE 464
L+E++ RQ Q K +E+ QQ ++ Q +++ RD + Q LL+
Sbjct: 1572 LSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQ--LLQ 1629
Query: 465 EEEEKLKQLMQLKEEQERYIE-----RAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNR 519
E EE Q + +E +++E R Q+ +++L+ + ++ R +Q Q+ EE + R
Sbjct: 1630 EREE---QQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRR 1686
Query: 520 QRADEDVEAAQRKLRQ 535
Q D +++LR+
Sbjct: 1687 QERDRKFREEEQQLRR 1702
Score = 82.8 bits (203), Expect = 9e-16
Identities = 75/233 (32%), Positives = 119/233 (51%), Gaps = 30/233 (12%)
Query: 316 EGKTSLHKDLKQKRREQREQ---RERRRAAKEEELLRLQQLQEEKERKL--QELELLQEA 370
E + L +D +K RE+ +Q +ER R +EEE Q ++E+ERK +E +L QE
Sbjct: 1403 EREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQ---QVRRQERERKFLEEEQQLRQER 1459
Query: 371 QR---QAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQR 427
R + E+LLQE EE++ + ++ LE + + Q R E EL+ +E R+
Sbjct: 1460 HRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLE 1519
Query: 428 IKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQ------- 480
++ QQR ++ LQ E + RR E + Q R + EE +QL Q +EEQ
Sbjct: 1520 EEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREE--EQLRQEREEQQLSRQER 1577
Query: 481 -------ERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDV 526
E+ + R +QE++ ++ E QQ R Q+ QQQL + R + R DE +
Sbjct: 1578 DRKFRLEEQKVRRQEQERKFMEDE--QQLRR-QEGQQQLRQERDRKFREDEQL 1627
Score = 82.8 bits (203), Expect = 9e-16
Identities = 72/218 (33%), Positives = 120/218 (55%), Gaps = 29/218 (13%)
Query: 316 EGKTSLHKDLKQKRREQREQRERR----RAAKEEELLRLQQLQEEKERKLQELELLQEAQ 371
E + L + ++++ Q EQ+ RR R +EEE LR + QE+ R+ + ++L+E Q
Sbjct: 1695 EEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQ 1754
Query: 372 RQAERLLQEEEERRRSQHRELQQALEGQLREA--EQARASMQAEMELKEEEAARQRQRIK 429
+ ER EE++ R Q R+ + E QLR+ EQ S +++ + +EEE RQ
Sbjct: 1755 LRPER----EEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQ----- 1805
Query: 430 ELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLK---EEQERYIER 486
E EE Q R Q Q + K R +EE ++ LEE+E++L+Q + EEQ E+
Sbjct: 1806 EREEQQLRPQ---QRDGKYRWEEEQLQ------LEEQEQRLRQERDRQYRAEEQFATQEK 1856
Query: 487 AQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADE 524
+++E++EL QE Q+ R Q+ +++L E RQ+ +E
Sbjct: 1857 SRREEQELWQEEEQKRR--QERERKLREEHIRRQQKEE 1892
Score = 82.4 bits (202), Expect = 1e-15
Identities = 66/243 (27%), Positives = 126/243 (51%), Gaps = 19/243 (7%)
Query: 316 EGKTSLHKDLKQKRREQREQRERR-----RAAKEEELLRLQQLQEEK--ERKLQELELLQ 368
+ + L L +++ REQ RR R EEE L ++ +E K +RK QE + L
Sbjct: 1262 QSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLL 1321
Query: 369 EAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEE--EAARQRQ 426
+R+ +R QE + + R + + LQ+ E LR E+ R + E+ +E+ + + Q
Sbjct: 1322 REEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQ 1381
Query: 427 RIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKE--EQERYI 484
R++ E ++ L+E QL + R E+ +R + R EEE++L + + ++ E+E+ +
Sbjct: 1382 RLRRQERERKFLKEEQQLRCQER--EQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQV 1439
Query: 485 ERAQ------QEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQAST 538
R + +E+++L+QE ++ R +Q Q+ EE + +RQ D +++LR+
Sbjct: 1440 RRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQER 1499
Query: 539 NVK 541
+ K
Sbjct: 1500 DRK 1502
Score = 82.4 bits (202), Expect = 1e-15
Identities = 64/220 (29%), Positives = 119/220 (54%), Gaps = 24/220 (10%)
Query: 328 KRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRS 387
+R EQ+E + R R ++EE+ Q L+EE+E K + E ++ R+ E+LLQE EE+
Sbjct: 1300 EREEQKEAKRRDRKSQEEK----QLLREEREEKRRRQETDRKF-REEEQLLQEREEQPLR 1354
Query: 388 QHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEM--QQRLQEALQLE 445
+ ++ E +LR EQ R ++ E L+ +E R+R+ +KE +++ Q+R Q+ Q
Sbjct: 1355 RQERDRKFREEELRHQEQGRKFLEEEQRLRRQE--RERKFLKEEQQLRCQEREQQLRQDR 1412
Query: 446 VKARRDEESV--RIAQTRLLEEEEEK----------LKQLMQLKEEQERYI---ERAQQE 490
+ R+EE R + R EEE++ L++ QL++E+ R E+ QE
Sbjct: 1413 DRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQE 1472
Query: 491 KEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQ 530
+EE Q ++ R + +QQL ++R+ ++++ + +
Sbjct: 1473 REEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQE 1512
Score = 81.3 bits (199), Expect = 3e-15
Identities = 67/240 (27%), Positives = 130/240 (54%), Gaps = 23/240 (9%)
Query: 316 EGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELE-LLQEAQRQA 374
E + L + + ++ + EQ+ RR+ + + L QQL++E+ RK +E E LLQE + Q
Sbjct: 1418 EEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQ 1477
Query: 375 ------ERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRI 428
+R EEE++ R Q R+ ++ E +LR E R ++ E +L ++ RQR+ +
Sbjct: 1478 LHRQERDRKFLEEEQQLRRQERD-RKFREQELRSQEPERKFLEEEQQLHRQQ--RQRKFL 1534
Query: 429 KELEEM--QQRLQEALQLEVKARRDEESVRIA---QTRLLEEEEEKLK---QLMQLKEEQ 480
+E +++ Q+R Q+ Q + R+EE +R Q +E + K + Q ++ +E++
Sbjct: 1535 QEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQE 1594
Query: 481 ERYIE-----RAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQ 535
+++E R Q+ +++L+QE ++ R +Q Q+ EE + +RQ D + +LR+
Sbjct: 1595 RKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRR 1654
Score = 80.5 bits (197), Expect = 4e-15
Identities = 65/248 (26%), Positives = 125/248 (50%), Gaps = 28/248 (11%)
Query: 325 LKQKRREQREQRERRRAAKEEELL----RLQQLQ-EEKERKLQELELLQEAQRQAERLLQ 379
L+++ REQ+ + +R R +EEE L QQL+ +E++RK +E E Q + + LQ
Sbjct: 1652 LRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQ 1711
Query: 380 EEEERRRSQ-------HRELQQALEG-QLREAEQARASMQAEM--ELKEEEAARQRQRIK 429
EE++ RR + +L+Q E QLR E+ R ++ E +EE+ R+++R +
Sbjct: 1712 EEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDR 1771
Query: 430 ELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLK------------QLMQLK 477
+ E +Q QE + +++++ + R + E EE++L+ + +QL
Sbjct: 1772 KFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQL- 1830
Query: 478 EEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQAS 537
EEQE+ + + + + +++ A Q +S ++ Q+ +E Q R++ E + RQ
Sbjct: 1831 EEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQK 1890
Query: 538 TNVKHWNV 545
+H V
Sbjct: 1891 EEQRHRQV 1898
Score = 80.1 bits (196), Expect = 6e-15
Identities = 77/280 (27%), Positives = 138/280 (49%), Gaps = 30/280 (10%)
Query: 299 QRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKE 358
+ QE Q+ Q + L ++ +++R EQR +RE +E+EL +Q Q +
Sbjct: 637 EEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARER 696
Query: 359 RKLQ----ELELLQEAQ-RQAE---RLLQEEEERRRSQHRELQQALEGQLREAEQARASM 410
K + + +L EA RQ++ R ++E +RRR + E ++ E +L+ E+ RA
Sbjct: 697 IKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHR 756
Query: 411 QAEMELK----------EEEAARQRQRIKELEEMQQRLQEALQLEVKARRDE----ESVR 456
Q + E + EE++ R RQR+ ++++ + L+ E + +R++ E
Sbjct: 757 QQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEE 816
Query: 457 IAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEE---LQQEM----AQQSRSLQQAQ 509
Q R E EK Q ++ +EEQ + ERAQQ +EE LQ++ +Q+ R Q+ +
Sbjct: 817 KEQRRRQRREREKELQFLE-EEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWR 875
Query: 510 QQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNR 549
QLEE R+ R+ A Q +LR+ ++ ++ R
Sbjct: 876 WQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQR 915
Score = 77.8 bits (190), Expect = 3e-14
Identities = 73/277 (26%), Positives = 126/277 (45%), Gaps = 69/277 (24%)
Query: 326 KQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQA----------- 374
+Q RREQ+E+RE+R +EEE Q+L+ E E + +E EL +E Q QA
Sbjct: 645 QQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKW 704
Query: 375 ------------------------ERLLQEEEERRRSQHRELQ----QALEGQLREAEQA 406
+R QE+EE+RR + ELQ + Q +E EQ
Sbjct: 705 QWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQR 764
Query: 407 R------------------------ASMQAEMELKEEEAARQRQR-IKELEEMQQRLQEA 441
R Q E +L+ EE ++ QR + E EE +QR ++
Sbjct: 765 RDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQR 824
Query: 442 LQLEVKAR---RDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEM 498
+ E + + +E+ R + + L+EEE+ L++ + + QE+ R Q+ + +L++E
Sbjct: 825 REREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQ--RRDQKWRWQLEEER 882
Query: 499 AQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQ 535
++ +L E++R+ +Q E+ E QR+ R+
Sbjct: 883 KRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREERE 919
Score = 77.4 bits (189), Expect = 4e-14
Identities = 82/316 (25%), Positives = 149/316 (47%), Gaps = 48/316 (15%)
Query: 273 DRDGKRCMFCVKTANRTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQ 332
+++ +R + R + + +R E + RL+ E + ++ + KR E
Sbjct: 570 EQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEER----REQRLKREEP 625
Query: 333 REQRERRRAAKEEELLRLQQ--LQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHR 390
E+R ++ EE+ R QQ +E++ER+ Q L+ +E +R +RL +E EE RR Q
Sbjct: 626 EEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQ-- 683
Query: 391 ELQQALEGQLREAEQARASMQAEMELKEEEAARQ------------RQRIKELEEMQQRL 438
EL + + Q RE ++R + + +L+ E ARQ ++R +E EE ++R
Sbjct: 684 ELAEEEQEQARERIKSRIP-KWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRR 742
Query: 439 QEALQLEVKARRDEESVRIAQTR------LLEEEEEKLKQLMQ----LKEEQERYI---E 485
+ LQ + + R + Q R EE+ E+ +Q + L+E++ER + E
Sbjct: 743 ESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEE 802
Query: 486 RAQQEKEELQQEMAQQSRSLQQAQQQL-------EEVRQNRQRA-----DED--VEAAQR 531
R Q+E+ L +E ++ R Q+ +++ EE Q R+RA +ED E +R
Sbjct: 803 RQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQER 862
Query: 532 KLRQASTNVKHWNVQM 547
+ Q + W Q+
Sbjct: 863 RRSQEQRRDQKWRWQL 878
Score = 77.0 bits (188), Expect = 5e-14
Identities = 60/235 (25%), Positives = 129/235 (54%), Gaps = 25/235 (10%)
Query: 323 KDLKQKRREQREQRERRRAAKEEELLRL---QQLQEEKERKLQELELLQEAQRQAERLLQ 379
K L+++++ R+QR+R+ +E++L R QQ +++++RK +E E L++ +R+ ++L +
Sbjct: 1516 KFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQ-EREEQQLSR 1574
Query: 380 EEEER--RRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQR---QRIKELEEM 434
+E +R R + + +Q E + E EQ + + +L++E + R Q ++E EE
Sbjct: 1575 QERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQ 1634
Query: 435 QQRLQEA----LQLEVKARRDEESVRIAQTR----------LLEEEEEKLKQLMQLKE-- 478
Q QE L+ E + RR E ++ R L E EE++L++ + ++
Sbjct: 1635 QLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFR 1694
Query: 479 EQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKL 533
E+E+ + R ++E++ LQ+E + + L++ ++ E++RQ ++ + RK+
Sbjct: 1695 EEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKI 1749
Score = 75.9 bits (185), Expect = 1e-13
Identities = 64/210 (30%), Positives = 107/210 (50%), Gaps = 29/210 (13%)
Query: 353 LQEEKERKLQELELLQEAQRQAE---------RLLQEEEERRRSQHRELQ--QALEGQLR 401
L EEK + E L + +RQ E R L+EE +RR Q R+ Q + EG+ +
Sbjct: 95 LDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQ 154
Query: 402 EAEQARASMQAEMELKEEEAARQRQRIKELEEM---QQRLQEALQLEVKARRDEESVRIA 458
+Q R Q + + ++EE RQRQ +E EE +++LQ E + DEE +R
Sbjct: 155 SEKQERLE-QRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRR 213
Query: 459 QTRLLEEEEEKLKQLMQLKEEQERYIERAQQ------------EKEELQQEMAQQSRSLQ 506
+ L + + KQ Q +E Q+R + ++ E+E+LQ+E Q+ R LQ
Sbjct: 214 ELLELRRKGREEKQ-QQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQ 272
Query: 507 QAQQQLEEV-RQNRQRADEDVEAAQRKLRQ 535
+ ++QL ++ RQ +R ++ E Q++LR+
Sbjct: 273 EEEEQLRKLERQELRRERQEEEQQQQRLRR 302
Score = 74.7 bits (182), Expect = 2e-13
Identities = 80/289 (27%), Positives = 136/289 (47%), Gaps = 42/289 (14%)
Query: 288 RTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKR-REQREQRERRRAAKEEE 346
R E++ + Q +E + + Q E + + R R+Q QR RR+ +E+
Sbjct: 681 REQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQR-RRQEQEEKR 739
Query: 347 LLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHR-----ELQQALEGQLR 401
R +LQ ++E + + +E +R Q EE+ R + R L++ E QLR
Sbjct: 740 RRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLR 799
Query: 402 --EAEQARASMQAEMELKEEEAARQRQRIKELE-----------EMQQRLQE---ALQLE 445
E +Q E E KE+ ++R+R KEL+ E Q+LQE LQ +
Sbjct: 800 AEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQED 859
Query: 446 VKARRDEESVRIAQTR-LLEEE--------------EEKLKQLMQLKEEQERYIERAQQE 490
+ RR +E R + R LEEE +E+L++ QL +E+E ++R ++E
Sbjct: 860 QERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREERE 919
Query: 491 KEELQQEMAQ--QSRSLQQAQQQ-LEEVRQNRQRADEDVE-AAQRKLRQ 535
K Q++ Q + LQQ ++Q L E R+ R+R + + + +KL+Q
Sbjct: 920 KRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQ 968
Score = 74.7 bits (182), Expect = 2e-13
Identities = 60/195 (30%), Positives = 105/195 (53%), Gaps = 17/195 (8%)
Query: 308 QMAIRLQAEGKTSLHKDLKQK-RREQREQRERRRAAKEEELLR----LQQL-QEEKERKL 361
Q R + E K + L+Q+ +EQ ++ER R EEE LR QQL ++E++RK
Sbjct: 1714 QQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKF 1773
Query: 362 QELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEA 421
+E E L++ + + + QE + + R + + Q+ E QLR ++ E +L+ EE
Sbjct: 1774 REEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEE- 1832
Query: 422 ARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQE 481
Q QR+++ + Q R +E + K+RR+E+ L +EEE+K +Q + K +E
Sbjct: 1833 --QEQRLRQERDRQYRAEEQFATQEKSRREEQ-------ELWQEEEQKRRQERERKLREE 1883
Query: 482 RYIERAQQEKEELQQ 496
+I R Q+E++ +Q
Sbjct: 1884 -HIRRQQKEEQRHRQ 1897
Score = 74.3 bits (181), Expect = 3e-13
Identities = 61/229 (26%), Positives = 117/229 (51%), Gaps = 21/229 (9%)
Query: 326 KQKRREQREQRER-----RRAAKEEELLRLQQLQE---EKERKLQELELLQEAQRQAERL 377
+++ R+ REQ R R+ +EE+ L QQ Q ++E++L+ E Q+ ++ +R
Sbjct: 1497 QERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRK 1556
Query: 378 LQEEEERRRS--------QHRELQQALEGQ-LREAEQARASMQAEMELKEEEAARQ--RQ 426
+EEE+ R+ Q R+ + LE Q +R EQ R M+ E +L+ +E +Q ++
Sbjct: 1557 FREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQE 1616
Query: 427 RIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIER 486
R ++ E +Q LQE + E + R E + + +E+ +QL ++ + R E+
Sbjct: 1617 RDRKFREDEQLLQE--REEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQ 1674
Query: 487 AQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQ 535
QE EE Q ++ R ++ +QQL + R+ E+ + +++L +
Sbjct: 1675 LLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELER 1723
Score = 72.8 bits (177), Expect = 9e-13
Identities = 75/292 (25%), Positives = 139/292 (47%), Gaps = 56/292 (19%)
Query: 296 DTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQ---- 351
+ R+RQE + LQ E + L ++ ++KRR++RE R +EEE L+ Q
Sbjct: 1159 EKRRRQELERQYREEEELQQEEEQLLREE-QEKRRQERE-----RQYREEEELQRQKRKQ 1212
Query: 352 -------------QLQEEKE------------------RKLQELELL-QEAQRQAERLLQ 379
Q + EKE R+L++ +L +++Q+ + LL
Sbjct: 1213 RYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLG 1272
Query: 380 EEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQ 439
E++ER R Q R Q + E EQ Q E + ++ ++ ++Q ++E E ++R Q
Sbjct: 1273 EQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQ 1332
Query: 440 EA-----LQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKE--EQERYIERAQQEKE 492
E + ++ R+E+ +R Q R + EE+L+ Q ++ E+E+ + R ++E++
Sbjct: 1333 ETDRKFREEEQLLQEREEQPLR-RQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERK 1391
Query: 493 ELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQ---RKLRQASTNVK 541
L++E Q Q+ +QQL + R + R +E + Q RK R+ V+
Sbjct: 1392 FLKEE---QQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVR 1440
Score = 66.2 bits (160), Expect = 8e-11
Identities = 60/229 (26%), Positives = 108/229 (47%), Gaps = 25/229 (10%)
Query: 323 KDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEE 382
K + ++ Q E + R +++L L Q+E++R+ + Q + E E E
Sbjct: 1243 KGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLERE 1302
Query: 383 ERRRSQHRELQQALEGQL--REAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQE 440
E++ ++ R+ + E QL E E+ R + + + +EEE Q ++E EE R QE
Sbjct: 1303 EQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEE-----QLLQEREEQPLRRQE 1357
Query: 441 ALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQ----LKEEQE-RYIERAQQ------ 489
+ R+EE Q R EEE++L++ + LKEEQ+ R ER QQ
Sbjct: 1358 ----RDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRD 1413
Query: 490 ---EKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQ 535
+EE Q ++ R ++ +QQ+ + R+ +E+ + Q + R+
Sbjct: 1414 RKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRK 1462
Score = 45.1 bits (105), Expect = 2e-04
Identities = 57/238 (23%), Positives = 109/238 (45%), Gaps = 40/238 (16%)
Query: 208 EVYQELIQDVLKQGYLWKRGHLRRNWAERWFQLQPSCLCYFGSEECKEK---RGIIPLDA 264
E Q+L + ++ +L + LRR ER F+ + E+ + + R I+ +
Sbjct: 1695 EEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEE- 1753
Query: 265 HCCVEVLPDRDGKRCMFCVKTANRTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKD 324
++ P+R+ ++ + E R+ Q+ +R Q + ++
Sbjct: 1754 ----QLRPEREEQQLRRQERDRKFREEEQLRQEREEQQ--------LRSQESDRKFREEE 1801
Query: 325 LKQKRREQREQRERRRAAK---EEELLRL----QQLQEEKERKLQELELL---QEAQRQA 374
++ RE+++ R ++R K EEE L+L Q+L++E++R+ + E ++++R+
Sbjct: 1802 QLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREE 1861
Query: 375 ERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELE 432
+ L QEEE++RR Q E +LRE R + KEE+ RQ IK E
Sbjct: 1862 QELWQEEEQKRR-------QERERKLREEHIRR-------QQKEEQRHRQVGEIKSQE 1905
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 98.2 bits (243), Expect = 2e-20
Identities = 58/237 (24%), Positives = 127/237 (53%), Gaps = 6/237 (2%)
Query: 314 QAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQ 373
Q E K ++ Q+R E+ +++E + +EE++ R +++ EKE K++ E + + +
Sbjct: 285 QQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE 344
Query: 374 AERLLQE---EEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKE 430
R L+E E+E+ R Q + Q+ E ++RE E+ R +A+M +EE+ Q ++I+E
Sbjct: 345 KIRELEEKMHEQEKIREQEEKRQE--EEKIREQEK-RQEQEAKMWRQEEKIREQEEKIRE 401
Query: 431 LEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQE 490
EEM Q +E + + + ++E Q + +EEK+++ + EQE I ++
Sbjct: 402 QEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEM 461
Query: 491 KEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQM 547
+E +++M +Q + + + +++E + +R +E + ++K+R+ ++ M
Sbjct: 462 MQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMM 518
Score = 98.2 bits (243), Expect = 2e-20
Identities = 52/217 (23%), Positives = 122/217 (56%), Gaps = 5/217 (2%)
Query: 323 KDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKL----QELELLQEAQRQAERLL 378
++L++K EQ + RE+ +EEE +R Q+ ++E+E K+ +++ +E R+ E ++
Sbjct: 347 RELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMM 406
Query: 379 QEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRL 438
QE+EE+ Q ++ + E +++E E+ + ++ +E++ Q ++I+E EEM Q
Sbjct: 407 QEQEEKMGEQEEKMWEQ-EEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQ 465
Query: 439 QEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEM 498
+E + + ++E+ Q + +EEK+++ + EQE I ++ +E +++M
Sbjct: 466 EEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKM 525
Query: 499 AQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQ 535
+Q + + +++++E + +R +E + + +LRQ
Sbjct: 526 WEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQ 562
Score = 95.5 bits (236), Expect = 1e-19
Identities = 67/289 (23%), Positives = 150/289 (51%), Gaps = 17/289 (5%)
Query: 283 VKTANRTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLK------QKRREQREQR 336
V++ +++ + +++ E + +LQAE L K+L+ Q + E+ E
Sbjct: 221 VESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEAD-HLGKELQSVSAKLQAQVEENELW 279
Query: 337 ERRRAAKEEELLRLQQLQEEKERKLQELE----LLQEAQRQAERLLQEEEERRRSQHREL 392
R +EE++ R ++ +E+E K+QE E +E R+ E ++ E+EE+ R Q E+
Sbjct: 280 NRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQ-EEM 338
Query: 393 QQALEGQLREAEQARASMQAEMELKEEEAARQ-RQRIKELEEMQQRLQEALQLEVKARRD 451
E ++RE E+ M + +++E+E RQ ++I+E E+ Q++ + + E K R
Sbjct: 339 MWEKEEKIRELEE---KMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQ 395
Query: 452 EESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQ 511
EE +R Q +++E+EEK+ + + EQE ++ +++ ++++ +Q + +++ +++
Sbjct: 396 EEKIR-EQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEK 454
Query: 512 LEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRLMHPIEPGDKR 560
+ E + Q +E + + K+ + ++ +M R I +K+
Sbjct: 455 IREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKK 503
Score = 90.5 bits (223), Expect = 4e-18
Identities = 60/272 (22%), Positives = 142/272 (52%), Gaps = 24/272 (8%)
Query: 298 RQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQ----- 352
++R+E + IR Q E K +++ ++ E+ ++E KEE++ L++
Sbjct: 298 QEREEKIQEQEEKIREQEE-KMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQ 356
Query: 353 --LQEEKERKLQELELLQEAQRQ--------AERLLQEEEERRRSQHRELQQALEGQLRE 402
++E++E++ +E ++ ++ +RQ E ++E+EE+ R Q E+ Q E ++ E
Sbjct: 357 EKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQ-EEMMQEQEEKMGE 415
Query: 403 AEQARASMQAEMELKEEEAARQRQRIKELE----EMQQRL---QEALQLEVKARRDEESV 455
E+ + EM+ +EE+ RQ ++I+E E E ++++ +E +Q + + ++E
Sbjct: 416 QEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGK 475
Query: 456 RIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEV 515
Q ++E+EEK+++ + EQE+ I +++ E ++ M +Q + + ++++ E
Sbjct: 476 MCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQ 535
Query: 516 RQNRQRADEDVEAAQRKLRQASTNVKHWNVQM 547
+ Q +E + + K+R+ ++ +M
Sbjct: 536 EEKMQEQEEKMRRQEEKMREQEVRLRQQEEKM 567
Score = 89.4 bits (220), Expect = 9e-18
Identities = 58/225 (25%), Positives = 123/225 (54%), Gaps = 19/225 (8%)
Query: 308 QMAIRLQAEGKTSLHKDLKQKRREQRE----QRERRRAAKEEELLRLQQLQEEKERKLQE 363
Q IR Q E + K +Q++R+++E ++E + +EE++ +++ +E+E K+ E
Sbjct: 356 QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGE 415
Query: 364 LELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAAR 423
E E + E +QE+EE+ R Q ++++ E ++RE E+ + M+ +EE+
Sbjct: 416 QE---EKMWEQEEEMQEQEEKMRRQEEKIREQ-EKKIREQEEKIREQEEMMQEQEEKMGE 471
Query: 424 QRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERY 483
Q ++ E E Q +E K RR EE +R Q + + E+EEK+++ ++ +EQE
Sbjct: 472 QEGKMCEQEAKMQEQEE------KMRRQEEKIR-EQEKKIREQEEKIREQEEMMQEQEEK 524
Query: 484 IERAQQEKEELQQEMAQQSRSLQQAQQQLEE----VRQNRQRADE 524
+ +++ E +++M +Q +++ ++++ E +RQ ++ E
Sbjct: 525 MWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQE 569
Score = 84.3 bits (207), Expect = 3e-16
Identities = 57/227 (25%), Positives = 119/227 (52%), Gaps = 23/227 (10%)
Query: 288 RTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEEL 347
R E + +RQE Q A + E K ++ +++ E +++E + +EE++
Sbjct: 366 RQEEEKIREQEKRQE-----QEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKM 420
Query: 348 LRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQAR 407
++ +E+E K++ E E R+ E+ ++E+EE+ R Q E+ Q E ++ E E
Sbjct: 421 WEQEEEMQEQEEKMRRQE---EKIREQEKKIREQEEKIREQ-EEMMQEQEEKMGEQEGKM 476
Query: 408 ASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEE 467
+A+M+ +EE+ RQ ++I+E E+ K R EE +R Q +++E+E
Sbjct: 477 CEQEAKMQEQEEKMRRQEEKIREQEK-------------KIREQEEKIR-EQEEMMQEQE 522
Query: 468 EKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEE 514
EK+ + + EQE ++ +++ +++M +Q L+Q +++++E
Sbjct: 523 EKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQE 569
Score = 64.7 bits (156), Expect = 2e-10
Identities = 60/240 (25%), Positives = 118/240 (49%), Gaps = 27/240 (11%)
Query: 327 QKRREQR--EQRERRRAAKEEELLRLQQLQEE---KERKLQELELLQEAQRQAERLLQEE 381
QK++ R E+ + R A EL R EE K KLQE L E+++ +L +E
Sbjct: 175 QKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKE 234
Query: 382 EERRRSQHREL--QQALEGQL----REAEQARASMQAEMELKEEEAARQRQRIKELEEMQ 435
+R+ + + L QQ L+ + +E + A +QA++E E +Q+ +++ +
Sbjct: 235 LKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQE 294
Query: 436 QRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQ 495
+++QE E K + EE +R + ++ +EE +M KEE+ R E EKEE
Sbjct: 295 EKIQER---EEKIQEQEEKIREQEEKMRRQEE-----MMWEKEEKMRRQEEMMWEKEEKI 346
Query: 496 QEMAQQS------RSLQQAQQQLEEVRQNRQRADEDVE--AAQRKLRQASTNVKHWNVQM 547
+E+ ++ R ++ +Q+ E++R+ +R +++ + + K+R+ ++ M
Sbjct: 347 RELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMM 406
Score = 52.8 bits (125), Expect = 1e-06
Identities = 51/231 (22%), Positives = 101/231 (43%), Gaps = 12/231 (5%)
Query: 326 KQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERR 385
+QK Q ++ RR + + +R+ Q K L Q A +Q E ++ R
Sbjct: 98 EQKASHQHQEALRRELEAQVQTIRILTCQ--KTELQMALYYSQHAVKQLEGEARDLISRL 155
Query: 386 RSQHR---ELQQALEG---QLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQ 439
+ EL+QAL Q ++A++ + E + E R +EL+E +LQ
Sbjct: 156 HDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQ 215
Query: 440 EALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMA 499
E LQL V++ + E + + + + E + L QL+ E + + Q +LQ ++
Sbjct: 216 EKLQL-VESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVE 274
Query: 500 QQ---SRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQM 547
+ +R QQ ++++ + Q +E ++ + K+R+ ++ M
Sbjct: 275 ENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMM 325
Score = 37.4 bits (85), Expect = 0.042
Identities = 40/148 (27%), Positives = 71/148 (47%), Gaps = 17/148 (11%)
Query: 404 EQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEAL--------QLEVKARRDEESV 455
++ +AS Q + L+ E A Q Q I+ L + LQ AL QLE +AR D S
Sbjct: 97 DEQKASHQHQEALRRELEA-QVQTIRILTCQKTELQMALYYSQHAVKQLEGEAR-DLISR 154
Query: 456 RIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQ-------A 508
+ E E+ L + K++ +RYIE +E++ L E+ + + + ++
Sbjct: 155 LHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKL 214
Query: 509 QQQLEEVRQNRQRADEDVEAAQRKLRQA 536
Q++L+ V + +V+ +RKL +A
Sbjct: 215 QEKLQLVESEKSEIQLNVKELKRKLERA 242
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 96.3 bits (238), Expect = 8e-20
Identities = 80/296 (27%), Positives = 149/296 (50%), Gaps = 23/296 (7%)
Query: 288 RTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEEL 347
RT+ + + T+A + ++ + T L D K+K R++ E R+ +E E
Sbjct: 493 RTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRK---EEAEQ 549
Query: 348 LRLQQLQEEKERKLQELELLQEAQ-----RQAERLLQEEEERRRSQHRELQQ-------A 395
LR Q+++E+K R+L+E++L +E + + ER+ Q +EE+++ ++ Q A
Sbjct: 550 LRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKA 609
Query: 396 LEGQLREAEQARASMQAEME-----LKEEEAARQRQRIKELEEMQQRLQEALQLEVKARR 450
E +L E + + + +ME K+EE AR R R + EE ++R QE LQ + K
Sbjct: 610 KEERLAEEKAKKKAAAKKMEEVEARRKQEEEAR-RLRWLQQEEEERRHQELLQKK-KEEE 667
Query: 451 DEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQ 510
E + A+ + L E+ E+ ++ + +E++ R ER +QE+ E ++++A+Q R +Q +
Sbjct: 668 QERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERL 727
Query: 511 QLEEVRQNRQRADE-DVEAAQRKLRQASTNVKHWNVQMNRLMHPIEPGDKRPVTSS 565
Q E Q R++A E QR+L + + + +L E K +S
Sbjct: 728 QAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGAS 783
Score = 90.1 bits (222), Expect = 5e-18
Identities = 74/213 (34%), Positives = 118/213 (55%), Gaps = 24/213 (11%)
Query: 313 LQAEGKTSLHKDLKQKRREQREQR--ERRRAAKEEELLRLQQLQEEKERKLQELELLQEA 370
LQA + K+ K+K+ EQ+ + E+ AKEE L + ++ +K++E+E ++
Sbjct: 578 LQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQ 637
Query: 371 QRQAERL--LQEEEERRRSQHRELQQALEGQLRE-----AEQARASMQAEMELKEEEAAR 423
+ +A RL LQ+EEE RR H+EL Q + + +E AE R + Q E E +E+E
Sbjct: 638 EEEARRLRWLQQEEEERR--HQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERRE 695
Query: 424 QRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLK-QLMQL------ 476
Q +R +E E ++R QE E + RR++E R+ R L+E E+ L+ Q QL
Sbjct: 696 QERREQERREQERREQERQLAEQERRREQE--RLQAERELQEREKALRLQKEQLQRELEE 753
Query: 477 ---KEEQERYIER-AQQEKEELQQEMAQQSRSL 505
KEEQ+R ER Q+E+E+ +E A S++L
Sbjct: 754 KKKKEEQQRLAERQLQEEQEKKAKEAAGASKAL 786
Score = 48.9 bits (115), Expect = 1e-05
Identities = 39/142 (27%), Positives = 69/142 (48%), Gaps = 24/142 (16%)
Query: 312 RLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQ 371
R + E + ++ +++ +E+REQ +QL E++ R+ QE +
Sbjct: 688 RREQERREQERREQERREQERREQE--------------RQLAEQERRREQE-------R 726
Query: 372 RQAERLLQEEEERRRSQHRELQQALEGQLREAEQARAS---MQAEMELKEEEAARQRQRI 428
QAER LQE E+ R Q +LQ+ LE + ++ EQ R + +Q E E K +EAA + +
Sbjct: 727 LQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKAL 786
Query: 429 KELEEMQQRLQEALQLEVKARR 450
++Q + Q+ + R
Sbjct: 787 NVTVDVQSPACTSYQMTPQGHR 808
>gi|221139761 zinc finger protein 853 [Homo sapiens]
Length = 659
Score = 95.5 bits (236), Expect = 1e-19
Identities = 74/257 (28%), Positives = 149/257 (57%), Gaps = 16/257 (6%)
Query: 298 RQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEK 357
+Q+Q +Q RLQ + + L Q+++ ++Q + ++ +E++LL+ QQ Q ++
Sbjct: 155 QQQQLQPQQVQEQQRLQQQ-QEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQ 213
Query: 358 ERKLQELELLQEAQ--RQAERLLQEEEERRRSQHRELQQAL----EGQLREA--EQARAS 409
++ LQ+ E LQ+ Q +Q E+L Q+++ Q +LQQ L + QL++ EQ +A
Sbjct: 214 QQLLQQQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQ 273
Query: 410 MQAEMELKEEEAARQRQRIKELEEMQQRL-QEALQLEVKARRDEESVRIAQTRL-LEEEE 467
+Q ++ L+++E +Q+Q+ + L++ Q++L Q+ LQ +EE V + + L E+
Sbjct: 274 LQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQ 333
Query: 468 EKLKQLMQLKEEQERYIERAQQEKE---ELQQEMAQQSRSLQQAQQQLEEVRQNRQRADE 524
E +Q +L+ +QE +ER Q++++ +LQ+E+ Q + L+Q QQQLE+ +
Sbjct: 334 ELEQQRQELERQQE--LERQQEQRQLQLKLQEELQQLEQQLEQQQQQLEQQEVQLELTPV 391
Query: 525 DVEAAQRKLRQASTNVK 541
++ A Q++++ T V+
Sbjct: 392 ELGAQQQEVQLELTPVQ 408
Score = 91.7 bits (226), Expect = 2e-18
Identities = 73/300 (24%), Positives = 159/300 (53%), Gaps = 31/300 (10%)
Query: 299 QRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQE--- 355
Q+Q Q +LQ E S+H + + Q+++ + + +E RLQQ QE
Sbjct: 119 QQQPQQDGQQQLSQLQQEKHQSVHHQELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQ 178
Query: 356 ----EKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQ 411
++++ LQ+ E LQ+ ++ + L Q++E+ ++ Q + Q+ L+ Q + +Q + Q
Sbjct: 179 TQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQLQQQ 238
Query: 412 AEMELKEEEAARQRQRIKELE-EMQQRL----QEALQLEVKARRDEESVRIAQTRLLEEE 466
++ L +++ Q+Q +++ + ++QQ+L Q LQ ++ ++ E+ + Q +LL+++
Sbjct: 239 QQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQ 298
Query: 467 EEKLKQLMQLKEEQERYIERAQQEKEEL---------QQEMAQQSRSLQQAQQQLEEVRQ 517
+E+L+Q ++ Q +E ++E+ EL +QE+ QQ + L++ QQ+LE ++
Sbjct: 299 QEQLQQ----QQLQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQELER-QQELERQQE 353
Query: 518 NRQ---RADEDVEAAQRKLRQASTNVKHWNVQMNRLMHPIEPGDKRPVTSSSFSGFQPPL 574
RQ + E+++ +++L Q ++ VQ+ + P+E G ++ + QP L
Sbjct: 354 QRQLQLKLQEELQQLEQQLEQQQQQLEQQEVQLE--LTPVELGAQQQEVQLELTPVQPEL 411
Score = 75.9 bits (185), Expect = 1e-13
Identities = 66/252 (26%), Positives = 133/252 (52%), Gaps = 31/252 (12%)
Query: 334 EQRERRRAAKEEELLRLQQLQEEKERKLQ-ELELLQEAQRQAERLLQEEEERRRSQHREL 392
E E R + E L+LQQL+++ E + Q + E LQ+ Q E L Q+ ++ + Q +L
Sbjct: 77 EIAEETRPGQRE--LQLQQLEQQPEPQQQPQHEQLQQPQPHLE-LQQQPQQDGQQQLSQL 133
Query: 393 QQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQR-----LQEALQLEVK 447
QQ + E ++ E++L ++ Q Q+++E + +QQ+ Q+A + +V
Sbjct: 134 QQEKHQSVHHQE-----LKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVL 188
Query: 448 ARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQE----MAQQSR 503
++++ ++ + +LL++++E+L+Q L+++++ ++ QQ++E+LQQ+ + QQ
Sbjct: 189 QQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQLQQQQQLLLLQQQG 248
Query: 504 SLQQA---------QQQLEEVRQ---NRQRADEDVEAAQRKLRQASTNVKHWNVQMNRLM 551
LQQ QQQL E +Q +Q + E Q++ +Q + +Q +L
Sbjct: 249 QLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQ 308
Query: 552 -HPIEPGDKRPV 562
P+EP ++ V
Sbjct: 309 PPPLEPEEEEEV 320
Score = 73.6 bits (179), Expect = 5e-13
Identities = 64/234 (27%), Positives = 122/234 (52%), Gaps = 29/234 (12%)
Query: 298 RQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKR----REQREQRERRRAAKEEELLRLQQL 353
+Q QE Q +LQ + + L+Q++ +EQ +Q+++ +++ L+ Q L
Sbjct: 196 QQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLL 255
Query: 354 QEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAE------QAR 407
Q+++ + Q+L Q+AQ Q + LLQ++E+ ++ Q ++L Q + QL++ + +
Sbjct: 256 QQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEPE 315
Query: 408 ASMQAEMEL------KEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTR 461
+ E+EL E+E +QRQ ++ +E++ R QE QL++K + +
Sbjct: 316 EEEEVELELMPVDLGSEQELEQQRQELERQQELE-RQQEQRQLQLKLQEE---------- 364
Query: 462 LLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEV 515
L++ E++L+Q Q E+QE +E E QQE+ Q + Q + QLE V
Sbjct: 365 -LQQLEQQLEQQQQQLEQQEVQLELTPVELGAQQQEV-QLELTPVQPELQLELV 416
Score = 60.1 bits (144), Expect = 6e-09
Identities = 47/186 (25%), Positives = 92/186 (49%), Gaps = 23/186 (12%)
Query: 379 QEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRL 438
+E +ER S R A G AE+ R Q E++L++ E + Q+ + E++QQ
Sbjct: 55 EEPQERNSSPQRPAVSAPVGASEIAEETRPG-QRELQLQQLEQQPEPQQQPQHEQLQQP- 112
Query: 439 QEALQLEVKARRDEESVRIAQTRLLEEEEEK---------------LKQLMQLKEEQERY 483
Q L+L+ + ++D Q +L + ++EK + Q QL+ +Q +
Sbjct: 113 QPHLELQQQPQQD------GQQQLSQLQQEKHQSVHHQELKPELQLMHQQQQLQPQQVQE 166
Query: 484 IERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHW 543
+R QQ++E+LQ + AQ+ + LQQ +Q ++V++ + + + Q++L Q ++
Sbjct: 167 QQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQ 226
Query: 544 NVQMNR 549
Q +
Sbjct: 227 QFQQQQ 232
Score = 54.7 bits (130), Expect = 3e-07
Identities = 54/205 (26%), Positives = 96/205 (46%), Gaps = 32/205 (15%)
Query: 291 EMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQR--ERRRAAKEEELL 348
++ +Q+QE Q + LQ +G+ L + L Q+++ Q +Q+ E+++A +++LL
Sbjct: 222 QLQQQQFQQQQEQLQQQQQLLLLQQQGQ--LQQQLLQQQQAQLQQQLLEQQQAQLQQQLL 279
Query: 349 R--------------LQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQ 394
LQQ QE+ LQ+ Q Q L EEEE EL
Sbjct: 280 LQQQEQLQQQQQQQLLQQQQEQ----------LQQQQLQPPPLEPEEEE---EVELELMP 326
Query: 395 ALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEES 454
G +E EQ R ++ + EL+ ++ RQ Q +K EE+QQ Q+ Q + + + E
Sbjct: 327 VDLGSEQELEQQRQELERQQELERQQEQRQLQ-LKLQEELQQLEQQLEQQQQQLEQQEVQ 385
Query: 455 VRIAQTRLLEEEEEKLKQLMQLKEE 479
+ + L +++E +L ++ E
Sbjct: 386 LELTPVELGAQQQEVQLELTPVQPE 410
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 95.5 bits (236), Expect = 1e-19
Identities = 73/294 (24%), Positives = 148/294 (50%), Gaps = 47/294 (15%)
Query: 301 QEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQ-----REQRERRRAA----KEEELLRLQ 351
QEW IQ E + + + ++ RR++ +E++ RR+ KEE++ R +
Sbjct: 371 QEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQE 430
Query: 352 QLQEEKERKLQELELL---QEAQRQAERLLQEEEERRRSQHRELQQA----LEGQLREAE 404
++ EKE K++ELE QE R+ E QEEE+ R + R+ Q+A E ++RE E
Sbjct: 431 EMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQE 490
Query: 405 QARASMQAEM------------------ELKEEEAARQRQRIKELEEMQQRLQEALQLEV 446
+ + +M ++EE RQ ++I+E EE+ ++ ++ + E
Sbjct: 491 EKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEE 550
Query: 447 KAR-------RDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQ--QEKEELQQE 497
K R R EE + + ++ E+EE+ +Q +++E++E+ E+ + +E+EE+ QE
Sbjct: 551 KIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQE 610
Query: 498 ----MAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQM 547
M +Q + + +++++E + +R +E + ++K+R+ ++ M
Sbjct: 611 QEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMM 664
Score = 89.4 bits (220), Expect = 9e-18
Identities = 55/213 (25%), Positives = 120/213 (56%), Gaps = 7/213 (3%)
Query: 326 KQKRREQREQ-RERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEER 384
++KR+EQ E R+ + ++EE+ R ++ E+E K+++ E ++ RQ E++ +EE+
Sbjct: 516 EEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQE--EKMWRQEEKMHDQEEKI 573
Query: 385 RRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQ- 443
R + + +Q E ++RE E+ + ++ +EE Q +++ E EE +E +Q
Sbjct: 574 REQEEKVWRQ--EEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQE 631
Query: 444 LEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSR 503
E K RR EE +R Q + + E+EEK+++ ++ +EQE + +++ E +++M +Q
Sbjct: 632 QEEKMRRQEEKIR-EQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEE 690
Query: 504 SLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQA 536
+++ ++++ E ++ +E ++ Q L A
Sbjct: 691 KMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAA 723
Score = 87.0 bits (214), Expect = 5e-17
Identities = 60/225 (26%), Positives = 124/225 (55%), Gaps = 16/225 (7%)
Query: 326 KQKRREQREQRERRRAAKEEELLRLQQL----QEEKERKLQEL--ELLQEAQRQAERLLQ 379
K R+E++ Q + ++EE +R Q+ QEEK R+ +E+ E ++ +RQ E + +
Sbjct: 362 KMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE 421
Query: 380 EEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQ-RQRIKELEEMQQRL 438
+EE+ RR + E+ E ++RE E+ M + +++E+E RQ ++I+E E+ Q++
Sbjct: 422 KEEKMRRQE--EMMWEKEEKIRELEE---KMHEQEKIREQEEKRQEEEKIREQEKRQEQE 476
Query: 439 QEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIER---AQQEKEELQ 495
+ + E K R EE +R Q + +EEK+ + +++EE++R + Q+EK Q
Sbjct: 477 AKMWRQEEKIREQEEKIR-EQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQ 535
Query: 496 QEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNV 540
+E+ +Q + + ++++ + + R +E + + K+R+ V
Sbjct: 536 EEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKV 580
Score = 86.3 bits (212), Expect = 8e-17
Identities = 60/257 (23%), Positives = 130/257 (50%), Gaps = 33/257 (12%)
Query: 323 KDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEE 382
++L++K EQ + RE+ +EEE +R Q+ ++E+E K+ E E R+ E ++E+E
Sbjct: 441 RELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQE---EKIREQEEKIREQE 497
Query: 383 ERRRSQHREL--QQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQE 440
E+ Q ++ Q+ + + + EQ Q E ++EE RQ+++I E EE ++ +E
Sbjct: 498 EKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEE 557
Query: 441 AL----------------------QLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKE 478
+ + E K R EE +R + ++ E+EE +Q ++ E
Sbjct: 558 KMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGE 617
Query: 479 EQERYIERAQ--QEKEE----LQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRK 532
++E+ E+ + QE+EE ++++ +Q + +++ ++++ E + Q +E + + K
Sbjct: 618 QEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEK 677
Query: 533 LRQASTNVKHWNVQMNR 549
+ + ++ +M R
Sbjct: 678 MCEQEEKMQEQEEKMRR 694
Score = 86.3 bits (212), Expect = 8e-17
Identities = 54/265 (20%), Positives = 134/265 (50%), Gaps = 10/265 (3%)
Query: 299 QRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKE 358
+RQE + R + E K ++ +++ E+ ++E + +EE++ ++++EE++
Sbjct: 459 KRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEK 518
Query: 359 RKLQELELLQEAQ--------RQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASM 410
R+ QE QE + RQ E++ ++EE+ R+ + + +Q E ++ + E+
Sbjct: 519 RQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQ--EEKMHDQEEKIREQ 576
Query: 411 QAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKL 470
+ ++ +EE+ Q ++I+E EE + +E Q + + ++E Q ++E+EEK+
Sbjct: 577 EEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKM 636
Query: 471 KQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQ 530
++ + EQE+ I +++ E ++ M +Q + + ++++ E + Q +E + +
Sbjct: 637 RRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQE 696
Query: 531 RKLRQASTNVKHWNVQMNRLMHPIE 555
K+ + ++ +M +E
Sbjct: 697 EKMWEQEVRLRQQEEKMQEHQEHLE 721
Score = 84.7 bits (208), Expect = 2e-16
Identities = 68/277 (24%), Positives = 141/277 (50%), Gaps = 19/277 (6%)
Query: 283 VKTANRTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLK------QKRREQREQR 336
V++ +++ + +++ E + +LQAE L K+L+ Q + E+ E
Sbjct: 294 VESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEAD-HLGKELQSVSAKLQAQVEENELW 352
Query: 337 ERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQAL 396
R +EE++ R ++ +E E K+QE E E R+ E ++E+EE+ R Q E+
Sbjct: 353 NRLNQQQEEKMWRQEEKIQEWEEKIQEQE---EKIREQEEKIREQEEKMRRQE-EMMWEK 408
Query: 397 EGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVR 456
E ++R E+ + +M +EE + ++I+ELEE QE ++ + + R++EE +R
Sbjct: 409 EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHE-QEKIREQEEKRQEEEKIR 467
Query: 457 IAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVR 516
Q + E+E + +Q +++E++E+ R Q+EK Q+E + +++ +++ E+
Sbjct: 468 -EQEKRQEQEAKMWRQEEKIREQEEKI--REQEEKMWRQEEKIHEQEKIREEEKRQEQEE 524
Query: 517 QNRQ----RADEDVEAAQRKLRQASTNVKHWNVQMNR 549
RQ R E++ + K+ + ++ +M R
Sbjct: 525 MWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWR 561
Score = 79.3 bits (194), Expect = 1e-14
Identities = 64/248 (25%), Positives = 134/248 (54%), Gaps = 26/248 (10%)
Query: 301 QEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERK 360
+E A +Q ++L K+ + ++K+ +R + + + LL QQLQ E +
Sbjct: 281 KEKNAKLQEKLQLVESEKSEIQLNVKELKR---------KLERAKLLLPQQQLQAEADHL 331
Query: 361 LQELELLQ-EAQRQAE------RLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAE 413
+EL+ + + Q Q E RL Q++EE+ Q ++Q+ E +++E E+ + +
Sbjct: 332 GKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQE-WEEKIQEQEEKIREQEEK 390
Query: 414 MELKEEEAARQRQRIKELEEMQQRLQEAL-QLEVKARRDEESV--RIAQTRLLEE---EE 467
+ +EE+ RQ + + E EE +R +E + + E K RR EE + + + R LEE E+
Sbjct: 391 IREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQ 450
Query: 468 EKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVE 527
EK+++ + ++E+E+ R Q++++E + +M +Q +++ ++++ E + R +E +
Sbjct: 451 EKIREQEEKRQEEEKI--REQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIH 508
Query: 528 AAQRKLRQ 535
Q K+R+
Sbjct: 509 -EQEKIRE 515
Score = 56.2 bits (134), Expect = 9e-08
Identities = 38/156 (24%), Positives = 82/156 (52%), Gaps = 12/156 (7%)
Query: 298 RQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEK 357
R+++E + IR Q E + ++++ +EQ E+ +E+ + +++QE++
Sbjct: 574 REQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQE 633
Query: 358 ERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELK 417
E+ ++ +E R+ E+ ++E+EE+ R Q E+ Q E ++ E E+ + +M+ +
Sbjct: 634 EKMRRQ----EEKIREQEKKIREQEEKIREQ-EEMMQEQEEKMWEQEEKMCEQEEKMQEQ 688
Query: 418 EEEAARQRQ-------RIKELEEMQQRLQEALQLEV 446
EE+ RQ + R+++ EE Q QE L+ +
Sbjct: 689 EEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAAI 724
Score = 48.5 bits (114), Expect = 2e-05
Identities = 70/281 (24%), Positives = 122/281 (43%), Gaps = 45/281 (16%)
Query: 291 EMSASDTRQ---RQEWTAAIQMAIRLQAEGKTSLHKDL-------KQKRREQREQRER-- 338
E AS Q R+E A + IR+ KT L L KQ E R+ R
Sbjct: 171 EQKASHQHQEALRRELEAQVH-TIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLH 229
Query: 339 ---RRAAKEEELLRLQQLQEEK-ERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQ 394
+ A + E+ L Q++K +R ++EL ++A L E R EL++
Sbjct: 230 DSWKFAGELEQALSAVATQKKKADRYIEELTKERDA-------LSLELYRNTITDEELKE 282
Query: 395 ALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEA------------- 441
+L+E Q S ++E++L +E R+ +R K L QQ EA
Sbjct: 283 K-NAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAK 341
Query: 442 LQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIE------RAQQEKEELQ 495
LQ +V+ + Q + +EEK+++ + +EQE I R Q+EK Q
Sbjct: 342 LQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQ 401
Query: 496 QEMA-QQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQ 535
+EM ++ +++ ++ + E + +R +E + + K+R+
Sbjct: 402 EEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRE 442
Score = 32.0 bits (71), Expect = 1.8
Identities = 40/154 (25%), Positives = 67/154 (43%), Gaps = 17/154 (11%)
Query: 404 EQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEAL--------QLEVKARRDEESV 455
++ +AS Q + L+ E A Q I+ L + LQ AL QLE +AR D S
Sbjct: 170 DEQKASHQHQEALRRELEA-QVHTIRILTCQKTELQMALYYSQHAVKQLEGEAR-DLISR 227
Query: 456 RIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEV 515
+ E E+ L + K++ +RYIE EL +E S L + EE+
Sbjct: 228 LHDSWKFAGELEQALSAVATQKKKADRYIE-------ELTKERDALSLELYRNTITDEEL 280
Query: 516 RQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNR 549
++ + E ++ + + + NVK ++ R
Sbjct: 281 KEKNAKLQEKLQLVESEKSEIQLNVKELKRKLER 314
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 94.7 bits (234), Expect = 2e-19
Identities = 67/260 (25%), Positives = 141/260 (54%), Gaps = 18/260 (6%)
Query: 288 RTYEMSASDTRQRQEWTAAI---QMAIRLQAEGKTSLHKDL---KQKRREQREQRERRRA 341
R E + +RQE A + + IR Q E K + ++K EQ + RE +
Sbjct: 399 RQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKR 458
Query: 342 AKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLR 401
++EE+ R QEEK R+ +E+ +E + E++ ++EE+ R + + Q E ++R
Sbjct: 459 QEQEEMWR----QEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQ--EEKIR 512
Query: 402 EAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTR 461
E E+ + ++ +EE+ Q ++I+E EEM Q +E + + + +++E +R + +
Sbjct: 513 EQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEK 572
Query: 462 LLEEEEEKLKQLMQLKEEQERYIERAQ--QEKEELQQE----MAQQSRSLQQAQQQLEEV 515
+ E+EE+ +Q +++E++E+ E+ + +E+EE+ QE M +Q + + +++++E
Sbjct: 573 IREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQ 632
Query: 516 RQNRQRADEDVEAAQRKLRQ 535
+ +R +E + + +LRQ
Sbjct: 633 EEKMRRQEEKMWEQEVRLRQ 652
Score = 92.4 bits (228), Expect = 1e-18
Identities = 69/281 (24%), Positives = 142/281 (50%), Gaps = 42/281 (14%)
Query: 301 QEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQ-----REQRERRRAA----KEEELLRLQ 351
QEW IQ E + + + ++ RR++ +E++ RR+ KEE++ RL+
Sbjct: 310 QEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLE 369
Query: 352 QLQEEKERKLQELELL---------QEAQRQAERLLQEEEERR-------------RSQH 389
++ EKE K++ELE QE +RQ E ++E+E+R+ R Q
Sbjct: 370 EMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQE 429
Query: 390 RELQQALEGQLREAEQARAS---MQAEMELKEEEAARQRQRIKELEEM---QQRLQEALQ 443
++++ + R+ E+ + E ++EE RQ ++I+E EE+ ++++ E +
Sbjct: 430 EKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEK 489
Query: 444 L---EVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQ 500
+ E K R EE + + ++ E+EE+ +Q +++E++E+ R Q+EK Q+EM Q
Sbjct: 490 IRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKI--REQEEKIREQEEMMQ 547
Query: 501 QSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVK 541
+ Q++ + ++ +R +E + + K+R+ ++
Sbjct: 548 EQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIR 588
Score = 87.0 bits (214), Expect = 5e-17
Identities = 53/214 (24%), Positives = 122/214 (57%), Gaps = 11/214 (5%)
Query: 326 KQKRREQREQ-RERRRAAKEEELLRLQQLQEEKERKLQELELL---QEAQRQAERLLQEE 381
++KR+EQ E R+ + ++EE+ R ++ E+E+ ++ E + +E E ++E+
Sbjct: 455 EEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQ 514
Query: 382 EERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEA 441
EE+ Q ++++ E ++RE E+ + M+ +EE+ Q ++++E E+M+++ ++
Sbjct: 515 EEKMWRQEEKIREQ-EEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKI 573
Query: 442 LQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIER-----AQQEK-EELQ 495
+ E K R +E +R + ++ E+EE+ +Q ++E++E+ E+ Q+EK +E +
Sbjct: 574 REQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQE 633
Query: 496 QEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAA 529
++M +Q + + + +L + + Q E +EAA
Sbjct: 634 EKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAA 667
Score = 82.4 bits (202), Expect = 1e-15
Identities = 60/220 (27%), Positives = 124/220 (56%), Gaps = 17/220 (7%)
Query: 326 KQKRREQREQRERRRAAKEEELLRLQQL----QEEKERKLQEL--ELLQEAQRQAERLLQ 379
K R+E++ Q + ++EE +R Q+ QEEK R+ +E+ E ++ +RQ E + +
Sbjct: 301 KMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE 360
Query: 380 EEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQ-RQRIKELEEMQQRL 438
+EE+ RR + E+ E ++RE E+ M + +++E+E RQ ++I+E E+ Q++
Sbjct: 361 KEEKMRRLE--EMMWEKEEKIRELEE---KMHEQEKIREQEEKRQEEEKIREQEKRQEQE 415
Query: 439 QEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIER---AQQEKEELQ 495
+ + E K R EE +R Q + + +EEK+ + +++EE++R + Q+EK Q
Sbjct: 416 AKMWRQEEKIREQEEKIR-EQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQ 474
Query: 496 QEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQ 535
+E+ +Q + + Q+++ + + R +E + + K+R+
Sbjct: 475 EEIWRQKEKMHE-QEKIRKQEEKVWRQEEKMHDQEEKIRE 513
Score = 80.1 bits (196), Expect = 6e-15
Identities = 65/263 (24%), Positives = 135/263 (51%), Gaps = 19/263 (7%)
Query: 283 VKTANRTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLK------QKRREQREQR 336
V++ +++ + +++ E + +LQAE L K+L+ Q + E+ E
Sbjct: 233 VESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEAD-HLGKELQSVSAKLQAQVEENELW 291
Query: 337 ERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQAL 396
R +EE++ R ++ +E E K+QE E E R+ E ++E+EE+ R Q E+
Sbjct: 292 NRLNQQQEEKMWRQEEKIQEWEEKIQEQE---EKIREQEEKIREQEEKMRRQ-EEMMWEK 347
Query: 397 EGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVR 456
E ++R E+ + +M EE + ++I+ELEE QE ++ + + R++EE +R
Sbjct: 348 EEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHE-QEKIREQEEKRQEEEKIR 406
Query: 457 IAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVR 516
Q + E+E + +Q +++E++E+ R Q++K Q+E + +++ +++ E+
Sbjct: 407 -EQEKRQEQEAKMWRQEEKIREQEEKI--REQEKKMWRQEEKIHEQEKIREEEKRQEQEE 463
Query: 517 QNRQ----RADEDVEAAQRKLRQ 535
RQ R E++ + K+ +
Sbjct: 464 MWRQEEKIREQEEIWRQKEKMHE 486
Score = 77.4 bits (189), Expect = 4e-14
Identities = 64/248 (25%), Positives = 134/248 (54%), Gaps = 26/248 (10%)
Query: 301 QEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERK 360
+E A +Q ++L K+ + ++K+ +R + + + LL QQLQ E +
Sbjct: 220 KEKNAKLQEKLQLVESEKSEIQLNVKELKR---------KLERAKLLLPQQQLQAEADHL 270
Query: 361 LQELELLQ-EAQRQAE------RLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAE 413
+EL+ + + Q Q E RL Q++EE+ Q ++Q+ E +++E E+ + +
Sbjct: 271 GKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQE-WEEKIQEQEEKIREQEEK 329
Query: 414 MELKEEEAARQRQRIKELEEMQQRLQEAL-QLEVKARRDEESV--RIAQTRLLEE---EE 467
+ +EE+ RQ + + E EE +R +E + + E K RR EE + + + R LEE E+
Sbjct: 330 IREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQ 389
Query: 468 EKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVE 527
EK+++ + ++E+E+ R Q++++E + +M +Q +++ ++++ E + R +E +
Sbjct: 390 EKIREQEEKRQEEEKI--REQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIH 447
Query: 528 AAQRKLRQ 535
Q K+R+
Sbjct: 448 -EQEKIRE 454
Score = 50.4 bits (119), Expect = 5e-06
Identities = 41/156 (26%), Positives = 79/156 (50%), Gaps = 20/156 (12%)
Query: 298 RQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEK 357
R+++E + IR Q E + + ++ + +EQ + RR +EE +R Q EEK
Sbjct: 526 REQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRR---QEEKIREQ---EEK 579
Query: 358 ERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELK 417
R+ +E + + Q E++ ++EE+ R + E+ Q E ++ E E+ + +M+ +
Sbjct: 580 IREQKE-----KIREQEEKIWEQEEKIR--EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQ 632
Query: 418 EEEAARQRQ-------RIKELEEMQQRLQEALQLEV 446
EE+ RQ + R+++ EE Q QE L+ +
Sbjct: 633 EEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAAI 668
Score = 48.5 bits (114), Expect = 2e-05
Identities = 70/281 (24%), Positives = 122/281 (43%), Gaps = 45/281 (16%)
Query: 291 EMSASDTRQ---RQEWTAAIQMAIRLQAEGKTSLHKDL-------KQKRREQREQRER-- 338
E AS Q R+E A + IR+ KT L L KQ E R+ R
Sbjct: 110 EQKASHQHQEALRRELEAQVH-TIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLH 168
Query: 339 ---RRAAKEEELLRLQQLQEEK-ERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQ 394
+ A + E+ L Q++K +R ++EL ++A L E R EL++
Sbjct: 169 DSWKFAGELEQALSAVATQKKKADRYIEELTKERDA-------LSLELYRNTITDEELKE 221
Query: 395 ALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEA------------- 441
+L+E Q S ++E++L +E R+ +R K L QQ EA
Sbjct: 222 K-NAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAK 280
Query: 442 LQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIE------RAQQEKEELQ 495
LQ +V+ + Q + +EEK+++ + +EQE I R Q+EK Q
Sbjct: 281 LQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQ 340
Query: 496 QEMA-QQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQ 535
+EM ++ +++ ++ + E + +R +E + + K+R+
Sbjct: 341 EEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRE 381
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 94.4 bits (233), Expect = 3e-19
Identities = 56/234 (23%), Positives = 126/234 (53%), Gaps = 16/234 (6%)
Query: 326 KQKRREQREQ-RERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEER 384
++KR+EQ E R+ + ++EE+ R ++ E+E K+++ E ++ RQ E++ ++EE+
Sbjct: 469 EEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQE--EKVWRQEEKIREQEEKI 526
Query: 385 RRSQHRELQQALEGQLREAEQA---RASMQAEMELKEEEAA--------RQRQRIKELEE 433
R + + +Q E ++RE E+ M + ++ EEE RQ ++I+E EE
Sbjct: 527 REQEEKMWRQ--EEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEE 584
Query: 434 MQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEE 493
R +E ++ + + R+++E Q + E+EEK+++ + EQE I ++ +E
Sbjct: 585 KVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQE 644
Query: 494 LQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQM 547
+++M +Q + + +++++E + R +E + ++K+R+ ++ M
Sbjct: 645 QEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMM 698
Score = 90.9 bits (224), Expect = 3e-18
Identities = 60/230 (26%), Positives = 128/230 (55%), Gaps = 14/230 (6%)
Query: 314 QAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELL----QE 369
Q E + ++++ + REQ E+ R +EE++ R +++ EKE K++ E + +E
Sbjct: 305 QEEKIQEWEEKIQEQEEKIREQEEKIRE-QEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE 363
Query: 370 AQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQ-RI 428
R+ E ++ E+EE+ R Q E+ E ++RE E+ M + +++E+E RQ + +I
Sbjct: 364 KMRRQEEMMWEKEEKMRRQE-EMMWEKEEKIRELEE---KMHEQEKIREQEEKRQEEEKI 419
Query: 429 KELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIER-- 486
+E E+ Q++ + + E K R EE +R Q + + +EEK+ + +++EE++R +
Sbjct: 420 REQEKRQEQEAKMWRQEEKIREQEEKIR-EQEKKMWRQEEKIHEQEKIREEEKRQEQEEM 478
Query: 487 -AQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQ 535
Q+EK Q+E+ +Q + + ++++ + + R +E + + K+R+
Sbjct: 479 WRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIRE 528
Score = 89.4 bits (220), Expect = 9e-18
Identities = 64/306 (20%), Positives = 150/306 (49%), Gaps = 19/306 (6%)
Query: 323 KDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEE 382
++L++K EQ + RE+ +EEE +R Q+ ++E+E K+ E E R+ E ++E+E
Sbjct: 394 RELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQE---EKIREQEEKIREQE 450
Query: 383 ERRRSQHREL--QQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQE 440
++ Q ++ Q+ + + + EQ Q E ++EE RQ++++ E EE ++ +E
Sbjct: 451 KKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEE 510
Query: 441 AL-QLEVKARRDEESVRIAQTRL------LEEEEEKLKQLMQLKEEQERYIERAQQEKEE 493
+ + E K R EE +R + ++ + E+EE ++ ++ E+++ + E +QE+E+
Sbjct: 511 KVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQED 570
Query: 494 ----LQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNR 549
++++ +Q + + ++++ E + RQ +E + + K+R+ ++ ++
Sbjct: 571 KMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIRE 630
Query: 550 LMHPIEPGDKRPVTSSSFSGFQPPLLAHRDSSLKRL--TRWGSQGN-RTPSPNSNEQQKS 606
I ++ G Q + ++ ++ T W + R EQ++
Sbjct: 631 QEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEK 690
Query: 607 LNGGDE 612
+ +E
Sbjct: 691 IREQEE 696
Score = 87.8 bits (216), Expect = 3e-17
Identities = 66/259 (25%), Positives = 135/259 (52%), Gaps = 20/259 (7%)
Query: 299 QRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKE 358
+ QE Q + + E K +++ ++ E+ ++E KEE++ R +++ EKE
Sbjct: 331 REQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKE 390
Query: 359 RKLQELELL---QEAQRQAERLLQEEEERRRSQHRELQQA----LEGQLRE-----AEQA 406
K++ELE QE R+ E QEEE+ R + R+ Q+A E ++RE EQ
Sbjct: 391 EKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQE 450
Query: 407 RASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEE 466
+ + E ++ E+E R+ ++ +E EEM R +E + + + R +E + + ++ ++E
Sbjct: 451 KKMWRQEEKIHEQEKIREEEKRQEQEEM-WRQEEKIHEQEEIWRQKEKMHEQEEKIRKQE 509
Query: 467 EEKLKQLMQLKEEQERYIER-----AQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQR 521
E+ +Q +++E++E+ E+ Q+EK Q+EM ++ + + ++ EE + RQ
Sbjct: 510 EKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEE--EKRQE 567
Query: 522 ADEDVEAAQRKLRQASTNV 540
++ + + K+R+ V
Sbjct: 568 QEDKMWRQEEKIREQEEKV 586
Score = 86.7 bits (213), Expect = 6e-17
Identities = 54/242 (22%), Positives = 127/242 (52%), Gaps = 7/242 (2%)
Query: 311 IRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEA 370
IR Q E + ++++ + REQ E+ ++EE +R Q+ +E K+ E E + E
Sbjct: 505 IRKQEEKVWRQEEKIREQEEKIREQEEKMW--RQEEKIREQEEMWREEEKMHEQEKIWEE 562
Query: 371 ---QRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQR 427
Q Q +++ ++EE+ R + + +Q E ++RE E+ R + +M +EE+ Q ++
Sbjct: 563 EKRQEQEDKMWRQEEKIREQEEKVWRQ--EEKIREQEEKRQEQEEKMWKQEEKIREQEEK 620
Query: 428 IKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERA 487
I+E EE + +E ++ + + +++E Q + E+EEK+++ + QE I
Sbjct: 621 IQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQ 680
Query: 488 QQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQM 547
+++ E ++++ +Q +Q+ ++++ E + +E ++ + K+R+ + V++
Sbjct: 681 EKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRL 740
Query: 548 NR 549
+
Sbjct: 741 RQ 742
Score = 85.9 bits (211), Expect = 1e-16
Identities = 56/240 (23%), Positives = 129/240 (53%), Gaps = 5/240 (2%)
Query: 298 RQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEK 357
R+++E + IR Q E + + ++ + REQ E R +EE++ +++ EE+
Sbjct: 506 RKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWR--EEEKMHEQEKIWEEE 563
Query: 358 ERKLQELELLQEAQ--RQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEME 415
+R+ QE ++ ++ + R+ E + +EE+ R Q + Q+ E ++ E+ R + +++
Sbjct: 564 KRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIR-EQEEKIQ 622
Query: 416 LKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQ 475
+EE+ Q ++I+E EEM Q +E + + + ++E Q + +EEK+++ +
Sbjct: 623 EQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEK 682
Query: 476 LKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQ 535
EQE I ++ +E +++M +Q + + +++++E + +R +E + + +LRQ
Sbjct: 683 KIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQ 742
Score = 85.5 bits (210), Expect = 1e-16
Identities = 59/265 (22%), Positives = 138/265 (52%), Gaps = 14/265 (5%)
Query: 296 DTRQRQEWTAAIQMAIRLQAE---GKTSLHK-DLKQKRREQREQRERRRAAKEEELLRLQ 351
+ RQ QE + I Q E K +H+ + K +++E++ R+ + ++EE +R Q
Sbjct: 470 EKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQ 529
Query: 352 Q----LQEEKERKLQELELLQEAQRQAERLLQEE-----EERRRSQHRELQQALEGQLRE 402
+ QEEK R+ +E+ +E + E++ +EE E++ Q ++++ E R+
Sbjct: 530 EEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQ 589
Query: 403 AEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRL 462
E+ R + E +EE+ +Q ++I+E EE Q +E ++ + + R++E + Q
Sbjct: 590 EEKIREQEEKRQE-QEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEK 648
Query: 463 LEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRA 522
+ E+EEK+ + + +EQE + R +++ E ++++ +Q +++ ++ ++E +
Sbjct: 649 MGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQ 708
Query: 523 DEDVEAAQRKLRQASTNVKHWNVQM 547
+E + + K+++ ++ +M
Sbjct: 709 EEKMCEQEEKMQEQEEKMRRQEEKM 733
Score = 84.3 bits (207), Expect = 3e-16
Identities = 52/193 (26%), Positives = 112/193 (58%), Gaps = 9/193 (4%)
Query: 326 KQKRREQREQ---RERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEE 382
++KR+EQ ++ +E + +EE++ R ++ E+E K QE E E + E ++E+E
Sbjct: 562 EEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQE---EKMWKQEEKIREQE 618
Query: 383 ERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEAL 442
E+ + Q ++++ E ++RE E+ + +M +EE+ Q ++++E EE R +E +
Sbjct: 619 EKIQEQEEKIREQ-EEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKI 677
Query: 443 -QLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQ 501
+ E K R EE +R Q +++E+EEK+ + + EQE ++ +++ +++M +Q
Sbjct: 678 REQEKKIREQEEKIR-EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQ 736
Query: 502 SRSLQQAQQQLEE 514
L+Q +++++E
Sbjct: 737 EVRLRQQEEKMQE 749
Score = 83.2 bits (204), Expect = 7e-16
Identities = 61/263 (23%), Positives = 134/263 (50%), Gaps = 26/263 (9%)
Query: 309 MAIRLQAE-GKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELL 367
++ +LQA+ + L L Q++ E+ ++E + EE++ ++ E+E K++E E
Sbjct: 277 VSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQE-- 334
Query: 368 QEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQR 427
E R+ E ++ E+EE+ R Q E+ E ++R E+ + +M +EE + ++
Sbjct: 335 -EKMRRQEEMMWEKEEKMRRQE-EMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK 392
Query: 428 IKELEEM---QQRLQE----------------ALQLEVKARRDEESVRIAQTRLLEEEEE 468
I+ELEE Q++++E + E K R EE +R + ++ E+E++
Sbjct: 393 IRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKK 452
Query: 469 KLKQLMQLKEEQERYIERAQQEKEEL--QQEMAQQSRSLQQAQQQLEEVRQNRQRADEDV 526
+Q ++ E+++ E +QE+EE+ Q+E + + + ++++ E + ++ +E V
Sbjct: 453 MWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKV 512
Query: 527 EAAQRKLRQASTNVKHWNVQMNR 549
+ K+R+ ++ +M R
Sbjct: 513 WRQEEKIREQEEKIREQEEKMWR 535
Score = 78.6 bits (192), Expect = 2e-14
Identities = 52/238 (21%), Positives = 127/238 (53%), Gaps = 13/238 (5%)
Query: 308 QMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKL--QELE 365
Q IR Q E + ++ K + +E+R+++E + +EE++ ++ E+E+K+ QE +
Sbjct: 403 QEKIREQEEKR---QEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEK 459
Query: 366 LLQEAQRQAERLLQEEEERRRSQHRELQQ----ALEGQLREAEQARASMQAEMELKEEEA 421
+ ++ + + E QE+EE R + + +Q + ++ E E+ + ++ +EE+
Sbjct: 460 IHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKI 519
Query: 422 ARQRQRIKELEEMQQRLQEALQLEVKARRDEESV----RIAQTRLLEEEEEKLKQLMQLK 477
Q ++I+E EE R +E ++ + + R+EE + +I + +E+E+K+ + +
Sbjct: 520 REQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKI 579
Query: 478 EEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQ 535
EQE + R +++ E +++ +Q + + ++++ E + Q +E + + K+R+
Sbjct: 580 REQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIRE 637
Score = 77.8 bits (190), Expect = 3e-14
Identities = 65/260 (25%), Positives = 132/260 (50%), Gaps = 36/260 (13%)
Query: 301 QEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERK 360
+E A +Q ++L K+ + ++K+ +R + + + LL QQLQ E +
Sbjct: 220 KEKNAKLQEKLQLVESEKSEIQLNVKELKR---------KLERAKLLLPQQQLQAEADHL 270
Query: 361 LQELELLQ-EAQRQAE------RLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAE 413
+EL+ + + Q Q E RL Q++EE+ Q ++Q+ E +++E E+ + +
Sbjct: 271 GKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQE-WEEKIQEQEEKIREQEEK 329
Query: 414 MELKEEEAARQRQRIKELEEMQQRLQEAL-QLEVKARRDEESV------RIAQTRLLEEE 466
+ +EE+ RQ + + E EE +R +E + + E K RR EE + Q ++ E+
Sbjct: 330 IREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEK 389
Query: 467 EEKLKQLMQLKEEQERYIE-----------RAQQEKEELQQEMAQQSRSLQQAQQQLEEV 515
EEK+++L + EQE+ E R Q++++E + +M +Q +++ ++++ E
Sbjct: 390 EEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQ 449
Query: 516 RQNRQRADEDVEAAQRKLRQ 535
+ R +E + Q K+R+
Sbjct: 450 EKKMWRQEEKIH-EQEKIRE 468
Score = 77.0 bits (188), Expect = 5e-14
Identities = 66/245 (26%), Positives = 122/245 (49%), Gaps = 26/245 (10%)
Query: 310 AIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQE 369
A+ L+ T ++LK+K + +E+ + + K E L +++L+ RKL+ +LL
Sbjct: 204 ALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELK----RKLERAKLLLP 259
Query: 370 AQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIK 429
Q+ LQ E + + + + L+ Q+ E E Q + EE+ RQ ++I+
Sbjct: 260 QQQ-----LQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQ----EEKMWRQEEKIQ 310
Query: 430 ELEEMQQRLQEAL-QLEVKARRDEESVRIAQTRLLEEEEEKLK---QLMQLKEEQERYIE 485
E EE Q +E + + E K R EE +R Q ++ E+EEK++ ++M KEE+ R E
Sbjct: 311 EWEEKIQEQEEKIREQEEKIREQEEKMR-RQEEMMWEKEEKMRRQEEMMWEKEEKMRRQE 369
Query: 486 RAQQEK-------EELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQAST 538
EK EE+ E ++ R L++ + E++R+ ++ E+ + +++ RQ
Sbjct: 370 EMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQ-EQ 428
Query: 539 NVKHW 543
K W
Sbjct: 429 EAKMW 433
Score = 73.6 bits (179), Expect = 5e-13
Identities = 47/191 (24%), Positives = 106/191 (55%), Gaps = 5/191 (2%)
Query: 296 DTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQE 355
+ RQ QE Q + E K ++ +++ E+R+++E + +EE++ ++ +
Sbjct: 563 EKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQ 622
Query: 356 EKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEME 415
E+E K++E E E R+ E + QE+EE+ Q ++ + E +++E E+ + ++
Sbjct: 623 EQEEKIREQE---EKIREQEEMTQEQEEKMGEQEEKMCEQ-EEKMQEQEETMWRQEEKIR 678
Query: 416 LKEEEAARQRQRIKELEEMQQRLQEAL-QLEVKARRDEESVRIAQTRLLEEEEEKLKQLM 474
+E++ Q ++I+E EEM Q +E + + E K EE ++ + ++ +EE+ +Q +
Sbjct: 679 EQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEV 738
Query: 475 QLKEEQERYIE 485
+L++++E+ E
Sbjct: 739 RLRQQEEKMQE 749
Score = 56.2 bits (134), Expect = 9e-08
Identities = 54/241 (22%), Positives = 112/241 (46%), Gaps = 21/241 (8%)
Query: 327 QKRREQR--EQRERRRAAKEEELLRLQQLQEE---KERKLQELELLQEAQRQAERLLQEE 381
QK++ R E+ + R A EL R EE K KLQE L E+++ +L +E
Sbjct: 187 QKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKE 246
Query: 382 EERRRSQHREL--QQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQ 439
+R+ + + L QQ L+ + + S+ A+++ + EE E+ RL
Sbjct: 247 LKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEE-----------NELWNRLN 295
Query: 440 EALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMA 499
+ Q E K R EE ++ + ++ +E+EEK+++ + EQE + R ++ E +++M
Sbjct: 296 Q--QQEEKMWRQEEKIQEWEEKI-QEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMR 352
Query: 500 QQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRLMHPIEPGDK 559
+Q + + ++++ + +E + + + + ++ +M+ E +K
Sbjct: 353 RQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEK 412
Query: 560 R 560
R
Sbjct: 413 R 413
Score = 54.3 bits (129), Expect = 3e-07
Identities = 52/233 (22%), Positives = 102/233 (43%), Gaps = 12/233 (5%)
Query: 326 KQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERR 385
+QK Q ++ RR + +R+ Q K L Q A +Q E ++ R
Sbjct: 110 EQKASHQHQEALRRELEAQVHTIRILTCQ--KTELQMALYYSQHAVKQLEGEARDLISRL 167
Query: 386 RSQHR---ELQQALEG---QLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQ 439
+ EL+QAL Q ++A++ + E + E R +EL+E +LQ
Sbjct: 168 HDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQ 227
Query: 440 EALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMA 499
E LQL V++ + E + + + + E + L QL+ E + + Q +LQ ++
Sbjct: 228 EKLQL-VESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVE 286
Query: 500 QQ---SRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNR 549
+ +R QQ ++++ + Q +E ++ + K+R+ ++ +M R
Sbjct: 287 ENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRR 339
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 93.2 bits (230), Expect = 6e-19
Identities = 81/297 (27%), Positives = 147/297 (49%), Gaps = 21/297 (7%)
Query: 288 RTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQR-ERRRAAKEEE 346
RT+ + + T+A + ++ + T L D K E+ QR E R +E E
Sbjct: 493 RTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAE 552
Query: 347 LLRLQQLQEEKERKLQELELLQEAQ-----RQAERLLQEEEERRRSQHRELQQ------- 394
LR Q+++E+K R+L+E++L +E + + ER+ Q +EE+++ ++ Q
Sbjct: 553 QLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEK 612
Query: 395 ALEGQLREAEQARASMQAEME-----LKEEEAARQRQRIKELEEMQQRLQEALQLEVKAR 449
A E +L E + + + +ME K+EE AR R R + EE ++R QE LQ + K
Sbjct: 613 AKEERLAEEKAKKKAAAKKMEEVEARRKQEEEAR-RLRWLQQEEEERRHQELLQKK-KEE 670
Query: 450 RDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQ 509
E + A+ + L E+ E+ ++ + +E++ R ER +QE+ E ++++A+Q R +Q +
Sbjct: 671 EQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQER 730
Query: 510 QQLEEVRQNRQRADE-DVEAAQRKLRQASTNVKHWNVQMNRLMHPIEPGDKRPVTSS 565
Q E Q R++A E QR+L + + + +L E K +S
Sbjct: 731 LQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGAS 787
Score = 90.1 bits (222), Expect = 5e-18
Identities = 74/213 (34%), Positives = 118/213 (55%), Gaps = 24/213 (11%)
Query: 313 LQAEGKTSLHKDLKQKRREQREQR--ERRRAAKEEELLRLQQLQEEKERKLQELELLQEA 370
LQA + K+ K+K+ EQ+ + E+ AKEE L + ++ +K++E+E ++
Sbjct: 582 LQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQ 641
Query: 371 QRQAERL--LQEEEERRRSQHRELQQALEGQLRE-----AEQARASMQAEMELKEEEAAR 423
+ +A RL LQ+EEE RR H+EL Q + + +E AE R + Q E E +E+E
Sbjct: 642 EEEARRLRWLQQEEEERR--HQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERRE 699
Query: 424 QRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLK-QLMQL------ 476
Q +R +E E ++R QE E + RR++E R+ R L+E E+ L+ Q QL
Sbjct: 700 QERREQERREQERREQERQLAEQERRREQE--RLQAERELQEREKALRLQKEQLQRELEE 757
Query: 477 ---KEEQERYIER-AQQEKEELQQEMAQQSRSL 505
KEEQ+R ER Q+E+E+ +E A S++L
Sbjct: 758 KKKKEEQQRLAERQLQEEQEKKAKEAAGASKAL 790
Score = 81.3 bits (199), Expect = 3e-15
Identities = 77/272 (28%), Positives = 138/272 (50%), Gaps = 30/272 (11%)
Query: 272 PDRDGKRCMFCVKTANRTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRRE 331
P R +C F K R + R+++E A Q+ + E K +++K KR E
Sbjct: 525 PLRMDPKCSFVEKERQRLENL-----RRKEE---AEQLRRQKVEEDKRRRLEEVKLKREE 576
Query: 332 QREQ----RERRRAAKEEELLRLQQLQ---EEKERKLQELELLQE-AQRQAERLLQEEEE 383
+ + RER KEE+ +++Q +EK K +E L +E A+++A EE E
Sbjct: 577 RLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVE 636
Query: 384 RRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQ 443
RR Q E ++ L++ E+ R + + KEEE R R+ + +QR QE +
Sbjct: 637 ARRKQEEEARRL--RWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERRE 694
Query: 444 LEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSR 503
E RR++E R Q R +E E+ +QL EQER R +QE+ + ++E+ ++ +
Sbjct: 695 QE---RREQE--RREQERREQERREQERQL----AEQER---RREQERLQAERELQEREK 742
Query: 504 SLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQ 535
+L+ ++QL+ + +++ +E A+R+L++
Sbjct: 743 ALRLQKEQLQRELEEKKKKEEQQRLAERQLQE 774
Score = 48.9 bits (115), Expect = 1e-05
Identities = 39/142 (27%), Positives = 69/142 (48%), Gaps = 24/142 (16%)
Query: 312 RLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQ 371
R + E + ++ +++ +E+REQ +QL E++ R+ QE +
Sbjct: 692 RREQERREQERREQERREQERREQE--------------RQLAEQERRREQE-------R 730
Query: 372 RQAERLLQEEEERRRSQHRELQQALEGQLREAEQARAS---MQAEMELKEEEAARQRQRI 428
QAER LQE E+ R Q +LQ+ LE + ++ EQ R + +Q E E K +EAA + +
Sbjct: 731 LQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKAL 790
Query: 429 KELEEMQQRLQEALQLEVKARR 450
++Q + Q+ + R
Sbjct: 791 NVTVDVQSPACTSYQMTPQGHR 812
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 92.4 bits (228), Expect = 1e-18
Identities = 77/291 (26%), Positives = 144/291 (49%), Gaps = 34/291 (11%)
Query: 291 EMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQ-RERRRAAKEEELLR 349
E + + RQ QE ++ ++ +++ K +L + + + E RE++RA + E LR
Sbjct: 1483 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1542
Query: 350 LQQLQEEKERKLQELEL---------LQEAQRQAERLLQEEEERRRSQHRELQQALE--- 397
LQ EE ER+L++ E+ L+ AQR AE LQ + + +L+++L+
Sbjct: 1543 LQA--EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEH 1600
Query: 398 ---GQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEES 454
QLRE + RA QAE E EEA R ELE Q + EAL+L ++A +
Sbjct: 1601 VAVAQLREEAERRAQQQAEAERAREEAER------ELERWQLKANEALRLRLQAEEVAQQ 1654
Query: 455 VRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQ---AQQQ 511
+AQ +++EE ++ + + +E+ + + + ++EL+++ + QQ A+Q+
Sbjct: 1655 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1714
Query: 512 L-------EEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRLMHPIE 555
L E+ Q RQ +E++ QR+ A+ + ++ ++ +E
Sbjct: 1715 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1765
Score = 87.0 bits (214), Expect = 5e-17
Identities = 76/268 (28%), Positives = 133/268 (49%), Gaps = 26/268 (9%)
Query: 288 RTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQR-------ERRR 340
R E +A +E A ++ A + E + L +D ++RR+ E+ E+
Sbjct: 1879 RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1938
Query: 341 AAKEE---ELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALE 397
A K E EL R++ E+ R ++ EL QRQ L EEE RRR +Q++L
Sbjct: 1939 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ---LAAEEERRRREAEERVQKSLA 1995
Query: 398 GQLREAEQARASMQ--AEMELKEEEAARQRQR-----IKELEEMQQRLQEALQLEVKARR 450
+ A Q +A+++ ++ K EEA R R+R ++L+ Q+ Q+ LQ E KA
Sbjct: 1996 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2055
Query: 451 ---DEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQ 507
++ + QT L++E+ L QL E R E A++ + + ++E AQ R +++
Sbjct: 2056 FAVQQKEQELQQT--LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2113
Query: 508 AQQQLEEVRQNRQRADEDVEAAQRKLRQ 535
A ++L++ + + +A +AA KLR+
Sbjct: 2114 A-ERLKQSAEEQAQARAQAQAAAEKLRK 2140
Score = 86.7 bits (213), Expect = 6e-17
Identities = 75/282 (26%), Positives = 136/282 (48%), Gaps = 27/282 (9%)
Query: 286 ANRTYEMSASDTRQRQEWTAAIQMAIRLQAEG----KTSLHK--DLKQKRREQREQRERR 339
A R +++A + R+R+E +Q ++ + E K +L + LK K E R RER
Sbjct: 1969 AARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRER- 2027
Query: 340 RAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQ 399
A++E +LQ QE +++LQ A+ +A +++E+ Q + +Q++ Q
Sbjct: 2028 --AEQESARQLQLAQEAAQKRLQ-------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2078
Query: 400 LR-EAEQARASMQAEMELK---EEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESV 455
LR EAE AR + + E + E EAA+ R++++E E ++Q +E Q +A+ E +
Sbjct: 2079 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2138
Query: 456 R----IAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQ---EKEELQQEMAQQSRSLQQA 508
R R + E+ L+Q E E++ + A+Q +K +++QE+ L++
Sbjct: 2139 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2198
Query: 509 QQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRL 550
Q + + QR + A R+ Q + VQM L
Sbjct: 2199 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2240
Score = 84.3 bits (207), Expect = 3e-16
Identities = 98/385 (25%), Positives = 178/385 (46%), Gaps = 54/385 (14%)
Query: 288 RTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRR-EQREQRERRRAAKEEE 346
R + A +Q E A + +A + A + +DL Q+R ++ +E+ +A +E
Sbjct: 2264 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2323
Query: 347 LLRLQQ--LQEEKERKLQELELLQEAQRQ-AERLLQEEEERRRSQHRELQQALEG----- 398
L+ + LQ++KE ++ LQE + Q A++L +E + +R+ E Q+ LE
Sbjct: 2324 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2383
Query: 399 --QLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEV---------K 447
+LR AE +RA +AE E+A R R++ +E+ E R + A Q +V +
Sbjct: 2384 RLKLRVAEMSRAQARAE-----EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQR 2438
Query: 448 ARRDEESVRIAQT-RLLEEEEEKLKQ---LMQLKEEQERYIERAQ--QEKEELQQ----- 496
+ D ++ R+ + LE E+EKL+Q L+QLK E+ + +++ Q QE + LQQ
Sbjct: 2439 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2498
Query: 497 --EMAQQSRSLQQAQQQLEEVRQNR----QRADEDVEAAQRKLRQASTNVKHWNVQMNRL 550
+ Q+ R ++Q + +LE++ Q+ Q+ E+ + Q+++ Q + + R
Sbjct: 2499 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRR 2558
Query: 551 MHPIEPGDKRPVTS----SSFSGFQPPLLAHRDSSLKRLTRWGSQGNRTPSPNSNEQQKS 606
H E G +R Q LLA + L+ + + +R +S E S
Sbjct: 2559 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2618
Query: 607 L--------NGGDEAPAPASTPQED 623
NG D PA+ + +
Sbjct: 2619 QVAATKTLPNGRDALDGPAAEAEPE 2643
Score = 82.8 bits (203), Expect = 9e-16
Identities = 80/306 (26%), Positives = 140/306 (45%), Gaps = 37/306 (12%)
Query: 291 EMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRL 350
E A+ +R++ E ++ + QA+ + +K R++ EQ RRA E+ LR
Sbjct: 2101 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQA-AAEKLRKEAEQEAARRAQAEQAALRQ 2159
Query: 351 QQLQE---EKERKLQELELLQEAQRQAE----RLLQEEEERRRSQHRELQQALEGQLREA 403
+Q + EK +K E L Q+AQ + E RL EE + +++ E Q L+ + EA
Sbjct: 2160 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2219
Query: 404 EQARASMQAEM---ELKEEEAARQRQRIK--------------------ELEEMQQRLQE 440
+ R+ ++ E+ ++ EE ++ + RI+ E E+M+Q +E
Sbjct: 2220 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2279
Query: 441 ALQLEVKARRDEESVRIAQTRLLEEE---EEKLKQLMQLKEEQERY---IERAQQEKEEL 494
A +L V A+ ++A+ L ++ E+ LK+ MQ +E R E QQ+KE
Sbjct: 2280 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA 2339
Query: 495 QQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRLMHPI 554
Q++ + +Q QQL E Q QR E Q ++ + +K +M+R
Sbjct: 2340 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2399
Query: 555 EPGDKR 560
E +R
Sbjct: 2400 EEDAQR 2405
Score = 81.6 bits (200), Expect = 2e-15
Identities = 75/298 (25%), Positives = 139/298 (46%), Gaps = 38/298 (12%)
Query: 288 RTYEMSASDTRQR-QEWTAAIQMAIRL---QAEGKTSLHKDLKQKRREQREQRERRRAAK 343
R E ++ R+R E AA++ +L A+ K ++ K+ ++ +E+ RR
Sbjct: 1349 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR---- 1404
Query: 344 EEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREA 403
EE + QQ + + +LQ+L EA+ QA+ E ER R + E + + QL
Sbjct: 1405 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1464
Query: 404 EQARASMQAEMEL----KEEEAARQRQRIKELEEMQQRLQEALQ--------------LE 445
E+ R + E++ EE A++RQ +E E +++++Q+ Q E
Sbjct: 1465 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1524
Query: 446 VKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYI----ERAQQEKE-ELQ----- 495
+A R+++ A L + EE ++L Q + E+ R + E AQ+ E ELQ
Sbjct: 1525 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1584
Query: 496 --QEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRLM 551
++ AQ RSLQ+ + ++R+ +R + A+R +A ++ W ++ N +
Sbjct: 1585 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1642
Score = 80.1 bits (196), Expect = 6e-15
Identities = 65/220 (29%), Positives = 109/220 (49%), Gaps = 23/220 (10%)
Query: 337 ERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQAL 396
E R +EEE L QQ EE+ER L E+E E QRQ + + + + +ELQQ +
Sbjct: 1339 ETLRRMEEEERLAEQQRAEERER-LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1397
Query: 397 EGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVR 456
+ ++ E+A Q + +EE + RQ + E+Q + ++A E R EE +R
Sbjct: 1398 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA--EIQAKARQAEAAERSRLRIEEEIR 1455
Query: 457 IAQTRLLEEEEEK------LKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQ 510
+ + +L E ++ L+ L EE E +AQ+E E L++++ +S+ +QA+
Sbjct: 1456 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1515
Query: 511 QLE-------EVRQNRQRADE-------DVEAAQRKLRQA 536
+L E + +QRA + E A+R+LRQA
Sbjct: 1516 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQA 1555
Score = 78.2 bits (191), Expect = 2e-14
Identities = 84/330 (25%), Positives = 153/330 (46%), Gaps = 58/330 (17%)
Query: 275 DGKRCMFCVKTANRTYEMSASDT-RQRQEWTAAIQMAIRLQAEGK-TSLHKDLKQKRREQ 332
+ R + A R +++ D RQR E A +A +L A G+ T L + + +E+
Sbjct: 1802 EAARLRALAEEAKRQRQLAEEDAARQRAE--AERVLAEKLAAIGEATRLKTEAEIALKEK 1859
Query: 333 REQRERRRAAKEEELLRLQQLQEEK-------ERKLQELELLQEAQRQAERLLQEEEERR 385
+ ER R E+E + ++L+E+ E +L +L +++ + ++ L E+ R+
Sbjct: 1860 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 1919
Query: 386 RSQHRELQQALEGQLREAEQARASMQAEM--------------ELKEEEAARQRQRIKEL 431
R Q E AL+ +A +A ++ E+ E E EAARQRQ E
Sbjct: 1920 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1979
Query: 432 E----EMQQRLQEALQLEVKARRDEESV---------RIAQTRLLEE--EEEKLKQLM-- 474
E E ++R+Q++L E +A R ++ ++ + R L E E+E +QL
Sbjct: 1980 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2039
Query: 475 ------QLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVR---QNRQRADED 525
+L+ E++ + QQ+++ELQQ +LQQ Q L+++R + +RA E+
Sbjct: 2040 QEAAQKRLQAEEKAHAFAVQQKEQELQQ-------TLQQEQSVLDQLRGEAEAARRAAEE 2092
Query: 526 VEAAQRKLRQASTNVKHWNVQMNRLMHPIE 555
E A+ + + + + + RL E
Sbjct: 2093 AEEARVQAEREAAQSRRQVEEAERLKQSAE 2122
Score = 78.2 bits (191), Expect = 2e-14
Identities = 72/254 (28%), Positives = 127/254 (50%), Gaps = 27/254 (10%)
Query: 291 EMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRL 350
E+ R E T + L+A + L + +++RR + E+R ++ A EEE R
Sbjct: 1945 ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE-EERRRREAEERVQKSLAAEEEAAR- 2002
Query: 351 QQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASM 410
+++ L+E+E L+ +A RL + E+ Q + Q+A + +L+ E+A A
Sbjct: 2003 -----QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2057
Query: 411 QAEMELKEEEAARQRQRIK-----ELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEE 465
+ E + ++ +Q Q + E E ++ +EA + V+A R+ AQ+R E
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA-----AQSRRQVE 2112
Query: 466 EEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADED 525
E E+LKQ EEQ + +AQ E+L++E Q++ QA+Q +RQ +Q AD +
Sbjct: 2113 EAERLKQSA---EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA--LRQ-KQAADAE 2166
Query: 526 VEA----AQRKLRQ 535
+E A++ LRQ
Sbjct: 2167 MEKHKKFAEQTLRQ 2180
Score = 76.6 bits (187), Expect = 6e-14
Identities = 77/302 (25%), Positives = 146/302 (48%), Gaps = 37/302 (12%)
Query: 251 EECKEKRGIIPLDAHCCVEVLPDRDGKRCMFCVKTANRTYEMSASDTRQRQ-EWTAAIQM 309
E ++++ + L + E R+ +R + ++ E + RQ + E +Q+
Sbjct: 1506 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1565
Query: 310 AIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQE 369
A+ + S +L+ KR E+ + + +EE + + QL+EE ER+ Q+ +
Sbjct: 1566 ALET---AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1622
Query: 370 AQRQAERLLQE------EEERRRSQHRELQQALEGQLREAEQARASMQAEMELK-----E 418
A+ +AER L+ E R R Q E+ Q + L +AE + +AE E + E
Sbjct: 1623 AREEAERELERWQLKANEALRLRLQAEEVAQ--QKSLAQAEAEKQKEEAEREARRRGKAE 1680
Query: 419 EEAARQRQRIK-ELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLK 477
E+A RQR+ + ELE+ +Q + Q + A ++E +R L E E+ +Q QL
Sbjct: 1681 EQAVRQRELAEQELEKQRQLAEGTAQQRLAA--EQELIR------LRAETEQGEQQRQLL 1732
Query: 478 EEQERYIER----AQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKL 533
EE+ ++R A Q+++EL+ E+A + + ++E + ++ RA+E+ + K
Sbjct: 1733 EEELARLQREAAAATQKRQELEAELA-------KVRAEMEVLLASKARAEEESRSTSEKS 1785
Query: 534 RQ 535
+Q
Sbjct: 1786 KQ 1787
Score = 74.3 bits (181), Expect = 3e-13
Identities = 81/293 (27%), Positives = 141/293 (48%), Gaps = 38/293 (12%)
Query: 284 KTANRTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQ---KRREQREQRERRR 340
+ A R + RQR+ ++ +L AEG +Q + R + EQ E++R
Sbjct: 1671 REARRRGKAEEQAVRQRELAEQELEKQRQL-AEGTAQQRLAAEQELIRLRAETEQGEQQR 1729
Query: 341 AAKEEELLRLQQLQEEKERKLQELEL-LQEAQRQAERLLQEE---EERRRSQHRELQQAL 396
EEEL RLQ+ +K QELE L + + + E LL + EE RS + +Q L
Sbjct: 1730 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1789
Query: 397 E---GQLRE-----------AEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEAL 442
E G+ RE AE+A+ Q L EE+AARQR E ++ L E L
Sbjct: 1790 EAEAGRFRELAEEAARLRALAEEAKRQRQ----LAEEDAARQR------AEAERVLAEKL 1839
Query: 443 QLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYI-ERAQQEKEELQQEMAQQ 501
+A R + IA + E E E+L++L + + Q R + E+A Q K ++++ +AQ
Sbjct: 1840 AAIGEATRLKTEAEIA-LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1898
Query: 502 SRS----LQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRL 550
++ L++ + +E+ + R++ +E++ A + +A+ +++ R+
Sbjct: 1899 RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1951
Score = 62.8 bits (151), Expect = 9e-10
Identities = 76/303 (25%), Positives = 138/303 (45%), Gaps = 61/303 (20%)
Query: 296 DTRQRQEWTAAIQMA----IRLQAEGKTSLHKDLKQKRRE----QREQRERRRAAKEEEL 347
D R+RQE A+ +A +R Q + +L +++++ + QR ++ A K+ EL
Sbjct: 1225 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYEL 1284
Query: 348 ---------------LRLQQLQEEKERKLQELELLQEAQRQ------------AERLLQE 380
+ ++Q E +QE L+ + +E L +
Sbjct: 1285 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1344
Query: 381 EEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQE 440
EEE R ++ QQ E + R AE A+++ + +L E A + Q +E +E+QQR+QE
Sbjct: 1345 EEEERLAE----QQRAEERERLAE-VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE 1399
Query: 441 ALQLEVKARRDEESVRI-AQTRLLEEEEEKLKQL----MQLKEEQERYIERAQQEKEE-- 493
+ RR+E +V Q R ++EE ++L+Q +Q K Q ER++ EE
Sbjct: 1400 EV-----VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1454
Query: 494 ----LQQEMAQQSR-----SLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWN 544
LQ E ++ R LQ + + EE +++A E+ E +R+++ S +
Sbjct: 1455 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1514
Query: 545 VQM 547
V++
Sbjct: 1515 VEL 1517
Score = 45.1 bits (105), Expect = 2e-04
Identities = 45/154 (29%), Positives = 72/154 (46%), Gaps = 12/154 (7%)
Query: 336 RERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQA 395
R AK+E L + E KE+K++EL Q +RLL+E+ R + Q A
Sbjct: 647 RNTNMTAKKESYSALMRELELKEKKIKEL------QNAGDRLLREDHPARPTV-ESFQAA 699
Query: 396 LEGQLREAEQARASMQAEMELKEEEAARQ-RQRIKELEEMQQRLQEALQLEVKARRDEES 454
L+ Q Q ++A LKE A Q ++E E Q+LQEAL+ + R
Sbjct: 700 LQTQWSWMLQLCCCIEA--HLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 757
Query: 455 VRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQ 488
R+ LL++ +++ +QL + K +RA+
Sbjct: 758 TRLED--LLQDAQDEKEQLNEYKGHLSGLAKRAK 789
Score = 38.9 bits (89), Expect = 0.015
Identities = 68/281 (24%), Positives = 125/281 (44%), Gaps = 44/281 (15%)
Query: 274 RDGKRCMFCV-KTANRTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQ 332
++ RC C+ + + ++ A +TR ++ + L E + + ++++ Q
Sbjct: 977 QEESRCQRCISELKDIRLQLEACETR------TVHRLRLPLDKEPARECAQRIAEQQKAQ 1030
Query: 333 RE-----QRERRRAAKEEELLRLQQ-------LQEEKERKLQELELLQEAQR-QAERLLQ 379
E + R +A+ E++L L + L+ E E L +LE ++ E+L
Sbjct: 1031 AEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKT 1090
Query: 380 EEEERRRSQH-RELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRL 438
R +Q E+ +A E QL+EA+ A++ EL+ +A+ ++ R +
Sbjct: 1091 ISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP---ELEATKASLKKLRAQA-------- 1139
Query: 439 QEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKE-EQERYIERAQQEKEELQQE 497
EA Q A RDE R +E E+L+Q ++ E ER+ ER Q E Q
Sbjct: 1140 -EAQQPTFDALRDE-------LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAV 1191
Query: 498 MAQ---QSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQ 535
+AQ + R L+Q +QL R++ ++ A+R+ Q
Sbjct: 1192 LAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1232
Score = 38.5 bits (88), Expect = 0.019
Identities = 59/265 (22%), Positives = 117/265 (44%), Gaps = 36/265 (13%)
Query: 312 RLQAE---GKTSLHKDLKQKRREQREQRERR--RAAKEEELLRLQQLQEEKERKLQELEL 366
RL AE G S H + EQ Q E R R E + +RLQ L+ + R + L L
Sbjct: 951 RLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQ-LEACETRTVHRLRL 1009
Query: 367 ---LQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARA---------SMQAEM 414
+ A+ A+R+ E+++ +++ L + + EAE+ A ++++E+
Sbjct: 1010 PLDKEPARECAQRIA--EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL 1067
Query: 415 ELK----EEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQT-----RLLEE 465
EL E+ + +++L+ + ++ E R EE ++ AQ LE
Sbjct: 1068 ELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1127
Query: 466 EEEKLKQLMQLKEEQERYIER-------AQQEKEELQQEMAQQSRSLQQAQQQLEEVRQN 518
+ LK+L E Q+ + AQ+ E LQQ ++ +++ ++++ ++ +
Sbjct: 1128 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1187
Query: 519 RQRADEDVEAAQRKLRQASTNVKHW 543
Q + QR+L Q ++++
Sbjct: 1188 WQAVLAQTDVRQRELEQLGRQLRYY 1212
Score = 37.4 bits (85), Expect = 0.042
Identities = 45/184 (24%), Positives = 80/184 (43%), Gaps = 17/184 (9%)
Query: 342 AKEEELLRLQQLQ------EEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQA 395
A EE+L Q + E + L++L EAQ+ L++E + LQQ
Sbjct: 1107 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1166
Query: 396 LEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLE-------VKA 448
+ E E+ R + +E + A+ R +ELE++ ++L+ + A
Sbjct: 1167 HGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA 1226
Query: 449 RRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQA 508
RR +E ++ + E+L+Q L EE ER+ E+ EE Q+ Q +++
Sbjct: 1227 RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKV----EECQRFAKQYINAIKDY 1282
Query: 509 QQQL 512
+ QL
Sbjct: 1283 ELQL 1286
Score = 31.2 bits (69), Expect = 3.0
Identities = 47/203 (23%), Positives = 84/203 (41%), Gaps = 20/203 (9%)
Query: 339 RRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEG 398
R E RL+ LQ + E L +E QA+ LLQ + R + + Q+A E
Sbjct: 380 REKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQ-SDVRLLAAGKVPQRAGEV 438
Query: 399 QLREAEQARA-------SMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRD 451
+ R+ ++A + +Q + + + + +R+ L E ++ L +KA
Sbjct: 439 E-RDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVA 497
Query: 452 EESVRIAQTRLL------EEEEEKLKQLMQL---KEEQERYIERAQQEKEELQQEMAQQS 502
+ ++AQ L E E+ L+ L L EE + ++ A+ + + Q
Sbjct: 498 APATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVD--LPSVEAQL 555
Query: 503 RSLQQAQQQLEEVRQNRQRADED 525
S + Q +EE R +RA D
Sbjct: 556 GSHRGLHQSIEEFRAKIERARSD 578
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 92.4 bits (228), Expect = 1e-18
Identities = 77/291 (26%), Positives = 144/291 (49%), Gaps = 34/291 (11%)
Query: 291 EMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQ-RERRRAAKEEELLR 349
E + + RQ QE ++ ++ +++ K +L + + + E RE++RA + E LR
Sbjct: 1487 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1546
Query: 350 LQQLQEEKERKLQELEL---------LQEAQRQAERLLQEEEERRRSQHRELQQALE--- 397
LQ EE ER+L++ E+ L+ AQR AE LQ + + +L+++L+
Sbjct: 1547 LQA--EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEH 1604
Query: 398 ---GQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEES 454
QLRE + RA QAE E EEA R ELE Q + EAL+L ++A +
Sbjct: 1605 VAVAQLREEAERRAQQQAEAERAREEAER------ELERWQLKANEALRLRLQAEEVAQQ 1658
Query: 455 VRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQ---AQQQ 511
+AQ +++EE ++ + + +E+ + + + ++EL+++ + QQ A+Q+
Sbjct: 1659 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1718
Query: 512 L-------EEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRLMHPIE 555
L E+ Q RQ +E++ QR+ A+ + ++ ++ +E
Sbjct: 1719 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1769
Score = 87.0 bits (214), Expect = 5e-17
Identities = 76/268 (28%), Positives = 133/268 (49%), Gaps = 26/268 (9%)
Query: 288 RTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQR-------ERRR 340
R E +A +E A ++ A + E + L +D ++RR+ E+ E+
Sbjct: 1883 RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1942
Query: 341 AAKEE---ELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALE 397
A K E EL R++ E+ R ++ EL QRQ L EEE RRR +Q++L
Sbjct: 1943 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ---LAAEEERRRREAEERVQKSLA 1999
Query: 398 GQLREAEQARASMQ--AEMELKEEEAARQRQR-----IKELEEMQQRLQEALQLEVKARR 450
+ A Q +A+++ ++ K EEA R R+R ++L+ Q+ Q+ LQ E KA
Sbjct: 2000 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2059
Query: 451 ---DEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQ 507
++ + QT L++E+ L QL E R E A++ + + ++E AQ R +++
Sbjct: 2060 FAVQQKEQELQQT--LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2117
Query: 508 AQQQLEEVRQNRQRADEDVEAAQRKLRQ 535
A ++L++ + + +A +AA KLR+
Sbjct: 2118 A-ERLKQSAEEQAQARAQAQAAAEKLRK 2144
Score = 86.7 bits (213), Expect = 6e-17
Identities = 75/282 (26%), Positives = 136/282 (48%), Gaps = 27/282 (9%)
Query: 286 ANRTYEMSASDTRQRQEWTAAIQMAIRLQAEG----KTSLHK--DLKQKRREQREQRERR 339
A R +++A + R+R+E +Q ++ + E K +L + LK K E R RER
Sbjct: 1973 AARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRER- 2031
Query: 340 RAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQ 399
A++E +LQ QE +++LQ A+ +A +++E+ Q + +Q++ Q
Sbjct: 2032 --AEQESARQLQLAQEAAQKRLQ-------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2082
Query: 400 LR-EAEQARASMQAEMELK---EEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESV 455
LR EAE AR + + E + E EAA+ R++++E E ++Q +E Q +A+ E +
Sbjct: 2083 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2142
Query: 456 R----IAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQ---EKEELQQEMAQQSRSLQQA 508
R R + E+ L+Q E E++ + A+Q +K +++QE+ L++
Sbjct: 2143 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2202
Query: 509 QQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRL 550
Q + + QR + A R+ Q + VQM L
Sbjct: 2203 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2244
Score = 84.3 bits (207), Expect = 3e-16
Identities = 98/385 (25%), Positives = 178/385 (46%), Gaps = 54/385 (14%)
Query: 288 RTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRR-EQREQRERRRAAKEEE 346
R + A +Q E A + +A + A + +DL Q+R ++ +E+ +A +E
Sbjct: 2268 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2327
Query: 347 LLRLQQ--LQEEKERKLQELELLQEAQRQ-AERLLQEEEERRRSQHRELQQALEG----- 398
L+ + LQ++KE ++ LQE + Q A++L +E + +R+ E Q+ LE
Sbjct: 2328 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2387
Query: 399 --QLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEV---------K 447
+LR AE +RA +AE E+A R R++ +E+ E R + A Q +V +
Sbjct: 2388 RLKLRVAEMSRAQARAE-----EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQR 2442
Query: 448 ARRDEESVRIAQT-RLLEEEEEKLKQ---LMQLKEEQERYIERAQ--QEKEELQQ----- 496
+ D ++ R+ + LE E+EKL+Q L+QLK E+ + +++ Q QE + LQQ
Sbjct: 2443 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2502
Query: 497 --EMAQQSRSLQQAQQQLEEVRQNR----QRADEDVEAAQRKLRQASTNVKHWNVQMNRL 550
+ Q+ R ++Q + +LE++ Q+ Q+ E+ + Q+++ Q + + R
Sbjct: 2503 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRR 2562
Query: 551 MHPIEPGDKRPVTS----SSFSGFQPPLLAHRDSSLKRLTRWGSQGNRTPSPNSNEQQKS 606
H E G +R Q LLA + L+ + + +R +S E S
Sbjct: 2563 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2622
Query: 607 L--------NGGDEAPAPASTPQED 623
NG D PA+ + +
Sbjct: 2623 QVAATKTLPNGRDALDGPAAEAEPE 2647
Score = 82.8 bits (203), Expect = 9e-16
Identities = 80/306 (26%), Positives = 140/306 (45%), Gaps = 37/306 (12%)
Query: 291 EMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRL 350
E A+ +R++ E ++ + QA+ + +K R++ EQ RRA E+ LR
Sbjct: 2105 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQA-AAEKLRKEAEQEAARRAQAEQAALRQ 2163
Query: 351 QQLQE---EKERKLQELELLQEAQRQAE----RLLQEEEERRRSQHRELQQALEGQLREA 403
+Q + EK +K E L Q+AQ + E RL EE + +++ E Q L+ + EA
Sbjct: 2164 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2223
Query: 404 EQARASMQAEM---ELKEEEAARQRQRIK--------------------ELEEMQQRLQE 440
+ R+ ++ E+ ++ EE ++ + RI+ E E+M+Q +E
Sbjct: 2224 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2283
Query: 441 ALQLEVKARRDEESVRIAQTRLLEEE---EEKLKQLMQLKEEQERY---IERAQQEKEEL 494
A +L V A+ ++A+ L ++ E+ LK+ MQ +E R E QQ+KE
Sbjct: 2284 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA 2343
Query: 495 QQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRLMHPI 554
Q++ + +Q QQL E Q QR E Q ++ + +K +M+R
Sbjct: 2344 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2403
Query: 555 EPGDKR 560
E +R
Sbjct: 2404 EEDAQR 2409
Score = 81.6 bits (200), Expect = 2e-15
Identities = 75/298 (25%), Positives = 139/298 (46%), Gaps = 38/298 (12%)
Query: 288 RTYEMSASDTRQR-QEWTAAIQMAIRL---QAEGKTSLHKDLKQKRREQREQRERRRAAK 343
R E ++ R+R E AA++ +L A+ K ++ K+ ++ +E+ RR
Sbjct: 1353 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR---- 1408
Query: 344 EEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREA 403
EE + QQ + + +LQ+L EA+ QA+ E ER R + E + + QL
Sbjct: 1409 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1468
Query: 404 EQARASMQAEMEL----KEEEAARQRQRIKELEEMQQRLQEALQ--------------LE 445
E+ R + E++ EE A++RQ +E E +++++Q+ Q E
Sbjct: 1469 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1528
Query: 446 VKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYI----ERAQQEKE-ELQ----- 495
+A R+++ A L + EE ++L Q + E+ R + E AQ+ E ELQ
Sbjct: 1529 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1588
Query: 496 --QEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRLM 551
++ AQ RSLQ+ + ++R+ +R + A+R +A ++ W ++ N +
Sbjct: 1589 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1646
Score = 80.1 bits (196), Expect = 6e-15
Identities = 65/220 (29%), Positives = 109/220 (49%), Gaps = 23/220 (10%)
Query: 337 ERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQAL 396
E R +EEE L QQ EE+ER L E+E E QRQ + + + + +ELQQ +
Sbjct: 1343 ETLRRMEEEERLAEQQRAEERER-LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1401
Query: 397 EGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVR 456
+ ++ E+A Q + +EE + RQ + E+Q + ++A E R EE +R
Sbjct: 1402 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA--EIQAKARQAEAAERSRLRIEEEIR 1459
Query: 457 IAQTRLLEEEEEK------LKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQ 510
+ + +L E ++ L+ L EE E +AQ+E E L++++ +S+ +QA+
Sbjct: 1460 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1519
Query: 511 QLE-------EVRQNRQRADE-------DVEAAQRKLRQA 536
+L E + +QRA + E A+R+LRQA
Sbjct: 1520 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQA 1559
Score = 78.2 bits (191), Expect = 2e-14
Identities = 84/330 (25%), Positives = 153/330 (46%), Gaps = 58/330 (17%)
Query: 275 DGKRCMFCVKTANRTYEMSASDT-RQRQEWTAAIQMAIRLQAEGK-TSLHKDLKQKRREQ 332
+ R + A R +++ D RQR E A +A +L A G+ T L + + +E+
Sbjct: 1806 EAARLRALAEEAKRQRQLAEEDAARQRAE--AERVLAEKLAAIGEATRLKTEAEIALKEK 1863
Query: 333 REQRERRRAAKEEELLRLQQLQEEK-------ERKLQELELLQEAQRQAERLLQEEEERR 385
+ ER R E+E + ++L+E+ E +L +L +++ + ++ L E+ R+
Sbjct: 1864 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 1923
Query: 386 RSQHRELQQALEGQLREAEQARASMQAEM--------------ELKEEEAARQRQRIKEL 431
R Q E AL+ +A +A ++ E+ E E EAARQRQ E
Sbjct: 1924 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1983
Query: 432 E----EMQQRLQEALQLEVKARRDEESV---------RIAQTRLLEE--EEEKLKQLM-- 474
E E ++R+Q++L E +A R ++ ++ + R L E E+E +QL
Sbjct: 1984 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2043
Query: 475 ------QLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVR---QNRQRADED 525
+L+ E++ + QQ+++ELQQ +LQQ Q L+++R + +RA E+
Sbjct: 2044 QEAAQKRLQAEEKAHAFAVQQKEQELQQ-------TLQQEQSVLDQLRGEAEAARRAAEE 2096
Query: 526 VEAAQRKLRQASTNVKHWNVQMNRLMHPIE 555
E A+ + + + + + RL E
Sbjct: 2097 AEEARVQAEREAAQSRRQVEEAERLKQSAE 2126
Score = 78.2 bits (191), Expect = 2e-14
Identities = 72/254 (28%), Positives = 127/254 (50%), Gaps = 27/254 (10%)
Query: 291 EMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRL 350
E+ R E T + L+A + L + +++RR + E+R ++ A EEE R
Sbjct: 1949 ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE-EERRRREAEERVQKSLAAEEEAAR- 2006
Query: 351 QQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASM 410
+++ L+E+E L+ +A RL + E+ Q + Q+A + +L+ E+A A
Sbjct: 2007 -----QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2061
Query: 411 QAEMELKEEEAARQRQRIK-----ELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEE 465
+ E + ++ +Q Q + E E ++ +EA + V+A R+ AQ+R E
Sbjct: 2062 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA-----AQSRRQVE 2116
Query: 466 EEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADED 525
E E+LKQ EEQ + +AQ E+L++E Q++ QA+Q +RQ +Q AD +
Sbjct: 2117 EAERLKQSA---EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA--LRQ-KQAADAE 2170
Query: 526 VEA----AQRKLRQ 535
+E A++ LRQ
Sbjct: 2171 MEKHKKFAEQTLRQ 2184
Score = 76.6 bits (187), Expect = 6e-14
Identities = 77/302 (25%), Positives = 146/302 (48%), Gaps = 37/302 (12%)
Query: 251 EECKEKRGIIPLDAHCCVEVLPDRDGKRCMFCVKTANRTYEMSASDTRQRQ-EWTAAIQM 309
E ++++ + L + E R+ +R + ++ E + RQ + E +Q+
Sbjct: 1510 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1569
Query: 310 AIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQE 369
A+ + S +L+ KR E+ + + +EE + + QL+EE ER+ Q+ +
Sbjct: 1570 ALET---AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1626
Query: 370 AQRQAERLLQE------EEERRRSQHRELQQALEGQLREAEQARASMQAEMELK-----E 418
A+ +AER L+ E R R Q E+ Q + L +AE + +AE E + E
Sbjct: 1627 AREEAERELERWQLKANEALRLRLQAEEVAQ--QKSLAQAEAEKQKEEAEREARRRGKAE 1684
Query: 419 EEAARQRQRIK-ELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLK 477
E+A RQR+ + ELE+ +Q + Q + A ++E +R L E E+ +Q QL
Sbjct: 1685 EQAVRQRELAEQELEKQRQLAEGTAQQRLAA--EQELIR------LRAETEQGEQQRQLL 1736
Query: 478 EEQERYIER----AQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKL 533
EE+ ++R A Q+++EL+ E+A + + ++E + ++ RA+E+ + K
Sbjct: 1737 EEELARLQREAAAATQKRQELEAELA-------KVRAEMEVLLASKARAEEESRSTSEKS 1789
Query: 534 RQ 535
+Q
Sbjct: 1790 KQ 1791
Score = 74.3 bits (181), Expect = 3e-13
Identities = 81/293 (27%), Positives = 141/293 (48%), Gaps = 38/293 (12%)
Query: 284 KTANRTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQ---KRREQREQRERRR 340
+ A R + RQR+ ++ +L AEG +Q + R + EQ E++R
Sbjct: 1675 REARRRGKAEEQAVRQRELAEQELEKQRQL-AEGTAQQRLAAEQELIRLRAETEQGEQQR 1733
Query: 341 AAKEEELLRLQQLQEEKERKLQELEL-LQEAQRQAERLLQEE---EERRRSQHRELQQAL 396
EEEL RLQ+ +K QELE L + + + E LL + EE RS + +Q L
Sbjct: 1734 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1793
Query: 397 E---GQLRE-----------AEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEAL 442
E G+ RE AE+A+ Q L EE+AARQR E ++ L E L
Sbjct: 1794 EAEAGRFRELAEEAARLRALAEEAKRQRQ----LAEEDAARQR------AEAERVLAEKL 1843
Query: 443 QLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYI-ERAQQEKEELQQEMAQQ 501
+A R + IA + E E E+L++L + + Q R + E+A Q K ++++ +AQ
Sbjct: 1844 AAIGEATRLKTEAEIA-LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1902
Query: 502 SRS----LQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRL 550
++ L++ + +E+ + R++ +E++ A + +A+ +++ R+
Sbjct: 1903 RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1955
Score = 62.8 bits (151), Expect = 9e-10
Identities = 76/303 (25%), Positives = 138/303 (45%), Gaps = 61/303 (20%)
Query: 296 DTRQRQEWTAAIQMA----IRLQAEGKTSLHKDLKQKRRE----QREQRERRRAAKEEEL 347
D R+RQE A+ +A +R Q + +L +++++ + QR ++ A K+ EL
Sbjct: 1229 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYEL 1288
Query: 348 ---------------LRLQQLQEEKERKLQELELLQEAQRQ------------AERLLQE 380
+ ++Q E +QE L+ + +E L +
Sbjct: 1289 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1348
Query: 381 EEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQE 440
EEE R ++ QQ E + R AE A+++ + +L E A + Q +E +E+QQR+QE
Sbjct: 1349 EEEERLAE----QQRAEERERLAE-VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE 1403
Query: 441 ALQLEVKARRDEESVRI-AQTRLLEEEEEKLKQL----MQLKEEQERYIERAQQEKEE-- 493
+ RR+E +V Q R ++EE ++L+Q +Q K Q ER++ EE
Sbjct: 1404 EV-----VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1458
Query: 494 ----LQQEMAQQSR-----SLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWN 544
LQ E ++ R LQ + + EE +++A E+ E +R+++ S +
Sbjct: 1459 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1518
Query: 545 VQM 547
V++
Sbjct: 1519 VEL 1521
Score = 45.1 bits (105), Expect = 2e-04
Identities = 45/154 (29%), Positives = 72/154 (46%), Gaps = 12/154 (7%)
Query: 336 RERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQA 395
R AK+E L + E KE+K++EL Q +RLL+E+ R + Q A
Sbjct: 651 RNTNMTAKKESYSALMRELELKEKKIKEL------QNAGDRLLREDHPARPTV-ESFQAA 703
Query: 396 LEGQLREAEQARASMQAEMELKEEEAARQ-RQRIKELEEMQQRLQEALQLEVKARRDEES 454
L+ Q Q ++A LKE A Q ++E E Q+LQEAL+ + R
Sbjct: 704 LQTQWSWMLQLCCCIEA--HLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 761
Query: 455 VRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQ 488
R+ LL++ +++ +QL + K +RA+
Sbjct: 762 TRLED--LLQDAQDEKEQLNEYKGHLSGLAKRAK 793
Score = 38.9 bits (89), Expect = 0.015
Identities = 68/281 (24%), Positives = 125/281 (44%), Gaps = 44/281 (15%)
Query: 274 RDGKRCMFCV-KTANRTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQ 332
++ RC C+ + + ++ A +TR ++ + L E + + ++++ Q
Sbjct: 981 QEESRCQRCISELKDIRLQLEACETR------TVHRLRLPLDKEPARECAQRIAEQQKAQ 1034
Query: 333 RE-----QRERRRAAKEEELLRLQQ-------LQEEKERKLQELELLQEAQR-QAERLLQ 379
E + R +A+ E++L L + L+ E E L +LE ++ E+L
Sbjct: 1035 AEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKT 1094
Query: 380 EEEERRRSQH-RELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRL 438
R +Q E+ +A E QL+EA+ A++ EL+ +A+ ++ R +
Sbjct: 1095 ISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP---ELEATKASLKKLRAQA-------- 1143
Query: 439 QEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKE-EQERYIERAQQEKEELQQE 497
EA Q A RDE R +E E+L+Q ++ E ER+ ER Q E Q
Sbjct: 1144 -EAQQPTFDALRDE-------LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAV 1195
Query: 498 MAQ---QSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQ 535
+AQ + R L+Q +QL R++ ++ A+R+ Q
Sbjct: 1196 LAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1236
Score = 38.5 bits (88), Expect = 0.019
Identities = 59/265 (22%), Positives = 117/265 (44%), Gaps = 36/265 (13%)
Query: 312 RLQAE---GKTSLHKDLKQKRREQREQRERR--RAAKEEELLRLQQLQEEKERKLQELEL 366
RL AE G S H + EQ Q E R R E + +RLQ L+ + R + L L
Sbjct: 955 RLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQ-LEACETRTVHRLRL 1013
Query: 367 ---LQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARA---------SMQAEM 414
+ A+ A+R+ E+++ +++ L + + EAE+ A ++++E+
Sbjct: 1014 PLDKEPARECAQRIA--EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL 1071
Query: 415 ELK----EEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQT-----RLLEE 465
EL E+ + +++L+ + ++ E R EE ++ AQ LE
Sbjct: 1072 ELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1131
Query: 466 EEEKLKQLMQLKEEQERYIER-------AQQEKEELQQEMAQQSRSLQQAQQQLEEVRQN 518
+ LK+L E Q+ + AQ+ E LQQ ++ +++ ++++ ++ +
Sbjct: 1132 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1191
Query: 519 RQRADEDVEAAQRKLRQASTNVKHW 543
Q + QR+L Q ++++
Sbjct: 1192 WQAVLAQTDVRQRELEQLGRQLRYY 1216
Score = 37.4 bits (85), Expect = 0.042
Identities = 45/184 (24%), Positives = 80/184 (43%), Gaps = 17/184 (9%)
Query: 342 AKEEELLRLQQLQ------EEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQA 395
A EE+L Q + E + L++L EAQ+ L++E + LQQ
Sbjct: 1111 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1170
Query: 396 LEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLE-------VKA 448
+ E E+ R + +E + A+ R +ELE++ ++L+ + A
Sbjct: 1171 HGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA 1230
Query: 449 RRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQA 508
RR +E ++ + E+L+Q L EE ER+ E+ EE Q+ Q +++
Sbjct: 1231 RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKV----EECQRFAKQYINAIKDY 1286
Query: 509 QQQL 512
+ QL
Sbjct: 1287 ELQL 1290
Score = 31.2 bits (69), Expect = 3.0
Identities = 47/203 (23%), Positives = 84/203 (41%), Gaps = 20/203 (9%)
Query: 339 RRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEG 398
R E RL+ LQ + E L +E QA+ LLQ + R + + Q+A E
Sbjct: 384 REKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQ-SDVRLLAAGKVPQRAGEV 442
Query: 399 QLREAEQARA-------SMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRD 451
+ R+ ++A + +Q + + + + +R+ L E ++ L +KA
Sbjct: 443 E-RDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVA 501
Query: 452 EESVRIAQTRLL------EEEEEKLKQLMQL---KEEQERYIERAQQEKEELQQEMAQQS 502
+ ++AQ L E E+ L+ L L EE + ++ A+ + + Q
Sbjct: 502 APATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVD--LPSVEAQL 559
Query: 503 RSLQQAQQQLEEVRQNRQRADED 525
S + Q +EE R +RA D
Sbjct: 560 GSHRGLHQSIEEFRAKIERARSD 582
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 92.4 bits (228), Expect = 1e-18
Identities = 77/291 (26%), Positives = 144/291 (49%), Gaps = 34/291 (11%)
Query: 291 EMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQ-RERRRAAKEEELLR 349
E + + RQ QE ++ ++ +++ K +L + + + E RE++RA + E LR
Sbjct: 1483 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1542
Query: 350 LQQLQEEKERKLQELEL---------LQEAQRQAERLLQEEEERRRSQHRELQQALE--- 397
LQ EE ER+L++ E+ L+ AQR AE LQ + + +L+++L+
Sbjct: 1543 LQA--EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEH 1600
Query: 398 ---GQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEES 454
QLRE + RA QAE E EEA R ELE Q + EAL+L ++A +
Sbjct: 1601 VAVAQLREEAERRAQQQAEAERAREEAER------ELERWQLKANEALRLRLQAEEVAQQ 1654
Query: 455 VRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQ---AQQQ 511
+AQ +++EE ++ + + +E+ + + + ++EL+++ + QQ A+Q+
Sbjct: 1655 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1714
Query: 512 L-------EEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRLMHPIE 555
L E+ Q RQ +E++ QR+ A+ + ++ ++ +E
Sbjct: 1715 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1765
Score = 87.0 bits (214), Expect = 5e-17
Identities = 76/268 (28%), Positives = 133/268 (49%), Gaps = 26/268 (9%)
Query: 288 RTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQR-------ERRR 340
R E +A +E A ++ A + E + L +D ++RR+ E+ E+
Sbjct: 1879 RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1938
Query: 341 AAKEE---ELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALE 397
A K E EL R++ E+ R ++ EL QRQ L EEE RRR +Q++L
Sbjct: 1939 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ---LAAEEERRRREAEERVQKSLA 1995
Query: 398 GQLREAEQARASMQ--AEMELKEEEAARQRQR-----IKELEEMQQRLQEALQLEVKARR 450
+ A Q +A+++ ++ K EEA R R+R ++L+ Q+ Q+ LQ E KA
Sbjct: 1996 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2055
Query: 451 ---DEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQ 507
++ + QT L++E+ L QL E R E A++ + + ++E AQ R +++
Sbjct: 2056 FAVQQKEQELQQT--LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2113
Query: 508 AQQQLEEVRQNRQRADEDVEAAQRKLRQ 535
A ++L++ + + +A +AA KLR+
Sbjct: 2114 A-ERLKQSAEEQAQARAQAQAAAEKLRK 2140
Score = 86.7 bits (213), Expect = 6e-17
Identities = 75/282 (26%), Positives = 136/282 (48%), Gaps = 27/282 (9%)
Query: 286 ANRTYEMSASDTRQRQEWTAAIQMAIRLQAEG----KTSLHK--DLKQKRREQREQRERR 339
A R +++A + R+R+E +Q ++ + E K +L + LK K E R RER
Sbjct: 1969 AARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRER- 2027
Query: 340 RAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQ 399
A++E +LQ QE +++LQ A+ +A +++E+ Q + +Q++ Q
Sbjct: 2028 --AEQESARQLQLAQEAAQKRLQ-------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2078
Query: 400 LR-EAEQARASMQAEMELK---EEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESV 455
LR EAE AR + + E + E EAA+ R++++E E ++Q +E Q +A+ E +
Sbjct: 2079 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2138
Query: 456 R----IAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQ---EKEELQQEMAQQSRSLQQA 508
R R + E+ L+Q E E++ + A+Q +K +++QE+ L++
Sbjct: 2139 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2198
Query: 509 QQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRL 550
Q + + QR + A R+ Q + VQM L
Sbjct: 2199 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2240
Score = 84.3 bits (207), Expect = 3e-16
Identities = 98/385 (25%), Positives = 178/385 (46%), Gaps = 54/385 (14%)
Query: 288 RTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRR-EQREQRERRRAAKEEE 346
R + A +Q E A + +A + A + +DL Q+R ++ +E+ +A +E
Sbjct: 2264 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2323
Query: 347 LLRLQQ--LQEEKERKLQELELLQEAQRQ-AERLLQEEEERRRSQHRELQQALEG----- 398
L+ + LQ++KE ++ LQE + Q A++L +E + +R+ E Q+ LE
Sbjct: 2324 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2383
Query: 399 --QLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEV---------K 447
+LR AE +RA +AE E+A R R++ +E+ E R + A Q +V +
Sbjct: 2384 RLKLRVAEMSRAQARAE-----EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQR 2438
Query: 448 ARRDEESVRIAQT-RLLEEEEEKLKQ---LMQLKEEQERYIERAQ--QEKEELQQ----- 496
+ D ++ R+ + LE E+EKL+Q L+QLK E+ + +++ Q QE + LQQ
Sbjct: 2439 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2498
Query: 497 --EMAQQSRSLQQAQQQLEEVRQNR----QRADEDVEAAQRKLRQASTNVKHWNVQMNRL 550
+ Q+ R ++Q + +LE++ Q+ Q+ E+ + Q+++ Q + + R
Sbjct: 2499 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRR 2558
Query: 551 MHPIEPGDKRPVTS----SSFSGFQPPLLAHRDSSLKRLTRWGSQGNRTPSPNSNEQQKS 606
H E G +R Q LLA + L+ + + +R +S E S
Sbjct: 2559 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2618
Query: 607 L--------NGGDEAPAPASTPQED 623
NG D PA+ + +
Sbjct: 2619 QVAATKTLPNGRDALDGPAAEAEPE 2643
Score = 82.8 bits (203), Expect = 9e-16
Identities = 80/306 (26%), Positives = 140/306 (45%), Gaps = 37/306 (12%)
Query: 291 EMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRL 350
E A+ +R++ E ++ + QA+ + +K R++ EQ RRA E+ LR
Sbjct: 2101 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQA-AAEKLRKEAEQEAARRAQAEQAALRQ 2159
Query: 351 QQLQE---EKERKLQELELLQEAQRQAE----RLLQEEEERRRSQHRELQQALEGQLREA 403
+Q + EK +K E L Q+AQ + E RL EE + +++ E Q L+ + EA
Sbjct: 2160 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2219
Query: 404 EQARASMQAEM---ELKEEEAARQRQRIK--------------------ELEEMQQRLQE 440
+ R+ ++ E+ ++ EE ++ + RI+ E E+M+Q +E
Sbjct: 2220 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2279
Query: 441 ALQLEVKARRDEESVRIAQTRLLEEE---EEKLKQLMQLKEEQERY---IERAQQEKEEL 494
A +L V A+ ++A+ L ++ E+ LK+ MQ +E R E QQ+KE
Sbjct: 2280 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA 2339
Query: 495 QQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRLMHPI 554
Q++ + +Q QQL E Q QR E Q ++ + +K +M+R
Sbjct: 2340 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2399
Query: 555 EPGDKR 560
E +R
Sbjct: 2400 EEDAQR 2405
Score = 81.6 bits (200), Expect = 2e-15
Identities = 75/298 (25%), Positives = 139/298 (46%), Gaps = 38/298 (12%)
Query: 288 RTYEMSASDTRQR-QEWTAAIQMAIRL---QAEGKTSLHKDLKQKRREQREQRERRRAAK 343
R E ++ R+R E AA++ +L A+ K ++ K+ ++ +E+ RR
Sbjct: 1349 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR---- 1404
Query: 344 EEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREA 403
EE + QQ + + +LQ+L EA+ QA+ E ER R + E + + QL
Sbjct: 1405 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1464
Query: 404 EQARASMQAEMEL----KEEEAARQRQRIKELEEMQQRLQEALQ--------------LE 445
E+ R + E++ EE A++RQ +E E +++++Q+ Q E
Sbjct: 1465 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1524
Query: 446 VKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYI----ERAQQEKE-ELQ----- 495
+A R+++ A L + EE ++L Q + E+ R + E AQ+ E ELQ
Sbjct: 1525 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1584
Query: 496 --QEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRLM 551
++ AQ RSLQ+ + ++R+ +R + A+R +A ++ W ++ N +
Sbjct: 1585 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1642
Score = 80.1 bits (196), Expect = 6e-15
Identities = 65/220 (29%), Positives = 109/220 (49%), Gaps = 23/220 (10%)
Query: 337 ERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQAL 396
E R +EEE L QQ EE+ER L E+E E QRQ + + + + +ELQQ +
Sbjct: 1339 ETLRRMEEEERLAEQQRAEERER-LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1397
Query: 397 EGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVR 456
+ ++ E+A Q + +EE + RQ + E+Q + ++A E R EE +R
Sbjct: 1398 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA--EIQAKARQAEAAERSRLRIEEEIR 1455
Query: 457 IAQTRLLEEEEEK------LKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQ 510
+ + +L E ++ L+ L EE E +AQ+E E L++++ +S+ +QA+
Sbjct: 1456 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1515
Query: 511 QLE-------EVRQNRQRADE-------DVEAAQRKLRQA 536
+L E + +QRA + E A+R+LRQA
Sbjct: 1516 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQA 1555
Score = 78.2 bits (191), Expect = 2e-14
Identities = 84/330 (25%), Positives = 153/330 (46%), Gaps = 58/330 (17%)
Query: 275 DGKRCMFCVKTANRTYEMSASDT-RQRQEWTAAIQMAIRLQAEGK-TSLHKDLKQKRREQ 332
+ R + A R +++ D RQR E A +A +L A G+ T L + + +E+
Sbjct: 1802 EAARLRALAEEAKRQRQLAEEDAARQRAE--AERVLAEKLAAIGEATRLKTEAEIALKEK 1859
Query: 333 REQRERRRAAKEEELLRLQQLQEEK-------ERKLQELELLQEAQRQAERLLQEEEERR 385
+ ER R E+E + ++L+E+ E +L +L +++ + ++ L E+ R+
Sbjct: 1860 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 1919
Query: 386 RSQHRELQQALEGQLREAEQARASMQAEM--------------ELKEEEAARQRQRIKEL 431
R Q E AL+ +A +A ++ E+ E E EAARQRQ E
Sbjct: 1920 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1979
Query: 432 E----EMQQRLQEALQLEVKARRDEESV---------RIAQTRLLEE--EEEKLKQLM-- 474
E E ++R+Q++L E +A R ++ ++ + R L E E+E +QL
Sbjct: 1980 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2039
Query: 475 ------QLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVR---QNRQRADED 525
+L+ E++ + QQ+++ELQQ +LQQ Q L+++R + +RA E+
Sbjct: 2040 QEAAQKRLQAEEKAHAFAVQQKEQELQQ-------TLQQEQSVLDQLRGEAEAARRAAEE 2092
Query: 526 VEAAQRKLRQASTNVKHWNVQMNRLMHPIE 555
E A+ + + + + + RL E
Sbjct: 2093 AEEARVQAEREAAQSRRQVEEAERLKQSAE 2122
Score = 78.2 bits (191), Expect = 2e-14
Identities = 72/254 (28%), Positives = 127/254 (50%), Gaps = 27/254 (10%)
Query: 291 EMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRL 350
E+ R E T + L+A + L + +++RR + E+R ++ A EEE R
Sbjct: 1945 ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE-EERRRREAEERVQKSLAAEEEAAR- 2002
Query: 351 QQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASM 410
+++ L+E+E L+ +A RL + E+ Q + Q+A + +L+ E+A A
Sbjct: 2003 -----QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2057
Query: 411 QAEMELKEEEAARQRQRIK-----ELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEE 465
+ E + ++ +Q Q + E E ++ +EA + V+A R+ AQ+R E
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA-----AQSRRQVE 2112
Query: 466 EEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADED 525
E E+LKQ EEQ + +AQ E+L++E Q++ QA+Q +RQ +Q AD +
Sbjct: 2113 EAERLKQSA---EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA--LRQ-KQAADAE 2166
Query: 526 VEA----AQRKLRQ 535
+E A++ LRQ
Sbjct: 2167 MEKHKKFAEQTLRQ 2180
Score = 76.6 bits (187), Expect = 6e-14
Identities = 77/302 (25%), Positives = 146/302 (48%), Gaps = 37/302 (12%)
Query: 251 EECKEKRGIIPLDAHCCVEVLPDRDGKRCMFCVKTANRTYEMSASDTRQRQ-EWTAAIQM 309
E ++++ + L + E R+ +R + ++ E + RQ + E +Q+
Sbjct: 1506 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1565
Query: 310 AIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQE 369
A+ + S +L+ KR E+ + + +EE + + QL+EE ER+ Q+ +
Sbjct: 1566 ALET---AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1622
Query: 370 AQRQAERLLQE------EEERRRSQHRELQQALEGQLREAEQARASMQAEMELK-----E 418
A+ +AER L+ E R R Q E+ Q + L +AE + +AE E + E
Sbjct: 1623 AREEAERELERWQLKANEALRLRLQAEEVAQ--QKSLAQAEAEKQKEEAEREARRRGKAE 1680
Query: 419 EEAARQRQRIK-ELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLK 477
E+A RQR+ + ELE+ +Q + Q + A ++E +R L E E+ +Q QL
Sbjct: 1681 EQAVRQRELAEQELEKQRQLAEGTAQQRLAA--EQELIR------LRAETEQGEQQRQLL 1732
Query: 478 EEQERYIER----AQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKL 533
EE+ ++R A Q+++EL+ E+A + + ++E + ++ RA+E+ + K
Sbjct: 1733 EEELARLQREAAAATQKRQELEAELA-------KVRAEMEVLLASKARAEEESRSTSEKS 1785
Query: 534 RQ 535
+Q
Sbjct: 1786 KQ 1787
Score = 74.3 bits (181), Expect = 3e-13
Identities = 81/293 (27%), Positives = 141/293 (48%), Gaps = 38/293 (12%)
Query: 284 KTANRTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQ---KRREQREQRERRR 340
+ A R + RQR+ ++ +L AEG +Q + R + EQ E++R
Sbjct: 1671 REARRRGKAEEQAVRQRELAEQELEKQRQL-AEGTAQQRLAAEQELIRLRAETEQGEQQR 1729
Query: 341 AAKEEELLRLQQLQEEKERKLQELEL-LQEAQRQAERLLQEE---EERRRSQHRELQQAL 396
EEEL RLQ+ +K QELE L + + + E LL + EE RS + +Q L
Sbjct: 1730 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1789
Query: 397 E---GQLRE-----------AEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEAL 442
E G+ RE AE+A+ Q L EE+AARQR E ++ L E L
Sbjct: 1790 EAEAGRFRELAEEAARLRALAEEAKRQRQ----LAEEDAARQR------AEAERVLAEKL 1839
Query: 443 QLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYI-ERAQQEKEELQQEMAQQ 501
+A R + IA + E E E+L++L + + Q R + E+A Q K ++++ +AQ
Sbjct: 1840 AAIGEATRLKTEAEIA-LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1898
Query: 502 SRS----LQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRL 550
++ L++ + +E+ + R++ +E++ A + +A+ +++ R+
Sbjct: 1899 RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1951
Score = 62.8 bits (151), Expect = 9e-10
Identities = 76/303 (25%), Positives = 138/303 (45%), Gaps = 61/303 (20%)
Query: 296 DTRQRQEWTAAIQMA----IRLQAEGKTSLHKDLKQKRRE----QREQRERRRAAKEEEL 347
D R+RQE A+ +A +R Q + +L +++++ + QR ++ A K+ EL
Sbjct: 1225 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYEL 1284
Query: 348 ---------------LRLQQLQEEKERKLQELELLQEAQRQ------------AERLLQE 380
+ ++Q E +QE L+ + +E L +
Sbjct: 1285 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1344
Query: 381 EEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQE 440
EEE R ++ QQ E + R AE A+++ + +L E A + Q +E +E+QQR+QE
Sbjct: 1345 EEEERLAE----QQRAEERERLAE-VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE 1399
Query: 441 ALQLEVKARRDEESVRI-AQTRLLEEEEEKLKQL----MQLKEEQERYIERAQQEKEE-- 493
+ RR+E +V Q R ++EE ++L+Q +Q K Q ER++ EE
Sbjct: 1400 EV-----VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1454
Query: 494 ----LQQEMAQQSR-----SLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWN 544
LQ E ++ R LQ + + EE +++A E+ E +R+++ S +
Sbjct: 1455 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1514
Query: 545 VQM 547
V++
Sbjct: 1515 VEL 1517
Score = 45.1 bits (105), Expect = 2e-04
Identities = 45/154 (29%), Positives = 72/154 (46%), Gaps = 12/154 (7%)
Query: 336 RERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQA 395
R AK+E L + E KE+K++EL Q +RLL+E+ R + Q A
Sbjct: 647 RNTNMTAKKESYSALMRELELKEKKIKEL------QNAGDRLLREDHPARPTV-ESFQAA 699
Query: 396 LEGQLREAEQARASMQAEMELKEEEAARQ-RQRIKELEEMQQRLQEALQLEVKARRDEES 454
L+ Q Q ++A LKE A Q ++E E Q+LQEAL+ + R
Sbjct: 700 LQTQWSWMLQLCCCIEA--HLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 757
Query: 455 VRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQ 488
R+ LL++ +++ +QL + K +RA+
Sbjct: 758 TRLED--LLQDAQDEKEQLNEYKGHLSGLAKRAK 789
Score = 38.9 bits (89), Expect = 0.015
Identities = 68/281 (24%), Positives = 125/281 (44%), Gaps = 44/281 (15%)
Query: 274 RDGKRCMFCV-KTANRTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQ 332
++ RC C+ + + ++ A +TR ++ + L E + + ++++ Q
Sbjct: 977 QEESRCQRCISELKDIRLQLEACETR------TVHRLRLPLDKEPARECAQRIAEQQKAQ 1030
Query: 333 RE-----QRERRRAAKEEELLRLQQ-------LQEEKERKLQELELLQEAQR-QAERLLQ 379
E + R +A+ E++L L + L+ E E L +LE ++ E+L
Sbjct: 1031 AEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKT 1090
Query: 380 EEEERRRSQH-RELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRL 438
R +Q E+ +A E QL+EA+ A++ EL+ +A+ ++ R +
Sbjct: 1091 ISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP---ELEATKASLKKLRAQA-------- 1139
Query: 439 QEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKE-EQERYIERAQQEKEELQQE 497
EA Q A RDE R +E E+L+Q ++ E ER+ ER Q E Q
Sbjct: 1140 -EAQQPTFDALRDE-------LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAV 1191
Query: 498 MAQ---QSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQ 535
+AQ + R L+Q +QL R++ ++ A+R+ Q
Sbjct: 1192 LAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1232
Score = 38.5 bits (88), Expect = 0.019
Identities = 59/265 (22%), Positives = 117/265 (44%), Gaps = 36/265 (13%)
Query: 312 RLQAE---GKTSLHKDLKQKRREQREQRERR--RAAKEEELLRLQQLQEEKERKLQELEL 366
RL AE G S H + EQ Q E R R E + +RLQ L+ + R + L L
Sbjct: 951 RLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQ-LEACETRTVHRLRL 1009
Query: 367 ---LQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARA---------SMQAEM 414
+ A+ A+R+ E+++ +++ L + + EAE+ A ++++E+
Sbjct: 1010 PLDKEPARECAQRIA--EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL 1067
Query: 415 ELK----EEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQT-----RLLEE 465
EL E+ + +++L+ + ++ E R EE ++ AQ LE
Sbjct: 1068 ELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1127
Query: 466 EEEKLKQLMQLKEEQERYIER-------AQQEKEELQQEMAQQSRSLQQAQQQLEEVRQN 518
+ LK+L E Q+ + AQ+ E LQQ ++ +++ ++++ ++ +
Sbjct: 1128 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1187
Query: 519 RQRADEDVEAAQRKLRQASTNVKHW 543
Q + QR+L Q ++++
Sbjct: 1188 WQAVLAQTDVRQRELEQLGRQLRYY 1212
Score = 37.4 bits (85), Expect = 0.042
Identities = 45/184 (24%), Positives = 80/184 (43%), Gaps = 17/184 (9%)
Query: 342 AKEEELLRLQQLQ------EEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQA 395
A EE+L Q + E + L++L EAQ+ L++E + LQQ
Sbjct: 1107 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1166
Query: 396 LEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLE-------VKA 448
+ E E+ R + +E + A+ R +ELE++ ++L+ + A
Sbjct: 1167 HGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA 1226
Query: 449 RRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQA 508
RR +E ++ + E+L+Q L EE ER+ E+ EE Q+ Q +++
Sbjct: 1227 RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKV----EECQRFAKQYINAIKDY 1282
Query: 509 QQQL 512
+ QL
Sbjct: 1283 ELQL 1286
Score = 31.2 bits (69), Expect = 3.0
Identities = 47/203 (23%), Positives = 84/203 (41%), Gaps = 20/203 (9%)
Query: 339 RRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEG 398
R E RL+ LQ + E L +E QA+ LLQ + R + + Q+A E
Sbjct: 380 REKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQ-SDVRLLAAGKVPQRAGEV 438
Query: 399 QLREAEQARA-------SMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRD 451
+ R+ ++A + +Q + + + + +R+ L E ++ L +KA
Sbjct: 439 E-RDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVA 497
Query: 452 EESVRIAQTRLL------EEEEEKLKQLMQL---KEEQERYIERAQQEKEELQQEMAQQS 502
+ ++AQ L E E+ L+ L L EE + ++ A+ + + Q
Sbjct: 498 APATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVD--LPSVEAQL 555
Query: 503 RSLQQAQQQLEEVRQNRQRADED 525
S + Q +EE R +RA D
Sbjct: 556 GSHRGLHQSIEEFRAKIERARSD 578
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 92.4 bits (228), Expect = 1e-18
Identities = 77/291 (26%), Positives = 144/291 (49%), Gaps = 34/291 (11%)
Query: 291 EMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQ-RERRRAAKEEELLR 349
E + + RQ QE ++ ++ +++ K +L + + + E RE++RA + E LR
Sbjct: 1451 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1510
Query: 350 LQQLQEEKERKLQELEL---------LQEAQRQAERLLQEEEERRRSQHRELQQALE--- 397
LQ EE ER+L++ E+ L+ AQR AE LQ + + +L+++L+
Sbjct: 1511 LQA--EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEH 1568
Query: 398 ---GQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEES 454
QLRE + RA QAE E EEA R ELE Q + EAL+L ++A +
Sbjct: 1569 VAVAQLREEAERRAQQQAEAERAREEAER------ELERWQLKANEALRLRLQAEEVAQQ 1622
Query: 455 VRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQ---AQQQ 511
+AQ +++EE ++ + + +E+ + + + ++EL+++ + QQ A+Q+
Sbjct: 1623 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1682
Query: 512 L-------EEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRLMHPIE 555
L E+ Q RQ +E++ QR+ A+ + ++ ++ +E
Sbjct: 1683 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1733
Score = 87.0 bits (214), Expect = 5e-17
Identities = 76/268 (28%), Positives = 133/268 (49%), Gaps = 26/268 (9%)
Query: 288 RTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQR-------ERRR 340
R E +A +E A ++ A + E + L +D ++RR+ E+ E+
Sbjct: 1847 RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1906
Query: 341 AAKEE---ELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALE 397
A K E EL R++ E+ R ++ EL QRQ L EEE RRR +Q++L
Sbjct: 1907 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ---LAAEEERRRREAEERVQKSLA 1963
Query: 398 GQLREAEQARASMQ--AEMELKEEEAARQRQR-----IKELEEMQQRLQEALQLEVKARR 450
+ A Q +A+++ ++ K EEA R R+R ++L+ Q+ Q+ LQ E KA
Sbjct: 1964 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2023
Query: 451 ---DEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQ 507
++ + QT L++E+ L QL E R E A++ + + ++E AQ R +++
Sbjct: 2024 FAVQQKEQELQQT--LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2081
Query: 508 AQQQLEEVRQNRQRADEDVEAAQRKLRQ 535
A ++L++ + + +A +AA KLR+
Sbjct: 2082 A-ERLKQSAEEQAQARAQAQAAAEKLRK 2108
Score = 86.7 bits (213), Expect = 6e-17
Identities = 75/282 (26%), Positives = 136/282 (48%), Gaps = 27/282 (9%)
Query: 286 ANRTYEMSASDTRQRQEWTAAIQMAIRLQAEG----KTSLHK--DLKQKRREQREQRERR 339
A R +++A + R+R+E +Q ++ + E K +L + LK K E R RER
Sbjct: 1937 AARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRER- 1995
Query: 340 RAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQ 399
A++E +LQ QE +++LQ A+ +A +++E+ Q + +Q++ Q
Sbjct: 1996 --AEQESARQLQLAQEAAQKRLQ-------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2046
Query: 400 LR-EAEQARASMQAEMELK---EEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESV 455
LR EAE AR + + E + E EAA+ R++++E E ++Q +E Q +A+ E +
Sbjct: 2047 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2106
Query: 456 R----IAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQ---EKEELQQEMAQQSRSLQQA 508
R R + E+ L+Q E E++ + A+Q +K +++QE+ L++
Sbjct: 2107 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2166
Query: 509 QQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRL 550
Q + + QR + A R+ Q + VQM L
Sbjct: 2167 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2208
Score = 84.3 bits (207), Expect = 3e-16
Identities = 98/385 (25%), Positives = 178/385 (46%), Gaps = 54/385 (14%)
Query: 288 RTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRR-EQREQRERRRAAKEEE 346
R + A +Q E A + +A + A + +DL Q+R ++ +E+ +A +E
Sbjct: 2232 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2291
Query: 347 LLRLQQ--LQEEKERKLQELELLQEAQRQ-AERLLQEEEERRRSQHRELQQALEG----- 398
L+ + LQ++KE ++ LQE + Q A++L +E + +R+ E Q+ LE
Sbjct: 2292 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2351
Query: 399 --QLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEV---------K 447
+LR AE +RA +AE E+A R R++ +E+ E R + A Q +V +
Sbjct: 2352 RLKLRVAEMSRAQARAE-----EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQR 2406
Query: 448 ARRDEESVRIAQT-RLLEEEEEKLKQ---LMQLKEEQERYIERAQ--QEKEELQQ----- 496
+ D ++ R+ + LE E+EKL+Q L+QLK E+ + +++ Q QE + LQQ
Sbjct: 2407 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2466
Query: 497 --EMAQQSRSLQQAQQQLEEVRQNR----QRADEDVEAAQRKLRQASTNVKHWNVQMNRL 550
+ Q+ R ++Q + +LE++ Q+ Q+ E+ + Q+++ Q + + R
Sbjct: 2467 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRR 2526
Query: 551 MHPIEPGDKRPVTS----SSFSGFQPPLLAHRDSSLKRLTRWGSQGNRTPSPNSNEQQKS 606
H E G +R Q LLA + L+ + + +R +S E S
Sbjct: 2527 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2586
Query: 607 L--------NGGDEAPAPASTPQED 623
NG D PA+ + +
Sbjct: 2587 QVAATKTLPNGRDALDGPAAEAEPE 2611
Score = 82.8 bits (203), Expect = 9e-16
Identities = 80/306 (26%), Positives = 140/306 (45%), Gaps = 37/306 (12%)
Query: 291 EMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRL 350
E A+ +R++ E ++ + QA+ + +K R++ EQ RRA E+ LR
Sbjct: 2069 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQA-AAEKLRKEAEQEAARRAQAEQAALRQ 2127
Query: 351 QQLQE---EKERKLQELELLQEAQRQAE----RLLQEEEERRRSQHRELQQALEGQLREA 403
+Q + EK +K E L Q+AQ + E RL EE + +++ E Q L+ + EA
Sbjct: 2128 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2187
Query: 404 EQARASMQAEM---ELKEEEAARQRQRIK--------------------ELEEMQQRLQE 440
+ R+ ++ E+ ++ EE ++ + RI+ E E+M+Q +E
Sbjct: 2188 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2247
Query: 441 ALQLEVKARRDEESVRIAQTRLLEEE---EEKLKQLMQLKEEQERY---IERAQQEKEEL 494
A +L V A+ ++A+ L ++ E+ LK+ MQ +E R E QQ+KE
Sbjct: 2248 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA 2307
Query: 495 QQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRLMHPI 554
Q++ + +Q QQL E Q QR E Q ++ + +K +M+R
Sbjct: 2308 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2367
Query: 555 EPGDKR 560
E +R
Sbjct: 2368 EEDAQR 2373
Score = 81.6 bits (200), Expect = 2e-15
Identities = 75/298 (25%), Positives = 139/298 (46%), Gaps = 38/298 (12%)
Query: 288 RTYEMSASDTRQR-QEWTAAIQMAIRL---QAEGKTSLHKDLKQKRREQREQRERRRAAK 343
R E ++ R+R E AA++ +L A+ K ++ K+ ++ +E+ RR
Sbjct: 1317 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR---- 1372
Query: 344 EEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREA 403
EE + QQ + + +LQ+L EA+ QA+ E ER R + E + + QL
Sbjct: 1373 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1432
Query: 404 EQARASMQAEMEL----KEEEAARQRQRIKELEEMQQRLQEALQ--------------LE 445
E+ R + E++ EE A++RQ +E E +++++Q+ Q E
Sbjct: 1433 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1492
Query: 446 VKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYI----ERAQQEKE-ELQ----- 495
+A R+++ A L + EE ++L Q + E+ R + E AQ+ E ELQ
Sbjct: 1493 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1552
Query: 496 --QEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRLM 551
++ AQ RSLQ+ + ++R+ +R + A+R +A ++ W ++ N +
Sbjct: 1553 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1610
Score = 80.1 bits (196), Expect = 6e-15
Identities = 65/220 (29%), Positives = 109/220 (49%), Gaps = 23/220 (10%)
Query: 337 ERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQAL 396
E R +EEE L QQ EE+ER L E+E E QRQ + + + + +ELQQ +
Sbjct: 1307 ETLRRMEEEERLAEQQRAEERER-LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1365
Query: 397 EGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVR 456
+ ++ E+A Q + +EE + RQ + E+Q + ++A E R EE +R
Sbjct: 1366 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA--EIQAKARQAEAAERSRLRIEEEIR 1423
Query: 457 IAQTRLLEEEEEK------LKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQ 510
+ + +L E ++ L+ L EE E +AQ+E E L++++ +S+ +QA+
Sbjct: 1424 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1483
Query: 511 QLE-------EVRQNRQRADE-------DVEAAQRKLRQA 536
+L E + +QRA + E A+R+LRQA
Sbjct: 1484 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQA 1523
Score = 78.2 bits (191), Expect = 2e-14
Identities = 84/330 (25%), Positives = 153/330 (46%), Gaps = 58/330 (17%)
Query: 275 DGKRCMFCVKTANRTYEMSASDT-RQRQEWTAAIQMAIRLQAEGK-TSLHKDLKQKRREQ 332
+ R + A R +++ D RQR E A +A +L A G+ T L + + +E+
Sbjct: 1770 EAARLRALAEEAKRQRQLAEEDAARQRAE--AERVLAEKLAAIGEATRLKTEAEIALKEK 1827
Query: 333 REQRERRRAAKEEELLRLQQLQEEK-------ERKLQELELLQEAQRQAERLLQEEEERR 385
+ ER R E+E + ++L+E+ E +L +L +++ + ++ L E+ R+
Sbjct: 1828 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 1887
Query: 386 RSQHRELQQALEGQLREAEQARASMQAEM--------------ELKEEEAARQRQRIKEL 431
R Q E AL+ +A +A ++ E+ E E EAARQRQ E
Sbjct: 1888 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1947
Query: 432 E----EMQQRLQEALQLEVKARRDEESV---------RIAQTRLLEE--EEEKLKQLM-- 474
E E ++R+Q++L E +A R ++ ++ + R L E E+E +QL
Sbjct: 1948 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2007
Query: 475 ------QLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVR---QNRQRADED 525
+L+ E++ + QQ+++ELQQ +LQQ Q L+++R + +RA E+
Sbjct: 2008 QEAAQKRLQAEEKAHAFAVQQKEQELQQ-------TLQQEQSVLDQLRGEAEAARRAAEE 2060
Query: 526 VEAAQRKLRQASTNVKHWNVQMNRLMHPIE 555
E A+ + + + + + RL E
Sbjct: 2061 AEEARVQAEREAAQSRRQVEEAERLKQSAE 2090
Score = 78.2 bits (191), Expect = 2e-14
Identities = 72/254 (28%), Positives = 127/254 (50%), Gaps = 27/254 (10%)
Query: 291 EMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRL 350
E+ R E T + L+A + L + +++RR + E+R ++ A EEE R
Sbjct: 1913 ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE-EERRRREAEERVQKSLAAEEEAAR- 1970
Query: 351 QQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASM 410
+++ L+E+E L+ +A RL + E+ Q + Q+A + +L+ E+A A
Sbjct: 1971 -----QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2025
Query: 411 QAEMELKEEEAARQRQRIK-----ELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEE 465
+ E + ++ +Q Q + E E ++ +EA + V+A R+ AQ+R E
Sbjct: 2026 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA-----AQSRRQVE 2080
Query: 466 EEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADED 525
E E+LKQ EEQ + +AQ E+L++E Q++ QA+Q +RQ +Q AD +
Sbjct: 2081 EAERLKQSA---EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA--LRQ-KQAADAE 2134
Query: 526 VEA----AQRKLRQ 535
+E A++ LRQ
Sbjct: 2135 MEKHKKFAEQTLRQ 2148
Score = 76.6 bits (187), Expect = 6e-14
Identities = 77/302 (25%), Positives = 146/302 (48%), Gaps = 37/302 (12%)
Query: 251 EECKEKRGIIPLDAHCCVEVLPDRDGKRCMFCVKTANRTYEMSASDTRQRQ-EWTAAIQM 309
E ++++ + L + E R+ +R + ++ E + RQ + E +Q+
Sbjct: 1474 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1533
Query: 310 AIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQE 369
A+ + S +L+ KR E+ + + +EE + + QL+EE ER+ Q+ +
Sbjct: 1534 ALET---AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1590
Query: 370 AQRQAERLLQE------EEERRRSQHRELQQALEGQLREAEQARASMQAEMELK-----E 418
A+ +AER L+ E R R Q E+ Q + L +AE + +AE E + E
Sbjct: 1591 AREEAERELERWQLKANEALRLRLQAEEVAQ--QKSLAQAEAEKQKEEAEREARRRGKAE 1648
Query: 419 EEAARQRQRIK-ELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLK 477
E+A RQR+ + ELE+ +Q + Q + A ++E +R L E E+ +Q QL
Sbjct: 1649 EQAVRQRELAEQELEKQRQLAEGTAQQRLAA--EQELIR------LRAETEQGEQQRQLL 1700
Query: 478 EEQERYIER----AQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKL 533
EE+ ++R A Q+++EL+ E+A + + ++E + ++ RA+E+ + K
Sbjct: 1701 EEELARLQREAAAATQKRQELEAELA-------KVRAEMEVLLASKARAEEESRSTSEKS 1753
Query: 534 RQ 535
+Q
Sbjct: 1754 KQ 1755
Score = 74.3 bits (181), Expect = 3e-13
Identities = 81/293 (27%), Positives = 141/293 (48%), Gaps = 38/293 (12%)
Query: 284 KTANRTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQ---KRREQREQRERRR 340
+ A R + RQR+ ++ +L AEG +Q + R + EQ E++R
Sbjct: 1639 REARRRGKAEEQAVRQRELAEQELEKQRQL-AEGTAQQRLAAEQELIRLRAETEQGEQQR 1697
Query: 341 AAKEEELLRLQQLQEEKERKLQELEL-LQEAQRQAERLLQEE---EERRRSQHRELQQAL 396
EEEL RLQ+ +K QELE L + + + E LL + EE RS + +Q L
Sbjct: 1698 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1757
Query: 397 E---GQLRE-----------AEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEAL 442
E G+ RE AE+A+ Q L EE+AARQR E ++ L E L
Sbjct: 1758 EAEAGRFRELAEEAARLRALAEEAKRQRQ----LAEEDAARQR------AEAERVLAEKL 1807
Query: 443 QLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYI-ERAQQEKEELQQEMAQQ 501
+A R + IA + E E E+L++L + + Q R + E+A Q K ++++ +AQ
Sbjct: 1808 AAIGEATRLKTEAEIA-LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1866
Query: 502 SRS----LQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRL 550
++ L++ + +E+ + R++ +E++ A + +A+ +++ R+
Sbjct: 1867 RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1919
Score = 62.8 bits (151), Expect = 9e-10
Identities = 76/303 (25%), Positives = 138/303 (45%), Gaps = 61/303 (20%)
Query: 296 DTRQRQEWTAAIQMA----IRLQAEGKTSLHKDLKQKRRE----QREQRERRRAAKEEEL 347
D R+RQE A+ +A +R Q + +L +++++ + QR ++ A K+ EL
Sbjct: 1193 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYEL 1252
Query: 348 ---------------LRLQQLQEEKERKLQELELLQEAQRQ------------AERLLQE 380
+ ++Q E +QE L+ + +E L +
Sbjct: 1253 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1312
Query: 381 EEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQE 440
EEE R ++ QQ E + R AE A+++ + +L E A + Q +E +E+QQR+QE
Sbjct: 1313 EEEERLAE----QQRAEERERLAE-VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE 1367
Query: 441 ALQLEVKARRDEESVRI-AQTRLLEEEEEKLKQL----MQLKEEQERYIERAQQEKEE-- 493
+ RR+E +V Q R ++EE ++L+Q +Q K Q ER++ EE
Sbjct: 1368 EV-----VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1422
Query: 494 ----LQQEMAQQSR-----SLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWN 544
LQ E ++ R LQ + + EE +++A E+ E +R+++ S +
Sbjct: 1423 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1482
Query: 545 VQM 547
V++
Sbjct: 1483 VEL 1485
Score = 45.1 bits (105), Expect = 2e-04
Identities = 45/154 (29%), Positives = 72/154 (46%), Gaps = 12/154 (7%)
Query: 336 RERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQA 395
R AK+E L + E KE+K++EL Q +RLL+E+ R + Q A
Sbjct: 615 RNTNMTAKKESYSALMRELELKEKKIKEL------QNAGDRLLREDHPARPTV-ESFQAA 667
Query: 396 LEGQLREAEQARASMQAEMELKEEEAARQ-RQRIKELEEMQQRLQEALQLEVKARRDEES 454
L+ Q Q ++A LKE A Q ++E E Q+LQEAL+ + R
Sbjct: 668 LQTQWSWMLQLCCCIEA--HLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 725
Query: 455 VRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQ 488
R+ LL++ +++ +QL + K +RA+
Sbjct: 726 TRLED--LLQDAQDEKEQLNEYKGHLSGLAKRAK 757
Score = 38.9 bits (89), Expect = 0.015
Identities = 68/281 (24%), Positives = 125/281 (44%), Gaps = 44/281 (15%)
Query: 274 RDGKRCMFCV-KTANRTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQ 332
++ RC C+ + + ++ A +TR ++ + L E + + ++++ Q
Sbjct: 945 QEESRCQRCISELKDIRLQLEACETR------TVHRLRLPLDKEPARECAQRIAEQQKAQ 998
Query: 333 RE-----QRERRRAAKEEELLRLQQ-------LQEEKERKLQELELLQEAQR-QAERLLQ 379
E + R +A+ E++L L + L+ E E L +LE ++ E+L
Sbjct: 999 AEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKT 1058
Query: 380 EEEERRRSQH-RELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRL 438
R +Q E+ +A E QL+EA+ A++ EL+ +A+ ++ R +
Sbjct: 1059 ISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP---ELEATKASLKKLRAQA-------- 1107
Query: 439 QEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKE-EQERYIERAQQEKEELQQE 497
EA Q A RDE R +E E+L+Q ++ E ER+ ER Q E Q
Sbjct: 1108 -EAQQPTFDALRDE-------LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAV 1159
Query: 498 MAQ---QSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQ 535
+AQ + R L+Q +QL R++ ++ A+R+ Q
Sbjct: 1160 LAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1200
Score = 38.5 bits (88), Expect = 0.019
Identities = 59/265 (22%), Positives = 117/265 (44%), Gaps = 36/265 (13%)
Query: 312 RLQAE---GKTSLHKDLKQKRREQREQRERR--RAAKEEELLRLQQLQEEKERKLQELEL 366
RL AE G S H + EQ Q E R R E + +RLQ L+ + R + L L
Sbjct: 919 RLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQ-LEACETRTVHRLRL 977
Query: 367 ---LQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARA---------SMQAEM 414
+ A+ A+R+ E+++ +++ L + + EAE+ A ++++E+
Sbjct: 978 PLDKEPARECAQRIA--EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL 1035
Query: 415 ELK----EEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQT-----RLLEE 465
EL E+ + +++L+ + ++ E R EE ++ AQ LE
Sbjct: 1036 ELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1095
Query: 466 EEEKLKQLMQLKEEQERYIER-------AQQEKEELQQEMAQQSRSLQQAQQQLEEVRQN 518
+ LK+L E Q+ + AQ+ E LQQ ++ +++ ++++ ++ +
Sbjct: 1096 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1155
Query: 519 RQRADEDVEAAQRKLRQASTNVKHW 543
Q + QR+L Q ++++
Sbjct: 1156 WQAVLAQTDVRQRELEQLGRQLRYY 1180
Score = 37.4 bits (85), Expect = 0.042
Identities = 45/184 (24%), Positives = 80/184 (43%), Gaps = 17/184 (9%)
Query: 342 AKEEELLRLQQLQ------EEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQA 395
A EE+L Q + E + L++L EAQ+ L++E + LQQ
Sbjct: 1075 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1134
Query: 396 LEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLE-------VKA 448
+ E E+ R + +E + A+ R +ELE++ ++L+ + A
Sbjct: 1135 HGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA 1194
Query: 449 RRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQA 508
RR +E ++ + E+L+Q L EE ER+ E+ EE Q+ Q +++
Sbjct: 1195 RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKV----EECQRFAKQYINAIKDY 1250
Query: 509 QQQL 512
+ QL
Sbjct: 1251 ELQL 1254
Score = 31.2 bits (69), Expect = 3.0
Identities = 47/203 (23%), Positives = 84/203 (41%), Gaps = 20/203 (9%)
Query: 339 RRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEG 398
R E RL+ LQ + E L +E QA+ LLQ + R + + Q+A E
Sbjct: 348 REKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQ-SDVRLLAAGKVPQRAGEV 406
Query: 399 QLREAEQARA-------SMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRD 451
+ R+ ++A + +Q + + + + +R+ L E ++ L +KA
Sbjct: 407 E-RDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVA 465
Query: 452 EESVRIAQTRLL------EEEEEKLKQLMQL---KEEQERYIERAQQEKEELQQEMAQQS 502
+ ++AQ L E E+ L+ L L EE + ++ A+ + + Q
Sbjct: 466 APATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVD--LPSVEAQL 523
Query: 503 RSLQQAQQQLEEVRQNRQRADED 525
S + Q +EE R +RA D
Sbjct: 524 GSHRGLHQSIEEFRAKIERARSD 546
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 92.4 bits (228), Expect = 1e-18
Identities = 77/291 (26%), Positives = 144/291 (49%), Gaps = 34/291 (11%)
Query: 291 EMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQ-RERRRAAKEEELLR 349
E + + RQ QE ++ ++ +++ K +L + + + E RE++RA + E LR
Sbjct: 1620 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1679
Query: 350 LQQLQEEKERKLQELEL---------LQEAQRQAERLLQEEEERRRSQHRELQQALE--- 397
LQ EE ER+L++ E+ L+ AQR AE LQ + + +L+++L+
Sbjct: 1680 LQA--EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEH 1737
Query: 398 ---GQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEES 454
QLRE + RA QAE E EEA R ELE Q + EAL+L ++A +
Sbjct: 1738 VAVAQLREEAERRAQQQAEAERAREEAER------ELERWQLKANEALRLRLQAEEVAQQ 1791
Query: 455 VRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQ---AQQQ 511
+AQ +++EE ++ + + +E+ + + + ++EL+++ + QQ A+Q+
Sbjct: 1792 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1851
Query: 512 L-------EEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRLMHPIE 555
L E+ Q RQ +E++ QR+ A+ + ++ ++ +E
Sbjct: 1852 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1902
Score = 87.0 bits (214), Expect = 5e-17
Identities = 76/268 (28%), Positives = 133/268 (49%), Gaps = 26/268 (9%)
Query: 288 RTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQR-------ERRR 340
R E +A +E A ++ A + E + L +D ++RR+ E+ E+
Sbjct: 2016 RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 2075
Query: 341 AAKEE---ELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALE 397
A K E EL R++ E+ R ++ EL QRQ L EEE RRR +Q++L
Sbjct: 2076 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ---LAAEEERRRREAEERVQKSLA 2132
Query: 398 GQLREAEQARASMQ--AEMELKEEEAARQRQR-----IKELEEMQQRLQEALQLEVKARR 450
+ A Q +A+++ ++ K EEA R R+R ++L+ Q+ Q+ LQ E KA
Sbjct: 2133 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2192
Query: 451 ---DEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQ 507
++ + QT L++E+ L QL E R E A++ + + ++E AQ R +++
Sbjct: 2193 FAVQQKEQELQQT--LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2250
Query: 508 AQQQLEEVRQNRQRADEDVEAAQRKLRQ 535
A ++L++ + + +A +AA KLR+
Sbjct: 2251 A-ERLKQSAEEQAQARAQAQAAAEKLRK 2277
Score = 86.7 bits (213), Expect = 6e-17
Identities = 75/282 (26%), Positives = 136/282 (48%), Gaps = 27/282 (9%)
Query: 286 ANRTYEMSASDTRQRQEWTAAIQMAIRLQAEG----KTSLHK--DLKQKRREQREQRERR 339
A R +++A + R+R+E +Q ++ + E K +L + LK K E R RER
Sbjct: 2106 AARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRER- 2164
Query: 340 RAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQ 399
A++E +LQ QE +++LQ A+ +A +++E+ Q + +Q++ Q
Sbjct: 2165 --AEQESARQLQLAQEAAQKRLQ-------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2215
Query: 400 LR-EAEQARASMQAEMELK---EEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESV 455
LR EAE AR + + E + E EAA+ R++++E E ++Q +E Q +A+ E +
Sbjct: 2216 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2275
Query: 456 R----IAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQ---EKEELQQEMAQQSRSLQQA 508
R R + E+ L+Q E E++ + A+Q +K +++QE+ L++
Sbjct: 2276 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2335
Query: 509 QQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRL 550
Q + + QR + A R+ Q + VQM L
Sbjct: 2336 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2377
Score = 84.3 bits (207), Expect = 3e-16
Identities = 98/385 (25%), Positives = 178/385 (46%), Gaps = 54/385 (14%)
Query: 288 RTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRR-EQREQRERRRAAKEEE 346
R + A +Q E A + +A + A + +DL Q+R ++ +E+ +A +E
Sbjct: 2401 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2460
Query: 347 LLRLQQ--LQEEKERKLQELELLQEAQRQ-AERLLQEEEERRRSQHRELQQALEG----- 398
L+ + LQ++KE ++ LQE + Q A++L +E + +R+ E Q+ LE
Sbjct: 2461 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2520
Query: 399 --QLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEV---------K 447
+LR AE +RA +AE E+A R R++ +E+ E R + A Q +V +
Sbjct: 2521 RLKLRVAEMSRAQARAE-----EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQR 2575
Query: 448 ARRDEESVRIAQT-RLLEEEEEKLKQ---LMQLKEEQERYIERAQ--QEKEELQQ----- 496
+ D ++ R+ + LE E+EKL+Q L+QLK E+ + +++ Q QE + LQQ
Sbjct: 2576 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2635
Query: 497 --EMAQQSRSLQQAQQQLEEVRQNR----QRADEDVEAAQRKLRQASTNVKHWNVQMNRL 550
+ Q+ R ++Q + +LE++ Q+ Q+ E+ + Q+++ Q + + R
Sbjct: 2636 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRR 2695
Query: 551 MHPIEPGDKRPVTS----SSFSGFQPPLLAHRDSSLKRLTRWGSQGNRTPSPNSNEQQKS 606
H E G +R Q LLA + L+ + + +R +S E S
Sbjct: 2696 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2755
Query: 607 L--------NGGDEAPAPASTPQED 623
NG D PA+ + +
Sbjct: 2756 QVAATKTLPNGRDALDGPAAEAEPE 2780
Score = 82.8 bits (203), Expect = 9e-16
Identities = 80/306 (26%), Positives = 140/306 (45%), Gaps = 37/306 (12%)
Query: 291 EMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRL 350
E A+ +R++ E ++ + QA+ + +K R++ EQ RRA E+ LR
Sbjct: 2238 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQA-AAEKLRKEAEQEAARRAQAEQAALRQ 2296
Query: 351 QQLQE---EKERKLQELELLQEAQRQAE----RLLQEEEERRRSQHRELQQALEGQLREA 403
+Q + EK +K E L Q+AQ + E RL EE + +++ E Q L+ + EA
Sbjct: 2297 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2356
Query: 404 EQARASMQAEM---ELKEEEAARQRQRIK--------------------ELEEMQQRLQE 440
+ R+ ++ E+ ++ EE ++ + RI+ E E+M+Q +E
Sbjct: 2357 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2416
Query: 441 ALQLEVKARRDEESVRIAQTRLLEEE---EEKLKQLMQLKEEQERY---IERAQQEKEEL 494
A +L V A+ ++A+ L ++ E+ LK+ MQ +E R E QQ+KE
Sbjct: 2417 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA 2476
Query: 495 QQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRLMHPI 554
Q++ + +Q QQL E Q QR E Q ++ + +K +M+R
Sbjct: 2477 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2536
Query: 555 EPGDKR 560
E +R
Sbjct: 2537 EEDAQR 2542
Score = 81.6 bits (200), Expect = 2e-15
Identities = 75/298 (25%), Positives = 139/298 (46%), Gaps = 38/298 (12%)
Query: 288 RTYEMSASDTRQR-QEWTAAIQMAIRL---QAEGKTSLHKDLKQKRREQREQRERRRAAK 343
R E ++ R+R E AA++ +L A+ K ++ K+ ++ +E+ RR
Sbjct: 1486 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR---- 1541
Query: 344 EEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREA 403
EE + QQ + + +LQ+L EA+ QA+ E ER R + E + + QL
Sbjct: 1542 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1601
Query: 404 EQARASMQAEMEL----KEEEAARQRQRIKELEEMQQRLQEALQ--------------LE 445
E+ R + E++ EE A++RQ +E E +++++Q+ Q E
Sbjct: 1602 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1661
Query: 446 VKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYI----ERAQQEKE-ELQ----- 495
+A R+++ A L + EE ++L Q + E+ R + E AQ+ E ELQ
Sbjct: 1662 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1721
Query: 496 --QEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRLM 551
++ AQ RSLQ+ + ++R+ +R + A+R +A ++ W ++ N +
Sbjct: 1722 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1779
Score = 80.1 bits (196), Expect = 6e-15
Identities = 65/220 (29%), Positives = 109/220 (49%), Gaps = 23/220 (10%)
Query: 337 ERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQAL 396
E R +EEE L QQ EE+ER L E+E E QRQ + + + + +ELQQ +
Sbjct: 1476 ETLRRMEEEERLAEQQRAEERER-LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1534
Query: 397 EGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVR 456
+ ++ E+A Q + +EE + RQ + E+Q + ++A E R EE +R
Sbjct: 1535 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA--EIQAKARQAEAAERSRLRIEEEIR 1592
Query: 457 IAQTRLLEEEEEK------LKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQ 510
+ + +L E ++ L+ L EE E +AQ+E E L++++ +S+ +QA+
Sbjct: 1593 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1652
Query: 511 QLE-------EVRQNRQRADE-------DVEAAQRKLRQA 536
+L E + +QRA + E A+R+LRQA
Sbjct: 1653 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQA 1692
Score = 78.2 bits (191), Expect = 2e-14
Identities = 84/330 (25%), Positives = 153/330 (46%), Gaps = 58/330 (17%)
Query: 275 DGKRCMFCVKTANRTYEMSASDT-RQRQEWTAAIQMAIRLQAEGK-TSLHKDLKQKRREQ 332
+ R + A R +++ D RQR E A +A +L A G+ T L + + +E+
Sbjct: 1939 EAARLRALAEEAKRQRQLAEEDAARQRAE--AERVLAEKLAAIGEATRLKTEAEIALKEK 1996
Query: 333 REQRERRRAAKEEELLRLQQLQEEK-------ERKLQELELLQEAQRQAERLLQEEEERR 385
+ ER R E+E + ++L+E+ E +L +L +++ + ++ L E+ R+
Sbjct: 1997 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 2056
Query: 386 RSQHRELQQALEGQLREAEQARASMQAEM--------------ELKEEEAARQRQRIKEL 431
R Q E AL+ +A +A ++ E+ E E EAARQRQ E
Sbjct: 2057 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 2116
Query: 432 E----EMQQRLQEALQLEVKARRDEESV---------RIAQTRLLEE--EEEKLKQLM-- 474
E E ++R+Q++L E +A R ++ ++ + R L E E+E +QL
Sbjct: 2117 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2176
Query: 475 ------QLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVR---QNRQRADED 525
+L+ E++ + QQ+++ELQQ +LQQ Q L+++R + +RA E+
Sbjct: 2177 QEAAQKRLQAEEKAHAFAVQQKEQELQQ-------TLQQEQSVLDQLRGEAEAARRAAEE 2229
Query: 526 VEAAQRKLRQASTNVKHWNVQMNRLMHPIE 555
E A+ + + + + + RL E
Sbjct: 2230 AEEARVQAEREAAQSRRQVEEAERLKQSAE 2259
Score = 78.2 bits (191), Expect = 2e-14
Identities = 72/254 (28%), Positives = 127/254 (50%), Gaps = 27/254 (10%)
Query: 291 EMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRL 350
E+ R E T + L+A + L + +++RR + E+R ++ A EEE R
Sbjct: 2082 ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE-EERRRREAEERVQKSLAAEEEAAR- 2139
Query: 351 QQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASM 410
+++ L+E+E L+ +A RL + E+ Q + Q+A + +L+ E+A A
Sbjct: 2140 -----QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2194
Query: 411 QAEMELKEEEAARQRQRIK-----ELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEE 465
+ E + ++ +Q Q + E E ++ +EA + V+A R+ AQ+R E
Sbjct: 2195 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA-----AQSRRQVE 2249
Query: 466 EEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADED 525
E E+LKQ EEQ + +AQ E+L++E Q++ QA+Q +RQ +Q AD +
Sbjct: 2250 EAERLKQSA---EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA--LRQ-KQAADAE 2303
Query: 526 VEA----AQRKLRQ 535
+E A++ LRQ
Sbjct: 2304 MEKHKKFAEQTLRQ 2317
Score = 76.6 bits (187), Expect = 6e-14
Identities = 77/302 (25%), Positives = 146/302 (48%), Gaps = 37/302 (12%)
Query: 251 EECKEKRGIIPLDAHCCVEVLPDRDGKRCMFCVKTANRTYEMSASDTRQRQ-EWTAAIQM 309
E ++++ + L + E R+ +R + ++ E + RQ + E +Q+
Sbjct: 1643 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1702
Query: 310 AIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQE 369
A+ + S +L+ KR E+ + + +EE + + QL+EE ER+ Q+ +
Sbjct: 1703 ALET---AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1759
Query: 370 AQRQAERLLQE------EEERRRSQHRELQQALEGQLREAEQARASMQAEMELK-----E 418
A+ +AER L+ E R R Q E+ Q + L +AE + +AE E + E
Sbjct: 1760 AREEAERELERWQLKANEALRLRLQAEEVAQ--QKSLAQAEAEKQKEEAEREARRRGKAE 1817
Query: 419 EEAARQRQRIK-ELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLK 477
E+A RQR+ + ELE+ +Q + Q + A ++E +R L E E+ +Q QL
Sbjct: 1818 EQAVRQRELAEQELEKQRQLAEGTAQQRLAA--EQELIR------LRAETEQGEQQRQLL 1869
Query: 478 EEQERYIER----AQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKL 533
EE+ ++R A Q+++EL+ E+A + + ++E + ++ RA+E+ + K
Sbjct: 1870 EEELARLQREAAAATQKRQELEAELA-------KVRAEMEVLLASKARAEEESRSTSEKS 1922
Query: 534 RQ 535
+Q
Sbjct: 1923 KQ 1924
Score = 74.3 bits (181), Expect = 3e-13
Identities = 81/293 (27%), Positives = 141/293 (48%), Gaps = 38/293 (12%)
Query: 284 KTANRTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQ---KRREQREQRERRR 340
+ A R + RQR+ ++ +L AEG +Q + R + EQ E++R
Sbjct: 1808 REARRRGKAEEQAVRQRELAEQELEKQRQL-AEGTAQQRLAAEQELIRLRAETEQGEQQR 1866
Query: 341 AAKEEELLRLQQLQEEKERKLQELEL-LQEAQRQAERLLQEE---EERRRSQHRELQQAL 396
EEEL RLQ+ +K QELE L + + + E LL + EE RS + +Q L
Sbjct: 1867 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1926
Query: 397 E---GQLRE-----------AEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEAL 442
E G+ RE AE+A+ Q L EE+AARQR E ++ L E L
Sbjct: 1927 EAEAGRFRELAEEAARLRALAEEAKRQRQ----LAEEDAARQR------AEAERVLAEKL 1976
Query: 443 QLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYI-ERAQQEKEELQQEMAQQ 501
+A R + IA + E E E+L++L + + Q R + E+A Q K ++++ +AQ
Sbjct: 1977 AAIGEATRLKTEAEIA-LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 2035
Query: 502 SRS----LQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRL 550
++ L++ + +E+ + R++ +E++ A + +A+ +++ R+
Sbjct: 2036 RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 2088
Score = 62.8 bits (151), Expect = 9e-10
Identities = 76/303 (25%), Positives = 138/303 (45%), Gaps = 61/303 (20%)
Query: 296 DTRQRQEWTAAIQMA----IRLQAEGKTSLHKDLKQKRRE----QREQRERRRAAKEEEL 347
D R+RQE A+ +A +R Q + +L +++++ + QR ++ A K+ EL
Sbjct: 1362 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYEL 1421
Query: 348 ---------------LRLQQLQEEKERKLQELELLQEAQRQ------------AERLLQE 380
+ ++Q E +QE L+ + +E L +
Sbjct: 1422 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1481
Query: 381 EEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQE 440
EEE R ++ QQ E + R AE A+++ + +L E A + Q +E +E+QQR+QE
Sbjct: 1482 EEEERLAE----QQRAEERERLAE-VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE 1536
Query: 441 ALQLEVKARRDEESVRI-AQTRLLEEEEEKLKQL----MQLKEEQERYIERAQQEKEE-- 493
+ RR+E +V Q R ++EE ++L+Q +Q K Q ER++ EE
Sbjct: 1537 EV-----VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1591
Query: 494 ----LQQEMAQQSR-----SLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWN 544
LQ E ++ R LQ + + EE +++A E+ E +R+++ S +
Sbjct: 1592 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1651
Query: 545 VQM 547
V++
Sbjct: 1652 VEL 1654
Score = 45.1 bits (105), Expect = 2e-04
Identities = 45/154 (29%), Positives = 72/154 (46%), Gaps = 12/154 (7%)
Query: 336 RERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQA 395
R AK+E L + E KE+K++EL Q +RLL+E+ R + Q A
Sbjct: 784 RNTNMTAKKESYSALMRELELKEKKIKEL------QNAGDRLLREDHPARPTV-ESFQAA 836
Query: 396 LEGQLREAEQARASMQAEMELKEEEAARQ-RQRIKELEEMQQRLQEALQLEVKARRDEES 454
L+ Q Q ++A LKE A Q ++E E Q+LQEAL+ + R
Sbjct: 837 LQTQWSWMLQLCCCIEA--HLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 894
Query: 455 VRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQ 488
R+ LL++ +++ +QL + K +RA+
Sbjct: 895 TRLED--LLQDAQDEKEQLNEYKGHLSGLAKRAK 926
Score = 38.9 bits (89), Expect = 0.015
Identities = 68/281 (24%), Positives = 125/281 (44%), Gaps = 44/281 (15%)
Query: 274 RDGKRCMFCV-KTANRTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQ 332
++ RC C+ + + ++ A +TR ++ + L E + + ++++ Q
Sbjct: 1114 QEESRCQRCISELKDIRLQLEACETR------TVHRLRLPLDKEPARECAQRIAEQQKAQ 1167
Query: 333 RE-----QRERRRAAKEEELLRLQQ-------LQEEKERKLQELELLQEAQR-QAERLLQ 379
E + R +A+ E++L L + L+ E E L +LE ++ E+L
Sbjct: 1168 AEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKT 1227
Query: 380 EEEERRRSQH-RELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRL 438
R +Q E+ +A E QL+EA+ A++ EL+ +A+ ++ R +
Sbjct: 1228 ISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP---ELEATKASLKKLRAQA-------- 1276
Query: 439 QEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKE-EQERYIERAQQEKEELQQE 497
EA Q A RDE R +E E+L+Q ++ E ER+ ER Q E Q
Sbjct: 1277 -EAQQPTFDALRDE-------LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAV 1328
Query: 498 MAQ---QSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQ 535
+AQ + R L+Q +QL R++ ++ A+R+ Q
Sbjct: 1329 LAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1369
Score = 38.5 bits (88), Expect = 0.019
Identities = 59/265 (22%), Positives = 117/265 (44%), Gaps = 36/265 (13%)
Query: 312 RLQAE---GKTSLHKDLKQKRREQREQRERR--RAAKEEELLRLQQLQEEKERKLQELEL 366
RL AE G S H + EQ Q E R R E + +RLQ L+ + R + L L
Sbjct: 1088 RLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQ-LEACETRTVHRLRL 1146
Query: 367 ---LQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARA---------SMQAEM 414
+ A+ A+R+ E+++ +++ L + + EAE+ A ++++E+
Sbjct: 1147 PLDKEPARECAQRIA--EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL 1204
Query: 415 ELK----EEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQT-----RLLEE 465
EL E+ + +++L+ + ++ E R EE ++ AQ LE
Sbjct: 1205 ELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1264
Query: 466 EEEKLKQLMQLKEEQERYIER-------AQQEKEELQQEMAQQSRSLQQAQQQLEEVRQN 518
+ LK+L E Q+ + AQ+ E LQQ ++ +++ ++++ ++ +
Sbjct: 1265 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1324
Query: 519 RQRADEDVEAAQRKLRQASTNVKHW 543
Q + QR+L Q ++++
Sbjct: 1325 WQAVLAQTDVRQRELEQLGRQLRYY 1349
Score = 37.4 bits (85), Expect = 0.042
Identities = 45/184 (24%), Positives = 80/184 (43%), Gaps = 17/184 (9%)
Query: 342 AKEEELLRLQQLQ------EEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQA 395
A EE+L Q + E + L++L EAQ+ L++E + LQQ
Sbjct: 1244 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1303
Query: 396 LEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLE-------VKA 448
+ E E+ R + +E + A+ R +ELE++ ++L+ + A
Sbjct: 1304 HGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA 1363
Query: 449 RRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQA 508
RR +E ++ + E+L+Q L EE ER+ E+ EE Q+ Q +++
Sbjct: 1364 RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKV----EECQRFAKQYINAIKDY 1419
Query: 509 QQQL 512
+ QL
Sbjct: 1420 ELQL 1423
Score = 31.2 bits (69), Expect = 3.0
Identities = 47/203 (23%), Positives = 84/203 (41%), Gaps = 20/203 (9%)
Query: 339 RRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEG 398
R E RL+ LQ + E L +E QA+ LLQ + R + + Q+A E
Sbjct: 517 REKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQ-SDVRLLAAGKVPQRAGEV 575
Query: 399 QLREAEQARA-------SMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRD 451
+ R+ ++A + +Q + + + + +R+ L E ++ L +KA
Sbjct: 576 E-RDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVA 634
Query: 452 EESVRIAQTRLL------EEEEEKLKQLMQL---KEEQERYIERAQQEKEELQQEMAQQS 502
+ ++AQ L E E+ L+ L L EE + ++ A+ + + Q
Sbjct: 635 APATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVD--LPSVEAQL 692
Query: 503 RSLQQAQQQLEEVRQNRQRADED 525
S + Q +EE R +RA D
Sbjct: 693 GSHRGLHQSIEEFRAKIERARSD 715
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 92.4 bits (228), Expect = 1e-18
Identities = 77/291 (26%), Positives = 144/291 (49%), Gaps = 34/291 (11%)
Query: 291 EMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQ-RERRRAAKEEELLR 349
E + + RQ QE ++ ++ +++ K +L + + + E RE++RA + E LR
Sbjct: 1461 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1520
Query: 350 LQQLQEEKERKLQELEL---------LQEAQRQAERLLQEEEERRRSQHRELQQALE--- 397
LQ EE ER+L++ E+ L+ AQR AE LQ + + +L+++L+
Sbjct: 1521 LQA--EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEH 1578
Query: 398 ---GQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEES 454
QLRE + RA QAE E EEA R ELE Q + EAL+L ++A +
Sbjct: 1579 VAVAQLREEAERRAQQQAEAERAREEAER------ELERWQLKANEALRLRLQAEEVAQQ 1632
Query: 455 VRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQ---AQQQ 511
+AQ +++EE ++ + + +E+ + + + ++EL+++ + QQ A+Q+
Sbjct: 1633 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1692
Query: 512 L-------EEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRLMHPIE 555
L E+ Q RQ +E++ QR+ A+ + ++ ++ +E
Sbjct: 1693 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1743
Score = 87.0 bits (214), Expect = 5e-17
Identities = 76/268 (28%), Positives = 133/268 (49%), Gaps = 26/268 (9%)
Query: 288 RTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQR-------ERRR 340
R E +A +E A ++ A + E + L +D ++RR+ E+ E+
Sbjct: 1857 RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1916
Query: 341 AAKEE---ELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALE 397
A K E EL R++ E+ R ++ EL QRQ L EEE RRR +Q++L
Sbjct: 1917 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ---LAAEEERRRREAEERVQKSLA 1973
Query: 398 GQLREAEQARASMQ--AEMELKEEEAARQRQR-----IKELEEMQQRLQEALQLEVKARR 450
+ A Q +A+++ ++ K EEA R R+R ++L+ Q+ Q+ LQ E KA
Sbjct: 1974 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2033
Query: 451 ---DEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQ 507
++ + QT L++E+ L QL E R E A++ + + ++E AQ R +++
Sbjct: 2034 FAVQQKEQELQQT--LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2091
Query: 508 AQQQLEEVRQNRQRADEDVEAAQRKLRQ 535
A ++L++ + + +A +AA KLR+
Sbjct: 2092 A-ERLKQSAEEQAQARAQAQAAAEKLRK 2118
Score = 86.7 bits (213), Expect = 6e-17
Identities = 75/282 (26%), Positives = 136/282 (48%), Gaps = 27/282 (9%)
Query: 286 ANRTYEMSASDTRQRQEWTAAIQMAIRLQAEG----KTSLHK--DLKQKRREQREQRERR 339
A R +++A + R+R+E +Q ++ + E K +L + LK K E R RER
Sbjct: 1947 AARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRER- 2005
Query: 340 RAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQ 399
A++E +LQ QE +++LQ A+ +A +++E+ Q + +Q++ Q
Sbjct: 2006 --AEQESARQLQLAQEAAQKRLQ-------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2056
Query: 400 LR-EAEQARASMQAEMELK---EEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESV 455
LR EAE AR + + E + E EAA+ R++++E E ++Q +E Q +A+ E +
Sbjct: 2057 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2116
Query: 456 R----IAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQ---EKEELQQEMAQQSRSLQQA 508
R R + E+ L+Q E E++ + A+Q +K +++QE+ L++
Sbjct: 2117 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2176
Query: 509 QQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRL 550
Q + + QR + A R+ Q + VQM L
Sbjct: 2177 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2218
Score = 84.3 bits (207), Expect = 3e-16
Identities = 98/385 (25%), Positives = 178/385 (46%), Gaps = 54/385 (14%)
Query: 288 RTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRR-EQREQRERRRAAKEEE 346
R + A +Q E A + +A + A + +DL Q+R ++ +E+ +A +E
Sbjct: 2242 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2301
Query: 347 LLRLQQ--LQEEKERKLQELELLQEAQRQ-AERLLQEEEERRRSQHRELQQALEG----- 398
L+ + LQ++KE ++ LQE + Q A++L +E + +R+ E Q+ LE
Sbjct: 2302 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2361
Query: 399 --QLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEV---------K 447
+LR AE +RA +AE E+A R R++ +E+ E R + A Q +V +
Sbjct: 2362 RLKLRVAEMSRAQARAE-----EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQR 2416
Query: 448 ARRDEESVRIAQT-RLLEEEEEKLKQ---LMQLKEEQERYIERAQ--QEKEELQQ----- 496
+ D ++ R+ + LE E+EKL+Q L+QLK E+ + +++ Q QE + LQQ
Sbjct: 2417 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2476
Query: 497 --EMAQQSRSLQQAQQQLEEVRQNR----QRADEDVEAAQRKLRQASTNVKHWNVQMNRL 550
+ Q+ R ++Q + +LE++ Q+ Q+ E+ + Q+++ Q + + R
Sbjct: 2477 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRR 2536
Query: 551 MHPIEPGDKRPVTS----SSFSGFQPPLLAHRDSSLKRLTRWGSQGNRTPSPNSNEQQKS 606
H E G +R Q LLA + L+ + + +R +S E S
Sbjct: 2537 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2596
Query: 607 L--------NGGDEAPAPASTPQED 623
NG D PA+ + +
Sbjct: 2597 QVAATKTLPNGRDALDGPAAEAEPE 2621
Score = 82.8 bits (203), Expect = 9e-16
Identities = 80/306 (26%), Positives = 140/306 (45%), Gaps = 37/306 (12%)
Query: 291 EMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRL 350
E A+ +R++ E ++ + QA+ + +K R++ EQ RRA E+ LR
Sbjct: 2079 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQA-AAEKLRKEAEQEAARRAQAEQAALRQ 2137
Query: 351 QQLQE---EKERKLQELELLQEAQRQAE----RLLQEEEERRRSQHRELQQALEGQLREA 403
+Q + EK +K E L Q+AQ + E RL EE + +++ E Q L+ + EA
Sbjct: 2138 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2197
Query: 404 EQARASMQAEM---ELKEEEAARQRQRIK--------------------ELEEMQQRLQE 440
+ R+ ++ E+ ++ EE ++ + RI+ E E+M+Q +E
Sbjct: 2198 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2257
Query: 441 ALQLEVKARRDEESVRIAQTRLLEEE---EEKLKQLMQLKEEQERY---IERAQQEKEEL 494
A +L V A+ ++A+ L ++ E+ LK+ MQ +E R E QQ+KE
Sbjct: 2258 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA 2317
Query: 495 QQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRLMHPI 554
Q++ + +Q QQL E Q QR E Q ++ + +K +M+R
Sbjct: 2318 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2377
Query: 555 EPGDKR 560
E +R
Sbjct: 2378 EEDAQR 2383
Score = 81.6 bits (200), Expect = 2e-15
Identities = 75/298 (25%), Positives = 139/298 (46%), Gaps = 38/298 (12%)
Query: 288 RTYEMSASDTRQR-QEWTAAIQMAIRL---QAEGKTSLHKDLKQKRREQREQRERRRAAK 343
R E ++ R+R E AA++ +L A+ K ++ K+ ++ +E+ RR
Sbjct: 1327 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR---- 1382
Query: 344 EEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREA 403
EE + QQ + + +LQ+L EA+ QA+ E ER R + E + + QL
Sbjct: 1383 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1442
Query: 404 EQARASMQAEMEL----KEEEAARQRQRIKELEEMQQRLQEALQ--------------LE 445
E+ R + E++ EE A++RQ +E E +++++Q+ Q E
Sbjct: 1443 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1502
Query: 446 VKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYI----ERAQQEKE-ELQ----- 495
+A R+++ A L + EE ++L Q + E+ R + E AQ+ E ELQ
Sbjct: 1503 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1562
Query: 496 --QEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRLM 551
++ AQ RSLQ+ + ++R+ +R + A+R +A ++ W ++ N +
Sbjct: 1563 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1620
Score = 80.1 bits (196), Expect = 6e-15
Identities = 65/220 (29%), Positives = 109/220 (49%), Gaps = 23/220 (10%)
Query: 337 ERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQAL 396
E R +EEE L QQ EE+ER L E+E E QRQ + + + + +ELQQ +
Sbjct: 1317 ETLRRMEEEERLAEQQRAEERER-LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1375
Query: 397 EGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVR 456
+ ++ E+A Q + +EE + RQ + E+Q + ++A E R EE +R
Sbjct: 1376 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA--EIQAKARQAEAAERSRLRIEEEIR 1433
Query: 457 IAQTRLLEEEEEK------LKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQ 510
+ + +L E ++ L+ L EE E +AQ+E E L++++ +S+ +QA+
Sbjct: 1434 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1493
Query: 511 QLE-------EVRQNRQRADE-------DVEAAQRKLRQA 536
+L E + +QRA + E A+R+LRQA
Sbjct: 1494 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQA 1533
Score = 78.2 bits (191), Expect = 2e-14
Identities = 84/330 (25%), Positives = 153/330 (46%), Gaps = 58/330 (17%)
Query: 275 DGKRCMFCVKTANRTYEMSASDT-RQRQEWTAAIQMAIRLQAEGK-TSLHKDLKQKRREQ 332
+ R + A R +++ D RQR E A +A +L A G+ T L + + +E+
Sbjct: 1780 EAARLRALAEEAKRQRQLAEEDAARQRAE--AERVLAEKLAAIGEATRLKTEAEIALKEK 1837
Query: 333 REQRERRRAAKEEELLRLQQLQEEK-------ERKLQELELLQEAQRQAERLLQEEEERR 385
+ ER R E+E + ++L+E+ E +L +L +++ + ++ L E+ R+
Sbjct: 1838 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 1897
Query: 386 RSQHRELQQALEGQLREAEQARASMQAEM--------------ELKEEEAARQRQRIKEL 431
R Q E AL+ +A +A ++ E+ E E EAARQRQ E
Sbjct: 1898 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1957
Query: 432 E----EMQQRLQEALQLEVKARRDEESV---------RIAQTRLLEE--EEEKLKQLM-- 474
E E ++R+Q++L E +A R ++ ++ + R L E E+E +QL
Sbjct: 1958 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2017
Query: 475 ------QLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVR---QNRQRADED 525
+L+ E++ + QQ+++ELQQ +LQQ Q L+++R + +RA E+
Sbjct: 2018 QEAAQKRLQAEEKAHAFAVQQKEQELQQ-------TLQQEQSVLDQLRGEAEAARRAAEE 2070
Query: 526 VEAAQRKLRQASTNVKHWNVQMNRLMHPIE 555
E A+ + + + + + RL E
Sbjct: 2071 AEEARVQAEREAAQSRRQVEEAERLKQSAE 2100
Score = 78.2 bits (191), Expect = 2e-14
Identities = 72/254 (28%), Positives = 127/254 (50%), Gaps = 27/254 (10%)
Query: 291 EMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRL 350
E+ R E T + L+A + L + +++RR + E+R ++ A EEE R
Sbjct: 1923 ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE-EERRRREAEERVQKSLAAEEEAAR- 1980
Query: 351 QQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASM 410
+++ L+E+E L+ +A RL + E+ Q + Q+A + +L+ E+A A
Sbjct: 1981 -----QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2035
Query: 411 QAEMELKEEEAARQRQRIK-----ELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEE 465
+ E + ++ +Q Q + E E ++ +EA + V+A R+ AQ+R E
Sbjct: 2036 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA-----AQSRRQVE 2090
Query: 466 EEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADED 525
E E+LKQ EEQ + +AQ E+L++E Q++ QA+Q +RQ +Q AD +
Sbjct: 2091 EAERLKQSA---EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA--LRQ-KQAADAE 2144
Query: 526 VEA----AQRKLRQ 535
+E A++ LRQ
Sbjct: 2145 MEKHKKFAEQTLRQ 2158
Score = 76.6 bits (187), Expect = 6e-14
Identities = 77/302 (25%), Positives = 146/302 (48%), Gaps = 37/302 (12%)
Query: 251 EECKEKRGIIPLDAHCCVEVLPDRDGKRCMFCVKTANRTYEMSASDTRQRQ-EWTAAIQM 309
E ++++ + L + E R+ +R + ++ E + RQ + E +Q+
Sbjct: 1484 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1543
Query: 310 AIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQE 369
A+ + S +L+ KR E+ + + +EE + + QL+EE ER+ Q+ +
Sbjct: 1544 ALET---AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1600
Query: 370 AQRQAERLLQE------EEERRRSQHRELQQALEGQLREAEQARASMQAEMELK-----E 418
A+ +AER L+ E R R Q E+ Q + L +AE + +AE E + E
Sbjct: 1601 AREEAERELERWQLKANEALRLRLQAEEVAQ--QKSLAQAEAEKQKEEAEREARRRGKAE 1658
Query: 419 EEAARQRQRIK-ELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLK 477
E+A RQR+ + ELE+ +Q + Q + A ++E +R L E E+ +Q QL
Sbjct: 1659 EQAVRQRELAEQELEKQRQLAEGTAQQRLAA--EQELIR------LRAETEQGEQQRQLL 1710
Query: 478 EEQERYIER----AQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKL 533
EE+ ++R A Q+++EL+ E+A + + ++E + ++ RA+E+ + K
Sbjct: 1711 EEELARLQREAAAATQKRQELEAELA-------KVRAEMEVLLASKARAEEESRSTSEKS 1763
Query: 534 RQ 535
+Q
Sbjct: 1764 KQ 1765
Score = 74.3 bits (181), Expect = 3e-13
Identities = 81/293 (27%), Positives = 141/293 (48%), Gaps = 38/293 (12%)
Query: 284 KTANRTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQ---KRREQREQRERRR 340
+ A R + RQR+ ++ +L AEG +Q + R + EQ E++R
Sbjct: 1649 REARRRGKAEEQAVRQRELAEQELEKQRQL-AEGTAQQRLAAEQELIRLRAETEQGEQQR 1707
Query: 341 AAKEEELLRLQQLQEEKERKLQELEL-LQEAQRQAERLLQEE---EERRRSQHRELQQAL 396
EEEL RLQ+ +K QELE L + + + E LL + EE RS + +Q L
Sbjct: 1708 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1767
Query: 397 E---GQLRE-----------AEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEAL 442
E G+ RE AE+A+ Q L EE+AARQR E ++ L E L
Sbjct: 1768 EAEAGRFRELAEEAARLRALAEEAKRQRQ----LAEEDAARQR------AEAERVLAEKL 1817
Query: 443 QLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYI-ERAQQEKEELQQEMAQQ 501
+A R + IA + E E E+L++L + + Q R + E+A Q K ++++ +AQ
Sbjct: 1818 AAIGEATRLKTEAEIA-LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1876
Query: 502 SRS----LQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRL 550
++ L++ + +E+ + R++ +E++ A + +A+ +++ R+
Sbjct: 1877 RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1929
Score = 62.8 bits (151), Expect = 9e-10
Identities = 76/303 (25%), Positives = 138/303 (45%), Gaps = 61/303 (20%)
Query: 296 DTRQRQEWTAAIQMA----IRLQAEGKTSLHKDLKQKRRE----QREQRERRRAAKEEEL 347
D R+RQE A+ +A +R Q + +L +++++ + QR ++ A K+ EL
Sbjct: 1203 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYEL 1262
Query: 348 ---------------LRLQQLQEEKERKLQELELLQEAQRQ------------AERLLQE 380
+ ++Q E +QE L+ + +E L +
Sbjct: 1263 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1322
Query: 381 EEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQE 440
EEE R ++ QQ E + R AE A+++ + +L E A + Q +E +E+QQR+QE
Sbjct: 1323 EEEERLAE----QQRAEERERLAE-VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE 1377
Query: 441 ALQLEVKARRDEESVRI-AQTRLLEEEEEKLKQL----MQLKEEQERYIERAQQEKEE-- 493
+ RR+E +V Q R ++EE ++L+Q +Q K Q ER++ EE
Sbjct: 1378 EV-----VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1432
Query: 494 ----LQQEMAQQSR-----SLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWN 544
LQ E ++ R LQ + + EE +++A E+ E +R+++ S +
Sbjct: 1433 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1492
Query: 545 VQM 547
V++
Sbjct: 1493 VEL 1495
Score = 45.1 bits (105), Expect = 2e-04
Identities = 45/154 (29%), Positives = 72/154 (46%), Gaps = 12/154 (7%)
Query: 336 RERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQA 395
R AK+E L + E KE+K++EL Q +RLL+E+ R + Q A
Sbjct: 625 RNTNMTAKKESYSALMRELELKEKKIKEL------QNAGDRLLREDHPARPTV-ESFQAA 677
Query: 396 LEGQLREAEQARASMQAEMELKEEEAARQ-RQRIKELEEMQQRLQEALQLEVKARRDEES 454
L+ Q Q ++A LKE A Q ++E E Q+LQEAL+ + R
Sbjct: 678 LQTQWSWMLQLCCCIEA--HLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 735
Query: 455 VRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQ 488
R+ LL++ +++ +QL + K +RA+
Sbjct: 736 TRLED--LLQDAQDEKEQLNEYKGHLSGLAKRAK 767
Score = 38.9 bits (89), Expect = 0.015
Identities = 68/281 (24%), Positives = 125/281 (44%), Gaps = 44/281 (15%)
Query: 274 RDGKRCMFCV-KTANRTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQ 332
++ RC C+ + + ++ A +TR ++ + L E + + ++++ Q
Sbjct: 955 QEESRCQRCISELKDIRLQLEACETR------TVHRLRLPLDKEPARECAQRIAEQQKAQ 1008
Query: 333 RE-----QRERRRAAKEEELLRLQQ-------LQEEKERKLQELELLQEAQR-QAERLLQ 379
E + R +A+ E++L L + L+ E E L +LE ++ E+L
Sbjct: 1009 AEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKT 1068
Query: 380 EEEERRRSQH-RELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRL 438
R +Q E+ +A E QL+EA+ A++ EL+ +A+ ++ R +
Sbjct: 1069 ISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP---ELEATKASLKKLRAQA-------- 1117
Query: 439 QEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKE-EQERYIERAQQEKEELQQE 497
EA Q A RDE R +E E+L+Q ++ E ER+ ER Q E Q
Sbjct: 1118 -EAQQPTFDALRDE-------LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAV 1169
Query: 498 MAQ---QSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQ 535
+AQ + R L+Q +QL R++ ++ A+R+ Q
Sbjct: 1170 LAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1210
Score = 38.5 bits (88), Expect = 0.019
Identities = 59/265 (22%), Positives = 117/265 (44%), Gaps = 36/265 (13%)
Query: 312 RLQAE---GKTSLHKDLKQKRREQREQRERR--RAAKEEELLRLQQLQEEKERKLQELEL 366
RL AE G S H + EQ Q E R R E + +RLQ L+ + R + L L
Sbjct: 929 RLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQ-LEACETRTVHRLRL 987
Query: 367 ---LQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARA---------SMQAEM 414
+ A+ A+R+ E+++ +++ L + + EAE+ A ++++E+
Sbjct: 988 PLDKEPARECAQRIA--EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL 1045
Query: 415 ELK----EEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQT-----RLLEE 465
EL E+ + +++L+ + ++ E R EE ++ AQ LE
Sbjct: 1046 ELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1105
Query: 466 EEEKLKQLMQLKEEQERYIER-------AQQEKEELQQEMAQQSRSLQQAQQQLEEVRQN 518
+ LK+L E Q+ + AQ+ E LQQ ++ +++ ++++ ++ +
Sbjct: 1106 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1165
Query: 519 RQRADEDVEAAQRKLRQASTNVKHW 543
Q + QR+L Q ++++
Sbjct: 1166 WQAVLAQTDVRQRELEQLGRQLRYY 1190
Score = 37.4 bits (85), Expect = 0.042
Identities = 45/184 (24%), Positives = 80/184 (43%), Gaps = 17/184 (9%)
Query: 342 AKEEELLRLQQLQ------EEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQA 395
A EE+L Q + E + L++L EAQ+ L++E + LQQ
Sbjct: 1085 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1144
Query: 396 LEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLE-------VKA 448
+ E E+ R + +E + A+ R +ELE++ ++L+ + A
Sbjct: 1145 HGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA 1204
Query: 449 RRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQA 508
RR +E ++ + E+L+Q L EE ER+ E+ EE Q+ Q +++
Sbjct: 1205 RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKV----EECQRFAKQYINAIKDY 1260
Query: 509 QQQL 512
+ QL
Sbjct: 1261 ELQL 1264
Score = 31.2 bits (69), Expect = 3.0
Identities = 47/203 (23%), Positives = 84/203 (41%), Gaps = 20/203 (9%)
Query: 339 RRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEG 398
R E RL+ LQ + E L +E QA+ LLQ + R + + Q+A E
Sbjct: 358 REKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQ-SDVRLLAAGKVPQRAGEV 416
Query: 399 QLREAEQARA-------SMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRD 451
+ R+ ++A + +Q + + + + +R+ L E ++ L +KA
Sbjct: 417 E-RDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVA 475
Query: 452 EESVRIAQTRLL------EEEEEKLKQLMQL---KEEQERYIERAQQEKEELQQEMAQQS 502
+ ++AQ L E E+ L+ L L EE + ++ A+ + + Q
Sbjct: 476 APATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVD--LPSVEAQL 533
Query: 503 RSLQQAQQQLEEVRQNRQRADED 525
S + Q +EE R +RA D
Sbjct: 534 GSHRGLHQSIEEFRAKIERARSD 556
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 92.4 bits (228), Expect = 1e-18
Identities = 77/291 (26%), Positives = 144/291 (49%), Gaps = 34/291 (11%)
Query: 291 EMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQ-RERRRAAKEEELLR 349
E + + RQ QE ++ ++ +++ K +L + + + E RE++RA + E LR
Sbjct: 1469 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1528
Query: 350 LQQLQEEKERKLQELEL---------LQEAQRQAERLLQEEEERRRSQHRELQQALE--- 397
LQ EE ER+L++ E+ L+ AQR AE LQ + + +L+++L+
Sbjct: 1529 LQA--EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEH 1586
Query: 398 ---GQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEES 454
QLRE + RA QAE E EEA R ELE Q + EAL+L ++A +
Sbjct: 1587 VAVAQLREEAERRAQQQAEAERAREEAER------ELERWQLKANEALRLRLQAEEVAQQ 1640
Query: 455 VRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQ---AQQQ 511
+AQ +++EE ++ + + +E+ + + + ++EL+++ + QQ A+Q+
Sbjct: 1641 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1700
Query: 512 L-------EEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRLMHPIE 555
L E+ Q RQ +E++ QR+ A+ + ++ ++ +E
Sbjct: 1701 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1751
Score = 87.0 bits (214), Expect = 5e-17
Identities = 76/268 (28%), Positives = 133/268 (49%), Gaps = 26/268 (9%)
Query: 288 RTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQR-------ERRR 340
R E +A +E A ++ A + E + L +D ++RR+ E+ E+
Sbjct: 1865 RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1924
Query: 341 AAKEE---ELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALE 397
A K E EL R++ E+ R ++ EL QRQ L EEE RRR +Q++L
Sbjct: 1925 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ---LAAEEERRRREAEERVQKSLA 1981
Query: 398 GQLREAEQARASMQ--AEMELKEEEAARQRQR-----IKELEEMQQRLQEALQLEVKARR 450
+ A Q +A+++ ++ K EEA R R+R ++L+ Q+ Q+ LQ E KA
Sbjct: 1982 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2041
Query: 451 ---DEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQ 507
++ + QT L++E+ L QL E R E A++ + + ++E AQ R +++
Sbjct: 2042 FAVQQKEQELQQT--LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2099
Query: 508 AQQQLEEVRQNRQRADEDVEAAQRKLRQ 535
A ++L++ + + +A +AA KLR+
Sbjct: 2100 A-ERLKQSAEEQAQARAQAQAAAEKLRK 2126
Score = 86.7 bits (213), Expect = 6e-17
Identities = 75/282 (26%), Positives = 136/282 (48%), Gaps = 27/282 (9%)
Query: 286 ANRTYEMSASDTRQRQEWTAAIQMAIRLQAEG----KTSLHK--DLKQKRREQREQRERR 339
A R +++A + R+R+E +Q ++ + E K +L + LK K E R RER
Sbjct: 1955 AARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRER- 2013
Query: 340 RAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQ 399
A++E +LQ QE +++LQ A+ +A +++E+ Q + +Q++ Q
Sbjct: 2014 --AEQESARQLQLAQEAAQKRLQ-------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2064
Query: 400 LR-EAEQARASMQAEMELK---EEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESV 455
LR EAE AR + + E + E EAA+ R++++E E ++Q +E Q +A+ E +
Sbjct: 2065 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2124
Query: 456 R----IAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQ---EKEELQQEMAQQSRSLQQA 508
R R + E+ L+Q E E++ + A+Q +K +++QE+ L++
Sbjct: 2125 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2184
Query: 509 QQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRL 550
Q + + QR + A R+ Q + VQM L
Sbjct: 2185 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2226
Score = 84.3 bits (207), Expect = 3e-16
Identities = 98/385 (25%), Positives = 178/385 (46%), Gaps = 54/385 (14%)
Query: 288 RTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRR-EQREQRERRRAAKEEE 346
R + A +Q E A + +A + A + +DL Q+R ++ +E+ +A +E
Sbjct: 2250 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2309
Query: 347 LLRLQQ--LQEEKERKLQELELLQEAQRQ-AERLLQEEEERRRSQHRELQQALEG----- 398
L+ + LQ++KE ++ LQE + Q A++L +E + +R+ E Q+ LE
Sbjct: 2310 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2369
Query: 399 --QLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEV---------K 447
+LR AE +RA +AE E+A R R++ +E+ E R + A Q +V +
Sbjct: 2370 RLKLRVAEMSRAQARAE-----EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQR 2424
Query: 448 ARRDEESVRIAQT-RLLEEEEEKLKQ---LMQLKEEQERYIERAQ--QEKEELQQ----- 496
+ D ++ R+ + LE E+EKL+Q L+QLK E+ + +++ Q QE + LQQ
Sbjct: 2425 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2484
Query: 497 --EMAQQSRSLQQAQQQLEEVRQNR----QRADEDVEAAQRKLRQASTNVKHWNVQMNRL 550
+ Q+ R ++Q + +LE++ Q+ Q+ E+ + Q+++ Q + + R
Sbjct: 2485 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRR 2544
Query: 551 MHPIEPGDKRPVTS----SSFSGFQPPLLAHRDSSLKRLTRWGSQGNRTPSPNSNEQQKS 606
H E G +R Q LLA + L+ + + +R +S E S
Sbjct: 2545 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2604
Query: 607 L--------NGGDEAPAPASTPQED 623
NG D PA+ + +
Sbjct: 2605 QVAATKTLPNGRDALDGPAAEAEPE 2629
Score = 82.8 bits (203), Expect = 9e-16
Identities = 80/306 (26%), Positives = 140/306 (45%), Gaps = 37/306 (12%)
Query: 291 EMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRL 350
E A+ +R++ E ++ + QA+ + +K R++ EQ RRA E+ LR
Sbjct: 2087 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQA-AAEKLRKEAEQEAARRAQAEQAALRQ 2145
Query: 351 QQLQE---EKERKLQELELLQEAQRQAE----RLLQEEEERRRSQHRELQQALEGQLREA 403
+Q + EK +K E L Q+AQ + E RL EE + +++ E Q L+ + EA
Sbjct: 2146 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2205
Query: 404 EQARASMQAEM---ELKEEEAARQRQRIK--------------------ELEEMQQRLQE 440
+ R+ ++ E+ ++ EE ++ + RI+ E E+M+Q +E
Sbjct: 2206 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2265
Query: 441 ALQLEVKARRDEESVRIAQTRLLEEE---EEKLKQLMQLKEEQERY---IERAQQEKEEL 494
A +L V A+ ++A+ L ++ E+ LK+ MQ +E R E QQ+KE
Sbjct: 2266 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA 2325
Query: 495 QQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRLMHPI 554
Q++ + +Q QQL E Q QR E Q ++ + +K +M+R
Sbjct: 2326 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2385
Query: 555 EPGDKR 560
E +R
Sbjct: 2386 EEDAQR 2391
Score = 81.6 bits (200), Expect = 2e-15
Identities = 75/298 (25%), Positives = 139/298 (46%), Gaps = 38/298 (12%)
Query: 288 RTYEMSASDTRQR-QEWTAAIQMAIRL---QAEGKTSLHKDLKQKRREQREQRERRRAAK 343
R E ++ R+R E AA++ +L A+ K ++ K+ ++ +E+ RR
Sbjct: 1335 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR---- 1390
Query: 344 EEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREA 403
EE + QQ + + +LQ+L EA+ QA+ E ER R + E + + QL
Sbjct: 1391 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1450
Query: 404 EQARASMQAEMEL----KEEEAARQRQRIKELEEMQQRLQEALQ--------------LE 445
E+ R + E++ EE A++RQ +E E +++++Q+ Q E
Sbjct: 1451 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1510
Query: 446 VKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYI----ERAQQEKE-ELQ----- 495
+A R+++ A L + EE ++L Q + E+ R + E AQ+ E ELQ
Sbjct: 1511 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1570
Query: 496 --QEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRLM 551
++ AQ RSLQ+ + ++R+ +R + A+R +A ++ W ++ N +
Sbjct: 1571 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1628
Score = 80.1 bits (196), Expect = 6e-15
Identities = 65/220 (29%), Positives = 109/220 (49%), Gaps = 23/220 (10%)
Query: 337 ERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQAL 396
E R +EEE L QQ EE+ER L E+E E QRQ + + + + +ELQQ +
Sbjct: 1325 ETLRRMEEEERLAEQQRAEERER-LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1383
Query: 397 EGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVR 456
+ ++ E+A Q + +EE + RQ + E+Q + ++A E R EE +R
Sbjct: 1384 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA--EIQAKARQAEAAERSRLRIEEEIR 1441
Query: 457 IAQTRLLEEEEEK------LKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQ 510
+ + +L E ++ L+ L EE E +AQ+E E L++++ +S+ +QA+
Sbjct: 1442 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1501
Query: 511 QLE-------EVRQNRQRADE-------DVEAAQRKLRQA 536
+L E + +QRA + E A+R+LRQA
Sbjct: 1502 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQA 1541
Score = 78.2 bits (191), Expect = 2e-14
Identities = 84/330 (25%), Positives = 153/330 (46%), Gaps = 58/330 (17%)
Query: 275 DGKRCMFCVKTANRTYEMSASDT-RQRQEWTAAIQMAIRLQAEGK-TSLHKDLKQKRREQ 332
+ R + A R +++ D RQR E A +A +L A G+ T L + + +E+
Sbjct: 1788 EAARLRALAEEAKRQRQLAEEDAARQRAE--AERVLAEKLAAIGEATRLKTEAEIALKEK 1845
Query: 333 REQRERRRAAKEEELLRLQQLQEEK-------ERKLQELELLQEAQRQAERLLQEEEERR 385
+ ER R E+E + ++L+E+ E +L +L +++ + ++ L E+ R+
Sbjct: 1846 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 1905
Query: 386 RSQHRELQQALEGQLREAEQARASMQAEM--------------ELKEEEAARQRQRIKEL 431
R Q E AL+ +A +A ++ E+ E E EAARQRQ E
Sbjct: 1906 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1965
Query: 432 E----EMQQRLQEALQLEVKARRDEESV---------RIAQTRLLEE--EEEKLKQLM-- 474
E E ++R+Q++L E +A R ++ ++ + R L E E+E +QL
Sbjct: 1966 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2025
Query: 475 ------QLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVR---QNRQRADED 525
+L+ E++ + QQ+++ELQQ +LQQ Q L+++R + +RA E+
Sbjct: 2026 QEAAQKRLQAEEKAHAFAVQQKEQELQQ-------TLQQEQSVLDQLRGEAEAARRAAEE 2078
Query: 526 VEAAQRKLRQASTNVKHWNVQMNRLMHPIE 555
E A+ + + + + + RL E
Sbjct: 2079 AEEARVQAEREAAQSRRQVEEAERLKQSAE 2108
Score = 78.2 bits (191), Expect = 2e-14
Identities = 72/254 (28%), Positives = 127/254 (50%), Gaps = 27/254 (10%)
Query: 291 EMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRL 350
E+ R E T + L+A + L + +++RR + E+R ++ A EEE R
Sbjct: 1931 ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE-EERRRREAEERVQKSLAAEEEAAR- 1988
Query: 351 QQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASM 410
+++ L+E+E L+ +A RL + E+ Q + Q+A + +L+ E+A A
Sbjct: 1989 -----QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2043
Query: 411 QAEMELKEEEAARQRQRIK-----ELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEE 465
+ E + ++ +Q Q + E E ++ +EA + V+A R+ AQ+R E
Sbjct: 2044 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA-----AQSRRQVE 2098
Query: 466 EEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADED 525
E E+LKQ EEQ + +AQ E+L++E Q++ QA+Q +RQ +Q AD +
Sbjct: 2099 EAERLKQSA---EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA--LRQ-KQAADAE 2152
Query: 526 VEA----AQRKLRQ 535
+E A++ LRQ
Sbjct: 2153 MEKHKKFAEQTLRQ 2166
Score = 76.6 bits (187), Expect = 6e-14
Identities = 77/302 (25%), Positives = 146/302 (48%), Gaps = 37/302 (12%)
Query: 251 EECKEKRGIIPLDAHCCVEVLPDRDGKRCMFCVKTANRTYEMSASDTRQRQ-EWTAAIQM 309
E ++++ + L + E R+ +R + ++ E + RQ + E +Q+
Sbjct: 1492 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1551
Query: 310 AIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQE 369
A+ + S +L+ KR E+ + + +EE + + QL+EE ER+ Q+ +
Sbjct: 1552 ALET---AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1608
Query: 370 AQRQAERLLQE------EEERRRSQHRELQQALEGQLREAEQARASMQAEMELK-----E 418
A+ +AER L+ E R R Q E+ Q + L +AE + +AE E + E
Sbjct: 1609 AREEAERELERWQLKANEALRLRLQAEEVAQ--QKSLAQAEAEKQKEEAEREARRRGKAE 1666
Query: 419 EEAARQRQRIK-ELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLK 477
E+A RQR+ + ELE+ +Q + Q + A ++E +R L E E+ +Q QL
Sbjct: 1667 EQAVRQRELAEQELEKQRQLAEGTAQQRLAA--EQELIR------LRAETEQGEQQRQLL 1718
Query: 478 EEQERYIER----AQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKL 533
EE+ ++R A Q+++EL+ E+A + + ++E + ++ RA+E+ + K
Sbjct: 1719 EEELARLQREAAAATQKRQELEAELA-------KVRAEMEVLLASKARAEEESRSTSEKS 1771
Query: 534 RQ 535
+Q
Sbjct: 1772 KQ 1773
Score = 74.3 bits (181), Expect = 3e-13
Identities = 81/293 (27%), Positives = 141/293 (48%), Gaps = 38/293 (12%)
Query: 284 KTANRTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQ---KRREQREQRERRR 340
+ A R + RQR+ ++ +L AEG +Q + R + EQ E++R
Sbjct: 1657 REARRRGKAEEQAVRQRELAEQELEKQRQL-AEGTAQQRLAAEQELIRLRAETEQGEQQR 1715
Query: 341 AAKEEELLRLQQLQEEKERKLQELEL-LQEAQRQAERLLQEE---EERRRSQHRELQQAL 396
EEEL RLQ+ +K QELE L + + + E LL + EE RS + +Q L
Sbjct: 1716 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1775
Query: 397 E---GQLRE-----------AEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEAL 442
E G+ RE AE+A+ Q L EE+AARQR E ++ L E L
Sbjct: 1776 EAEAGRFRELAEEAARLRALAEEAKRQRQ----LAEEDAARQR------AEAERVLAEKL 1825
Query: 443 QLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYI-ERAQQEKEELQQEMAQQ 501
+A R + IA + E E E+L++L + + Q R + E+A Q K ++++ +AQ
Sbjct: 1826 AAIGEATRLKTEAEIA-LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1884
Query: 502 SRS----LQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRL 550
++ L++ + +E+ + R++ +E++ A + +A+ +++ R+
Sbjct: 1885 RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1937
Score = 62.8 bits (151), Expect = 9e-10
Identities = 76/303 (25%), Positives = 138/303 (45%), Gaps = 61/303 (20%)
Query: 296 DTRQRQEWTAAIQMA----IRLQAEGKTSLHKDLKQKRRE----QREQRERRRAAKEEEL 347
D R+RQE A+ +A +R Q + +L +++++ + QR ++ A K+ EL
Sbjct: 1211 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYEL 1270
Query: 348 ---------------LRLQQLQEEKERKLQELELLQEAQRQ------------AERLLQE 380
+ ++Q E +QE L+ + +E L +
Sbjct: 1271 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1330
Query: 381 EEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQE 440
EEE R ++ QQ E + R AE A+++ + +L E A + Q +E +E+QQR+QE
Sbjct: 1331 EEEERLAE----QQRAEERERLAE-VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE 1385
Query: 441 ALQLEVKARRDEESVRI-AQTRLLEEEEEKLKQL----MQLKEEQERYIERAQQEKEE-- 493
+ RR+E +V Q R ++EE ++L+Q +Q K Q ER++ EE
Sbjct: 1386 EV-----VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1440
Query: 494 ----LQQEMAQQSR-----SLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWN 544
LQ E ++ R LQ + + EE +++A E+ E +R+++ S +
Sbjct: 1441 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1500
Query: 545 VQM 547
V++
Sbjct: 1501 VEL 1503
Score = 45.1 bits (105), Expect = 2e-04
Identities = 45/154 (29%), Positives = 72/154 (46%), Gaps = 12/154 (7%)
Query: 336 RERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQA 395
R AK+E L + E KE+K++EL Q +RLL+E+ R + Q A
Sbjct: 633 RNTNMTAKKESYSALMRELELKEKKIKEL------QNAGDRLLREDHPARPTV-ESFQAA 685
Query: 396 LEGQLREAEQARASMQAEMELKEEEAARQ-RQRIKELEEMQQRLQEALQLEVKARRDEES 454
L+ Q Q ++A LKE A Q ++E E Q+LQEAL+ + R
Sbjct: 686 LQTQWSWMLQLCCCIEA--HLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 743
Query: 455 VRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQ 488
R+ LL++ +++ +QL + K +RA+
Sbjct: 744 TRLED--LLQDAQDEKEQLNEYKGHLSGLAKRAK 775
Score = 38.9 bits (89), Expect = 0.015
Identities = 68/281 (24%), Positives = 125/281 (44%), Gaps = 44/281 (15%)
Query: 274 RDGKRCMFCV-KTANRTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQ 332
++ RC C+ + + ++ A +TR ++ + L E + + ++++ Q
Sbjct: 963 QEESRCQRCISELKDIRLQLEACETR------TVHRLRLPLDKEPARECAQRIAEQQKAQ 1016
Query: 333 RE-----QRERRRAAKEEELLRLQQ-------LQEEKERKLQELELLQEAQR-QAERLLQ 379
E + R +A+ E++L L + L+ E E L +LE ++ E+L
Sbjct: 1017 AEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKT 1076
Query: 380 EEEERRRSQH-RELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRL 438
R +Q E+ +A E QL+EA+ A++ EL+ +A+ ++ R +
Sbjct: 1077 ISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP---ELEATKASLKKLRAQA-------- 1125
Query: 439 QEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKE-EQERYIERAQQEKEELQQE 497
EA Q A RDE R +E E+L+Q ++ E ER+ ER Q E Q
Sbjct: 1126 -EAQQPTFDALRDE-------LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAV 1177
Query: 498 MAQ---QSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQ 535
+AQ + R L+Q +QL R++ ++ A+R+ Q
Sbjct: 1178 LAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1218
Score = 38.5 bits (88), Expect = 0.019
Identities = 59/265 (22%), Positives = 117/265 (44%), Gaps = 36/265 (13%)
Query: 312 RLQAE---GKTSLHKDLKQKRREQREQRERR--RAAKEEELLRLQQLQEEKERKLQELEL 366
RL AE G S H + EQ Q E R R E + +RLQ L+ + R + L L
Sbjct: 937 RLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQ-LEACETRTVHRLRL 995
Query: 367 ---LQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARA---------SMQAEM 414
+ A+ A+R+ E+++ +++ L + + EAE+ A ++++E+
Sbjct: 996 PLDKEPARECAQRIA--EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL 1053
Query: 415 ELK----EEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQT-----RLLEE 465
EL E+ + +++L+ + ++ E R EE ++ AQ LE
Sbjct: 1054 ELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1113
Query: 466 EEEKLKQLMQLKEEQERYIER-------AQQEKEELQQEMAQQSRSLQQAQQQLEEVRQN 518
+ LK+L E Q+ + AQ+ E LQQ ++ +++ ++++ ++ +
Sbjct: 1114 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1173
Query: 519 RQRADEDVEAAQRKLRQASTNVKHW 543
Q + QR+L Q ++++
Sbjct: 1174 WQAVLAQTDVRQRELEQLGRQLRYY 1198
Score = 37.4 bits (85), Expect = 0.042
Identities = 45/184 (24%), Positives = 80/184 (43%), Gaps = 17/184 (9%)
Query: 342 AKEEELLRLQQLQ------EEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQA 395
A EE+L Q + E + L++L EAQ+ L++E + LQQ
Sbjct: 1093 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1152
Query: 396 LEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLE-------VKA 448
+ E E+ R + +E + A+ R +ELE++ ++L+ + A
Sbjct: 1153 HGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA 1212
Query: 449 RRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQA 508
RR +E ++ + E+L+Q L EE ER+ E+ EE Q+ Q +++
Sbjct: 1213 RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKV----EECQRFAKQYINAIKDY 1268
Query: 509 QQQL 512
+ QL
Sbjct: 1269 ELQL 1272
Score = 31.2 bits (69), Expect = 3.0
Identities = 47/203 (23%), Positives = 84/203 (41%), Gaps = 20/203 (9%)
Query: 339 RRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEG 398
R E RL+ LQ + E L +E QA+ LLQ + R + + Q+A E
Sbjct: 366 REKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQ-SDVRLLAAGKVPQRAGEV 424
Query: 399 QLREAEQARA-------SMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRD 451
+ R+ ++A + +Q + + + + +R+ L E ++ L +KA
Sbjct: 425 E-RDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVA 483
Query: 452 EESVRIAQTRLL------EEEEEKLKQLMQL---KEEQERYIERAQQEKEELQQEMAQQS 502
+ ++AQ L E E+ L+ L L EE + ++ A+ + + Q
Sbjct: 484 APATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVD--LPSVEAQL 541
Query: 503 RSLQQAQQQLEEVRQNRQRADED 525
S + Q +EE R +RA D
Sbjct: 542 GSHRGLHQSIEEFRAKIERARSD 564
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 92.4 bits (228), Expect = 1e-18
Identities = 77/291 (26%), Positives = 144/291 (49%), Gaps = 34/291 (11%)
Query: 291 EMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQ-RERRRAAKEEELLR 349
E + + RQ QE ++ ++ +++ K +L + + + E RE++RA + E LR
Sbjct: 1510 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1569
Query: 350 LQQLQEEKERKLQELEL---------LQEAQRQAERLLQEEEERRRSQHRELQQALE--- 397
LQ EE ER+L++ E+ L+ AQR AE LQ + + +L+++L+
Sbjct: 1570 LQA--EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEH 1627
Query: 398 ---GQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEES 454
QLRE + RA QAE E EEA R ELE Q + EAL+L ++A +
Sbjct: 1628 VAVAQLREEAERRAQQQAEAERAREEAER------ELERWQLKANEALRLRLQAEEVAQQ 1681
Query: 455 VRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQ---AQQQ 511
+AQ +++EE ++ + + +E+ + + + ++EL+++ + QQ A+Q+
Sbjct: 1682 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1741
Query: 512 L-------EEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRLMHPIE 555
L E+ Q RQ +E++ QR+ A+ + ++ ++ +E
Sbjct: 1742 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1792
Score = 87.0 bits (214), Expect = 5e-17
Identities = 76/268 (28%), Positives = 133/268 (49%), Gaps = 26/268 (9%)
Query: 288 RTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQR-------ERRR 340
R E +A +E A ++ A + E + L +D ++RR+ E+ E+
Sbjct: 1906 RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1965
Query: 341 AAKEE---ELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALE 397
A K E EL R++ E+ R ++ EL QRQ L EEE RRR +Q++L
Sbjct: 1966 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ---LAAEEERRRREAEERVQKSLA 2022
Query: 398 GQLREAEQARASMQ--AEMELKEEEAARQRQR-----IKELEEMQQRLQEALQLEVKARR 450
+ A Q +A+++ ++ K EEA R R+R ++L+ Q+ Q+ LQ E KA
Sbjct: 2023 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2082
Query: 451 ---DEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQ 507
++ + QT L++E+ L QL E R E A++ + + ++E AQ R +++
Sbjct: 2083 FAVQQKEQELQQT--LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2140
Query: 508 AQQQLEEVRQNRQRADEDVEAAQRKLRQ 535
A ++L++ + + +A +AA KLR+
Sbjct: 2141 A-ERLKQSAEEQAQARAQAQAAAEKLRK 2167
Score = 86.7 bits (213), Expect = 6e-17
Identities = 75/282 (26%), Positives = 136/282 (48%), Gaps = 27/282 (9%)
Query: 286 ANRTYEMSASDTRQRQEWTAAIQMAIRLQAEG----KTSLHK--DLKQKRREQREQRERR 339
A R +++A + R+R+E +Q ++ + E K +L + LK K E R RER
Sbjct: 1996 AARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRER- 2054
Query: 340 RAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQ 399
A++E +LQ QE +++LQ A+ +A +++E+ Q + +Q++ Q
Sbjct: 2055 --AEQESARQLQLAQEAAQKRLQ-------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2105
Query: 400 LR-EAEQARASMQAEMELK---EEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESV 455
LR EAE AR + + E + E EAA+ R++++E E ++Q +E Q +A+ E +
Sbjct: 2106 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2165
Query: 456 R----IAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQ---EKEELQQEMAQQSRSLQQA 508
R R + E+ L+Q E E++ + A+Q +K +++QE+ L++
Sbjct: 2166 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2225
Query: 509 QQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRL 550
Q + + QR + A R+ Q + VQM L
Sbjct: 2226 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2267
Score = 84.3 bits (207), Expect = 3e-16
Identities = 98/385 (25%), Positives = 178/385 (46%), Gaps = 54/385 (14%)
Query: 288 RTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRR-EQREQRERRRAAKEEE 346
R + A +Q E A + +A + A + +DL Q+R ++ +E+ +A +E
Sbjct: 2291 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2350
Query: 347 LLRLQQ--LQEEKERKLQELELLQEAQRQ-AERLLQEEEERRRSQHRELQQALEG----- 398
L+ + LQ++KE ++ LQE + Q A++L +E + +R+ E Q+ LE
Sbjct: 2351 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2410
Query: 399 --QLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEV---------K 447
+LR AE +RA +AE E+A R R++ +E+ E R + A Q +V +
Sbjct: 2411 RLKLRVAEMSRAQARAE-----EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQR 2465
Query: 448 ARRDEESVRIAQT-RLLEEEEEKLKQ---LMQLKEEQERYIERAQ--QEKEELQQ----- 496
+ D ++ R+ + LE E+EKL+Q L+QLK E+ + +++ Q QE + LQQ
Sbjct: 2466 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2525
Query: 497 --EMAQQSRSLQQAQQQLEEVRQNR----QRADEDVEAAQRKLRQASTNVKHWNVQMNRL 550
+ Q+ R ++Q + +LE++ Q+ Q+ E+ + Q+++ Q + + R
Sbjct: 2526 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRR 2585
Query: 551 MHPIEPGDKRPVTS----SSFSGFQPPLLAHRDSSLKRLTRWGSQGNRTPSPNSNEQQKS 606
H E G +R Q LLA + L+ + + +R +S E S
Sbjct: 2586 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2645
Query: 607 L--------NGGDEAPAPASTPQED 623
NG D PA+ + +
Sbjct: 2646 QVAATKTLPNGRDALDGPAAEAEPE 2670
Score = 82.8 bits (203), Expect = 9e-16
Identities = 80/306 (26%), Positives = 140/306 (45%), Gaps = 37/306 (12%)
Query: 291 EMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRL 350
E A+ +R++ E ++ + QA+ + +K R++ EQ RRA E+ LR
Sbjct: 2128 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQA-AAEKLRKEAEQEAARRAQAEQAALRQ 2186
Query: 351 QQLQE---EKERKLQELELLQEAQRQAE----RLLQEEEERRRSQHRELQQALEGQLREA 403
+Q + EK +K E L Q+AQ + E RL EE + +++ E Q L+ + EA
Sbjct: 2187 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2246
Query: 404 EQARASMQAEM---ELKEEEAARQRQRIK--------------------ELEEMQQRLQE 440
+ R+ ++ E+ ++ EE ++ + RI+ E E+M+Q +E
Sbjct: 2247 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2306
Query: 441 ALQLEVKARRDEESVRIAQTRLLEEE---EEKLKQLMQLKEEQERY---IERAQQEKEEL 494
A +L V A+ ++A+ L ++ E+ LK+ MQ +E R E QQ+KE
Sbjct: 2307 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA 2366
Query: 495 QQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRLMHPI 554
Q++ + +Q QQL E Q QR E Q ++ + +K +M+R
Sbjct: 2367 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2426
Query: 555 EPGDKR 560
E +R
Sbjct: 2427 EEDAQR 2432
Score = 81.6 bits (200), Expect = 2e-15
Identities = 75/298 (25%), Positives = 139/298 (46%), Gaps = 38/298 (12%)
Query: 288 RTYEMSASDTRQR-QEWTAAIQMAIRL---QAEGKTSLHKDLKQKRREQREQRERRRAAK 343
R E ++ R+R E AA++ +L A+ K ++ K+ ++ +E+ RR
Sbjct: 1376 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR---- 1431
Query: 344 EEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREA 403
EE + QQ + + +LQ+L EA+ QA+ E ER R + E + + QL
Sbjct: 1432 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1491
Query: 404 EQARASMQAEMEL----KEEEAARQRQRIKELEEMQQRLQEALQ--------------LE 445
E+ R + E++ EE A++RQ +E E +++++Q+ Q E
Sbjct: 1492 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1551
Query: 446 VKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYI----ERAQQEKE-ELQ----- 495
+A R+++ A L + EE ++L Q + E+ R + E AQ+ E ELQ
Sbjct: 1552 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1611
Query: 496 --QEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRLM 551
++ AQ RSLQ+ + ++R+ +R + A+R +A ++ W ++ N +
Sbjct: 1612 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1669
Score = 80.1 bits (196), Expect = 6e-15
Identities = 65/220 (29%), Positives = 109/220 (49%), Gaps = 23/220 (10%)
Query: 337 ERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQAL 396
E R +EEE L QQ EE+ER L E+E E QRQ + + + + +ELQQ +
Sbjct: 1366 ETLRRMEEEERLAEQQRAEERER-LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1424
Query: 397 EGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVR 456
+ ++ E+A Q + +EE + RQ + E+Q + ++A E R EE +R
Sbjct: 1425 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA--EIQAKARQAEAAERSRLRIEEEIR 1482
Query: 457 IAQTRLLEEEEEK------LKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQ 510
+ + +L E ++ L+ L EE E +AQ+E E L++++ +S+ +QA+
Sbjct: 1483 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1542
Query: 511 QLE-------EVRQNRQRADE-------DVEAAQRKLRQA 536
+L E + +QRA + E A+R+LRQA
Sbjct: 1543 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQA 1582
Score = 78.2 bits (191), Expect = 2e-14
Identities = 84/330 (25%), Positives = 153/330 (46%), Gaps = 58/330 (17%)
Query: 275 DGKRCMFCVKTANRTYEMSASDT-RQRQEWTAAIQMAIRLQAEGK-TSLHKDLKQKRREQ 332
+ R + A R +++ D RQR E A +A +L A G+ T L + + +E+
Sbjct: 1829 EAARLRALAEEAKRQRQLAEEDAARQRAE--AERVLAEKLAAIGEATRLKTEAEIALKEK 1886
Query: 333 REQRERRRAAKEEELLRLQQLQEEK-------ERKLQELELLQEAQRQAERLLQEEEERR 385
+ ER R E+E + ++L+E+ E +L +L +++ + ++ L E+ R+
Sbjct: 1887 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 1946
Query: 386 RSQHRELQQALEGQLREAEQARASMQAEM--------------ELKEEEAARQRQRIKEL 431
R Q E AL+ +A +A ++ E+ E E EAARQRQ E
Sbjct: 1947 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 2006
Query: 432 E----EMQQRLQEALQLEVKARRDEESV---------RIAQTRLLEE--EEEKLKQLM-- 474
E E ++R+Q++L E +A R ++ ++ + R L E E+E +QL
Sbjct: 2007 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2066
Query: 475 ------QLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVR---QNRQRADED 525
+L+ E++ + QQ+++ELQQ +LQQ Q L+++R + +RA E+
Sbjct: 2067 QEAAQKRLQAEEKAHAFAVQQKEQELQQ-------TLQQEQSVLDQLRGEAEAARRAAEE 2119
Query: 526 VEAAQRKLRQASTNVKHWNVQMNRLMHPIE 555
E A+ + + + + + RL E
Sbjct: 2120 AEEARVQAEREAAQSRRQVEEAERLKQSAE 2149
Score = 78.2 bits (191), Expect = 2e-14
Identities = 72/254 (28%), Positives = 127/254 (50%), Gaps = 27/254 (10%)
Query: 291 EMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRL 350
E+ R E T + L+A + L + +++RR + E+R ++ A EEE R
Sbjct: 1972 ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE-EERRRREAEERVQKSLAAEEEAAR- 2029
Query: 351 QQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASM 410
+++ L+E+E L+ +A RL + E+ Q + Q+A + +L+ E+A A
Sbjct: 2030 -----QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2084
Query: 411 QAEMELKEEEAARQRQRIK-----ELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEE 465
+ E + ++ +Q Q + E E ++ +EA + V+A R+ AQ+R E
Sbjct: 2085 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA-----AQSRRQVE 2139
Query: 466 EEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADED 525
E E+LKQ EEQ + +AQ E+L++E Q++ QA+Q +RQ +Q AD +
Sbjct: 2140 EAERLKQSA---EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA--LRQ-KQAADAE 2193
Query: 526 VEA----AQRKLRQ 535
+E A++ LRQ
Sbjct: 2194 MEKHKKFAEQTLRQ 2207
Score = 76.6 bits (187), Expect = 6e-14
Identities = 77/302 (25%), Positives = 146/302 (48%), Gaps = 37/302 (12%)
Query: 251 EECKEKRGIIPLDAHCCVEVLPDRDGKRCMFCVKTANRTYEMSASDTRQRQ-EWTAAIQM 309
E ++++ + L + E R+ +R + ++ E + RQ + E +Q+
Sbjct: 1533 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1592
Query: 310 AIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQE 369
A+ + S +L+ KR E+ + + +EE + + QL+EE ER+ Q+ +
Sbjct: 1593 ALET---AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1649
Query: 370 AQRQAERLLQE------EEERRRSQHRELQQALEGQLREAEQARASMQAEMELK-----E 418
A+ +AER L+ E R R Q E+ Q + L +AE + +AE E + E
Sbjct: 1650 AREEAERELERWQLKANEALRLRLQAEEVAQ--QKSLAQAEAEKQKEEAEREARRRGKAE 1707
Query: 419 EEAARQRQRIK-ELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLK 477
E+A RQR+ + ELE+ +Q + Q + A ++E +R L E E+ +Q QL
Sbjct: 1708 EQAVRQRELAEQELEKQRQLAEGTAQQRLAA--EQELIR------LRAETEQGEQQRQLL 1759
Query: 478 EEQERYIER----AQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKL 533
EE+ ++R A Q+++EL+ E+A + + ++E + ++ RA+E+ + K
Sbjct: 1760 EEELARLQREAAAATQKRQELEAELA-------KVRAEMEVLLASKARAEEESRSTSEKS 1812
Query: 534 RQ 535
+Q
Sbjct: 1813 KQ 1814
Score = 74.3 bits (181), Expect = 3e-13
Identities = 81/293 (27%), Positives = 141/293 (48%), Gaps = 38/293 (12%)
Query: 284 KTANRTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQ---KRREQREQRERRR 340
+ A R + RQR+ ++ +L AEG +Q + R + EQ E++R
Sbjct: 1698 REARRRGKAEEQAVRQRELAEQELEKQRQL-AEGTAQQRLAAEQELIRLRAETEQGEQQR 1756
Query: 341 AAKEEELLRLQQLQEEKERKLQELEL-LQEAQRQAERLLQEE---EERRRSQHRELQQAL 396
EEEL RLQ+ +K QELE L + + + E LL + EE RS + +Q L
Sbjct: 1757 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1816
Query: 397 E---GQLRE-----------AEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEAL 442
E G+ RE AE+A+ Q L EE+AARQR E ++ L E L
Sbjct: 1817 EAEAGRFRELAEEAARLRALAEEAKRQRQ----LAEEDAARQR------AEAERVLAEKL 1866
Query: 443 QLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYI-ERAQQEKEELQQEMAQQ 501
+A R + IA + E E E+L++L + + Q R + E+A Q K ++++ +AQ
Sbjct: 1867 AAIGEATRLKTEAEIA-LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1925
Query: 502 SRS----LQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRL 550
++ L++ + +E+ + R++ +E++ A + +A+ +++ R+
Sbjct: 1926 RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1978
Score = 62.8 bits (151), Expect = 9e-10
Identities = 76/303 (25%), Positives = 138/303 (45%), Gaps = 61/303 (20%)
Query: 296 DTRQRQEWTAAIQMA----IRLQAEGKTSLHKDLKQKRRE----QREQRERRRAAKEEEL 347
D R+RQE A+ +A +R Q + +L +++++ + QR ++ A K+ EL
Sbjct: 1252 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYEL 1311
Query: 348 ---------------LRLQQLQEEKERKLQELELLQEAQRQ------------AERLLQE 380
+ ++Q E +QE L+ + +E L +
Sbjct: 1312 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1371
Query: 381 EEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQE 440
EEE R ++ QQ E + R AE A+++ + +L E A + Q +E +E+QQR+QE
Sbjct: 1372 EEEERLAE----QQRAEERERLAE-VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE 1426
Query: 441 ALQLEVKARRDEESVRI-AQTRLLEEEEEKLKQL----MQLKEEQERYIERAQQEKEE-- 493
+ RR+E +V Q R ++EE ++L+Q +Q K Q ER++ EE
Sbjct: 1427 EV-----VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1481
Query: 494 ----LQQEMAQQSR-----SLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWN 544
LQ E ++ R LQ + + EE +++A E+ E +R+++ S +
Sbjct: 1482 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1541
Query: 545 VQM 547
V++
Sbjct: 1542 VEL 1544
Score = 45.1 bits (105), Expect = 2e-04
Identities = 45/154 (29%), Positives = 72/154 (46%), Gaps = 12/154 (7%)
Query: 336 RERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQA 395
R AK+E L + E KE+K++EL Q +RLL+E+ R + Q A
Sbjct: 674 RNTNMTAKKESYSALMRELELKEKKIKEL------QNAGDRLLREDHPARPTV-ESFQAA 726
Query: 396 LEGQLREAEQARASMQAEMELKEEEAARQ-RQRIKELEEMQQRLQEALQLEVKARRDEES 454
L+ Q Q ++A LKE A Q ++E E Q+LQEAL+ + R
Sbjct: 727 LQTQWSWMLQLCCCIEA--HLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 784
Query: 455 VRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQ 488
R+ LL++ +++ +QL + K +RA+
Sbjct: 785 TRLED--LLQDAQDEKEQLNEYKGHLSGLAKRAK 816
Score = 38.9 bits (89), Expect = 0.015
Identities = 68/281 (24%), Positives = 125/281 (44%), Gaps = 44/281 (15%)
Query: 274 RDGKRCMFCV-KTANRTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQ 332
++ RC C+ + + ++ A +TR ++ + L E + + ++++ Q
Sbjct: 1004 QEESRCQRCISELKDIRLQLEACETR------TVHRLRLPLDKEPARECAQRIAEQQKAQ 1057
Query: 333 RE-----QRERRRAAKEEELLRLQQ-------LQEEKERKLQELELLQEAQR-QAERLLQ 379
E + R +A+ E++L L + L+ E E L +LE ++ E+L
Sbjct: 1058 AEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKT 1117
Query: 380 EEEERRRSQH-RELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRL 438
R +Q E+ +A E QL+EA+ A++ EL+ +A+ ++ R +
Sbjct: 1118 ISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP---ELEATKASLKKLRAQA-------- 1166
Query: 439 QEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKE-EQERYIERAQQEKEELQQE 497
EA Q A RDE R +E E+L+Q ++ E ER+ ER Q E Q
Sbjct: 1167 -EAQQPTFDALRDE-------LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAV 1218
Query: 498 MAQ---QSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQ 535
+AQ + R L+Q +QL R++ ++ A+R+ Q
Sbjct: 1219 LAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1259
Score = 38.5 bits (88), Expect = 0.019
Identities = 59/265 (22%), Positives = 117/265 (44%), Gaps = 36/265 (13%)
Query: 312 RLQAE---GKTSLHKDLKQKRREQREQRERR--RAAKEEELLRLQQLQEEKERKLQELEL 366
RL AE G S H + EQ Q E R R E + +RLQ L+ + R + L L
Sbjct: 978 RLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQ-LEACETRTVHRLRL 1036
Query: 367 ---LQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARA---------SMQAEM 414
+ A+ A+R+ E+++ +++ L + + EAE+ A ++++E+
Sbjct: 1037 PLDKEPARECAQRIA--EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL 1094
Query: 415 ELK----EEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQT-----RLLEE 465
EL E+ + +++L+ + ++ E R EE ++ AQ LE
Sbjct: 1095 ELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1154
Query: 466 EEEKLKQLMQLKEEQERYIER-------AQQEKEELQQEMAQQSRSLQQAQQQLEEVRQN 518
+ LK+L E Q+ + AQ+ E LQQ ++ +++ ++++ ++ +
Sbjct: 1155 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1214
Query: 519 RQRADEDVEAAQRKLRQASTNVKHW 543
Q + QR+L Q ++++
Sbjct: 1215 WQAVLAQTDVRQRELEQLGRQLRYY 1239
Score = 37.4 bits (85), Expect = 0.042
Identities = 45/184 (24%), Positives = 80/184 (43%), Gaps = 17/184 (9%)
Query: 342 AKEEELLRLQQLQ------EEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQA 395
A EE+L Q + E + L++L EAQ+ L++E + LQQ
Sbjct: 1134 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1193
Query: 396 LEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLE-------VKA 448
+ E E+ R + +E + A+ R +ELE++ ++L+ + A
Sbjct: 1194 HGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA 1253
Query: 449 RRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQA 508
RR +E ++ + E+L+Q L EE ER+ E+ EE Q+ Q +++
Sbjct: 1254 RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKV----EECQRFAKQYINAIKDY 1309
Query: 509 QQQL 512
+ QL
Sbjct: 1310 ELQL 1313
Score = 31.2 bits (69), Expect = 3.0
Identities = 47/203 (23%), Positives = 84/203 (41%), Gaps = 20/203 (9%)
Query: 339 RRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEG 398
R E RL+ LQ + E L +E QA+ LLQ + R + + Q+A E
Sbjct: 407 REKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQ-SDVRLLAAGKVPQRAGEV 465
Query: 399 QLREAEQARA-------SMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRD 451
+ R+ ++A + +Q + + + + +R+ L E ++ L +KA
Sbjct: 466 E-RDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVA 524
Query: 452 EESVRIAQTRLL------EEEEEKLKQLMQL---KEEQERYIERAQQEKEELQQEMAQQS 502
+ ++AQ L E E+ L+ L L EE + ++ A+ + + Q
Sbjct: 525 APATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVD--LPSVEAQL 582
Query: 503 RSLQQAQQQLEEVRQNRQRADED 525
S + Q +EE R +RA D
Sbjct: 583 GSHRGLHQSIEEFRAKIERARSD 605
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
sapiens]
Length = 1293
Score = 91.7 bits (226), Expect = 2e-18
Identities = 74/228 (32%), Positives = 126/228 (55%), Gaps = 27/228 (11%)
Query: 331 EQREQRERRRAAKEEELLRLQQLQ---EEKERKLQELELLQEAQRQAERLL--QEEEERR 385
EQ +Q E+ +AAK E+ R +++ EE+ERK QE E +RQ E +L Q+EEER+
Sbjct: 718 EQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQE-----ELRRQQEEILRRQQEEERK 772
Query: 386 RSQHREL-----QQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQE 440
R + EL ++AL Q RE E A + E E +++E A +R + EE ++R QE
Sbjct: 773 RREEEELARRKQEEALRRQ-REQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQE 831
Query: 441 ALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQ 500
E+ +++EE+ + A+ EE + +L++ EE+ + ++E++ + E+ +
Sbjct: 832 ----ELLRKQEEEAAKWAREE--EEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQR 885
Query: 501 QSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMN 548
Q ++Q QQQ E +R+ +Q+ + + AQ KL +ST W Q N
Sbjct: 886 QKELMRQRQQQQEALRRLQQQQQQQ-QLAQMKLPSSST----WGQQSN 928
Score = 88.2 bits (217), Expect = 2e-17
Identities = 66/209 (31%), Positives = 115/209 (55%), Gaps = 25/209 (11%)
Query: 310 AIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQEL----- 364
A +L+ E + + +++ KR E+ +R+ ++EE+LR QQ +E K R+ +EL
Sbjct: 728 AAKLEQERREA---EMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQ 784
Query: 365 -ELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAAR 423
E L+ + Q L ++ EE R Q E + LE + RE E+ R Q E+ K+EE A
Sbjct: 785 EEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRK--QEELLRKQEEEAA 842
Query: 424 QRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERY 483
+ R E EE Q+RL+E + R +EE+ R L EEEE+ ++ ++++ ++E
Sbjct: 843 KWAR--EEEEAQRRLEEN-----RLRMEEEAAR-----LRHEEEERKRKELEVQRQKE-- 888
Query: 484 IERAQQEKEELQQEMAQQSRSLQQAQQQL 512
+ R +Q+++E + + QQ + Q AQ +L
Sbjct: 889 LMRQRQQQQEALRRLQQQQQQQQLAQMKL 917
Score = 84.0 bits (206), Expect = 4e-16
Identities = 68/263 (25%), Positives = 134/263 (50%), Gaps = 47/263 (17%)
Query: 308 QMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELL 367
++A R Q E +L + +Q+ +R++ E R +EE L RL++ + E+E + ++ ELL
Sbjct: 778 ELARRKQEE---ALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELL 834
Query: 368 QEAQRQAERLLQEEEE--RRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQR 425
++ + +A + +EEEE RR ++R + +LR E+ R + E++ +++E RQR
Sbjct: 835 RKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQ-RQKELMRQR 893
Query: 426 QRIKE-LEEMQQRLQEALQLEVK--------------ARRDEESVRIAQTRLLEEEEEKL 470
Q+ +E L +QQ+ Q+ ++K A + + ++ +A+ + LEEE E+
Sbjct: 894 QQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERER- 952
Query: 471 KQLMQLKEEQERYIERAQQEKE------------------------ELQQEMAQQSRSLQ 506
QL + + Q+R + +A Q+++ E+QQE A+Q + Q
Sbjct: 953 -QLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQ 1011
Query: 507 QAQQQLEEVRQNRQRADEDVEAA 529
Q QQQ ++ + R ++ +
Sbjct: 1012 QQQQQHQQPNRARNNTHSNLHTS 1034
Score = 66.2 bits (160), Expect = 8e-11
Identities = 66/251 (26%), Positives = 119/251 (47%), Gaps = 39/251 (15%)
Query: 347 LLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQA 406
L +LQQL++ K KL++ +EA+ +A+R EEEER+R + QQ
Sbjct: 717 LEQLQQLEKAKAAKLEQER--REAEMRAKR---EEEERKRQEELRRQQE----------- 760
Query: 407 RASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEE 466
E+ + +R+R +E E +++ +EAL+ R+ E+ + + + R EE
Sbjct: 761 --------EILRRQQEEERKRREEEELARRKQEEALR-----RQREQEIALRRQREEEER 807
Query: 467 EEKLKQLMQLKEEQERYIERAQQEK--EELQQEMAQQSRSLQQAQQQLEEVRQNRQRADE 524
+++ + L +L+E + ER +QE+ + ++E A+ +R ++AQ++LEE NR R +E
Sbjct: 808 QQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEE---NRLRMEE 864
Query: 525 DVEAAQRKLRQASTNVKHWNVQMNRLMHPIEPGDKRPVTSSSFSGFQPPLLAHRDSSLKR 584
EAA+ + + K VQ + + + + Q L L
Sbjct: 865 --EAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQL---AQMKLPS 919
Query: 585 LTRWGSQGNRT 595
+ WG Q N T
Sbjct: 920 SSTWGQQSNTT 930
Score = 38.5 bits (88), Expect = 0.019
Identities = 40/206 (19%), Positives = 83/206 (40%), Gaps = 33/206 (16%)
Query: 314 QAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQE---------- 363
Q++ SL + K + +R+ RE +R + E + LQQ Q+++++KL
Sbjct: 933 QSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGT 992
Query: 364 ----LELLQEAQRQAERLLQEEEER------RRSQHRELQQALEGQL----------REA 403
LE+ QE RQ ++ Q++++ R + H L ++ + + A
Sbjct: 993 TKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLHTSIGNSVWGSINTGPPNQWA 1052
Query: 404 EQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLL 463
+S+ + + K +KE+ + + V Q + +
Sbjct: 1053 SDLVSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSK---SVGVSNRQNKKV 1109
Query: 464 EEEEEKLKQLMQLKEEQERYIERAQQ 489
EEEE+ LK + + Q+ + + +Q
Sbjct: 1110 EEEEKLLKLFQGVNKAQDGFTQWCEQ 1135
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
sapiens]
Length = 1320
Score = 91.7 bits (226), Expect = 2e-18
Identities = 74/228 (32%), Positives = 126/228 (55%), Gaps = 27/228 (11%)
Query: 331 EQREQRERRRAAKEEELLRLQQLQ---EEKERKLQELELLQEAQRQAERLL--QEEEERR 385
EQ +Q E+ +AAK E+ R +++ EE+ERK QE E +RQ E +L Q+EEER+
Sbjct: 745 EQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQE-----ELRRQQEEILRRQQEEERK 799
Query: 386 RSQHREL-----QQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQE 440
R + EL ++AL Q RE E A + E E +++E A +R + EE ++R QE
Sbjct: 800 RREEEELARRKQEEALRRQ-REQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQE 858
Query: 441 ALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQ 500
E+ +++EE+ + A+ EE + +L++ EE+ + ++E++ + E+ +
Sbjct: 859 ----ELLRKQEEEAAKWAREE--EEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQR 912
Query: 501 QSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMN 548
Q ++Q QQQ E +R+ +Q+ + + AQ KL +ST W Q N
Sbjct: 913 QKELMRQRQQQQEALRRLQQQQQQQ-QLAQMKLPSSST----WGQQSN 955
Score = 88.2 bits (217), Expect = 2e-17
Identities = 66/209 (31%), Positives = 115/209 (55%), Gaps = 25/209 (11%)
Query: 310 AIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQEL----- 364
A +L+ E + + +++ KR E+ +R+ ++EE+LR QQ +E K R+ +EL
Sbjct: 755 AAKLEQERREA---EMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQ 811
Query: 365 -ELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAAR 423
E L+ + Q L ++ EE R Q E + LE + RE E+ R Q E+ K+EE A
Sbjct: 812 EEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRK--QEELLRKQEEEAA 869
Query: 424 QRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERY 483
+ R E EE Q+RL+E + R +EE+ R L EEEE+ ++ ++++ ++E
Sbjct: 870 KWAR--EEEEAQRRLEEN-----RLRMEEEAAR-----LRHEEEERKRKELEVQRQKE-- 915
Query: 484 IERAQQEKEELQQEMAQQSRSLQQAQQQL 512
+ R +Q+++E + + QQ + Q AQ +L
Sbjct: 916 LMRQRQQQQEALRRLQQQQQQQQLAQMKL 944
Score = 84.0 bits (206), Expect = 4e-16
Identities = 68/263 (25%), Positives = 134/263 (50%), Gaps = 47/263 (17%)
Query: 308 QMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELL 367
++A R Q E +L + +Q+ +R++ E R +EE L RL++ + E+E + ++ ELL
Sbjct: 805 ELARRKQEE---ALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELL 861
Query: 368 QEAQRQAERLLQEEEE--RRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQR 425
++ + +A + +EEEE RR ++R + +LR E+ R + E++ +++E RQR
Sbjct: 862 RKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQ-RQKELMRQR 920
Query: 426 QRIKE-LEEMQQRLQEALQLEVK--------------ARRDEESVRIAQTRLLEEEEEKL 470
Q+ +E L +QQ+ Q+ ++K A + + ++ +A+ + LEEE E+
Sbjct: 921 QQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERER- 979
Query: 471 KQLMQLKEEQERYIERAQQEKE------------------------ELQQEMAQQSRSLQ 506
QL + + Q+R + +A Q+++ E+QQE A+Q + Q
Sbjct: 980 -QLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQ 1038
Query: 507 QAQQQLEEVRQNRQRADEDVEAA 529
Q QQQ ++ + R ++ +
Sbjct: 1039 QQQQQHQQPNRARNNTHSNLHTS 1061
Score = 66.2 bits (160), Expect = 8e-11
Identities = 66/251 (26%), Positives = 119/251 (47%), Gaps = 39/251 (15%)
Query: 347 LLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQA 406
L +LQQL++ K KL++ +EA+ +A+R EEEER+R + QQ
Sbjct: 744 LEQLQQLEKAKAAKLEQER--REAEMRAKR---EEEERKRQEELRRQQE----------- 787
Query: 407 RASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEE 466
E+ + +R+R +E E +++ +EAL+ R+ E+ + + + R EE
Sbjct: 788 --------EILRRQQEEERKRREEEELARRKQEEALR-----RQREQEIALRRQREEEER 834
Query: 467 EEKLKQLMQLKEEQERYIERAQQEK--EELQQEMAQQSRSLQQAQQQLEEVRQNRQRADE 524
+++ + L +L+E + ER +QE+ + ++E A+ +R ++AQ++LEE NR R +E
Sbjct: 835 QQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEE---NRLRMEE 891
Query: 525 DVEAAQRKLRQASTNVKHWNVQMNRLMHPIEPGDKRPVTSSSFSGFQPPLLAHRDSSLKR 584
EAA+ + + K VQ + + + + Q L L
Sbjct: 892 --EAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQL---AQMKLPS 946
Query: 585 LTRWGSQGNRT 595
+ WG Q N T
Sbjct: 947 SSTWGQQSNTT 957
Score = 38.5 bits (88), Expect = 0.019
Identities = 40/206 (19%), Positives = 83/206 (40%), Gaps = 33/206 (16%)
Query: 314 QAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQE---------- 363
Q++ SL + K + +R+ RE +R + E + LQQ Q+++++KL
Sbjct: 960 QSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGT 1019
Query: 364 ----LELLQEAQRQAERLLQEEEER------RRSQHRELQQALEGQL----------REA 403
LE+ QE RQ ++ Q++++ R + H L ++ + + A
Sbjct: 1020 TKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLHTSIGNSVWGSINTGPPNQWA 1079
Query: 404 EQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLL 463
+S+ + + K +KE+ + + V Q + +
Sbjct: 1080 SDLVSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSK---SVGVSNRQNKKV 1136
Query: 464 EEEEEKLKQLMQLKEEQERYIERAQQ 489
EEEE+ LK + + Q+ + + +Q
Sbjct: 1137 EEEEKLLKLFQGVNKAQDGFTQWCEQ 1162
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 91.7 bits (226), Expect = 2e-18
Identities = 74/228 (32%), Positives = 126/228 (55%), Gaps = 27/228 (11%)
Query: 331 EQREQRERRRAAKEEELLRLQQLQ---EEKERKLQELELLQEAQRQAERLL--QEEEERR 385
EQ +Q E+ +AAK E+ R +++ EE+ERK QE E +RQ E +L Q+EEER+
Sbjct: 724 EQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQE-----ELRRQQEEILRRQQEEERK 778
Query: 386 RSQHREL-----QQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQE 440
R + EL ++AL Q RE E A + E E +++E A +R + EE ++R QE
Sbjct: 779 RREEEELARRKQEEALRRQ-REQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQE 837
Query: 441 ALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQ 500
E+ +++EE+ + A+ EE + +L++ EE+ + ++E++ + E+ +
Sbjct: 838 ----ELLRKQEEEAAKWAREE--EEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQR 891
Query: 501 QSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMN 548
Q ++Q QQQ E +R+ +Q+ + + AQ KL +ST W Q N
Sbjct: 892 QKELMRQRQQQQEALRRLQQQQQQQ-QLAQMKLPSSST----WGQQSN 934
Score = 88.2 bits (217), Expect = 2e-17
Identities = 66/209 (31%), Positives = 115/209 (55%), Gaps = 25/209 (11%)
Query: 310 AIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQEL----- 364
A +L+ E + + +++ KR E+ +R+ ++EE+LR QQ +E K R+ +EL
Sbjct: 734 AAKLEQERREA---EMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQ 790
Query: 365 -ELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAAR 423
E L+ + Q L ++ EE R Q E + LE + RE E+ R Q E+ K+EE A
Sbjct: 791 EEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRK--QEELLRKQEEEAA 848
Query: 424 QRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERY 483
+ R E EE Q+RL+E + R +EE+ R L EEEE+ ++ ++++ ++E
Sbjct: 849 KWAR--EEEEAQRRLEEN-----RLRMEEEAAR-----LRHEEEERKRKELEVQRQKE-- 894
Query: 484 IERAQQEKEELQQEMAQQSRSLQQAQQQL 512
+ R +Q+++E + + QQ + Q AQ +L
Sbjct: 895 LMRQRQQQQEALRRLQQQQQQQQLAQMKL 923
Score = 84.0 bits (206), Expect = 4e-16
Identities = 68/263 (25%), Positives = 134/263 (50%), Gaps = 47/263 (17%)
Query: 308 QMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELL 367
++A R Q E +L + +Q+ +R++ E R +EE L RL++ + E+E + ++ ELL
Sbjct: 784 ELARRKQEE---ALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELL 840
Query: 368 QEAQRQAERLLQEEEE--RRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQR 425
++ + +A + +EEEE RR ++R + +LR E+ R + E++ +++E RQR
Sbjct: 841 RKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQ-RQKELMRQR 899
Query: 426 QRIKE-LEEMQQRLQEALQLEVK--------------ARRDEESVRIAQTRLLEEEEEKL 470
Q+ +E L +QQ+ Q+ ++K A + + ++ +A+ + LEEE E+
Sbjct: 900 QQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERER- 958
Query: 471 KQLMQLKEEQERYIERAQQEKE------------------------ELQQEMAQQSRSLQ 506
QL + + Q+R + +A Q+++ E+QQE A+Q + Q
Sbjct: 959 -QLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQ 1017
Query: 507 QAQQQLEEVRQNRQRADEDVEAA 529
Q QQQ ++ + R ++ +
Sbjct: 1018 QQQQQHQQPNRARNNTHSNLHTS 1040
Score = 66.2 bits (160), Expect = 8e-11
Identities = 66/251 (26%), Positives = 119/251 (47%), Gaps = 39/251 (15%)
Query: 347 LLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQA 406
L +LQQL++ K KL++ +EA+ +A+R EEEER+R + QQ
Sbjct: 723 LEQLQQLEKAKAAKLEQER--REAEMRAKR---EEEERKRQEELRRQQE----------- 766
Query: 407 RASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEE 466
E+ + +R+R +E E +++ +EAL+ R+ E+ + + + R EE
Sbjct: 767 --------EILRRQQEEERKRREEEELARRKQEEALR-----RQREQEIALRRQREEEER 813
Query: 467 EEKLKQLMQLKEEQERYIERAQQEK--EELQQEMAQQSRSLQQAQQQLEEVRQNRQRADE 524
+++ + L +L+E + ER +QE+ + ++E A+ +R ++AQ++LEE NR R +E
Sbjct: 814 QQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEE---NRLRMEE 870
Query: 525 DVEAAQRKLRQASTNVKHWNVQMNRLMHPIEPGDKRPVTSSSFSGFQPPLLAHRDSSLKR 584
EAA+ + + K VQ + + + + Q L L
Sbjct: 871 --EAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQL---AQMKLPS 925
Query: 585 LTRWGSQGNRT 595
+ WG Q N T
Sbjct: 926 SSTWGQQSNTT 936
Score = 38.5 bits (88), Expect = 0.019
Identities = 40/206 (19%), Positives = 83/206 (40%), Gaps = 33/206 (16%)
Query: 314 QAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQE---------- 363
Q++ SL + K + +R+ RE +R + E + LQQ Q+++++KL
Sbjct: 939 QSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGT 998
Query: 364 ----LELLQEAQRQAERLLQEEEER------RRSQHRELQQALEGQL----------REA 403
LE+ QE RQ ++ Q++++ R + H L ++ + + A
Sbjct: 999 TKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLHTSIGNSVWGSINTGPPNQWA 1058
Query: 404 EQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLL 463
+S+ + + K +KE+ + + V Q + +
Sbjct: 1059 SDLVSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSK---SVGVSNRQNKKV 1115
Query: 464 EEEEEKLKQLMQLKEEQERYIERAQQ 489
EEEE+ LK + + Q+ + + +Q
Sbjct: 1116 EEEEKLLKLFQGVNKAQDGFTQWCEQ 1141
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 91.7 bits (226), Expect = 2e-18
Identities = 74/228 (32%), Positives = 126/228 (55%), Gaps = 27/228 (11%)
Query: 331 EQREQRERRRAAKEEELLRLQQLQ---EEKERKLQELELLQEAQRQAERLL--QEEEERR 385
EQ +Q E+ +AAK E+ R +++ EE+ERK QE E +RQ E +L Q+EEER+
Sbjct: 724 EQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQE-----ELRRQQEEILRRQQEEERK 778
Query: 386 RSQHREL-----QQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQE 440
R + EL ++AL Q RE E A + E E +++E A +R + EE ++R QE
Sbjct: 779 RREEEELARRKQEEALRRQ-REQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQE 837
Query: 441 ALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQ 500
E+ +++EE+ + A+ EE + +L++ EE+ + ++E++ + E+ +
Sbjct: 838 ----ELLRKQEEEAAKWAREE--EEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQR 891
Query: 501 QSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMN 548
Q ++Q QQQ E +R+ +Q+ + + AQ KL +ST W Q N
Sbjct: 892 QKELMRQRQQQQEALRRLQQQQQQQ-QLAQMKLPSSST----WGQQSN 934
Score = 88.2 bits (217), Expect = 2e-17
Identities = 66/209 (31%), Positives = 115/209 (55%), Gaps = 25/209 (11%)
Query: 310 AIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQEL----- 364
A +L+ E + + +++ KR E+ +R+ ++EE+LR QQ +E K R+ +EL
Sbjct: 734 AAKLEQERREA---EMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQ 790
Query: 365 -ELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAAR 423
E L+ + Q L ++ EE R Q E + LE + RE E+ R Q E+ K+EE A
Sbjct: 791 EEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRK--QEELLRKQEEEAA 848
Query: 424 QRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERY 483
+ R E EE Q+RL+E + R +EE+ R L EEEE+ ++ ++++ ++E
Sbjct: 849 KWAR--EEEEAQRRLEEN-----RLRMEEEAAR-----LRHEEEERKRKELEVQRQKE-- 894
Query: 484 IERAQQEKEELQQEMAQQSRSLQQAQQQL 512
+ R +Q+++E + + QQ + Q AQ +L
Sbjct: 895 LMRQRQQQQEALRRLQQQQQQQQLAQMKL 923
Score = 84.0 bits (206), Expect = 4e-16
Identities = 68/263 (25%), Positives = 134/263 (50%), Gaps = 47/263 (17%)
Query: 308 QMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELL 367
++A R Q E +L + +Q+ +R++ E R +EE L RL++ + E+E + ++ ELL
Sbjct: 784 ELARRKQEE---ALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELL 840
Query: 368 QEAQRQAERLLQEEEE--RRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQR 425
++ + +A + +EEEE RR ++R + +LR E+ R + E++ +++E RQR
Sbjct: 841 RKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQ-RQKELMRQR 899
Query: 426 QRIKE-LEEMQQRLQEALQLEVK--------------ARRDEESVRIAQTRLLEEEEEKL 470
Q+ +E L +QQ+ Q+ ++K A + + ++ +A+ + LEEE E+
Sbjct: 900 QQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERER- 958
Query: 471 KQLMQLKEEQERYIERAQQEKE------------------------ELQQEMAQQSRSLQ 506
QL + + Q+R + +A Q+++ E+QQE A+Q + Q
Sbjct: 959 -QLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQ 1017
Query: 507 QAQQQLEEVRQNRQRADEDVEAA 529
Q QQQ ++ + R ++ +
Sbjct: 1018 QQQQQHQQPNRARNNTHSNLHTS 1040
Score = 66.2 bits (160), Expect = 8e-11
Identities = 66/251 (26%), Positives = 119/251 (47%), Gaps = 39/251 (15%)
Query: 347 LLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQA 406
L +LQQL++ K KL++ +EA+ +A+R EEEER+R + QQ
Sbjct: 723 LEQLQQLEKAKAAKLEQER--REAEMRAKR---EEEERKRQEELRRQQE----------- 766
Query: 407 RASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEE 466
E+ + +R+R +E E +++ +EAL+ R+ E+ + + + R EE
Sbjct: 767 --------EILRRQQEEERKRREEEELARRKQEEALR-----RQREQEIALRRQREEEER 813
Query: 467 EEKLKQLMQLKEEQERYIERAQQEK--EELQQEMAQQSRSLQQAQQQLEEVRQNRQRADE 524
+++ + L +L+E + ER +QE+ + ++E A+ +R ++AQ++LEE NR R +E
Sbjct: 814 QQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEE---NRLRMEE 870
Query: 525 DVEAAQRKLRQASTNVKHWNVQMNRLMHPIEPGDKRPVTSSSFSGFQPPLLAHRDSSLKR 584
EAA+ + + K VQ + + + + Q L L
Sbjct: 871 --EAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQL---AQMKLPS 925
Query: 585 LTRWGSQGNRT 595
+ WG Q N T
Sbjct: 926 SSTWGQQSNTT 936
Score = 38.5 bits (88), Expect = 0.019
Identities = 40/206 (19%), Positives = 83/206 (40%), Gaps = 33/206 (16%)
Query: 314 QAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQE---------- 363
Q++ SL + K + +R+ RE +R + E + LQQ Q+++++KL
Sbjct: 939 QSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGT 998
Query: 364 ----LELLQEAQRQAERLLQEEEER------RRSQHRELQQALEGQL----------REA 403
LE+ QE RQ ++ Q++++ R + H L ++ + + A
Sbjct: 999 TKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLHTSIGNSVWGSINTGPPNQWA 1058
Query: 404 EQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLL 463
+S+ + + K +KE+ + + V Q + +
Sbjct: 1059 SDLVSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSK---SVGVSNRQNKKV 1115
Query: 464 EEEEEKLKQLMQLKEEQERYIERAQQ 489
EEEE+ LK + + Q+ + + +Q
Sbjct: 1116 EEEEKLLKLFQGVNKAQDGFTQWCEQ 1141
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 91.7 bits (226), Expect = 2e-18
Identities = 62/239 (25%), Positives = 134/239 (56%), Gaps = 19/239 (7%)
Query: 314 QAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQ 373
+ E K +D ++ E+ ++E + +EE++ R ++ E++ K+QE E +E RQ
Sbjct: 336 EQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQE--EEMWRQ 393
Query: 374 AERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEE 433
E++ ++EE+R+ R+ E ++RE ++ ++ +EEE RQ ++I+ELEE
Sbjct: 394 EEKIREQEEKRQEKMWRQ-----EKKMREQDE-------KIREQEEEMWRQEEKIRELEE 441
Query: 434 MQQRLQEAL-QLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEK- 491
M Q +E L ++E K + +EE ++ Q ++ +EEK+++ + QE+ ++ Q+EK
Sbjct: 442 MMQDQEEKLREVEEKMQEEEEKMQ-EQEEKIQRQEEKIQEQEEKTWRQEKLLK--QEEKI 498
Query: 492 EELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRL 550
E +++M +Q + + +++++E + QR +E + + +L Q ++ V++ L
Sbjct: 499 WEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQEL 557
Score = 87.8 bits (216), Expect = 3e-17
Identities = 52/221 (23%), Positives = 129/221 (58%), Gaps = 9/221 (4%)
Query: 309 MAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQ--EEKERKLQELEL 366
++ +LQA+ + + +L +++E++ R+ + ++EE + Q+L+ E++E+ ++ E
Sbjct: 274 VSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEK 333
Query: 367 LQEAQ---RQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAAR 423
+ E + R+ E + +EE+ R Q ++++ E R+ E+ R +++ +EEE R
Sbjct: 334 MHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIR-EQDEKIQEQEEEMWR 392
Query: 424 QRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERY 483
Q ++I+E EE +Q ++ + E K R +E +R Q + +EEK+++L ++ ++QE
Sbjct: 393 QEEKIREQEEKRQ--EKMWRQEKKMREQDEKIR-EQEEEMWRQEEKIRELEEMMQDQEEK 449
Query: 484 IERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADE 524
+ +++ +E +++M +Q +Q+ +++++E + R ++
Sbjct: 450 LREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEK 490
Score = 86.7 bits (213), Expect = 6e-17
Identities = 54/223 (24%), Positives = 122/223 (54%), Gaps = 14/223 (6%)
Query: 311 IRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEA 370
IR Q E + + ++ + REQ E+ + +EE + ++++E++E++ +++ ++
Sbjct: 355 IREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKK 414
Query: 371 QRQAERLLQEEEE---RRRSQHRELQQALEGQ---LREAEQARASMQAEMELKEEEAARQ 424
R+ + ++E+EE R+ + REL++ ++ Q LRE E+ + +M+ +EE+ RQ
Sbjct: 415 MREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQ 474
Query: 425 RQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYI 484
++I+E EE R ++ L+ E K EE + + ++ E+EE+ +EQE +
Sbjct: 475 EEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKM--------QEQEEKM 526
Query: 485 ERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVE 527
+R +++ E + + QQ +Q+ + +L+E+ + + + E
Sbjct: 527 QRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAE 569
Score = 82.4 bits (202), Expect = 1e-15
Identities = 61/254 (24%), Positives = 132/254 (51%), Gaps = 15/254 (5%)
Query: 283 VKTANRTYEMSASDTRQRQEWTAAIQMAIRLQA-EGKTSLHKDLKQKRREQREQRERRRA 341
VK R E + Q+Q A ++ LQ+ K + + +Q+E +
Sbjct: 241 VKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMW 300
Query: 342 AKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLR 401
+EE++ ++ E+E K++E E ++ RQ E++ ++EE+ R + + +Q E ++R
Sbjct: 301 RQEEKIQEQEEKMCEQELKIREQE--EKMWRQEEKMHEQEEKIREQEDKMWRQ--EEKIR 356
Query: 402 EAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTR 461
E E+ + +M +EE+ Q ++I+E EE R +E ++ E + +R E+ R Q +
Sbjct: 357 EQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIR-EQEEKRQEKMWR--QEK 413
Query: 462 LLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQR 521
+ E++EK++ EQE + R +++ EL++ M Q L++ +++++E + Q
Sbjct: 414 KMREQDEKIR-------EQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQE 466
Query: 522 ADEDVEAAQRKLRQ 535
+E ++ + K+++
Sbjct: 467 QEEKIQRQEEKIQE 480
Score = 81.3 bits (199), Expect = 3e-15
Identities = 58/245 (23%), Positives = 130/245 (53%), Gaps = 16/245 (6%)
Query: 314 QAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQ 373
Q E K ++ Q++ E+ ++E + +EE++ R ++ E+E K++E E + RQ
Sbjct: 294 QQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQE--DKMWRQ 351
Query: 374 AERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEM-----ELKEEEAARQRQRI 428
E++ ++EE+ R + + +Q E ++RE ++ + EM +++E+E RQ +
Sbjct: 352 EEKIREQEEKIREQEEKMWRQ--EEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMW 409
Query: 429 KELEEMQQRLQEALQLEVKARRDEESVRIA------QTRLLEEEEEKLKQLMQLKEEQER 482
++ ++M+++ ++ + E + R EE +R Q L E EEK+++ + +EQE
Sbjct: 410 RQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEE 469
Query: 483 YIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKH 542
I+R Q+EK + Q+E + L + ++++ E + R +E + + K+++ ++
Sbjct: 470 KIQR-QEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQR 528
Query: 543 WNVQM 547
+M
Sbjct: 529 QEEKM 533
Score = 80.5 bits (197), Expect = 4e-15
Identities = 61/277 (22%), Positives = 135/277 (48%), Gaps = 26/277 (9%)
Query: 301 QEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERK 360
+E A +Q +RL K+ + ++K +R + + + LL QQLQ E +R
Sbjct: 217 KEKNAELQEKLRLVESEKSEIQLNVKDLKR---------KLERAQLLLPQQQLQVEADRL 267
Query: 361 LQELELLQ-EAQRQAER-----LLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEM 414
+EL+ + + Q Q E LL +++E + + E Q E ++ E E + +M
Sbjct: 268 GKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKM 327
Query: 415 ELKEEEAARQRQRIKELEEMQQRLQEAL--------QLEVKARRDEESVRIAQTRLLEEE 466
+EE+ Q ++I+E E+ R +E + + E K R EE +R ++ E+E
Sbjct: 328 WRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQE 387
Query: 467 EEKLKQLMQLKEEQERYIE---RAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRAD 523
EE +Q +++E++E+ E R +++ E +++ +Q + + ++++ E+ + Q +
Sbjct: 388 EEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQE 447
Query: 524 EDVEAAQRKLRQASTNVKHWNVQMNRLMHPIEPGDKR 560
E + + K+++ ++ ++ R I+ +++
Sbjct: 448 EKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEK 484
Score = 77.4 bits (189), Expect = 4e-14
Identities = 64/247 (25%), Positives = 129/247 (52%), Gaps = 32/247 (12%)
Query: 326 KQKRREQREQRERRRAAKEEELLRLQQ----LQEEKERKLQELELLQEAQ-RQAERLLQE 380
++++R+++ R+ ++ +++E +R Q+ QEEK R+L+E+ QE + R+ E +QE
Sbjct: 400 QEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQE 459
Query: 381 EEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEA--ARQRQRIKELEEMQQRL 438
EEE+ + Q ++Q+ E + EQ + + E LK+EE ++ + ++ E+M ++
Sbjct: 460 EEEKMQEQEEKIQRQEE---KIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQE 516
Query: 439 QEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEK------- 491
++ + E K +R EE +R + RL ++EE+ +Q ++L+E +ER + Q+ +
Sbjct: 517 EKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGGAGR 576
Query: 492 -----------EELQQEM-AQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQAST- 538
LQ E+ +Q+++SLQQ Q Q A + + + + L S+
Sbjct: 577 ESGSQRLPTLTPILQVELKSQEAQSLQQQQDHYRGHLQQYVAAYQQLASGKEALPSCSSR 636
Query: 539 --NVKHW 543
K W
Sbjct: 637 KLRAKRW 643
Score = 55.8 bits (133), Expect = 1e-07
Identities = 54/227 (23%), Positives = 108/227 (47%), Gaps = 35/227 (15%)
Query: 313 LQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQR 372
L+ T ++LK+K E +E+ + K E L ++ L+ RKL+ +LL Q+
Sbjct: 204 LELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLK----RKLERAQLLLPQQQ 259
Query: 373 QAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELE 432
LQ E +R + + + L+ Q+ E E Q + EE+ RQ ++I+E E
Sbjct: 260 -----LQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQ----EEKMWRQEEKIQEQE 310
Query: 433 EMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKE----EQERYIERAQ 488
E + + E+K R EE + +EEK+ + +E EQE + R +
Sbjct: 311 E------KMCEQELKIREQEEK--------MWRQEEKMHE----QEEKIREQEDKMWRQE 352
Query: 489 QEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQ 535
++ E ++++ +Q + + ++++ E + Q +E++ + K+R+
Sbjct: 353 EKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIRE 399
Score = 42.4 bits (98), Expect = 0.001
Identities = 40/206 (19%), Positives = 90/206 (43%), Gaps = 39/206 (18%)
Query: 291 EMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRL 350
+M + + +++ + ++Q + + + ++ K+ E+ ++E + +EE++
Sbjct: 456 KMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQ 515
Query: 351 QQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASM 410
++ +E+E K+Q E ++ + Q RL Q+EE
Sbjct: 516 EEKMQEQEEKMQRQE--EKMREQEVRLWQQEE---------------------------- 545
Query: 411 QAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKL 470
+++E+E R++ELEE +L + +L A R+ S R+ + + E K
Sbjct: 546 ----KMQEQEV-----RLQELEERLGKLGQKAELLGGAGRESGSQRLPTLTPILQVELKS 596
Query: 471 KQLMQLKEEQERYIERAQQEKEELQQ 496
++ L+++Q+ Y QQ QQ
Sbjct: 597 QEAQSLQQQQDHYRGHLQQYVAAYQQ 622
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 91.7 bits (226), Expect = 2e-18
Identities = 62/239 (25%), Positives = 134/239 (56%), Gaps = 19/239 (7%)
Query: 314 QAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQ 373
+ E K +D ++ E+ ++E + +EE++ R ++ E++ K+QE E +E RQ
Sbjct: 336 EQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQE--EEMWRQ 393
Query: 374 AERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEE 433
E++ ++EE+R+ R+ E ++RE ++ ++ +EEE RQ ++I+ELEE
Sbjct: 394 EEKIREQEEKRQEKMWRQ-----EKKMREQDE-------KIREQEEEMWRQEEKIRELEE 441
Query: 434 MQQRLQEAL-QLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEK- 491
M Q +E L ++E K + +EE ++ Q ++ +EEK+++ + QE+ ++ Q+EK
Sbjct: 442 MMQDQEEKLREVEEKMQEEEEKMQ-EQEEKIQRQEEKIQEQEEKTWRQEKLLK--QEEKI 498
Query: 492 EELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRL 550
E +++M +Q + + +++++E + QR +E + + +L Q ++ V++ L
Sbjct: 499 WEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQEL 557
Score = 87.8 bits (216), Expect = 3e-17
Identities = 52/221 (23%), Positives = 129/221 (58%), Gaps = 9/221 (4%)
Query: 309 MAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQ--EEKERKLQELEL 366
++ +LQA+ + + +L +++E++ R+ + ++EE + Q+L+ E++E+ ++ E
Sbjct: 274 VSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEK 333
Query: 367 LQEAQ---RQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAAR 423
+ E + R+ E + +EE+ R Q ++++ E R+ E+ R +++ +EEE R
Sbjct: 334 MHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIR-EQDEKIQEQEEEMWR 392
Query: 424 QRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERY 483
Q ++I+E EE +Q ++ + E K R +E +R Q + +EEK+++L ++ ++QE
Sbjct: 393 QEEKIREQEEKRQ--EKMWRQEKKMREQDEKIR-EQEEEMWRQEEKIRELEEMMQDQEEK 449
Query: 484 IERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADE 524
+ +++ +E +++M +Q +Q+ +++++E + R ++
Sbjct: 450 LREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEK 490
Score = 86.7 bits (213), Expect = 6e-17
Identities = 54/223 (24%), Positives = 122/223 (54%), Gaps = 14/223 (6%)
Query: 311 IRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEA 370
IR Q E + + ++ + REQ E+ + +EE + ++++E++E++ +++ ++
Sbjct: 355 IREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKK 414
Query: 371 QRQAERLLQEEEE---RRRSQHRELQQALEGQ---LREAEQARASMQAEMELKEEEAARQ 424
R+ + ++E+EE R+ + REL++ ++ Q LRE E+ + +M+ +EE+ RQ
Sbjct: 415 MREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQ 474
Query: 425 RQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYI 484
++I+E EE R ++ L+ E K EE + + ++ E+EE+ +EQE +
Sbjct: 475 EEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKM--------QEQEEKM 526
Query: 485 ERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVE 527
+R +++ E + + QQ +Q+ + +L+E+ + + + E
Sbjct: 527 QRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAE 569
Score = 82.4 bits (202), Expect = 1e-15
Identities = 61/254 (24%), Positives = 132/254 (51%), Gaps = 15/254 (5%)
Query: 283 VKTANRTYEMSASDTRQRQEWTAAIQMAIRLQA-EGKTSLHKDLKQKRREQREQRERRRA 341
VK R E + Q+Q A ++ LQ+ K + + +Q+E +
Sbjct: 241 VKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMW 300
Query: 342 AKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLR 401
+EE++ ++ E+E K++E E ++ RQ E++ ++EE+ R + + +Q E ++R
Sbjct: 301 RQEEKIQEQEEKMCEQELKIREQE--EKMWRQEEKMHEQEEKIREQEDKMWRQ--EEKIR 356
Query: 402 EAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTR 461
E E+ + +M +EE+ Q ++I+E EE R +E ++ E + +R E+ R Q +
Sbjct: 357 EQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIR-EQEEKRQEKMWR--QEK 413
Query: 462 LLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQR 521
+ E++EK++ EQE + R +++ EL++ M Q L++ +++++E + Q
Sbjct: 414 KMREQDEKIR-------EQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQE 466
Query: 522 ADEDVEAAQRKLRQ 535
+E ++ + K+++
Sbjct: 467 QEEKIQRQEEKIQE 480
Score = 81.3 bits (199), Expect = 3e-15
Identities = 58/245 (23%), Positives = 130/245 (53%), Gaps = 16/245 (6%)
Query: 314 QAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQ 373
Q E K ++ Q++ E+ ++E + +EE++ R ++ E+E K++E E + RQ
Sbjct: 294 QQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQE--DKMWRQ 351
Query: 374 AERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEM-----ELKEEEAARQRQRI 428
E++ ++EE+ R + + +Q E ++RE ++ + EM +++E+E RQ +
Sbjct: 352 EEKIREQEEKIREQEEKMWRQ--EEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMW 409
Query: 429 KELEEMQQRLQEALQLEVKARRDEESVRIA------QTRLLEEEEEKLKQLMQLKEEQER 482
++ ++M+++ ++ + E + R EE +R Q L E EEK+++ + +EQE
Sbjct: 410 RQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEE 469
Query: 483 YIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKH 542
I+R Q+EK + Q+E + L + ++++ E + R +E + + K+++ ++
Sbjct: 470 KIQR-QEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQR 528
Query: 543 WNVQM 547
+M
Sbjct: 529 QEEKM 533
Score = 80.5 bits (197), Expect = 4e-15
Identities = 61/277 (22%), Positives = 135/277 (48%), Gaps = 26/277 (9%)
Query: 301 QEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERK 360
+E A +Q +RL K+ + ++K +R + + + LL QQLQ E +R
Sbjct: 217 KEKNAELQEKLRLVESEKSEIQLNVKDLKR---------KLERAQLLLPQQQLQVEADRL 267
Query: 361 LQELELLQ-EAQRQAER-----LLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEM 414
+EL+ + + Q Q E LL +++E + + E Q E ++ E E + +M
Sbjct: 268 GKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKM 327
Query: 415 ELKEEEAARQRQRIKELEEMQQRLQEAL--------QLEVKARRDEESVRIAQTRLLEEE 466
+EE+ Q ++I+E E+ R +E + + E K R EE +R ++ E+E
Sbjct: 328 WRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQE 387
Query: 467 EEKLKQLMQLKEEQERYIE---RAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRAD 523
EE +Q +++E++E+ E R +++ E +++ +Q + + ++++ E+ + Q +
Sbjct: 388 EEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQE 447
Query: 524 EDVEAAQRKLRQASTNVKHWNVQMNRLMHPIEPGDKR 560
E + + K+++ ++ ++ R I+ +++
Sbjct: 448 EKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEK 484
Score = 77.4 bits (189), Expect = 4e-14
Identities = 64/247 (25%), Positives = 129/247 (52%), Gaps = 32/247 (12%)
Query: 326 KQKRREQREQRERRRAAKEEELLRLQQ----LQEEKERKLQELELLQEAQ-RQAERLLQE 380
++++R+++ R+ ++ +++E +R Q+ QEEK R+L+E+ QE + R+ E +QE
Sbjct: 400 QEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQE 459
Query: 381 EEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEA--ARQRQRIKELEEMQQRL 438
EEE+ + Q ++Q+ E + EQ + + E LK+EE ++ + ++ E+M ++
Sbjct: 460 EEEKMQEQEEKIQRQEE---KIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQE 516
Query: 439 QEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEK------- 491
++ + E K +R EE +R + RL ++EE+ +Q ++L+E +ER + Q+ +
Sbjct: 517 EKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGGAGR 576
Query: 492 -----------EELQQEM-AQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQAST- 538
LQ E+ +Q+++SLQQ Q Q A + + + + L S+
Sbjct: 577 ESGSQRLPTLTPILQVELKSQEAQSLQQQQDHYRGHLQQYVAAYQQLASGKEALPSCSSR 636
Query: 539 --NVKHW 543
K W
Sbjct: 637 KLRAKRW 643
Score = 57.8 bits (138), Expect = 3e-08
Identities = 55/230 (23%), Positives = 110/230 (47%), Gaps = 35/230 (15%)
Query: 310 AIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQE 369
A+ L+ T ++LK+K E +E+ + K E L ++ L+ RKL+ +LL
Sbjct: 201 ALSLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLK----RKLERAQLLLP 256
Query: 370 AQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIK 429
Q+ LQ E +R + + + L+ Q+ E E Q + EE+ RQ ++I+
Sbjct: 257 QQQ-----LQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQ----EEKMWRQEEKIQ 307
Query: 430 ELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKE----EQERYIE 485
E EE + + E+K R EE + +EEK+ + +E EQE +
Sbjct: 308 EQEE------KMCEQELKIREQEEK--------MWRQEEKMHE----QEEKIREQEDKMW 349
Query: 486 RAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQ 535
R +++ E ++++ +Q + + ++++ E + Q +E++ + K+R+
Sbjct: 350 RQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIRE 399
Score = 42.4 bits (98), Expect = 0.001
Identities = 40/206 (19%), Positives = 90/206 (43%), Gaps = 39/206 (18%)
Query: 291 EMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRL 350
+M + + +++ + ++Q + + + ++ K+ E+ ++E + +EE++
Sbjct: 456 KMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQ 515
Query: 351 QQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASM 410
++ +E+E K+Q E ++ + Q RL Q+EE
Sbjct: 516 EEKMQEQEEKMQRQE--EKMREQEVRLWQQEE---------------------------- 545
Query: 411 QAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKL 470
+++E+E R++ELEE +L + +L A R+ S R+ + + E K
Sbjct: 546 ----KMQEQEV-----RLQELEERLGKLGQKAELLGGAGRESGSQRLPTLTPILQVELKS 596
Query: 471 KQLMQLKEEQERYIERAQQEKEELQQ 496
++ L+++Q+ Y QQ QQ
Sbjct: 597 QEAQSLQQQQDHYRGHLQQYVAAYQQ 622
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 91.3 bits (225), Expect = 2e-18
Identities = 63/236 (26%), Positives = 131/236 (55%), Gaps = 22/236 (9%)
Query: 320 SLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQ 379
+L +++ ++ E REQ ++ R +EE++ R ++ E+E K++E E E + E+ L+
Sbjct: 269 TLQEEMWRQEEELREQEKKIRK-QEEKMWRQEERLREQEGKMREQE---EKMWRQEKRLR 324
Query: 380 EEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQ 439
E+E+ R Q +EL++ + +LRE E+ +M+ +EE+ Q ++++E EE R +
Sbjct: 325 EQEKELREQEKELRE--QKELREQEE-------QMQEQEEKMWEQEEKMREQEEKMWRQE 375
Query: 440 EALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQ-QEM 498
E L + K R++E Q + E++E+L++ + EQE+ E+ ++ +EE + QE
Sbjct: 376 ERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQ 435
Query: 499 AQQSRSLQQAQQQLEEVRQNRQRADEDVEA---AQRKLRQASTNV-----KHWNVQ 546
+++R ++ Q+ E +R+ ++ E+ E + K+++ N+ K W Q
Sbjct: 436 EKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQ 491
Score = 89.0 bits (219), Expect = 1e-17
Identities = 65/269 (24%), Positives = 140/269 (52%), Gaps = 30/269 (11%)
Query: 310 AIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKER------KLQE 363
A+ L+ T +++LK+K E +E+ + K E L +++L+ + ER ++Q
Sbjct: 208 ALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQT 267
Query: 364 LELLQEAQRQAERLLQEEEERRRSQHRELQQA-----LEGQLREAE-----QARASMQAE 413
L +E RQ E L ++E++ R+ + + +Q EG++RE E Q + + E
Sbjct: 268 NTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQE 327
Query: 414 MELKEEE-AARQRQRIKELEEMQQRLQEAL-QLEVKARRDEESVRIAQTRLLEEEEEKLK 471
EL+E+E R+++ ++E EE Q +E + + E K R EE + + RL E+E++ +
Sbjct: 328 KELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMRE 387
Query: 472 QLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQ----------- 520
Q ++++++ER E+ ++ +E+ ++ M +Q + +Q ++ EE + Q
Sbjct: 388 QEQKMRDQEERMWEQDERLREK-EERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKM 446
Query: 521 RADEDVEAAQRKLRQASTNVKHWNVQMNR 549
+ +E + ++K+R+ ++ +M +
Sbjct: 447 QEEERIREREKKMREEEETMREQEEKMQK 475
Score = 84.0 bits (206), Expect = 4e-16
Identities = 65/260 (25%), Positives = 137/260 (52%), Gaps = 23/260 (8%)
Query: 291 EMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRL 350
E+ + + R++ + RL+ + ++ K R+E+R + + + ++E+ LR
Sbjct: 280 ELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELRE 339
Query: 351 QQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASM 410
Q+ E+E ++QE E ++ Q E++ ++EE+ R + R +Q E Q+RE EQ
Sbjct: 340 QKELREQEEQMQEQE--EKMWEQEEKMREQEEKMWRQEERLWEQ--EKQMREQEQKMRDQ 395
Query: 411 QAEMELKEEEAARQRQRIKELEEM-----QQRLQEALQLEVKARRD-------EESVRIA 458
+ M ++E + +R++E E+M + R ++ +Q + K RD EE +R
Sbjct: 396 EERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIRER 455
Query: 459 QTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSL---QQAQQQLEEV 515
+ ++ EEEE +Q ++++++E E Q+EKE QQ + +Q L ++ Q+Q E++
Sbjct: 456 EKKMREEEETMREQEEKMQKQEENMWE--QEEKEWQQQRLPEQKEKLWEQEKMQEQEEKI 513
Query: 516 --RQNRQRADEDVEAAQRKL 533
++ + R E++ ++K+
Sbjct: 514 WEQEEKIRDQEEMWGQEKKM 533
Score = 80.9 bits (198), Expect = 3e-15
Identities = 67/261 (25%), Positives = 131/261 (50%), Gaps = 25/261 (9%)
Query: 295 SDTRQRQEWTAAIQMA-----IRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLR 349
++T Q + W ++ IR Q E + L+++ + REQ E+ ++E+ LR
Sbjct: 267 TNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMW--RQEKRLR 324
Query: 350 LQQLQEEKERKLQELELLQEAQ-RQAERLLQEEEERRRSQHRELQQ------ALEGQLRE 402
++EKE + QE EL ++ + R+ E +QE+EE+ Q ++++ E +L E
Sbjct: 325 ----EQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWE 380
Query: 403 AEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRL 462
E+ + +M +EE Q +R++E EE + R QE + +V+ R+E+ ++ Q +
Sbjct: 381 QEKQMREQEQKMRDQEERMWEQDERLREKEE-RMREQEKMWEQVEKMREEKKMQ-EQEKK 438
Query: 463 LEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRA 522
++EEK+++ EE+ R E+ +E+EE +E ++ + ++ + EE +QR
Sbjct: 439 TRDQEEKMQE-----EERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRL 493
Query: 523 DEDVEAAQRKLRQASTNVKHW 543
E E + + K W
Sbjct: 494 PEQKEKLWEQEKMQEQEEKIW 514
Score = 80.9 bits (198), Expect = 3e-15
Identities = 55/266 (20%), Positives = 137/266 (51%), Gaps = 21/266 (7%)
Query: 291 EMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRL 350
+M + + R++ + RL + K ++ K + +E+R + R ++EE +R
Sbjct: 356 KMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMRE 415
Query: 351 QQLQEEKERKLQELELLQEAQ---RQAERLLQEEEE--RRRSQHRELQQALEGQLREAEQ 405
Q+ E+ K++E + +QE + R E +QEEE R + RE ++ + Q + ++
Sbjct: 416 QEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQK 475
Query: 406 ARASM--QAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDE----------- 452
+M Q E E +++ Q++++ E E+MQ++ ++ + E K R E
Sbjct: 476 QEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWR 535
Query: 453 -ESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEEL--QQEMAQQSRSLQQAQ 509
E +R + ++ E+EE+ Q ++ +++ER ++ Q+++++ Q+E ++ +++ +
Sbjct: 536 QEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMRERE 595
Query: 510 QQLEEVRQNRQRADEDVEAAQRKLRQ 535
+++ E + + +E ++ + K+++
Sbjct: 596 KKMREEEEMMREQEEKMQEQEEKMQE 621
Score = 80.1 bits (196), Expect = 6e-15
Identities = 56/272 (20%), Positives = 132/272 (48%), Gaps = 39/272 (14%)
Query: 298 RQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEK 357
++++ W +M + Q + K + ++ K + E+ +RE++ +EE + ++ +E+
Sbjct: 556 QEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQ 615
Query: 358 ERKLQELELL-----QEAQRQAERLLQEEE-----------------------ERRRSQH 389
E K+QE E ++ Q Q E++ ++EE E + Q
Sbjct: 616 EEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQE 675
Query: 390 RELQQALEGQLREAEQARASMQAEME-------LKEEEAARQRQR-IKELEEMQQRLQEA 441
+E Q E ++ E E+ Q + + ++EEE+ R+R++ ++E EEM + +E
Sbjct: 676 QEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEK 735
Query: 442 LQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQ 501
+Q + + +++E Q + E+EEK+ + +L E++E+ E EK + Q+++ +Q
Sbjct: 736 MQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWE---HEKMQEQEKIWEQ 792
Query: 502 SRSLQQAQQQLEEVRQNRQRADEDVEAAQRKL 533
++ ++++ + + +E + + K+
Sbjct: 793 EEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKM 824
Score = 79.7 bits (195), Expect = 7e-15
Identities = 64/250 (25%), Positives = 128/250 (51%), Gaps = 20/250 (8%)
Query: 299 QRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKE 358
+ QE Q +R Q E + + ++ + REQ E + +EE L ++ E+E
Sbjct: 331 REQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQ-EEKMWRQEERLWEQEKQMREQE 389
Query: 359 RKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQA--LEGQLREAEQARASMQAEMEL 416
+K+++ E E + + L+E+EER R Q + +Q + + + EQ + + E ++
Sbjct: 390 QKMRDQE---ERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKM 446
Query: 417 KEEEAARQRQ-RIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQ 475
+EEE R+R+ +++E EE + +E +Q + + ++E Q R L E++EKL + +
Sbjct: 447 QEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQR-LPEQKEKLWEQEK 505
Query: 476 LKEEQERYIERAQQEKEELQQEMAQQSRSL----------QQAQQQLEEVRQNRQRADED 525
++E++E+ E Q+EK Q+EM Q + + Q +Q E++R Q+ +
Sbjct: 506 MQEQEEKIWE--QEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQ 563
Query: 526 VEAAQRKLRQ 535
E ++K ++
Sbjct: 564 EERMEKKTQE 573
Score = 79.3 bits (194), Expect = 1e-14
Identities = 57/271 (21%), Positives = 133/271 (49%), Gaps = 17/271 (6%)
Query: 299 QRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKE 358
Q + W +M + + + +D ++K +E+ RER + +EEE + QEEK
Sbjct: 416 QEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEE--ETMREQEEKM 473
Query: 359 RKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQ-----ALEGQLREAE-----QARA 408
+K +E QE + ++ L E++E+ Q + +Q E ++R+ E + +
Sbjct: 474 QKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKM 533
Query: 409 SMQAEMELKEEEAARQRQRIKELE----EMQQRLQEALQLEVKARRDEESVRIAQTRLLE 464
Q +M +E++ Q +++++ E + ++R+++ Q + K D+E ++ + +
Sbjct: 534 WRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEE-KMREEERMR 592
Query: 465 EEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADE 524
E E+K+++ ++ EQE ++ +++ +E +++M +Q +Q+ ++++ E + +E
Sbjct: 593 EREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEE 652
Query: 525 DVEAAQRKLRQASTNVKHWNVQMNRLMHPIE 555
+ QR Q +H +Q M E
Sbjct: 653 KMWEQQRLPEQKEKLWEHEKMQEQEKMQEQE 683
Score = 79.0 bits (193), Expect = 1e-14
Identities = 66/254 (25%), Positives = 134/254 (52%), Gaps = 20/254 (7%)
Query: 323 KDLKQKRREQREQRERRRAAKEEELLRLQQL---QEEKERKLQELELLQEAQR-QAERLL 378
K+L+++ +E REQ+E R +EE++ ++ QEEK R+ +E QE + + E+ +
Sbjct: 328 KELREQEKELREQKELRE--QEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQM 385
Query: 379 QEEEERRRSQHREL----QQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEM 434
+E+E++ R Q + ++ E + R EQ + Q E +E++ Q ++ ++ EE
Sbjct: 386 REQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEK 445
Query: 435 QQRLQEALQLEVKARRDEESVRIAQTRL------LEEEEEKLKQLMQLKEEQERYIERAQ 488
Q + + E K R +EE++R + ++ + E+EEK Q +L E++E+ E+ +
Sbjct: 446 MQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEK 505
Query: 489 -QEKEELQQEMAQQSRSLQQAQQQLEEV-RQNRQRADEDVEAAQRKLRQASTNVKHWNVQ 546
QE+EE E ++ R ++ Q +++ RQ + R ED + +++ + K W+ Q
Sbjct: 506 MQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQED-QMWEQEEKMRDQEQKMWD-Q 563
Query: 547 MNRLMHPIEPGDKR 560
R+ + +K+
Sbjct: 564 EERMEKKTQEQEKK 577
Score = 79.0 bits (193), Expect = 1e-14
Identities = 55/236 (23%), Positives = 124/236 (52%), Gaps = 18/236 (7%)
Query: 326 KQKRREQREQ----------RERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAE 375
++K REQ +Q +E++ +EE + + Q QE+K +E +E R+ E
Sbjct: 536 QEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMRERE 595
Query: 376 RLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEM- 434
+ ++EEEE R Q ++Q+ E +++E E+ + +M+ +EE+ Q +++ E EE
Sbjct: 596 KKMREEEEMMREQEEKMQEQ-EEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKM 654
Query: 435 --QQRLQEALQ--LEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQE 490
QQRL E + E + +++E ++ + ++ E+E+ + K Q K+ ++ R ++
Sbjct: 655 WEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEES 714
Query: 491 KEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQ 546
E +++M ++ +++ +++++E + Q +E++ + K+ + K W Q
Sbjct: 715 MREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEE--KMWEQQ 768
Score = 78.2 bits (191), Expect = 2e-14
Identities = 56/229 (24%), Positives = 121/229 (52%), Gaps = 31/229 (13%)
Query: 323 KDLKQKRREQREQRERRRAAKE------EELLRLQQLQEEKERKLQELELL----QEAQR 372
+D +QK +Q E+ E++ +E EE +R ++ E+E+K++E E + +E +
Sbjct: 554 RDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQ 613
Query: 373 QAERLLQEEEERRRSQHRELQQALEGQLREA-----------EQARASMQAEMELKEEEA 421
+ E +QE+EE+ Q ++Q+ E + EQ R Q E +L E E
Sbjct: 614 EQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKE-KLWEHEK 672
Query: 422 ARQRQRIKELEEM---QQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKE 478
+++++++E EE Q+++++ Q + K D+E +R + + E E+K+++ ++
Sbjct: 673 MQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMR--EEESMREREKKMREEEEMMR 730
Query: 479 EQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVE 527
EQE ++ +++ +E ++EM +Q + + ++++ E +QR E E
Sbjct: 731 EQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWE----QQRLPEQKE 775
Score = 76.6 bits (187), Expect = 6e-14
Identities = 44/219 (20%), Positives = 121/219 (55%), Gaps = 15/219 (6%)
Query: 330 REQREQRERRRAAKEEELLRLQQLQEEKERKL-QELELLQEAQRQAERLLQEEEERRRSQ 388
+E++ R+ + +E+++ ++ ++E+K+ + E +++ ++ E+ ++EE+ R +
Sbjct: 529 QEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREE 588
Query: 389 HRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKA 448
R ++ E ++RE E+ + +M+ +EE+ Q +++ E EE Q +E + + +
Sbjct: 589 ERMRER--EKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEK 646
Query: 449 RRDEESVRIAQTRLLEEEE-----EKLKQLMQLKEEQERYIER-------AQQEKEELQQ 496
++E Q RL E++E EK+++ +++E++E+ E+ +QEK+ Q
Sbjct: 647 MWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQ 706
Query: 497 EMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQ 535
E ++ S+++ ++++ E + + +E ++ + K+++
Sbjct: 707 EKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQE 745
Score = 73.6 bits (179), Expect = 5e-13
Identities = 62/292 (21%), Positives = 151/292 (51%), Gaps = 23/292 (7%)
Query: 284 KTANRTYEMSASDT-RQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAA 342
KT ++ +M + R+R++ + +R Q E +++ ++ E++E +++R
Sbjct: 438 KTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQ--EEKEWQQQRLPE 495
Query: 343 KEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQAL---EGQ 399
++E+L +++QE++E+ ++ E +++ Q E QE++ R+ + RE + + E +
Sbjct: 496 QKEKLWEQEKMQEQEEKIWEQEEKIRD---QEEMWGQEKKMWRQEKMREQEDQMWEQEEK 552
Query: 400 LREAEQARASMQAEMELK----------EEEAARQRQRIKELEEMQQRLQEAL-QLEVKA 448
+R+ EQ + ME K +EE R+ +R++E E+ + +E + + E K
Sbjct: 553 MRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKM 612
Query: 449 RRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQA 508
+ EE ++ + ++ E+EE+ +Q ++ E++E+ E Q+EK QQ + +Q L +
Sbjct: 613 QEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWE--QEEKMWEQQRLPEQKEKLWE- 669
Query: 509 QQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRLMHPIEPGDKR 560
++++E + +++ ++ E + + + K W+ + R + +K+
Sbjct: 670 HEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKK 721
Score = 70.5 bits (171), Expect = 5e-12
Identities = 55/206 (26%), Positives = 112/206 (54%), Gaps = 16/206 (7%)
Query: 326 KQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERR 385
+Q++ E++ Q E+ + ++E +R ++ E+E+K++E E E R+ E +QE+EE+
Sbjct: 688 EQEKMEKKTQ-EQEKKTWDQEKMREEESMREREKKMREEE---EMMREQEEKMQEQEEKM 743
Query: 386 RSQHREL----QQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEA 441
+ Q E+ ++ E + + EQ R Q E +L E E +++++I E EE + +E
Sbjct: 744 QEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKE-KLWEHEKMQEQEKIWEQEEKMRDQEEK 802
Query: 442 LQ-LEVKARRDEESVRIAQTRLLEEEEEKLKQLMQL--KEE----QERYIERAQQEKEEL 494
++ E K R EE +R + ++ +EE+ Q ++ +EE QE +E Q +EE
Sbjct: 803 MRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEK 862
Query: 495 QQEMAQQSRSLQQAQQQLEEVRQNRQ 520
+E ++ R ++ ++ EE + ++
Sbjct: 863 MREQEEKMRGQEEKMREQEEKMRGQE 888
Score = 66.6 bits (161), Expect = 7e-11
Identities = 55/268 (20%), Positives = 132/268 (49%), Gaps = 24/268 (8%)
Query: 291 EMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRL 350
+M + + +++ + ++Q + + ++ K +E++ ++R ++E+L
Sbjct: 611 KMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEH 670
Query: 351 QQLQEEKERKLQELELLQE------AQRQAERLLQEEEERRRSQHRELQQAL---EGQLR 401
+++QE+++ + QE ++ ++ Q Q ++ +E+ R RE ++ + E +R
Sbjct: 671 EKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMR 730
Query: 402 EAEQARASMQAEMELKEEEAARQRQRIKELEEM---QQRLQEALQLEVKARRDEESVRIA 458
E E+ + +M+ +EEE Q +++ E EE QQRL E K + E
Sbjct: 731 EQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQ-----KEKLWEHEKMQE 785
Query: 459 QTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQE--MAQQSRSLQQAQQ---QLE 513
Q ++ E+EE+ Q +++ ++E+ R Q+EK Q+E Q+ + Q ++ Q E
Sbjct: 786 QEKIWEQEEKMRDQEEKMRGQEEKM--RGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEE 843
Query: 514 EVRQNRQRADEDVEAAQRKLRQASTNVK 541
++ ++ +E ++ + K+R+ ++
Sbjct: 844 KMWGQEEKMEEKMQGQEEKMREQEEKMR 871
Score = 66.2 bits (160), Expect = 8e-11
Identities = 49/238 (20%), Positives = 122/238 (51%), Gaps = 21/238 (8%)
Query: 312 RLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQ 371
RL + + + Q++ + +EQ E+ E+E + + ++EK+ QE +E+
Sbjct: 659 RLPEQKEKLWEHEKMQEQEKMQEQEEK---IWEQEKMEKKTQEQEKKTWDQEKMREEESM 715
Query: 372 RQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEE------AARQR 425
R+ E+ ++EEEE R Q ++Q+ E +++E E+ + +M +EE+ Q+
Sbjct: 716 REREKKMREEEEMMREQEEKMQEQ-EEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQK 774
Query: 426 QRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQER--- 482
+++ E E+MQ++ ++ + E K R EE +R + ++ +EE+ Q ++ ++E+
Sbjct: 775 EKLWEHEKMQEQ-EKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWG 833
Query: 483 -------YIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKL 533
E+ ++E+++++M Q +++ ++++ + + +E + + K+
Sbjct: 834 QEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKI 891
Score = 61.2 bits (147), Expect = 3e-09
Identities = 48/190 (25%), Positives = 100/190 (52%), Gaps = 8/190 (4%)
Query: 284 KTANRTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAK 343
KT ++ R+R++ + +R Q E K ++ Q++ E+ ++E + +
Sbjct: 702 KTWDQEKMREEESMREREKKMREEEEMMREQEE-KMQEQEEKMQEQEEEMWEQEEKMWEQ 760
Query: 344 EEELLRLQQLQEEKERKLQELELLQEAQR--QAERLLQEEEERRRSQHRELQQALEGQLR 401
EE++ Q+L E+KE KL E E +QE ++ + E ++++EE+ R Q E + E ++R
Sbjct: 761 EEKMWEQQRLPEQKE-KLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQ-EEKMRGQEEKMR 818
Query: 402 EAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTR 461
E+ + +M +EE+ Q +++ EE +++E +Q + + R++E Q
Sbjct: 819 GQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEE---KMEEKMQGQEEKMREQEEKMRGQEE 875
Query: 462 LLEEEEEKLK 471
+ E+EEK++
Sbjct: 876 KMREQEEKMR 885
Score = 39.3 bits (90), Expect = 0.011
Identities = 37/178 (20%), Positives = 81/178 (45%), Gaps = 24/178 (13%)
Query: 364 LELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAAR 423
L + ++A+R ++E + R + EL + E ++ A +Q ++ L E E +
Sbjct: 185 LSAVSTRHKKADRYIEELTKERDALSLELYRNTITN-EELKKKNAELQEKLPLAESEKSE 243
Query: 424 QRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERY 483
+ +KEL+ +R + L QT L+EE M +EE+ R
Sbjct: 244 IQLNVKELKRKLERAKFLLPQ-------------VQTNTLQEE-------MWRQEEELRE 283
Query: 484 IERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVK 541
E+ +++EE +M +Q L++ + ++ E + R ++ + +++LR+ ++
Sbjct: 284 QEKKIRKQEE---KMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELR 338
>gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]
Length = 523
Score = 90.9 bits (224), Expect = 3e-18
Identities = 78/251 (31%), Positives = 130/251 (51%), Gaps = 21/251 (8%)
Query: 312 RLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQ---------LQEEKERKLQ 362
+LQAE + + L +R+E+R + + R ++EE LR Q+ L+E++ER +
Sbjct: 179 QLQAEVENNQMLSLLNRRQEERLREQEERLREQEERLREQEERLCEQEERLREQEERLRE 238
Query: 363 ELELL---QEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEE 419
+ E L +E R+ E L E+EER Q L++ E +L E E+ + + +EE
Sbjct: 239 QEERLCEQEERLREHEERLCEQEERLCEQEERLREQ-EERLHEQEERLCEQEERLREQEE 297
Query: 420 EAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEE 479
Q +R++E EE +E L+ E + R E+ Q RLLEE E+ L+Q + +EE
Sbjct: 298 RLCEQEERLREQEERLCEQEERLR-EQEERLCEQEKLPGQERLLEEVEKLLEQERR-QEE 355
Query: 480 QERYIERAQ--QEKEEL--QQEMAQQSRSL--QQAQQQLEEVRQNRQRADEDVEAAQRKL 533
QER +ER + +E EEL Q+ + QQ L Q+ Q+LE +R+ + + EA +
Sbjct: 356 QERLLERERLLEEVEELLEQERLRQQDERLWQQETLQELERLRELERMLELGWEALYEQR 415
Query: 534 RQASTNVKHWN 544
+ + + N
Sbjct: 416 AEPRSGFEELN 426
Score = 84.7 bits (208), Expect = 2e-16
Identities = 67/219 (30%), Positives = 113/219 (51%), Gaps = 11/219 (5%)
Query: 298 RQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEK 357
R+++E + +R Q E + L ++ REQ ER R +E + ++L+E +
Sbjct: 195 RRQEERLREQEERLREQEERLREQEERLCEQEERLREQEERLREQEERLCEQEERLREHE 254
Query: 358 ERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELK 417
ER ++ E L E Q ERL ++EE + R +Q E +LRE E+ + + +
Sbjct: 255 ERLCEQEERLCE---QEERLREQEERLHEQEERLCEQ--EERLREQEERLCEQEERLREQ 309
Query: 418 EEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLK 477
EE Q +R++E EE RL E +L + R EE ++ + +EE+E+L + +L
Sbjct: 310 EERLCEQEERLREQEE---RLCEQEKLPGQERLLEEVEKLLEQERRQEEQERLLERERLL 366
Query: 478 EEQERYI--ERAQQEKEEL-QQEMAQQSRSLQQAQQQLE 513
EE E + ER +Q+ E L QQE Q+ L++ ++ LE
Sbjct: 367 EEVEELLEQERLRQQDERLWQQETLQELERLRELERMLE 405
Score = 82.4 bits (202), Expect = 1e-15
Identities = 68/217 (31%), Positives = 111/217 (51%), Gaps = 17/217 (7%)
Query: 330 REQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQH 389
R++ E R+ A+ E L L +E +L+E E E R+ E L+E+EER Q
Sbjct: 170 RKELESVGRQLQAEVENNQMLSLLNRRQEERLREQE---ERLREQEERLREQEERLCEQE 226
Query: 390 RELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEAL-QLEVKA 448
L++ E +LRE E+ + + EE Q +R+ E EE + +E L + E +
Sbjct: 227 ERLREQ-EERLREQEERLCEQEERLREHEERLCEQEERLCEQEERLREQEERLHEQEERL 285
Query: 449 RRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQA 508
EE +R + RL E+EE +Q +L E++ER R Q+E+ Q+++ Q R L++
Sbjct: 286 CEQEERLREQEERLCEQEERLREQEERLCEQEERL--REQEERLCEQEKLPGQERLLEEV 343
Query: 509 QQQLEEVRQ--------NRQRADEDVE--AAQRKLRQ 535
++ LE+ R+ R+R E+VE Q +LRQ
Sbjct: 344 EKLLEQERRQEEQERLLERERLLEEVEELLEQERLRQ 380
Score = 70.1 bits (170), Expect = 6e-12
Identities = 53/186 (28%), Positives = 96/186 (51%), Gaps = 11/186 (5%)
Query: 349 RLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARA 408
+++QLQ+E +ELE R LQ E E + L + E +LRE E+
Sbjct: 158 KVEQLQDETNHLRKELE-------SVGRQLQAEVENNQMLSL-LNRRQEERLREQEERLR 209
Query: 409 SMQAEMELKEEEAARQRQRIKELEEMQQRLQEAL-QLEVKARRDEESVRIAQTRLLEEEE 467
+ + +EE Q +R++E EE + +E L + E + R EE + + RL E+EE
Sbjct: 210 EQEERLREQEERLCEQEERLREQEERLREQEERLCEQEERLREHEERLCEQEERLCEQEE 269
Query: 468 EKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVE 527
+Q +L E++ER E+ ++ +E+ ++ + +Q L++ +++L E ++ R R E+
Sbjct: 270 RLREQEERLHEQEERLCEQEERLREQ-EERLCEQEERLREQEERLCE-QEERLREQEERL 327
Query: 528 AAQRKL 533
Q KL
Sbjct: 328 CEQEKL 333
Score = 66.6 bits (161), Expect = 7e-11
Identities = 69/279 (24%), Positives = 126/279 (45%), Gaps = 29/279 (10%)
Query: 286 ANRTYEMSAS--DTRQRQEWTAAIQMAIRLQAEGKTSLH--KDLKQKRREQREQRERRRA 341
ANR +++ S DT + + A + EG+ S +DL+ + +E + A
Sbjct: 44 ANRKKKINGSSPDTATSGGYHSPGDSATGIYGEGRASSTTLEDLESQYQELAVALDSSSA 103
Query: 342 AKEEELLRLQQL-QEEKERKLQELELLQEAQRQAERL-------LQEEEERRRSQHRELQ 393
+ + L + KE K E+ L+Q+ R +L L E S+ +LQ
Sbjct: 104 IISQLTENINSLVRTSKEEKKHEIHLVQKLGRSLFKLKNQTAEPLAPEPPAGPSKVEQLQ 163
Query: 394 QALEGQLREAEQARASMQAEME----------LKEEEAARQRQRIKELEEMQQRLQEAL- 442
+E E +QAE+E +EE Q +R++E EE + +E L
Sbjct: 164 DETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQEERLREQEERLREQEERLC 223
Query: 443 QLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIE-----RAQQEK-EELQQ 496
+ E + R EE +R + RL E+EE + +L E++ER E R Q+E+ E ++
Sbjct: 224 EQEERLREQEERLREQEERLCEQEERLREHEERLCEQEERLCEQEERLREQEERLHEQEE 283
Query: 497 EMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQ 535
+ +Q L++ +++L E + + +E + + +LR+
Sbjct: 284 RLCEQEERLREQEERLCEQEERLREQEERLCEQEERLRE 322
Score = 57.0 bits (136), Expect = 5e-08
Identities = 51/207 (24%), Positives = 103/207 (49%), Gaps = 13/207 (6%)
Query: 269 EVLPDRDGKRCMFCVKTANRTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQK 328
E L + + + C + + + + R ++ + RL+ + + ++ + +
Sbjct: 248 ERLREHEERLCEQEERLCEQEERLREQEERLHEQEERLCEQEERLREQEERLCEQEERLR 307
Query: 329 RREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQ 388
+E+R + R ++EE L Q+ +ER L+E+E L E +R+ QEE+ER +
Sbjct: 308 EQEERLCEQEERLREQEERLCEQEKLPGQERLLEEVEKLLEQERR-----QEEQERLLER 362
Query: 389 HRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEAL---QLE 445
R L++ E L E E+ R Q + L ++E ++ +R++ELE M + EAL + E
Sbjct: 363 ERLLEEVEE--LLEQERLR---QQDERLWQQETLQELERLRELERMLELGWEALYEQRAE 417
Query: 446 VKARRDEESVRIAQTRLLEEEEEKLKQ 472
++ +E + T LE++ ++LK+
Sbjct: 418 PRSGFEELNNENKSTLQLEQQVKELKK 444
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 90.5 bits (223), Expect = 4e-18
Identities = 67/265 (25%), Positives = 140/265 (52%), Gaps = 29/265 (10%)
Query: 310 AIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKER------KLQE 363
A+ L+ T +++LK+K E +E+ + K E L +++L+ + ER ++Q
Sbjct: 170 ALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQT 229
Query: 364 LELLQEAQRQAERLLQEEEERRRSQHRELQQA-----LEGQLREAE-----QARASMQAE 413
L +E RQ E L ++E++ R+ + + +Q EG++RE E Q + + E
Sbjct: 230 NTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQE 289
Query: 414 MELKEEE-AARQRQRIKELEEMQQRLQEAL-QLEVKARRDEESVRIAQTRLLEEEEEKLK 471
EL+E+E R++++++E EE Q +E + + E K R EE + + RL E+E++ +
Sbjct: 290 KELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMRE 349
Query: 472 QLMQLKEEQERYIE-----RAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDV 526
Q ++++++ER E R ++E+ Q++M +Q +Q+ ++++ E + + +E +
Sbjct: 350 QEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQE-EERIREREKKMREEEETM 408
Query: 527 EAAQRKLRQASTNV-----KHWNVQ 546
+ K+++ N+ K W Q
Sbjct: 409 REQEEKMQKQEENMWEQEEKEWQQQ 433
Score = 87.8 bits (216), Expect = 3e-17
Identities = 69/253 (27%), Positives = 139/253 (54%), Gaps = 20/253 (7%)
Query: 295 SDTRQRQEWTAAIQMA-----IRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLR 349
++T Q + W ++ IR Q E + L+++ + REQ E+ R ++E+ LR
Sbjct: 229 TNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMR--RQEKRLR 286
Query: 350 LQQLQ-EEKERKLQELELLQEAQRQA---ERLLQEEEERRRSQHRELQQALEGQLREAEQ 405
Q+ + E+E++L+E + L+E + Q E + E+EE+ R Q ++ + E +L E E+
Sbjct: 287 EQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQ-EERLWEQEK 345
Query: 406 ARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEE 465
+ +M +EE Q +R++E EE + R QE + + + ++EE +R + ++ EE
Sbjct: 346 QMREQEQKMRDQEERMWEQDERLREKEE-RMREQEKMWEQEEKMQEEERIREREKKMREE 404
Query: 466 EEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSL---QQAQQQLEEV--RQNRQ 520
EE +Q ++++++E E Q+EKE QQ + +Q L ++ Q+Q E++ ++ +
Sbjct: 405 EETMREQEEKMQKQEENMWE--QEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKI 462
Query: 521 RADEDVEAAQRKL 533
R E++ ++K+
Sbjct: 463 RDQEEMWGQEKKM 475
Score = 87.0 bits (214), Expect = 5e-17
Identities = 63/246 (25%), Positives = 137/246 (55%), Gaps = 30/246 (12%)
Query: 316 EGKTSLHKDLKQKRREQR--EQRERRRA-----AKEEELLRLQQLQEEKERKLQELELLQ 368
E K L + K + +E++ EQ E+ R +E+++ R ++++E++++ ++ E ++
Sbjct: 437 EQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMR 496
Query: 369 EAQR----QAERL------LQEEEERRRSQHRELQQALEGQLREA----EQARASMQAEM 414
+ ++ Q ER+ L+E+EER R Q + QQ E ++RE EQ + + E
Sbjct: 497 DQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQ--EEKMREEKKTQEQEKKTWDQEE 554
Query: 415 ELKEEEAARQRQR-IKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQL 473
+++EEE R+R++ ++E EEM + +E +Q + + R++E Q ++E+EEK+ +
Sbjct: 555 KMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQ 614
Query: 474 MQLKEEQERYIERAQQEKEEL----QQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAA 529
+ EQE E QE+EE+ +++M +Q + + ++++ E + + +E ++
Sbjct: 615 EEKMWEQEE--EDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQ 672
Query: 530 QRKLRQ 535
+ K+R+
Sbjct: 673 EEKMRE 678
Score = 86.7 bits (213), Expect = 6e-17
Identities = 62/249 (24%), Positives = 134/249 (53%), Gaps = 11/249 (4%)
Query: 291 EMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRL 350
E+ + + R++ + RL+ + ++ K +R+E+R + + + ++E+ LR
Sbjct: 242 ELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELRE 301
Query: 351 QQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASM 410
Q+ E+E ++QE E ++ Q E++ ++EE+ R + R +Q E Q+RE EQ
Sbjct: 302 QKKLREQEEQMQEQE--EKMWEQEEKMREQEEKMWRQEERLWEQ--EKQMREQEQKMRDQ 357
Query: 411 QAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEE--E 468
+ M ++E + +R++E E+M ++ +E +Q E + R E+ +R + + E+EE +
Sbjct: 358 EERMWEQDERLREKEERMREQEKMWEQ-EEKMQEEERIREREKKMREEEETMREQEEKMQ 416
Query: 469 KLKQLMQLKEEQERYIERAQQEKEEL--QQEMAQQSRSLQQAQQQLEEVRQNRQRADEDV 526
K ++ M +EE+E +R ++KE+L Q++M +Q + + ++++ + Q E
Sbjct: 417 KQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRD--QEEMWGQEKK 474
Query: 527 EAAQRKLRQ 535
Q K+R+
Sbjct: 475 MWRQEKMRE 483
Score = 86.3 bits (212), Expect = 8e-17
Identities = 54/229 (23%), Positives = 123/229 (53%), Gaps = 6/229 (2%)
Query: 299 QRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQ--EE 356
Q++ W +M + + + D ++K RE+ RER + +EEE + +Q + +E
Sbjct: 526 QKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQE 585
Query: 357 KERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMEL 416
+E K++E E ++ Q E++ ++EE+ + + +Q E +++E E+ + +M+
Sbjct: 586 QEEKMREQE--EKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQE 643
Query: 417 KEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQL 476
+EE+ Q ++++E EE + +E +Q + + R++E Q + E+EEK++ +
Sbjct: 644 QEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEK 703
Query: 477 KEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEE-VRQNRQRADE 524
QE + Q+EK Q+EM ++ ++ +++++E + ++ +R E
Sbjct: 704 MWGQEEKM-WGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHEERCSE 751
Score = 85.9 bits (211), Expect = 1e-16
Identities = 65/272 (23%), Positives = 138/272 (50%), Gaps = 21/272 (7%)
Query: 291 EMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRL 350
+M + + R++ + RL + K ++ K + +E+R + R ++EE +R
Sbjct: 318 KMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMRE 377
Query: 351 QQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEG----QLREAEQA 406
Q+ E+E K+QE +E R+ E+ ++EEEE R Q ++Q+ E + +E +Q
Sbjct: 378 QEKMWEQEEKMQE----EERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQ 433
Query: 407 RASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEE 466
R Q E ++E+ Q ++I E EE + R QE + + K +E +R + ++ E+E
Sbjct: 434 RLPEQKEKLWEQEKMQEQEEKIWEQEE-KIRDQEEMWGQEKKMWRQEKMREQEDQMWEQE 492
Query: 467 EEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVR---------- 516
E+ Q ++ +++ER E+ ++ +E+ ++ M +Q + QQ ++ EE +
Sbjct: 493 EKMRDQEQKMWDQEERMWEQDERLREK-EERMREQKKMWQQEEKMREEKKTQEQEKKTWD 551
Query: 517 -QNRQRADEDVEAAQRKLRQASTNVKHWNVQM 547
+ + R +E + ++K+R+ ++ +M
Sbjct: 552 QEEKMREEERMREREKKMREEEEMMREQEEKM 583
Score = 84.0 bits (206), Expect = 4e-16
Identities = 52/213 (24%), Positives = 118/213 (55%), Gaps = 9/213 (4%)
Query: 326 KQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERR 385
++ R E++ Q + ++ +EE +R ++ E+E+K++E E E R+ E +QE+EE+
Sbjct: 534 EKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEE---EMMREQEEKMQEQEEKM 590
Query: 386 RSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQR---IKELEEMQQRLQEAL 442
R Q ++ + E +++E E+ + +M +EEE Q Q ++ E+MQ++ ++
Sbjct: 591 REQEEKMWEQ-EEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMW 649
Query: 443 QLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQS 502
+ E K R EE +R + ++ +EE+ +Q +++ ++E+ E+ ++ + + ++ Q+
Sbjct: 650 EQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEE 709
Query: 503 RSLQQAQQQ--LEEVRQNRQRADEDVEAAQRKL 533
+ Q ++ EE+R+ +R + E Q +L
Sbjct: 710 KMWGQEEKMWGQEEMREKEERIRDQKEKMQERL 742
Score = 83.6 bits (205), Expect = 5e-16
Identities = 53/225 (23%), Positives = 122/225 (54%), Gaps = 9/225 (4%)
Query: 329 RREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELL---QEAQRQAERLLQEEEERR 385
R ++ RE+++ ++EE +R ++ +E+E+K + E +E R+ E+ ++EEEE
Sbjct: 517 REKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMM 576
Query: 386 RSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEE---MQQRLQEAL 442
R Q ++Q+ E ++RE E+ + +M+ +EE+ Q +++ E EE MQ++ +
Sbjct: 577 REQEEKMQEQ-EEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMW 635
Query: 443 QLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQS 502
+ E K + EE + + ++ E+EE+ +Q +++ ++E+ R Q+EK + Q+E ++
Sbjct: 636 EQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKM--REQEEKMQGQEEKMREQ 693
Query: 503 RSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQM 547
+ Q++ ++ + E+ Q ++R+ ++ +M
Sbjct: 694 EEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKM 738
Score = 80.5 bits (197), Expect = 4e-15
Identities = 49/217 (22%), Positives = 115/217 (52%), Gaps = 7/217 (3%)
Query: 323 KDLKQKRREQREQ--RERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQA--ERLL 378
+D +QK +Q E+ + R ++EE +R Q+ ++E K++E + QE +++ +
Sbjct: 496 RDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEK 555
Query: 379 QEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRL 438
EEER R + +++++ E +RE E+ + +M +EE+ Q ++++E EE
Sbjct: 556 MREEERMREREKKMREE-EEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQ 614
Query: 439 QEAL--QLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQ 496
+E + Q E +++E + Q ++E+EEK+ + + EQE + +++ + ++
Sbjct: 615 EEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEE 674
Query: 497 EMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKL 533
+M +Q +Q ++++ E + + +E + + K+
Sbjct: 675 KMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKM 711
Score = 80.1 bits (196), Expect = 6e-15
Identities = 63/223 (28%), Positives = 122/223 (54%), Gaps = 22/223 (9%)
Query: 311 IRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEA 370
+R Q + K+L+++ +E REQ++ R +EE++ ++ E+E K++E E ++
Sbjct: 278 MRRQEKRLREQEKELREQEKELREQKKLRE--QEEQMQEQEEKMWEQEEKMREQE--EKM 333
Query: 371 QRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKE 430
RQ ERL ++E++ R E ++R+ E+ R Q E ++EE R+++++ E
Sbjct: 334 WRQEERLWEQEKQMREQ---------EQKMRDQEE-RMWEQDERLREKEERMREQEKMWE 383
Query: 431 LEEMQQRLQEALQLEVKARRDEESVRIAQTRL------LEEEEEKLKQLMQLKEEQERYI 484
EE Q + + E K R +EE++R + ++ + E+EEK Q +L E++E+
Sbjct: 384 QEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLW 443
Query: 485 ERAQ-QEKEELQQEMAQQSRSLQQAQQQLEEV-RQNRQRADED 525
E+ + QE+EE E ++ R ++ Q +++ RQ + R ED
Sbjct: 444 EQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQED 486
Score = 80.1 bits (196), Expect = 6e-15
Identities = 49/225 (21%), Positives = 127/225 (56%), Gaps = 13/225 (5%)
Query: 326 KQKRREQREQ---RERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEE 382
++K REQ +Q +E + +E+++ ++ E++ +L+E E E R+ +++ Q+EE
Sbjct: 478 QEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKE---ERMREQKKMWQQEE 534
Query: 383 ERRRSQHRELQQAL----EGQLREAEQARASMQAEMELKEEEAARQRQRIKELEE-MQQR 437
+ R + + Q+ E ++RE E+ R + +M +EE Q ++++E EE M+++
Sbjct: 535 KMREEKKTQEQEKKTWDQEEKMREEERMR-EREKKMREEEEMMREQEEKMQEQEEKMREQ 593
Query: 438 LQEALQLEVKARRDEESVRIAQTRLLE-EEEEKLKQLMQLKEEQERYIERAQQEKEELQQ 496
++ + E K + EE + + ++ E EEE+K+++ ++ EQE ++ +++ E ++
Sbjct: 594 EEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEE 653
Query: 497 EMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVK 541
+M +Q +++ +++++ + + +E ++ + K+R+ ++
Sbjct: 654 KMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMR 698
Score = 77.8 bits (190), Expect = 3e-14
Identities = 49/217 (22%), Positives = 113/217 (52%), Gaps = 7/217 (3%)
Query: 291 EMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRL 350
+M + + R+E Q E K + ++++ ++ RE+ E R +E+ +
Sbjct: 528 KMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQE 587
Query: 351 QQLQEEKERKLQELELLQEAQ----RQAERLLQEEEERRRSQHRELQQALEGQLREAEQA 406
++++E++E+ ++ E +QE + Q E++ ++EEE + + E+ E +++E E+
Sbjct: 588 EKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEK 647
Query: 407 RASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQ-LEVKARRDEESVRIAQTRLLEE 465
+ +M +EE+ Q ++++ EE + +E +Q E K R EE +R + ++ +
Sbjct: 648 MWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQ 707
Query: 466 EEEKLKQLMQL--KEEQERYIERAQQEKEELQQEMAQ 500
EE+ Q ++ +EE ER + +KE++Q+ + +
Sbjct: 708 EEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPE 744
Score = 77.4 bits (189), Expect = 4e-14
Identities = 53/227 (23%), Positives = 120/227 (52%), Gaps = 11/227 (4%)
Query: 314 QAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQR- 372
+ E K ++ +++ E+ +++E +EE+ + Q+L E+KE KL E E +QE +
Sbjct: 396 EREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKE-KLWEQEKMQEQEEK 454
Query: 373 ---QAERLLQEEE---ERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQ 426
Q E++ +EE + ++ +E + E Q+ E E+ + +M +EE Q +
Sbjct: 455 IWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDE 514
Query: 427 RIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIER 486
R++E EE + ++ Q E K R EE Q + ++EEK+++ +++E +++ E
Sbjct: 515 RLREKEERMREQKKMWQQEEKMR--EEKKTQEQEKKTWDQEEKMREEERMREREKKMREE 572
Query: 487 AQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKL 533
+ +E+ +++M +Q +++ ++++ E + Q +E + + K+
Sbjct: 573 EEMMREQ-EEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKM 618
Score = 72.8 bits (177), Expect = 9e-13
Identities = 56/263 (21%), Positives = 136/263 (51%), Gaps = 18/263 (6%)
Query: 284 KTANRTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAK 343
K + +M + R R++ + L+ + K ++ Q++ E+ ++E + +
Sbjct: 270 KMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQ 329
Query: 344 EEELLRLQQLQEEKERKLQELELLQEAQRQAERL------LQEEEERRRSQHRELQQALE 397
EE++ R ++ E+E++++E E Q+ + Q ER+ L+E+EER R Q + +Q E
Sbjct: 330 EEKMWRQEERLWEQEKQMREQE--QKMRDQEERMWEQDERLREKEERMREQEKMWEQ--E 385
Query: 398 GQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRI 457
+++E E+ R + E EEE R+++ + +E QE + + + R E+ ++
Sbjct: 386 EKMQEEERIREREKKMRE--EEETMREQEEKMQKQEENMWEQEEKEWQ-QQRLPEQKEKL 442
Query: 458 AQTRLLEEEEEKL-KQLMQLKEEQERYIER----AQQEKEELQQEMAQQSRSLQQAQQQL 512
+ ++E+EEK+ +Q ++++++E + + Q++ E + +M +Q ++ +Q++
Sbjct: 443 WEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKM 502
Query: 513 EEVRQNRQRADEDVEAAQRKLRQ 535
+ + DE + + ++R+
Sbjct: 503 WDQEERMWEQDERLREKEERMRE 525
Score = 71.2 bits (173), Expect = 3e-12
Identities = 61/228 (26%), Positives = 109/228 (47%), Gaps = 25/228 (10%)
Query: 334 EQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQ 393
E+ + R A EL R EE ++K EL+ + RL + E+ + +EL+
Sbjct: 162 EELTKERDALSLELYRNTITNEELKKKNAELQ-------EKLRLAESEKSEIQLNVKELK 214
Query: 394 QALEGQLREAEQARAS-MQAEMELKEEEAARQRQRIKELEEMQQRLQEAL-QLEVKARRD 451
+ LE Q + + +Q EM +EEE Q ++I++ EE R +E L + E K R
Sbjct: 215 RKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQ 274
Query: 452 EESVRIAQTRLLEEEEEKLKQLMQLKE-----EQERYIERAQQEKEELQQEMAQQSRSL- 505
EE +R + RL E+E+E +Q +L+E EQE ++ +++ E +++M +Q +
Sbjct: 275 EEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMW 334
Query: 506 ----------QQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHW 543
+Q ++Q +++R +R E E + K + K W
Sbjct: 335 RQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMW 382
Score = 70.9 bits (172), Expect = 3e-12
Identities = 58/285 (20%), Positives = 135/285 (47%), Gaps = 45/285 (15%)
Query: 298 RQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQE-- 355
R+R++ + +R Q E +++ ++ E++E +++R ++E+L +++QE
Sbjct: 395 REREKKMREEEETMREQEEKMQKQEENMWEQ--EEKEWQQQRLPEQKEKLWEQEKMQEQE 452
Query: 356 ----EKERKLQELELL---------QEAQRQAERLLQEEEERRRSQHRELQQALEGQLRE 402
E+E K+++ E + QE R+ E + E+EE+ R Q +++ E +
Sbjct: 453 EKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQ 512
Query: 403 AEQARASMQAEMELKEEEAARQRQRIKELEEMQQ------------------RLQEALQL 444
E+ R KEE Q++ ++ E+M++ R +E ++
Sbjct: 513 DERLRE--------KEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMRE 564
Query: 445 EVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSR- 503
K R+EE + Q ++E+EEK+++ + EQE ++ +++ E +++M +Q
Sbjct: 565 REKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEE 624
Query: 504 -SLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQM 547
+Q+ ++ + E + Q +E + + K+R+ ++ +M
Sbjct: 625 DKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKM 669
Score = 69.7 bits (169), Expect = 8e-12
Identities = 58/270 (21%), Positives = 130/270 (48%), Gaps = 31/270 (11%)
Query: 291 EMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRL 350
+M + + R + + RL+ E + + + K +E++ Q E R +E+++
Sbjct: 346 QMREQEQKMRDQEERMWEQDERLR-EKEERMREQEKMWEQEEKMQEEERIREREKKMREE 404
Query: 351 QQLQEEKERKLQELE----LLQEAQRQAERL------------LQEEEERRRSQHREL-- 392
++ E+E K+Q+ E +E + Q +RL +QE+EE+ Q ++
Sbjct: 405 EETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRD 464
Query: 393 QQALEGQ---------LREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQ 443
Q+ + GQ +RE E + +M +E++ Q +R+ E +E + +E ++
Sbjct: 465 QEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMR 524
Query: 444 LEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSR 503
+ K + EE +R + + +E+E+K + E+ER ER ++ +EE ++ M +Q
Sbjct: 525 EQKKMWQQEEKMR--EEKKTQEQEKKTWDQEEKMREEERMREREKKMREE-EEMMREQEE 581
Query: 504 SLQQAQQQLEEVRQNRQRADEDVEAAQRKL 533
+Q+ ++++ E + +E ++ + K+
Sbjct: 582 KMQEQEEKMREQEEKMWEQEEKMQEQEEKM 611
Score = 61.2 bits (147), Expect = 3e-09
Identities = 48/189 (25%), Positives = 96/189 (50%), Gaps = 15/189 (7%)
Query: 298 RQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQ-LQEE 356
R+++E + +R Q E + ++++ + EQ E+ +EE+ ++ Q+ + E
Sbjct: 577 REQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWE 636
Query: 357 KERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMEL 416
+E K+QE E E + E ++E+EE+ R Q E Q E ++RE E+ + +M
Sbjct: 637 QEEKMQEQE---EKMWEQEEKMREQEEKMREQ-EEKMQGQEEKMREQEEKMQGQEEKMRE 692
Query: 417 KEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQL 476
+EE+ Q +++ EE +E + + + R EE +R +++EK+++ +L
Sbjct: 693 QEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIR--------DQKEKMQE--RL 742
Query: 477 KEEQERYIE 485
E +ER E
Sbjct: 743 PEHEERCSE 751
Score = 58.9 bits (141), Expect = 1e-08
Identities = 43/214 (20%), Positives = 104/214 (48%), Gaps = 15/214 (7%)
Query: 292 MSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQ 351
M + + R+E + ++Q + + ++ K +E++ Q + + ++EE +
Sbjct: 562 MREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEE----K 617
Query: 352 QLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQ 411
++E+E K+QE E + Q E++ ++EE+ + + +Q E ++RE E+ +
Sbjct: 618 MWEQEEEDKMQEQEEMM--WEQEEKMQEQEEKMWEQEEKMREQ--EEKMREQEEKMQGQE 673
Query: 412 AEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLK 471
+M +EE+ Q ++++E EE + +E + + + +E Q + E+EE
Sbjct: 674 EKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEE---- 729
Query: 472 QLMQLKEEQERYIERAQQEKEELQQEMAQQSRSL 505
++++++E+ ER + +E + S+ L
Sbjct: 730 ---RIRDQKEKMQERLPEHEERCSEPCLPPSKVL 760
Score = 43.5 bits (101), Expect = 6e-04
Identities = 56/253 (22%), Positives = 109/253 (43%), Gaps = 36/253 (14%)
Query: 326 KQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAE--RLLQEEEE 383
++K Q ++ RR ++ +R+ Q K L Q+A R+ E L + ++
Sbjct: 72 EKKASHQHQEALRREIEAQDHTIRILTCQ--KTELETALYYSQDAARKFEDGNLGESKDL 129
Query: 384 RRRSQHR-----ELQQALEGQL---REAEQARASMQAEMELKEEEAARQRQRIKELEEMQ 435
R H ELQ+AL ++A++ + E + E R +EL++
Sbjct: 130 AGRLHHSWHFAGELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITNEELKKKN 189
Query: 436 QRLQEALQL-------------EVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQER 482
LQE L+L E+K + + + Q + +EE +Q +L+E++++
Sbjct: 190 AELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKK 249
Query: 483 YIERAQQEKEELQQE--------MAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLR 534
R Q+EK Q+E M +Q +++ +++L E ++ R E Q+KLR
Sbjct: 250 I--RKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLRE-QEKELREQEKELREQKKLR 306
Query: 535 QASTNVKHWNVQM 547
+ ++ +M
Sbjct: 307 EQEEQMQEQEEKM 319
Score = 42.0 bits (97), Expect = 0.002
Identities = 34/154 (22%), Positives = 70/154 (45%), Gaps = 20/154 (12%)
Query: 288 RTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEEL 347
+ +E D Q QE + + E K ++ ++ E+ ++E + +EE++
Sbjct: 617 KMWEQEEEDKMQEQE-------EMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKM 669
Query: 348 LRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQAR 407
++ E+E K+Q E E R+ E ++ +EE+ Q ++ ++ +
Sbjct: 670 QGQEEKMREQEEKMQGQE---EKMREQEEKMRGQEEKMWGQEEKMW---------GQEEK 717
Query: 408 ASMQAEMELKEEEAARQRQRIKE-LEEMQQRLQE 440
Q EM KEE Q+++++E L E ++R E
Sbjct: 718 MWGQEEMREKEERIRDQKEKMQERLPEHEERCSE 751
Score = 29.6 bits (65), Expect = 8.8
Identities = 37/164 (22%), Positives = 65/164 (39%), Gaps = 19/164 (11%)
Query: 397 EGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVR 456
EG ++ +AS Q + L+ E A Q I+ L + L+ AL A R E
Sbjct: 64 EGCHSPEDEKKASHQHQEALRREIEA-QDHTIRILTCQKTELETALYYSQDAARKFEDGN 122
Query: 457 IAQTRLLE-----------EEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSL 505
+ +++ L E + L + ++ +RYIE EL +E S L
Sbjct: 123 LGESKDLAGRLHHSWHFAGELQRALSAVSTWHKKADRYIE-------ELTKERDALSLEL 175
Query: 506 QQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNR 549
+ EE+++ E + A+ + + NVK ++ R
Sbjct: 176 YRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLER 219
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 90.1 bits (222), Expect = 5e-18
Identities = 57/226 (25%), Positives = 126/226 (55%), Gaps = 9/226 (3%)
Query: 299 QRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKE 358
Q+QE Q + E + ++ QK+ EQ +++E + +EE++ QEE+
Sbjct: 216 QKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMRE----QEEQM 271
Query: 359 RKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKE 418
R+ +E L Q+ Q + E E+EE+ R Q ++++ E Q+RE E+ + +M +E
Sbjct: 272 REQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQ-EEQMREQEEQMREQEEQMGKQE 330
Query: 419 EEAARQRQRIKELEEMQQRLQEAL-QLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLK 477
E+ Q++++ E +E + +E + + E + ++ EE VR + ++ ++EE+ KQ Q++
Sbjct: 331 EQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMR 390
Query: 478 EEQERYIERAQQ---EKEELQQEMAQQSRSLQQAQQQLEEVRQNRQ 520
+++E+ E+ +Q +KE+++++ Q +Q ++Q E + + ++
Sbjct: 391 KQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMGEQKE 436
Score = 88.6 bits (218), Expect = 2e-17
Identities = 49/234 (20%), Positives = 130/234 (55%), Gaps = 5/234 (2%)
Query: 314 QAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQ 373
+ EG+ + +++ Q ++E + +EE++ ++ +++E ++ E E E R+
Sbjct: 175 EQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQE---EQMRK 231
Query: 374 AERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEE 433
E + E+EE+ + Q ++Q+ E Q+R+ E+ + +M +EE+ +Q+++ ++ E+
Sbjct: 232 QEEQMGEQEEQVQKQEEQVQKQ-EEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQ 290
Query: 434 MQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEE 493
++ ++ + E + R EE +R + ++ E+EE+ KQ Q+ E++E+ E+ +Q ++
Sbjct: 291 TGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQ 350
Query: 494 LQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQM 547
+++M +Q +Q+ ++Q+ + + ++ +E + + ++R+ + QM
Sbjct: 351 -EEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQM 403
Score = 87.4 bits (215), Expect = 4e-17
Identities = 51/229 (22%), Positives = 127/229 (55%), Gaps = 7/229 (3%)
Query: 325 LKQKRREQREQ----RERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQE 380
++++ + REQ RE+ +E+E +Q + E++ Q E ++ Q+Q E++ ++
Sbjct: 166 VREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQ 225
Query: 381 EEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQE 440
EE+ R+ + + +Q E Q+++ E+ + +M +EE+ Q ++++E EE + +E
Sbjct: 226 EEQMRKQEEQMGEQ--EEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKE 283
Query: 441 ALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQ 500
+ E + EE +R + ++ E+EE+ +Q Q++E++E+ + + +++ E +++M +
Sbjct: 284 QTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQ-MGKQEEQMWEQKEQMWE 342
Query: 501 QSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNR 549
Q + + ++Q+ E + Q+ +E V + ++R+ ++ QM +
Sbjct: 343 QKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRK 391
Score = 87.4 bits (215), Expect = 4e-17
Identities = 57/221 (25%), Positives = 125/221 (56%), Gaps = 15/221 (6%)
Query: 298 RQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEK 357
R+++E + ++ Q E + ++++ + REQ E+ R +EE++L+ Q+ Q E+
Sbjct: 230 RKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMRE-QEEQMLK-QKEQTEQ 287
Query: 358 ERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEM-EL 416
E + E E E R+ E ++E+EE+ R Q E Q+RE E+ + +M E
Sbjct: 288 EEQTGEQE---EQMREQEEQMREQEEQMREQ--------EEQMREQEEQMGKQEEQMWEQ 336
Query: 417 KEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQL 476
KE+ ++ Q K+ E+M ++ ++ + E + R+ EE +R + ++ ++EE+ KQ Q+
Sbjct: 337 KEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQM 396
Query: 477 KEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQ 517
E++E+ E+ +Q +E+ +++M +Q +++ ++ + E ++
Sbjct: 397 GEQKEQMGEQKEQMREQ-EEQMGEQKEQMRKQEEHMGEQKE 436
Score = 84.7 bits (208), Expect = 2e-16
Identities = 50/229 (21%), Positives = 119/229 (51%), Gaps = 8/229 (3%)
Query: 327 QKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRR 386
Q R ++ + RE+ +E+E +Q + +E++ Q E QE Q + E+E +
Sbjct: 151 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE--QEGQMGEQEGQMGEQEEQM 208
Query: 387 SQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEV 446
+ E Q E Q+ E E+ + +M +EE+ +Q +++++ EE ++ +E ++ +
Sbjct: 209 GEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQE 268
Query: 447 KARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKE------ELQQEMAQ 500
+ R++E + Q E+EE+ +Q Q++E++E+ E+ +Q +E E +++M +
Sbjct: 269 EQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGK 328
Query: 501 QSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNR 549
Q + + ++Q+ E ++ + +E + + ++++ V+ QM +
Sbjct: 329 QEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRK 377
Score = 83.6 bits (205), Expect = 5e-16
Identities = 57/225 (25%), Positives = 126/225 (56%), Gaps = 7/225 (3%)
Query: 327 QKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQ-RQAERLLQEEEERR 385
Q R ++ + RE+ +E+E +Q + +E++ Q E QE Q R+ E ++E+E +
Sbjct: 109 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE--QEGQVREQEGQVREQEGQV 166
Query: 386 RSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEAL-QL 444
R Q ++++ EGQ+RE E + +M +E + Q +++ E EE Q+ +E + +
Sbjct: 167 REQEGQVREQ-EGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQ 225
Query: 445 EVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRS 504
E + R+ EE + + ++ ++EE+ KQ Q+++++E+ E+ +Q +E+ +++M +Q
Sbjct: 226 EEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQ-EEQMLKQKEQ 284
Query: 505 LQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNR 549
+Q +Q E+ Q R++ +E + + ++R+ ++ QM +
Sbjct: 285 TEQEEQTGEQEEQMREQ-EEQMREQEEQMREQEEQMREQEEQMGK 328
Score = 82.4 bits (202), Expect = 1e-15
Identities = 47/241 (19%), Positives = 130/241 (53%), Gaps = 15/241 (6%)
Query: 314 QAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQ 373
+ EG+ ++ ++ EQ +++E + +EE++ + ++ E+E ++Q+ E ++ Q+Q
Sbjct: 196 EQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQE--EQVQKQ 253
Query: 374 AERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQA-----EMELKEEEAARQRQRI 428
E++ +++EE+ R Q ++++ E L++ EQ Q +M +EE+ Q +++
Sbjct: 254 EEQM-RKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQM 312
Query: 429 KELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQ 488
+E EE + +E + + EE + + ++ E++E+ KQ Q+ E++E+ +++ +
Sbjct: 313 REQEEQMREQEEQM------GKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQ-MQKQE 365
Query: 489 QEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMN 548
++ + +++M +Q +++ ++Q+ + + E + + ++R+ + QM
Sbjct: 366 EQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMR 425
Query: 549 R 549
+
Sbjct: 426 K 426
Score = 81.3 bits (199), Expect = 3e-15
Identities = 51/223 (22%), Positives = 124/223 (55%), Gaps = 7/223 (3%)
Query: 327 QKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQ-RQAERLLQEEEERR 385
Q R ++ + RE+ +E+E +Q + +E++ Q E QE Q R+ E ++E+E +
Sbjct: 123 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE--QEGQVREQEGQVREQEGQV 180
Query: 386 RSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEAL-QL 444
R Q ++++ EGQ+ E E + +M +EE+ +Q +++ E EE ++ +E + +
Sbjct: 181 REQEGQVREQ-EGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQ 239
Query: 445 EVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRS 504
E + ++ EE V+ + ++ ++EE+ +Q Q++E++E+ ++ Q+E+ E +++ +Q
Sbjct: 240 EEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLK--QKEQTEQEEQTGEQEEQ 297
Query: 505 LQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQM 547
+++ ++Q+ E + + +E + + ++ + + QM
Sbjct: 298 MREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQM 340
Score = 76.6 bits (187), Expect = 6e-14
Identities = 52/223 (23%), Positives = 124/223 (55%), Gaps = 6/223 (2%)
Query: 327 QKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQ-RQAERLLQEEEERR 385
Q R ++ + RE+ +E+E +Q + +E++ Q E QE Q R+ E ++E+E +
Sbjct: 53 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE--QEGQVREQEGQVREQEGQV 110
Query: 386 RSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELE-EMQQRLQEALQL 444
R Q ++++ EGQ+RE E + ++ +E + Q +++E E +++++ + +
Sbjct: 111 REQEGQVREQ-EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ 169
Query: 445 EVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRS 504
E + R E VR + ++ E+E + +Q Q+ E++E+ E+ +Q +++ +++M +Q
Sbjct: 170 EGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQ-EEQMGEQEEQ 228
Query: 505 LQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQM 547
+++ ++Q+ E + Q+ +E V+ + ++R+ ++ QM
Sbjct: 229 MRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQM 271
Score = 72.0 bits (175), Expect = 2e-12
Identities = 52/222 (23%), Positives = 120/222 (54%), Gaps = 11/222 (4%)
Query: 327 QKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQ-RQAERLLQEEEERR 385
Q R ++ + RE+ +E+E +Q + +E++ Q E QE Q R+ E ++E+E +
Sbjct: 67 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE--QEGQVREQEGQVREQEGQV 124
Query: 386 RSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLE 445
R Q ++++ EGQ+RE E + ++ +E + Q +++E +E Q R QE
Sbjct: 125 REQEGQVREQ-EGQVREQEGQVREQEGQVREQEGQVREQEGQVRE-QEGQVREQEG---- 178
Query: 446 VKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSL 505
+ R E VR + ++ E+E + +Q Q+ E++E+ +++ +++ E +++M +Q +
Sbjct: 179 -QVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQ-MQKQEEQMGEQEEQMRKQEEQM 236
Query: 506 QQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQM 547
+ ++Q+++ + Q+ +E + + ++R+ ++ QM
Sbjct: 237 GEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQM 278
Score = 71.6 bits (174), Expect = 2e-12
Identities = 52/254 (20%), Positives = 127/254 (50%), Gaps = 18/254 (7%)
Query: 322 HKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQ--------RQ 373
+++LK+K E +E+ + K E L +++L+ + E ++ L QE Q R+
Sbjct: 6 NEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLET--DKIPLPQEGQVREQEGQVRE 63
Query: 374 AERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELE- 432
E ++E+E + R Q ++++ EGQ+RE E + ++ +E + Q +++E E
Sbjct: 64 QEGQVREQEGQVREQEGQVREQ-EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 122
Query: 433 EMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKE------EQERYIER 486
+++++ + + E + R E VR + ++ E+E + +Q Q++E EQE +
Sbjct: 123 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 182
Query: 487 AQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQ 546
+ + E + +M +Q + + ++Q+ E + Q+ +E + + ++R+ + Q
Sbjct: 183 QEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQ 242
Query: 547 MNRLMHPIEPGDKR 560
+ + ++ +++
Sbjct: 243 VQKQEEQVQKQEEQ 256
Score = 59.7 bits (143), Expect = 8e-09
Identities = 33/152 (21%), Positives = 82/152 (53%), Gaps = 5/152 (3%)
Query: 292 MSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQ 351
+ + +++E T + +R Q E + ++++ + REQ E+ +E+ + +
Sbjct: 279 LKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKE 338
Query: 352 QLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQ 411
Q+ E+KE+ ++ E + E + Q +Q++EE+ R Q ++++ E Q+R+ E+ +
Sbjct: 339 QMWEQKEQMWKQEEQMGEQEEQ----MQKQEEQVRKQEEQMRKQ-EEQMRKQEEQMRKQE 393
Query: 412 AEMELKEEEAARQRQRIKELEEMQQRLQEALQ 443
+M ++E+ Q+++++E EE +E ++
Sbjct: 394 EQMGEQKEQMGEQKEQMREQEEQMGEQKEQMR 425
Score = 47.8 bits (112), Expect = 3e-05
Identities = 39/185 (21%), Positives = 93/185 (50%), Gaps = 4/185 (2%)
Query: 366 LLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEE--AAR 423
+ E ++ LQEE + ++ E+Q ++ R+ E + + E +++E+E
Sbjct: 4 ITNEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVRE 63
Query: 424 QRQRIKELE-EMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQER 482
Q +++E E +++++ + + E + R E VR + ++ E+E + +Q Q++E++ +
Sbjct: 64 QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ 123
Query: 483 YIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKH 542
E+ Q +E+ Q Q+ + +Q Q E+ Q R++ + V + ++R+ V+
Sbjct: 124 VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ-EGQVREQEGQVREQEGQVRE 182
Query: 543 WNVQM 547
Q+
Sbjct: 183 QEGQV 187
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 86.7 bits (213), Expect = 6e-17
Identities = 86/334 (25%), Positives = 154/334 (46%), Gaps = 45/334 (13%)
Query: 290 YEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLR 349
YE S S+ + + + + + G+++L +D R Q+E +ER A + ++LL+
Sbjct: 321 YEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFL---RLQQENKERSEALRRQQLLQ 377
Query: 350 LQQLQEEKERKLQELELLQ---EAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQA 406
QQL+E++E K Q L Q E Q++ R L+E++ R R R QQ E + RE E+
Sbjct: 378 EQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARR--QQEREQRRREQEEK 435
Query: 407 RASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEE 466
R + E KEEE +R+R +E + +R QE ++ +++ ++ + + Q +LL+E
Sbjct: 436 RRLEELERRRKEEE---ERRRAEEEKRRVEREQEYIRRQLE--EEQRHLEVLQQQLLQE- 489
Query: 467 EEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDV 526
Q M L + + + + +QQ QQE ++ S + + E + R +V
Sbjct: 490 -----QAMLLHDHRRPHPQHSQQPPPP-QQERSKPSFHAPEPKAHYEPADRAR-----EV 538
Query: 527 EAAQRKLRQASTNVKHWNVQMNRLMHPIEPGDKRPVTSSSFSGFQP-------------- 572
E RK +S + + Q R++ P P ++ + P
Sbjct: 539 EDRFRKTNHSSPEAQ--SKQTGRVLEPPVPSRSESFSNGNSESVHPALQRPAEPQVPVRT 596
Query: 573 ----PLLAHRDSSLKRLTRWGSQGNRTPSPNSNE 602
P+L+ RDS L+ + SQ + S +S E
Sbjct: 597 TSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIE 630
Score = 78.6 bits (192), Expect = 2e-14
Identities = 61/197 (30%), Positives = 107/197 (54%), Gaps = 18/197 (9%)
Query: 322 HKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEE 381
H D +K+R ++++ E + EEE + + QE + + + +R RL QE
Sbjct: 305 HIDRTRKKRGEKDETEYEYSGSEEEEEEVPE-QEGEPSSIVNVPGESTLRRDFLRLQQEN 363
Query: 382 EERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEA 441
+ER + R+ Q E QLRE E E K + A +++RI++ +E ++RL+E
Sbjct: 364 KERSEALRRQ-QLLQEQQLREQE----------EYKRQLLAERQKRIEQQKEQRRRLEEQ 412
Query: 442 LQLEVKARRDEESVRIAQTRLLEEEEEKLKQL-MQLKEEQERYIERAQQEKEELQQEMAQ 500
+ E +ARR +E Q R +EE+ +L++L + KEE+ER RA++EK +++E
Sbjct: 413 QRREREARRQQER---EQRRREQEEKRRLEELERRRKEEEER--RRAEEEKRRVEREQEY 467
Query: 501 QSRSLQQAQQQLEEVRQ 517
R L++ Q+ LE ++Q
Sbjct: 468 IRRQLEEEQRHLEVLQQ 484
Score = 41.6 bits (96), Expect = 0.002
Identities = 31/160 (19%), Positives = 75/160 (46%), Gaps = 6/160 (3%)
Query: 375 ERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEM 434
E+LL+ R + R+++ L+ + + R E + E E + + +E+ E
Sbjct: 281 EQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRG----EKDETEYEYSGSEEEEEEVPEQ 336
Query: 435 QQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKE--EQERYIERAQQEKE 492
+ + + ++ + +R+ Q E + +QL+Q ++ EQE Y + E++
Sbjct: 337 EGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQ 396
Query: 493 ELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRK 532
+ ++ +Q R L++ Q++ E R+ ++R E +++
Sbjct: 397 KRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKR 436
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 84.7 bits (208), Expect = 2e-16
Identities = 75/236 (31%), Positives = 120/236 (50%), Gaps = 30/236 (12%)
Query: 290 YEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLR 349
YE S S+ + + + + + G+++L +D R Q+E +ER A + ++LL+
Sbjct: 321 YEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFL---RLQQENKERSEALRRQQLLQ 377
Query: 350 LQQLQEEKERKLQELELLQ---EAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQA 406
QQL+E++E K Q L Q E Q++ R L+E++ R R R QQ E + RE E+
Sbjct: 378 EQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARR--QQEREQRRREQEEK 435
Query: 407 RASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEE 466
R + E KEEE R+ EE ++R++ R++E +R R LEEE
Sbjct: 436 RRLEELERRRKEEEERRR------AEEEKRRVE----------REQEYIR----RQLEEE 475
Query: 467 EEKLKQL-MQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQR 521
+ L+ L QL +EQ +E +E EE +Q Q R LQQ Q L ++ + +R
Sbjct: 476 QRHLEVLQQQLLQEQAMLLECRWREMEEHRQAERLQ-RQLQQEQAYLLSLQHDHRR 530
Score = 83.6 bits (205), Expect = 5e-16
Identities = 58/214 (27%), Positives = 104/214 (48%), Gaps = 2/214 (0%)
Query: 322 HKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEE 381
H D +K+R ++++ E + EEE + + QE + + + +R RL QE
Sbjct: 305 HIDRTRKKRGEKDETEYEYSGSEEEEEEVPE-QEGEPSSIVNVPGESTLRRDFLRLQQEN 363
Query: 382 EERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEA 441
+ER + R+ Q E QLRE E+ + + AE + + E+ QR+R++E + ++ +
Sbjct: 364 KERSEALRRQ-QLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQ 422
Query: 442 LQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQ 501
+ E + R EE R+ + +EEE+ ++ + K ER E +++ EE Q+ +
Sbjct: 423 QEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVL 482
Query: 502 SRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQ 535
+ L Q Q L E R E QR+L+Q
Sbjct: 483 QQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQ 516
Score = 63.2 bits (152), Expect = 7e-10
Identities = 75/317 (23%), Positives = 138/317 (43%), Gaps = 43/317 (13%)
Query: 269 EVLPDRDGKRCMFC----VKTANRTYEMSASDTRQRQEWTAAIQMA----IRLQAEGKTS 320
E +P+++G+ T R + + ++R E Q+ +R Q E K
Sbjct: 331 EEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQ 390
Query: 321 LHKDLKQKRREQREQRER-RRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQ 379
L + +++ +Q+EQR R + E R QQ +E++ R+ +E L+E +R+ +
Sbjct: 391 LLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERR-----R 445
Query: 380 EEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRL- 438
+EEE RR E ++ RE E R ++ E + LE +QQ+L
Sbjct: 446 KEEEERRRAEEEKRRV----EREQEYIRRQLEEEQ--------------RHLEVLQQQLL 487
Query: 439 -QEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQE 497
++A+ LE + R EE R A+ RL + +++ L+ L+ + R + Q+ QQE
Sbjct: 488 QEQAMLLECRWREMEEH-RQAE-RLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPPPPQQE 545
Query: 498 MAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRLMHPIEPG 557
++ S + + E + R +VE RK +S + + Q R++ P P
Sbjct: 546 RSKPSFHAPEPKAHYEPADRAR-----EVEDRFRKTNHSSPEAQ--SKQTGRVLEPPVPS 598
Query: 558 DKRPVTSSSFSGFQPPL 574
++ + P L
Sbjct: 599 RSESFSNGNSESVHPAL 615
Score = 51.6 bits (122), Expect = 2e-06
Identities = 92/419 (21%), Positives = 164/419 (39%), Gaps = 66/419 (15%)
Query: 247 YFGSEECKEKRGIIPLDAHCCVEVLPDRDGKRCMFCVKTAN--RTYEMSASDTRQRQEWT 304
Y GSEE +E+ + V V + +R ++ N R+ + Q Q+
Sbjct: 323 YSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLR 382
Query: 305 AAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQEL 364
+ +L AE + + + +Q+RR + +QR R A +++E + ++ QEEK R+L+EL
Sbjct: 383 EQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEK-RRLEEL 441
Query: 365 ELL---QEAQRQAE---RLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKE 418
E +E +R+AE R ++ E+E R Q E Q+ LE ++ Q +A M E +E
Sbjct: 442 ERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQA-MLLECRWRE 500
Query: 419 EEAARQRQRIKELEEMQQRLQEALQLEVKA--------------RRDEESVRIAQTRLLE 464
E RQ +R++ + +Q +LQ + + R + S + +
Sbjct: 501 MEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHY 560
Query: 465 EEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADE 524
E ++ +++ + AQ ++ E SRS + E V QR E
Sbjct: 561 EPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVHPALQRPAE 620
Query: 525 -------------DVEAAQRKLRQASTNVKHWNVQMNRLMHPIEPGDKRPVTSSSFSGFQ 571
+V R + + K + + R P P ++ SS S +
Sbjct: 621 PQVQWSHLASLKNNVSPVSRSHSFSDPSPKFAHHHL-RSQDPCPPSRSEVLSQSSDSKSE 679
Query: 572 PP----------------------------LLAHRDSSLKRLTRWGSQGNRTPSPNSNE 602
P +L+ RDS L+ + SQ + S +S E
Sbjct: 680 APDPTQKAWSRSDSDEVPPRVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIE 738
Score = 41.6 bits (96), Expect = 0.002
Identities = 31/160 (19%), Positives = 75/160 (46%), Gaps = 6/160 (3%)
Query: 375 ERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEM 434
E+LL+ R + R+++ L+ + + R E + E E + + +E+ E
Sbjct: 281 EQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRG----EKDETEYEYSGSEEEEEEVPEQ 336
Query: 435 QQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKE--EQERYIERAQQEKE 492
+ + + ++ + +R+ Q E + +QL+Q ++ EQE Y + E++
Sbjct: 337 EGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQ 396
Query: 493 ELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRK 532
+ ++ +Q R L++ Q++ E R+ ++R E +++
Sbjct: 397 KRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKR 436
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.129 0.364
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,094,532
Number of Sequences: 37866
Number of extensions: 1250389
Number of successful extensions: 54704
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1232
Number of HSP's successfully gapped in prelim test: 1409
Number of HSP's that attempted gapping in prelim test: 8843
Number of HSP's gapped (non-prelim): 15171
length of query: 631
length of database: 18,247,518
effective HSP length: 108
effective length of query: 523
effective length of database: 14,157,990
effective search space: 7404628770
effective search space used: 7404628770
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.