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Search of human proteins with 94536854
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|94536854 thrombospondin, type I, domain containing 4 [Homo
sapiens]
(1018 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|94536854 thrombospondin, type I, domain containing 4 [Homo sa... 2174 0.0
gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo s... 697 0.0
gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo s... 481 e-135
gi|124430557 a disintegrin-like and metalloprotease with thrombo... 320 6e-87
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo... 307 4e-83
gi|33624896 ADAM metallopeptidase with thrombospondin type 1 mot... 305 2e-82
gi|40806187 ADAM metallopeptidase with thrombospondin type 1 mot... 303 4e-82
gi|64276808 ADAM metallopeptidase with thrombospondin type 1 mot... 302 9e-82
gi|56121815 ADAM metallopeptidase with thrombospondin type 1 mot... 266 7e-71
gi|223718260 ADAMTS-like 2 precursor [Homo sapiens] 236 6e-62
gi|41281450 ADAMTS-like 2 precursor [Homo sapiens] 236 6e-62
gi|169174934 PREDICTED: similar to ADAMTS-like 2 [Homo sapiens] 236 6e-62
gi|38683827 ADAM metallopeptidase with thrombospondin type 1 mot... 232 1e-60
gi|145309328 papilin [Homo sapiens] 228 2e-59
gi|112789555 ADAM metallopeptidase with thrombospondin type 1 mo... 217 5e-56
gi|51558724 ADAM metallopeptidase with thrombospondin type 1 mot... 197 5e-50
gi|21265037 ADAM metallopeptidase with thrombospondin type 1 mot... 185 2e-46
gi|226442878 ADAMTS-like 5 [Homo sapiens] 184 3e-46
gi|110611170 ADAM metallopeptidase with thrombospondin type 1 mo... 181 3e-45
gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens] 179 9e-45
gi|21265058 a disintegrin-like and metalloprotease (reprolysin t... 179 2e-44
gi|145275198 ADAMTS-like 3 precursor [Homo sapiens] 176 8e-44
gi|21265052 ADAM metallopeptidase with thrombospondin type 1 mot... 166 8e-41
gi|110611167 ADAM metallopeptidase with thrombospondin type 1 mo... 166 8e-41
gi|110825974 ADAM metallopeptidase with thrombospondin type 1 mo... 164 5e-40
gi|50845384 ADAM metallopeptidase with thrombospondin type 1 mot... 147 5e-35
gi|153792351 ADAM metallopeptidase with thrombospondin type 1 mo... 139 1e-32
gi|195539372 ADAM metallopeptidase with thrombospondin type 1 mo... 136 9e-32
gi|157427675 ADAM metallopeptidase with thrombospondin type 1 mo... 134 6e-31
gi|21265043 ADAM metallopeptidase with thrombospondin type 1 mot... 130 8e-30
>gi|94536854 thrombospondin, type I, domain containing 4 [Homo
sapiens]
Length = 1018
Score = 2174 bits (5634), Expect = 0.0
Identities = 1018/1018 (100%), Positives = 1018/1018 (100%)
Query: 1 MVSHFMGSLSVLCFLLLLGFQFVCPQPSTQHRKVPQRMAAEGAPEDDGGGGAPGVWGAWG 60
MVSHFMGSLSVLCFLLLLGFQFVCPQPSTQHRKVPQRMAAEGAPEDDGGGGAPGVWGAWG
Sbjct: 1 MVSHFMGSLSVLCFLLLLGFQFVCPQPSTQHRKVPQRMAAEGAPEDDGGGGAPGVWGAWG 60
Query: 61 PWSACSRSCSGGVMEQTRPCLPRSYRLRGGQRPGAPARAFADHVVSAVRTSVPLHRSRDE 120
PWSACSRSCSGGVMEQTRPCLPRSYRLRGGQRPGAPARAFADHVVSAVRTSVPLHRSRDE
Sbjct: 61 PWSACSRSCSGGVMEQTRPCLPRSYRLRGGQRPGAPARAFADHVVSAVRTSVPLHRSRDE 120
Query: 121 TPALAGTDASRQGPTVLRGSRHPQPQGLEVTGDRRSRTRGTIGPGKYGYGKAPYILPLQT 180
TPALAGTDASRQGPTVLRGSRHPQPQGLEVTGDRRSRTRGTIGPGKYGYGKAPYILPLQT
Sbjct: 121 TPALAGTDASRQGPTVLRGSRHPQPQGLEVTGDRRSRTRGTIGPGKYGYGKAPYILPLQT 180
Query: 181 DTAHTPQRLRRQKLSSRHSRSQGASSARHGYSSPAHQVPQHGPLYQSDSGPRSGLQAAEA 240
DTAHTPQRLRRQKLSSRHSRSQGASSARHGYSSPAHQVPQHGPLYQSDSGPRSGLQAAEA
Sbjct: 181 DTAHTPQRLRRQKLSSRHSRSQGASSARHGYSSPAHQVPQHGPLYQSDSGPRSGLQAAEA 240
Query: 241 PIYQLPLTHDQGYPAASSLFHSPETSNNHGVGTHGATQSFSQPARSTAISCIGAYRQYKL 300
PIYQLPLTHDQGYPAASSLFHSPETSNNHGVGTHGATQSFSQPARSTAISCIGAYRQYKL
Sbjct: 241 PIYQLPLTHDQGYPAASSLFHSPETSNNHGVGTHGATQSFSQPARSTAISCIGAYRQYKL 300
Query: 301 CNTNVCPESSRSIREVQCASYNNKPFMGRFYEWEPFAEVKGNRKCELNCQAMGYRFYVRQ 360
CNTNVCPESSRSIREVQCASYNNKPFMGRFYEWEPFAEVKGNRKCELNCQAMGYRFYVRQ
Sbjct: 301 CNTNVCPESSRSIREVQCASYNNKPFMGRFYEWEPFAEVKGNRKCELNCQAMGYRFYVRQ 360
Query: 361 AEKVIDGTPCDQNGTAICVSGQCKSIGCDDYLGSDKVVDKCGVCGGDNTGCQVVSGVFKH 420
AEKVIDGTPCDQNGTAICVSGQCKSIGCDDYLGSDKVVDKCGVCGGDNTGCQVVSGVFKH
Sbjct: 361 AEKVIDGTPCDQNGTAICVSGQCKSIGCDDYLGSDKVVDKCGVCGGDNTGCQVVSGVFKH 420
Query: 421 ALTSLGYHRVVEIPEGATKINITEMYKSNNYLALRSRSGRSIINGNWAIDRPGKYEGGGT 480
ALTSLGYHRVVEIPEGATKINITEMYKSNNYLALRSRSGRSIINGNWAIDRPGKYEGGGT
Sbjct: 421 ALTSLGYHRVVEIPEGATKINITEMYKSNNYLALRSRSGRSIINGNWAIDRPGKYEGGGT 480
Query: 481 MFTYKRPNEISSTAGESFLAEGPTNEILDVYMIHQQPNPGVHYEYVIMGTNAISPQVPPH 540
MFTYKRPNEISSTAGESFLAEGPTNEILDVYMIHQQPNPGVHYEYVIMGTNAISPQVPPH
Sbjct: 481 MFTYKRPNEISSTAGESFLAEGPTNEILDVYMIHQQPNPGVHYEYVIMGTNAISPQVPPH 540
Query: 541 RRPGEPFNGQMVTEGRSQEEGEQKGRNEEKEDLRGEAPEMFTSESAQTFPVRHPDRFSPH 600
RRPGEPFNGQMVTEGRSQEEGEQKGRNEEKEDLRGEAPEMFTSESAQTFPVRHPDRFSPH
Sbjct: 541 RRPGEPFNGQMVTEGRSQEEGEQKGRNEEKEDLRGEAPEMFTSESAQTFPVRHPDRFSPH 600
Query: 601 RPDNLVPPAPQPPRRSRDHNWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDS 660
RPDNLVPPAPQPPRRSRDHNWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDS
Sbjct: 601 RPDNLVPPAPQPPRRSRDHNWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDS 660
Query: 661 SMKPTPEEEPCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQ 720
SMKPTPEEEPCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQ
Sbjct: 661 SMKPTPEEEPCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQ 720
Query: 721 HLEKPETTSTCQLKICSEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKL 780
HLEKPETTSTCQLKICSEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKL
Sbjct: 721 HLEKPETTSTCQLKICSEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKL 780
Query: 781 RPNDIENCDMGPCAKSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNNRPA 840
RPNDIENCDMGPCAKSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNNRPA
Sbjct: 781 RPNDIENCDMGPCAKSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNNRPA 840
Query: 841 EATPCDNGPCTGKVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEK 900
EATPCDNGPCTGKVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEK
Sbjct: 841 EATPCDNGPCTGKVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEK 900
Query: 901 PPSQQSCHLKPCGAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERE 960
PPSQQSCHLKPCGAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERE
Sbjct: 901 PPSQQSCHLKPCGAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERE 960
Query: 961 SCNPQDCVPEVDENCKDKYYNCNVVVQARLCVYNYYKTACCASCTRVANRQTGFLGSR 1018
SCNPQDCVPEVDENCKDKYYNCNVVVQARLCVYNYYKTACCASCTRVANRQTGFLGSR
Sbjct: 961 SCNPQDCVPEVDENCKDKYYNCNVVVQARLCVYNYYKTACCASCTRVANRQTGFLGSR 1018
>gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo
sapiens]
Length = 1074
Score = 697 bits (1800), Expect = 0.0
Identities = 403/1060 (38%), Positives = 533/1060 (50%), Gaps = 129/1060 (12%)
Query: 49 GGGAPGVWGAWGPWSACSRSCSGGVMEQTRPCL-------------------PRSYRLRG 89
G G GVWG W W++CS+ C GV ++R C P + RG
Sbjct: 40 GQGPEGVWGPWVQWASCSQPCGVGVQRRSRTCQLPTVQLHPSLPLPPRPPRHPEALLPRG 99
Query: 90 -GQRP-----------------GAPARAFADHV-------VSAVRTS------------- 111
G RP G P R A H+ + A R S
Sbjct: 100 QGPRPQTSPETLPLYRTQSRGRGGPLRGPASHLGREETQEIRAARRSRLRDPIKPGMFGY 159
Query: 112 ------VPLHRSRDETPALAGTDASRQGPTVLRGSRHPQPQGLEVTGDRRSRTRGTIGPG 165
+PLHR+R + ++ S P P+ + + +T + P
Sbjct: 160 GRVPFALPLHRNRRHPRSPPRSELSLISSRGEEAIPSPTPRAEPFSANGSPQTE--LPPT 217
Query: 166 KYG-YGKAPYILPLQTDTAHTPQRLRRQKLSSRHSRSQGASSARHGYSSPAHQVPQHG-- 222
+ + +P PL +TA T R + RH AS SP H + + G
Sbjct: 218 ELSVHTPSPQAEPLSPETAQTEVAPRTRPAPLRHHPRAQASGTEP--PSPTHSLGEGGFF 275
Query: 223 -----PLYQSDSGPRSGLQAAEAP--IYQLPL---THDQGYPAASSLFHSP--ETSNNH- 269
P S G S A P +P QG H P E H
Sbjct: 276 RASPQPRRPSSQGWASPQVAGRRPDPFPSVPRGRGQQGQGPWGTGGTPHGPRLEPDPQHP 335
Query: 270 -------GVGTHGATQSFSQPARSTAIS-CIGAYRQYKLCNTNVCPESSRSIREVQCASY 321
G H A+ +S A S+ I C G Q + C+ CP R +QCA++
Sbjct: 336 GAWLPLLSNGPH-ASSLWSLFAPSSPIPRCSGESEQLRACSQAPCPPEQPDPRALQCAAF 394
Query: 322 NNKPFMGRFYEWEPFAEVKGNRKCELNCQAMGYRFYVRQAEKVIDGTPCDQNGTAICVSG 381
N++ FMG+ Y+WEPF EV+G+++CELNC+ G+RFYVR EKV DGT C ICV+G
Sbjct: 395 NSQEFMGQLYQWEPFTEVQGSQRCELNCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAG 454
Query: 382 QCKSIGCDDYLGSDKVVDKCGVCGGDNTGCQVVSGVFKHALTSLGYHRVVEIPEGATKIN 441
+C S GCD LGS + D CGVCGGD++ C++VSG LGY +++ IP GA ++
Sbjct: 455 RCLSPGCDGILGSGRRPDGCGVCGGDDSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQ 514
Query: 442 ITEMYKSNNYLALRSRSGRSIINGNWAIDRPGKYEGGGTMFTYKRPNEISSTAGESFLAE 501
I ++ S+NYLALR GRSIINGNWA+D PG Y GGT+F Y RP GES AE
Sbjct: 515 IAQLRPSSNYLALRGPGGRSIINGNWAVDPPGSYRAGGTVFRYNRPPR-EEGKGESLSAE 573
Query: 502 GPTNEILDVYMIHQQPNPGVHYEYVIMGTNAISPQVPPHRRPGEPFNGQMVTEGRSQEEG 561
GPT + +DVYMI Q+ NPGV Y+YVI I P EP Q+
Sbjct: 574 GPTTQPVDVYMIFQEENPGVFYQYVISSPPPILENPTP-----EPPVPQL---------- 618
Query: 562 EQKGRNEEKEDLRGEAPEMFTSESAQTFPVRHPDRFSPHRPDNLVPPAPQPPRRSRDHNW 621
+ E LR E P A+T P P PP P+ P S W
Sbjct: 619 -------QPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMP---APPHPRTPLGSPAAYW 668
Query: 622 KQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPCPAFWD 681
K++G + CS +CGKG PIF C+ R + EE E C + +P EPC+ PCP +W+
Sbjct: 669 KRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYWE 728
Query: 682 IGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKICSEWQI 741
GEW+ CS++CG G QHRQ+ CRQ + +V P RC HL +P T +CQL++C W++
Sbjct: 729 AGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWEV 788
Query: 742 RTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEEC-NMKLRPNDIENCDMGPCAKSWFLT 800
+ W+ CSV CG GQR+R V+CV N GD V ++EC + +P E CDMGPC +WF +
Sbjct: 789 GSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFHS 848
Query: 801 EWSERCSAECGAGVRTRSVVCMTNHVSSLPLEG---------C-GNNRPAEATPCDNGPC 850
+WS +CSAECG G++ RSVVC+ + + P +G C +RP + C GPC
Sbjct: 849 DWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLGPC 908
Query: 851 TGKVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLK 910
W+ G W +CS ECGSGTQ+R++ICV K F V PS CS L +PP+ Q C +
Sbjct: 909 ERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQGQ 968
Query: 911 PCGAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERESCNPQDCVPE 970
C +WFST WS CS+SCQGG + REV+CLS + TLS C PQL+P + CN Q C
Sbjct: 969 ACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCNSQPCSQR 1028
Query: 971 VDENCKDKYYNCNVVVQARLCVYNYYKTACCASCTRVANR 1010
D+ CKD +C +VVQARLCVY YY CC SC V R
Sbjct: 1029 PDDQCKDSSPHCPLVVQARLCVYPYYTATCCRSCAHVLER 1068
Score = 33.9 bits (76), Expect = 0.80
Identities = 19/53 (35%), Positives = 25/53 (47%), Gaps = 6/53 (11%)
Query: 33 KVPQRMAAEGA-----PEDDGGGGAPGVWGAWGPWSACSRSCSGGVMEQTRPC 80
++ +R A GA PE G P W A G W++CSRSC G + C
Sbjct: 699 ELDERSCAAGARPPASPEPCHGTPCPPYWEA-GEWTSCSRSCGPGTQHRQLQC 750
>gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo
sapiens]
Length = 877
Score = 481 bits (1239), Expect = e-135
Identities = 302/849 (35%), Positives = 406/849 (47%), Gaps = 119/849 (14%)
Query: 49 GGGAPGVWGAWGPWSACSRSCSGGVMEQTRPCL-------------------PRSYRLRG 89
G G GVWG W W++CS+ C GV ++R C P + RG
Sbjct: 40 GQGPEGVWGPWVQWASCSQPCGVGVQRRSRTCQLPTVQLHPSLPLPPRPPRHPEALLPRG 99
Query: 90 -GQRP-----------------GAPARAFADHV-------VSAVRTS------------- 111
G RP G P R A H+ + A R S
Sbjct: 100 QGPRPQTSPETLPLYRTQSRGRGGPLRGPASHLGREETQEIRAARRSRLRDPIKPGMFGY 159
Query: 112 ------VPLHRSRDETPALAGTDASRQGPTVLRGSRHPQPQGLEVTGDRRSRTRGTIGPG 165
+PLHR+R + ++ S P P+ + + +T + P
Sbjct: 160 GRVPFALPLHRNRRHPRSPPRSELSLISSRGEEAIPSPTPRAEPFSANGSPQTE--LPPT 217
Query: 166 KYG-YGKAPYILPLQTDTAHTPQRLRRQKLSSRHSRSQGASSARHGYSSPAHQVPQHG-- 222
+ + +P PL +TA T R + RH AS SP H + + G
Sbjct: 218 ELSVHTPSPQAEPLSPETAQTEVAPRTRPAPLRHHPRAQASGTEP--PSPTHSLGEGGFF 275
Query: 223 -----PLYQSDSGPRSGLQAAEAP--IYQLPL---THDQGYPAASSLFHSP--ETSNNH- 269
P S G S A P +P QG H P E H
Sbjct: 276 RASPQPRRPSSQGWASPQVAGRRPDPFPSVPRGRGQQGQGPWGTGGTPHGPRLEPDPQHP 335
Query: 270 -------GVGTHGATQSFSQPARSTAIS-CIGAYRQYKLCNTNVCPESSRSIREVQCASY 321
G H A+ +S A S+ I C G Q + C+ CP R +QCA++
Sbjct: 336 GAWLPLLSNGPH-ASSLWSLFAPSSPIPRCSGESEQLRACSQAPCPPEQPDPRALQCAAF 394
Query: 322 NNKPFMGRFYEWEPFAEVKGNRKCELNCQAMGYRFYVRQAEKVIDGTPCDQNGTAICVSG 381
N++ FMG+ Y+WEPF EV+G+++CELNC+ G+RFYVR EKV DGT C ICV+G
Sbjct: 395 NSQEFMGQLYQWEPFTEVQGSQRCELNCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAG 454
Query: 382 QCKSIGCDDYLGSDKVVDKCGVCGGDNTGCQVVSGVFKHALTSLGYHRVVEIPEGATKIN 441
+C S GCD LGS + D CGVCGGD++ C++VSG LGY +++ IP GA ++
Sbjct: 455 RCLSPGCDGILGSGRRPDGCGVCGGDDSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQ 514
Query: 442 ITEMYKSNNYLALRSRSGRSIINGNWAIDRPGKYEGGGTMFTYKRPNEISSTAGESFLAE 501
I ++ S+NYLALR GRSIINGNWA+D PG Y GGT+F Y RP GES AE
Sbjct: 515 IAQLRPSSNYLALRGPGGRSIINGNWAVDPPGSYRAGGTVFRYNRPPR-EEGKGESLSAE 573
Query: 502 GPTNEILDVYMIHQQPNPGVHYEYVIMGTNAISPQVPPHRRPGEPFNGQMVTEGRSQEEG 561
GPT + +DVYMI Q+ NPGV Y+YVI I P EP Q+
Sbjct: 574 GPTTQPVDVYMIFQEENPGVFYQYVISSPPPILENPTP-----EPPVPQL---------- 618
Query: 562 EQKGRNEEKEDLRGEAPEMFTSESAQTFPVRHPDRFSPHRPDNLVPPAPQPPRRSRDHNW 621
+ E LR E P A+T P P PP P+ P S W
Sbjct: 619 -------QPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMP---APPHPRTPLGSPAAYW 668
Query: 622 KQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPCPAFWD 681
K++G + CS +CGKG PIF C+ R + EE E C + +P EPC+ PCP +W+
Sbjct: 669 KRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYWE 728
Query: 682 IGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKICSEWQI 741
GEW+ CS++CG G QHRQ+ CRQ + +V P RC HL +P T +CQL++C W++
Sbjct: 729 AGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWEV 788
Query: 742 RTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEEC-NMKLRPNDIENCDMGPCAKSWFLT 800
+ W+ CSV CG GQR+R V+CV N GD V ++EC + +P E CDMGPC +WF +
Sbjct: 789 GSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFHS 848
Query: 801 EWSERCSAE 809
+WS + S E
Sbjct: 849 DWSSKVSPE 857
Score = 106 bits (264), Expect = 1e-22
Identities = 67/188 (35%), Positives = 89/188 (47%), Gaps = 13/188 (6%)
Query: 742 RTDWTSCSVPCGVGQRTRDVKCVSN-IGDVVDDEECNMKLRPN-DIENCDMGPCAKSWFL 799
R ++CS CG G C+S G+ +D+ C RP E C PC W
Sbjct: 670 RVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYWEA 729
Query: 800 TEWSERCSAECGAGVRTRSVVCMTNHV---SSLPLEGCGN-NRPAEATPCDNGPCTGKVE 855
EW+ CS CG G + R + C SS+P E CG+ RP C C
Sbjct: 730 GEWTS-CSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCG---H 785
Query: 856 WFAGS-WSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPCGA 914
W GS WSQCS+ CG G + R+V CV N D EV + S +PPS+++C + PC
Sbjct: 786 WEVGSPWSQCSVRCGRGQRSRQVRCVGNNGD--EVSEQECASGPPQPPSREACDMGPCTT 843
Query: 915 KWFSTEWS 922
WF ++WS
Sbjct: 844 AWFHSDWS 851
Score = 100 bits (249), Expect = 7e-21
Identities = 57/168 (33%), Positives = 77/168 (45%), Gaps = 8/168 (4%)
Query: 806 CSAECGAGVRTRSVVCMTNHVSS-LPLEGC--GNNRPAEATPCDNGPCTGKVEWFAGSWS 862
CSA CG GV +C++ L C G PA PC PC W AG W+
Sbjct: 676 CSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPY--WEAGEWT 733
Query: 863 QCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPCGAKWFSTEWS 922
CS CG GTQ R++ C ++ + P C L +P QSC L+ CG + WS
Sbjct: 734 SCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWEVGSPWS 793
Query: 923 MCSKSCQGGFRVREVRCL---SDDMTLSNLCDPQLKPEERESCNPQDC 967
CS C G R R+VRC+ D+++ +P RE+C+ C
Sbjct: 794 QCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPC 841
Score = 60.8 bits (146), Expect = 6e-09
Identities = 34/118 (28%), Positives = 54/118 (45%), Gaps = 8/118 (6%)
Query: 856 WFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPP-SQQSCHLKPCGA 914
W S CS CG G + +C+ + ++ E LD C+ +PP S + CH PC
Sbjct: 668 WKRVGHSACSASCGKGVWRPIFLCISR--ESGEELDERSCAAGARPPASPEPCHGTPCPP 725
Query: 915 KWFSTEWSMCSKSCQGGFRVREVRCLSD-----DMTLSNLCDPQLKPEERESCNPQDC 967
W + EW+ CS+SC G + R+++C + C +P +SC + C
Sbjct: 726 YWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLC 783
Score = 33.9 bits (76), Expect = 0.80
Identities = 19/53 (35%), Positives = 25/53 (47%), Gaps = 6/53 (11%)
Query: 33 KVPQRMAAEGA-----PEDDGGGGAPGVWGAWGPWSACSRSCSGGVMEQTRPC 80
++ +R A GA PE G P W A G W++CSRSC G + C
Sbjct: 699 ELDERSCAAGARPPASPEPCHGTPCPPYWEA-GEWTSCSRSCGPGTQHRQLQC 750
>gi|124430557 a disintegrin-like and metalloprotease with
thrombospondin type 1 motifs 20 [Homo sapiens]
Length = 1910
Score = 320 bits (819), Expect = 6e-87
Identities = 227/741 (30%), Positives = 335/741 (45%), Gaps = 81/741 (10%)
Query: 266 SNNHGVGTHGATQSFSQPA-RSTAISCIGAYRQYKLCNTNVCPESSRSIREVQCASYNNK 324
S G G AT+ ++P R+ C+G +++ CNT+ CP+ ++ RE QC+ +N K
Sbjct: 569 SRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDSCPKGTQDFREKQCSDFNGK 628
Query: 325 PF----MGRFYEWEP-FAEVKGNRKCELNCQAMGYRFYVRQAEKVIDGTPCDQNGTAICV 379
+ W P ++ + +C+L CQ G ++ + V DGTPC ICV
Sbjct: 629 HLDISGIPSNVRWLPRYSGIGTKDRCKLYCQVAGTNYFYLLKDMVEDGTPCGTETHDICV 688
Query: 380 SGQCKSIGCDDYLGSDKVVDKCGVCGGDNTGCQVVSGVFKHALTSLGYHRVVEIPEGATK 439
GQC + GCD L S +DKCGVCGGDN+ C+ ++GVF + GY+ VV+IP GAT
Sbjct: 689 QGQCMAAGCDHVLNSSAKIDKCGVCGGDNSSCKTITGVFNS--SHYGYNVVVKIPAGATN 746
Query: 440 INITEMYKS----NNYLALRSRSGRSIINGNWAIDRPGK---YEGGGTMFTYKRPNEISS 492
++I + S ++YLAL G + NGN+ + K +G T+ Y N
Sbjct: 747 VDIRQYSYSGQPDDSYLALSDAEGNFLFNGNFLLSTSKKEINVQGTRTVIEYSGSNNAVE 806
Query: 493 TAGESFLAEGPTNEILDVYMIHQQPNPGVHYEYVIMGTNAISPQVPPHRRPGEPFNGQMV 552
+ E IL V + NP VHY + I P E +
Sbjct: 807 RINSTNRQE--KELILQVLCVGNLYNPDVHYSFNI---------------PLEERSDMFT 849
Query: 553 TEGRSQEEGEQKGRNEEKEDLRGEAPEMFTSESAQTFPVRHPDRFSPHRPDNLVPPAPQP 612
+ EG K +G T V D+ H P L Q
Sbjct: 850 WDPYGPWEGCTK-------MCQGLQRRNITCIHKSDHSV-VSDKECDHLP--LPSFVTQS 899
Query: 613 PRRSRDHNWKQLGTTECSTTCGKGSQYPIFRCVHRSTHE----EAPESYCDSSMKPTPEE 668
+ W +G +ECS+ CG+G + C+ S HE + + YC +KP P +
Sbjct: 900 CNTDCELRWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKP-PTQ 958
Query: 669 EPCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETT 728
E C+ W EWS+CS++CG G + R+ C + +R + CQ L + T
Sbjct: 959 ELCHGNCVFTRWHYSEWSQCSRSCGGGERSRESYCMNNFGHR---LADNECQELSR-VTR 1014
Query: 729 STCQLKICSEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENC 788
C C W ++W+ C V CG G + R V C N+ D + D CN +P + C
Sbjct: 1015 ENCNEFSCPSW-AASEWSECLVTCGKGTKQRQVWCQLNV-DHLSDGFCNSSTKPESLSPC 1072
Query: 789 DMGPCAKSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEG--CGN-NRPAEATPC 845
++ CA SW + W C+ CG G + R V C+ N ++S LE C +RP++ C
Sbjct: 1073 ELHTCA-SWQVGPWGP-CTTTCGHGYQMRDVKCV-NELASAVLEDTECHEASRPSDRQSC 1129
Query: 846 DNGPCT--GKVE--------------WFAGSWSQCSIECGSGTQQREVICVRKNADTFEV 889
PC+ K+E W GSW+ CS+ CG GTQ R V C R D +
Sbjct: 1130 VLTPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSC-RDALD--RI 1186
Query: 890 LDPSECSFLEKPPSQQSCHLKPCGAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTL-SN 948
D S C+ L +P C PCG +W + +WS CS SC G R+V C++ + N
Sbjct: 1187 ADESYCAHLPRPAEIWDC-FTPCG-EWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDEN 1244
Query: 949 LCDPQLKPEERESCNPQDCVP 969
CDP+++P + C+ C P
Sbjct: 1245 YCDPEVRPLMEQECSLAACPP 1265
Score = 186 bits (472), Expect = 1e-46
Identities = 132/448 (29%), Positives = 185/448 (41%), Gaps = 77/448 (17%)
Query: 611 QPPRRSRDHN------WKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKP 664
+PP + H W ++CS +CG G + C++ H A ++ C +
Sbjct: 954 KPPTQELCHGNCVFTRWHYSEWSQCSRSCGGGERSRESYCMNNFGHRLA-DNECQELSRV 1012
Query: 665 TPEEEPCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEK 724
T E CN F CP+ W EWSEC TCG G + RQV C+ + S C K
Sbjct: 1013 TREN--CNEFSCPS-WAASEWSECLVTCGKGTKQRQVWCQLNVDHLSDGF----CNSSTK 1065
Query: 725 PETTSTCQLKICSEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGD-VVDDEECNMKLRPN 783
PE+ S C+L C+ WQ+ W C+ CG G + RDVKCV+ + V++D EC+ RP+
Sbjct: 1066 PESLSPCELHTCASWQVGP-WGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPS 1124
Query: 784 DIENCDMGPCA------------------KSWFLTEWSERCSAECGAGVRTRSVVCMTNH 825
D ++C + PC+ W W+ CS CG G + R V C
Sbjct: 1125 DRQSCVLTPCSFISKLETALLPTVLIKKMAQWRHGSWTP-CSVSCGRGTQARYVSCRDAL 1183
Query: 826 VSSLPLEGCGN-NRPAEATPCDNGPCTGKVEWFAGSWSQCSIECGSGTQQREVICVRKNA 884
C + RPAE C PC EW AG WS CS CG G R+V+C+ +
Sbjct: 1184 DRIADESYCAHLPRPAEIWDCFT-PCG---EWQAGDWSPCSASCGHGKTTRQVLCMNYHQ 1239
Query: 885 DTFE-VLDPS-------ECSFLEKPPSQ-----------------------------QSC 907
E DP ECS PP+ Q
Sbjct: 1240 PIDENYCDPEVRPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVV 1299
Query: 908 HLKPCGAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERESCNPQDC 967
H G +W + W CS SC GG + R V C ++ ++ CD KP E + C P C
Sbjct: 1300 HPSVRGNQWRTGPWGSCSSSCSGGLQHRAVVCQDENGQSASYCDAASKPPELQQCGPGPC 1359
Query: 968 VPEVDENCKDKYYNCNVVVQARLCVYNY 995
N + C +++RL + +
Sbjct: 1360 PQWNYGNWGECSQTCGGGIKSRLVICQF 1387
Score = 167 bits (423), Expect = 5e-41
Identities = 112/394 (28%), Positives = 160/394 (40%), Gaps = 64/394 (16%)
Query: 621 WKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPCPAFW 680
W+ T CS +CG+G+Q C + A ESYC + P P E PC W
Sbjct: 1156 WRHGSWTPCSVSCGRGTQARYVSC-RDALDRIADESYC--AHLPRPAEIWDCFTPCGE-W 1211
Query: 681 DIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKIC---- 736
G+WS CS +CG G RQVLC N + C +P C L C
Sbjct: 1212 QAGDWSPCSASCGHGKTTRQVLCM----NYHQPIDENYCDPEVRPLMEQECSLAACPPAH 1267
Query: 737 --------------------------------------SEWQIRTDWTSCSVPCGVGQRT 758
++W+ W SCS C G +
Sbjct: 1268 SHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGP-WGSCSSSCSGGLQH 1326
Query: 759 RDVKCVSNIGDVVDDEECNMKLRPNDIENCDMGPCAKSWFLTEWSERCSAECGAGVRTRS 818
R V C G C+ +P +++ C GPC + W W E CS CG G+++R
Sbjct: 1327 RAVVCQDENGQSAS--YCDAASKPPELQQCGPGPCPQ-WNYGNWGE-CSQTCGGGIKSRL 1382
Query: 819 VVCMTNHVSSLPLEGCGN-NRPAEATPCDNGPCTGKVEWFAGSWSQCSIECGSGTQQREV 877
V+C + L C N+P C C V W W+ CS CG G + REV
Sbjct: 1383 VICQFPNGQILEDHNCEIVNKPPSVIQCHMHACPADVSWHQEPWTSCSASCGKGRKYREV 1442
Query: 878 ICVRKNADTFE-VLDPSECSFLEKPPSQQSCHLKPCGAKWFSTEWSMCSKSCQGGFRVRE 936
C+ D F+ L+ + CS ++KPP+ ++C C + W + W+ CS +C G + R+
Sbjct: 1443 FCI----DQFQRKLEDTNCSQVQKPPTHKACRSVRCPS-WKANSWNECSVTCGSGVQQRD 1497
Query: 937 VRCLSDDM--TLSNLCDPQLKPEERESCNPQDCV 968
V C + + +CD +P + C QDCV
Sbjct: 1498 VYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCV 1531
Score = 151 bits (382), Expect = 3e-36
Identities = 114/418 (27%), Positives = 173/418 (41%), Gaps = 79/418 (18%)
Query: 617 RDHNWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPC 676
R + W+ CS++C G Q+ R V SYCD++ KP PE + C PC
Sbjct: 1304 RGNQWRTGPWGSCSSSCSGGLQH---RAVVCQDENGQSASYCDAASKP-PELQQCGPGPC 1359
Query: 677 PAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKIC 736
P W+ G W ECS+TCG G++ R V+C+ + N + ++ + C+ + KP + C + C
Sbjct: 1360 PQ-WNYGNWGECSQTCGGGIKSRLVICQ--FPNGQI-LEDHNCEIVNKPPSVIQCHMHAC 1415
Query: 737 S---EWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCDMGPC 793
W + WTSCS CG G++ R+V C+ ++D C+ +P + C C
Sbjct: 1416 PADVSWH-QEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRC 1474
Query: 794 AKSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCG-NNRPAEATPCDNGPCTG 852
SW W+E CS CG+GV+ R V C V + E C + RP C + C
Sbjct: 1475 -PSWKANSWNE-CSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCVQ 1532
Query: 853 KVEWFAGSWSQCSIECG----------SGTQQREVICVRKNADTFEV------------- 889
G + CS C + Q R+V + N+ T +
Sbjct: 1533 HKGMERGRLN-CSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTISLTSKNCRNPPCNYI 1591
Query: 890 ---LDPSEC------SFLE-------------------KPPSQQSCHLKPCG-------- 913
D S+C S+ + +P Q C + P
Sbjct: 1592 VVTADSSQCANNCGFSYRQRITYCTEIPSTKKHKLHRLRPIVYQECPVVPSSQVYQCINS 1651
Query: 914 ----AKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERESCNPQDC 967
A W +WS CS +C G R+V+C++ S+LC LKP ++ C DC
Sbjct: 1652 CLHLATWKVGKWSKCSVTCGIGIMKRQVKCITKHGLSSDLCLNHLKPGAQKKCYANDC 1709
Score = 43.1 bits (100), Expect = 0.001
Identities = 15/27 (55%), Positives = 19/27 (70%)
Query: 54 GVWGAWGPWSACSRSCSGGVMEQTRPC 80
G WG W P+S+CSR+C GG+ TR C
Sbjct: 557 GEWGPWEPYSSCSRTCGGGIESATRRC 583
Score = 32.3 bits (72), Expect = 2.3
Identities = 11/21 (52%), Positives = 14/21 (66%)
Query: 60 GPWSACSRSCSGGVMEQTRPC 80
GPW +CS SCSGG+ + C
Sbjct: 1311 GPWGSCSSSCSGGLQHRAVVC 1331
Score = 31.2 bits (69), Expect = 5.2
Identities = 27/114 (23%), Positives = 43/114 (37%), Gaps = 28/114 (24%)
Query: 867 ECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPCGAKWFSTE-WSMCS 925
+CG G R +CV K +T +P +W E +S CS
Sbjct: 533 DCGPGMHCRHGLCVNKETET-----------------------RPVNGEWGPWEPYSSCS 569
Query: 926 KSCQGGFRVREVRC-LSDDMTLSNLCDPQLKPEERESCNPQDCVPEVDENCKDK 978
++C GG RC + N C + + SCN C P+ ++ ++K
Sbjct: 570 RTCGGGIESATRRCNRPEPRNGGNYCVG--RRMKFRSCNTDSC-PKGTQDFREK 620
>gi|110735441 ADAM metallopeptidase with thrombospondin type 1 motif,
16 preproprotein [Homo sapiens]
Length = 1224
Score = 307 bits (786), Expect = 4e-83
Identities = 195/591 (32%), Positives = 287/591 (48%), Gaps = 66/591 (11%)
Query: 291 CIGAYRQYKLCNTNVCPESSRSIREVQCASYNNKPFMGRFYEWEPFAEVKGNRKCELNCQ 350
C G+ R KLCN+ CP S R QCA +N++ F GR Y+W+P+ +V+ C+L C
Sbjct: 625 CEGSTRTLKLCNSQKCPRDSVDFRAAQCAEHNSRRFRGRHYKWKPYTQVEDQDLCKLYCI 684
Query: 351 AMGYRFYVRQAEKVIDGTPCDQNGTAICVSGQCKSIGCDDYLGSDKVVDKCGVCGGDNTG 410
A G+ F+ + KV DGTPC ++ +C+ G C+ +GCD+ LGSD V D CGVC G+N+
Sbjct: 685 AEGFDFFFSLSNKVKDGTPCSEDSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGNNSA 744
Query: 411 CQVVSGVF-KHALTSLGYHRVVEIPEGATKINITEMYKSNNYLALRSRSGRSIINGNWAI 469
C + G++ KH T+ YH +V IP GA I I EM S +Y+++R+ R +NG+W +
Sbjct: 745 CTIHRGLYTKHHHTNQYYH-MVTIPSGARSIRIYEMNVSTSYISVRNALRRYYLNGHWTV 803
Query: 470 DRPGKYEGGGTMFTYKRPNEISSTAGESFLAEGPTNEILDVYMIHQQPNPGVHYEYVI-- 527
D PG+Y+ GT F Y+R S E+ +A GPTNE L V ++ Q NPGV +EY +
Sbjct: 804 DWPGRYKFSGTTFDYRR----SYNEPENLIATGPTNETLIVELLFQGRNPGVAWEYSMPR 859
Query: 528 MGTNAISPQVPPHRRPGEPFNGQMVTEGRSQEEGEQKGRNEEKEDLRGEAPEMFTSESAQ 587
+GT P P + + G G+ R DL+ + F + +
Sbjct: 860 LGTEKQPPAQPSYTWAIVRSECSVSCGG-----GQMTVREGCYRDLKFQVNMSFCNPKTR 914
Query: 588 TFPVRHPDRFSPHRPDNLVPPAPQPPRRSRDHNWKQLGTTECSTTCGKGSQYPIFRCVHR 647
P + S P +W + CS TCG G+Q +C R
Sbjct: 915 PVTGLVPCKVSACPP-----------------SWSVGNWSACSRTCGGGAQSRPVQCTRR 957
Query: 648 STH--EEAPESYCDSSMKPTP-EEEPCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCR 704
+ E P S C +P P + CN CP W G W+ECS TCG G + R V C+
Sbjct: 958 VHYDSEPVPASLCP---QPAPSSRQACNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACK 1014
Query: 705 QVYANRSLTVQPYR-CQHLEKPETTSTCQLKICS-----EWQIRTDWTSCSVPCGVGQRT 758
+ + P C KP C L+ C +W + + W+ CSV C G +
Sbjct: 1015 STNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLV-SAWSQCSVTCERGTQK 1073
Query: 759 RDVKC----VSNIGDVVDDEECNMKLRPN-DIEN-CDMGPCAK------------SWFLT 800
R +KC VS + ++C+ +P+ ++E C PC + SWF +
Sbjct: 1074 RFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRHPPFAAAGPSRGSWFAS 1133
Query: 801 EWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGC-GNNRPAEATPCDNGPC 850
WS+ C+A CG GV+TRSV C+ P GC + +P+ + C+ C
Sbjct: 1134 PWSQ-CTASCGGGVQTRSVQCL---AGGRPASGCLLHQKPSASLACNTHFC 1180
Score = 153 bits (386), Expect = 9e-37
Identities = 105/351 (29%), Positives = 158/351 (45%), Gaps = 38/351 (10%)
Query: 686 SECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTST-CQLKICS-EWQIRT 743
SECS +CG G + C Y + V C +P T C++ C W +
Sbjct: 879 SECSVSCGGGQMTVREGC---YRDLKFQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVG- 934
Query: 744 DWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKL----RPNDIENCDMGPCAKSWFL 799
+W++CS CG G ++R V+C + D E L P+ + C+ C +W
Sbjct: 935 NWSACSRTCGGGAQSRPVQCTRRVH--YDSEPVPASLCPQPAPSSRQACNSQSCPPAWSA 992
Query: 800 TEWSERCSAECGAGVRTRSVVCMTNHVSS----LPLEGCGNN-RPAEATPCDNGPC--TG 852
W+E CS CG G R R+V C + + S+ LP C + +P C C
Sbjct: 993 GPWAE-CSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPK 1051
Query: 853 KVEWFAGSWSQCSIECGSGTQQREVICVRKNAD-TFEVLDPSECSFLEKPPSQ--QSCHL 909
K++W +WSQCS+ C GTQ+R + C K + L +CS L KP + ++C
Sbjct: 1052 KLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAP 1111
Query: 910 KPCG------------AKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPE 957
PC WF++ WS C+ SC GG + R V+CL+ S C KP
Sbjct: 1112 LPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRPASG-CLLHQKPS 1170
Query: 958 ERESCNPQDC--VPEVDENCKDKYYNCNVVVQARLCVYNYYKTACCASCTR 1006
+CN C + D CKD ++ C +V Q +C + +Y CC +C++
Sbjct: 1171 ASLACNTHFCPIAEKKDAFCKDYFHWCYLVPQHGMCSHKFYGKQCCKTCSK 1221
Score = 140 bits (354), Expect = 5e-33
Identities = 96/329 (29%), Positives = 130/329 (39%), Gaps = 40/329 (12%)
Query: 611 QPPRRSRDHNWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEP 670
QPP + + W + +ECS +CG G Q + +R + S+C+ +P P
Sbjct: 865 QPPAQP-SYTWA-IVRSECSVSCG-GGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVP 921
Query: 671 CNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTST 730
C + CP W +G WS CS+TCG G Q R V C + S V C P +
Sbjct: 922 CKVSACPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQ-PAPSSRQA 980
Query: 731 CQLKICSEWQIRTDWTSCSVPCGVGQRTRDVKCVSN----IGDVVDDEECNMKLRPNDIE 786
C + C W CS CG G R R V C S ++ D C + +P E
Sbjct: 981 CNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHE 1040
Query: 787 NCDMGPCAK----SWFLTEWSERCSAECGAGVRTRSVVCMTNHVSS------------LP 830
C + C K W ++ WS+ CS C G + R + C +VS LP
Sbjct: 1041 ACLLQRCHKPKKLQWLVSAWSQ-CSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLP 1099
Query: 831 LEGCGNNRPAEATPCDN-------GPCTGKVEWFAGSWSQCSIECGSGTQQREVICVRKN 883
R PC GP G WFA WSQC+ CG G Q R V C+
Sbjct: 1100 KPSLELERACAPLPCPRHPPFAAAGPSRG--SWFASPWSQCTASCGGGVQTRSVQCLAGG 1157
Query: 884 ADTFEVLDPSECSFLEKPPSQQSCHLKPC 912
S C +KP + +C+ C
Sbjct: 1158 RPA------SGCLLHQKPSASLACNTHFC 1180
Score = 42.4 bits (98), Expect = 0.002
Identities = 16/35 (45%), Positives = 20/35 (57%)
Query: 46 DDGGGGAPGVWGAWGPWSACSRSCSGGVMEQTRPC 80
D+G G W W WS CSR+C GGV ++R C
Sbjct: 579 DEGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLC 613
Score = 37.7 bits (86), Expect = 0.055
Identities = 19/57 (33%), Positives = 27/57 (47%), Gaps = 1/57 (1%)
Query: 25 PQPSTQHRKVPQRMAAEGAPEDDGGGGAPGVWGAWGPWSACSRSCSGGVMEQTRPCL 81
P+PS + + + P G + G W A PWS C+ SC GGV ++ CL
Sbjct: 1099 PKPSLELERACAPLPCPRHPPFAAAGPSRGSWFA-SPWSQCTASCGGGVQTRSVQCL 1154
Score = 35.4 bits (80), Expect = 0.28
Identities = 15/30 (50%), Positives = 17/30 (56%), Gaps = 1/30 (3%)
Query: 675 PCPAFW-DIGEWSECSKTCGLGMQHRQVLC 703
P W D WS CS+TCG G+ HR LC
Sbjct: 584 PTHGHWSDWSSWSPCSRTCGGGVSHRSRLC 613
Score = 32.3 bits (72), Expect = 2.3
Identities = 14/31 (45%), Positives = 16/31 (51%), Gaps = 1/31 (3%)
Query: 53 PGVWGAWGPWSACSRSCSGGVMEQTRPCLPR 83
P W G WSACSR+C GG + C R
Sbjct: 928 PPSWSV-GNWSACSRTCGGGAQSRPVQCTRR 957
Score = 32.3 bits (72), Expect = 2.3
Identities = 26/97 (26%), Positives = 36/97 (37%), Gaps = 25/97 (25%)
Query: 23 VCPQPSTQHRKVPQRMAAEGAPEDDGGGGAPGVWGAWGPWSACSRSCSGGVMEQTRPCLP 82
+CPQP+ R+ + P W A GPW+ CS +C G ++ C
Sbjct: 969 LCPQPAPSSRQACNSQSC------------PPAWSA-GPWAECSHTCGKGWRKRAVAC-- 1013
Query: 83 RSYRLRGGQRPGAPARAFADHVVSAVRTSVPLHRSRD 119
P A A+ D AV TS P R +
Sbjct: 1014 ------KSTNPSARAQLLPD----AVCTSEPKPRMHE 1040
Score = 31.2 bits (69), Expect = 5.2
Identities = 19/64 (29%), Positives = 24/64 (37%), Gaps = 5/64 (7%)
Query: 821 CMTNHVSSLPLEGCGNNRPAEATPC----DNGPCTGKVEWFA-GSWSQCSIECGSGTQQR 875
C T + + CG++ C D GP W SWS CS CG G R
Sbjct: 550 CETKFMPAAEGTICGHDMWCRGGQCVKYGDEGPKPTHGHWSDWSSWSPCSRTCGGGVSHR 609
Query: 876 EVIC 879
+C
Sbjct: 610 SRLC 613
>gi|33624896 ADAM metallopeptidase with thrombospondin type 1 motif, 9
preproprotein [Homo sapiens]
Length = 1935
Score = 305 bits (780), Expect = 2e-82
Identities = 238/830 (28%), Positives = 333/830 (40%), Gaps = 176/830 (21%)
Query: 291 CIGAYRQYKLCNTNVCPESSRSIREVQCASYNNKPF----MGRFYEWEP-FAEVKGNRKC 345
C+G ++K CNT C + R R+ QCA ++ K F + W P ++ + +C
Sbjct: 627 CVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFDGKHFNINGLLPNVRWVPKYSGILMKDRC 686
Query: 346 ELNCQAMGYRFYVRQAEKVIDGTPCDQNGTAICVSGQCKSIGCDDYLGSDKVVDKCGVCG 405
+L C+ G Y + ++VIDGTPC Q+ ICV G C+ GCD L S DKCGVCG
Sbjct: 687 KLFCRVAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQAGCDHVLNSKARRDKCGVCG 746
Query: 406 GDNTGCQVVSGVFKHALTSLGYHRVVEIPEGATKINITEMYKS-----NNYLALRSRSGR 460
GDN+ C+ V+G F GY+ VV IP GAT I++ + S +NYLAL S G
Sbjct: 747 GDNSSCKTVAGTFN--TVHYGYNTVVRIPAGATNIDVRQHSFSGETDDDNYLALSSSKGE 804
Query: 461 SIINGNWAIDRPGK-YEGGGTMFTYKRPNEISSTAGESFLAEGPTNE--ILDVYMIHQQP 517
++NGN+ + + G + Y S TA E + + +L V + +
Sbjct: 805 FLLNGNFVVTMAKREIRIGNAVVEYSG----SETAVERINSTDRIEQELLLQVLSVGKLY 860
Query: 518 NPGVHYEYVIMGTNAISPQVPPHRRPGEPF-NGQMVTEGRSQE-EGEQKGRNEEKEDLRG 575
NP V Y + +P +P + + N + S+ +GE+K +
Sbjct: 861 NPDVRYSF----------NIPIEDKPQQFYWNSHGPWQACSKPCQGERKRKL-------- 902
Query: 576 EAPEMFTSESAQTFPVRHPDRFSPHRPDNLVPPA--PQPPRRSRDHNWKQLGTTECSTTC 633
+ T ES Q S R D L P +P D W +ECS C
Sbjct: 903 ----VCTRESDQL-------TVSDQRCDRLPQPGHITEPCGTDCDLRWHVASRSECSAQC 951
Query: 634 GKGSQYPIFRCVHRS----THEEAPESYCDSSMKPTPEEE---PCNI------------- 673
G G + C S E+ + +C S KP+ E+ CN
Sbjct: 952 GLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSNREKCSGECNTGGWRYSAWTECSK 1011
Query: 674 ---------------------------------------FPCPAFWDIGEWSECSKTCGL 694
FPCP W G+WSEC TCG
Sbjct: 1012 SCDGGTQRRRAICVNTRNDVLDDSKCTHQEKVTIQRCSEFPCPQ-WKSGDWSECLVTCGK 1070
Query: 695 GMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKICSEWQIRTDWTSCSVPCGV 754
G +HRQV C Q +R + C KP + TCQ C+ WQ W CSV CG
Sbjct: 1071 GHKHRQVWC-QFGEDR---LNDRMCDPETKPTSMQTCQQPECASWQ-AGPWGQCSVTCGQ 1125
Query: 755 GQRTRDVKC-VSNIGDVVDDEECNMKLRPNDIENCDMGPC-----------------AKS 796
G + R VKC + VVDD +CN RP D ++C++ C
Sbjct: 1126 GYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPPPAAPETRRSTYSAPRTQ 1185
Query: 797 WFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCGN-NRPAEATPCDNGPCTGKVE 855
W W+ CSA CG G R R V C + S C RP C PC +
Sbjct: 1186 WRFGSWTP-CSATCGKGTRMRYVSCRDENGSVADESACATLPRPVAKEECSVTPCG---Q 1241
Query: 856 WFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPC--- 912
W A WS CS+ CG G R+V+CV + V+D SEC P + Q C + PC
Sbjct: 1242 WKALDWSSCSVTCGQGRATRQVMCVNYSD---HVIDRSECDQDYIPETDQDCSMSPCPQR 1298
Query: 913 ------------------------------GAKWFSTEWSMCSKSCQGGFRVREVRCLSD 942
G +W + W CS +C GG + R V C +
Sbjct: 1299 TPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQDE 1358
Query: 943 DMTLSNLCDPQLKPEERESCNPQDCVPEVDENCKDKYYNCNVVVQARLCV 992
+ +N C ++KP+E+ +C C N + C ++ RL V
Sbjct: 1359 NGYTANDCVERIKPDEQRACESGPCPQWAYGNWGECTKLCGGGIRTRLVV 1408
Score = 208 bits (529), Expect = 2e-53
Identities = 127/368 (34%), Positives = 174/368 (47%), Gaps = 23/368 (6%)
Query: 621 WKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPCP--A 678
W EC+ CG G + + C RS E P+ C+ KP P+ E CN CP A
Sbjct: 1386 WAYGNWGECTKLCGGGIRTRLVVC-QRSNGERFPDLSCEILDKP-PDREQCNTHACPHDA 1443
Query: 679 FWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKICSE 738
W G WS CS +CG G + R V C A ++ C+HL KP C+ C +
Sbjct: 1444 AWSTGPWSSCSVSCGRGHKQRNVYCM---AKDGSHLESDYCKHLAKPHGHRKCRGGRCPK 1500
Query: 739 WQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCDMGPCAK-SW 797
W+ W+ CSV CG G + R V C + + ECN RP +C C +W
Sbjct: 1501 WKAGA-WSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCPLYTW 1559
Query: 798 FLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCG-NNRPAEATPCDNGPCTGKVEW 856
EW E C+ CG G R R VVC+ ++ + + C + RP + C PC + W
Sbjct: 1560 RAEEWQE-CTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPC--EYVW 1616
Query: 857 FAGSWSQCSIECGSGTQQREVICVR----KNADTFEVLDPSECSFLEKPPSQQSCHLKPC 912
G WS+CS+ CG G +QR V C K + C + PPS C+L+ C
Sbjct: 1617 ITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQ-PPSVHPCYLRDC 1675
Query: 913 --GAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERESC-NPQDCVP 969
A W W CS SC G R V+CL+++ S+LC LKPEER++C N +C
Sbjct: 1676 PVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTCRNVYNC-- 1733
Query: 970 EVDENCKD 977
E+ +NCK+
Sbjct: 1734 ELPQNCKE 1741
Score = 188 bits (477), Expect = 3e-47
Identities = 118/416 (28%), Positives = 173/416 (41%), Gaps = 69/416 (16%)
Query: 607 PPAPQPPRRSRDHNWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTP 666
P + Q ++ +W+ +CS TCG+G Q +C+ + ++ C+++ +PT
Sbjct: 1097 PTSMQTCQQPECASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTD 1156
Query: 667 EEEPCNIFPC---PAF--------------WDIGEWSECSKTCGLGMQHRQVLCRQVYAN 709
++ C + C PA W G W+ CS TCG G + R V CR
Sbjct: 1157 TQD-CELPSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRD---E 1212
Query: 710 RSLTVQPYRCQHLEKPETTSTCQLKICSEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGD 769
C L +P C + C +W+ DW+SCSV CG G+ TR V CV+
Sbjct: 1213 NGSVADESACATLPRPVAKEECSVTPCGQWKA-LDWSSCSVTCGQGRATRQVMCVNYSDH 1271
Query: 770 VVDDEECNMKLRPNDIENCDMGPCAK---------------------------------S 796
V+D EC+ P ++C M PC +
Sbjct: 1272 VIDRSECDQDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQ 1331
Query: 797 WFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNN-RPAEATPCDNGPCTGKVE 855
W W CS+ C G + R VVC + C +P E C++GPC +
Sbjct: 1332 WRTGPWGA-CSSTCAGGSQRRVVVCQDEN--GYTANDCVERIKPDEQRACESGPCP---Q 1385
Query: 856 WFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSC--HLKPCG 913
W G+W +C+ CG G + R V+C R N + F L C L+KPP ++ C H P
Sbjct: 1386 WAYGNWGECTKLCGGGIRTRLVVCQRSNGERFPDL---SCEILDKPPDREQCNTHACPHD 1442
Query: 914 AKWFSTEWSMCSKSCQGGFRVREVRCLSDDMT--LSNLCDPQLKPEERESCNPQDC 967
A W + WS CS SC G + R V C++ D + S+ C KP C C
Sbjct: 1443 AAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRC 1498
Score = 150 bits (379), Expect = 6e-36
Identities = 101/324 (31%), Positives = 139/324 (42%), Gaps = 32/324 (9%)
Query: 602 PDNLVPPAPQPPRRSR--------DHNWKQLGTTECSTTCGKGSQYPIFRCVHRS-THEE 652
PD +PP R + D W + CS +CG+G + C+ + +H E
Sbjct: 1418 PDLSCEILDKPPDREQCNTHACPHDAAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLE 1477
Query: 653 APESYCDSSMKPTPEEEPCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSL 712
+ YC KP + C CP W G WS+CS +CG G+Q R V C Q+ ++
Sbjct: 1478 S--DYCKHLAKPHGHRK-CRGGRCPK-WKAGAWSQCSVSCGRGVQQRHVGC-QIGTHK-- 1530
Query: 713 TVQPYRCQHLEKPETTSTCQLKICSEWQIRTD-WTSCSVPCGVGQRTRDVKCVSNIGDVV 771
+ C +PE+ CQ C + R + W C+ CG G R R V CV + + V
Sbjct: 1531 IARETECNPYTRPESERDCQGPRCPLYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEV 1590
Query: 772 DDEECNMKLRPNDIENCDMGPCAKSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPL 831
C++ RP D E+C + PC W EWSE CS CG G + R V C +
Sbjct: 1591 HGARCDVSKRPVDRESCSLQPCEYVWITGEWSE-CSVTCGKGYKQRLVSCSEIYTGKENY 1649
Query: 832 E-------GCGNNRPAEATPCDNGPCTGKVEWFAGSWSQCSIECGSGTQQREVICVRKNA 884
E C +P PC C W G+W CS+ CG G QR V C+ N
Sbjct: 1650 EYSYQTTINCPGTQPPSVHPCYLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCL-TNE 1708
Query: 885 DTFEVLDPSE-CSFLEKPPSQQSC 907
D PS C KP +++C
Sbjct: 1709 D-----QPSHLCHTDLKPEERKTC 1727
Score = 40.4 bits (93), Expect = 0.009
Identities = 13/27 (48%), Positives = 17/27 (62%)
Query: 54 GVWGAWGPWSACSRSCSGGVMEQTRPC 80
G WG+W P+ CSR+C GG+ R C
Sbjct: 589 GSWGSWSPFGTCSRTCGGGIKTAIREC 615
Score = 30.4 bits (67), Expect = 8.9
Identities = 9/16 (56%), Positives = 11/16 (68%)
Query: 56 WGAWGPWSACSRSCSG 71
W + GPW ACS+ C G
Sbjct: 881 WNSHGPWQACSKPCQG 896
>gi|40806187 ADAM metallopeptidase with thrombospondin type 1 motif,
18 preproprotein [Homo sapiens]
Length = 1221
Score = 303 bits (777), Expect = 4e-82
Identities = 187/555 (33%), Positives = 279/555 (50%), Gaps = 54/555 (9%)
Query: 291 CIGAYRQYKLCNTNVCPESSRSIREVQCASYNNKPFMGRFYEWEPFAEVKGNRKCELNCQ 350
C G+ R Y+LCN N C E+S R QCA YN+KPF G FY+W+P+ +V+ +C+L C+
Sbjct: 628 CPGSSRIYQLCNINPCNENSLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCK 687
Query: 351 AMGYRFYVRQAEKVIDGTPCDQNGTAICVSGQCKSIGCDDYLGSDKVVDKCGVCGGDNTG 410
A + F+ + KV DGTPC N +C+ G C+ +GCD LGS V D CGVC GDN+
Sbjct: 688 AENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNST 747
Query: 411 CQVVSGVFKHALTSLGYHRVVEIPEGATKINITEMYKSNNYLALRSRSGRSIINGNWAID 470
C+ G++ + + Y+ VV IP GA I I E+ S++YLA+RS S + + G W+ID
Sbjct: 748 CKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSID 807
Query: 471 RPGKYEGGGTMFTYKRPNEISSTAGESFLAEGPTNEILDVYMIHQQPNPGVHYEYVIMGT 530
PG++ GT F Y+R S E A GPTNE L ++ Q NPG+ ++Y +
Sbjct: 808 WPGEFPFAGTTFEYQR----SFNRPERLYAPGPTNETLVFEILMQGKNPGIAWKYAL--P 861
Query: 531 NAISPQVPPHRRPGEPFNGQMVTEGRSQEEGEQKGRNEEKEDLRGEAPEMFTSE-SAQTF 589
++ P +RP ++ + + N + LR + ++ +S SA+T
Sbjct: 862 KVMNGTPPATKRPAYTWS---IVQSECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTK 918
Query: 590 PVRHPDRFSPHRPDNLVPPAPQPPRRSRDHNWKQLGTTECSTTCGKGSQYPIFRCVHR-- 647
PV P + A P W + CS C G Q +CV +
Sbjct: 919 PVTEPK----------ICNAFSCPAYWMPGEW-----STCSKACAGGQQSRKIQCVQKKP 963
Query: 648 -STHEEAPESYCDSSMKPTPEEEPCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQV 706
E S C S PT + + CN CP W +G WS+CSKTCG G++ R++LC+
Sbjct: 964 FQKEEAVLHSLCPVS-TPT-QVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCK-- 1019
Query: 707 YANRSLTVQPYRCQHLEKPETTSTCQLKICS-----EWQIRTDWTSCSVPCGVGQRTRDV 761
+ + T+ +C L +PE C L C +W + + W+ CS CG+G R R++
Sbjct: 1020 -GSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQW-VASSWSECSATCGLGVRKREM 1077
Query: 762 KCVSN--IGDVV--DDEECNMKLRPN-DI-ENCDMGPC--------AKSWFLTEWSERCS 807
KC G ++ + C +PN D+ E C+ C W+ W ++C+
Sbjct: 1078 KCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAGWYSLPW-QQCT 1136
Query: 808 AECGAGVRTRSVVCM 822
CG GV+TRSV C+
Sbjct: 1137 VTCGGGVQTRSVHCV 1151
Score = 176 bits (446), Expect = 1e-43
Identities = 119/421 (28%), Positives = 170/421 (40%), Gaps = 84/421 (19%)
Query: 604 NLVPPAPQPPRRSRDHNWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMK 663
N PPA + P + W + +ECS +CG G C+ R + + S+C + K
Sbjct: 865 NGTPPATKRPA----YTWS-IVQSECSVSCGGGYINVKAICL-RDQNTQVNSSFCSAKTK 918
Query: 664 PTPEEEPCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLE 723
P E + CN F CPA+W GEWS CSK C G Q R++ C Q + + +
Sbjct: 919 PVTEPKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVS 978
Query: 724 KPETTSTCQLKICSEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPN 783
P C C W+ CS CG G R R++ C + + + + +C RP
Sbjct: 979 TPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPE 1038
Query: 784 DIENCDMGPCAKS----WFLTEWSERCSAECGAGVRTRSVVC----MTNHVSSLPLEGCG 835
E C +G C K+ W + WSE CSA CG GVR R + C + + P C
Sbjct: 1039 LQEGCVLGRCPKNSRLQWVASSWSE-CSATCGLGVRKREMKCSEKGFQGKLITFPERRCR 1097
Query: 836 N----NRPAEATPCDNGPCTGK------VEWFAGSWSQCSIECGSGTQQREVICVRKNAD 885
N N E T C+ C W++ W QC++ CG G Q R V CV++
Sbjct: 1098 NIKKPNLDLEET-CNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRP 1156
Query: 886 TFEVLDPSECSFLEKPPSQQSCHLKPCGAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMT 945
+ S C +KPP ++C+ C A
Sbjct: 1157 S------SSCLLHQKPPVLRACNTNFCPA------------------------------- 1179
Query: 946 LSNLCDPQLKPEERESCNPQDCVPEVDENCKDKYYNCNVVVQARLCVYNYYKTACCASCT 1005
PE+RE D +C D + C++V Q +C + +Y CC SCT
Sbjct: 1180 ----------PEKRE-----------DPSCVDFFNWCHLVPQHGVCNHKFYGKQCCKSCT 1218
Query: 1006 R 1006
R
Sbjct: 1219 R 1219
Score = 42.7 bits (99), Expect = 0.002
Identities = 16/27 (59%), Positives = 17/27 (62%)
Query: 54 GVWGAWGPWSACSRSCSGGVMEQTRPC 80
G W AW WS CSR+C GGV Q R C
Sbjct: 590 GQWSAWSKWSECSRTCGGGVKFQERHC 616
Score = 31.6 bits (70), Expect = 4.0
Identities = 17/64 (26%), Positives = 28/64 (43%), Gaps = 18/64 (28%)
Query: 658 CDSSMKPTPEEEPCNIF------PCPAFWDIG------------EWSECSKTCGLGMQHR 699
C++ P E C + C F ++G +WSECS+TCG G++ +
Sbjct: 553 CETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPRPIHGQWSAWSKWSECSRTCGGGVKFQ 612
Query: 700 QVLC 703
+ C
Sbjct: 613 ERHC 616
Score = 30.8 bits (68), Expect = 6.8
Identities = 22/87 (25%), Positives = 31/87 (35%), Gaps = 7/87 (8%)
Query: 848 GPCTGKVEWFAGS-WSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQS 906
GP +W A S WS+CS CG G + +E C + P Q
Sbjct: 584 GPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRI------YQL 637
Query: 907 CHLKPCGAKWFSTEWSMCSKSCQGGFR 933
C++ PC C++ FR
Sbjct: 638 CNINPCNENSLDFRAQQCAEYNSKPFR 664
Score = 30.4 bits (67), Expect = 8.9
Identities = 11/31 (35%), Positives = 20/31 (64%), Gaps = 1/31 (3%)
Query: 910 KPCGAKWFS-TEWSMCSKSCQGGFRVREVRC 939
+P +W + ++WS CS++C GG + +E C
Sbjct: 586 RPIHGQWSAWSKWSECSRTCGGGVKFQERHC 616
>gi|64276808 ADAM metallopeptidase with thrombospondin type 1 motif, 6
preproprotein [Homo sapiens]
Length = 1117
Score = 302 bits (774), Expect = 9e-82
Identities = 184/537 (34%), Positives = 256/537 (47%), Gaps = 47/537 (8%)
Query: 264 ETSNNHGVGTHGATQSFSQPARSTAIS-CIGAYRQYKLCNTNVCPESSRSIREVQCASYN 322
E S G G + + PA S C+G ++Y+ CNT+ CP SR RE QCA ++
Sbjct: 569 ECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSRDFREKQCADFD 628
Query: 323 NKPFMGRFYEWEPFAEVKGNRKCELNCQAMGYRFYVRQAEKVIDGTPCDQNGTAICVSGQ 382
N PF G++Y W+P+ G + C LNC A GY FY +A VIDGT C+ + IC++G+
Sbjct: 629 NMPFRGKYYNWKPYTG-GGVKPCALNCLAEGYNFYTERAPAVIDGTQCNADSLDICINGE 687
Query: 383 CKSIGCDDYLGSDKVVDKCGVCGGDNTGCQVVSGVFKHALTSLGYHRVVEIPEGATKINI 442
CK +GCD+ LGSD D+C VCGGD + C + G F +L GY VV+IP G+ I +
Sbjct: 688 CKHVGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEV 747
Query: 443 TEMYKSNNYLALRSRSGRSIINGNWAIDRPGKYEGGGTMFTYKRPNEISSTAGESFLAEG 502
E+ S NY+AL+S ING W ID P K++ GT F YKRP + ES A G
Sbjct: 748 REVAMSKNYIALKSEGDDYYINGAWTIDWPRKFDVAGTAFHYKRPTD----EPESLEALG 803
Query: 503 PTNEILDVYMIHQQPNPGVHYEYVIMGTNAISPQVPPHRRPGEPFNGQMVTEGRSQEEGE 562
PT+E L V ++ Q+ N G+ Y++ + T S G +N Q +E + G
Sbjct: 804 PTSENLIVMVLLQEQNLGIRYKFNVPITRTGSGD----NEVGFTWNHQPWSECSATCAGG 859
Query: 563 QKGRNEEKEDLRGEAPEMFTSESAQTFPVRHPDRFSPHRPDNLVPPAPQPPRRSRDHN-- 620
+ + + L + +N P +PP R N
Sbjct: 860 VQRQEVVCKRLDDNSIVQ----------------------NNYCDPDSKPPENQRACNTE 897
Query: 621 -----WKQLGTTECSTTCGKGSQYPIFRCVHR-STHEEAPESYCDSSMKPTPEEEPCNIF 674
W ECS TC G + C+ + EE Y E+EPCN
Sbjct: 898 PCPPEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQ 957
Query: 675 PCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLK 734
CP W +WSEC+ CG G +HR VLC+ ++ S T +C KP C L
Sbjct: 958 SCPPQWVALDWSECTPKCGPGFKHRIVLCKS--SDLSKTFPAAQCPEESKPPVRIRCSLG 1015
Query: 735 IC--SEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCD 789
C W + DW CS CG+GQ+ R V+C+S G D C +RP ++ C+
Sbjct: 1016 RCPPPRW-VTGDWGQCSAQCGLGQQMRTVQCLSYTGQASSD--CLETVRPPSMQQCE 1069
Score = 153 bits (387), Expect = 7e-37
Identities = 85/271 (31%), Positives = 137/271 (50%), Gaps = 16/271 (5%)
Query: 745 WTSCSVPCGVGQRTRDVKCVS-NIGDVVDDEECNMKLRPNDIEN-CDMGPCAKSWFLTEW 802
W+ CS C G + ++V C + +V + C+ +P + + C+ PC WF+ +W
Sbjct: 849 WSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEWFIGDW 908
Query: 803 SERCSAECGAGVRTRSVVCMT----NHVSSLPLEGCGNNRPAEATPCDNGPCTGKVEWFA 858
E CS C G+RTR+V+C+ + +L GC +RP E PC+N C +W A
Sbjct: 909 LE-CSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPP--QWVA 965
Query: 859 GSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPCGA-KWF 917
WS+C+ +CG G + R V+C K++D + ++C KPP + C L C +W
Sbjct: 966 LDWSECTPKCGPGFKHRIVLC--KSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWV 1023
Query: 918 STEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERESCNPQ-DCVP-EVDENC 975
+ +W CS C G ++R V+CLS S+ C ++P + C + D P E C
Sbjct: 1024 TGDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCESKCDSTPISNTEEC 1083
Query: 976 KD--KYYNCNVVVQARLCVYNYYKTACCASC 1004
KD K C +V++ + C Y++ CC +C
Sbjct: 1084 KDVNKVAYCPLVLKFKFCSRAYFRQMCCKTC 1114
Score = 124 bits (312), Expect = 3e-28
Identities = 75/232 (32%), Positives = 105/232 (45%), Gaps = 10/232 (4%)
Query: 621 WKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPCPAFW 680
W +ECS TC G Q C + +YCD KP + CN PCP W
Sbjct: 844 WNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEW 903
Query: 681 DIGEWSECSKTCGLGMQHRQVLC-RQVYANRSLTVQPYRCQHLEKPETTSTCQLKICSEW 739
IG+W ECSKTC GM+ R VLC R++ + T+ C +P C + C
Sbjct: 904 FIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCL-THRPVEKEPCNNQSCPPQ 962
Query: 740 QIRTDWTSCSVPCGVGQRTRDVKC-VSNIGDVVDDEECNMKLRPNDIENCDMGPC-AKSW 797
+ DW+ C+ CG G + R V C S++ +C + +P C +G C W
Sbjct: 963 WVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRW 1022
Query: 798 FLTEWSERCSAECGAGVRTRSVVCM--TNHVSSLPLEGCGNNRPAEATPCDN 847
+W + CSA+CG G + R+V C+ T SS LE RP C++
Sbjct: 1023 VTGDWGQ-CSAQCGLGQQMRTVQCLSYTGQASSDCLE---TVRPPSMQQCES 1070
Score = 100 bits (249), Expect = 7e-21
Identities = 59/181 (32%), Positives = 85/181 (46%), Gaps = 11/181 (6%)
Query: 796 SWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGC---GNNRPAEATPCDNGPCTG 852
+W WSE CSA C GV+ + VVC +S+ + P C+ PC
Sbjct: 843 TWNHQPWSE-CSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPP 901
Query: 853 KVEWFAGSWSQCSIECGSGTQQREVICVRK-NADTFEVLDPSECSFLEKPPSQQSCHLKP 911
EWF G W +CS C G + R V+C+RK E LD S C +P ++ C+ +
Sbjct: 902 --EWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGC-LTHRPVEKEPCNNQS 958
Query: 912 CGAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTL---SNLCDPQLKPEERESCNPQDCV 968
C +W + +WS C+ C GF+ R V C S D++ + C + KP R C+ C
Sbjct: 959 CPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCP 1018
Query: 969 P 969
P
Sbjct: 1019 P 1019
Score = 91.7 bits (226), Expect = 3e-18
Identities = 45/121 (37%), Positives = 66/121 (54%), Gaps = 8/121 (6%)
Query: 856 WFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPP-SQQSCHLKPCGA 914
W WS+CS C G Q++EV+C K D ++ + C KPP +Q++C+ +PC
Sbjct: 844 WNHQPWSECSATCAGGVQRQEVVC--KRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPP 901
Query: 915 KWFSTEWSMCSKSCQGGFRVREVRCL-----SDDMTLSNLCDPQLKPEERESCNPQDCVP 969
+WF +W CSK+C GG R R V C+ S++ TL +P E+E CN Q C P
Sbjct: 902 EWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPP 961
Query: 970 E 970
+
Sbjct: 962 Q 962
Score = 50.4 bits (119), Expect = 8e-06
Identities = 26/62 (41%), Positives = 35/62 (56%), Gaps = 4/62 (6%)
Query: 913 GAKWFSTEWSMCSKSCQGGFRVREVRC--LSDD-MTLSNLCDPQLK-PEERESCNPQDCV 968
G W WS CS +C GG + +EV C L D+ + +N CDP K PE + +CN + C
Sbjct: 841 GFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCP 900
Query: 969 PE 970
PE
Sbjct: 901 PE 902
Score = 39.7 bits (91), Expect = 0.015
Identities = 14/27 (51%), Positives = 15/27 (55%)
Query: 54 GVWGAWGPWSACSRSCSGGVMEQTRPC 80
G WG W W CSR+C GGV R C
Sbjct: 559 GGWGPWSLWGECSRTCGGGVSSSLRHC 585
Score = 32.0 bits (71), Expect = 3.0
Identities = 15/34 (44%), Positives = 17/34 (50%), Gaps = 2/34 (5%)
Query: 49 GGGAPGVWGAWG--PWSACSRSCSGGVMEQTRPC 80
G G V W PWS CS +C+GGV Q C
Sbjct: 834 GSGDNEVGFTWNHQPWSECSATCAGGVQRQEVVC 867
>gi|56121815 ADAM metallopeptidase with thrombospondin type 1 motif,
10 preproprotein [Homo sapiens]
Length = 1103
Score = 266 bits (680), Expect = 7e-71
Identities = 170/505 (33%), Positives = 245/505 (48%), Gaps = 42/505 (8%)
Query: 291 CIGAYRQYKLCNTNVCPESSRSIREVQCASYNNKPFMGRFYEWEPFAEVKGNRKCELNCQ 350
C+G R+++ CNT+ CP S+ REVQC+ +++ PF G+FY+W+ + G + C L C
Sbjct: 586 CLGERRRHRSCNTDDCPPGSQDFREVQCSEFDSIPFRGKFYKWKTYRG-GGVKACSLTCL 644
Query: 351 AMGYRFYVRQAEKVIDGTPCDQNGTAICVSGQCKSIGCDDYLGSDKVVDKCGVCGGDNTG 410
A G+ FY +A V+DGTPC + ICVSG+CK +GCD LGSD DKC VCGGD +
Sbjct: 645 AEGFNFYTERAAAVVDGTPCRPDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSA 704
Query: 411 CQVVSGVFKHALTSLGYHRVVEIPEGATKINITEMYKSNNYLALRSRSGRSIINGNWAID 470
C+ + GVF A GY VV IP+G+ I I ++ S ++LAL+ ++ G
Sbjct: 705 CETIEGVFSPASPGAGYEDVVWIPKGSVHIFIQDLNLSLSHLALKGDQESLLLEGLPGTP 764
Query: 471 RPGKYEGGGTMFTYKR-PNEISSTAGESFLAEGPTNEILDVYMIHQQPNPGVHYEYVIMG 529
+P + GT F ++ P+++ +S A GP N L V ++ + P + Y +
Sbjct: 765 QPHRLPLAGTTFQLRQGPDQV-----QSLEALGPINASLIVMVLARTELPALRYRFNAPI 819
Query: 530 TNAISPQVPPHRRPGEPFNGQMVTEGRSQEEGEQKGRNEEKEDLRGEAPEMFTSESAQTF 589
P H P + Q G SQ + + RN+ D AP ++ S
Sbjct: 820 ARDSLPPYSWHYAPWTKCSAQCA--GGSQVQAVE-CRNQ--LDSSAVAPHYCSAHS---- 870
Query: 590 PVRHPDRFSPHRPDNLVPPAPQPPRRSRDHNWKQLGTTECSTTCGKGSQYPIFRCVHRST 649
+ P R R N P P +W + CS +C G + C R +
Sbjct: 871 --KLPKR---QRACNTEPCPP---------DWVVGNWSLCSRSCDAGVRSRSVVCQRRVS 916
Query: 650 HEEAPESYCDSSMKPTPEE---EPCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQV 706
A E D S P P E C+ CP W +WSEC+ +CG G++HR VLC+
Sbjct: 917 --AAEEKALDDSACPQPRPPVLEACHGPTCPPEWAALDWSECTPSCGPGLRHRVVLCKS- 973
Query: 707 YANRSLTVQPYRCQHLEKPETTSTCQLKIC--SEWQIRTDWTSCSVPCGVGQRTRDVKCV 764
A+ T+ P C KP T C L+ C + W + +W CS CGVGQR R V+C
Sbjct: 974 -ADHRATLPPAHCSPAAKPPATMRCNLRRCPPARW-VAGEWGECSAQCGVGQRQRSVRCT 1031
Query: 765 SNIGDVVDDEECNMKLRPNDIENCD 789
S+ G EC LRP + C+
Sbjct: 1032 SHTGQA--SHECTEALRPPTTQQCE 1054
Score = 154 bits (390), Expect = 3e-37
Identities = 92/272 (33%), Positives = 126/272 (46%), Gaps = 17/272 (6%)
Query: 745 WTSCSVPCGVGQRTRDVKCVSNI-GDVVDDEECNMKLR-PNDIENCDMGPCAKSWFLTEW 802
WT CS C G + + V+C + + V C+ + P C+ PC W + W
Sbjct: 834 WTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWVVGNW 893
Query: 803 SERCSAECGAGVRTRSVVCMTN----HVSSLPLEGCGNNRPAEATPCDNGPCTGKVEWFA 858
S CS C AGVR+RSVVC +L C RP C C EW A
Sbjct: 894 S-LCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACHGPTCPP--EWAA 950
Query: 859 GSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPCG-AKWF 917
WS+C+ CG G + R V+C K+AD L P+ CS KPP+ C+L+ C A+W
Sbjct: 951 LDWSECTPSCGPGLRHRVVLC--KSADHRATLPPAHCSPAAKPPATMRCNLRRCPPARWV 1008
Query: 918 STEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERESCNPQDCVP---EVDEN 974
+ EW CS C G R R VRC S S+ C L+P + C + P + E
Sbjct: 1009 AGEWGECSAQCGVGQRQRSVRCTSHTGQASHECTEALRPPTTQQCEAKCDSPTPGDGPEE 1068
Query: 975 CKD--KYYNCNVVVQARLCVYNYYKTACCASC 1004
CKD K C +V++ + C Y++ CC +C
Sbjct: 1069 CKDVNKVAYCPLVLKFQFCSRAYFRQMCCKTC 1100
Score = 102 bits (254), Expect = 2e-21
Identities = 61/181 (33%), Positives = 85/181 (46%), Gaps = 11/181 (6%)
Query: 796 SWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLE---GCGNNRPAEATPCDNGPCTG 852
SW W+ +CSA+C G + ++V C SS + P C+ PC
Sbjct: 828 SWHYAPWT-KCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPP 886
Query: 853 KVEWFAGSWSQCSIECGSGTQQREVICVRK-NADTFEVLDPSECSFLEKPPSQQSCHLKP 911
+W G+WS CS C +G + R V+C R+ +A + LD S C +PP ++CH
Sbjct: 887 --DWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACP-QPRPPVLEACHGPT 943
Query: 912 CGAKWFSTEWSMCSKSCQGGFRVREVRCLSDD--MTLSNL-CDPQLKPEERESCNPQDCV 968
C +W + +WS C+ SC G R R V C S D TL C P KP CN + C
Sbjct: 944 CPPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCP 1003
Query: 969 P 969
P
Sbjct: 1004 P 1004
Score = 79.3 bits (194), Expect = 2e-14
Identities = 42/121 (34%), Positives = 61/121 (50%), Gaps = 8/121 (6%)
Query: 856 WFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEK-PPSQQSCHLKPCGA 914
W W++CS +C G+Q + V C R D+ V P CS K P Q++C+ +PC
Sbjct: 829 WHYAPWTKCSAQCAGGSQVQAVEC-RNQLDSSAVA-PHYCSAHSKLPKRQRACNTEPCPP 886
Query: 915 KWFSTEWSMCSKSCQGGFRVREVRC-----LSDDMTLSNLCDPQLKPEERESCNPQDCVP 969
W WS+CS+SC G R R V C +++ L + PQ +P E+C+ C P
Sbjct: 887 DWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACHGPTCPP 946
Query: 970 E 970
E
Sbjct: 947 E 947
Score = 46.2 bits (108), Expect = 2e-04
Identities = 16/30 (53%), Positives = 18/30 (60%)
Query: 51 GAPGVWGAWGPWSACSRSCSGGVMEQTRPC 80
G G WG W PW CSR+C GGV +R C
Sbjct: 545 GVDGAWGPWTPWGDCSRTCGGGVSSSSRHC 574
Score = 34.7 bits (78), Expect = 0.47
Identities = 23/64 (35%), Positives = 28/64 (43%), Gaps = 13/64 (20%)
Query: 23 VCPQPSTQHRKVPQRMAA---EGAPEDDGGGGAPGVWGAWGPWSACSRSCSGGVMEQTRP 79
V P + H K+P+R A E P D W G WS CSRSC GV ++
Sbjct: 861 VAPHYCSAHSKLPKRQRACNTEPCPPD---------WVV-GNWSLCSRSCDAGVRSRSVV 910
Query: 80 CLPR 83
C R
Sbjct: 911 CQRR 914
Score = 30.4 bits (67), Expect = 8.9
Identities = 17/52 (32%), Positives = 22/52 (42%), Gaps = 3/52 (5%)
Query: 919 TEWSMCSKSCQGGFRVREVRCLSDDMTL-SNLCDPQLKPEERESCNPQDCVP 969
T W CS++C GG C S T+ C + + SCN DC P
Sbjct: 554 TPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERR--RHRSCNTDDCPP 603
>gi|223718260 ADAMTS-like 2 precursor [Homo sapiens]
Length = 951
Score = 236 bits (603), Expect = 6e-62
Identities = 139/435 (31%), Positives = 205/435 (47%), Gaps = 28/435 (6%)
Query: 578 PEMFTSESAQTFPVRHPDRFSPHRPDNLVPPAPQPPRRSRDHNWKQLGTTECSTTCGKGS 637
P + TS H R P V PA + WK CS TC G
Sbjct: 532 PNVSTSLLTSAGNRTHKARTRPKARKQGVSPADM-------YRWKLSSHEPCSATCTTGV 584
Query: 638 QYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPCPAFWDIGEWSECSKTCGLGMQ 697
CV R E +SYCD+ +P P E C C W+ WSECS+TCG G Q
Sbjct: 585 MSAYAMCV-RYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQ 643
Query: 698 HRQVLC-RQVYANRSLTVQPYRCQHLE--KPETTSTCQLKICS-EWQIRTDWTSCSVPCG 753
R V C + + +V C+ E +PE TC+ C +W++ ++W+ C+ CG
Sbjct: 644 FRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEM-SEWSECTAKCG 702
Query: 754 V-GQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCDMGPCAKSWFLTEWSERCSAECGA 812
TRD++C D++ C+ RP +NC PC + W +++W CS CG
Sbjct: 703 ERSVVTRDIRCSE------DEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGP-CSGSCGQ 755
Query: 813 GVRTRSVVCMTNHVSSLPLEGCG-NNRPAEATPCDNGPCTGKVEWFAGSWSQCSIECGSG 871
G R V C T+ +P C +P PC + C W A W +C+ CG G
Sbjct: 756 GRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNC--PAHWLAQDWERCNTTCGRG 813
Query: 872 TQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPCGAKWFSTEWSMCSKSCQGG 931
++R V+C+ + EC +KPP + +C +PC KW+++ WS C+K+C G
Sbjct: 814 VKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPC-FKWYTSPWSECTKTCGVG 872
Query: 932 FRVREVRCLSDDMTLSNLCDPQLKPEERESCNPQDCVPE-VDENCKDK-YYNCNVVVQAR 989
R+R+V+C + CDP +KP R++C+ Q C E D++C+D+ NC + ++
Sbjct: 873 VRMRDVKCYQGTDIVRG-CDPLVKPVGRQACDLQPCPTEPPDDSCQDQPGTNCALAIKVN 931
Query: 990 LCVYNYYKTACCASC 1004
LC + YY ACC SC
Sbjct: 932 LCGHWYYSKACCRSC 946
Score = 173 bits (439), Expect = 6e-43
Identities = 94/264 (35%), Positives = 140/264 (53%), Gaps = 18/264 (6%)
Query: 290 SCIGAYRQYKLCNTNVCPESSRSIREVQCASYNNKPFMGRFYEWEPFAEVK----GNRKC 345
+C G ++Y+LC CP RS RE QC S+N+ + GR ++W+P ++ C
Sbjct: 89 TCTGTSKRYQLCRVQECPPDGRSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPC 148
Query: 346 ELNCQAM-GYRFYVRQAEKVIDGTPCDQNGT-AICVSGQCKSIGCDDYLGSDKVVDKCGV 403
+L+C + G R + A DGT C +CVSG+C+ IGCD L S +DKCG+
Sbjct: 149 DLHCTTVDGQRQLMVPAR---DGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGI 205
Query: 404 CGGDNTGCQVVSGVFKHALTSLGYHRVVEIPEGATKINITEMYKSNNYLALRSRSGRSII 463
C GD + C V+G ++ LGY V IP GA I I E KS + LAL +G
Sbjct: 206 CQGDGSSCTHVTGNYRKGNAHLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFF 265
Query: 464 NGNWAIDRPGKYEGGGTMFTYKRPNEISSTAGESFLAEGPTNEILDVYMIHQQ-PNPGVH 522
NGN+ +D P + GT+ Y+RP ++ T E +A+GPTN+ L+V + +Q +P +
Sbjct: 266 NGNYKVDSPKNFNIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSIT 325
Query: 523 YEYVIMGTNAISPQVPPHRRPGEP 546
+EY ++ PPH +P
Sbjct: 326 FEYTLL--------QPPHESRPQP 341
Score = 45.8 bits (107), Expect = 2e-04
Identities = 20/36 (55%), Positives = 22/36 (61%), Gaps = 1/36 (2%)
Query: 47 DGGGGAPGVW-GAWGPWSACSRSCSGGVMEQTRPCL 81
+GG A W G W W+ACSRSC GGV Q R CL
Sbjct: 40 EGGTDATAFWWGEWTKWTACSRSCGGGVTSQERHCL 75
Score = 31.6 bits (70), Expect = 4.0
Identities = 32/124 (25%), Positives = 48/124 (38%), Gaps = 24/124 (19%)
Query: 768 GDVVDDEECNMKLRPNDIENCDMGPCAKSWFLTEWSE--RCSAECGAGVRTRSVVCMTNH 825
GD V + N +E G A +++ EW++ CS CG GV ++ C+
Sbjct: 22 GDTVSTGSTDNSPTSNSLEG---GTDATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQR 78
Query: 826 VSSLPLEGCGNNRPAEATPCDNGPCTGKVEWFAGSWSQCSI-EC-GSGTQQREVICVRKN 883
S+P G N CTG + + C + EC G RE CV N
Sbjct: 79 RKSVPGPG-------------NRTCTGT----SKRYQLCRVQECPPDGRSFREEQCVSFN 121
Query: 884 ADTF 887
+ +
Sbjct: 122 SHVY 125
Score = 30.8 bits (68), Expect = 6.8
Identities = 17/57 (29%), Positives = 25/57 (43%), Gaps = 7/57 (12%)
Query: 919 TEWSMCSKSCQGGFRVREVRCLSDDMTL-----SNLCDPQLKPEERESCNPQDCVPE 970
T+W+ CS+SC GG +E CL + C K + C Q+C P+
Sbjct: 54 TKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSK--RYQLCRVQECPPD 108
>gi|41281450 ADAMTS-like 2 precursor [Homo sapiens]
Length = 951
Score = 236 bits (603), Expect = 6e-62
Identities = 139/435 (31%), Positives = 205/435 (47%), Gaps = 28/435 (6%)
Query: 578 PEMFTSESAQTFPVRHPDRFSPHRPDNLVPPAPQPPRRSRDHNWKQLGTTECSTTCGKGS 637
P + TS H R P V PA + WK CS TC G
Sbjct: 532 PNVSTSLLTSAGNRTHKARTRPKARKQGVSPADM-------YRWKLSSHEPCSATCTTGV 584
Query: 638 QYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPCPAFWDIGEWSECSKTCGLGMQ 697
CV R E +SYCD+ +P P E C C W+ WSECS+TCG G Q
Sbjct: 585 MSAYAMCV-RYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQ 643
Query: 698 HRQVLC-RQVYANRSLTVQPYRCQHLE--KPETTSTCQLKICS-EWQIRTDWTSCSVPCG 753
R V C + + +V C+ E +PE TC+ C +W++ ++W+ C+ CG
Sbjct: 644 FRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEM-SEWSECTAKCG 702
Query: 754 V-GQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCDMGPCAKSWFLTEWSERCSAECGA 812
TRD++C D++ C+ RP +NC PC + W +++W CS CG
Sbjct: 703 ERSVVTRDIRCSE------DEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGP-CSGSCGQ 755
Query: 813 GVRTRSVVCMTNHVSSLPLEGCG-NNRPAEATPCDNGPCTGKVEWFAGSWSQCSIECGSG 871
G R V C T+ +P C +P PC + C W A W +C+ CG G
Sbjct: 756 GRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNC--PAHWLAQDWERCNTTCGRG 813
Query: 872 TQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPCGAKWFSTEWSMCSKSCQGG 931
++R V+C+ + EC +KPP + +C +PC KW+++ WS C+K+C G
Sbjct: 814 VKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPC-FKWYTSPWSECTKTCGVG 872
Query: 932 FRVREVRCLSDDMTLSNLCDPQLKPEERESCNPQDCVPE-VDENCKDK-YYNCNVVVQAR 989
R+R+V+C + CDP +KP R++C+ Q C E D++C+D+ NC + ++
Sbjct: 873 VRMRDVKCYQGTDIVRG-CDPLVKPVGRQACDLQPCPTEPPDDSCQDQPGTNCALAIKVN 931
Query: 990 LCVYNYYKTACCASC 1004
LC + YY ACC SC
Sbjct: 932 LCGHWYYSKACCRSC 946
Score = 173 bits (439), Expect = 6e-43
Identities = 94/264 (35%), Positives = 140/264 (53%), Gaps = 18/264 (6%)
Query: 290 SCIGAYRQYKLCNTNVCPESSRSIREVQCASYNNKPFMGRFYEWEPFAEVK----GNRKC 345
+C G ++Y+LC CP RS RE QC S+N+ + GR ++W+P ++ C
Sbjct: 89 TCTGTSKRYQLCRVQECPPDGRSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPC 148
Query: 346 ELNCQAM-GYRFYVRQAEKVIDGTPCDQNGT-AICVSGQCKSIGCDDYLGSDKVVDKCGV 403
+L+C + G R + A DGT C +CVSG+C+ IGCD L S +DKCG+
Sbjct: 149 DLHCTTVDGQRQLMVPAR---DGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGI 205
Query: 404 CGGDNTGCQVVSGVFKHALTSLGYHRVVEIPEGATKINITEMYKSNNYLALRSRSGRSII 463
C GD + C V+G ++ LGY V IP GA I I E KS + LAL +G
Sbjct: 206 CQGDGSSCTHVTGNYRKGNAHLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFF 265
Query: 464 NGNWAIDRPGKYEGGGTMFTYKRPNEISSTAGESFLAEGPTNEILDVYMIHQQ-PNPGVH 522
NGN+ +D P + GT+ Y+RP ++ T E +A+GPTN+ L+V + +Q +P +
Sbjct: 266 NGNYKVDSPKNFNIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSIT 325
Query: 523 YEYVIMGTNAISPQVPPHRRPGEP 546
+EY ++ PPH +P
Sbjct: 326 FEYTLL--------QPPHESRPQP 341
Score = 45.8 bits (107), Expect = 2e-04
Identities = 20/36 (55%), Positives = 22/36 (61%), Gaps = 1/36 (2%)
Query: 47 DGGGGAPGVW-GAWGPWSACSRSCSGGVMEQTRPCL 81
+GG A W G W W+ACSRSC GGV Q R CL
Sbjct: 40 EGGTDATAFWWGEWTKWTACSRSCGGGVTSQERHCL 75
Score = 31.6 bits (70), Expect = 4.0
Identities = 32/124 (25%), Positives = 48/124 (38%), Gaps = 24/124 (19%)
Query: 768 GDVVDDEECNMKLRPNDIENCDMGPCAKSWFLTEWSE--RCSAECGAGVRTRSVVCMTNH 825
GD V + N +E G A +++ EW++ CS CG GV ++ C+
Sbjct: 22 GDTVSTGSTDNSPTSNSLEG---GTDATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQR 78
Query: 826 VSSLPLEGCGNNRPAEATPCDNGPCTGKVEWFAGSWSQCSI-EC-GSGTQQREVICVRKN 883
S+P G N CTG + + C + EC G RE CV N
Sbjct: 79 RKSVPGPG-------------NRTCTGT----SKRYQLCRVQECPPDGRSFREEQCVSFN 121
Query: 884 ADTF 887
+ +
Sbjct: 122 SHVY 125
Score = 30.8 bits (68), Expect = 6.8
Identities = 17/57 (29%), Positives = 25/57 (43%), Gaps = 7/57 (12%)
Query: 919 TEWSMCSKSCQGGFRVREVRCLSDDMTL-----SNLCDPQLKPEERESCNPQDCVPE 970
T+W+ CS+SC GG +E CL + C K + C Q+C P+
Sbjct: 54 TKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSK--RYQLCRVQECPPD 108
>gi|169174934 PREDICTED: similar to ADAMTS-like 2 [Homo sapiens]
Length = 660
Score = 236 bits (603), Expect = 6e-62
Identities = 139/435 (31%), Positives = 205/435 (47%), Gaps = 28/435 (6%)
Query: 578 PEMFTSESAQTFPVRHPDRFSPHRPDNLVPPAPQPPRRSRDHNWKQLGTTECSTTCGKGS 637
P + TS H R P V PA + WK CS TC G
Sbjct: 241 PNVSTSLLTSAGNRTHKARTRPKARKQGVSPADM-------YRWKLSSHEPCSATCTTGV 293
Query: 638 QYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPCPAFWDIGEWSECSKTCGLGMQ 697
CV R E +SYCD+ +P P E C C W+ WSECS+TCG G Q
Sbjct: 294 MSAYAMCV-RYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQ 352
Query: 698 HRQVLC-RQVYANRSLTVQPYRCQHLE--KPETTSTCQLKICS-EWQIRTDWTSCSVPCG 753
R V C + + +V C+ E +PE TC+ C +W++ ++W+ C+ CG
Sbjct: 353 FRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEM-SEWSECTAKCG 411
Query: 754 V-GQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCDMGPCAKSWFLTEWSERCSAECGA 812
TRD++C D++ C+ RP +NC PC + W +++W CS CG
Sbjct: 412 ERSVVTRDIRCSE------DEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGP-CSGSCGQ 464
Query: 813 GVRTRSVVCMTNHVSSLPLEGCG-NNRPAEATPCDNGPCTGKVEWFAGSWSQCSIECGSG 871
G R V C T+ +P C +P PC + C W A W +C+ CG G
Sbjct: 465 GRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNC--PAHWLAQDWERCNTTCGRG 522
Query: 872 TQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPCGAKWFSTEWSMCSKSCQGG 931
++R V+C+ + EC +KPP + +C +PC KW+++ WS C+K+C G
Sbjct: 523 VKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPC-FKWYTSPWSECTKTCGVG 581
Query: 932 FRVREVRCLSDDMTLSNLCDPQLKPEERESCNPQDCVPE-VDENCKDK-YYNCNVVVQAR 989
R+R+V+C + CDP +KP R++C+ Q C E D++C+D+ NC + ++
Sbjct: 582 VRMRDVKCYQGTDIVRG-CDPLVKPVGRQACDLQPCPTEPPDDSCQDQPGTNCALAIKVN 640
Query: 990 LCVYNYYKTACCASC 1004
LC + YY ACC SC
Sbjct: 641 LCGHWYYSKACCRSC 655
>gi|38683827 ADAM metallopeptidase with thrombospondin type 1 motif, 7
preproprotein [Homo sapiens]
Length = 1686
Score = 232 bits (592), Expect = 1e-60
Identities = 162/489 (33%), Positives = 228/489 (46%), Gaps = 50/489 (10%)
Query: 266 SNNHGVGTHGATQSFSQPA-RSTAISCIGAYRQYKLCNTNVCPESSRSIREVQCASYNNK 324
S + G+G A + +QP + C+G ++++LCN CP S R VQC+ ++
Sbjct: 551 SRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACPAGRPSFRHVQCSHFDAM 610
Query: 325 PFMGRFYEWEPFAEVKGNRKCELNCQAMGYRFYVRQAEKVIDGTPCDQNGTA--ICVSGQ 382
+ G+ + W P V CEL+C+ F + + V+DGTPC Q + +C++G
Sbjct: 611 LYKGQLHTWVPV--VNDVNPCELHCRPANEYFAEKLRDAVVDGTPCYQVRASRDLCINGI 668
Query: 383 CKSIGCDDYLGSDKVVDKCGVCGGDNTGCQVVSGVFKHALTSLGYHRVVEIPEGATKINI 442
CK++GCD + S + D+CGVC G+ + C VSG F+ A LGY V IP GA +I I
Sbjct: 669 CKNVGCDFEIDSGAMEDRCGVCHGNGSTCHTVSGTFEEA-EGLGYVDVGLIPAGAREIRI 727
Query: 443 TEMYKSNNYLALRSRS-GRSIINGNWAIDRPGKYEGGGTMFTYKRPNEISSTAGESFLAE 501
E+ ++ N+LALRS + +NG W I G Y+ GT FTY R E+ +
Sbjct: 728 QEVAEAANFLALRSEDPEKYFLNGGWTIQWNGDYQVAGTTFTYARRGN-----WENLTSP 782
Query: 502 GPTNEILDVYMIHQQPNPGVHYEYVIMGTNAISPQVPPHRRPGE--PFNGQMVTEGRSQE 559
GPT E + + ++ Q+ NPGVHYEY I +VPP P+ VT GR
Sbjct: 783 GPTKEPVWIQLLFQESNPGVHYEYTIHREAGGHDEVPPPVFSWHYGPWTKCTVTCGR--- 839
Query: 560 EGEQKGRNEEKEDLRGEAPEMFTSESAQTFPVRHPDRFSPHRPDNLVPPAPQPPRRSRDH 619
G Q+ E G E H D RPD+ + P +R
Sbjct: 840 -GVQRQNVYCLERQAGPVDE------------EHCDPLG--RPDDQQRKCSEQPCPAR-- 882
Query: 620 NWKQLGTTECSTTCGKGS----QYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCN-IF 674
W CS++CG G R V C+ +P P E PCN
Sbjct: 883 -WWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRP-PTETPCNRHV 940
Query: 675 PCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLK 734
PCPA W +G WS+CS TCG G Q R VLC + T P C ++P + TC L
Sbjct: 941 PCPATWAVGNWSQCSVTCGEGTQRRNVLC------TNDTGVP--CDEAQQPASEVTCSLP 992
Query: 735 ICSEWQIRT 743
+C W + T
Sbjct: 993 LC-RWPLGT 1000
Score = 139 bits (349), Expect = 2e-32
Identities = 88/277 (31%), Positives = 119/277 (42%), Gaps = 32/277 (11%)
Query: 739 WQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCDMGPCAKSWF 798
WQ +W+ CS CG+G R V+C S DE+C RP C + PCA +W
Sbjct: 1415 WQAG-NWSECSTTCGLGAVWRPVRCSSG-----RDEDCAPAGRPQPARRCHLRPCA-TWH 1467
Query: 799 LTEWSERCSAECGAGVRTRSVVCM-TNHVSSLPLEGC--GNNRPAEATPCDNGPCTGKVE 855
WS +CS CG G R V C+ T + L C G +P PC PC +
Sbjct: 1468 SGNWS-KCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPC---LS 1523
Query: 856 WFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPCGAK 915
W+ SW +CS CG G QQR V C +P C +P + + C+ PC +
Sbjct: 1524 WYTSSWRECSEACGGGEQQRLVTCP----------EPGLCEEALRPNTTRPCNTHPC-TQ 1572
Query: 916 WFSTEWSMCSKSCQGGFRVREVRCLSDDMTL----SNLCDPQLKPEERESCNPQDCVPEV 971
W W CS C GG + R V+C++ L S+ C + PE C +DC P
Sbjct: 1573 WVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDCEPVE 1632
Query: 972 DENCKDKYYNCNVVVQARL---CVYNYYKTACCASCT 1005
C+ + RL C +T CC SC+
Sbjct: 1633 PPRCERDRLSFGFCETLRLLGRCQLPTIRTQCCRSCS 1669
Score = 124 bits (310), Expect = 6e-28
Identities = 80/247 (32%), Positives = 100/247 (40%), Gaps = 43/247 (17%)
Query: 678 AFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKICS 737
A W G WSECS TCGLG R V C + + C +P+ C L+ C+
Sbjct: 1413 AGWQAGNWSECSTTCGLGAVWRPVRCS--------SGRDEDCAPAGRPQPARRCHLRPCA 1464
Query: 738 EWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCDMGPC---- 793
W +W+ CS CG G RDV+CV LRP +C GP
Sbjct: 1465 TWH-SGNWSKCSRSCGGGSSVRDVQCVD-----------TRDLRPLRPFHCQPGPAKPPA 1512
Query: 794 --------AKSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNNRPAEATPC 845
SW+ + W E CS CG G + R V C + L RP PC
Sbjct: 1513 HRPCGAQPCLSWYTSSWRE-CSEACGGGEQQRLVTCPEPGLCEEAL------RPNTTRPC 1565
Query: 846 DNGPCTGKVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQ 905
+ PCT +W G W QCS CG G Q+R V CV E D +C P S +
Sbjct: 1566 NTHPCT---QWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEE-DSDQCGHEAWPESSR 1621
Query: 906 SCHLKPC 912
C + C
Sbjct: 1622 PCGTEDC 1628
Score = 120 bits (302), Expect = 5e-27
Identities = 95/306 (31%), Positives = 126/306 (41%), Gaps = 32/306 (10%)
Query: 555 GRSQEEGEQKGRNEEKEDLRGEAP--EMFTSESAQTFPV---RHPDRFSPHRPDNLVPPA 609
G E G + E L E P S A P R P+ P P
Sbjct: 1345 GHMPEPALNPGPKGQPESLSPEVPLSSRLLSTPAWDSPANSHRVPET-QPLAPSLAEAGP 1403
Query: 610 PQPPRRSRDHNWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEE 669
P P R+ W+ +ECSTTCG G+ + RC + C + +P P
Sbjct: 1404 PADPLVVRNAGWQAGNWSECSTTCGLGAVWRPVRC------SSGRDEDCAPAGRPQPARR 1457
Query: 670 PCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQ-HLEKPETT 728
C++ PC A W G WS+CS++CG G R V C R L +P+ CQ KP
Sbjct: 1458 -CHLRPC-ATWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPL--RPFHCQPGPAKPPAH 1513
Query: 729 STCQLKICSEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENC 788
C + C W + W CS CG G++ R V C + C LRPN C
Sbjct: 1514 RPCGAQPCLSW-YTSSWRECSEACGGGEQQRLVTC-------PEPGLCEEALRPNTTRPC 1565
Query: 789 DMGPCAKSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEG---CGNNR-PAEATP 844
+ PC + W + W + CS CG GV+ R V C+ N + LP E CG+ P + P
Sbjct: 1566 NTHPCTQ-WVVGPWGQ-CSGPCGGGVQRRLVKCV-NTQTGLPEEDSDQCGHEAWPESSRP 1622
Query: 845 CDNGPC 850
C C
Sbjct: 1623 CGTEDC 1628
Score = 107 bits (267), Expect = 6e-23
Identities = 61/176 (34%), Positives = 89/176 (50%), Gaps = 19/176 (10%)
Query: 745 WTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIEN-CDMGPCAKSWFLTEWS 803
WT C+V CG G + ++V C+ VD+E C+ RP+D + C PC W+ EW
Sbjct: 830 WTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCPARWWAGEW- 888
Query: 804 ERCSAECG-AGVRTRSVVCMTN----HVSSLPLEGCGN-NRPAEATPCDNG-PCTGKVEW 856
+ CS+ CG G+ R+V+C+ + S+L C + RP TPC+ PC W
Sbjct: 889 QLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHVPCPAT--W 946
Query: 857 FAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPC 912
G+WSQCS+ CG GTQ+R V+C C ++P S+ +C L C
Sbjct: 947 AVGNWSQCSVTCGEGTQRRNVLCTNDTG--------VPCDEAQQPASEVTCSLPLC 994
Score = 105 bits (261), Expect = 3e-22
Identities = 54/159 (33%), Positives = 81/159 (50%), Gaps = 4/159 (2%)
Query: 620 NWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPCPAF 679
+W T+C+ TCG+G Q C+ R E +CD +P ++ C+ PCPA
Sbjct: 824 SWHYGPWTKCTVTCGRGVQRQNVYCLERQAGP-VDEEHCDPLGRPDDQQRKCSEQPCPAR 882
Query: 680 WDIGEWSECSKTCGL-GMQHRQVLC-RQVYANRSLTVQPYRCQHLEKPETTSTCQLKI-C 736
W GEW CS +CG G+ R VLC R V + ++P C+HL +P T + C + C
Sbjct: 883 WWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHVPC 942
Query: 737 SEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEE 775
+W+ CSV CG G + R+V C ++ G D+ +
Sbjct: 943 PATWAVGNWSQCSVTCGEGTQRRNVLCTNDTGVPCDEAQ 981
Score = 100 bits (249), Expect = 7e-21
Identities = 58/184 (31%), Positives = 85/184 (46%), Gaps = 11/184 (5%)
Query: 789 DMGPCAKSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCGN-NRPAEAT-PCD 846
++ P SW W+ +C+ CG GV+ ++V C+ + E C RP + C
Sbjct: 817 EVPPPVFSWHYGPWT-KCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCS 875
Query: 847 NGPCTGKVEWFAGSWSQCSIECG-SGTQQREVICVRK-NADTFEVLDPSECSFLEKPPSQ 904
PC + W+AG W CS CG G +R V+C+R D L+P C L +PP++
Sbjct: 876 EQPCPAR--WWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTE 933
Query: 905 QSCHLK-PCGAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERESCN 963
C+ PC A W WS CS +C G + R V C +D CD +P +C+
Sbjct: 934 TPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLCTND---TGVPCDEAQQPASEVTCS 990
Query: 964 PQDC 967
C
Sbjct: 991 LPLC 994
Score = 81.6 bits (200), Expect = 3e-15
Identities = 53/156 (33%), Positives = 70/156 (44%), Gaps = 15/156 (9%)
Query: 840 AEATPCDNGPCTGKVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLE 899
AEA P + W AG+WS+CS CG G R V C + +C+
Sbjct: 1399 AEAGPPADPLVVRNAGWQAGNWSECSTTCGLGAVWRPVRCSSGRDE--------DCAPAG 1450
Query: 900 KPPSQQSCHLKPCGAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNL----CDP-QL 954
+P + CHL+PC A W S WS CS+SC GG VR+V+C+ D L L C P
Sbjct: 1451 RPQPARRCHLRPC-ATWHSGNWSKCSRSCGGGSSVRDVQCV-DTRDLRPLRPFHCQPGPA 1508
Query: 955 KPEERESCNPQDCVPEVDENCKDKYYNCNVVVQARL 990
KP C Q C+ + ++ C Q RL
Sbjct: 1509 KPPAHRPCGAQPCLSWYTSSWRECSEACGGGEQQRL 1544
Score = 39.3 bits (90), Expect = 0.019
Identities = 15/36 (41%), Positives = 18/36 (50%)
Query: 54 GVWGAWGPWSACSRSCSGGVMEQTRPCLPRSYRLRG 89
G W W WS CSRSC GV R C + + +G
Sbjct: 539 GGWSGWSAWSICSRSCGMGVQSAERQCTQPTPKYKG 574
Score = 30.4 bits (67), Expect = 8.9
Identities = 11/25 (44%), Positives = 15/25 (60%)
Query: 59 WGPWSACSRSCSGGVMEQTRPCLPR 83
+GPW+ C+ +C GV Q CL R
Sbjct: 827 YGPWTKCTVTCGRGVQRQNVYCLER 851
>gi|145309328 papilin [Homo sapiens]
Length = 1251
Score = 228 bits (582), Expect = 2e-59
Identities = 160/521 (30%), Positives = 217/521 (41%), Gaps = 79/521 (15%)
Query: 285 RSTAISCIGAYRQYKLCNTNVCPESSRSIREVQCASYNNKPFMGRFYEWEPFAEVKGNRK 344
R SC+G R ++ C T CP+ +R R QCA ++ F GR Y W P+ K
Sbjct: 58 RDGGSSCVGPARSHRSCRTESCPDGARDFRAEQCAEFDGAEFQGRRYRWLPYYSAPN--K 115
Query: 345 CELNCQAMGYRFYVRQAEKVIDGTPCDQNGTAICVSGQCKSIGCDDYLGSDKVVDKCGVC 404
CELNC G FY + E V+DGTPC+ +CV G C+ +GCD L S K DKC C
Sbjct: 116 CELNCIPKGENFYYKHREAVVDGTPCEPGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRC 175
Query: 405 GGDNTGCQVVSGVFKHALTSLGYHRVVEIPEGATKINITEMYKSNNYLALRSRSGRSIIN 464
GGD T C V+G F ++ A+++ G +N
Sbjct: 176 GGDGTTCYPVAGTFD---------------------------ANDLSRAVKNVRGEYYLN 208
Query: 465 GNWAIDRPGKYEGGGTMFTYKRPNEISSTAGESFLAEGPTNEILDVYMIHQQPNPGVHYE 524
G+W I+ T+ Y+R E A E A GPT+E L + +I Q+PNPGVHYE
Sbjct: 209 GHWTIEAARALPAASTILHYERGAE-GDLAPERLHARGPTSEPLVIELISQEPNPGVHYE 267
Query: 525 YVIMGTNAISPQVPPHRRPGEPFNGQMVTEGRSQEEGEQKGRNEEKEDLRGEAPEMFTSE 584
Y + P RRP F+ S E G ++ + E +
Sbjct: 268 YHL-----------PLRRPSPGFSWS--HGSWSDCSAECGGGHQSRLVFCTIDHEAYPDH 314
Query: 585 SAQTFPVRHPDRFSPHRPDNLVPPAPQPPRRSRDHNWKQLGTTECSTTCGKGSQYPIFRC 644
Q P R DR S + + P P+ R WK CS +CG GSQ C
Sbjct: 315 MCQRQP-RPADRRSCN-----LHPCPETKR------WKAGPWAPCSASCGGGSQSRSVYC 362
Query: 645 VH---RSTHEEAPESYCDSSMKPTPEEEPCNIFPCPAFWDIGEWSECSKTCGLGMQHRQV 701
+ E E+ C P + CN+ C A W W ECS +CG+G++ R V
Sbjct: 363 ISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRCAA-WSPEPWGECSVSCGVGVRKRSV 421
Query: 702 LCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKIC-----SEWQIRTDWTSCSVPCGVGQ 756
CR R + C ++P T C + C W + T W CS C G
Sbjct: 422 TCR---GERGSLLHTAACSLEDRPPLTEPCVHEDCPLLSDQAWHVGT-WGLCSKSCSSGT 477
Query: 757 RTRDVKCV----SNIGDVVDDEECNMKLRPNDIENCDMGPC 793
R R V C S+ G + +P D+E C+ PC
Sbjct: 478 RRRQVICAIGPPSHCGSL-------QHSKPVDVEPCNTQPC 511
Score = 140 bits (352), Expect = 8e-33
Identities = 88/255 (34%), Positives = 120/255 (47%), Gaps = 35/255 (13%)
Query: 675 PCPAF-WDIGEWSECSKTCGLGMQHRQVLC---RQVYANRSLTVQPYRCQHLEKPETTST 730
P P F W G WS+CS CG G Q R V C + Y + + CQ +P +
Sbjct: 275 PSPGFSWSHGSWSDCSAECGGGHQSRLVFCTIDHEAYPD-------HMCQRQPRPADRRS 327
Query: 731 CQLKICSE---WQIRTDWTSCSVPCGVGQRTRDVKCVSNIG----DVVDDEEC-NMKLRP 782
C L C E W+ W CS CG G ++R V C+S+ G + V++ EC + +P
Sbjct: 328 CNLHPCPETKRWKAGP-WAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKP 386
Query: 783 NDIENCDMGPCAKSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCG-NNRPAE 841
I+ C++ CA +W W E CS CG GVR RSV C S L C +RP
Sbjct: 387 PAIQACNLQRCA-AWSPEPWGE-CSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPL 444
Query: 842 ATPC--DNGPCTGKVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLE 899
PC ++ P W G+W CS C SGT++R+VIC + PS C L+
Sbjct: 445 TEPCVHEDCPLLSDQAWHVGTWGLCSKSCSSGTRRRQVICA--------IGPPSHCGSLQ 496
Query: 900 --KPPSQQSCHLKPC 912
KP + C+ +PC
Sbjct: 497 HSKPVDVEPCNTQPC 511
Score = 115 bits (289), Expect = 2e-25
Identities = 67/177 (37%), Positives = 92/177 (51%), Gaps = 8/177 (4%)
Query: 796 SWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNN-RPAEATPCDNGPCTGKV 854
SW WS+ CSAECG G ++R V C +H + P C RPA+ C+ PC
Sbjct: 280 SWSHGSWSD-CSAECGGGHQSRLVFCTIDH-EAYPDHMCQRQPRPADRRSCNLHPCPETK 337
Query: 855 EWFAGSWSQCSIECGSGTQQREVICVRKN-ADTFEVLDPSECSFLE-KPPSQQSCHLKPC 912
W AG W+ CS CG G+Q R V C+ + A E ++ +EC+ L KPP+ Q+C+L+ C
Sbjct: 338 RWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRC 397
Query: 913 GAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTL--SNLCDPQLKPEERESCNPQDC 967
A W W CS SC G R R V C + +L + C + +P E C +DC
Sbjct: 398 AA-WSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHEDC 453
Score = 115 bits (289), Expect = 2e-25
Identities = 74/242 (30%), Positives = 106/242 (43%), Gaps = 35/242 (14%)
Query: 745 WTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCDMGPC--AKSWFLTEW 802
W+ CS CG G ++R V C + + D C + RP D +C++ PC K W W
Sbjct: 286 WSDCSAECGGGHQSRLVFCTID-HEAYPDHMCQRQPRPADRRSCNLHPCPETKRWKAGPW 344
Query: 803 SERCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNNRPAEATPCDNGPCTGK--------- 853
+ CSA CG G ++RSV C+++ +G G E C P GK
Sbjct: 345 AP-CSASCGGGSQSRSVYCISS-------DGAGIQEAVEEAECAGLP--GKPPAIQACNL 394
Query: 854 ---VEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLK 910
W W +CS+ CG G ++R V C + +L + CS ++PP + C +
Sbjct: 395 QRCAAWSPEPWGECSVSCGVGVRKRSVTC---RGERGSLLHTAACSLEDRPPLTEPCVHE 451
Query: 911 PC----GAKWFSTEWSMCSKSCQGGFRVREVRC-LSDDMTLSNLCDPQLKPEERESCNPQ 965
C W W +CSKSC G R R+V C + +L KP + E CN Q
Sbjct: 452 DCPLLSDQAWHVGTWGLCSKSCSSGTRRRQVICAIGPPSHCGSL--QHSKPVDVEPCNTQ 509
Query: 966 DC 967
C
Sbjct: 510 PC 511
Score = 77.4 bits (189), Expect = 6e-14
Identities = 47/143 (32%), Positives = 64/143 (44%), Gaps = 13/143 (9%)
Query: 856 WFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPCGA- 914
W GSWS CS ECG G Q R V C + E C +P ++SC+L PC
Sbjct: 281 WSHGSWSDCSAECGGGHQSRLVFCTIDH----EAYPDHMCQRQPRPADRRSCNLHPCPET 336
Query: 915 -KWFSTEWSMCSKSCQGGFRVREVRCLSDD-------MTLSNLCDPQLKPEERESCNPQD 966
+W + W+ CS SC GG + R V C+S D + + KP ++CN Q
Sbjct: 337 KRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQR 396
Query: 967 CVPEVDENCKDKYYNCNVVVQAR 989
C E + +C V V+ R
Sbjct: 397 CAAWSPEPWGECSVSCGVGVRKR 419
Score = 48.9 bits (115), Expect = 2e-05
Identities = 26/57 (45%), Positives = 29/57 (50%), Gaps = 8/57 (14%)
Query: 49 GGGAPGV------WGAWGPWSACSRSCSGGVMEQTRPCLPRSYRLRGGQRPGAPARA 99
G AP V WG W WS CSR+C GGV + RPC S R GG PAR+
Sbjct: 16 GSSAPKVRRQSDTWGPWSQWSPCSRTCGGGVSFRERPCY--SQRRDGGSSCVGPARS 70
Score = 43.5 bits (101), Expect = 0.001
Identities = 21/56 (37%), Positives = 27/56 (48%), Gaps = 1/56 (1%)
Query: 913 GAKWFSTEWSMCSKSCQGGFRVREVRCLSD-DMTLSNLCDPQLKPEERESCNPQDC 967
G W WS CS C GG + R V C D + ++C Q +P +R SCN C
Sbjct: 278 GFSWSHGSWSDCSAECGGGHQSRLVFCTIDHEAYPDHMCQRQPRPADRRSCNLHPC 333
Score = 40.8 bits (94), Expect = 0.007
Identities = 17/42 (40%), Positives = 27/42 (64%), Gaps = 6/42 (14%)
Query: 965 QDCVPEVDENCKDKYYNCNVVVQARLCVYNYYKTACCASCTR 1006
+DCV + + NC++++QA+LC YY + CCASC+R
Sbjct: 1206 RDCVDQPE------LANCDLILQAQLCGNEYYSSFCCASCSR 1241
Score = 31.6 bits (70), Expect = 4.0
Identities = 15/49 (30%), Positives = 22/49 (44%), Gaps = 2/49 (4%)
Query: 919 TEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERESCNPQDC 967
++WS CS++C GG RE C S + C + SC + C
Sbjct: 33 SQWSPCSRTCGGGVSFRERPCYSQRRDGGSSCVGPAR--SHRSCRTESC 79
Score = 31.2 bits (69), Expect = 5.2
Identities = 25/82 (30%), Positives = 33/82 (40%), Gaps = 11/82 (13%)
Query: 861 WSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPC--GAKWFS 918
WS CS CG G RE C + D S + S +SC + C GA+ F
Sbjct: 35 WSPCSRTCGGGVSFRERPCYSQRRD-------GGSSCVGPARSHRSCRTESCPDGARDFR 87
Query: 919 TEWSMCSKSCQGGFRVREVRCL 940
E C++ F+ R R L
Sbjct: 88 AE--QCAEFDGAEFQGRRYRWL 107
Score = 30.4 bits (67), Expect = 8.9
Identities = 12/26 (46%), Positives = 16/26 (61%), Gaps = 1/26 (3%)
Query: 56 WGAWGPWSACSRSCSGGVMEQTRPCL 81
W A GPW+ CS SC GG ++ C+
Sbjct: 339 WKA-GPWAPCSASCGGGSQSRSVYCI 363
>gi|112789555 ADAM metallopeptidase with thrombospondin type 1 motif,
19 preproprotein [Homo sapiens]
Length = 1207
Score = 217 bits (552), Expect = 5e-56
Identities = 149/514 (28%), Positives = 223/514 (43%), Gaps = 41/514 (7%)
Query: 286 STAISCIGAYRQYKLCNTNVCPESSRSIREVQCASYNNKPFMGR-FYEWEPFAEVKGNRK 344
S A C G +QY++C CP R+ QC +Y+ + + +W+ A + +
Sbjct: 665 SEARDCNGPRKQYRICENPPCPAGLPGFRDWQCQAYSVRTSSPKHILQWQ--AVLDEEKP 722
Query: 345 CELNCQAMGYRFYVRQAEKVIDGTPCDQNGTAICVSGQCKSIGCDDYLGSDKVVDKCGVC 404
C L C +G + +EKV+DGT C G IC +G+C+ +GCD LGS D CGVC
Sbjct: 723 CALFCSPVGKEQPILLSEKVMDGTSCGYQGLDICANGRCQKVGCDGLLGSLAREDHCGVC 782
Query: 405 GGDNTGCQVVSGVFKHALTSLGYHRVVEIPEGATKINITEMYKSNNYLALRSRSGRSIIN 464
G+ C+++ G F H GY V+ IP GA +I + E +++YLALR +G+ IN
Sbjct: 783 NGNGKSCKIIKGDFNHT-RGAGYVEVLVIPAGARRIKVVEEKPAHSYLALRD-AGKQSIN 840
Query: 465 GNWAIDRPGKYEGGGTMFTYKRPNEISSTAGESFLAEGPTNEILD-VYMIHQQPNPGVHY 523
+W I+ G + GT Y R E A+GPT L + ++ Q N G+HY
Sbjct: 841 SDWKIEHSGAFNLAGTTVHYVRRG-----LWEKISAKGPTTAPLHLLVLLFQDQNYGLHY 895
Query: 524 EYVIMGTNAISPQVPPHRRPGEPFNGQMVTEGRSQEEGEQKGRNEEKEDLRGEAPEMFTS 583
EY I S +P ++ P M T ++ G E K T+
Sbjct: 896 EYTIP-----SDPLPENQSSKAPEPLFMWTHTSWEDCDATCGGGERK-----------TT 939
Query: 584 ESAQTFPVRHPDRFSPHRPDNLVPPAPQPPRRSR---DHNWKQLGTTECSTTCGKGSQYP 640
S ++ + L P PQ + + W T CS TCGKG Q
Sbjct: 940 VSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSR 999
Query: 641 IFRCVHRSTHEEAPESYCDSSMKPTP-EEEPCNIFPCPAFWDIGEWSECSKTCGLGMQHR 699
C + ++ + + P P + C C W+ G WSECS CG G++HR
Sbjct: 1000 QVACTQQLSNGTLIRARERDCIGPKPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHR 1059
Query: 700 QVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKICSEWQIRTDWTSCSVPCGVGQRTR 759
V C L+ +P + E C W++ DW+ CS+ CG G ++R
Sbjct: 1060 TVRCTNPRKKCVLSTRPREAEDCE--------DYSKCYVWRM-GDWSKCSITCGKGMQSR 1110
Query: 760 DVKCVSNIGDVVDDEECNMKLRPNDIENCDMGPC 793
++C+ I EC +P C + PC
Sbjct: 1111 VIQCMHKITG-RHGNECFSSEKPAAYRPCHLQPC 1143
Score = 137 bits (345), Expect = 5e-32
Identities = 88/259 (33%), Positives = 122/259 (47%), Gaps = 22/259 (8%)
Query: 664 PTPEEEPCNIFPCPAF-WDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHL 722
P PE + P P F W W +C TCG G + V C ++ + V +C++L
Sbjct: 903 PLPENQSSKA-PEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYL 961
Query: 723 EKPETT-STCQLKICSEWQIRTDWTSCSVPCGVGQRTRDVKCVSNI--GDVVDDEECN-M 778
KPE C + C + T+WT CS CG G ++R V C + G ++ E + +
Sbjct: 962 TKPEPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCI 1021
Query: 779 KLRPNDIENCDMGPCAKSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCG-NN 837
+P + C+ C W WSE CS +CG G+R R+V C TN P + C +
Sbjct: 1022 GPKPASAQRCEGQDCMTVWEAGVWSE-CSVKCGKGIRHRTVRC-TN-----PRKKCVLST 1074
Query: 838 RPAEATPC-DNGPCTGKVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECS 896
RP EA C D C W G WS+CSI CG G Q R + C+ K +EC
Sbjct: 1075 RPREAEDCEDYSKC---YVWRMGDWSKCSITCGKGMQSRVIQCMHKITGR----HGNECF 1127
Query: 897 FLEKPPSQQSCHLKPCGAK 915
EKP + + CHL+PC K
Sbjct: 1128 SSEKPAAYRPCHLQPCNEK 1146
Score = 132 bits (333), Expect = 1e-30
Identities = 79/256 (30%), Positives = 114/256 (44%), Gaps = 16/256 (6%)
Query: 602 PDNLVPPAPQPPRRSRDHNWKQLGTTECSTTCGKGSQYPIFRC--VHRSTHEEAPESYCD 659
P+N AP+P W +C TCG G + C + C
Sbjct: 905 PENQSSKAPEPL-----FMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCK 959
Query: 660 SSMKPTPEEEPCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRC 719
KP P+ CN PC W + EW+ CS+TCG GMQ RQV C Q +N +L R
Sbjct: 960 YLTKPEPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERD 1019
Query: 720 QHLEKPETTSTCQLKIC-SEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNM 778
KP + C+ + C + W+ W+ CSV CG G R R V+C + ++C +
Sbjct: 1020 CIGPKPASAQRCEGQDCMTVWEAGV-WSECSVKCGKGIRHRTVRCTN------PRKKCVL 1072
Query: 779 KLRPNDIENCDMGPCAKSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNNR 838
RP + E+C+ W + +WS +CS CG G+++R + CM E + +
Sbjct: 1073 STRPREAEDCEDYSKCYVWRMGDWS-KCSITCGKGMQSRVIQCMHKITGRHGNECFSSEK 1131
Query: 839 PAEATPCDNGPCTGKV 854
PA PC PC K+
Sbjct: 1132 PAAYRPCHLQPCNEKI 1147
Score = 125 bits (314), Expect = 2e-28
Identities = 80/287 (27%), Positives = 118/287 (41%), Gaps = 38/287 (13%)
Query: 743 TDWTSCSVPCGVGQRTRDVKCVSNIG---DVVDDEECNMKLRPN-DIENCDMGPCAKSWF 798
T W C CG G+R V C + +VD+E+C +P I C+ PC W
Sbjct: 922 TSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPCQTRWM 981
Query: 799 LTEWSERCSAECGAGVRTRSVVCMTNHVSSLPL-----EGCGNNRPAEATPCDNGPCTGK 853
+TEW+ CS CG G+++R V C T +S+ L C +PA A C+ C
Sbjct: 982 MTEWTP-CSRTCGKGMQSRQVAC-TQQLSNGTLIRARERDCIGPKPASAQRCEGQDCM-- 1037
Query: 854 VEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPCG 913
W AG WS+CS++CG G + R V C +C +P + C
Sbjct: 1038 TVWEAGVWSECSVKCGKGIRHRTVRCTNPR---------KKCVLSTRPREAEDCEDYSKC 1088
Query: 914 AKWFSTEWSMCSKSCQGGFRVREVRCLSD-DMTLSNLCDPQLKPEERESCNPQDCVPEVD 972
W +WS CS +C G + R ++C+ N C KP C+ Q C +++
Sbjct: 1089 YVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQPCNEKIN 1148
Query: 973 EN-------------CKDKYY--NCNVVVQARLCVYNYYKTACCASC 1004
N C + C V+ + LC + CC +C
Sbjct: 1149 VNTITSPRLAALTFKCLGDQWPVYCRVIREKNLCQDMRWYQRCCETC 1195
Score = 86.7 bits (213), Expect = 1e-16
Identities = 53/171 (30%), Positives = 72/171 (42%), Gaps = 12/171 (7%)
Query: 797 WFLTEWSERCSAECGAGVRTRSVVC---MTNHVSSLPLEGCG--NNRPAEATPCDNGPCT 851
W T W E C A CG G R +V C M+ ++S + E C + C+ PC
Sbjct: 919 WTHTSW-EDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPC- 976
Query: 852 GKVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKP 911
+ W W+ CS CG G Q R+V C ++ ++ + KP S Q C +
Sbjct: 977 -QTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPKPASAQRCEGQD 1035
Query: 912 CGAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERESC 962
C W + WS CS C G R R VRC + C +P E E C
Sbjct: 1036 CMTVWEAGVWSECSVKCGKGIRHRTVRCTNP----RKKCVLSTRPREAEDC 1082
Score = 79.3 bits (194), Expect = 2e-14
Identities = 37/119 (31%), Positives = 58/119 (48%), Gaps = 6/119 (5%)
Query: 856 WFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKP-PSQQSCHLKPCGA 914
W SW C CG G ++ V C + + ++D +C +L KP P + C+ +PC
Sbjct: 919 WTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPCQT 978
Query: 915 KWFSTEWSMCSKSCQGGFRVREVRCLS--DDMTLSNLCDPQL---KPEERESCNPQDCV 968
+W TEW+ CS++C G + R+V C + TL + KP + C QDC+
Sbjct: 979 RWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPKPASAQRCEGQDCM 1037
Score = 36.6 bits (83), Expect = 0.12
Identities = 28/73 (38%), Positives = 31/73 (42%), Gaps = 14/73 (19%)
Query: 57 GAWGPWSACSRSCSGGVMEQTRPC--LPRSYRLRGGQR--------PGAPA--RAFADHV 104
G W WS CSR+CS G+ + R C L R G R P PA F D
Sbjct: 637 GEWSLWSPCSRTCSAGISSRERKCPGLDSEARDCNGPRKQYRICENPPCPAGLPGFRDWQ 696
Query: 105 VSA--VRTSVPLH 115
A VRTS P H
Sbjct: 697 CQAYSVRTSSPKH 709
Score = 35.8 bits (81), Expect = 0.21
Identities = 34/117 (29%), Positives = 45/117 (38%), Gaps = 20/117 (17%)
Query: 756 QRTRDVKCVSNIGDVVDDEECNMKLRPN-DIENCDMGPCAKSWFLT-----------EWS 803
Q + V C V ++EC KL P D +CD+G K+ T EWS
Sbjct: 581 QEMQHVICTGLWCKVEGEKECRTKLDPPMDGTDCDLGKWCKAGECTSRTSAPEHLAGEWS 640
Query: 804 --ERCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNNRP-AEATPCDNGPCTGKVEWF 857
CS C AG+ +R C L E N P + C+N PC + F
Sbjct: 641 LWSPCSRTCSAGISSRERKC-----PGLDSEARDCNGPRKQYRICENPPCPAGLPGF 692
Score = 33.9 bits (76), Expect = 0.80
Identities = 22/72 (30%), Positives = 30/72 (41%), Gaps = 6/72 (8%)
Query: 902 PSQQSCHLKPCGAKWFSTEWSMCSKSCQGGFRVREVRC---LSDDMTL--SNLCDPQLKP 956
P QS W T W C +C GG R V C +S ++++ + C KP
Sbjct: 905 PENQSSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKP 964
Query: 957 EER-ESCNPQDC 967
E + CN Q C
Sbjct: 965 EPQIRKCNEQPC 976
Score = 31.2 bits (69), Expect = 5.2
Identities = 23/77 (29%), Positives = 31/77 (40%), Gaps = 13/77 (16%)
Query: 839 PAEATPCD------NGPCTGKV---EWFAGSWS---QCSIECGSGTQQREVICVRKNADT 886
P + T CD G CT + E AG WS CS C +G RE C +++
Sbjct: 608 PMDGTDCDLGKWCKAGECTSRTSAPEHLAGEWSLWSPCSRTCSAGISSRERKCPGLDSEA 667
Query: 887 FEVLDP-SECSFLEKPP 902
+ P + E PP
Sbjct: 668 RDCNGPRKQYRICENPP 684
>gi|51558724 ADAM metallopeptidase with thrombospondin type 1 motif,
12 preproprotein [Homo sapiens]
Length = 1594
Score = 197 bits (500), Expect = 5e-50
Identities = 142/484 (29%), Positives = 213/484 (44%), Gaps = 55/484 (11%)
Query: 266 SNNHGVGTHGATQSFSQPA-RSTAISCIGAYRQYKLCNTNVCPESSRSIREVQCASYNNK 324
S G G A + + P + C G ++Y+LCN + C + + R++QC+ ++
Sbjct: 555 SRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCRSEAPTFRQMQCSEFDTV 614
Query: 325 PFMGRFYEWEPFAEVKGNRKCELNCQAMGYRFYVRQAEKVIDGTPCDQNGTA--ICVSGQ 382
P+ Y W P CEL C+ + +F + + VIDGTPC + G + +C++G
Sbjct: 615 PYKNELYHWFPIFNPA--HPCELYCRPIDGQFSEKMLDAVIDGTPCFEGGNSRNVCINGI 672
Query: 383 CKSIGCDDYLGSDKVVDKCGVCGGDNTGCQVVSGVFKHALTSLGYHRVVEIPEGATKINI 442
CK +GCD + S+ D+CGVC GD + CQ V +FK S GY + IP+GA I +
Sbjct: 673 CKMVGCDYEIDSNATEDRCGVCLGDGSSCQTVRKMFKQKEGS-GYVDIGLIPKGARDIRV 731
Query: 443 TEMYKSNNYLALRSRS-GRSIINGNWAIDRPGKYEGGGTMFTYKRPNEISSTAGESFLAE 501
E+ + N+LA+RS + +NG + I G Y+ GT+F Y R ++ E +A
Sbjct: 732 MEIEGAGNFLAIRSEDPEKYYLNGGFIIQWNGNYKLAGTVFQYDRKGDL-----EKLMAT 786
Query: 502 GPTNEILDVYMIHQQPNPGVHYEYVIM--GTNAISPQVPPHRRPGEPFNGQMVTEG---- 555
GPTNE + + ++ Q NPG+ YEY I G + Q + G + VT G
Sbjct: 787 GPTNESVWIQLLFQVTNPGIKYEYTIQKDGLDNDVEQQMYFWQYGH-WTECSVTCGTGIR 845
Query: 556 RSQEEGEQKGRNEEKEDLRGEAPEMFTSESAQTFPVRHPDRFSPHRPDNLVPPAPQPPRR 615
R +KG RG F Q P+ PPR
Sbjct: 846 RQTAHCIKKG--------RGMVKATFCDPETQ-----------PNGRQKKCHEKACPPR- 885
Query: 616 SRDHNWKQLGTTECSTTCG-KGSQYPIFRCVHRSTHEE--APESYCDSSMKPTPEEEPCN 672
W CS TCG G + C+ +E P + C +KP
Sbjct: 886 -----WWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNR 940
Query: 673 IFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQ 732
CP+ W +G WSECS +CG G++ R V C + + C KP + + C
Sbjct: 941 DILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKNHDE--------PCDVTRKPNSRALCG 992
Query: 733 LKIC 736
L+ C
Sbjct: 993 LQQC 996
Score = 134 bits (337), Expect = 4e-31
Identities = 83/273 (30%), Positives = 121/273 (44%), Gaps = 34/273 (12%)
Query: 744 DWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCDMGPCAKSWFLTEWS 803
+W+ CS CG+G R V+C + + D +C RP+ + C + PCA W + WS
Sbjct: 1321 NWSECSTTCGLGAYWRRVECSTQM-----DSDCAAIQRPDPAKRCHLRPCA-GWKVGNWS 1374
Query: 804 ERCSAECGAGVRTRSVVCMTN--HVSSLPL--EGCGNNRPAEATPCDNGPCTGKVEWFAG 859
+CS C G + R + C+ + H + P + P + C+ PC W
Sbjct: 1375 -KCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCEA---WQVE 1430
Query: 860 SWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPCGAKWFST 919
WSQCS CG G Q+R V C C + ++P S SC+ C W +
Sbjct: 1431 PWSQCSRSCGGGVQERGVFC-----------PGGLCDWTKRPTSTMSCNEHLC-CHWATG 1478
Query: 920 EWSMCSKSCQGGFRVREVRCLSDDMTLSN-----LCDPQLKPEERESCNPQDCVPEVDEN 974
W +CS SC GGF+ R V+C+ + + LCD + +P E + CN Q C D
Sbjct: 1479 NWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKSADLL 1538
Query: 975 C-KDKYYN--CNVVVQARLCVYNYYKTACCASC 1004
C KDK C + + C + CC SC
Sbjct: 1539 CTKDKLSASFCQTLKAMKKCSVPTVRAECCFSC 1571
Score = 127 bits (320), Expect = 4e-29
Identities = 80/266 (30%), Positives = 116/266 (43%), Gaps = 44/266 (16%)
Query: 678 AFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKICS 737
A W +G WSECS TCGLG R+V C T C +++P+ C L+ C+
Sbjct: 1315 AHWIVGNWSECSTTCGLGAYWRRVECS--------TQMDSDCAAIQRPDPAKRCHLRPCA 1366
Query: 738 EWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIE----------- 786
W++ +W+ CS C G + R+++CV D + LRP +
Sbjct: 1367 GWKVG-NWSKCSRNCSGGFKIREIQCV--------DSRDHRNLRPFHCQFLAGIPPPLSM 1417
Query: 787 NCDMGPCAKSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCG-NNRPAEATPC 845
+C+ PC ++W + WS+ CS CG GV+ R V C P C RP C
Sbjct: 1418 SCNPEPC-EAWQVEPWSQ-CSRSCGGGVQERGVFC--------PGGLCDWTKRPTSTMSC 1467
Query: 846 DNGPCTGKVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQ 905
+ C W G+W CS CG G Q+R V CV + E D C +PP +
Sbjct: 1468 NEHLCC---HWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFK 1524
Query: 906 SCHLKPC--GAKWFSTEWSMCSKSCQ 929
C+ + C A T+ + + CQ
Sbjct: 1525 KCNQQACKKSADLLCTKDKLSASFCQ 1550
Score = 115 bits (289), Expect = 2e-25
Identities = 63/179 (35%), Positives = 86/179 (48%), Gaps = 10/179 (5%)
Query: 621 WKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPCPAFW 680
W+ TECS TCG G + C+ + ++CD +P ++ C+ CP W
Sbjct: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKG-RGMVKATFCDPETQPNGRQKKCHEKACPPRW 886
Query: 681 DIGEWSECSKTCG-LGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKIC--S 737
GEW CS TCG G + R VLC Q + + P CQHL KP+T +C I S
Sbjct: 887 WAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDILCPS 946
Query: 738 EWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCDMGPCAKS 796
+W + +W+ CSV CG G R R V C N DE C++ +PN C + C S
Sbjct: 947 DWTV-GNWSECSVSCGGGVRIRSVTCAKN-----HDEPCDVTRKPNSRALCGLQQCPSS 999
Score = 107 bits (268), Expect = 4e-23
Identities = 70/237 (29%), Positives = 108/237 (45%), Gaps = 32/237 (13%)
Query: 620 NWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPCPAF 679
NW +ECSTTCG G+ + C +S C + +P P + C++ PC A
Sbjct: 1321 NW-----SECSTTCGLGAYWRRVEC------STQMDSDCAAIQRPDPAKR-CHLRPC-AG 1367
Query: 680 WDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLE--KPETTSTCQLKICS 737
W +G WS+CS+ C G + R++ C +R+L +P+ CQ L P + +C + C
Sbjct: 1368 WKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNL--RPFHCQFLAGIPPPLSMSCNPEPCE 1425
Query: 738 EWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCDMGPCAKSW 797
WQ+ W+ CS CG G + R V C + C+ RP +C+ C W
Sbjct: 1426 AWQVE-PWSQCSRSCGGGVQERGVFCPGGL--------CDWTKRPTSTMSCNEHLCC-HW 1475
Query: 798 FLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEG---CGNN-RPAEATPCDNGPC 850
W + CS CG G + R+V C+ + + + C + RP E C+ C
Sbjct: 1476 ATGNW-DLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQAC 1531
Score = 97.4 bits (241), Expect = 6e-20
Identities = 56/175 (32%), Positives = 78/175 (44%), Gaps = 10/175 (5%)
Query: 797 WFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCG-NNRP-AEATPCDNGPCTGKV 854
W W+E CS CG G+R ++ C+ + C +P C C +
Sbjct: 828 WQYGHWTE-CSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPR- 885
Query: 855 EWFAGSWSQCSIECGS-GTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKP-C 912
W+AG W CS CG G ++R V+C++ + L P++C L KP + SC+ C
Sbjct: 886 -WWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDILC 944
Query: 913 GAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERESCNPQDC 967
+ W WS CS SC GG R+R V C + CD KP R C Q C
Sbjct: 945 PSDWTVGNWSECSVSCGGGVRIRSVTCAKNH---DEPCDVTRKPNSRALCGLQQC 996
Score = 93.6 bits (231), Expect = 9e-19
Identities = 57/173 (32%), Positives = 79/173 (45%), Gaps = 14/173 (8%)
Query: 745 WTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIEN-CDMGPCAKSWFLTEWS 803
WT CSV CG G R + C+ +V C+ + +PN + C C W+ EW
Sbjct: 833 WTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPRWWAGEW- 891
Query: 804 ERCSAECGA-GVRTRSVVCMTNHVS---SLPLEGCGNNRPAEATPCDNGPCTGKVEWFAG 859
E CSA CG G + R+V+C+ VS +LP C + + N +W G
Sbjct: 892 EACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDILCPSDWTVG 951
Query: 860 SWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPC 912
+WS+CS+ CG G + R V C KN D C KP S+ C L+ C
Sbjct: 952 NWSECSVSCGGGVRIRSVTCA-KNHD-------EPCDVTRKPNSRALCGLQQC 996
Score = 88.6 bits (218), Expect = 3e-17
Identities = 50/155 (32%), Positives = 70/155 (45%), Gaps = 14/155 (9%)
Query: 679 FWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKICSE 738
FW G W+ECS TCG G++ + C + R + + + C K C
Sbjct: 827 FWQYGHWTECSVTCGTGIRRQTAHC--IKKGRGMVKATFCDPETQPNGRQKKCHEKACPP 884
Query: 739 WQIRTDWTSCSVPCGV-GQRTRDVKCVSNIGDVVDDE------ECNMKLRPNDIENCDMG 791
+W +CS CG G++ R V C+ +V DE +C L+P + +C+
Sbjct: 885 RWWAGEWEACSATCGPHGEKKRTVLCIQT---MVSDEQALPPTDCQHLLKPKTLLSCNRD 941
Query: 792 -PCAKSWFLTEWSERCSAECGAGVRTRSVVCMTNH 825
C W + WSE CS CG GVR RSV C NH
Sbjct: 942 ILCPSDWTVGNWSE-CSVSCGGGVRIRSVTCAKNH 975
Score = 87.4 bits (215), Expect = 6e-17
Identities = 44/122 (36%), Positives = 63/122 (51%), Gaps = 16/122 (13%)
Query: 852 GKVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKP 911
G W G+WS+CS CG G R V C + S+C+ +++P + CHL+P
Sbjct: 1313 GSAHWIVGNWSECSTTCGLGAYWRRVECSTQM--------DSDCAAIQRPDPAKRCHLRP 1364
Query: 912 CGAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNL----CD--PQLKPEERESCNPQ 965
C A W WS CS++C GGF++RE++C+ D NL C + P SCNP+
Sbjct: 1365 C-AGWKVGNWSKCSRNCSGGFKIREIQCV-DSRDHRNLRPFHCQFLAGIPPPLSMSCNPE 1422
Query: 966 DC 967
C
Sbjct: 1423 PC 1424
Score = 44.7 bits (104), Expect = 5e-04
Identities = 16/28 (57%), Positives = 17/28 (60%)
Query: 53 PGVWGAWGPWSACSRSCSGGVMEQTRPC 80
PG WG W PWS CSR+C GV R C
Sbjct: 542 PGGWGRWSPWSHCSRTCGAGVQSAERLC 569
Score = 33.1 bits (74), Expect = 1.4
Identities = 12/16 (75%), Positives = 13/16 (81%)
Query: 61 PWSACSRSCSGGVMEQ 76
PWS CSRSC GGV E+
Sbjct: 1431 PWSQCSRSCGGGVQER 1446
Score = 33.1 bits (74), Expect = 1.4
Identities = 18/55 (32%), Positives = 25/55 (45%), Gaps = 1/55 (1%)
Query: 629 CSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEE-EPCNIFPCPAFWDI 682
CST+CG G Q +CV ++ + C KP P E + CN C D+
Sbjct: 1483 CSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKSADL 1537
Score = 32.3 bits (72), Expect = 2.3
Identities = 12/25 (48%), Positives = 15/25 (60%)
Query: 58 AWGPWSACSRSCSGGVMEQTRPCLP 82
A G W CS SC GG ++T C+P
Sbjct: 1476 ATGNWDLCSTSCGGGFQKRTVQCVP 1500
Score = 32.0 bits (71), Expect = 3.0
Identities = 11/19 (57%), Positives = 14/19 (73%)
Query: 685 WSECSKTCGLGMQHRQVLC 703
WS CS+TCG G+Q + LC
Sbjct: 551 WSHCSRTCGAGVQSAERLC 569
>gi|21265037 ADAM metallopeptidase with thrombospondin type 1 motif, 3
proprotein [Homo sapiens]
Length = 1205
Score = 185 bits (469), Expect = 2e-46
Identities = 146/490 (29%), Positives = 211/490 (43%), Gaps = 53/490 (10%)
Query: 266 SNNHGVGTHGATQSFSQPAR-STAISCIGAYRQYKLCNTNVCPESSRSIREVQCASYNNK 324
S G G T+ + P + C G +Y+LCNT C + R QC N+
Sbjct: 564 SRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEECQKHFEDFRAQQCQQRNSH 623
Query: 325 -PFMGRFYEWEPFAEVKGNRKCELNCQAMGYRFYVRQAEKVIDGTPCD-QNGTAICVSGQ 382
+ + W P+ ++C L CQ+ + V DGT C ++ +ICV G+
Sbjct: 624 FEYQNTKHHWLPYEHPDPKKRCHLYCQSKETGDVAYMKQLVHDGTHCSYKDPYSICVRGE 683
Query: 383 CKSIGCDDYLGSDKVVDKCGVCGGDNTGCQVVSGVFKHALTSLGYHRVVEIPEGATKINI 442
C +GCD +GS+KV DKCGVCGGDN+ C+ V G F LGY ++ +IP GA + I
Sbjct: 684 CVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGYLKMFDIPPGARHVLI 743
Query: 443 TEMYKSNNYLALRSR-SGRSIINGNWAIDRPGKYEGGGTMFTYKRPNEISSTAGESFLAE 501
E S + LA++++ +G I+NG + + G + Y ++I ES +
Sbjct: 744 QEDEASPHILAIKNQATGHYILNGKGEEAKSRTFIDLGVEWDYNIEDDI-----ESLHTD 798
Query: 502 GPTNEILDVYMIHQQ--PNPGVHYEYVIMGTNAISPQVPPHRRPGEPFNGQMVTEGRSQE 559
GP ++ + V +I Q+ + Y+Y+I VP + ++ E
Sbjct: 799 GPLHDPVIVLIIPQENDTRSSLTYKYIIH-----EDSVPTIN------SNNVIQEELDTF 847
Query: 560 EGEQKGRNEEKEDLRGEAPEMFTSESAQTFPVRHPDRFSPHRPDNLVPPAPQPPRRSRDH 619
E K ++ + G +T + R D HR P+P RR +
Sbjct: 848 EWALKSWSQCSKPCGGGF--QYTKYGCR----RKSDNKMVHRSFCEANKKPKPIRRMCNI 901
Query: 620 N------WKQLGTTECSTTCG-KGSQYPIFRCVH---RSTHEEAPESYCDSSMKPTPE-E 668
W C+ TCG G Q RC+ T+ YC M PE
Sbjct: 902 QECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYC---MGDRPESR 958
Query: 669 EPCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETT 728
PCN PCPA W G WSECS TCG G + RQVLCR C EKPE+
Sbjct: 959 RPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLCR----------AGDHCDG-EKPESV 1007
Query: 729 STCQLKICSE 738
CQL C++
Sbjct: 1008 RACQLPPCND 1017
Score = 97.8 bits (242), Expect = 5e-20
Identities = 69/215 (32%), Positives = 96/215 (44%), Gaps = 16/215 (7%)
Query: 797 WFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEG-CGNNRPAEATP--CDNGPCTGK 853
W L WS+ CS CG G + C + + C N+ + C+ CT
Sbjct: 849 WALKSWSQ-CSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHP 907
Query: 854 VEWFAGSWSQCSIECGS-GTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPC 912
+ W A W C+ CGS G Q R V C++ D S+ ++P S++ C+ PC
Sbjct: 908 L-WVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCNRVPC 966
Query: 913 GAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERESCNPQDCVPEVD 972
A+W + WS CS +C G VR+V C + D CD + KPE +C C D
Sbjct: 967 PAQWKTGPWSECSVTCGEGTEVRQVLCRAGDH-----CDGE-KPESVRACQLPPC---ND 1017
Query: 973 ENC-KDKYYNCNVVVQARLCVYNYYKTACCASCTR 1006
E C DK C + V AR C Y CC SC++
Sbjct: 1018 EPCLGDKSIFCQMEVLARYCSIPGYNKLCCESCSK 1052
Score = 97.1 bits (240), Expect = 8e-20
Identities = 61/192 (31%), Positives = 83/192 (43%), Gaps = 12/192 (6%)
Query: 621 WKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPCP-AF 679
W ++CS CG G QY + C +S ++ S+C+++ KP P CNI C
Sbjct: 849 WALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPL 908
Query: 680 WDIGEWSECSKTCG-LGMQHRQVLCRQ-VYANRSLTVQPYRCQHLEKPETTSTCQLKICS 737
W EW C+KTCG G Q R V C Q + + +V C ++PE+ C C
Sbjct: 909 WVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMG-DRPESRRPCNRVPCP 967
Query: 738 EWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCDMGPCAKSW 797
W+ CSV CG G R V C GD D E +P + C + PC
Sbjct: 968 AQWKTGPWSECSVTCGEGTEVRQVLC--RAGDHCDGE------KPESVRACQLPPCNDEP 1019
Query: 798 FLTEWSERCSAE 809
L + S C E
Sbjct: 1020 CLGDKSIFCQME 1031
Score = 89.7 bits (221), Expect = 1e-17
Identities = 59/185 (31%), Positives = 88/185 (47%), Gaps = 27/185 (14%)
Query: 738 EWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGD-VVDDEECNMKLRPNDIEN-CDMGPCAK 795
EW +++ W+ CS PCG G + C + +V C +P I C++ C
Sbjct: 848 EWALKS-WSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTH 906
Query: 796 S-WFLTEWSERCSAECG-AGVRTRSVVCM------TNHVSSLPLEGCGNNRPAEATPCDN 847
W EW E C+ CG +G + R+V C+ TN S+ + C +RP PC+
Sbjct: 907 PLWVAEEW-EHCTKTCGSSGYQLRTVRCLQPLLDGTNR--SVHSKYCMGDRPESRRPCNR 963
Query: 848 GPCTGKVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSC 907
PC +W G WS+CS+ CG GT+ R+V+C + D + EKP S ++C
Sbjct: 964 VPC--PAQWKTGPWSECSVTCGEGTEVRQVLC--RAGDHCDG---------EKPESVRAC 1010
Query: 908 HLKPC 912
L PC
Sbjct: 1011 QLPPC 1015
Score = 36.6 bits (83), Expect = 0.12
Identities = 16/38 (42%), Positives = 22/38 (57%), Gaps = 1/38 (2%)
Query: 54 GVWGAWGPWSACSRSCSGGVMEQTRPCLPRSYRLRGGQ 91
G WG+W + +CSR+C GV +TR C + GGQ
Sbjct: 552 GNWGSWTKFGSCSRTCGTGVRFRTRQC-NNPMPINGGQ 588
>gi|226442878 ADAMTS-like 5 [Homo sapiens]
Length = 471
Score = 184 bits (468), Expect = 3e-46
Identities = 94/237 (39%), Positives = 132/237 (55%), Gaps = 11/237 (4%)
Query: 291 CIGAYRQYKLCNTNVCPESSRSIREVQCASYNNKPFMG--RFYEWEPFAEVKGNRKCELN 348
C G +Y+LC CP + R++QCA YN +P +G + Y+W PF +C+LN
Sbjct: 71 CWGDSHEYRLCQLPDCPPGAVPFRDLQCALYNGRPVLGTQKTYQWVPFHGAPN--QCDLN 128
Query: 349 CQAMGYRFYVRQAEKVIDGTPCDQNGTAICVSGQCKSIGCDDYLGSDKVVDKCGVCGGDN 408
C A G+ FY +V+DGT C +CV+G+C S GCD LGS + D+CG CGG N
Sbjct: 129 CLAEGHAFY-HSFGRVLDGTACSPGAQGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGAN 187
Query: 409 TGCQVVSGVFKHALTSLGYHRVVEIPEGATKINITEMYKSNNYLALRSRSGRSIINGNWA 468
C V VF+ A GY V IPEGA I + ++S N+LAL GR ++NG+W
Sbjct: 188 DSCLFVQRVFRDAGAFAGYWNVTLIPEGARHIRVE--HRSRNHLALMGGDGRYVLNGHWV 245
Query: 469 IDRPGKYEGGGTMFTYKRPNEISSTAGESFLAEGPTNEILDVYMIHQQPNPGVHYEY 525
+ PG YE GT Y R + E+ A GPT+ L + ++ Q+PNPG+ +E+
Sbjct: 246 VSPPGTYEAAGTHVVYTR----DTGPQETLQAAGPTSHDLLLQVLLQEPNPGIEFEF 298
Score = 37.4 bits (85), Expect = 0.072
Identities = 14/29 (48%), Positives = 17/29 (58%)
Query: 53 PGVWGAWGPWSACSRSCSGGVMEQTRPCL 81
PG W W W+ CS SC GV ++R CL
Sbjct: 35 PGEWTPWVSWTRCSSSCGRGVSVRSRRCL 63
>gi|110611170 ADAM metallopeptidase with thrombospondin type 1 motif,
17 preproprotein [Homo sapiens]
Length = 1095
Score = 181 bits (459), Expect = 3e-45
Identities = 145/510 (28%), Positives = 209/510 (40%), Gaps = 70/510 (13%)
Query: 291 CIGAYRQYKLCNTNVCPESSRSIREVQCASYNNKPFMGRFYEWEPFAEVKGNRKCELNCQ 350
C GA ++ +C CP+ S R+ QC +++ + + A V ++ CEL C
Sbjct: 582 CPGASVEHAVCENLPCPKGLPSFRDQQCQAHDR---LSPKKKGLLTAVVVDDKPCELYCS 638
Query: 351 AMGYRFYVRQAEKVIDGTPCDQNGTAICVSGQCKSIGCDDYLGSDKVVDKCGVCGGDNTG 410
+G + A++V+DGTPC T +CV G+C+ IGCD +GS D+CGVC GD
Sbjct: 639 PLGKESPLLVADRVLDGTPCGPYETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKT 698
Query: 411 CQVVSGVFKHALTSLGYHRVVEIPEGATKINITEMYKSNNYLALRSRSGRSIINGNWAID 470
C +V G F HA + AL+ SG+ IN +W I+
Sbjct: 699 CHLVKGDFSHARGT----------------------------ALKD-SGKGSINSDWKIE 729
Query: 471 RPGKYEGGGTMFTYKRPNEISSTAGESFLAEGPTNEILD--VYMIHQQPNPGVHYEYVIM 528
PG+++ GT Y R E A+GPT L V + H Q + G+HYEY +
Sbjct: 730 LPGEFQIAGTTVRYVRRG-----LWEKISAKGPTKLPLHLMVLLFHDQ-DYGIHYEYTVP 783
Query: 529 GTNAISPQVPPHRRPGEPFNGQMVTEGRSQEEGEQKGRNEEKEDLRGEAPEMFTSESAQT 588
Q P + F + T + Q G E R + T
Sbjct: 784 VNRTAENQSEPEKPQDSLF---IWTHSGWEGCSVQCGGGE-----RRTIVSCTRIVNKTT 835
Query: 589 FPVRHPDRFSPHRPDNLVPPAPQPPRRSRDHNWKQLGTTECSTTCGKGSQYPIFRCVHR- 647
V D RP+ V P +SR W + CS TC KG Q+ CV++
Sbjct: 836 TLVNDSDCPQASRPEPQVRRCNLHPCQSR---WVAGPWSPCSATCEKGFQHREVTCVYQL 892
Query: 648 --STHEEAPESYCDSSMKPTPEE-EPCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCR 704
TH YC P P + C C + W+ EWS+CS +CG G+ R V C
Sbjct: 893 QNGTHVATRPLYCPG---PRPAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVAC- 948
Query: 705 QVYANRSLTVQPYRCQHLEKPETTSTCQ-LKICSEWQIRTDWTSCSVPCGVGQRTRDVKC 763
T +C +P C+ C EW+ DW++CS CG G ++R V+C
Sbjct: 949 --------TNSQGKCDASTRPRAEEACEDYSGCYEWK-TGDWSTCSSTCGKGLQSRVVQC 999
Query: 764 VSNIGDVVDDEECNMKLRPNDIENCDMGPC 793
+ + EC +P C C
Sbjct: 1000 MHKVTG-RHGSECPALSKPAPYRQCYQEVC 1028
Score = 124 bits (311), Expect = 5e-28
Identities = 80/285 (28%), Positives = 118/285 (41%), Gaps = 38/285 (13%)
Query: 745 WTSCSVPCGVGQRTRDVKC---VSNIGDVVDDEECNMKLRPN-DIENCDMGPCAKSWFLT 800
W CSV CG G+R V C V+ +V+D +C RP + C++ PC W
Sbjct: 809 WEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQSRWVAG 868
Query: 801 EWSERCSAECGAGVRTRSVVCMTN-----HVSSLPLEGCGNNRPAEATPCDNGPCTGKVE 855
WS CSA C G + R V C+ HV++ PL C RPA C+ C
Sbjct: 869 PWSP-CSATCEKGFQHREVTCVYQLQNGTHVATRPLY-CPGPRPAAVQSCEGQDCLSI-- 924
Query: 856 WFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPCGAK 915
W A WSQCS CG G +R V C +C +P ++++C +
Sbjct: 925 WEASEWSQCSASCGKGVWKRTVACTNSQG---------KCDASTRPRAEEACEDYSGCYE 975
Query: 916 WFSTEWSMCSKSCQGGFRVREVRCLSD-DMTLSNLCDPQLKPEERESCNPQDCVPEVDEN 974
W + +WS CS +C G + R V+C+ + C KP C + C ++ N
Sbjct: 976 WKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVCNDRINAN 1035
Query: 975 --------------CKDKY-YNCNVVVQARLCVYNYYKTACCASC 1004
+D++ C V+ + LC + CC +C
Sbjct: 1036 TITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTC 1080
Score = 121 bits (303), Expect = 4e-27
Identities = 70/237 (29%), Positives = 102/237 (43%), Gaps = 11/237 (4%)
Query: 621 WKQLGTTECSTTCGKGSQYPIFRCVH--RSTHEEAPESYCDSSMKPTPEEEPCNIFPCPA 678
W G CS CG G + I C T +S C + +P P+ CN+ PC +
Sbjct: 804 WTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQS 863
Query: 679 FWDIGEWSECSKTCGLGMQHRQVLC-RQVYANRSLTVQPYRCQHLEKPETTSTCQLKICS 737
W G WS CS TC G QHR+V C Q+ + +P C +P +C+ + C
Sbjct: 864 RWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPG-PRPAAVQSCEGQDCL 922
Query: 738 EWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCDMGPCAKSW 797
++W+ CS CG G R V C ++ G +C+ RP E C+ W
Sbjct: 923 SIWEASEWSQCSASCGKGVWKRTVACTNSQG------KCDASTRPRAEEACEDYSGCYEW 976
Query: 798 FLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNNRPAEATPCDNGPCTGKV 854
+WS CS+ CG G+++R V CM E ++PA C C ++
Sbjct: 977 KTGDWS-TCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVCNDRI 1032
Score = 113 bits (283), Expect = 8e-25
Identities = 75/251 (29%), Positives = 105/251 (41%), Gaps = 20/251 (7%)
Query: 666 PEEEPCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKP 725
PE+ ++F W W CS CG G + V C ++ + V C +P
Sbjct: 794 PEKPQDSLF----IWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRP 849
Query: 726 ET-TSTCQLKICSEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKL---R 781
E C L C + W+ CS C G + R+V CV + + + R
Sbjct: 850 EPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPR 909
Query: 782 PNDIENCDMGPCAKSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNNRPAE 841
P +++C+ C W +EWS+ CSA CG GV R+V C TN + RP
Sbjct: 910 PAAVQSCEGQDCLSIWEASEWSQ-CSASCGKGVWKRTVAC-TNSQGKCD----ASTRPRA 963
Query: 842 ATPCDNGPCTGKVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKP 901
C++ +G EW G WS CS CG G Q R V C+ K SEC L KP
Sbjct: 964 EEACED--YSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGR----HGSECPALSKP 1017
Query: 902 PSQQSCHLKPC 912
+ C+ + C
Sbjct: 1018 APYRQCYQEVC 1028
Score = 87.8 bits (216), Expect = 5e-17
Identities = 58/173 (33%), Positives = 79/173 (45%), Gaps = 16/173 (9%)
Query: 797 WFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNNRPAEATP------CDNGPC 850
W + W E CS +CG G R R++V T V+ ++ P + P C+ PC
Sbjct: 804 WTHSGW-EGCSVQCGGGER-RTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPC 861
Query: 851 TGKVEWFAGSWSQCSIECGSGTQQREVICVRKNAD-TFEVLDPSECSFLEKPPSQQSCHL 909
+ W AG WS CS C G Q REV CV + + T P C +P + QSC
Sbjct: 862 QSR--WVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPG-PRPAAVQSCEG 918
Query: 910 KPCGAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERESC 962
+ C + W ++EWS CS SC G R V C + CD +P E+C
Sbjct: 919 QDCLSIWEASEWSQCSASCGKGVWKRTVACTNS----QGKCDASTRPRAEEAC 967
Score = 83.2 bits (204), Expect = 1e-15
Identities = 44/138 (31%), Positives = 66/138 (47%), Gaps = 6/138 (4%)
Query: 837 NRPAEATPCDNGPCTGKVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECS 896
NR AE P W W CS++CG G ++ V C R T +++ S+C
Sbjct: 785 NRTAENQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCP 844
Query: 897 FLEKP-PSQQSCHLKPCGAKWFSTEWSMCSKSCQGGFRVREVRCL-----SDDMTLSNLC 950
+P P + C+L PC ++W + WS CS +C+ GF+ REV C+ + L
Sbjct: 845 QASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLY 904
Query: 951 DPQLKPEERESCNPQDCV 968
P +P +SC QDC+
Sbjct: 905 CPGPRPAAVQSCEGQDCL 922
Score = 42.0 bits (97), Expect = 0.003
Identities = 21/58 (36%), Positives = 30/58 (51%), Gaps = 6/58 (10%)
Query: 619 HNWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTP----EEEPCN 672
+ WK + CS+TCGKG Q + +C+H+ T E C + KP P +E CN
Sbjct: 974 YEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSE--CPALSKPAPYRQCYQEVCN 1029
Score = 37.0 bits (84), Expect = 0.095
Identities = 13/27 (48%), Positives = 15/27 (55%)
Query: 54 GVWGAWGPWSACSRSCSGGVMEQTRPC 80
G W WG WS CSR+C G + R C
Sbjct: 544 GDWSPWGAWSMCSRTCGTGARFRQRKC 570
Score = 32.0 bits (71), Expect = 3.0
Identities = 33/118 (27%), Positives = 43/118 (36%), Gaps = 31/118 (26%)
Query: 773 DEECNMKLRPNDI--ENCDMGPCAKSWFLTEWSERCSA---------ECGAGVRTRSVVC 821
+E+C + N N + CA W L E C ECGA R+ C
Sbjct: 473 NEQCQILFGMNATFCRNMEHLMCAGLWCLVEGDTSCKTKLDPPLDGTECGADKWCRAGEC 532
Query: 822 MTNHVSSLPLEGCGNNRPAEATPCDNGPCTGKVEWFAGSWSQCSIECGSGTQQREVIC 879
VS P+ E D P W G+WS CS CG+G + R+ C
Sbjct: 533 ----VSKTPIP--------EHVDGDWSP------W--GAWSMCSRTCGTGARFRQRKC 570
Score = 32.0 bits (71), Expect = 3.0
Identities = 12/21 (57%), Positives = 14/21 (66%)
Query: 683 GEWSECSKTCGLGMQHRQVLC 703
G WS CS+TCG G + RQ C
Sbjct: 550 GAWSMCSRTCGTGARFRQRKC 570
>gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens]
Length = 1762
Score = 179 bits (455), Expect = 9e-45
Identities = 118/437 (27%), Positives = 187/437 (42%), Gaps = 91/437 (20%)
Query: 619 HNWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYC---DSSMKPTPEEEPCNIFP 675
H W++ CS TCG G Q C ++ + YC ++KP P+ + CN+ P
Sbjct: 299 HRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDP 358
Query: 676 CPAF-----------------WDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLT-VQPY 717
CPA W+ W+ CS +CG G+Q R V C + +T V+ +
Sbjct: 359 CPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEW 418
Query: 718 RCQHLEKPETTSTCQLKICSEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECN 777
+C + K C + C +W + +W+ C+V CG G R R V C+ + G + C+
Sbjct: 419 KCMYTPKMPIAQPCNIFDCPKW-LAQEWSPCTVTCGQGLRYRVVLCIDHRG--MHTGGCS 475
Query: 778 MKLRPNDIENCDM-GPCAK-----------SW------------------FLTEWSERCS 807
K +P+ E C + PC K W F+ E C+
Sbjct: 476 PKTKPHIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACT 535
Query: 808 AECGAGVRTRSVVC-----MTNHVSSLPLEGCGNNRPAEATPCDNGPCTGKV-------- 854
CG G + R V C + V+ LP++ C +PA C GPC+G++
Sbjct: 536 VTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIPEFNPDET 595
Query: 855 --------------EWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEK 900
+W +++CS CG G Q+ V C+ N T E + + C +
Sbjct: 596 DGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCL--NKQTREPAEENLCVTSRR 653
Query: 901 PPS-QQSCHLKPCGAKWFSTEWSMCSKSCQGGFRVREVRC-------LSDDMTLSNLCDP 952
PP +SC+L PC A+W +WS CS +C G + R+V C +++ + L++
Sbjct: 654 PPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCR 713
Query: 953 QLKPEERESCNPQDCVP 969
Q KP ++CN +C P
Sbjct: 714 QPKPSTVQACNRFNCPP 730
Score = 145 bits (366), Expect = 2e-34
Identities = 117/417 (28%), Positives = 164/417 (39%), Gaps = 81/417 (19%)
Query: 608 PAPQPPRRSRDHNWKQLGTTECSTTCGKGSQYPIFRCV-HRSTHEEAPESYCDSSMKPTP 666
P QP W + C+ TCG+G +Y + C+ HR H C KP
Sbjct: 427 PIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGG----CSPKTKPHI 482
Query: 667 EEEPCNIFPC-------------PAFWDIGE-----------------WSECSKTCGLGM 696
+EE PC P F E WS C+ TCG+G
Sbjct: 483 KEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGT 542
Query: 697 QHRQVLCRQVYANRSLTVQPYRCQHLE--KPETTSTCQLKICS----------------- 737
Q R V C QV + S +V E KP + C CS
Sbjct: 543 QVRIVRC-QVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIPEFNPDETDGLFGG 601
Query: 738 --EWQIRTDW-----TSCSVPCGVGQRTRDVKCVSN-IGDVVDDEECNMKLRPNDI-ENC 788
++ DW T CS CG G + V C++ + ++ C RP + ++C
Sbjct: 602 LQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSC 661
Query: 789 DMGPCAKSWFLTEWSERCSAECGAGVRTRSVVCM------TNHVSSLPLEGCGNNRPAEA 842
++ PC W + +WS CS CG G++TR V C N L E C +P+
Sbjct: 662 NLDPCPARWEIGKWSP-CSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTV 720
Query: 843 TPCDNGPCTGKVEWFAGSWSQCSIECGSGTQQREVICVRKNAD-TFEVLDPSECSFLEKP 901
C+ C W+ W CS CG G Q+REV+C ++ AD +F L + CS KP
Sbjct: 721 QACNRFNCPPA--WYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCS-ASKP 777
Query: 902 PSQQSCHLKPCGAKWFSTEWSMCSKSCQGGFRVREVRCLS------DDMTLSNLCDP 952
QQ+C C ++W ++W+ CS SC G + R C + S LC P
Sbjct: 778 ACQQACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPP 834
Score = 124 bits (310), Expect = 6e-28
Identities = 80/273 (29%), Positives = 123/273 (45%), Gaps = 26/273 (9%)
Query: 747 SCSVPCGV-GQRTRDVKCVSNIGDVVDDEECNMKLRPN-DIENCDMGPCAKSWFLTEWSE 804
+CS CG G + ++C+ N +V + C K+RP C+ C W +T WS
Sbjct: 1498 TCSASCGNRGVQQPRLRCLLNSTEV-NPAHCAGKVRPAVQPIACNRRDCPSRWMVTSWSA 1556
Query: 805 RCSAECGAGVRTRSVVCMTNHVSSLPLEGCGN------NRPAEATPCDNGPCTGKVEWFA 858
C+ CG GV+TR V C S + + RP + C+ C VEW
Sbjct: 1557 -CTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLC---VEWAF 1612
Query: 859 GSWSQCSIECGS---GTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPCGAK 915
SW QC+ C Q R+V C ++ T L +CS L +P S Q+C + C
Sbjct: 1613 SSWGQCNGPCIGPHLAVQHRQVFCQTRDGIT---LPSEQCSALPRPVSTQNCWSEACSVH 1669
Query: 916 WFSTEWSMCSKSCQG-GFRVREVRCL---SDDMTLSNLCDPQLKPEERESCNPQDCVPEV 971
W + W++C+ +C GF+ R V C+ ++ +LC +P + CN C
Sbjct: 1670 WRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNITPC---E 1726
Query: 972 DENCKDKYYNCNVVVQARLCVYNYYKTACCASC 1004
+ C+D C V Q +LC + +K+ CC +C
Sbjct: 1727 NMECRDTTRYCEKVKQLKLCQLSQFKSRCCGTC 1759
Score = 121 bits (304), Expect = 3e-27
Identities = 67/188 (35%), Positives = 96/188 (51%), Gaps = 2/188 (1%)
Query: 273 THGATQSFSQPARSTAISCIGAYRQYKLCNTNVCPESSRSIREVQCASYNNKPFMGRFYE 332
T G S+S ++ SC G +Y+ C+ CP + R QC+++N+ G+FYE
Sbjct: 48 TCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYE 107
Query: 333 WEPFAEVKGNRKCELNCQAMGYRFYVRQAEKVIDGTPCDQNGTAICVSGQCKSIGCDDYL 392
W P + N C L CQA G V A KV+DGT C +C+SG C+ +GCD L
Sbjct: 108 WLPVSNDPDN-PCSLKCQAKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQL 166
Query: 393 GSDKVVDKCGVCGGDNTGCQVVSGVFKHALTSL-GYHRVVEIPEGATKINITEMYKSNNY 451
GS D CGVC GD + C++V G +K L++ VV IP G+ I + + Y
Sbjct: 167 GSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLY 226
Query: 452 LALRSRSG 459
L ++ G
Sbjct: 227 LETKTLQG 234
Score = 120 bits (302), Expect = 5e-27
Identities = 77/248 (31%), Positives = 123/248 (49%), Gaps = 18/248 (7%)
Query: 617 RDHNWKQLGTTECSTTCG-KGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFP 675
+D+ W CS +CG +G Q P RC+ ST E ++C ++P + CN
Sbjct: 1487 QDYWWSVDRLATCSASCGNRGVQQPRLRCLLNST--EVNPAHCAGKVRPAVQPIACNRRD 1544
Query: 676 CPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANR-SLTVQPYRC-QHLEKPETTSTCQL 733
CP+ W + WS C+++CG G+Q R+V C+++ A+ S V C Q ++P T C
Sbjct: 1545 CPSRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQ 1604
Query: 734 KICSEWQIRTDWTSCSVPC---GVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCDM 790
++C EW + W C+ PC + + R V C + G + E+C+ RP +NC
Sbjct: 1605 QLCVEWAF-SSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWS 1663
Query: 791 GPCAKSWFLTEWSERCSAECG-AGVRTRSVVCMTNHVS-SLPLEGCG-NNRPA-----EA 842
C+ W ++ W+ C+A CG G ++R V C+ + ++P C RPA
Sbjct: 1664 EACSVHWRVSLWT-LCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNI 1722
Query: 843 TPCDNGPC 850
TPC+N C
Sbjct: 1723 TPCENMEC 1730
Score = 82.4 bits (202), Expect = 2e-15
Identities = 53/193 (27%), Positives = 77/193 (39%), Gaps = 24/193 (12%)
Query: 792 PCAKSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNNRPAEATP------C 845
P W T++ CSA CG G + S C + + + + P P C
Sbjct: 296 PIIHRWRETDFFP-CSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQEC 354
Query: 846 DNGPCTGK---------------VEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEV- 889
+ PC W A W+ CS CG G Q R V CV ++
Sbjct: 355 NLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTS 414
Query: 890 LDPSECSFLEKPPSQQSCHLKPCGAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNL 949
++ +C + K P Q C++ C KW + EWS C+ +C G R R V C+ +
Sbjct: 415 VEEWKCMYTPKMPIAQPCNIFDC-PKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGG 473
Query: 950 CDPQLKPEERESC 962
C P+ KP +E C
Sbjct: 474 CSPKTKPHIKEEC 486
Score = 64.3 bits (155), Expect = 6e-10
Identities = 34/122 (27%), Positives = 60/122 (49%), Gaps = 13/122 (10%)
Query: 856 WFAGSWSQCSIECGS-GTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQ-SCHLKPCG 913
W + CS CG+ G QQ + C+ + + ++P+ C+ +P Q +C+ + C
Sbjct: 1491 WSVDRLATCSASCGNRGVQQPRLRCLLNSTE----VNPAHCAGKVRPAVQPIACNRRDCP 1546
Query: 914 AKWFSTEWSMCSKSCQGGFRVREVRC-------LSDDMTLSNLCDPQLKPEERESCNPQD 966
++W T WS C++SC GG + R V C +S ++ +P + ++CN Q
Sbjct: 1547 SRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQL 1606
Query: 967 CV 968
CV
Sbjct: 1607 CV 1608
Score = 47.4 bits (111), Expect = 7e-05
Identities = 17/28 (60%), Positives = 19/28 (67%)
Query: 54 GVWGAWGPWSACSRSCSGGVMEQTRPCL 81
G+W AWGPWS CSR+C GG R CL
Sbjct: 34 GLWDAWGPWSECSRTCGGGASYSLRRCL 61
Score = 35.0 bits (79), Expect = 0.36
Identities = 17/59 (28%), Positives = 27/59 (45%), Gaps = 1/59 (1%)
Query: 680 WDI-GEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKICS 737
WD G WSECS+TCG G + C + ++ C +++ P + + CS
Sbjct: 36 WDAWGPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCS 94
Score = 32.3 bits (72), Expect = 2.3
Identities = 19/53 (35%), Positives = 24/53 (45%), Gaps = 1/53 (1%)
Query: 617 RDHNWKQLGT-TECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEE 668
RD W G +ECS TCG G+ Y + RC+ + E Y S P E
Sbjct: 32 RDGLWDAWGPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPE 84
Score = 31.6 bits (70), Expect = 4.0
Identities = 10/21 (47%), Positives = 14/21 (66%)
Query: 61 PWSACSRSCSGGVMEQTRPCL 81
PW+ACS SC GG+ + C+
Sbjct: 384 PWTACSSSCGGGIQSRAVSCV 404
Score = 31.2 bits (69), Expect = 5.2
Identities = 30/118 (25%), Positives = 44/118 (37%), Gaps = 26/118 (22%)
Query: 859 GSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPCGA---- 914
G WS+CS CG G C+ + + CS ++ PP + C A
Sbjct: 40 GPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDV 99
Query: 915 -------KWF---STEWSMCSKSCQ--GGFRVREV--------RCLSD--DMTLSNLC 950
+W + + CS CQ G V E+ RC ++ DM +S LC
Sbjct: 100 KHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVVELAPKVLDGTRCYTESLDMCISGLC 157
Score = 31.2 bits (69), Expect = 5.2
Identities = 18/53 (33%), Positives = 25/53 (47%), Gaps = 7/53 (13%)
Query: 921 WSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERESCNPQDCVPEVDE 973
WS CS++C GG RCLS S C+ + +C+ DC PE +
Sbjct: 42 WSECSRTCGGGASYSLRRCLS-----SKSCEG--RNIRYRTCSNVDCPPEAGD 87
Score = 30.4 bits (67), Expect = 8.9
Identities = 11/19 (57%), Positives = 13/19 (68%)
Query: 62 WSACSRSCSGGVMEQTRPC 80
WSAC+RSC GGV + C
Sbjct: 1554 WSACTRSCGGGVQTRRVTC 1572
>gi|21265058 a disintegrin-like and metalloprotease (reprolysin
type) with thrombospondin type 1 motif, 15 preproprotein
[Homo sapiens]
Length = 950
Score = 179 bits (453), Expect = 2e-44
Identities = 138/461 (29%), Positives = 207/461 (44%), Gaps = 80/461 (17%)
Query: 291 CIGAYRQYKLCNTNVCPESS--RSIREVQCASYNNKPF----MGRFYEWEP-FAEVKGNR 343
C G +Y+ CN CP S+ +S RE QC ++N + W P ++ V
Sbjct: 555 CEGVRVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRD 614
Query: 344 KCELNCQAMGYRFYVRQAEKVIDGTPCDQNGTAICVSGQCKSIGCDDYLGSDKVVDKCGV 403
KC+L C+A G ++ A KV+DGT C + T++CV G+C GCD LGS K DKCGV
Sbjct: 615 KCKLICRANGTGYFYVLAPKVVDGTLCSPDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGV 674
Query: 404 CGGDNTGCQVVSGVFKHALTSLGYHRVVEIPEGATKINITEM-YK----SNNYLALRSRS 458
CGGDN C+ V+G+F + GY+ VV IP GA+ I+I + YK +NYLAL++
Sbjct: 675 CGGDNKSCKKVTGLFTKPMH--GYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQ 732
Query: 459 GRSIINGNWAIDRPGK-YEGGGTMFTYKRPNEISSTAGESFLAEGPTNEIL--DVYMIHQ 515
G+ ++NG++ + + G++ Y + TA ES A P E L +V + +
Sbjct: 733 GKYLLNGHFVVSAVERDLVVKGSLLRYSG----TGTAVESLQASRPILEPLTVEVLSVGK 788
Query: 516 QPNPGVHYEYVIMGTNAISPQVPPHRRPGEPFNGQMVTEGRSQEEGEQKGRNEEKEDLRG 575
P V Y + + P EP ++ ++ +D RG
Sbjct: 789 MTPPRVRYSFYL---------------PKEP----------------REDKSSHPKDPRG 817
Query: 576 EAPEMFTSESAQTFPVRHPDRFSPHRPDNLVPPAPQPPRRSRDHNWKQLGTTECSTTCGK 635
+ + S + + V PD +PP R W CS +CG
Sbjct: 818 PS-VLHNSVLSLSNQVEQPD--------------DRPPAR-----WVAGSWGPCSASCGS 857
Query: 636 GSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPCPAFWDIGEWSECSKTCGLG 695
G Q C + P CD++ +P E + C PCP W++ WS CSK+CG G
Sbjct: 858 GLQKRAVDCRGSAGQRTVPA--CDAAHRPV-ETQACG-EPCPT-WELSAWSPCSKSCGRG 912
Query: 696 MQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKIC 736
Q R + C + + +C KP+ C L+ C
Sbjct: 913 FQRRSLKC---VGHGGRLLARDQCNLHRKPQELDFCVLRPC 950
Score = 83.2 bits (204), Expect = 1e-15
Identities = 42/134 (31%), Positives = 67/134 (50%), Gaps = 12/134 (8%)
Query: 660 SSMKPTPEEEPCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRC 719
S+ P++ P PA W G W CS +CG G+Q R V CR R++ C
Sbjct: 829 SNQVEQPDDRP------PARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPA----C 878
Query: 720 QHLEKPETTSTCQLKICSEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMK 779
+P T C + C W++ W+ CS CG G + R +KCV + G ++ ++CN+
Sbjct: 879 DAAHRPVETQACG-EPCPTWELSA-WSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLH 936
Query: 780 LRPNDIENCDMGPC 793
+P +++ C + PC
Sbjct: 937 RKPQELDFCVLRPC 950
Score = 72.0 bits (175), Expect = 3e-12
Identities = 42/114 (36%), Positives = 58/114 (50%), Gaps = 8/114 (7%)
Query: 856 WFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPCGAK 915
W AGSW CS CGSG Q+R V C R +A V C +P Q+C +PC
Sbjct: 843 WVAGSWGPCSASCGSGLQKRAVDC-RGSAGQRTV---PACDAAHRPVETQACG-EPC-PT 896
Query: 916 WFSTEWSMCSKSCQGGFRVREVRCLSDD--MTLSNLCDPQLKPEERESCNPQDC 967
W + WS CSKSC GF+ R ++C+ + + C+ KP+E + C + C
Sbjct: 897 WELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC 950
Score = 66.6 bits (161), Expect = 1e-10
Identities = 43/131 (32%), Positives = 58/131 (44%), Gaps = 11/131 (8%)
Query: 783 NDIENCDMGPCAKSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGC-GNNRPAE 841
N +E D P A+ W W CSA CG+G++ R+V C + C +RP E
Sbjct: 830 NQVEQPDDRPPAR-WVAGSWGP-CSASCGSGLQKRAVDC-RGSAGQRTVPACDAAHRPVE 886
Query: 842 ATPCDNGPCTGKVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKP 901
C PC W +WS CS CG G Q+R + CV +L +C+ KP
Sbjct: 887 TQACGE-PCP---TWELSAWSPCSKSCGRGFQRRSLKCVGHGG---RLLARDQCNLHRKP 939
Query: 902 PSQQSCHLKPC 912
C L+PC
Sbjct: 940 QELDFCVLRPC 950
Score = 37.0 bits (84), Expect = 0.095
Identities = 13/27 (48%), Positives = 15/27 (55%)
Query: 54 GVWGAWGPWSACSRSCSGGVMEQTRPC 80
G W W P+ CSR+C GGV R C
Sbjct: 517 GSWAKWDPYGPCSRTCGGGVQLARRQC 543
Score = 35.4 bits (80), Expect = 0.28
Identities = 17/50 (34%), Positives = 23/50 (46%), Gaps = 1/50 (2%)
Query: 914 AKWFSTEWSMCSKSCQGGFRVREVRCL-SDDMTLSNLCDPQLKPEERESC 962
A+W + W CS SC G + R V C S CD +P E ++C
Sbjct: 841 ARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQAC 890
>gi|145275198 ADAMTS-like 3 precursor [Homo sapiens]
Length = 1691
Score = 176 bits (447), Expect = 8e-44
Identities = 118/427 (27%), Positives = 182/427 (42%), Gaps = 82/427 (19%)
Query: 619 HNWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYC---DSSMKPTPEEEPCNIFP 675
H W+Q C+ TCG G Q CV P+ YC ++KP P+ + C++ P
Sbjct: 341 HQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDP 400
Query: 676 CPAF-----------------WDIGEWSECSKTCGLGMQHRQVLC-RQVYANRSLTVQPY 717
CP+ W+ W+ CS +CG G+Q R +C + L V+ +
Sbjct: 401 CPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEW 460
Query: 718 RCQHLEKPETTSTCQLKICSEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECN 777
+C + KP+ TC L C +W I +W+ C+V CG G R R V C+++ G+ V CN
Sbjct: 461 KCMYAPKPKVMQTCNLFDCPKW-IAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGG--CN 517
Query: 778 MKLRPNDIENCDMG-PCAK-----------SW------------------FLTEWSERCS 807
+L+ + E C + PC K W F+ E CS
Sbjct: 518 PQLKLHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACS 577
Query: 808 AECGAGVRTRSVVC-----MTNHVSSLPLEGC-----GNNRPAEATPCDNGPCTGKV--- 854
CG GV+ R V C T + LP E C RP CD P + ++
Sbjct: 578 TTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEACDESPASRELDIP 637
Query: 855 ---------EWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPS-Q 904
+W ++ C+ C G Q+ +C+ + T + ++ S C + +PP+
Sbjct: 638 LPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCL--HIQTQQTVNDSLCDMVHRPPAMS 695
Query: 905 QSCHLKPCGAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLS--NLCDPQLKPEERESC 962
Q+C+ +PC +W W CS +C G + R+V CL T + C + KP ++C
Sbjct: 696 QACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDE-KPHALQAC 754
Query: 963 NPQDCVP 969
N DC P
Sbjct: 755 NQFDCPP 761
Score = 161 bits (407), Expect = 3e-39
Identities = 138/475 (29%), Positives = 191/475 (40%), Gaps = 87/475 (18%)
Query: 594 PDRFSPHRPDNLVP----------PAPQPPRRSR----DH-----NWKQLGTTECSTTCG 634
PD + + P+N+ P P P DH W+ T CS +CG
Sbjct: 376 PDHYCHYYPENVKPKPKLKECSMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCG 435
Query: 635 KGSQYPIFRCVHRSTHEE---APESYCDSSMKPTPEEEPCNIFPCPAFWDIGEWSECSKT 691
G Q F CV S H E E C + KP + CN+F CP W EWS+C+ T
Sbjct: 436 GGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVMQT-CNLFDCPK-WIAMEWSQCTVT 493
Query: 692 CGLGMQHRQVLCRQVYANRSLTVQPYRCQHLE----------KPETTSTCQLKI------ 735
CG G+++R VLC P H++ KP+ S + K+
Sbjct: 494 CGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKSPVEAKLPWLKQA 553
Query: 736 --CSEWQIRTD--------WTSCSVPCGVGQRTRDVKC-----VSNIGDVVDDEECNMKL 780
E +I T+ W++CS CG G + R+VKC + + +EEC
Sbjct: 554 QELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPK 613
Query: 781 RPND----IENCDMGPCAKSWF--LTEWSER-----------CSAECGAGVRTRSVVCM- 822
P + +E CD P ++ L E SE C+A C G + VC+
Sbjct: 614 LPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLH 673
Query: 823 --TNHVSSLPLEGCGNNRPAEATPCDNGPCTGKVEWFAGSWSQCSIECGSGTQQREVICV 880
T + L + PA + C+ PC + W GSW CS CG G Q R+V C+
Sbjct: 674 IQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPR--WHVGSWGPCSATCGVGIQTRDVYCL 731
Query: 881 RKNADTFEVLDPSECSFLEKPPSQQSCHLKPCGAKWFSTEWSMCSKSCQGGFRVREVRC- 939
P EC EKP + Q+C+ C W EW CS++C GG + R V C
Sbjct: 732 HPGETP---APPEECRD-EKPHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCR 787
Query: 940 -LSDDMTLSNLCDPQL---KPEERESCNPQDCVPEVDENCKDK-YYNCNVVVQAR 989
L D + NL D K +SC DC P + K +C V +Q R
Sbjct: 788 QLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPHLAVGDWSKCSVSCGVGIQRR 842
Score = 131 bits (330), Expect = 3e-30
Identities = 106/376 (28%), Positives = 147/376 (39%), Gaps = 68/376 (18%)
Query: 621 WKQLGTTECSTTCGKGSQYPIFRCV-HRSTHEEAPESYCDSSMKPTPEEEPCNIFPC--- 676
W + ++C+ TCG+G +Y + C+ HR H C+ +K +EE PC
Sbjct: 482 WIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGG----CNPQLKLHIKEECVIPIPCYKP 537
Query: 677 ----------------------------PAFWDIGE-WSECSKTCGLGMQHRQVLCRQV- 706
P F I E WS CS TCG G+Q R+V CR +
Sbjct: 538 KEKSPVEAKLPWLKQAQELEETRIATEEPTF--IPEPWSACSTTCGPGVQVREVKCRVLL 595
Query: 707 -YANRSLTVQPYRCQHLEKPETTSTCQLKICSEW--------------QIRTDW-----T 746
+ + C+ + P T C L+ C E + DW T
Sbjct: 596 TFTQTETELPEEECEGPKLP-TERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFT 654
Query: 747 SCSVPCGVGQRTRDVKCVS-NIGDVVDDEECNMKLRPNDIEN-CDMGPCAKSWFLTEWSE 804
C+ C G + C+ V+D C+M RP + C+ PC W + W
Sbjct: 655 PCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGP 714
Query: 805 RCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNNRPAEATPCDNGPCTGKVEWFAGSWSQC 864
CSA CG G++TR V C+ + P E C + +P C+ C W W QC
Sbjct: 715 -CSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQACNQFDCPPG--WHIEEWQQC 771
Query: 865 SIECGSGTQQREVICVRKNAD-TFEVLDPSECSFLEKPPSQQSCHLKPCGAKWFSTEWSM 923
S CG GTQ R V C + D +F L C K S +SC C +WS
Sbjct: 772 SRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQG-PKASSHKSCARTDCPPHLAVGDWSK 830
Query: 924 CSKSCQGGFRVREVRC 939
CS SC G + R+ C
Sbjct: 831 CSVSCGVGIQRRKQVC 846
Score = 128 bits (321), Expect = 3e-29
Identities = 69/218 (31%), Positives = 108/218 (49%), Gaps = 5/218 (2%)
Query: 273 THGATQSFSQPARSTAISCIGAYRQYKLCNTNVCPESSRSIREVQCASYNNKPFMGRFYE 332
T G S+S T +C G +YK C+ + CP + R QC++YN+ + G +YE
Sbjct: 90 TCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCPPDAEDFRAQQCSAYNDVQYQGHYYE 149
Query: 333 WEPFAEVKGNRKCELNCQAMGYRFYVRQAEKVIDGTPCDQNGTAICVSGQCKSIGCDDYL 392
W P C L C A G V A KV+DGT C+ + +C+SG C+++GCD L
Sbjct: 150 WLPRYNDPA-APCALKCHAQGQNLVVELAPKVLDGTRCNTDSLDMCISGICQAVGCDRQL 208
Query: 393 GSDKVVDKCGVCGGDNTGCQVVSGVFK-HALTSLGYHRVVEIPEGATKINITEMYKSNNY 451
GS+ D CGVC GD + C++V G K H V+ +P G+ + IT ++ +
Sbjct: 209 GSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKREENVIAVPLGSRSVRITVKGPAHLF 268
Query: 452 LALRSRSGRSIINGNWAIDRPGKYEGGGTMFTYKRPNE 489
+ ++ G G + + PG + T ++R +E
Sbjct: 269 IESKTLQGS---KGEHSFNSPGVFLVENTTVEFQRGSE 303
Score = 128 bits (321), Expect = 3e-29
Identities = 91/314 (28%), Positives = 130/314 (41%), Gaps = 39/314 (12%)
Query: 629 CSTTCGKGSQYPIFRC----VHRSTHEEAPESYCDSSMKPTPEEEPCNIFPC---PAF-- 679
CSTTCG G Q +C T E PE C+ PT E PC + C PA
Sbjct: 576 CSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPT--ERPCLLEACDESPASRE 633
Query: 680 --------------WDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKP 725
W+ ++ C+ TC G Q +C + + TV C + +P
Sbjct: 634 LDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQ--TVNDSLCDMVHRP 691
Query: 726 ETTS-TCQLKICS-EWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPN 783
S C + C W + + W CS CGVG +TRDV C+ EEC + +P+
Sbjct: 692 PAMSQACNTEPCPPRWHVGS-WGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDE-KPH 749
Query: 784 DIENCDMGPCAKSWFLTEWSERCSAECGAGVRTRSVVCMT----NHVSSLPLEGCGNNRP 839
++ C+ C W + EW ++CS CG G + R V C +L E C +
Sbjct: 750 ALQACNQFDCPPGWHIEEW-QQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKA 808
Query: 840 AEATPCDNGPCTGKVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEV-LDPSECSFL 898
+ C C + G WS+CS+ CG G Q+R+ +C R A + L C L
Sbjct: 809 SSHKSCARTDCPPHLA--VGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDL 866
Query: 899 EKPPSQQSCHLKPC 912
P +SC + C
Sbjct: 867 PGLPLVRSCQMPEC 880
Score = 123 bits (308), Expect = 1e-27
Identities = 70/217 (32%), Positives = 96/217 (44%), Gaps = 12/217 (5%)
Query: 610 PQPPRRSRDHNWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEE 669
P P ++W+ G T C+ TC G Q I C+H T + +S CD +P +
Sbjct: 637 PLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQ 696
Query: 670 PCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTS 729
CN PCP W +G W CS TCG+G+Q R V C P C+ EKP
Sbjct: 697 ACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLH---PGETPAPPEECRD-EKPHALQ 752
Query: 730 TCQLKICSE-WQIRTDWTSCSVPCGVGQRTRDVKCVSNIGD----VVDDEECNMKLRPND 784
C C W I +W CS CG G + R V C + D + DE C + +
Sbjct: 753 ACNQFDCPPGWHIE-EWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGP-KASS 810
Query: 785 IENCDMGPCAKSWFLTEWSERCSAECGAGVRTRSVVC 821
++C C + +WS +CS CG G++ R VC
Sbjct: 811 HKSCARTDCPPHLAVGDWS-KCSVSCGVGIQRRKQVC 846
Score = 119 bits (297), Expect = 2e-26
Identities = 77/275 (28%), Positives = 119/275 (43%), Gaps = 32/275 (11%)
Query: 744 DWTSCSVPCG-VGQRTRDVKCVSNIGDVVDDEECNMKLRP-NDIENCDMGPCAKSWFLTE 801
+W+ CS CG +G R + +CV G V + C+ +P E C++ C WF +
Sbjct: 1432 NWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCPARWFTSV 1491
Query: 802 WSERCSAECGAGVRTRSVVCMTNHVSSL-----PLEGCGNNRPAEATPCDNGPCTGKVEW 856
WS+ CS CG G +R V C + P +RP PC PC V+W
Sbjct: 1492 WSQ-CSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPC---VQW 1547
Query: 857 FAGSWSQCSIECGSGT---QQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPCG 913
G+ +C C QQR C ++D S C ++P +++C C
Sbjct: 1548 EPGN--RCPGRCMGRAVRMQQRHTACQHNSSD-------SNCDDRKRPTLRRNCTSGACD 1598
Query: 914 AKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLK---PEERESCNPQDCV-P 969
W + W C+ +C GF+ R+V C+ + C P K ++++ + + C+ P
Sbjct: 1599 VCWHTGPWKPCTAACGRGFQSRKVDCIH-----TRSCKPVAKRHCVQKKKPISWRHCLGP 1653
Query: 970 EVDENCKDKYYNCNVVVQARLCVYNYYKTACCASC 1004
D +C D + C V LC + YK CC SC
Sbjct: 1654 SCDRDCTDTTHYCMFVKHLNLCSLDRYKQRCCQSC 1688
Score = 114 bits (285), Expect = 5e-25
Identities = 69/217 (31%), Positives = 99/217 (45%), Gaps = 10/217 (4%)
Query: 608 PAPQPPRRSRDHNWKQLGTTECSTTCGK-GSQYPIFRCVHRSTHEEAPESYCDSSMKPTP 666
P +PP ++ W+ + CS TCG G++ +CV + +E E+ CD KP
Sbjct: 1417 PTGEPP--PQEPFWEPGNWSHCSATCGHLGARIQRPQCV-MANGQEVSEALCDHLQKPLA 1473
Query: 667 EEEPCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSL-TVQPYRCQHLEKP 725
EPCNI CPA W WS+CS +CG G RQV C++ AN ++ V P C ++P
Sbjct: 1474 GFEPCNIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRP 1533
Query: 726 ETTSTCQLKICSEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDI 785
C C +W+ + V + R C N D C+ + RP
Sbjct: 1534 LGRKPCFGHPCVQWEPGNRCPGRCMGRAVRMQQRHTACQHN----SSDSNCDDRKRPTLR 1589
Query: 786 ENCDMGPCAKSWFLTEWSERCSAECGAGVRTRSVVCM 822
NC G C W W + C+A CG G ++R V C+
Sbjct: 1590 RNCTSGACDVCWHTGPW-KPCTAACGRGFQSRKVDCI 1625
Score = 72.0 bits (175), Expect = 3e-12
Identities = 46/156 (29%), Positives = 72/156 (46%), Gaps = 14/156 (8%)
Query: 856 WFAGSWSQCSIECGS-GTQQREVICVRKNADTFEVLDPSECSFLEKPPSQ-QSCHLKPCG 913
W G+WS CS CG G + + CV N + + + C L+KP + + C+++ C
Sbjct: 1428 WEPGNWSHCSATCGHLGARIQRPQCVMANG---QEVSEALCDHLQKPLAGFEPCNIRDCP 1484
Query: 914 AKWFSTEWSMCSKSCQGGFRVREVRCL------SDDMTLSNLCDPQLKPEERESCNPQDC 967
A+WF++ WS CS SC G+ R+V C + + C P+ +P R+ C C
Sbjct: 1485 ARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPC 1544
Query: 968 VP-EVDENCKDKYYNCNVVVQAR--LCVYNYYKTAC 1000
V E C + V +Q R C +N + C
Sbjct: 1545 VQWEPGNRCPGRCMGRAVRMQQRHTACQHNSSDSNC 1580
Score = 58.5 bits (140), Expect = 3e-08
Identities = 38/146 (26%), Positives = 59/146 (40%), Gaps = 17/146 (11%)
Query: 610 PQPPRRSRDHN---------------WKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAP 654
P PP RD W +CS TCG G+Q C T
Sbjct: 737 PAPPEECRDEKPHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFL 796
Query: 655 ESYCDSSMKP-TPEEEPCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYA-NRSL 712
+ P + C CP +G+WS+CS +CG+G+Q R+ +C+++ A R +
Sbjct: 797 NLSDELCQGPKASSHKSCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRI 856
Query: 713 TVQPYRCQHLEKPETTSTCQLKICSE 738
+ C+ L +CQ+ CS+
Sbjct: 857 PLSEMMCRDLPGLPLVRSCQMPECSK 882
Score = 42.4 bits (98), Expect = 0.002
Identities = 16/28 (57%), Positives = 17/28 (60%)
Query: 54 GVWGAWGPWSACSRSCSGGVMEQTRPCL 81
G W AWG WS CSR+C GG R CL
Sbjct: 76 GNWDAWGDWSDCSRTCGGGASYSLRRCL 103
Score = 40.0 bits (92), Expect = 0.011
Identities = 62/298 (20%), Positives = 106/298 (35%), Gaps = 45/298 (15%)
Query: 680 WDI-GEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKICS- 737
WD G+WS+CS+TCG G + C ++ C + + P + + CS
Sbjct: 78 WDAWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCPPDAEDFRAQQCSA 137
Query: 738 -----------EWQIRTDWTSCSVPCGVGQRTRDVKCVSNIG-DVVDDEECNMKLRPNDI 785
EW R + + PC + + V + V+D CN I
Sbjct: 138 YNDVQYQGHYYEWLPR--YNDPAAPCALKCHAQGQNLVVELAPKVLDGTRCNTDSLDMCI 195
Query: 786 EN-CDMGPCAKSWFLTEWSERCSAECGAGVRTRSVVCMT-NHVS---------SLPLEGC 834
C C + + C G G R V + +HVS ++PL
Sbjct: 196 SGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKREENVIAVPL--- 252
Query: 835 GNNRPAEATPCDNGPCTGKVE--WFAGSWSQCSIEC-GSGTQQREVICVRKNAD--TFEV 889
+R T GP +E GS + S G + + ++ ++ TF++
Sbjct: 253 -GSRSVRITV--KGPAHLFIESKTLQGSKGEHSFNSPGVFLVENTTVEFQRGSERQTFKI 309
Query: 890 LDPSECSFL-------EKPPSQQSCHLKPCGAKWFSTEWSMCSKSCQGGFRVREVRCL 940
P F+ K Q +P +W T++ C+ +C GG+++ C+
Sbjct: 310 PGPLMADFIFKTRYTAAKDSVVQFFFYQPISHQWRQTDFFPCTVTCGGGYQLNSAECV 367
Score = 34.3 bits (77), Expect = 0.61
Identities = 22/69 (31%), Positives = 32/69 (46%), Gaps = 4/69 (5%)
Query: 617 RDHNWKQLGT-TECSTTCGKGSQYPIFRCVHRSTHEEAPESY--CDSSMKPTPEEEPCNI 673
+D NW G ++CS TCG G+ Y + RC+ E Y C + P P+ E
Sbjct: 74 KDGNWDAWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCP-PDAEDFRA 132
Query: 674 FPCPAFWDI 682
C A+ D+
Sbjct: 133 QQCSAYNDV 141
Score = 32.0 bits (71), Expect = 3.0
Identities = 11/24 (45%), Positives = 16/24 (66%)
Query: 61 PWSACSRSCSGGVMEQTRPCLPRS 84
PW+ACS SC GG+ ++ C+ S
Sbjct: 426 PWTACSVSCGGGIQRRSFVCVEES 449
Score = 30.8 bits (68), Expect = 6.8
Identities = 16/54 (29%), Positives = 27/54 (50%), Gaps = 7/54 (12%)
Query: 920 EWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERESCNPQDCVPEVDE 973
+WS CS++C GG RCL+ C+ Q ++C+ DC P+ ++
Sbjct: 83 DWSDCSRTCGGGASYSLRRCLT-----GRNCEGQ--NIRYKTCSNHDCPPDAED 129
>gi|21265052 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 2 preproprotein [Homo sapiens]
Length = 1223
Score = 166 bits (421), Expect = 8e-41
Identities = 145/489 (29%), Positives = 214/489 (43%), Gaps = 50/489 (10%)
Query: 266 SNNHGVGTHGATQSFSQPARSTAIS-CIGAYRQYKLCNTNVCPESSRSIREVQCASYNNK 324
S + G G ++S + P+ + C+G +Y++CN+ CP + R QCA N+
Sbjct: 565 SRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTYEDFRAQQCAKRNSY 624
Query: 325 -PFMGRFYEWEPFAEVKGNRKCELNCQAMGYRFYVRQAEKVIDGTPCD-QNGTAICVSGQ 382
+ W P+ +KCEL CQ+ V + V DGT C ++ ++C G+
Sbjct: 625 YVHQNAKHSWVPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTRCSYRDPYSVCARGE 684
Query: 383 CKSIGCDDYLGSDKVVDKCGVCGGDNTGCQVVSGVFKHALTSLGYHRVVEIPEGATKINI 442
C +GCD +GS K DKCGVCGGDN+ C+ V G A G ++V+IP GA I I
Sbjct: 685 CVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGALKLVQIPAGARHIQI 744
Query: 443 TEMYKSNNYLALRSRSGRSIINGNWAIDRPGKYEGGGTMFTYK--RPNEISSTAGESFLA 500
+ KS + + ++++ + G++ ++ GK E FT + A ES
Sbjct: 745 EALEKSPHRIVVKNQ-----VTGSFILNPKGK-EATSRTFTAMGLEWEDAVEDAKESLKT 798
Query: 501 EGPTNEILDVYMI---HQQPNPGVHYEYVIMGTNAISPQVPPHRRPGEPFNGQMVTEGRS 557
GP E + + + P + Y+YVI + P + + ++ E
Sbjct: 799 SGPLPEAIAILALPPTEGGPRSSLAYKYVI--HEDLLPLIG---------SNNVLLEEMD 847
Query: 558 QEEGEQKGRNEEKEDLRGEAPEMFTSESAQTFPVRHPDRFSPHRPDNLVPPAPQPPRRSR 617
E K + G FT + H H D+ P P RR
Sbjct: 848 TYEWALKSWAPCSKACGGGI--QFTKYGCRRRRDHH--MVQRHLCDHKKRPKP-IRRRCN 902
Query: 618 DHNWKQ-LGTTE----CSTTCGK-GSQYPIFRC---VHRSTHEEAPESYCDSSMKPTPE- 667
H Q + TE CS +CGK G Q +C + TH+ P C PE
Sbjct: 903 QHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGD---RPEA 959
Query: 668 EEPCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPET 727
PC PCPA W +G WS+CS TCG G+Q RQV+CR AN SL C+ ++P+T
Sbjct: 960 RRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCR-TNAN-SLG----HCEG-DRPDT 1012
Query: 728 TSTCQLKIC 736
C L C
Sbjct: 1013 VQVCSLPAC 1021
Score = 93.6 bits (231), Expect = 9e-19
Identities = 53/178 (29%), Positives = 78/178 (43%), Gaps = 8/178 (4%)
Query: 619 HNWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPC-P 677
+ W CS CG G Q+ + C R H CD +P P CN PC
Sbjct: 849 YEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQ 908
Query: 678 AFWDIGEWSECSKTCG-LGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKIC 736
W EW CS++CG LG+Q R + C +N + V P + ++PE C C
Sbjct: 909 PVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPC 968
Query: 737 -SEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCDMGPC 793
++W++ W+ CS CG G + R V C +N + E RP+ ++ C + C
Sbjct: 969 PAQWRLGA-WSQCSATCGEGIQQRQVVCRTNANSLGHCEGD----RPDTVQVCSLPAC 1021
Score = 76.3 bits (186), Expect = 1e-13
Identities = 61/252 (24%), Positives = 99/252 (39%), Gaps = 43/252 (17%)
Query: 797 WFLTEWSERCSAECGAGVRTRSVVCMT---NHVSSLPLEGCGNNRPAEATPCDNGPCTGK 853
W L W+ CS CG G++ C +H+ L C+ PC+
Sbjct: 851 WALKSWAP-CSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQP 909
Query: 854 VEWFAGSWSQCSIECGS-GTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPC 912
V W W CS CG G Q R + C+ ++ + P++ ++P +++ C PC
Sbjct: 910 V-WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPC 968
Query: 913 GAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERESCNPQDC----- 967
A+W WS CS +C G + R+V C ++ +L + C+ +P+ + C+ C
Sbjct: 969 PAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGH-CEGD-RPDTVQVCSLPACGGNHQ 1026
Query: 968 ------------------VPEVD-----------ENCK-DKYYNCNVVVQARLCVYNYYK 997
VP+ + E C D+ C + V R C Y
Sbjct: 1027 NSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLDRYCSIPGYH 1086
Query: 998 TACCASCTRVAN 1009
CC SC + A+
Sbjct: 1087 RLCCVSCIKKAS 1098
Score = 55.1 bits (131), Expect = 3e-07
Identities = 37/124 (29%), Positives = 56/124 (45%), Gaps = 16/124 (12%)
Query: 855 EWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKP-PSQQSCHLKPCG 913
EW SW+ CS CG G Q + C R+ ++ C ++P P ++ C+ PC
Sbjct: 850 EWALKSWAPCSKACGGGIQFTKYGCRRRR--DHHMVQRHLCDHKKRPKPIRRRCNQHPCS 907
Query: 914 AK-WFSTEWSMCSKSC-QGGFRVREVRCLSDDMTLSNLCDPQL--------KPEERESCN 963
W + EW CS+SC + G + R ++CL + LSN + +PE R C
Sbjct: 908 QPVWVTEEWGACSRSCGKLGVQTRGIQCL---LPLSNGTHKVMPAKACAGDRPEARRPCL 964
Query: 964 PQDC 967
C
Sbjct: 965 RVPC 968
Score = 39.3 bits (90), Expect = 0.019
Identities = 14/30 (46%), Positives = 19/30 (63%)
Query: 51 GAPGVWGAWGPWSACSRSCSGGVMEQTRPC 80
G G W +W + +CSRSC GGV ++R C
Sbjct: 550 GQDGGWSSWTKFGSCSRSCGGGVRSRSRSC 579
Score = 31.6 bits (70), Expect = 4.0
Identities = 41/172 (23%), Positives = 63/172 (36%), Gaps = 36/172 (20%)
Query: 620 NWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPCPAF 679
+W + G+ CS +CG G R RS + +P + P E + CN CP
Sbjct: 557 SWTKFGS--CSRSCGGG-----VRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGT 609
Query: 680 WDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKICSEW 739
++ +C+K V+ N + PY E + C+L IC
Sbjct: 610 YEDFRAQQCAKRNSY----------YVHQNAKHSWVPY-----EPDDDAQKCEL-ICQSA 653
Query: 740 ---------QIRTDWTSCSV--PCGVGQRTR--DVKCVSNIGDVVDDEECNM 778
Q+ D T CS P V R V C +G + D++C +
Sbjct: 654 DTGDVVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGV 705
Score = 30.4 bits (67), Expect = 8.9
Identities = 19/66 (28%), Positives = 28/66 (42%), Gaps = 9/66 (13%)
Query: 739 WQIRTDWTSCSVPCGVGQRTRDVKCVSN---------IGDVVDDEECNMKLRPNDIENCD 789
W T + SCS CG G R+R C + +G + + + CN + P E+
Sbjct: 555 WSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTYEDFR 614
Query: 790 MGPCAK 795
CAK
Sbjct: 615 AQQCAK 620
Score = 30.4 bits (67), Expect = 8.9
Identities = 18/65 (27%), Positives = 27/65 (41%), Gaps = 4/65 (6%)
Query: 19 GFQFVCPQPSTQHRKVPQRMAAEGAPEDDGGG---GAPGVWGAWGPWSACSRSCSGGVME 75
G Q + P + H+ +P + A PE P W G WS CS +C G+ +
Sbjct: 932 GIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPCPAQWRL-GAWSQCSATCGEGIQQ 990
Query: 76 QTRPC 80
+ C
Sbjct: 991 RQVVC 995
>gi|110611167 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 1 preproprotein [Homo sapiens]
Length = 1226
Score = 166 bits (421), Expect = 8e-41
Identities = 145/489 (29%), Positives = 214/489 (43%), Gaps = 50/489 (10%)
Query: 266 SNNHGVGTHGATQSFSQPARSTAIS-CIGAYRQYKLCNTNVCPESSRSIREVQCASYNNK 324
S + G G ++S + P+ + C+G +Y++CN+ CP + R QCA N+
Sbjct: 568 SRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTYEDFRAQQCAKRNSY 627
Query: 325 -PFMGRFYEWEPFAEVKGNRKCELNCQAMGYRFYVRQAEKVIDGTPCD-QNGTAICVSGQ 382
+ W P+ +KCEL CQ+ V + V DGT C ++ ++C G+
Sbjct: 628 YVHQNAKHSWVPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTRCSYRDPYSVCARGE 687
Query: 383 CKSIGCDDYLGSDKVVDKCGVCGGDNTGCQVVSGVFKHALTSLGYHRVVEIPEGATKINI 442
C +GCD +GS K DKCGVCGGDN+ C+ V G A G ++V+IP GA I I
Sbjct: 688 CVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGALKLVQIPAGARHIQI 747
Query: 443 TEMYKSNNYLALRSRSGRSIINGNWAIDRPGKYEGGGTMFTYK--RPNEISSTAGESFLA 500
+ KS + + ++++ + G++ ++ GK E FT + A ES
Sbjct: 748 EALEKSPHRIVVKNQ-----VTGSFILNPKGK-EATSRTFTAMGLEWEDAVEDAKESLKT 801
Query: 501 EGPTNEILDVYMI---HQQPNPGVHYEYVIMGTNAISPQVPPHRRPGEPFNGQMVTEGRS 557
GP E + + + P + Y+YVI + P + + ++ E
Sbjct: 802 SGPLPEAIAILALPPTEGGPRSSLAYKYVI--HEDLLPLIG---------SNNVLLEEMD 850
Query: 558 QEEGEQKGRNEEKEDLRGEAPEMFTSESAQTFPVRHPDRFSPHRPDNLVPPAPQPPRRSR 617
E K + G FT + H H D+ P P RR
Sbjct: 851 TYEWALKSWAPCSKACGGGI--QFTKYGCRRRRDHH--MVQRHLCDHKKRPKP-IRRRCN 905
Query: 618 DHNWKQ-LGTTE----CSTTCGK-GSQYPIFRC---VHRSTHEEAPESYCDSSMKPTPE- 667
H Q + TE CS +CGK G Q +C + TH+ P C PE
Sbjct: 906 QHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGD---RPEA 962
Query: 668 EEPCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPET 727
PC PCPA W +G WS+CS TCG G+Q RQV+CR AN SL C+ ++P+T
Sbjct: 963 RRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCR-TNAN-SLG----HCEG-DRPDT 1015
Query: 728 TSTCQLKIC 736
C L C
Sbjct: 1016 VQVCSLPAC 1024
Score = 93.6 bits (231), Expect = 9e-19
Identities = 53/178 (29%), Positives = 78/178 (43%), Gaps = 8/178 (4%)
Query: 619 HNWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPC-P 677
+ W CS CG G Q+ + C R H CD +P P CN PC
Sbjct: 852 YEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQ 911
Query: 678 AFWDIGEWSECSKTCG-LGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKIC 736
W EW CS++CG LG+Q R + C +N + V P + ++PE C C
Sbjct: 912 PVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPC 971
Query: 737 -SEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCDMGPC 793
++W++ W+ CS CG G + R V C +N + E RP+ ++ C + C
Sbjct: 972 PAQWRLGA-WSQCSATCGEGIQQRQVVCRTNANSLGHCEGD----RPDTVQVCSLPAC 1024
Score = 76.3 bits (186), Expect = 1e-13
Identities = 61/252 (24%), Positives = 99/252 (39%), Gaps = 43/252 (17%)
Query: 797 WFLTEWSERCSAECGAGVRTRSVVCMT---NHVSSLPLEGCGNNRPAEATPCDNGPCTGK 853
W L W+ CS CG G++ C +H+ L C+ PC+
Sbjct: 854 WALKSWAP-CSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQP 912
Query: 854 VEWFAGSWSQCSIECGS-GTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPC 912
V W W CS CG G Q R + C+ ++ + P++ ++P +++ C PC
Sbjct: 913 V-WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPC 971
Query: 913 GAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERESCNPQDC----- 967
A+W WS CS +C G + R+V C ++ +L + C+ +P+ + C+ C
Sbjct: 972 PAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGH-CEGD-RPDTVQVCSLPACGGNHQ 1029
Query: 968 ------------------VPEVD-----------ENCK-DKYYNCNVVVQARLCVYNYYK 997
VP+ + E C D+ C + V R C Y
Sbjct: 1030 NSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLDRYCSIPGYH 1089
Query: 998 TACCASCTRVAN 1009
CC SC + A+
Sbjct: 1090 RLCCVSCIKKAS 1101
Score = 55.1 bits (131), Expect = 3e-07
Identities = 37/124 (29%), Positives = 56/124 (45%), Gaps = 16/124 (12%)
Query: 855 EWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKP-PSQQSCHLKPCG 913
EW SW+ CS CG G Q + C R+ ++ C ++P P ++ C+ PC
Sbjct: 853 EWALKSWAPCSKACGGGIQFTKYGCRRRR--DHHMVQRHLCDHKKRPKPIRRRCNQHPCS 910
Query: 914 AK-WFSTEWSMCSKSC-QGGFRVREVRCLSDDMTLSNLCDPQL--------KPEERESCN 963
W + EW CS+SC + G + R ++CL + LSN + +PE R C
Sbjct: 911 QPVWVTEEWGACSRSCGKLGVQTRGIQCL---LPLSNGTHKVMPAKACAGDRPEARRPCL 967
Query: 964 PQDC 967
C
Sbjct: 968 RVPC 971
Score = 39.3 bits (90), Expect = 0.019
Identities = 14/30 (46%), Positives = 19/30 (63%)
Query: 51 GAPGVWGAWGPWSACSRSCSGGVMEQTRPC 80
G G W +W + +CSRSC GGV ++R C
Sbjct: 553 GQDGGWSSWTKFGSCSRSCGGGVRSRSRSC 582
Score = 31.6 bits (70), Expect = 4.0
Identities = 41/172 (23%), Positives = 63/172 (36%), Gaps = 36/172 (20%)
Query: 620 NWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPCPAF 679
+W + G+ CS +CG G R RS + +P + P E + CN CP
Sbjct: 560 SWTKFGS--CSRSCGGG-----VRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGT 612
Query: 680 WDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKICSEW 739
++ +C+K V+ N + PY E + C+L IC
Sbjct: 613 YEDFRAQQCAKRNSY----------YVHQNAKHSWVPY-----EPDDDAQKCEL-ICQSA 656
Query: 740 ---------QIRTDWTSCSV--PCGVGQRTR--DVKCVSNIGDVVDDEECNM 778
Q+ D T CS P V R V C +G + D++C +
Sbjct: 657 DTGDVVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGV 708
Score = 30.4 bits (67), Expect = 8.9
Identities = 19/66 (28%), Positives = 28/66 (42%), Gaps = 9/66 (13%)
Query: 739 WQIRTDWTSCSVPCGVGQRTRDVKCVSN---------IGDVVDDEECNMKLRPNDIENCD 789
W T + SCS CG G R+R C + +G + + + CN + P E+
Sbjct: 558 WSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTYEDFR 617
Query: 790 MGPCAK 795
CAK
Sbjct: 618 AQQCAK 623
Score = 30.4 bits (67), Expect = 8.9
Identities = 18/65 (27%), Positives = 27/65 (41%), Gaps = 4/65 (6%)
Query: 19 GFQFVCPQPSTQHRKVPQRMAAEGAPEDDGGG---GAPGVWGAWGPWSACSRSCSGGVME 75
G Q + P + H+ +P + A PE P W G WS CS +C G+ +
Sbjct: 935 GIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPCPAQWRL-GAWSQCSATCGEGIQQ 993
Query: 76 QTRPC 80
+ C
Sbjct: 994 RQVVC 998
>gi|110825974 ADAM metallopeptidase with thrombospondin type 1 motif,
2 isoform 1 preproprotein [Homo sapiens]
Length = 1211
Score = 164 bits (414), Expect = 5e-40
Identities = 137/487 (28%), Positives = 208/487 (42%), Gaps = 48/487 (9%)
Query: 266 SNNHGVGTHGATQSFSQPARSTA-ISCIGAYRQYKLCNTNVCPESSRSIREVQCASYNNK 324
S G G T+ P + +C G ++LC+ CP+S RE QC ++
Sbjct: 574 SRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCSRQDCPDSLADFREEQCRQWDLY 633
Query: 325 PFMGRF-YEWEPFAEVKGNRKCELNCQAMGYRFYVRQAEKVIDGTPCD-QNGTAICVSGQ 382
G + W P +C L C++ V V DGT C ++ ++CV G
Sbjct: 634 FEHGDAQHHWLPHEHRDAKERCHLYCESRETGEVVSMKRMVHDGTRCSYKDAFSLCVRGD 693
Query: 383 CKSIGCDDYLGSDKVVDKCGVCGGDNTGCQVVSGVFKHALTSLGYHRVVEIPEGATKINI 442
C+ +GCD +GS K DKCGVCGGDN+ C+VV G F + GY ++ EIP GA + I
Sbjct: 694 CRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKGTFTRSPKKHGYIKMFEIPAGARHLLI 753
Query: 443 TEMYKSNNYLALRS-RSGRSIINGNWAIDRPGK-YEGGGTMFTYKRPNEISSTAGESFLA 500
E+ ++++LA+++ +G+ I+N +D K + G + Y+ E+
Sbjct: 754 QEVDATSHHLAVKNLETGKFILNEENDVDASSKTFIAMGVEWEYR-----DEDGRETLQT 808
Query: 501 EGPTNEILDVYMIH-QQPNPGVHYEYVIMGTNAISPQVPPHRRPGEPFNGQMVTEGRSQE 559
GP + + V +I + Y+Y+I H + ++ E
Sbjct: 809 MGPLHGTITVLVIPVGDTRVSLTYKYMI------------HEDSLNVDDNNVLEEDSVVY 856
Query: 560 EGEQKGRNEEKEDLRGEAPEMFTSESAQTFPVRHPDRFSPHRPDNLVPPAPQPPRRSRDH 619
E K + + G + FT + R D HR P+ RR+ +
Sbjct: 857 EWALKKWSPCSKPCGGGS--QFTKYGCR----RRLDHKMVHRGFCAALSKPKAIRRACNP 910
Query: 620 N------WKQLGTTECSTTCGK-GSQYPIFRCV---HRSTHEEAPESYCDSSMKPTPEEE 669
W CS TCG+ G Q RC+ H +T +C+ + +
Sbjct: 911 QECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPES--RR 968
Query: 670 PCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTS 729
C+ CP W G WS+CS TCG G Q R VLCR A+ S + CQ E+PET
Sbjct: 969 ACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLCRT--ADDSFGI----CQE-ERPETAR 1021
Query: 730 TCQLKIC 736
TC+L C
Sbjct: 1022 TCRLGPC 1028
Score = 100 bits (250), Expect = 5e-21
Identities = 81/283 (28%), Positives = 119/283 (42%), Gaps = 52/283 (18%)
Query: 738 EWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGD-VVDDEECNMKLRPNDIEN-CDMGPCAK 795
EW ++ W+ CS PCG G + C + +V C +P I C+ C++
Sbjct: 857 EWALKK-WSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQ 915
Query: 796 S-WFLTEWSERCSAECG-AGVRTRSVVCMT----NHVSSLPLEGCGNNRPAEATPCDNGP 849
W EW E CS CG G++ RSV C+ N S+ + C + RP C
Sbjct: 916 PVWVTGEW-EPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACSREL 974
Query: 850 CTGKVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHL 909
C G+ W AG WSQCS+ CG+GTQ+R V+C R D+F + E+P + ++C L
Sbjct: 975 CPGR--WRAGPWSQCSVTCGNGTQERPVLC-RTADDSFGICQE------ERPETARTCRL 1025
Query: 910 KPCGAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERESCNPQDCVP 969
PC R +SD S + +P+ P +
Sbjct: 1026 GPC------------------------PRNISDPSKKSYVVQWLSRPD------PDSPIR 1055
Query: 970 EVDE--NCK-DKYYNCNVVVQARLCVYNYYKTACCASCTRVAN 1009
++ +C+ DK C + V +R C Y CC SC N
Sbjct: 1056 KISSKGHCQGDKSIFCRMEVLSRYCSIPGYNKLCCKSCNLYNN 1098
Score = 97.1 bits (240), Expect = 8e-20
Identities = 60/197 (30%), Positives = 85/197 (43%), Gaps = 15/197 (7%)
Query: 619 HNWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPC-P 677
+ W + CS CG GSQ+ + C R H+ +C + KP CN C
Sbjct: 856 YEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQ 915
Query: 678 AFWDIGEWSECSKTCG-LGMQHRQVLCRQ-VYANRSLTVQPYRCQHLEKPETTSTCQLKI 735
W GEW CS+TCG GMQ R V C Q ++ N + +V C +PE+ C ++
Sbjct: 916 PVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCND-ARPESRRACSREL 974
Query: 736 CSEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCDMGPC-- 793
C W+ CSV CG G + R V C + D + RP C +GPC
Sbjct: 975 CPGRWRAGPWSQCSVTCGNGTQERPVLCRT----ADDSFGICQEERPETARTCRLGPCPR 1030
Query: 794 -----AKSWFLTEWSER 805
+K ++ +W R
Sbjct: 1031 NISDPSKKSYVVQWLSR 1047
Score = 41.6 bits (96), Expect = 0.004
Identities = 15/27 (55%), Positives = 19/27 (70%)
Query: 54 GVWGAWGPWSACSRSCSGGVMEQTRPC 80
G WGAW P+ +CSR+C GV +TR C
Sbjct: 562 GSWGAWSPFGSCSRTCGTGVKFRTRQC 588
Score = 33.1 bits (74), Expect = 1.4
Identities = 17/32 (53%), Positives = 19/32 (59%), Gaps = 3/32 (9%)
Query: 53 PGVWGAWGPWSACSRSCSGGVMEQTRPCLPRS 84
PG W A GPWS CS +C G E RP L R+
Sbjct: 976 PGRWRA-GPWSQCSVTCGNGTQE--RPVLCRT 1004
>gi|50845384 ADAM metallopeptidase with thrombospondin type 1 motif,
1 preproprotein [Homo sapiens]
Length = 967
Score = 147 bits (371), Expect = 5e-35
Identities = 118/406 (29%), Positives = 184/406 (45%), Gaps = 57/406 (14%)
Query: 291 CIGAYRQYKLCNTNVCPESS-RSIREVQCASYN--NKPFMGR--FYEWEP-FAEVKGNRK 344
C G +Y+ CN CP+++ ++ RE QC ++N +K G EW P +A V +
Sbjct: 598 CEGKRVRYRSCNLEDCPDNNGKTFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDR 657
Query: 345 CELNCQAMGYRFYVRQAEKVIDGTPCDQNGTAICVSGQCKSIGCDDYLGSDKVVDKCGVC 404
C+L CQA G ++ KV+DGTPC + T++CV GQC GCD + S K DKCGVC
Sbjct: 658 CKLICQAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVC 717
Query: 405 GGDNTGCQVVSGVFKHALTSLGYHRVVEIPEGATKINITEMYK-----SNNYLALRSRSG 459
GG+ + C+ +SG A GYH ++ IP GAT I + + + + ++LA+++ G
Sbjct: 718 GGNGSTCKKISGSVTSA--KPGYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAADG 775
Query: 460 RSIINGNW---AIDRPGKYEGGGTMFTYKRPNEISSTAGESFLAEGPTNE--ILDVYMIH 514
I+NG++ +++ Y+ G + Y SS A E + P E + V +
Sbjct: 776 TYILNGDYTLSTLEQDIMYK--GVVLRYSG----SSAALERIRSFSPLKEPLTIQVLTVG 829
Query: 515 QQPNPGVHYEYVIMGTNAISPQVPPHRRPGEPFNGQMVTE----GRSQEEGEQKGRNEEK 570
P + Y Y + +P F+ ++ E +S E G Q+ R E
Sbjct: 830 NALRPKIKYTYFVKKKKESFNAIP-------TFSAWVIEEWGECSKSCELGWQR-RLVEC 881
Query: 571 EDLRGEAPEMFTSESAQTFPVRHPDRFSPHRPDNLVPPAPQPPRRSRDHNWKQLGTTECS 630
D+ G+ SE A+ + H P PQ W+ + CS
Sbjct: 882 RDINGQP----ASECAKEVKPASTRPCADH-------PCPQ---------WQLGEWSSCS 921
Query: 631 TTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPC 676
TCGKG + +C+ + ES CD KP + C + C
Sbjct: 922 KTCGKGYKKRSLKCLSHDGGVLSHES-CDPLKKPKHFIDFCTMAEC 966
Score = 89.7 bits (221), Expect = 1e-17
Identities = 47/129 (36%), Positives = 67/129 (51%), Gaps = 7/129 (5%)
Query: 667 EEEPCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPE 726
++E N P + W I EW ECSK+C LG Q R V CR + + C KP
Sbjct: 845 KKESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPA-----SECAKEVKPA 899
Query: 727 TTSTCQLKICSEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPND-I 785
+T C C +WQ+ +W+SCS CG G + R +KC+S+ G V+ E C+ +P I
Sbjct: 900 STRPCADHPCPQWQL-GEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFI 958
Query: 786 ENCDMGPCA 794
+ C M C+
Sbjct: 959 DFCTMAECS 967
Score = 69.7 bits (169), Expect = 1e-11
Identities = 41/115 (35%), Positives = 55/115 (47%), Gaps = 9/115 (7%)
Query: 856 WFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPCGAK 915
W W +CS C G Q+R V C N SEC+ KP S + C PC +
Sbjct: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQP-----ASECAKEVKPASTRPCADHPC-PQ 911
Query: 916 WFSTEWSMCSKSCQGGFRVREVRCLSDD--MTLSNLCDPQLKPEE-RESCNPQDC 967
W EWS CSK+C G++ R ++CLS D + CDP KP+ + C +C
Sbjct: 912 WQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFIDFCTMAEC 966
Score = 66.2 bits (160), Expect = 1e-10
Identities = 37/111 (33%), Positives = 51/111 (45%), Gaps = 10/111 (9%)
Query: 792 PCAKSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNN-RPAEATPCDNGPC 850
P +W + EW E CS C G + R V C ++ P C +PA PC + PC
Sbjct: 853 PTFSAWVIEEWGE-CSKSCELGWQRRLVEC--RDINGQPASECAKEVKPASTRPCADHPC 909
Query: 851 TGKVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKP 901
+W G WS CS CG G ++R + C+ + VL C L+KP
Sbjct: 910 P---QWQLGEWSSCSKTCGKGYKKRSLKCLSHDGG---VLSHESCDPLKKP 954
Score = 45.4 bits (106), Expect = 3e-04
Identities = 16/27 (59%), Positives = 17/27 (62%)
Query: 54 GVWGAWGPWSACSRSCSGGVMEQTRPC 80
G WG WGPW CSR+C GGV R C
Sbjct: 560 GSWGMWGPWGDCSRTCGGGVQYTMREC 586
Score = 41.2 bits (95), Expect = 0.005
Identities = 19/64 (29%), Positives = 31/64 (48%)
Query: 904 QQSCHLKPCGAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERESCN 963
++S + P + W EW CSKSC+ G++ R V C + ++ C ++KP C
Sbjct: 846 KESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCA 905
Query: 964 PQDC 967
C
Sbjct: 906 DHPC 909
Score = 34.7 bits (78), Expect = 0.47
Identities = 34/122 (27%), Positives = 40/122 (32%), Gaps = 29/122 (23%)
Query: 806 CSAECGAGVRTRSVVCMTNHVSSLPLEGCGNNRPAEATPCDNGPCTGKVE---------- 855
CS G +VC T H CG E C NG C K +
Sbjct: 506 CSTLWCTGTSGGVLVCQTKHFPWADGTSCG-----EGKWCINGKCVNKTDRKHFDTPFHG 560
Query: 856 -W-FAGSWSQCSIECGSGTQQREVIC---VRKNADTFEVLDPSECSFLEKPPSQQSCHLK 910
W G W CS CG G Q C V KN + C K +SC+L+
Sbjct: 561 SWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKY-------CE--GKRVRYRSCNLE 611
Query: 911 PC 912
C
Sbjct: 612 DC 613
>gi|153792351 ADAM metallopeptidase with thrombospondin type 1
motif, 8 preproprotein [Homo sapiens]
Length = 889
Score = 139 bits (351), Expect = 1e-32
Identities = 75/188 (39%), Positives = 103/188 (54%), Gaps = 11/188 (5%)
Query: 291 CIGAYRQYKLCNTNVCPESSRSIREVQCASYNNKPFM---GRFYEWEP-FAEVKGNRKCE 346
C+G +Y+ C+T CP +S RE QC YN + G +W P +A V +C+
Sbjct: 565 CLGRRAKYQSCHTEECPPDGKSFREQQCEKYNAYNYTDMDGNLLQWVPKYAGVSPRDRCK 624
Query: 347 LNCQAMGYRFYVRQAEKVIDGTPCDQNGTAICVSGQCKSIGCDDYLGSDKVVDKCGVCGG 406
L C+A G + KVIDGT C AICV GQC GCD + S + +DKCGVCGG
Sbjct: 625 LFCRARGRSEFKVFEAKVIDGTLCGPETLAICVRGQCVKAGCDHVVDSPRKLDKCGVCGG 684
Query: 407 DNTGCQVVSGVFKHALTSLGYHRVVEIPEGATKINITE-----MYKSNNYLALRSRSGRS 461
C+ VSG T+ GY+ +V IP GAT I++ + + NYLAL++ G+
Sbjct: 685 KGNSCRKVSGSL--TPTNYGYNDIVTIPAGATNIDVKQRSHPGVQNDGNYLALKTADGQY 742
Query: 462 IINGNWAI 469
++NGN AI
Sbjct: 743 LLNGNLAI 750
Score = 56.6 bits (135), Expect = 1e-07
Identities = 31/80 (38%), Positives = 38/80 (47%), Gaps = 7/80 (8%)
Query: 659 DSSMKPTPEEEPCNIFP--CPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQP 716
D SM+ + E NI A W +G+WSECS TCG G Q R V CR S T
Sbjct: 813 DFSMQSSKERATTNIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVECRDPSGQASAT--- 869
Query: 717 YRCQHLEKPETTSTCQLKIC 736
C KPE C+ ++C
Sbjct: 870 --CNKALKPEDAKPCESQLC 887
Score = 47.0 bits (110), Expect = 9e-05
Identities = 20/54 (37%), Positives = 28/54 (51%)
Query: 914 AKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERESCNPQDC 967
A+W +WS CS +C G++ R V C S C+ LKPE+ + C Q C
Sbjct: 834 AQWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLC 887
Score = 45.1 bits (105), Expect = 3e-04
Identities = 21/51 (41%), Positives = 27/51 (52%), Gaps = 5/51 (9%)
Query: 35 PQRMAAEGA--PEDDGGGGAP---GVWGAWGPWSACSRSCSGGVMEQTRPC 80
P + +EG+ PE++ P G W WGPW CSR+C GGV R C
Sbjct: 503 PGHLCSEGSCLPEEEVERPKPVADGGWAPWGPWGECSRTCGGGVQFSHREC 553
Score = 44.7 bits (104), Expect = 5e-04
Identities = 23/77 (29%), Positives = 37/77 (48%), Gaps = 3/77 (3%)
Query: 717 YRCQHLEKPETTSTCQLKICSEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEEC 776
+ Q ++ TT+ Q + ++W + DW+ CS CG G + R V+C G C
Sbjct: 814 FSMQSSKERATTNIIQPLLHAQW-VLGDWSECSSTCGAGWQRRTVECRDPSGQA--SATC 870
Query: 777 NMKLRPNDIENCDMGPC 793
N L+P D + C+ C
Sbjct: 871 NKALKPEDAKPCESQLC 887
Score = 38.9 bits (89), Expect = 0.025
Identities = 18/58 (31%), Positives = 27/58 (46%), Gaps = 5/58 (8%)
Query: 855 EWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPC 912
+W G WS+CS CG+G Q+R V C + + C+ KP + C + C
Sbjct: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQA-----SATCNKALKPEDAKPCESQLC 887
Score = 37.4 bits (85), Expect = 0.072
Identities = 21/55 (38%), Positives = 29/55 (52%), Gaps = 4/55 (7%)
Query: 797 WFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNN-RPAEATPCDNGPC 850
W L +WSE CS+ CGAG + R+V C S C +P +A PC++ C
Sbjct: 836 WVLGDWSE-CSSTCGAGWQRRTVEC--RDPSGQASATCNKALKPEDAKPCESQLC 887
Score = 33.1 bits (74), Expect = 1.4
Identities = 41/167 (24%), Positives = 55/167 (32%), Gaps = 34/167 (20%)
Query: 773 DEECNMKLRPNDIENCD----MGPCAKSWFLTEWSER-CSAECGAGVRTRSVVCMTNHVS 827
D++C P D +C CA+ W T+ +E C + G+ C H+
Sbjct: 449 DQQCRQIFGP-DFRHCPNTSAQDVCAQLWCHTDGAEPLCHTKNGSLPWADGTPCGPGHLC 507
Query: 828 S----LPLEGCGNNRPAEATPCDNGPCTGKVEWFAGSWSQCSIECGSGTQQREVICVRKN 883
S LP E +P G W G W +CS CG G Q C
Sbjct: 508 SEGSCLPEEEVERPKPVADG--------GWAPW--GPWGECSRTCGGGVQFSHREC---- 553
Query: 884 ADTFEVLDPSECS----FLEKPPSQQSCHLKPCGAKWFSTEWSMCSK 926
DP + L + QSCH + C S C K
Sbjct: 554 ------KDPEPQNGGRYCLGRRAKYQSCHTEECPPDGKSFREQQCEK 594
Score = 32.3 bits (72), Expect = 2.3
Identities = 18/51 (35%), Positives = 25/51 (49%), Gaps = 4/51 (7%)
Query: 627 TECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPCP 677
+ECS+TCG G Q C S A C+ ++KP + +PC CP
Sbjct: 842 SECSSTCGAGWQRRTVECRDPSGQASAT---CNKALKP-EDAKPCESQLCP 888
Score = 30.4 bits (67), Expect = 8.9
Identities = 11/22 (50%), Positives = 14/22 (63%)
Query: 683 GEWSECSKTCGLGMQHRQVLCR 704
G W ECS+TCG G+Q C+
Sbjct: 533 GPWGECSRTCGGGVQFSHRECK 554
>gi|195539372 ADAM metallopeptidase with thrombospondin type 1
motif, 5 preproprotein [Homo sapiens]
Length = 930
Score = 136 bits (343), Expect = 9e-32
Identities = 94/289 (32%), Positives = 133/289 (46%), Gaps = 22/289 (7%)
Query: 264 ETSNNHGVGTHGATQSFSQPA-RSTAISCIGAYRQYKLCNTNVCPESSRSIREVQCASYN 322
+ S + G G A + + PA R+ C G Y+ C+ CP + +S R QC + N
Sbjct: 578 QCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKN 637
Query: 323 NKPFMGR----FYEWEP-FAEVKGNRKCELNCQAMGYRFYVRQAEKVIDGTPCDQNGTAI 377
+ F EW P +A V C+L C+A G +YV + KV DGT C ++
Sbjct: 638 GYQSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDGTECRLYSNSV 697
Query: 378 CVSGQCKSIGCDDYLGSDKVVDKCGVCGGDNTGCQVVSGVFKHALTSLGYHRVVEIPEGA 437
CV G+C GCD +GS DKCGVCGGDN+ C + G F S GY VV IPEGA
Sbjct: 698 CVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNK--KSKGYTDVVRIPEGA 755
Query: 438 TKINITEMYKSNN-----YLALRSRSGRSIINGNWAIDRPGK-YEGGGTMFTYKRPNEIS 491
T I + + + YLAL+ ++G +ING + I + GT+ Y
Sbjct: 756 THIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETIIDINGTVMNYS-----G 810
Query: 492 STAGESFL---AEGPTNEILDVYMIHQQPNPGVHYEYVIMGTNAISPQV 537
+ + FL T EIL V ++ P + Y +P+V
Sbjct: 811 WSHRDDFLHGMGYSATKEILIVQILATDPTKPLDVRYSFFVPKKSTPKV 859
Score = 43.9 bits (102), Expect = 8e-04
Identities = 43/160 (26%), Positives = 59/160 (36%), Gaps = 36/160 (22%)
Query: 774 EECNMKLRPNDIENCDMGPCAKSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEG 833
++CN+ P M CA+ W A VR +VC+T + ++
Sbjct: 495 QQCNLTFGPEYSVCPGMDVCARLWC-------------AVVRQGQMVCLTKKLPAVEGTP 541
Query: 834 CGNNRPAEATPCDNGPCTGKVE-----------WFA-GSWSQCSIECGSGTQQREVIC-- 879
CG R C G C K + W + GSW QCS CG G Q C
Sbjct: 542 CGKGRI-----CLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNN 596
Query: 880 --VRKNAD--TFEVLDPSECSFLEKPPSQQSCHLKPCGAK 915
R N T + CS + PP+ +S + C AK
Sbjct: 597 PAPRNNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAK 636
Score = 43.1 bits (100), Expect = 0.001
Identities = 16/27 (59%), Positives = 17/27 (62%)
Query: 54 GVWGAWGPWSACSRSCSGGVMEQTRPC 80
G WG+WG W CSRSC GGV R C
Sbjct: 568 GNWGSWGSWGQCSRSCGGGVQFAYRHC 594
Score = 36.6 bits (83), Expect = 0.12
Identities = 14/53 (26%), Positives = 25/53 (47%)
Query: 915 KWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERESCNPQDC 967
+W + W CS++C G+ R V+C + L+ C +P + C + C
Sbjct: 878 QWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
Score = 36.6 bits (83), Expect = 0.12
Identities = 20/57 (35%), Positives = 24/57 (42%), Gaps = 5/57 (8%)
Query: 680 WDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKIC 736
W G W CS+TC G R V C+ NR L C ++P C LK C
Sbjct: 879 WVTGPWLACSRTCDTGWHTRTVQCQD--GNRKLA---KGCPLSQRPSAFKQCLLKKC 930
Score = 36.2 bits (82), Expect = 0.16
Identities = 19/65 (29%), Positives = 26/65 (40%), Gaps = 5/65 (7%)
Query: 848 GPCTGKVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSC 907
G T + +W G W CS C +G R V C N C ++P + + C
Sbjct: 871 GSHTSQPQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKL-----AKGCPLSQRPSAFKQC 925
Query: 908 HLKPC 912
LK C
Sbjct: 926 LLKKC 930
Score = 32.3 bits (72), Expect = 2.3
Identities = 17/40 (42%), Positives = 21/40 (52%), Gaps = 4/40 (10%)
Query: 60 GPWSACSRSCSGGVMEQTRPCLPRSYRLRGG----QRPGA 95
GPW ACSR+C G +T C + +L G QRP A
Sbjct: 882 GPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSA 921
Score = 30.4 bits (67), Expect = 8.9
Identities = 15/49 (30%), Positives = 23/49 (46%), Gaps = 2/49 (4%)
Query: 745 WTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCDMGPC 793
W +CS C G TR V+C G+ + C + RP+ + C + C
Sbjct: 884 WLACSRTCDTGWHTRTVQCQD--GNRKLAKGCPLSQRPSAFKQCLLKKC 930
>gi|157427675 ADAM metallopeptidase with thrombospondin type 1
motif, 4 preproprotein [Homo sapiens]
Length = 837
Score = 134 bits (336), Expect = 6e-31
Identities = 90/298 (30%), Positives = 142/298 (47%), Gaps = 26/298 (8%)
Query: 264 ETSNNHGVGTHGATQSFSQPA-RSTAISCIGAYRQYKLCNTNVCPESSR-SIREVQCASY 321
+ S G G +++ ++P R+ C G +++ CNT CP S + RE QCA+Y
Sbjct: 531 DCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSALTFREEQCAAY 590
Query: 322 NNKPFMGRFY----EWEP-FAEVKGNRKCELNCQAMGYRFYVRQAEKVIDGTPCDQNGTA 376
N++ + + + +W P + V +C+L CQA +Y +V+DGTPC + ++
Sbjct: 591 NHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVVDGTPCSPDSSS 650
Query: 377 ICVSGQCKSIGCDDYLGSDKVVDKCGVCGGDNTGCQVVSGVFKHALTSLGYHRVVEIPEG 436
+CV G+C GCD +GS K DKC VCGGD +GC SG F+ GY+ VV IP G
Sbjct: 651 VCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRK--FRYGYNNVVTIPAG 708
Query: 437 ATKINITEMYKSNN---YLALRSRSGRSIINGNWAIDRPGKYE---GGGTMFTYKRPNEI 490
AT I + + + YLAL+ G +NG + + P + G Y
Sbjct: 709 ATHILVRQQGNPGHRSIYLALKLPDGSYALNGEYTL-MPSPTDVVLPGAVSLRYSG---- 763
Query: 491 SSTAGESFLAEGPTNE--ILDVYMIHQQPNPGVHYEYVIMGTNAISPQVPP----HRR 542
++ A E+ GP + L V + + + Y + + +P+ P HRR
Sbjct: 764 ATAASETLSGHGPLAQPLTLQVLVAGNPQDTRLRYSFFVPRPTPSTPRPTPQDWLHRR 821
Score = 45.8 bits (107), Expect = 2e-04
Identities = 16/27 (59%), Positives = 18/27 (66%)
Query: 54 GVWGAWGPWSACSRSCSGGVMEQTRPC 80
G WG WGPW CSR+C GGV +R C
Sbjct: 521 GGWGPWGPWGDCSRTCGGGVQFSSRDC 547
Score = 32.0 bits (71), Expect = 3.0
Identities = 34/125 (27%), Positives = 39/125 (31%), Gaps = 37/125 (29%)
Query: 773 DEECNMKLRPNDIENCDM--GPCAKSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLP 830
D +C + P D +C PCA W CS +C T H
Sbjct: 446 DRQCQLTFGP-DSRHCPQLPPPCAALW--------CSGHLNG-----HAMCQTKHSPWAD 491
Query: 831 LEGCGNNRPAEATPCDNGPCT--------------GKVEWFAGSWSQCSIECGSGTQQRE 876
CG PA+A C G C G W G W CS CG G Q
Sbjct: 492 GTPCG---PAQA--CMGGRCLHMDQLQDFNIPQAGGWGPW--GPWGDCSRTCGGGVQFSS 544
Query: 877 VICVR 881
C R
Sbjct: 545 RDCTR 549
>gi|21265043 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 3 preproprotein [Homo sapiens]
Length = 1340
Score = 130 bits (326), Expect = 8e-30
Identities = 95/387 (24%), Positives = 157/387 (40%), Gaps = 57/387 (14%)
Query: 629 CSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPCPAFWDIGEWSEC 688
CS +CG G ++ + C+ ++ E C S +P E C + PCP +W +G++ C
Sbjct: 664 CSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPC 723
Query: 689 SKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQ-HLEKPETT-STCQLKIC-SEWQIRTDW 745
S +CG G++ R V C + + T+ P RC+ ++P TC + C + W++ ++
Sbjct: 724 SASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEV-SEP 782
Query: 746 TSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDI-------ENCDMGPCAKSW- 797
+SC+ G G + CV D E + P + E C C W
Sbjct: 783 SSCTSAGGAGLALENETCVPG----ADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWG 838
Query: 798 --------------------------FLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPL 831
T + CS CG G+ +CM + + +P+
Sbjct: 839 HLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSAL-RVPV 897
Query: 832 E----GCGNNRPAEATPCDNGPCTGKVEWFAGSWSQCSIECGSGTQQREVICVRKNA--D 885
+ G + + C PC + ++ + CS+ CG G +R + C R + D
Sbjct: 898 QEELCGLASKPGSRREVCQAVPCPARWQY---KLAACSVSCGRGVVRRILYCARAHGEDD 954
Query: 886 TFEVLDPSECSFLEKPPSQQSCHLKPCGAKWFSTEWSMCSKSCQGGFRVREVRCLSDDM- 944
E+L ++C L +P Q++C L+PC +W CS SC G R V C+ D
Sbjct: 955 GEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQG 1014
Query: 945 ----TLSNLCDPQLKPEERESCNPQDC 967
C ++PE C DC
Sbjct: 1015 QDVEVDEAACAALVRPEASVPCLIADC 1041
Score = 120 bits (300), Expect = 8e-27
Identities = 108/383 (28%), Positives = 143/383 (37%), Gaps = 48/383 (12%)
Query: 629 CSTTCGKGSQYPIFRCVHR--STHEEAPESYCDS-SMKPTPEEEPCNIFPCPAFWDIGEW 685
CS +CG G + RCV S + P + C + + +P E CN PCPA W++ E
Sbjct: 723 CSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEP 782
Query: 686 SECSKTCGLGMQHRQVLCRQVYANRSLTVQ------------PYRCQHLEKP------ET 727
S C+ G G+ C V P C + P +
Sbjct: 783 SSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDA 842
Query: 728 TSTCQLKICSEW-QIRTD------WT----SCSVPCGVGQRTRDVKCVSNIGDV-VDDEE 775
TS + K S W IRT WT SCSV CG G C+ + V V +E
Sbjct: 843 TSAGE-KAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEEL 901
Query: 776 CNMKLRPNDI-ENCDMGPCAKSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSS------ 828
C + +P E C PC W CS CG GV R + C H
Sbjct: 902 CGLASKPGSRREVCQAVPCPARWQYK--LAACSVSCGRGVVRRILYCARAHGEDDGEEIL 959
Query: 829 LPLEGCGNNRPAEATPCDNGPCTGKVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFE 888
L + G RP C PC + W S CS CG GT +R V CV+ +
Sbjct: 960 LDTQCQGLPRPEPQEACSLEPCPPR--WKVMSLGPCSASCGLGTARRSVACVQLDQGQDV 1017
Query: 889 VLDPSECSFLEKPPSQQSCHLKPCGAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTL-- 946
+D + C+ L +P + C + C +W W CS SC G + R CL
Sbjct: 1018 EVDEAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPV 1077
Query: 947 -SNLCDPQLKPEERESCNPQDCV 968
++ C KP C CV
Sbjct: 1078 PADFCQHLPKPVTVRGCWAGPCV 1100
Score = 112 bits (280), Expect = 2e-24
Identities = 70/233 (30%), Positives = 104/233 (44%), Gaps = 11/233 (4%)
Query: 629 CSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPCPAFWDIGEWSEC 688
CS +CG+G F C+ + E C + KP E C PCPA W + + C
Sbjct: 873 CSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQY-KLAAC 931
Query: 689 SKTCGLGMQHRQVLCRQVYA--NRSLTVQPYRCQHLEKPETTSTCQLKIC-SEWQIRTDW 745
S +CG G+ R + C + + + + +CQ L +PE C L+ C W++ +
Sbjct: 932 SVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMS-L 990
Query: 746 TSCSVPCGVGQRTRDVKCV--SNIGDV-VDDEECNMKLRPNDIENCDMGPCAKSWFLTEW 802
CS CG+G R V CV DV VD+ C +RP C + C W + W
Sbjct: 991 GPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGTW 1050
Query: 803 SERCSAECGAGVRTRSVVCMTNHVSS-LPLEGCGN-NRPAEATPCDNGPCTGK 853
E CS CG G++ R C+ + +P + C + +P C GPC G+
Sbjct: 1051 ME-CSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQ 1102
Score = 110 bits (274), Expect = 9e-24
Identities = 95/345 (27%), Positives = 129/345 (37%), Gaps = 55/345 (15%)
Query: 608 PAPQPPRRSRDHNWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSM-KPTP 666
P P P R W+ + C++ G G CV + EAP + S+ + P
Sbjct: 770 PQPCPAR------WEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLP 823
Query: 667 EEEPCNIFPCPAFW------DIGE------------------WS----ECSKTCGLGMQH 698
EPC CP W GE W+ CS +CG G+
Sbjct: 824 APEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLME 883
Query: 699 RQVLCRQVYANRSLTVQPYRCQHLEKP-ETTSTCQLKIC-SEWQIRTDWTSCSVPCGVGQ 756
+ LC + + VQ C KP CQ C + WQ + +CSV CG G
Sbjct: 884 LRFLCMD--SALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKL--AACSVSCGRGV 939
Query: 757 RTRDVKCVSNIG-----DVVDDEECNMKLRPNDIENCDMGPCAKSWFLTEWSERCSAECG 811
R + C G +++ D +C RP E C + PC W + CSA CG
Sbjct: 940 VRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGP-CSASCG 998
Query: 812 AGVRTRSVVCMT----NHVSSLPLEGCGNNRPAEATPCDNGPCTGKVEWFAGSWSQCSIE 867
G RSV C+ V RP + PC CT W G+W +CS+
Sbjct: 999 LGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCT--YRWHVGTWMECSVS 1056
Query: 868 CGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPC 912
CG G Q+R C+ A + C L KP + + C PC
Sbjct: 1057 CGDGIQRRRDTCLGPQAQA--PVPADFCQHLPKPVTVRGCWAGPC 1099
Score = 99.8 bits (247), Expect = 1e-20
Identities = 58/192 (30%), Positives = 93/192 (48%), Gaps = 14/192 (7%)
Query: 290 SCIGAYRQYKLCNTNVCPESSRSIREVQCASYNNKPFMGR-----FYEW-EPFAEVKGNR 343
+C+GA Q ++CNT C ++ QCA + +P FY W +G+
Sbjct: 391 ACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDA 450
Query: 344 KCELNCQAMGYRFYVRQAEKVIDGTPCDQNGT------AICVSGQCKSIGCDDYLGSDKV 397
C C+A+G F +++ + +DGT C +G ++CVSG C++ GCD + S +V
Sbjct: 451 LCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQV 510
Query: 398 VDKCGVCGGDNTGCQVVSGVFKHALTSLGYHRVVEIPEGATKINITEMYKSNNYLALRSR 457
D+C VCGGDN+ C G F A + Y + + T + I +LA+R
Sbjct: 511 WDRCQVCGGDNSTCSPRKGSFT-AGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRI- 568
Query: 458 SGRSIINGNWAI 469
GR ++ G +I
Sbjct: 569 GGRYVVAGKMSI 580
Score = 85.1 bits (209), Expect = 3e-16
Identities = 78/326 (23%), Positives = 127/326 (38%), Gaps = 50/326 (15%)
Query: 688 CSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPET-TSTCQLKICSEWQIRTDWT 746
CS +CG G++ C R V+ +CQ ++P C L+ C + D+
Sbjct: 664 CSVSCGAGLRWVNYSCLD--QARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFG 721
Query: 747 SCSVPCGVGQRTRDVKCVSNIGDVVDD---EECNMKLRPNDI--ENCDMGPCAKSWFLTE 801
CS CG G R R V+CV G ++ C + + E C+ PC W ++E
Sbjct: 722 PCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSE 781
Query: 802 WSERCSAECGAGVRTRSVVCM--TNHVSSLPLEGCGN--NRPAEATPCDNGPC------- 850
S C++ GAG+ + C+ + + + EG G+ + PC C
Sbjct: 782 PSS-CTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHL 840
Query: 851 --TGKVEWFAGSWSQ-----------------CSIECGSGTQQREVICVRKNADTFEVLD 891
T E W CS+ CG G + +C+ ++ +
Sbjct: 841 DATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCM--DSALRVPVQ 898
Query: 892 PSECSFLEKPPSQQS-CHLKPCGAKWFSTEWSMCSKSCQGGFRVREVRCL-------SDD 943
C KP S++ C PC A+W + + CS SC G R + C ++
Sbjct: 899 EELCGLASKPGSRREVCQAVPCPARW-QYKLAACSVSCGRGVVRRILYCARAHGEDDGEE 957
Query: 944 MTLSNLCDPQLKPEERESCNPQDCVP 969
+ L C +PE +E+C+ + C P
Sbjct: 958 ILLDTQCQGLPRPEPQEACSLEPCPP 983
Score = 72.0 bits (175), Expect = 3e-12
Identities = 58/203 (28%), Positives = 77/203 (37%), Gaps = 21/203 (10%)
Query: 610 PQPPRRSRDHNWKQLGTTECSTTCGKGSQYPIFRCVH--RSTHEEAPESYCDSSMKPTPE 667
P PPR WK + CS +CG G+ CV + E E+ C + ++P
Sbjct: 980 PCPPR------WKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRP-EA 1032
Query: 668 EEPCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPET 727
PC I C W +G W ECS +CG G+Q R+ C A + CQHL KP T
Sbjct: 1033 SVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPAD--FCQHLPKPVT 1090
Query: 728 TSTCQLKIC----SEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPN 783
C C + + + T G GQ V +G+VV L
Sbjct: 1091 VRGCWAGPCVGQGACGRQHLEPTGTIDMRGPGQADCAVAIGRPLGEVVTLRVLESSL--- 1147
Query: 784 DIENCDMGPCAKSWFLTEWSERC 806
NC G W W + C
Sbjct: 1148 ---NCSAGDMLLLWGRLTWRKMC 1167
Score = 68.6 bits (166), Expect = 3e-11
Identities = 41/152 (26%), Positives = 66/152 (43%), Gaps = 9/152 (5%)
Query: 795 KSWFLTEWSERCSAECGAGVRTRSVVCMTNH----VSSLPLEGCGNNRPAEATPCDNGPC 850
++W CS CGAG+R + C+ V ++ +G PA C PC
Sbjct: 653 QAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVETVQCQG-SQQPPAWPEACVLEPC 711
Query: 851 TGKVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPP--SQQSCH 908
W G + CS CG G ++R V CV + L P+ C + P + ++C+
Sbjct: 712 PPY--WAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCN 769
Query: 909 LKPCGAKWFSTEWSMCSKSCQGGFRVREVRCL 940
+PC A+W +E S C+ + G + C+
Sbjct: 770 PQPCPARWEVSEPSSCTSAGGAGLALENETCV 801
Score = 42.7 bits (99), Expect = 0.002
Identities = 16/27 (59%), Positives = 19/27 (70%)
Query: 54 GVWGAWGPWSACSRSCSGGVMEQTRPC 80
G W +WGP S CSRSC GGV+ + R C
Sbjct: 354 GRWSSWGPRSPCSRSCGGGVVTRRRQC 380
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.433
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,325,325
Number of Sequences: 37866
Number of extensions: 2714669
Number of successful extensions: 12140
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 64
Number of HSP's successfully gapped in prelim test: 88
Number of HSP's that attempted gapping in prelim test: 9712
Number of HSP's gapped (non-prelim): 1157
length of query: 1018
length of database: 18,247,518
effective HSP length: 112
effective length of query: 906
effective length of database: 14,006,526
effective search space: 12689912556
effective search space used: 12689912556
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.