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Search of human proteins with 109633026
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|109633026 serine/threonine protein kinase MST4 isoform 3
[Homo sapiens]
(354 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|109633026 serine/threonine protein kinase MST4 isoform 3 [Hom... 702 0.0
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 640 0.0
gi|109633028 serine/threonine protein kinase MST4 isoform 2 [Hom... 463 e-131
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 405 e-113
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 395 e-110
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 377 e-105
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 212 4e-55
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 209 2e-54
gi|22035600 mitogen-activated protein kinase kinase kinase kinas... 191 1e-48
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 182 4e-46
gi|38570135 mitogen-activated protein kinase kinase kinase kinas... 178 6e-45
gi|14589909 mitogen-activated protein kinase kinase kinase kinas... 178 6e-45
gi|110611908 mitogen-activated protein kinase kinase kinase kina... 171 7e-43
gi|6005810 mitogen-activated protein kinase kinase kinase kinase... 171 7e-43
gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens] 169 5e-42
gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens] 169 5e-42
gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens] 169 5e-42
gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens] 169 5e-42
gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens] 169 5e-42
gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens] 169 5e-42
gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens] 167 2e-41
gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens] 167 2e-41
gi|32483399 p21-activated kinase 2 [Homo sapiens] 162 6e-40
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 159 3e-39
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 159 3e-39
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 159 3e-39
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 159 3e-39
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 157 1e-38
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 157 1e-38
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 157 1e-38
>gi|109633026 serine/threonine protein kinase MST4 isoform 3 [Homo
sapiens]
Length = 354
Score = 702 bits (1813), Expect = 0.0
Identities = 354/354 (100%), Positives = 354/354 (100%)
Query: 1 MAHSPVAVQVPGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEA 60
MAHSPVAVQVPGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEA
Sbjct: 1 MAHSPVAVQVPGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEA 60
Query: 61 EDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQ 120
EDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQ
Sbjct: 61 EDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQ 120
Query: 121 IATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFV 180
IATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFV
Sbjct: 121 IATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFV 180
Query: 181 GTPFWMAPEVIQQSAYDSKRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDD 240
GTPFWMAPEVIQQSAYDSKRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDD
Sbjct: 181 GTPFWMAPEVIQQSAYDSKRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDD 240
Query: 241 ESDSEGSDSESTSRENNTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPAFA 300
ESDSEGSDSESTSRENNTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPAFA
Sbjct: 241 ESDSEGSDSESTSRENNTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPAFA 300
Query: 301 ELKQQDENNASRNQAIEELEKSIAVAEAACPGITDKMVKKLIEKFQKCSADESP 354
ELKQQDENNASRNQAIEELEKSIAVAEAACPGITDKMVKKLIEKFQKCSADESP
Sbjct: 301 ELKQQDENNASRNQAIEELEKSIAVAEAACPGITDKMVKKLIEKFQKCSADESP 354
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 640 bits (1650), Expect = 0.0
Identities = 343/416 (82%), Positives = 345/416 (82%), Gaps = 62/416 (14%)
Query: 1 MAHSPVAVQVPGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEA 60
MAHSPVAVQVPGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEA
Sbjct: 1 MAHSPVAVQVPGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEA 60
Query: 61 EDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQ 120
EDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQ
Sbjct: 61 EDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQ 120
Query: 121 IATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFV 180
IATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFV
Sbjct: 121 IATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFV 180
Query: 181 GTPFWMAPEVIQQSAYDSKRP------TAKELLKHK-------------FIVKNSKKT-- 219
GTPFWMAPEVIQQSAYDSK TA EL K + I KN+ T
Sbjct: 181 GTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLV 240
Query: 220 -----------------------------------------SYLTELIDRFKRWKAEGHS 238
SYLTELIDRFKRWKAEGHS
Sbjct: 241 GDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHS 300
Query: 239 DDESDSEGSDSESTSRENNTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPA 298
DDESDSEGSDSESTSRENNTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPA
Sbjct: 301 DDESDSEGSDSESTSRENNTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPA 360
Query: 299 FAELKQQDENNASRNQAIEELEKSIAVAEAACPGITDKMVKKLIEKFQKCSADESP 354
FAELKQQDENNASRNQAIEELEKSIAVAEAACPGITDKMVKKLIEKFQKCSADESP
Sbjct: 361 FAELKQQDENNASRNQAIEELEKSIAVAEAACPGITDKMVKKLIEKFQKCSADESP 416
>gi|109633028 serine/threonine protein kinase MST4 isoform 2 [Homo
sapiens]
Length = 339
Score = 463 bits (1192), Expect = e-131
Identities = 252/327 (77%), Positives = 256/327 (78%), Gaps = 62/327 (18%)
Query: 90 LKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAAN 149
++GSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAAN
Sbjct: 13 MQGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAAN 72
Query: 150 VLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKRP------TA 203
VLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSK TA
Sbjct: 73 VLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITA 132
Query: 204 KELLKHK-------------FIVKNSKKT------------------------------- 219
EL K + I KN+ T
Sbjct: 133 IELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELL 192
Query: 220 ------------SYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRENNTHPEWSFTTV 267
SYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRENNTHPEWSFTTV
Sbjct: 193 KHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRENNTHPEWSFTTV 252
Query: 268 RKKPDPKKVQNGAEQDLVQTLSCLSMIITPAFAELKQQDENNASRNQAIEELEKSIAVAE 327
RKKPDPKKVQNGAEQDLVQTLSCLSMIITPAFAELKQQDENNASRNQAIEELEKSIAVAE
Sbjct: 253 RKKPDPKKVQNGAEQDLVQTLSCLSMIITPAFAELKQQDENNASRNQAIEELEKSIAVAE 312
Query: 328 AACPGITDKMVKKLIEKFQKCSADESP 354
AACPGITDKMVKKLIEKFQKCSADESP
Sbjct: 313 AACPGITDKMVKKLIEKFQKCSADESP 339
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 405 bits (1042), Expect = e-113
Identities = 230/408 (56%), Positives = 273/408 (66%), Gaps = 73/408 (17%)
Query: 14 QNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITV 73
Q++ DPEELFTKL+RIGKGSFGEV+KGIDN T++VVAIKIIDLEEAEDEIEDIQQEITV
Sbjct: 10 QHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITV 69
Query: 74 LSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLD 133
LSQCDS Y+T+Y+GSYLK +KLWIIMEYLGGGSALDLL+ GP +E IAT+L+EILKGLD
Sbjct: 70 LSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLD 129
Query: 134 YLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQ 193
YLHSE+KIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI+Q
Sbjct: 130 YLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQ 189
Query: 194 SAYDSKRP------TAKELLKHK-------------FIVKNS------------------ 216
SAYD K TA EL K + I KNS
Sbjct: 190 SAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEA 249
Query: 217 -------------------------KKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSES 251
KKTS+LTELIDR+KRWK+EGH +ES SE SD +
Sbjct: 250 CLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSEGHG-EESSSEDSDIDG 308
Query: 252 TSRENNTHPEWSF-TTVRKKPDPK--------KVQNGAEQDLVQTLS-CLSMIITPAFAE 301
+ + P W+F T+R P K Q AE Q S CLS ++ P F E
Sbjct: 309 EAEDGEQGPIWTFPPTIRPSPHSKLHKGTALHSSQKPAEPVKRQPRSQCLSTLVRPVFGE 368
Query: 302 LKQQDENNASRNQAIEELEKSIAVAEAACPGITDKMVKKLIEKFQKCS 349
LK++ + + A+EELE + ++AE +CPGI+DK++ L+E+ Q+ S
Sbjct: 369 LKEKHKQSGGSVGALEELENAFSLAEESCPGISDKLMVHLVERVQRFS 416
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 395 bits (1014), Expect = e-110
Identities = 238/424 (56%), Positives = 279/424 (65%), Gaps = 77/424 (18%)
Query: 1 MAHSPVAVQVPGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEA 60
MAHSPV +PGMQN ADPEELFTKLE+IGKGSFGEVFKGIDNRTQ+VVAIKIIDLEEA
Sbjct: 1 MAHSPVQSGLPGMQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEA 60
Query: 61 EDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQ 120
EDEIEDIQQEITVLSQCDS YVTKYYGSYLK +KLWIIMEYLGGGSALDLL GP DE Q
Sbjct: 61 EDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQ 120
Query: 121 IATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFV 180
IAT+L+EILKGLDYLHSEKKIHRDIKAANVLLSE G+VKLADFGVAGQLTDTQIKRNTFV
Sbjct: 121 IATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFV 180
Query: 181 GTPFWMAPEVIQQSAYDSKRP------TAKELLKHK-------------FIVKNSKKT-- 219
GTPFWMAPEVI+QSAYDSK TA EL + + I KN+ T
Sbjct: 181 GTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLE 240
Query: 220 ----SYLTELIDR---------------------FKRWKAEGHSDDESD------SEGSD 248
L E ++ + K + + D +E S
Sbjct: 241 GNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSH 300
Query: 249 SESTSRENNTHPE-----------WSFTTVRKKPDPKKVQNGAEQ--DLVQT-------- 287
+S+S +++ + W F T+R+K DPK ++NGA Q DL +
Sbjct: 301 DDSSSEDSDAETDGQASGGSDSGDWIF-TIREK-DPKNLENGALQPSDLDRNKMKDIPKR 358
Query: 288 --LSCLSMIITPAFAELKQQDENNASRNQAIEELEKSIAVAEAACPGITDKMVKKLIEKF 345
CLS II+P FAELK++ + +IEEL +I +AE ACPGI+D MV +L+++
Sbjct: 359 PFSQCLSTIISPLFAELKEKSQACGGNLGSIEELRGAIYLAEEACPGISDTMVAQLVQRL 418
Query: 346 QKCS 349
Q+ S
Sbjct: 419 QRYS 422
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 377 bits (969), Expect = e-105
Identities = 230/415 (55%), Positives = 271/415 (65%), Gaps = 78/415 (18%)
Query: 11 PGMQNNI-ADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQ 69
PG N+ ADPEELFTKLE+IGKGSFGEVFKGIDNRTQ+VVAIKIIDLEEAEDEIEDIQQ
Sbjct: 22 PGGSTNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQ 81
Query: 70 EITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEIL 129
EITVLSQCDS YVTKYYGSYLK +KLWIIMEYLGGGSALDLL GP DE QIAT+L+EIL
Sbjct: 82 EITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREIL 141
Query: 130 KGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPE 189
KGLDYLHSEKKIHRDIKAANVLLSE G+VKLADFGVAGQLTDTQIKRNTFVGTPFWMAPE
Sbjct: 142 KGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPE 201
Query: 190 VIQQSAYDSKRP------TAKELLKHK-------------FIVKNSKKT------SYLTE 224
VI+QSAYDSK TA EL + + I KN+ T L E
Sbjct: 202 VIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKE 261
Query: 225 LIDR---------------------FKRWKAEGHSDDESD------SEGSDSESTSRENN 257
++ + K + + D +E S +S+S +++
Sbjct: 262 FVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSD 321
Query: 258 THPE-----------WSFTTVRKKPDPKKVQNGAEQ--DLVQT----------LSCLSMI 294
+ W F T+R+K DPK ++NGA Q DL + CLS I
Sbjct: 322 AETDGQASGGSDSGDWIF-TIREK-DPKNLENGALQPSDLDRNKMKDIPKRPFSQCLSTI 379
Query: 295 ITPAFAELKQQDENNASRNQAIEELEKSIAVAEAACPGITDKMVKKLIEKFQKCS 349
I+P FAELK++ + +IEEL +I +AE ACPGI+D MV +L+++ Q+ S
Sbjct: 380 ISPLFAELKEKSQACGGNLGSIEELRGAIYLAEEACPGISDTMVAQLVQRLQRYS 434
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 212 bits (540), Expect = 4e-55
Identities = 105/180 (58%), Positives = 134/180 (74%), Gaps = 5/180 (2%)
Query: 20 PEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDS 79
PEE+F LE++G+GS+G VFK I + QVVAIK + +E ++++I +EI+++ QCDS
Sbjct: 23 PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVES---DLQEIIKEISIMQQCDS 79
Query: 80 SYVTKYYGSYLKGSKLWIIMEYLGGGSALDL--LRAGPFDEFQIATMLKEILKGLDYLHS 137
YV KYYGSY K + LWI+MEY G GS D+ LR E +IAT+LK LKGL+YLH
Sbjct: 80 PYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHF 139
Query: 138 EKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYD 197
+KIHRDIKA N+LL+ +G KLADFGVAGQLTDT KRNT +GTPFWMAPEVIQ+ Y+
Sbjct: 140 MRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYN 199
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 209 bits (533), Expect = 2e-54
Identities = 102/180 (56%), Positives = 134/180 (74%), Gaps = 5/180 (2%)
Query: 20 PEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDS 79
PEE+F LE++G+GS+G V+K I T Q+VAIK + +E ++++I +EI+++ QCDS
Sbjct: 26 PEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVES---DLQEIIKEISIMQQCDS 82
Query: 80 SYVTKYYGSYLKGSKLWIIMEYLGGGSALDL--LRAGPFDEFQIATMLKEILKGLDYLHS 137
+V KYYGSY K + LWI+MEY G GS D+ LR E +IAT+L+ LKGL+YLH
Sbjct: 83 PHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHF 142
Query: 138 EKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYD 197
+KIHRDIKA N+LL+ +G KLADFGVAGQLTDT KRNT +GTPFWMAPEVIQ+ Y+
Sbjct: 143 MRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYN 202
>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
[Homo sapiens]
Length = 820
Score = 191 bits (484), Expect = 1e-48
Identities = 92/176 (52%), Positives = 128/176 (72%), Gaps = 2/176 (1%)
Query: 16 NIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLS 75
++ DP + F L+R+G G++G+V+K D T ++ A+KI+ L+ +D I +QQEIT+L
Sbjct: 8 SLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDD-ISSLQQEITILR 66
Query: 76 QCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRA-GPFDEFQIATMLKEILKGLDY 134
+C V Y GSYL+ +LWI ME+ GGGS ++ A GP +E QIA + +E LKGL +
Sbjct: 67 ECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLHH 126
Query: 135 LHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEV 190
LHS+ KIHRDIK AN+LL+ QGDVKLADFGV+G+LT + KR +F+GTP+WMAPEV
Sbjct: 127 LHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEV 182
Score = 28.5 bits (62), Expect = 9.5
Identities = 13/30 (43%), Positives = 22/30 (73%), Gaps = 1/30 (3%)
Query: 199 KRPTAKELLKHKFIVKNSKKTSYLTELIDR 228
KRPTA++LL+H F + + + LT+L+D+
Sbjct: 260 KRPTAEKLLQHPFTTQQLPR-ALLTQLLDK 288
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 182 bits (462), Expect = 4e-46
Identities = 90/181 (49%), Positives = 124/181 (68%), Gaps = 2/181 (1%)
Query: 11 PGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQE 70
PG + +P+E F ++RIG G++G+V+K + T ++ AIK+I LE ED +QQE
Sbjct: 3 PGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGED-FAVVQQE 61
Query: 71 ITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRA-GPFDEFQIATMLKEIL 129
I ++ C + Y+GSYL+ KLWI ME+ GGGS D+ GP E QIA + +E L
Sbjct: 62 IIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETL 121
Query: 130 KGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPE 189
+GL YLHS+ K+HRDIK AN+LL++ G VKLADFGV+ Q+T T KR +F+GTP+WMAPE
Sbjct: 122 QGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPE 181
Query: 190 V 190
V
Sbjct: 182 V 182
Score = 33.1 bits (74), Expect = 0.39
Identities = 28/86 (32%), Positives = 43/86 (50%), Gaps = 10/86 (11%)
Query: 199 KRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSD-DESDSEGSDS-----EST 252
KRPTA++LL+H F+ ++ + S EL+D+ + D D+ D E + ST
Sbjct: 260 KRPTAEKLLQHPFVTQHLTR-SLAIELLDKVNNPDHSTYHDFDDDDPEPLVAVPHRIHST 318
Query: 253 S---RENNTHPEWSFTTVRKKPDPKK 275
S RE T E +F V+ P +K
Sbjct: 319 SRNVREEKTRSEITFGQVKFDPPLRK 344
>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 178 bits (452), Expect = 6e-45
Identities = 86/173 (49%), Positives = 122/173 (70%), Gaps = 2/173 (1%)
Query: 19 DPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
+P++ + ++R+G G++G+V+K + T ++ A+KII LE +D IQQEI ++ +C
Sbjct: 15 NPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD-FSLIQQEIFMVKECK 73
Query: 79 SSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRA-GPFDEFQIATMLKEILKGLDYLHS 137
+ Y+GSYL KLWI MEY GGGS D+ GP E QIA + +E L+GL YLH+
Sbjct: 74 HCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHT 133
Query: 138 EKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEV 190
+ K+HRDIK AN+LL++ GDVKLADFGVA ++T T KR +F+GTP+WMAPEV
Sbjct: 134 KGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEV 186
Score = 31.6 bits (70), Expect = 1.1
Identities = 14/47 (29%), Positives = 22/47 (46%)
Query: 199 KRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSE 245
KRPTA+ LL H F+ + + EL+D+ H + D +
Sbjct: 264 KRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDDD 310
>gi|14589909 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 178 bits (452), Expect = 6e-45
Identities = 86/173 (49%), Positives = 122/173 (70%), Gaps = 2/173 (1%)
Query: 19 DPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
+P++ + ++R+G G++G+V+K + T ++ A+KII LE +D IQQEI ++ +C
Sbjct: 15 NPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD-FSLIQQEIFMVKECK 73
Query: 79 SSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRA-GPFDEFQIATMLKEILKGLDYLHS 137
+ Y+GSYL KLWI MEY GGGS D+ GP E QIA + +E L+GL YLH+
Sbjct: 74 HCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHT 133
Query: 138 EKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEV 190
+ K+HRDIK AN+LL++ GDVKLADFGVA ++T T KR +F+GTP+WMAPEV
Sbjct: 134 KGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEV 186
Score = 31.6 bits (70), Expect = 1.1
Identities = 14/47 (29%), Positives = 22/47 (46%)
Query: 199 KRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSE 245
KRPTA+ LL H F+ + + EL+D+ H + D +
Sbjct: 264 KRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDDD 310
>gi|110611908 mitogen-activated protein kinase kinase kinase kinase
1 isoform 1 [Homo sapiens]
Length = 821
Score = 171 bits (434), Expect = 7e-43
Identities = 80/173 (46%), Positives = 123/173 (71%), Gaps = 2/173 (1%)
Query: 19 DPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
DP + + L+R+G G++GEVFK D + +VA+K++ +E +D++ +Q+EI +L C
Sbjct: 12 DPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEP-DDDVSTLQKEILILKTCR 70
Query: 79 SSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRA-GPFDEFQIATMLKEILKGLDYLHS 137
+ + Y+GSYL KLWI ME+ G GS D+ + G E QI+ + +E+L+GL YLHS
Sbjct: 71 HANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHS 130
Query: 138 EKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEV 190
+KKIHRDIK AN+L+++ G+V+LADFG++ Q+ T +R +F+GTP+WMAPEV
Sbjct: 131 QKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEV 183
>gi|6005810 mitogen-activated protein kinase kinase kinase kinase 1
isoform 2 [Homo sapiens]
Length = 833
Score = 171 bits (434), Expect = 7e-43
Identities = 80/173 (46%), Positives = 123/173 (71%), Gaps = 2/173 (1%)
Query: 19 DPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
DP + + L+R+G G++GEVFK D + +VA+K++ +E +D++ +Q+EI +L C
Sbjct: 12 DPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEP-DDDVSTLQKEILILKTCR 70
Query: 79 SSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRA-GPFDEFQIATMLKEILKGLDYLHS 137
+ + Y+GSYL KLWI ME+ G GS D+ + G E QI+ + +E+L+GL YLHS
Sbjct: 71 HANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHS 130
Query: 138 EKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEV 190
+KKIHRDIK AN+L+++ G+V+LADFG++ Q+ T +R +F+GTP+WMAPEV
Sbjct: 131 QKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEV 183
>gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens]
Length = 559
Score = 169 bits (427), Expect = 5e-42
Identities = 84/184 (45%), Positives = 122/184 (66%), Gaps = 1/184 (0%)
Query: 16 NIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLS 75
++ DP++ +T+ E+IG+G+ G V+ +D T Q VAIK ++L++ + + E I EI V+
Sbjct: 275 SVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQ-QPKKELIINEILVMR 333
Query: 76 QCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYL 135
+ + + Y SYL G +LW++MEYL GGS D++ DE QIA + +E L+ LD+L
Sbjct: 334 ENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFL 393
Query: 136 HSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSA 195
HS + IHRDIK+ N+LL G VKL DFG Q+T Q KR+T VGTP+WMAPEV+ + A
Sbjct: 394 HSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA 453
Query: 196 YDSK 199
Y K
Sbjct: 454 YGPK 457
>gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens]
Length = 565
Score = 169 bits (427), Expect = 5e-42
Identities = 84/184 (45%), Positives = 122/184 (66%), Gaps = 1/184 (0%)
Query: 16 NIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLS 75
++ DP++ +T+ E+IG+G+ G V+ +D T Q VAIK ++L++ + + E I EI V+
Sbjct: 281 SVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQ-QPKKELIINEILVMR 339
Query: 76 QCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYL 135
+ + + Y SYL G +LW++MEYL GGS D++ DE QIA + +E L+ LD+L
Sbjct: 340 ENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFL 399
Query: 136 HSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSA 195
HS + IHRDIK+ N+LL G VKL DFG Q+T Q KR+T VGTP+WMAPEV+ + A
Sbjct: 400 HSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA 459
Query: 196 YDSK 199
Y K
Sbjct: 460 YGPK 463
>gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens]
Length = 580
Score = 169 bits (427), Expect = 5e-42
Identities = 84/184 (45%), Positives = 122/184 (66%), Gaps = 1/184 (0%)
Query: 16 NIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLS 75
++ DP++ +T+ E+IG+G+ G V+ +D T Q VAIK ++L++ + + E I EI V+
Sbjct: 296 SVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQ-QPKKELIINEILVMR 354
Query: 76 QCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYL 135
+ + + Y SYL G +LW++MEYL GGS D++ DE QIA + +E L+ LD+L
Sbjct: 355 ENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFL 414
Query: 136 HSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSA 195
HS + IHRDIK+ N+LL G VKL DFG Q+T Q KR+T VGTP+WMAPEV+ + A
Sbjct: 415 HSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA 474
Query: 196 YDSK 199
Y K
Sbjct: 475 YGPK 478
>gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 169 bits (427), Expect = 5e-42
Identities = 84/184 (45%), Positives = 122/184 (66%), Gaps = 1/184 (0%)
Query: 16 NIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLS 75
++ DP++ +T+ E+IG+G+ G V+ +D T Q VAIK ++L++ + + E I EI V+
Sbjct: 260 SVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQ-QPKKELIINEILVMR 318
Query: 76 QCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYL 135
+ + + Y SYL G +LW++MEYL GGS D++ DE QIA + +E L+ LD+L
Sbjct: 319 ENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFL 378
Query: 136 HSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSA 195
HS + IHRDIK+ N+LL G VKL DFG Q+T Q KR+T VGTP+WMAPEV+ + A
Sbjct: 379 HSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA 438
Query: 196 YDSK 199
Y K
Sbjct: 439 YGPK 442
>gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 169 bits (427), Expect = 5e-42
Identities = 84/184 (45%), Positives = 122/184 (66%), Gaps = 1/184 (0%)
Query: 16 NIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLS 75
++ DP++ +T+ E+IG+G+ G V+ +D T Q VAIK ++L++ + + E I EI V+
Sbjct: 260 SVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQ-QPKKELIINEILVMR 318
Query: 76 QCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYL 135
+ + + Y SYL G +LW++MEYL GGS D++ DE QIA + +E L+ LD+L
Sbjct: 319 ENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFL 378
Query: 136 HSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSA 195
HS + IHRDIK+ N+LL G VKL DFG Q+T Q KR+T VGTP+WMAPEV+ + A
Sbjct: 379 HSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA 438
Query: 196 YDSK 199
Y K
Sbjct: 439 YGPK 442
>gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 169 bits (427), Expect = 5e-42
Identities = 84/184 (45%), Positives = 122/184 (66%), Gaps = 1/184 (0%)
Query: 16 NIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLS 75
++ DP++ +T+ E+IG+G+ G V+ +D T Q VAIK ++L++ + + E I EI V+
Sbjct: 260 SVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQ-QPKKELIINEILVMR 318
Query: 76 QCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYL 135
+ + + Y SYL G +LW++MEYL GGS D++ DE QIA + +E L+ LD+L
Sbjct: 319 ENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFL 378
Query: 136 HSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSA 195
HS + IHRDIK+ N+LL G VKL DFG Q+T Q KR+T VGTP+WMAPEV+ + A
Sbjct: 379 HSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA 438
Query: 196 YDSK 199
Y K
Sbjct: 439 YGPK 442
>gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens]
Length = 553
Score = 167 bits (422), Expect = 2e-41
Identities = 83/184 (45%), Positives = 122/184 (66%), Gaps = 1/184 (0%)
Query: 16 NIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLS 75
++ DP++ +T+ E+IG+G+ G V+ +D T Q VAIK ++L++ + + E I EI V+
Sbjct: 262 SVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQ-QPKKELIINEILVMR 320
Query: 76 QCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYL 135
+ + + Y SYL G +LW++MEYL GGS D++ DE QIA + +E L+ L++L
Sbjct: 321 ENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFL 380
Query: 136 HSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSA 195
HS + IHRDIK+ N+LL G VKL DFG Q+T Q KR+T VGTP+WMAPEV+ + A
Sbjct: 381 HSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA 440
Query: 196 YDSK 199
Y K
Sbjct: 441 YGPK 444
>gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens]
Length = 545
Score = 167 bits (422), Expect = 2e-41
Identities = 83/184 (45%), Positives = 122/184 (66%), Gaps = 1/184 (0%)
Query: 16 NIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLS 75
++ DP++ +T+ E+IG+G+ G V+ +D T Q VAIK ++L++ + + E I EI V+
Sbjct: 262 SVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQ-QPKKELIINEILVMR 320
Query: 76 QCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYL 135
+ + + Y SYL G +LW++MEYL GGS D++ DE QIA + +E L+ L++L
Sbjct: 321 ENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFL 380
Query: 136 HSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSA 195
HS + IHRDIK+ N+LL G VKL DFG Q+T Q KR+T VGTP+WMAPEV+ + A
Sbjct: 381 HSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA 440
Query: 196 YDSK 199
Y K
Sbjct: 441 YGPK 444
Score = 29.6 bits (65), Expect = 4.3
Identities = 24/67 (35%), Positives = 30/67 (44%), Gaps = 11/67 (16%)
Query: 181 GTPFWMAPEVIQQSAYD----------SKRPTAKELLKHKFIVKNSKKTSYLTELIDRFK 230
GTP PE + D KR +AKELL+H+F+ K +K S LT LI K
Sbjct: 480 GTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFL-KIAKPLSSLTPLIAAAK 538
Query: 231 RWKAEGH 237
H
Sbjct: 539 EATKNNH 545
>gi|32483399 p21-activated kinase 2 [Homo sapiens]
Length = 524
Score = 162 bits (409), Expect = 6e-40
Identities = 83/184 (45%), Positives = 121/184 (65%), Gaps = 1/184 (0%)
Query: 16 NIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLS 75
+I DP++ +T+ E+IG+G+ G VF D Q VAIK I+L++ + + E I EI V+
Sbjct: 241 SIGDPKKKYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQK-QPKKELIINEILVMK 299
Query: 76 QCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYL 135
+ + + + SYL G +L+++MEYL GGS D++ DE QIA + +E L+ L++L
Sbjct: 300 ELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFL 359
Query: 136 HSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSA 195
H+ + IHRDIK+ NVLL +G VKL DFG Q+T Q KR+T VGTP+WMAPEV+ + A
Sbjct: 360 HANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA 419
Query: 196 YDSK 199
Y K
Sbjct: 420 YGPK 423
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 159 bits (403), Expect = 3e-39
Identities = 85/185 (45%), Positives = 123/185 (66%), Gaps = 12/185 (6%)
Query: 17 IADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQ 76
+ DP +F +E +G G++G+V+KG +T Q+ AIK++D+ EDE E+I+QEI +L +
Sbjct: 18 LRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKQEINMLKK 75
Query: 77 CDSSY-VTKYYGSYLKGS------KLWIIMEYLGGGSALDLLR---AGPFDEFQIATMLK 126
+ YYG+++K S +LW++ME+ G GS DL++ E IA + +
Sbjct: 76 YSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICR 135
Query: 127 EILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWM 186
EIL+GL +LH+ K IHRDIK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WM
Sbjct: 136 EILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
Query: 187 APEVI 191
APEVI
Sbjct: 196 APEVI 200
Score = 28.5 bits (62), Expect = 9.5
Identities = 25/122 (20%), Positives = 54/122 (44%), Gaps = 21/122 (17%)
Query: 200 RPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRENNTH 259
RP ++LLK FI + +L D R + + +E++ E S SE E+++H
Sbjct: 277 RPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSE---EEDDSH 333
Query: 260 PEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPAFAELKQQDENNASRNQAIEEL 319
E + +P + N + ++ F L+Q++++N+ + ++L
Sbjct: 334 GE--------EGEPSSIMNVPGESTLRR----------EFLRLQQENKSNSEALKQQQQL 375
Query: 320 EK 321
++
Sbjct: 376 QQ 377
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 159 bits (403), Expect = 3e-39
Identities = 85/185 (45%), Positives = 123/185 (66%), Gaps = 12/185 (6%)
Query: 17 IADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQ 76
+ DP +F +E +G G++G+V+KG +T Q+ AIK++D+ EDE E+I+QEI +L +
Sbjct: 18 LRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKQEINMLKK 75
Query: 77 CDSSY-VTKYYGSYLKGS------KLWIIMEYLGGGSALDLLR---AGPFDEFQIATMLK 126
+ YYG+++K S +LW++ME+ G GS DL++ E IA + +
Sbjct: 76 YSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICR 135
Query: 127 EILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWM 186
EIL+GL +LH+ K IHRDIK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WM
Sbjct: 136 EILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
Query: 187 APEVI 191
APEVI
Sbjct: 196 APEVI 200
Score = 28.5 bits (62), Expect = 9.5
Identities = 25/122 (20%), Positives = 54/122 (44%), Gaps = 21/122 (17%)
Query: 200 RPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRENNTH 259
RP ++LLK FI + +L D R + + +E++ E S SE E+++H
Sbjct: 277 RPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSE---EEDDSH 333
Query: 260 PEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPAFAELKQQDENNASRNQAIEEL 319
E + +P + N + ++ F L+Q++++N+ + ++L
Sbjct: 334 GE--------EGEPSSIMNVPGESTLRR----------EFLRLQQENKSNSEALKQQQQL 375
Query: 320 EK 321
++
Sbjct: 376 QQ 377
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 159 bits (403), Expect = 3e-39
Identities = 85/185 (45%), Positives = 123/185 (66%), Gaps = 12/185 (6%)
Query: 17 IADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQ 76
+ DP +F +E +G G++G+V+KG +T Q+ AIK++D+ EDE E+I+QEI +L +
Sbjct: 18 LRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKQEINMLKK 75
Query: 77 CDSSY-VTKYYGSYLKGS------KLWIIMEYLGGGSALDLLR---AGPFDEFQIATMLK 126
+ YYG+++K S +LW++ME+ G GS DL++ E IA + +
Sbjct: 76 YSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICR 135
Query: 127 EILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWM 186
EIL+GL +LH+ K IHRDIK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WM
Sbjct: 136 EILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
Query: 187 APEVI 191
APEVI
Sbjct: 196 APEVI 200
Score = 28.5 bits (62), Expect = 9.5
Identities = 25/122 (20%), Positives = 54/122 (44%), Gaps = 21/122 (17%)
Query: 200 RPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRENNTH 259
RP ++LLK FI + +L D R + + +E++ E S SE E+++H
Sbjct: 277 RPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSE---EEDDSH 333
Query: 260 PEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPAFAELKQQDENNASRNQAIEEL 319
E + +P + N + ++ F L+Q++++N+ + ++L
Sbjct: 334 GE--------EGEPSSIMNVPGESTLRR----------EFLRLQQENKSNSEALKQQQQL 375
Query: 320 EK 321
++
Sbjct: 376 QQ 377
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 159 bits (403), Expect = 3e-39
Identities = 85/185 (45%), Positives = 123/185 (66%), Gaps = 12/185 (6%)
Query: 17 IADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQ 76
+ DP +F +E +G G++G+V+KG +T Q+ AIK++D+ EDE E+I+QEI +L +
Sbjct: 18 LRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKQEINMLKK 75
Query: 77 CDSSY-VTKYYGSYLKGS------KLWIIMEYLGGGSALDLLR---AGPFDEFQIATMLK 126
+ YYG+++K S +LW++ME+ G GS DL++ E IA + +
Sbjct: 76 YSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICR 135
Query: 127 EILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWM 186
EIL+GL +LH+ K IHRDIK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WM
Sbjct: 136 EILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
Query: 187 APEVI 191
APEVI
Sbjct: 196 APEVI 200
Score = 28.5 bits (62), Expect = 9.5
Identities = 25/122 (20%), Positives = 54/122 (44%), Gaps = 21/122 (17%)
Query: 200 RPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRENNTH 259
RP ++LLK FI + +L D R + + +E++ E S SE E+++H
Sbjct: 277 RPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSE---EEDDSH 333
Query: 260 PEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPAFAELKQQDENNASRNQAIEEL 319
E + +P + N + ++ F L+Q++++N+ + ++L
Sbjct: 334 GE--------EGEPSSIMNVPGESTLRR----------EFLRLQQENKSNSEALKQQQQL 375
Query: 320 EK 321
++
Sbjct: 376 QQ 377
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 157 bits (397), Expect = 1e-38
Identities = 83/185 (44%), Positives = 121/185 (65%), Gaps = 12/185 (6%)
Query: 17 IADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQ 76
+ DP +F +E +G G++G+V+KG +T Q+ AIK++D+ DE E+I+QEI +L +
Sbjct: 18 LRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKK 75
Query: 77 CDSSY-VTKYYGSYLKGS------KLWIIMEYLGGGSALDLLR---AGPFDEFQIATMLK 126
+ YYG+++K + +LW++ME+ G GS DL++ E IA + +
Sbjct: 76 YSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICR 135
Query: 127 EILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWM 186
EIL+GL +LH K IHRDIK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WM
Sbjct: 136 EILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
Query: 187 APEVI 191
APEVI
Sbjct: 196 APEVI 200
Score = 38.5 bits (88), Expect = 0.009
Identities = 20/61 (32%), Positives = 31/61 (50%)
Query: 198 SKRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRENN 257
S+RP ++L+KH FI + +L D R K + DE++ E S SE EN+
Sbjct: 275 SQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEND 334
Query: 258 T 258
+
Sbjct: 335 S 335
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 157 bits (397), Expect = 1e-38
Identities = 83/185 (44%), Positives = 121/185 (65%), Gaps = 12/185 (6%)
Query: 17 IADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQ 76
+ DP +F +E +G G++G+V+KG +T Q+ AIK++D+ DE E+I+QEI +L +
Sbjct: 18 LRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKK 75
Query: 77 CDSSY-VTKYYGSYLKGS------KLWIIMEYLGGGSALDLLR---AGPFDEFQIATMLK 126
+ YYG+++K + +LW++ME+ G GS DL++ E IA + +
Sbjct: 76 YSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICR 135
Query: 127 EILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWM 186
EIL+GL +LH K IHRDIK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WM
Sbjct: 136 EILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
Query: 187 APEVI 191
APEVI
Sbjct: 196 APEVI 200
Score = 38.5 bits (88), Expect = 0.009
Identities = 20/61 (32%), Positives = 31/61 (50%)
Query: 198 SKRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRENN 257
S+RP ++L+KH FI + +L D R K + DE++ E S SE EN+
Sbjct: 275 SQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEND 334
Query: 258 T 258
+
Sbjct: 335 S 335
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 157 bits (397), Expect = 1e-38
Identities = 83/185 (44%), Positives = 121/185 (65%), Gaps = 12/185 (6%)
Query: 17 IADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQ 76
+ DP +F +E +G G++G+V+KG +T Q+ AIK++D+ DE E+I+QEI +L +
Sbjct: 18 LRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKK 75
Query: 77 CDSSY-VTKYYGSYLKGS------KLWIIMEYLGGGSALDLLR---AGPFDEFQIATMLK 126
+ YYG+++K + +LW++ME+ G GS DL++ E IA + +
Sbjct: 76 YSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICR 135
Query: 127 EILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWM 186
EIL+GL +LH K IHRDIK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WM
Sbjct: 136 EILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
Query: 187 APEVI 191
APEVI
Sbjct: 196 APEVI 200
Score = 38.5 bits (88), Expect = 0.009
Identities = 20/61 (32%), Positives = 31/61 (50%)
Query: 198 SKRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRENN 257
S+RP ++L+KH FI + +L D R K + DE++ E S SE EN+
Sbjct: 275 SQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEND 334
Query: 258 T 258
+
Sbjct: 335 S 335
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.130 0.366
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,018,110
Number of Sequences: 37866
Number of extensions: 552642
Number of successful extensions: 3997
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 722
Number of HSP's successfully gapped in prelim test: 119
Number of HSP's that attempted gapping in prelim test: 2003
Number of HSP's gapped (non-prelim): 1077
length of query: 354
length of database: 18,247,518
effective HSP length: 103
effective length of query: 251
effective length of database: 14,347,320
effective search space: 3601177320
effective search space used: 3601177320
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.