Search of human proteins with 14196455

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|14196455 protocadherin gamma subfamily A, 11 isoform 3
precursor [Homo sapiens]
         (750 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|14196455 protocadherin gamma subfamily A, 11 isoform 3 precur...  1488   0.0  
gi|14196451 protocadherin gamma subfamily A, 11 isoform 2 precur...  1233   0.0  
gi|11128039 protocadherin gamma subfamily A, 11 isoform 1 precur...  1233   0.0  
gi|8850232 protocadherin gamma subfamily A, 12 isoform 1 precurs...   865   0.0  
gi|14196457 protocadherin gamma subfamily A, 12 isoform 2 precur...   865   0.0  
gi|14270484 protocadherin gamma subfamily A, 8 isoform 1 precurs...   852   0.0  
gi|7662056 protocadherin gamma subfamily A, 8 isoform 2 precurso...   852   0.0  
gi|14196468 protocadherin gamma subfamily A, 4 isoform 2 precurs...   849   0.0  
gi|11056026 protocadherin gamma subfamily A, 4 isoform 1 precurs...   849   0.0  
gi|11128041 protocadherin gamma subfamily A, 10 isoform 1 precur...   848   0.0  
gi|14196448 protocadherin gamma subfamily A, 10 isoform 2 precur...   848   0.0  
gi|14196471 protocadherin gamma subfamily A, 5 isoform 2 precurs...   843   0.0  
gi|11056024 protocadherin gamma subfamily A, 5 isoform 1 precurs...   843   0.0  
gi|11056032 protocadherin gamma subfamily A, 1 isoform 1 precurs...   834   0.0  
gi|14196459 protocadherin gamma subfamily A, 1 isoform 2 precurs...   834   0.0  
gi|14589880 protocadherin gamma subfamily A, 3 isoform 1 precurs...   831   0.0  
gi|14196465 protocadherin gamma subfamily A, 3 isoform 2 precurs...   831   0.0  
gi|11056065 protocadherin gamma subfamily A, 6 isoform 1 precurs...   828   0.0  
gi|14196474 protocadherin gamma subfamily A, 6 isoform 2 precurs...   828   0.0  
gi|11056063 protocadherin gamma subfamily A, 7 isoform 1 precurs...   822   0.0  
gi|14196477 protocadherin gamma subfamily A, 7 isoform 2 precurs...   822   0.0  
gi|11128043 protocadherin gamma subfamily A, 9 isoform 1 precurs...   812   0.0  
gi|14270487 protocadherin gamma subfamily A, 9 isoform 2 precurs...   812   0.0  
gi|11056030 protocadherin gamma subfamily A, 2 isoform 1 precurs...   798   0.0  
gi|14196462 protocadherin gamma subfamily A, 2 isoform 2 precurs...   798   0.0  
gi|14270508 protocadherin gamma subfamily B, 7 isoform 2 precurs...   613   e-175
gi|11128027 protocadherin gamma subfamily B, 7 isoform 1 precurs...   613   e-175
gi|14270505 protocadherin gamma subfamily B, 5 isoform 2 precurs...   602   e-172
gi|11128031 protocadherin gamma subfamily B, 5 isoform 1 precurs...   602   e-172
gi|11128029 protocadherin gamma subfamily B, 6 isoform 1 precurs...   596   e-170

>gi|14196455 protocadherin gamma subfamily A, 11 isoform 3 precursor
           [Homo sapiens]
          Length = 750

 Score = 1488 bits (3851), Expect = 0.0
 Identities = 750/750 (100%), Positives = 750/750 (100%)

Query: 1   MANRLQRGDRSRLLLLLCIFLGTLRGFRARQIRYSVPEETEKGSFVGNISKDLGLEPREL 60
           MANRLQRGDRSRLLLLLCIFLGTLRGFRARQIRYSVPEETEKGSFVGNISKDLGLEPREL
Sbjct: 1   MANRLQRGDRSRLLLLLCIFLGTLRGFRARQIRYSVPEETEKGSFVGNISKDLGLEPREL 60

Query: 61  AKRGVRIVSRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGV 120
           AKRGVRIVSRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGV
Sbjct: 61  AKRGVRIVSRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGV 120

Query: 121 EVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFS 180
           EVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFS
Sbjct: 121 EVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFS 180

Query: 181 LQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHI 240
           LQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHI
Sbjct: 181 LQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHI 240

Query: 241 PMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTG 300
           PMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTG
Sbjct: 241 PMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTG 300

Query: 301 EVQVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILEN 360
           EVQVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILEN
Sbjct: 301 EVQVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILEN 360

Query: 361 SPPGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDRELVQSYN 420
           SPPGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDRELVQSYN
Sbjct: 361 SPPGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDRELVQSYN 420

Query: 421 ITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDP 480
           ITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDP
Sbjct: 421 ITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDP 480

Query: 481 DSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGD 540
           DSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGD
Sbjct: 481 DSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGD 540

Query: 541 PPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSG 600
           PPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSG
Sbjct: 541 PPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSG 600

Query: 601 QNAWLSYRLLKASEPGLFAVGEHTGEQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQ 660
           QNAWLSYRLLKASEPGLFAVGEHTGEQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQ
Sbjct: 601 QNAWLSYRLLKASEPGLFAVGEHTGEQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQ 660

Query: 661 FDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNA 720
           FDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNA
Sbjct: 661 FDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNA 720

Query: 721 TLTNAAGKRDGKAPAGGNGNKKKSGKKEKK 750
           TLTNAAGKRDGKAPAGGNGNKKKSGKKEKK
Sbjct: 721 TLTNAAGKRDGKAPAGGNGNKKKSGKKEKK 750


>gi|14196451 protocadherin gamma subfamily A, 11 isoform 2 precursor
           [Homo sapiens]
          Length = 837

 Score = 1233 bits (3191), Expect = 0.0
 Identities = 626/626 (100%), Positives = 626/626 (100%)

Query: 1   MANRLQRGDRSRLLLLLCIFLGTLRGFRARQIRYSVPEETEKGSFVGNISKDLGLEPREL 60
           MANRLQRGDRSRLLLLLCIFLGTLRGFRARQIRYSVPEETEKGSFVGNISKDLGLEPREL
Sbjct: 1   MANRLQRGDRSRLLLLLCIFLGTLRGFRARQIRYSVPEETEKGSFVGNISKDLGLEPREL 60

Query: 61  AKRGVRIVSRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGV 120
           AKRGVRIVSRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGV
Sbjct: 61  AKRGVRIVSRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGV 120

Query: 121 EVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFS 180
           EVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFS
Sbjct: 121 EVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFS 180

Query: 181 LQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHI 240
           LQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHI
Sbjct: 181 LQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHI 240

Query: 241 PMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTG 300
           PMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTG
Sbjct: 241 PMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTG 300

Query: 301 EVQVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILEN 360
           EVQVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILEN
Sbjct: 301 EVQVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILEN 360

Query: 361 SPPGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDRELVQSYN 420
           SPPGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDRELVQSYN
Sbjct: 361 SPPGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDRELVQSYN 420

Query: 421 ITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDP 480
           ITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDP
Sbjct: 421 ITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDP 480

Query: 481 DSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGD 540
           DSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGD
Sbjct: 481 DSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGD 540

Query: 541 PPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSG 600
           PPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSG
Sbjct: 541 PPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSG 600

Query: 601 QNAWLSYRLLKASEPGLFAVGEHTGE 626
           QNAWLSYRLLKASEPGLFAVGEHTGE
Sbjct: 601 QNAWLSYRLLKASEPGLFAVGEHTGE 626



 Score =  153 bits (386), Expect = 6e-37
 Identities = 164/585 (28%), Positives = 248/585 (42%), Gaps = 72/585 (12%)

Query: 70  RGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEII--DI 127
           RG+T   A NP    L+  G +DRE+     +   L   L   D ++   V + ++  D+
Sbjct: 184 RGRTD-GAKNPE---LVLEGSLDREK---EAAHLLLLTALDGGDPIRKGAVPIRVVVLDV 236

Query: 128 NDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVN-----SLQSYQLSPNNYFSLQ 182
           ND+ P F +    + V E+   G R  + NA DPD G+N     S ++ +   +  F L 
Sbjct: 237 NDHIPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLD 296

Query: 183 LRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPM 242
                  ++  E+ + GSLD EK   + + +   DGG       + I VV  DVND+ P 
Sbjct: 297 -------SQTGEVQVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVV--DVNDNAPE 347

Query: 243 FTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTG-- 300
            T +    S+ EN   GT + ++N  D D G NG+V     N        F+L+   G  
Sbjct: 348 ITITSSINSILENSPPGTVIALLNVQDQDSGENGQVSCFIPNHLP-----FKLEKTYGNY 402

Query: 301 -EVQVRGSLDFEKYRFYEMEIQGQDGGG--LFTTTTMLITVVDVNDNAPEITITSSINSI 357
            ++     LD E  + Y + +   D G   L   T + + V D NDN P    +S    I
Sbjct: 403 YKLITSRVLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYI 462

Query: 358 LENSPPGTVIALLNVQDQDSGENGQVSCF--------IPNHLPFKLEKTYGNYYKLITSR 409
            EN+P G  I  +   D DS +N  V+          +P      +    G  Y L   +
Sbjct: 463 PENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYAL---Q 519

Query: 410 VLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPP--VFPH-----SSYSAYI 462
             D E  +   + + A D G PPLS+   + L V D NDN P  ++P      S+     
Sbjct: 520 SFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELA 579

Query: 463 PENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFD 522
           P +   G  +  V A+D DS QNA ++Y L   +  G+      ++  +TG +   ++  
Sbjct: 580 PRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGL-----FAVGEHTGEVRTARALL 634

Query: 523 YEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRS 582
                   L V  +D G PPLS+ V+L++ V    D+ PE+L      +     E +  S
Sbjct: 635 DRDALKQSLVVAVQDHGQPPLSATVTLTVAVA---DSIPEVLADLGSLESLANSETSDLS 691

Query: 583 AEPGYLVTKVVAVD----------KDSGQNAWLSYRLLKASEPGL 617
               YLV  V AV                  W   RLL+ASE GL
Sbjct: 692 L---YLVVAVAAVSCIFLVFVIVLLALRLWRWHKSRLLQASEGGL 733


>gi|11128039 protocadherin gamma subfamily A, 11 isoform 1 precursor
           [Homo sapiens]
          Length = 935

 Score = 1233 bits (3191), Expect = 0.0
 Identities = 626/626 (100%), Positives = 626/626 (100%)

Query: 1   MANRLQRGDRSRLLLLLCIFLGTLRGFRARQIRYSVPEETEKGSFVGNISKDLGLEPREL 60
           MANRLQRGDRSRLLLLLCIFLGTLRGFRARQIRYSVPEETEKGSFVGNISKDLGLEPREL
Sbjct: 1   MANRLQRGDRSRLLLLLCIFLGTLRGFRARQIRYSVPEETEKGSFVGNISKDLGLEPREL 60

Query: 61  AKRGVRIVSRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGV 120
           AKRGVRIVSRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGV
Sbjct: 61  AKRGVRIVSRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGV 120

Query: 121 EVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFS 180
           EVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFS
Sbjct: 121 EVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFS 180

Query: 181 LQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHI 240
           LQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHI
Sbjct: 181 LQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHI 240

Query: 241 PMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTG 300
           PMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTG
Sbjct: 241 PMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTG 300

Query: 301 EVQVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILEN 360
           EVQVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILEN
Sbjct: 301 EVQVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILEN 360

Query: 361 SPPGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDRELVQSYN 420
           SPPGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDRELVQSYN
Sbjct: 361 SPPGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDRELVQSYN 420

Query: 421 ITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDP 480
           ITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDP
Sbjct: 421 ITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDP 480

Query: 481 DSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGD 540
           DSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGD
Sbjct: 481 DSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGD 540

Query: 541 PPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSG 600
           PPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSG
Sbjct: 541 PPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSG 600

Query: 601 QNAWLSYRLLKASEPGLFAVGEHTGE 626
           QNAWLSYRLLKASEPGLFAVGEHTGE
Sbjct: 601 QNAWLSYRLLKASEPGLFAVGEHTGE 626



 Score =  367 bits (941), Expect = e-101
 Identities = 267/753 (35%), Positives = 379/753 (50%), Gaps = 101/753 (13%)

Query: 33  RYSVPEETEKGS---FVGNISKDLGLEPRELAKRGVRIVSRGKTQLFAVNPRSGSLITAG 89
           R SVPE    G+    V     D G+    +     R +    +++F ++ ++G +   G
Sbjct: 249 RVSVPENISSGTRVLMVNATDPDEGINGEVMYS--FRNMESKASEIFQLDSQTGEVQVRG 306

Query: 90  RIDREELCETVSSCFLNMELLVEDTLKIYGVE---VEIIDINDNAPSFQEDEVEIKVSEH 146
            +D E+        F  ME+  +D   ++      + ++D+NDNAP          + E+
Sbjct: 307 SLDFEKYR------FYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILEN 360

Query: 147 AIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGAKNPELVLEGSLDREKE 206
           + PG   AL N +D D G N   S  +  +  F L+   +T G    +L+    LDRE  
Sbjct: 361 SPPGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLE---KTYG-NYYKLITSRVLDRELV 416

Query: 207 AAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVPENISSGTRVLMVN 266
            ++ + LTA D G P       + + V D ND+ P+F  S Y   +PEN   G  +  V 
Sbjct: 417 QSYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVT 476

Query: 267 ATDPDEGINGEVMYSFRNMESKA---SEIFQLDSQTGEVQVRGSLDFEKYRFYEMEIQGQ 323
           A DPD   N  V YS  +   +    S    ++S TG +    S D+E++R  E+ +  +
Sbjct: 477 ALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIAR 536

Query: 324 DGGG--LFTTTTMLITVVDVNDNAPEITI-------TSSINSILENSPPGTVIALLNVQD 374
           D G   L +  ++ + V+D NDNAPEI         ++ +     ++ PG ++  +   D
Sbjct: 537 DSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVD 596

Query: 375 QDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSR-VLDRELVQSYNITLTATDQGSPPL 433
           +DSG+N  +S  +       L     +  ++ T+R +LDR+ ++  ++ +   D G PPL
Sbjct: 597 KDSGQNAWLSYRLLKASEPGLFAVGEHTGEVRTARALLDRDALKQ-SLVVAVQDHGQPPL 655

Query: 434 SAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDS----------- 482
           SA   + + VAD    P V         +  +     S++ V A+   S           
Sbjct: 656 SATVTLTVAVADSI--PEVLADLGSLESLANSETSDLSLYLVVAVAAVSCIFLVFVIVLL 713

Query: 483 -----KQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARD 537
                + +       ++  + G+P S +V ++   GV   LQ++ +E             
Sbjct: 714 ALRLWRWHKSRLLQASEGGLAGMPTSHFVGVD---GVQAFLQTYSHE------------- 757

Query: 538 SGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDK 597
                      +SL    Q  +   +++P  P  G T +           L+ +  A+  
Sbjct: 758 -----------VSLIADSQKSH---LIFPQ-PNYGDTLISQESCEKSEPLLIAEDSAI-- 800

Query: 598 DSGQNAWLSYRLLKASEPGLFAVGEHTGEQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWP 657
                      +L   +P        + +QAPPNTDWRFSQAQRPGTSGSQNGDDTGTWP
Sbjct: 801 -----------ILGKCDPT-------SNQQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWP 842

Query: 658 NNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPG 717
           NNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPG
Sbjct: 843 NNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPG 902

Query: 718 SNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK 750
           SNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK
Sbjct: 903 SNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK 935



 Score =  153 bits (386), Expect = 6e-37
 Identities = 164/585 (28%), Positives = 248/585 (42%), Gaps = 72/585 (12%)

Query: 70  RGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEII--DI 127
           RG+T   A NP    L+  G +DRE+     +   L   L   D ++   V + ++  D+
Sbjct: 184 RGRTD-GAKNPE---LVLEGSLDREK---EAAHLLLLTALDGGDPIRKGAVPIRVVVLDV 236

Query: 128 NDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVN-----SLQSYQLSPNNYFSLQ 182
           ND+ P F +    + V E+   G R  + NA DPD G+N     S ++ +   +  F L 
Sbjct: 237 NDHIPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLD 296

Query: 183 LRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPM 242
                  ++  E+ + GSLD EK   + + +   DGG       + I VV  DVND+ P 
Sbjct: 297 -------SQTGEVQVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVV--DVNDNAPE 347

Query: 243 FTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTG-- 300
            T +    S+ EN   GT + ++N  D D G NG+V     N        F+L+   G  
Sbjct: 348 ITITSSINSILENSPPGTVIALLNVQDQDSGENGQVSCFIPNHLP-----FKLEKTYGNY 402

Query: 301 -EVQVRGSLDFEKYRFYEMEIQGQDGGG--LFTTTTMLITVVDVNDNAPEITITSSINSI 357
            ++     LD E  + Y + +   D G   L   T + + V D NDN P    +S    I
Sbjct: 403 YKLITSRVLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYI 462

Query: 358 LENSPPGTVIALLNVQDQDSGENGQVSCF--------IPNHLPFKLEKTYGNYYKLITSR 409
            EN+P G  I  +   D DS +N  V+          +P      +    G  Y L   +
Sbjct: 463 PENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYAL---Q 519

Query: 410 VLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPP--VFPH-----SSYSAYI 462
             D E  +   + + A D G PPLS+   + L V D NDN P  ++P      S+     
Sbjct: 520 SFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELA 579

Query: 463 PENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFD 522
           P +   G  +  V A+D DS QNA ++Y L   +  G+      ++  +TG +   ++  
Sbjct: 580 PRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGL-----FAVGEHTGEVRTARALL 634

Query: 523 YEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRS 582
                   L V  +D G PPLS+ V+L++ V    D+ PE+L      +     E +  S
Sbjct: 635 DRDALKQSLVVAVQDHGQPPLSATVTLTVAVA---DSIPEVLADLGSLESLANSETSDLS 691

Query: 583 AEPGYLVTKVVAVD----------KDSGQNAWLSYRLLKASEPGL 617
               YLV  V AV                  W   RLL+ASE GL
Sbjct: 692 L---YLVVAVAAVSCIFLVFVIVLLALRLWRWHKSRLLQASEGGL 733


>gi|8850232 protocadherin gamma subfamily A, 12 isoform 1 precursor
           [Homo sapiens]
          Length = 932

 Score =  865 bits (2236), Expect = 0.0
 Identities = 430/613 (70%), Positives = 510/613 (83%)

Query: 14  LLLLCIFLGTLRGFRARQIRYSVPEETEKGSFVGNISKDLGLEPRELAKRGVRIVSRGKT 73
           L+LL I LGTL      QIRYSVPEE EKGS VG+IS+DLGLEPRELA+RGVRI+ RG+T
Sbjct: 13  LVLLGILLGTLWETGCTQIRYSVPEELEKGSRVGDISRDLGLEPRELAERGVRIIPRGRT 72

Query: 74  QLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEIIDINDNAPS 133
           QLFA+NPRSGSL+TAGRIDREELC     C LN+++L+ED +KIYGVEVE+ DINDNAP 
Sbjct: 73  QLFALNPRSGSLVTAGRIDREELCMGAIKCQLNLDILMEDKVKIYGVEVEVRDINDNAPY 132

Query: 134 FQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGAKNP 193
           F+E E+EIK+SE+A    RF LP+A DPD+G NSLQSY+LSPN +FSL ++   DG+K P
Sbjct: 133 FRESELEIKISENAATEMRFPLPHAWDPDIGKNSLQSYELSPNTHFSLIVQNGADGSKYP 192

Query: 194 ELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVP 253
           ELVL+ +LDRE++AAH L+LTA DGGDP+R G   IRV+VLD ND+ P F Q  YR SVP
Sbjct: 193 ELVLKRALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPEYRASVP 252

Query: 254 ENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGEVQVRGSLDFEKY 313
           EN++ GT++L+VNATDPDEG+N EV YSFR ++ KA+++F+LD  +G +   G LD E+ 
Sbjct: 253 ENLALGTQLLVVNATDPDEGVNAEVRYSFRYVDDKAAQVFKLDCNSGTISTIGELDHEES 312

Query: 314 RFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILENSPPGTVIALLNVQ 373
            FY+ME+Q  D  G      +LITV+DVNDNAPE+ +TS  +S+ ENSP GT+IALLNV 
Sbjct: 313 GFYQMEVQAMDNAGYSARAKVLITVLDVNDNAPEVVLTSLASSVPENSPRGTLIALLNVN 372

Query: 374 DQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDRELVQSYNITLTATDQGSPPL 433
           DQDS ENGQV CFI  +LPFKLEK+YGNYY L+T  VLDRE V SYNIT+TATD+G+PPL
Sbjct: 373 DQDSEENGQVICFIQGNLPFKLEKSYGNYYSLVTDIVLDREQVPSYNITVTATDRGTPPL 432

Query: 434 SAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDSKQNALVTYSLT 493
           S ETH+ LNVAD NDNPPVFP +SYSAYIPENNPRG S+ SVTA DPD ++NA +TYSL 
Sbjct: 433 STETHISLNVADTNDNPPVFPQASYSAYIPENNPRGVSLVSVTAHDPDCEENAQITYSLA 492

Query: 494 DDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFV 553
           ++T+QG  LSSYVSINS+TGVLYAL SFDYEQFRDL+++V+ARD+G PPLSSNVSLSLFV
Sbjct: 493 ENTIQGASLSSYVSINSDTGVLYALSSFDYEQFRDLQVKVMARDNGHPPLSSNVSLSLFV 552

Query: 554 LDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKAS 613
           LDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVD+DSGQNAWLSYRLLKAS
Sbjct: 553 LDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKAS 612

Query: 614 EPGLFAVGEHTGE 626
           EPGLF+VG HTGE
Sbjct: 613 EPGLFSVGLHTGE 625



 Score =  260 bits (665), Expect = 3e-69
 Identities = 125/125 (100%), Positives = 125/125 (100%)

Query: 626 EQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLG 685
           EQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLG
Sbjct: 808 EQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLG 867

Query: 686 GGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSG 745
           GGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSG
Sbjct: 868 GGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSG 927

Query: 746 KKEKK 750
           KKEKK
Sbjct: 928 KKEKK 932



 Score =  150 bits (379), Expect = 4e-36
 Identities = 147/533 (27%), Positives = 221/533 (41%), Gaps = 63/533 (11%)

Query: 120 VEVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQL-----S 174
           + V ++D NDNAP+F + E    V E+   G +  + NA DPD GVN+   Y        
Sbjct: 228 IRVMVLDANDNAPAFAQPEYRASVPENLALGTQLLVVNATDPDEGVNAEVRYSFRYVDDK 287

Query: 175 PNNYFSLQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVL 234
               F L     T       +   G LD E+   + + + A+D      +  V I   VL
Sbjct: 288 AAQVFKLDCNSGT-------ISTIGELDHEESGFYQMEVQAMDNAGYSARAKVLI--TVL 338

Query: 235 DVNDHIPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQ 294
           DVND+ P    +    SVPEN   GT + ++N  D D   NG+V+   +      +  F+
Sbjct: 339 DVNDNAPEVVLTSLASSVPENSPRGTLIALLNVNDQDSEENGQVICFIQG-----NLPFK 393

Query: 295 LDSQTGEVQVRGS---LDFEKYRFYEMEIQGQDGGG--LFTTTTMLITVVDVNDNAPEIT 349
           L+   G      +   LD E+   Y + +   D G   L T T + + V D NDN P   
Sbjct: 394 LEKSYGNYYSLVTDIVLDREQVPSYNITVTATDRGTPPLSTETHISLNVADTNDNPPVFP 453

Query: 350 ITSSINSILENSPPGTVIALLNVQDQDSGENGQVSCFIPNHLP--------FKLEKTYGN 401
             S    I EN+P G  +  +   D D  EN Q++  +  +            +    G 
Sbjct: 454 QASYSAYIPENNPRGVSLVSVTAHDPDCEENAQITYSLAENTIQGASLSSYVSINSDTGV 513

Query: 402 YYKLITSRVLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPP--VFPH---- 455
            Y L +    D E  +   + + A D G PPLS+   + L V D NDN P  ++P     
Sbjct: 514 LYALSS---FDYEQFRDLQVKVMARDNGHPPLSSNVSLSLFVLDQNDNAPEILYPALPTD 570

Query: 456 -SSYSAYIPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGV 514
            S+     P +   G  +  V A+D DS QNA ++Y L   +  G+      S+  +TG 
Sbjct: 571 GSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGL-----FSVGLHTGE 625

Query: 515 LYALQSFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGST 574
           +   ++          L V  +D G PPLS+ V+L++ V    D+ P++L      +   
Sbjct: 626 VRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVA---DSIPQVLADLGSLESPA 682

Query: 575 GVELAPRSAEPGYLVTKVVAVD----------KDSGQNAWLSYRLLKASEPGL 617
             E +  +    YLV  V AV                  W   RLL+AS  GL
Sbjct: 683 NSETSDLTL---YLVVAVAAVSCVFLAFVILLLALRLRRWHKSRLLQASGGGL 732


>gi|14196457 protocadherin gamma subfamily A, 12 isoform 2 precursor
           [Homo sapiens]
          Length = 820

 Score =  865 bits (2236), Expect = 0.0
 Identities = 430/613 (70%), Positives = 510/613 (83%)

Query: 14  LLLLCIFLGTLRGFRARQIRYSVPEETEKGSFVGNISKDLGLEPRELAKRGVRIVSRGKT 73
           L+LL I LGTL      QIRYSVPEE EKGS VG+IS+DLGLEPRELA+RGVRI+ RG+T
Sbjct: 13  LVLLGILLGTLWETGCTQIRYSVPEELEKGSRVGDISRDLGLEPRELAERGVRIIPRGRT 72

Query: 74  QLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEIIDINDNAPS 133
           QLFA+NPRSGSL+TAGRIDREELC     C LN+++L+ED +KIYGVEVE+ DINDNAP 
Sbjct: 73  QLFALNPRSGSLVTAGRIDREELCMGAIKCQLNLDILMEDKVKIYGVEVEVRDINDNAPY 132

Query: 134 FQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGAKNP 193
           F+E E+EIK+SE+A    RF LP+A DPD+G NSLQSY+LSPN +FSL ++   DG+K P
Sbjct: 133 FRESELEIKISENAATEMRFPLPHAWDPDIGKNSLQSYELSPNTHFSLIVQNGADGSKYP 192

Query: 194 ELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVP 253
           ELVL+ +LDRE++AAH L+LTA DGGDP+R G   IRV+VLD ND+ P F Q  YR SVP
Sbjct: 193 ELVLKRALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPEYRASVP 252

Query: 254 ENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGEVQVRGSLDFEKY 313
           EN++ GT++L+VNATDPDEG+N EV YSFR ++ KA+++F+LD  +G +   G LD E+ 
Sbjct: 253 ENLALGTQLLVVNATDPDEGVNAEVRYSFRYVDDKAAQVFKLDCNSGTISTIGELDHEES 312

Query: 314 RFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILENSPPGTVIALLNVQ 373
            FY+ME+Q  D  G      +LITV+DVNDNAPE+ +TS  +S+ ENSP GT+IALLNV 
Sbjct: 313 GFYQMEVQAMDNAGYSARAKVLITVLDVNDNAPEVVLTSLASSVPENSPRGTLIALLNVN 372

Query: 374 DQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDRELVQSYNITLTATDQGSPPL 433
           DQDS ENGQV CFI  +LPFKLEK+YGNYY L+T  VLDRE V SYNIT+TATD+G+PPL
Sbjct: 373 DQDSEENGQVICFIQGNLPFKLEKSYGNYYSLVTDIVLDREQVPSYNITVTATDRGTPPL 432

Query: 434 SAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDSKQNALVTYSLT 493
           S ETH+ LNVAD NDNPPVFP +SYSAYIPENNPRG S+ SVTA DPD ++NA +TYSL 
Sbjct: 433 STETHISLNVADTNDNPPVFPQASYSAYIPENNPRGVSLVSVTAHDPDCEENAQITYSLA 492

Query: 494 DDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFV 553
           ++T+QG  LSSYVSINS+TGVLYAL SFDYEQFRDL+++V+ARD+G PPLSSNVSLSLFV
Sbjct: 493 ENTIQGASLSSYVSINSDTGVLYALSSFDYEQFRDLQVKVMARDNGHPPLSSNVSLSLFV 552

Query: 554 LDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKAS 613
           LDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVD+DSGQNAWLSYRLLKAS
Sbjct: 553 LDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKAS 612

Query: 614 EPGLFAVGEHTGE 626
           EPGLF+VG HTGE
Sbjct: 613 EPGLFSVGLHTGE 625



 Score =  150 bits (379), Expect = 4e-36
 Identities = 147/533 (27%), Positives = 221/533 (41%), Gaps = 63/533 (11%)

Query: 120 VEVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQL-----S 174
           + V ++D NDNAP+F + E    V E+   G +  + NA DPD GVN+   Y        
Sbjct: 228 IRVMVLDANDNAPAFAQPEYRASVPENLALGTQLLVVNATDPDEGVNAEVRYSFRYVDDK 287

Query: 175 PNNYFSLQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVL 234
               F L     T       +   G LD E+   + + + A+D      +  V I   VL
Sbjct: 288 AAQVFKLDCNSGT-------ISTIGELDHEESGFYQMEVQAMDNAGYSARAKVLI--TVL 338

Query: 235 DVNDHIPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQ 294
           DVND+ P    +    SVPEN   GT + ++N  D D   NG+V+   +      +  F+
Sbjct: 339 DVNDNAPEVVLTSLASSVPENSPRGTLIALLNVNDQDSEENGQVICFIQG-----NLPFK 393

Query: 295 LDSQTGEVQVRGS---LDFEKYRFYEMEIQGQDGGG--LFTTTTMLITVVDVNDNAPEIT 349
           L+   G      +   LD E+   Y + +   D G   L T T + + V D NDN P   
Sbjct: 394 LEKSYGNYYSLVTDIVLDREQVPSYNITVTATDRGTPPLSTETHISLNVADTNDNPPVFP 453

Query: 350 ITSSINSILENSPPGTVIALLNVQDQDSGENGQVSCFIPNHLP--------FKLEKTYGN 401
             S    I EN+P G  +  +   D D  EN Q++  +  +            +    G 
Sbjct: 454 QASYSAYIPENNPRGVSLVSVTAHDPDCEENAQITYSLAENTIQGASLSSYVSINSDTGV 513

Query: 402 YYKLITSRVLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPP--VFPH---- 455
            Y L +    D E  +   + + A D G PPLS+   + L V D NDN P  ++P     
Sbjct: 514 LYALSS---FDYEQFRDLQVKVMARDNGHPPLSSNVSLSLFVLDQNDNAPEILYPALPTD 570

Query: 456 -SSYSAYIPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGV 514
            S+     P +   G  +  V A+D DS QNA ++Y L   +  G+      S+  +TG 
Sbjct: 571 GSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGL-----FSVGLHTGE 625

Query: 515 LYALQSFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGST 574
           +   ++          L V  +D G PPLS+ V+L++ V    D+ P++L      +   
Sbjct: 626 VRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVA---DSIPQVLADLGSLESPA 682

Query: 575 GVELAPRSAEPGYLVTKVVAVD----------KDSGQNAWLSYRLLKASEPGL 617
             E +  +    YLV  V AV                  W   RLL+AS  GL
Sbjct: 683 NSETSDLTL---YLVVAVAAVSCVFLAFVILLLALRLRRWHKSRLLQASGGGL 732


>gi|14270484 protocadherin gamma subfamily A, 8 isoform 1 precursor
           [Homo sapiens]
          Length = 932

 Score =  852 bits (2202), Expect = 0.0
 Identities = 431/624 (69%), Positives = 509/624 (81%), Gaps = 4/624 (0%)

Query: 3   NRLQRGDRSRLLLLLCIFLGTLRGFRARQIRYSVPEETEKGSFVGNISKDLGLEPRELAK 62
           +R +RG+    L+LLC  LGTL      QIRYSVPEET+KGSFVGNISKDLGL+PR+LAK
Sbjct: 6   SRPRRGE----LILLCALLGTLWEIGRGQIRYSVPEETDKGSFVGNISKDLGLDPRKLAK 61

Query: 63  RGVRIVSRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEV 122
            GVRIVSRG+TQLFA+NPRSGSLITAGRIDREELC     C +N+  LVED  K++GVE+
Sbjct: 62  HGVRIVSRGRTQLFALNPRSGSLITAGRIDREELCAQSPRCLININTLVEDKGKLFGVEI 121

Query: 123 EIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQ 182
           EIIDINDN P FQ +++E+K++E A+PGAR+ LP A DPDVGVNSLQSYQLSPN++FSL 
Sbjct: 122 EIIDINDNNPKFQVEDLEVKINEIAVPGARYPLPEAVDPDVGVNSLQSYQLSPNHHFSLD 181

Query: 183 LRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPM 242
           ++   +GA NPELVLE +LDRE+EAAH L+LTA DGG P R   V I V VLD ND+ P+
Sbjct: 182 VQTGDNGAINPELVLERALDREEEAAHHLVLTASDGGKPPRSSTVRIHVTVLDTNDNAPV 241

Query: 243 FTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGEV 302
           F   +YRV V EN+  GTR+L V A+DPDEGING+V Y FR +  K + +FQL+  TGE+
Sbjct: 242 FPHPIYRVKVLENMPPGTRLLTVTASDPDEGINGKVAYKFRKINEKQTPLFQLNENTGEI 301

Query: 303 QVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILENSP 362
            +  SLD+E+  FYEMEIQ +D G L   T +LI+V DVNDN PE+ ITS  + +LENS 
Sbjct: 302 SIAKSLDYEECSFYEMEIQAEDVGALLGRTKLLISVEDVNDNRPEVIITSLFSPVLENSL 361

Query: 363 PGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDRELVQSYNIT 422
           PGTVIA L+V DQDSG+NGQV C+  ++LPFKLEK+ GNYY+L+T + LDRE V  YNIT
Sbjct: 362 PGTVIAFLSVHDQDSGKNGQVVCYTRDNLPFKLEKSIGNYYRLVTRKYLDRENVSIYNIT 421

Query: 423 LTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDS 482
           + A+D G+PPLS ET + L+VAD NDNPP FPH+SYSAYI ENN RGASIFS+TA DPDS
Sbjct: 422 VMASDLGTPPLSTETQIALHVADINDNPPTFPHASYSAYILENNLRGASIFSLTAHDPDS 481

Query: 483 KQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPP 542
           ++NA VTYS+T+DT+QG PLSSY+SINS+TGVLYALQSFDYEQ RDL+L V A DSGDPP
Sbjct: 482 QENAQVTYSVTEDTLQGAPLSSYISINSDTGVLYALQSFDYEQIRDLQLLVTASDSGDPP 541

Query: 543 LSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQN 602
           LSSN+SLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAE GYLVTKVVAVD+DSGQN
Sbjct: 542 LSSNMSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAERGYLVTKVVAVDRDSGQN 601

Query: 603 AWLSYRLLKASEPGLFAVGEHTGE 626
           AWLSYRLLKASEPGLF+VG HTGE
Sbjct: 602 AWLSYRLLKASEPGLFSVGLHTGE 625



 Score =  261 bits (668), Expect = 1e-69
 Identities = 125/126 (99%), Positives = 126/126 (100%)

Query: 625 GEQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTL 684
           G+QAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTL
Sbjct: 807 GQQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTL 866

Query: 685 GGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKS 744
           GGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKS
Sbjct: 867 GGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKS 926

Query: 745 GKKEKK 750
           GKKEKK
Sbjct: 927 GKKEKK 932



 Score =  162 bits (411), Expect = 8e-40
 Identities = 176/621 (28%), Positives = 262/621 (42%), Gaps = 69/621 (11%)

Query: 33  RYSVPEETEKGSFVGNISKDLGLEPRELAKRGVRIVSRGKTQLFAVNPRSGSLITAGRID 92
           RY +PE  +    V ++ +   L P       V+    G     A+NP    L+    +D
Sbjct: 151 RYPLPEAVDPDVGVNSL-QSYQLSPNHHFSLDVQTGDNG-----AINPE---LVLERALD 201

Query: 93  REELCETVSSCFLNMELLVEDTLK-----IYGVEVEIIDINDNAPSFQEDEVEIKVSEHA 147
           REE          ++ L   D  K        + V ++D NDNAP F      +KV E+ 
Sbjct: 202 REE------EAAHHLVLTASDGGKPPRSSTVRIHVTVLDTNDNAPVFPHPIYRVKVLENM 255

Query: 148 IPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGAKNPELVLEGSLDREKEA 207
            PG R     A DPD G+N   +Y+    N     L    +     E+ +  SLD E+ +
Sbjct: 256 PPGTRLLTVTASDPDEGINGKVAYKFRKINEKQTPLFQLNENTG--EISIAKSLDYEECS 313

Query: 208 AHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVPENISSGTRVLMVNA 267
            + + + A D G  +  G   + + V DVND+ P    +     V EN   GT +  ++ 
Sbjct: 314 FYEMEIQAEDVGALL--GRTKLLISVEDVNDNRPEVIITSLFSPVLENSLPGTVIAFLSV 371

Query: 268 TDPDEGINGEVM-YSFRNMESKASEIFQLDSQTGE---VQVRGSLDFEKYRFYEMEIQGQ 323
            D D G NG+V+ Y+  N+       F+L+   G    +  R  LD E    Y + +   
Sbjct: 372 HDQDSGKNGQVVCYTRDNLP------FKLEKSIGNYYRLVTRKYLDRENVSIYNITVMAS 425

Query: 324 DGGG--LFTTTTMLITVVDVNDNAPEITITSSINSILENSPPGTVIALLNVQDQDSGENG 381
           D G   L T T + + V D+NDN P     S    ILEN+  G  I  L   D DS EN 
Sbjct: 426 DLGTPPLSTETQIALHVADINDNPPTFPHASYSAYILENNLRGASIFSLTAHDPDSQENA 485

Query: 382 QVSCFI--------PNHLPFKLEKTYGNYYKLITSRVLDRELVQSYNITLTATDQGSPPL 433
           QV+  +        P      +    G  Y L   +  D E ++   + +TA+D G PPL
Sbjct: 486 QVTYSVTEDTLQGAPLSSYISINSDTGVLYAL---QSFDYEQIRDLQLLVTASDSGDPPL 542

Query: 434 SAETHVWLNVADDNDNPP--VFPH-----SSYSAYIPENNPRGASIFSVTALDPDSKQNA 486
           S+   + L V D NDN P  ++P      S+     P +  RG  +  V A+D DS QNA
Sbjct: 543 SSNMSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAERGYLVTKVVAVDRDSGQNA 602

Query: 487 LVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPPLSSN 546
            ++Y L   +  G+      S+  +TG +   ++          L V  +D G PPLS+ 
Sbjct: 603 WLSYRLLKASEPGL-----FSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSAT 657

Query: 547 VSLSLFVLDQNDNAPEI------LYPAL-PTDGSTGVELAPRSAEPGYLVTKVVAVDKDS 599
           V+L++ V    D+ PE+      L P++ P D S  + L    A    +    VAV    
Sbjct: 658 VTLTVAVA---DSIPEVLTELGSLKPSVDPNDSSLTLYLVVAVAAISCVFLAFVAVLLGL 714

Query: 600 GQNAWLSYRLLKASEPGLFAV 620
               W   RLL+ S   L  V
Sbjct: 715 RLRRWHKSRLLQDSGGRLVGV 735


>gi|7662056 protocadherin gamma subfamily A, 8 isoform 2 precursor
           [Homo sapiens]
          Length = 820

 Score =  852 bits (2202), Expect = 0.0
 Identities = 431/624 (69%), Positives = 509/624 (81%), Gaps = 4/624 (0%)

Query: 3   NRLQRGDRSRLLLLLCIFLGTLRGFRARQIRYSVPEETEKGSFVGNISKDLGLEPRELAK 62
           +R +RG+    L+LLC  LGTL      QIRYSVPEET+KGSFVGNISKDLGL+PR+LAK
Sbjct: 6   SRPRRGE----LILLCALLGTLWEIGRGQIRYSVPEETDKGSFVGNISKDLGLDPRKLAK 61

Query: 63  RGVRIVSRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEV 122
            GVRIVSRG+TQLFA+NPRSGSLITAGRIDREELC     C +N+  LVED  K++GVE+
Sbjct: 62  HGVRIVSRGRTQLFALNPRSGSLITAGRIDREELCAQSPRCLININTLVEDKGKLFGVEI 121

Query: 123 EIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQ 182
           EIIDINDN P FQ +++E+K++E A+PGAR+ LP A DPDVGVNSLQSYQLSPN++FSL 
Sbjct: 122 EIIDINDNNPKFQVEDLEVKINEIAVPGARYPLPEAVDPDVGVNSLQSYQLSPNHHFSLD 181

Query: 183 LRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPM 242
           ++   +GA NPELVLE +LDRE+EAAH L+LTA DGG P R   V I V VLD ND+ P+
Sbjct: 182 VQTGDNGAINPELVLERALDREEEAAHHLVLTASDGGKPPRSSTVRIHVTVLDTNDNAPV 241

Query: 243 FTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGEV 302
           F   +YRV V EN+  GTR+L V A+DPDEGING+V Y FR +  K + +FQL+  TGE+
Sbjct: 242 FPHPIYRVKVLENMPPGTRLLTVTASDPDEGINGKVAYKFRKINEKQTPLFQLNENTGEI 301

Query: 303 QVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILENSP 362
            +  SLD+E+  FYEMEIQ +D G L   T +LI+V DVNDN PE+ ITS  + +LENS 
Sbjct: 302 SIAKSLDYEECSFYEMEIQAEDVGALLGRTKLLISVEDVNDNRPEVIITSLFSPVLENSL 361

Query: 363 PGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDRELVQSYNIT 422
           PGTVIA L+V DQDSG+NGQV C+  ++LPFKLEK+ GNYY+L+T + LDRE V  YNIT
Sbjct: 362 PGTVIAFLSVHDQDSGKNGQVVCYTRDNLPFKLEKSIGNYYRLVTRKYLDRENVSIYNIT 421

Query: 423 LTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDS 482
           + A+D G+PPLS ET + L+VAD NDNPP FPH+SYSAYI ENN RGASIFS+TA DPDS
Sbjct: 422 VMASDLGTPPLSTETQIALHVADINDNPPTFPHASYSAYILENNLRGASIFSLTAHDPDS 481

Query: 483 KQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPP 542
           ++NA VTYS+T+DT+QG PLSSY+SINS+TGVLYALQSFDYEQ RDL+L V A DSGDPP
Sbjct: 482 QENAQVTYSVTEDTLQGAPLSSYISINSDTGVLYALQSFDYEQIRDLQLLVTASDSGDPP 541

Query: 543 LSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQN 602
           LSSN+SLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAE GYLVTKVVAVD+DSGQN
Sbjct: 542 LSSNMSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAERGYLVTKVVAVDRDSGQN 601

Query: 603 AWLSYRLLKASEPGLFAVGEHTGE 626
           AWLSYRLLKASEPGLF+VG HTGE
Sbjct: 602 AWLSYRLLKASEPGLFSVGLHTGE 625



 Score =  162 bits (411), Expect = 8e-40
 Identities = 176/621 (28%), Positives = 262/621 (42%), Gaps = 69/621 (11%)

Query: 33  RYSVPEETEKGSFVGNISKDLGLEPRELAKRGVRIVSRGKTQLFAVNPRSGSLITAGRID 92
           RY +PE  +    V ++ +   L P       V+    G     A+NP    L+    +D
Sbjct: 151 RYPLPEAVDPDVGVNSL-QSYQLSPNHHFSLDVQTGDNG-----AINPE---LVLERALD 201

Query: 93  REELCETVSSCFLNMELLVEDTLK-----IYGVEVEIIDINDNAPSFQEDEVEIKVSEHA 147
           REE          ++ L   D  K        + V ++D NDNAP F      +KV E+ 
Sbjct: 202 REE------EAAHHLVLTASDGGKPPRSSTVRIHVTVLDTNDNAPVFPHPIYRVKVLENM 255

Query: 148 IPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGAKNPELVLEGSLDREKEA 207
            PG R     A DPD G+N   +Y+    N     L    +     E+ +  SLD E+ +
Sbjct: 256 PPGTRLLTVTASDPDEGINGKVAYKFRKINEKQTPLFQLNENTG--EISIAKSLDYEECS 313

Query: 208 AHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVPENISSGTRVLMVNA 267
            + + + A D G  +  G   + + V DVND+ P    +     V EN   GT +  ++ 
Sbjct: 314 FYEMEIQAEDVGALL--GRTKLLISVEDVNDNRPEVIITSLFSPVLENSLPGTVIAFLSV 371

Query: 268 TDPDEGINGEVM-YSFRNMESKASEIFQLDSQTGE---VQVRGSLDFEKYRFYEMEIQGQ 323
            D D G NG+V+ Y+  N+       F+L+   G    +  R  LD E    Y + +   
Sbjct: 372 HDQDSGKNGQVVCYTRDNLP------FKLEKSIGNYYRLVTRKYLDRENVSIYNITVMAS 425

Query: 324 DGGG--LFTTTTMLITVVDVNDNAPEITITSSINSILENSPPGTVIALLNVQDQDSGENG 381
           D G   L T T + + V D+NDN P     S    ILEN+  G  I  L   D DS EN 
Sbjct: 426 DLGTPPLSTETQIALHVADINDNPPTFPHASYSAYILENNLRGASIFSLTAHDPDSQENA 485

Query: 382 QVSCFI--------PNHLPFKLEKTYGNYYKLITSRVLDRELVQSYNITLTATDQGSPPL 433
           QV+  +        P      +    G  Y L   +  D E ++   + +TA+D G PPL
Sbjct: 486 QVTYSVTEDTLQGAPLSSYISINSDTGVLYAL---QSFDYEQIRDLQLLVTASDSGDPPL 542

Query: 434 SAETHVWLNVADDNDNPP--VFPH-----SSYSAYIPENNPRGASIFSVTALDPDSKQNA 486
           S+   + L V D NDN P  ++P      S+     P +  RG  +  V A+D DS QNA
Sbjct: 543 SSNMSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAERGYLVTKVVAVDRDSGQNA 602

Query: 487 LVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPPLSSN 546
            ++Y L   +  G+      S+  +TG +   ++          L V  +D G PPLS+ 
Sbjct: 603 WLSYRLLKASEPGL-----FSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSAT 657

Query: 547 VSLSLFVLDQNDNAPEI------LYPAL-PTDGSTGVELAPRSAEPGYLVTKVVAVDKDS 599
           V+L++ V    D+ PE+      L P++ P D S  + L    A    +    VAV    
Sbjct: 658 VTLTVAVA---DSIPEVLTELGSLKPSVDPNDSSLTLYLVVAVAAISCVFLAFVAVLLGL 714

Query: 600 GQNAWLSYRLLKASEPGLFAV 620
               W   RLL+ S   L  V
Sbjct: 715 RLRRWHKSRLLQDSGGRLVGV 735


>gi|14196468 protocadherin gamma subfamily A, 4 isoform 2 precursor
           [Homo sapiens]
          Length = 820

 Score =  849 bits (2194), Expect = 0.0
 Identities = 424/626 (67%), Positives = 502/626 (80%), Gaps = 1/626 (0%)

Query: 1   MANRLQRGDRSRLLLLLCIFLGTLRGFRARQIRYSVPEETEKGSFVGNISKDLGLEPREL 60
           MA    R D +RLL + C+ LG L   RA QI YSV EE E+GS VGNI+KDLGL PREL
Sbjct: 1   MAAPPARPDHTRLLQI-CLLLGVLVEIRAEQILYSVFEEQEEGSVVGNIAKDLGLAPREL 59

Query: 61  AKRGVRIVSRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGV 120
           A+RGVRIVSRG+TQLFA+NPRSG+L+TAGRIDREELC+   +C  N+E+L+EDT+KI  V
Sbjct: 60  AERGVRIVSRGRTQLFALNPRSGTLVTAGRIDREELCDRSPNCVTNLEILLEDTVKILRV 119

Query: 121 EVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFS 180
           EVEIID+NDN PSF  ++ EIKV+E+  PGARF LP A DPDVGVNSLQ YQL+ N YFS
Sbjct: 120 EVEIIDVNDNPPSFGTEQREIKVAENENPGARFPLPEAFDPDVGVNSLQGYQLNSNGYFS 179

Query: 181 LQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHI 240
           L ++   DG K PELVLE +LDRE+EA H L+LTA DGGDP+R G   I ++++D ND+ 
Sbjct: 180 LDVQSGADGIKYPELVLERALDREEEAVHHLVLTAFDGGDPVRSGTARILIILVDTNDNA 239

Query: 241 PMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTG 300
           P+FTQ  Y VSV EN+  GTR+L V ATDPDEG NG+V YSFR +  K S++FQL+S +G
Sbjct: 240 PVFTQPEYHVSVRENVPVGTRLLTVKATDPDEGANGDVTYSFRKVRDKISQLFQLNSLSG 299

Query: 301 EVQVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILEN 360
           ++ + G LD+E   FY+++++  DG GL   + +L+TV+D NDNAPE+T+TS  +S+ E+
Sbjct: 300 DITILGGLDYEDSGFYDIDVEAHDGPGLRARSKVLVTVLDENDNAPEVTVTSLTSSVQES 359

Query: 361 SPPGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDRELVQSYN 420
           S PGTVIAL NV D DSG NG V+C IP++LPF LEKTYGNYY+L+T R LDRE V  YN
Sbjct: 360 SSPGTVIALFNVHDSDSGGNGLVTCSIPDNLPFTLEKTYGNYYRLLTHRTLDREEVSEYN 419

Query: 421 ITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDP 480
           IT+TATDQG+PPLS ETH+ L V D NDNPP FPH+SYSAYIPENNPRGASI S+TA DP
Sbjct: 420 ITVTATDQGTPPLSTETHISLQVMDINDNPPTFPHASYSAYIPENNPRGASILSMTAQDP 479

Query: 481 DSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGD 540
           DS  NA +TYSL +DT QG PLSSYVSINSNTG+LYAL SFDYEQFRDL+L + A DSGD
Sbjct: 480 DSGDNARITYSLAEDTFQGAPLSSYVSINSNTGILYALCSFDYEQFRDLQLLMTASDSGD 539

Query: 541 PPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSG 600
           PPLSSNVSLSLFVLDQNDN PEILYP  PTDGSTGVELAPRSA+ GYLVTKVVAVD+DSG
Sbjct: 540 PPLSSNVSLSLFVLDQNDNVPEILYPTFPTDGSTGVELAPRSADSGYLVTKVVAVDRDSG 599

Query: 601 QNAWLSYRLLKASEPGLFAVGEHTGE 626
           QNAWLSY LLK+SEPGLFAVG HTGE
Sbjct: 600 QNAWLSYSLLKSSEPGLFAVGLHTGE 625



 Score =  159 bits (403), Expect = 7e-39
 Identities = 148/531 (27%), Positives = 237/531 (44%), Gaps = 55/531 (10%)

Query: 63  RGVRIVSRGKTQLFAVNPRSGS-------LITAGRIDREE--LCETVSSCFLNMELLVED 113
           +G ++ S G    F+++ +SG+       L+    +DREE  +   V + F   + +   
Sbjct: 168 QGYQLNSNG---YFSLDVQSGADGIKYPELVLERALDREEEAVHHLVLTAFDGGDPVRSG 224

Query: 114 TLKIYGVEVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQL 173
           T +I    + ++D NDNAP F + E  + V E+   G R     A DPD G N   +Y  
Sbjct: 225 TARIL---IILVDTNDNAPVFTQPEYHVSVRENVPVGTRLLTVKATDPDEGANGDVTYSF 281

Query: 174 SPNNYFSLQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVV 233
                   QL      + + ++ + G LD E    + + + A DG  P  +    + V V
Sbjct: 282 RKVRDKISQLFQLN--SLSGDITILGGLDYEDSGFYDIDVEAHDG--PGLRARSKVLVTV 337

Query: 234 LDVNDHIPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIF 293
           LD ND+ P  T +    SV E+ S GT + + N  D D G NG V  S  +     +  F
Sbjct: 338 LDENDNAPEVTVTSLTSSVQESSSPGTVIALFNVHDSDSGGNGLVTCSIPD-----NLPF 392

Query: 294 QLDSQTGE---VQVRGSLDFEKYRFYEMEIQGQDGGG--LFTTTTMLITVVDVNDNAPEI 348
            L+   G    +    +LD E+   Y + +   D G   L T T + + V+D+NDN P  
Sbjct: 393 TLEKTYGNYYRLLTHRTLDREEVSEYNITVTATDQGTPPLSTETHISLQVMDINDNPPTF 452

Query: 349 TITSSINSILENSPPGTVIALLNVQDQDSGENGQVSCFI--------PNHLPFKLEKTYG 400
              S    I EN+P G  I  +  QD DSG+N +++  +        P      +    G
Sbjct: 453 PHASYSAYIPENNPRGASILSMTAQDPDSGDNARITYSLAEDTFQGAPLSSYVSINSNTG 512

Query: 401 NYYKLITSRVLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSA 460
             Y L +    D E  +   + +TA+D G PPLS+   + L V D NDN P   + ++  
Sbjct: 513 ILYALCS---FDYEQFRDLQLLMTASDSGDPPLSSNVSLSLFVLDQNDNVPEILYPTFPT 569

Query: 461 -------YIPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTG 513
                    P +   G  +  V A+D DS QNA ++YSL   +  G+      ++  +TG
Sbjct: 570 DGSTGVELAPRSADSGYLVTKVVAVDRDSGQNAWLSYSLLKSSEPGL-----FAVGLHTG 624

Query: 514 VLYALQSFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEIL 564
            +   ++          L V+ +D G PPLS+ V+L++ V    D+ P++L
Sbjct: 625 EVRTARALLDRDALKQRLVVVVQDHGQPPLSATVTLTVAVA---DSIPDVL 672


>gi|11056026 protocadherin gamma subfamily A, 4 isoform 1 precursor
           [Homo sapiens]
          Length = 931

 Score =  849 bits (2194), Expect = 0.0
 Identities = 424/626 (67%), Positives = 502/626 (80%), Gaps = 1/626 (0%)

Query: 1   MANRLQRGDRSRLLLLLCIFLGTLRGFRARQIRYSVPEETEKGSFVGNISKDLGLEPREL 60
           MA    R D +RLL + C+ LG L   RA QI YSV EE E+GS VGNI+KDLGL PREL
Sbjct: 1   MAAPPARPDHTRLLQI-CLLLGVLVEIRAEQILYSVFEEQEEGSVVGNIAKDLGLAPREL 59

Query: 61  AKRGVRIVSRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGV 120
           A+RGVRIVSRG+TQLFA+NPRSG+L+TAGRIDREELC+   +C  N+E+L+EDT+KI  V
Sbjct: 60  AERGVRIVSRGRTQLFALNPRSGTLVTAGRIDREELCDRSPNCVTNLEILLEDTVKILRV 119

Query: 121 EVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFS 180
           EVEIID+NDN PSF  ++ EIKV+E+  PGARF LP A DPDVGVNSLQ YQL+ N YFS
Sbjct: 120 EVEIIDVNDNPPSFGTEQREIKVAENENPGARFPLPEAFDPDVGVNSLQGYQLNSNGYFS 179

Query: 181 LQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHI 240
           L ++   DG K PELVLE +LDRE+EA H L+LTA DGGDP+R G   I ++++D ND+ 
Sbjct: 180 LDVQSGADGIKYPELVLERALDREEEAVHHLVLTAFDGGDPVRSGTARILIILVDTNDNA 239

Query: 241 PMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTG 300
           P+FTQ  Y VSV EN+  GTR+L V ATDPDEG NG+V YSFR +  K S++FQL+S +G
Sbjct: 240 PVFTQPEYHVSVRENVPVGTRLLTVKATDPDEGANGDVTYSFRKVRDKISQLFQLNSLSG 299

Query: 301 EVQVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILEN 360
           ++ + G LD+E   FY+++++  DG GL   + +L+TV+D NDNAPE+T+TS  +S+ E+
Sbjct: 300 DITILGGLDYEDSGFYDIDVEAHDGPGLRARSKVLVTVLDENDNAPEVTVTSLTSSVQES 359

Query: 361 SPPGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDRELVQSYN 420
           S PGTVIAL NV D DSG NG V+C IP++LPF LEKTYGNYY+L+T R LDRE V  YN
Sbjct: 360 SSPGTVIALFNVHDSDSGGNGLVTCSIPDNLPFTLEKTYGNYYRLLTHRTLDREEVSEYN 419

Query: 421 ITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDP 480
           IT+TATDQG+PPLS ETH+ L V D NDNPP FPH+SYSAYIPENNPRGASI S+TA DP
Sbjct: 420 ITVTATDQGTPPLSTETHISLQVMDINDNPPTFPHASYSAYIPENNPRGASILSMTAQDP 479

Query: 481 DSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGD 540
           DS  NA +TYSL +DT QG PLSSYVSINSNTG+LYAL SFDYEQFRDL+L + A DSGD
Sbjct: 480 DSGDNARITYSLAEDTFQGAPLSSYVSINSNTGILYALCSFDYEQFRDLQLLMTASDSGD 539

Query: 541 PPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSG 600
           PPLSSNVSLSLFVLDQNDN PEILYP  PTDGSTGVELAPRSA+ GYLVTKVVAVD+DSG
Sbjct: 540 PPLSSNVSLSLFVLDQNDNVPEILYPTFPTDGSTGVELAPRSADSGYLVTKVVAVDRDSG 599

Query: 601 QNAWLSYRLLKASEPGLFAVGEHTGE 626
           QNAWLSY LLK+SEPGLFAVG HTGE
Sbjct: 600 QNAWLSYSLLKSSEPGLFAVGLHTGE 625



 Score =  373 bits (958), Expect = e-103
 Identities = 281/780 (36%), Positives = 392/780 (50%), Gaps = 106/780 (13%)

Query: 7   RGDRSRLLLLLCIFLGTLRGFRARQIRYSVPEETEKGSFVGNISKDLGLEPRELAKRGV- 65
           R   +R+L++L         F   +   SV E    G+ +  +      +P E A   V 
Sbjct: 222 RSGTARILIILVDTNDNAPVFTQPEYHVSVRENVPVGTRLLTVK---ATDPDEGANGDVT 278

Query: 66  ---RIVSRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYG--- 119
              R V    +QLF +N  SG +   G +D E+      S F ++++   D   +     
Sbjct: 279 YSFRKVRDKISQLFQLNSLSGDITILGGLDYED------SGFYDIDVEAHDGPGLRARSK 332

Query: 120 VEVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYF 179
           V V ++D NDNAP      +   V E + PG   AL N  D D G N L +  +  N  F
Sbjct: 333 VLVTVLDENDNAPEVTVTSLTSSVQESSSPGTVIALFNVHDSDSGGNGLVTCSIPDNLPF 392

Query: 180 SLQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDH 239
           +L+   +T G     L+   +LDRE+ + + + +TA D G P       I + V+D+ND+
Sbjct: 393 TLE---KTYG-NYYRLLTHRTLDREEVSEYNITVTATDQGTPPLSTETHISLQVMDINDN 448

Query: 240 IPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRN---MESKASEIFQLD 296
            P F  + Y   +PEN   G  +L + A DPD G N  + YS        +  S    ++
Sbjct: 449 PPTFPHASYSAYIPENNPRGASILSMTAQDPDSGDNARITYSLAEDTFQGAPLSSYVSIN 508

Query: 297 SQTGEVQVRGSLDFEKYRFYEMEIQGQDGGG--LFTTTTMLITVVDVNDNAPEI---TIT 351
           S TG +    S D+E++R  ++ +   D G   L +  ++ + V+D NDN PEI   T  
Sbjct: 509 SNTGILYALCSFDYEQFRDLQLLMTASDSGDPPLSSNVSLSLFVLDQNDNVPEILYPTFP 568

Query: 352 SSINSILENSP----PGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLIT 407
           +  ++ +E +P     G ++  +   D+DSG+N  +S  +       L     +  ++ T
Sbjct: 569 TDGSTGVELAPRSADSGYLVTKVVAVDRDSGQNAWLSYSLLKSSEPGLFAVGLHTGEVRT 628

Query: 408 SR-VLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENN 466
           +R +LDR+ ++   + +   D G PPLSA   + + VAD    P V           + +
Sbjct: 629 ARALLDRDALKQ-RLVVVVQDHGQPPLSATVTLTVAVADSI--PDVLADLGSLKPSADPD 685

Query: 467 PRGASIFSVTALDPDSKQN-ALVTYSLT---------------DDTVQGVPLSSYVSINS 510
             G +++ V A+   S    A VT  L                   + GVP S +V ++ 
Sbjct: 686 DSGLTLYLVVAVAAVSCVFLAFVTVLLALKLRRWHKSRLLHAEGSRLAGVPASHFVGVD- 744

Query: 511 NTGVLYALQSFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPT 570
             GV   LQ++ +E                      VSL+      +     +++     
Sbjct: 745 --GVRAFLQTYSHE----------------------VSLTA-----DSRKSHLIF----- 770

Query: 571 DGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFAVGEHTGEQAPP 630
                       ++P Y  T +     +  +   ++  LL+         G+   +QAPP
Sbjct: 771 ------------SQPSYADTLISRESCEKSEPLLITQDLLETK-------GDPNLQQAPP 811

Query: 631 NTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGT 690
           NTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGT
Sbjct: 812 NTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGT 871

Query: 691 MGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK 750
           MGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK
Sbjct: 872 MGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK 931



 Score =  159 bits (403), Expect = 7e-39
 Identities = 148/531 (27%), Positives = 237/531 (44%), Gaps = 55/531 (10%)

Query: 63  RGVRIVSRGKTQLFAVNPRSGS-------LITAGRIDREE--LCETVSSCFLNMELLVED 113
           +G ++ S G    F+++ +SG+       L+    +DREE  +   V + F   + +   
Sbjct: 168 QGYQLNSNG---YFSLDVQSGADGIKYPELVLERALDREEEAVHHLVLTAFDGGDPVRSG 224

Query: 114 TLKIYGVEVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQL 173
           T +I    + ++D NDNAP F + E  + V E+   G R     A DPD G N   +Y  
Sbjct: 225 TARIL---IILVDTNDNAPVFTQPEYHVSVRENVPVGTRLLTVKATDPDEGANGDVTYSF 281

Query: 174 SPNNYFSLQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVV 233
                   QL      + + ++ + G LD E    + + + A DG  P  +    + V V
Sbjct: 282 RKVRDKISQLFQLN--SLSGDITILGGLDYEDSGFYDIDVEAHDG--PGLRARSKVLVTV 337

Query: 234 LDVNDHIPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIF 293
           LD ND+ P  T +    SV E+ S GT + + N  D D G NG V  S  +     +  F
Sbjct: 338 LDENDNAPEVTVTSLTSSVQESSSPGTVIALFNVHDSDSGGNGLVTCSIPD-----NLPF 392

Query: 294 QLDSQTGE---VQVRGSLDFEKYRFYEMEIQGQDGGG--LFTTTTMLITVVDVNDNAPEI 348
            L+   G    +    +LD E+   Y + +   D G   L T T + + V+D+NDN P  
Sbjct: 393 TLEKTYGNYYRLLTHRTLDREEVSEYNITVTATDQGTPPLSTETHISLQVMDINDNPPTF 452

Query: 349 TITSSINSILENSPPGTVIALLNVQDQDSGENGQVSCFI--------PNHLPFKLEKTYG 400
              S    I EN+P G  I  +  QD DSG+N +++  +        P      +    G
Sbjct: 453 PHASYSAYIPENNPRGASILSMTAQDPDSGDNARITYSLAEDTFQGAPLSSYVSINSNTG 512

Query: 401 NYYKLITSRVLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSA 460
             Y L +    D E  +   + +TA+D G PPLS+   + L V D NDN P   + ++  
Sbjct: 513 ILYALCS---FDYEQFRDLQLLMTASDSGDPPLSSNVSLSLFVLDQNDNVPEILYPTFPT 569

Query: 461 -------YIPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTG 513
                    P +   G  +  V A+D DS QNA ++YSL   +  G+      ++  +TG
Sbjct: 570 DGSTGVELAPRSADSGYLVTKVVAVDRDSGQNAWLSYSLLKSSEPGL-----FAVGLHTG 624

Query: 514 VLYALQSFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEIL 564
            +   ++          L V+ +D G PPLS+ V+L++ V    D+ P++L
Sbjct: 625 EVRTARALLDRDALKQRLVVVVQDHGQPPLSATVTLTVAVA---DSIPDVL 672


>gi|11128041 protocadherin gamma subfamily A, 10 isoform 1 precursor
           [Homo sapiens]
          Length = 936

 Score =  848 bits (2190), Expect = 0.0
 Identities = 424/624 (67%), Positives = 500/624 (80%)

Query: 3   NRLQRGDRSRLLLLLCIFLGTLRGFRARQIRYSVPEETEKGSFVGNISKDLGLEPRELAK 62
           NR +       L+LLC+F G      ARQI YS+PEE EKGSFVGNISKDLGL PRELA+
Sbjct: 6   NRSKESKDCSGLVLLCLFFGIPWEAGARQISYSIPEELEKGSFVGNISKDLGLAPRELAE 65

Query: 63  RGVRIVSRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEV 122
           RGVRIVSRG+TQLF++NPRSGSLITAGRIDREELC   + C ++  +LVED +K++G+E+
Sbjct: 66  RGVRIVSRGRTQLFSLNPRSGSLITAGRIDREELCAQSARCVVSFNILVEDRVKLFGIEI 125

Query: 123 EIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQ 182
           E+ DINDNAP FQ + +++K++E+   G RF LP A DPDVGVNSLQSYQLSPN +FSL+
Sbjct: 126 EVTDINDNAPKFQAENLDVKINENVAAGMRFPLPEAIDPDVGVNSLQSYQLSPNKHFSLR 185

Query: 183 LRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPM 242
           ++ R +G K PELVLE SLDRE+EA H L+LTA DGGDP+R G V + V V D ND+ P+
Sbjct: 186 VQSRANGVKYPELVLEHSLDREEEAIHHLVLTASDGGDPLRSGTVLVSVTVFDANDNAPV 245

Query: 243 FTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGEV 302
           FT   YRVSVPEN+  GT++L V ATD DEG NGEV YSFR +       FQL+  TGE+
Sbjct: 246 FTLPEYRVSVPENLPVGTQLLTVTATDRDEGANGEVTYSFRKLPDTQLLKFQLNKYTGEI 305

Query: 303 QVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILENSP 362
           ++  +LD+E+  FYE+EIQ +DGG    T  +LITV DVNDN+PE+TITS  + + E+SP
Sbjct: 306 KISENLDYEETGFYEIEIQAEDGGAYLATAKVLITVEDVNDNSPELTITSLFSPVTEDSP 365

Query: 363 PGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDRELVQSYNIT 422
            GTV+ALLNV D DS +NGQV+C I  +LPFKLEK+  +YY+L+  R LDRE V SYNIT
Sbjct: 366 LGTVVALLNVHDLDSEQNGQVTCSILAYLPFKLEKSIDSYYRLVIHRALDREQVSSYNIT 425

Query: 423 LTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDS 482
           +TATD GSPPLS E H  L VAD NDNPP F   SY  YIPENN RGASIFSVTALDPDS
Sbjct: 426 VTATDGGSPPLSTEAHFMLQVADINDNPPTFSQVSYFTYIPENNARGASIFSVTALDPDS 485

Query: 483 KQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPP 542
           K+NA + YSL +DT+QGVPLSSY+SINS+TGVLYAL+SFDYEQF +L+++V A DSGDPP
Sbjct: 486 KENAQIIYSLAEDTIQGVPLSSYISINSDTGVLYALRSFDYEQFHELQMQVTASDSGDPP 545

Query: 543 LSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQN 602
           LSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVD+DSGQN
Sbjct: 546 LSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQN 605

Query: 603 AWLSYRLLKASEPGLFAVGEHTGE 626
           AWLSYRLLKASEPGLFAVGEHTGE
Sbjct: 606 AWLSYRLLKASEPGLFAVGEHTGE 629



 Score =  258 bits (660), Expect = 1e-68
 Identities = 124/124 (100%), Positives = 124/124 (100%)

Query: 627 QAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGG 686
           QAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGG
Sbjct: 813 QAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGG 872

Query: 687 GAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGK 746
           GAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGK
Sbjct: 873 GAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGK 932

Query: 747 KEKK 750
           KEKK
Sbjct: 933 KEKK 936



 Score =  149 bits (376), Expect = 9e-36
 Identities = 152/544 (27%), Positives = 224/544 (41%), Gaps = 72/544 (13%)

Query: 120 VEVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSY---QLSPN 176
           V V + D NDNAP F   E  + V E+   G +     A D D G N   +Y   +L   
Sbjct: 232 VSVTVFDANDNAPVFTLPEYRVSVPENLPVGTQLLTVTATDRDEGANGEVTYSFRKLPDT 291

Query: 177 NYFSLQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDV 236
                QL   T      E+ +  +LD E+   + + + A DGG  +      + + V DV
Sbjct: 292 QLLKFQLNKYTG-----EIKISENLDYEETGFYEIEIQAEDGGAYL--ATAKVLITVEDV 344

Query: 237 NDHIPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFR-----NMESKASE 291
           ND+ P  T +     V E+   GT V ++N  D D   NG+V  S        +E     
Sbjct: 345 NDNSPELTITSLFSPVTEDSPLGTVVALLNVHDLDSEQNGQVTCSILAYLPFKLEKSIDS 404

Query: 292 IFQLDSQTGEVQVRGSLDFEKYRFYEMEIQGQDGGG--LFTTTTMLITVVDVNDNAPEIT 349
            ++L        +  +LD E+   Y + +   DGG   L T    ++ V D+NDN P  +
Sbjct: 405 YYRL-------VIHRALDREQVSSYNITVTATDGGSPPLSTEAHFMLQVADINDNPPTFS 457

Query: 350 ITSSINSILENSPPGTVIALLNVQDQDSGENGQVSCF--------IPNHLPFKLEKTYGN 401
             S    I EN+  G  I  +   D DS EN Q+           +P      +    G 
Sbjct: 458 QVSYFTYIPENNARGASIFSVTALDPDSKENAQIIYSLAEDTIQGVPLSSYISINSDTGV 517

Query: 402 YYKLITSRVLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPP--VFPH---- 455
            Y L   R  D E      + +TA+D G PPLS+   + L V D NDN P  ++P     
Sbjct: 518 LYAL---RSFDYEQFHELQMQVTASDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTD 574

Query: 456 -SSYSAYIPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGV 514
            S+     P +   G  +  V A+D DS QNA ++Y L   +  G+      ++  +TG 
Sbjct: 575 GSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGL-----FAVGEHTGE 629

Query: 515 LYALQSFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGST 574
           +   ++          L V  +D G PPLS+ V+L++ V    D+ P++L          
Sbjct: 630 VRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVA---DSIPQVL-------ADL 679

Query: 575 GVELAPRSAEPG----YLVTKVVAVD----------KDSGQNAWLSYRLLKASEPGLFAV 620
           G   +P ++E      YLV  V AV                  W   RLL+AS  GL  V
Sbjct: 680 GSFESPANSETSDLTLYLVVAVAAVSCVFLAFVIVLLAHRLRRWHKSRLLQASGGGLTGV 739

Query: 621 -GEH 623
            G H
Sbjct: 740 SGSH 743


>gi|14196448 protocadherin gamma subfamily A, 10 isoform 2 precursor
           [Homo sapiens]
          Length = 850

 Score =  848 bits (2190), Expect = 0.0
 Identities = 424/624 (67%), Positives = 500/624 (80%)

Query: 3   NRLQRGDRSRLLLLLCIFLGTLRGFRARQIRYSVPEETEKGSFVGNISKDLGLEPRELAK 62
           NR +       L+LLC+F G      ARQI YS+PEE EKGSFVGNISKDLGL PRELA+
Sbjct: 6   NRSKESKDCSGLVLLCLFFGIPWEAGARQISYSIPEELEKGSFVGNISKDLGLAPRELAE 65

Query: 63  RGVRIVSRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEV 122
           RGVRIVSRG+TQLF++NPRSGSLITAGRIDREELC   + C ++  +LVED +K++G+E+
Sbjct: 66  RGVRIVSRGRTQLFSLNPRSGSLITAGRIDREELCAQSARCVVSFNILVEDRVKLFGIEI 125

Query: 123 EIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQ 182
           E+ DINDNAP FQ + +++K++E+   G RF LP A DPDVGVNSLQSYQLSPN +FSL+
Sbjct: 126 EVTDINDNAPKFQAENLDVKINENVAAGMRFPLPEAIDPDVGVNSLQSYQLSPNKHFSLR 185

Query: 183 LRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPM 242
           ++ R +G K PELVLE SLDRE+EA H L+LTA DGGDP+R G V + V V D ND+ P+
Sbjct: 186 VQSRANGVKYPELVLEHSLDREEEAIHHLVLTASDGGDPLRSGTVLVSVTVFDANDNAPV 245

Query: 243 FTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGEV 302
           FT   YRVSVPEN+  GT++L V ATD DEG NGEV YSFR +       FQL+  TGE+
Sbjct: 246 FTLPEYRVSVPENLPVGTQLLTVTATDRDEGANGEVTYSFRKLPDTQLLKFQLNKYTGEI 305

Query: 303 QVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILENSP 362
           ++  +LD+E+  FYE+EIQ +DGG    T  +LITV DVNDN+PE+TITS  + + E+SP
Sbjct: 306 KISENLDYEETGFYEIEIQAEDGGAYLATAKVLITVEDVNDNSPELTITSLFSPVTEDSP 365

Query: 363 PGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDRELVQSYNIT 422
            GTV+ALLNV D DS +NGQV+C I  +LPFKLEK+  +YY+L+  R LDRE V SYNIT
Sbjct: 366 LGTVVALLNVHDLDSEQNGQVTCSILAYLPFKLEKSIDSYYRLVIHRALDREQVSSYNIT 425

Query: 423 LTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDS 482
           +TATD GSPPLS E H  L VAD NDNPP F   SY  YIPENN RGASIFSVTALDPDS
Sbjct: 426 VTATDGGSPPLSTEAHFMLQVADINDNPPTFSQVSYFTYIPENNARGASIFSVTALDPDS 485

Query: 483 KQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPP 542
           K+NA + YSL +DT+QGVPLSSY+SINS+TGVLYAL+SFDYEQF +L+++V A DSGDPP
Sbjct: 486 KENAQIIYSLAEDTIQGVPLSSYISINSDTGVLYALRSFDYEQFHELQMQVTASDSGDPP 545

Query: 543 LSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQN 602
           LSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVD+DSGQN
Sbjct: 546 LSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQN 605

Query: 603 AWLSYRLLKASEPGLFAVGEHTGE 626
           AWLSYRLLKASEPGLFAVGEHTGE
Sbjct: 606 AWLSYRLLKASEPGLFAVGEHTGE 629



 Score =  149 bits (376), Expect = 9e-36
 Identities = 152/544 (27%), Positives = 224/544 (41%), Gaps = 72/544 (13%)

Query: 120 VEVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSY---QLSPN 176
           V V + D NDNAP F   E  + V E+   G +     A D D G N   +Y   +L   
Sbjct: 232 VSVTVFDANDNAPVFTLPEYRVSVPENLPVGTQLLTVTATDRDEGANGEVTYSFRKLPDT 291

Query: 177 NYFSLQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDV 236
                QL   T      E+ +  +LD E+   + + + A DGG  +      + + V DV
Sbjct: 292 QLLKFQLNKYTG-----EIKISENLDYEETGFYEIEIQAEDGGAYL--ATAKVLITVEDV 344

Query: 237 NDHIPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFR-----NMESKASE 291
           ND+ P  T +     V E+   GT V ++N  D D   NG+V  S        +E     
Sbjct: 345 NDNSPELTITSLFSPVTEDSPLGTVVALLNVHDLDSEQNGQVTCSILAYLPFKLEKSIDS 404

Query: 292 IFQLDSQTGEVQVRGSLDFEKYRFYEMEIQGQDGGG--LFTTTTMLITVVDVNDNAPEIT 349
            ++L        +  +LD E+   Y + +   DGG   L T    ++ V D+NDN P  +
Sbjct: 405 YYRL-------VIHRALDREQVSSYNITVTATDGGSPPLSTEAHFMLQVADINDNPPTFS 457

Query: 350 ITSSINSILENSPPGTVIALLNVQDQDSGENGQVSCF--------IPNHLPFKLEKTYGN 401
             S    I EN+  G  I  +   D DS EN Q+           +P      +    G 
Sbjct: 458 QVSYFTYIPENNARGASIFSVTALDPDSKENAQIIYSLAEDTIQGVPLSSYISINSDTGV 517

Query: 402 YYKLITSRVLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPP--VFPH---- 455
            Y L   R  D E      + +TA+D G PPLS+   + L V D NDN P  ++P     
Sbjct: 518 LYAL---RSFDYEQFHELQMQVTASDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTD 574

Query: 456 -SSYSAYIPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGV 514
            S+     P +   G  +  V A+D DS QNA ++Y L   +  G+      ++  +TG 
Sbjct: 575 GSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGL-----FAVGEHTGE 629

Query: 515 LYALQSFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGST 574
           +   ++          L V  +D G PPLS+ V+L++ V    D+ P++L          
Sbjct: 630 VRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVA---DSIPQVL-------ADL 679

Query: 575 GVELAPRSAEPG----YLVTKVVAVD----------KDSGQNAWLSYRLLKASEPGLFAV 620
           G   +P ++E      YLV  V AV                  W   RLL+AS  GL  V
Sbjct: 680 GSFESPANSETSDLTLYLVVAVAAVSCVFLAFVIVLLAHRLRRWHKSRLLQASGGGLTGV 739

Query: 621 -GEH 623
            G H
Sbjct: 740 SGSH 743


>gi|14196471 protocadherin gamma subfamily A, 5 isoform 2 precursor
           [Homo sapiens]
          Length = 813

 Score =  843 bits (2178), Expect = 0.0
 Identities = 431/613 (70%), Positives = 493/613 (80%)

Query: 14  LLLLCIFLGTLRGFRARQIRYSVPEETEKGSFVGNISKDLGLEPRELAKRGVRIVSRGKT 73
           LLL  + LGTL    + QIRYS+PEE +KGSFVGNI+KDLGLEP+ELA+RGVRIVSRG+T
Sbjct: 13  LLLPFMLLGTLCEPGSGQIRYSMPEELDKGSFVGNIAKDLGLEPQELAERGVRIVSRGRT 72

Query: 74  QLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEIIDINDNAPS 133
           QLFA+NPRSGSL+TAGRIDREELC     C +N  +LVE+ +KIYGVEVEIIDINDN P 
Sbjct: 73  QLFALNPRSGSLVTAGRIDREELCAQSPLCVVNFNILVENKMKIYGVEVEIIDINDNFPR 132

Query: 134 FQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGAKNP 193
           F+++E+++KV+E+A  G R  LP ARD DVGVNSL+SYQLS N +FSL +   TDG K P
Sbjct: 133 FRDEELKVKVNENAAAGTRLVLPFARDADVGVNSLRSYQLSSNLHFSLDVVSGTDGQKYP 192

Query: 194 ELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVP 253
           ELVLE  LDREKE  H LLLTALDGGDP+  G   IRV VLD ND+ P+FT S Y VSVP
Sbjct: 193 ELVLEQPLDREKETVHDLLLTALDGGDPVLSGTTHIRVTVLDANDNAPLFTPSEYSVSVP 252

Query: 254 ENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGEVQVRGSLDFEKY 313
           ENI  GTR+LM+ ATDPDEGING++ YSFRN E K SE FQLDS  GE+    SLD+E+ 
Sbjct: 253 ENIPVGTRLLMLTATDPDEGINGKLTYSFRNEEEKISETFQLDSNLGEISTLQSLDYEES 312

Query: 314 RFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILENSPPGTVIALLNVQ 373
           RFY ME+  QDGG L  +  +++TV DVNDNAPE+ +TS  +SI E+  PGTVIAL +V 
Sbjct: 313 RFYLMEVVAQDGGALVASAKVVVTVQDVNDNAPEVILTSLTSSISEDCLPGTVIALFSVH 372

Query: 374 DQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDRELVQSYNITLTATDQGSPPL 433
           D DSGENG+++C IP +LPFKLEK+  NYY L+T+R LDRE    YNITLT  D G+PPL
Sbjct: 373 DGDSGENGEIACSIPRNLPFKLEKSVDNYYHLLTTRDLDREETSDYNITLTVMDHGTPPL 432

Query: 434 SAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDSKQNALVTYSLT 493
           S E+H+ L VAD NDNPP FP +SYS  + ENNPRG SIFSVTA DPDS  NA VTYSL 
Sbjct: 433 STESHIPLKVADVNDNPPNFPQASYSTSVTENNPRGVSIFSVTAHDPDSGDNARVTYSLA 492

Query: 494 DDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFV 553
           +DT QG PLSSYVSINS+TGVLYAL+SFDYEQ RDL+L V A DSG+PPLSSNVSLSLFV
Sbjct: 493 EDTFQGAPLSSYVSINSDTGVLYALRSFDYEQLRDLQLWVTASDSGNPPLSSNVSLSLFV 552

Query: 554 LDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKAS 613
           LDQNDN PEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKAS
Sbjct: 553 LDQNDNTPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKAS 612

Query: 614 EPGLFAVGEHTGE 626
           EPGLFAVG HTGE
Sbjct: 613 EPGLFAVGLHTGE 625



 Score =  158 bits (400), Expect = 2e-38
 Identities = 145/495 (29%), Positives = 221/495 (44%), Gaps = 41/495 (8%)

Query: 120 VEVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYF 179
           + V ++D NDNAP F   E  + V E+   G R  +  A DPD G+N   +Y    N   
Sbjct: 228 IRVTVLDANDNAPLFTPSEYSVSVPENIPVGTRLLMLTATDPDEGINGKLTYSFR-NEEE 286

Query: 180 SLQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDH 239
            +    + D        L+ SLD E+   +L+ + A DGG  +    V   V V DVND+
Sbjct: 287 KISETFQLDSNLGEISTLQ-SLDYEESRFYLMEVVAQDGGALVASAKVV--VTVQDVNDN 343

Query: 240 IPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSF-RNMESKASEIFQLDSQ 298
            P    +    S+ E+   GT + + +  D D G NGE+  S  RN+  K  +   +D+ 
Sbjct: 344 APEVILTSLTSSISEDCLPGTVIALFSVHDGDSGENGEIACSIPRNLPFKLEK--SVDNY 401

Query: 299 TGEVQVRGSLDFEKYRFYEMEIQGQDGGG--LFTTTTMLITVVDVNDNAPEITITSSINS 356
              +  R  LD E+   Y + +   D G   L T + + + V DVNDN P     S   S
Sbjct: 402 YHLLTTR-DLDREETSDYNITLTVMDHGTPPLSTESHIPLKVADVNDNPPNFPQASYSTS 460

Query: 357 ILENSPPGTVIALLNVQDQDSGENGQVSCFI--------PNHLPFKLEKTYGNYYKLITS 408
           + EN+P G  I  +   D DSG+N +V+  +        P      +    G  Y L   
Sbjct: 461 VTENNPRGVSIFSVTAHDPDSGDNARVTYSLAEDTFQGAPLSSYVSINSDTGVLYAL--- 517

Query: 409 RVLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPP--VFPH-----SSYSAY 461
           R  D E ++   + +TA+D G+PPLS+   + L V D NDN P  ++P      S+    
Sbjct: 518 RSFDYEQLRDLQLWVTASDSGNPPLSSNVSLSLFVLDQNDNTPEILYPALPTDGSTGVEL 577

Query: 462 IPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSF 521
            P +   G  +  V A+D DS QNA ++Y L   +  G+      ++  +TG +   ++ 
Sbjct: 578 APRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGL-----FAVGLHTGEVRTARAL 632

Query: 522 DYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPR 581
                    L V   D G PPLS+  ++++ V D+    P+IL       GS    + P 
Sbjct: 633 LDRDALKQSLVVAVEDHGQPPLSATFTVTVAVADR---IPDILADL----GSIKTPIDPE 685

Query: 582 SAE-PGYLVTKVVAV 595
             +   YLV  V AV
Sbjct: 686 DLDLTLYLVVAVAAV 700



 Score =  133 bits (334), Expect = 7e-31
 Identities = 112/389 (28%), Positives = 180/389 (46%), Gaps = 27/389 (6%)

Query: 73  TQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYG---VEVEIIDIND 129
           ++ F ++   G + T   +D EE      S F  ME++ +D   +     V V + D+ND
Sbjct: 289 SETFQLDSNLGEISTLQSLDYEE------SRFYLMEVVAQDGGALVASAKVVVTVQDVND 342

Query: 130 NAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDG 189
           NAP      +   +SE  +PG   AL +  D D G N   +  +  N  F L+     D 
Sbjct: 343 NAPEVILTSLTSSISEDCLPGTVIALFSVHDGDSGENGEIACSIPRNLPFKLEKS--VDN 400

Query: 190 AKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYR 249
             +  L+    LDRE+ + + + LT +D G P       I + V DVND+ P F Q+ Y 
Sbjct: 401 YYH--LLTTRDLDREETSDYNITLTVMDHGTPPLSTESHIPLKVADVNDNPPNFPQASYS 458

Query: 250 VSVPENISSGTRVLMVNATDPDEGINGEVMYSFRN---MESKASEIFQLDSQTGEVQVRG 306
            SV EN   G  +  V A DPD G N  V YS        +  S    ++S TG +    
Sbjct: 459 TSVTENNPRGVSIFSVTAHDPDSGDNARVTYSLAEDTFQGAPLSSYVSINSDTGVLYALR 518

Query: 307 SLDFEKYRFYEMEIQGQDGGG--LFTTTTMLITVVDVNDNAPEITI-------TSSINSI 357
           S D+E+ R  ++ +   D G   L +  ++ + V+D NDN PEI         ++ +   
Sbjct: 519 SFDYEQLRDLQLWVTASDSGNPPLSSNVSLSLFVLDQNDNTPEILYPALPTDGSTGVELA 578

Query: 358 LENSPPGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSR-VLDRELV 416
             ++ PG ++  +   D+DSG+N  +S  +       L     +  ++ T+R +LDR+ +
Sbjct: 579 PRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFAVGLHTGEVRTARALLDRDAL 638

Query: 417 QSYNITLTATDQGSPPLSAETHVWLNVAD 445
           +  ++ +   D G PPLSA   V + VAD
Sbjct: 639 KQ-SLVVAVEDHGQPPLSATFTVTVAVAD 666


>gi|11056024 protocadherin gamma subfamily A, 5 isoform 1 precursor
           [Homo sapiens]
          Length = 931

 Score =  843 bits (2178), Expect = 0.0
 Identities = 431/613 (70%), Positives = 493/613 (80%)

Query: 14  LLLLCIFLGTLRGFRARQIRYSVPEETEKGSFVGNISKDLGLEPRELAKRGVRIVSRGKT 73
           LLL  + LGTL    + QIRYS+PEE +KGSFVGNI+KDLGLEP+ELA+RGVRIVSRG+T
Sbjct: 13  LLLPFMLLGTLCEPGSGQIRYSMPEELDKGSFVGNIAKDLGLEPQELAERGVRIVSRGRT 72

Query: 74  QLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEIIDINDNAPS 133
           QLFA+NPRSGSL+TAGRIDREELC     C +N  +LVE+ +KIYGVEVEIIDINDN P 
Sbjct: 73  QLFALNPRSGSLVTAGRIDREELCAQSPLCVVNFNILVENKMKIYGVEVEIIDINDNFPR 132

Query: 134 FQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGAKNP 193
           F+++E+++KV+E+A  G R  LP ARD DVGVNSL+SYQLS N +FSL +   TDG K P
Sbjct: 133 FRDEELKVKVNENAAAGTRLVLPFARDADVGVNSLRSYQLSSNLHFSLDVVSGTDGQKYP 192

Query: 194 ELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVP 253
           ELVLE  LDREKE  H LLLTALDGGDP+  G   IRV VLD ND+ P+FT S Y VSVP
Sbjct: 193 ELVLEQPLDREKETVHDLLLTALDGGDPVLSGTTHIRVTVLDANDNAPLFTPSEYSVSVP 252

Query: 254 ENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGEVQVRGSLDFEKY 313
           ENI  GTR+LM+ ATDPDEGING++ YSFRN E K SE FQLDS  GE+    SLD+E+ 
Sbjct: 253 ENIPVGTRLLMLTATDPDEGINGKLTYSFRNEEEKISETFQLDSNLGEISTLQSLDYEES 312

Query: 314 RFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILENSPPGTVIALLNVQ 373
           RFY ME+  QDGG L  +  +++TV DVNDNAPE+ +TS  +SI E+  PGTVIAL +V 
Sbjct: 313 RFYLMEVVAQDGGALVASAKVVVTVQDVNDNAPEVILTSLTSSISEDCLPGTVIALFSVH 372

Query: 374 DQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDRELVQSYNITLTATDQGSPPL 433
           D DSGENG+++C IP +LPFKLEK+  NYY L+T+R LDRE    YNITLT  D G+PPL
Sbjct: 373 DGDSGENGEIACSIPRNLPFKLEKSVDNYYHLLTTRDLDREETSDYNITLTVMDHGTPPL 432

Query: 434 SAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDSKQNALVTYSLT 493
           S E+H+ L VAD NDNPP FP +SYS  + ENNPRG SIFSVTA DPDS  NA VTYSL 
Sbjct: 433 STESHIPLKVADVNDNPPNFPQASYSTSVTENNPRGVSIFSVTAHDPDSGDNARVTYSLA 492

Query: 494 DDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFV 553
           +DT QG PLSSYVSINS+TGVLYAL+SFDYEQ RDL+L V A DSG+PPLSSNVSLSLFV
Sbjct: 493 EDTFQGAPLSSYVSINSDTGVLYALRSFDYEQLRDLQLWVTASDSGNPPLSSNVSLSLFV 552

Query: 554 LDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKAS 613
           LDQNDN PEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKAS
Sbjct: 553 LDQNDNTPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKAS 612

Query: 614 EPGLFAVGEHTGE 626
           EPGLFAVG HTGE
Sbjct: 613 EPGLFAVGLHTGE 625



 Score =  259 bits (663), Expect = 5e-69
 Identities = 125/129 (96%), Positives = 126/129 (97%)

Query: 622 EHTGEQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGS 681
           E   +QAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGS
Sbjct: 803 ERRVQQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGS 862

Query: 682 STLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNK 741
           STLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNK
Sbjct: 863 STLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNK 922

Query: 742 KKSGKKEKK 750
           KKSGKKEKK
Sbjct: 923 KKSGKKEKK 931



 Score =  158 bits (400), Expect = 2e-38
 Identities = 145/495 (29%), Positives = 221/495 (44%), Gaps = 41/495 (8%)

Query: 120 VEVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYF 179
           + V ++D NDNAP F   E  + V E+   G R  +  A DPD G+N   +Y    N   
Sbjct: 228 IRVTVLDANDNAPLFTPSEYSVSVPENIPVGTRLLMLTATDPDEGINGKLTYSFR-NEEE 286

Query: 180 SLQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDH 239
            +    + D        L+ SLD E+   +L+ + A DGG  +    V   V V DVND+
Sbjct: 287 KISETFQLDSNLGEISTLQ-SLDYEESRFYLMEVVAQDGGALVASAKVV--VTVQDVNDN 343

Query: 240 IPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSF-RNMESKASEIFQLDSQ 298
            P    +    S+ E+   GT + + +  D D G NGE+  S  RN+  K  +   +D+ 
Sbjct: 344 APEVILTSLTSSISEDCLPGTVIALFSVHDGDSGENGEIACSIPRNLPFKLEK--SVDNY 401

Query: 299 TGEVQVRGSLDFEKYRFYEMEIQGQDGGG--LFTTTTMLITVVDVNDNAPEITITSSINS 356
              +  R  LD E+   Y + +   D G   L T + + + V DVNDN P     S   S
Sbjct: 402 YHLLTTR-DLDREETSDYNITLTVMDHGTPPLSTESHIPLKVADVNDNPPNFPQASYSTS 460

Query: 357 ILENSPPGTVIALLNVQDQDSGENGQVSCFI--------PNHLPFKLEKTYGNYYKLITS 408
           + EN+P G  I  +   D DSG+N +V+  +        P      +    G  Y L   
Sbjct: 461 VTENNPRGVSIFSVTAHDPDSGDNARVTYSLAEDTFQGAPLSSYVSINSDTGVLYAL--- 517

Query: 409 RVLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPP--VFPH-----SSYSAY 461
           R  D E ++   + +TA+D G+PPLS+   + L V D NDN P  ++P      S+    
Sbjct: 518 RSFDYEQLRDLQLWVTASDSGNPPLSSNVSLSLFVLDQNDNTPEILYPALPTDGSTGVEL 577

Query: 462 IPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSF 521
            P +   G  +  V A+D DS QNA ++Y L   +  G+      ++  +TG +   ++ 
Sbjct: 578 APRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGL-----FAVGLHTGEVRTARAL 632

Query: 522 DYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPR 581
                    L V   D G PPLS+  ++++ V D+    P+IL       GS    + P 
Sbjct: 633 LDRDALKQSLVVAVEDHGQPPLSATFTVTVAVADR---IPDILADL----GSIKTPIDPE 685

Query: 582 SAE-PGYLVTKVVAV 595
             +   YLV  V AV
Sbjct: 686 DLDLTLYLVVAVAAV 700



 Score =  133 bits (334), Expect = 7e-31
 Identities = 112/389 (28%), Positives = 180/389 (46%), Gaps = 27/389 (6%)

Query: 73  TQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYG---VEVEIIDIND 129
           ++ F ++   G + T   +D EE      S F  ME++ +D   +     V V + D+ND
Sbjct: 289 SETFQLDSNLGEISTLQSLDYEE------SRFYLMEVVAQDGGALVASAKVVVTVQDVND 342

Query: 130 NAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDG 189
           NAP      +   +SE  +PG   AL +  D D G N   +  +  N  F L+     D 
Sbjct: 343 NAPEVILTSLTSSISEDCLPGTVIALFSVHDGDSGENGEIACSIPRNLPFKLEKS--VDN 400

Query: 190 AKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYR 249
             +  L+    LDRE+ + + + LT +D G P       I + V DVND+ P F Q+ Y 
Sbjct: 401 YYH--LLTTRDLDREETSDYNITLTVMDHGTPPLSTESHIPLKVADVNDNPPNFPQASYS 458

Query: 250 VSVPENISSGTRVLMVNATDPDEGINGEVMYSFRN---MESKASEIFQLDSQTGEVQVRG 306
            SV EN   G  +  V A DPD G N  V YS        +  S    ++S TG +    
Sbjct: 459 TSVTENNPRGVSIFSVTAHDPDSGDNARVTYSLAEDTFQGAPLSSYVSINSDTGVLYALR 518

Query: 307 SLDFEKYRFYEMEIQGQDGGG--LFTTTTMLITVVDVNDNAPEITI-------TSSINSI 357
           S D+E+ R  ++ +   D G   L +  ++ + V+D NDN PEI         ++ +   
Sbjct: 519 SFDYEQLRDLQLWVTASDSGNPPLSSNVSLSLFVLDQNDNTPEILYPALPTDGSTGVELA 578

Query: 358 LENSPPGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSR-VLDRELV 416
             ++ PG ++  +   D+DSG+N  +S  +       L     +  ++ T+R +LDR+ +
Sbjct: 579 PRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFAVGLHTGEVRTARALLDRDAL 638

Query: 417 QSYNITLTATDQGSPPLSAETHVWLNVAD 445
           +  ++ +   D G PPLSA   V + VAD
Sbjct: 639 KQ-SLVVAVEDHGQPPLSATFTVTVAVAD 666


>gi|11056032 protocadherin gamma subfamily A, 1 isoform 1 precursor
           [Homo sapiens]
          Length = 931

 Score =  834 bits (2155), Expect = 0.0
 Identities = 411/613 (67%), Positives = 496/613 (80%)

Query: 14  LLLLCIFLGTLRGFRARQIRYSVPEETEKGSFVGNISKDLGLEPRELAKRGVRIVSRGKT 73
           L+LLC+ L  L    A  I YSVPEET+KGSFVGNI+KDLGL+P+ELA  GVRIVSRG+ 
Sbjct: 13  LMLLCLSLELLLEAGAGNIHYSVPEETDKGSFVGNIAKDLGLQPQELADGGVRIVSRGRM 72

Query: 74  QLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEIIDINDNAPS 133
            LFA+NPRSGSLITA RIDREELC     C ++  +LVED +K++ VEVEIIDINDN P 
Sbjct: 73  PLFALNPRSGSLITARRIDREELCAQSMPCLVSFNILVEDKMKLFPVEVEIIDINDNTPQ 132

Query: 134 FQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGAKNP 193
           FQ +E+E K++E   PG R +LP  +D DVG+NSLQSYQLS N +FSL ++   DG ++P
Sbjct: 133 FQLEELEFKMNEITTPGTRVSLPFGQDLDVGMNSLQSYQLSSNPHFSLDVQQGADGPQHP 192

Query: 194 ELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVP 253
           E+VL+  LDRE+EA H L+LTA DGG+P+R G + I + V+D ND+ P FTQ+ Y ++VP
Sbjct: 193 EMVLQSPLDREEEAVHHLILTASDGGEPVRSGTLRIYIQVVDANDNPPAFTQAQYHINVP 252

Query: 254 ENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGEVQVRGSLDFEKY 313
           EN+  GT++LMVNATDPDEG NGEV YSF N++ + ++IF+LDS TGE+  +  LDFE+Y
Sbjct: 253 ENVPLGTQLLMVNATDPDEGANGEVTYSFHNVDHRVAQIFRLDSYTGEISNKEPLDFEEY 312

Query: 314 RFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILENSPPGTVIALLNVQ 373
           + Y ME+Q QDG GL     +LI V+DVNDNAPE+TITS   ++ EN PPGT+IAL++V 
Sbjct: 313 KMYSMEVQAQDGAGLMAKVKVLIKVLDVNDNAPEVTITSVTTAVPENFPPGTIIALISVH 372

Query: 374 DQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDRELVQSYNITLTATDQGSPPL 433
           DQDSG+NG  +CFIP +LPFKLEK   NYY+L+T R LDREL+  YNIT+TA DQG+P L
Sbjct: 373 DQDSGDNGYTTCFIPGNLPFKLEKLVDNYYRLVTERTLDRELISGYNITITAIDQGTPAL 432

Query: 434 SAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDSKQNALVTYSLT 493
           S ETH+ L V D NDN PVF   SYSAYIPENNPRGASIFSV A D DS +NA +TYSL 
Sbjct: 433 STETHISLLVTDINDNSPVFHQDSYSAYIPENNPRGASIFSVRAHDLDSNENAQITYSLI 492

Query: 494 DDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFV 553
           +DT+QG PLS+Y+SINS+TGVLYAL+SFDYEQFRD++L+V+ARDSGDPPLSSNVSLSLF+
Sbjct: 493 EDTIQGAPLSAYLSINSDTGVLYALRSFDYEQFRDMQLKVMARDSGDPPLSSNVSLSLFL 552

Query: 554 LDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKAS 613
           LDQNDNAPEILYPALPTDGSTGVELAP SAEPGYLVTKVVAVD+DSGQNAWLSYRLLKAS
Sbjct: 553 LDQNDNAPEILYPALPTDGSTGVELAPLSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKAS 612

Query: 614 EPGLFAVGEHTGE 626
           EPGLF+VG HTGE
Sbjct: 613 EPGLFSVGLHTGE 625



 Score =  259 bits (663), Expect = 5e-69
 Identities = 125/129 (96%), Positives = 126/129 (97%)

Query: 622 EHTGEQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGS 681
           E   +QAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGS
Sbjct: 803 EPFSQQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGS 862

Query: 682 STLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNK 741
           STLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNK
Sbjct: 863 STLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNK 922

Query: 742 KKSGKKEKK 750
           KKSGKKEKK
Sbjct: 923 KKSGKKEKK 931



 Score =  166 bits (419), Expect = 1e-40
 Identities = 167/574 (29%), Positives = 257/574 (44%), Gaps = 47/574 (8%)

Query: 77  AVNPRSGSLITAGRIDREELCETVSSCFLNM----ELLVEDTLKIYGVEVEIIDINDNAP 132
           A  P+   ++    +DREE  E V    L      E +   TL+IY   ++++D NDN P
Sbjct: 186 ADGPQHPEMVLQSPLDREE--EAVHHLILTASDGGEPVRSGTLRIY---IQVVDANDNPP 240

Query: 133 SFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGAKN 192
           +F + +  I V E+   G +  + NA DPD G N   +Y     ++   Q+  R D    
Sbjct: 241 AFTQAQYHINVPENVPLGTQLLMVNATDPDEGANGEVTYSFHNVDHRVAQIF-RLDSYTG 299

Query: 193 PELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSV 252
            E+  +  LD E+   + + + A DG   + K  V + + VLDVND+ P  T +    +V
Sbjct: 300 -EISNKEPLDFEEYKMYSMEVQAQDGAGLMAK--VKVLIKVLDVNDNAPEVTITSVTTAV 356

Query: 253 PENISSGTRVLMVNATDPDEGING-EVMYSFRNMESKASEIFQLDSQTGEVQVRGSLDFE 311
           PEN   GT + +++  D D G NG    +   N+  K  ++  +D+    V  R +LD E
Sbjct: 357 PENFPPGTIIALISVHDQDSGDNGYTTCFIPGNLPFKLEKL--VDNYYRLVTER-TLDRE 413

Query: 312 KYRFYEMEIQGQDGG--GLFTTTTMLITVVDVNDNAPEITITSSINSILENSPPGTVIAL 369
               Y + I   D G   L T T + + V D+NDN+P     S    I EN+P G  I  
Sbjct: 414 LISGYNITITAIDQGTPALSTETHISLLVTDINDNSPVFHQDSYSAYIPENNPRGASIFS 473

Query: 370 LNVQDQDSGENGQVSCFI--------PNHLPFKLEKTYGNYYKLITSRVLDRELVQSYNI 421
           +   D DS EN Q++  +        P      +    G  Y L   R  D E  +   +
Sbjct: 474 VRAHDLDSNENAQITYSLIEDTIQGAPLSAYLSINSDTGVLYAL---RSFDYEQFRDMQL 530

Query: 422 TLTATDQGSPPLSAETHVWLNVADDNDNPP--VFPH-----SSYSAYIPENNPRGASIFS 474
            + A D G PPLS+   + L + D NDN P  ++P      S+     P +   G  +  
Sbjct: 531 KVMARDSGDPPLSSNVSLSLFLLDQNDNAPEILYPALPTDGSTGVELAPLSAEPGYLVTK 590

Query: 475 VTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVI 534
           V A+D DS QNA ++Y L   +  G+      S+  +TG +   ++          L V 
Sbjct: 591 VVAVDRDSGQNAWLSYRLLKASEPGL-----FSVGLHTGEVRTARALLDRDALKQSLVVA 645

Query: 535 ARDSGDPPLSSNVSLSLFVLDQ-NDNAPEI--LYP-ALPTDGSTGVELAPRSAEPGYLVT 590
            +D G PPLS+ V+L++ V D+ +D   ++  L P A P D    + L   +A    +  
Sbjct: 646 VQDHGQPPLSATVTLTVAVADRISDILADLGSLEPSAKPNDSDLTLYLVVAAAAVSCVFL 705

Query: 591 KVVAVDKDSGQNAWLSYRLLKASEPGLFAV-GEH 623
             V V        W   RLL+AS  GL ++ G H
Sbjct: 706 AFVIVLLAHRLRRWHKSRLLQASGGGLASMPGSH 739


>gi|14196459 protocadherin gamma subfamily A, 1 isoform 2 precursor
           [Homo sapiens]
          Length = 823

 Score =  834 bits (2155), Expect = 0.0
 Identities = 411/613 (67%), Positives = 496/613 (80%)

Query: 14  LLLLCIFLGTLRGFRARQIRYSVPEETEKGSFVGNISKDLGLEPRELAKRGVRIVSRGKT 73
           L+LLC+ L  L    A  I YSVPEET+KGSFVGNI+KDLGL+P+ELA  GVRIVSRG+ 
Sbjct: 13  LMLLCLSLELLLEAGAGNIHYSVPEETDKGSFVGNIAKDLGLQPQELADGGVRIVSRGRM 72

Query: 74  QLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEIIDINDNAPS 133
            LFA+NPRSGSLITA RIDREELC     C ++  +LVED +K++ VEVEIIDINDN P 
Sbjct: 73  PLFALNPRSGSLITARRIDREELCAQSMPCLVSFNILVEDKMKLFPVEVEIIDINDNTPQ 132

Query: 134 FQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGAKNP 193
           FQ +E+E K++E   PG R +LP  +D DVG+NSLQSYQLS N +FSL ++   DG ++P
Sbjct: 133 FQLEELEFKMNEITTPGTRVSLPFGQDLDVGMNSLQSYQLSSNPHFSLDVQQGADGPQHP 192

Query: 194 ELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVP 253
           E+VL+  LDRE+EA H L+LTA DGG+P+R G + I + V+D ND+ P FTQ+ Y ++VP
Sbjct: 193 EMVLQSPLDREEEAVHHLILTASDGGEPVRSGTLRIYIQVVDANDNPPAFTQAQYHINVP 252

Query: 254 ENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGEVQVRGSLDFEKY 313
           EN+  GT++LMVNATDPDEG NGEV YSF N++ + ++IF+LDS TGE+  +  LDFE+Y
Sbjct: 253 ENVPLGTQLLMVNATDPDEGANGEVTYSFHNVDHRVAQIFRLDSYTGEISNKEPLDFEEY 312

Query: 314 RFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILENSPPGTVIALLNVQ 373
           + Y ME+Q QDG GL     +LI V+DVNDNAPE+TITS   ++ EN PPGT+IAL++V 
Sbjct: 313 KMYSMEVQAQDGAGLMAKVKVLIKVLDVNDNAPEVTITSVTTAVPENFPPGTIIALISVH 372

Query: 374 DQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDRELVQSYNITLTATDQGSPPL 433
           DQDSG+NG  +CFIP +LPFKLEK   NYY+L+T R LDREL+  YNIT+TA DQG+P L
Sbjct: 373 DQDSGDNGYTTCFIPGNLPFKLEKLVDNYYRLVTERTLDRELISGYNITITAIDQGTPAL 432

Query: 434 SAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDSKQNALVTYSLT 493
           S ETH+ L V D NDN PVF   SYSAYIPENNPRGASIFSV A D DS +NA +TYSL 
Sbjct: 433 STETHISLLVTDINDNSPVFHQDSYSAYIPENNPRGASIFSVRAHDLDSNENAQITYSLI 492

Query: 494 DDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFV 553
           +DT+QG PLS+Y+SINS+TGVLYAL+SFDYEQFRD++L+V+ARDSGDPPLSSNVSLSLF+
Sbjct: 493 EDTIQGAPLSAYLSINSDTGVLYALRSFDYEQFRDMQLKVMARDSGDPPLSSNVSLSLFL 552

Query: 554 LDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKAS 613
           LDQNDNAPEILYPALPTDGSTGVELAP SAEPGYLVTKVVAVD+DSGQNAWLSYRLLKAS
Sbjct: 553 LDQNDNAPEILYPALPTDGSTGVELAPLSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKAS 612

Query: 614 EPGLFAVGEHTGE 626
           EPGLF+VG HTGE
Sbjct: 613 EPGLFSVGLHTGE 625



 Score =  166 bits (419), Expect = 1e-40
 Identities = 167/574 (29%), Positives = 257/574 (44%), Gaps = 47/574 (8%)

Query: 77  AVNPRSGSLITAGRIDREELCETVSSCFLNM----ELLVEDTLKIYGVEVEIIDINDNAP 132
           A  P+   ++    +DREE  E V    L      E +   TL+IY   ++++D NDN P
Sbjct: 186 ADGPQHPEMVLQSPLDREE--EAVHHLILTASDGGEPVRSGTLRIY---IQVVDANDNPP 240

Query: 133 SFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGAKN 192
           +F + +  I V E+   G +  + NA DPD G N   +Y     ++   Q+  R D    
Sbjct: 241 AFTQAQYHINVPENVPLGTQLLMVNATDPDEGANGEVTYSFHNVDHRVAQIF-RLDSYTG 299

Query: 193 PELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSV 252
            E+  +  LD E+   + + + A DG   + K  V + + VLDVND+ P  T +    +V
Sbjct: 300 -EISNKEPLDFEEYKMYSMEVQAQDGAGLMAK--VKVLIKVLDVNDNAPEVTITSVTTAV 356

Query: 253 PENISSGTRVLMVNATDPDEGING-EVMYSFRNMESKASEIFQLDSQTGEVQVRGSLDFE 311
           PEN   GT + +++  D D G NG    +   N+  K  ++  +D+    V  R +LD E
Sbjct: 357 PENFPPGTIIALISVHDQDSGDNGYTTCFIPGNLPFKLEKL--VDNYYRLVTER-TLDRE 413

Query: 312 KYRFYEMEIQGQDGG--GLFTTTTMLITVVDVNDNAPEITITSSINSILENSPPGTVIAL 369
               Y + I   D G   L T T + + V D+NDN+P     S    I EN+P G  I  
Sbjct: 414 LISGYNITITAIDQGTPALSTETHISLLVTDINDNSPVFHQDSYSAYIPENNPRGASIFS 473

Query: 370 LNVQDQDSGENGQVSCFI--------PNHLPFKLEKTYGNYYKLITSRVLDRELVQSYNI 421
           +   D DS EN Q++  +        P      +    G  Y L   R  D E  +   +
Sbjct: 474 VRAHDLDSNENAQITYSLIEDTIQGAPLSAYLSINSDTGVLYAL---RSFDYEQFRDMQL 530

Query: 422 TLTATDQGSPPLSAETHVWLNVADDNDNPP--VFPH-----SSYSAYIPENNPRGASIFS 474
            + A D G PPLS+   + L + D NDN P  ++P      S+     P +   G  +  
Sbjct: 531 KVMARDSGDPPLSSNVSLSLFLLDQNDNAPEILYPALPTDGSTGVELAPLSAEPGYLVTK 590

Query: 475 VTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVI 534
           V A+D DS QNA ++Y L   +  G+      S+  +TG +   ++          L V 
Sbjct: 591 VVAVDRDSGQNAWLSYRLLKASEPGL-----FSVGLHTGEVRTARALLDRDALKQSLVVA 645

Query: 535 ARDSGDPPLSSNVSLSLFVLDQ-NDNAPEI--LYP-ALPTDGSTGVELAPRSAEPGYLVT 590
            +D G PPLS+ V+L++ V D+ +D   ++  L P A P D    + L   +A    +  
Sbjct: 646 VQDHGQPPLSATVTLTVAVADRISDILADLGSLEPSAKPNDSDLTLYLVVAAAAVSCVFL 705

Query: 591 KVVAVDKDSGQNAWLSYRLLKASEPGLFAV-GEH 623
             V V        W   RLL+AS  GL ++ G H
Sbjct: 706 AFVIVLLAHRLRRWHKSRLLQASGGGLASMPGSH 739


>gi|14589880 protocadherin gamma subfamily A, 3 isoform 1 precursor
           [Homo sapiens]
          Length = 932

 Score =  831 bits (2146), Expect = 0.0
 Identities = 417/615 (67%), Positives = 496/615 (80%)

Query: 12  RLLLLLCIFLGTLRGFRARQIRYSVPEETEKGSFVGNISKDLGLEPRELAKRGVRIVSRG 71
           R L LLC  LGTL    + QIRYSV EE +KGSFVGNI+ DLGLEPRELA+RGVRIVSRG
Sbjct: 11  RGLALLCALLGTLCETGSGQIRYSVSEELDKGSFVGNIANDLGLEPRELAERGVRIVSRG 70

Query: 72  KTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEIIDINDNA 131
           +TQLF++NP+SGSL+TA RIDREELC  +  C + + +LVED LKI+ VE+EI DINDNA
Sbjct: 71  RTQLFSLNPQSGSLVTAERIDREELCAQIPLCLVKINILVEDKLKIFEVEIEIKDINDNA 130

Query: 132 PSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGAK 191
           P+F  +E+EIK+ E  +PG RF +  A DPDVG+NSLQ+Y+LSPN+YFSL +   ++GAK
Sbjct: 131 PNFPTEELEIKIGELTVPGTRFPIKTAFDPDVGINSLQNYKLSPNDYFSLAVNSVSEGAK 190

Query: 192 NPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVS 251
            PELVLE +LDREK+  H L+L A DGGDP+  G + I+V+VLD ND+ PMFTQ  YRVS
Sbjct: 191 YPELVLERALDREKKEIHQLVLVASDGGDPVHSGNLHIQVIVLDANDNPPMFTQPEYRVS 250

Query: 252 VPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGEVQVRGSLDFE 311
           V EN+  GTR+L VNATDPDEG N +V Y    M  K +EIF L+S +GEV +  SLD+E
Sbjct: 251 VWENVPVGTRLLTVNATDPDEGFNAQVSYILDKMPGKIAEIFHLNSVSGEVSILKSLDYE 310

Query: 312 KYRFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILENSPPGTVIALLN 371
              FYE++I+ QDG GL +   +L+TV+DVNDNAPEITITS  +S+ E    G  IAL++
Sbjct: 311 DAMFYEIKIEAQDGPGLLSRAKILVTVLDVNDNAPEITITSLTSSVPEEGTVGREIALID 370

Query: 372 VQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDRELVQSYNITLTATDQGSP 431
           V D+DSG+NGQV  F+  +LPFKLEK+   YY+L+T+  LDRE +  YNI+L A+D GSP
Sbjct: 371 VHDRDSGQNGQVEVFVLGNLPFKLEKSIDQYYRLVTATSLDREQISEYNISLRASDGGSP 430

Query: 432 PLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDSKQNALVTYS 491
           PLS ETH+ L+V D NDNPP FPH SYSAYIPENNPRGASIFSVTA DPDS  NA +TY+
Sbjct: 431 PLSTETHITLHVIDINDNPPTFPHLSYSAYIPENNPRGASIFSVTAQDPDSNNNARITYA 490

Query: 492 LTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPPLSSNVSLSL 551
           LT+DT+QG PLSS+VSINSNTGVLYAL+SFDYEQFRDL+L V A DSG+PPLSSNVSL+L
Sbjct: 491 LTEDTLQGAPLSSFVSINSNTGVLYALRSFDYEQFRDLKLLVTASDSGNPPLSSNVSLNL 550

Query: 552 FVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLK 611
           FVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVD+DSGQNAWLSYRLLK
Sbjct: 551 FVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLK 610

Query: 612 ASEPGLFAVGEHTGE 626
           ASEPGLF+VG HTGE
Sbjct: 611 ASEPGLFSVGLHTGE 625



 Score =  259 bits (662), Expect = 6e-69
 Identities = 124/125 (99%), Positives = 125/125 (100%)

Query: 626 EQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLG 685
           +QAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLG
Sbjct: 808 QQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLG 867

Query: 686 GGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSG 745
           GGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSG
Sbjct: 868 GGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSG 927

Query: 746 KKEKK 750
           KKEKK
Sbjct: 928 KKEKK 932



 Score =  171 bits (433), Expect = 2e-42
 Identities = 158/532 (29%), Positives = 233/532 (43%), Gaps = 48/532 (9%)

Query: 120 VEVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLS--PNN 177
           ++V ++D NDN P F + E  + V E+   G R    NA DPD G N+  SY L   P  
Sbjct: 228 IQVIVLDANDNPPMFTQPEYRVSVWENVPVGTRLLTVNATDPDEGFNAQVSYILDKMPGK 287

Query: 178 YFSLQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVN 237
              +       G    E+ +  SLD E    + + + A DG  P       I V VLDVN
Sbjct: 288 IAEIFHLNSVSG----EVSILKSLDYEDAMFYEIKIEAQDG--PGLLSRAKILVTVLDVN 341

Query: 238 DHIPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEV-MYSFRNMESKASEIFQLD 296
           D+ P  T +    SVPE  + G  + +++  D D G NG+V ++   N+  K  +     
Sbjct: 342 DNAPEITITSLTSSVPEEGTVGREIALIDVHDRDSGQNGQVEVFVLGNLPFKLEKSID-- 399

Query: 297 SQTGEVQVRGSLDFEKYRFYEMEIQGQDGGG--LFTTTTMLITVVDVNDNAPEITITSSI 354
            Q   +    SLD E+   Y + ++  DGG   L T T + + V+D+NDN P     S  
Sbjct: 400 -QYYRLVTATSLDREQISEYNISLRASDGGSPPLSTETHITLHVIDINDNPPTFPHLSYS 458

Query: 355 NSILENSPPGTVIALLNVQDQDSGENGQVSCFI--------PNHLPFKLEKTYGNYYKLI 406
             I EN+P G  I  +  QD DS  N +++  +        P      +    G  Y L 
Sbjct: 459 AYIPENNPRGASIFSVTAQDPDSNNNARITYALTEDTLQGAPLSSFVSINSNTGVLYAL- 517

Query: 407 TSRVLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPP--VFPH-----SSYS 459
             R  D E  +   + +TA+D G+PPLS+   + L V D NDN P  ++P      S+  
Sbjct: 518 --RSFDYEQFRDLKLLVTASDSGNPPLSSNVSLNLFVLDQNDNAPEILYPALPTDGSTGV 575

Query: 460 AYIPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQ 519
              P +   G  +  V A+D DS QNA ++Y L   +  G+      S+  +TG +   +
Sbjct: 576 ELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGL-----FSVGLHTGEVRTAR 630

Query: 520 SFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILY-------PALPTDG 572
           +          L V  +D G PPLS+ V+L++ V D+    P+IL         A P D 
Sbjct: 631 ALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVADR---IPDILADLGSLEPSAKPNDS 687

Query: 573 STGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFAV-GEH 623
              + L    A    +    V V        W   RLL+AS  GL +  G H
Sbjct: 688 DLTLYLVVAVAAVSCVFLAFVIVLLALRLRRWHKSRLLQASGGGLASTPGSH 739


>gi|14196465 protocadherin gamma subfamily A, 3 isoform 2 precursor
           [Homo sapiens]
          Length = 829

 Score =  831 bits (2146), Expect = 0.0
 Identities = 417/615 (67%), Positives = 496/615 (80%)

Query: 12  RLLLLLCIFLGTLRGFRARQIRYSVPEETEKGSFVGNISKDLGLEPRELAKRGVRIVSRG 71
           R L LLC  LGTL    + QIRYSV EE +KGSFVGNI+ DLGLEPRELA+RGVRIVSRG
Sbjct: 11  RGLALLCALLGTLCETGSGQIRYSVSEELDKGSFVGNIANDLGLEPRELAERGVRIVSRG 70

Query: 72  KTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEIIDINDNA 131
           +TQLF++NP+SGSL+TA RIDREELC  +  C + + +LVED LKI+ VE+EI DINDNA
Sbjct: 71  RTQLFSLNPQSGSLVTAERIDREELCAQIPLCLVKINILVEDKLKIFEVEIEIKDINDNA 130

Query: 132 PSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGAK 191
           P+F  +E+EIK+ E  +PG RF +  A DPDVG+NSLQ+Y+LSPN+YFSL +   ++GAK
Sbjct: 131 PNFPTEELEIKIGELTVPGTRFPIKTAFDPDVGINSLQNYKLSPNDYFSLAVNSVSEGAK 190

Query: 192 NPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVS 251
            PELVLE +LDREK+  H L+L A DGGDP+  G + I+V+VLD ND+ PMFTQ  YRVS
Sbjct: 191 YPELVLERALDREKKEIHQLVLVASDGGDPVHSGNLHIQVIVLDANDNPPMFTQPEYRVS 250

Query: 252 VPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGEVQVRGSLDFE 311
           V EN+  GTR+L VNATDPDEG N +V Y    M  K +EIF L+S +GEV +  SLD+E
Sbjct: 251 VWENVPVGTRLLTVNATDPDEGFNAQVSYILDKMPGKIAEIFHLNSVSGEVSILKSLDYE 310

Query: 312 KYRFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILENSPPGTVIALLN 371
              FYE++I+ QDG GL +   +L+TV+DVNDNAPEITITS  +S+ E    G  IAL++
Sbjct: 311 DAMFYEIKIEAQDGPGLLSRAKILVTVLDVNDNAPEITITSLTSSVPEEGTVGREIALID 370

Query: 372 VQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDRELVQSYNITLTATDQGSP 431
           V D+DSG+NGQV  F+  +LPFKLEK+   YY+L+T+  LDRE +  YNI+L A+D GSP
Sbjct: 371 VHDRDSGQNGQVEVFVLGNLPFKLEKSIDQYYRLVTATSLDREQISEYNISLRASDGGSP 430

Query: 432 PLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDSKQNALVTYS 491
           PLS ETH+ L+V D NDNPP FPH SYSAYIPENNPRGASIFSVTA DPDS  NA +TY+
Sbjct: 431 PLSTETHITLHVIDINDNPPTFPHLSYSAYIPENNPRGASIFSVTAQDPDSNNNARITYA 490

Query: 492 LTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPPLSSNVSLSL 551
           LT+DT+QG PLSS+VSINSNTGVLYAL+SFDYEQFRDL+L V A DSG+PPLSSNVSL+L
Sbjct: 491 LTEDTLQGAPLSSFVSINSNTGVLYALRSFDYEQFRDLKLLVTASDSGNPPLSSNVSLNL 550

Query: 552 FVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLK 611
           FVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVD+DSGQNAWLSYRLLK
Sbjct: 551 FVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLK 610

Query: 612 ASEPGLFAVGEHTGE 626
           ASEPGLF+VG HTGE
Sbjct: 611 ASEPGLFSVGLHTGE 625



 Score =  171 bits (433), Expect = 2e-42
 Identities = 158/532 (29%), Positives = 233/532 (43%), Gaps = 48/532 (9%)

Query: 120 VEVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLS--PNN 177
           ++V ++D NDN P F + E  + V E+   G R    NA DPD G N+  SY L   P  
Sbjct: 228 IQVIVLDANDNPPMFTQPEYRVSVWENVPVGTRLLTVNATDPDEGFNAQVSYILDKMPGK 287

Query: 178 YFSLQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVN 237
              +       G    E+ +  SLD E    + + + A DG  P       I V VLDVN
Sbjct: 288 IAEIFHLNSVSG----EVSILKSLDYEDAMFYEIKIEAQDG--PGLLSRAKILVTVLDVN 341

Query: 238 DHIPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEV-MYSFRNMESKASEIFQLD 296
           D+ P  T +    SVPE  + G  + +++  D D G NG+V ++   N+  K  +     
Sbjct: 342 DNAPEITITSLTSSVPEEGTVGREIALIDVHDRDSGQNGQVEVFVLGNLPFKLEKSID-- 399

Query: 297 SQTGEVQVRGSLDFEKYRFYEMEIQGQDGGG--LFTTTTMLITVVDVNDNAPEITITSSI 354
            Q   +    SLD E+   Y + ++  DGG   L T T + + V+D+NDN P     S  
Sbjct: 400 -QYYRLVTATSLDREQISEYNISLRASDGGSPPLSTETHITLHVIDINDNPPTFPHLSYS 458

Query: 355 NSILENSPPGTVIALLNVQDQDSGENGQVSCFI--------PNHLPFKLEKTYGNYYKLI 406
             I EN+P G  I  +  QD DS  N +++  +        P      +    G  Y L 
Sbjct: 459 AYIPENNPRGASIFSVTAQDPDSNNNARITYALTEDTLQGAPLSSFVSINSNTGVLYAL- 517

Query: 407 TSRVLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPP--VFPH-----SSYS 459
             R  D E  +   + +TA+D G+PPLS+   + L V D NDN P  ++P      S+  
Sbjct: 518 --RSFDYEQFRDLKLLVTASDSGNPPLSSNVSLNLFVLDQNDNAPEILYPALPTDGSTGV 575

Query: 460 AYIPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQ 519
              P +   G  +  V A+D DS QNA ++Y L   +  G+      S+  +TG +   +
Sbjct: 576 ELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGL-----FSVGLHTGEVRTAR 630

Query: 520 SFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILY-------PALPTDG 572
           +          L V  +D G PPLS+ V+L++ V D+    P+IL         A P D 
Sbjct: 631 ALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVADR---IPDILADLGSLEPSAKPNDS 687

Query: 573 STGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFAV-GEH 623
              + L    A    +    V V        W   RLL+AS  GL +  G H
Sbjct: 688 DLTLYLVVAVAAVSCVFLAFVIVLLALRLRRWHKSRLLQASGGGLASTPGSH 739


>gi|11056065 protocadherin gamma subfamily A, 6 isoform 1 precursor
           [Homo sapiens]
          Length = 932

 Score =  828 bits (2139), Expect = 0.0
 Identities = 418/626 (66%), Positives = 497/626 (79%), Gaps = 1/626 (0%)

Query: 1   MANRLQRGDRSRLLLLLCIFLGTLRGFRARQIRYSVPEETEKGSFVGNISKDLGLEPREL 60
           MA   +   RS  +LLL + LGTL G  A QIRYS+PEE EKGSFVGNI KDLGLEP+EL
Sbjct: 1   MAPPQRHPQRSEQVLLLTL-LGTLWGAAAAQIRYSIPEELEKGSFVGNIVKDLGLEPQEL 59

Query: 61  AKRGVRIVSRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGV 120
           A+ GVRIVSRG+ QLF++NPR+GSL+TAGRIDREELC     C ++  +LVED L +Y V
Sbjct: 60  AEHGVRIVSRGRMQLFSLNPRNGSLVTAGRIDREELCAQSPRCLVSFNILVEDKLNLYPV 119

Query: 121 EVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFS 180
           EVEI+DINDN P F ++E+E+K+ E+A P +RF L    DPDVG+NSLQ ++LS N++FS
Sbjct: 120 EVEIVDINDNTPRFLKEELEVKILENAAPSSRFPLMEVYDPDVGMNSLQGFKLSGNSHFS 179

Query: 181 LQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHI 240
           + ++    G K PELVLEG+LDRE EA + L+LTA+DGGDP+R     I V VLDVND+ 
Sbjct: 180 VDVQSEAHGPKYPELVLEGTLDREGEAVYRLVLTAMDGGDPVRSSVAQILVTVLDVNDNT 239

Query: 241 PMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTG 300
           PMFTQ VYRVSVPEN+  GT VL V ATD DEG++GEV YSF  +  K S+IF L+  TG
Sbjct: 240 PMFTQPVYRVSVPENLPVGTPVLAVTATDQDEGVHGEVTYSFVKITEKISQIFCLNVLTG 299

Query: 301 EVQVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILEN 360
           E+    +LD+E   FYE+ ++ +DG GL     +LIT++DVNDN PE+ +TS   +I E+
Sbjct: 300 EISTSANLDYEDSSFYELGVEARDGPGLRDRAKVLITILDVNDNVPEVVVTSGSRTIAES 359

Query: 361 SPPGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDRELVQSYN 420
           +PPGTVIAL  V D+DSG NG V+C IP  LPF+LEK+ GNYY+L+T+  LDRE V  YN
Sbjct: 360 APPGTVIALFQVFDRDSGLNGLVTCSIPRSLPFELEKSVGNYYRLVTNAALDREEVFLYN 419

Query: 421 ITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDP 480
           IT+TATD+G+PPLS ET + LNVAD NDNPP FPHSSYS Y+ ENNPRGASIFSV ALDP
Sbjct: 420 ITVTATDKGTPPLSTETIISLNVADTNDNPPTFPHSSYSVYVLENNPRGASIFSVNALDP 479

Query: 481 DSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGD 540
           D  QNA V+YSL +DT+QG PLSSYVSINS+TG+LYAL+SFDYEQ RDL+L V A DSGD
Sbjct: 480 DVDQNAQVSYSLAEDTLQGAPLSSYVSINSDTGILYALRSFDYEQLRDLQLWVTASDSGD 539

Query: 541 PPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSG 600
           PPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVD+DSG
Sbjct: 540 PPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSG 599

Query: 601 QNAWLSYRLLKASEPGLFAVGEHTGE 626
           QNAWLSYRLLKASEPGLF+VG HTGE
Sbjct: 600 QNAWLSYRLLKASEPGLFSVGLHTGE 625



 Score =  360 bits (924), Expect = 3e-99
 Identities = 277/738 (37%), Positives = 378/738 (51%), Gaps = 73/738 (9%)

Query: 33  RYSVPEETEKGSFVGNIS---KDLGLEPRELAKRGVRIVSRGKTQLFAVNPRSGSLITAG 89
           R SVPE    G+ V  ++   +D G+   E+    V+I  +  +Q+F +N  +G + T+ 
Sbjct: 248 RVSVPENLPVGTPVLAVTATDQDEGVHG-EVTYSFVKITEK-ISQIFCLNVLTGEISTSA 305

Query: 90  RIDREELCETVSSCFLNMELLVEDTLKIYG---VEVEIIDINDNAPSFQEDEVEIKVSEH 146
            +D E+      S F  + +   D   +     V + I+D+NDN P          ++E 
Sbjct: 306 NLDYED------SSFYELGVEARDGPGLRDRAKVLITILDVNDNVPEVVVTSGSRTIAES 359

Query: 147 AIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGAKNPELVLEGSLDREKE 206
           A PG   AL    D D G+N L +  +  +  F L+            LV   +LDRE+ 
Sbjct: 360 APPGTVIALFQVFDRDSGLNGLVTCSIPRSLPFELE----KSVGNYYRLVTNAALDREEV 415

Query: 207 AAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVPENISSGTRVLMVN 266
             + + +TA D G P       I + V D ND+ P F  S Y V V EN   G  +  VN
Sbjct: 416 FLYNITVTATDKGTPPLSTETIISLNVADTNDNPPTFPHSSYSVYVLENNPRGASIFSVN 475

Query: 267 ATDPDEGINGEVMYSFRN---MESKASEIFQLDSQTGEVQVRGSLDFEKYRFYEMEIQGQ 323
           A DPD   N +V YS        +  S    ++S TG +    S D+E+ R  ++ +   
Sbjct: 476 ALDPDVDQNAQVSYSLAEDTLQGAPLSSYVSINSDTGILYALRSFDYEQLRDLQLWVTAS 535

Query: 324 DGGG--LFTTTTMLITVVDVNDNAPEITI-------TSSINSILENSPPGTVIALLNVQD 374
           D G   L +  ++ + V+D NDNAPEI         ++ +     ++ PG ++  +   D
Sbjct: 536 DSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVD 595

Query: 375 QDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSR-VLDRELVQSYNITLTATDQGSPPL 433
           +DSG+N  +S  +       L     +  ++ T+R +LDR+ ++  ++ +   D G PPL
Sbjct: 596 RDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQ-SLVVAVQDHGQPPL 654

Query: 434 SAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDSKQNALVTYSLT 493
           SA   V L VA  +  P +                   +  + +L+P +K N      LT
Sbjct: 655 SAT--VTLTVAVADRIPDI-------------------LADLGSLEPSAKPN---DSDLT 690

Query: 494 DDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFV 553
              V  V   S V + +   VL AL+   + + R L+           P S  V +    
Sbjct: 691 LYLVVAVAAVSCVFL-AFVIVLLALRLQRWHKSRLLQAS--GGGLASMPGSHFVGVEGVR 747

Query: 554 LDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKAS 613
                 + E+   +L  D      + P   +P Y  T +     +  +   ++  LL+  
Sbjct: 748 AFLQTYSHEV---SLTADSRKSHLIFP---QPNYADTLINQESYEKSEPLLITQDLLETK 801

Query: 614 -EPGLFAVGEHTGEQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILA 672
            EP          +QAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILA
Sbjct: 802 GEPRQL-------QQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILA 854

Query: 673 SASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGK 732
           SASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGK
Sbjct: 855 SASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGK 914

Query: 733 APAGGNGNKKKSGKKEKK 750
           APAGGNGNKKKSGKKEKK
Sbjct: 915 APAGGNGNKKKSGKKEKK 932



 Score =  152 bits (385), Expect = 8e-37
 Identities = 159/581 (27%), Positives = 243/581 (41%), Gaps = 61/581 (10%)

Query: 77  AVNPRSGSLITAGRIDREELCETVSSCFLN-MELLVEDTLKIYGVEVEIIDINDNAPSFQ 135
           A  P+   L+  G +DRE   E V    L  M+        +  + V ++D+NDN P F 
Sbjct: 186 AHGPKYPELVLEGTLDREG--EAVYRLVLTAMDGGDPVRSSVAQILVTVLDVNDNTPMFT 243

Query: 136 EDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSP-----NNYFSLQLRGRTDGA 190
           +    + V E+   G       A D D GV+   +Y         +  F L +       
Sbjct: 244 QPVYRVSVPENLPVGTPVLAVTATDQDEGVHGEVTYSFVKITEKISQIFCLNVL------ 297

Query: 191 KNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRV 250
              E+    +LD E  + + L + A DG  P  +    + + +LDVND++P    +    
Sbjct: 298 -TGEISTSANLDYEDSSFYELGVEARDG--PGLRDRAKVLITILDVNDNVPEVVVTSGSR 354

Query: 251 SVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGE---VQVRGS 307
           ++ E+   GT + +    D D G+NG V  S        S  F+L+   G    +    +
Sbjct: 355 TIAESAPPGTVIALFQVFDRDSGLNGLVTCSIPR-----SLPFELEKSVGNYYRLVTNAA 409

Query: 308 LDFEKYRFYEMEIQGQDGGG--LFTTTTMLITVVDVNDNAPEITITSSINSILENSPPGT 365
           LD E+   Y + +   D G   L T T + + V D NDN P    +S    +LEN+P G 
Sbjct: 410 LDREEVFLYNITVTATDKGTPPLSTETIISLNVADTNDNPPTFPHSSYSVYVLENNPRGA 469

Query: 366 VIALLNVQDQDSGENGQVSCFI--------PNHLPFKLEKTYGNYYKLITSRVLDRELVQ 417
            I  +N  D D  +N QVS  +        P      +    G  Y L   R  D E ++
Sbjct: 470 SIFSVNALDPDVDQNAQVSYSLAEDTLQGAPLSSYVSINSDTGILYAL---RSFDYEQLR 526

Query: 418 SYNITLTATDQGSPPLSAETHVWLNVADDNDNPP--VFPH-----SSYSAYIPENNPRGA 470
              + +TA+D G PPLS+   + L V D NDN P  ++P      S+     P +   G 
Sbjct: 527 DLQLWVTASDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGY 586

Query: 471 SIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLE 530
            +  V A+D DS QNA ++Y L   +  G+      S+  +TG +   ++          
Sbjct: 587 LVTKVVAVDRDSGQNAWLSYRLLKASEPGL-----FSVGLHTGEVRTARALLDRDALKQS 641

Query: 531 LRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILY-------PALPTDGSTGVELAPRSA 583
           L V  +D G PPLS+ V+L++ V D+    P+IL         A P D    + L    A
Sbjct: 642 LVVAVQDHGQPPLSATVTLTVAVADR---IPDILADLGSLEPSAKPNDSDLTLYLVVAVA 698

Query: 584 EPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFAV-GEH 623
               +    V V        W   RLL+AS  GL ++ G H
Sbjct: 699 AVSCVFLAFVIVLLALRLQRWHKSRLLQASGGGLASMPGSH 739


>gi|14196474 protocadherin gamma subfamily A, 6 isoform 2 precursor
           [Homo sapiens]
          Length = 818

 Score =  828 bits (2139), Expect = 0.0
 Identities = 418/626 (66%), Positives = 497/626 (79%), Gaps = 1/626 (0%)

Query: 1   MANRLQRGDRSRLLLLLCIFLGTLRGFRARQIRYSVPEETEKGSFVGNISKDLGLEPREL 60
           MA   +   RS  +LLL + LGTL G  A QIRYS+PEE EKGSFVGNI KDLGLEP+EL
Sbjct: 1   MAPPQRHPQRSEQVLLLTL-LGTLWGAAAAQIRYSIPEELEKGSFVGNIVKDLGLEPQEL 59

Query: 61  AKRGVRIVSRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGV 120
           A+ GVRIVSRG+ QLF++NPR+GSL+TAGRIDREELC     C ++  +LVED L +Y V
Sbjct: 60  AEHGVRIVSRGRMQLFSLNPRNGSLVTAGRIDREELCAQSPRCLVSFNILVEDKLNLYPV 119

Query: 121 EVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFS 180
           EVEI+DINDN P F ++E+E+K+ E+A P +RF L    DPDVG+NSLQ ++LS N++FS
Sbjct: 120 EVEIVDINDNTPRFLKEELEVKILENAAPSSRFPLMEVYDPDVGMNSLQGFKLSGNSHFS 179

Query: 181 LQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHI 240
           + ++    G K PELVLEG+LDRE EA + L+LTA+DGGDP+R     I V VLDVND+ 
Sbjct: 180 VDVQSEAHGPKYPELVLEGTLDREGEAVYRLVLTAMDGGDPVRSSVAQILVTVLDVNDNT 239

Query: 241 PMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTG 300
           PMFTQ VYRVSVPEN+  GT VL V ATD DEG++GEV YSF  +  K S+IF L+  TG
Sbjct: 240 PMFTQPVYRVSVPENLPVGTPVLAVTATDQDEGVHGEVTYSFVKITEKISQIFCLNVLTG 299

Query: 301 EVQVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILEN 360
           E+    +LD+E   FYE+ ++ +DG GL     +LIT++DVNDN PE+ +TS   +I E+
Sbjct: 300 EISTSANLDYEDSSFYELGVEARDGPGLRDRAKVLITILDVNDNVPEVVVTSGSRTIAES 359

Query: 361 SPPGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDRELVQSYN 420
           +PPGTVIAL  V D+DSG NG V+C IP  LPF+LEK+ GNYY+L+T+  LDRE V  YN
Sbjct: 360 APPGTVIALFQVFDRDSGLNGLVTCSIPRSLPFELEKSVGNYYRLVTNAALDREEVFLYN 419

Query: 421 ITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDP 480
           IT+TATD+G+PPLS ET + LNVAD NDNPP FPHSSYS Y+ ENNPRGASIFSV ALDP
Sbjct: 420 ITVTATDKGTPPLSTETIISLNVADTNDNPPTFPHSSYSVYVLENNPRGASIFSVNALDP 479

Query: 481 DSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGD 540
           D  QNA V+YSL +DT+QG PLSSYVSINS+TG+LYAL+SFDYEQ RDL+L V A DSGD
Sbjct: 480 DVDQNAQVSYSLAEDTLQGAPLSSYVSINSDTGILYALRSFDYEQLRDLQLWVTASDSGD 539

Query: 541 PPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSG 600
           PPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVD+DSG
Sbjct: 540 PPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSG 599

Query: 601 QNAWLSYRLLKASEPGLFAVGEHTGE 626
           QNAWLSYRLLKASEPGLF+VG HTGE
Sbjct: 600 QNAWLSYRLLKASEPGLFSVGLHTGE 625



 Score =  152 bits (385), Expect = 8e-37
 Identities = 159/581 (27%), Positives = 243/581 (41%), Gaps = 61/581 (10%)

Query: 77  AVNPRSGSLITAGRIDREELCETVSSCFLN-MELLVEDTLKIYGVEVEIIDINDNAPSFQ 135
           A  P+   L+  G +DRE   E V    L  M+        +  + V ++D+NDN P F 
Sbjct: 186 AHGPKYPELVLEGTLDREG--EAVYRLVLTAMDGGDPVRSSVAQILVTVLDVNDNTPMFT 243

Query: 136 EDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSP-----NNYFSLQLRGRTDGA 190
           +    + V E+   G       A D D GV+   +Y         +  F L +       
Sbjct: 244 QPVYRVSVPENLPVGTPVLAVTATDQDEGVHGEVTYSFVKITEKISQIFCLNVL------ 297

Query: 191 KNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRV 250
              E+    +LD E  + + L + A DG  P  +    + + +LDVND++P    +    
Sbjct: 298 -TGEISTSANLDYEDSSFYELGVEARDG--PGLRDRAKVLITILDVNDNVPEVVVTSGSR 354

Query: 251 SVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGE---VQVRGS 307
           ++ E+   GT + +    D D G+NG V  S        S  F+L+   G    +    +
Sbjct: 355 TIAESAPPGTVIALFQVFDRDSGLNGLVTCSIPR-----SLPFELEKSVGNYYRLVTNAA 409

Query: 308 LDFEKYRFYEMEIQGQDGGG--LFTTTTMLITVVDVNDNAPEITITSSINSILENSPPGT 365
           LD E+   Y + +   D G   L T T + + V D NDN P    +S    +LEN+P G 
Sbjct: 410 LDREEVFLYNITVTATDKGTPPLSTETIISLNVADTNDNPPTFPHSSYSVYVLENNPRGA 469

Query: 366 VIALLNVQDQDSGENGQVSCFI--------PNHLPFKLEKTYGNYYKLITSRVLDRELVQ 417
            I  +N  D D  +N QVS  +        P      +    G  Y L   R  D E ++
Sbjct: 470 SIFSVNALDPDVDQNAQVSYSLAEDTLQGAPLSSYVSINSDTGILYAL---RSFDYEQLR 526

Query: 418 SYNITLTATDQGSPPLSAETHVWLNVADDNDNPP--VFPH-----SSYSAYIPENNPRGA 470
              + +TA+D G PPLS+   + L V D NDN P  ++P      S+     P +   G 
Sbjct: 527 DLQLWVTASDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGY 586

Query: 471 SIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLE 530
            +  V A+D DS QNA ++Y L   +  G+      S+  +TG +   ++          
Sbjct: 587 LVTKVVAVDRDSGQNAWLSYRLLKASEPGL-----FSVGLHTGEVRTARALLDRDALKQS 641

Query: 531 LRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILY-------PALPTDGSTGVELAPRSA 583
           L V  +D G PPLS+ V+L++ V D+    P+IL         A P D    + L    A
Sbjct: 642 LVVAVQDHGQPPLSATVTLTVAVADR---IPDILADLGSLEPSAKPNDSDLTLYLVVAVA 698

Query: 584 EPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFAV-GEH 623
               +    V V        W   RLL+AS  GL ++ G H
Sbjct: 699 AVSCVFLAFVIVLLALRLQRWHKSRLLQASGGGLASMPGSH 739


>gi|11056063 protocadherin gamma subfamily A, 7 isoform 1 precursor
           [Homo sapiens]
          Length = 932

 Score =  822 bits (2122), Expect = 0.0
 Identities = 412/620 (66%), Positives = 492/620 (79%)

Query: 7   RGDRSRLLLLLCIFLGTLRGFRARQIRYSVPEETEKGSFVGNISKDLGLEPRELAKRGVR 66
           RG   R   LL I LGT     A +I YSV EET+KGSFVG+I+KDLGLEPRELA+RGVR
Sbjct: 6   RGGDYRGFFLLSILLGTPWEAWAGRILYSVSEETDKGSFVGDIAKDLGLEPRELAERGVR 65

Query: 67  IVSRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEIID 126
           I+SRG+TQLFA+N RSGSL+TAGRIDREE+C   + C +N  +L+ED + +Y ++VEIID
Sbjct: 66  IISRGRTQLFALNQRSGSLVTAGRIDREEICAQSARCLVNFNILMEDKMNLYPIDVEIID 125

Query: 127 INDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGR 186
           INDN P F  +E+ +K+ E+  PG RF L  A DPDVG NSLQSYQLSPN +FSL ++  
Sbjct: 126 INDNVPRFLTEEINVKIMENTAPGVRFPLSEAGDPDVGTNSLQSYQLSPNRHFSLAVQSG 185

Query: 187 TDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQS 246
            D  K PELVLE  LDRE+E  H L+LTA DGGDP R     I+V V+DVNDH P+F+  
Sbjct: 186 DDETKYPELVLERVLDREEERVHHLVLTASDGGDPPRSSTAHIQVTVVDVNDHTPVFSLP 245

Query: 247 VYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGEVQVRG 306
            Y+V+VPEN+  GTR+L V+A D DEG+NGEV YSFR +  K  ++F L+S TGE+    
Sbjct: 246 QYQVTVPENVPVGTRLLTVHAIDLDEGVNGEVTYSFRKITPKLPKMFHLNSLTGEISTLE 305

Query: 307 SLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILENSPPGTV 366
            LD+E+  FYEME+Q QDG G  T   +LITV+DVNDNAPE+T+TS  +SI E++P GTV
Sbjct: 306 GLDYEETAFYEMEVQAQDGPGSLTKAKVLITVLDVNDNAPEVTMTSLSSSIPEDTPLGTV 365

Query: 367 IALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDRELVQSYNITLTAT 426
           IAL  +QD+DSG+NG+V+C IP +LPFKLEK+  NYY+L+T++ LDRE +  YNITL AT
Sbjct: 366 IALFYLQDRDSGKNGEVTCTIPENLPFKLEKSIDNYYRLVTTKNLDRETLSLYNITLKAT 425

Query: 427 DQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDSKQNA 486
           D G+PPLS ETH+++ VAD NDNPP FPHSSYS YI ENNPRGASIF VTA D DS+ NA
Sbjct: 426 DGGTPPLSRETHIFMQVADTNDNPPTFPHSSYSVYIAENNPRGASIFLVTAQDHDSEDNA 485

Query: 487 LVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPPLSSN 546
            +TYSL +DT+QG P+SSYVSINS+TGVLYALQSFDYEQ R+L+LRV A DSGDPPLSSN
Sbjct: 486 QITYSLAEDTIQGAPVSSYVSINSDTGVLYALQSFDYEQLRELQLRVTAHDSGDPPLSSN 545

Query: 547 VSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLS 606
           +SLSLFVLDQNDN PEILYPALPTDGSTG+ELAPRSAEPGYLVTKVVAVDKDSGQNAWLS
Sbjct: 546 MSLSLFVLDQNDNPPEILYPALPTDGSTGMELAPRSAEPGYLVTKVVAVDKDSGQNAWLS 605

Query: 607 YRLLKASEPGLFAVGEHTGE 626
           Y LLKASEPGLFAVG +TGE
Sbjct: 606 YLLLKASEPGLFAVGLYTGE 625



 Score =  358 bits (920), Expect = 8e-99
 Identities = 277/746 (37%), Positives = 379/746 (50%), Gaps = 77/746 (10%)

Query: 27  FRARQIRYSVPEETEKGS---FVGNISKDLGLEPRELAKRGVRIVSRGKTQLFAVNPRSG 83
           F   Q + +VPE    G+    V  I  D G+          R ++    ++F +N  +G
Sbjct: 242 FSLPQYQVTVPENVPVGTRLLTVHAIDLDEGVNGE--VTYSFRKITPKLPKMFHLNSLTG 299

Query: 84  SLITAGRIDREELCETVSSCFLNMELLVED---TLKIYGVEVEIIDINDNAPSFQEDEVE 140
            + T   +D EE      + F  ME+  +D   +L    V + ++D+NDNAP      + 
Sbjct: 300 EISTLEGLDYEE------TAFYEMEVQAQDGPGSLTKAKVLITVLDVNDNAPEVTMTSLS 353

Query: 141 IKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGAKNPELVLEGS 200
             + E    G   AL   +D D G N   +  +  N  F L+            LV   +
Sbjct: 354 SSIPEDTPLGTVIALFYLQDRDSGKNGEVTCTIPENLPFKLE----KSIDNYYRLVTTKN 409

Query: 201 LDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVPENISSGT 260
           LDRE  + + + L A DGG P       I + V D ND+ P F  S Y V + EN   G 
Sbjct: 410 LDRETLSLYNITLKATDGGTPPLSRETHIFMQVADTNDNPPTFPHSSYSVYIAENNPRGA 469

Query: 261 RVLMVNATDPDEGINGEVMYSFRN---MESKASEIFQLDSQTGEVQVRGSLDFEKYRFYE 317
            + +V A D D   N ++ YS        +  S    ++S TG +    S D+E+ R  +
Sbjct: 470 SIFLVTAQDHDSEDNAQITYSLAEDTIQGAPVSSYVSINSDTGVLYALQSFDYEQLRELQ 529

Query: 318 MEIQGQDGGG--LFTTTTMLITVVDVNDNAPEI---TITSSINSILENSP----PGTVIA 368
           + +   D G   L +  ++ + V+D NDN PEI    + +  ++ +E +P    PG ++ 
Sbjct: 530 LRVTAHDSGDPPLSSNMSLSLFVLDQNDNPPEILYPALPTDGSTGMELAPRSAEPGYLVT 589

Query: 369 LLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSR-VLDRELVQSYNITLTATD 427
            +   D+DSG+N  +S  +       L        ++ T+R +LDR+ ++  ++ +   D
Sbjct: 590 KVVAVDKDSGQNAWLSYLLLKASEPGLFAVGLYTGEVRTARALLDRDALKQ-SLVVAVQD 648

Query: 428 QGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDSKQNAL 487
            G PPLSA   + + VAD                IPE       +  + +L+P    +  
Sbjct: 649 HGQPPLSATVTLTVAVADS---------------IPE------VLADLGSLEPS---DGP 684

Query: 488 VTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPPLSSNV 547
             Y LT   V  V   S V + +   VL AL+   + + R L+    A + G     +NV
Sbjct: 685 YNYDLTLYLVVAVATVSCVFL-AFVLVLLALRLRRWHKSRLLQ----ASEGG----LANV 735

Query: 548 SLSLFVLDQNDNAPEILYP---ALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAW 604
             S FV      A    Y    +L  D      + P+      L+++      DS   + 
Sbjct: 736 PTSHFVGMDGVQAFLQTYSHEVSLTADSRKSHLIFPQPNYVDMLISQESCEKNDSLLTS- 794

Query: 605 LSYRLLKASEPGLFAVGEHTGEQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTE 664
           + ++  K + P +        +QAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTE
Sbjct: 795 VDFQECKENLPSI--------QQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTE 846

Query: 665 MLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTN 724
           MLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTN
Sbjct: 847 MLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTN 906

Query: 725 AAGKRDGKAPAGGNGNKKKSGKKEKK 750
           AAGKRDGKAPAGGNGNKKKSGKKEKK
Sbjct: 907 AAGKRDGKAPAGGNGNKKKSGKKEKK 932



 Score =  165 bits (417), Expect = 2e-40
 Identities = 156/529 (29%), Positives = 232/529 (43%), Gaps = 55/529 (10%)

Query: 120 VEVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSY---QLSPN 176
           ++V ++D+ND+ P F   + ++ V E+   G R    +A D D GVN   +Y   +++P 
Sbjct: 228 IQVTVVDVNDHTPVFSLPQYQVTVPENVPVGTRLLTVHAIDLDEGVNGEVTYSFRKITPK 287

Query: 177 NYFSLQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDV 236
                 L   T         LEG LD E+ A + + + A DG   + K  V I   VLDV
Sbjct: 288 LPKMFHLNSLTGEIST----LEG-LDYEETAFYEMEVQAQDGPGSLTKAKVLI--TVLDV 340

Query: 237 NDHIPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSF-RNMESKASEIFQL 295
           ND+ P  T +    S+PE+   GT + +    D D G NGEV  +   N+  K  +   +
Sbjct: 341 NDNAPEVTMTSLSSSIPEDTPLGTVIALFYLQDRDSGKNGEVTCTIPENLPFKLEK--SI 398

Query: 296 DSQTGEVQVRGSLDFEKYRFYEMEIQGQDGGG--LFTTTTMLITVVDVNDNAPEITITSS 353
           D+    V  + +LD E    Y + ++  DGG   L   T + + V D NDN P    +S 
Sbjct: 399 DNYYRLVTTK-NLDRETLSLYNITLKATDGGTPPLSRETHIFMQVADTNDNPPTFPHSSY 457

Query: 354 INSILENSPPGTVIALLNVQDQDSGENGQVSCFI--------PNHLPFKLEKTYGNYYKL 405
              I EN+P G  I L+  QD DS +N Q++  +        P      +    G  Y L
Sbjct: 458 SVYIAENNPRGASIFLVTAQDHDSEDNAQITYSLAEDTIQGAPVSSYVSINSDTGVLYAL 517

Query: 406 ITSRVLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPP--VFPH-----SSY 458
              +  D E ++   + +TA D G PPLS+   + L V D NDNPP  ++P      S+ 
Sbjct: 518 ---QSFDYEQLRELQLRVTAHDSGDPPLSSNMSLSLFVLDQNDNPPEILYPALPTDGSTG 574

Query: 459 SAYIPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYAL 518
               P +   G  +  V A+D DS QNA ++Y L   +  G+      ++   TG +   
Sbjct: 575 MELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYLLLKASEPGL-----FAVGLYTGEVRTA 629

Query: 519 QSFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVEL 578
           ++          L V  +D G PPLS+ V+L++ V D        L    P+DG    +L
Sbjct: 630 RALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVADSIPEVLADLGSLEPSDGPYNYDL 689

Query: 579 APRSAEPGYLVTKVVAVD----------KDSGQNAWLSYRLLKASEPGL 617
                   YLV  V  V                  W   RLL+ASE GL
Sbjct: 690 TL------YLVVAVATVSCVFLAFVLVLLALRLRRWHKSRLLQASEGGL 732


>gi|14196477 protocadherin gamma subfamily A, 7 isoform 2 precursor
           [Homo sapiens]
          Length = 817

 Score =  822 bits (2122), Expect = 0.0
 Identities = 412/620 (66%), Positives = 492/620 (79%)

Query: 7   RGDRSRLLLLLCIFLGTLRGFRARQIRYSVPEETEKGSFVGNISKDLGLEPRELAKRGVR 66
           RG   R   LL I LGT     A +I YSV EET+KGSFVG+I+KDLGLEPRELA+RGVR
Sbjct: 6   RGGDYRGFFLLSILLGTPWEAWAGRILYSVSEETDKGSFVGDIAKDLGLEPRELAERGVR 65

Query: 67  IVSRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEIID 126
           I+SRG+TQLFA+N RSGSL+TAGRIDREE+C   + C +N  +L+ED + +Y ++VEIID
Sbjct: 66  IISRGRTQLFALNQRSGSLVTAGRIDREEICAQSARCLVNFNILMEDKMNLYPIDVEIID 125

Query: 127 INDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGR 186
           INDN P F  +E+ +K+ E+  PG RF L  A DPDVG NSLQSYQLSPN +FSL ++  
Sbjct: 126 INDNVPRFLTEEINVKIMENTAPGVRFPLSEAGDPDVGTNSLQSYQLSPNRHFSLAVQSG 185

Query: 187 TDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQS 246
            D  K PELVLE  LDRE+E  H L+LTA DGGDP R     I+V V+DVNDH P+F+  
Sbjct: 186 DDETKYPELVLERVLDREEERVHHLVLTASDGGDPPRSSTAHIQVTVVDVNDHTPVFSLP 245

Query: 247 VYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGEVQVRG 306
            Y+V+VPEN+  GTR+L V+A D DEG+NGEV YSFR +  K  ++F L+S TGE+    
Sbjct: 246 QYQVTVPENVPVGTRLLTVHAIDLDEGVNGEVTYSFRKITPKLPKMFHLNSLTGEISTLE 305

Query: 307 SLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILENSPPGTV 366
            LD+E+  FYEME+Q QDG G  T   +LITV+DVNDNAPE+T+TS  +SI E++P GTV
Sbjct: 306 GLDYEETAFYEMEVQAQDGPGSLTKAKVLITVLDVNDNAPEVTMTSLSSSIPEDTPLGTV 365

Query: 367 IALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDRELVQSYNITLTAT 426
           IAL  +QD+DSG+NG+V+C IP +LPFKLEK+  NYY+L+T++ LDRE +  YNITL AT
Sbjct: 366 IALFYLQDRDSGKNGEVTCTIPENLPFKLEKSIDNYYRLVTTKNLDRETLSLYNITLKAT 425

Query: 427 DQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDSKQNA 486
           D G+PPLS ETH+++ VAD NDNPP FPHSSYS YI ENNPRGASIF VTA D DS+ NA
Sbjct: 426 DGGTPPLSRETHIFMQVADTNDNPPTFPHSSYSVYIAENNPRGASIFLVTAQDHDSEDNA 485

Query: 487 LVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPPLSSN 546
            +TYSL +DT+QG P+SSYVSINS+TGVLYALQSFDYEQ R+L+LRV A DSGDPPLSSN
Sbjct: 486 QITYSLAEDTIQGAPVSSYVSINSDTGVLYALQSFDYEQLRELQLRVTAHDSGDPPLSSN 545

Query: 547 VSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLS 606
           +SLSLFVLDQNDN PEILYPALPTDGSTG+ELAPRSAEPGYLVTKVVAVDKDSGQNAWLS
Sbjct: 546 MSLSLFVLDQNDNPPEILYPALPTDGSTGMELAPRSAEPGYLVTKVVAVDKDSGQNAWLS 605

Query: 607 YRLLKASEPGLFAVGEHTGE 626
           Y LLKASEPGLFAVG +TGE
Sbjct: 606 YLLLKASEPGLFAVGLYTGE 625



 Score =  165 bits (417), Expect = 2e-40
 Identities = 156/529 (29%), Positives = 232/529 (43%), Gaps = 55/529 (10%)

Query: 120 VEVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSY---QLSPN 176
           ++V ++D+ND+ P F   + ++ V E+   G R    +A D D GVN   +Y   +++P 
Sbjct: 228 IQVTVVDVNDHTPVFSLPQYQVTVPENVPVGTRLLTVHAIDLDEGVNGEVTYSFRKITPK 287

Query: 177 NYFSLQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDV 236
                 L   T         LEG LD E+ A + + + A DG   + K  V I   VLDV
Sbjct: 288 LPKMFHLNSLTGEIST----LEG-LDYEETAFYEMEVQAQDGPGSLTKAKVLI--TVLDV 340

Query: 237 NDHIPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSF-RNMESKASEIFQL 295
           ND+ P  T +    S+PE+   GT + +    D D G NGEV  +   N+  K  +   +
Sbjct: 341 NDNAPEVTMTSLSSSIPEDTPLGTVIALFYLQDRDSGKNGEVTCTIPENLPFKLEK--SI 398

Query: 296 DSQTGEVQVRGSLDFEKYRFYEMEIQGQDGGG--LFTTTTMLITVVDVNDNAPEITITSS 353
           D+    V  + +LD E    Y + ++  DGG   L   T + + V D NDN P    +S 
Sbjct: 399 DNYYRLVTTK-NLDRETLSLYNITLKATDGGTPPLSRETHIFMQVADTNDNPPTFPHSSY 457

Query: 354 INSILENSPPGTVIALLNVQDQDSGENGQVSCFI--------PNHLPFKLEKTYGNYYKL 405
              I EN+P G  I L+  QD DS +N Q++  +        P      +    G  Y L
Sbjct: 458 SVYIAENNPRGASIFLVTAQDHDSEDNAQITYSLAEDTIQGAPVSSYVSINSDTGVLYAL 517

Query: 406 ITSRVLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPP--VFPH-----SSY 458
              +  D E ++   + +TA D G PPLS+   + L V D NDNPP  ++P      S+ 
Sbjct: 518 ---QSFDYEQLRELQLRVTAHDSGDPPLSSNMSLSLFVLDQNDNPPEILYPALPTDGSTG 574

Query: 459 SAYIPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYAL 518
               P +   G  +  V A+D DS QNA ++Y L   +  G+      ++   TG +   
Sbjct: 575 MELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYLLLKASEPGL-----FAVGLYTGEVRTA 629

Query: 519 QSFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVEL 578
           ++          L V  +D G PPLS+ V+L++ V D        L    P+DG    +L
Sbjct: 630 RALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVADSIPEVLADLGSLEPSDGPYNYDL 689

Query: 579 APRSAEPGYLVTKVVAVD----------KDSGQNAWLSYRLLKASEPGL 617
                   YLV  V  V                  W   RLL+ASE GL
Sbjct: 690 TL------YLVVAVATVSCVFLAFVLVLLALRLRRWHKSRLLQASEGGL 732


>gi|11128043 protocadherin gamma subfamily A, 9 isoform 1 precursor
           [Homo sapiens]
          Length = 932

 Score =  812 bits (2097), Expect = 0.0
 Identities = 405/613 (66%), Positives = 485/613 (79%)

Query: 14  LLLLCIFLGTLRGFRARQIRYSVPEETEKGSFVGNISKDLGLEPRELAKRGVRIVSRGKT 73
           L+LLC  LG L   RA QIRYSVPEETEKG  VGNISKDL LEPRELA+R VRIVSRG+T
Sbjct: 13  LVLLCSLLGMLWEARASQIRYSVPEETEKGYIVGNISKDLALEPRELAERRVRIVSRGRT 72

Query: 74  QLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEIIDINDNAPS 133
           QLF++NPRSG+L+TAGRIDREELC     C +N ++LVED +K+YG+E+E+ DIND+AP 
Sbjct: 73  QLFSLNPRSGTLVTAGRIDREELCAQSPRCLVNFKVLVEDRVKLYGIEIEVTDINDSAPK 132

Query: 134 FQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGAKNP 193
           FQ + +E+K++E A+PGAR+ LP A DPDVGVNSLQSYQLSPN++FSL ++   +GA NP
Sbjct: 133 FQAESLEVKINEIAVPGARYPLPEAIDPDVGVNSLQSYQLSPNHHFSLNVQTGDNGAINP 192

Query: 194 ELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVP 253
           ELVLE +LDRE+  AH L+LTA DGG+P R   V I V VLD ND+ P+F Q +YRV V 
Sbjct: 193 ELVLERALDREEATAHHLVLTASDGGEPRRSSTVRIHVTVLDTNDNAPVFAQRIYRVKVL 252

Query: 254 ENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGEVQVRGSLDFEKY 313
           EN+  GT +L   A+D DEGING+V Y F  +  K S +FQL+  TGE+    SLD+E+ 
Sbjct: 253 ENVPPGTWLLTATASDLDEGINGKVAYKFWKINEKQSLLFQLNENTGEISTAKSLDYEEC 312

Query: 314 RFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILENSPPGTVIALLNVQ 373
            FYEMEIQ +DGGGL   T +LI+V DVNDN PE+TITS  + + E++P GTVI L N  
Sbjct: 313 SFYEMEIQAEDGGGLKGWTKVLISVEDVNDNRPEVTITSLFSPVREDAPQGTVILLFNAH 372

Query: 374 DQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDRELVQSYNITLTATDQGSPPL 433
           D+DSG+NGQV C I  +L F LE +  +YY+L+T+++LDRE    YNIT+TATD+G+PPL
Sbjct: 373 DRDSGKNGQVVCSIQENLSFTLENSEEDYYRLLTAQILDREKASEYNITVTATDRGTPPL 432

Query: 434 SAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDSKQNALVTYSLT 493
           S E H+ L V D NDNPP F  +SYS Y+PENN RG SIFSV A DPDS +N+ V YSL 
Sbjct: 433 STEIHITLQVTDINDNPPAFSQASYSVYLPENNARGTSIFSVIAYDPDSNENSRVIYSLA 492

Query: 494 DDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFV 553
           +DT+QG PLS+YVSINS+TGVLYAL SFDYEQFRDL+++V A DSG PPLSSNVSL LFV
Sbjct: 493 EDTIQGSPLSTYVSINSDTGVLYALCSFDYEQFRDLQMQVTASDSGSPPLSSNVSLRLFV 552

Query: 554 LDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKAS 613
           LDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVD+DSGQNAWLSYRL KAS
Sbjct: 553 LDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLFKAS 612

Query: 614 EPGLFAVGEHTGE 626
           EPGLF+VG HTGE
Sbjct: 613 EPGLFSVGLHTGE 625



 Score =  377 bits (967), Expect = e-104
 Identities = 269/717 (37%), Positives = 363/717 (50%), Gaps = 102/717 (14%)

Query: 68  VSRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYG---VEVEI 124
           ++  ++ LF +N  +G + TA  +D EE        F  ME+  ED   + G   V + +
Sbjct: 284 INEKQSLLFQLNENTGEISTAKSLDYEECS------FYEMEIQAEDGGGLKGWTKVLISV 337

Query: 125 IDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLR 184
            D+NDN P      +   V E A  G    L NA D D G N      +  N  F+L+  
Sbjct: 338 EDVNDNRPEVTITSLFSPVREDAPQGTVILLFNAHDRDSGKNGQVVCSIQENLSFTLE-- 395

Query: 185 GRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFT 244
                     L+    LDREK + + + +TA D G P     + I + V D+ND+ P F+
Sbjct: 396 --NSEEDYYRLLTAQILDREKASEYNITVTATDRGTPPLSTEIHITLQVTDINDNPPAFS 453

Query: 245 QSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRN---MESKASEIFQLDSQTGE 301
           Q+ Y V +PEN + GT +  V A DPD   N  V+YS        S  S    ++S TG 
Sbjct: 454 QASYSVYLPENNARGTSIFSVIAYDPDSNENSRVIYSLAEDTIQGSPLSTYVSINSDTGV 513

Query: 302 VQVRGSLDFEKYRFYEMEIQGQDGGG--LFTTTTMLITVVDVNDNAPEITI-------TS 352
           +    S D+E++R  +M++   D G   L +  ++ + V+D NDNAPEI         ++
Sbjct: 514 LYALCSFDYEQFRDLQMQVTASDSGSPPLSSNVSLRLFVLDQNDNAPEILYPALPTDGST 573

Query: 353 SINSILENSPPGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSR-VL 411
            +     ++ PG ++  +   D+DSG+N  +S  +       L     +  ++ T+R +L
Sbjct: 574 GVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLFKASEPGLFSVGLHTGEVRTARALL 633

Query: 412 DRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPEN-NPRGA 470
           DR+ ++  ++ +   D G PPLSA   + + +A   D+ P       S  IP +      
Sbjct: 634 DRDALKQ-SLVVAVQDHGQPPLSATVTLTVAIA---DSIPDILADLGSLQIPADLEASDL 689

Query: 471 SIFSVTALDPDSKQNALVTYSL----------------TDDTVQGVPLSSYVSINSNTGV 514
           +++ V A+   S        +L                T D + GVP S +V ++   GV
Sbjct: 690 TLYLVVAVAVVSCVFLTFVITLLALRLRHWHSSHLLRATSDGLAGVPTSHFVGVD---GV 746

Query: 515 LYALQSFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGST 574
              LQ++  E                           F L  +     +++P        
Sbjct: 747 RAFLQTYSQE---------------------------FSLTADSRKSHLIFP-------- 771

Query: 575 GVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFAVGEHT-GEQAPPNTD 633
                    +P Y  T +        Q +      L  S    F + +     QAPPNTD
Sbjct: 772 ---------QPNYADTLI-------SQQSCEKNEPLCVSVDSKFPIEDTPLVPQAPPNTD 815

Query: 634 WRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGL 693
           WRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGL
Sbjct: 816 WRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGL 875

Query: 694 SARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK 750
           SARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK
Sbjct: 876 SARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK 932



 Score =  155 bits (392), Expect = 1e-37
 Identities = 160/559 (28%), Positives = 248/559 (44%), Gaps = 64/559 (11%)

Query: 33  RYSVPEETEKGSFVGNISKDLGLEPRELAKRGVRIVSRGKTQLFAVNPRSGSLITAGRID 92
           RY +PE  +    V ++ +   L P       V+    G     A+NP    L+    +D
Sbjct: 151 RYPLPEAIDPDVGVNSL-QSYQLSPNHHFSLNVQTGDNG-----AINPE---LVLERALD 201

Query: 93  REELC--ETVSSCFLNMELLVEDTLKIYGVEVEIIDINDNAPSFQEDEVEIKVSEHAIPG 150
           REE      V +     E     T++I+   V ++D NDNAP F +    +KV E+  PG
Sbjct: 202 REEATAHHLVLTASDGGEPRRSSTVRIH---VTVLDTNDNAPVFAQRIYRVKVLENVPPG 258

Query: 151 ARFALPNARDPDVGVNSLQSYQ---LSPNNYFSLQLRGRTDGAKNPELVLEGSLDREKEA 207
                  A D D G+N   +Y+   ++       QL   T      E+    SLD E+ +
Sbjct: 259 TWLLTATASDLDEGINGKVAYKFWKINEKQSLLFQLNENTG-----EISTAKSLDYEECS 313

Query: 208 AHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVPENISSGTRVLMVNA 267
            + + + A DGG    KG   + + V DVND+ P  T +     V E+   GT +L+ NA
Sbjct: 314 FYEMEIQAEDGGG--LKGWTKVLISVEDVNDNRPEVTITSLFSPVREDAPQGTVILLFNA 371

Query: 268 TDPDEGINGEVMYSFRN-----MESKASEIFQLDSQTGEVQVRGSLDFEKYRFYEMEIQG 322
            D D G NG+V+ S +      +E+   + ++L   T ++     LD EK   Y + +  
Sbjct: 372 HDRDSGKNGQVVCSIQENLSFTLENSEEDYYRL--LTAQI-----LDREKASEYNITVTA 424

Query: 323 QDGGGLFTTTTMLIT--VVDVNDNAPEITITSSINSILENSPPGTVIALLNVQDQDSGEN 380
            D G    +T + IT  V D+NDN P  +  S    + EN+  GT I  +   D DS EN
Sbjct: 425 TDRGTPPLSTEIHITLQVTDINDNPPAFSQASYSVYLPENNARGTSIFSVIAYDPDSNEN 484

Query: 381 GQVSCFI--------PNHLPFKLEKTYGNYYKLITSRVLDRELVQSYNITLTATDQGSPP 432
            +V   +        P      +    G  Y L +    D E  +   + +TA+D GSPP
Sbjct: 485 SRVIYSLAEDTIQGSPLSTYVSINSDTGVLYALCS---FDYEQFRDLQMQVTASDSGSPP 541

Query: 433 LSAETHVWLNVADDNDNPP--VFPH-----SSYSAYIPENNPRGASIFSVTALDPDSKQN 485
           LS+   + L V D NDN P  ++P      S+     P +   G  +  V A+D DS QN
Sbjct: 542 LSSNVSLRLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQN 601

Query: 486 ALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPPLSS 545
           A ++Y L   +  G+      S+  +TG +   ++          L V  +D G PPLS+
Sbjct: 602 AWLSYRLFKASEPGL-----FSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSA 656

Query: 546 NVSLSLFVLDQNDNAPEIL 564
            V+L++ +    D+ P+IL
Sbjct: 657 TVTLTVAIA---DSIPDIL 672


>gi|14270487 protocadherin gamma subfamily A, 9 isoform 2 precursor
           [Homo sapiens]
          Length = 828

 Score =  812 bits (2097), Expect = 0.0
 Identities = 405/613 (66%), Positives = 485/613 (79%)

Query: 14  LLLLCIFLGTLRGFRARQIRYSVPEETEKGSFVGNISKDLGLEPRELAKRGVRIVSRGKT 73
           L+LLC  LG L   RA QIRYSVPEETEKG  VGNISKDL LEPRELA+R VRIVSRG+T
Sbjct: 13  LVLLCSLLGMLWEARASQIRYSVPEETEKGYIVGNISKDLALEPRELAERRVRIVSRGRT 72

Query: 74  QLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEIIDINDNAPS 133
           QLF++NPRSG+L+TAGRIDREELC     C +N ++LVED +K+YG+E+E+ DIND+AP 
Sbjct: 73  QLFSLNPRSGTLVTAGRIDREELCAQSPRCLVNFKVLVEDRVKLYGIEIEVTDINDSAPK 132

Query: 134 FQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGAKNP 193
           FQ + +E+K++E A+PGAR+ LP A DPDVGVNSLQSYQLSPN++FSL ++   +GA NP
Sbjct: 133 FQAESLEVKINEIAVPGARYPLPEAIDPDVGVNSLQSYQLSPNHHFSLNVQTGDNGAINP 192

Query: 194 ELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVP 253
           ELVLE +LDRE+  AH L+LTA DGG+P R   V I V VLD ND+ P+F Q +YRV V 
Sbjct: 193 ELVLERALDREEATAHHLVLTASDGGEPRRSSTVRIHVTVLDTNDNAPVFAQRIYRVKVL 252

Query: 254 ENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGEVQVRGSLDFEKY 313
           EN+  GT +L   A+D DEGING+V Y F  +  K S +FQL+  TGE+    SLD+E+ 
Sbjct: 253 ENVPPGTWLLTATASDLDEGINGKVAYKFWKINEKQSLLFQLNENTGEISTAKSLDYEEC 312

Query: 314 RFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILENSPPGTVIALLNVQ 373
            FYEMEIQ +DGGGL   T +LI+V DVNDN PE+TITS  + + E++P GTVI L N  
Sbjct: 313 SFYEMEIQAEDGGGLKGWTKVLISVEDVNDNRPEVTITSLFSPVREDAPQGTVILLFNAH 372

Query: 374 DQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDRELVQSYNITLTATDQGSPPL 433
           D+DSG+NGQV C I  +L F LE +  +YY+L+T+++LDRE    YNIT+TATD+G+PPL
Sbjct: 373 DRDSGKNGQVVCSIQENLSFTLENSEEDYYRLLTAQILDREKASEYNITVTATDRGTPPL 432

Query: 434 SAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDSKQNALVTYSLT 493
           S E H+ L V D NDNPP F  +SYS Y+PENN RG SIFSV A DPDS +N+ V YSL 
Sbjct: 433 STEIHITLQVTDINDNPPAFSQASYSVYLPENNARGTSIFSVIAYDPDSNENSRVIYSLA 492

Query: 494 DDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFV 553
           +DT+QG PLS+YVSINS+TGVLYAL SFDYEQFRDL+++V A DSG PPLSSNVSL LFV
Sbjct: 493 EDTIQGSPLSTYVSINSDTGVLYALCSFDYEQFRDLQMQVTASDSGSPPLSSNVSLRLFV 552

Query: 554 LDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKAS 613
           LDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVD+DSGQNAWLSYRL KAS
Sbjct: 553 LDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLFKAS 612

Query: 614 EPGLFAVGEHTGE 626
           EPGLF+VG HTGE
Sbjct: 613 EPGLFSVGLHTGE 625



 Score =  155 bits (392), Expect = 1e-37
 Identities = 160/559 (28%), Positives = 248/559 (44%), Gaps = 64/559 (11%)

Query: 33  RYSVPEETEKGSFVGNISKDLGLEPRELAKRGVRIVSRGKTQLFAVNPRSGSLITAGRID 92
           RY +PE  +    V ++ +   L P       V+    G     A+NP    L+    +D
Sbjct: 151 RYPLPEAIDPDVGVNSL-QSYQLSPNHHFSLNVQTGDNG-----AINPE---LVLERALD 201

Query: 93  REELC--ETVSSCFLNMELLVEDTLKIYGVEVEIIDINDNAPSFQEDEVEIKVSEHAIPG 150
           REE      V +     E     T++I+   V ++D NDNAP F +    +KV E+  PG
Sbjct: 202 REEATAHHLVLTASDGGEPRRSSTVRIH---VTVLDTNDNAPVFAQRIYRVKVLENVPPG 258

Query: 151 ARFALPNARDPDVGVNSLQSYQ---LSPNNYFSLQLRGRTDGAKNPELVLEGSLDREKEA 207
                  A D D G+N   +Y+   ++       QL   T      E+    SLD E+ +
Sbjct: 259 TWLLTATASDLDEGINGKVAYKFWKINEKQSLLFQLNENTG-----EISTAKSLDYEECS 313

Query: 208 AHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVPENISSGTRVLMVNA 267
            + + + A DGG    KG   + + V DVND+ P  T +     V E+   GT +L+ NA
Sbjct: 314 FYEMEIQAEDGGG--LKGWTKVLISVEDVNDNRPEVTITSLFSPVREDAPQGTVILLFNA 371

Query: 268 TDPDEGINGEVMYSFRN-----MESKASEIFQLDSQTGEVQVRGSLDFEKYRFYEMEIQG 322
            D D G NG+V+ S +      +E+   + ++L   T ++     LD EK   Y + +  
Sbjct: 372 HDRDSGKNGQVVCSIQENLSFTLENSEEDYYRL--LTAQI-----LDREKASEYNITVTA 424

Query: 323 QDGGGLFTTTTMLIT--VVDVNDNAPEITITSSINSILENSPPGTVIALLNVQDQDSGEN 380
            D G    +T + IT  V D+NDN P  +  S    + EN+  GT I  +   D DS EN
Sbjct: 425 TDRGTPPLSTEIHITLQVTDINDNPPAFSQASYSVYLPENNARGTSIFSVIAYDPDSNEN 484

Query: 381 GQVSCFI--------PNHLPFKLEKTYGNYYKLITSRVLDRELVQSYNITLTATDQGSPP 432
            +V   +        P      +    G  Y L +    D E  +   + +TA+D GSPP
Sbjct: 485 SRVIYSLAEDTIQGSPLSTYVSINSDTGVLYALCS---FDYEQFRDLQMQVTASDSGSPP 541

Query: 433 LSAETHVWLNVADDNDNPP--VFPH-----SSYSAYIPENNPRGASIFSVTALDPDSKQN 485
           LS+   + L V D NDN P  ++P      S+     P +   G  +  V A+D DS QN
Sbjct: 542 LSSNVSLRLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQN 601

Query: 486 ALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPPLSS 545
           A ++Y L   +  G+      S+  +TG +   ++          L V  +D G PPLS+
Sbjct: 602 AWLSYRLFKASEPGL-----FSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSA 656

Query: 546 NVSLSLFVLDQNDNAPEIL 564
            V+L++ +    D+ P+IL
Sbjct: 657 TVTLTVAIA---DSIPDIL 672


>gi|11056030 protocadherin gamma subfamily A, 2 isoform 1 precursor
           [Homo sapiens]
          Length = 932

 Score =  798 bits (2061), Expect = 0.0
 Identities = 403/622 (64%), Positives = 479/622 (77%)

Query: 5   LQRGDRSRLLLLLCIFLGTLRGFRARQIRYSVPEETEKGSFVGNISKDLGLEPRELAKRG 64
           LQ+    R L+LLC  L TL   RA QIRYSV EE ++GSFVGNI+KDLGLEP  LA++G
Sbjct: 4   LQKLPHCRKLVLLCFLLATLWEARAGQIRYSVREEIDRGSFVGNIAKDLGLEPLALAEQG 63

Query: 65  VRIVSRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEI 124
           VRIVSRG++QLFA+NPRSGSL+TA RIDREELC   + C LN  +L+ED L IY VEVEI
Sbjct: 64  VRIVSRGRSQLFALNPRSGSLVTANRIDREELCAQSAPCLLNFNILLEDKLTIYSVEVEI 123

Query: 125 IDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLR 184
            DINDNAP F  +E+E+K+SE   PG R  L NA D DVG N+LQ Y L+PN++FSL +R
Sbjct: 124 TDINDNAPRFGVEELELKISETTTPGFRIPLKNAHDADVGENALQKYALNPNDHFSLDVR 183

Query: 185 GRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFT 244
              DG K PELVLE SLDRE+EA H L+L A DGGDP+  G   I V VLD ND+ P+FT
Sbjct: 184 RGADGNKYPELVLERSLDREEEAVHHLVLVASDGGDPVLSGTSRICVKVLDANDNAPVFT 243

Query: 245 QSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGEVQV 304
           Q  YR+S+PEN   GTR+L V ATD DEG   +V+Y       + SE+F+L S +GE+ +
Sbjct: 244 QPEYRISIPENTLVGTRILTVTATDADEGYYAQVVYFLEKSPGETSEVFELKSTSGELTI 303

Query: 305 RGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILENSPPG 364
              LD+E   F+E++I+ QDG GL T   +++TV+DVNDNAPE  +TS+ +S+ E+S PG
Sbjct: 304 IKDLDYEDATFHEIDIEAQDGPGLLTRAKVIVTVLDVNDNAPEFYMTSATSSVSEDSLPG 363

Query: 365 TVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDRELVQSYNITLT 424
           T+I L NV D+DSG+N   +C +P  LPFKLEK+  NYY+L+T+R LDRE    YNITLT
Sbjct: 364 TIIGLFNVHDRDSGQNAFTTCSLPEDLPFKLEKSVDNYYRLVTTRALDREQFSFYNITLT 423

Query: 425 ATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDSKQ 484
           A D G+P LS + H+ L VAD NDN P F  +SYS YIPENNPRGAS+FSVTA DPDS  
Sbjct: 424 AKDGGNPSLSTDAHILLQVADINDNAPAFSRTSYSTYIPENNPRGASVFSVTAHDPDSND 483

Query: 485 NALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPPLS 544
           NA VTYS  +DTVQG PLSSY+SINS+TGVLYAL+SFDYEQ RDL++ VIARDSG+PPLS
Sbjct: 484 NAHVTYSFAEDTVQGAPLSSYISINSDTGVLYALRSFDYEQLRDLQVWVIARDSGNPPLS 543

Query: 545 SNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAW 604
           SNVSLSLFVLDQNDNAPEILYPA PTDGSTGVELAPRSAEPGYLVTKVVAVD+DSGQNAW
Sbjct: 544 SNVSLSLFVLDQNDNAPEILYPAFPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAW 603

Query: 605 LSYRLLKASEPGLFAVGEHTGE 626
           LSY LLKASEPGLF+VG HTGE
Sbjct: 604 LSYHLLKASEPGLFSVGLHTGE 625



 Score =  259 bits (663), Expect = 5e-69
 Identities = 125/129 (96%), Positives = 126/129 (97%)

Query: 622 EHTGEQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGS 681
           E   +QAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGS
Sbjct: 804 ETFSQQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGS 863

Query: 682 STLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNK 741
           STLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNK
Sbjct: 864 STLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNK 923

Query: 742 KKSGKKEKK 750
           KKSGKKEKK
Sbjct: 924 KKSGKKEKK 932



 Score =  163 bits (413), Expect = 5e-40
 Identities = 152/519 (29%), Positives = 225/519 (43%), Gaps = 47/519 (9%)

Query: 122 VEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQL--SPNNYF 179
           V+++D NDNAP F + E  I + E+ + G R     A D D G  +   Y L  SP    
Sbjct: 230 VKVLDANDNAPVFTQPEYRISIPENTLVGTRILTVTATDADEGYYAQVVYFLEKSPGETS 289

Query: 180 SLQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDH 239
            +     T G    EL +   LD E    H + + A DG   + +  V   V VLDVND+
Sbjct: 290 EVFELKSTSG----ELTIIKDLDYEDATFHEIDIEAQDGPGLLTRAKVI--VTVLDVNDN 343

Query: 240 IPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSF-RNMESKASEIFQLDSQ 298
            P F  +    SV E+   GT + + N  D D G N     S   ++  K  +   +D+ 
Sbjct: 344 APEFYMTSATSSVSEDSLPGTIIGLFNVHDRDSGQNAFTTCSLPEDLPFKLEK--SVDNY 401

Query: 299 TGEVQVRGSLDFEKYRFYEMEIQGQDGGG--LFTTTTMLITVVDVNDNAPEITITSSINS 356
              V  R +LD E++ FY + +  +DGG   L T   +L+ V D+NDNAP  + TS    
Sbjct: 402 YRLVTTR-ALDREQFSFYNITLTAKDGGNPSLSTDAHILLQVADINDNAPAFSRTSYSTY 460

Query: 357 ILENSPPGTVIALLNVQDQDSGENGQVSCFI--------PNHLPFKLEKTYGNYYKLITS 408
           I EN+P G  +  +   D DS +N  V+           P      +    G  Y L   
Sbjct: 461 IPENNPRGASVFSVTAHDPDSNDNAHVTYSFAEDTVQGAPLSSYISINSDTGVLYAL--- 517

Query: 409 RVLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSA-------Y 461
           R  D E ++   + + A D G+PPLS+   + L V D NDN P   + ++          
Sbjct: 518 RSFDYEQLRDLQVWVIARDSGNPPLSSNVSLSLFVLDQNDNAPEILYPAFPTDGSTGVEL 577

Query: 462 IPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSF 521
            P +   G  +  V A+D DS QNA ++Y L   +  G+      S+  +TG +   ++ 
Sbjct: 578 APRSAEPGYLVTKVVAVDRDSGQNAWLSYHLLKASEPGL-----FSVGLHTGEVRTARAL 632

Query: 522 DYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILY-------PALPTDGST 574
                    L V  +D G PPLS+ V+L++ V D+    P+IL         A+P D   
Sbjct: 633 LDRDALKQSLVVAIQDHGQPPLSATVTLTVAVADR---IPDILADLGSLEPSAIPNDSDL 689

Query: 575 GVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKAS 613
            + L    A    +    V V        W   RLL+AS
Sbjct: 690 TLYLVVAVAAVSCVFLAFVIVLLAHRLRRWHKSRLLQAS 728


>gi|14196462 protocadherin gamma subfamily A, 2 isoform 2 precursor
           [Homo sapiens]
          Length = 823

 Score =  798 bits (2061), Expect = 0.0
 Identities = 403/622 (64%), Positives = 479/622 (77%)

Query: 5   LQRGDRSRLLLLLCIFLGTLRGFRARQIRYSVPEETEKGSFVGNISKDLGLEPRELAKRG 64
           LQ+    R L+LLC  L TL   RA QIRYSV EE ++GSFVGNI+KDLGLEP  LA++G
Sbjct: 4   LQKLPHCRKLVLLCFLLATLWEARAGQIRYSVREEIDRGSFVGNIAKDLGLEPLALAEQG 63

Query: 65  VRIVSRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEI 124
           VRIVSRG++QLFA+NPRSGSL+TA RIDREELC   + C LN  +L+ED L IY VEVEI
Sbjct: 64  VRIVSRGRSQLFALNPRSGSLVTANRIDREELCAQSAPCLLNFNILLEDKLTIYSVEVEI 123

Query: 125 IDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLR 184
            DINDNAP F  +E+E+K+SE   PG R  L NA D DVG N+LQ Y L+PN++FSL +R
Sbjct: 124 TDINDNAPRFGVEELELKISETTTPGFRIPLKNAHDADVGENALQKYALNPNDHFSLDVR 183

Query: 185 GRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFT 244
              DG K PELVLE SLDRE+EA H L+L A DGGDP+  G   I V VLD ND+ P+FT
Sbjct: 184 RGADGNKYPELVLERSLDREEEAVHHLVLVASDGGDPVLSGTSRICVKVLDANDNAPVFT 243

Query: 245 QSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGEVQV 304
           Q  YR+S+PEN   GTR+L V ATD DEG   +V+Y       + SE+F+L S +GE+ +
Sbjct: 244 QPEYRISIPENTLVGTRILTVTATDADEGYYAQVVYFLEKSPGETSEVFELKSTSGELTI 303

Query: 305 RGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILENSPPG 364
              LD+E   F+E++I+ QDG GL T   +++TV+DVNDNAPE  +TS+ +S+ E+S PG
Sbjct: 304 IKDLDYEDATFHEIDIEAQDGPGLLTRAKVIVTVLDVNDNAPEFYMTSATSSVSEDSLPG 363

Query: 365 TVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDRELVQSYNITLT 424
           T+I L NV D+DSG+N   +C +P  LPFKLEK+  NYY+L+T+R LDRE    YNITLT
Sbjct: 364 TIIGLFNVHDRDSGQNAFTTCSLPEDLPFKLEKSVDNYYRLVTTRALDREQFSFYNITLT 423

Query: 425 ATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDSKQ 484
           A D G+P LS + H+ L VAD NDN P F  +SYS YIPENNPRGAS+FSVTA DPDS  
Sbjct: 424 AKDGGNPSLSTDAHILLQVADINDNAPAFSRTSYSTYIPENNPRGASVFSVTAHDPDSND 483

Query: 485 NALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPPLS 544
           NA VTYS  +DTVQG PLSSY+SINS+TGVLYAL+SFDYEQ RDL++ VIARDSG+PPLS
Sbjct: 484 NAHVTYSFAEDTVQGAPLSSYISINSDTGVLYALRSFDYEQLRDLQVWVIARDSGNPPLS 543

Query: 545 SNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAW 604
           SNVSLSLFVLDQNDNAPEILYPA PTDGSTGVELAPRSAEPGYLVTKVVAVD+DSGQNAW
Sbjct: 544 SNVSLSLFVLDQNDNAPEILYPAFPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAW 603

Query: 605 LSYRLLKASEPGLFAVGEHTGE 626
           LSY LLKASEPGLF+VG HTGE
Sbjct: 604 LSYHLLKASEPGLFSVGLHTGE 625



 Score =  163 bits (413), Expect = 5e-40
 Identities = 152/519 (29%), Positives = 225/519 (43%), Gaps = 47/519 (9%)

Query: 122 VEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQL--SPNNYF 179
           V+++D NDNAP F + E  I + E+ + G R     A D D G  +   Y L  SP    
Sbjct: 230 VKVLDANDNAPVFTQPEYRISIPENTLVGTRILTVTATDADEGYYAQVVYFLEKSPGETS 289

Query: 180 SLQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDH 239
            +     T G    EL +   LD E    H + + A DG   + +  V   V VLDVND+
Sbjct: 290 EVFELKSTSG----ELTIIKDLDYEDATFHEIDIEAQDGPGLLTRAKVI--VTVLDVNDN 343

Query: 240 IPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSF-RNMESKASEIFQLDSQ 298
            P F  +    SV E+   GT + + N  D D G N     S   ++  K  +   +D+ 
Sbjct: 344 APEFYMTSATSSVSEDSLPGTIIGLFNVHDRDSGQNAFTTCSLPEDLPFKLEK--SVDNY 401

Query: 299 TGEVQVRGSLDFEKYRFYEMEIQGQDGGG--LFTTTTMLITVVDVNDNAPEITITSSINS 356
              V  R +LD E++ FY + +  +DGG   L T   +L+ V D+NDNAP  + TS    
Sbjct: 402 YRLVTTR-ALDREQFSFYNITLTAKDGGNPSLSTDAHILLQVADINDNAPAFSRTSYSTY 460

Query: 357 ILENSPPGTVIALLNVQDQDSGENGQVSCFI--------PNHLPFKLEKTYGNYYKLITS 408
           I EN+P G  +  +   D DS +N  V+           P      +    G  Y L   
Sbjct: 461 IPENNPRGASVFSVTAHDPDSNDNAHVTYSFAEDTVQGAPLSSYISINSDTGVLYAL--- 517

Query: 409 RVLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSA-------Y 461
           R  D E ++   + + A D G+PPLS+   + L V D NDN P   + ++          
Sbjct: 518 RSFDYEQLRDLQVWVIARDSGNPPLSSNVSLSLFVLDQNDNAPEILYPAFPTDGSTGVEL 577

Query: 462 IPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSF 521
            P +   G  +  V A+D DS QNA ++Y L   +  G+      S+  +TG +   ++ 
Sbjct: 578 APRSAEPGYLVTKVVAVDRDSGQNAWLSYHLLKASEPGL-----FSVGLHTGEVRTARAL 632

Query: 522 DYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILY-------PALPTDGST 574
                    L V  +D G PPLS+ V+L++ V D+    P+IL         A+P D   
Sbjct: 633 LDRDALKQSLVVAIQDHGQPPLSATVTLTVAVADR---IPDILADLGSLEPSAIPNDSDL 689

Query: 575 GVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKAS 613
            + L    A    +    V V        W   RLL+AS
Sbjct: 690 TLYLVVAVAAVSCVFLAFVIVLLAHRLRRWHKSRLLQAS 728


>gi|14270508 protocadherin gamma subfamily B, 7 isoform 2 precursor
           [Homo sapiens]
          Length = 808

 Score =  613 bits (1582), Expect = e-175
 Identities = 318/626 (50%), Positives = 425/626 (67%), Gaps = 7/626 (1%)

Query: 2   ANRLQRGDRSRLL-LLLCIFLGTLRGFRARQIRYSVPEETEKGSFVGNISKDLGLEPREL 60
           A R + G R  L  LLL +F  TL       IRYS+PEE  KGS VGN++KDLGL   ++
Sbjct: 6   AQRRRAGPRQVLFPLLLPLFYPTL----CEPIRYSIPEELAKGSVVGNLAKDLGLSVLDV 61

Query: 61  AKRGVRIVSRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGV 120
           + R +R VS  K   F+V+ +SG L+   RIDRE++C+    C L +E +VE+ L I+ V
Sbjct: 62  SARELR-VSAEKLH-FSVDAQSGDLLVKDRIDREQICKERRRCELQLEAVVENPLNIFHV 119

Query: 121 EVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFS 180
            V I D+ND+AP F++DE+ +++SE    G    L +A DPD+ +NSL  YQLSPN YFS
Sbjct: 120 IVVIEDVNDHAPQFRKDEINLEISESVSLGMGTILESAEDPDISMNSLSKYQLSPNEYFS 179

Query: 181 LQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHI 240
           L  +   DG K PELVL+ +LDRE ++AH L+LTALDGGDP R G   IR++V+D ND+ 
Sbjct: 180 LVEKDNPDGGKYPELVLQKTLDRETQSAHHLVLTALDGGDPPRSGTAQIRILVIDANDNP 239

Query: 241 PMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTG 300
           P+F+Q VYRVS+ E++  GT +L V ATD DEGIN E+ YSF  +  KA  +F LD  TG
Sbjct: 240 PVFSQDVYRVSLREDVPPGTSILRVKATDQDEGINSEITYSFFGVADKAQHVFSLDYTTG 299

Query: 301 EVQVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILEN 360
            +  +  LDFE+   Y + I+ +D G L T   +++ VVD NDN+PEI ITS  + I+E+
Sbjct: 300 NILTQQPLDFEEVERYTINIEAKDRGSLSTRCKVIVEVVDENDNSPEIIITSLSDQIMED 359

Query: 361 SPPGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDRELVQSYN 420
           SPPG V+AL   +DQDSGENG+V C +   +PFK+  +  NYYKL+T   LDRE    YN
Sbjct: 360 SPPGVVVALFKTRDQDSGENGEVRCSLSRGVPFKIHSSSNNYYKLVTDEALDREQTPEYN 419

Query: 421 ITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDP 480
           +T+ ATD+G PPLS+   + L++ D NDN PVF  S+Y  ++PENN  GASI  V+A DP
Sbjct: 420 VTIAATDRGKPPLSSSKTITLHITDVNDNAPVFGQSAYLVHVPENNQPGASIAQVSASDP 479

Query: 481 DSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGD 540
           D   N  V+YSL    ++   LSSYVS+++ +GV++A ++FD+EQ R  EL + ARD G 
Sbjct: 480 DFGLNGRVSYSLIASDLESRTLSSYVSVSAQSGVVFAQRAFDHEQLRTFELTLQARDQGS 539

Query: 541 PPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSG 600
           P LS+NVSL + V D+NDNAP +LYPAL  DGS   +  PR+A+PGYLVTKVVAVD DSG
Sbjct: 540 PALSANVSLRVLVGDRNDNAPRVLYPALGPDGSALFDTVPRAAQPGYLVTKVVAVDADSG 599

Query: 601 QNAWLSYRLLKASEPGLFAVGEHTGE 626
            NAWLSY +++ASEPGLF++G  TGE
Sbjct: 600 HNAWLSYHVVQASEPGLFSLGLRTGE 625



 Score =  148 bits (373), Expect = 2e-35
 Identities = 132/483 (27%), Positives = 213/483 (44%), Gaps = 46/483 (9%)

Query: 120 VEVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQL-----S 174
           + + +ID NDN P F +D   + + E   PG       A D D G+NS  +Y        
Sbjct: 228 IRILVIDANDNPPVFSQDVYRVSLREDVPPGTSILRVKATDQDEGINSEITYSFFGVADK 287

Query: 175 PNNYFSLQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVL 234
             + FSL     T G     ++ +  LD E+   + + + A D G    +  V + VV  
Sbjct: 288 AQHVFSLDY---TTG----NILTQQPLDFEEVERYTINIEAKDRGSLSTRCKVIVEVV-- 338

Query: 235 DVNDHIPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRN-----MESKA 289
           D ND+ P    +     + E+   G  V +    D D G NGEV  S        + S +
Sbjct: 339 DENDNSPEIIITSLSDQIMEDSPPGVVVALFKTRDQDSGENGEVRCSLSRGVPFKIHSSS 398

Query: 290 SEIFQLDSQTGEVQVRGSLDFEKYRFYEMEIQGQDGGG--LFTTTTMLITVVDVNDNAPE 347
           +  ++L +         +LD E+   Y + I   D G   L ++ T+ + + DVNDNAP 
Sbjct: 399 NNYYKLVTDE-------ALDREQTPEYNVTIAATDRGKPPLSSSKTITLHITDVNDNAPV 451

Query: 348 ITITSSINSILENSPPGTVIALLNVQDQDSGENGQVS-CFIPNHLPFKLEKTYGNYYK-- 404
              ++ +  + EN+ PG  IA ++  D D G NG+VS   I + L  +   +Y +     
Sbjct: 452 FGQSAYLVHVPENNQPGASIAQVSASDPDFGLNGRVSYSLIASDLESRTLSSYVSVSAQS 511

Query: 405 --LITSRVLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPP--VFPH----- 455
             +   R  D E ++++ +TL A DQGSP LSA   + + V D NDN P  ++P      
Sbjct: 512 GVVFAQRAFDHEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPRVLYPALGPDG 571

Query: 456 SSYSAYIPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVL 515
           S+    +P     G  +  V A+D DS  NA ++Y +   +  G+      S+   TG +
Sbjct: 572 SALFDTVPRAAQPGYLVTKVVAVDADSGHNAWLSYHVVQASEPGL-----FSLGLRTGEV 626

Query: 516 YALQSFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQ-NDNAPEILYPALPTDGST 574
             +++   +      L V  RD G PPLS+  +L L   D   +  P+      P+D   
Sbjct: 627 RMVRALGDKDSVRQRLLVAVRDGGQPPLSATATLHLVFADSLQEVLPDFSDHPTPSDSQA 686

Query: 575 GVE 577
            ++
Sbjct: 687 EMQ 689


>gi|11128027 protocadherin gamma subfamily B, 7 isoform 1 precursor
           [Homo sapiens]
          Length = 929

 Score =  613 bits (1582), Expect = e-175
 Identities = 318/626 (50%), Positives = 425/626 (67%), Gaps = 7/626 (1%)

Query: 2   ANRLQRGDRSRLL-LLLCIFLGTLRGFRARQIRYSVPEETEKGSFVGNISKDLGLEPREL 60
           A R + G R  L  LLL +F  TL       IRYS+PEE  KGS VGN++KDLGL   ++
Sbjct: 6   AQRRRAGPRQVLFPLLLPLFYPTL----CEPIRYSIPEELAKGSVVGNLAKDLGLSVLDV 61

Query: 61  AKRGVRIVSRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGV 120
           + R +R VS  K   F+V+ +SG L+   RIDRE++C+    C L +E +VE+ L I+ V
Sbjct: 62  SARELR-VSAEKLH-FSVDAQSGDLLVKDRIDREQICKERRRCELQLEAVVENPLNIFHV 119

Query: 121 EVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFS 180
            V I D+ND+AP F++DE+ +++SE    G    L +A DPD+ +NSL  YQLSPN YFS
Sbjct: 120 IVVIEDVNDHAPQFRKDEINLEISESVSLGMGTILESAEDPDISMNSLSKYQLSPNEYFS 179

Query: 181 LQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHI 240
           L  +   DG K PELVL+ +LDRE ++AH L+LTALDGGDP R G   IR++V+D ND+ 
Sbjct: 180 LVEKDNPDGGKYPELVLQKTLDRETQSAHHLVLTALDGGDPPRSGTAQIRILVIDANDNP 239

Query: 241 PMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTG 300
           P+F+Q VYRVS+ E++  GT +L V ATD DEGIN E+ YSF  +  KA  +F LD  TG
Sbjct: 240 PVFSQDVYRVSLREDVPPGTSILRVKATDQDEGINSEITYSFFGVADKAQHVFSLDYTTG 299

Query: 301 EVQVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILEN 360
            +  +  LDFE+   Y + I+ +D G L T   +++ VVD NDN+PEI ITS  + I+E+
Sbjct: 300 NILTQQPLDFEEVERYTINIEAKDRGSLSTRCKVIVEVVDENDNSPEIIITSLSDQIMED 359

Query: 361 SPPGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDRELVQSYN 420
           SPPG V+AL   +DQDSGENG+V C +   +PFK+  +  NYYKL+T   LDRE    YN
Sbjct: 360 SPPGVVVALFKTRDQDSGENGEVRCSLSRGVPFKIHSSSNNYYKLVTDEALDREQTPEYN 419

Query: 421 ITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDP 480
           +T+ ATD+G PPLS+   + L++ D NDN PVF  S+Y  ++PENN  GASI  V+A DP
Sbjct: 420 VTIAATDRGKPPLSSSKTITLHITDVNDNAPVFGQSAYLVHVPENNQPGASIAQVSASDP 479

Query: 481 DSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGD 540
           D   N  V+YSL    ++   LSSYVS+++ +GV++A ++FD+EQ R  EL + ARD G 
Sbjct: 480 DFGLNGRVSYSLIASDLESRTLSSYVSVSAQSGVVFAQRAFDHEQLRTFELTLQARDQGS 539

Query: 541 PPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSG 600
           P LS+NVSL + V D+NDNAP +LYPAL  DGS   +  PR+A+PGYLVTKVVAVD DSG
Sbjct: 540 PALSANVSLRVLVGDRNDNAPRVLYPALGPDGSALFDTVPRAAQPGYLVTKVVAVDADSG 599

Query: 601 QNAWLSYRLLKASEPGLFAVGEHTGE 626
            NAWLSY +++ASEPGLF++G  TGE
Sbjct: 600 HNAWLSYHVVQASEPGLFSLGLRTGE 625



 Score =  371 bits (953), Expect = e-102
 Identities = 270/697 (38%), Positives = 365/697 (52%), Gaps = 79/697 (11%)

Query: 75  LFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIY-GVEVEIIDINDNAPS 133
           +F+++  +G+++T   +D EE    V    +N+E     +L     V VE++D NDN+P 
Sbjct: 291 VFSLDYTTGNILTQQPLDFEE----VERYTINIEAKDRGSLSTRCKVIVEVVDENDNSPE 346

Query: 134 FQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGAKNP 193
                +  ++ E + PG   AL   RD D G N      LS    F +     +      
Sbjct: 347 IIITSLSDQIMEDSPPGVVVALFKTRDQDSGENGEVRCSLSRGVPFKIH----SSSNNYY 402

Query: 194 ELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVP 253
           +LV + +LDRE+   + + + A D G P    +  I + + DVND+ P+F QS Y V VP
Sbjct: 403 KLVTDEALDREQTPEYNVTIAATDRGKPPLSSSKTITLHITDVNDNAPVFGQSAYLVHVP 462

Query: 254 ENISSGTRVLMVNATDPDEGINGEVMYSF--RNMESKA-SEIFQLDSQTGEVQVRGSLDF 310
           EN   G  +  V+A+DPD G+NG V YS    ++ES+  S    + +Q+G V  + + D 
Sbjct: 463 ENNQPGASIAQVSASDPDFGLNGRVSYSLIASDLESRTLSSYVSVSAQSGVVFAQRAFDH 522

Query: 311 EKYRFYEMEIQGQDGGG--LFTTTTMLITVVDVNDNAPEITI-------TSSINSILENS 361
           E+ R +E+ +Q +D G   L    ++ + V D NDNAP +         ++  +++   +
Sbjct: 523 EQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPRVLYPALGPDGSALFDTVPRAA 582

Query: 362 PPGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVL-DRELVQSYN 420
            PG ++  +   D DSG N  +S  +       L        ++   R L D++ V+   
Sbjct: 583 QPGYLVTKVVAVDADSGHNAWLSYHVVQASEPGLFSLGLRTGEVRMVRALGDKDSVRQ-R 641

Query: 421 ITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDP 480
           + +   D G PPLSA   + L  AD      V P  S     P ++      + V AL  
Sbjct: 642 LLVAVRDGGQPPLSATATLHLVFADSLQE--VLPDFSDHP-TPSDSQAEMQFYLVVAL-- 696

Query: 481 DSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGD 540
                AL++       +  + L    S +   G              D    V+   SG 
Sbjct: 697 -----ALISVLFLLAVILAIALRLRQSFSPTAG--------------DCFESVLCSKSGP 737

Query: 541 --PPLSSNVSLSL---FVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAV 595
             PP  S  +L     F +  +   PE  +        T V+  P + +          +
Sbjct: 738 VGPPNYSEGTLPYAYNFCVPGDQMNPEFNF-------FTSVDHCPATQDN---------L 781

Query: 596 DKDSGQNAWLSYRLLKAS--EPGLFAVGEHTGEQAPPNTDWRFSQAQRPGTSGSQNGDDT 653
           +KDS         +L AS   P + A  +   +QAPPNTDWRFSQAQRPGTSGSQNGDDT
Sbjct: 782 NKDS---------MLLASILTPSVEADKKILKQQAPPNTDWRFSQAQRPGTSGSQNGDDT 832

Query: 654 GTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNV 713
           GTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNV
Sbjct: 833 GTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNV 892

Query: 714 YIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK 750
           YIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK
Sbjct: 893 YIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK 929



 Score =  148 bits (373), Expect = 2e-35
 Identities = 132/483 (27%), Positives = 213/483 (44%), Gaps = 46/483 (9%)

Query: 120 VEVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQL-----S 174
           + + +ID NDN P F +D   + + E   PG       A D D G+NS  +Y        
Sbjct: 228 IRILVIDANDNPPVFSQDVYRVSLREDVPPGTSILRVKATDQDEGINSEITYSFFGVADK 287

Query: 175 PNNYFSLQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVL 234
             + FSL     T G     ++ +  LD E+   + + + A D G    +  V + VV  
Sbjct: 288 AQHVFSLDY---TTG----NILTQQPLDFEEVERYTINIEAKDRGSLSTRCKVIVEVV-- 338

Query: 235 DVNDHIPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRN-----MESKA 289
           D ND+ P    +     + E+   G  V +    D D G NGEV  S        + S +
Sbjct: 339 DENDNSPEIIITSLSDQIMEDSPPGVVVALFKTRDQDSGENGEVRCSLSRGVPFKIHSSS 398

Query: 290 SEIFQLDSQTGEVQVRGSLDFEKYRFYEMEIQGQDGGG--LFTTTTMLITVVDVNDNAPE 347
           +  ++L +         +LD E+   Y + I   D G   L ++ T+ + + DVNDNAP 
Sbjct: 399 NNYYKLVTDE-------ALDREQTPEYNVTIAATDRGKPPLSSSKTITLHITDVNDNAPV 451

Query: 348 ITITSSINSILENSPPGTVIALLNVQDQDSGENGQVS-CFIPNHLPFKLEKTYGNYYK-- 404
              ++ +  + EN+ PG  IA ++  D D G NG+VS   I + L  +   +Y +     
Sbjct: 452 FGQSAYLVHVPENNQPGASIAQVSASDPDFGLNGRVSYSLIASDLESRTLSSYVSVSAQS 511

Query: 405 --LITSRVLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPP--VFPH----- 455
             +   R  D E ++++ +TL A DQGSP LSA   + + V D NDN P  ++P      
Sbjct: 512 GVVFAQRAFDHEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPRVLYPALGPDG 571

Query: 456 SSYSAYIPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVL 515
           S+    +P     G  +  V A+D DS  NA ++Y +   +  G+      S+   TG +
Sbjct: 572 SALFDTVPRAAQPGYLVTKVVAVDADSGHNAWLSYHVVQASEPGL-----FSLGLRTGEV 626

Query: 516 YALQSFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQ-NDNAPEILYPALPTDGST 574
             +++   +      L V  RD G PPLS+  +L L   D   +  P+      P+D   
Sbjct: 627 RMVRALGDKDSVRQRLLVAVRDGGQPPLSATATLHLVFADSLQEVLPDFSDHPTPSDSQA 686

Query: 575 GVE 577
            ++
Sbjct: 687 EMQ 689


>gi|14270505 protocadherin gamma subfamily B, 5 isoform 2 precursor
           [Homo sapiens]
          Length = 818

 Score =  602 bits (1552), Expect = e-172
 Identities = 310/619 (50%), Positives = 415/619 (67%), Gaps = 6/619 (0%)

Query: 8   GDRSRLLLLLCIFLGTLRGFRARQIRYSVPEETEKGSFVGNISKDLGLEPRELAKRGVRI 67
           G   RL +L    L         QIRY +PEE  KGS VGN++ DLG   +EL  R +R+
Sbjct: 9   GRAERLPVLFLFLLSLFCPALCEQIRYRIPEEMPKGSVVGNLATDLGFSVQELPTRKLRV 68

Query: 68  VSRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEIIDI 127
            S  +   F V+  SG L+ + R+DREE+C    +C L  E + E+ L  Y V VEI DI
Sbjct: 69  SS--EKPYFTVSAESGELLVSSRLDREEICGKKPACALEFEAVAENPLNFYHVNVEIEDI 126

Query: 128 NDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRT 187
           ND+ P F ++  E+++SE A PG RF L  A D D+G+NSLQ Y+LS N  FSL ++ + 
Sbjct: 127 NDHTPKFTQNSFELQISESAQPGTRFILEVAEDADIGLNSLQKYKLSLNPSFSLIIKEKQ 186

Query: 188 DGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSV 247
           DG+K PEL LE +LDRE+++ H L+LTALDGG P   G   +R+ V D ND+ P+F + V
Sbjct: 187 DGSKYPELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFNRDV 246

Query: 248 YRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGEVQVRGS 307
           YRVS+ EN+  GT VL V+ATD DEGIN E+ YSF     +  +IF L+S++GE+  +  
Sbjct: 247 YRVSLRENVPPGTTVLQVSATDQDEGINSEITYSFY----RTGQIFSLNSKSGEITTQKK 302

Query: 308 LDFEKYRFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILENSPPGTVI 367
           LDFE+ + Y M ++G+DGGGL    T+ I + D NDN+PE+T  S +  ILEN+ PGT+I
Sbjct: 303 LDFEETKEYSMVVEGRDGGGLVAQCTVEINIQDENDNSPEVTFHSLLEMILENAVPGTLI 362

Query: 368 ALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDRELVQSYNITLTATD 427
           AL+ + DQDSGENG+V+C +   +PFK+  +  N YKL+T   LDRE    YN+T+TATD
Sbjct: 363 ALIKIHDQDSGENGEVNCQLQGEVPFKIISSSKNSYKLVTDGTLDREQTPEYNVTITATD 422

Query: 428 QGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDSKQNAL 487
           +G PPLS+   V L++ D NDN PVF  +SY   +PENNP GASI  V A D D   N  
Sbjct: 423 RGKPPLSSSISVILHIRDVNDNAPVFHQASYLVSVPENNPPGASIAQVCASDLDLGLNGQ 482

Query: 488 VTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPPLSSNV 547
           V+YS+    ++ + L+SYVS+++ +GV++A ++FDYEQ R  EL + ARD G P LS+NV
Sbjct: 483 VSYSIMASDLEPLALASYVSMSAQSGVVFAQRAFDYEQLRTFELTLQARDQGSPALSANV 542

Query: 548 SLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSY 607
           SL + V D+NDNAP +LYPAL  DGS   ++ PR+AEPGYLVTKVVAVD DSG NAWLSY
Sbjct: 543 SLRVLVGDRNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSY 602

Query: 608 RLLKASEPGLFAVGEHTGE 626
            +L+ASEPGLF++G  TGE
Sbjct: 603 HVLQASEPGLFSLGLRTGE 621



 Score =  167 bits (424), Expect = 3e-41
 Identities = 153/550 (27%), Positives = 242/550 (44%), Gaps = 59/550 (10%)

Query: 120 VEVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQL-SPNNY 178
           + +++ D NDN P F  D   + + E+  PG      +A D D G+NS  +Y        
Sbjct: 228 LRIQVTDANDNPPVFNRDVYRVSLRENVPPGTTVLQVSATDQDEGINSEITYSFYRTGQI 287

Query: 179 FSLQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVND 238
           FSL        +K+ E+  +  LD E+   + +++   DGG  + +  V I +   D ND
Sbjct: 288 FSLN-------SKSGEITTQKKLDFEETKEYSMVVEGRDGGGLVAQCTVEINIQ--DEND 338

Query: 239 HIPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQ 298
           + P  T       + EN   GT + ++   D D G NGEV    +       +I      
Sbjct: 339 NSPEVTFHSLLEMILENAVPGTLIALIKIHDQDSGENGEVNCQLQG--EVPFKIISSSKN 396

Query: 299 TGEVQVRGSLDFEKYRFYEMEIQGQDGGG--LFTTTTMLITVVDVNDNAPEITITSSINS 356
           + ++   G+LD E+   Y + I   D G   L ++ ++++ + DVNDNAP     S + S
Sbjct: 397 SYKLVTDGTLDREQTPEYNVTITATDRGKPPLSSSISVILHIRDVNDNAPVFHQASYLVS 456

Query: 357 ILENSPPGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEK-TYGNYYKL-------ITS 408
           + EN+PPG  IA +   D D G NGQVS  I   +   LE     +Y  +          
Sbjct: 457 VPENNPPGASIAQVCASDLDLGLNGQVSYSI---MASDLEPLALASYVSMSAQSGVVFAQ 513

Query: 409 RVLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPP--VFPH-----SSYSAY 461
           R  D E ++++ +TL A DQGSP LSA   + + V D NDN P  ++P      S+    
Sbjct: 514 RAFDYEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPRVLYPALGPDGSALFDM 573

Query: 462 IPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSF 521
           +P     G  +  V A+D DS  NA ++Y +   +  G+      S+   TG +   ++ 
Sbjct: 574 VPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGL-----FSLGLRTGEVRTARAL 628

Query: 522 DYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQ-NDNAPEILYPALPTDGSTGVE--- 577
                    L V  RD G PPLS+  +L L   D   +  P+I    +P+D    ++   
Sbjct: 629 GDRDAARQRLLVAVRDGGQPPLSATATLHLVFADSLQEVLPDITDRPVPSDPQAELQFYL 688

Query: 578 -LAPRSAEPGYLVTKVVAV----DKDSGQNAWLSYRLLKASEPGLFAVGEHTGEQAPPNT 632
            +A       +L+  ++AV     + S   AW  +      +PGL      +G   PPN 
Sbjct: 689 VVALALISVLFLLAVILAVALRLRRSSSPAAWSCF------QPGLCV---KSGPVVPPN- 738

Query: 633 DWRFSQAQRP 642
              +SQ   P
Sbjct: 739 ---YSQGTLP 745


>gi|11128031 protocadherin gamma subfamily B, 5 isoform 1 precursor
           [Homo sapiens]
          Length = 923

 Score =  602 bits (1552), Expect = e-172
 Identities = 310/619 (50%), Positives = 415/619 (67%), Gaps = 6/619 (0%)

Query: 8   GDRSRLLLLLCIFLGTLRGFRARQIRYSVPEETEKGSFVGNISKDLGLEPRELAKRGVRI 67
           G   RL +L    L         QIRY +PEE  KGS VGN++ DLG   +EL  R +R+
Sbjct: 9   GRAERLPVLFLFLLSLFCPALCEQIRYRIPEEMPKGSVVGNLATDLGFSVQELPTRKLRV 68

Query: 68  VSRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEIIDI 127
            S  +   F V+  SG L+ + R+DREE+C    +C L  E + E+ L  Y V VEI DI
Sbjct: 69  SS--EKPYFTVSAESGELLVSSRLDREEICGKKPACALEFEAVAENPLNFYHVNVEIEDI 126

Query: 128 NDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRT 187
           ND+ P F ++  E+++SE A PG RF L  A D D+G+NSLQ Y+LS N  FSL ++ + 
Sbjct: 127 NDHTPKFTQNSFELQISESAQPGTRFILEVAEDADIGLNSLQKYKLSLNPSFSLIIKEKQ 186

Query: 188 DGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSV 247
           DG+K PEL LE +LDRE+++ H L+LTALDGG P   G   +R+ V D ND+ P+F + V
Sbjct: 187 DGSKYPELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFNRDV 246

Query: 248 YRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGEVQVRGS 307
           YRVS+ EN+  GT VL V+ATD DEGIN E+ YSF     +  +IF L+S++GE+  +  
Sbjct: 247 YRVSLRENVPPGTTVLQVSATDQDEGINSEITYSFY----RTGQIFSLNSKSGEITTQKK 302

Query: 308 LDFEKYRFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILENSPPGTVI 367
           LDFE+ + Y M ++G+DGGGL    T+ I + D NDN+PE+T  S +  ILEN+ PGT+I
Sbjct: 303 LDFEETKEYSMVVEGRDGGGLVAQCTVEINIQDENDNSPEVTFHSLLEMILENAVPGTLI 362

Query: 368 ALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDRELVQSYNITLTATD 427
           AL+ + DQDSGENG+V+C +   +PFK+  +  N YKL+T   LDRE    YN+T+TATD
Sbjct: 363 ALIKIHDQDSGENGEVNCQLQGEVPFKIISSSKNSYKLVTDGTLDREQTPEYNVTITATD 422

Query: 428 QGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDSKQNAL 487
           +G PPLS+   V L++ D NDN PVF  +SY   +PENNP GASI  V A D D   N  
Sbjct: 423 RGKPPLSSSISVILHIRDVNDNAPVFHQASYLVSVPENNPPGASIAQVCASDLDLGLNGQ 482

Query: 488 VTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPPLSSNV 547
           V+YS+    ++ + L+SYVS+++ +GV++A ++FDYEQ R  EL + ARD G P LS+NV
Sbjct: 483 VSYSIMASDLEPLALASYVSMSAQSGVVFAQRAFDYEQLRTFELTLQARDQGSPALSANV 542

Query: 548 SLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSY 607
           SL + V D+NDNAP +LYPAL  DGS   ++ PR+AEPGYLVTKVVAVD DSG NAWLSY
Sbjct: 543 SLRVLVGDRNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSY 602

Query: 608 RLLKASEPGLFAVGEHTGE 626
            +L+ASEPGLF++G  TGE
Sbjct: 603 HVLQASEPGLFSLGLRTGE 621



 Score =  321 bits (823), Expect = 1e-87
 Identities = 249/724 (34%), Positives = 343/724 (47%), Gaps = 121/724 (16%)

Query: 120 VEVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQL-SPNNY 178
           + +++ D NDN P F  D   + + E+  PG      +A D D G+NS  +Y        
Sbjct: 228 LRIQVTDANDNPPVFNRDVYRVSLRENVPPGTTVLQVSATDQDEGINSEITYSFYRTGQI 287

Query: 179 FSLQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVND 238
           FSL        +K+ E+  +  LD E+   + +++   DGG  + +  V I +   D ND
Sbjct: 288 FSLN-------SKSGEITTQKKLDFEETKEYSMVVEGRDGGGLVAQCTVEINIQ--DEND 338

Query: 239 HIPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQ 298
           + P  T       + EN   GT + ++   D D G NGEV    +       +I      
Sbjct: 339 NSPEVTFHSLLEMILENAVPGTLIALIKIHDQDSGENGEVNCQLQG--EVPFKIISSSKN 396

Query: 299 TGEVQVRGSLDFEKYRFYEMEIQGQDGGG--LFTTTTMLITVVDVNDNAPEITITSSINS 356
           + ++   G+LD E+   Y + I   D G   L ++ ++++ + DVNDNAP     S + S
Sbjct: 397 SYKLVTDGTLDREQTPEYNVTITATDRGKPPLSSSISVILHIRDVNDNAPVFHQASYLVS 456

Query: 357 ILENSPPGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEK-TYGNYYKL-------ITS 408
           + EN+PPG  IA +   D D G NGQVS  I   +   LE     +Y  +          
Sbjct: 457 VPENNPPGASIAQVCASDLDLGLNGQVSYSI---MASDLEPLALASYVSMSAQSGVVFAQ 513

Query: 409 RVLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPP--VFPH-----SSYSAY 461
           R  D E ++++ +TL A DQGSP LSA   + + V D NDN P  ++P      S+    
Sbjct: 514 RAFDYEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPRVLYPALGPDGSALFDM 573

Query: 462 IPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSF 521
           +P     G  +  V A+D DS  NA ++Y +   +  G+      S+   TG +   ++ 
Sbjct: 574 VPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGL-----FSLGLRTGEVRTARAL 628

Query: 522 DYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQ-NDNAPEILYPALPTDGSTGVE--- 577
                    L V  RD G PPLS+  +L L   D   +  P+I    +P+D    ++   
Sbjct: 629 GDRDAARQRLLVAVRDGGQPPLSATATLHLVFADSLQEVLPDITDRPVPSDPQAELQFYL 688

Query: 578 -LAPRSAEPGYLVTKVVAV----DKDSGQNAWLSYRLLKASEPGLFAVGEHTGEQAPPN- 631
            +A       +L+  ++AV     + S   AW  +      +PGL      +G   PPN 
Sbjct: 689 VVALALISVLFLLAVILAVALRLRRSSSPAAWSCF------QPGLCV---KSGPVVPPNY 739

Query: 632 ------------------TDWRFSQAQRPGTSGSQ--NGDDTGT---------------- 655
                             T++ F +     +SG     GD +G                 
Sbjct: 740 SQGTLPYSYNLCVAHTGKTEFNFLKCSEQLSSGQDILCGDSSGALFPLCNSSESTSHPEL 799

Query: 656 -------WPNNQ----------------------FDTEMLQAMILASASEAADGSSTLGG 686
                  W  +Q                      FDTEMLQAMILASASEAADGSSTLGG
Sbjct: 800 QAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGG 859

Query: 687 GAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGK 746
           GAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGK
Sbjct: 860 GAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGK 919

Query: 747 KEKK 750
           KEKK
Sbjct: 920 KEKK 923


>gi|11128029 protocadherin gamma subfamily B, 6 isoform 1 precursor
           [Homo sapiens]
          Length = 930

 Score =  596 bits (1536), Expect = e-170
 Identities = 309/626 (49%), Positives = 418/626 (66%), Gaps = 7/626 (1%)

Query: 2   ANRLQRGDRSRLL-LLLCIFLGTLRGFRARQIRYSVPEETEKGSFVGNISKDLGLEPREL 60
           A R + G R  L  LLL +F  TL    +  IRYS+PEE  KGS VGN++KDLGL   ++
Sbjct: 6   AQRRRAGPRQVLFPLLLPLFYPTL----SEPIRYSIPEELAKGSVVGNLAKDLGLSVLDV 61

Query: 61  AKRGVRIVSRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGV 120
           + R +R VS  K   F+V+  SG L+   RIDRE++C+    C L +E +VE+ L I+ V
Sbjct: 62  SARKLR-VSAEKLH-FSVDAESGDLLVKNRIDREQICKERRRCELQLEAVVENPLNIFHV 119

Query: 121 EVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFS 180
            V I D+ND+AP F + E+ +++ E A  G R +L  A DPD+ +NS++ Y+++ N YFS
Sbjct: 120 IVVIEDVNDHAPQFDKKEIHLEIFESASAGTRLSLDPATDPDININSIKDYKINSNPYFS 179

Query: 181 LQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHI 240
           L +R  +DG K PEL LE  LDRE++ +H L+LTALDGGDP R     I + V D ND+ 
Sbjct: 180 LMVRVNSDGGKYPELSLEKLLDREEQRSHSLILTALDGGDPPRSATAHIEISVKDTNDNP 239

Query: 241 PMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTG 300
           P+F++  YR+S+ EN+  G+ VL V ATD DEG+N E+ Y FR+       +F LD +TG
Sbjct: 240 PVFSRDEYRISLSENLPPGSPVLQVTATDQDEGVNAEINYYFRSTAQSTKHMFSLDEKTG 299

Query: 301 EVQVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILEN 360
            ++   S DFE    Y ME++ +DGGGL T   ++I ++D NDN+PEI ITS  + ILEN
Sbjct: 300 MIKNNQSFDFEDVERYTMEVEAKDGGGLSTQCKVIIEILDENDNSPEIIITSLSDQILEN 359

Query: 361 SPPGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDRELVQSYN 420
           SPPG V+AL   +D D G NG+V C I   +PFK+  +  NYYKL+T   LDRE    YN
Sbjct: 360 SPPGMVVALFKTRDLDFGGNGEVRCNIETDIPFKIYSSSNNYYKLVTDGALDREQTPEYN 419

Query: 421 ITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDP 480
           +T+ ATD+G PPLS+   + L VAD NDN PVF  +SY  ++ ENNP GASI  V+A DP
Sbjct: 420 VTIVATDRGKPPLSSSRSITLYVADINDNAPVFDQTSYVVHVAENNPPGASIAQVSASDP 479

Query: 481 DSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGD 540
           D   N  ++YS+    ++ + +SSYVS+++ +GV++A ++FD+EQ R   L + ARD G 
Sbjct: 480 DLGLNGHISYSIVASDLEPLAVSSYVSVSAQSGVVFAQRAFDHEQLRAFALTLQARDHGS 539

Query: 541 PPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSG 600
           P LS+NVSL + V D+NDNAP +LYPAL  DGS   ++ PRSAEPGYLVTKVVAVD DSG
Sbjct: 540 PTLSANVSLRVLVGDRNDNAPRVLYPALGPDGSAFFDMVPRSAEPGYLVTKVVAVDADSG 599

Query: 601 QNAWLSYRLLKASEPGLFAVGEHTGE 626
            NAWLSY +L+ASEPGLF++G  TGE
Sbjct: 600 HNAWLSYHVLQASEPGLFSLGLRTGE 625



 Score =  258 bits (660), Expect = 1e-68
 Identities = 124/124 (100%), Positives = 124/124 (100%)

Query: 627 QAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGG 686
           QAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGG
Sbjct: 807 QAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGG 866

Query: 687 GAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGK 746
           GAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGK
Sbjct: 867 GAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGK 926

Query: 747 KEKK 750
           KEKK
Sbjct: 927 KEKK 930



 Score =  161 bits (407), Expect = 2e-39
 Identities = 142/468 (30%), Positives = 215/468 (45%), Gaps = 46/468 (9%)

Query: 120 VEVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQL-----S 174
           +E+ + D NDN P F  DE  I +SE+  PG+      A D D GVN+  +Y       S
Sbjct: 228 IEISVKDTNDNPPVFSRDEYRISLSENLPPGSPVLQVTATDQDEGVNAEINYYFRSTAQS 287

Query: 175 PNNYFSLQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVL 234
             + FSL    +T   KN +     S D E    + + + A DGG    +  V I +  L
Sbjct: 288 TKHMFSLD--EKTGMIKNNQ-----SFDFEDVERYTMEVEAKDGGGLSTQCKVIIEI--L 338

Query: 235 DVNDHIPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKAS-EIF 293
           D ND+ P    +     + EN   G  V +    D D G NGEV     N+E+    +I+
Sbjct: 339 DENDNSPEIIITSLSDQILENSPPGMVVALFKTRDLDFGGNGEVRC---NIETDIPFKIY 395

Query: 294 QLDSQTGEVQVRGSLDFEKYRFYEMEIQGQDGGG--LFTTTTMLITVVDVNDNAPEITIT 351
              +   ++   G+LD E+   Y + I   D G   L ++ ++ + V D+NDNAP    T
Sbjct: 396 SSSNNYYKLVTDGALDREQTPEYNVTIVATDRGKPPLSSSRSITLYVADINDNAPVFDQT 455

Query: 352 SSINSILENSPPGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITS--- 408
           S +  + EN+PPG  IA ++  D D G NG +S  I   +   LE    + Y  +++   
Sbjct: 456 SYVVHVAENNPPGASIAQVSASDPDLGLNGHISYSI---VASDLEPLAVSSYVSVSAQSG 512

Query: 409 -----RVLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPP--VFPH-----S 456
                R  D E ++++ +TL A D GSP LSA   + + V D NDN P  ++P      S
Sbjct: 513 VVFAQRAFDHEQLRAFALTLQARDHGSPTLSANVSLRVLVGDRNDNAPRVLYPALGPDGS 572

Query: 457 SYSAYIPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLY 516
           ++   +P +   G  +  V A+D DS  NA ++Y +   +  G+      S+   TG + 
Sbjct: 573 AFFDMVPRSAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGL-----FSLGLRTGEVR 627

Query: 517 ALQSFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEIL 564
             ++          L V  RD G PPLS+  +L L      DN  EIL
Sbjct: 628 TARALGDRDAARQRLLVAVRDGGQPPLSATATLHLVFA---DNLQEIL 672


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.133    0.378 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,129,963
Number of Sequences: 37866
Number of extensions: 1340378
Number of successful extensions: 9242
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 186
Number of HSP's successfully gapped in prelim test: 18
Number of HSP's that attempted gapping in prelim test: 2680
Number of HSP's gapped (non-prelim): 779
length of query: 750
length of database: 18,247,518
effective HSP length: 110
effective length of query: 640
effective length of database: 14,082,258
effective search space: 9012645120
effective search space used: 9012645120
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.