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Search of human proteins with 94721321
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|94721321 coiled-coil domain containing 11 [Homo sapiens]
(514 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|94721321 coiled-coil domain containing 11 [Homo sapiens] 1001 0.0
gi|148746195 trichohyalin [Homo sapiens] 131 2e-30
gi|219803769 trichoplein [Homo sapiens] 129 5e-30
gi|14150056 trichoplein [Homo sapiens] 129 5e-30
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 107 3e-23
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 105 1e-22
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 104 2e-22
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 103 4e-22
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 97 4e-20
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 96 6e-20
gi|8922950 meiosis-specific nuclear structural 1 [Homo sapiens] 94 2e-19
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 91 2e-18
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 91 3e-18
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 91 3e-18
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 91 3e-18
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 91 3e-18
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 91 3e-18
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 91 3e-18
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 91 3e-18
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 91 3e-18
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 91 3e-18
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 91 3e-18
gi|217272804 hyaluronan-mediated motility receptor isoform d [Ho... 89 1e-17
gi|217272802 hyaluronan-mediated motility receptor isoform a [Ho... 89 1e-17
gi|217416398 hyaluronan-mediated motility receptor isoform c [Ho... 89 1e-17
gi|217416394 hyaluronan-mediated motility receptor isoform b [Ho... 89 1e-17
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 88 2e-17
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 87 3e-17
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 87 3e-17
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 87 4e-17
>gi|94721321 coiled-coil domain containing 11 [Homo sapiens]
Length = 514
Score = 1001 bits (2587), Expect = 0.0
Identities = 514/514 (100%), Positives = 514/514 (100%)
Query: 1 MYSQRFGTVQREVKGPTPKVVIVRSKPPKGQGAEHHLERIRRSHQKHNAILASIKSSERD 60
MYSQRFGTVQREVKGPTPKVVIVRSKPPKGQGAEHHLERIRRSHQKHNAILASIKSSERD
Sbjct: 1 MYSQRFGTVQREVKGPTPKVVIVRSKPPKGQGAEHHLERIRRSHQKHNAILASIKSSERD 60
Query: 61 RLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNKLRELLALEENEYFTEMQLKK 120
RLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNKLRELLALEENEYFTEMQLKK
Sbjct: 61 RLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNKLRELLALEENEYFTEMQLKK 120
Query: 121 ETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEER 180
ETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEER
Sbjct: 121 ETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEER 180
Query: 181 KAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITS 240
KAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITS
Sbjct: 181 KAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITS 240
Query: 241 IKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQ 300
IKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQ
Sbjct: 241 IKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQ 300
Query: 301 QEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEF 360
QEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEF
Sbjct: 301 QEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEF 360
Query: 361 DRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQK 420
DRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQK
Sbjct: 361 DRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQK 420
Query: 421 HINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAAN 480
HINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAAN
Sbjct: 421 HINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAAN 480
Query: 481 KMCLDKVQEVLSTHQVLPQNIHPMRKACPSKLPP 514
KMCLDKVQEVLSTHQVLPQNIHPMRKACPSKLPP
Sbjct: 481 KMCLDKVQEVLSTHQVLPQNIHPMRKACPSKLPP 514
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 131 bits (329), Expect = 2e-30
Identities = 100/381 (26%), Positives = 200/381 (52%), Gaps = 14/381 (3%)
Query: 95 EERRNKLRELLALEENEYFTEMQ-LKKETIEEKKDRMR-EKTKLLKEKNEKERQDFVAEK 152
EE + REL EE E Q L++E EE++ + R + + L+ K E+ER++ E+
Sbjct: 262 EEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEER 321
Query: 153 LDQQ-FRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLA 211
+QQ RE+ EE R + L Q+ E R+ Q+ +E R+ EQ + EE+R
Sbjct: 322 REQQERREQQEERREQQLRREQE---ERREQQLRREQEEERR----EQQLRREQEEERRE 374
Query: 212 KEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENE 271
++ R Q+ RR+++L +L Q+ + R+ QL +E++ R Q++ E E
Sbjct: 375 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR----REQQLRREQE 430
Query: 272 QDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQK 331
++ +++ ++ L++ +ER + +++E E+ + Q+ +D +EE ++ K
Sbjct: 431 EERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLK 490
Query: 332 REDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVD 391
E+ R ++ + RRE+E+ +E+ R EE++ ++ +++LR E+E RR+ +
Sbjct: 491 LEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLL 550
Query: 392 EVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQL 451
+ ++L+ + + QR +EQEER + E ++ + ++ QRL +E ++L
Sbjct: 551 KREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERL 610
Query: 452 QMQIAYQQQSQEAEKEEKRRE 472
+ + +Q+ + E EE+RR+
Sbjct: 611 EQEERREQRLKREEPEEERRQ 631
Score = 114 bits (285), Expect = 2e-25
Identities = 102/427 (23%), Positives = 215/427 (50%), Gaps = 42/427 (9%)
Query: 95 EERRNKLRELLALEENEYFTEMQLKKETIEEKKDRM----REKTKLLKEKNEKERQ-DFV 149
E R +L L E E QL+ E ++++ R EK + +++ E+E++ F+
Sbjct: 778 ERGRQRLSARPPLREQR---ERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFL 834
Query: 150 AEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQ------MFSK 203
E+ Q RER ++L+ E + + + E R++Q ++ R +L EE+ +++K
Sbjct: 835 EEEEQLQRRERAQQLQEEEDGLQEDQ--ERRRSQEQRRDQKWRWQLEEERKRRRHTLYAK 892
Query: 204 LWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNN 263
+++L KE++ QE + + E + Q + R+ QL +EEE L E
Sbjct: 893 PALQEQLRKEQQLLQEEEEELQREEREKRRRQEQE---RQYREEEQLQQEEEQLLREERE 949
Query: 264 AQIKHENEQDMLKKQKAKQETRTIL-QKALQERIEHIQQEYRDEQDLNMKLVQ------- 315
+ + E E+ K +K +Q+ +L ++ + R + +++YR+E++L + Q
Sbjct: 950 KRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREERE 1009
Query: 316 -RALQDLQEEADKK---KQKREDMIREQKIYHKYLA---QRREEEKAQEKEFDRILEEDK 368
R Q+ + + KK +Q+ E ++RE++ + Q REEE+ Q++E + EE +
Sbjct: 1010 KRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERE 1069
Query: 369 AKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKE 428
++ E +++ R E+E +++ +L +E +R +E+E + E++ + + ++
Sbjct: 1070 TRRRQELERQYRKEEELQQE-------EEQLLREEPEKRRRQERERQCREEEELQQEEEQ 1122
Query: 429 LNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQ 488
L EE+E RRQ L ++YR++ ++Q +Q +E ++ +R+E E + + +
Sbjct: 1123 LLREEREK-RRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEE 1181
Query: 489 EVLSTHQ 495
++L Q
Sbjct: 1182 QLLREEQ 1188
Score = 112 bits (280), Expect = 8e-25
Identities = 104/400 (26%), Positives = 204/400 (51%), Gaps = 42/400 (10%)
Query: 95 EERRNKLREL--LALEENEYFTEMQLKKETIE-----EKKDRMR-EKTKLLKEKNEKERQ 146
+ER K RE L EE + E + K+ E KKD ++ E+ +LL+E+ EK R
Sbjct: 984 QEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRR- 1042
Query: 147 DFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWE 206
++ ++Q+RE EEL+ E ++ + EER+ + +EL RQ EE++ + +
Sbjct: 1043 ---LQERERQYREE-EELQQE----EEQLLGEERETRR--RQELERQYRKEEELQQEEEQ 1092
Query: 207 EDRLAKEKREAQEARRQ----KELMENTRLGLNAQITSIKAQ------RQATQLLKEEEA 256
R EKR QE RQ +EL + L + + Q R+ ++ +EEE
Sbjct: 1093 LLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQ 1152
Query: 257 RLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQR 316
L E + + E E+ ++++ +QE +L++ ++R + +++YR+E++L + ++
Sbjct: 1153 LLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQ 1212
Query: 317 ALQDLQEEADKKKQ---KREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLA 373
+D + +D K Q ++E+ +R+ K+Y K + + + DR ++D L
Sbjct: 1213 RYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLG 1272
Query: 374 EKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEE 433
E+ + R E+E RR + + Q++ + Q+EAK ++ ++ E+ K+L EE
Sbjct: 1273 EQQERDR-EQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEE-------KQLLREE 1324
Query: 434 KENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREF 473
+E RRQ +++R+ + Q+ +++ Q ++E+ R+F
Sbjct: 1325 REEKRRRQETDRKFRE--EEQLLQEREEQPLRRQERDRKF 1362
Score = 111 bits (277), Expect = 2e-24
Identities = 114/495 (23%), Positives = 225/495 (45%), Gaps = 62/495 (12%)
Query: 24 RSKPPKGQGAEHHLERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARI 83
R + K Q E L++ RS Q+ ++ + +R + + + ++ R+
Sbjct: 515 REQRLKRQEEEERLQQRLRSEQQ-------LRREQEERREQLLKREEEKRLEQERREQRL 567
Query: 84 KDAVQGFIINIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEK 143
K + + +R + R+ E E E +LK+E +E + R + +L +E+ E+
Sbjct: 568 KREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEE 627
Query: 144 ERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSK 203
ER+ + + +Q EER+ Q E+ R+ EQ +
Sbjct: 628 ERRQQLLKSEEQ----------------------EERRQQQLRREQQERR----EQRLKR 661
Query: 204 LWEEDRLAKE-KREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESN 262
EE+RL + KRE +E RR++EL E + +I S + + QL E +AR +
Sbjct: 662 EEEEERLEQRLKREHEEERREQELAEEEQEQARERIKS-RIPKWQWQLESEADARQSKVY 720
Query: 263 NAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQE-----------------YRD 305
+ K E ++ ++++ ++ + LQ +ER QQE R
Sbjct: 721 SRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERG 780
Query: 306 EQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQE--KEFDRI 363
Q L+ + R ++ Q A++++Q+ + + E++ + QRRE EK + +E +++
Sbjct: 781 RQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQL 840
Query: 364 LEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKE-------QEERA 416
++A++L E++ L+ ++E RR + Q++E+ +R QE+
Sbjct: 841 QRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLR 900
Query: 417 MEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAG 476
EQ+ + E +EL EE+E RRQ ++YR++ Q+Q +Q +E ++ +R+E E
Sbjct: 901 KEQQLLQEEEEELQREEREK-RRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQ 959
Query: 477 VAANKMCLDKVQEVL 491
+K K +++L
Sbjct: 960 YRKDKKLQQKEEQLL 974
Score = 110 bits (276), Expect = 2e-24
Identities = 120/482 (24%), Positives = 234/482 (48%), Gaps = 60/482 (12%)
Query: 24 RSKPPKGQGAEHHLE-RIRRSHQ---KHNAILASIKSSERDRLKA-----EWDQHNDCKI 74
R + K + E LE R++R H+ + + + R+R+K+ +W ++
Sbjct: 655 REQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADA 714
Query: 75 LDSLVRARI-KDAVQGFIINIEERRNKLRELLALEENEYFTEMQLKKET---------IE 124
S V +R K Q EE+R + L +E E Q ++E E
Sbjct: 715 RQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAE 774
Query: 125 EKKDRMREKTKL---LKEKNEKERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERK 181
EK +R R++ L+E+ E++ + ++ +Q+F EE +++ ER+
Sbjct: 775 EKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKE------QRRRQRRERE 828
Query: 182 AQIAFNEELSR-------QKLVEEQMFSKLWEEDRLAKEKREAQEARRQ-KELMENTRLG 233
++ F EE + Q+L EE+ + +E R ++E+R Q+ R Q +E + R
Sbjct: 829 KELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHT 888
Query: 234 LNAQITSIKAQRQATQLLKEEEARLV-ESNNAQIKHENEQDMLKKQKAKQETRTILQKAL 292
L A+ + R+ QLL+EEE L E + + E E+ ++++ +QE +L+
Sbjct: 889 LYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLR--- 945
Query: 293 QERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREE 352
+ER + +QE + + KL Q+ Q L EE +K++++ RE+K REE
Sbjct: 946 EEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQE----REKKY--------REE 993
Query: 353 EKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQ 412
E+ Q++E + EE + ++ E +++ R + E +++ +L +E+ +R +E+
Sbjct: 994 EELQQEEEQLLREEREKRRRQEWERQYRKKDELQQE-------EEQLLREEREKRRLQER 1046
Query: 413 EERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRRE 472
E + E++ + + ++L EE+E RRQ L ++YRK+ ++Q +Q +E ++ +R+E
Sbjct: 1047 ERQYREEEELQQEEEQLLGEERET-RRRQELERQYRKEEELQQEEEQLLREEPEKRRRQE 1105
Query: 473 FE 474
E
Sbjct: 1106 RE 1107
Score = 110 bits (275), Expect = 3e-24
Identities = 103/407 (25%), Positives = 206/407 (50%), Gaps = 59/407 (14%)
Query: 96 ERRNKLRELLALEENEYFT------EMQLKKETIEEKKDRMREKTKL--------LKEKN 141
+RR + +EL LEE E ++Q +++ ++E ++R R + + L+E+
Sbjct: 823 QRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEER 882
Query: 142 EKERQDFVAEK-LDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQM 200
++ R A+ L +Q R+ + L+ E + Q++ E+R+ Q E RQ EEQ+
Sbjct: 883 KRRRHTLYAKPALQEQLRKEQQLLQEEEEEL-QREEREKRRRQ-----EQERQYREEEQL 936
Query: 201 FSKLWEEDRLAKEKREAQEARRQ----KELMENTRLGLNAQITSIKAQ------RQATQL 250
+ + R +EKR QE RQ K+L + L + + Q R+ +L
Sbjct: 937 QQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEEL 996
Query: 251 LKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQER-IEHIQQEYRDEQDL 309
+EEE L E + + E E+ KK + +QE +L++ ++R ++ +++YR+E++L
Sbjct: 997 QQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEEL 1056
Query: 310 NMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKA 369
QEE ++RE R Q++ +Y R+EE+ Q++E + EE +
Sbjct: 1057 Q-----------QEEEQLLGEERETR-RRQELERQY----RKEEELQQEEEQLLREEPEK 1100
Query: 370 KKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKEL 429
++ E++++ R E+E +++ +L +E+ +R +E E + E++ + + ++L
Sbjct: 1101 RRRQERERQCREEEELQQE-------EEQLLREEREKRRRQELERQYREEEEVQQEEEQL 1153
Query: 430 NCEEKENFARRQRLAQEYRKQLQMQIAYQQ---QSQEAEKEEKRREF 473
EE E RRQ L ++YR++ ++Q +Q + QE ++E+ R++
Sbjct: 1154 LREEPEK-RRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQY 1199
Score = 106 bits (265), Expect = 4e-23
Identities = 91/371 (24%), Positives = 193/371 (52%), Gaps = 26/371 (7%)
Query: 96 ERRNKLRELLALEENEYFTEMQLKKETIEEKKDR-MREKTKLLKEKNEKERQDFVAE--- 151
E+ + + L E+ E E QL++E EE++++ +R + +L +E+ + Q E
Sbjct: 342 EQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQL 401
Query: 152 KLDQQFRERCEELRVELLSIHQ--KKVCEERKAQIAFNEELSRQKLVEEQMFSKLW---- 205
+ +QQ R + R + L Q ++ EE + + +E Q+L EQ + W
Sbjct: 402 RREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKRE 461
Query: 206 -EEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNA 264
E +R +E+R+ Q R Q+E L L + + +R+ QL +E+E E
Sbjct: 462 EETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQE----ERREQ 517
Query: 265 QIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEE 324
++K + E++ L+++ ++ Q+ +E++ ++E R EQ+ + ++R QEE
Sbjct: 518 RLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKRE----QEE 573
Query: 325 ADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKE 384
+ KRE+ R+Q++ K + R E++ + +E +R+ +E++ ++ ++++ E+E
Sbjct: 574 RRDQLLKREEERRQQRL--KREQEERLEQRLKREEVERLEQEERREQRLKREEP---EEE 628
Query: 385 ARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLA 444
R+QL+ ++ + Q++L+RE +E+ E+ ++++ E L++ E E R Q LA
Sbjct: 629 RRQQLLKSE--EQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELA 686
Query: 445 QEYRKQLQMQI 455
+E ++Q + +I
Sbjct: 687 EEEQEQARERI 697
Score = 106 bits (265), Expect = 4e-23
Identities = 108/483 (22%), Positives = 234/483 (48%), Gaps = 62/483 (12%)
Query: 38 ERIRRSHQKHNAILAS--IKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIE 95
+R+RR ++ + ++ ER++ + Q D K + + ++ + F +
Sbjct: 1381 QRLRRQERERKFLKEEQQLRCQEREQ---QLRQDRDRKFREEEQQLSRQERDRKFREEEQ 1437
Query: 96 ERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEK----ERQDFVAE 151
+ R + RE LEE + + + +K EE+ + RE+ +L +++ ++ E Q +
Sbjct: 1438 QVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQ 1497
Query: 152 KLDQQFRE---RCEELRVELLSIHQKKVCEERKAQIAFNEE-LSRQKLVEEQMFS---KL 204
+ D++FRE R +E + L Q+ ++R+ + E+ L RQ+ +++ K
Sbjct: 1498 ERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKF 1557
Query: 205 WEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNA 264
EE++L +E+ E Q +R++++ + L Q ++ Q Q + +++E+ +
Sbjct: 1558 REEEQLRQEREEQQLSRQERD----RKFRLEEQ--KVRRQEQERKFMEDEQQLRRQEGQQ 1611
Query: 265 QIKHENEQDMLKKQKAKQET-----------RTILQKALQERIEHIQQEYRDEQDLNMKL 313
Q++ E ++ + ++ QE R L++ Q R + +Q+ R ++D +
Sbjct: 1612 QLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFRE 1671
Query: 314 VQRALQDLQE------EADKKKQKREDMIREQKIYHKYLAQ-------------RREEEK 354
++ LQ+ +E E D+K ++ E +R Q+ K+L + R EE+
Sbjct: 1672 EEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQL 1731
Query: 355 AQEKEFDRILEEDKAKKLAEKD--KELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQ 412
QE E +++ +++ +K+ E++ + R E++ RRQ D RK + +E+L++E +EQ
Sbjct: 1732 RQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERD-----RKFREEEQLRQEREEQ 1786
Query: 413 EERAMEQKHINESLKELNCEEKENFARRQRLAQEYR---KQLQMQIAYQQQSQEAEKEEK 469
+ R+ E ++L E +E R Q+ +YR +QLQ++ Q+ QE +++ +
Sbjct: 1787 QLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYR 1846
Query: 470 RRE 472
E
Sbjct: 1847 AEE 1849
Score = 105 bits (263), Expect = 8e-23
Identities = 96/381 (25%), Positives = 193/381 (50%), Gaps = 40/381 (10%)
Query: 115 EMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRERCEELRVELLSIHQK 174
+ QL++E + ++ + +E+ + L E E+ + E+L+Q+ R+R +E EL Q+
Sbjct: 126 DRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQ---ERLEQRDRQRRDE---ELW--RQR 177
Query: 175 KVCEERKAQIAFNEELSRQKLVEEQMF--------SKLWEEDRLAKEKREAQEARRQKEL 226
+ +ER+ + A E+L K E + F +L E R +E+++ Q RQ +
Sbjct: 178 QEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRV 237
Query: 227 MENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRT 286
+ + +++ T L KEEE E Q + + E++ L+K + ++ R
Sbjct: 238 FQEEE--------EKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRE 289
Query: 287 ILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMI-REQKIYHKY 345
++ Q++ +Q+ R +Q+ + Q ++ QE ++++++RE + REQ+ +
Sbjct: 290 RQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQ 349
Query: 346 LAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARR--QLVDEVMCTRKLQV-- 401
+R +EE+ +E++ R EE++ ++ ++++LR E++ RR QL E R+ Q+
Sbjct: 350 QLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 409
Query: 402 QEKLQRE---------AKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQ 452
+++L+RE +EQEE EQKH E ++ E+E RR L +E +
Sbjct: 410 EQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEE--RRDWLKREEETERH 467
Query: 453 MQIAYQQQSQEAEKEEKRREF 473
Q +QQ + ++EE+R +
Sbjct: 468 EQERRKQQLKRDQEEERRERW 488
Score = 105 bits (262), Expect = 1e-22
Identities = 107/424 (25%), Positives = 211/424 (49%), Gaps = 62/424 (14%)
Query: 102 RELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLK--EKNEKERQDFVAEKLDQQFRE 159
RE E + E QL++E EE+ ++ E+ + + ++ ++ER+D++ K +++
Sbjct: 409 REQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWL--KREEETER 466
Query: 160 RCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKEKREAQE 219
+E R + L Q++ ER ++ EE Q+ EQ + EE R + KR+ +E
Sbjct: 467 HEQERRKQQLKRDQEEERRERWLKLE-EEERREQQERREQQLRREQEERREQRLKRQEEE 525
Query: 220 ARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQ-IKHENEQ---DML 275
R Q+ RL Q+ + +R+ L +EEE RL + Q +K E E+ +L
Sbjct: 526 ERLQQ------RLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLL 579
Query: 276 KKQKAKQETRT-------ILQKALQERIEHIQQEYRDEQDLNM-KLVQRALQDLQEEADK 327
K+++ +++ R + Q+ +E +E ++QE R EQ L + + Q L + ++
Sbjct: 580 KREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQ 639
Query: 328 KKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEED-KAKKLAEKDKE-------- 378
++++++ + REQ+ + +R EEE+ E+ R EE+ + ++LAE+++E
Sbjct: 640 EERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKS 699
Query: 379 --------LRLEKEARRQLV------DEVMCTRKLQVQEKLQREAK---EQEERAMEQKH 421
L E +AR+ V E R+ Q +++ +RE++ ++EERA Q+
Sbjct: 700 RIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQ 759
Query: 422 INESLKELNCE---EKENFARRQRLAQE--YRKQLQMQIAYQQQSQ--------EAEKEE 468
E ++ + E+++ RQRL+ R+Q + Q+ +++ Q E EKE+
Sbjct: 760 EEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQ 819
Query: 469 KRRE 472
+RR+
Sbjct: 820 RRRQ 823
Score = 102 bits (254), Expect = 8e-22
Identities = 108/449 (24%), Positives = 216/449 (48%), Gaps = 59/449 (13%)
Query: 39 RIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAV--QGFIINIEE 96
R RR +K L + +R R +A+ Q + + + R R ++ Q + +EE
Sbjct: 822 RQRREREKELQFLEEEEQLQR-RERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEE 880
Query: 97 RRNKLRELL----ALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEK 152
R + R L AL+E + E QL +E EE + REK + +++ + ++ + ++
Sbjct: 881 ERKRRRHTLYAKPALQE-QLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQE 939
Query: 153 LDQQFRERCEELRVELLS--IHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRL 210
+Q RE E+ R + + K ++++ Q+ E R++ E+ + EE+ L
Sbjct: 940 EEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYR---EEEEL 996
Query: 211 AKEK----REAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEE-EARLVESNNAQ 265
+E+ RE +E RR++E R + Q++ QLL+EE E R ++ Q
Sbjct: 997 QQEEEQLLREEREKRRRQEWERQYR-------KKDELQQEEEQLLREEREKRRLQERERQ 1049
Query: 266 IKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEA 325
+ E E ++Q +E T R + ++++YR E++L Q Q L+EE
Sbjct: 1050 YREEEELQQEEEQLLGEERET-------RRRQELERQYRKEEELQ----QEEEQLLREEP 1098
Query: 326 DKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEA 385
+K++++ + Q REEE+ Q++E + EE + ++ E +++ R E+E
Sbjct: 1099 EKRRRQERE------------RQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEV 1146
Query: 386 RRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQ 445
+++ +L +E +R +E E + E++ + + ++L EE+E RRQ +
Sbjct: 1147 QQE-------EEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEK--RRQERER 1197
Query: 446 EYRKQLQMQIAYQQQSQEAEKEEKRREFE 474
+YR++ ++Q Q++ Q E++R + +
Sbjct: 1198 QYREEEELQ--RQKRKQRYRDEDQRSDLK 1224
Score = 101 bits (252), Expect = 1e-21
Identities = 100/444 (22%), Positives = 219/444 (49%), Gaps = 48/444 (10%)
Query: 54 IKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNKLRELLALEENEYF 113
++ ER+R + +Q C+ + +R +D + F ++ + R+ EE +
Sbjct: 1383 LRRQERERKFLKEEQQLRCQEREQQLR---QDRDRKFREEEQQLSRQERDRKFREEEQQV 1439
Query: 114 TEMQLKKETIEEKKDRMREKTKLLKEKN----EKERQDFVAEKLDQQFRERCEELRVELL 169
+ +++ +EE++ +E+ + +E+ E+E Q ++ D++F E ++LR
Sbjct: 1440 RRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLR---- 1495
Query: 170 SIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSK-------LWEEDRLAKEKREAQEAR- 221
Q++ + R+ ++ ++E R+ L EEQ + L EE +L +++R Q +
Sbjct: 1496 --RQERDRKFREQELR-SQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQD 1552
Query: 222 RQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAK 281
R ++ E +L + + Q + + EE+ V + K ++ L++Q+ +
Sbjct: 1553 RDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQK--VRRQEQERKFMEDEQQLRRQEGQ 1610
Query: 282 QETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKI 341
Q+ R + +E + +Q+ R+EQ L+ + +R + L+EE ++Q+RE +R +
Sbjct: 1611 QQLRQERDRKFREDEQLLQE--REEQQLHRQ--ERDRKFLEEEPQLRRQEREQQLRHDRD 1666
Query: 342 YHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQV 401
K+ R EE+ QE E ++ +++ +K E++++LR ++ R+ L +E R
Sbjct: 1667 -RKF---REEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRR---- 1718
Query: 402 QEKLQREAKEQEE--RAMEQKHINESLK--------ELNCEEKENFARRQRLAQEYRKQL 451
++L+R+ +E+E+ + EQ+ + + +L E +E RRQ +++R++
Sbjct: 1719 -QELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEE 1777
Query: 452 QM-QIAYQQQSQEAEKEEKRREFE 474
Q+ Q +QQ + E + K RE E
Sbjct: 1778 QLRQEREEQQLRSQESDRKFREEE 1801
Score = 101 bits (251), Expect = 2e-21
Identities = 94/373 (25%), Positives = 195/373 (52%), Gaps = 24/373 (6%)
Query: 124 EEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQ 183
EEK+ R K LL+++ ++E Q E D+Q E + R QK+ +E++ +
Sbjct: 97 EEKRARCDGKESLLQDRRQEEDQRRF-EPRDRQLEEEPGQRR------RQKR--QEQERE 147
Query: 184 IAFNEELSRQKLVEEQMFSKLWEED--RLAKEKREAQEARRQKELMENTRLGLNAQITSI 241
+A EE S ++ EQ + +E+ R +E +E +E R ++E +++ + G +
Sbjct: 148 LAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCK-GHETEEFPD 206
Query: 242 KAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETR---TILQKALQERIEH 298
+ Q + +LL E R Q + QD + +++ ++E R T+L+K ++ E
Sbjct: 207 EEQLRRRELL---ELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEE 263
Query: 299 IQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREE-EKAQE 357
Q R+ Q+ +L + Q+L+ E +++Q+++ + REQ++ K +RRE+ E+ +E
Sbjct: 264 EPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERRE 323
Query: 358 KEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAM 417
++ R +E++ ++ +++E R E++ RR+ +E R+ Q++ + + E +EQ+ R
Sbjct: 324 QQERREQQEERREQQLRREQEERREQQLRREQEEE---RREQQLRREQEEERREQQLRRE 380
Query: 418 EQKHINESLK-ELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAG 476
+Q + L+ E ++ R Q+L +E + + + Q+ +QQ + E+EE+R E +
Sbjct: 381 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR-EQEEERHEQKHE 439
Query: 477 VAANKMCLDKVQE 489
+ L + QE
Sbjct: 440 QERREQRLKREQE 452
Score = 99.4 bits (246), Expect = 7e-21
Identities = 100/480 (20%), Positives = 221/480 (46%), Gaps = 70/480 (14%)
Query: 23 VRSKPPKGQGAEHHLERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRAR 82
VR + + + E + + H+K ++ E +L Q D K L+ + R
Sbjct: 1439 VRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHR---QERDRKFLEEEQQLR 1495
Query: 83 IKDAVQGFIINIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNE 142
++ + F +E R++ E LEE + Q +++ ++E++ R+ E+ +
Sbjct: 1496 RQERDRKF--REQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQ------ERGQ 1547
Query: 143 KERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFS 202
+ RQD D++FRE E+LR +ER+ Q +E R+ +EEQ
Sbjct: 1548 QRRQD-----RDRKFREE-EQLR------------QEREEQQLSRQERDRKFRLEEQKVR 1589
Query: 203 KLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESN 262
+ +E + +++++ + Q++L + + R+ QLL+E E + +
Sbjct: 1590 RQEQERKFMEDEQQLRRQEGQQQLRQERD----------RKFREDEQLLQEREEQQLHRQ 1639
Query: 263 NAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDE---QDLNMKLVQRALQ 319
K E+ L++Q+ +Q+ R + +E + +Q+ + Q+ + K + Q
Sbjct: 1640 ERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQ 1699
Query: 320 DLQEEADKKKQKREDMIREQKIYHKY-----LAQRREEEKAQEKE-FDRILEEDKAK--- 370
++E ++K + E +R Q++ K+ L Q E+E+ + +E + +ILEE++ +
Sbjct: 1700 LRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPER 1759
Query: 371 -----KLAEKDKELRLEKEARRQLVDEVM----CTRKLQVQEKLQREAKEQEERAM---- 417
+ E+D++ R E++ R++ ++ + RK + +E+L++E +EQ+ R
Sbjct: 1760 EEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDG 1819
Query: 418 ------EQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRR 471
EQ + E + L E + ++ A + + + + Q +Q++ Q+ +E +R+
Sbjct: 1820 KYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERK 1879
Score = 99.0 bits (245), Expect = 9e-21
Identities = 117/465 (25%), Positives = 219/465 (47%), Gaps = 74/465 (15%)
Query: 24 RSKPPKGQGAEHHLERIRRSHQKHNAILAS--IKSSERDRLKAEWDQHNDCKILDSLVRA 81
R +P Q E +R R+ Q+ LA +S +++RL+ Q D + L R
Sbjct: 121 RFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRD----EELWRQ 176
Query: 82 RIKDAVQGFIINIEERRNKLRELLAL---EENEYFTEMQLKKETIEEKKDRMREKTKLLK 138
R + + EERR + +L + E E+ E QL++ + E + + RE+ K
Sbjct: 177 RQEWQER------EERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREE----K 226
Query: 139 EKNEKERQDFV-AEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVE 197
++ +ERQD V E+ ++++R+R LR E E K Q EE RQ+ ++
Sbjct: 227 QQQRRERQDRVFQEEEEKEWRKRETVLRKE-----------EEKLQ---EEEPQRQRELQ 272
Query: 198 EQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEAR 257
E EE++L K +R+ RQ+E + RL Q+ + + + Q +EE R
Sbjct: 273 E-------EEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQ---QEERR 322
Query: 258 LVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHI---QQEYRDEQDLNMKLV 314
+ Q + EQ + ++Q+ ++E + ++ + R + + Q+E R EQ L +
Sbjct: 323 EQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQ 382
Query: 315 QRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAE 374
R Q L+ E ++ +RE +R ++ + RRE++ +E++ R EE++ ++ E
Sbjct: 383 LRREQQLRRE---QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHE 439
Query: 375 KDKE---LRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNC 431
+++ L+ E+E RR + T + + + + Q+ ++QEE E + L
Sbjct: 440 QERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRE--------RWLKL 491
Query: 432 EEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEE--KRREFE 474
EE+E +++R Q+ R++ QE +E+ KR+E E
Sbjct: 492 EEEERREQQERREQQLRRE-----------QEERREQRLKRQEEE 525
Score = 98.6 bits (244), Expect = 1e-20
Identities = 98/447 (21%), Positives = 220/447 (49%), Gaps = 43/447 (9%)
Query: 39 RIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERR 98
R R+S Q +L + +R++ + W Q + + Q + E++
Sbjct: 1259 RDRQSQQDLQHLLGEQQERDREQERRRWQQRD----------RHFPEEEQ--LEREEQKE 1306
Query: 99 NKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFR 158
K R+ + EE + E + +K +E + RE+ +LL+E+ E Q ++ D++FR
Sbjct: 1307 AKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREE---QPLRRQERDRKFR 1363
Query: 159 ERCEELRVELLSIHQ---KKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKEK- 214
E EELR HQ +K EE Q +E R+ L EEQ E +L +++
Sbjct: 1364 E--EELR------HQEQGRKFLEEE--QRLRRQERERKFLKEEQQLRCQEREQQLRQDRD 1413
Query: 215 REAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDM 274
R+ +E +Q E R + ++ Q + + L+EE+ E + K E+ +
Sbjct: 1414 RKFREEEQQLSRQERDRK-FREEEQQVRRQERERKFLEEEQQLRQERHR---KFREEEQL 1469
Query: 275 LKKQKAKQETRTILQKALQERIEHIQQEYRD----EQDLNMKLVQRALQDLQEEADKKKQ 330
L++++ +Q R + E + ++++ RD EQ+L + +R + +++ ++++
Sbjct: 1470 LQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQR 1529
Query: 331 KREDMIREQKIYHKYLAQRREEEKAQE-KEFDRILEEDKAKKLA--EKDKELRLEKEARR 387
+R+ + EQ++ + Q+R +++ ++ +E +++ +E + ++L+ E+D++ RLE++ R
Sbjct: 1530 QRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVR 1589
Query: 388 QLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEY 447
+ E + ++ +++L+R+ +Q+ R + E + L E++ R++R +
Sbjct: 1590 RQEQE---RKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFL 1646
Query: 448 RKQLQMQIAYQQQSQEAEKEEKRREFE 474
++ Q++ ++Q +++ K RE E
Sbjct: 1647 EEEPQLRRQEREQQLRHDRDRKFREEE 1673
Score = 97.4 bits (241), Expect = 3e-20
Identities = 93/406 (22%), Positives = 199/406 (49%), Gaps = 52/406 (12%)
Query: 94 IEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKL 153
+ E R K R Q + E+++ +E+ +LL+E+ EK R+ ++L
Sbjct: 1124 LREEREKRRR-------------QELERQYREEEEVQQEEEQLLREEPEKRRR----QEL 1166
Query: 154 DQQFRERCEELRVE---LLSIHQKKVCEERKAQIAFNEELSRQKLV-----EEQMFSKLW 205
++Q+RE EEL+ E LL Q+K +ER+ Q EEL RQK E+Q W
Sbjct: 1167 ERQYREE-EELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKW 1225
Query: 206 ----EEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLL-------KEE 254
E++ ++ + + R ++ + ++Q+ ++Q+ LL +E+
Sbjct: 1226 QWEPEKENAVRDNKVYCKGRENEQFRQLE----DSQLRDRQSQQDLQHLLGEQQERDREQ 1281
Query: 255 EARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLV 314
E R + + E + + ++++AK+ R ++ R E ++ R E D +
Sbjct: 1282 ERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREE 1341
Query: 315 QRALQDLQEEADKKKQKREDMIREQKIYHKYLAQR--REEEKAQEKEFDR-ILEEDKAKK 371
++ LQ+ +EE ++Q+R+ RE+++ H+ ++ EE++ + +E +R L+E++ +
Sbjct: 1342 EQLLQE-REEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLR 1400
Query: 372 LAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNC 431
E++++LR +++ R+ +E +R Q +++ RE ++Q R ++ E ++L
Sbjct: 1401 CQEREQQLRQDRD-RKFREEEQQLSR--QERDRKFREEEQQVRRQERERKFLEEEQQLRQ 1457
Query: 432 EEKENFARRQRLAQEYRKQ----LQMQIAYQQQSQEAEKEEKRREF 473
E F ++L QE +Q + + ++ Q+ ++E+ R+F
Sbjct: 1458 ERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKF 1503
Score = 97.4 bits (241), Expect = 3e-20
Identities = 100/453 (22%), Positives = 213/453 (47%), Gaps = 49/453 (10%)
Query: 34 EHHLERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRA---RIKDAVQGF 90
E L + R Q H ERDR E +Q + D R R ++ + F
Sbjct: 1466 EEQLLQEREEQQLHR--------QERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKF 1517
Query: 91 IINIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVA 150
+ ++ + R+ L+E + + ++ +++ + RE+ +L + E+E Q
Sbjct: 1518 LEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQL---RQEREEQQLSR 1574
Query: 151 EKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRL 210
++ D++FR +++R + Q++ E + Q+ E Q+ + ++ K E+++L
Sbjct: 1575 QERDRKFRLEEQKVRRQ----EQERKFMEDEQQLRRQEG---QQQLRQERDRKFREDEQL 1627
Query: 211 AKEKREAQEARRQKE---LMENTRLGLNAQITSIKAQR-----QATQLLKEEEARLVESN 262
+E+ E Q R++++ L E +L + ++ R + QLL+E E + +
Sbjct: 1628 LQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQ 1687
Query: 263 NAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQ--- 319
K E+ L++Q+ + R LQ+ Q R + +++++R+E+ L + Q L+
Sbjct: 1688 ERDRKFREEEQQLRRQERE---RKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQE 1744
Query: 320 ---DLQEEADKKKQKREDMIREQKIYHKY-----LAQRREEEKAQEKEFDRILEEDKAKK 371
+ EE + ++ E +R Q+ K+ L Q REE++ + +E DR E++ +
Sbjct: 1745 RYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLR 1804
Query: 372 LAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNC 431
++++LR ++ + +E +L+ QE+ R+ ++++ RA EQ E +
Sbjct: 1805 QEREEQQLRPQQRDGKYRWEEEQL--QLEEQEQRLRQERDRQYRAEEQFATQEKSRR--- 1859
Query: 432 EEKENF-ARRQRLAQEYRKQLQMQIAYQQQSQE 463
EE+E + Q+ QE ++L+ + +QQ +E
Sbjct: 1860 EEQELWQEEEQKRRQERERKLREEHIRRQQKEE 1892
Score = 97.1 bits (240), Expect = 4e-20
Identities = 103/417 (24%), Positives = 206/417 (49%), Gaps = 45/417 (10%)
Query: 96 ERRNKLRELLALEENEYFTEMQLKKETIE------EKKDRMREKTKLLKEKNEKERQDFV 149
ER+ + E L EE + E K+ E E+++ +E+ +LL+E+ EK R+
Sbjct: 1077 ERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRR--- 1133
Query: 150 AEKLDQQFRERCEELRVE----LLSIHQKKVCEERKAQIAFNEELSRQK---LVEEQMFS 202
++L++Q+RE EE++ E L +K+ +E + Q EEL +++ L EEQ
Sbjct: 1134 -QELERQYREE-EEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKR 1191
Query: 203 KLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIK--AQRQATQLLK-EEEARLV 259
+ E + +E+ ++ R+Q+ E+ R L Q K A R K E +
Sbjct: 1192 RQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFR 1251
Query: 260 ESNNAQIKHENEQDMLKKQKAKQETRTILQ--KALQERIEHIQQEYRDEQDLNMKLVQRA 317
+ ++Q++ Q L+ +Q+ R Q + Q+R H +E + E++ K +R
Sbjct: 1252 QLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLERE-EQKEAKRR 1310
Query: 318 LQDLQEEADKKKQKREDMIREQKIYHKY-----LAQRREEEKAQEKEFDR------ILEE 366
+ QEE +++RE+ R Q+ K+ L Q REE+ + +E DR + +
Sbjct: 1311 DRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQ 1370
Query: 367 DKAKKLAEKDKELRLEKEARRQLVDE--VMC-TRKLQVQEKLQREAKEQEERAMEQ---K 420
++ +K E+++ LR ++ R+ L +E + C R+ Q+++ R+ +E+E++ Q +
Sbjct: 1371 EQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDR 1430
Query: 421 HINESLKELNCEEKEN--FARRQRLAQEYRKQL--QMQIAYQQQSQEAEKEEKRREF 473
E +++ +E+E Q+L QE ++ + Q+ +++ Q+ ++E+ R+F
Sbjct: 1431 KFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKF 1487
Score = 97.1 bits (240), Expect = 4e-20
Identities = 100/420 (23%), Positives = 209/420 (49%), Gaps = 51/420 (12%)
Query: 95 EERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLD 154
EE + E L EE E +L+++ EE++ + E+ +LL+E+ EK R+ ++L+
Sbjct: 1113 EEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEE-QLLREEPEKRRR----QELE 1167
Query: 155 QQFRERCEELRVE---LLSIHQKKVCEERKAQIAFNEELSRQKLV-----EEQMFSKLW- 205
+Q+RE EEL+ E LL Q+K +ER+ Q EEL RQK E+Q W
Sbjct: 1168 RQYREE-EELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQ 1226
Query: 206 ---EEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLL-------KEEE 255
E++ ++ + + R ++ + ++Q+ ++Q+ LL +E+E
Sbjct: 1227 WEPEKENAVRDNKVYCKGRENEQFRQLE----DSQLRDRQSQQDLQHLLGEQQERDREQE 1282
Query: 256 ARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQ 315
R + + E + + ++++AK+ R ++ R E ++ R E D + +
Sbjct: 1283 RRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEE 1342
Query: 316 RALQDLQEEADKKKQKREDMIREQKIYHKYLAQR--REEEKAQEKEFDR-ILEEDKAKKL 372
+ LQ+ +EE ++Q+R+ RE+++ H+ ++ EE++ + +E +R L+E++ +
Sbjct: 1343 QLLQE-REEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRC 1401
Query: 373 AEKDKELRLEKEAR---------RQLVDEVMCTRKLQVQ-EKLQREAKEQEERAMEQKH- 421
E++++LR +++ + RQ D + QV+ ++ +R+ E+E++ +++H
Sbjct: 1402 QEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHR 1461
Query: 422 -INESLKELNCEEKENFARRQR------LAQEYRKQLQMQIAYQQQSQEAEKEEKRREFE 474
E + L E++ R++R Q+ R+Q + + +Q+ + E E K E E
Sbjct: 1462 KFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEE 1521
Score = 67.8 bits (164), Expect = 2e-11
Identities = 71/285 (24%), Positives = 139/285 (48%), Gaps = 32/285 (11%)
Query: 102 RELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRERC 161
R+ LEE + +++ ++ + RE+ +LL+E E++ + ++ D++FRE
Sbjct: 1641 RDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLR---RQERDRKFREEE 1697
Query: 162 EELRV---ELLSIHQKKVCEERKAQIAFNEELS-RQKLVEEQM-----FSKLWEEDRLAK 212
++LR E + +++ ++ + F EE RQ+ +EQ+ + K+ EE++L
Sbjct: 1698 QQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRP 1757
Query: 213 EKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQ 272
E+ E Q R++++ ++ +R+ QL +E R Q++ E E+
Sbjct: 1758 EREEQQLRRQERDRKFREE-------EQLRQEREEQQLRSQESDRKFREEE-QLRQEREE 1809
Query: 273 DMLKKQKAKQETR-TILQKALQERIEHIQQE----YR-DEQDLNMKLVQRALQDL-QEEA 325
L+ Q+ + R Q L+E+ + ++QE YR +EQ + +R Q+L QEE
Sbjct: 1810 QQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEE 1869
Query: 326 DKKKQKRE-----DMIREQKIYHKYLAQRREEEKAQEKEFDRILE 365
K++Q+RE + IR Q+ + Q E + + K R+LE
Sbjct: 1870 QKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLE 1914
Score = 56.2 bits (134), Expect = 7e-08
Identities = 61/265 (23%), Positives = 122/265 (46%), Gaps = 20/265 (7%)
Query: 225 ELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQET 284
+L N R+ N + I QA + L E A+ + ++ +L+ ++ +++
Sbjct: 62 DLDSNGRVDFNEFLLFIFKVAQACYYALGQATGLDEEKRARC--DGKESLLQDRRQEEDQ 119
Query: 285 RTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEA--DKKKQKREDMIREQKIY 342
R + Q E Q+ + Q+ +L + Q ++E + +Q+R++ + Q+
Sbjct: 120 RRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQE 179
Query: 343 HKYLAQRREEE------KAQEKEFDRILEEDKAKKLAEKDKELRLEK-EARRQLVDEVMC 395
+ +RR EE K E E E+ + ++L E ++ R EK + RR+ D V
Sbjct: 180 WQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQ 239
Query: 396 TRKLQVQEKLQ-----REAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQ 450
+ + K + E K QEE Q+ + E ++L E++ RR+R +E ++Q
Sbjct: 240 EEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQEL-RRERQEEEQQQQ 298
Query: 451 ---LQMQIAYQQQSQEAEKEEKRRE 472
+ Q+ +Q+ + E++E+RRE
Sbjct: 299 RLRREQQLRRKQEEERREQQEERRE 323
>gi|219803769 trichoplein [Homo sapiens]
Length = 498
Score = 129 bits (325), Expect = 5e-30
Identities = 99/420 (23%), Positives = 213/420 (50%), Gaps = 15/420 (3%)
Query: 63 KAEWDQHNDC-KILDSLVRARIKDAVQGFIINIEERRNKLRELLALEENEYFTEMQLKKE 121
+AEW + + + R ++K+ + ++E RR KLR+L+ E++ E++ +
Sbjct: 51 QAEWSSKTSYQRSMHAYQREKMKEEKRR---SLEARREKLRQLMQEEQDLLARELEELRL 107
Query: 122 TIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERK 181
++ ++ R+RE+ LK E++R+ + L + +++ +LR L +HQK V +
Sbjct: 108 SMNLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWE 167
Query: 182 AQIAFNEELSRQKLVEEQMFSKLWEED-----RLAKEKREAQEARRQKELMENTRLGLNA 236
Q EE +Q+ EQ +K +E + R A E+ +A+E RRQ E L
Sbjct: 168 MQ---KEEKKQQEATAEQE-NKRYENEYERARREALERMKAEEERRQLEDKLQAE-ALLQ 222
Query: 237 QITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERI 296
Q+ +K + LK+E+ L++ + E E+ ++ + K E L+ ++
Sbjct: 223 QMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQL 282
Query: 297 EHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQ 356
Q+ ++E + + +++Q L+ E +RE ++ + + + ++ + E+A+
Sbjct: 283 SRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAR 342
Query: 357 EKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERA 416
E E +L E+ + +++ E E+ AR +L+ EV+ R+ Q+QEK+++ + QEE
Sbjct: 343 EAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESL 402
Query: 417 MEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQ-QSQEAEKEEKRREFEA 475
++ + +L+E+ + ++L +++L+ Q+A ++ Q+ EA+++E+ E EA
Sbjct: 403 KHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEA 462
Score = 91.7 bits (226), Expect = 1e-18
Identities = 98/420 (23%), Positives = 206/420 (49%), Gaps = 40/420 (9%)
Query: 38 ERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEER 97
E RRS + L + E+D L E ++ ++ +L RI++ EE+
Sbjct: 74 EEKRRSLEARREKLRQLMQEEQDLLARELEE---LRLSMNLQERRIREQHGKLKSAKEEQ 130
Query: 98 RNKLRELLALEE----NEYFTEMQL---KKETI---EEKKDRMREKTKLLKEKNEKERQD 147
R + E L E N EM+L +K + E +K+ +++ +++N++ +
Sbjct: 131 RKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENE 190
Query: 148 FVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNE-ELSRQKLVEEQMFSKLWE 206
+ + + R + EE R +L Q + ++ ++ E E ++ K +E + + WE
Sbjct: 191 YERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWE 250
Query: 207 EDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEA--RLVESNNA 264
+RL +E+++ + R++ EL R NAQ++ R+ Q+ +E EA R+++ A
Sbjct: 251 LERLEEERKQMEAFRQKAELGRFLRHQYNAQLS-----RRTQQIQEELEADRRILQ---A 302
Query: 265 QIKHENEQDMLKKQKAKQETRTI--LQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQ 322
++ E+E L + +Q + +++A++E++ Q E E +L M L + A + +
Sbjct: 303 LLEKEDESQRLHLARREQVMADVAWMKQAIEEQL---QLERAREAELQMLLREEAKEMWE 359
Query: 323 E---EADKKKQKREDMI------REQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLA 373
+ E +++ R+ ++ R+Q+I K RR +E++ + I ++ ++LA
Sbjct: 360 KREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELA 419
Query: 374 EKDKELRLE-KEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCE 432
++KE + K AR+Q ++ + R+LQ E Q+E +E+EE A + ++++L + E
Sbjct: 420 RREKEESEKLKSARKQELEAQVAERRLQAWEADQQE-EEEEEEARRVEQLSDALLQQEAE 478
Score = 73.2 bits (178), Expect = 5e-13
Identities = 95/407 (23%), Positives = 185/407 (45%), Gaps = 72/407 (17%)
Query: 151 EKLDQQF-RERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDR 209
++L+QQ R+R +E R+ + R + I +++ Q ++ ++
Sbjct: 14 QRLNQQLARQREQEARLRQQWEQNSRYF--RMSDICSSKQAEWSSKTSYQRSMHAYQREK 71
Query: 210 LAKEKREAQEARRQK--ELM-----------ENTRLGLNAQITSIKAQRQATQLLKEEEA 256
+ +EKR + EARR+K +LM E RL +N Q I+ Q + KEE+
Sbjct: 72 MKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQR 131
Query: 257 RLV---------ESNNAQIK------HE----NEQDMLKKQKAKQET---------RTIL 288
+L+ + NN +++ H+ N +M K++K +QE
Sbjct: 132 KLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEY 191
Query: 289 QKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQE------EADKKKQKREDMIREQKIY 342
++A +E +E ++ E Q + + LQ ++E EA K K+++E++++++
Sbjct: 192 ERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWEL 251
Query: 343 HKYLAQRREEEKAQEK-EFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVM------- 394
+ +R++ E ++K E R L +L+ + ++++ E EA R+++ ++
Sbjct: 252 ERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQ 311
Query: 395 ---CTRKLQVQE-----KLQREAKEQEERAME---QKHINESLKELNCEEKENFARRQRL 443
R+ QV K E + Q ERA E Q + E KE+ E++E R+R
Sbjct: 312 RLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEM-WEKREAEWARERS 370
Query: 444 AQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEV 490
A++ R ++ QQQ QE + E+ RR E + + + ++EV
Sbjct: 371 ARD-RLMSEVLTGRQQQIQE-KIEQNRRAQEESLKHREQLIRNLEEV 415
>gi|14150056 trichoplein [Homo sapiens]
Length = 498
Score = 129 bits (325), Expect = 5e-30
Identities = 99/420 (23%), Positives = 213/420 (50%), Gaps = 15/420 (3%)
Query: 63 KAEWDQHNDC-KILDSLVRARIKDAVQGFIINIEERRNKLRELLALEENEYFTEMQLKKE 121
+AEW + + + R ++K+ + ++E RR KLR+L+ E++ E++ +
Sbjct: 51 QAEWSSKTSYQRSMHAYQREKMKEEKRR---SLEARREKLRQLMQEEQDLLARELEELRL 107
Query: 122 TIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERK 181
++ ++ R+RE+ LK E++R+ + L + +++ +LR L +HQK V +
Sbjct: 108 SMNLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWE 167
Query: 182 AQIAFNEELSRQKLVEEQMFSKLWEED-----RLAKEKREAQEARRQKELMENTRLGLNA 236
Q EE +Q+ EQ +K +E + R A E+ +A+E RRQ E L
Sbjct: 168 MQ---KEEKKQQEATAEQE-NKRYENEYERARREALERMKAEEERRQLEDKLQAE-ALLQ 222
Query: 237 QITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERI 296
Q+ +K + LK+E+ L++ + E E+ ++ + K E L+ ++
Sbjct: 223 QMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQL 282
Query: 297 EHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQ 356
Q+ ++E + + +++Q L+ E +RE ++ + + + ++ + E+A+
Sbjct: 283 SRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAR 342
Query: 357 EKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERA 416
E E +L E+ + +++ E E+ AR +L+ EV+ R+ Q+QEK+++ + QEE
Sbjct: 343 EAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESL 402
Query: 417 MEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQ-QSQEAEKEEKRREFEA 475
++ + +L+E+ + ++L +++L+ Q+A ++ Q+ EA+++E+ E EA
Sbjct: 403 KHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEA 462
Score = 91.7 bits (226), Expect = 1e-18
Identities = 98/420 (23%), Positives = 206/420 (49%), Gaps = 40/420 (9%)
Query: 38 ERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEER 97
E RRS + L + E+D L E ++ ++ +L RI++ EE+
Sbjct: 74 EEKRRSLEARREKLRQLMQEEQDLLARELEE---LRLSMNLQERRIREQHGKLKSAKEEQ 130
Query: 98 RNKLRELLALEE----NEYFTEMQL---KKETI---EEKKDRMREKTKLLKEKNEKERQD 147
R + E L E N EM+L +K + E +K+ +++ +++N++ +
Sbjct: 131 RKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENE 190
Query: 148 FVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNE-ELSRQKLVEEQMFSKLWE 206
+ + + R + EE R +L Q + ++ ++ E E ++ K +E + + WE
Sbjct: 191 YERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWE 250
Query: 207 EDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEA--RLVESNNA 264
+RL +E+++ + R++ EL R NAQ++ R+ Q+ +E EA R+++ A
Sbjct: 251 LERLEEERKQMEAFRQKAELGRFLRHQYNAQLS-----RRTQQIQEELEADRRILQ---A 302
Query: 265 QIKHENEQDMLKKQKAKQETRTI--LQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQ 322
++ E+E L + +Q + +++A++E++ Q E E +L M L + A + +
Sbjct: 303 LLEKEDESQRLHLARREQVMADVAWMKQAIEEQL---QLERAREAELQMLLREEAKEMWE 359
Query: 323 E---EADKKKQKREDMI------REQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLA 373
+ E +++ R+ ++ R+Q+I K RR +E++ + I ++ ++LA
Sbjct: 360 KREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELA 419
Query: 374 EKDKELRLE-KEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCE 432
++KE + K AR+Q ++ + R+LQ E Q+E +E+EE A + ++++L + E
Sbjct: 420 RREKEESEKLKSARKQELEAQVAERRLQAWEADQQE-EEEEEEARRVEQLSDALLQQEAE 478
Score = 73.2 bits (178), Expect = 5e-13
Identities = 95/407 (23%), Positives = 185/407 (45%), Gaps = 72/407 (17%)
Query: 151 EKLDQQF-RERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDR 209
++L+QQ R+R +E R+ + R + I +++ Q ++ ++
Sbjct: 14 QRLNQQLARQREQEARLRQQWEQNSRYF--RMSDICSSKQAEWSSKTSYQRSMHAYQREK 71
Query: 210 LAKEKREAQEARRQK--ELM-----------ENTRLGLNAQITSIKAQRQATQLLKEEEA 256
+ +EKR + EARR+K +LM E RL +N Q I+ Q + KEE+
Sbjct: 72 MKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQR 131
Query: 257 RLV---------ESNNAQIK------HE----NEQDMLKKQKAKQET---------RTIL 288
+L+ + NN +++ H+ N +M K++K +QE
Sbjct: 132 KLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEY 191
Query: 289 QKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQE------EADKKKQKREDMIREQKIY 342
++A +E +E ++ E Q + + LQ ++E EA K K+++E++++++
Sbjct: 192 ERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWEL 251
Query: 343 HKYLAQRREEEKAQEK-EFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVM------- 394
+ +R++ E ++K E R L +L+ + ++++ E EA R+++ ++
Sbjct: 252 ERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQ 311
Query: 395 ---CTRKLQVQE-----KLQREAKEQEERAME---QKHINESLKELNCEEKENFARRQRL 443
R+ QV K E + Q ERA E Q + E KE+ E++E R+R
Sbjct: 312 RLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEM-WEKREAEWARERS 370
Query: 444 AQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEV 490
A++ R ++ QQQ QE + E+ RR E + + + ++EV
Sbjct: 371 ARD-RLMSEVLTGRQQQIQE-KIEQNRRAQEESLKHREQLIRNLEEV 415
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 107 bits (266), Expect = 3e-23
Identities = 97/399 (24%), Positives = 207/399 (51%), Gaps = 45/399 (11%)
Query: 82 RIKDAVQGFIINIEERRNKLRELLALEEN--EYFTEMQLKKETIEEKKDRMREKTKLLKE 139
R ++ +Q + I+E+ K+RE EE E +M+ ++E + EK+++MR + +++ E
Sbjct: 304 RQEEKIQEWEEKIQEQEEKIREQ---EEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE 360
Query: 140 KNEKERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQ 199
K EK R +L++ E+ E++R +H+++ E++ + E++ Q+ +EQ
Sbjct: 361 KEEKMR------RLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQ 414
Query: 200 MFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSI-KAQRQATQLLKEEEARL 258
+K+W ++ +E+ E + +K + ++ +I K Q Q +EE+ R
Sbjct: 415 E-AKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIRE 473
Query: 259 VESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRAL 318
E Q + +EQ+ ++KQ+ K QE H Q+E EQ+ M + +
Sbjct: 474 QEEIWRQKEKMHEQEKIRKQEEKVWR--------QEEKMHDQEEKIREQEEKMWRQEEKI 525
Query: 319 QDLQE---EADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEK 375
++ +E E ++K +++E+M++EQ+ +EEK QE+E R EE K+ E+
Sbjct: 526 REQEEKIREQEEKIREQEEMMQEQEE-----KMGEQEEKMQEQEKMRRQEE----KIREQ 576
Query: 376 DKELRLEKEARRQLVDEVM-CTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEK 434
++++R +KE R+ +++ K++ QE++ +E QEE+ EQ +E CE++
Sbjct: 577 EEKIREQKEKIREQEEKIWEQEEKIREQEEMMQE---QEEKMWEQ-------EEKMCEQE 626
Query: 435 ENF-ARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRRE 472
E + +++ ++ K + ++ +QQ ++ ++ ++ E
Sbjct: 627 EKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 665
Score = 103 bits (256), Expect = 5e-22
Identities = 99/408 (24%), Positives = 219/408 (53%), Gaps = 50/408 (12%)
Query: 107 LEENEYFTEM-QLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRERCEELR 165
+EENE + + Q ++E + ++++++E + ++E+ EK R+ +++ RE+ E++R
Sbjct: 285 VEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQ------EEKIREQEEKMR 338
Query: 166 VELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKEKREAQEARRQKE 225
+ + +K+ R+ ++ + +E ++L EE M+ K E+ R +EK QE R++E
Sbjct: 339 RQEEMMWEKEEKMRRQEEMMWEKEEKMRRL-EEMMWEKE-EKIRELEEKMHEQEKIREQE 396
Query: 226 LMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETR 285
+RQ + ++E+E R + A++ + E+ +++K +++ +
Sbjct: 397 -----------------EKRQEEEKIREQEKR--QEQEAKMWRQEEKIREQEEKIREQEK 437
Query: 286 TILQKALQERI---EHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQK--REDMIR--E 338
+ ++ +E+I E I++E + ++ M + +++ QEE ++K+K ++ IR E
Sbjct: 438 KMWRQ--EEKIHEQEKIREEEKRQEQEEMWRQEEKIRE-QEEIWRQKEKMHEQEKIRKQE 494
Query: 339 QKIYHKYLAQRREEEKAQEKEFDRILEEDKAK----KLAEKDKELRLEKEARRQLVDEVM 394
+K++ + +EEK +E+E +E+K + K+ E+++++R E+E Q +E M
Sbjct: 495 EKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIR-EQEEMMQEQEEKM 553
Query: 395 CTR--KLQVQEKLQRE---AKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRK 449
+ K+Q QEK++R+ +EQEE+ EQK +E E++E ++ + QE +
Sbjct: 554 GEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEE 613
Query: 450 QL--QMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEVLSTHQ 495
++ Q + +Q+ + E+EEK R E + ++ L + +E + HQ
Sbjct: 614 KMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQ 661
Score = 92.4 bits (228), Expect = 9e-19
Identities = 87/401 (21%), Positives = 190/401 (47%), Gaps = 19/401 (4%)
Query: 92 INIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAE 151
+++E RN + + E+N ++Q K + +E +K ++ K LK K E+ +
Sbjct: 205 LSLELYRNTITDEELKEKN---AKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLP-- 259
Query: 152 KLDQQFRERCEELRVELLSIHQKKVC--EERKAQIAFNEELSRQKLVEEQMFSKLWEEDR 209
QQ + + L EL S+ K EE + N++ + +E+ + WEE
Sbjct: 260 --QQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQE-WEEKI 316
Query: 210 LAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHE 269
+E++ ++ + +E E R + R+ +++ E+E ++ + E
Sbjct: 317 QEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKE 376
Query: 270 NEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKK 329
+ L+++ +QE ++ QE + +QE R EQ+ M R + ++E+ +K +
Sbjct: 377 EKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKM---WRQEEKIREQEEKIR 433
Query: 330 QKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQL 389
++ + M R+++ H+ R EE++ +++E R E+ + ++ + KE E+E R+
Sbjct: 434 EQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQ 493
Query: 390 VDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRK 449
++V R+ + + + +EQEE+ Q+ +E E++E ++ + QE +
Sbjct: 494 EEKVW--RQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEE 551
Query: 450 QL-QMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQE 489
++ + + Q+Q + +EEK RE E + K +K++E
Sbjct: 552 KMGEQEEKMQEQEKMRRQEEKIREQEEKIREQK---EKIRE 589
Score = 86.7 bits (213), Expect = 5e-17
Identities = 95/400 (23%), Positives = 199/400 (49%), Gaps = 32/400 (8%)
Query: 122 TIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERK 181
T ++K DR E+ L KE++ + + D++ +E+ +L+ +L ++ E K
Sbjct: 186 TQKKKADRYIEE--LTKERDALSLELYRNTITDEELKEKNAKLQEKL------QLVESEK 237
Query: 182 AQIAFN-----EELSRQKLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNA 236
++I N +L R KL+ Q + E D L KE + A+ Q ++ EN
Sbjct: 238 SEIQLNVKELKRKLERAKLLLPQQQLQA-EADHLGKELQSVS-AKLQAQVEENELWNRLN 295
Query: 237 QITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERI 296
Q K RQ ++ + EE ++ +I+ + E+ +++K +++ + +K +E++
Sbjct: 296 QQQEEKMWRQEEKIQEWEEK--IQEQEEKIREQEEKIREQEEKMRRQEEMMWEK--EEKM 351
Query: 297 EHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQK--REDMIREQKIYHKYLAQRREEEK 354
Q+E E++ M+ ++ + + +E+ + ++K ++ IREQ+ + + RE+EK
Sbjct: 352 RR-QEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEK 410
Query: 355 AQEKEFDRILEEDKAK----KLAEKDKEL-RLEKEARRQLVDEVMCTRKLQVQEKLQREA 409
QE+E +E+K + K+ E++K++ R E++ Q +++ K Q QE++ R+
Sbjct: 411 RQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQ--EKIREEEKRQEQEEMWRQE 468
Query: 410 ---KEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEK 466
+EQEE +++ ++E K EEK + QE + + Q + ++Q+ + E+
Sbjct: 469 EKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQ 528
Query: 467 EEKRREFEAGVAANKMCLDKVQEVLSTHQVLPQNIHPMRK 506
EEK RE E + + + + +E + + Q MR+
Sbjct: 529 EEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRR 568
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 105 bits (261), Expect = 1e-22
Identities = 102/429 (23%), Positives = 220/429 (51%), Gaps = 44/429 (10%)
Query: 82 RIKDAVQGFIINIEERRNKLRELLALEEN--EYFTEMQLKKETIEEKKDRMREKTKLLKE 139
R ++ +Q + I+E+ K+RE EE E +M+ ++E + EK+++MR + +++ E
Sbjct: 304 RQEEKIQEWEEKIQEQEEKIREQ---EEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE 360
Query: 140 KNEKERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIA-FNEELSRQKLVEE 198
K EK R+ ++ E+ E++R Q+++ E++ +I E++ Q+ + E
Sbjct: 361 KEEKMRRQ------EEMMWEKEEKMR------RQEEMMWEKEEKIRELEEKMHEQEKIRE 408
Query: 199 QMFSKLWEEDRLAKEKREAQEAR--RQKELMENTRLGLNAQITSIKAQRQATQLLKEEEA 256
Q + EE +EKR+ QEA+ RQ+E + + Q K RQ ++ ++E+
Sbjct: 409 QEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQ--EKKMWRQEEKIHEQEKI 466
Query: 257 RLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQR 316
R E K + +++M ++++ E I ++ +E++ +++ R +++ V R
Sbjct: 467 REEE------KRQEQEEMWRQEEKIHEQEEIWRQ--KEKMHEQEEKIRKQEEK----VWR 514
Query: 317 ALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKD 376
+ ++E+ +K +++ E M R+++ + REEEK E+E +I EE+K ++ ++D
Sbjct: 515 QEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQE--KIWEEEKRQE--QED 570
Query: 377 KELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKE----QEERAMEQKHINESLKELNCE 432
K R E++ R Q K++ QE+ ++E +E QEE+ EQ+ + +E E
Sbjct: 571 KMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIRE 630
Query: 433 EKENFARRQRLAQEYRKQL--QMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEV 490
++E ++ + QE +++ Q + +Q+ + E+EE E + + + + +E
Sbjct: 631 QEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEK 690
Query: 491 LSTHQVLPQ 499
+ + + Q
Sbjct: 691 IREQEEMMQ 699
Score = 92.8 bits (229), Expect = 7e-19
Identities = 109/480 (22%), Positives = 224/480 (46%), Gaps = 52/480 (10%)
Query: 55 KSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNKLRELLALEENEYFT 114
+ + DR E + D L+ L R I D ++E+ KL+E L L E+E +
Sbjct: 187 QKKKADRYIEELTKERDALSLE-LYRNTITDE------ELKEKNAKLQEKLQLVESEK-S 238
Query: 115 EMQLKKETIEEKKDRMR---EKTKLLKEKNE--KERQDFVAEKLDQQFRE-----RCEEL 164
E+QL + ++ K +R + + +L E + KE Q V+ KL Q E R +
Sbjct: 239 EIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQS-VSAKLQAQVEENELWNRLNQQ 297
Query: 165 RVELLSIHQKKVCE------ERKAQIAFNEELSRQKLVEEQMFSK---LWEEDRLAKEKR 215
+ E + ++K+ E E++ +I EE R++ EE+M + +WE++ + +
Sbjct: 298 QEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQ--EEKMRRQEEMMWEKEEKMRRQE 355
Query: 216 EA-----QEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHEN 270
E ++ RRQ+E+M + Q + + + + L EE+ E Q +
Sbjct: 356 EMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIREL-EEKMHEQEKIREQEEKRQ 414
Query: 271 EQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQ 330
E++ +++Q+ +QE + + +E+I +++ R+++ + ++ + + ++K+Q
Sbjct: 415 EEEKIREQEKRQEQEAKMWRQ-EEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQ 473
Query: 331 KREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKA-----------KKLAEKDKEL 379
++E+M R+++ H+ R++EK E+E +E+K +K+ E+++++
Sbjct: 474 EQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKM 533
Query: 380 RLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEER----AMEQKHINESLKELNCEEKE 435
++E R+ + K+ QEK+ E K QE+ E+K + K EEK
Sbjct: 534 WRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKI 593
Query: 436 NFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEVLSTHQ 495
+R QE + Q + +Q+ + E+EEK RE E + + + +E + +
Sbjct: 594 REQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQE 653
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 104 bits (259), Expect = 2e-22
Identities = 95/405 (23%), Positives = 218/405 (53%), Gaps = 54/405 (13%)
Query: 82 RIKDAVQGFIINIEERRNKLRELLALEEN--EYFTEMQLKKETIEEKKDRMREKTKLLKE 139
R ++ +Q + I+E+ K+RE EE E +M+ ++E + EK+++MR + +++ E
Sbjct: 365 RQEEKIQEWEEKIQEQEEKIREQ---EEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE 421
Query: 140 KNEKERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQ 199
K EK R+ ++ E+ E++R +H+++ E++ + E++ Q+ +EQ
Sbjct: 422 KEEKMRRQ------EEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQ 475
Query: 200 MFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLV 259
+K+W ++ +E+ E + R Q+E K RQ ++ ++E+ R
Sbjct: 476 E-AKMWRQEEKIREQEE--KIREQEE----------------KMWRQEEKIHEQEKIREE 516
Query: 260 ESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQ 319
E K + +++M ++++ +E I ++ +E+I H Q+E +Q+ M + +
Sbjct: 517 E------KRQEQEEMWRQEEKIREQEEIWRQ--KEKI-HEQEEKIRKQEEKMWRQEEKMH 567
Query: 320 DLQE---EADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKD 376
D +E E ++K ++E+ IREQ+ R +EEK +E+E + +++ +K+ E++
Sbjct: 568 DQEEKIREQEEKVWRQEEKIREQEE-----KIREQEEKIREQEE---MTQEQEEKMGEQE 619
Query: 377 KELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKEN 436
+++ E+E + Q +E M ++ +++E+ +++ +EQEE+ EQ+ + + +E E++E
Sbjct: 620 EKM-CEQEEKMQEQEEKMRRQEEKIREQ-EKKIREQEEKIREQEEMMQEQEEKMWEQEEK 677
Query: 437 FARRQRLAQEYRKQLQMQIA--YQQQSQEAEKEEKRREFEAGVAA 479
++ QE ++++ Q ++Q+ + ++EEK +E + + A
Sbjct: 678 MCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEA 722
Score = 101 bits (252), Expect = 1e-21
Identities = 91/396 (22%), Positives = 209/396 (52%), Gaps = 31/396 (7%)
Query: 107 LEENEYFTEM-QLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRERCEELR 165
+EENE + + Q ++E + ++++++E + ++E+ EK R+ +++ RE+ E++R
Sbjct: 346 VEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQ------EEKIREQEEKMR 399
Query: 166 VELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKEKREAQEARRQKE 225
+ + +K+ R+ ++ + +E + + EE M+ K E+ R +EK QE R++E
Sbjct: 400 RQEEMMWEKEEKMRRQEEMMWEKE-EKMRRQEEMMWEKE-EKIRELEEKMHEQEKIREQE 457
Query: 226 LMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETR 285
+ Q K Q Q ++ ++EE + +I+ + E+ +++K ++ +
Sbjct: 458 EKRQEEEKIREQE---KRQEQEAKMWRQEEK--IREQEEKIREQEEKMWRQEEKIHEQEK 512
Query: 286 TILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKY 345
++ QE+ E +QE E+ + + R + + E+ +K +++ E M R+++ H
Sbjct: 513 IREEEKRQEQEEMWRQE---EKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQ 569
Query: 346 LAQRREEEKAQEKEFDRILE-EDKAKKLAEK---DKELRLEKEARRQLVDEVMCTRKLQV 401
+ RE+E+ ++ ++I E E+K ++ EK +E+ E+E + +E MC ++ ++
Sbjct: 570 EEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKM 629
Query: 402 QEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQL--QMQIAYQQ 459
QE+ + + + QEE+ EQ+ K++ E++E ++ + QE +++ Q + +Q
Sbjct: 630 QEQ-EEKMRRQEEKIREQE------KKIR-EQEEKIREQEEMMQEQEEKMWEQEEKMCEQ 681
Query: 460 QSQEAEKEEKRREFEAGVAANKMCLDKVQEVLSTHQ 495
+ + E+EEK R E + ++ L + +E + HQ
Sbjct: 682 EEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQ 717
Score = 94.7 bits (234), Expect = 2e-19
Identities = 86/412 (20%), Positives = 196/412 (47%), Gaps = 16/412 (3%)
Query: 92 INIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAE 151
+++E RN + + E+N ++Q K + +E +K ++ K LK K E+ +
Sbjct: 266 LSLELYRNTITDEELKEKN---AKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLP-- 320
Query: 152 KLDQQFRERCEELRVELLSIHQKKVC--EERKAQIAFNEELSRQKLVEEQMFSKLWEEDR 209
QQ + + L EL S+ K EE + N++ + +E+ + WEE
Sbjct: 321 --QQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQE-WEEKI 377
Query: 210 LAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHE 269
+E++ ++ + +E E R + R+ +++ E+E ++ + E
Sbjct: 378 QEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKE 437
Query: 270 NEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKK 329
+ L+++ +QE ++ QE + +QE R EQ+ M R + ++E+ +K +
Sbjct: 438 EKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKM---WRQEEKIREQEEKIR 494
Query: 330 QKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQL 389
++ E M R+++ H+ R EE++ +++E R E+ + ++ + KE E+E + +
Sbjct: 495 EQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRK 554
Query: 390 VDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRK 449
+E M ++ ++ ++ + + +EQEE+ Q+ +E E++E ++ + QE +
Sbjct: 555 QEEKMWRQEEKMHDQ-EEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEE 613
Query: 450 QL--QMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEVLSTHQVLPQ 499
++ Q + +Q+ + E+EEK R E + + + + +E + + + Q
Sbjct: 614 KMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQ 665
Score = 73.2 bits (178), Expect = 5e-13
Identities = 89/367 (24%), Positives = 176/367 (47%), Gaps = 54/367 (14%)
Query: 178 EERKAQIAFNEELSRQKLVEEQMF---SKLWEEDRLAK-EKREAQ-EARRQKELMENTRL 232
E K + A + EL R + +E++ +KL E+ +L + EK E Q + K +E +L
Sbjct: 258 ELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKL 317
Query: 233 GLNAQITSIKAQRQATQLLKEEEARL---VESNNA--QIKHENEQDMLKKQKAKQETRTI 287
L Q +A +L + A+L VE N ++ + E+ M ++++ QE
Sbjct: 318 LLPQQQLQAEADHLGKEL-QSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEW--- 373
Query: 288 LQKALQERIEHI--QQEYRDEQDLNMKLVQRALQDLQE----------EADKKKQKREDM 335
++ +QE+ E I Q+E EQ+ M+ + + + +E E ++K +++E+M
Sbjct: 374 -EEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEM 432
Query: 336 I--REQKI------YHKYLAQRREEEKAQEKEFDRILE---EDKAKKLAEKDKELRLEKE 384
+ +E+KI H+ R +EEK QE+E R E E +AK +++K E++
Sbjct: 433 MWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 492
Query: 385 ARRQLVDEVMCTRKLQVQEKLQREAKEQEERAM---------------EQKHINESLKEL 429
R Q K+ QEK++ E K QE+ M +++ I+E +++
Sbjct: 493 IREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKI 552
Query: 430 NCEEKENFARRQRL-AQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQ 488
+E++ + + +++ QE + + Q + ++Q+ + E+EEK RE E + + + +
Sbjct: 553 RKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQE 612
Query: 489 EVLSTHQ 495
E + +
Sbjct: 613 EKMGEQE 619
Score = 68.6 bits (166), Expect = 1e-11
Identities = 89/383 (23%), Positives = 183/383 (47%), Gaps = 46/383 (12%)
Query: 162 EELRVEL-LSIHQKKV--CEERKAQIAFNEELSRQKLVEEQ---MFSKLWEEDRLAKEKR 215
E LR EL +H ++ C++ + Q+A K +E + + S+L + + A E
Sbjct: 180 EALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGELE 239
Query: 216 EA--------QEARRQKELMENTRLGLNAQI---TSIKAQRQATQLLKEEEARLVESNNA 264
+A ++A R E + R L+ ++ T + + +E+ +LVES +
Sbjct: 240 QALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKS 299
Query: 265 QIKHENEQDMLKKQKAKQETRTIL--QKALQERIEHIQQEYRDEQDLNMKLVQRALQD-- 320
+I Q +K+ K K E +L Q+ LQ +H+ +E Q ++ KL + ++
Sbjct: 300 EI-----QLNVKELKRKLERAKLLLPQQQLQAEADHLGKEL---QSVSAKLQAQVEENEL 351
Query: 321 ---LQEEADKKKQKREDMIRE--QKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEK 375
L ++ ++K ++E+ I+E +KI + R +EEK +E+E +E+ + EK
Sbjct: 352 WNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEK 411
Query: 376 ---DKELRLEKEARRQLVDEVMCTRKLQV---QEKL--QREAKEQEERAMEQKHINESLK 427
+E+ EKE + + +E+M ++ ++ +EK+ Q + +EQEE+ E++ I E K
Sbjct: 412 MRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEK 471
Query: 428 ELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQS----QEAEKEEKRREFEAGVAANKMC 483
E K + QE + + Q + ++Q+ QE +EE++R+ + + +
Sbjct: 472 RQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEK 531
Query: 484 LDKVQEVLSTHQVLPQNIHPMRK 506
+ + +E+ + + + +RK
Sbjct: 532 IREQEEIWRQKEKIHEQEEKIRK 554
Score = 47.8 bits (112), Expect = 2e-05
Identities = 50/227 (22%), Positives = 98/227 (43%), Gaps = 15/227 (6%)
Query: 23 VRSKPPKGQGAEHHLERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRAR 82
+R + K + E + R + I K E++ + W Q + + + R +
Sbjct: 486 IREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEM---WRQEEKIREQEEIWRQK 542
Query: 83 IKDAVQGFIINIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEK-- 140
K Q I +E + +E ++ E E + K EEK EK + +EK
Sbjct: 543 EKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIR 602
Query: 141 NEKERQDFVAEKLDQQFRERCE-----ELRVELLSIHQKKVCEERKAQIAFNEELSRQKL 195
++E EK+ +Q + CE + + E + ++K+ E+ K E++ Q+
Sbjct: 603 EQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEE 662
Query: 196 VEEQMFSKLWE-EDRLAKEKREAQE----ARRQKELMENTRLGLNAQ 237
+ ++ K+WE E+++ +++ + QE RRQ+E M + L Q
Sbjct: 663 MMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQ 709
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 103 bits (257), Expect = 4e-22
Identities = 100/435 (22%), Positives = 222/435 (51%), Gaps = 46/435 (10%)
Query: 59 RDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNKLRELLALEENEYFTEMQL 118
RD+ + W+Q + + +R + K + E+ K+RE ++E E T Q
Sbjct: 393 RDQEERMWEQDERLREKEERMREQEK---------MWEQVEKMREEKKMQEQEKKTRDQE 443
Query: 119 KK----ETIEEKKDRMREKTKLLKEKNEK--ERQDFVAEKLDQQFRERCEELRVELLSIH 172
+K E I E++ +MRE+ + ++E+ EK ++++ + E+ ++++++ + L + +
Sbjct: 444 EKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQ--QRLPEQKEKLW 501
Query: 173 QKKVCEERKAQIAFNEELSRQKLVEEQMFS---KLWEEDRLAK------EKREAQEARRQ 223
+++ +E++ +I EE R +E+M+ K+W ++++ + E+ E + Q
Sbjct: 502 EQEKMQEQEEKIWEQEEKIRD---QEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQ 558
Query: 224 KELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQE 283
K + R+ Q K Q ++ +EE R E K E++M+++Q+ K +
Sbjct: 559 KMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREK-----KMREEEEMMREQEEKMQ 613
Query: 284 TRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYH 343
+ ++ +QE+ E + ++ Q+ K+ ++ + ++E +Q+R +E+ H
Sbjct: 614 EQ---EEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEH 670
Query: 344 KYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQE 403
+ + +E+EK QE+E ++I E++K +K ++ ++ ++E R+ +K++ +E
Sbjct: 671 EKM---QEQEKMQEQE-EKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEE 726
Query: 404 KLQREAKE----QEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQ 459
++ RE +E QEE+ EQ+ +E E++E +QRL E +++L Q+
Sbjct: 727 EMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRL-PEQKEKLWEHEKMQE 785
Query: 460 QSQEAEKEEKRREFE 474
Q + E+EEK R+ E
Sbjct: 786 QEKIWEQEEKMRDQE 800
Score = 102 bits (253), Expect = 1e-21
Identities = 97/432 (22%), Positives = 225/432 (52%), Gaps = 39/432 (9%)
Query: 92 INIEERRNKLRELLALEENEYFTEMQLKKETIEEK----KDRMREKTKLLKEKNEKE-RQ 146
+N++E + KL E F Q++ T++E+ ++ +RE+ K ++++ EK RQ
Sbjct: 246 LNVKELKRKL-------ERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQ 298
Query: 147 DFVAEKLDQQFRERCEEL-RVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLW 205
+ + + + RE+ E++ R E Q+K E++ ++ +EL Q+ ++ K+W
Sbjct: 299 EERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMW 358
Query: 206 EEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQAT----QLLKEEEARLVES 261
E++ +E+ E + RQ+E + + Q ++ Q + + L+E+E R+ E
Sbjct: 359 EQEEKMREQEE--KMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQ 416
Query: 262 NNAQIKHENEQDMLKKQKAKQETRTILQKALQE-RIEHIQQEYRDEQDL---NMKLVQRA 317
+ E ++ K Q+ +++TR +K +E RI +++ R+E++ + +Q+
Sbjct: 417 EKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQ 476
Query: 318 LQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEE--DKAKKLAEK 375
+++ E+ +K+ Q++ +++K++ + Q +EE+ +++E R EE + KK+ +
Sbjct: 477 EENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQ 536
Query: 376 DK-----ELRLEKEARRQLVDEVMCTRKLQVQEKLQREAK---EQEERAMEQKHINESLK 427
+K + E+E + + ++ M ++ ++++K Q + K +QEE+ E++ + E K
Sbjct: 537 EKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREK 596
Query: 428 ELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKV 487
++ EE+E ++ QE +++Q +Q+ + E+EEK +E E + + + +
Sbjct: 597 KMR-EEEEMMREQEEKMQEQEEKMQ-----EQEEKMWEQEEKMQEQEEKMWEQEEKMWEQ 650
Query: 488 QEVLSTHQVLPQ 499
+E + Q LP+
Sbjct: 651 EEKMWEQQRLPE 662
Score = 98.6 bits (244), Expect = 1e-20
Identities = 99/410 (24%), Positives = 203/410 (49%), Gaps = 33/410 (8%)
Query: 95 EERRNKLRELLALEENEYFTEMQLKKETIEEK----KDRMREKTKLLKEKNEKERQDFVA 150
+E++ + +E + E E + K EEK + R+RE+ K L+E+ ++ R+
Sbjct: 284 QEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKEL 343
Query: 151 EKLDQQFRERCEEL--RVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEED 208
+ ++Q +E+ E++ + E + ++K+ + + +++ Q+ ++WE+D
Sbjct: 344 REQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQD 403
Query: 209 RLAKEKRE-AQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVES---NNA 264
+EK E +E + E +E R Q K + Q ++ +EE R E
Sbjct: 404 ERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEE 463
Query: 265 QIKHENEQDMLKKQKA--KQETRTILQKALQERIEHI-QQEYRDEQDLNMKLVQRALQDL 321
+ E E+ M K+++ +QE + Q+ L E+ E + +QE EQ+ + + ++D
Sbjct: 464 ETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQ 523
Query: 322 QEE-ADKKKQKREDMIREQ--KIYHKYLAQRREEEKA--QEKEFDRILEEDKAK------ 370
+E +KK R++ +REQ +++ + R +E+K QE+ ++ +E + K
Sbjct: 524 EEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEE 583
Query: 371 ------KLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINE 424
++ E++K++R E+E R+ +E M ++ ++QE+ + + EQEE+ EQ+
Sbjct: 584 KMREEERMREREKKMREEEEMMRE-QEEKMQEQEEKMQEQ-EEKMWEQEEKMQEQEEKMW 641
Query: 425 SLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFE 474
+E E++E +QRL E +++L Q+Q + E+EEK E E
Sbjct: 642 EQEEKMWEQEEKMWEQQRL-PEQKEKLWEHEKMQEQEKMQEQEEKIWEQE 690
Score = 98.6 bits (244), Expect = 1e-20
Identities = 86/395 (21%), Positives = 199/395 (50%), Gaps = 29/395 (7%)
Query: 95 EERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLD 154
+E++ + +E ++ E E E + EK++RMRE+ K+ E+ EK R++ ++ +
Sbjct: 381 QEKQMREQEQKMRDQEERMWEQD---ERLREKEERMREQEKMW-EQVEKMREEKKMQEQE 436
Query: 155 QQFRERCEELRVE-LLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKE 213
++ R++ E+++ E + +KK+ EE + E++ +Q+ + K W++ RL ++
Sbjct: 437 KKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQ 496
Query: 214 KREAQEARRQKELMENT-----RLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKH 268
K + E + +E E ++ ++ + + + ++E+E ++ E
Sbjct: 497 KEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQ 556
Query: 269 E----NEQDMLKKQKAKQETRTILQKAL---QERIEHIQQEYRDEQDLNMKLVQRALQDL 321
E ++++ ++K+ +QE +T Q+ +ER+ +++ R+E+++ R ++
Sbjct: 557 EQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEM-----MREQEEK 611
Query: 322 QEEADKKKQKREDMI--REQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKEL 379
+E ++K Q++E+ + +E+K+ + +EEK E+E +++ E+ + + EK E
Sbjct: 612 MQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQE-EKMWEQQRLPEQKEKLWEH 670
Query: 380 RLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFAR 439
+E + E K+ QEK++++ +EQE++ +Q+ + E E+K
Sbjct: 671 EKMQEQEKMQEQE----EKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEE 726
Query: 440 RQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFE 474
QE + Q Q + +Q+ + E+EEK E E
Sbjct: 727 EMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQE 761
Score = 97.8 bits (242), Expect = 2e-20
Identities = 105/408 (25%), Positives = 202/408 (49%), Gaps = 49/408 (12%)
Query: 94 IEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKT--------------KLLKE 139
+ E+ +LRE L E E +MQ ++E + E++++MRE+ K ++E
Sbjct: 330 LREQEKELREQKELREQE--EQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMRE 387
Query: 140 KNEKER-QDFVAEKLDQQFRERCEELRVELLSIHQ-KKVCEERKAQIAFNEELSRQKLVE 197
+ +K R Q+ + D++ RE+ E +R + Q +K+ EE+K Q E+ + + E
Sbjct: 388 QEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQ----EQEKKTRDQE 443
Query: 198 EQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEAR 257
E+M + +R K + E + R Q+E M+ + Q + + Q L E++ +
Sbjct: 444 EKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQ----EEKEWQQQRLPEQKEK 499
Query: 258 LVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRA 317
L E Q + E + +K + ++E +K ++ Q++ EQ+ M+ ++
Sbjct: 500 LWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQK 559
Query: 318 LQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDK 377
+ D +E +KK Q++E +Q+ + REEE+ +E+E EE+ ++ EK +
Sbjct: 560 MWDQEERMEKKTQEQEKKTWDQE------EKMREEERMREREKKMREEEEMMREQEEKMQ 613
Query: 378 ELRLEKEARRQLVDEVMCTRKLQVQEKLQR----EAK--EQEERAMEQKHINESLKELNC 431
E +E + Q +E M ++ ++QE+ ++ E K EQEE+ EQ+ + E ++L
Sbjct: 614 E----QEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWE 669
Query: 432 EEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEK----EEKRREFEA 475
EK + Q QE +++ Q ++++QE EK +EK RE E+
Sbjct: 670 HEK---MQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEES 714
Score = 89.0 bits (219), Expect = 1e-17
Identities = 94/397 (23%), Positives = 182/397 (45%), Gaps = 57/397 (14%)
Query: 96 ERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQ 155
E K R+ L+LE + E +++K ++EK L E + E Q V E
Sbjct: 200 EELTKERDALSLE----LYRNTITNEELKKKNAELQEKLPLA-ESEKSEIQLNVKE---- 250
Query: 156 QFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKEKR 215
+ + E + L + + EE Q EEL Q+ + K+W ++ +E+
Sbjct: 251 -LKRKLERAKFLLPQVQTNTLQEEMWRQ---EEELREQEKKIRKQEEKMWRQEERLREQE 306
Query: 216 EAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDML 275
+ +K + RL R+ + L+E+E L E + + E Q+
Sbjct: 307 GKMREQEEKMWRQEKRL------------REQEKELREQEKELREQKELREQEEQMQEQE 354
Query: 276 KKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQE---EADKKKQKR 332
+K ++E + QE Q+E EQ+ M+ ++ ++D +E E D++ +++
Sbjct: 355 EKMWEQEE-----KMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREK 409
Query: 333 EDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAK---KLAEKDKELRLEKEARRQL 389
E+ +REQ+ + + + REE+K QE+E +E+K + ++ E++K++R E+E R+
Sbjct: 410 EERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQ 469
Query: 390 VDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEK------------ENF 437
+ K+Q QE+ EQEE+ +Q+ + E ++L +EK E
Sbjct: 470 EE------KMQKQEE---NMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKI 520
Query: 438 ARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFE 474
++ + + +K + + +Q+ Q E+EEK R+ E
Sbjct: 521 RDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQE 557
Score = 89.0 bits (219), Expect = 1e-17
Identities = 102/456 (22%), Positives = 208/456 (45%), Gaps = 57/456 (12%)
Query: 38 ERIRRSHQKHNAILASIKSSERDRLKAE---WDQHNDCKILDSLVRARIKDAVQGFIINI 94
ERIR +K +++ E K E W+Q L + K Q +
Sbjct: 450 ERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQ 509
Query: 95 EERRNKLRELLALEENEYFTEMQL-KKETIEEKKDRMREKTKLLKEKNEK-----ERQDF 148
EE+ + E + +E + E ++ ++E + E++D+M E+ + ++++ +K ER +
Sbjct: 510 EEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEK 569
Query: 149 VAEKLDQQFRERCEELRVE-LLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEE 207
++ +++ ++ E++R E + +KK+ EE + E++ Q+ ++ K+WE+
Sbjct: 570 KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQ 629
Query: 208 DRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIK 267
+ +E+ E + +K + ++ E+ RL E +
Sbjct: 630 EEKMQEQEEKMWEQEEKMWEQEEKMW--------------------EQQRLPEQKEKLWE 669
Query: 268 HENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADK 327
HE Q+ K Q+ QE + Q+ ++++ + +++ D++ + ++ E +K
Sbjct: 670 HEKMQEQEKMQE--QEEKIWEQEKMEKKTQEQEKKTWDQEKMRE-------EESMREREK 720
Query: 328 KKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARR 387
K ++ E+M+REQ+ + +EEK QE+E + +E+K + EK E + E +
Sbjct: 721 KMREEEEMMREQEE-----KMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKE 775
Query: 388 QLVDEVMCTRKLQVQEKL---QREAKEQEE--RAMEQKHINESLKELNCEEKENFARRQR 442
+L + K+Q QEK+ + + ++QEE R E+K + K EEK +
Sbjct: 776 KLWEH----EKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKM 831
Query: 443 LAQEYRKQLQMQIAYQQQSQEAEK----EEKRREFE 474
QE + Q + + Q+ + EK EEK RE E
Sbjct: 832 WGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQE 867
Score = 85.1 bits (209), Expect = 1e-16
Identities = 83/351 (23%), Positives = 176/351 (50%), Gaps = 27/351 (7%)
Query: 96 ERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQ 155
E+ K+R+ E+ + E +++K+T E++K ++ K+ +E+ +ER+ + E+ ++
Sbjct: 548 EQEEKMRDQ---EQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREE-EE 603
Query: 156 QFRERCEELRV--ELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKE 213
RE+ E+++ E + ++K+ E+ + E++ Q+ + K+WE+ RL ++
Sbjct: 604 MMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQ 663
Query: 214 KR---EAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVES-NNAQIKHE 269
K E ++ + Q+++ E + K Q Q + +E+ R ES + K
Sbjct: 664 KEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMR 723
Query: 270 NEQDMLKKQKAKQETRTILQKALQERIEHI--QQEYRDEQDLNMKLVQRALQDLQEEADK 327
E++M+++Q+ K + + ++ +QE+ E + Q+E EQ+ M QR E +
Sbjct: 724 EEEEMMREQEEKMQEQ---EEKMQEQEEEMWEQEEKMWEQEEKMWEQQRL-----PEQKE 775
Query: 328 KKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEK---DKELRLEKE 384
K + E M ++KI+ + R +EEK + +E +E+K + EK +E +E
Sbjct: 776 KLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQE 835
Query: 385 ARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKE 435
+ +E M ++ +++EK+Q QEE+ EQ+ +E E++E
Sbjct: 836 EKMWGQEEKMWGQEEKMEEKMQG----QEEKMREQEEKMRGQEEKMREQEE 882
Score = 79.0 bits (193), Expect = 1e-14
Identities = 76/366 (20%), Positives = 181/366 (49%), Gaps = 33/366 (9%)
Query: 59 RDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNKLRELLALEENEYFTEMQL 118
RD+ + WDQ R++ Q ++ K+RE + E E +M+
Sbjct: 554 RDQEQKMWDQEE-----------RMEKKTQEQEKKTWDQEEKMREEERMRERE--KKMRE 600
Query: 119 KKETIEEKKDRMREKTKLLKEKNEKE-RQDFVAEKLDQQFRERCEELRVELLSIHQKKVC 177
++E + E++++M+E+ + ++E+ EK Q+ ++ +++ E+ E++ + + +++
Sbjct: 601 EEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRL 660
Query: 178 EERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQ 237
E+K ++ +E++ Q+ ++EQ K+WE++++ K+ +E ++ +E M +
Sbjct: 661 PEQKEKLWEHEKMQEQEKMQEQE-EKIWEQEKMEKKTQEQEKKTWDQEKMREEESMRERE 719
Query: 238 ITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIE 297
K R+ ++++E+E ++ E + E E +++ +QE + Q+ L E+ E
Sbjct: 720 ----KKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKE 775
Query: 298 HIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMI-REQKIYHKYLAQRREEEKAQ 356
+ + + ++ + + E+ +K + + E M +E+K+ + R +EEK
Sbjct: 776 KLWEHEKMQEQ----------EKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMW 825
Query: 357 EKEFDRILEEDKAKKLAEK--DKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEE 414
+E +E+K EK +E ++E++ + Q K++ QE+ RE +E++
Sbjct: 826 GQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMRE-QEEKM 884
Query: 415 RAMEQK 420
R E+K
Sbjct: 885 RGQEEK 890
Score = 70.5 bits (171), Expect = 4e-12
Identities = 64/288 (22%), Positives = 134/288 (46%), Gaps = 29/288 (10%)
Query: 242 KAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIE-HIQ 300
KA R +L KE +A +E I +E LKK+ A+ + + L ++ + I+ +++
Sbjct: 194 KADRYIEELTKERDALSLELYRNTITNEE----LKKKNAELQEKLPLAESEKSEIQLNVK 249
Query: 301 QEYRDEQDLNMKLVQ-----------RALQDLQEEADKKKQKREDMIREQKIYHKYLAQR 349
+ R + L Q R ++L+E+ K +++ E M R+++ + +
Sbjct: 250 ELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKM 309
Query: 350 REEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREA 409
RE+E+ ++ R+ E++K +L E++KELR +KE R Q K+ QE+ RE
Sbjct: 310 REQEEKMWRQEKRLREQEK--ELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQ 367
Query: 410 KE-----------QEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQ 458
+E QE++ EQ+ +E E+ E ++ +E K + +
Sbjct: 368 EEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMR 427
Query: 459 QQSQEAEKEEKRREFEAGVAANKMCLDKVQEVLSTHQVLPQNIHPMRK 506
++ + E+E+K R+ E + + ++ +++ + + + M+K
Sbjct: 428 EEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQK 475
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 97.1 bits (240), Expect = 4e-20
Identities = 83/407 (20%), Positives = 207/407 (50%), Gaps = 39/407 (9%)
Query: 92 INIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAE 151
+++E RN + + E+N ++Q K + +E +K ++ K LK K E+ +
Sbjct: 193 LSLELYRNTITDEELKEKN---AKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLP-- 247
Query: 152 KLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLA 211
QQ + + L EL S+ K +AQ+ NE +R + +Q K+W ++
Sbjct: 248 --QQQLQAEADHLGKELQSVSAKL-----QAQVEENELWNR---LNQQQEEKMWRQEEKI 297
Query: 212 KEKREAQEARRQKELMENTRLGLNAQITSIKAQ--RQATQLLKEEEARLVESNNAQIKHE 269
+E+ E + + +K + ++ ++ K + R+ +++ E+E ++ E + E
Sbjct: 298 QEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQE 357
Query: 270 NEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKK 329
++ +K++ +++ R ++ QE Q+E EQ+ ++ + +Q+ +E+ +++
Sbjct: 358 KIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQE 417
Query: 330 QKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQL 389
+K + +E+++ + RR+EEK +E+E KK+ E+++++R ++E ++
Sbjct: 418 EKMWE--QEEEMQEQEEKMRRQEEKIREQE----------KKIREQEEKIREQEEMMQEQ 465
Query: 390 VDEV------MCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRL 443
+++ MC ++ ++QE+ ++ +++E+ ++K I E +++ +E+ + +++
Sbjct: 466 EEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKM 525
Query: 444 AQEYRKQLQMQIAYQQQSQEAEK-EEKRREFEAGVAANKMCLDKVQE 489
++ K + + Q+Q ++ + EEK RE E + + +K+QE
Sbjct: 526 WEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQE---EKMQE 569
Score = 79.0 bits (193), Expect = 1e-14
Identities = 83/386 (21%), Positives = 192/386 (49%), Gaps = 48/386 (12%)
Query: 122 TIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERK 181
T ++K DR E+ L KE++ + + D++ +E+ +L+ +L ++ E K
Sbjct: 174 TQKKKADRYIEE--LTKERDALSLELYRNTITDEELKEKNAKLQEKL------QLVESEK 225
Query: 182 AQIAFN-----EELSRQKLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNA 236
++I N +L R KL+ Q + E D L KE + A+ Q ++ EN
Sbjct: 226 SEIQLNVKELKRKLERAKLLLPQQQLQA-EADHLGKELQSVS-AKLQAQVEEN------- 276
Query: 237 QITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERI 296
++ + Q+Q ++ ++EE ++ +I+ + E+ +++K +++ + +K +E++
Sbjct: 277 ELWNRLNQQQEEKMWRQEEK--IQEREEKIQEQEEKIREQEEKMRRQEEMMWEK--EEKM 332
Query: 297 EHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQ 356
Q+E E++ + R L++ E +K +++ E E+KI RE+EK Q
Sbjct: 333 RR-QEEMMWEKEEKI----RELEEKMHEQEKIREQEEKRQEEEKI--------REQEKRQ 379
Query: 357 EKEFDRILEEDKAKKLAEK---DKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQE 413
E+E +E+K ++ EK +E+ E+E + +E M ++ ++QE+ ++ +++E
Sbjct: 380 EQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEE 439
Query: 414 ERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREF 473
+ ++K I E +++ +E+ + +++ ++ K + Q+++ E+EEK R
Sbjct: 440 KIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCE------QEAKMQEQEEKMRRQ 493
Query: 474 EAGVAANKMCLDKVQEVLSTHQVLPQ 499
E + + + + +E + + + Q
Sbjct: 494 EEKIREQEKKIREQEEKIREQEEMMQ 519
Score = 48.5 bits (114), Expect = 1e-05
Identities = 60/293 (20%), Positives = 130/293 (44%), Gaps = 37/293 (12%)
Query: 210 LAKEKREAQEARRQKELME-----NTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNA 264
++KE R+++ A +++L + N +G A T K T +
Sbjct: 39 MSKETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGCHSPEDE 98
Query: 265 Q-IKHENEQDMLKKQKAKQET-------RTILQKALQERIEHIQQEYRDEQDLNMKL--- 313
Q H++++ + ++ +A+ +T +T LQ AL ++Q + +DL +L
Sbjct: 99 QKASHQHQEALRRELEAQVQTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDS 158
Query: 314 ------VQRALQDLQEEADKKKQKREDMIREQ-----KIYHKYLAQRREEEKAQEKEFDR 362
+++AL + + K + E++ +E+ ++Y + +EK + +
Sbjct: 159 WKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKL 218
Query: 363 ILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQ-EKLQREAKEQEERAMEQKH 421
L E + ++ KEL+ + E + L+ + ++LQ + + L +E + + Q
Sbjct: 219 QLVESEKSEIQLNVKELKRKLERAKLLLPQ----QQLQAEADHLGKELQSVSAKLQAQVE 274
Query: 422 INESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFE 474
NE LN +++E R++ QE +++Q +Q+ + E+EEK R E
Sbjct: 275 ENELWNRLNQQQEEKMWRQEEKIQEREEKIQ-----EQEEKIREQEEKMRRQE 322
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 96.3 bits (238), Expect = 6e-20
Identities = 90/420 (21%), Positives = 208/420 (49%), Gaps = 35/420 (8%)
Query: 95 EERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLD 154
+E++ + +E ++ E E E + EK++RMRE+ K+ +++ + + ++ + E+ +
Sbjct: 343 QEKQMREQEQKMRDQEERMWEQD---ERLREKEERMREQEKMWEQEEKMQEEERIRER-E 398
Query: 155 QQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKEK 214
++ RE E +R + +K +E +E +Q+L E++ KLWE++++ +++
Sbjct: 399 KKMREEEETMREQ----EEKMQKQEENMWEQEEKEWQQQRLPEQK--EKLWEQEKMQEQE 452
Query: 215 REAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDM 274
+ E + +K + G ++ + R+ + E+E ++ + E
Sbjct: 453 EKIWE-QEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWE 511
Query: 275 LKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQE---EADKKKQK 331
++ ++E R QK + ++ E +++E + ++ Q +E E +KK ++
Sbjct: 512 QDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMRE 571
Query: 332 REDMIREQ--KIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQL 389
E+M+REQ K+ + R +EEK E+E ++E + K +++K E+E + Q
Sbjct: 572 EEEMMREQEEKMQEQEEKMREQEEKMWEQE--EKMQEQEEKMWEQEEKMWEQEEEDKMQE 629
Query: 390 VDEVMCTRKLQVQEKLQR------EAKEQEERAMEQKHINESLKELNCEEKENFARRQRL 443
+E+M ++ ++QE+ ++ + +EQEE+ EQ+ + +E E++E ++
Sbjct: 630 QEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEK 689
Query: 444 AQEYRKQLQMQ---IAYQQQSQEAEKE-----EKRREFEAGVAANKMCLDKVQEVLSTHQ 495
+E ++++ Q + Q++ ++E E+ RE E + K +K+QE L H+
Sbjct: 690 MREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQK---EKMQERLPEHE 746
Score = 91.7 bits (226), Expect = 1e-18
Identities = 94/431 (21%), Positives = 212/431 (49%), Gaps = 62/431 (14%)
Query: 92 INIEERRNKLRELLALEENEYFTEMQLKKETIEEK----KDRMREKTKLLKEKNEKE-RQ 146
+N++E + KL E F Q++ T++E+ ++ +RE+ K ++++ EK RQ
Sbjct: 208 LNVKELKRKL-------ERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQ 260
Query: 147 DFVAEKLDQQFRERCEELRVELLSIH-QKKVCEERKAQIAFNEELSRQKLVEEQMFSKLW 205
+ + + + RE+ E++R + + Q+K E++ ++ ++L Q+ ++ K+W
Sbjct: 261 EERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMW 320
Query: 206 EEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQ 265
E++ +E+ E R+++ L E K R+ Q ++++E R+ E +
Sbjct: 321 EQEEKMREQEEKMW-RQEERLWEQE-----------KQMREQEQKMRDQEERMWEQDERL 368
Query: 266 IKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEA 325
E E+ M +++K ++ + + +ERI +++ R+E++ E
Sbjct: 369 --REKEERMREQEKMWEQEEKMQE---EERIREREKKMREEEET------------MREQ 411
Query: 326 DKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEA 385
++K QK+E+ + EQ+ ++ QR E+K + E +++ E+++ K+ E+++++R ++E
Sbjct: 412 EEKMQKQEENMWEQE-EKEWQQQRLPEQKEKLWEQEKMQEQEE--KIWEQEEKIRDQEEM 468
Query: 386 RRQLVDEVMCTRKLQVQEKLQREAK---EQEERAMEQKHINESLKELNCEEKENFARRQR 442
Q +K+ QEK++ + EQEE+ +Q+ +E E+ E ++
Sbjct: 469 WGQ-------EKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEE 521
Query: 443 LAQEYRKQLQMQ--IAYQQQSQEAEK-----EEKRREFEAGVAANKMCLDKVQEVLSTHQ 495
+E +K Q + + ++++QE EK EEK RE E K ++ + + +
Sbjct: 522 RMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEE 581
Query: 496 VLPQNIHPMRK 506
+ + MR+
Sbjct: 582 KMQEQEEKMRE 592
Score = 87.8 bits (216), Expect = 2e-17
Identities = 103/399 (25%), Positives = 181/399 (45%), Gaps = 46/399 (11%)
Query: 96 ERRNKLRELLALE-ENEYFTEMQLKKETIE-EKKDRMREKTKLLKEKNEKERQDFVAEKL 153
E K R+ L+LE T +LKK+ E ++K R+ E K + N KE
Sbjct: 162 EELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKE--------- 212
Query: 154 DQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLW-EEDRL-- 210
+ + E + L + + EE Q EEL Q+ + K+W +E+RL
Sbjct: 213 ---LKRKLERAKFLLPQVQTNTLQEEMWRQ---EEELREQEKKIRKQEEKMWRQEERLRE 266
Query: 211 --AKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKH 268
K + + ++ RRQ++ + L Q ++ Q++ L+E+E ++ E +
Sbjct: 267 QEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKK----LREQEEQMQEQEEKMWEQ 322
Query: 269 ENEQDMLKKQKAKQETRTILQKAL---QERIEHIQQEYRDEQDLNMKLVQRALQDLQEEA 325
E + +++ +QE R Q+ QE+ Q+E EQD + R ++ E
Sbjct: 323 EEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERL----REKEERMREQ 378
Query: 326 DKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEA 385
+K ++ E M E++I + R EEE +E +E+K +K E E + EKE
Sbjct: 379 EKMWEQEEKMQEEERIREREKKMREEEETMRE-------QEEKMQKQEENMWE-QEEKEW 430
Query: 386 RRQLVDEVMCTRKLQVQEKLQREAK---EQEERAMEQKHINESLKELNCEEKENFARRQR 442
++Q + E KL QEK+Q + + EQEE+ +Q+ + K++ +EK Q
Sbjct: 431 QQQRLPEQ--KEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQM 488
Query: 443 LAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANK 481
QE + + Q Q + Q+ + E++E+ RE E + K
Sbjct: 489 WEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQK 527
Score = 84.0 bits (206), Expect = 3e-16
Identities = 86/393 (21%), Positives = 203/393 (51%), Gaps = 39/393 (9%)
Query: 94 IEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEK--ERQDFVAE 151
+ E+ ++RE + E E E ++E I E++ +MRE+ + ++E+ EK ++++ + E
Sbjct: 368 LREKEERMREQEKMWEQE---EKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWE 424
Query: 152 KLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFS---KLWEED 208
+ ++++++ + L + + +++ +E++ +I EE R +E+M+ K+W ++
Sbjct: 425 QEEKEWQQ--QRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRD---QEEMWGQEKKMWRQE 479
Query: 209 RLAK------EKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQL-LKEEEARLVES 261
++ + E+ E + QK + R+ + K +R Q + ++E ++ E
Sbjct: 480 KMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREE 539
Query: 262 NNAQIKHENEQDMLKKQKAKQETRTILQKALQER-IEHIQQEYRDEQDLNMKLVQRALQD 320
Q + + D +K + ++ R +K +E + Q+E EQ+ M+ + + +
Sbjct: 540 KKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWE 599
Query: 321 LQE---EADKKKQKREDMIREQKIYHKYLAQR----REEEKAQEKEFDRILEEDKAKKLA 373
+E E ++K ++E+ + EQ+ K Q +EEK QE+E +++ E++ +K+
Sbjct: 600 QEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQE-EKMWEQE--EKMR 656
Query: 374 EKDKELRLEKEARRQLVDEVMCTR--KLQVQEKLQREAKEQEERAMEQKHINESLKELNC 431
E+++++R E+E + Q +E M + K+Q QE+ RE +E++ R E+K + K
Sbjct: 657 EQEEKMR-EQEEKMQGQEEKMREQEEKMQGQEEKMRE-QEEKMRGQEEKMWGQEEKMWGQ 714
Query: 432 EEK----ENFARRQRLAQEYRKQLQMQIAYQQQ 460
EEK E ++ ++ ++++Q ++ ++
Sbjct: 715 EEKMWGQEEMREKEERIRDQKEKMQERLPEHEE 747
Score = 79.0 bits (193), Expect = 1e-14
Identities = 84/344 (24%), Positives = 163/344 (47%), Gaps = 28/344 (8%)
Query: 172 HQKKVCEERKAQIAFNEELSRQK------LVEEQMFSKLWEEDRLAKEKREAQEARRQKE 225
HQ+ + E +AQ L+ QK L Q ++ +E+ L + K A
Sbjct: 79 HQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGNLGESKDLAGRLHHSWH 138
Query: 226 LMENTRLGLNAQIT-SIKAQRQATQLLKEEEARLVES-----NNAQIKHENE--QDMLKK 277
+ L+A T KA R +L KE +A +E N ++K +N Q+ L+
Sbjct: 139 FAGELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLRL 198
Query: 278 QKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKL-VQRALQDLQEEADKKKQKREDMI 336
++++ + K L+ ++E + Q ++ + R ++L+E+ K +++ E M
Sbjct: 199 AESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMW 258
Query: 337 REQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCT 396
R+++ + + RE+E+ ++ R+ E++K +L E++KELR +K+ R Q
Sbjct: 259 RQEERLREQEGKMREQEEKMRRQEKRLREQEK--ELREQEKELREQKKLREQEEQMQEQE 316
Query: 397 RKLQVQEKLQREAKE----QEERAMEQ-KHINESLKELNCEEKENFARRQRLAQ------ 445
K+ QE+ RE +E QEER EQ K + E +++ +E+ + + +RL +
Sbjct: 317 EKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMR 376
Query: 446 EYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQE 489
E K + + Q++ + E+E+K RE E + + + K +E
Sbjct: 377 EQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEE 420
>gi|8922950 meiosis-specific nuclear structural 1 [Homo sapiens]
Length = 495
Score = 94.4 bits (233), Expect = 2e-19
Identities = 97/426 (22%), Positives = 203/426 (47%), Gaps = 36/426 (8%)
Query: 70 NDCKILDSLVRARIKDAVQGFII-NIEERRNKLRELLALEENEYFT-----EMQLKKETI 123
N CK L + ++ ++ N + R + ++ L L +NE F +Q +E
Sbjct: 21 NYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQKAEENK 80
Query: 124 EEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQ 183
K+ +++++ KL E + + + EK+ QQ RE ELR + + +ER AQ
Sbjct: 81 RLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQ 140
Query: 184 IAFNEELSRQKLVEEQMFSK--LWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSI 241
IA + + +++ + +K + E R+ KE+ A++ R + + L +
Sbjct: 141 IAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEK 200
Query: 242 KAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQ 301
K Q QLLKE+ +++ +I E++ + +K + R +++ +E+ ++
Sbjct: 201 KKQEAYEQLLKEK--LMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKK 258
Query: 302 EYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFD 361
+ + ++ N K+++ A Q E D+ + +E+ + ++ + L Q+ EE Q ++ +
Sbjct: 259 KREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNA-LTQKLEEMLRQREDLE 317
Query: 362 RILEE---------DKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQ 412
++ +E K+K E +K+LR +KE ++ +E M ++L +Q AKE+
Sbjct: 318 QVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDF-EEQMALKELVLQ-----AAKEE 371
Query: 413 EE---RAMEQKHINESLKELNCEEKENFARRQRLAQ-EYRKQLQMQIAYQQQSQEAEKEE 468
EE + M K + EL A++QR+ Q E+R+ ++ I ++Q A+K+
Sbjct: 372 EENFRKTMLAKFAEDDRIEL------MNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQR 425
Query: 469 KRREFE 474
+ E++
Sbjct: 426 ELEEWQ 431
Score = 62.4 bits (150), Expect = 1e-09
Identities = 75/342 (21%), Positives = 155/342 (45%), Gaps = 57/342 (16%)
Query: 161 CEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKEKREA--- 217
C++L V+ L K V + + Q+ NE +R V+ + F +L + ++ + EA
Sbjct: 23 CKKLHVQAL----KNVNSQIRNQMVQNENDNR---VQRKQFLRLLQNEQFELDMEEAIQK 75
Query: 218 -QEARRQKELMENTRLGLNAQITSIKAQ-----------RQATQLLKEEEARLVES--NN 263
+E +R KEL L ++ +K + R+ + L+E E +L + N
Sbjct: 76 AEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRELEKKLKAAYMNK 135
Query: 264 AQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQ- 322
+ E+D +K ++ K++ + K + E + I +E +D K + DL+
Sbjct: 136 ERAAQIAEKDAIKYEQMKRDAE--IAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEK 193
Query: 323 --EEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELR 380
EE +KKKQ+ + + ++K+ + ++ I EED+ +K+ +
Sbjct: 194 QLEEQEKKKQEAYEQLLKEKLMIDEIVRK-------------IYEEDQL------EKQQK 234
Query: 381 LEK-EARRQLVDEVMCTRKLQVQEKLQREAKEQEERA------MEQKHINESLKELNCEE 433
LEK A R+ ++E ++ + K +RE E+E R M+Q+ + + ++ E
Sbjct: 235 LEKMNAMRRYIEEFQ--KEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENE 292
Query: 434 KENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEA 475
++ + L Q+ + L+ + +Q QE +EE+ +++
Sbjct: 293 EKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKS 334
Score = 43.5 bits (101), Expect = 5e-04
Identities = 62/278 (22%), Positives = 123/278 (44%), Gaps = 52/278 (18%)
Query: 96 ERRNKLRELLALEENEYFTEMQLKKETIEEKKDRM---------REKTKLLK-EKNEKER 145
E+ N +R + + E + K+E +EE+ ++ RE+ ++ K ++NE++R
Sbjct: 236 EKMNAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKR 295
Query: 146 ---QDFVAEKLDQQFRER--CEELRVELLSIHQ-------------KKVCEERKAQIAFN 187
Q+ + +KL++ R+R E++R EL Q KK+ ++++ + F
Sbjct: 296 LQLQNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFE 355
Query: 188 EELSRQKLV------EEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSI 241
E+++ ++LV EE+ F K ++ E A++Q+ R + I
Sbjct: 356 EQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEER 415
Query: 242 KAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQ 301
+ Q A + + EE +L + I E++ LK K E T L L + +
Sbjct: 416 RQQFLADKQRELEEWQLQQRRQGFINAIIEEERLKLLK---EHATNLLGYLPKGV----- 467
Query: 302 EYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQ 339
++ E D+++ L EE K Q+R ++ E+
Sbjct: 468 -FKKEDDIDL---------LGEEFRKVYQQRSEICEEK 495
Score = 43.1 bits (100), Expect = 6e-04
Identities = 45/190 (23%), Positives = 83/190 (43%), Gaps = 16/190 (8%)
Query: 319 QDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKE 378
Q L +E KK + + + Q + + Q K+F R+L+ ++ E D E
Sbjct: 15 QKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQ----FELDME 70
Query: 379 LRLEKEARRQLVDEVMCTR--KLQVQ-EKLQREAKEQEERAMEQKHINESLKELNCEEKE 435
++K + + E+ + KL ++ KL+ E+ + E+ + + + L+EL + K
Sbjct: 71 EAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRELEKKLKA 130
Query: 436 NFARRQRLAQEYRKQLQMQIAYQQQSQEAE------KEEKRREFEAGVAANKMCLDKVQE 489
+ ++R AQ K I Y+Q ++AE +E KR E A +K K Q
Sbjct: 131 AYMNKERAAQIAEKD---AIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQY 187
Query: 490 VLSTHQVLPQ 499
L + L +
Sbjct: 188 YLDLEKQLEE 197
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 91.3 bits (225), Expect = 2e-18
Identities = 77/314 (24%), Positives = 156/314 (49%), Gaps = 48/314 (15%)
Query: 199 QMFSKLWEEDRLA--KEKREAQEARRQK------ELMENTRLGLNAQITSIKAQRQATQL 250
+M K E RL + K EA++ RRQK +E +L ++ + R+ +
Sbjct: 527 RMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQ 586
Query: 251 LKEEEARLVESNNAQIKHENE---QDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQ 307
+KEE+ + +E AQI + E ++ L ++KAK+ KA +++E ++ + E+
Sbjct: 587 MKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKK-------KAAAKKMEEVEARRKQEE 639
Query: 308 DLN-MKLVQRALQDLQEEADKKKQKREDMIREQKIYH-KYLAQRREEEKAQEKEFDRILE 365
+ ++ +Q+ ++ + + +K+K E+ R +K K LA++RE+E+ +++ ++
Sbjct: 640 EARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERR 699
Query: 366 EDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINES 425
E + ++ +++E +L ++ RR+ + + R+LQ +EK R KEQ +R +E+K E
Sbjct: 700 EQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKE- 758
Query: 426 LKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLD 485
+QRLA+ +QLQ E+E+K +E A + +D
Sbjct: 759 -------------EQQRLAE---RQLQ-----------EEQEKKAKEAAGASKALNVTVD 791
Query: 486 KVQEVLSTHQVLPQ 499
+++Q+ PQ
Sbjct: 792 VQSPACTSYQMTPQ 805
Score = 83.6 bits (205), Expect = 4e-16
Identities = 82/319 (25%), Positives = 158/319 (49%), Gaps = 74/319 (23%)
Query: 95 EERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLD 154
E+ R +L L EE E QL+++ +EE K R E+ KL +E+ ++
Sbjct: 532 EKERQRLENLRRKEEAE-----QLRRQKVEEDKRRRLEEVKLKREERLRKVL-------- 578
Query: 155 QQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKEK 214
Q RER E+++ EE+K QI EQ F+++ E+ AKE+
Sbjct: 579 -QARERVEQMK------------EEKKKQI-------------EQKFAQIDEKTEKAKEE 612
Query: 215 REAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDM 274
R A+E ++K + ++ ++A+R+ +EEEAR + + + Q++
Sbjct: 613 RLAEEKAKKKAAAK--------KMEEVEARRK-----QEEEARRLRWLQQEEEERRHQEL 659
Query: 275 LKKQKAKQETRTILQKALQER--IEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKR 332
L+K+K +++ R L+KA + + E +QE R+ Q+ +E+ +++++R
Sbjct: 660 LQKKKEEEQER--LRKAAEAKRLAEQREQERRE-------------QERREQERREQERR 704
Query: 333 EDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDE 392
E REQ+ +RRE+E+ Q + + E +KA +L ++ + LE++ +++ E
Sbjct: 705 EQERREQERQLAEQERRREQERLQAER--ELQEREKALRLQKEQLQRELEEKKKKE---E 759
Query: 393 VMCTRKLQVQEKLQREAKE 411
+ Q+QE+ +++AKE
Sbjct: 760 QQRLAERQLQEEQEKKAKE 778
Score = 65.1 bits (157), Expect = 1e-10
Identities = 74/318 (23%), Positives = 146/318 (45%), Gaps = 26/318 (8%)
Query: 191 SRQKLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQL 250
+R+K +Q S+L EE L E+ + ++ +++ + QR +
Sbjct: 447 ARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLM 506
Query: 251 LKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLN 310
R V + IK M K+K +Q + +K E++
Sbjct: 507 TPTSAPRSVMKSF--IKRNTPLRMDPKEKERQRLENLRRKEEAEQLRR------------ 552
Query: 311 MKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQ-EKEFDRILEE-DK 368
Q+ +D + ++ K KRE+ +R+ + + Q +EE+K Q E++F +I E+ +K
Sbjct: 553 ----QKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEK 608
Query: 369 AKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKE 428
AK+ E+ E + +K+A + ++EV RK + + + R +++EE Q+ + + KE
Sbjct: 609 AKE--ERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKK-KE 665
Query: 429 LNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEK-EEKRREFEAGVAANKMCLDKV 487
E A +RLA++ ++ + Q +Q+ +E E+ E++RRE E +A + +
Sbjct: 666 EEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQER--RRE 723
Query: 488 QEVLSTHQVLPQNIHPMR 505
QE L + L + +R
Sbjct: 724 QERLQAERELQEREKALR 741
Score = 52.8 bits (125), Expect = 8e-07
Identities = 70/315 (22%), Positives = 135/315 (42%), Gaps = 54/315 (17%)
Query: 8 TVQREVKGPTP--------KVVIVRSKPPKGQGAE---HHLERIRRSHQKHNAILASIKS 56
TVQR TP K I R+ P + E LE +RR + ++
Sbjct: 498 TVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEE 557
Query: 57 SERDRLKAEWDQHNDC--KILDSLVRARI-----KDAVQGFIINIEERRNKLRELLALEE 109
+R RL+ + + K+L + R K ++ I+E+ K +E EE
Sbjct: 558 DKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEE 617
Query: 110 NEYFTEMQLKKETIEEKKDRMREKTKL--LKEKNEKERQDFVAEKLDQQFRERCEELRVE 167
K E +E ++ + E +L L+++ E+ R + +K ++ +ER +
Sbjct: 618 KAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRK---- 673
Query: 168 LLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKEKREAQEARRQKELM 227
+ K++ E+R+ + E +++ +E+ E++R +E++ A++ RR+
Sbjct: 674 --AAEAKRLAEQREQERREQERREQERREQERR-----EQERREQERQLAEQERRR---- 722
Query: 228 ENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTI 287
E RL QA + L+E E L +++ E Q L+++K K+E + +
Sbjct: 723 EQERL-------------QAERELQEREKAL------RLQKEQLQRELEEKKKKEEQQRL 763
Query: 288 LQKALQERIEHIQQE 302
++ LQE E +E
Sbjct: 764 AERQLQEEQEKKAKE 778
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 90.9 bits (224), Expect = 3e-18
Identities = 133/572 (23%), Positives = 253/572 (44%), Gaps = 112/572 (19%)
Query: 10 QREVKGPTPKVVIVRSKPPKGQGAEHHLERIRRSHQKHNAILASIKSSERDRLKAEWDQH 69
+ E++ +++ V+ K K +G LE + R HQ+ L K+ ++L+AE +
Sbjct: 851 EEELQAKDEELLKVKEKQTKVEG---ELEEMERKHQQ----LLEEKNILAEQLQAETELF 903
Query: 70 NDCKILDSLVRARIKDAVQGFIINIEER-----------RNKLRELLA--------LEEN 110
+ + + + + A+ K ++ + ++E R +N+ +++ A L+E
Sbjct: 904 AEAEEMRARLAAK-KQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEE 962
Query: 111 EYFTE-MQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRERCEELRVELL 169
E + +QL+K T E K +M E+ LL+++N K F+ EK + +R E +L
Sbjct: 963 EGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSK----FIKEK--KLMEDRIAECSSQLA 1016
Query: 170 SIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMEN 229
EE KA + L++ + +E M S L E+RL KE++ QE + K ++
Sbjct: 1017 E-------EEEKA-----KNLAKIRNKQEVMISDL--EERLKKEEKTRQELEKAKRKLDG 1062
Query: 230 TRLGLNAQITSIKAQ--RQATQLLKEEE----------------------ARLVESNNAQ 265
L QI ++AQ QL K+EE R +++ A+
Sbjct: 1063 ETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAE 1122
Query: 266 IKHENEQDMLKKQKAKQETRTILQ--KALQERIEHIQQEYRDEQDLNMKLVQRALQDLQE 323
++ + E + + KA+++ R + + +AL+ +E +Q+L K Q + +L++
Sbjct: 1123 LQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQE-VAELKK 1181
Query: 324 EADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEK 383
+++ + E I++ + H + E+ Q K F LE++K + L +KEL E
Sbjct: 1182 ALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNK-QGLETDNKELACEV 1240
Query: 384 EARRQLVDEVMCTRK---LQVQE---------KLQREAKEQEERAMEQKHINESLKELNC 431
+ +Q+ E RK QVQE +L+ E E+ + + +L E
Sbjct: 1241 KVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAE 1300
Query: 432 EEKENFAR------------RQRLAQEYRKQLQMQIAYQQ--------QSQEAEKEEKRR 471
++ FA+ ++ L +E R++L + +Q Q Q+ E+EE R+
Sbjct: 1301 KKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARK 1360
Query: 472 EFEAGVAANKMCL----DKVQEVLSTHQVLPQ 499
E V A + L KV + L T + L +
Sbjct: 1361 NLEKQVLALQSQLADTKKKVDDDLGTIESLEE 1392
Score = 74.7 bits (182), Expect = 2e-13
Identities = 94/401 (23%), Positives = 195/401 (48%), Gaps = 51/401 (12%)
Query: 115 EMQLKKET-IEEKKDRMREKTKLLKEKNEKERQ------DFVAEKLDQ--QFRERCEELR 165
E++ K+E + E K + E+TK + + + RQ + ++E+L+Q +F+ E+ +
Sbjct: 1167 ELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNK 1226
Query: 166 VELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQ---MFSKLWEEDRLAKEKREAQEARR 222
L + +++ CE + Q E ++K ++ Q + +K+ E DRL E E + ++
Sbjct: 1227 QGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAE-KASKL 1285
Query: 223 QKEL---------MENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKH--ENE 271
Q EL E + S+++Q Q TQ L +EE R + +++I+ E +
Sbjct: 1286 QNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEK 1345
Query: 272 QDMLKKQKAKQETRTILQK---ALQERIEHIQQEYRDE-------QDLNMKLVQRA---L 318
+ ++Q+ ++E R L+K ALQ ++ +++ D+ ++ KL++ A
Sbjct: 1346 NSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALS 1405
Query: 319 QDLQEEA------DKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKL 372
Q L+E+A +K K + + + + + + Q + ++K+FD++L E+K+
Sbjct: 1406 QRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISA 1465
Query: 373 AEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCE 432
++ R E EAR + + R L +E L EAKE+ ER + K + +++L
Sbjct: 1466 RYAEERDRAEAEAREKETKALSLARAL--EEAL--EAKEEFER--QNKQLRADMEDL-MS 1518
Query: 433 EKENFARRQRLAQEYRKQLQMQI-AYQQQSQEAEKEEKRRE 472
K++ + ++ ++ L+ Q+ + Q +E E E + E
Sbjct: 1519 SKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATE 1559
Score = 69.7 bits (169), Expect = 6e-12
Identities = 111/510 (21%), Positives = 223/510 (43%), Gaps = 96/510 (18%)
Query: 64 AEWDQHNDCKILDSLVRARIKDAVQGFIIN--IEERRNKLRELLALEEN----------- 110
A ++ D KI D ++ + +G++ +++ +L L L+ N
Sbjct: 776 AHLEEERDLKITDIIIF--FQAVCRGYLARKAFAKKQQQLSALKVLQRNCAAYLKLRHWQ 833
Query: 111 --EYFTEMQLKKETIEEKKDRMREKTKLLKEKNEK------------------ERQDFVA 150
FT+++ + ++++ + +LLK K ++ E ++ +A
Sbjct: 834 WWRVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILA 893
Query: 151 EKL--DQQFRERCEELRVELLS-----------IHQKKVCEERKAQIAFNEELSRQKLV- 196
E+L + + EE+R L + + + EE + QI NE+ Q +
Sbjct: 894 EQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQ 953
Query: 197 --EEQMFSKLWEEDRLAKEK--REAQEARRQKELM----ENTRLGLNAQITSIKAQRQAT 248
EEQ+ + +L EK EA+ + ++E++ +N++ ++ + ++
Sbjct: 954 DLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSS 1013
Query: 249 QLLKEEEARLVESNNAQIKHENE---QDMLKKQKAKQETRTILQKALQERIEHIQQEYRD 305
QL +EEE N A+I+++ E D+ ++ K +++TR L+KA ++ + E D
Sbjct: 1014 QLAEEEEK---AKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRK----LDGETTD 1066
Query: 306 EQDLNMKLVQRALQDLQEEADKKKQKREDMIR--EQKIYHKYLAQRREEE-KAQEKEFDR 362
QD +L Q + +L+ + KK+++ + + + + HK A + E +AQ E
Sbjct: 1067 LQDQIAEL-QAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQE 1125
Query: 363 ILEEDKA-KKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKH 421
E +KA + AEK K R L +E+ K ++++ L A +QE R ++
Sbjct: 1126 DFESEKASRNKAEKQK---------RDLSEELEAL-KTELEDTLDTTAAQQELRTKREQE 1175
Query: 422 INESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANK 481
+ E K L E K + A+ Q + Q + L+ + +E+ E+ + F+A + NK
Sbjct: 1176 VAELKKALEEETKNHEAQIQDMRQRHATALE---------ELSEQLEQAKRFKANLEKNK 1226
Query: 482 MCLDK-----VQEVLSTHQVLPQNIHPMRK 506
L+ EV QV ++ H +K
Sbjct: 1227 QGLETDNKELACEVKVLQQVKAESEHKRKK 1256
Score = 67.8 bits (164), Expect = 2e-11
Identities = 109/481 (22%), Positives = 203/481 (42%), Gaps = 81/481 (16%)
Query: 40 IRRSHQKHNAILASIKS------SERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIIN 93
+ + +K + +LA KS ERDR +AE + + K L SL RA
Sbjct: 1446 LEKKQKKFDQLLAEEKSISARYAEERDRAEAE-AREKETKAL-SLARA------------ 1491
Query: 94 IEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKL 153
+EE ALE E F K+ + +D M K + K +E E+ E+
Sbjct: 1492 LEE---------ALEAKEEFERQN--KQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQ 1540
Query: 154 DQQFRERCEELRVELLSIHQKKVCEERKAQIA---FNEELSRQKLVEEQMFSKLWEEDRL 210
++ R + EEL EL + K+ E Q F +L + E+ L ++ R
Sbjct: 1541 VEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVR- 1599
Query: 211 AKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIK-HE 269
+ + E ++ R+Q+ L ++ + + ++AQ +A ++E + + AQ+K ++
Sbjct: 1600 -ELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQ 1658
Query: 270 NE-------------QDMLKKQKAKQETRTILQK----ALQERIEHIQQEYRDE---QDL 309
E Q ++K K ILQ A ER ++ RDE +
Sbjct: 1659 RELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEIT 1718
Query: 310 NMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQR----------------REEE 353
N + AL D + + + + E+ + E++ + L R E
Sbjct: 1719 NSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERS 1778
Query: 354 KAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQE 413
AQ+ + R E + K+L K +EL +++ + + + Q++E+L++EAKE+
Sbjct: 1779 AAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERA 1838
Query: 414 ERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQIA----YQQQSQEAEKEEK 469
+ + LKE+ + ++ +R A +Y++Q++ A ++Q +EAE+E
Sbjct: 1839 AANKLVRRTEKKLKEIFMQVED----ERRHADQYKEQMEKANARMKQLKRQLEEAEEEAT 1894
Query: 470 R 470
R
Sbjct: 1895 R 1895
Score = 65.9 bits (159), Expect = 9e-11
Identities = 90/430 (20%), Positives = 186/430 (43%), Gaps = 71/430 (16%)
Query: 93 NIEERRNKLRELLALEEN---EYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFV 149
N+E+++ K +LLA E++ Y E + EK+ + + L+E E +
Sbjct: 1445 NLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAK----- 1499
Query: 150 AEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDR 209
++F + ++LR ++ + K +++ K V E SK E +
Sbjct: 1500 -----EEFERQNKQLRADMEDLMSSK------------DDVG--KNVHELEKSKRALEQQ 1540
Query: 210 LAKEKREAQEARRQKELMENTRLGLNAQITSIKAQ----RQATQLLKEEEARLVESNNAQ 265
+ + + + +E + + E+ +L L + ++KAQ Q EE+ RL+ +
Sbjct: 1541 VEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRE 1600
Query: 266 IKHENEQDMLKKQK----AKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDL 321
++ E E + +KQ+ A ++ I K L+ +IE + RDE ++ +Q ++D
Sbjct: 1601 LEAELEDE--RKQRALAVASKKKMEIDLKDLEAQIE-AANKARDEVIKQLRKLQAQMKDY 1657
Query: 322 QEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDK---- 377
Q E ++ + R+++ + K K L E ++E + ++A++ AE+++
Sbjct: 1658 QRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEE---LASSERARRHAEQERDELA 1714
Query: 378 -ELRLEKEARRQLVDEV--MCTRKLQVQEKLQREAKEQE--------------------- 413
E+ + L+DE + R Q++E+L+ E E
Sbjct: 1715 DEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELA 1774
Query: 414 -ERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRRE 472
ER+ QK N + ++L + KE A+ Q L + + + I+ + +E+ +E
Sbjct: 1775 AERSAAQKSDN-ARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQE 1833
Query: 473 FEAGVAANKM 482
+ AANK+
Sbjct: 1834 AKERAAANKL 1843
Score = 65.1 bits (157), Expect = 1e-10
Identities = 85/404 (21%), Positives = 179/404 (44%), Gaps = 55/404 (13%)
Query: 159 ERCEELRVELLSIHQKKVCEERKAQIAF---NEELSRQKLVEEQMFSKL----WEEDRL- 210
E +L++ + I + VC A+ AF ++LS K+++ + L W+ R+
Sbjct: 779 EEERDLKITDIIIFFQAVCRGYLARKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRVF 838
Query: 211 AKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHEN 270
K K Q R+++EL L + K + + ++ ++ + L E N + +
Sbjct: 839 TKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQA 898
Query: 271 EQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNM------KLVQRALQDLQEE 324
E ++ + + + ++ L+E + ++ +E++ N K +Q +QDL+E+
Sbjct: 899 ETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQ 958
Query: 325 ADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDK--AKKLAEKDKELRLE 382
D+++ R+ + E+ + + EE E + + ++E K ++AE +L E
Sbjct: 959 LDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEE 1018
Query: 383 KEARRQLV-----DEVMCT---RKLQVQEKLQREAKE------------QEERAMEQKHI 422
+E + L EVM + +L+ +EK ++E ++ Q++ A Q I
Sbjct: 1019 EEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQI 1078
Query: 423 NESLKELNCEEKE---------NFARRQRLAQEYRKQLQMQIAYQQQSQEAEK------E 467
+E +L +E+E + + A + ++LQ QIA Q+ E+EK E
Sbjct: 1079 DELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAE 1138
Query: 468 EKRREFEAGVAANKMCLDKVQEVLSTHQVL----PQNIHPMRKA 507
+++R+ + A K L+ + + Q L Q + ++KA
Sbjct: 1139 KQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKA 1182
Score = 48.1 bits (113), Expect = 2e-05
Identities = 84/409 (20%), Positives = 175/409 (42%), Gaps = 64/409 (15%)
Query: 22 IVRSKPPKGQGAEHHLERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRA 81
++ SK G+ H LE+ +R+ ++ + + D L+A D ++ ++A
Sbjct: 1516 LMSSKDDVGKNV-HELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKA 1574
Query: 82 RIKDAVQGFIINIEERRNKL----RELLALEENEY----------------FTEMQLKKE 121
+ + +Q EE++ L REL A E+E +++ + E
Sbjct: 1575 QFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIE 1634
Query: 122 TIEEKKDRMREKTKLLK----------EKNEKERQDFVAEKLDQQFRERCEELRVELLSI 171
+ +D + ++ + L+ E+ R + A+ + + ++ + L E+L +
Sbjct: 1635 AANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESE--KKLKSLEAEILQL 1692
Query: 172 HQKKVCEERKAQIAFNEELSRQKLVEEQMFS----------KLWEEDRLAKEKREAQEAR 221
++ ER + A E R +L +E S K E R+A+ + E +E +
Sbjct: 1693 QEELASSERARRHA---EQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQ 1749
Query: 222 RQKELMEN----TRLGLNAQITSIKAQRQATQLLKEEEARL-VESNNAQIKHE-NEQDML 275
EL+ + T L ++ + A+R A Q K + AR +E N ++K + E +
Sbjct: 1750 SNMELLNDRFRKTTLQVDTLNAELAAERSAAQ--KSDNARQQLERQNKELKAKLQELEGA 1807
Query: 276 KKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDM 335
K K K T + L+ + + E ++QE ++ N KLV+R +KK ++
Sbjct: 1808 VKSKFKA-TISALEAKIGQLEEQLEQEAKERAAAN-KLVRRT--------EKKLKEIFMQ 1857
Query: 336 IREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKE 384
+ +++ + ++ E+ A+ K+ R LEE + + +L++E
Sbjct: 1858 VEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRE 1906
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 90.9 bits (224), Expect = 3e-18
Identities = 120/517 (23%), Positives = 237/517 (45%), Gaps = 51/517 (9%)
Query: 2 YSQRFGTVQREVKGPTPKVVIVRSKPPKGQGAEHHLERIRRSHQKHNAILASIKSSERDR 61
++++ ++R ++ V +R + + + ER R ++ +K++E R
Sbjct: 1585 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW-QLKANEALR 1643
Query: 62 LKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNKLRELLA----LEENEYFTEMQ 117
L+ + ++ K L + K+ + RR K E L E E + Q
Sbjct: 1644 LRLQAEEVAQQKSLAQAEAEKQKEEAE----REARRRGKAEEQAVRQRELAEQELEKQRQ 1699
Query: 118 LKKETIEEKKDRMREKTKLLKEKNEKERQ-DFVAEKLDQQFRERC------EELRVELLS 170
L + T +++ +E +L E + E+Q + E+L + RE +EL EL
Sbjct: 1700 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1759
Query: 171 IH-QKKVCEERKAQIA----FNEELSRQKL-VEEQMFSKLWEEDRLAKEKREAQEARRQK 224
+ + +V KA+ E S+Q+L E F +L EE A+ + A+EA+RQ+
Sbjct: 1760 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE--AARLRALAEEAKRQR 1817
Query: 225 ELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQET 284
+L E + + + +A ++L E+ A + E+ ++K E E + +K+ +
Sbjct: 1818 QLAEED---------AARQRAEAERVLAEKLAAIGEAT--RLKTEAEIALKEKEAENERL 1866
Query: 285 RTILQKALQERIEHIQQEYRDEQDLNMKLVQ-RALQDLQEEADKKKQKREDMIREQK-IY 342
R + + +R +Q + + D+ +L Q R D E +++K ED +R+++ +
Sbjct: 1867 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD--SELERQKGLVEDTLRQRRQVE 1924
Query: 343 HKYLAQRREEEKAQEKEFDRILEEDKAKKLAE----KDKELRLEKEARRQLVDEVMCTRK 398
+ LA + EKA + + LE + + AE ++ LE +RQL E R+
Sbjct: 1925 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE-RRR 1983
Query: 399 LQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQM-QIAY 457
+ +E++Q+ +EE A ++K E ++ L + +E R+R QE +QLQ+ Q A
Sbjct: 1984 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2043
Query: 458 QQQSQEAEK------EEKRREFEAGVAANKMCLDKVQ 488
Q++ Q EK ++K +E + + + LD+++
Sbjct: 2044 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2080
Score = 85.9 bits (211), Expect = 8e-17
Identities = 121/487 (24%), Positives = 226/487 (46%), Gaps = 49/487 (10%)
Query: 34 EHHLERIRRSHQKHNAILASIKSSERDRLKAEWD----QHNDCKILDSLVRARIKDAVQG 89
E L + R+ ++ A+ AS + + + + E + + N L S +A ++ A Q
Sbjct: 1914 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1973
Query: 90 FIINIEERRNK-----LRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKE 144
+ EERR + +++ LA EE E + + E +E K ++ E+ + L+E+ E+E
Sbjct: 1974 QLAAEEERRRREAEERVQKSLAAEE-EAARQRKAALEEVERLKAKV-EEARRLRERAEQE 2031
Query: 145 --RQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFS 202
RQ +A++ Q+ R + EE + ++ QK+ +E + + + + Q E +
Sbjct: 2032 SARQLQLAQEAAQK-RLQAEE-KAHAFAVQQKE--QELQQTLQQEQSVLDQLRGEAEAAR 2087
Query: 203 KLWEEDRLAK--EKREAQEARRQKELMENTRLGLNAQITS-IKAQRQATQLLKEEE---A 256
+ EE A+ +REA ++RRQ E E + Q + +AQ A +L KE E A
Sbjct: 2088 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2147
Query: 257 RLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQR 316
R ++ A ++ + D ++ K +T+ QKA E+ + +E D L+
Sbjct: 2148 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2207
Query: 317 ALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKD 376
LQ L+ EA + ++R + E L R + + K RI E++A L +KD
Sbjct: 2208 ELQRLKAEATEAARQRSQVEEE-------LFSVRVQMEELSKLKARIEAENRALILRDKD 2260
Query: 377 KELRL---EKEARRQLVDEVM-CTRKLQVQEKLQREAKEQ--EERAMEQKHINESLK--- 427
R E E +Q+ +E + Q +L++ A+E ++RA+ +K + E ++
Sbjct: 2261 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2320
Query: 428 ---------ELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQS-QEAEKEEKRREFEAGV 477
EL ++KE + R QE ++Q+ Q+A + Q Q + E++R+ E
Sbjct: 2321 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2380
Query: 478 AANKMCL 484
A ++ L
Sbjct: 2381 EAERLKL 2387
Score = 85.5 bits (210), Expect = 1e-16
Identities = 110/422 (26%), Positives = 192/422 (45%), Gaps = 53/422 (12%)
Query: 96 ERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQ 155
E +L E EE E E+ E EK+ ++ E K + E+E A++L Q
Sbjct: 1345 EEEERLAEQQRAEERERLAEV----EAALEKQRQLAEAHAQAKAQAERE-----AKELQQ 1395
Query: 156 QFRE---RCEELRVELLSIHQKKVCEERKAQIAFNEEL-----SRQKLVEEQMFSKLWEE 207
+ +E R EE V+ + QK+ +E Q+ + E +RQ E+ ++ EE
Sbjct: 1396 RMQEEVVRREEAAVD--AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1453
Query: 208 DRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIK 267
R+ + + EA E RQ+ E L A+ +AQ++ Q E R V+ + +Q K
Sbjct: 1454 IRVVRLQLEATE--RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ-DESQRK 1510
Query: 268 HENEQDMLKKQKAKQETRTILQKALQE------RIEHIQQEYRDEQDLNMKLVQRALQDL 321
+ E ++ + KA+ E Q+ALQ + E ++ R + + VQ AL+
Sbjct: 1511 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1570
Query: 322 QEEADKKKQ--------KREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLA 373
Q A+ + Q K + R + H +AQ REE E+ + E ++A++ A
Sbjct: 1571 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE---AERRAQQQAEAERAREEA 1627
Query: 374 EKDKE---LRLEKEARRQLVDEVMCTRKLQVQ-------EKLQREAKEQ---EERAMEQK 420
E++ E L+ + R +L E + +K Q E+ +REA+ + EE+A+ Q+
Sbjct: 1628 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1687
Query: 421 HINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAY-QQQSQEAEKEEKRREFEAGVAA 479
+ E E + E A+++ A++ +L+ + +QQ Q E+E R + EA A
Sbjct: 1688 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1747
Query: 480 NK 481
K
Sbjct: 1748 QK 1749
Score = 79.7 bits (195), Expect = 6e-15
Identities = 115/542 (21%), Positives = 227/542 (41%), Gaps = 98/542 (18%)
Query: 33 AEHHLERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFII 92
A+ ER+RR Q + + R+KAE + + + R A++ +
Sbjct: 1492 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE--------KQRALQALEELRL 1543
Query: 93 NIEERRNKLRELLALEENEYFTEMQLKKET--------IEEKKDRMREKTKLLKEKNEKE 144
EE +LR+ E E ++Q+ ET ++ K+ EKT L+ ++E
Sbjct: 1544 QAEEAERRLRQA----EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1599
Query: 145 -------RQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVE 197
R++ Q ER E L Q K E + ++ E ++ L +
Sbjct: 1600 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1659
Query: 198 EQMFSKLWEEDRLAKEKREA------------QEARRQKELMENT---RLGLNAQITSIK 242
+ + E +R A+ + +A QE +Q++L E T RL ++ ++
Sbjct: 1660 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1719
Query: 243 AQ----RQATQLLKEEEARL-------------VESNNAQIKHENEQDMLKKQKAKQETR 285
A+ Q QLL+EE ARL +E+ A+++ E E + K +A++E+R
Sbjct: 1720 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1779
Query: 286 TILQKALQE----------------RIEHIQQEYRDEQDLNMKLVQRALQDLQE------ 323
+ +K+ Q R+ + +E + ++ L + R + +
Sbjct: 1780 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1839
Query: 324 ----EADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKA---KKLAEKD 376
EA + K + E ++E++ ++ L + E+E Q + + + KA ++LA+
Sbjct: 1840 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1899
Query: 377 KELRLEKEARRQLVDEVMCTRKLQVQEKL-------QREAKEQEERAMEQKHINESLKEL 429
K E E ++ LV++ + R+ QV+E++ ++ A + E +E I + ++
Sbjct: 1900 KASDSELERQKGLVEDTLRQRR-QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 1958
Query: 430 --NCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKV 487
+ E+ E A RQR ++ + + + Q A +EE R+ +A + + KV
Sbjct: 1959 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2018
Query: 488 QE 489
+E
Sbjct: 2019 EE 2020
Score = 79.0 bits (193), Expect = 1e-14
Identities = 88/386 (22%), Positives = 183/386 (47%), Gaps = 21/386 (5%)
Query: 92 INIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKN-EKERQDFVA 150
I ++E+ + L L E+E F +L+++ + K D +L K + E ERQ +
Sbjct: 1854 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1913
Query: 151 EKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSR-QKLVEEQMFSKLWEEDR 209
E +Q R+ EE+ + L + +K + + ++ EL R + E+ + SK E
Sbjct: 1914 EDTLRQRRQVEEEI-LALKASFEKAAAGKAELEL----ELGRIRSNAEDTLRSKEQAELE 1968
Query: 210 LAKEKR-EAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKH 268
A++++ A+E RR++E E + L A+ + + ++ A + ++ +A++ E+ +++
Sbjct: 1969 AARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR--RLRE 2026
Query: 269 ENEQDMLKKQKAKQETRTILQKALQ-ERIEHIQQEYRDEQDLNMKLVQR--ALQDLQEEA 325
EQ+ ++ + QE QK LQ E H + EQ+L L Q L L+ EA
Sbjct: 2027 RAEQESARQLQLAQEAA---QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2083
Query: 326 DKKKQKREDMIREQKIYHKYLAQRR----EEEKAQEKEFDRILEEDKAKKLAEKDKELRL 381
+ ++ E+ + + AQ R E E+ ++ ++ +A+ AEK ++
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2143
Query: 382 EKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQ 441
++ ARR ++ +K ++++ K E+ ++ + + L L + +E ++
Sbjct: 2144 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2203
Query: 442 RLAQE-YRKQLQMQIAYQQQSQEAEK 466
L +E R + + A +Q+SQ E+
Sbjct: 2204 LLDEELQRLKAEATEAARQRSQVEEE 2229
Score = 72.8 bits (177), Expect = 7e-13
Identities = 65/280 (23%), Positives = 143/280 (51%), Gaps = 29/280 (10%)
Query: 194 KLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKE 253
K + E + ++ EE+RLA+++R A+E R E+ +++ QRQ + +
Sbjct: 1335 KFISETL-RRMEEEERLAEQQR-AEERERLAEVE-----------AALEKQRQLAEAHAQ 1381
Query: 254 EEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKL 313
+A+ E +++ +++++++++A + + ++++QE ++ ++Q E ++ K
Sbjct: 1382 AKAQ-AEREAKELQQRMQEEVVRREEAAVDAQQ-QKRSIQEELQQLRQS--SEAEIQAKA 1437
Query: 314 VQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLA 373
Q E A++ + + E+ IR ++ + ++R + + + EE +A+K
Sbjct: 1438 RQA------EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1491
Query: 374 EKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEE 433
+++ RL RRQ+ DE RK Q + +L K + E A E++ ++L+EL +
Sbjct: 1492 AQEEAERL----RRQVQDESQ--RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1545
Query: 434 KENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREF 473
+E R ++ E +Q+Q+ + Q+S EAE + KR F
Sbjct: 1546 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1585
Score = 71.6 bits (174), Expect = 2e-12
Identities = 112/526 (21%), Positives = 218/526 (41%), Gaps = 92/526 (17%)
Query: 41 RRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNK 100
+RS + ++ E +LKA + N IL R KD Q F+ E+ +
Sbjct: 2222 QRSQVEEELFSVRVQMEELSKLKARIEAENRALIL------RDKDNTQRFLQEEAEKMKQ 2275
Query: 101 LRE--------------LLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQ 146
+ E L L E + + L ++ ++EK ++E T+L E ++Q
Sbjct: 2276 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2335
Query: 147 DFVAEKLDQQFRERCEELRVELLSI---HQKKVCEERKAQIAFNEELSRQKL-VEEQMFS 202
+A++ ++ +E E++ +L Q+ + ER+ Q+ + E R KL V E +
Sbjct: 2336 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2395
Query: 203 KLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQIT---SIKAQRQAT----------- 248
+ E+ + +++A+E E + T L ++T +++ QRQ +
Sbjct: 2396 QARAEEDAQRFRKQAEEIG---EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2452
Query: 249 -QLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQ------- 300
+L +E+E E+ Q+K E E +++++ QET+ + Q L E+ +Q
Sbjct: 2453 AELEREKEKLQQEAKLLQLKSE-EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2511
Query: 301 ----------------QEYRDEQDLNMKLVQRALQDL---QEEADKKKQKREDMIR-EQK 340
Q+ R+EQ + +++ Q L EEA +++ + E+ +R +Q+
Sbjct: 2512 EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE 2571
Query: 341 IYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKL- 399
+ QRR++E+ +E R+ E+ +L E+ L + +V T+ L
Sbjct: 2572 ELQQLEQQRRQQEELLAEENQRLREQ---LQLLEEQHRAAL-AHSEEVTASQVAATKTLP 2627
Query: 400 QVQEKLQREAKEQEER----AMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQI 455
++ L A E E + +K + L+E E QRLAQ
Sbjct: 2628 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL---QRLAQ---------- 2674
Query: 456 AYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEVLSTHQVLPQNI 501
+ + A +E+ R + + + L E LS + L + +
Sbjct: 2675 GHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQL 2720
Score = 48.1 bits (113), Expect = 2e-05
Identities = 80/337 (23%), Positives = 143/337 (42%), Gaps = 63/337 (18%)
Query: 149 VAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEED 208
V E+L Q+ ER ++ VE ++ E +A +A Q V ++ +L +
Sbjct: 1159 VGERLQQRHGER--DVEVERWRERVAQLLERWQAVLA-------QTDVRQRELEQLGRQL 1209
Query: 209 RLAKEKREA-----QEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNN 263
R +E + Q+ARR++E ++ L A +++ Q + Q L EE
Sbjct: 1210 RYYRESADPLGAWLQDARRRQEQIQAMPL---ADSQAVREQLRQEQALLEE--------- 1257
Query: 264 AQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQE 323
I+ E+ ++ AKQ I LQ Q E K+ + +QE
Sbjct: 1258 --IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1315
Query: 324 EADKKKQKREDMIREQKIYHKYLAQ--RREEEKAQEKEFDRILEEDKAKKLAEKDKELRL 381
D + E + Y K++++ RR EE+ +R+ E+ +A++ E+ E+
Sbjct: 1316 YVDLRTHYSE-LTTLTSQYIKFISETLRRMEEE------ERLAEQQRAEE-RERLAEVEA 1367
Query: 382 EKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQ 441
E +RQL + Q + + +REAKE ++R E+ RR+
Sbjct: 1368 ALEKQRQLAEA-----HAQAKAQAEREAKELQQRMQEE-----------------VVRRE 1405
Query: 442 RL---AQEYRKQLQMQIAYQQQSQEAEKEEKRREFEA 475
AQ+ ++ +Q ++ +QS EAE + K R+ EA
Sbjct: 1406 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1442
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 90.9 bits (224), Expect = 3e-18
Identities = 120/517 (23%), Positives = 237/517 (45%), Gaps = 51/517 (9%)
Query: 2 YSQRFGTVQREVKGPTPKVVIVRSKPPKGQGAEHHLERIRRSHQKHNAILASIKSSERDR 61
++++ ++R ++ V +R + + + ER R ++ +K++E R
Sbjct: 1589 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW-QLKANEALR 1647
Query: 62 LKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNKLRELLA----LEENEYFTEMQ 117
L+ + ++ K L + K+ + RR K E L E E + Q
Sbjct: 1648 LRLQAEEVAQQKSLAQAEAEKQKEEAE----REARRRGKAEEQAVRQRELAEQELEKQRQ 1703
Query: 118 LKKETIEEKKDRMREKTKLLKEKNEKERQ-DFVAEKLDQQFRERC------EELRVELLS 170
L + T +++ +E +L E + E+Q + E+L + RE +EL EL
Sbjct: 1704 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1763
Query: 171 IH-QKKVCEERKAQIA----FNEELSRQKL-VEEQMFSKLWEEDRLAKEKREAQEARRQK 224
+ + +V KA+ E S+Q+L E F +L EE A+ + A+EA+RQ+
Sbjct: 1764 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE--AARLRALAEEAKRQR 1821
Query: 225 ELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQET 284
+L E + + + +A ++L E+ A + E+ ++K E E + +K+ +
Sbjct: 1822 QLAEED---------AARQRAEAERVLAEKLAAIGEAT--RLKTEAEIALKEKEAENERL 1870
Query: 285 RTILQKALQERIEHIQQEYRDEQDLNMKLVQ-RALQDLQEEADKKKQKREDMIREQK-IY 342
R + + +R +Q + + D+ +L Q R D E +++K ED +R+++ +
Sbjct: 1871 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD--SELERQKGLVEDTLRQRRQVE 1928
Query: 343 HKYLAQRREEEKAQEKEFDRILEEDKAKKLAE----KDKELRLEKEARRQLVDEVMCTRK 398
+ LA + EKA + + LE + + AE ++ LE +RQL E R+
Sbjct: 1929 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE-RRR 1987
Query: 399 LQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQM-QIAY 457
+ +E++Q+ +EE A ++K E ++ L + +E R+R QE +QLQ+ Q A
Sbjct: 1988 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2047
Query: 458 QQQSQEAEK------EEKRREFEAGVAANKMCLDKVQ 488
Q++ Q EK ++K +E + + + LD+++
Sbjct: 2048 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2084
Score = 85.9 bits (211), Expect = 8e-17
Identities = 121/487 (24%), Positives = 226/487 (46%), Gaps = 49/487 (10%)
Query: 34 EHHLERIRRSHQKHNAILASIKSSERDRLKAEWD----QHNDCKILDSLVRARIKDAVQG 89
E L + R+ ++ A+ AS + + + + E + + N L S +A ++ A Q
Sbjct: 1918 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1977
Query: 90 FIINIEERRNK-----LRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKE 144
+ EERR + +++ LA EE E + + E +E K ++ E+ + L+E+ E+E
Sbjct: 1978 QLAAEEERRRREAEERVQKSLAAEE-EAARQRKAALEEVERLKAKV-EEARRLRERAEQE 2035
Query: 145 --RQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFS 202
RQ +A++ Q+ R + EE + ++ QK+ +E + + + + Q E +
Sbjct: 2036 SARQLQLAQEAAQK-RLQAEE-KAHAFAVQQKE--QELQQTLQQEQSVLDQLRGEAEAAR 2091
Query: 203 KLWEEDRLAK--EKREAQEARRQKELMENTRLGLNAQITS-IKAQRQATQLLKEEE---A 256
+ EE A+ +REA ++RRQ E E + Q + +AQ A +L KE E A
Sbjct: 2092 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2151
Query: 257 RLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQR 316
R ++ A ++ + D ++ K +T+ QKA E+ + +E D L+
Sbjct: 2152 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2211
Query: 317 ALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKD 376
LQ L+ EA + ++R + E L R + + K RI E++A L +KD
Sbjct: 2212 ELQRLKAEATEAARQRSQVEEE-------LFSVRVQMEELSKLKARIEAENRALILRDKD 2264
Query: 377 KELRL---EKEARRQLVDEVM-CTRKLQVQEKLQREAKEQ--EERAMEQKHINESLK--- 427
R E E +Q+ +E + Q +L++ A+E ++RA+ +K + E ++
Sbjct: 2265 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2324
Query: 428 ---------ELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQS-QEAEKEEKRREFEAGV 477
EL ++KE + R QE ++Q+ Q+A + Q Q + E++R+ E
Sbjct: 2325 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2384
Query: 478 AANKMCL 484
A ++ L
Sbjct: 2385 EAERLKL 2391
Score = 85.5 bits (210), Expect = 1e-16
Identities = 110/422 (26%), Positives = 192/422 (45%), Gaps = 53/422 (12%)
Query: 96 ERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQ 155
E +L E EE E E+ E EK+ ++ E K + E+E A++L Q
Sbjct: 1349 EEEERLAEQQRAEERERLAEV----EAALEKQRQLAEAHAQAKAQAERE-----AKELQQ 1399
Query: 156 QFRE---RCEELRVELLSIHQKKVCEERKAQIAFNEEL-----SRQKLVEEQMFSKLWEE 207
+ +E R EE V+ + QK+ +E Q+ + E +RQ E+ ++ EE
Sbjct: 1400 RMQEEVVRREEAAVD--AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1457
Query: 208 DRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIK 267
R+ + + EA E RQ+ E L A+ +AQ++ Q E R V+ + +Q K
Sbjct: 1458 IRVVRLQLEATE--RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ-DESQRK 1514
Query: 268 HENEQDMLKKQKAKQETRTILQKALQE------RIEHIQQEYRDEQDLNMKLVQRALQDL 321
+ E ++ + KA+ E Q+ALQ + E ++ R + + VQ AL+
Sbjct: 1515 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1574
Query: 322 QEEADKKKQ--------KREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLA 373
Q A+ + Q K + R + H +AQ REE E+ + E ++A++ A
Sbjct: 1575 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE---AERRAQQQAEAERAREEA 1631
Query: 374 EKDKE---LRLEKEARRQLVDEVMCTRKLQVQ-------EKLQREAKEQ---EERAMEQK 420
E++ E L+ + R +L E + +K Q E+ +REA+ + EE+A+ Q+
Sbjct: 1632 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1691
Query: 421 HINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAY-QQQSQEAEKEEKRREFEAGVAA 479
+ E E + E A+++ A++ +L+ + +QQ Q E+E R + EA A
Sbjct: 1692 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1751
Query: 480 NK 481
K
Sbjct: 1752 QK 1753
Score = 79.7 bits (195), Expect = 6e-15
Identities = 115/542 (21%), Positives = 227/542 (41%), Gaps = 98/542 (18%)
Query: 33 AEHHLERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFII 92
A+ ER+RR Q + + R+KAE + + + R A++ +
Sbjct: 1496 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE--------KQRALQALEELRL 1547
Query: 93 NIEERRNKLRELLALEENEYFTEMQLKKET--------IEEKKDRMREKTKLLKEKNEKE 144
EE +LR+ E E ++Q+ ET ++ K+ EKT L+ ++E
Sbjct: 1548 QAEEAERRLRQA----EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1603
Query: 145 -------RQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVE 197
R++ Q ER E L Q K E + ++ E ++ L +
Sbjct: 1604 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1663
Query: 198 EQMFSKLWEEDRLAKEKREA------------QEARRQKELMENT---RLGLNAQITSIK 242
+ + E +R A+ + +A QE +Q++L E T RL ++ ++
Sbjct: 1664 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1723
Query: 243 AQ----RQATQLLKEEEARL-------------VESNNAQIKHENEQDMLKKQKAKQETR 285
A+ Q QLL+EE ARL +E+ A+++ E E + K +A++E+R
Sbjct: 1724 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1783
Query: 286 TILQKALQE----------------RIEHIQQEYRDEQDLNMKLVQRALQDLQE------ 323
+ +K+ Q R+ + +E + ++ L + R + +
Sbjct: 1784 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1843
Query: 324 ----EADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKA---KKLAEKD 376
EA + K + E ++E++ ++ L + E+E Q + + + KA ++LA+
Sbjct: 1844 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1903
Query: 377 KELRLEKEARRQLVDEVMCTRKLQVQEKL-------QREAKEQEERAMEQKHINESLKEL 429
K E E ++ LV++ + R+ QV+E++ ++ A + E +E I + ++
Sbjct: 1904 KASDSELERQKGLVEDTLRQRR-QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 1962
Query: 430 --NCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKV 487
+ E+ E A RQR ++ + + + Q A +EE R+ +A + + KV
Sbjct: 1963 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2022
Query: 488 QE 489
+E
Sbjct: 2023 EE 2024
Score = 79.0 bits (193), Expect = 1e-14
Identities = 88/386 (22%), Positives = 183/386 (47%), Gaps = 21/386 (5%)
Query: 92 INIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKN-EKERQDFVA 150
I ++E+ + L L E+E F +L+++ + K D +L K + E ERQ +
Sbjct: 1858 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1917
Query: 151 EKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSR-QKLVEEQMFSKLWEEDR 209
E +Q R+ EE+ + L + +K + + ++ EL R + E+ + SK E
Sbjct: 1918 EDTLRQRRQVEEEI-LALKASFEKAAAGKAELEL----ELGRIRSNAEDTLRSKEQAELE 1972
Query: 210 LAKEKR-EAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKH 268
A++++ A+E RR++E E + L A+ + + ++ A + ++ +A++ E+ +++
Sbjct: 1973 AARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR--RLRE 2030
Query: 269 ENEQDMLKKQKAKQETRTILQKALQ-ERIEHIQQEYRDEQDLNMKLVQR--ALQDLQEEA 325
EQ+ ++ + QE QK LQ E H + EQ+L L Q L L+ EA
Sbjct: 2031 RAEQESARQLQLAQEAA---QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2087
Query: 326 DKKKQKREDMIREQKIYHKYLAQRR----EEEKAQEKEFDRILEEDKAKKLAEKDKELRL 381
+ ++ E+ + + AQ R E E+ ++ ++ +A+ AEK ++
Sbjct: 2088 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2147
Query: 382 EKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQ 441
++ ARR ++ +K ++++ K E+ ++ + + L L + +E ++
Sbjct: 2148 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2207
Query: 442 RLAQE-YRKQLQMQIAYQQQSQEAEK 466
L +E R + + A +Q+SQ E+
Sbjct: 2208 LLDEELQRLKAEATEAARQRSQVEEE 2233
Score = 72.8 bits (177), Expect = 7e-13
Identities = 65/280 (23%), Positives = 143/280 (51%), Gaps = 29/280 (10%)
Query: 194 KLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKE 253
K + E + ++ EE+RLA+++R A+E R E+ +++ QRQ + +
Sbjct: 1339 KFISETL-RRMEEEERLAEQQR-AEERERLAEVE-----------AALEKQRQLAEAHAQ 1385
Query: 254 EEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKL 313
+A+ E +++ +++++++++A + + ++++QE ++ ++Q E ++ K
Sbjct: 1386 AKAQ-AEREAKELQQRMQEEVVRREEAAVDAQQ-QKRSIQEELQQLRQS--SEAEIQAKA 1441
Query: 314 VQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLA 373
Q E A++ + + E+ IR ++ + ++R + + + EE +A+K
Sbjct: 1442 RQA------EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1495
Query: 374 EKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEE 433
+++ RL RRQ+ DE RK Q + +L K + E A E++ ++L+EL +
Sbjct: 1496 AQEEAERL----RRQVQDESQ--RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1549
Query: 434 KENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREF 473
+E R ++ E +Q+Q+ + Q+S EAE + KR F
Sbjct: 1550 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1589
Score = 71.6 bits (174), Expect = 2e-12
Identities = 112/526 (21%), Positives = 218/526 (41%), Gaps = 92/526 (17%)
Query: 41 RRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNK 100
+RS + ++ E +LKA + N IL R KD Q F+ E+ +
Sbjct: 2226 QRSQVEEELFSVRVQMEELSKLKARIEAENRALIL------RDKDNTQRFLQEEAEKMKQ 2279
Query: 101 LRE--------------LLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQ 146
+ E L L E + + L ++ ++EK ++E T+L E ++Q
Sbjct: 2280 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2339
Query: 147 DFVAEKLDQQFRERCEELRVELLSI---HQKKVCEERKAQIAFNEELSRQKL-VEEQMFS 202
+A++ ++ +E E++ +L Q+ + ER+ Q+ + E R KL V E +
Sbjct: 2340 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2399
Query: 203 KLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQIT---SIKAQRQAT----------- 248
+ E+ + +++A+E E + T L ++T +++ QRQ +
Sbjct: 2400 QARAEEDAQRFRKQAEEIG---EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2456
Query: 249 -QLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQ------- 300
+L +E+E E+ Q+K E E +++++ QET+ + Q L E+ +Q
Sbjct: 2457 AELEREKEKLQQEAKLLQLKSE-EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2515
Query: 301 ----------------QEYRDEQDLNMKLVQRALQDL---QEEADKKKQKREDMIR-EQK 340
Q+ R+EQ + +++ Q L EEA +++ + E+ +R +Q+
Sbjct: 2516 EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE 2575
Query: 341 IYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKL- 399
+ QRR++E+ +E R+ E+ +L E+ L + +V T+ L
Sbjct: 2576 ELQQLEQQRRQQEELLAEENQRLREQ---LQLLEEQHRAAL-AHSEEVTASQVAATKTLP 2631
Query: 400 QVQEKLQREAKEQEER----AMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQI 455
++ L A E E + +K + L+E E QRLAQ
Sbjct: 2632 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL---QRLAQ---------- 2678
Query: 456 AYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEVLSTHQVLPQNI 501
+ + A +E+ R + + + L E LS + L + +
Sbjct: 2679 GHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQL 2724
Score = 48.1 bits (113), Expect = 2e-05
Identities = 80/337 (23%), Positives = 143/337 (42%), Gaps = 63/337 (18%)
Query: 149 VAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEED 208
V E+L Q+ ER ++ VE ++ E +A +A Q V ++ +L +
Sbjct: 1163 VGERLQQRHGER--DVEVERWRERVAQLLERWQAVLA-------QTDVRQRELEQLGRQL 1213
Query: 209 RLAKEKREA-----QEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNN 263
R +E + Q+ARR++E ++ L A +++ Q + Q L EE
Sbjct: 1214 RYYRESADPLGAWLQDARRRQEQIQAMPL---ADSQAVREQLRQEQALLEE--------- 1261
Query: 264 AQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQE 323
I+ E+ ++ AKQ I LQ Q E K+ + +QE
Sbjct: 1262 --IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1319
Query: 324 EADKKKQKREDMIREQKIYHKYLAQ--RREEEKAQEKEFDRILEEDKAKKLAEKDKELRL 381
D + E + Y K++++ RR EE+ +R+ E+ +A++ E+ E+
Sbjct: 1320 YVDLRTHYSE-LTTLTSQYIKFISETLRRMEEE------ERLAEQQRAEE-RERLAEVEA 1371
Query: 382 EKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQ 441
E +RQL + Q + + +REAKE ++R E+ RR+
Sbjct: 1372 ALEKQRQLAEA-----HAQAKAQAEREAKELQQRMQEE-----------------VVRRE 1409
Query: 442 RL---AQEYRKQLQMQIAYQQQSQEAEKEEKRREFEA 475
AQ+ ++ +Q ++ +QS EAE + K R+ EA
Sbjct: 1410 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1446
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 90.9 bits (224), Expect = 3e-18
Identities = 120/517 (23%), Positives = 237/517 (45%), Gaps = 51/517 (9%)
Query: 2 YSQRFGTVQREVKGPTPKVVIVRSKPPKGQGAEHHLERIRRSHQKHNAILASIKSSERDR 61
++++ ++R ++ V +R + + + ER R ++ +K++E R
Sbjct: 1585 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW-QLKANEALR 1643
Query: 62 LKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNKLRELLA----LEENEYFTEMQ 117
L+ + ++ K L + K+ + RR K E L E E + Q
Sbjct: 1644 LRLQAEEVAQQKSLAQAEAEKQKEEAE----REARRRGKAEEQAVRQRELAEQELEKQRQ 1699
Query: 118 LKKETIEEKKDRMREKTKLLKEKNEKERQ-DFVAEKLDQQFRERC------EELRVELLS 170
L + T +++ +E +L E + E+Q + E+L + RE +EL EL
Sbjct: 1700 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1759
Query: 171 IH-QKKVCEERKAQIA----FNEELSRQKL-VEEQMFSKLWEEDRLAKEKREAQEARRQK 224
+ + +V KA+ E S+Q+L E F +L EE A+ + A+EA+RQ+
Sbjct: 1760 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE--AARLRALAEEAKRQR 1817
Query: 225 ELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQET 284
+L E + + + +A ++L E+ A + E+ ++K E E + +K+ +
Sbjct: 1818 QLAEED---------AARQRAEAERVLAEKLAAIGEAT--RLKTEAEIALKEKEAENERL 1866
Query: 285 RTILQKALQERIEHIQQEYRDEQDLNMKLVQ-RALQDLQEEADKKKQKREDMIREQK-IY 342
R + + +R +Q + + D+ +L Q R D E +++K ED +R+++ +
Sbjct: 1867 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD--SELERQKGLVEDTLRQRRQVE 1924
Query: 343 HKYLAQRREEEKAQEKEFDRILEEDKAKKLAE----KDKELRLEKEARRQLVDEVMCTRK 398
+ LA + EKA + + LE + + AE ++ LE +RQL E R+
Sbjct: 1925 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE-RRR 1983
Query: 399 LQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQM-QIAY 457
+ +E++Q+ +EE A ++K E ++ L + +E R+R QE +QLQ+ Q A
Sbjct: 1984 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2043
Query: 458 QQQSQEAEK------EEKRREFEAGVAANKMCLDKVQ 488
Q++ Q EK ++K +E + + + LD+++
Sbjct: 2044 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2080
Score = 85.9 bits (211), Expect = 8e-17
Identities = 121/487 (24%), Positives = 226/487 (46%), Gaps = 49/487 (10%)
Query: 34 EHHLERIRRSHQKHNAILASIKSSERDRLKAEWD----QHNDCKILDSLVRARIKDAVQG 89
E L + R+ ++ A+ AS + + + + E + + N L S +A ++ A Q
Sbjct: 1914 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1973
Query: 90 FIINIEERRNK-----LRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKE 144
+ EERR + +++ LA EE E + + E +E K ++ E+ + L+E+ E+E
Sbjct: 1974 QLAAEEERRRREAEERVQKSLAAEE-EAARQRKAALEEVERLKAKV-EEARRLRERAEQE 2031
Query: 145 --RQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFS 202
RQ +A++ Q+ R + EE + ++ QK+ +E + + + + Q E +
Sbjct: 2032 SARQLQLAQEAAQK-RLQAEE-KAHAFAVQQKE--QELQQTLQQEQSVLDQLRGEAEAAR 2087
Query: 203 KLWEEDRLAK--EKREAQEARRQKELMENTRLGLNAQITS-IKAQRQATQLLKEEE---A 256
+ EE A+ +REA ++RRQ E E + Q + +AQ A +L KE E A
Sbjct: 2088 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2147
Query: 257 RLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQR 316
R ++ A ++ + D ++ K +T+ QKA E+ + +E D L+
Sbjct: 2148 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2207
Query: 317 ALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKD 376
LQ L+ EA + ++R + E L R + + K RI E++A L +KD
Sbjct: 2208 ELQRLKAEATEAARQRSQVEEE-------LFSVRVQMEELSKLKARIEAENRALILRDKD 2260
Query: 377 KELRL---EKEARRQLVDEVM-CTRKLQVQEKLQREAKEQ--EERAMEQKHINESLK--- 427
R E E +Q+ +E + Q +L++ A+E ++RA+ +K + E ++
Sbjct: 2261 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2320
Query: 428 ---------ELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQS-QEAEKEEKRREFEAGV 477
EL ++KE + R QE ++Q+ Q+A + Q Q + E++R+ E
Sbjct: 2321 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2380
Query: 478 AANKMCL 484
A ++ L
Sbjct: 2381 EAERLKL 2387
Score = 85.5 bits (210), Expect = 1e-16
Identities = 110/422 (26%), Positives = 192/422 (45%), Gaps = 53/422 (12%)
Query: 96 ERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQ 155
E +L E EE E E+ E EK+ ++ E K + E+E A++L Q
Sbjct: 1345 EEEERLAEQQRAEERERLAEV----EAALEKQRQLAEAHAQAKAQAERE-----AKELQQ 1395
Query: 156 QFRE---RCEELRVELLSIHQKKVCEERKAQIAFNEEL-----SRQKLVEEQMFSKLWEE 207
+ +E R EE V+ + QK+ +E Q+ + E +RQ E+ ++ EE
Sbjct: 1396 RMQEEVVRREEAAVD--AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1453
Query: 208 DRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIK 267
R+ + + EA E RQ+ E L A+ +AQ++ Q E R V+ + +Q K
Sbjct: 1454 IRVVRLQLEATE--RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ-DESQRK 1510
Query: 268 HENEQDMLKKQKAKQETRTILQKALQE------RIEHIQQEYRDEQDLNMKLVQRALQDL 321
+ E ++ + KA+ E Q+ALQ + E ++ R + + VQ AL+
Sbjct: 1511 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1570
Query: 322 QEEADKKKQ--------KREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLA 373
Q A+ + Q K + R + H +AQ REE E+ + E ++A++ A
Sbjct: 1571 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE---AERRAQQQAEAERAREEA 1627
Query: 374 EKDKE---LRLEKEARRQLVDEVMCTRKLQVQ-------EKLQREAKEQ---EERAMEQK 420
E++ E L+ + R +L E + +K Q E+ +REA+ + EE+A+ Q+
Sbjct: 1628 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1687
Query: 421 HINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAY-QQQSQEAEKEEKRREFEAGVAA 479
+ E E + E A+++ A++ +L+ + +QQ Q E+E R + EA A
Sbjct: 1688 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1747
Query: 480 NK 481
K
Sbjct: 1748 QK 1749
Score = 79.7 bits (195), Expect = 6e-15
Identities = 115/542 (21%), Positives = 227/542 (41%), Gaps = 98/542 (18%)
Query: 33 AEHHLERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFII 92
A+ ER+RR Q + + R+KAE + + + R A++ +
Sbjct: 1492 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE--------KQRALQALEELRL 1543
Query: 93 NIEERRNKLRELLALEENEYFTEMQLKKET--------IEEKKDRMREKTKLLKEKNEKE 144
EE +LR+ E E ++Q+ ET ++ K+ EKT L+ ++E
Sbjct: 1544 QAEEAERRLRQA----EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1599
Query: 145 -------RQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVE 197
R++ Q ER E L Q K E + ++ E ++ L +
Sbjct: 1600 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1659
Query: 198 EQMFSKLWEEDRLAKEKREA------------QEARRQKELMENT---RLGLNAQITSIK 242
+ + E +R A+ + +A QE +Q++L E T RL ++ ++
Sbjct: 1660 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1719
Query: 243 AQ----RQATQLLKEEEARL-------------VESNNAQIKHENEQDMLKKQKAKQETR 285
A+ Q QLL+EE ARL +E+ A+++ E E + K +A++E+R
Sbjct: 1720 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1779
Query: 286 TILQKALQE----------------RIEHIQQEYRDEQDLNMKLVQRALQDLQE------ 323
+ +K+ Q R+ + +E + ++ L + R + +
Sbjct: 1780 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1839
Query: 324 ----EADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKA---KKLAEKD 376
EA + K + E ++E++ ++ L + E+E Q + + + KA ++LA+
Sbjct: 1840 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1899
Query: 377 KELRLEKEARRQLVDEVMCTRKLQVQEKL-------QREAKEQEERAMEQKHINESLKEL 429
K E E ++ LV++ + R+ QV+E++ ++ A + E +E I + ++
Sbjct: 1900 KASDSELERQKGLVEDTLRQRR-QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 1958
Query: 430 --NCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKV 487
+ E+ E A RQR ++ + + + Q A +EE R+ +A + + KV
Sbjct: 1959 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2018
Query: 488 QE 489
+E
Sbjct: 2019 EE 2020
Score = 79.0 bits (193), Expect = 1e-14
Identities = 88/386 (22%), Positives = 183/386 (47%), Gaps = 21/386 (5%)
Query: 92 INIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKN-EKERQDFVA 150
I ++E+ + L L E+E F +L+++ + K D +L K + E ERQ +
Sbjct: 1854 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1913
Query: 151 EKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSR-QKLVEEQMFSKLWEEDR 209
E +Q R+ EE+ + L + +K + + ++ EL R + E+ + SK E
Sbjct: 1914 EDTLRQRRQVEEEI-LALKASFEKAAAGKAELEL----ELGRIRSNAEDTLRSKEQAELE 1968
Query: 210 LAKEKR-EAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKH 268
A++++ A+E RR++E E + L A+ + + ++ A + ++ +A++ E+ +++
Sbjct: 1969 AARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR--RLRE 2026
Query: 269 ENEQDMLKKQKAKQETRTILQKALQ-ERIEHIQQEYRDEQDLNMKLVQR--ALQDLQEEA 325
EQ+ ++ + QE QK LQ E H + EQ+L L Q L L+ EA
Sbjct: 2027 RAEQESARQLQLAQEAA---QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2083
Query: 326 DKKKQKREDMIREQKIYHKYLAQRR----EEEKAQEKEFDRILEEDKAKKLAEKDKELRL 381
+ ++ E+ + + AQ R E E+ ++ ++ +A+ AEK ++
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2143
Query: 382 EKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQ 441
++ ARR ++ +K ++++ K E+ ++ + + L L + +E ++
Sbjct: 2144 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2203
Query: 442 RLAQE-YRKQLQMQIAYQQQSQEAEK 466
L +E R + + A +Q+SQ E+
Sbjct: 2204 LLDEELQRLKAEATEAARQRSQVEEE 2229
Score = 72.8 bits (177), Expect = 7e-13
Identities = 65/280 (23%), Positives = 143/280 (51%), Gaps = 29/280 (10%)
Query: 194 KLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKE 253
K + E + ++ EE+RLA+++R A+E R E+ +++ QRQ + +
Sbjct: 1335 KFISETL-RRMEEEERLAEQQR-AEERERLAEVE-----------AALEKQRQLAEAHAQ 1381
Query: 254 EEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKL 313
+A+ E +++ +++++++++A + + ++++QE ++ ++Q E ++ K
Sbjct: 1382 AKAQ-AEREAKELQQRMQEEVVRREEAAVDAQQ-QKRSIQEELQQLRQS--SEAEIQAKA 1437
Query: 314 VQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLA 373
Q E A++ + + E+ IR ++ + ++R + + + EE +A+K
Sbjct: 1438 RQA------EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1491
Query: 374 EKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEE 433
+++ RL RRQ+ DE RK Q + +L K + E A E++ ++L+EL +
Sbjct: 1492 AQEEAERL----RRQVQDESQ--RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1545
Query: 434 KENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREF 473
+E R ++ E +Q+Q+ + Q+S EAE + KR F
Sbjct: 1546 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1585
Score = 71.6 bits (174), Expect = 2e-12
Identities = 112/526 (21%), Positives = 218/526 (41%), Gaps = 92/526 (17%)
Query: 41 RRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNK 100
+RS + ++ E +LKA + N IL R KD Q F+ E+ +
Sbjct: 2222 QRSQVEEELFSVRVQMEELSKLKARIEAENRALIL------RDKDNTQRFLQEEAEKMKQ 2275
Query: 101 LRE--------------LLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQ 146
+ E L L E + + L ++ ++EK ++E T+L E ++Q
Sbjct: 2276 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2335
Query: 147 DFVAEKLDQQFRERCEELRVELLSI---HQKKVCEERKAQIAFNEELSRQKL-VEEQMFS 202
+A++ ++ +E E++ +L Q+ + ER+ Q+ + E R KL V E +
Sbjct: 2336 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2395
Query: 203 KLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQIT---SIKAQRQAT----------- 248
+ E+ + +++A+E E + T L ++T +++ QRQ +
Sbjct: 2396 QARAEEDAQRFRKQAEEIG---EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2452
Query: 249 -QLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQ------- 300
+L +E+E E+ Q+K E E +++++ QET+ + Q L E+ +Q
Sbjct: 2453 AELEREKEKLQQEAKLLQLKSE-EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2511
Query: 301 ----------------QEYRDEQDLNMKLVQRALQDL---QEEADKKKQKREDMIR-EQK 340
Q+ R+EQ + +++ Q L EEA +++ + E+ +R +Q+
Sbjct: 2512 EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE 2571
Query: 341 IYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKL- 399
+ QRR++E+ +E R+ E+ +L E+ L + +V T+ L
Sbjct: 2572 ELQQLEQQRRQQEELLAEENQRLREQ---LQLLEEQHRAAL-AHSEEVTASQVAATKTLP 2627
Query: 400 QVQEKLQREAKEQEER----AMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQI 455
++ L A E E + +K + L+E E QRLAQ
Sbjct: 2628 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL---QRLAQ---------- 2674
Query: 456 AYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEVLSTHQVLPQNI 501
+ + A +E+ R + + + L E LS + L + +
Sbjct: 2675 GHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQL 2720
Score = 48.1 bits (113), Expect = 2e-05
Identities = 80/337 (23%), Positives = 143/337 (42%), Gaps = 63/337 (18%)
Query: 149 VAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEED 208
V E+L Q+ ER ++ VE ++ E +A +A Q V ++ +L +
Sbjct: 1159 VGERLQQRHGER--DVEVERWRERVAQLLERWQAVLA-------QTDVRQRELEQLGRQL 1209
Query: 209 RLAKEKREA-----QEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNN 263
R +E + Q+ARR++E ++ L A +++ Q + Q L EE
Sbjct: 1210 RYYRESADPLGAWLQDARRRQEQIQAMPL---ADSQAVREQLRQEQALLEE--------- 1257
Query: 264 AQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQE 323
I+ E+ ++ AKQ I LQ Q E K+ + +QE
Sbjct: 1258 --IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1315
Query: 324 EADKKKQKREDMIREQKIYHKYLAQ--RREEEKAQEKEFDRILEEDKAKKLAEKDKELRL 381
D + E + Y K++++ RR EE+ +R+ E+ +A++ E+ E+
Sbjct: 1316 YVDLRTHYSE-LTTLTSQYIKFISETLRRMEEE------ERLAEQQRAEE-RERLAEVEA 1367
Query: 382 EKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQ 441
E +RQL + Q + + +REAKE ++R E+ RR+
Sbjct: 1368 ALEKQRQLAEA-----HAQAKAQAEREAKELQQRMQEE-----------------VVRRE 1405
Query: 442 RL---AQEYRKQLQMQIAYQQQSQEAEKEEKRREFEA 475
AQ+ ++ +Q ++ +QS EAE + K R+ EA
Sbjct: 1406 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1442
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 90.9 bits (224), Expect = 3e-18
Identities = 120/517 (23%), Positives = 237/517 (45%), Gaps = 51/517 (9%)
Query: 2 YSQRFGTVQREVKGPTPKVVIVRSKPPKGQGAEHHLERIRRSHQKHNAILASIKSSERDR 61
++++ ++R ++ V +R + + + ER R ++ +K++E R
Sbjct: 1553 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW-QLKANEALR 1611
Query: 62 LKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNKLRELLA----LEENEYFTEMQ 117
L+ + ++ K L + K+ + RR K E L E E + Q
Sbjct: 1612 LRLQAEEVAQQKSLAQAEAEKQKEEAE----REARRRGKAEEQAVRQRELAEQELEKQRQ 1667
Query: 118 LKKETIEEKKDRMREKTKLLKEKNEKERQ-DFVAEKLDQQFRERC------EELRVELLS 170
L + T +++ +E +L E + E+Q + E+L + RE +EL EL
Sbjct: 1668 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1727
Query: 171 IH-QKKVCEERKAQIA----FNEELSRQKL-VEEQMFSKLWEEDRLAKEKREAQEARRQK 224
+ + +V KA+ E S+Q+L E F +L EE A+ + A+EA+RQ+
Sbjct: 1728 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE--AARLRALAEEAKRQR 1785
Query: 225 ELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQET 284
+L E + + + +A ++L E+ A + E+ ++K E E + +K+ +
Sbjct: 1786 QLAEED---------AARQRAEAERVLAEKLAAIGEAT--RLKTEAEIALKEKEAENERL 1834
Query: 285 RTILQKALQERIEHIQQEYRDEQDLNMKLVQ-RALQDLQEEADKKKQKREDMIREQK-IY 342
R + + +R +Q + + D+ +L Q R D E +++K ED +R+++ +
Sbjct: 1835 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD--SELERQKGLVEDTLRQRRQVE 1892
Query: 343 HKYLAQRREEEKAQEKEFDRILEEDKAKKLAE----KDKELRLEKEARRQLVDEVMCTRK 398
+ LA + EKA + + LE + + AE ++ LE +RQL E R+
Sbjct: 1893 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE-RRR 1951
Query: 399 LQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQM-QIAY 457
+ +E++Q+ +EE A ++K E ++ L + +E R+R QE +QLQ+ Q A
Sbjct: 1952 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2011
Query: 458 QQQSQEAEK------EEKRREFEAGVAANKMCLDKVQ 488
Q++ Q EK ++K +E + + + LD+++
Sbjct: 2012 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2048
Score = 85.9 bits (211), Expect = 8e-17
Identities = 121/487 (24%), Positives = 226/487 (46%), Gaps = 49/487 (10%)
Query: 34 EHHLERIRRSHQKHNAILASIKSSERDRLKAEWD----QHNDCKILDSLVRARIKDAVQG 89
E L + R+ ++ A+ AS + + + + E + + N L S +A ++ A Q
Sbjct: 1882 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1941
Query: 90 FIINIEERRNK-----LRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKE 144
+ EERR + +++ LA EE E + + E +E K ++ E+ + L+E+ E+E
Sbjct: 1942 QLAAEEERRRREAEERVQKSLAAEE-EAARQRKAALEEVERLKAKV-EEARRLRERAEQE 1999
Query: 145 --RQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFS 202
RQ +A++ Q+ R + EE + ++ QK+ +E + + + + Q E +
Sbjct: 2000 SARQLQLAQEAAQK-RLQAEE-KAHAFAVQQKE--QELQQTLQQEQSVLDQLRGEAEAAR 2055
Query: 203 KLWEEDRLAK--EKREAQEARRQKELMENTRLGLNAQITS-IKAQRQATQLLKEEE---A 256
+ EE A+ +REA ++RRQ E E + Q + +AQ A +L KE E A
Sbjct: 2056 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2115
Query: 257 RLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQR 316
R ++ A ++ + D ++ K +T+ QKA E+ + +E D L+
Sbjct: 2116 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2175
Query: 317 ALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKD 376
LQ L+ EA + ++R + E L R + + K RI E++A L +KD
Sbjct: 2176 ELQRLKAEATEAARQRSQVEEE-------LFSVRVQMEELSKLKARIEAENRALILRDKD 2228
Query: 377 KELRL---EKEARRQLVDEVM-CTRKLQVQEKLQREAKEQ--EERAMEQKHINESLK--- 427
R E E +Q+ +E + Q +L++ A+E ++RA+ +K + E ++
Sbjct: 2229 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2288
Query: 428 ---------ELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQS-QEAEKEEKRREFEAGV 477
EL ++KE + R QE ++Q+ Q+A + Q Q + E++R+ E
Sbjct: 2289 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2348
Query: 478 AANKMCL 484
A ++ L
Sbjct: 2349 EAERLKL 2355
Score = 85.5 bits (210), Expect = 1e-16
Identities = 110/422 (26%), Positives = 192/422 (45%), Gaps = 53/422 (12%)
Query: 96 ERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQ 155
E +L E EE E E+ E EK+ ++ E K + E+E A++L Q
Sbjct: 1313 EEEERLAEQQRAEERERLAEV----EAALEKQRQLAEAHAQAKAQAERE-----AKELQQ 1363
Query: 156 QFRE---RCEELRVELLSIHQKKVCEERKAQIAFNEEL-----SRQKLVEEQMFSKLWEE 207
+ +E R EE V+ + QK+ +E Q+ + E +RQ E+ ++ EE
Sbjct: 1364 RMQEEVVRREEAAVD--AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1421
Query: 208 DRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIK 267
R+ + + EA E RQ+ E L A+ +AQ++ Q E R V+ + +Q K
Sbjct: 1422 IRVVRLQLEATE--RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ-DESQRK 1478
Query: 268 HENEQDMLKKQKAKQETRTILQKALQE------RIEHIQQEYRDEQDLNMKLVQRALQDL 321
+ E ++ + KA+ E Q+ALQ + E ++ R + + VQ AL+
Sbjct: 1479 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1538
Query: 322 QEEADKKKQ--------KREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLA 373
Q A+ + Q K + R + H +AQ REE E+ + E ++A++ A
Sbjct: 1539 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE---AERRAQQQAEAERAREEA 1595
Query: 374 EKDKE---LRLEKEARRQLVDEVMCTRKLQVQ-------EKLQREAKEQ---EERAMEQK 420
E++ E L+ + R +L E + +K Q E+ +REA+ + EE+A+ Q+
Sbjct: 1596 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1655
Query: 421 HINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAY-QQQSQEAEKEEKRREFEAGVAA 479
+ E E + E A+++ A++ +L+ + +QQ Q E+E R + EA A
Sbjct: 1656 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1715
Query: 480 NK 481
K
Sbjct: 1716 QK 1717
Score = 79.7 bits (195), Expect = 6e-15
Identities = 115/542 (21%), Positives = 227/542 (41%), Gaps = 98/542 (18%)
Query: 33 AEHHLERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFII 92
A+ ER+RR Q + + R+KAE + + + R A++ +
Sbjct: 1460 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE--------KQRALQALEELRL 1511
Query: 93 NIEERRNKLRELLALEENEYFTEMQLKKET--------IEEKKDRMREKTKLLKEKNEKE 144
EE +LR+ E E ++Q+ ET ++ K+ EKT L+ ++E
Sbjct: 1512 QAEEAERRLRQA----EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1567
Query: 145 -------RQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVE 197
R++ Q ER E L Q K E + ++ E ++ L +
Sbjct: 1568 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1627
Query: 198 EQMFSKLWEEDRLAKEKREA------------QEARRQKELMENT---RLGLNAQITSIK 242
+ + E +R A+ + +A QE +Q++L E T RL ++ ++
Sbjct: 1628 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1687
Query: 243 AQ----RQATQLLKEEEARL-------------VESNNAQIKHENEQDMLKKQKAKQETR 285
A+ Q QLL+EE ARL +E+ A+++ E E + K +A++E+R
Sbjct: 1688 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1747
Query: 286 TILQKALQE----------------RIEHIQQEYRDEQDLNMKLVQRALQDLQE------ 323
+ +K+ Q R+ + +E + ++ L + R + +
Sbjct: 1748 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1807
Query: 324 ----EADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKA---KKLAEKD 376
EA + K + E ++E++ ++ L + E+E Q + + + KA ++LA+
Sbjct: 1808 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1867
Query: 377 KELRLEKEARRQLVDEVMCTRKLQVQEKL-------QREAKEQEERAMEQKHINESLKEL 429
K E E ++ LV++ + R+ QV+E++ ++ A + E +E I + ++
Sbjct: 1868 KASDSELERQKGLVEDTLRQRR-QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 1926
Query: 430 --NCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKV 487
+ E+ E A RQR ++ + + + Q A +EE R+ +A + + KV
Sbjct: 1927 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 1986
Query: 488 QE 489
+E
Sbjct: 1987 EE 1988
Score = 79.0 bits (193), Expect = 1e-14
Identities = 88/386 (22%), Positives = 183/386 (47%), Gaps = 21/386 (5%)
Query: 92 INIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKN-EKERQDFVA 150
I ++E+ + L L E+E F +L+++ + K D +L K + E ERQ +
Sbjct: 1822 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1881
Query: 151 EKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSR-QKLVEEQMFSKLWEEDR 209
E +Q R+ EE+ + L + +K + + ++ EL R + E+ + SK E
Sbjct: 1882 EDTLRQRRQVEEEI-LALKASFEKAAAGKAELEL----ELGRIRSNAEDTLRSKEQAELE 1936
Query: 210 LAKEKR-EAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKH 268
A++++ A+E RR++E E + L A+ + + ++ A + ++ +A++ E+ +++
Sbjct: 1937 AARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR--RLRE 1994
Query: 269 ENEQDMLKKQKAKQETRTILQKALQ-ERIEHIQQEYRDEQDLNMKLVQR--ALQDLQEEA 325
EQ+ ++ + QE QK LQ E H + EQ+L L Q L L+ EA
Sbjct: 1995 RAEQESARQLQLAQEAA---QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2051
Query: 326 DKKKQKREDMIREQKIYHKYLAQRR----EEEKAQEKEFDRILEEDKAKKLAEKDKELRL 381
+ ++ E+ + + AQ R E E+ ++ ++ +A+ AEK ++
Sbjct: 2052 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2111
Query: 382 EKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQ 441
++ ARR ++ +K ++++ K E+ ++ + + L L + +E ++
Sbjct: 2112 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2171
Query: 442 RLAQE-YRKQLQMQIAYQQQSQEAEK 466
L +E R + + A +Q+SQ E+
Sbjct: 2172 LLDEELQRLKAEATEAARQRSQVEEE 2197
Score = 72.8 bits (177), Expect = 7e-13
Identities = 65/280 (23%), Positives = 143/280 (51%), Gaps = 29/280 (10%)
Query: 194 KLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKE 253
K + E + ++ EE+RLA+++R A+E R E+ +++ QRQ + +
Sbjct: 1303 KFISETL-RRMEEEERLAEQQR-AEERERLAEVE-----------AALEKQRQLAEAHAQ 1349
Query: 254 EEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKL 313
+A+ E +++ +++++++++A + + ++++QE ++ ++Q E ++ K
Sbjct: 1350 AKAQ-AEREAKELQQRMQEEVVRREEAAVDAQQ-QKRSIQEELQQLRQS--SEAEIQAKA 1405
Query: 314 VQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLA 373
Q E A++ + + E+ IR ++ + ++R + + + EE +A+K
Sbjct: 1406 RQA------EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1459
Query: 374 EKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEE 433
+++ RL RRQ+ DE RK Q + +L K + E A E++ ++L+EL +
Sbjct: 1460 AQEEAERL----RRQVQDESQ--RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1513
Query: 434 KENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREF 473
+E R ++ E +Q+Q+ + Q+S EAE + KR F
Sbjct: 1514 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1553
Score = 71.6 bits (174), Expect = 2e-12
Identities = 112/526 (21%), Positives = 218/526 (41%), Gaps = 92/526 (17%)
Query: 41 RRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNK 100
+RS + ++ E +LKA + N IL R KD Q F+ E+ +
Sbjct: 2190 QRSQVEEELFSVRVQMEELSKLKARIEAENRALIL------RDKDNTQRFLQEEAEKMKQ 2243
Query: 101 LRE--------------LLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQ 146
+ E L L E + + L ++ ++EK ++E T+L E ++Q
Sbjct: 2244 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2303
Query: 147 DFVAEKLDQQFRERCEELRVELLSI---HQKKVCEERKAQIAFNEELSRQKL-VEEQMFS 202
+A++ ++ +E E++ +L Q+ + ER+ Q+ + E R KL V E +
Sbjct: 2304 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2363
Query: 203 KLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQIT---SIKAQRQAT----------- 248
+ E+ + +++A+E E + T L ++T +++ QRQ +
Sbjct: 2364 QARAEEDAQRFRKQAEEIG---EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2420
Query: 249 -QLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQ------- 300
+L +E+E E+ Q+K E E +++++ QET+ + Q L E+ +Q
Sbjct: 2421 AELEREKEKLQQEAKLLQLKSE-EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2479
Query: 301 ----------------QEYRDEQDLNMKLVQRALQDL---QEEADKKKQKREDMIR-EQK 340
Q+ R+EQ + +++ Q L EEA +++ + E+ +R +Q+
Sbjct: 2480 EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE 2539
Query: 341 IYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKL- 399
+ QRR++E+ +E R+ E+ +L E+ L + +V T+ L
Sbjct: 2540 ELQQLEQQRRQQEELLAEENQRLREQ---LQLLEEQHRAAL-AHSEEVTASQVAATKTLP 2595
Query: 400 QVQEKLQREAKEQEER----AMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQI 455
++ L A E E + +K + L+E E QRLAQ
Sbjct: 2596 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL---QRLAQ---------- 2642
Query: 456 AYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEVLSTHQVLPQNI 501
+ + A +E+ R + + + L E LS + L + +
Sbjct: 2643 GHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQL 2688
Score = 48.1 bits (113), Expect = 2e-05
Identities = 80/337 (23%), Positives = 143/337 (42%), Gaps = 63/337 (18%)
Query: 149 VAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEED 208
V E+L Q+ ER ++ VE ++ E +A +A Q V ++ +L +
Sbjct: 1127 VGERLQQRHGER--DVEVERWRERVAQLLERWQAVLA-------QTDVRQRELEQLGRQL 1177
Query: 209 RLAKEKREA-----QEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNN 263
R +E + Q+ARR++E ++ L A +++ Q + Q L EE
Sbjct: 1178 RYYRESADPLGAWLQDARRRQEQIQAMPL---ADSQAVREQLRQEQALLEE--------- 1225
Query: 264 AQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQE 323
I+ E+ ++ AKQ I LQ Q E K+ + +QE
Sbjct: 1226 --IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1283
Query: 324 EADKKKQKREDMIREQKIYHKYLAQ--RREEEKAQEKEFDRILEEDKAKKLAEKDKELRL 381
D + E + Y K++++ RR EE+ +R+ E+ +A++ E+ E+
Sbjct: 1284 YVDLRTHYSE-LTTLTSQYIKFISETLRRMEEE------ERLAEQQRAEE-RERLAEVEA 1335
Query: 382 EKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQ 441
E +RQL + Q + + +REAKE ++R E+ RR+
Sbjct: 1336 ALEKQRQLAEA-----HAQAKAQAEREAKELQQRMQEE-----------------VVRRE 1373
Query: 442 RL---AQEYRKQLQMQIAYQQQSQEAEKEEKRREFEA 475
AQ+ ++ +Q ++ +QS EAE + K R+ EA
Sbjct: 1374 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1410
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 90.9 bits (224), Expect = 3e-18
Identities = 120/517 (23%), Positives = 237/517 (45%), Gaps = 51/517 (9%)
Query: 2 YSQRFGTVQREVKGPTPKVVIVRSKPPKGQGAEHHLERIRRSHQKHNAILASIKSSERDR 61
++++ ++R ++ V +R + + + ER R ++ +K++E R
Sbjct: 1722 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW-QLKANEALR 1780
Query: 62 LKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNKLRELLA----LEENEYFTEMQ 117
L+ + ++ K L + K+ + RR K E L E E + Q
Sbjct: 1781 LRLQAEEVAQQKSLAQAEAEKQKEEAE----REARRRGKAEEQAVRQRELAEQELEKQRQ 1836
Query: 118 LKKETIEEKKDRMREKTKLLKEKNEKERQ-DFVAEKLDQQFRERC------EELRVELLS 170
L + T +++ +E +L E + E+Q + E+L + RE +EL EL
Sbjct: 1837 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1896
Query: 171 IH-QKKVCEERKAQIA----FNEELSRQKL-VEEQMFSKLWEEDRLAKEKREAQEARRQK 224
+ + +V KA+ E S+Q+L E F +L EE A+ + A+EA+RQ+
Sbjct: 1897 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE--AARLRALAEEAKRQR 1954
Query: 225 ELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQET 284
+L E + + + +A ++L E+ A + E+ ++K E E + +K+ +
Sbjct: 1955 QLAEED---------AARQRAEAERVLAEKLAAIGEAT--RLKTEAEIALKEKEAENERL 2003
Query: 285 RTILQKALQERIEHIQQEYRDEQDLNMKLVQ-RALQDLQEEADKKKQKREDMIREQK-IY 342
R + + +R +Q + + D+ +L Q R D E +++K ED +R+++ +
Sbjct: 2004 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD--SELERQKGLVEDTLRQRRQVE 2061
Query: 343 HKYLAQRREEEKAQEKEFDRILEEDKAKKLAE----KDKELRLEKEARRQLVDEVMCTRK 398
+ LA + EKA + + LE + + AE ++ LE +RQL E R+
Sbjct: 2062 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE-RRR 2120
Query: 399 LQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQM-QIAY 457
+ +E++Q+ +EE A ++K E ++ L + +E R+R QE +QLQ+ Q A
Sbjct: 2121 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2180
Query: 458 QQQSQEAEK------EEKRREFEAGVAANKMCLDKVQ 488
Q++ Q EK ++K +E + + + LD+++
Sbjct: 2181 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2217
Score = 85.9 bits (211), Expect = 8e-17
Identities = 121/487 (24%), Positives = 226/487 (46%), Gaps = 49/487 (10%)
Query: 34 EHHLERIRRSHQKHNAILASIKSSERDRLKAEWD----QHNDCKILDSLVRARIKDAVQG 89
E L + R+ ++ A+ AS + + + + E + + N L S +A ++ A Q
Sbjct: 2051 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 2110
Query: 90 FIINIEERRNK-----LRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKE 144
+ EERR + +++ LA EE E + + E +E K ++ E+ + L+E+ E+E
Sbjct: 2111 QLAAEEERRRREAEERVQKSLAAEE-EAARQRKAALEEVERLKAKV-EEARRLRERAEQE 2168
Query: 145 --RQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFS 202
RQ +A++ Q+ R + EE + ++ QK+ +E + + + + Q E +
Sbjct: 2169 SARQLQLAQEAAQK-RLQAEE-KAHAFAVQQKE--QELQQTLQQEQSVLDQLRGEAEAAR 2224
Query: 203 KLWEEDRLAK--EKREAQEARRQKELMENTRLGLNAQITS-IKAQRQATQLLKEEE---A 256
+ EE A+ +REA ++RRQ E E + Q + +AQ A +L KE E A
Sbjct: 2225 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2284
Query: 257 RLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQR 316
R ++ A ++ + D ++ K +T+ QKA E+ + +E D L+
Sbjct: 2285 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2344
Query: 317 ALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKD 376
LQ L+ EA + ++R + E L R + + K RI E++A L +KD
Sbjct: 2345 ELQRLKAEATEAARQRSQVEEE-------LFSVRVQMEELSKLKARIEAENRALILRDKD 2397
Query: 377 KELRL---EKEARRQLVDEVM-CTRKLQVQEKLQREAKEQ--EERAMEQKHINESLK--- 427
R E E +Q+ +E + Q +L++ A+E ++RA+ +K + E ++
Sbjct: 2398 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2457
Query: 428 ---------ELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQS-QEAEKEEKRREFEAGV 477
EL ++KE + R QE ++Q+ Q+A + Q Q + E++R+ E
Sbjct: 2458 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2517
Query: 478 AANKMCL 484
A ++ L
Sbjct: 2518 EAERLKL 2524
Score = 85.5 bits (210), Expect = 1e-16
Identities = 110/422 (26%), Positives = 192/422 (45%), Gaps = 53/422 (12%)
Query: 96 ERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQ 155
E +L E EE E E+ E EK+ ++ E K + E+E A++L Q
Sbjct: 1482 EEEERLAEQQRAEERERLAEV----EAALEKQRQLAEAHAQAKAQAERE-----AKELQQ 1532
Query: 156 QFRE---RCEELRVELLSIHQKKVCEERKAQIAFNEEL-----SRQKLVEEQMFSKLWEE 207
+ +E R EE V+ + QK+ +E Q+ + E +RQ E+ ++ EE
Sbjct: 1533 RMQEEVVRREEAAVD--AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1590
Query: 208 DRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIK 267
R+ + + EA E RQ+ E L A+ +AQ++ Q E R V+ + +Q K
Sbjct: 1591 IRVVRLQLEATE--RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ-DESQRK 1647
Query: 268 HENEQDMLKKQKAKQETRTILQKALQE------RIEHIQQEYRDEQDLNMKLVQRALQDL 321
+ E ++ + KA+ E Q+ALQ + E ++ R + + VQ AL+
Sbjct: 1648 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1707
Query: 322 QEEADKKKQ--------KREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLA 373
Q A+ + Q K + R + H +AQ REE E+ + E ++A++ A
Sbjct: 1708 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE---AERRAQQQAEAERAREEA 1764
Query: 374 EKDKE---LRLEKEARRQLVDEVMCTRKLQVQ-------EKLQREAKEQ---EERAMEQK 420
E++ E L+ + R +L E + +K Q E+ +REA+ + EE+A+ Q+
Sbjct: 1765 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1824
Query: 421 HINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAY-QQQSQEAEKEEKRREFEAGVAA 479
+ E E + E A+++ A++ +L+ + +QQ Q E+E R + EA A
Sbjct: 1825 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1884
Query: 480 NK 481
K
Sbjct: 1885 QK 1886
Score = 79.7 bits (195), Expect = 6e-15
Identities = 115/542 (21%), Positives = 227/542 (41%), Gaps = 98/542 (18%)
Query: 33 AEHHLERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFII 92
A+ ER+RR Q + + R+KAE + + + R A++ +
Sbjct: 1629 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE--------KQRALQALEELRL 1680
Query: 93 NIEERRNKLRELLALEENEYFTEMQLKKET--------IEEKKDRMREKTKLLKEKNEKE 144
EE +LR+ E E ++Q+ ET ++ K+ EKT L+ ++E
Sbjct: 1681 QAEEAERRLRQA----EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1736
Query: 145 -------RQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVE 197
R++ Q ER E L Q K E + ++ E ++ L +
Sbjct: 1737 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1796
Query: 198 EQMFSKLWEEDRLAKEKREA------------QEARRQKELMENT---RLGLNAQITSIK 242
+ + E +R A+ + +A QE +Q++L E T RL ++ ++
Sbjct: 1797 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1856
Query: 243 AQ----RQATQLLKEEEARL-------------VESNNAQIKHENEQDMLKKQKAKQETR 285
A+ Q QLL+EE ARL +E+ A+++ E E + K +A++E+R
Sbjct: 1857 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1916
Query: 286 TILQKALQE----------------RIEHIQQEYRDEQDLNMKLVQRALQDLQE------ 323
+ +K+ Q R+ + +E + ++ L + R + +
Sbjct: 1917 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1976
Query: 324 ----EADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKA---KKLAEKD 376
EA + K + E ++E++ ++ L + E+E Q + + + KA ++LA+
Sbjct: 1977 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 2036
Query: 377 KELRLEKEARRQLVDEVMCTRKLQVQEKL-------QREAKEQEERAMEQKHINESLKEL 429
K E E ++ LV++ + R+ QV+E++ ++ A + E +E I + ++
Sbjct: 2037 KASDSELERQKGLVEDTLRQRR-QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 2095
Query: 430 --NCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKV 487
+ E+ E A RQR ++ + + + Q A +EE R+ +A + + KV
Sbjct: 2096 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2155
Query: 488 QE 489
+E
Sbjct: 2156 EE 2157
Score = 79.0 bits (193), Expect = 1e-14
Identities = 88/386 (22%), Positives = 183/386 (47%), Gaps = 21/386 (5%)
Query: 92 INIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKN-EKERQDFVA 150
I ++E+ + L L E+E F +L+++ + K D +L K + E ERQ +
Sbjct: 1991 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 2050
Query: 151 EKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSR-QKLVEEQMFSKLWEEDR 209
E +Q R+ EE+ + L + +K + + ++ EL R + E+ + SK E
Sbjct: 2051 EDTLRQRRQVEEEI-LALKASFEKAAAGKAELEL----ELGRIRSNAEDTLRSKEQAELE 2105
Query: 210 LAKEKR-EAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKH 268
A++++ A+E RR++E E + L A+ + + ++ A + ++ +A++ E+ +++
Sbjct: 2106 AARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR--RLRE 2163
Query: 269 ENEQDMLKKQKAKQETRTILQKALQ-ERIEHIQQEYRDEQDLNMKLVQR--ALQDLQEEA 325
EQ+ ++ + QE QK LQ E H + EQ+L L Q L L+ EA
Sbjct: 2164 RAEQESARQLQLAQEAA---QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2220
Query: 326 DKKKQKREDMIREQKIYHKYLAQRR----EEEKAQEKEFDRILEEDKAKKLAEKDKELRL 381
+ ++ E+ + + AQ R E E+ ++ ++ +A+ AEK ++
Sbjct: 2221 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2280
Query: 382 EKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQ 441
++ ARR ++ +K ++++ K E+ ++ + + L L + +E ++
Sbjct: 2281 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2340
Query: 442 RLAQE-YRKQLQMQIAYQQQSQEAEK 466
L +E R + + A +Q+SQ E+
Sbjct: 2341 LLDEELQRLKAEATEAARQRSQVEEE 2366
Score = 72.8 bits (177), Expect = 7e-13
Identities = 65/280 (23%), Positives = 143/280 (51%), Gaps = 29/280 (10%)
Query: 194 KLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKE 253
K + E + ++ EE+RLA+++R A+E R E+ +++ QRQ + +
Sbjct: 1472 KFISETL-RRMEEEERLAEQQR-AEERERLAEVE-----------AALEKQRQLAEAHAQ 1518
Query: 254 EEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKL 313
+A+ E +++ +++++++++A + + ++++QE ++ ++Q E ++ K
Sbjct: 1519 AKAQ-AEREAKELQQRMQEEVVRREEAAVDAQQ-QKRSIQEELQQLRQS--SEAEIQAKA 1574
Query: 314 VQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLA 373
Q E A++ + + E+ IR ++ + ++R + + + EE +A+K
Sbjct: 1575 RQA------EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1628
Query: 374 EKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEE 433
+++ RL RRQ+ DE RK Q + +L K + E A E++ ++L+EL +
Sbjct: 1629 AQEEAERL----RRQVQDESQ--RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1682
Query: 434 KENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREF 473
+E R ++ E +Q+Q+ + Q+S EAE + KR F
Sbjct: 1683 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1722
Score = 71.6 bits (174), Expect = 2e-12
Identities = 112/526 (21%), Positives = 218/526 (41%), Gaps = 92/526 (17%)
Query: 41 RRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNK 100
+RS + ++ E +LKA + N IL R KD Q F+ E+ +
Sbjct: 2359 QRSQVEEELFSVRVQMEELSKLKARIEAENRALIL------RDKDNTQRFLQEEAEKMKQ 2412
Query: 101 LRE--------------LLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQ 146
+ E L L E + + L ++ ++EK ++E T+L E ++Q
Sbjct: 2413 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2472
Query: 147 DFVAEKLDQQFRERCEELRVELLSI---HQKKVCEERKAQIAFNEELSRQKL-VEEQMFS 202
+A++ ++ +E E++ +L Q+ + ER+ Q+ + E R KL V E +
Sbjct: 2473 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2532
Query: 203 KLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQIT---SIKAQRQAT----------- 248
+ E+ + +++A+E E + T L ++T +++ QRQ +
Sbjct: 2533 QARAEEDAQRFRKQAEEIG---EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2589
Query: 249 -QLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQ------- 300
+L +E+E E+ Q+K E E +++++ QET+ + Q L E+ +Q
Sbjct: 2590 AELEREKEKLQQEAKLLQLKSE-EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2648
Query: 301 ----------------QEYRDEQDLNMKLVQRALQDL---QEEADKKKQKREDMIR-EQK 340
Q+ R+EQ + +++ Q L EEA +++ + E+ +R +Q+
Sbjct: 2649 EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE 2708
Query: 341 IYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKL- 399
+ QRR++E+ +E R+ E+ +L E+ L + +V T+ L
Sbjct: 2709 ELQQLEQQRRQQEELLAEENQRLREQ---LQLLEEQHRAAL-AHSEEVTASQVAATKTLP 2764
Query: 400 QVQEKLQREAKEQEER----AMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQI 455
++ L A E E + +K + L+E E QRLAQ
Sbjct: 2765 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL---QRLAQ---------- 2811
Query: 456 AYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEVLSTHQVLPQNI 501
+ + A +E+ R + + + L E LS + L + +
Sbjct: 2812 GHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQL 2857
Score = 48.1 bits (113), Expect = 2e-05
Identities = 80/337 (23%), Positives = 143/337 (42%), Gaps = 63/337 (18%)
Query: 149 VAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEED 208
V E+L Q+ ER ++ VE ++ E +A +A Q V ++ +L +
Sbjct: 1296 VGERLQQRHGER--DVEVERWRERVAQLLERWQAVLA-------QTDVRQRELEQLGRQL 1346
Query: 209 RLAKEKREA-----QEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNN 263
R +E + Q+ARR++E ++ L A +++ Q + Q L EE
Sbjct: 1347 RYYRESADPLGAWLQDARRRQEQIQAMPL---ADSQAVREQLRQEQALLEE--------- 1394
Query: 264 AQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQE 323
I+ E+ ++ AKQ I LQ Q E K+ + +QE
Sbjct: 1395 --IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1452
Query: 324 EADKKKQKREDMIREQKIYHKYLAQ--RREEEKAQEKEFDRILEEDKAKKLAEKDKELRL 381
D + E + Y K++++ RR EE+ +R+ E+ +A++ E+ E+
Sbjct: 1453 YVDLRTHYSE-LTTLTSQYIKFISETLRRMEEE------ERLAEQQRAEE-RERLAEVEA 1504
Query: 382 EKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQ 441
E +RQL + Q + + +REAKE ++R E+ RR+
Sbjct: 1505 ALEKQRQLAEA-----HAQAKAQAEREAKELQQRMQEE-----------------VVRRE 1542
Query: 442 RL---AQEYRKQLQMQIAYQQQSQEAEKEEKRREFEA 475
AQ+ ++ +Q ++ +QS EAE + K R+ EA
Sbjct: 1543 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1579
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 90.9 bits (224), Expect = 3e-18
Identities = 120/517 (23%), Positives = 237/517 (45%), Gaps = 51/517 (9%)
Query: 2 YSQRFGTVQREVKGPTPKVVIVRSKPPKGQGAEHHLERIRRSHQKHNAILASIKSSERDR 61
++++ ++R ++ V +R + + + ER R ++ +K++E R
Sbjct: 1563 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW-QLKANEALR 1621
Query: 62 LKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNKLRELLA----LEENEYFTEMQ 117
L+ + ++ K L + K+ + RR K E L E E + Q
Sbjct: 1622 LRLQAEEVAQQKSLAQAEAEKQKEEAE----REARRRGKAEEQAVRQRELAEQELEKQRQ 1677
Query: 118 LKKETIEEKKDRMREKTKLLKEKNEKERQ-DFVAEKLDQQFRERC------EELRVELLS 170
L + T +++ +E +L E + E+Q + E+L + RE +EL EL
Sbjct: 1678 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1737
Query: 171 IH-QKKVCEERKAQIA----FNEELSRQKL-VEEQMFSKLWEEDRLAKEKREAQEARRQK 224
+ + +V KA+ E S+Q+L E F +L EE A+ + A+EA+RQ+
Sbjct: 1738 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE--AARLRALAEEAKRQR 1795
Query: 225 ELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQET 284
+L E + + + +A ++L E+ A + E+ ++K E E + +K+ +
Sbjct: 1796 QLAEED---------AARQRAEAERVLAEKLAAIGEAT--RLKTEAEIALKEKEAENERL 1844
Query: 285 RTILQKALQERIEHIQQEYRDEQDLNMKLVQ-RALQDLQEEADKKKQKREDMIREQK-IY 342
R + + +R +Q + + D+ +L Q R D E +++K ED +R+++ +
Sbjct: 1845 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD--SELERQKGLVEDTLRQRRQVE 1902
Query: 343 HKYLAQRREEEKAQEKEFDRILEEDKAKKLAE----KDKELRLEKEARRQLVDEVMCTRK 398
+ LA + EKA + + LE + + AE ++ LE +RQL E R+
Sbjct: 1903 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE-RRR 1961
Query: 399 LQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQM-QIAY 457
+ +E++Q+ +EE A ++K E ++ L + +E R+R QE +QLQ+ Q A
Sbjct: 1962 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2021
Query: 458 QQQSQEAEK------EEKRREFEAGVAANKMCLDKVQ 488
Q++ Q EK ++K +E + + + LD+++
Sbjct: 2022 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2058
Score = 85.9 bits (211), Expect = 8e-17
Identities = 121/487 (24%), Positives = 226/487 (46%), Gaps = 49/487 (10%)
Query: 34 EHHLERIRRSHQKHNAILASIKSSERDRLKAEWD----QHNDCKILDSLVRARIKDAVQG 89
E L + R+ ++ A+ AS + + + + E + + N L S +A ++ A Q
Sbjct: 1892 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1951
Query: 90 FIINIEERRNK-----LRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKE 144
+ EERR + +++ LA EE E + + E +E K ++ E+ + L+E+ E+E
Sbjct: 1952 QLAAEEERRRREAEERVQKSLAAEE-EAARQRKAALEEVERLKAKV-EEARRLRERAEQE 2009
Query: 145 --RQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFS 202
RQ +A++ Q+ R + EE + ++ QK+ +E + + + + Q E +
Sbjct: 2010 SARQLQLAQEAAQK-RLQAEE-KAHAFAVQQKE--QELQQTLQQEQSVLDQLRGEAEAAR 2065
Query: 203 KLWEEDRLAK--EKREAQEARRQKELMENTRLGLNAQITS-IKAQRQATQLLKEEE---A 256
+ EE A+ +REA ++RRQ E E + Q + +AQ A +L KE E A
Sbjct: 2066 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2125
Query: 257 RLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQR 316
R ++ A ++ + D ++ K +T+ QKA E+ + +E D L+
Sbjct: 2126 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2185
Query: 317 ALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKD 376
LQ L+ EA + ++R + E L R + + K RI E++A L +KD
Sbjct: 2186 ELQRLKAEATEAARQRSQVEEE-------LFSVRVQMEELSKLKARIEAENRALILRDKD 2238
Query: 377 KELRL---EKEARRQLVDEVM-CTRKLQVQEKLQREAKEQ--EERAMEQKHINESLK--- 427
R E E +Q+ +E + Q +L++ A+E ++RA+ +K + E ++
Sbjct: 2239 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2298
Query: 428 ---------ELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQS-QEAEKEEKRREFEAGV 477
EL ++KE + R QE ++Q+ Q+A + Q Q + E++R+ E
Sbjct: 2299 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2358
Query: 478 AANKMCL 484
A ++ L
Sbjct: 2359 EAERLKL 2365
Score = 85.5 bits (210), Expect = 1e-16
Identities = 110/422 (26%), Positives = 192/422 (45%), Gaps = 53/422 (12%)
Query: 96 ERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQ 155
E +L E EE E E+ E EK+ ++ E K + E+E A++L Q
Sbjct: 1323 EEEERLAEQQRAEERERLAEV----EAALEKQRQLAEAHAQAKAQAERE-----AKELQQ 1373
Query: 156 QFRE---RCEELRVELLSIHQKKVCEERKAQIAFNEEL-----SRQKLVEEQMFSKLWEE 207
+ +E R EE V+ + QK+ +E Q+ + E +RQ E+ ++ EE
Sbjct: 1374 RMQEEVVRREEAAVD--AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1431
Query: 208 DRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIK 267
R+ + + EA E RQ+ E L A+ +AQ++ Q E R V+ + +Q K
Sbjct: 1432 IRVVRLQLEATE--RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ-DESQRK 1488
Query: 268 HENEQDMLKKQKAKQETRTILQKALQE------RIEHIQQEYRDEQDLNMKLVQRALQDL 321
+ E ++ + KA+ E Q+ALQ + E ++ R + + VQ AL+
Sbjct: 1489 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1548
Query: 322 QEEADKKKQ--------KREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLA 373
Q A+ + Q K + R + H +AQ REE E+ + E ++A++ A
Sbjct: 1549 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE---AERRAQQQAEAERAREEA 1605
Query: 374 EKDKE---LRLEKEARRQLVDEVMCTRKLQVQ-------EKLQREAKEQ---EERAMEQK 420
E++ E L+ + R +L E + +K Q E+ +REA+ + EE+A+ Q+
Sbjct: 1606 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1665
Query: 421 HINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAY-QQQSQEAEKEEKRREFEAGVAA 479
+ E E + E A+++ A++ +L+ + +QQ Q E+E R + EA A
Sbjct: 1666 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1725
Query: 480 NK 481
K
Sbjct: 1726 QK 1727
Score = 79.7 bits (195), Expect = 6e-15
Identities = 115/542 (21%), Positives = 227/542 (41%), Gaps = 98/542 (18%)
Query: 33 AEHHLERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFII 92
A+ ER+RR Q + + R+KAE + + + R A++ +
Sbjct: 1470 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE--------KQRALQALEELRL 1521
Query: 93 NIEERRNKLRELLALEENEYFTEMQLKKET--------IEEKKDRMREKTKLLKEKNEKE 144
EE +LR+ E E ++Q+ ET ++ K+ EKT L+ ++E
Sbjct: 1522 QAEEAERRLRQA----EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1577
Query: 145 -------RQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVE 197
R++ Q ER E L Q K E + ++ E ++ L +
Sbjct: 1578 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1637
Query: 198 EQMFSKLWEEDRLAKEKREA------------QEARRQKELMENT---RLGLNAQITSIK 242
+ + E +R A+ + +A QE +Q++L E T RL ++ ++
Sbjct: 1638 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1697
Query: 243 AQ----RQATQLLKEEEARL-------------VESNNAQIKHENEQDMLKKQKAKQETR 285
A+ Q QLL+EE ARL +E+ A+++ E E + K +A++E+R
Sbjct: 1698 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1757
Query: 286 TILQKALQE----------------RIEHIQQEYRDEQDLNMKLVQRALQDLQE------ 323
+ +K+ Q R+ + +E + ++ L + R + +
Sbjct: 1758 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1817
Query: 324 ----EADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKA---KKLAEKD 376
EA + K + E ++E++ ++ L + E+E Q + + + KA ++LA+
Sbjct: 1818 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1877
Query: 377 KELRLEKEARRQLVDEVMCTRKLQVQEKL-------QREAKEQEERAMEQKHINESLKEL 429
K E E ++ LV++ + R+ QV+E++ ++ A + E +E I + ++
Sbjct: 1878 KASDSELERQKGLVEDTLRQRR-QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 1936
Query: 430 --NCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKV 487
+ E+ E A RQR ++ + + + Q A +EE R+ +A + + KV
Sbjct: 1937 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 1996
Query: 488 QE 489
+E
Sbjct: 1997 EE 1998
Score = 79.0 bits (193), Expect = 1e-14
Identities = 88/386 (22%), Positives = 183/386 (47%), Gaps = 21/386 (5%)
Query: 92 INIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKN-EKERQDFVA 150
I ++E+ + L L E+E F +L+++ + K D +L K + E ERQ +
Sbjct: 1832 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1891
Query: 151 EKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSR-QKLVEEQMFSKLWEEDR 209
E +Q R+ EE+ + L + +K + + ++ EL R + E+ + SK E
Sbjct: 1892 EDTLRQRRQVEEEI-LALKASFEKAAAGKAELEL----ELGRIRSNAEDTLRSKEQAELE 1946
Query: 210 LAKEKR-EAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKH 268
A++++ A+E RR++E E + L A+ + + ++ A + ++ +A++ E+ +++
Sbjct: 1947 AARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR--RLRE 2004
Query: 269 ENEQDMLKKQKAKQETRTILQKALQ-ERIEHIQQEYRDEQDLNMKLVQR--ALQDLQEEA 325
EQ+ ++ + QE QK LQ E H + EQ+L L Q L L+ EA
Sbjct: 2005 RAEQESARQLQLAQEAA---QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2061
Query: 326 DKKKQKREDMIREQKIYHKYLAQRR----EEEKAQEKEFDRILEEDKAKKLAEKDKELRL 381
+ ++ E+ + + AQ R E E+ ++ ++ +A+ AEK ++
Sbjct: 2062 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2121
Query: 382 EKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQ 441
++ ARR ++ +K ++++ K E+ ++ + + L L + +E ++
Sbjct: 2122 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2181
Query: 442 RLAQE-YRKQLQMQIAYQQQSQEAEK 466
L +E R + + A +Q+SQ E+
Sbjct: 2182 LLDEELQRLKAEATEAARQRSQVEEE 2207
Score = 72.8 bits (177), Expect = 7e-13
Identities = 65/280 (23%), Positives = 143/280 (51%), Gaps = 29/280 (10%)
Query: 194 KLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKE 253
K + E + ++ EE+RLA+++R A+E R E+ +++ QRQ + +
Sbjct: 1313 KFISETL-RRMEEEERLAEQQR-AEERERLAEVE-----------AALEKQRQLAEAHAQ 1359
Query: 254 EEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKL 313
+A+ E +++ +++++++++A + + ++++QE ++ ++Q E ++ K
Sbjct: 1360 AKAQ-AEREAKELQQRMQEEVVRREEAAVDAQQ-QKRSIQEELQQLRQS--SEAEIQAKA 1415
Query: 314 VQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLA 373
Q E A++ + + E+ IR ++ + ++R + + + EE +A+K
Sbjct: 1416 RQA------EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1469
Query: 374 EKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEE 433
+++ RL RRQ+ DE RK Q + +L K + E A E++ ++L+EL +
Sbjct: 1470 AQEEAERL----RRQVQDESQ--RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1523
Query: 434 KENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREF 473
+E R ++ E +Q+Q+ + Q+S EAE + KR F
Sbjct: 1524 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1563
Score = 71.6 bits (174), Expect = 2e-12
Identities = 112/526 (21%), Positives = 218/526 (41%), Gaps = 92/526 (17%)
Query: 41 RRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNK 100
+RS + ++ E +LKA + N IL R KD Q F+ E+ +
Sbjct: 2200 QRSQVEEELFSVRVQMEELSKLKARIEAENRALIL------RDKDNTQRFLQEEAEKMKQ 2253
Query: 101 LRE--------------LLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQ 146
+ E L L E + + L ++ ++EK ++E T+L E ++Q
Sbjct: 2254 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2313
Query: 147 DFVAEKLDQQFRERCEELRVELLSI---HQKKVCEERKAQIAFNEELSRQKL-VEEQMFS 202
+A++ ++ +E E++ +L Q+ + ER+ Q+ + E R KL V E +
Sbjct: 2314 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2373
Query: 203 KLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQIT---SIKAQRQAT----------- 248
+ E+ + +++A+E E + T L ++T +++ QRQ +
Sbjct: 2374 QARAEEDAQRFRKQAEEIG---EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2430
Query: 249 -QLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQ------- 300
+L +E+E E+ Q+K E E +++++ QET+ + Q L E+ +Q
Sbjct: 2431 AELEREKEKLQQEAKLLQLKSE-EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2489
Query: 301 ----------------QEYRDEQDLNMKLVQRALQDL---QEEADKKKQKREDMIR-EQK 340
Q+ R+EQ + +++ Q L EEA +++ + E+ +R +Q+
Sbjct: 2490 EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE 2549
Query: 341 IYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKL- 399
+ QRR++E+ +E R+ E+ +L E+ L + +V T+ L
Sbjct: 2550 ELQQLEQQRRQQEELLAEENQRLREQ---LQLLEEQHRAAL-AHSEEVTASQVAATKTLP 2605
Query: 400 QVQEKLQREAKEQEER----AMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQI 455
++ L A E E + +K + L+E E QRLAQ
Sbjct: 2606 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL---QRLAQ---------- 2652
Query: 456 AYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEVLSTHQVLPQNI 501
+ + A +E+ R + + + L E LS + L + +
Sbjct: 2653 GHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQL 2698
Score = 48.1 bits (113), Expect = 2e-05
Identities = 80/337 (23%), Positives = 143/337 (42%), Gaps = 63/337 (18%)
Query: 149 VAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEED 208
V E+L Q+ ER ++ VE ++ E +A +A Q V ++ +L +
Sbjct: 1137 VGERLQQRHGER--DVEVERWRERVAQLLERWQAVLA-------QTDVRQRELEQLGRQL 1187
Query: 209 RLAKEKREA-----QEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNN 263
R +E + Q+ARR++E ++ L A +++ Q + Q L EE
Sbjct: 1188 RYYRESADPLGAWLQDARRRQEQIQAMPL---ADSQAVREQLRQEQALLEE--------- 1235
Query: 264 AQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQE 323
I+ E+ ++ AKQ I LQ Q E K+ + +QE
Sbjct: 1236 --IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1293
Query: 324 EADKKKQKREDMIREQKIYHKYLAQ--RREEEKAQEKEFDRILEEDKAKKLAEKDKELRL 381
D + E + Y K++++ RR EE+ +R+ E+ +A++ E+ E+
Sbjct: 1294 YVDLRTHYSE-LTTLTSQYIKFISETLRRMEEE------ERLAEQQRAEE-RERLAEVEA 1345
Query: 382 EKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQ 441
E +RQL + Q + + +REAKE ++R E+ RR+
Sbjct: 1346 ALEKQRQLAEA-----HAQAKAQAEREAKELQQRMQEE-----------------VVRRE 1383
Query: 442 RL---AQEYRKQLQMQIAYQQQSQEAEKEEKRREFEA 475
AQ+ ++ +Q ++ +QS EAE + K R+ EA
Sbjct: 1384 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1420
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 90.9 bits (224), Expect = 3e-18
Identities = 120/517 (23%), Positives = 237/517 (45%), Gaps = 51/517 (9%)
Query: 2 YSQRFGTVQREVKGPTPKVVIVRSKPPKGQGAEHHLERIRRSHQKHNAILASIKSSERDR 61
++++ ++R ++ V +R + + + ER R ++ +K++E R
Sbjct: 1571 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW-QLKANEALR 1629
Query: 62 LKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNKLRELLA----LEENEYFTEMQ 117
L+ + ++ K L + K+ + RR K E L E E + Q
Sbjct: 1630 LRLQAEEVAQQKSLAQAEAEKQKEEAE----REARRRGKAEEQAVRQRELAEQELEKQRQ 1685
Query: 118 LKKETIEEKKDRMREKTKLLKEKNEKERQ-DFVAEKLDQQFRERC------EELRVELLS 170
L + T +++ +E +L E + E+Q + E+L + RE +EL EL
Sbjct: 1686 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1745
Query: 171 IH-QKKVCEERKAQIA----FNEELSRQKL-VEEQMFSKLWEEDRLAKEKREAQEARRQK 224
+ + +V KA+ E S+Q+L E F +L EE A+ + A+EA+RQ+
Sbjct: 1746 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE--AARLRALAEEAKRQR 1803
Query: 225 ELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQET 284
+L E + + + +A ++L E+ A + E+ ++K E E + +K+ +
Sbjct: 1804 QLAEED---------AARQRAEAERVLAEKLAAIGEAT--RLKTEAEIALKEKEAENERL 1852
Query: 285 RTILQKALQERIEHIQQEYRDEQDLNMKLVQ-RALQDLQEEADKKKQKREDMIREQK-IY 342
R + + +R +Q + + D+ +L Q R D E +++K ED +R+++ +
Sbjct: 1853 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD--SELERQKGLVEDTLRQRRQVE 1910
Query: 343 HKYLAQRREEEKAQEKEFDRILEEDKAKKLAE----KDKELRLEKEARRQLVDEVMCTRK 398
+ LA + EKA + + LE + + AE ++ LE +RQL E R+
Sbjct: 1911 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE-RRR 1969
Query: 399 LQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQM-QIAY 457
+ +E++Q+ +EE A ++K E ++ L + +E R+R QE +QLQ+ Q A
Sbjct: 1970 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2029
Query: 458 QQQSQEAEK------EEKRREFEAGVAANKMCLDKVQ 488
Q++ Q EK ++K +E + + + LD+++
Sbjct: 2030 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2066
Score = 85.9 bits (211), Expect = 8e-17
Identities = 121/487 (24%), Positives = 226/487 (46%), Gaps = 49/487 (10%)
Query: 34 EHHLERIRRSHQKHNAILASIKSSERDRLKAEWD----QHNDCKILDSLVRARIKDAVQG 89
E L + R+ ++ A+ AS + + + + E + + N L S +A ++ A Q
Sbjct: 1900 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1959
Query: 90 FIINIEERRNK-----LRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKE 144
+ EERR + +++ LA EE E + + E +E K ++ E+ + L+E+ E+E
Sbjct: 1960 QLAAEEERRRREAEERVQKSLAAEE-EAARQRKAALEEVERLKAKV-EEARRLRERAEQE 2017
Query: 145 --RQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFS 202
RQ +A++ Q+ R + EE + ++ QK+ +E + + + + Q E +
Sbjct: 2018 SARQLQLAQEAAQK-RLQAEE-KAHAFAVQQKE--QELQQTLQQEQSVLDQLRGEAEAAR 2073
Query: 203 KLWEEDRLAK--EKREAQEARRQKELMENTRLGLNAQITS-IKAQRQATQLLKEEE---A 256
+ EE A+ +REA ++RRQ E E + Q + +AQ A +L KE E A
Sbjct: 2074 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2133
Query: 257 RLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQR 316
R ++ A ++ + D ++ K +T+ QKA E+ + +E D L+
Sbjct: 2134 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2193
Query: 317 ALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKD 376
LQ L+ EA + ++R + E L R + + K RI E++A L +KD
Sbjct: 2194 ELQRLKAEATEAARQRSQVEEE-------LFSVRVQMEELSKLKARIEAENRALILRDKD 2246
Query: 377 KELRL---EKEARRQLVDEVM-CTRKLQVQEKLQREAKEQ--EERAMEQKHINESLK--- 427
R E E +Q+ +E + Q +L++ A+E ++RA+ +K + E ++
Sbjct: 2247 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2306
Query: 428 ---------ELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQS-QEAEKEEKRREFEAGV 477
EL ++KE + R QE ++Q+ Q+A + Q Q + E++R+ E
Sbjct: 2307 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2366
Query: 478 AANKMCL 484
A ++ L
Sbjct: 2367 EAERLKL 2373
Score = 85.5 bits (210), Expect = 1e-16
Identities = 110/422 (26%), Positives = 192/422 (45%), Gaps = 53/422 (12%)
Query: 96 ERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQ 155
E +L E EE E E+ E EK+ ++ E K + E+E A++L Q
Sbjct: 1331 EEEERLAEQQRAEERERLAEV----EAALEKQRQLAEAHAQAKAQAERE-----AKELQQ 1381
Query: 156 QFRE---RCEELRVELLSIHQKKVCEERKAQIAFNEEL-----SRQKLVEEQMFSKLWEE 207
+ +E R EE V+ + QK+ +E Q+ + E +RQ E+ ++ EE
Sbjct: 1382 RMQEEVVRREEAAVD--AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1439
Query: 208 DRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIK 267
R+ + + EA E RQ+ E L A+ +AQ++ Q E R V+ + +Q K
Sbjct: 1440 IRVVRLQLEATE--RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ-DESQRK 1496
Query: 268 HENEQDMLKKQKAKQETRTILQKALQE------RIEHIQQEYRDEQDLNMKLVQRALQDL 321
+ E ++ + KA+ E Q+ALQ + E ++ R + + VQ AL+
Sbjct: 1497 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1556
Query: 322 QEEADKKKQ--------KREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLA 373
Q A+ + Q K + R + H +AQ REE E+ + E ++A++ A
Sbjct: 1557 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE---AERRAQQQAEAERAREEA 1613
Query: 374 EKDKE---LRLEKEARRQLVDEVMCTRKLQVQ-------EKLQREAKEQ---EERAMEQK 420
E++ E L+ + R +L E + +K Q E+ +REA+ + EE+A+ Q+
Sbjct: 1614 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1673
Query: 421 HINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAY-QQQSQEAEKEEKRREFEAGVAA 479
+ E E + E A+++ A++ +L+ + +QQ Q E+E R + EA A
Sbjct: 1674 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1733
Query: 480 NK 481
K
Sbjct: 1734 QK 1735
Score = 79.7 bits (195), Expect = 6e-15
Identities = 115/542 (21%), Positives = 227/542 (41%), Gaps = 98/542 (18%)
Query: 33 AEHHLERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFII 92
A+ ER+RR Q + + R+KAE + + + R A++ +
Sbjct: 1478 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE--------KQRALQALEELRL 1529
Query: 93 NIEERRNKLRELLALEENEYFTEMQLKKET--------IEEKKDRMREKTKLLKEKNEKE 144
EE +LR+ E E ++Q+ ET ++ K+ EKT L+ ++E
Sbjct: 1530 QAEEAERRLRQA----EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1585
Query: 145 -------RQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVE 197
R++ Q ER E L Q K E + ++ E ++ L +
Sbjct: 1586 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1645
Query: 198 EQMFSKLWEEDRLAKEKREA------------QEARRQKELMENT---RLGLNAQITSIK 242
+ + E +R A+ + +A QE +Q++L E T RL ++ ++
Sbjct: 1646 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1705
Query: 243 AQ----RQATQLLKEEEARL-------------VESNNAQIKHENEQDMLKKQKAKQETR 285
A+ Q QLL+EE ARL +E+ A+++ E E + K +A++E+R
Sbjct: 1706 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1765
Query: 286 TILQKALQE----------------RIEHIQQEYRDEQDLNMKLVQRALQDLQE------ 323
+ +K+ Q R+ + +E + ++ L + R + +
Sbjct: 1766 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1825
Query: 324 ----EADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKA---KKLAEKD 376
EA + K + E ++E++ ++ L + E+E Q + + + KA ++LA+
Sbjct: 1826 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1885
Query: 377 KELRLEKEARRQLVDEVMCTRKLQVQEKL-------QREAKEQEERAMEQKHINESLKEL 429
K E E ++ LV++ + R+ QV+E++ ++ A + E +E I + ++
Sbjct: 1886 KASDSELERQKGLVEDTLRQRR-QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 1944
Query: 430 --NCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKV 487
+ E+ E A RQR ++ + + + Q A +EE R+ +A + + KV
Sbjct: 1945 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2004
Query: 488 QE 489
+E
Sbjct: 2005 EE 2006
Score = 79.0 bits (193), Expect = 1e-14
Identities = 88/386 (22%), Positives = 183/386 (47%), Gaps = 21/386 (5%)
Query: 92 INIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKN-EKERQDFVA 150
I ++E+ + L L E+E F +L+++ + K D +L K + E ERQ +
Sbjct: 1840 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1899
Query: 151 EKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSR-QKLVEEQMFSKLWEEDR 209
E +Q R+ EE+ + L + +K + + ++ EL R + E+ + SK E
Sbjct: 1900 EDTLRQRRQVEEEI-LALKASFEKAAAGKAELEL----ELGRIRSNAEDTLRSKEQAELE 1954
Query: 210 LAKEKR-EAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKH 268
A++++ A+E RR++E E + L A+ + + ++ A + ++ +A++ E+ +++
Sbjct: 1955 AARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR--RLRE 2012
Query: 269 ENEQDMLKKQKAKQETRTILQKALQ-ERIEHIQQEYRDEQDLNMKLVQR--ALQDLQEEA 325
EQ+ ++ + QE QK LQ E H + EQ+L L Q L L+ EA
Sbjct: 2013 RAEQESARQLQLAQEAA---QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2069
Query: 326 DKKKQKREDMIREQKIYHKYLAQRR----EEEKAQEKEFDRILEEDKAKKLAEKDKELRL 381
+ ++ E+ + + AQ R E E+ ++ ++ +A+ AEK ++
Sbjct: 2070 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2129
Query: 382 EKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQ 441
++ ARR ++ +K ++++ K E+ ++ + + L L + +E ++
Sbjct: 2130 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2189
Query: 442 RLAQE-YRKQLQMQIAYQQQSQEAEK 466
L +E R + + A +Q+SQ E+
Sbjct: 2190 LLDEELQRLKAEATEAARQRSQVEEE 2215
Score = 72.8 bits (177), Expect = 7e-13
Identities = 65/280 (23%), Positives = 143/280 (51%), Gaps = 29/280 (10%)
Query: 194 KLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKE 253
K + E + ++ EE+RLA+++R A+E R E+ +++ QRQ + +
Sbjct: 1321 KFISETL-RRMEEEERLAEQQR-AEERERLAEVE-----------AALEKQRQLAEAHAQ 1367
Query: 254 EEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKL 313
+A+ E +++ +++++++++A + + ++++QE ++ ++Q E ++ K
Sbjct: 1368 AKAQ-AEREAKELQQRMQEEVVRREEAAVDAQQ-QKRSIQEELQQLRQS--SEAEIQAKA 1423
Query: 314 VQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLA 373
Q E A++ + + E+ IR ++ + ++R + + + EE +A+K
Sbjct: 1424 RQA------EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1477
Query: 374 EKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEE 433
+++ RL RRQ+ DE RK Q + +L K + E A E++ ++L+EL +
Sbjct: 1478 AQEEAERL----RRQVQDESQ--RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1531
Query: 434 KENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREF 473
+E R ++ E +Q+Q+ + Q+S EAE + KR F
Sbjct: 1532 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1571
Score = 71.6 bits (174), Expect = 2e-12
Identities = 112/526 (21%), Positives = 218/526 (41%), Gaps = 92/526 (17%)
Query: 41 RRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNK 100
+RS + ++ E +LKA + N IL R KD Q F+ E+ +
Sbjct: 2208 QRSQVEEELFSVRVQMEELSKLKARIEAENRALIL------RDKDNTQRFLQEEAEKMKQ 2261
Query: 101 LRE--------------LLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQ 146
+ E L L E + + L ++ ++EK ++E T+L E ++Q
Sbjct: 2262 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2321
Query: 147 DFVAEKLDQQFRERCEELRVELLSI---HQKKVCEERKAQIAFNEELSRQKL-VEEQMFS 202
+A++ ++ +E E++ +L Q+ + ER+ Q+ + E R KL V E +
Sbjct: 2322 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2381
Query: 203 KLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQIT---SIKAQRQAT----------- 248
+ E+ + +++A+E E + T L ++T +++ QRQ +
Sbjct: 2382 QARAEEDAQRFRKQAEEIG---EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2438
Query: 249 -QLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQ------- 300
+L +E+E E+ Q+K E E +++++ QET+ + Q L E+ +Q
Sbjct: 2439 AELEREKEKLQQEAKLLQLKSE-EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2497
Query: 301 ----------------QEYRDEQDLNMKLVQRALQDL---QEEADKKKQKREDMIR-EQK 340
Q+ R+EQ + +++ Q L EEA +++ + E+ +R +Q+
Sbjct: 2498 EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE 2557
Query: 341 IYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKL- 399
+ QRR++E+ +E R+ E+ +L E+ L + +V T+ L
Sbjct: 2558 ELQQLEQQRRQQEELLAEENQRLREQ---LQLLEEQHRAAL-AHSEEVTASQVAATKTLP 2613
Query: 400 QVQEKLQREAKEQEER----AMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQI 455
++ L A E E + +K + L+E E QRLAQ
Sbjct: 2614 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL---QRLAQ---------- 2660
Query: 456 AYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEVLSTHQVLPQNI 501
+ + A +E+ R + + + L E LS + L + +
Sbjct: 2661 GHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQL 2706
Score = 48.1 bits (113), Expect = 2e-05
Identities = 80/337 (23%), Positives = 143/337 (42%), Gaps = 63/337 (18%)
Query: 149 VAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEED 208
V E+L Q+ ER ++ VE ++ E +A +A Q V ++ +L +
Sbjct: 1145 VGERLQQRHGER--DVEVERWRERVAQLLERWQAVLA-------QTDVRQRELEQLGRQL 1195
Query: 209 RLAKEKREA-----QEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNN 263
R +E + Q+ARR++E ++ L A +++ Q + Q L EE
Sbjct: 1196 RYYRESADPLGAWLQDARRRQEQIQAMPL---ADSQAVREQLRQEQALLEE--------- 1243
Query: 264 AQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQE 323
I+ E+ ++ AKQ I LQ Q E K+ + +QE
Sbjct: 1244 --IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1301
Query: 324 EADKKKQKREDMIREQKIYHKYLAQ--RREEEKAQEKEFDRILEEDKAKKLAEKDKELRL 381
D + E + Y K++++ RR EE+ +R+ E+ +A++ E+ E+
Sbjct: 1302 YVDLRTHYSE-LTTLTSQYIKFISETLRRMEEE------ERLAEQQRAEE-RERLAEVEA 1353
Query: 382 EKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQ 441
E +RQL + Q + + +REAKE ++R E+ RR+
Sbjct: 1354 ALEKQRQLAEA-----HAQAKAQAEREAKELQQRMQEE-----------------VVRRE 1391
Query: 442 RL---AQEYRKQLQMQIAYQQQSQEAEKEEKRREFEA 475
AQ+ ++ +Q ++ +QS EAE + K R+ EA
Sbjct: 1392 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1428
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 90.9 bits (224), Expect = 3e-18
Identities = 120/517 (23%), Positives = 237/517 (45%), Gaps = 51/517 (9%)
Query: 2 YSQRFGTVQREVKGPTPKVVIVRSKPPKGQGAEHHLERIRRSHQKHNAILASIKSSERDR 61
++++ ++R ++ V +R + + + ER R ++ +K++E R
Sbjct: 1612 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW-QLKANEALR 1670
Query: 62 LKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNKLRELLA----LEENEYFTEMQ 117
L+ + ++ K L + K+ + RR K E L E E + Q
Sbjct: 1671 LRLQAEEVAQQKSLAQAEAEKQKEEAE----REARRRGKAEEQAVRQRELAEQELEKQRQ 1726
Query: 118 LKKETIEEKKDRMREKTKLLKEKNEKERQ-DFVAEKLDQQFRERC------EELRVELLS 170
L + T +++ +E +L E + E+Q + E+L + RE +EL EL
Sbjct: 1727 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1786
Query: 171 IH-QKKVCEERKAQIA----FNEELSRQKL-VEEQMFSKLWEEDRLAKEKREAQEARRQK 224
+ + +V KA+ E S+Q+L E F +L EE A+ + A+EA+RQ+
Sbjct: 1787 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE--AARLRALAEEAKRQR 1844
Query: 225 ELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQET 284
+L E + + + +A ++L E+ A + E+ ++K E E + +K+ +
Sbjct: 1845 QLAEED---------AARQRAEAERVLAEKLAAIGEAT--RLKTEAEIALKEKEAENERL 1893
Query: 285 RTILQKALQERIEHIQQEYRDEQDLNMKLVQ-RALQDLQEEADKKKQKREDMIREQK-IY 342
R + + +R +Q + + D+ +L Q R D E +++K ED +R+++ +
Sbjct: 1894 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD--SELERQKGLVEDTLRQRRQVE 1951
Query: 343 HKYLAQRREEEKAQEKEFDRILEEDKAKKLAE----KDKELRLEKEARRQLVDEVMCTRK 398
+ LA + EKA + + LE + + AE ++ LE +RQL E R+
Sbjct: 1952 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE-RRR 2010
Query: 399 LQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQM-QIAY 457
+ +E++Q+ +EE A ++K E ++ L + +E R+R QE +QLQ+ Q A
Sbjct: 2011 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2070
Query: 458 QQQSQEAEK------EEKRREFEAGVAANKMCLDKVQ 488
Q++ Q EK ++K +E + + + LD+++
Sbjct: 2071 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2107
Score = 85.9 bits (211), Expect = 8e-17
Identities = 121/487 (24%), Positives = 226/487 (46%), Gaps = 49/487 (10%)
Query: 34 EHHLERIRRSHQKHNAILASIKSSERDRLKAEWD----QHNDCKILDSLVRARIKDAVQG 89
E L + R+ ++ A+ AS + + + + E + + N L S +A ++ A Q
Sbjct: 1941 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 2000
Query: 90 FIINIEERRNK-----LRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKE 144
+ EERR + +++ LA EE E + + E +E K ++ E+ + L+E+ E+E
Sbjct: 2001 QLAAEEERRRREAEERVQKSLAAEE-EAARQRKAALEEVERLKAKV-EEARRLRERAEQE 2058
Query: 145 --RQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFS 202
RQ +A++ Q+ R + EE + ++ QK+ +E + + + + Q E +
Sbjct: 2059 SARQLQLAQEAAQK-RLQAEE-KAHAFAVQQKE--QELQQTLQQEQSVLDQLRGEAEAAR 2114
Query: 203 KLWEEDRLAK--EKREAQEARRQKELMENTRLGLNAQITS-IKAQRQATQLLKEEE---A 256
+ EE A+ +REA ++RRQ E E + Q + +AQ A +L KE E A
Sbjct: 2115 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2174
Query: 257 RLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQR 316
R ++ A ++ + D ++ K +T+ QKA E+ + +E D L+
Sbjct: 2175 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2234
Query: 317 ALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKD 376
LQ L+ EA + ++R + E L R + + K RI E++A L +KD
Sbjct: 2235 ELQRLKAEATEAARQRSQVEEE-------LFSVRVQMEELSKLKARIEAENRALILRDKD 2287
Query: 377 KELRL---EKEARRQLVDEVM-CTRKLQVQEKLQREAKEQ--EERAMEQKHINESLK--- 427
R E E +Q+ +E + Q +L++ A+E ++RA+ +K + E ++
Sbjct: 2288 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2347
Query: 428 ---------ELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQS-QEAEKEEKRREFEAGV 477
EL ++KE + R QE ++Q+ Q+A + Q Q + E++R+ E
Sbjct: 2348 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2407
Query: 478 AANKMCL 484
A ++ L
Sbjct: 2408 EAERLKL 2414
Score = 85.5 bits (210), Expect = 1e-16
Identities = 110/422 (26%), Positives = 192/422 (45%), Gaps = 53/422 (12%)
Query: 96 ERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQ 155
E +L E EE E E+ E EK+ ++ E K + E+E A++L Q
Sbjct: 1372 EEEERLAEQQRAEERERLAEV----EAALEKQRQLAEAHAQAKAQAERE-----AKELQQ 1422
Query: 156 QFRE---RCEELRVELLSIHQKKVCEERKAQIAFNEEL-----SRQKLVEEQMFSKLWEE 207
+ +E R EE V+ + QK+ +E Q+ + E +RQ E+ ++ EE
Sbjct: 1423 RMQEEVVRREEAAVD--AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1480
Query: 208 DRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIK 267
R+ + + EA E RQ+ E L A+ +AQ++ Q E R V+ + +Q K
Sbjct: 1481 IRVVRLQLEATE--RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ-DESQRK 1537
Query: 268 HENEQDMLKKQKAKQETRTILQKALQE------RIEHIQQEYRDEQDLNMKLVQRALQDL 321
+ E ++ + KA+ E Q+ALQ + E ++ R + + VQ AL+
Sbjct: 1538 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1597
Query: 322 QEEADKKKQ--------KREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLA 373
Q A+ + Q K + R + H +AQ REE E+ + E ++A++ A
Sbjct: 1598 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE---AERRAQQQAEAERAREEA 1654
Query: 374 EKDKE---LRLEKEARRQLVDEVMCTRKLQVQ-------EKLQREAKEQ---EERAMEQK 420
E++ E L+ + R +L E + +K Q E+ +REA+ + EE+A+ Q+
Sbjct: 1655 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1714
Query: 421 HINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAY-QQQSQEAEKEEKRREFEAGVAA 479
+ E E + E A+++ A++ +L+ + +QQ Q E+E R + EA A
Sbjct: 1715 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1774
Query: 480 NK 481
K
Sbjct: 1775 QK 1776
Score = 79.7 bits (195), Expect = 6e-15
Identities = 115/542 (21%), Positives = 227/542 (41%), Gaps = 98/542 (18%)
Query: 33 AEHHLERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFII 92
A+ ER+RR Q + + R+KAE + + + R A++ +
Sbjct: 1519 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE--------KQRALQALEELRL 1570
Query: 93 NIEERRNKLRELLALEENEYFTEMQLKKET--------IEEKKDRMREKTKLLKEKNEKE 144
EE +LR+ E E ++Q+ ET ++ K+ EKT L+ ++E
Sbjct: 1571 QAEEAERRLRQA----EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1626
Query: 145 -------RQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVE 197
R++ Q ER E L Q K E + ++ E ++ L +
Sbjct: 1627 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1686
Query: 198 EQMFSKLWEEDRLAKEKREA------------QEARRQKELMENT---RLGLNAQITSIK 242
+ + E +R A+ + +A QE +Q++L E T RL ++ ++
Sbjct: 1687 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1746
Query: 243 AQ----RQATQLLKEEEARL-------------VESNNAQIKHENEQDMLKKQKAKQETR 285
A+ Q QLL+EE ARL +E+ A+++ E E + K +A++E+R
Sbjct: 1747 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1806
Query: 286 TILQKALQE----------------RIEHIQQEYRDEQDLNMKLVQRALQDLQE------ 323
+ +K+ Q R+ + +E + ++ L + R + +
Sbjct: 1807 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1866
Query: 324 ----EADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKA---KKLAEKD 376
EA + K + E ++E++ ++ L + E+E Q + + + KA ++LA+
Sbjct: 1867 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1926
Query: 377 KELRLEKEARRQLVDEVMCTRKLQVQEKL-------QREAKEQEERAMEQKHINESLKEL 429
K E E ++ LV++ + R+ QV+E++ ++ A + E +E I + ++
Sbjct: 1927 KASDSELERQKGLVEDTLRQRR-QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 1985
Query: 430 --NCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKV 487
+ E+ E A RQR ++ + + + Q A +EE R+ +A + + KV
Sbjct: 1986 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2045
Query: 488 QE 489
+E
Sbjct: 2046 EE 2047
Score = 79.0 bits (193), Expect = 1e-14
Identities = 88/386 (22%), Positives = 183/386 (47%), Gaps = 21/386 (5%)
Query: 92 INIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKN-EKERQDFVA 150
I ++E+ + L L E+E F +L+++ + K D +L K + E ERQ +
Sbjct: 1881 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1940
Query: 151 EKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSR-QKLVEEQMFSKLWEEDR 209
E +Q R+ EE+ + L + +K + + ++ EL R + E+ + SK E
Sbjct: 1941 EDTLRQRRQVEEEI-LALKASFEKAAAGKAELEL----ELGRIRSNAEDTLRSKEQAELE 1995
Query: 210 LAKEKR-EAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKH 268
A++++ A+E RR++E E + L A+ + + ++ A + ++ +A++ E+ +++
Sbjct: 1996 AARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR--RLRE 2053
Query: 269 ENEQDMLKKQKAKQETRTILQKALQ-ERIEHIQQEYRDEQDLNMKLVQR--ALQDLQEEA 325
EQ+ ++ + QE QK LQ E H + EQ+L L Q L L+ EA
Sbjct: 2054 RAEQESARQLQLAQEAA---QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2110
Query: 326 DKKKQKREDMIREQKIYHKYLAQRR----EEEKAQEKEFDRILEEDKAKKLAEKDKELRL 381
+ ++ E+ + + AQ R E E+ ++ ++ +A+ AEK ++
Sbjct: 2111 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2170
Query: 382 EKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQ 441
++ ARR ++ +K ++++ K E+ ++ + + L L + +E ++
Sbjct: 2171 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2230
Query: 442 RLAQE-YRKQLQMQIAYQQQSQEAEK 466
L +E R + + A +Q+SQ E+
Sbjct: 2231 LLDEELQRLKAEATEAARQRSQVEEE 2256
Score = 72.8 bits (177), Expect = 7e-13
Identities = 65/280 (23%), Positives = 143/280 (51%), Gaps = 29/280 (10%)
Query: 194 KLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKE 253
K + E + ++ EE+RLA+++R A+E R E+ +++ QRQ + +
Sbjct: 1362 KFISETL-RRMEEEERLAEQQR-AEERERLAEVE-----------AALEKQRQLAEAHAQ 1408
Query: 254 EEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKL 313
+A+ E +++ +++++++++A + + ++++QE ++ ++Q E ++ K
Sbjct: 1409 AKAQ-AEREAKELQQRMQEEVVRREEAAVDAQQ-QKRSIQEELQQLRQS--SEAEIQAKA 1464
Query: 314 VQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLA 373
Q E A++ + + E+ IR ++ + ++R + + + EE +A+K
Sbjct: 1465 RQA------EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1518
Query: 374 EKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEE 433
+++ RL RRQ+ DE RK Q + +L K + E A E++ ++L+EL +
Sbjct: 1519 AQEEAERL----RRQVQDESQ--RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1572
Query: 434 KENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREF 473
+E R ++ E +Q+Q+ + Q+S EAE + KR F
Sbjct: 1573 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1612
Score = 71.6 bits (174), Expect = 2e-12
Identities = 112/526 (21%), Positives = 218/526 (41%), Gaps = 92/526 (17%)
Query: 41 RRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNK 100
+RS + ++ E +LKA + N IL R KD Q F+ E+ +
Sbjct: 2249 QRSQVEEELFSVRVQMEELSKLKARIEAENRALIL------RDKDNTQRFLQEEAEKMKQ 2302
Query: 101 LRE--------------LLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQ 146
+ E L L E + + L ++ ++EK ++E T+L E ++Q
Sbjct: 2303 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2362
Query: 147 DFVAEKLDQQFRERCEELRVELLSI---HQKKVCEERKAQIAFNEELSRQKL-VEEQMFS 202
+A++ ++ +E E++ +L Q+ + ER+ Q+ + E R KL V E +
Sbjct: 2363 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2422
Query: 203 KLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQIT---SIKAQRQAT----------- 248
+ E+ + +++A+E E + T L ++T +++ QRQ +
Sbjct: 2423 QARAEEDAQRFRKQAEEIG---EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2479
Query: 249 -QLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQ------- 300
+L +E+E E+ Q+K E E +++++ QET+ + Q L E+ +Q
Sbjct: 2480 AELEREKEKLQQEAKLLQLKSE-EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2538
Query: 301 ----------------QEYRDEQDLNMKLVQRALQDL---QEEADKKKQKREDMIR-EQK 340
Q+ R+EQ + +++ Q L EEA +++ + E+ +R +Q+
Sbjct: 2539 EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE 2598
Query: 341 IYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKL- 399
+ QRR++E+ +E R+ E+ +L E+ L + +V T+ L
Sbjct: 2599 ELQQLEQQRRQQEELLAEENQRLREQ---LQLLEEQHRAAL-AHSEEVTASQVAATKTLP 2654
Query: 400 QVQEKLQREAKEQEER----AMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQI 455
++ L A E E + +K + L+E E QRLAQ
Sbjct: 2655 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL---QRLAQ---------- 2701
Query: 456 AYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEVLSTHQVLPQNI 501
+ + A +E+ R + + + L E LS + L + +
Sbjct: 2702 GHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQL 2747
Score = 48.1 bits (113), Expect = 2e-05
Identities = 80/337 (23%), Positives = 143/337 (42%), Gaps = 63/337 (18%)
Query: 149 VAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEED 208
V E+L Q+ ER ++ VE ++ E +A +A Q V ++ +L +
Sbjct: 1186 VGERLQQRHGER--DVEVERWRERVAQLLERWQAVLA-------QTDVRQRELEQLGRQL 1236
Query: 209 RLAKEKREA-----QEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNN 263
R +E + Q+ARR++E ++ L A +++ Q + Q L EE
Sbjct: 1237 RYYRESADPLGAWLQDARRRQEQIQAMPL---ADSQAVREQLRQEQALLEE--------- 1284
Query: 264 AQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQE 323
I+ E+ ++ AKQ I LQ Q E K+ + +QE
Sbjct: 1285 --IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1342
Query: 324 EADKKKQKREDMIREQKIYHKYLAQ--RREEEKAQEKEFDRILEEDKAKKLAEKDKELRL 381
D + E + Y K++++ RR EE+ +R+ E+ +A++ E+ E+
Sbjct: 1343 YVDLRTHYSE-LTTLTSQYIKFISETLRRMEEE------ERLAEQQRAEE-RERLAEVEA 1394
Query: 382 EKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQ 441
E +RQL + Q + + +REAKE ++R E+ RR+
Sbjct: 1395 ALEKQRQLAEA-----HAQAKAQAEREAKELQQRMQEE-----------------VVRRE 1432
Query: 442 RL---AQEYRKQLQMQIAYQQQSQEAEKEEKRREFEA 475
AQ+ ++ +Q ++ +QS EAE + K R+ EA
Sbjct: 1433 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1469
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 90.9 bits (224), Expect = 3e-18
Identities = 72/299 (24%), Positives = 150/299 (50%), Gaps = 46/299 (15%)
Query: 212 KEKREAQEARRQK------ELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQ 265
+ K EA++ RRQK +E +L ++ + R+ + +KEE+ + +E AQ
Sbjct: 546 RRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQ 605
Query: 266 IKHENE---QDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLN-MKLVQRALQDL 321
I + E ++ L ++KAK+ KA +++E ++ + E++ ++ +Q+ ++
Sbjct: 606 IDEKTEKAKEERLAEEKAKK-------KAAAKKMEEVEARRKQEEEARRLRWLQQEEEER 658
Query: 322 QEEADKKKQKREDMIREQKIYH-KYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELR 380
+ + +K+K E+ R +K K LA++RE+E+ +++ ++ E + ++ +++E +
Sbjct: 659 RHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQ 718
Query: 381 LEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARR 440
L ++ RR+ + + R+LQ +EK R KEQ +R +E+K E +
Sbjct: 719 LAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKE--------------EQ 764
Query: 441 QRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEVLSTHQVLPQ 499
QRLA+ +QLQ E+E+K +E A + +D +++Q+ PQ
Sbjct: 765 QRLAE---RQLQ-----------EEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQ 809
Score = 84.7 bits (208), Expect = 2e-16
Identities = 82/320 (25%), Positives = 159/320 (49%), Gaps = 74/320 (23%)
Query: 94 IEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKL 153
+E+ R +L L EE E QL+++ +EE K R E+ KL +E+ ++
Sbjct: 535 VEKERQRLENLRRKEEAE-----QLRRQKVEEDKRRRLEEVKLKREERLRKVL------- 582
Query: 154 DQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKE 213
Q RER E+++ EE+K QI EQ F+++ E+ AKE
Sbjct: 583 --QARERVEQMK------------EEKKKQI-------------EQKFAQIDEKTEKAKE 615
Query: 214 KREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQD 273
+R A+E ++K + ++ ++A+R+ +EEEAR + + + Q+
Sbjct: 616 ERLAEEKAKKKAAAK--------KMEEVEARRK-----QEEEARRLRWLQQEEEERRHQE 662
Query: 274 MLKKQKAKQETRTILQKALQER--IEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQK 331
+L+K+K +++ R L+KA + + E +QE R+ Q+ +E+ +++++
Sbjct: 663 LLQKKKEEEQER--LRKAAEAKRLAEQREQERRE-------------QERREQERREQER 707
Query: 332 REDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVD 391
RE REQ+ +RRE+E+ Q + + E +KA +L ++ + LE++ +++
Sbjct: 708 REQERREQERQLAEQERRREQERLQAER--ELQEREKALRLQKEQLQRELEEKKKKE--- 762
Query: 392 EVMCTRKLQVQEKLQREAKE 411
E + Q+QE+ +++AKE
Sbjct: 763 EQQRLAERQLQEEQEKKAKE 782
Score = 66.2 bits (160), Expect = 7e-11
Identities = 70/283 (24%), Positives = 139/283 (49%), Gaps = 60/283 (21%)
Query: 226 LMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETR 285
+ NT L ++ + + ++ +RQ + L+ +E E Q E+++ L++ K K+E R
Sbjct: 520 IKRNTPLRMDPKCSFVEKERQRLENLRRKEE--AEQLRRQKVEEDKRRRLEEVKLKREER 577
Query: 286 TILQKALQ--ERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYH 343
L+K LQ ER+E +++E + K +++ + E+ +K K++R + E+K
Sbjct: 578 --LRKVLQARERVEQMKEEKK-------KQIEQKFAQIDEKTEKAKEER---LAEEKAKK 625
Query: 344 KYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQE 403
K A++ EE +A+ K+ E++A++L + L+ E+E RR QE
Sbjct: 626 KAAAKKMEEVEARRKQ------EEEARRL----RWLQQEEEERRH-------------QE 662
Query: 404 KLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQE 463
LQ++ +E++ER + A +RLA++ ++ + Q +Q+ +E
Sbjct: 663 LLQKKKEEEQERLRKA------------------AEAKRLAEQREQERREQERREQERRE 704
Query: 464 AEK-EEKRREFEAGVAANKMCLDKVQEVLSTHQVLPQNIHPMR 505
E+ E++RRE E +A + + QE L + L + +R
Sbjct: 705 QERREQERREQERQLAEQER--RREQERLQAERELQEREKALR 745
Score = 48.9 bits (115), Expect = 1e-05
Identities = 49/195 (25%), Positives = 89/195 (45%), Gaps = 18/195 (9%)
Query: 38 ERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEER 97
E+ ++ QK I + ++ +RL E + V AR K EE
Sbjct: 594 EKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQ---------EEE 644
Query: 98 RNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQF 157
+LR L EE E+ KK+ E+++ R + K L E+ E+ER++ + +++
Sbjct: 645 ARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERRE 704
Query: 158 RERCEELRVE----LLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKE 213
+ER E+ R E L +++ E +A+ E +L +EQ+ +L E K+
Sbjct: 705 QERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEE-----KK 759
Query: 214 KREAQEARRQKELME 228
K+E Q+ +++L E
Sbjct: 760 KKEEQQRLAERQLQE 774
>gi|217272804 hyaluronan-mediated motility receptor isoform d [Homo
sapiens]
Length = 638
Score = 88.6 bits (218), Expect = 1e-17
Identities = 119/517 (23%), Positives = 249/517 (48%), Gaps = 67/517 (12%)
Query: 23 VRSKPPKGQGAEHHLERIRRSHQKHNAILASIK----SSERDRLKAEWDQHNDCKILDSL 78
+R K +G E L+ +RS ++ +A ++ S E++++ + + + ++ +
Sbjct: 95 MRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEI 154
Query: 79 VRARIKDAVQGFIINIEERRNKLREL--------LALEEN-----EYFTEMQLKKETIEE 125
A D V+ + ++I + L+E +LEEN + ++ +K + +E+
Sbjct: 155 SCA--SDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEK 212
Query: 126 KKD----RMREKTKLLKEKNEKERQDFVAEKLDQQFRERCE--ELRVELLSIHQKKVCEE 179
+K+ R RE + L + + +Q F+ L+QQ RE+ + EL+++ L +K++
Sbjct: 213 EKEDHVNRNREHNENLNAEMQNLKQKFI---LEQQEREKLQQKELQIDSLLQQEKELSSS 269
Query: 180 RKAQI-AFNEELSRQK-LVEEQMFSKLWEEDRLAKEKREAQEARRQKE-----------L 226
++ +F EE+ ++K L EE++ L E D+L +++ +A+ +Q E L
Sbjct: 270 LHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKL 329
Query: 227 MENTRLGLNAQIT-SIKAQRQATQLLKEEEARLVESNN---AQIKHENEQDMLKKQKAKQ 282
+E G A++ S A QAT LL+E+ +V+S AQ + + + K
Sbjct: 330 LEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKL 389
Query: 283 ETRTILQKALQ--ERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQK 340
E ++ +KA + + E +Q + + N + V R L DLQ K +E I+E
Sbjct: 390 ENSSLQEKAAKAGKNAEDVQHQILATESSNQEYV-RMLLDLQT----KSALKETEIKEIT 444
Query: 341 I-YHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARR-QLVDEVMCTRK 398
+ + + + + + K QE++F + LE+++ +K +++ L +E + +L+ E + +
Sbjct: 445 VSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKT 504
Query: 399 LQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFAR---RQRLAQEYRKQLQMQI 455
Q LQ +A E E++A+ +H + ++LN + ++++A+ Q L Q+ + ++++
Sbjct: 505 KPFQ--LQLDAFEVEKQALLNEH-GAAQEQLN-KIRDSYAKLLGHQNLKQKIKHVVKLKD 560
Query: 456 AYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEVLS 492
Q E K +A K K+QE L+
Sbjct: 561 ENSQLKSEVSK------LRCQLAKKKQSETKLQEELN 591
Score = 63.5 bits (153), Expect = 4e-10
Identities = 87/394 (22%), Positives = 172/394 (43%), Gaps = 31/394 (7%)
Query: 100 KLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDF---VAEKLDQQ 156
+ ELL + +E + L+ ++E K R + +TK+ ++E + V ++ ++
Sbjct: 59 RTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEE 118
Query: 157 FRERCEELRVELLSIHQKKVCEERKAQ--IAFNEELSRQKLVEEQMFSKLWEEDRLAKEK 214
+ + +L +L+SI ++K+ E+ + + + + EE+S E+ + + + KEK
Sbjct: 119 SQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEK 178
Query: 215 REAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDM 274
+ E K+ +E + L+ Q+ + + Q + KE+ +N + E +
Sbjct: 179 ND--EILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLK 236
Query: 275 LKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKRE- 333
K +QE + QK LQ I + E++L+ L Q+ L QEE K+K E
Sbjct: 237 QKFILEQQEREKLQQKELQ-----IDSLLQQEKELSSSLHQK-LCSFQEEMVKEKNLFEE 290
Query: 334 ---------DMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKE 384
D +++++ + L ++ EEE E ++LEE K AE +K +
Sbjct: 291 ELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQ 350
Query: 385 ARRQLVDE----VMCTRKLQVQEKLQR--EAKEQEERAMEQKHINESLKELNCEEKENFA 438
A L ++ V + Q + + A E E+ +E + E K +
Sbjct: 351 ATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQE--KAAKAGKNAEDV 408
Query: 439 RRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRRE 472
+ Q LA E Q +++ Q++ A KE + +E
Sbjct: 409 QHQILATESSNQEYVRMLLDLQTKSALKETEIKE 442
Score = 56.6 bits (135), Expect = 5e-08
Identities = 74/335 (22%), Positives = 144/335 (42%), Gaps = 33/335 (9%)
Query: 160 RCEELRVELLSIHQK-KVCEERKAQIAFNEELSRQKLVE-----EQMFSKLWEEDRLAKE 213
R ++L EL + + K ++ N ++L+E E + SK E
Sbjct: 18 RIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNL 77
Query: 214 KREAQEARRQKELMENTRLGLNAQITSIKAQRQATQL-LKEEEARLVESNNAQIKHENEQ 272
+ + E + + E G+ A+ ++ + Q TQ L+E + ++ + + E E
Sbjct: 78 RILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKE- 136
Query: 273 DMLKKQKAKQETRTILQKALQERIEHIQ--QEYRDEQDLNMKLVQRALQDLQEEADKKKQ 330
K K ET +L E IE I + ++ L++ ++ L++ +E KQ
Sbjct: 137 ----KIDEKSETEKLL-----EYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQ 187
Query: 331 KREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLV 390
E+ I I K + + + EKE +ED + E ++ L E + +Q
Sbjct: 188 SLEENI---VILSKQVEDLNVKCQLLEKE-----KEDHVNRNREHNENLNAEMQNLKQKF 239
Query: 391 DEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQ 450
+ Q +EKLQ++ + + ++K ++ SL + C +E + + L +E KQ
Sbjct: 240 -----ILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQ 294
Query: 451 LQMQI-AYQQQSQEAEKEEKRREFEAGVAANKMCL 484
++ QQ+ ++AE+ K+ E EA A ++ L
Sbjct: 295 TLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKL 329
>gi|217272802 hyaluronan-mediated motility receptor isoform a [Homo
sapiens]
Length = 725
Score = 88.6 bits (218), Expect = 1e-17
Identities = 119/517 (23%), Positives = 249/517 (48%), Gaps = 67/517 (12%)
Query: 23 VRSKPPKGQGAEHHLERIRRSHQKHNAILASIK----SSERDRLKAEWDQHNDCKILDSL 78
+R K +G E L+ +RS ++ +A ++ S E++++ + + + ++ +
Sbjct: 182 MRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEI 241
Query: 79 VRARIKDAVQGFIINIEERRNKLREL--------LALEEN-----EYFTEMQLKKETIEE 125
A D V+ + ++I + L+E +LEEN + ++ +K + +E+
Sbjct: 242 SCA--SDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEK 299
Query: 126 KKD----RMREKTKLLKEKNEKERQDFVAEKLDQQFRERCE--ELRVELLSIHQKKVCEE 179
+K+ R RE + L + + +Q F+ L+QQ RE+ + EL+++ L +K++
Sbjct: 300 EKEDHVNRNREHNENLNAEMQNLKQKFI---LEQQEREKLQQKELQIDSLLQQEKELSSS 356
Query: 180 RKAQI-AFNEELSRQK-LVEEQMFSKLWEEDRLAKEKREAQEARRQKE-----------L 226
++ +F EE+ ++K L EE++ L E D+L +++ +A+ +Q E L
Sbjct: 357 LHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKL 416
Query: 227 MENTRLGLNAQIT-SIKAQRQATQLLKEEEARLVESNN---AQIKHENEQDMLKKQKAKQ 282
+E G A++ S A QAT LL+E+ +V+S AQ + + + K
Sbjct: 417 LEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKL 476
Query: 283 ETRTILQKALQ--ERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQK 340
E ++ +KA + + E +Q + + N + V R L DLQ K +E I+E
Sbjct: 477 ENSSLQEKAAKAGKNAEDVQHQILATESSNQEYV-RMLLDLQT----KSALKETEIKEIT 531
Query: 341 I-YHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARR-QLVDEVMCTRK 398
+ + + + + + K QE++F + LE+++ +K +++ L +E + +L+ E + +
Sbjct: 532 VSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKT 591
Query: 399 LQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFAR---RQRLAQEYRKQLQMQI 455
Q LQ +A E E++A+ +H + ++LN + ++++A+ Q L Q+ + ++++
Sbjct: 592 KPFQ--LQLDAFEVEKQALLNEH-GAAQEQLN-KIRDSYAKLLGHQNLKQKIKHVVKLKD 647
Query: 456 AYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEVLS 492
Q E K +A K K+QE L+
Sbjct: 648 ENSQLKSEVSK------LRCQLAKKKQSETKLQEELN 678
Score = 65.1 bits (157), Expect = 1e-10
Identities = 86/408 (21%), Positives = 174/408 (42%), Gaps = 47/408 (11%)
Query: 101 LRELLALEENEYFTEMQLKKETIEEKKDRM----REKTKLLKEKNEKERQDFVAEKLDQQ 156
L+ ++ ++++ F + + K+ + KD K K + K E ++ D + L+++
Sbjct: 32 LKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKE 91
Query: 157 FR----------ERCEELRVELLSIHQK-KVCEERKAQIAFNEELSRQKLVE-----EQM 200
R R ++L EL + + K ++ N ++L+E E +
Sbjct: 92 IRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELL 151
Query: 201 FSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQL-LKEEEARLV 259
SK E + + E + + E G+ A+ ++ + Q TQ L+E + ++
Sbjct: 152 KSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIA 211
Query: 260 ESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQ--QEYRDEQDLNMKLVQRA 317
+ + E E K K ET +L E IE I + ++ L++ ++
Sbjct: 212 QLEGKLVSIEKE-----KIDEKSETEKLL-----EYIEEISCASDQVEKYKLDIAQLEEN 261
Query: 318 LQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDK 377
L++ +E KQ E+ I I K + + + EKE +ED + E ++
Sbjct: 262 LKEKNDEILSLKQSLEENI---VILSKQVEDLNVKCQLLEKE-----KEDHVNRNREHNE 313
Query: 378 ELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENF 437
L E + +Q + Q +EKLQ++ + + ++K ++ SL + C +E
Sbjct: 314 NLNAEMQNLKQKF-----ILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEM 368
Query: 438 ARRQRLAQEYRKQLQMQI-AYQQQSQEAEKEEKRREFEAGVAANKMCL 484
+ + L +E KQ ++ QQ+ ++AE+ K+ E EA A ++ L
Sbjct: 369 VKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKL 416
Score = 63.9 bits (154), Expect = 3e-10
Identities = 110/474 (23%), Positives = 202/474 (42%), Gaps = 68/474 (14%)
Query: 54 IKSSERDRLKAEWDQHNDCKILDSLVRA----------RIKDAVQGFIINIEERRNK-LR 102
+KSSE + + D+ D KIL+ +R RI+D ++ + +E R N LR
Sbjct: 69 VKSSESKKESQKNDK--DLKILEKEIRVLLQERGAQDRRIQD-LETELEKMEARLNAALR 125
Query: 103 ELLALEENEYFTEMQLKK--ETIEEKKDRMREK----------TKLLKEKNEKE------ 144
E +L N E QL + T E K + E +L+K +N++E
Sbjct: 126 EKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGM 185
Query: 145 --RQDFVAEKLD------QQFRERCEELRVELLSIHQKKVCEERKAQ--IAFNEELSRQK 194
+Q+ + KL ++ + + +L +L+SI ++K+ E+ + + + + EE+S
Sbjct: 186 MAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCAS 245
Query: 195 LVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEE 254
E+ + + + KEK + E K+ +E + L+ Q+ + + Q + KE+
Sbjct: 246 DQVEKYKLDIAQLEENLKEKND--EILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKED 303
Query: 255 EARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLV 314
+N + E + K +QE + QK LQ I + E++L+ L
Sbjct: 304 HVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQ-----IDSLLQQEKELSSSLH 358
Query: 315 QRALQDLQEEADKKKQKRE----------DMIREQKIYHKYLAQRREEEKAQEKEFDRIL 364
Q+ L QEE K+K E D +++++ + L ++ EEE E ++L
Sbjct: 359 QK-LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLL 417
Query: 365 EEDKAKKLAEKDKELRLEKEARRQLVDE----VMCTRKLQVQEKLQR--EAKEQEERAME 418
EE K AE +K +A L ++ V + Q + + A E E+ +E
Sbjct: 418 EEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLE 477
Query: 419 QKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRRE 472
+ E K + + Q LA E Q +++ Q++ A KE + +E
Sbjct: 478 NSSLQE--KAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKE 529
>gi|217416398 hyaluronan-mediated motility receptor isoform c [Homo
sapiens]
Length = 709
Score = 88.6 bits (218), Expect = 1e-17
Identities = 119/517 (23%), Positives = 249/517 (48%), Gaps = 67/517 (12%)
Query: 23 VRSKPPKGQGAEHHLERIRRSHQKHNAILASIK----SSERDRLKAEWDQHNDCKILDSL 78
+R K +G E L+ +RS ++ +A ++ S E++++ + + + ++ +
Sbjct: 166 MRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEI 225
Query: 79 VRARIKDAVQGFIINIEERRNKLREL--------LALEEN-----EYFTEMQLKKETIEE 125
A D V+ + ++I + L+E +LEEN + ++ +K + +E+
Sbjct: 226 SCA--SDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEK 283
Query: 126 KKD----RMREKTKLLKEKNEKERQDFVAEKLDQQFRERCE--ELRVELLSIHQKKVCEE 179
+K+ R RE + L + + +Q F+ L+QQ RE+ + EL+++ L +K++
Sbjct: 284 EKEDHVNRNREHNENLNAEMQNLKQKFI---LEQQEREKLQQKELQIDSLLQQEKELSSS 340
Query: 180 RKAQI-AFNEELSRQK-LVEEQMFSKLWEEDRLAKEKREAQEARRQKE-----------L 226
++ +F EE+ ++K L EE++ L E D+L +++ +A+ +Q E L
Sbjct: 341 LHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKL 400
Query: 227 MENTRLGLNAQIT-SIKAQRQATQLLKEEEARLVESNN---AQIKHENEQDMLKKQKAKQ 282
+E G A++ S A QAT LL+E+ +V+S AQ + + + K
Sbjct: 401 LEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKL 460
Query: 283 ETRTILQKALQ--ERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQK 340
E ++ +KA + + E +Q + + N + V R L DLQ K +E I+E
Sbjct: 461 ENSSLQEKAAKAGKNAEDVQHQILATESSNQEYV-RMLLDLQT----KSALKETEIKEIT 515
Query: 341 I-YHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARR-QLVDEVMCTRK 398
+ + + + + + K QE++F + LE+++ +K +++ L +E + +L+ E + +
Sbjct: 516 VSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKT 575
Query: 399 LQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFAR---RQRLAQEYRKQLQMQI 455
Q LQ +A E E++A+ +H + ++LN + ++++A+ Q L Q+ + ++++
Sbjct: 576 KPFQ--LQLDAFEVEKQALLNEH-GAAQEQLN-KIRDSYAKLLGHQNLKQKIKHVVKLKD 631
Query: 456 AYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEVLS 492
Q E K +A K K+QE L+
Sbjct: 632 ENSQLKSEVSK------LRCQLAKKKQSETKLQEELN 662
Score = 63.5 bits (153), Expect = 4e-10
Identities = 82/392 (20%), Positives = 168/392 (42%), Gaps = 31/392 (7%)
Query: 101 LRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRER 160
L+ ++ ++++ F + + K+ + KD + + +E + + + E+ Q R +
Sbjct: 32 LKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQ 91
Query: 161 CEELRVELLSIHQKKVCEERKAQIAFNEELSRQKL----VEEQMFSKLWEEDRLAKEKRE 216
E +E + E+ + A N L +Q + E + SK E +
Sbjct: 92 DLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRIL 151
Query: 217 AQEARRQKELMENTRLGLNAQITSIKAQRQATQL-LKEEEARLVESNNAQIKHENEQDML 275
+ E + + E G+ A+ ++ + Q TQ L+E + ++ + + E E
Sbjct: 152 SLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKE---- 207
Query: 276 KKQKAKQETRTILQKALQERIEHIQ--QEYRDEQDLNMKLVQRALQDLQEEADKKKQKRE 333
K K ET +L E IE I + ++ L++ ++ L++ +E KQ E
Sbjct: 208 -KIDEKSETEKLL-----EYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLE 261
Query: 334 DMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEV 393
+ I I K + + + EKE +ED + E ++ L E + +Q
Sbjct: 262 ENI---VILSKQVEDLNVKCQLLEKE-----KEDHVNRNREHNENLNAEMQNLKQKF--- 310
Query: 394 MCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQM 453
+ Q +EKLQ++ + + ++K ++ SL + C +E + + L +E KQ
Sbjct: 311 --ILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLD 368
Query: 454 QI-AYQQQSQEAEKEEKRREFEAGVAANKMCL 484
++ QQ+ ++AE+ K+ E EA A ++ L
Sbjct: 369 ELDKLQQKEEQAERLVKQLEEEAKSRAEELKL 400
Score = 63.5 bits (153), Expect = 4e-10
Identities = 87/394 (22%), Positives = 172/394 (43%), Gaps = 31/394 (7%)
Query: 100 KLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDF---VAEKLDQQ 156
+ ELL + +E + L+ ++E K R + +TK+ ++E + V ++ ++
Sbjct: 130 RTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEE 189
Query: 157 FRERCEELRVELLSIHQKKVCEERKAQ--IAFNEELSRQKLVEEQMFSKLWEEDRLAKEK 214
+ + +L +L+SI ++K+ E+ + + + + EE+S E+ + + + KEK
Sbjct: 190 SQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEK 249
Query: 215 REAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDM 274
+ E K+ +E + L+ Q+ + + Q + KE+ +N + E +
Sbjct: 250 ND--EILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLK 307
Query: 275 LKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKRE- 333
K +QE + QK LQ I + E++L+ L Q+ L QEE K+K E
Sbjct: 308 QKFILEQQEREKLQQKELQ-----IDSLLQQEKELSSSLHQK-LCSFQEEMVKEKNLFEE 361
Query: 334 ---------DMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKE 384
D +++++ + L ++ EEE E ++LEE K AE +K +
Sbjct: 362 ELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQ 421
Query: 385 ARRQLVDE----VMCTRKLQVQEKLQR--EAKEQEERAMEQKHINESLKELNCEEKENFA 438
A L ++ V + Q + + A E E+ +E + E K +
Sbjct: 422 ATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQE--KAAKAGKNAEDV 479
Query: 439 RRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRRE 472
+ Q LA E Q +++ Q++ A KE + +E
Sbjct: 480 QHQILATESSNQEYVRMLLDLQTKSALKETEIKE 513
>gi|217416394 hyaluronan-mediated motility receptor isoform b [Homo
sapiens]
Length = 724
Score = 88.6 bits (218), Expect = 1e-17
Identities = 119/517 (23%), Positives = 249/517 (48%), Gaps = 67/517 (12%)
Query: 23 VRSKPPKGQGAEHHLERIRRSHQKHNAILASIK----SSERDRLKAEWDQHNDCKILDSL 78
+R K +G E L+ +RS ++ +A ++ S E++++ + + + ++ +
Sbjct: 181 MRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEI 240
Query: 79 VRARIKDAVQGFIINIEERRNKLREL--------LALEEN-----EYFTEMQLKKETIEE 125
A D V+ + ++I + L+E +LEEN + ++ +K + +E+
Sbjct: 241 SCA--SDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEK 298
Query: 126 KKD----RMREKTKLLKEKNEKERQDFVAEKLDQQFRERCE--ELRVELLSIHQKKVCEE 179
+K+ R RE + L + + +Q F+ L+QQ RE+ + EL+++ L +K++
Sbjct: 299 EKEDHVNRNREHNENLNAEMQNLKQKFI---LEQQEREKLQQKELQIDSLLQQEKELSSS 355
Query: 180 RKAQI-AFNEELSRQK-LVEEQMFSKLWEEDRLAKEKREAQEARRQKE-----------L 226
++ +F EE+ ++K L EE++ L E D+L +++ +A+ +Q E L
Sbjct: 356 LHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKL 415
Query: 227 MENTRLGLNAQIT-SIKAQRQATQLLKEEEARLVESNN---AQIKHENEQDMLKKQKAKQ 282
+E G A++ S A QAT LL+E+ +V+S AQ + + + K
Sbjct: 416 LEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKL 475
Query: 283 ETRTILQKALQ--ERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQK 340
E ++ +KA + + E +Q + + N + V R L DLQ K +E I+E
Sbjct: 476 ENSSLQEKAAKAGKNAEDVQHQILATESSNQEYV-RMLLDLQT----KSALKETEIKEIT 530
Query: 341 I-YHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARR-QLVDEVMCTRK 398
+ + + + + + K QE++F + LE+++ +K +++ L +E + +L+ E + +
Sbjct: 531 VSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKT 590
Query: 399 LQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFAR---RQRLAQEYRKQLQMQI 455
Q LQ +A E E++A+ +H + ++LN + ++++A+ Q L Q+ + ++++
Sbjct: 591 KPFQ--LQLDAFEVEKQALLNEH-GAAQEQLN-KIRDSYAKLLGHQNLKQKIKHVVKLKD 646
Query: 456 AYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQEVLS 492
Q E K +A K K+QE L+
Sbjct: 647 ENSQLKSEVSK------LRCQLAKKKQSETKLQEELN 677
Score = 63.9 bits (154), Expect = 3e-10
Identities = 109/482 (22%), Positives = 200/482 (41%), Gaps = 66/482 (13%)
Query: 46 KHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRA----------RIKDAVQGFIINIE 95
K + AS + + K D KIL+ +R RI+D ++ + +E
Sbjct: 58 KDTTLPASARKVKSSESKESQKNDKDLKILEKEIRVLLQERGAQDRRIQD-LETELEKME 116
Query: 96 ERRNK-LRELLALEENEYFTEMQLKK--ETIEEKKDRMREK----------TKLLKEKNE 142
R N LRE +L N E QL + T E K + E +L+K +N+
Sbjct: 117 ARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNK 176
Query: 143 KE--------RQDFVAEKLD------QQFRERCEELRVELLSIHQKKVCEERKAQ--IAF 186
+E +Q+ + KL ++ + + +L +L+SI ++K+ E+ + + + +
Sbjct: 177 RETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEY 236
Query: 187 NEELSRQKLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQ 246
EE+S E+ + + + KEK + E K+ +E + L+ Q+ + + Q
Sbjct: 237 IEEISCASDQVEKYKLDIAQLEENLKEKND--EILSLKQSLEENIVILSKQVEDLNVKCQ 294
Query: 247 ATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDE 306
+ KE+ +N + E + K +QE + QK LQ I + E
Sbjct: 295 LLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQ-----IDSLLQQE 349
Query: 307 QDLNMKLVQRALQDLQEEADKKKQKRE----------DMIREQKIYHKYLAQRREEEKAQ 356
++L+ L Q+ L QEE K+K E D +++++ + L ++ EEE
Sbjct: 350 KELSSSLHQK-LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKS 408
Query: 357 EKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDE----VMCTRKLQVQEKLQR--EAK 410
E ++LEE K AE +K +A L ++ V + Q + + A
Sbjct: 409 RAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTAS 468
Query: 411 EQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKR 470
E E+ +E + E K + + Q LA E Q +++ Q++ A KE +
Sbjct: 469 EIEDLKLENSSLQE--KAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEI 526
Query: 471 RE 472
+E
Sbjct: 527 KE 528
Score = 61.6 bits (148), Expect = 2e-09
Identities = 86/398 (21%), Positives = 173/398 (43%), Gaps = 36/398 (9%)
Query: 96 ERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKT-KLLKEKNEKERQDFVAEKLD 154
+++ + ++ L ++++ K ++ E K+ + +K K+L EKE + + E+
Sbjct: 45 KQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDLKIL----EKEIRVLLQERGA 100
Query: 155 QQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKL----VEEQMFSKLWEEDRL 210
Q R + E +E + E+ + A N L +Q + E + SK E
Sbjct: 101 QDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQ 160
Query: 211 AKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQL-LKEEEARLVESNNAQIKHE 269
+ + E + + E G+ A+ ++ + Q TQ L+E + ++ + + E
Sbjct: 161 KNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIE 220
Query: 270 NEQDMLKKQKAKQETRTILQKALQERIEHIQ--QEYRDEQDLNMKLVQRALQDLQEEADK 327
E K K ET +L E IE I + ++ L++ ++ L++ +E
Sbjct: 221 KE-----KIDEKSETEKLL-----EYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILS 270
Query: 328 KKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARR 387
KQ E+ I I K + + + EKE +ED + E ++ L E + +
Sbjct: 271 LKQSLEENI---VILSKQVEDLNVKCQLLEKE-----KEDHVNRNREHNENLNAEMQNLK 322
Query: 388 QLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEY 447
Q + Q +EKLQ++ + + ++K ++ SL + C +E + + L +E
Sbjct: 323 QKF-----ILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEE 377
Query: 448 RKQLQMQI-AYQQQSQEAEKEEKRREFEAGVAANKMCL 484
KQ ++ QQ+ ++AE+ K+ E EA A ++ L
Sbjct: 378 LKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKL 415
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 87.8 bits (216), Expect = 2e-17
Identities = 136/522 (26%), Positives = 236/522 (45%), Gaps = 88/522 (16%)
Query: 37 LERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEE 96
L++IR + + + ++S R KAE + + + L++L + ++D + E
Sbjct: 1103 LKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEAL-KTELEDTLDSTAAQQEL 1161
Query: 97 RRNKLREL----LALEENEYFTEMQLKK------ETIEEKKDRMREKTKLLKEKNEKERQ 146
R + +E+ LEE E Q+++ + +EE +++ E+TK +K EK +Q
Sbjct: 1162 RSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQL-EQTKRVKANLEKAKQ 1220
Query: 147 DFVAEKLDQQFRERCEELRVELL----SIHQKKVCEER--KAQIAFNE-ELSRQKLVE-- 197
L+ + E E++V L S H++K E + + Q+ FNE E R +L +
Sbjct: 1221 T-----LENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKV 1275
Query: 198 -------EQMFSKLWEED----RLAKE--KREAQEARRQKELMENTR--LGLNAQITSIK 242
+ + L + D +L K+ E+Q Q+ L E R L L+ ++ ++
Sbjct: 1276 TKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVE 1335
Query: 243 AQRQA--TQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQ---ETRTILQKALQERIE 297
++ + QL +EEEA+ H DM KK + ET +++ LQ+ +E
Sbjct: 1336 DEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLE 1395
Query: 298 HIQQEYRDEQDLNMKL------VQRALQDLQEEAD---------KKKQKREDMI--REQK 340
+ Q + ++ KL +Q+ L DL + D +KKQK+ D + E+
Sbjct: 1396 GLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKT 1455
Query: 341 IYHKYLAQR-REEEKAQEKE-----FDRILEEDKAKK--LAEKDKELRLEKEARRQLVDE 392
I KY +R R E +A+EKE R LEE +K L +K+ R E E D+
Sbjct: 1456 ISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDD 1515
Query: 393 V--------MCTRKL--QVQE-KLQREAKEQEERAMEQK--HINESLKELNCEEKENFAR 439
V R L QV+E K Q E E E +A E + +L+ + + + +
Sbjct: 1516 VGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQG 1575
Query: 440 RQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANK 481
R ++E +KQL Q+ + EAE E++R++ VAA K
Sbjct: 1576 RDEQSEEKKKQLVRQV----REMEAELEDERKQRSMAVAARK 1613
Score = 79.7 bits (195), Expect = 6e-15
Identities = 127/536 (23%), Positives = 235/536 (43%), Gaps = 107/536 (19%)
Query: 29 KGQG-AEHHLERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIK-DA 86
+G+G +EH +++ Q+ +K +E +R++ E + D + + +++ D
Sbjct: 1238 QGKGDSEHKRKKVEAQLQE-----LQVKFNEGERVRTE--------LADKVTKLQVELDN 1284
Query: 87 VQGFIINIEERRNKL-RELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKER 145
V G + + + +KL ++ ALE T+ L+ EE + ++ TKL + ++EK
Sbjct: 1285 VTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQ----EENRQKLSLSTKLKQVEDEKNS 1340
Query: 146 QDFVAEKLDQQFRERCEELRVELLSIH-----QKKVCEERKAQIAFNEELSRQKLVEEQM 200
E+L+++ E L ++ ++H KK E+ + EE+ R+ + +
Sbjct: 1341 ---FREQLEEE-EEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEG 1396
Query: 201 FSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSI----KAQRQATQLLKEEEA 256
S+ EE A +K E + R Q+EL ++ + L+ Q S K Q++ QLL EE+
Sbjct: 1397 LSQRHEEKVAAYDKLEKTKTRLQQEL-DDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKT 1455
Query: 257 RLVESNNAQIKHENEQDMLKKQKAKQETRTI-LQKALQE------RIEHIQQEYRDEQDL 309
K+ E+D + + ++ET+ + L +AL+E +E + +++R E +
Sbjct: 1456 -------ISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMED 1508
Query: 310 NMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLA---QRREEEK--------AQEK 358
M + + E +K K+ E + E K + L Q E+ K A +
Sbjct: 1509 LMSSKDDVGKSVHE-LEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKA 1567
Query: 359 EFDRILE------EDKAKKLAEKDKELRLEKE-ARRQLVDEVMCTRKLQVQ--------- 402
+F+R L+ E+K K+L + +E+ E E R+Q V +KL++
Sbjct: 1568 QFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHID 1627
Query: 403 -------------EKLQREAKE-----------QEERAMEQKHINESLKELNCEE---KE 435
KLQ + K+ +EE + K + LK + E +E
Sbjct: 1628 SANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQE 1687
Query: 436 NFA---RRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANKMCLDKVQ 488
A R +R AQ+ R +L +IA EEKRR EA +A + L++ Q
Sbjct: 1688 ELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRR-LEARIAQLEEELEEEQ 1742
Score = 73.6 bits (179), Expect = 4e-13
Identities = 108/445 (24%), Positives = 205/445 (46%), Gaps = 66/445 (14%)
Query: 95 EERRNKLRELLALEENEYFTEMQ-LKKETIEEK---KDRMREKTKLLKEKNE-------- 142
EE K+RE EN TEM+ L+ + + EK +++++ +T+L E E
Sbjct: 851 EEELVKVREKQLAAENR-LTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAK 909
Query: 143 KERQDFVAEKLD---QQFRERCEELRVELLSIHQ--KKVCEERKAQIAFNEELSRQKLVE 197
K+ + + L+ ++ ERC+ L+ E + Q +++ E+ + + + ++L +K+
Sbjct: 910 KQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTT 969
Query: 198 EQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEE-- 255
E KL EE+++ E + + A+ +K L + A+ T T L +EEE
Sbjct: 970 EAKLKKL-EEEQIILEDQNCKLAKEKKLLEDRI-----AEFT--------TNLTEEEEKS 1015
Query: 256 ---ARLVESNNAQIKHENEQDMLKKQKAKQE---TRTILQKALQERIEHIQQEYRDEQDL 309
A+L + A I + E+ + +++K +QE TR L+ + + I + +L
Sbjct: 1016 KSLAKLKNKHEAMIT-DLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAEL 1074
Query: 310 NMKL------VQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQ----EKE 359
M+L +Q AL ++EEA +K + IRE + L + E E+A EK+
Sbjct: 1075 KMQLAKKEEELQAALARVEEEAAQKNMALK-KIRELESQISELQEDLESERASRNKAEKQ 1133
Query: 360 FDRILEEDKAKKLAEKD--------KELRLEKEAR----RQLVDEVMCTRKLQVQEKLQR 407
+ EE +A K +D +ELR ++E ++ ++E T + Q+QE Q+
Sbjct: 1134 KRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQK 1193
Query: 408 EAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQ--IAYQQQSQEAE 465
++ EE A + + L ++ R LA E + LQ + ++++ EA+
Sbjct: 1194 HSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQ 1253
Query: 466 KEEKRREFEAGVAANKMCLDKVQEV 490
+E + +F G DKV ++
Sbjct: 1254 LQELQVKFNEGERVRTELADKVTKL 1278
Score = 65.5 bits (158), Expect = 1e-10
Identities = 80/324 (24%), Positives = 149/324 (45%), Gaps = 45/324 (13%)
Query: 189 ELSRQKLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQA- 247
++SRQ EE+M +K E+ L K + + A + ME + L A+ ++ Q QA
Sbjct: 839 QVSRQ---EEEMMAK---EEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAE 892
Query: 248 TQLLKEEE---ARLVESNNA--QIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQE 302
T+L E E ARL +I H+ E + ++++ Q + +K +Q+ I+ ++++
Sbjct: 893 TELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAE-KKKMQQNIQELEEQ 951
Query: 303 YRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDR 362
+E+ KL L+ + EA KK + E +I E + ++ E++ E +
Sbjct: 952 LEEEESARQKL---QLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNL 1008
Query: 363 ILEEDKAKKLAE-KDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKH 421
EE+K+K LA+ K+K E M T ++E+L+RE K+++E ++
Sbjct: 1009 TEEEEKSKSLAKLKNKH-------------EAMIT---DLEERLRREEKQRQELEKTRRK 1052
Query: 422 INESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAGVAANK 481
+ +L+ + E Q +L+MQ+A +E E + E A
Sbjct: 1053 LEGDSTDLSDQIAE--------LQAQIAELKMQLA----KKEEELQAALARVEEEAAQKN 1100
Query: 482 MCLDKVQEVLSTHQVLPQNIHPMR 505
M L K++E+ S L +++ R
Sbjct: 1101 MALKKIRELESQISELQEDLESER 1124
Score = 60.5 bits (145), Expect = 4e-09
Identities = 101/479 (21%), Positives = 200/479 (41%), Gaps = 73/479 (15%)
Query: 44 HQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEERRNKLRE 103
HQ+ +A K + D+L AE + + A+ + E+ K
Sbjct: 1431 HQRQSACNLEKKQKKFDQLLAE----------EKTISAKYAEERDRAEAEAREKETKALS 1480
Query: 104 LL-ALEEN-EYFTEMQ-LKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRER 160
L ALEE E E++ L K+ E +D M K + K +E E+ E+ ++ + +
Sbjct: 1481 LARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQ 1540
Query: 161 CEELRVELLSIHQKKVCEERKAQIA---FNEELSRQKLVEEQMFSKLWEEDRLAKEKREA 217
EEL EL + K+ E Q F +L + E+ +L + R + + E
Sbjct: 1541 LEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVR--EMEAEL 1598
Query: 218 QEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKK 277
++ R+Q+ + R L + ++A + ++E + + AQ+K + L
Sbjct: 1599 EDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRE--LDD 1656
Query: 278 QKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADK-------KKQ 330
+A +E K +++++ ++ E Q+ + +RA + Q+E D+
Sbjct: 1657 TRASREEILAQAKENEKKLKSMEAEMIQLQE-ELAAAERAKRQAQQERDELADEIANSSG 1715
Query: 331 KREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKK----LAEKDKELRLEKE-- 384
K + E++ +AQ EE+ +E++ + L D+ KK + + + +L LE+
Sbjct: 1716 KGALALEEKRRLEARIAQL--EEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHA 1773
Query: 385 -----ARRQL----------VDEVMCTRK--------------LQVQEKLQREAKEQEER 415
AR+QL + E+ T K Q++E+L E KE++
Sbjct: 1774 QKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAA 1833
Query: 416 AMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQIA----YQQQSQEAEKEEKR 470
+ + + LK++ + + +R A++Y+ Q ++Q +EAE+E +R
Sbjct: 1834 CKQVRRTEKKLKDVLLQVDD----ERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQR 1888
Score = 57.4 bits (137), Expect = 3e-08
Identities = 94/442 (21%), Positives = 191/442 (43%), Gaps = 68/442 (15%)
Query: 22 IVRSKPPKGQGAEHHLERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRA 81
++ SK G+ H LE+ +R+ ++ + + D L+A D ++ ++A
Sbjct: 1509 LMSSKDDVGKSV-HELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKA 1567
Query: 82 RIKDAVQGFIINIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLK--- 138
+ + +QG EE++ +L + E E E + + + +K ++ K L+
Sbjct: 1568 QFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARK-KLEMDLKDLEAHI 1626
Query: 139 EKNEKERQDFVAE--KLDQQFRERCEEL------RVELLS---IHQKKVCEERKAQIAFN 187
+ K R + + + KL Q ++ EL R E+L+ ++KK+ I
Sbjct: 1627 DSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQ 1686
Query: 188 EELSRQKLVEEQMFSKLWEEDRLA----------------KEKREAQEARRQKELMENTR 231
EEL+ + + Q E D LA K + EA+ A+ ++EL E
Sbjct: 1687 EELAAAERAKRQAQQ---ERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQG 1743
Query: 232 LGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKA 291
N ++ + + ++ Q+ + +E ++AQ K+EN + L++Q K
Sbjct: 1744 ---NTELINDRLKKANLQIDQINTDLNLERSHAQ-KNENARQQLERQ----------NKE 1789
Query: 292 LQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRRE 351
L+ +++ ++ + + ++ ++ + L+E+ D + ++R+ ++ RR
Sbjct: 1790 LKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQ---------VRRT 1840
Query: 352 EEKAQEKEFDRILEEDKAKKLAEK-----DKELRLEKEARRQLVD-EVMCTRKLQVQEKL 405
E+K + D +L+ D ++ AE+ DK K+ +RQL + E R + KL
Sbjct: 1841 EKKLK----DVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKL 1896
Query: 406 QREAKEQEERAMEQKHINESLK 427
QRE ++ E A SLK
Sbjct: 1897 QRELEDATETADAMNREVSSLK 1918
Score = 40.0 bits (92), Expect = 0.005
Identities = 49/211 (23%), Positives = 103/211 (48%), Gaps = 18/211 (8%)
Query: 274 MLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKRE 333
+ +K AK++ + K LQ + R+ Q + + L + + ++ K E
Sbjct: 794 LARKAFAKRQQQLTAMKVLQRNCA-AYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEE 852
Query: 334 DMIREQKIYHKYLAQRR---EEEKAQEK---EFDRILEEDKAK-KLAEKDKELRLEKEAR 386
+++ K+ K LA E E Q + E ++ E+ +A+ +L + +ELR A+
Sbjct: 853 ELV---KVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAK 909
Query: 387 RQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQ- 445
+Q ++E+ + +V+E+ +R Q E+ Q++I E ++L EE+E+ ++ +L +
Sbjct: 910 KQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQL--EEEESARQKLQLEKV 967
Query: 446 ----EYRKQLQMQIAYQQQSQEAEKEEKRRE 472
+ +K + QI + Q+ + KE+K E
Sbjct: 968 TTEAKLKKLEEEQIILEDQNCKLAKEKKLLE 998
Score = 32.7 bits (73), Expect = 0.81
Identities = 39/167 (23%), Positives = 76/167 (45%), Gaps = 33/167 (19%)
Query: 346 LAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKL 405
++++ EE A+E+E ++ E K+LA +++ +E + QL+ E KLQ+QE+L
Sbjct: 840 VSRQEEEMMAKEEELVKVRE----KQLAAENRLTEMET-LQSQLMAE-----KLQLQEQL 889
Query: 406 QREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAE 465
Q E + C E E R RL +KQ +I + +++ E
Sbjct: 890 QAETEL-------------------CAEAEEL--RARLTA--KKQELEEICHDLEARVEE 926
Query: 466 KEEKRREFEAGVAANKMCLDKVQEVLSTHQVLPQNIHPMRKACPSKL 512
+EE+ + +A + + +++E L + Q + + +KL
Sbjct: 927 EEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKL 973
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 87.4 bits (215), Expect = 3e-17
Identities = 87/387 (22%), Positives = 175/387 (45%), Gaps = 23/387 (5%)
Query: 102 RELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQ-DFVAEKLDQQFRER 160
RE +E E E + + + K++R REK + K +ERQ D E+ Q RER
Sbjct: 54 RERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRER 113
Query: 161 CEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKEKREAQEA 220
+ E +++ ER+ + + + Q+ E Q ++ E + +E++ E
Sbjct: 114 DRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTER 173
Query: 221 RRQKEL---------MENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENE 271
RQKE E R T + + + +E E Q E +
Sbjct: 174 NRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERD 233
Query: 272 -QDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQ 330
Q ++++ KQ R + ER + ++E ++D + + +R + + D+K+Q
Sbjct: 234 RQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKER-----ERQTDRKRQ 288
Query: 331 KREDMIRE-QKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQL 389
+R + RE ++ + + RE E+ +++E +R E ++ ++ E +++ E+E +R+
Sbjct: 289 RRTERDRETERKRERQRERERERERNRKRERERERERERERQ-RETERDREKERERKRKR 347
Query: 390 VDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRK 449
E+ R Q + +R+A+ + ER E++ +S +E E++ RQ+ E +
Sbjct: 348 QTEMDRERNRQTGREGRRQAERERER--ERERDRQSAREREERERDRDRDRQK---ERER 402
Query: 450 QLQMQIAYQQQSQEAEKEEKRREFEAG 476
Q + Q+++++ + EK RE E G
Sbjct: 403 QTEKDRDGQRETEKQREREKDRESERG 429
Score = 78.2 bits (191), Expect = 2e-14
Identities = 88/422 (20%), Positives = 186/422 (44%), Gaps = 42/422 (9%)
Query: 34 EHHLERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIIN 93
+ H +R R ++ + + ++R+R + + N K + R ++ +G
Sbjct: 86 DRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERE---RETEREGERGRDRQ 142
Query: 94 IEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKL 153
+ +R + R+ A +E E T+ + +++T E + + RE+ K +E+ E+ERQ K
Sbjct: 143 TDGQRERERQRDAEKERERQTDRERQRQT-ERNRQKEREREKNRQERRERERQREKENKT 201
Query: 154 DQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKE 213
+ + ER E E + + ERK Q + E RQ+ E + E + +E
Sbjct: 202 EDRHSERGRERERE----RETETETERKRQT--DRERDRQRKTERE------REKQAERE 249
Query: 214 KREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQD 273
+ +E R KE E R R + KE E + + + + E +
Sbjct: 250 RASERETERDKE-RERER----------DRDRDRDRRQKERERQTDRKRQRRTERDRETE 298
Query: 274 MLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKRE 333
++++ ++E +ER + ++E E++ + + +D ++E ++K++++
Sbjct: 299 RKRERQRERE---------RERERNRKRERERERERERERQRETERDREKERERKRKRQT 349
Query: 334 DMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEV 393
+M RE+ RR+ E+ +E+E +R + + ++ E+D++ +KE RQ +
Sbjct: 350 EMDRERN-RQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDR 408
Query: 394 MCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQM 453
R+ + Q +RE + ER E+ E K E++ + R A RK+ +
Sbjct: 409 DGQRETEKQR--EREKDRESERGRERGREREKQKG---RERDRERQTDRQAGRQRKRSTL 463
Query: 454 QI 455
+
Sbjct: 464 YV 465
Score = 44.7 bits (104), Expect = 2e-04
Identities = 36/154 (23%), Positives = 78/154 (50%), Gaps = 9/154 (5%)
Query: 323 EEADKKKQKREDMIREQKIYHKYLAQRRE--EEKAQEKEFDRILEEDKAKKLAEKDKELR 380
++ ++ +QK + RE++ + ++RE EK + ++ DR E + + EK++E +
Sbjct: 52 DDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDR---EKERERQ 108
Query: 381 LEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCEEKENFARR 440
++E RQ E R+ + + + +RE + +R + + E ++ +E+E R
Sbjct: 109 TDRERDRQREKE--RNRQKERERETEREGERGRDRQTDGQRERERQRDAE-KERERQTDR 165
Query: 441 QRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFE 474
+R Q R + Q + ++ QE + E++RE E
Sbjct: 166 ERQRQTERNR-QKEREREKNRQERRERERQREKE 198
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 87.4 bits (215), Expect = 3e-17
Identities = 83/353 (23%), Positives = 188/353 (53%), Gaps = 36/353 (10%)
Query: 135 KLLKEKNEKERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQK 194
KL KE++ + + D++ +E+ EL+ +L ++ E K++I N + ++K
Sbjct: 194 KLTKERDAPSLELYRNTITDEELKEKNAELQEKL------RLVESEKSEIQLNVKDLKRK 247
Query: 195 LVEEQMFSKLW----EEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQL 250
L Q+ E DRL KE + A+ Q ++ EN L Q K RQ ++
Sbjct: 248 LERAQLLLPQQQLQVEADRLGKELQSVS-AKLQAQVEENELWNLLNQQQEEKMWRQEEKI 306
Query: 251 LKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKA-----LQERIEHIQQEYRD 305
+E+E ++ E +I+ + E+ +++K ++ I ++ +E+I +++ R+
Sbjct: 307 -QEQEEKMCEQE-LKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIRE 364
Query: 306 EQDLNMKLVQRALQDLQEEADKKKQKREDMIR-EQKIYHKYLAQRREEEKAQEK---EFD 361
+++ + R + ++E+ +K +++ E+M R E+KI R +EEK QEK +
Sbjct: 365 QEEK----MWRQEEKIREQDEKIQEQEEEMWRQEEKI-------REQEEKRQEKMWRQEK 413
Query: 362 RILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKH 421
++ E+D +K+ E+++E+ ++E R+L +E+M ++ +++E ++ +E+E+ +++
Sbjct: 414 KMREQD--EKIREQEEEMWRQEEKIREL-EEMMQDQEEKLREVEEKMQEEEEKMQEQEEK 470
Query: 422 INESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFE 474
I +++ +E++ + + + L QE + Q + ++Q+ + E+EEK +E E
Sbjct: 471 IQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQE 523
Score = 84.7 bits (208), Expect = 2e-16
Identities = 89/401 (22%), Positives = 198/401 (49%), Gaps = 47/401 (11%)
Query: 93 NIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEK 152
++E RN + + E+N E+Q K +E +K ++ K LK K E+ A+
Sbjct: 203 SLELYRNTITDEELKEKN---AELQEKLRLVESEKSEIQLNVKDLKRKLER------AQL 253
Query: 153 L--DQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRL 210
L QQ + + L EL S+ K +AQ+ NE + L+ +Q K+W ++
Sbjct: 254 LLPQQQLQVEADRLGKELQSVSAKL-----QAQVEENELWN---LLNQQQEEKMWRQEEK 305
Query: 211 AKEKREAQ-----EARRQKELMENTRLGLNAQITSIKAQR----QATQLLKEEEARLVES 261
+E+ E + R Q+E M ++ Q I+ Q + + ++E+E +
Sbjct: 306 IQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEK---- 361
Query: 262 NNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDL 321
I+ + E+ +++K +++ I ++ +E + +++ R++++ + + R + +
Sbjct: 362 ----IREQEEKMWRQEEKIREQDEKIQEQ--EEEMWRQEEKIREQEEKRQEKMWRQEKKM 415
Query: 322 QEEADKKKQKREDMIR-EQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELR 380
+E+ +K +++ E+M R E+KI + +EEK +E E +++ EE+ +K+ E++++++
Sbjct: 416 REQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVE-EKMQEEE--EKMQEQEEKIQ 472
Query: 381 LEKEARRQLVDEVMCTRKLQVQEKLQREAKE----QEERAMEQKH-INESLKELNCEEKE 435
++E ++ ++ KL QE+ E +E QEE+ EQ+ + E +++ +E++
Sbjct: 473 RQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEK 532
Query: 436 NFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAG 476
+ RL Q+ K + ++ Q+ + K ++ E G
Sbjct: 533 MREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGG 573
Score = 74.7 bits (182), Expect = 2e-13
Identities = 74/350 (21%), Positives = 179/350 (51%), Gaps = 29/350 (8%)
Query: 92 INIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKE-RQDFVA 150
+ + N+L LL ++ E +M ++E I+E++++M E+ ++E+ EK RQ+
Sbjct: 278 LQAQVEENELWNLLNQQQEE---KMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKM 334
Query: 151 EKLDQQFRERCEEL--RVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEED 208
+ +++ RE+ +++ + E + ++K+ E+ + E++ Q ++ ++W ++
Sbjct: 335 HEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQE 394
Query: 209 RLAKEKREAQEAR--RQKELMENTRLGLNAQITSIKAQ----RQATQLLKEEEARLVE-- 260
+E+ E ++ + RQ++ M + Q + Q R+ ++++++E +L E
Sbjct: 395 EKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVE 454
Query: 261 --SNNAQIKHENEQDMLKKQKAK---QETRTILQKALQERIEHIQQEYRDEQDLNMKLVQ 315
+ K + +++ +++Q+ K QE +T Q+ L ++ E I ++ K+ +
Sbjct: 455 EKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWE 514
Query: 316 RALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEK 375
+ ++ +E ++K Q++E+ +REQ++ ++EEK QE+E E++ KL +K
Sbjct: 515 Q--EEKMQEQEEKMQRQEEKMREQEV-----RLWQQEEKMQEQEVRLQELEERLGKLGQK 567
Query: 376 DKEL-RLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINE 424
+ L +E+ Q + + T LQV+ K Q Q+++ + H+ +
Sbjct: 568 AELLGGAGRESGSQRLPTL--TPILQVELKSQEAQSLQQQQDHYRGHLQQ 615
Score = 65.1 bits (157), Expect = 1e-10
Identities = 95/419 (22%), Positives = 194/419 (46%), Gaps = 50/419 (11%)
Query: 110 NEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRERCEELRVELL 169
+E F ++ + +E +K R ++ + E E E L + ++ +E
Sbjct: 60 DEKFFQLSEMEAYLENRKRRGTKRWDEDDDLEESEDSKQCKESLKRVTFTLPDDEAIEDA 119
Query: 170 SI-HQKKVCEE-----RKAQIAFNEE--LSRQKLVEEQMFSKLWE-------EDRLAKEK 214
+ H KK +E +K Q NE+ R+++V ++ + +L E E+ L +E
Sbjct: 120 GVSHVKKNSDEVKSSFKKRQEKMNEKNYTFRKRVVIKKPWLRLGEVTAQKRPENSLLEET 179
Query: 215 REAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEA------RLVESNNAQIKH 268
A R +E +A + + LKE+ A RLVES ++I+
Sbjct: 180 LHFDHAVRMGTYIEKLTKERDAPSLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQ- 238
Query: 269 ENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQD-----LQE 323
N +D+ K+K ++ + Q+ LQ + + +E Q ++ KL + ++ L +
Sbjct: 239 LNVKDL--KRKLERAQLLLPQQQLQVEADRLGKEL---QSVSAKLQAQVEENELWNLLNQ 293
Query: 324 EADKKKQKREDMIREQ--KIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRL 381
+ ++K ++E+ I+EQ K+ + L R +EEK +E +E+K ++ ++DK R
Sbjct: 294 QQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIRE--QEDKMWRQ 351
Query: 382 EKEARRQLVDEVMCTRKLQVQE----KLQREAKEQEERAMEQKHINESLKELNCEEKENF 437
E++ R Q K++ QE + + + +EQ+E+ EQ+ +E E++E
Sbjct: 352 EEKIREQ-------EEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEK- 403
Query: 438 ARRQRLAQEYRKQLQMQIAYQQQSQEA-EKEEKRREFEAGVAANKMCLDKVQEVLSTHQ 495
R++++ ++ +K + ++Q +E +EEK RE E + + L +V+E + +
Sbjct: 404 -RQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEE 461
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 87.0 bits (214), Expect = 4e-17
Identities = 83/353 (23%), Positives = 188/353 (53%), Gaps = 36/353 (10%)
Query: 135 KLLKEKNEKERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQK 194
KL KE++ + + D++ +E+ EL+ +L ++ E K++I N + ++K
Sbjct: 194 KLTKERDALSLELYRNTITDEELKEKNAELQEKL------RLVESEKSEIQLNVKDLKRK 247
Query: 195 LVEEQMFSKLW----EEDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQL 250
L Q+ E DRL KE + A+ Q ++ EN L Q K RQ ++
Sbjct: 248 LERAQLLLPQQQLQVEADRLGKELQSVS-AKLQAQVEENELWNLLNQQQEEKMWRQEEKI 306
Query: 251 LKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKA-----LQERIEHIQQEYRD 305
+E+E ++ E +I+ + E+ +++K ++ I ++ +E+I +++ R+
Sbjct: 307 -QEQEEKMCEQE-LKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIRE 364
Query: 306 EQDLNMKLVQRALQDLQEEADKKKQKREDMIR-EQKIYHKYLAQRREEEKAQEK---EFD 361
+++ + R + ++E+ +K +++ E+M R E+KI R +EEK QEK +
Sbjct: 365 QEEK----MWRQEEKIREQDEKIQEQEEEMWRQEEKI-------REQEEKRQEKMWRQEK 413
Query: 362 RILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKH 421
++ E+D +K+ E+++E+ ++E R+L +E+M ++ +++E ++ +E+E+ +++
Sbjct: 414 KMREQD--EKIREQEEEMWRQEEKIREL-EEMMQDQEEKLREVEEKMQEEEEKMQEQEEK 470
Query: 422 INESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFE 474
I +++ +E++ + + + L QE + Q + ++Q+ + E+EEK +E E
Sbjct: 471 IQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQE 523
Score = 85.5 bits (210), Expect = 1e-16
Identities = 89/402 (22%), Positives = 199/402 (49%), Gaps = 47/402 (11%)
Query: 92 INIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAE 151
+++E RN + + E+N E+Q K +E +K ++ K LK K E+ A+
Sbjct: 202 LSLELYRNTITDEELKEKN---AELQEKLRLVESEKSEIQLNVKDLKRKLER------AQ 252
Query: 152 KL--DQQFRERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDR 209
L QQ + + L EL S+ K +AQ+ NE + L+ +Q K+W ++
Sbjct: 253 LLLPQQQLQVEADRLGKELQSVSAKL-----QAQVEENELWN---LLNQQQEEKMWRQEE 304
Query: 210 LAKEKREAQ-----EARRQKELMENTRLGLNAQITSIKAQR----QATQLLKEEEARLVE 260
+E+ E + R Q+E M ++ Q I+ Q + + ++E+E +
Sbjct: 305 KIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEK--- 361
Query: 261 SNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQD 320
I+ + E+ +++K +++ I ++ +E + +++ R++++ + + R +
Sbjct: 362 -----IREQEEKMWRQEEKIREQDEKIQEQ--EEEMWRQEEKIREQEEKRQEKMWRQEKK 414
Query: 321 LQEEADKKKQKREDMIR-EQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKEL 379
++E+ +K +++ E+M R E+KI + +EEK +E E +++ EE+ +K+ E+++++
Sbjct: 415 MREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVE-EKMQEEE--EKMQEQEEKI 471
Query: 380 RLEKEARRQLVDEVMCTRKLQVQEKLQREAKE----QEERAMEQKH-INESLKELNCEEK 434
+ ++E ++ ++ KL QE+ E +E QEE+ EQ+ + E +++ +E+
Sbjct: 472 QRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEE 531
Query: 435 ENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEAG 476
+ + RL Q+ K + ++ Q+ + K ++ E G
Sbjct: 532 KMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGG 573
Score = 74.7 bits (182), Expect = 2e-13
Identities = 74/350 (21%), Positives = 179/350 (51%), Gaps = 29/350 (8%)
Query: 92 INIEERRNKLRELLALEENEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKE-RQDFVA 150
+ + N+L LL ++ E +M ++E I+E++++M E+ ++E+ EK RQ+
Sbjct: 278 LQAQVEENELWNLLNQQQEE---KMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKM 334
Query: 151 EKLDQQFRERCEEL--RVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEED 208
+ +++ RE+ +++ + E + ++K+ E+ + E++ Q ++ ++W ++
Sbjct: 335 HEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQE 394
Query: 209 RLAKEKREAQEAR--RQKELMENTRLGLNAQITSIKAQ----RQATQLLKEEEARLVE-- 260
+E+ E ++ + RQ++ M + Q + Q R+ ++++++E +L E
Sbjct: 395 EKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVE 454
Query: 261 --SNNAQIKHENEQDMLKKQKAK---QETRTILQKALQERIEHIQQEYRDEQDLNMKLVQ 315
+ K + +++ +++Q+ K QE +T Q+ L ++ E I ++ K+ +
Sbjct: 455 EKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWE 514
Query: 316 RALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEK 375
+ ++ +E ++K Q++E+ +REQ++ ++EEK QE+E E++ KL +K
Sbjct: 515 Q--EEKMQEQEEKMQRQEEKMREQEV-----RLWQQEEKMQEQEVRLQELEERLGKLGQK 567
Query: 376 DKEL-RLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINE 424
+ L +E+ Q + + T LQV+ K Q Q+++ + H+ +
Sbjct: 568 AELLGGAGRESGSQRLPTL--TPILQVELKSQEAQSLQQQQDHYRGHLQQ 615
Score = 64.7 bits (156), Expect = 2e-10
Identities = 95/419 (22%), Positives = 194/419 (46%), Gaps = 50/419 (11%)
Query: 110 NEYFTEMQLKKETIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRERCEELRVELL 169
+E F ++ + +E +K R ++ + E E E L + ++ +E
Sbjct: 60 DEKFFQLSEMEAYLENRKRRGTKRWDEDDDLEESEDSKQCKESLKRVTFTLPDDEAIEDA 119
Query: 170 SI-HQKKVCEE-----RKAQIAFNEE--LSRQKLVEEQMFSKLWE-------EDRLAKEK 214
+ H KK +E +K Q NE+ R+++V ++ + +L E E+ L +E
Sbjct: 120 GVSHVKKNSDEVKSSFKKRQEKMNEKNYTFRKRVVIKKPWLRLGEVTAQKRPENSLLEET 179
Query: 215 REAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEA------RLVESNNAQIKH 268
A R +E +A + + LKE+ A RLVES ++I+
Sbjct: 180 LHFDHAVRMGTYIEKLTKERDALSLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQ- 238
Query: 269 ENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQD-----LQE 323
N +D+ K+K ++ + Q+ LQ + + +E Q ++ KL + ++ L +
Sbjct: 239 LNVKDL--KRKLERAQLLLPQQQLQVEADRLGKEL---QSVSAKLQAQVEENELWNLLNQ 293
Query: 324 EADKKKQKREDMIREQ--KIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELRL 381
+ ++K ++E+ I+EQ K+ + L R +EEK +E +E+K ++ ++DK R
Sbjct: 294 QQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIRE--QEDKMWRQ 351
Query: 382 EKEARRQLVDEVMCTRKLQVQE----KLQREAKEQEERAMEQKHINESLKELNCEEKENF 437
E++ R Q K++ QE + + + +EQ+E+ EQ+ +E E++E
Sbjct: 352 EEKIREQ-------EEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEK- 403
Query: 438 ARRQRLAQEYRKQLQMQIAYQQQSQEA-EKEEKRREFEAGVAANKMCLDKVQEVLSTHQ 495
R++++ ++ +K + ++Q +E +EEK RE E + + L +V+E + +
Sbjct: 404 -RQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEE 461
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.127 0.334
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,072,044
Number of Sequences: 37866
Number of extensions: 900663
Number of successful extensions: 27887
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 546
Number of HSP's successfully gapped in prelim test: 1396
Number of HSP's that attempted gapping in prelim test: 6433
Number of HSP's gapped (non-prelim): 8353
length of query: 514
length of database: 18,247,518
effective HSP length: 107
effective length of query: 407
effective length of database: 14,195,856
effective search space: 5777713392
effective search space used: 5777713392
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.