Guide to the Human Genome
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Search of human proteins with 9910352

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|9910352 SH3-domain GRB2-like endophilin B2 [Homo sapiens]
         (395 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|9910352 SH3-domain GRB2-like endophilin B2 [Homo sapiens]          780   0.0  
gi|7705773 SH3-containing protein SH3GLB1 [Homo sapiens]              466   e-131
gi|4506929 SH3-domain GRB2-like 1 [Homo sapiens]                      101   1e-21
gi|4506931 SH3-domain GRB2-like 2 [Homo sapiens]                       97   3e-20
gi|223468657 SH3-domain GRB2-like 3 [Homo sapiens]                     90   4e-18
gi|50843948 Rho GTPase activating protein 10 [Homo sapiens]            50   4e-06
gi|151108509 Rho GTPase-activating protein RICH2 [Homo sapiens]        49   1e-05
gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 ...    48   1e-05
gi|208022687 GTPase regulator associated with the focal adhesion...    48   2e-05
gi|20149528 proline-serine-threonine phosphatase interacting pro...    47   2e-05
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]         47   4e-05
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]         47   4e-05
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]         47   4e-05
gi|4507249 signal transducing adaptor molecule 1 [Homo sapiens]        45   9e-05
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H...    45   1e-04
gi|242117948 SH3 domain-containing protein C1orf113 isoform 2 [H...    45   1e-04
gi|157412249 RUN and SH3 domain containing 1 isoform c [Homo sap...    42   7e-04
gi|157412247 RUN and SH3 domain containing 1 isoform b [Homo sap...    42   7e-04
gi|157412245 RUN and SH3 domain containing 1 isoform a [Homo sap...    42   7e-04
gi|42476123 RUN and SH3 domain containing 1 isoform d [Homo sapi...    42   7e-04
gi|85815829 SH3-domain binding protein 1 [Homo sapiens]                42   7e-04
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]                42   0.001
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]                42   0.001
gi|5453710 LIM and SH3 protein 1 [Homo sapiens]                        41   0.002
gi|145309326 laminin, gamma 1 precursor [Homo sapiens]                 41   0.002
gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens]               41   0.002
gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [...    41   0.002
gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ...    41   0.002
gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ...    41   0.002
gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ...    41   0.002

>gi|9910352 SH3-domain GRB2-like endophilin B2 [Homo sapiens]
          Length = 395

 Score =  780 bits (2013), Expect = 0.0
 Identities = 395/395 (100%), Positives = 395/395 (100%)

Query: 1   MDFNMKKLASDAGIFFTRAVQFTEEKFGQAEKTELDAHFENLLARADSTKNWTEKILRQT 60
           MDFNMKKLASDAGIFFTRAVQFTEEKFGQAEKTELDAHFENLLARADSTKNWTEKILRQT
Sbjct: 1   MDFNMKKLASDAGIFFTRAVQFTEEKFGQAEKTELDAHFENLLARADSTKNWTEKILRQT 60

Query: 61  EVLLQPNPSARVEEFLYEKLDRKVPSRVTNGELLAQYMADAASELGPTTPYGKTLIKVAE 120
           EVLLQPNPSARVEEFLYEKLDRKVPSRVTNGELLAQYMADAASELGPTTPYGKTLIKVAE
Sbjct: 61  EVLLQPNPSARVEEFLYEKLDRKVPSRVTNGELLAQYMADAASELGPTTPYGKTLIKVAE 120

Query: 121 AEKQLGAAERDFIHTASISFLTPLRNFLEGDWKTISKERRLLQNRRLDLDACKARLKKAK 180
           AEKQLGAAERDFIHTASISFLTPLRNFLEGDWKTISKERRLLQNRRLDLDACKARLKKAK
Sbjct: 121 AEKQLGAAERDFIHTASISFLTPLRNFLEGDWKTISKERRLLQNRRLDLDACKARLKKAK 180

Query: 181 AAEAKATTVPDFQETRPRNYILSASASALWNDEVDKAEQELRVAQTEFDRQAEVTRLLLE 240
           AAEAKATTVPDFQETRPRNYILSASASALWNDEVDKAEQELRVAQTEFDRQAEVTRLLLE
Sbjct: 181 AAEAKATTVPDFQETRPRNYILSASASALWNDEVDKAEQELRVAQTEFDRQAEVTRLLLE 240

Query: 241 GISSTHVNHLRCLHEFVKSQTTYYAQCYRHMLDLQKQLGRFPGTFVGTTEPASPPLSSTS 300
           GISSTHVNHLRCLHEFVKSQTTYYAQCYRHMLDLQKQLGRFPGTFVGTTEPASPPLSSTS
Sbjct: 241 GISSTHVNHLRCLHEFVKSQTTYYAQCYRHMLDLQKQLGRFPGTFVGTTEPASPPLSSTS 300

Query: 301 PTTAAATMPVVPSVASLAPPGEASLCLEEVAPPASGTRKARVLYDYEAADSSELALLADE 360
           PTTAAATMPVVPSVASLAPPGEASLCLEEVAPPASGTRKARVLYDYEAADSSELALLADE
Sbjct: 301 PTTAAATMPVVPSVASLAPPGEASLCLEEVAPPASGTRKARVLYDYEAADSSELALLADE 360

Query: 361 LITVYSLPGMDPDWLIGERGNKKGKVPVTYLELLS 395
           LITVYSLPGMDPDWLIGERGNKKGKVPVTYLELLS
Sbjct: 361 LITVYSLPGMDPDWLIGERGNKKGKVPVTYLELLS 395


>gi|7705773 SH3-containing protein SH3GLB1 [Homo sapiens]
          Length = 365

 Score =  466 bits (1198), Expect = e-131
 Identities = 237/396 (59%), Positives = 295/396 (74%), Gaps = 35/396 (8%)

Query: 1   MDFNMKKLASDAGIFFTRAVQFTEEKFGQAEKTELDAHFENLLARADSTKNWTEKILRQT 60
           MDFN+KKLA+DAG F +RAVQFTEEK GQAEKTELDAH ENLL++A+ TK WTEKI++QT
Sbjct: 4   MDFNVKKLAADAGTFLSRAVQFTEEKLGQAEKTELDAHLENLLSKAECTKIWTEKIMKQT 63

Query: 61  EVLLQPNPSARVEEFLYEKLDRKVPSRVTNGELLAQYMADAASELGPTTPYGKTLIKVAE 120
           EVLLQPNP+AR+EEF+YEKLDRK PSR+ N ELL QYM DA +E GP T YG  LIK  E
Sbjct: 64  EVLLQPNPNARIEEFVYEKLDRKAPSRINNPELLGQYMIDAGTEFGPGTAYGNALIKCGE 123

Query: 121 AEKQLGAAERDFIHTASISFLTPLRNFLEGDWKTISKERRLLQNRRLDLDACKARLKKAK 180
            +K++G A+R+ I T++++FLTPLRNF+EGD+KTI+KER+LLQN+RLDLDA K RLKKAK
Sbjct: 124 TQKRIGTADRELIQTSALNFLTPLRNFIEGDYKTIAKERKLLQNKRLDLDAAKTRLKKAK 183

Query: 181 AAEAKATTVPDFQETRPRNYILSASASALWNDEVDKAEQELRVAQTEFDRQAEVTRLLLE 240
           AAE +                             + +EQELR+ Q+EFDRQAE+TRLLLE
Sbjct: 184 AAETR-----------------------------NSSEQELRITQSEFDRQAEITRLLLE 214

Query: 241 GISSTHVNHLRCLHEFVKSQTTYYAQCYRHMLDLQKQLGRFPGTFVGTTEPAS-PPLSST 299
           GISSTH +HLRCL++FV++Q TYYAQCY++MLDLQKQLG FP  ++      S  P+ S 
Sbjct: 215 GISSTHAHHLRCLNDFVEAQMTYYAQCYQYMLDLQKQLGSFPSNYLSNNNQTSVTPVPSV 274

Query: 300 SPTTAAATMPVVPSVASLAPPGEASLCLEEVAPPASGTRKARVLYDYEAADSSELALLAD 359
            P    ++     S   +  P   S   E      SG+RKARVLYDY+AA+S+EL+LLAD
Sbjct: 275 LPNAIGSSAMASTSGLVITSPSNLSDLKE-----CSGSRKARVLYDYDAANSTELSLLAD 329

Query: 360 ELITVYSLPGMDPDWLIGERGNKKGKVPVTYLELLS 395
           E+ITV+S+ GMD DWL+GERGN+KGKVP+TYLELL+
Sbjct: 330 EVITVFSVVGMDSDWLMGERGNQKGKVPITYLELLN 365


>gi|4506929 SH3-domain GRB2-like 1 [Homo sapiens]
          Length = 368

 Score =  101 bits (251), Expect = 1e-21
 Identities = 95/400 (23%), Positives = 156/400 (39%), Gaps = 67/400 (16%)

Query: 16  FTRAVQFTEEKFGQAEKTELDAHFENLLARADSTKNWTEKILRQTEVLLQPNPSARVEEF 75
           F +A Q   EK G AE T+LD  F+ +  + D T     ++L +T   LQPNP++R +  
Sbjct: 10  FYKASQLVSEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQPNPASRAKLT 69

Query: 76  LYEKLDR-----KVPSRVTNGELLAQYMADAASELGPTTPYGKTLIKVAEAEKQLGAAER 130
           +   + +     K P    +  LL + M     ELG  + +G  L+   E+ K+L   + 
Sbjct: 70  MLNTVSKIRGQVKNPGYPQSEGLLGECMIRHGKELGGESNFGDALLDAGESMKRLAEVKD 129

Query: 131 DFIHTASISFLTPLRNFLEGDWKTISKERRLLQNRRLDLDACKARLKKAKAAEAKATTVP 190
                   +F+ PL+N  E D K I    + L+ RRLD D  K R  K          +P
Sbjct: 130 SLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQGK----------IP 179

Query: 191 DFQETRPRNYILSASASALWNDEVDKAEQELRVAQTEFDRQAEVTRLLLEGISSTHVNHL 250
           D                           +ELR A  +F+   EV    +  +  T +  +
Sbjct: 180 D---------------------------EELRQALEKFEESKEVAETSMHNLLETDIEQV 212

Query: 251 RCLHEFVKSQTTYYAQCYRHMLDLQKQLGRFPGTFVGTTEPASPPLSSTSPTT------- 303
             L   V +Q  Y+ Q  + + +L ++L R         E +S P     P         
Sbjct: 213 SQLSALVDAQLDYHRQAVQILDELAEKLKR------RMREASSRPKREYKPKPREPFDLG 266

Query: 304 ---------AAATMPVVPSVASLAPPGEASLCLEEVAPPASGTRKARVLYDYEAADSSEL 354
                       T P + + +S     +         PP       + LYD+E  +  EL
Sbjct: 267 EPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPSRSMPPLD-QPSCKALYDFEPENDGEL 325

Query: 355 ALLADELITVYSLPGMDPDWLIGERGNKKGKVPVTYLELL 394
                ++IT+ +   +D +W  G    + G  P++Y+E+L
Sbjct: 326 GFHEGDVITLTN--QIDENWYEGMLDGQSGFFPLSYVEVL 363


>gi|4506931 SH3-domain GRB2-like 2 [Homo sapiens]
          Length = 352

 Score = 97.1 bits (240), Expect = 3e-20
 Identities = 95/388 (24%), Positives = 153/388 (39%), Gaps = 59/388 (15%)

Query: 16  FTRAVQFTEEKFGQAEKTELDAHFENLLARADSTKNWTEKILRQTEVLLQPNPSARVEEF 75
           F +A Q   EK G AE T+LD  F+ +  + D T     +I+ +T   LQPNP++R +  
Sbjct: 10  FHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPASRAKLS 69

Query: 76  LYEKLDR-----KVPSRVTNGELLAQYMADAASELGPTTPYGKTLIKVAEAEKQLGAAER 130
           +   + +     K P       LLA+ M     ELG    +G  L +V EA ++L   + 
Sbjct: 70  MINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMRELSEVKD 129

Query: 131 DFIHTASISFLTPLRNFLEGDWKTISKERRLLQNRRLDLDACKARLKKAKAAEAKATTVP 190
                   +F+ PL+N  + D + I    + L+ RRLD D  K R  K          +P
Sbjct: 130 SLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGK----------IP 179

Query: 191 DFQETRPRNYILSASASALWNDEVDKAEQELRVAQTEFDRQAEVTRLLLEGISSTHVNHL 250
           D                           +ELR A  +FD   E+    +  +    +  +
Sbjct: 180 D---------------------------EELRQALEKFDESKEIAESSMFNLLEMDIEQV 212

Query: 251 RCLHEFVKSQTTYYAQCYRHMLDLQKQLGRFPGTFVGTTEPASPPLSSTSPTTAAATMPV 310
             L   V++Q  Y+ Q  + +  +  +L           + +S P     P    +    
Sbjct: 213 SQLSALVQAQLEYHKQAVQILQQVTVRLEE------RIRQASSQPRREYQPKPRMSL--E 264

Query: 311 VPSVASLAPPGEASLCLEEVAPPASGTRK----ARVLYDYEAADSSELALLADELITVYS 366
            P+  S  P G  S       P  SG +      R LYD+E  +  EL     ++IT+ +
Sbjct: 265 FPTGDSTQPNGGLS---HTGTPKPSGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTN 321

Query: 367 LPGMDPDWLIGERGNKKGKVPVTYLELL 394
              +D +W  G      G  P+ Y+E+L
Sbjct: 322 --QIDENWYEGMLHGHSGFFPINYVEIL 347


>gi|223468657 SH3-domain GRB2-like 3 [Homo sapiens]
          Length = 347

 Score = 89.7 bits (221), Expect = 4e-18
 Identities = 92/387 (23%), Positives = 151/387 (39%), Gaps = 62/387 (16%)

Query: 16  FTRAVQFTEEKFGQAEKTELDAHFENLLARADSTKNWTEKILRQTEVLLQPNPSARVEEF 75
           F +A Q   EK   AE T+LD  F ++  + D T     +IL +T   LQPNP+ R +  
Sbjct: 10  FHKASQLFSEKISGAEGTKLDDEFLDMERKIDVTNKVVAEILSKTTEYLQPNPAYRAKLG 69

Query: 76  LYEKLDRKVPSRVTNGE-----LLAQYMADAASELGPTTPYGKTLIKVAEAEKQLGAAER 130
           +   + +      T G      LL   M     ELG  + +G  LI+V E+ K +   + 
Sbjct: 70  MLNTVSKIRGQVKTTGYPQTEGLLGDCMLKYGKELGEDSTFGNALIEVGESMKLMAEVKD 129

Query: 131 DFIHTASISFLTPLRNFLEGDWKTISKERRLLQNRRLDLDACKARLKKAKAAEAKATTVP 190
                   +F+ PL+   + D K I    + L+ RRLD D  K R+ K          +P
Sbjct: 130 SLDINVKQTFIDPLQLLQDKDLKEIGHHLKKLEGRRLDYDYKKKRVGK----------IP 179

Query: 191 DFQETRPRNYILSASASALWNDEVDKAEQELRVAQTEFDRQAEVTRLLLEGISSTHVNHL 250
           D                           +E+R A  +F+   E+    +       V  +
Sbjct: 180 D---------------------------EEVRQAVEKFEESKELAERSMFNFLENDVEQV 212

Query: 251 RCLHEFVKSQTTYYAQCYRHMLDLQK--QLGRFPGTFVGTTEPASPPLS-STSPTTAAAT 307
             L  F+++   Y+ Q    + +LQ   Q+     + V   E    P+  S+S     +T
Sbjct: 213 SQLAVFIEAALDYHRQSTEILQELQSKLQMRISAASSVPRREYKPRPVKRSSSELNGVST 272

Query: 308 MPVVPSVASLAPPGEASLCLEEVAPPASGTRKARVLYDYEAADSSELALLADELITVYSL 367
             VV +  S  P  +                  R LYD+E  +  EL     ++IT+ + 
Sbjct: 273 TSVVKTTGSNIPMDQPC---------------CRGLYDFEPENQGELGFKEGDIITLTN- 316

Query: 368 PGMDPDWLIGERGNKKGKVPVTYLELL 394
             +D +W  G    + G  P+ Y+E++
Sbjct: 317 -QIDENWYEGMIHGESGFFPINYVEVI 342


>gi|50843948 Rho GTPase activating protein 10 [Homo sapiens]
          Length = 786

 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 38/129 (29%), Positives = 59/129 (45%), Gaps = 7/129 (5%)

Query: 270 HMLDLQKQLGRFPGTFVGTTEPASPP-LSSTSPTTAAATMPVVPSVASLAP-PGEASLCL 327
           H+L      G +  T  G T  +    L+  SPTT ++   V P     +P P      +
Sbjct: 661 HLLADGGSFGDWASTIPGQTRSSMVQWLNPQSPTTTSSNSAVTPLSPGSSPFPFSPPATV 720

Query: 328 EEVAPPASGTRKARVLYDYEAADSSELALLADELITVYS--LPGMDPDWLIGERGNKKGK 385
            +  P +  +RKAR +Y  EA  SSEL+    E+  ++       +P WL G    K+G 
Sbjct: 721 ADKPPESIRSRKARAVYPCEAEHSSELSF---EIGAIFEDVQTSREPGWLEGTLNGKRGL 777

Query: 386 VPVTYLELL 394
           +P  Y++LL
Sbjct: 778 IPQNYVKLL 786


>gi|151108509 Rho GTPase-activating protein RICH2 [Homo sapiens]
          Length = 818

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 69/341 (20%), Positives = 126/341 (36%), Gaps = 33/341 (9%)

Query: 16  FTRAVQFTEEKFGQAEKTELDAHFENLLA---RADSTKNWTEKILRQTEVLLQPNPSARV 72
           F R  Q   +  G+AEKTE+ +  E+LL    R +  K  +    ++    LQ    A  
Sbjct: 5   FNRMRQLANQTVGRAEKTEVLS--EDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGAEA 62

Query: 73  EEFLYEKLDRKVPSRVTNGELLAQYMADAASELGPTTPYGKTLIKVAEAEKQLGAAERDF 132
           +     K  +K+P        LAQ + + ++ LG  T  GK L    E E +L      F
Sbjct: 63  D-----KRSKKLPLTT-----LAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIHF 112

Query: 133 IHTASISFLTPLRNFLEGDWKTISKERRLLQNRRLDLDACKARLKKAKAAEAKATTVPDF 192
                   + PL    E +   I K+R+ L    LD+D+ + R ++   +   ++++   
Sbjct: 113 ELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQP- 171

Query: 193 QETRPRNYILSASASALWNDEVDKAEQELRVAQTEFDRQAEVTRLLLEGISSTHVNHLRC 252
                      A A AL  +E+++A   + + + +           +    +  +++   
Sbjct: 172 ---------AGAKADAL-REEMEEAANRVEICRDQLSAD-------MYSFVAKEIDYANY 214

Query: 253 LHEFVKSQTTYYAQCYRHMLDLQKQLGRFPGTFVGTTEPASPPLSSTSPTTAAATMPVVP 312
               ++ Q  Y+ +    +  +  Q+      +V       P     + +      P+  
Sbjct: 215 FQTLIEVQAEYHRKSLTLLQAVLPQIKAQQEAWVEKPSFGKPLEEHLTISGREIAFPIEA 274

Query: 313 SVASLAPPGEASLCLEEVAPPASGTRKARVLYDYEAADSSE 353
            V  L   G     L  VAP AS  +K +   D    D  E
Sbjct: 275 CVTMLLECGMQEEGLFRVAPSASKLKKLKAALDCCVVDVQE 315


>gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1
           [Homo sapiens]
          Length = 878

 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 65/262 (24%), Positives = 108/262 (41%), Gaps = 25/262 (9%)

Query: 148 LEGDWKTISKERRLLQNRRL------DLDAC----KARLKKAKAAEAKATTVPDF---QE 194
           L GD ++   E RL+Q R+        +  C    +  + +  + E   T  P F    E
Sbjct: 620 LRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSREIDYTAYPWFAGNME 679

Query: 195 TRPRNYILSASASALWNDEVDKAEQELRVAQTEFDRQAEVTRLLLEG--ISSTHVNHLRC 252
            +  + +L + AS  +      AE E      +F+ + +  +++ +   I  T       
Sbjct: 680 RQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDNWIHITEAKKFDS 739

Query: 253 LHEFVKSQTTYYAQCYRHMLDLQKQLGRFPGTFVGTTEPASPPLSSTSPTTAAAT--MPV 310
           L E V+     Y QC+  + +  KQL         + E ++   SS SP + A+     +
Sbjct: 740 LLELVE-----YYQCHS-LKESFKQLDTTLKYPYKSRERSASRASSRSPASCASYNFSFL 793

Query: 311 VPSVASLAPPGEASLCLEEVAPPASGTRKARVLYDYEAADSSELALLADELITVYSLPGM 370
            P   S A  G ++       P   GT  AR  Y++ A D  EL+L   +++ +YS  G 
Sbjct: 794 SPQGLSFASQGPSAPFWSVFTPRVIGTAVAR--YNFAARDMRELSLREGDVVRIYSRIGG 851

Query: 371 DPDWLIGERGNKKGKVPVTYLE 392
           D  W  GE   + G  P TY+E
Sbjct: 852 DQGWWKGETNGRIGWFPSTYVE 873


>gi|208022687 GTPase regulator associated with the focal adhesion
           kinase pp125 isoform b [Homo sapiens]
          Length = 759

 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 31/111 (27%), Positives = 50/111 (45%), Gaps = 5/111 (4%)

Query: 286 VGTTEPASPPLSSTSPTTAAATMPVVPSVASLAPPGEASLCLEEVAPPASGTRKARVLYD 345
           +   +P  P     +P+  +   P  P  ++ + P   S    + +P ++  RKA+ LY 
Sbjct: 652 LAVVKPTRPNSLPPNPSPTSPLSPSWPMFSAPSSPMPTSSTSSDSSPVSTPFRKAKALYA 711

Query: 346 YEAADSSELALLADELITVYS--LPGMDPDWLIGERGNKKGKVPVTYLELL 394
            +A   SEL+  A    TV+    P  +P WL G    K G +P  Y+E L
Sbjct: 712 CKAEHDSELSFTAG---TVFDNVHPSQEPGWLEGTLNGKTGLIPENYVEFL 759


>gi|20149528 proline-serine-threonine phosphatase interacting
           protein 1 [Homo sapiens]
          Length = 416

 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 38/115 (33%), Positives = 56/115 (48%), Gaps = 8/115 (6%)

Query: 280 RFPGTFVGTTEPASPPLSSTSPTTAAATMPVVPSVASLAPPGEASLCLEEVAPPASGTRK 339
           RF G   G+      P +++   +AA+T  + P+         A    E    PAS  ++
Sbjct: 310 RFSGLLHGS------PKTTSLAASAASTETLTPTPERNEGVYTAIAVQEIQGNPASPAQE 363

Query: 340 ARVLYDYEAADSSELALLADELITVYSLPGMDPDWLIGERGNKKGKVPVTYLELL 394
            R LYDY A +  EL L A +++ V  L G D  W + ER  ++G VP +YLE L
Sbjct: 364 YRALYDYTAQNPDELDLSAGDILEVI-LEGEDGWWTV-ERNGQRGFVPGSYLEKL 416


>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
          Length = 731

 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 29/85 (34%), Positives = 42/85 (49%), Gaps = 6/85 (7%)

Query: 310 VVPSVASLAPPGEASLCLEEVAPPASGTRKARVLYDYEAADSSELALLADELITVYSLPG 369
           + P+V     P EA   L  + P     RKA+ LYD+   +  EL+  A ++IT   L  
Sbjct: 650 IFPAVFVRPCPAEAKSMLA-IVPKG---RKAKALYDFRGENEDELSFKAGDIIT--ELES 703

Query: 370 MDPDWLIGERGNKKGKVPVTYLELL 394
           +D DW+ GE   K G  P  Y++ L
Sbjct: 704 VDDDWMSGELMGKSGIFPKNYIQFL 728


>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
          Length = 767

 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 29/85 (34%), Positives = 42/85 (49%), Gaps = 6/85 (7%)

Query: 310 VVPSVASLAPPGEASLCLEEVAPPASGTRKARVLYDYEAADSSELALLADELITVYSLPG 369
           + P+V     P EA   L  + P     RKA+ LYD+   +  EL+  A ++IT   L  
Sbjct: 686 IFPAVFVRPCPAEAKSMLA-IVPKG---RKAKALYDFRGENEDELSFKAGDIIT--ELES 739

Query: 370 MDPDWLIGERGNKKGKVPVTYLELL 394
           +D DW+ GE   K G  P  Y++ L
Sbjct: 740 VDDDWMSGELMGKSGIFPKNYIQFL 764


>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
          Length = 790

 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 29/85 (34%), Positives = 42/85 (49%), Gaps = 6/85 (7%)

Query: 310 VVPSVASLAPPGEASLCLEEVAPPASGTRKARVLYDYEAADSSELALLADELITVYSLPG 369
           + P+V     P EA   L  + P     RKA+ LYD+   +  EL+  A ++IT   L  
Sbjct: 709 IFPAVFVRPCPAEAKSMLA-IVPKG---RKAKALYDFRGENEDELSFKAGDIIT--ELES 762

Query: 370 MDPDWLIGERGNKKGKVPVTYLELL 394
           +D DW+ GE   K G  P  Y++ L
Sbjct: 763 VDDDWMSGELMGKSGIFPKNYIQFL 787


>gi|4507249 signal transducing adaptor molecule 1 [Homo sapiens]
          Length = 540

 Score = 45.4 bits (106), Expect = 9e-05
 Identities = 41/133 (30%), Positives = 56/133 (42%), Gaps = 16/133 (12%)

Query: 273 DLQKQLGRFP--GTFVGTTEPASPPLSSTSPTTAAATMPVVPSVA----SLAPPGEASLC 326
           +L++Q   FP  G+       ASP L +  P T A              SL    + S  
Sbjct: 134 NLKEQGVTFPAIGSQAAEQAKASPALVAKDPGTVANKKEEEDLAKAIELSLKEQRQQSTT 193

Query: 327 LEEVAPPASGT--------RKARVLYDYEAADSSELALLADELITVYSLPGMDPDWLIGE 378
           L  + P  S          RK R +YD+EAA+ +EL   A E+ITV  L   DP+W  GE
Sbjct: 194 LSTLYPSTSSLLTNHQHEGRKVRAIYDFEAAEDNELTFKAGEIITV--LDDSDPNWWKGE 251

Query: 379 RGNKKGKVPVTYL 391
                G  P  ++
Sbjct: 252 THQGIGLFPSNFV 264


>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
           sapiens]
          Length = 756

 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 35/118 (29%), Positives = 52/118 (44%), Gaps = 11/118 (9%)

Query: 277 QLGRFPGTFVGTTEPASPPLSSTSPTTAAATMPVVPSVASLA---PPGEASLCLEEVAPP 333
           QLG FP  FV   +   P L +    + +      P ++SLA   PP      L+ V+ P
Sbjct: 128 QLGAFPSNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDY----LQTVSHP 183

Query: 334 ASGTRKARVLYDYEAADSSELALLADELITVYSLPGMDPDWLIGERGNKKGKVPVTYL 391
                  RVL+DY+     ELAL   +++ V S    D  W  GE   ++G  P  ++
Sbjct: 184 ----EVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFV 237



 Score = 31.6 bits (70), Expect = 1.3
 Identities = 19/72 (26%), Positives = 33/72 (45%), Gaps = 5/72 (6%)

Query: 326 CLEEVAPPASGTRKAR---VLYDYEAADSSELALLADELITVYSLPGMDPDWLIGERGNK 382
           C      PA   R  R   V + Y    + EL L A E++ +  +  ++  W +G++  +
Sbjct: 71  CARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEM--IKEIEDGWWLGKKNGQ 128

Query: 383 KGKVPVTYLELL 394
            G  P  ++ELL
Sbjct: 129 LGAFPSNFVELL 140


>gi|242117948 SH3 domain-containing protein C1orf113 isoform 2 [Homo
           sapiens]
          Length = 645

 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 35/118 (29%), Positives = 52/118 (44%), Gaps = 11/118 (9%)

Query: 277 QLGRFPGTFVGTTEPASPPLSSTSPTTAAATMPVVPSVASLA---PPGEASLCLEEVAPP 333
           QLG FP  FV   +   P L +    + +      P ++SLA   PP      L+ V+ P
Sbjct: 17  QLGAFPSNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDY----LQTVSHP 72

Query: 334 ASGTRKARVLYDYEAADSSELALLADELITVYSLPGMDPDWLIGERGNKKGKVPVTYL 391
                  RVL+DY+     ELAL   +++ V S    D  W  GE   ++G  P  ++
Sbjct: 73  ----EVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFV 126


>gi|157412249 RUN and SH3 domain containing 1 isoform c [Homo
           sapiens]
          Length = 492

 Score = 42.4 bits (98), Expect = 7e-04
 Identities = 41/120 (34%), Positives = 56/120 (46%), Gaps = 5/120 (4%)

Query: 278 LGRFPGTFVGTTEPASPPLSSTSPTT-AAATMPVVPSVASLAPPGEASLC-LEEVAPPAS 335
           LGR  G   G  E  +  L S  P++    T+ V+  V   APP   S   LE  AP   
Sbjct: 374 LGRLFGVPGGPAENENGALKSRRPSSWLPPTVSVLALVKRGAPPEMPSPQELEASAPRMV 433

Query: 336 GTRKA-RVLYDYEAADSSELALLADELITVYSLPGMDPDWLIGERGNKKGKVPVTYLELL 394
            T +A R L D+ AA   +L+    E++ V +   +D DWL   R   +G VPV Y  L+
Sbjct: 434 QTHRAVRALCDHTAARPDQLSFRRGEVLRVITT--VDEDWLRCGRDGMEGLVPVGYTSLV 491


>gi|157412247 RUN and SH3 domain containing 1 isoform b [Homo
           sapiens]
          Length = 796

 Score = 42.4 bits (98), Expect = 7e-04
 Identities = 41/120 (34%), Positives = 56/120 (46%), Gaps = 5/120 (4%)

Query: 278 LGRFPGTFVGTTEPASPPLSSTSPTT-AAATMPVVPSVASLAPPGEASLC-LEEVAPPAS 335
           LGR  G   G  E  +  L S  P++    T+ V+  V   APP   S   LE  AP   
Sbjct: 678 LGRLFGVPGGPAENENGALKSRRPSSWLPPTVSVLALVKRGAPPEMPSPQELEASAPRMV 737

Query: 336 GTRKA-RVLYDYEAADSSELALLADELITVYSLPGMDPDWLIGERGNKKGKVPVTYLELL 394
            T +A R L D+ AA   +L+    E++ V +   +D DWL   R   +G VPV Y  L+
Sbjct: 738 QTHRAVRALCDHTAARPDQLSFRRGEVLRVITT--VDEDWLRCGRDGMEGLVPVGYTSLV 795


>gi|157412245 RUN and SH3 domain containing 1 isoform a [Homo
           sapiens]
          Length = 902

 Score = 42.4 bits (98), Expect = 7e-04
 Identities = 41/120 (34%), Positives = 56/120 (46%), Gaps = 5/120 (4%)

Query: 278 LGRFPGTFVGTTEPASPPLSSTSPTT-AAATMPVVPSVASLAPPGEASLC-LEEVAPPAS 335
           LGR  G   G  E  +  L S  P++    T+ V+  V   APP   S   LE  AP   
Sbjct: 784 LGRLFGVPGGPAENENGALKSRRPSSWLPPTVSVLALVKRGAPPEMPSPQELEASAPRMV 843

Query: 336 GTRKA-RVLYDYEAADSSELALLADELITVYSLPGMDPDWLIGERGNKKGKVPVTYLELL 394
            T +A R L D+ AA   +L+    E++ V +   +D DWL   R   +G VPV Y  L+
Sbjct: 844 QTHRAVRALCDHTAARPDQLSFRRGEVLRVITT--VDEDWLRCGRDGMEGLVPVGYTSLV 901


>gi|42476123 RUN and SH3 domain containing 1 isoform d [Homo
           sapiens]
          Length = 433

 Score = 42.4 bits (98), Expect = 7e-04
 Identities = 41/120 (34%), Positives = 56/120 (46%), Gaps = 5/120 (4%)

Query: 278 LGRFPGTFVGTTEPASPPLSSTSPTT-AAATMPVVPSVASLAPPGEASLC-LEEVAPPAS 335
           LGR  G   G  E  +  L S  P++    T+ V+  V   APP   S   LE  AP   
Sbjct: 315 LGRLFGVPGGPAENENGALKSRRPSSWLPPTVSVLALVKRGAPPEMPSPQELEASAPRMV 374

Query: 336 GTRKA-RVLYDYEAADSSELALLADELITVYSLPGMDPDWLIGERGNKKGKVPVTYLELL 394
            T +A R L D+ AA   +L+    E++ V +   +D DWL   R   +G VPV Y  L+
Sbjct: 375 QTHRAVRALCDHTAARPDQLSFRRGEVLRVITT--VDEDWLRCGRDGMEGLVPVGYTSLV 432


>gi|85815829 SH3-domain binding protein 1 [Homo sapiens]
          Length = 701

 Score = 42.4 bits (98), Expect = 7e-04
 Identities = 40/145 (27%), Positives = 59/145 (40%), Gaps = 8/145 (5%)

Query: 43  LARADSTKNWTEKILRQTEVLLQP------NPSARVEEFLYEKLDRKVPSRVTNGELLA- 95
           L R   T  +  + L Q E  L+P      N   R++  L  +    +  RV    L+A 
Sbjct: 18  LGRTPETAEFLGEDLLQVEQRLEPAKRAAHNIHKRLQACLQGQSGADMDKRVKKLPLMAL 77

Query: 96  -QYMADAASELGPTTPYGKTLIKVAEAEKQLGAAERDFIHTASISFLTPLRNFLEGDWKT 154
              MA++  EL P +  GK L      + QL     +F  T     L PL    E +   
Sbjct: 78  STTMAESFKELDPDSSMGKALEMSCAIQNQLARILAEFEMTLERDVLQPLSRLSEEELPA 137

Query: 155 ISKERRLLQNRRLDLDACKARLKKA 179
           I K ++ LQ    D +  K+RL +A
Sbjct: 138 ILKHKKSLQKLVSDWNTLKSRLSQA 162


>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
          Length = 1220

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 30/119 (25%), Positives = 46/119 (38%), Gaps = 29/119 (24%)

Query: 275  QKQLGRFPGTFVGTTEPASPPLSSTSPTTAAATMPVVPSVASLAPPGEASLCLEEVAPPA 334
            ++Q+G FP  +V    P +  ++ T P  + A   V   +                    
Sbjct: 1122 KRQIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIG------------------- 1162

Query: 335  SGTRKARVLYDYEAADSSELALLADELITVYSLPGMDPDWLIGERGNKKGKVPVTYLEL 393
                    +YDY A +  ELA    ++I V  L   DPDW  GE   + G  P  Y++L
Sbjct: 1163 --------MYDYTAQNDDELAFNKGQIINV--LNKEDPDWWKGEVNGQVGLFPSNYVKL 1211



 Score = 38.5 bits (88), Expect = 0.011
 Identities = 32/121 (26%), Positives = 52/121 (42%), Gaps = 16/121 (13%)

Query: 273  DLQKQLGRFPGTFVGTTEPASPPLSSTSPTTAAATMPVVPSVASLAPPGEASLCLEEVAP 332
            ++Q Q G FP ++V     + P   STS  + ++  P   S+  +A P          A 
Sbjct: 953  EVQGQKGWFPKSYVKLI--SGPIRKSTSMDSGSSESPA--SLKRVASPA---------AK 999

Query: 333  PASGTRKARVLYDYEAADSSELALLADELITVYSLPGMDPDWLIGERGNKKGKVPVTYLE 392
            P     +   +Y YE+++  +L     ++I V    G   DW  G  G+K G  P  Y+ 
Sbjct: 1000 PVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKKDG---DWWTGTVGDKAGVFPSNYVR 1056

Query: 393  L 393
            L
Sbjct: 1057 L 1057



 Score = 32.0 bits (71), Expect = 1.00
 Identities = 34/136 (25%), Positives = 53/136 (38%), Gaps = 29/136 (21%)

Query: 286 VGTTEPASPP-----LSSTSPTTA-----AATMPVVPSVASLAPPGEASLCLEEVAPPAS 335
           V ++EP++ P      SST PT+              +  SL  P    L       PA+
Sbjct: 838 VTSSEPSTTPNNWADFSSTWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPAT 897

Query: 336 GTR----------------KARVLYDYEAADSSELALLADELITVYSLPGMDPDWLIGER 379
            T                 +A+ LY + A   + L    +++ITV     M   W  GE 
Sbjct: 898 ATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDM---WWFGEV 954

Query: 380 GNKKGKVPVTYLELLS 395
             +KG  P +Y++L+S
Sbjct: 955 QGQKGWFPKSYVKLIS 970



 Score = 28.9 bits (63), Expect = 8.5
 Identities = 18/58 (31%), Positives = 26/58 (44%), Gaps = 7/58 (12%)

Query: 341 RVLYDYEAADSSELALLADELITVY------SLPGMDPDWLIGERGNKKGKVPVTYLE 392
           R LY +E+    E+ +   +++ V       S  G +P WL GE   K G  P  Y E
Sbjct: 746 RALYPFESRSHDEITIQPGDIVMVKGEWVDESQTG-EPGWLGGELKGKTGWFPANYAE 802


>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
          Length = 1721

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 30/119 (25%), Positives = 46/119 (38%), Gaps = 29/119 (24%)

Query: 275  QKQLGRFPGTFVGTTEPASPPLSSTSPTTAAATMPVVPSVASLAPPGEASLCLEEVAPPA 334
            ++Q+G FP  +V    P +  ++ T P  + A   V   +                    
Sbjct: 1122 KRQIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIG------------------- 1162

Query: 335  SGTRKARVLYDYEAADSSELALLADELITVYSLPGMDPDWLIGERGNKKGKVPVTYLEL 393
                    +YDY A +  ELA    ++I V  L   DPDW  GE   + G  P  Y++L
Sbjct: 1163 --------MYDYTAQNDDELAFNKGQIINV--LNKEDPDWWKGEVNGQVGLFPSNYVKL 1211



 Score = 38.5 bits (88), Expect = 0.011
 Identities = 32/121 (26%), Positives = 52/121 (42%), Gaps = 16/121 (13%)

Query: 273  DLQKQLGRFPGTFVGTTEPASPPLSSTSPTTAAATMPVVPSVASLAPPGEASLCLEEVAP 332
            ++Q Q G FP ++V     + P   STS  + ++  P   S+  +A P          A 
Sbjct: 953  EVQGQKGWFPKSYVKLI--SGPIRKSTSMDSGSSESPA--SLKRVASPA---------AK 999

Query: 333  PASGTRKARVLYDYEAADSSELALLADELITVYSLPGMDPDWLIGERGNKKGKVPVTYLE 392
            P     +   +Y YE+++  +L     ++I V    G   DW  G  G+K G  P  Y+ 
Sbjct: 1000 PVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKKDG---DWWTGTVGDKAGVFPSNYVR 1056

Query: 393  L 393
            L
Sbjct: 1057 L 1057



 Score = 32.0 bits (71), Expect = 1.00
 Identities = 34/136 (25%), Positives = 53/136 (38%), Gaps = 29/136 (21%)

Query: 286 VGTTEPASPP-----LSSTSPTTA-----AATMPVVPSVASLAPPGEASLCLEEVAPPAS 335
           V ++EP++ P      SST PT+              +  SL  P    L       PA+
Sbjct: 838 VTSSEPSTTPNNWADFSSTWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPAT 897

Query: 336 GTR----------------KARVLYDYEAADSSELALLADELITVYSLPGMDPDWLIGER 379
            T                 +A+ LY + A   + L    +++ITV     M   W  GE 
Sbjct: 898 ATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDM---WWFGEV 954

Query: 380 GNKKGKVPVTYLELLS 395
             +KG  P +Y++L+S
Sbjct: 955 QGQKGWFPKSYVKLIS 970



 Score = 28.9 bits (63), Expect = 8.5
 Identities = 18/58 (31%), Positives = 26/58 (44%), Gaps = 7/58 (12%)

Query: 341 RVLYDYEAADSSELALLADELITVY------SLPGMDPDWLIGERGNKKGKVPVTYLE 392
           R LY +E+    E+ +   +++ V       S  G +P WL GE   K G  P  Y E
Sbjct: 746 RALYPFESRSHDEITIQPGDIVMVKGEWVDESQTG-EPGWLGGELKGKTGWFPANYAE 802


>gi|5453710 LIM and SH3 protein 1 [Homo sapiens]
          Length = 261

 Score = 41.2 bits (95), Expect = 0.002
 Identities = 27/88 (30%), Positives = 42/88 (47%), Gaps = 6/88 (6%)

Query: 309 PVVPSVASLAPPGEASLCLEEVAPPASGTRKARVLYDYEAADSSELALLADELITVYSLP 368
           PV  S      P  A + ++  AP   G R  R +YDY AAD  E++    +  T+ ++ 
Sbjct: 178 PVAQSYGGYKEPA-APVSIQRSAPGGGGKRY-RAVYDYSAADEDEVSFQDGD--TIVNVQ 233

Query: 369 GMDPDWLIG--ERGNKKGKVPVTYLELL 394
            +D  W+ G  ER    G +P  Y+E +
Sbjct: 234 QIDDGWMYGTVERTGDTGMLPANYVEAI 261


>gi|145309326 laminin, gamma 1 precursor [Homo sapiens]
          Length = 1609

 Score = 41.2 bits (95), Expect = 0.002
 Identities = 36/147 (24%), Positives = 59/147 (40%), Gaps = 6/147 (4%)

Query: 135  TASISFLTPLRNFLEGDWKTISKERRLLQNRRLDLDACKARLKKAKAAEAKATTVPDFQE 194
            ++ IS L  +RN +E       + R  ++N    ++     L+KAK A A  +       
Sbjct: 1111 SSQISRLQNIRNTIEETGNLAEQARAHVENTERLIEIASRELEKAKVAAANVSVTQPEST 1170

Query: 195  TRPRNY-ILSASASALWNDEVDKAEQELRVAQTEFDRQAEVTRLLLEGISSTHVNHLRCL 253
              P N  +L+  A  L      +A+  +RVA+T  D   E   LLL  ++  +       
Sbjct: 1171 GDPNNMTLLAEEARKLAERHKQEADDIVRVAKTANDTSTEAYNLLLRTLAGENQTAFE-- 1228

Query: 254  HEFVKSQTTYYAQCYRHMLDLQKQLGR 280
               ++     Y Q      DL+KQ  R
Sbjct: 1229 ---IEELNRKYEQAKNISQDLEKQAAR 1252


>gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens]
          Length = 330

 Score = 41.2 bits (95), Expect = 0.002
 Identities = 22/58 (37%), Positives = 29/58 (50%), Gaps = 2/58 (3%)

Query: 334 ASGTRKARVLYDYEAADSSELALLADELITVYSLPGMDPDWLIGERGNKKGKVPVTYL 391
           A   R AR LYD+EA +  EL   + E++ V  L   +P W  G   NK G  P  Y+
Sbjct: 270 AGRVRWARALYDFEALEDDELGFHSGEVVEV--LDSSNPSWWTGRLHNKLGLFPANYV 325


>gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2
           [Homo sapiens]
          Length = 839

 Score = 41.2 bits (95), Expect = 0.002
 Identities = 23/61 (37%), Positives = 32/61 (52%), Gaps = 2/61 (3%)

Query: 332 PPASGTRKARVLYDYEAADSSELALLADELITVYSLPGMDPDWLIGERGNKKGKVPVTYL 391
           P   GT  AR  Y++ A D  EL+L   +++ +YS  G D  W  GE   + G  P TY+
Sbjct: 776 PRVIGTAVAR--YNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYV 833

Query: 392 E 392
           E
Sbjct: 834 E 834


>gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo
           sapiens]
          Length = 492

 Score = 40.8 bits (94), Expect = 0.002
 Identities = 34/120 (28%), Positives = 53/120 (44%), Gaps = 15/120 (12%)

Query: 289 TEPASPPLSSTSPTTAAATMPVVPSVASLAPPGEA----SLCLEEVAPPASGTRK----- 339
           T P    L  +S T   +     PS  S A   E+    S  L ++   A   R+     
Sbjct: 196 TSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEK 255

Query: 340 ----ARVLYDYEAADSSELALLADELITVYSLPGMDPDWLIGERGNKKGKVPVTYLELLS 395
               A+ +YD++A  S EL+    +  TVY L  +D +W  GE   + G  P++Y+E L+
Sbjct: 256 EKLPAKAVYDFKAQTSKELSFKKGD--TVYILRKIDQNWYEGEHHGRVGIFPISYVEKLT 313


>gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
           sapiens]
          Length = 824

 Score = 40.8 bits (94), Expect = 0.002
 Identities = 34/120 (28%), Positives = 53/120 (44%), Gaps = 15/120 (12%)

Query: 289 TEPASPPLSSTSPTTAAATMPVVPSVASLAPPGEA----SLCLEEVAPPASGTRK----- 339
           T P    L  +S T   +     PS  S A   E+    S  L ++   A   R+     
Sbjct: 528 TSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEK 587

Query: 340 ----ARVLYDYEAADSSELALLADELITVYSLPGMDPDWLIGERGNKKGKVPVTYLELLS 395
               A+ +YD++A  S EL+    +  TVY L  +D +W  GE   + G  P++Y+E L+
Sbjct: 588 EKLPAKAVYDFKAQTSKELSFKKGD--TVYILRKIDQNWYEGEHHGRVGIFPISYVEKLT 645


>gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo
           sapiens]
          Length = 661

 Score = 40.8 bits (94), Expect = 0.002
 Identities = 34/120 (28%), Positives = 53/120 (44%), Gaps = 15/120 (12%)

Query: 289 TEPASPPLSSTSPTTAAATMPVVPSVASLAPPGEA----SLCLEEVAPPASGTRK----- 339
           T P    L  +S T   +     PS  S A   E+    S  L ++   A   R+     
Sbjct: 365 TSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEK 424

Query: 340 ----ARVLYDYEAADSSELALLADELITVYSLPGMDPDWLIGERGNKKGKVPVTYLELLS 395
               A+ +YD++A  S EL+    +  TVY L  +D +W  GE   + G  P++Y+E L+
Sbjct: 425 EKLPAKAVYDFKAQTSKELSFKKGD--TVYILRKIDQNWYEGEHHGRVGIFPISYVEKLT 482


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.130    0.369 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,637,773
Number of Sequences: 37866
Number of extensions: 642859
Number of successful extensions: 4151
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 52
Number of HSP's successfully gapped in prelim test: 149
Number of HSP's that attempted gapping in prelim test: 3807
Number of HSP's gapped (non-prelim): 478
length of query: 395
length of database: 18,247,518
effective HSP length: 104
effective length of query: 291
effective length of database: 14,309,454
effective search space: 4164051114
effective search space used: 4164051114
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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