Search of human proteins with 93277096

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|93277096 limbin [Homo sapiens]
         (1308 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|93277096 limbin [Homo sapiens]                                    2553   0.0  
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     81   7e-15
gi|148746195 trichohyalin [Homo sapiens]                               76   2e-13
gi|87298937 centrosomal protein 110kDa [Homo sapiens]                  75   5e-13
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        74   9e-13
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        74   9e-13
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         74   9e-13
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         74   9e-13
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         74   9e-13
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         74   9e-13
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         74   9e-13
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         74   9e-13
gi|21735548 centrosomal protein 2 [Homo sapiens]                       74   1e-12
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    74   1e-12
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    74   1e-12
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...    74   1e-12
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...    74   1e-12
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]    73   2e-12
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    72   3e-12
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa...    72   5e-12
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ...    71   6e-12
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...    71   8e-12
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]     70   1e-11
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo...    70   1e-11
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo...    70   1e-11
gi|156104908 myosin heavy chain 6 [Homo sapiens]                       69   3e-11
gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens]    69   3e-11
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]         68   5e-11
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...    67   1e-10
gi|115648142 centrosomal protein 164kDa [Homo sapiens]                 67   1e-10

>gi|93277096 limbin [Homo sapiens]
          Length = 1308

 Score = 2553 bits (6616), Expect = 0.0
 Identities = 1308/1308 (100%), Positives = 1308/1308 (100%)

Query: 1    MDPSGSRGRPTWVLAGGLLAVALALGGRGCLGASSRPRWRPLGAQPPRDPQVAPRSGPGL 60
            MDPSGSRGRPTWVLAGGLLAVALALGGRGCLGASSRPRWRPLGAQPPRDPQVAPRSGPGL
Sbjct: 1    MDPSGSRGRPTWVLAGGLLAVALALGGRGCLGASSRPRWRPLGAQPPRDPQVAPRSGPGL 60

Query: 61   RIPPGRSGAGPESSTQDLPCMIWPKVECCHFKTAVEAPLGMKLDKKMEVFIPLSTSAASS 120
            RIPPGRSGAGPESSTQDLPCMIWPKVECCHFKTAVEAPLGMKLDKKMEVFIPLSTSAASS
Sbjct: 61   RIPPGRSGAGPESSTQDLPCMIWPKVECCHFKTAVEAPLGMKLDKKMEVFIPLSTSAASS 120

Query: 121  GPWAHSLFAFIPSWPKKNLFKRESPITHRLYGDISREVQGTSENGVIFQKCALVSGSSEA 180
            GPWAHSLFAFIPSWPKKNLFKRESPITHRLYGDISREVQGTSENGVIFQKCALVSGSSEA
Sbjct: 121  GPWAHSLFAFIPSWPKKNLFKRESPITHRLYGDISREVQGTSENGVIFQKCALVSGSSEA 180

Query: 181  QTARIWLLVNNTKTTSSANLSELLLLDSIAGLTIWDSVGNRTSEGFQAFSKKFLQVGDAF 240
            QTARIWLLVNNTKTTSSANLSELLLLDSIAGLTIWDSVGNRTSEGFQAFSKKFLQVGDAF
Sbjct: 181  QTARIWLLVNNTKTTSSANLSELLLLDSIAGLTIWDSVGNRTSEGFQAFSKKFLQVGDAF 240

Query: 241  AVSYAATLQAGDLGNGESLKLPAQLTFQSSSRNRTQLKVLFSITAEENVTVLPHHGLHAA 300
            AVSYAATLQAGDLGNGESLKLPAQLTFQSSSRNRTQLKVLFSITAEENVTVLPHHGLHAA
Sbjct: 241  AVSYAATLQAGDLGNGESLKLPAQLTFQSSSRNRTQLKVLFSITAEENVTVLPHHGLHAA 300

Query: 301  GFFIAFLLSLVLTWAALFLMVRYQCLKGNMLTRHRVWQYESKLEPLPFTSADGVNEDLSL 360
            GFFIAFLLSLVLTWAALFLMVRYQCLKGNMLTRHRVWQYESKLEPLPFTSADGVNEDLSL
Sbjct: 301  GFFIAFLLSLVLTWAALFLMVRYQCLKGNMLTRHRVWQYESKLEPLPFTSADGVNEDLSL 360

Query: 361  NDQMIDILSSEDPGSMLQALEELEIATLNRADADLEACRTQISKDIIALLLKNLTSSGHL 420
            NDQMIDILSSEDPGSMLQALEELEIATLNRADADLEACRTQISKDIIALLLKNLTSSGHL
Sbjct: 361  NDQMIDILSSEDPGSMLQALEELEIATLNRADADLEACRTQISKDIIALLLKNLTSSGHL 420

Query: 421  SPQVERKMSAVFKKQFLLLENEIQEEYDRKMVALTAECDLETRKKMENQYQREMMAMEEA 480
            SPQVERKMSAVFKKQFLLLENEIQEEYDRKMVALTAECDLETRKKMENQYQREMMAMEEA
Sbjct: 421  SPQVERKMSAVFKKQFLLLENEIQEEYDRKMVALTAECDLETRKKMENQYQREMMAMEEA 480

Query: 481  EELLKRAGERSAVECSNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVFQRNELHSI 540
            EELLKRAGERSAVECSNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVFQRNELHSI
Sbjct: 481  EELLKRAGERSAVECSNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVFQRNELHSI 540

Query: 541  FFTQIKSAIFKGELKPEAAKMLLQNYSKIQENVEELMDFFQASKRYHLSKRFGHREYLVQ 600
            FFTQIKSAIFKGELKPEAAKMLLQNYSKIQENVEELMDFFQASKRYHLSKRFGHREYLVQ
Sbjct: 541  FFTQIKSAIFKGELKPEAAKMLLQNYSKIQENVEELMDFFQASKRYHLSKRFGHREYLVQ 600

Query: 601  NLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDL 660
            NLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDL
Sbjct: 601  NLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDL 660

Query: 661  KQEKKKLHQKLITKRRRELLQKHREQRREQASVGEAFRTVEDAGQYLHQKRSLMEEHGAT 720
            KQEKKKLHQKLITKRRRELLQKHREQRREQASVGEAFRTVEDAGQYLHQKRSLMEEHGAT
Sbjct: 661  KQEKKKLHQKLITKRRRELLQKHREQRREQASVGEAFRTVEDAGQYLHQKRSLMEEHGAT 720

Query: 721  LEELQERLDQAALDDLRTLTLSLFEKATDELRRLQNSAMTQELLKRGVPWLFLQQILEEH 780
            LEELQERLDQAALDDLRTLTLSLFEKATDELRRLQNSAMTQELLKRGVPWLFLQQILEEH
Sbjct: 721  LEELQERLDQAALDDLRTLTLSLFEKATDELRRLQNSAMTQELLKRGVPWLFLQQILEEH 780

Query: 781  GKEMAARAEQLEGEERDRDQEGVQSVRQRLKDDAPEAVTEEQAELRRWEHLIFMKLCSSV 840
            GKEMAARAEQLEGEERDRDQEGVQSVRQRLKDDAPEAVTEEQAELRRWEHLIFMKLCSSV
Sbjct: 781  GKEMAARAEQLEGEERDRDQEGVQSVRQRLKDDAPEAVTEEQAELRRWEHLIFMKLCSSV 840

Query: 841  FSLSEEELLRMRQEVHGCFAQMDRSLALPKIRARVLLQQFQTAWREAEFVKLDQAVAAPE 900
            FSLSEEELLRMRQEVHGCFAQMDRSLALPKIRARVLLQQFQTAWREAEFVKLDQAVAAPE
Sbjct: 841  FSLSEEELLRMRQEVHGCFAQMDRSLALPKIRARVLLQQFQTAWREAEFVKLDQAVAAPE 900

Query: 901  LQQQSKVRKSRSKSKSKGELLKKCIEDKIHLCEEQASEDLVEKVRGELLRERVQRMEAQE 960
            LQQQSKVRKSRSKSKSKGELLKKCIEDKIHLCEEQASEDLVEKVRGELLRERVQRMEAQE
Sbjct: 901  LQQQSKVRKSRSKSKSKGELLKKCIEDKIHLCEEQASEDLVEKVRGELLRERVQRMEAQE 960

Query: 961  GGFAQSLVALQFQKASRVTETLSAYTALLSIQDLLLEELSASEMLTKSACTQILESHSRE 1020
            GGFAQSLVALQFQKASRVTETLSAYTALLSIQDLLLEELSASEMLTKSACTQILESHSRE
Sbjct: 961  GGFAQSLVALQFQKASRVTETLSAYTALLSIQDLLLEELSASEMLTKSACTQILESHSRE 1020

Query: 1021 LQELERKLEDQLVQQEAAQQQQALASWQQWVADGPGILNEPGEVDSERQVSTVLHQALSK 1080
            LQELERKLEDQLVQQEAAQQQQALASWQQWVADGPGILNEPGEVDSERQVSTVLHQALSK
Sbjct: 1021 LQELERKLEDQLVQQEAAQQQQALASWQQWVADGPGILNEPGEVDSERQVSTVLHQALSK 1080

Query: 1081 SQTLLEQHQQCLREEQQNSVVLEDLLENMEADTFATLCSQELRLASYLARMAMVPGATLR 1140
            SQTLLEQHQQCLREEQQNSVVLEDLLENMEADTFATLCSQELRLASYLARMAMVPGATLR
Sbjct: 1081 SQTLLEQHQQCLREEQQNSVVLEDLLENMEADTFATLCSQELRLASYLARMAMVPGATLR 1140

Query: 1141 RLLSVVLPTASQPQLLALLDSATERHVDHAAESDGGAEQADVGRRRKHQSWWQALDGKLR 1200
            RLLSVVLPTASQPQLLALLDSATERHVDHAAESDGGAEQADVGRRRKHQSWWQALDGKLR
Sbjct: 1141 RLLSVVLPTASQPQLLALLDSATERHVDHAAESDGGAEQADVGRRRKHQSWWQALDGKLR 1200

Query: 1201 GDLISRGLEKMLWARKRKQSILKKTCLPLRERMIFSGKGSWPHLSLEPIGELAPVPIVGA 1260
            GDLISRGLEKMLWARKRKQSILKKTCLPLRERMIFSGKGSWPHLSLEPIGELAPVPIVGA
Sbjct: 1201 GDLISRGLEKMLWARKRKQSILKKTCLPLRERMIFSGKGSWPHLSLEPIGELAPVPIVGA 1260

Query: 1261 ETIDLLNTGEKLFIFRNPKEPEISLHVPPRKKKNFLNAKKAMRALGMD 1308
            ETIDLLNTGEKLFIFRNPKEPEISLHVPPRKKKNFLNAKKAMRALGMD
Sbjct: 1261 ETIDLLNTGEKLFIFRNPKEPEISLHVPPRKKKNFLNAKKAMRALGMD 1308


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 80.9 bits (198), Expect = 7e-15
 Identities = 166/803 (20%), Positives = 330/803 (41%), Gaps = 121/803 (15%)

Query: 359  SLNDQMIDILSSEDPGSMLQALEELEIATLNRADADLEACRTQISKDIIALLLKNLTSSG 418
            +L  ++ D L S      L++  E E+  L +    LE         I  +  K+  +  
Sbjct: 1143 ALKTELEDTLDSTAAQQELRSKREQEVNILKKT---LEEEAKTHEAQIQEMRQKHSQAVE 1199

Query: 419  HLSPQVE--RKMSAVFKKQFLLLENEIQEEYDRKMVALTAECDLE-TRKKMENQYQREMM 475
             L+ Q+E  +++ A  +K    LENE  E  +   V L  + D E  RKK+E Q Q   +
Sbjct: 1200 ELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQV 1259

Query: 476  AMEEAEELLKRAGER-----------------SAVECSNLLRTLHGLEQEHLRKSLALQQ 518
               E E +     ++                 S  + S L +    LE + L+ +  L Q
Sbjct: 1260 KFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQ-LQDTQELLQ 1318

Query: 519  EEDFAKAHRQLAVFQRNELHSIFFTQIKSAIFKGELKPEAAKMLLQNYSKI---QENVEE 575
            EE+  K      + Q  +  + F  Q++    + E K    K +   ++++   ++ +E+
Sbjct: 1319 EENRQKLSLSTKLKQVEDEKNSFREQLEE---EEEAKHNLEKQIATLHAQVADMKKKMED 1375

Query: 576  LMDFFQASKRYH---------LSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQK 626
             +   + ++            LS+R   +      L+ ++TR+Q  L      L H   +
Sbjct: 1376 SVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDH---Q 1432

Query: 627  HERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLKQ-EKKKLHQKLITKRRRELLQKHRE 685
             + A  L++ Q +     A+ +  S K   + D  + E ++   K ++  R   L++  E
Sbjct: 1433 RQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARA--LEEAME 1490

Query: 686  QRREQASVGEAFRTV--------EDAGQYLHQ----KRSL---MEEHGATLEELQERLDQ 730
            Q+ E   + + FRT         +D G+ +H+    KR+L   +EE    LEEL++ L Q
Sbjct: 1491 QKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDEL-Q 1549

Query: 731  AALDDLRTLTLSLFEKATDELRRLQNSAMTQELLKRGVPWLFLQQILEEHGKEMAARAEQ 790
            A  D    L ++L        R LQ                   +  EE  K++  +  +
Sbjct: 1550 ATEDAKLRLEVNLQAMKAQFERDLQGR----------------DEQSEEKKKQLVRQVRE 1593

Query: 791  LEGEERDRDQEGVQSV--RQRLKDDAPEAVTEEQAELRRWEHLIFMKLCSSVFSLSEEEL 848
            +E E  D  ++   +V  R++L+ D  +      +  +  +  I             ++L
Sbjct: 1594 MEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAI-------------KQL 1640

Query: 849  LRMRQEVHGCFAQMDRSLAL-PKIRARVLLQQFQTAWREAEFVKLDQAVAAPEL------ 901
             +++ ++  C  ++D + A   +I A+    + +    EAE ++L + +AA E       
Sbjct: 1641 RKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQ 1700

Query: 902  QQQSKVRKSRSKSKSKGELL---KKCIEDKIHLCEEQASEDLVEKVRGELLRERVQRMEA 958
            Q++ ++    + S  KG L    K+ +E +I   EE+  E   E+   EL+ +R+++   
Sbjct: 1701 QERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEE---EQGNTELINDRLKKANL 1757

Query: 959  Q--EGGFAQSLVALQFQKASRVTETLSAYTALLSIQDLLLEELSASEMLTKSACTQILES 1016
            Q  +     +L     QK     + L      L ++   L+E+  +      A    LE+
Sbjct: 1758 QIDQINTDLNLERSHAQKNENARQQLERQNKELKVK---LQEMEGTVKSKYKASITALEA 1814

Query: 1017 HSRELQELERKLEDQLVQQEAAQQQQALASWQQWVADGPGILNEPGEVDSERQVSTVLHQ 1076
               ++ +LE +L+++  +++AA +Q      +        + +   +VD ER+ +     
Sbjct: 1815 ---KIAQLEEQLDNETKERQAACKQVRRTEKK--------LKDVLLQVDDERRNAEQYKD 1863

Query: 1077 ALSKSQTLLEQHQQCLREEQQNS 1099
               K+ T L+Q ++ L E ++ +
Sbjct: 1864 QADKASTRLKQLKRQLEEAEEEA 1886



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 152/770 (19%), Positives = 327/770 (42%), Gaps = 138/770 (17%)

Query: 409  LLLKNLTSSGHLSPQVERKMSAVFKKQFLLLENEIQEEYDRKMVALTAECDLETRKKMEN 468
            L L+ +T+   L    E ++    +   L  E ++ E+   +      E + +++   + 
Sbjct: 962  LQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKL 1021

Query: 469  QYQREMMAMEEAEELLKRAGERSAVECSNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQ 528
            + + E M + + EE L+R  E+   E     R L G +   L   +A  Q +  A+   Q
Sbjct: 1022 KNKHEAM-ITDLEERLRRE-EKQRQELEKTRRKLEG-DSTDLSDQIAELQAQ-IAELKMQ 1077

Query: 529  LAVFQRNELHSIFFTQIKSAIFKGELKPEAAKMLLQNYSKIQENVEELMDFFQASKRYHL 588
            LA  +          ++++A+ + E +     M L+   +++  + EL +  + S+R   
Sbjct: 1078 LAKKEE---------ELQAALARVEEEAAQKNMALKKIRELESQISELQEDLE-SERASR 1127

Query: 589  SKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTE 648
            +K    +  L + L++ +T ++  L + AAQ                   + L  + + E
Sbjct: 1128 NKAEKQKRDLGEELEALKTELEDTLDSTAAQ-------------------QELRSKREQE 1168

Query: 649  VFSIKQKLDNDLK------QEKKKLHQKLITKRRRELLQKHREQRREQASVGEAFRTVE- 701
            V  +K+ L+ + K      QE ++ H + +     EL ++  + +R +A++ +A +T+E 
Sbjct: 1169 VNILKKTLEEEAKTHEAQIQEMRQKHSQAV----EELAEQLEQTKRVKANLEKAKQTLEN 1224

Query: 702  DAGQYLHQKRSLMEEHG----------ATLEELQERLDQAALDDLRTLTLSLFEKATDEL 751
            + G+  ++ + L++  G          A L+ELQ + ++   + +RT       K   EL
Sbjct: 1225 ERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEG--ERVRTELADKVTKLQVEL 1282

Query: 752  RRL---------QNSAMTQELLKRGVPWLFLQQILEEHGKEMAARAEQLEGEERDRDQEG 802
              +         ++S +T++           Q++L+E  ++  + + +L+  E +++   
Sbjct: 1283 DNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKN--- 1339

Query: 803  VQSVRQRLKDD--APEAVTEEQAELRRWEHLIFMKLCSSVFSL--SEEELLRMRQEVHGC 858
              S R++L+++  A   + ++ A L      +  K+  SV  L  +EE   ++++++ G 
Sbjct: 1340 --SFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGL 1397

Query: 859  FAQMDRSLA----LPKIRARV----------LLQQFQTAWR-EAEFVKLDQAVAAPEL-- 901
              + +  +A    L K + R+          L  Q Q+A   E +  K DQ +A  +   
Sbjct: 1398 SQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTIS 1457

Query: 902  --------QQQSKVRKSRSKSKSKGELLKKCIEDKIHLC-----------EEQASEDLVE 942
                    + +++ R+  +K+ S    L++ +E K  L            +  +S+D V 
Sbjct: 1458 AKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVG 1517

Query: 943  KVRGEL------LRERVQRMEAQEGGFAQSLVALQFQKASRVTETLSAYTALLSIQDLLL 996
            K   EL      L ++V+ M+ Q       L A +  K  R+   L A  A         
Sbjct: 1518 KSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKL-RLEVNLQAMKAQFE------ 1570

Query: 997  EELSASEMLTKSACTQILESHSRELQELERKLEDQLVQQEAAQQQQALASWQQWVADGPG 1056
             +L   +  ++    Q++    R+++E+E +LED     E  Q+  A+A+ ++   D   
Sbjct: 1571 RDLQGRDEQSEEKKKQLV----RQVREMEAELED-----ERKQRSMAVAARKKLEMD--- 1618

Query: 1057 ILNEPGEVDSERQVSTVLHQALSKSQTLLEQHQQCLREEQQNSVVLEDLL 1106
            + +    +DS  +      +A+ + + L  Q + C+RE        E++L
Sbjct: 1619 LKDLEAHIDSANKNR---DEAIKQLRKLQAQMKDCMRELDDTRASREEIL 1665



 Score = 52.0 bits (123), Expect = 4e-06
 Identities = 126/638 (19%), Positives = 252/638 (39%), Gaps = 90/638 (14%)

Query: 340  ESKLEPLPFTSADGVNEDLSLNDQMIDILSSEDPGSMLQALEELE---------IATLNR 390
            ES+L+       +   + LSL+ ++  +   ++  S  + LEE E         IATL+ 
Sbjct: 1307 ESQLQDTQELLQEENRQKLSLSTKLKQV--EDEKNSFREQLEEEEEAKHNLEKQIATLHA 1364

Query: 391  ADADLE-------ACRTQISKDIIALLLKNLTSSGHLSPQVERKMSAVFKKQFLLLENEI 443
              AD++        C  + ++++   L K+L     LS + E K++A  K +    +  +
Sbjct: 1365 QVADMKKKMEDSVGC-LETAEEVKRKLQKDLEG---LSQRHEEKVAAYDKLE--KTKTRL 1418

Query: 444  QEEYDRKMVALTAE----CDLETRKKMENQYQREMMAMEEAEELLKRAGERSAVECSNLL 499
            Q+E D  +V L  +    C+LE ++K  +Q     +  EE     K A ER   E     
Sbjct: 1419 QQELDDLLVDLDHQRQSACNLEKKQKKFDQ-----LLAEEKTISAKYAEERDRAEAEARE 1473

Query: 500  RTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVFQRNELHSIFFTQIKSAIFKGELKPEAA 559
            +    L      +  A++Q+ +  + ++Q     R E+  +  +  K  + K   + E +
Sbjct: 1474 KETKALSLARALEE-AMEQKAELERLNKQF----RTEMEDLMSS--KDDVGKSVHELEKS 1526

Query: 560  KMLL-QNYSKIQENVEELMDFFQASKRYHLS--------KRFGHREYLVQNLQSSETRVQ 610
            K  L Q   +++  +EEL D  QA++   L         K    R+   ++ QS E + Q
Sbjct: 1527 KRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQ 1586

Query: 611  GLLSTAAAQLTHLIQKHERA-GYLDEDQMEMLLERAQTEVFSIKQKLDNDLKQEKKKLHQ 669
             +      +     ++ +R+       ++EM L+  +  + S  +  D  +KQ +K   Q
Sbjct: 1587 LVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQ 1646

Query: 670  KLITKR--------RRELLQKHREQRREQASV-GEAFRTVEDAGQYLHQKRSLMEEHGAT 720
                 R        R E+L + +E  ++  S+  E  +  E+       KR   +E    
Sbjct: 1647 MKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDEL 1706

Query: 721  LEELQERLDQAAL--DDLRTLTLSLFEKATDELRRLQNSAMTQELLKRGVPWLFLQQI-- 776
             +E+     + AL  ++ R L   + +   +      N+ +  + LK+    L + QI  
Sbjct: 1707 ADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKAN--LQIDQINT 1764

Query: 777  ------------------LEEHGKEMAARAEQLEGEERDRDQEGVQSVRQRLKDDAPEAV 818
                              LE   KE+  + +++EG  + + +  + ++  ++      A 
Sbjct: 1765 DLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKI------AQ 1818

Query: 819  TEEQAELRRWEHLIFMKLCSSVFSLSEEELLRMRQEVHGCFAQMDRSLALPKIRARVLLQ 878
             EEQ +    E     K         ++ LL++  E        D++      R + L +
Sbjct: 1819 LEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQA-DKASTRLKQLKR 1877

Query: 879  QFQTAWREAEFVKLDQAVAAPELQQQSKVRKSRSKSKS 916
            Q + A  EA+     +     EL+  ++   + ++  S
Sbjct: 1878 QLEEAEEEAQRANASRRKLQRELEDATETADAMNREVS 1915



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 173/817 (21%), Positives = 335/817 (41%), Gaps = 119/817 (14%)

Query: 337  WQYESKLEPLPFTSADGVNEDLSLNDQMIDILSSEDPGSMLQALEELEIATLNRADADLE 396
            W+  +K++PL           L ++ Q  ++++ E+    L  + E ++A  NR   ++E
Sbjct: 828  WRLFTKVKPL-----------LQVSRQEEEMMAKEEE---LVKVREKQLAAENRL-TEME 872

Query: 397  ACRTQISKDIIALLLKNLTSSGHLSPQVERKMSAVFKKQFLL-----LENEIQEEYDRKM 451
              ++Q+  + + L  +    +   +   E +     KKQ L      LE  ++EE +R  
Sbjct: 873  TLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQ 932

Query: 452  VALTAECDLETRKKMENQYQREMMAMEEAE---------------ELLKRAGERSAVECS 496
              L AE     +KKM+   Q     +EE E               +L K   E+  +E  
Sbjct: 933  -HLQAE-----KKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQ 986

Query: 497  N--LLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVFQRNELHSIFFTQIKSAIFKGEL 554
            N  L +    LE      +  L +EE+ +K+  +L        H    T ++  + + E 
Sbjct: 987  NCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKL-----KNKHEAMITDLEERLRREEK 1041

Query: 555  KPEAAKMLLQNYSKIQENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLS 614
            + +  +   +       ++ + +   QA     L  +   +E   + LQ++  RV+    
Sbjct: 1042 QRQELEKTRRKLEGDSTDLSDQIAELQAQIA-ELKMQLAKKE---EELQAALARVE---- 1093

Query: 615  TAAAQLTHLIQK-HERAGYLDEDQMEMLLERA-QTEVFSIKQKLDNDLKQEKKKLHQKLI 672
              AAQ    ++K  E    + E Q ++  ERA + +    K+ L  +L+  K +L   L 
Sbjct: 1094 EEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLD 1153

Query: 673  TKRRRELLQKHREQRREQASVGEAFRTVED-AGQYLHQKRSLMEEHGATLEELQERLDQA 731
            +   ++ L+  REQ      V    +T+E+ A  +  Q + + ++H   +EEL E+L+Q 
Sbjct: 1154 STAAQQELRSKREQE-----VNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQT 1208

Query: 732  ALDDLRTLTLSLFEKATDELRRLQNSAMTQ-ELLKRGVPWLFLQQILEEHGKEMAARAEQ 790
                 + +  +L EKA   L   +     + ++L +G      +   E   K++ A+ ++
Sbjct: 1209 -----KRVKANL-EKAKQTLENERGELANEVKVLLQG------KGDSEHKRKKVEAQLQE 1256

Query: 791  LEGEERDRDQEGVQSVRQRLKDDAPEAVTEEQAELRRWEHLIFM------KLCSSVFSLS 844
            L+     +  EG     +R++ +  + VT+ Q EL     L+        KL     +L 
Sbjct: 1257 LQ----VKFNEG-----ERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSAL- 1306

Query: 845  EEELLRMRQEVHGCFAQMDRSLALPKIRARVLLQQFQTAWREAEFVK--LDQAVAAPELQ 902
             E  L+  QE+     +   SL+    +       F+    E E  K  L++ +A    Q
Sbjct: 1307 -ESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQ 1365

Query: 903  ---QQSKVRKSRSKSKSKGELLKKCIEDKIHLC----EEQASEDLVEKVRGELLRERVQR 955
                + K+  S    ++  E+ +K  +D   L     E+ A+ D +EK +  L +E    
Sbjct: 1366 VADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDL 1425

Query: 956  MEAQEGGFAQSLVALQFQKASRVTETLSAYTALLSIQDLLLEELSASEMLTKSACTQILE 1015
            +   +    Q   A   +K  +  + L A    +S +    EE   +E   +   T+ L 
Sbjct: 1426 LVDLD---HQRQSACNLEKKQKKFDQLLAEEKTISAK--YAEERDRAEAEAREKETKAL- 1479

Query: 1016 SHSRELQE-LERKLEDQLVQQEAAQQQQALASWQQWVADGPGILNEPGEVDSERQVSTVL 1074
            S +R L+E +E+K E + + ++   + + L S +  V            V    +    L
Sbjct: 1480 SLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGK---------SVHELEKSKRAL 1530

Query: 1075 HQALSKSQTLLEQHQQCLREEQQNSVVLEDLLENMEA 1111
             Q + + +T LE+ +  L+  +   + LE  L+ M+A
Sbjct: 1531 EQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKA 1567


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 140/717 (19%), Positives = 287/717 (40%), Gaps = 108/717 (15%)

Query: 440  ENEIQEEYDRKMVALTAECDLETRKKMENQYQREMMAMEEAEELLKRAGE-RSAVECSNL 498
            E E+Q+E ++    L  E +   R+++E QY++E    +E E+LL+   E R   E    
Sbjct: 1053 EEELQQEEEQ---LLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQ 1109

Query: 499  LRTLHGLEQEH---LRKSLALQQEEDFAKAHRQLAVFQRNELHSIFFTQIKSAIFKGELK 555
             R    L+QE    LR+    ++ ++  + +R+    Q+ E            + + E +
Sbjct: 1110 CREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEE----------EQLLREEPE 1159

Query: 556  PEAAKMLLQNY---SKIQENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGL 612
                + L + Y    ++Q+  E+L+   Q  +R    +++   E L +  +    R +  
Sbjct: 1160 KRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQ 1219

Query: 613  LSTAA-----------------------AQLTHLIQKHERAGYLDEDQMEMLLERAQTE- 648
             S                           Q   L     R     +D   +L E+ + + 
Sbjct: 1220 RSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDR 1279

Query: 649  ------------VFSIKQKLDNDLKQEKKKLHQKLITKRRRELLQKHREQRREQASVGEA 696
                         F  +++L+ + ++E K+  +K  ++  ++LL++ RE++R +      
Sbjct: 1280 EQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRK--SQEEKQLLREEREEKRRRQETDRK 1337

Query: 697  FRTVEDAGQYLHQKRSLMEEHGATLEELQERLDQAALDDLRTLTLSLFEKATDELRRLQN 756
            FR          ++  L++E        QER  +   ++LR        K  +E +RL+ 
Sbjct: 1338 FR----------EEEQLLQEREEQPLRRQERDRKFREEELRHQEQG--RKFLEEEQRLRR 1385

Query: 757  SAMTQELLKRGVPWLFL---QQILEEHGKEMAARAEQLEGEERDRD-QEGVQSVRQRLKD 812
                ++ LK           QQ+ ++  ++     +QL  +ERDR  +E  Q VR++ ++
Sbjct: 1386 QERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERE 1445

Query: 813  DAPEAVTEEQAELRRWEHLIFMKLCSSVFSLSEEELLRMRQEVHGCFAQMDRSLALPKIR 872
                   EE+ +LR+  H  F +    +    E++L   RQE    F + ++ L   +  
Sbjct: 1446 ---RKFLEEEQQLRQERHRKFREEEQLLQEREEQQL--HRQERDRKFLEEEQQLRRQERD 1500

Query: 873  ARVLLQQFQTAWREAEFVKLDQAVAAPE-----LQQQSKVRKSRSKSKSKGELLKKCIED 927
             +   Q+ ++   E +F++ +Q +   +     LQ++ ++R+     + + +  +K  E+
Sbjct: 1501 RKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREE 1560

Query: 928  KIHLCEEQASEDLVEKVRGELLRERVQRMEAQEGGFAQSLVALQFQKASRVTETLSAYTA 987
            +  L +E+  + L  + R    R   Q++  QE          Q +K     + L     
Sbjct: 1561 E-QLRQEREEQQLSRQERDRKFRLEEQKVRRQE----------QERKFMEDEQQLRRQEG 1609

Query: 988  LLSIQDLLLEELSASEMLTKSACTQILESHSRELQELERKLEDQLVQQEAAQQQQALASW 1047
               ++     +    E L +    Q L    R+ + LE   E QL +QE  ++QQ     
Sbjct: 1610 QQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEE--EPQLRRQE--REQQLRHDR 1665

Query: 1048 QQWVADGPGILNEPGEVDSERQVSTVLHQALSKSQTLLEQHQQCLREEQQNSVVLED 1104
             +   +   +L E  E    RQ          + +   E+ QQ  R+E++   + E+
Sbjct: 1666 DRKFREEEQLLQEGEEQQLRRQ---------ERDRKFREEEQQLRRQERERKFLQEE 1713



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 140/696 (20%), Positives = 279/696 (40%), Gaps = 119/696 (17%)

Query: 440  ENEIQEEYDRKMVALTAECDLETRKKMENQYQREMMAMEEAEELLKRAGERSAVECSNLL 499
            E E+Q+E ++    L  E +   R++ E QY+++    +E E+LL+   E+         
Sbjct: 993  EEELQQEEEQ---LLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREK--------- 1040

Query: 500  RTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVFQRNELHSIFFTQIKSAIFKGELKPEAA 559
            R L   E+++  +    Q+EE      R+    +R EL   +                  
Sbjct: 1041 RRLQERERQYREEEELQQEEEQLLGEERETR--RRQELERQY------------------ 1080

Query: 560  KMLLQNYSKIQENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQ 619
                +   ++Q+  E+L+      +R    +R    E   + LQ  E +           
Sbjct: 1081 ----RKEEELQQEEEQLLREEPEKRRRQERERQCREE---EELQQEEEQ----------- 1122

Query: 620  LTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLKQEKKKLHQKLITKRRRE- 678
                + + ER     E +    LER   E   ++Q+ +  L++E +K  ++ + ++ RE 
Sbjct: 1123 ----LLREER-----EKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREE 1173

Query: 679  ---------LLQKHREQRREQASVGEAFRTVEDAGQYLHQKRSLMEEHGATLEELQERLD 729
                     LL++ +E+RR++      +R  E+  +   ++R   E+  + L+   E   
Sbjct: 1174 EELQQEEEQLLREEQEKRRQERE--RQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEK 1231

Query: 730  QAALDDLRTLTLSLFEKATDELRRLQNSAMTQELLKRGVPWLFLQQILEEHGKEMAARAE 789
            + A+ D +        +  ++ R+L++S +     ++ +  L  +Q  +E  +E   R  
Sbjct: 1232 ENAVRDNKVYCKG---RENEQFRQLEDSQLRDRQSQQDLQHLLGEQ--QERDREQERRRW 1286

Query: 790  QL------EGEERDRDQEGVQSVRQRLKDDAPEAVTEEQAELRRWEHLIFMKLCSSVFSL 843
            Q       E E+ +R+++     R R   +  + + EE+ E RR +        +     
Sbjct: 1287 QQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQE-------TDRKFR 1339

Query: 844  SEEELLRMRQEVHGCFAQMDRSLALPKIR----ARVLL---QQFQTAWREAEFVKLDQAV 896
             EE+LL+ R+E      + DR     ++R     R  L   Q+ +   RE +F+K +Q +
Sbjct: 1340 EEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQL 1399

Query: 897  AAPELQQQSKVRKSRSKSKSKGELLKKCIEDKIHLCEEQASEDLVEKVRGELLRERVQRM 956
               E +QQ +  + R   + + +L ++  + K    E+Q      E+   + L E  Q  
Sbjct: 1400 RCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERER---KFLEEEQQLR 1456

Query: 957  EAQEGGFAQSLVALQFQKASRVTETLSAYTALLSIQDLLLEE----LSASEMLTKSACTQ 1012
            + +   F +    LQ ++  ++         L   Q L  +E        E+ ++    +
Sbjct: 1457 QERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERK 1516

Query: 1013 ILESHSR-ELQELERKL---EDQLVQQEAAQQQQALASWQQWVADGPGILNEPGEVDSER 1068
             LE   +   Q+ +RK    E QL +QE  QQ++          D      E  ++  ER
Sbjct: 1517 FLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRR---------QDRDRKFREEEQLRQER 1567

Query: 1069 QVSTVLHQALSKSQTLLEQHQQCLREEQQNSVVLED 1104
            +   +  Q   +   L EQ    +R ++Q    +ED
Sbjct: 1568 EEQQLSRQERDRKFRLEEQK---VRRQEQERKFMED 1600



 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 114/492 (23%), Positives = 197/492 (40%), Gaps = 87/492 (17%)

Query: 625  QKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLKQEKKKLHQKLITKRRRELLQKHR 684
            Q+ ER   + +++ E    + +T +   ++KL  +  Q +++L ++    R+ E  +  R
Sbjct: 229  QRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRR 288

Query: 685  EQRREQASVGEAFRTVEDAGQYLHQKRSLMEEHGATLEELQERLDQAALDDLRTLTLSLF 744
            E++ E+       R  +   +   ++R   EE      E QER +Q              
Sbjct: 289  ERQEEEQQQQRLRREQQLRRKQEEERREQQEER----REQQERREQQE------------ 332

Query: 745  EKATDELRRLQNSAMTQELLKRGVPWLFLQQILEEHGKEMAARAEQLEGEERDRDQEGVQ 804
            E+   +LRR Q     Q+L +            EE  +E   R EQ E E R++     Q
Sbjct: 333  ERREQQLRREQEERREQQLRRE----------QEEERREQQLRREQ-EEERREQQLRREQ 381

Query: 805  SVRQRLKDDAPEAVTEEQAELRRWEHLIFMKLCSSVFSLSEEELLRMRQEVHGCFAQMDR 864
             +R+       E     + +LRR +             L  E+ LR  Q+          
Sbjct: 382  QLRR-------EQQLRREQQLRREQ------------QLRREQQLRREQQ---------- 412

Query: 865  SLALPKIRARVLLQQFQTAWREAEFVKLDQAVAAPELQQQSKVRKSRSKSKSKGELLKKC 924
                  +R    L++ Q   RE E  + +Q     + +Q+ + ++ + + + + + LK+ 
Sbjct: 413  ------LRREQQLRREQQLRREQEEERHEQ-----KHEQERREQRLKREQEERRDWLKRE 461

Query: 925  IEDKIHLCE---EQASEDLVEKVRGELLR----ERVQRMEAQEGGFAQSLVALQFQKASR 977
             E + H  E   +Q   D  E+ R   L+    ER ++ E +E    +     + Q+  R
Sbjct: 462  EETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKR 521

Query: 978  VTETLSAYTALLSIQDLLLEELSASEMLTKSACTQILESHSRELQELERKLE---DQLVQ 1034
              E       L S Q L  E+    E L K    + LE   RE Q L+R+ E   DQL++
Sbjct: 522  QEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERRE-QRLKREQEERRDQLLK 580

Query: 1035 QEAAQQQQALASWQQWVADGPGILNEPGEVDSERQVSTVL---------HQALSKSQTLL 1085
            +E  ++QQ L   Q+   +      E   ++ E +    L          Q L KS+   
Sbjct: 581  REEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQE 640

Query: 1086 EQHQQCLREEQQ 1097
            E+ QQ LR EQQ
Sbjct: 641  ERRQQQLRREQQ 652



 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 155/754 (20%), Positives = 295/754 (39%), Gaps = 124/754 (16%)

Query: 440  ENEIQEEYDRKMVALTAECDLETRKKMENQYQREMMAMEEAEELLKRAGERSAVECSNLL 499
            E E+Q+E ++    L  E +   R+++E QY+ E    +E E+LL+   E+   E     
Sbjct: 1143 EEEVQQEEEQ---LLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQY 1199

Query: 500  RTLHGLEQ---------EHLRKSLALQQEEDFAKAHRQLAVFQRNELHSIFFTQIKSAIF 550
            R    L++         E  R  L  Q E +   A R   V+ +   +  F  Q++ +  
Sbjct: 1200 REEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQF-RQLEDSQL 1258

Query: 551  KG-------------------------------------ELKPEAAKMLLQNYSKIQENV 573
            +                                      +L+ E  K   +   K QE  
Sbjct: 1259 RDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEK 1318

Query: 574  EELMDFFQASKR-YHLSKRFGHREYLVQNLQSSETRVQGL-LSTAAAQLTH--------- 622
            + L +  +  +R     ++F   E L+Q  +    R Q         +L H         
Sbjct: 1319 QLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLE 1378

Query: 623  ----LIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLKQEKKKLHQKLITKRRRE 678
                L ++     +L E+Q     ER Q     ++Q  D   ++E+++L ++   ++ RE
Sbjct: 1379 EEQRLRRQERERKFLKEEQQLRCQEREQ----QLRQDRDRKFREEEQQLSRQERDRKFRE 1434

Query: 679  LLQKHREQRREQASVGEAFRTVEDAGQYLHQKRSLMEEHGATLEELQERLDQAALDDLRT 738
              Q+ R Q RE+  + E  +  ++  +   ++  L++E        QER D+  L++   
Sbjct: 1435 EEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQER-DRKFLEE--- 1490

Query: 739  LTLSLFEKATDELRRLQNSA--MTQELLKRGVPWLFLQQILEEHGKEMAARAEQLEGEER 796
                       +LRR +       QEL  +     FL++  + H ++   + + L+ E++
Sbjct: 1491 ---------EQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQ--RQRKFLQEEQQ 1539

Query: 797  DRDQEGVQSVRQRLKDDAPEAVTEEQAELRRWEHLIFMKLCSSVFSLSEEELLRMRQEVH 856
             R QE  Q   QR +D   +   EEQ    R E  +  +     F L E+++ R  QE  
Sbjct: 1540 LRRQERGQ---QRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERK 1596

Query: 857  GCFAQMDRSLALPKIRARVLLQQFQTAWREAEFV---KLDQAVAAPE-----LQQQSKVR 908
              F + ++ L   + + + L Q+    +RE E +   + +Q +   E     L+++ ++R
Sbjct: 1597 --FMEDEQQLRRQEGQQQ-LRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLR 1653

Query: 909  KSRSKSKSKGELLKKCIEDKIHLCEEQASEDLVEKVRGELLRERVQRMEAQ--EGGFAQS 966
            +   + + + +  +K  E++  L +E   + L  + R    RE  Q++  Q  E  F Q 
Sbjct: 1654 RQEREQQLRHDRDRKFREEE-QLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQE 1712

Query: 967  LVALQFQKASRVTETLSAYTALLSIQDLLLEELSASEMLTKSACTQILESH----SRELQ 1022
               L+ Q+  R              ++ L +E    ++  +    +ILE       RE Q
Sbjct: 1713 EQQLRRQELERKFRE----------EEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQ 1762

Query: 1023 ELERKLEDQLVQQEAAQQQQALASWQQWVADGPGILNEPGEVDSERQVSTVLHQ------ 1076
            +L R+  D+  ++E  Q +Q     Q    +      E  ++  ER+   +  Q      
Sbjct: 1763 QLRRQERDRKFREE-EQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKY 1821

Query: 1077 ALSKSQTLLEQHQQCLREEQQNSVVLEDLLENME 1110
               + Q  LE+ +Q LR+E+      E+     E
Sbjct: 1822 RWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQE 1855



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 149/715 (20%), Positives = 279/715 (39%), Gaps = 114/715 (15%)

Query: 425  ERKMSAVFKKQFLLLENEIQEEYD-RKMVALTAECDL--ETRKKMENQYQREMMAMEEAE 481
            ER+   + ++Q L  E +++ E   R+   L  E  L  E + + E Q +RE     E E
Sbjct: 371  ERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQE 430

Query: 482  ELLKRAGERSAVECSNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVFQRNELHSIF 541
            E               L R     EQE  R  L  ++E +  +  R+    +R++     
Sbjct: 431  EERHEQKHEQERREQRLKR-----EQEERRDWLKREEETERHEQERRKQQLKRDQ----- 480

Query: 542  FTQIKSAIFKGELKPEAAKMLLQNYSKIQENVEELMDFFQASKRYHLSKRFGHREYLVQN 601
                     + E +    K+  +   + QE  E+ +   Q  +R    KR    E L Q 
Sbjct: 481  ---------EEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQR 531

Query: 602  LQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLK 661
            L+S +                 +++ +      E++ E LL+R +          +  L+
Sbjct: 532  LRSEQQ----------------LRREQ------EERREQLLKREE----------EKRLE 559

Query: 662  QEKKKLHQKLITKRRRELLQKHREQRREQASVGEAFRTVEDAGQYLHQKRSLMEEHGATL 721
            QE+++   K   + RR+ L K  E+RR+Q       R   +  + L Q+    E      
Sbjct: 560  QERREQRLKREQEERRDQLLKREEERRQQ-------RLKREQEERLEQRLKREEVERLEQ 612

Query: 722  EELQE-RLDQAALDDLRTLTL----SLFEKATDELRRLQNSAMTQELLKRGVPWLFLQQI 776
            EE +E RL +   ++ R   L       E+   +LRR Q     Q L +        Q++
Sbjct: 613  EERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRL 672

Query: 777  LEEHGKEMAAR--AEQLEGEERDRDQEGVQSVRQRLKDDAPEAVT-------EEQAELRR 827
              EH +E   +  AE+ + + R+R +  +   + +L+ +A    +       +++ + RR
Sbjct: 673  KREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRR 732

Query: 828  WEHLIFMKLCSSVFSLSEEELLRMRQE--------VHGCFAQMDRSLALPKIRARVLLQQ 879
             E     +   S     EEE    +Q+             A+        ++ AR  L++
Sbjct: 733  QEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLRE 792

Query: 880  FQTAWREAEFVKLDQAVAAPELQQQSKVRKSRSKSKSKGELLKKCIEDKIHLCEEQASED 939
             +     AE  +  +    PE +++ + R+ R + + + + L    E++  L   + ++ 
Sbjct: 793  QRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFL----EEEEQLQRRERAQQ 848

Query: 940  LVEKVRGELLRERVQRMEAQEGGFAQSLVALQFQKASRVTETLSAYTALLSIQDLLLEEL 999
            L E+  G  L+E  +R  +QE    Q       ++  R   TL A  AL   Q+ L +E 
Sbjct: 849  LQEEEDG--LQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPAL---QEQLRKE- 902

Query: 1000 SASEMLTKSACTQILESHSRELQELERKLEDQLVQQEAAQQQQALASWQQWVADGPGILN 1059
                        Q+L+    ELQ  ER+   +  Q+   ++++ L   ++       +L 
Sbjct: 903  -----------QQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEE------QLLR 945

Query: 1060 EPGE----VDSERQVSTVLHQALSKSQTLLEQHQQCLREEQQNSVVLEDLLENME 1110
            E  E     + ERQ          + Q L E+ ++  R+E++     E+ L+  E
Sbjct: 946  EEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEE 1000



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 138/672 (20%), Positives = 259/672 (38%), Gaps = 106/672 (15%)

Query: 444  QEEYDRKMVALTAECDLETRKKMENQYQREMMAMEEAEELLKRAGERSAVECSNLLRTLH 503
            +E   R+   L  E + E R++   + ++E+  +EE E+L +R  ER+      L     
Sbjct: 801  EERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRR--ERA----QQLQEEED 854

Query: 504  GLEQEHLRKSLALQQEEDFAKAHRQLAVFQRNELHSIFFTQIKSAIFKGELKPEAAKMLL 563
            GL+++  R+    Q+ +   K   QL   ++   H+++             KP   + L 
Sbjct: 855  GLQEDQERRRSQEQRRDQ--KWRWQLEEERKRRRHTLY------------AKPALQEQLR 900

Query: 564  QNYSKIQENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHL 623
            +    +QE  EEL    +  +R    +R    E   + LQ  E ++          L   
Sbjct: 901  KEQQLLQEEEEELQREEREKRRRQEQERQYREE---EQLQQEEEQL----------LREE 947

Query: 624  IQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLKQEKKKLHQKLITKRRRELLQKH 683
             +K  R     + + +  L++ + ++   + +     ++EKK   ++ + +   +LL++ 
Sbjct: 948  REKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREE 1007

Query: 684  REQRREQASVGEAFRTVEDAGQYLHQKRSLMEEHGATLEELQERLDQAALDDLRTLTLSL 743
            RE+RR Q          E   QY  +     EE     EE ++R  Q      R      
Sbjct: 1008 REKRRRQ----------EWERQYRKKDELQQEEEQLLREEREKRRLQERERQYR------ 1051

Query: 744  FEKATDELRRLQNSAMTQELLKRGVPWLFLQQILEEHGKEMAARAEQLEGEERDRDQEGV 803
                 +EL++ +   + +E   R    L  Q   EE  ++   +  + E E+R R +   
Sbjct: 1052 ---EEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERER 1108

Query: 804  QSVRQRLKDDAPEAVTEEQAELRRWEHLIFMKLCSSVFSLSEEELLRMRQEVHGCFAQMD 863
            Q   +       E +  E+ E RR + L             EE+LLR             
Sbjct: 1109 QCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREE----------- 1157

Query: 864  RSLALPKIRARVLLQQFQTAWREAEFVKLDQAVAAPELQQQSKVRKSRSKSKSKGELLKK 923
                 P+ R R   Q+ +  +RE E  +L Q       ++Q K R+ R +   + E L++
Sbjct: 1158 -----PEKRRR---QELERQYREEE--ELQQEEEQLLREEQEKRRQERERQYREEEELQR 1207

Query: 924  CIEDKIHLCEEQASEDLV---EKVRGELLRERVQRMEAQEGGFAQSLVALQFQKASRVTE 980
                + +  E+Q S DL    E  +   +R+     + +E    + L   Q +       
Sbjct: 1208 QKRKQRYRDEDQRS-DLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQ---- 1262

Query: 981  TLSAYTALLSIQDL--LLEELSASEMLTKSACTQILESHSRELQELERKLEDQLVQQEAA 1038
                     S QDL  LL E    +   +    Q  + H  E ++LER+ + +  +++  
Sbjct: 1263 ---------SQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRK 1313

Query: 1039 QQQQALASWQQWVADGPGILNEPGEVDSERQVSTVLHQALSKSQTLLEQHQQCLREEQQN 1098
             Q++              +L E  E    RQ +    +   + Q L E+ +Q LR ++++
Sbjct: 1314 SQEE------------KQLLREEREEKRRRQETD--RKFREEEQLLQEREEQPLRRQERD 1359

Query: 1099 SVVLEDLLENME 1110
                E+ L + E
Sbjct: 1360 RKFREEELRHQE 1371



 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 144/712 (20%), Positives = 269/712 (37%), Gaps = 83/712 (11%)

Query: 438  LLENEIQEEYDRKMVALTAECDLET---RKKMENQYQREMMAMEEAEELLKRAGERSAVE 494
            LL++  QEE  R+      + + E    R++   + +RE+   EE  E  +R  +R    
Sbjct: 109  LLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQR 168

Query: 495  CSNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVFQRNELHSIFFTQIKSAIFKGEL 554
                       ++E  R+    Q+ E+      QL   + +E       +        EL
Sbjct: 169  ----------RDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLEL 218

Query: 555  KPEAAKMLLQNYSKIQENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLS 614
            + +  +   Q   + Q+ V      FQ  +     KR        + LQ  E + Q  L 
Sbjct: 219  RRKGREEKQQQRRERQDRV------FQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQ 272

Query: 615  TAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLKQEKKKLHQKLITK 674
                QL  L ++  R    +E+Q +  L R Q     +++K      QE+++  Q+   +
Sbjct: 273  EEEEQLRKLERQELRRERQEEEQQQQRLRREQ----QLRRK------QEEERREQQEERR 322

Query: 675  RRRELLQKHREQRREQASVGEAFRTVEDAGQYLHQKR---SLMEEHGATLEELQERLDQA 731
             ++E  ++  E+R +Q    +  R  +   +   ++R    L  E      E Q R +Q 
Sbjct: 323  EQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQ- 381

Query: 732  ALDDLRTLTLSLFEKATDELRRLQNSAMTQELLK----RGVPWLFLQQILEEHGK--EMA 785
             L   + L      +   +LRR Q     Q+L +    R    L  +Q  E H +  E  
Sbjct: 382  QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQE 441

Query: 786  ARAEQLEGEERDR----------DQEGVQSVRQRLKDDAPEAVTEEQAELRRWEHLIFMK 835
             R ++L+ E+ +R          ++   +  +Q+LK D  E   E   +L   E     +
Sbjct: 442  RREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQE 501

Query: 836  LCSSVFSLSEEELLRMRQEVHGCFAQMDRSLALPKIRARVLLQQFQTAWREAEFVKLDQA 895
                     +EE    R +      Q +      ++R+   L++ Q   RE    + ++ 
Sbjct: 502  RREQQLRREQEERREQRLK-----RQEEEERLQQRLRSEQQLRREQEERREQLLKREEEK 556

Query: 896  VAAPELQQQSKVRKSRSKSKSKGELLKKCIEDKIHLCEEQASEDLVEKVRGELLRERVQR 955
                E ++Q   R  R + + + +LLK+  E +    +++   +  E++   L RE V+R
Sbjct: 557  RLEQERREQ---RLKREQEERRDQLLKREEERR----QQRLKREQEERLEQRLKREEVER 609

Query: 956  MEAQEGGFAQSLVALQFQKASRVTETLSAYTALLSIQDLLLEELSASEMLTKSACTQILE 1015
            +E QE    Q L   + ++  R     S        Q L  E+    E   K       E
Sbjct: 610  LE-QEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKRE-----E 663

Query: 1016 SHSRELQELERKLEDQLVQQEAAQQQQALA---------SWQQWVADGPG------ILNE 1060
               R  Q L+R+ E++  +QE A+++Q  A          W QW  +         + + 
Sbjct: 664  EEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKW-QWQLESEADARQSKVYSR 722

Query: 1061 PGEVDSERQVSTVLHQALSKSQTLLEQHQQCLREEQQNSVVLEDLLENMEAD 1112
            P + + +R+      +   +   L  Q ++    +QQ      D     +A+
Sbjct: 723  PRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAE 774



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 81/378 (21%), Positives = 151/378 (39%), Gaps = 45/378 (11%)

Query: 669  QKLITKRRRELLQKHREQRREQASVGEAFRTVEDAGQYLHQKRSLMEEHGATLEELQERL 728
            + L+  RR+E  Q+  E R  Q          E+ GQ   QKR   E   A  EE  E+ 
Sbjct: 107  ESLLQDRRQEEDQRRFEPRDRQLE--------EEPGQRRRQKRQEQERELAEGEEQSEKQ 158

Query: 729  DQAALDDLRTLTLSLFEKATDELRRLQNSAMTQELLKRGVPWLFLQQILEEHGKEMAARA 788
            ++    D +     L+ +  +   R +  A  ++L           Q  + H  E     
Sbjct: 159  ERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQL-----------QSCKGHETEEFPDE 207

Query: 789  EQLEGEE----RDRDQEGVQSVRQRLKDDAPEAVTEEQAELRRWEHLIFMKLCSSVFSLS 844
            EQL   E    R + +E  Q  R+  +D   +   EE+ E R+ E +    L      L 
Sbjct: 208  EQLRRRELLELRRKGREEKQQQRRERQDRVFQ--EEEEKEWRKRETV----LRKEEEKLQ 261

Query: 845  EEELLRMRQEVHGCFAQMDRSLALPKIRARVLLQQFQTAWREAEFVKLDQAVAAPELQQQ 904
            EEE  R R+         +    L K+  + L ++ Q   ++ + ++ +Q +   + +++
Sbjct: 262  EEEPQRQRE-------LQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEER 314

Query: 905  SKVRKSRSKSKSKGELLKKCIEDKIHLCEEQASEDLVEKVRGELLRERVQRMEAQEGGFA 964
             + ++ R + + + E  ++  E ++   +E+  E  + + + E  RE+  R E +E    
Sbjct: 315  REQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERRE 374

Query: 965  QSLVALQFQKASRVTETLSAYTALLSIQDLLLEELSASEMLTKSACTQILESHSRELQEL 1024
            Q L         R  + L     L   Q L  E+    E   +       E   R  Q+L
Sbjct: 375  QQL---------RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 425

Query: 1025 ERKLEDQLVQQEAAQQQQ 1042
             R+ E++  +Q+  Q+++
Sbjct: 426  RREQEEERHEQKHEQERR 443



 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 79/421 (18%), Positives = 167/421 (39%), Gaps = 43/421 (10%)

Query: 434  KQFLLLENEIQ-EEYDRKMVALTAECDLETRKKMENQYQ-----REMMAMEEAEELLKRA 487
            ++FL  E +++ +E DRK            RK +E + Q     R+   ++E ++L ++ 
Sbjct: 1485 RKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQE 1544

Query: 488  -GERSAVECSNLLRTLHGLEQEHLRKSLALQQ-------EEDFAKAHRQLAVFQRNELHS 539
             G++   +     R    L QE   + L+ Q+       EE   +   Q   F  +E   
Sbjct: 1545 RGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDE--- 1601

Query: 540  IFFTQIKSAIFKGELKPEAAKMLLQNYSKIQENVEELMDFFQASKRYHLSKRFGHREYLV 599
                Q++    + +L+ E  +   ++   +QE  E+ +   +  +++   +    R+   
Sbjct: 1602 ---QQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQERE 1658

Query: 600  QNLQSSETRV----QGLLSTAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQK 655
            Q L+    R     + LL     Q    +++ ER     E++ ++            +Q+
Sbjct: 1659 QQLRHDRDRKFREEEQLLQEGEEQQ---LRRQERDRKFREEEQQLR-----------RQE 1704

Query: 656  LDNDLKQEKKKLHQKLITKRRRELLQKHREQRREQASVGEAFRTVEDAGQYLHQKRSLM- 714
             +    QE+++L ++ + ++ RE  Q  +E  +EQ    E +R + +  Q   ++     
Sbjct: 1705 RERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQL 1764

Query: 715  --EEHGATLEELQERLDQAALDDLRTLTLSLFEKATDELRRLQNSAMTQELLKRG-VPWL 771
              +E      E ++   +     LR+       +  ++LR+ +     +   + G   W 
Sbjct: 1765 RRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWE 1824

Query: 772  FLQQILEEHGKEMAA-RAEQLEGEERDRDQEGVQSVRQRLKDDAPEAVTEEQAELRRWEH 830
              Q  LEE  + +   R  Q   EE+   QE  +   Q L  +  +   +E+    R EH
Sbjct: 1825 EEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEH 1884

Query: 831  L 831
            +
Sbjct: 1885 I 1885



 Score = 35.4 bits (80), Expect = 0.36
 Identities = 72/320 (22%), Positives = 136/320 (42%), Gaps = 32/320 (10%)

Query: 437  LLLENEIQE----EYDRKMVA-----LTAECDLETRKKMENQYQREMMAMEEAEE--LLK 485
            LL E E Q+    E DRK +         E + + R   + +++ E   ++E EE  L +
Sbjct: 1627 LLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRR 1686

Query: 486  RAGERSAVECSNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVFQRNELHSIFFTQI 545
            +  +R   E    LR     E++ L++   L+++E   K   +  + Q  E   +   + 
Sbjct: 1687 QERDRKFREEEQQLRRQER-ERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQER 1745

Query: 546  KSAIFKGE-LKPEAAKMLLQNYSKIQENVEELM----DFFQASKRYHLSKRFGHREYLVQ 600
               I + E L+PE  +  L+   + ++  EE         Q  +     ++F   E L Q
Sbjct: 1746 YRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQ 1805

Query: 601  NLQSSETRVQ---GLLSTAAAQLT------HLIQKHERAGYLDEDQMEMLLERAQTEVFS 651
              +  + R Q   G       QL        L Q+ +R  Y  E+Q     E+++ E   
Sbjct: 1806 EREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQ-YRAEEQFATQ-EKSRREEQE 1863

Query: 652  IKQKLDNDLKQEK-KKLHQKLITKRRRELLQKHREQRREQASVGEAFRTVEDAGQYLHQK 710
            + Q+ +   +QE+ +KL ++ I ++++E  Q+HR+    ++  G+    + + G   HQ 
Sbjct: 1864 LWQEEEQKRRQERERKLREEHIRRQQKE-EQRHRQVGEIKSQEGKGHGRLLEPG--THQF 1920

Query: 711  RSLMEEHGATLEELQERLDQ 730
             S+        E +QE+  Q
Sbjct: 1921 ASVPVRSSPLYEYIQEQRSQ 1940


>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
          Length = 2325

 Score = 74.7 bits (182), Expect = 5e-13
 Identities = 140/643 (21%), Positives = 283/643 (44%), Gaps = 83/643 (12%)

Query: 434  KQFLLLENEIQEEYDRKMVALTAECDLETRKKMENQYQREMMAMEEAEELLKRAGER--S 491
            +Q  + + EI +E ++ + A   + D +   K + +   E+  +++  E+ +R  +    
Sbjct: 1509 EQHKIKQEEILKEINKIVAA--KDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQ 1566

Query: 492  AVECSNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVFQRNELHSIFFTQIKSAIFK 551
             ++ S +L      E E L+  +  QQ+E  A   RQL   ++ ELH +  + +++    
Sbjct: 1567 VLKESEVLLQAKRAELEKLKSQVTSQQQE-MAVLDRQLG-HKKEELHLLQGSMVQAKADL 1624

Query: 552  GELKPEAAKMLLQNYSKIQE--NVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRV 609
             E        + +  + I+E  ++ E + F +      +S+R      + Q ++  E  +
Sbjct: 1625 QEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENL 1684

Query: 610  QGLLSTAAAQLTHL--------IQKHERAGY-LDEDQMEMLLERAQTEVFSIKQKLDN-- 658
            Q +L   +   T L        ++ HE  G  L  DQ    LE+ Q  V   K +L+N  
Sbjct: 1685 QVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQ 1744

Query: 659  DLKQEKK---KLHQKLITKRRRELLQKHREQRREQASVGEAFRTVEDAGQY--LHQKRSL 713
             + Q++K   +  ++L+ + +RE+ +   E R  Q+ V    +  ED  +   + +K+  
Sbjct: 1745 QISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLA 1804

Query: 714  MEEHGATLEELQERLDQAALDDLRTLTLSLFEKATDELRR----LQN--SAMTQELLKRG 767
              +      E   +++Q+ L+ L  L +   ++  D+L R    L N  SAM Q+L ++ 
Sbjct: 1805 QTKRVLAAAEENSKMEQSNLEKLE-LNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEK- 1862

Query: 768  VPWLFLQQILEEHGKEMAARAEQLEGEERD-----RDQEGVQSVRQRLKDDAPEAVTEEQ 822
                  ++ +    +E+A   + L   ++D     + Q+ + S + RL+ D  E      
Sbjct: 1863 ------REAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWAN--- 1913

Query: 823  AELRRWEHLIFMKLCSSVFSLSEEELLRMRQEVHGCFAQMDRSLALPKIRARVLLQQFQT 882
                R+E       C       +++L  ++ E+       +  L L  ++  ++ Q+ Q 
Sbjct: 1914 ----RFED------CQKEEETKQQQLQVLQNEIE------ENKLKL--VQQEMMFQRLQK 1955

Query: 883  AWREAEFVKLDQAVAAPELQQQSKVRKSRSKSKSK-GELLKKCI--EDKIH-LCEEQASE 938
              RE+E  KL+ +    + +QQ ++ K  +  KSK  ++L K +  E+++  L EE+   
Sbjct: 1956 E-RESEESKLETSKVTLK-EQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWC 2013

Query: 939  DLVEKVRGEL---LRERVQRMEAQEGGFAQSLVALQFQKASRVTETLSAYTALLSIQDLL 995
            + +EK   +    L ER Q++  + G     L+ALQ     +  +++ A  +LL  Q  L
Sbjct: 2014 ESLEKTLSQTKRQLSEREQQLVEKSG----ELLALQ-----KEADSMRADFSLLRNQ-FL 2063

Query: 996  LEELSASEMLTKSACTQILESHSRELQELERKLEDQLVQQEAA 1038
             E   A + +        ++    E   LE+K E+  +Q+E A
Sbjct: 2064 TERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMA 2106



 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 130/611 (21%), Positives = 240/611 (39%), Gaps = 97/611 (15%)

Query: 573  VEELMDFFQASKR----YHLSKRFGHREY---------LVQNLQSSETRVQGLLSTAAAQ 619
            +E++M   ++ KR       SKR   +E          L+Q  +S E  V+ L  T    
Sbjct: 1328 LEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRT---- 1383

Query: 620  LTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLKQEKKKLHQKLITKRRREL 679
                +QK ++     +  +E L+   + E      K   D+  E + + +K + KRR EL
Sbjct: 1384 ----VQKRQQQKDFIDGNVESLMTELEIEK---SLKHHEDIVDEIECI-EKTLLKRRSEL 1435

Query: 680  LQKHR---EQRREQASVGEAFRTVEDAGQYLHQKRSLMEEHGATLEELQERLDQAALDDL 736
             +  R   E   E +   E  +T     ++   KRSL++   +  EEL+ R  + A++  
Sbjct: 1436 READRLLAEAESELSCTKE--KTKNAVEKFTDAKRSLLQTE-SDAEELERRAQETAVN-- 1490

Query: 737  RTLTLSLFEKATDELRRLQNSAMTQELLKRGVPWLFLQQILEEHGKEMAARAEQLEGEER 796
                     KA  +LR LQ  A   E  K     +  ++IL+E  K +AA+         
Sbjct: 1491 -------LVKADQQLRSLQADAKDLEQHK-----IKQEEILKEINKIVAAK--------- 1529

Query: 797  DRDQEGVQSVRQRLKDDAPEAVTE-EQAELRRWEHLIFMKLCSSVFSLSEEELLRMRQEV 855
            D D + +   +++L ++  +   + E AE     HL  +K    +      EL +++ +V
Sbjct: 1530 DSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQV 1589

Query: 856  HGC---FAQMDRSLALPKIRARVLLQQFQTAWREA-EFVKLDQAVAAPELQQQSKVRKSR 911
                   A +DR L   K    +L      A  +  E ++L +     +     +V+   
Sbjct: 1590 TSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLL 1649

Query: 912  SK-SKSKGELLKKCIEDKIHLC----EEQASEDLVEKVRGELLRERVQRMEAQEGGFAQS 966
             + S  KGEL  +  E K  L     E +  E+ ++ V  ++ + + +     +    ++
Sbjct: 1650 EELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLEN 1709

Query: 967  --LVALQFQKASRVTETLSAYTALLSIQDLLLEELSASEMLTKSACT---QILESHSREL 1021
              L  L+ Q   RV+E      A+L  + L LE L       K       Q+LE   RE+
Sbjct: 1710 HELQGLKLQHDQRVSELEKTQVAVLE-EKLELENLQQISQQQKGEIEWQKQLLERDKREI 1768

Query: 1022 QEL---ERKLED--QLVQQEAAQQQQALASWQQWVADGPGILNEPGE------------- 1063
            + +    R L+   + + +E    Q+    W++ +A    +L    E             
Sbjct: 1769 ERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLE 1828

Query: 1064 ---------VDSERQVSTVLHQALSKSQTLLEQHQQCLREEQQNSVVLEDLLENMEADTF 1114
                     +D   +    LH  +S  Q  L++ ++ +   Q+    ++D L   + D  
Sbjct: 1829 LNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLL 1888

Query: 1115 ATLCSQELRLA 1125
             T   Q++ L+
Sbjct: 1889 HTTKHQDVLLS 1899



 Score = 47.8 bits (112), Expect = 7e-05
 Identities = 126/532 (23%), Positives = 213/532 (40%), Gaps = 77/532 (14%)

Query: 338  QYESKLEPLPFTSADGVNEDLSLNDQMIDILSSEDPGSM-----LQALEELEIATLNRAD 392
            Q++ ++  L  T    + E L L +  +  +S +  G +     L   ++ EI  +    
Sbjct: 1718 QHDQRVSELEKTQVAVLEEKLELEN--LQQISQQQKGEIEWQKQLLERDKREIERMTAES 1775

Query: 393  ADLEACRTQISKDIIALLLKNLTSSGHLSPQVERKMSAVFKKQFLLLENEIQEEYDRKMV 452
              L++C   +SK+   L  K       L+ Q +R ++A  +     +E    E+ +  + 
Sbjct: 1776 RALQSCVECLSKEKEDLQEKCDIWEKKLA-QTKRVLAAAEENS--KMEQSNLEKLELNVR 1832

Query: 453  ALTAECDLETRKK---------MENQYQREMMAMEEAEELLKRAGERSAVECSNLLRTLH 503
             L  E D   R K         M+ Q Q +  A+   +E L    +   +   +LL T  
Sbjct: 1833 KLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTK 1892

Query: 504  GL-----EQEHLRKSLA--------LQQEEDFAKAHRQLAVFQR----NEL----HSIFF 542
                   EQ  L+K ++         Q+EE+  +  +QL V Q     N+L      + F
Sbjct: 1893 HQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQ--QQLQVLQNEIEENKLKLVQQEMMF 1950

Query: 543  TQIKSAIFKGELKPEAAKMLLQNYSKIQENVEELMDFFQASKRYHLSKRFGHREYLVQNL 602
             +++      E K E +K+ L+      E  +EL D  Q SK   +  +    E  V+ L
Sbjct: 1951 QRLQKERESEESKLETSKVTLKEQQHQLE--KELTD--QKSKLDQVLSKVLAAEERVRTL 2006

Query: 603  QSSETRVQGLLSTAAAQLTHLIQKH----ERAGYLDEDQMEMLLERAQTEVFSIKQKLDN 658
            Q  E   + L  T +     L ++     E++G L   Q E    RA   +    Q L  
Sbjct: 2007 QEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLR-NQFLTE 2065

Query: 659  DLKQEKKKLHQKLITKRRRELLQKHR-EQRREQASVGEAFRTVEDAGQYLHQK-RSLMEE 716
              K EK+    K   K +R  L+K+  EQ++E + + +   T+E   Q  H++ R LM+E
Sbjct: 2066 RKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKE 2125

Query: 717  HGATLEELQERLDQAA-LDDLRTLTLSLFEKATDELRRLQNSAMTQ--ELLKRGVPWLFL 773
                  E  E   Q A   DL    + +    +D +R L++    +    LK       L
Sbjct: 2126 LNQMQYEYTELKKQMANQKDLERRQMEI----SDAMRTLKSEVKDEIRTSLKN------L 2175

Query: 774  QQILEEHGKEMAA---RAEQLEGEERDRDQEGVQSVRQRLKDDAPEAVTEEQ 822
             Q L E   ++ A   R E LEGE        ++S+++ L     E   EE+
Sbjct: 2176 NQFLPELPADLEAILERNENLEGE--------LESLKENLPFTMNEGPFEEK 2219



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 139/666 (20%), Positives = 288/666 (43%), Gaps = 96/666 (14%)

Query: 434  KQFLLLENE-IQEEYDRKMVALTAECDLETRKKMENQYQREMMAMEEAEELLKRAGERSA 492
            ++F L E E ++ + ++KM+      + E  K  + ++  E+   ++  + LK       
Sbjct: 265  ERFSLEEVERLERDLEKKMI------ETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQK 318

Query: 493  VECSNLLRTLHG----LEQEHL------RKSLALQQEEDFAKAHRQLAVFQRNELHSIFF 542
              C  L   L+     L+Q+ +      +K   L+QE  F K     A F+    +   +
Sbjct: 319  QSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKID---AKFEPLNYYPSEY 375

Query: 543  TQIKSAIFKGEL--KPEAAKMLLQNYSKIQENVEEL----MDFFQASKRYHLSKRFGHRE 596
             +I  A  +     K    + +    S I ++ + +    M+  +  +  H++ R GH  
Sbjct: 376  AEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLR-GHTP 434

Query: 597  YLVQNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQK- 655
               Q L+  E ++     T  ++L   I+K E+      ++ + L E  Q +  S   K 
Sbjct: 435  LDTQ-LEDKEKKISAA-QTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKD 492

Query: 656  -----------LDNDLKQEKKKLHQKLITKRRRELLQKHREQRREQASVGEAFRTVEDAG 704
                       L N L+QE   L  ++  K+++E+  K +E +  Q ++ ++  + +   
Sbjct: 493  LLYKQLSGRLQLVNKLRQEALDLELQM-EKQKQEIAGKQKEIKDLQIAI-DSLDSKDPKH 550

Query: 705  QYLHQKRSLMEEHGATLEELQERLDQAALDDLRTLTLSLFEKATDELRRLQNSAM----- 759
             ++  ++S  E+    + +  ++L+ + LD++    LS   K T+E++ L+         
Sbjct: 551  SHMKAQKSGKEQQLDIMNKQYQQLE-SRLDEI----LSRIAKETEEIKDLEEQLTEGQIA 605

Query: 760  TQELLKRGVPWLFLQQILEEHGKEMAARAEQLEGEERD-RDQEGVQSVRQRLKDDAPEAV 818
              E LK+ +  +     L+E+   +  +A Q + E R  RD++  +++ QRL +     V
Sbjct: 606  ANEALKKDLEGVISG--LQEYLGTIKGQATQAQNECRKLRDEK--ETLLQRLTE-----V 656

Query: 819  TEEQAELRRWEHLIFMKLCSSVFSLSE-EELLRMRQEVHGCFAQMDRSLAL--PKIRARV 875
             +E+ +L     ++ M   +    L+E E  L+ + EV+    Q    L+    ++ AR+
Sbjct: 657  EQERDQLE----IVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARL 712

Query: 876  LLQQFQTAWREAEFVKLDQAVAAPELQQQSKVRKSRSKSKSKGELLKKCIEDKIHLCEEQ 935
             L+  +    + E  K+ +     +   Q+++ K R   K+   L K    ++    +EQ
Sbjct: 713  NLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNA--LGKAQFSEE----KEQ 766

Query: 936  ASEDLVEKVR-----GELLRERVQRMEAQEGGFAQSLVALQFQKASRVTET---LSAYTA 987
             + +L  K++       LL+++++  +         LV  + + A+RV E    L   T 
Sbjct: 767  ENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPE-EVAARVDELRRKLKLGTG 825

Query: 988  LLSIQDLLLEELSASEMLTKSACT---QILESHSRELQEL-ERKLEDQLVQQEAAQQQQA 1043
             ++I        S S++L KS      Q  E  +R   E  E ++ ++ +Q+E A QQ+ 
Sbjct: 826  EMNIH-------SPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEK 878

Query: 1044 LASWQQ 1049
            LA+ Q+
Sbjct: 879  LATGQE 884



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 102/460 (22%), Positives = 192/460 (41%), Gaps = 80/460 (17%)

Query: 356  EDLSLNDQMIDILSSEDPGSMLQALEELEIATLNRADADLEACRTQISKDIIAL--LLKN 413
            E+LS     +++  SE    +    +E+E     + + +L+    Q+SK    L  +L  
Sbjct: 1650 EELSFQKGELNVQISERKTQLTLIKQEIE-----KEEENLQVVLRQMSKHKTELKNILDM 1704

Query: 414  LTSSGH----LSPQVERKMSAVFKKQFLLLENEIQEEYDRKMVALTAECDLETRKKMENQ 469
            L    H    L  Q ++++S + K Q  +LE +++ E + + ++   + ++E +K++  +
Sbjct: 1705 LQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELE-NLQQISQQQKGEIEWQKQLLER 1763

Query: 470  YQREMMAMEEAEELLKRAGERSAVECSNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQL 529
             +RE+  M      L+     S VEC +        E+E L++   +  E+  A+  R L
Sbjct: 1764 DKREIERMTAESRALQ-----SCVECLSK-------EKEDLQEKCDIW-EKKLAQTKRVL 1810

Query: 530  AVFQRN---ELHSIFFTQIKSAIFKGELKP-EAAKMLLQN---------------YSKIQ 570
            A  + N   E  ++   ++     + EL      K+ L N                + +Q
Sbjct: 1811 AAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQ 1870

Query: 571  ENVEELMDFFQASKR--YHLSKRFGHREYLVQNLQSSETRVQGLLSTAA----------- 617
            E +  + D    +K+   H +K   H++ L+    S +TR+Q  +S  A           
Sbjct: 1871 EELANVQDHLNLAKQDLLHTTK---HQDVLL----SEQTRLQKDISEWANRFEDCQKEEE 1923

Query: 618  --AQLTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDND---LKQEKKKLHQKLI 672
               Q   ++Q       L   Q EM+ +R Q E  S + KL+     LK+++ +L ++L 
Sbjct: 1924 TKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELT 1983

Query: 673  TKRRR--ELLQKHREQRREQASVGEAFRTVEDAGQYLHQ-KRSLME------EHGATLEE 723
             ++ +  ++L K         ++ E  R  E   + L Q KR L E      E    L  
Sbjct: 1984 DQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLA 2043

Query: 724  LQERLDQAALDD--LRTLTLSLFEKATDELRRLQNSAMTQ 761
            LQ+  D    D   LR   L+  +KA  ++  L+ +   Q
Sbjct: 2044 LQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQ 2083



 Score = 37.4 bits (85), Expect = 0.095
 Identities = 89/443 (20%), Positives = 167/443 (37%), Gaps = 81/443 (18%)

Query: 460  LETRKKMENQYQREMMAM-EEAEELLKRAGERSAVECSNLLRTLHGLEQEHLRKSLALQQ 518
            L T K    Q Q E   + +E E LL+R  E   VE       +  ++ E++RK LA + 
Sbjct: 625  LGTIKGQATQAQNECRKLRDEKETLLQRLTE---VEQERDQLEIVAMDAENMRKELA-EL 680

Query: 519  EEDFAKAHRQLAVFQRNELH-SIFFTQIKSAIFKGELKPEAAKMLLQNYSKIQENVEELM 577
            E    + H   A  Q+ +   S +  ++++ +   + +    K  L+  +++ +  +  +
Sbjct: 681  ESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSAL 740

Query: 578  DFFQASKRYHLSKRFGHREYL-------------VQNLQSSETRVQGLLSTAAAQLTH-- 622
                  +R  L    G  ++              +++LQ     ++  L      L H  
Sbjct: 741  QAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVV 800

Query: 623  --LIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLKQEKKKLHQKLITK------ 674
              L++  E A  +DE + ++ L   +  + S    L   L   +K+  + L         
Sbjct: 801  DGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDE 860

Query: 675  ---RRRELLQKHREQRREQASVGEAFRT-----------------------VEDAGQYLH 708
               R R+L ++   Q+ + A+  E FR                        +E+   YL 
Sbjct: 861  AQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQ 920

Query: 709  QKRSLMEE-HGATLEELQERLDQAALDDLRTLTLSLFEKATD------------ELRRLQ 755
            +    MEE  G T  +LQE  ++      +   L   +K  D            EL++L+
Sbjct: 921  ENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLK 980

Query: 756  NSAMTQELLKRGVPWLFLQQILEEHGKEM---AARAEQLEGEERDRDQEGVQSVRQRLKD 812
             +  T + L      +   Q+   HG  M     RAE+L+  ER   ++  Q+ R     
Sbjct: 981  KAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAER-FSRKAAQAARD---- 1035

Query: 813  DAPEAVTEEQAELRRWEHLIFMK 835
                 +T  +AE+   ++L+  K
Sbjct: 1036 -----LTRAEAEIELLQNLLRQK 1053


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 73.9 bits (180), Expect = 9e-13
 Identities = 203/874 (23%), Positives = 344/874 (39%), Gaps = 139/874 (15%)

Query: 370  SEDP-GSMLQALEELEIATLNRADADLEACRTQISKDIIALLLKNLTSSGHLSPQVERKM 428
            S DP G+ LQ     +        AD +A R Q+ ++    LL+ +   G    + +R  
Sbjct: 1215 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE--QALLEEIERHGEKVEECQR-- 1270

Query: 429  SAVFKKQFLLLENEIQEEYDRKMVALTAECD--LETRKKMENQYQREMMAMEEAEELLKR 486
               F KQ++   N I++ Y+ ++V   A+ +      KK + Q   E +  E  +  L+ 
Sbjct: 1271 ---FAKQYI---NAIKD-YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD--LRT 1321

Query: 487  AGERSAVECSNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVFQRNELHSIFFTQIK 546
                     S  ++ +     E LR+   +++EE  A+  R     +  E+ +    Q +
Sbjct: 1322 HYSELTTLTSQYIKFI----SETLRR---MEEEERLAEQQRAEERERLAEVEAALEKQRQ 1374

Query: 547  SAIFKGELKPEAAKMLLQNYSKIQENV---EELMDFFQASKRYHLSKRFGHREYLVQNLQ 603
             A    + K +A +   +   ++QE V   EE     Q  KR         +E L Q  Q
Sbjct: 1375 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR-------SIQEELQQLRQ 1427

Query: 604  SSETRVQGLLSTA-AAQLTHL-IQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLK 661
            SSE  +Q     A AA+ + L I++  R   L  +  E     A+ E+ +++ + +    
Sbjct: 1428 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEE--A 1485

Query: 662  QEKKKLHQKLITKRRRELLQKHREQRREQASVGEAFRTVEDAGQYLHQKRSL--MEEHGA 719
            + +K+  Q+   + RR++  +   QR+ QA V  A R   +A     ++R+L  +EE   
Sbjct: 1486 EAQKRQAQEEAERLRRQV--QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1543

Query: 720  TLEELQERLDQAALDDLRTLTLSL-----------------FEKATDELRR-LQNSAMTQ 761
              EE + RL QA ++  R + ++L                 F + T +L R LQ   +  
Sbjct: 1544 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1603

Query: 762  ELLKRGVPWLFLQQILEEHGKEMAARAEQ-------------LEGEERDRDQEGVQSVRQ 808
              L+        QQ   E  +E A R  +             L+ EE  + +   Q+  +
Sbjct: 1604 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1663

Query: 809  RLKDDAPEAV-----TEEQAELRRWEHLIFMKLCSSVFSLSEEELLRMRQEVHGCFAQ-M 862
            + K++A          EEQA  +R               L+E+EL + RQ   G   Q +
Sbjct: 1664 KQKEEAEREARRRGKAEEQAVRQR--------------ELAEQELEKQRQLAEGTAQQRL 1709

Query: 863  DRSLALPKIRARVLLQQFQTAWREAEFVKLDQAVAAPELQQQSKVRKSRSKSKSKGELLK 922
                 L ++RA     + Q    E E  +L Q  AA   Q++ ++    +K +++ E+L 
Sbjct: 1710 AAEQELIRLRAETEQGEQQRQLLEEELARL-QREAAAATQKRQELEAELAKVRAEMEVL- 1767

Query: 923  KCIEDKIHLCEEQASEDLVEKVRGELLRERVQRMEAQEGGF------AQSLVAL-QFQKA 975
              +  K    EE  S     K          QR+EA+ G F      A  L AL +  K 
Sbjct: 1768 --LASKARAEEESRSTSEKSK----------QRLEAEAGRFRELAEEAARLRALAEEAKR 1815

Query: 976  SRVTETLSAYTALLSIQDLLLEELSASEMLT--KSACTQILESHSRELQELERKLEDQLV 1033
             R      A       + +L E+L+A    T  K+     L+    E + L R  ED+  
Sbjct: 1816 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1875

Query: 1034 QQEAAQQQQALASWQQWVADGPGILNEPGEVDSERQVSTVLHQALSKSQTLLEQHQQCLR 1093
            Q+   ++Q   A  +  + +    L +  + + ERQ   V               +  LR
Sbjct: 1876 QRRRLEEQ--AAQHKADIEERLAQLRKASDSELERQKGLV---------------EDTLR 1918

Query: 1094 EEQQNSVVLEDLLENMEADTFATLCSQELRLASYLARMAMVPGATLRRLLSVVLPTASQP 1153
            + +Q   V E++L    +   A     EL L   L R+      TLR      L  A Q 
Sbjct: 1919 QRRQ---VEEEILALKASFEKAAAGKAELELE--LGRIRSNAEDTLRSKEQAELEAARQR 1973

Query: 1154 QLLALLDSATERHVDHAAESDGGAEQADVGRRRK 1187
            Q LA  +    R  +   +    AE+ +  R+RK
Sbjct: 1974 Q-LAAEEERRRREAEERVQKSLAAEE-EAARQRK 2005



 Score = 67.8 bits (164), Expect = 7e-11
 Identities = 156/761 (20%), Positives = 291/761 (38%), Gaps = 77/761 (10%)

Query: 399  RTQISKDIIALLLKNLTSSGHLSPQVERKMSAVFKKQFLLLENEIQEEYDRKMVALTAEC 458
            R Q+ ++I+AL   +   +     ++E ++  +       L ++ Q E +       A  
Sbjct: 1920 RRQVEEEILALKA-SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1978

Query: 459  DLETRKKMENQYQREMMAMEEAEELLKRA---GERSAVECSNLLRTLHGLEQEHLRKSLA 515
            +   R++ E + Q+ + A EEA    K A    ER   +     R     EQE  R+ L 
Sbjct: 1979 EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ-LQ 2037

Query: 516  LQQEEDFAKAHRQLAVFQRNELHSIFFTQIKSAIFKGELKPEAAKMLLQNYSKIQENVEE 575
            L QE     A ++L   Q  E    F  Q K        + E  + L Q  S + +   E
Sbjct: 2038 LAQEA----AQKRL---QAEEKAHAFAVQQK--------EQELQQTLQQEQSVLDQLRGE 2082

Query: 576  LMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDE 635
                 +A++    ++    RE      Q  E   + L  +A  Q     Q    A  L +
Sbjct: 2083 AEAARRAAEEAEEARVQAEREAAQSRRQVEEA--ERLKQSAEEQAQARAQAQAAAEKLRK 2140

Query: 636  DQMEMLLERAQTEVFSIKQKLDNDLKQEKKKLHQKLITKRRRELLQKHREQRREQASVGE 695
            +  +    RAQ E  +++QK   D + EK   H+K   +  R+  Q  +E    +  + E
Sbjct: 2141 EAEQEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQTLRQKAQVEQELTTLRLQLEE 2197

Query: 696  AFRTVEDAGQYLHQKRSLMEEHGATLEELQERLDQAALDDLRTLTLSLFEKATDELRRLQ 755
                     + L + ++   E      +++E L    +       L    +A +    L+
Sbjct: 2198 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2257

Query: 756  NSAMTQELLKRGVPWLFLQQILEEHGK-----EMAARAEQLEGEERDRDQEGVQSVRQRL 810
            +   TQ  L+       ++Q+ EE  +     + AAR  QL  EE    Q  +     + 
Sbjct: 2258 DKDNTQRFLQEEAE--KMKQVAEEAARLSVAAQEAARLRQL-AEEDLAQQRALAEKMLKE 2314

Query: 811  KDDAPEAVTEEQAELRRWEHLIFMKLCSSVFSLSEEELLRMRQEVHGCFAQMDRSLALPK 870
            K  A +  T  +AE          +L      L++E+  R++++      Q+       +
Sbjct: 2315 KMQAVQEATRLKAE---------AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQ 2365

Query: 871  IRARVLLQQFQTAWREAEFVKLDQA-VAAPELQQQSKVRKSRSKSKSKGELLKK---CIE 926
                   Q+      EAE +KL  A ++  + + +   ++ R +++  GE L +     +
Sbjct: 2366 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2425

Query: 927  DKIHLCEEQASEDLVEKVRGELLRERVQRMEAQEGGFAQSLVALQF--------QKASRV 978
            +K+ L +    +        E LRE +  +E ++    Q    LQ         Q+   +
Sbjct: 2426 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2485

Query: 979  TETLSAYTALLSIQDLLLEELSASEMLTKSACTQILESHSRELQELERKLEDQLVQQEAA 1038
             ET +   + LS +D LL+     E   K+   Q+ +    + Q+L    E Q  QQ+  
Sbjct: 2486 QETQALQQSFLSEKDSLLQRERFIEQ-EKAKLEQLFQDEVAKAQQLRE--EQQRQQQQME 2542

Query: 1039 QQQQALASWQQWVADGPGILNEPGEVDSERQVSTVLHQALSKSQTLLEQHQQCLREEQ-- 1096
            Q++Q L +                 ++  R+      + + + Q  L+Q +Q  R+++  
Sbjct: 2543 QERQRLVA----------------SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2586

Query: 1097 --QNSVVLEDLLENMEADTFATLCSQELRLASYLARMAMVP 1135
              + +  L + L+ +E    A L   E   AS +A    +P
Sbjct: 2587 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2627


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 73.9 bits (180), Expect = 9e-13
 Identities = 203/874 (23%), Positives = 344/874 (39%), Gaps = 139/874 (15%)

Query: 370  SEDP-GSMLQALEELEIATLNRADADLEACRTQISKDIIALLLKNLTSSGHLSPQVERKM 428
            S DP G+ LQ     +        AD +A R Q+ ++    LL+ +   G    + +R  
Sbjct: 1219 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE--QALLEEIERHGEKVEECQR-- 1274

Query: 429  SAVFKKQFLLLENEIQEEYDRKMVALTAECD--LETRKKMENQYQREMMAMEEAEELLKR 486
               F KQ++   N I++ Y+ ++V   A+ +      KK + Q   E +  E  +  L+ 
Sbjct: 1275 ---FAKQYI---NAIKD-YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD--LRT 1325

Query: 487  AGERSAVECSNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVFQRNELHSIFFTQIK 546
                     S  ++ +     E LR+   +++EE  A+  R     +  E+ +    Q +
Sbjct: 1326 HYSELTTLTSQYIKFI----SETLRR---MEEEERLAEQQRAEERERLAEVEAALEKQRQ 1378

Query: 547  SAIFKGELKPEAAKMLLQNYSKIQENV---EELMDFFQASKRYHLSKRFGHREYLVQNLQ 603
             A    + K +A +   +   ++QE V   EE     Q  KR         +E L Q  Q
Sbjct: 1379 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR-------SIQEELQQLRQ 1431

Query: 604  SSETRVQGLLSTA-AAQLTHL-IQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLK 661
            SSE  +Q     A AA+ + L I++  R   L  +  E     A+ E+ +++ + +    
Sbjct: 1432 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEE--A 1489

Query: 662  QEKKKLHQKLITKRRRELLQKHREQRREQASVGEAFRTVEDAGQYLHQKRSL--MEEHGA 719
            + +K+  Q+   + RR++  +   QR+ QA V  A R   +A     ++R+L  +EE   
Sbjct: 1490 EAQKRQAQEEAERLRRQV--QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1547

Query: 720  TLEELQERLDQAALDDLRTLTLSL-----------------FEKATDELRR-LQNSAMTQ 761
              EE + RL QA ++  R + ++L                 F + T +L R LQ   +  
Sbjct: 1548 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1607

Query: 762  ELLKRGVPWLFLQQILEEHGKEMAARAEQ-------------LEGEERDRDQEGVQSVRQ 808
              L+        QQ   E  +E A R  +             L+ EE  + +   Q+  +
Sbjct: 1608 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1667

Query: 809  RLKDDAPEAV-----TEEQAELRRWEHLIFMKLCSSVFSLSEEELLRMRQEVHGCFAQ-M 862
            + K++A          EEQA  +R               L+E+EL + RQ   G   Q +
Sbjct: 1668 KQKEEAEREARRRGKAEEQAVRQR--------------ELAEQELEKQRQLAEGTAQQRL 1713

Query: 863  DRSLALPKIRARVLLQQFQTAWREAEFVKLDQAVAAPELQQQSKVRKSRSKSKSKGELLK 922
                 L ++RA     + Q    E E  +L Q  AA   Q++ ++    +K +++ E+L 
Sbjct: 1714 AAEQELIRLRAETEQGEQQRQLLEEELARL-QREAAAATQKRQELEAELAKVRAEMEVL- 1771

Query: 923  KCIEDKIHLCEEQASEDLVEKVRGELLRERVQRMEAQEGGF------AQSLVAL-QFQKA 975
              +  K    EE  S     K          QR+EA+ G F      A  L AL +  K 
Sbjct: 1772 --LASKARAEEESRSTSEKSK----------QRLEAEAGRFRELAEEAARLRALAEEAKR 1819

Query: 976  SRVTETLSAYTALLSIQDLLLEELSASEMLT--KSACTQILESHSRELQELERKLEDQLV 1033
             R      A       + +L E+L+A    T  K+     L+    E + L R  ED+  
Sbjct: 1820 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1879

Query: 1034 QQEAAQQQQALASWQQWVADGPGILNEPGEVDSERQVSTVLHQALSKSQTLLEQHQQCLR 1093
            Q+   ++Q   A  +  + +    L +  + + ERQ   V               +  LR
Sbjct: 1880 QRRRLEEQ--AAQHKADIEERLAQLRKASDSELERQKGLV---------------EDTLR 1922

Query: 1094 EEQQNSVVLEDLLENMEADTFATLCSQELRLASYLARMAMVPGATLRRLLSVVLPTASQP 1153
            + +Q   V E++L    +   A     EL L   L R+      TLR      L  A Q 
Sbjct: 1923 QRRQ---VEEEILALKASFEKAAAGKAELELE--LGRIRSNAEDTLRSKEQAELEAARQR 1977

Query: 1154 QLLALLDSATERHVDHAAESDGGAEQADVGRRRK 1187
            Q LA  +    R  +   +    AE+ +  R+RK
Sbjct: 1978 Q-LAAEEERRRREAEERVQKSLAAEE-EAARQRK 2009



 Score = 67.8 bits (164), Expect = 7e-11
 Identities = 156/761 (20%), Positives = 291/761 (38%), Gaps = 77/761 (10%)

Query: 399  RTQISKDIIALLLKNLTSSGHLSPQVERKMSAVFKKQFLLLENEIQEEYDRKMVALTAEC 458
            R Q+ ++I+AL   +   +     ++E ++  +       L ++ Q E +       A  
Sbjct: 1924 RRQVEEEILALKA-SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1982

Query: 459  DLETRKKMENQYQREMMAMEEAEELLKRA---GERSAVECSNLLRTLHGLEQEHLRKSLA 515
            +   R++ E + Q+ + A EEA    K A    ER   +     R     EQE  R+ L 
Sbjct: 1983 EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ-LQ 2041

Query: 516  LQQEEDFAKAHRQLAVFQRNELHSIFFTQIKSAIFKGELKPEAAKMLLQNYSKIQENVEE 575
            L QE     A ++L   Q  E    F  Q K        + E  + L Q  S + +   E
Sbjct: 2042 LAQEA----AQKRL---QAEEKAHAFAVQQK--------EQELQQTLQQEQSVLDQLRGE 2086

Query: 576  LMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDE 635
                 +A++    ++    RE      Q  E   + L  +A  Q     Q    A  L +
Sbjct: 2087 AEAARRAAEEAEEARVQAEREAAQSRRQVEEA--ERLKQSAEEQAQARAQAQAAAEKLRK 2144

Query: 636  DQMEMLLERAQTEVFSIKQKLDNDLKQEKKKLHQKLITKRRRELLQKHREQRREQASVGE 695
            +  +    RAQ E  +++QK   D + EK   H+K   +  R+  Q  +E    +  + E
Sbjct: 2145 EAEQEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQTLRQKAQVEQELTTLRLQLEE 2201

Query: 696  AFRTVEDAGQYLHQKRSLMEEHGATLEELQERLDQAALDDLRTLTLSLFEKATDELRRLQ 755
                     + L + ++   E      +++E L    +       L    +A +    L+
Sbjct: 2202 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2261

Query: 756  NSAMTQELLKRGVPWLFLQQILEEHGK-----EMAARAEQLEGEERDRDQEGVQSVRQRL 810
            +   TQ  L+       ++Q+ EE  +     + AAR  QL  EE    Q  +     + 
Sbjct: 2262 DKDNTQRFLQEEAE--KMKQVAEEAARLSVAAQEAARLRQL-AEEDLAQQRALAEKMLKE 2318

Query: 811  KDDAPEAVTEEQAELRRWEHLIFMKLCSSVFSLSEEELLRMRQEVHGCFAQMDRSLALPK 870
            K  A +  T  +AE          +L      L++E+  R++++      Q+       +
Sbjct: 2319 KMQAVQEATRLKAE---------AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQ 2369

Query: 871  IRARVLLQQFQTAWREAEFVKLDQA-VAAPELQQQSKVRKSRSKSKSKGELLKK---CIE 926
                   Q+      EAE +KL  A ++  + + +   ++ R +++  GE L +     +
Sbjct: 2370 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2429

Query: 927  DKIHLCEEQASEDLVEKVRGELLRERVQRMEAQEGGFAQSLVALQF--------QKASRV 978
            +K+ L +    +        E LRE +  +E ++    Q    LQ         Q+   +
Sbjct: 2430 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2489

Query: 979  TETLSAYTALLSIQDLLLEELSASEMLTKSACTQILESHSRELQELERKLEDQLVQQEAA 1038
             ET +   + LS +D LL+     E   K+   Q+ +    + Q+L    E Q  QQ+  
Sbjct: 2490 QETQALQQSFLSEKDSLLQRERFIEQ-EKAKLEQLFQDEVAKAQQLRE--EQQRQQQQME 2546

Query: 1039 QQQQALASWQQWVADGPGILNEPGEVDSERQVSTVLHQALSKSQTLLEQHQQCLREEQ-- 1096
            Q++Q L +                 ++  R+      + + + Q  L+Q +Q  R+++  
Sbjct: 2547 QERQRLVA----------------SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2590

Query: 1097 --QNSVVLEDLLENMEADTFATLCSQELRLASYLARMAMVP 1135
              + +  L + L+ +E    A L   E   AS +A    +P
Sbjct: 2591 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2631


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 73.9 bits (180), Expect = 9e-13
 Identities = 203/874 (23%), Positives = 344/874 (39%), Gaps = 139/874 (15%)

Query: 370  SEDP-GSMLQALEELEIATLNRADADLEACRTQISKDIIALLLKNLTSSGHLSPQVERKM 428
            S DP G+ LQ     +        AD +A R Q+ ++    LL+ +   G    + +R  
Sbjct: 1215 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE--QALLEEIERHGEKVEECQR-- 1270

Query: 429  SAVFKKQFLLLENEIQEEYDRKMVALTAECD--LETRKKMENQYQREMMAMEEAEELLKR 486
               F KQ++   N I++ Y+ ++V   A+ +      KK + Q   E +  E  +  L+ 
Sbjct: 1271 ---FAKQYI---NAIKD-YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD--LRT 1321

Query: 487  AGERSAVECSNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVFQRNELHSIFFTQIK 546
                     S  ++ +     E LR+   +++EE  A+  R     +  E+ +    Q +
Sbjct: 1322 HYSELTTLTSQYIKFI----SETLRR---MEEEERLAEQQRAEERERLAEVEAALEKQRQ 1374

Query: 547  SAIFKGELKPEAAKMLLQNYSKIQENV---EELMDFFQASKRYHLSKRFGHREYLVQNLQ 603
             A    + K +A +   +   ++QE V   EE     Q  KR         +E L Q  Q
Sbjct: 1375 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR-------SIQEELQQLRQ 1427

Query: 604  SSETRVQGLLSTA-AAQLTHL-IQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLK 661
            SSE  +Q     A AA+ + L I++  R   L  +  E     A+ E+ +++ + +    
Sbjct: 1428 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEE--A 1485

Query: 662  QEKKKLHQKLITKRRRELLQKHREQRREQASVGEAFRTVEDAGQYLHQKRSL--MEEHGA 719
            + +K+  Q+   + RR++  +   QR+ QA V  A R   +A     ++R+L  +EE   
Sbjct: 1486 EAQKRQAQEEAERLRRQV--QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1543

Query: 720  TLEELQERLDQAALDDLRTLTLSL-----------------FEKATDELRR-LQNSAMTQ 761
              EE + RL QA ++  R + ++L                 F + T +L R LQ   +  
Sbjct: 1544 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1603

Query: 762  ELLKRGVPWLFLQQILEEHGKEMAARAEQ-------------LEGEERDRDQEGVQSVRQ 808
              L+        QQ   E  +E A R  +             L+ EE  + +   Q+  +
Sbjct: 1604 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1663

Query: 809  RLKDDAPEAV-----TEEQAELRRWEHLIFMKLCSSVFSLSEEELLRMRQEVHGCFAQ-M 862
            + K++A          EEQA  +R               L+E+EL + RQ   G   Q +
Sbjct: 1664 KQKEEAEREARRRGKAEEQAVRQR--------------ELAEQELEKQRQLAEGTAQQRL 1709

Query: 863  DRSLALPKIRARVLLQQFQTAWREAEFVKLDQAVAAPELQQQSKVRKSRSKSKSKGELLK 922
                 L ++RA     + Q    E E  +L Q  AA   Q++ ++    +K +++ E+L 
Sbjct: 1710 AAEQELIRLRAETEQGEQQRQLLEEELARL-QREAAAATQKRQELEAELAKVRAEMEVL- 1767

Query: 923  KCIEDKIHLCEEQASEDLVEKVRGELLRERVQRMEAQEGGF------AQSLVAL-QFQKA 975
              +  K    EE  S     K          QR+EA+ G F      A  L AL +  K 
Sbjct: 1768 --LASKARAEEESRSTSEKSK----------QRLEAEAGRFRELAEEAARLRALAEEAKR 1815

Query: 976  SRVTETLSAYTALLSIQDLLLEELSASEMLT--KSACTQILESHSRELQELERKLEDQLV 1033
             R      A       + +L E+L+A    T  K+     L+    E + L R  ED+  
Sbjct: 1816 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1875

Query: 1034 QQEAAQQQQALASWQQWVADGPGILNEPGEVDSERQVSTVLHQALSKSQTLLEQHQQCLR 1093
            Q+   ++Q   A  +  + +    L +  + + ERQ   V               +  LR
Sbjct: 1876 QRRRLEEQ--AAQHKADIEERLAQLRKASDSELERQKGLV---------------EDTLR 1918

Query: 1094 EEQQNSVVLEDLLENMEADTFATLCSQELRLASYLARMAMVPGATLRRLLSVVLPTASQP 1153
            + +Q   V E++L    +   A     EL L   L R+      TLR      L  A Q 
Sbjct: 1919 QRRQ---VEEEILALKASFEKAAAGKAELELE--LGRIRSNAEDTLRSKEQAELEAARQR 1973

Query: 1154 QLLALLDSATERHVDHAAESDGGAEQADVGRRRK 1187
            Q LA  +    R  +   +    AE+ +  R+RK
Sbjct: 1974 Q-LAAEEERRRREAEERVQKSLAAEE-EAARQRK 2005



 Score = 67.8 bits (164), Expect = 7e-11
 Identities = 156/761 (20%), Positives = 291/761 (38%), Gaps = 77/761 (10%)

Query: 399  RTQISKDIIALLLKNLTSSGHLSPQVERKMSAVFKKQFLLLENEIQEEYDRKMVALTAEC 458
            R Q+ ++I+AL   +   +     ++E ++  +       L ++ Q E +       A  
Sbjct: 1920 RRQVEEEILALKA-SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1978

Query: 459  DLETRKKMENQYQREMMAMEEAEELLKRA---GERSAVECSNLLRTLHGLEQEHLRKSLA 515
            +   R++ E + Q+ + A EEA    K A    ER   +     R     EQE  R+ L 
Sbjct: 1979 EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ-LQ 2037

Query: 516  LQQEEDFAKAHRQLAVFQRNELHSIFFTQIKSAIFKGELKPEAAKMLLQNYSKIQENVEE 575
            L QE     A ++L   Q  E    F  Q K        + E  + L Q  S + +   E
Sbjct: 2038 LAQEA----AQKRL---QAEEKAHAFAVQQK--------EQELQQTLQQEQSVLDQLRGE 2082

Query: 576  LMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDE 635
                 +A++    ++    RE      Q  E   + L  +A  Q     Q    A  L +
Sbjct: 2083 AEAARRAAEEAEEARVQAEREAAQSRRQVEEA--ERLKQSAEEQAQARAQAQAAAEKLRK 2140

Query: 636  DQMEMLLERAQTEVFSIKQKLDNDLKQEKKKLHQKLITKRRRELLQKHREQRREQASVGE 695
            +  +    RAQ E  +++QK   D + EK   H+K   +  R+  Q  +E    +  + E
Sbjct: 2141 EAEQEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQTLRQKAQVEQELTTLRLQLEE 2197

Query: 696  AFRTVEDAGQYLHQKRSLMEEHGATLEELQERLDQAALDDLRTLTLSLFEKATDELRRLQ 755
                     + L + ++   E      +++E L    +       L    +A +    L+
Sbjct: 2198 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2257

Query: 756  NSAMTQELLKRGVPWLFLQQILEEHGK-----EMAARAEQLEGEERDRDQEGVQSVRQRL 810
            +   TQ  L+       ++Q+ EE  +     + AAR  QL  EE    Q  +     + 
Sbjct: 2258 DKDNTQRFLQEEAE--KMKQVAEEAARLSVAAQEAARLRQL-AEEDLAQQRALAEKMLKE 2314

Query: 811  KDDAPEAVTEEQAELRRWEHLIFMKLCSSVFSLSEEELLRMRQEVHGCFAQMDRSLALPK 870
            K  A +  T  +AE          +L      L++E+  R++++      Q+       +
Sbjct: 2315 KMQAVQEATRLKAE---------AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQ 2365

Query: 871  IRARVLLQQFQTAWREAEFVKLDQA-VAAPELQQQSKVRKSRSKSKSKGELLKK---CIE 926
                   Q+      EAE +KL  A ++  + + +   ++ R +++  GE L +     +
Sbjct: 2366 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2425

Query: 927  DKIHLCEEQASEDLVEKVRGELLRERVQRMEAQEGGFAQSLVALQF--------QKASRV 978
            +K+ L +    +        E LRE +  +E ++    Q    LQ         Q+   +
Sbjct: 2426 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2485

Query: 979  TETLSAYTALLSIQDLLLEELSASEMLTKSACTQILESHSRELQELERKLEDQLVQQEAA 1038
             ET +   + LS +D LL+     E   K+   Q+ +    + Q+L    E Q  QQ+  
Sbjct: 2486 QETQALQQSFLSEKDSLLQRERFIEQ-EKAKLEQLFQDEVAKAQQLRE--EQQRQQQQME 2542

Query: 1039 QQQQALASWQQWVADGPGILNEPGEVDSERQVSTVLHQALSKSQTLLEQHQQCLREEQ-- 1096
            Q++Q L +                 ++  R+      + + + Q  L+Q +Q  R+++  
Sbjct: 2543 QERQRLVA----------------SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2586

Query: 1097 --QNSVVLEDLLENMEADTFATLCSQELRLASYLARMAMVP 1135
              + +  L + L+ +E    A L   E   AS +A    +P
Sbjct: 2587 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2627


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 73.9 bits (180), Expect = 9e-13
 Identities = 203/874 (23%), Positives = 344/874 (39%), Gaps = 139/874 (15%)

Query: 370  SEDP-GSMLQALEELEIATLNRADADLEACRTQISKDIIALLLKNLTSSGHLSPQVERKM 428
            S DP G+ LQ     +        AD +A R Q+ ++    LL+ +   G    + +R  
Sbjct: 1183 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE--QALLEEIERHGEKVEECQR-- 1238

Query: 429  SAVFKKQFLLLENEIQEEYDRKMVALTAECD--LETRKKMENQYQREMMAMEEAEELLKR 486
               F KQ++   N I++ Y+ ++V   A+ +      KK + Q   E +  E  +  L+ 
Sbjct: 1239 ---FAKQYI---NAIKD-YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD--LRT 1289

Query: 487  AGERSAVECSNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVFQRNELHSIFFTQIK 546
                     S  ++ +     E LR+   +++EE  A+  R     +  E+ +    Q +
Sbjct: 1290 HYSELTTLTSQYIKFI----SETLRR---MEEEERLAEQQRAEERERLAEVEAALEKQRQ 1342

Query: 547  SAIFKGELKPEAAKMLLQNYSKIQENV---EELMDFFQASKRYHLSKRFGHREYLVQNLQ 603
             A    + K +A +   +   ++QE V   EE     Q  KR         +E L Q  Q
Sbjct: 1343 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR-------SIQEELQQLRQ 1395

Query: 604  SSETRVQGLLSTA-AAQLTHL-IQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLK 661
            SSE  +Q     A AA+ + L I++  R   L  +  E     A+ E+ +++ + +    
Sbjct: 1396 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEE--A 1453

Query: 662  QEKKKLHQKLITKRRRELLQKHREQRREQASVGEAFRTVEDAGQYLHQKRSL--MEEHGA 719
            + +K+  Q+   + RR++  +   QR+ QA V  A R   +A     ++R+L  +EE   
Sbjct: 1454 EAQKRQAQEEAERLRRQV--QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1511

Query: 720  TLEELQERLDQAALDDLRTLTLSL-----------------FEKATDELRR-LQNSAMTQ 761
              EE + RL QA ++  R + ++L                 F + T +L R LQ   +  
Sbjct: 1512 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1571

Query: 762  ELLKRGVPWLFLQQILEEHGKEMAARAEQ-------------LEGEERDRDQEGVQSVRQ 808
              L+        QQ   E  +E A R  +             L+ EE  + +   Q+  +
Sbjct: 1572 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1631

Query: 809  RLKDDAPEAV-----TEEQAELRRWEHLIFMKLCSSVFSLSEEELLRMRQEVHGCFAQ-M 862
            + K++A          EEQA  +R               L+E+EL + RQ   G   Q +
Sbjct: 1632 KQKEEAEREARRRGKAEEQAVRQR--------------ELAEQELEKQRQLAEGTAQQRL 1677

Query: 863  DRSLALPKIRARVLLQQFQTAWREAEFVKLDQAVAAPELQQQSKVRKSRSKSKSKGELLK 922
                 L ++RA     + Q    E E  +L Q  AA   Q++ ++    +K +++ E+L 
Sbjct: 1678 AAEQELIRLRAETEQGEQQRQLLEEELARL-QREAAAATQKRQELEAELAKVRAEMEVL- 1735

Query: 923  KCIEDKIHLCEEQASEDLVEKVRGELLRERVQRMEAQEGGF------AQSLVAL-QFQKA 975
              +  K    EE  S     K          QR+EA+ G F      A  L AL +  K 
Sbjct: 1736 --LASKARAEEESRSTSEKSK----------QRLEAEAGRFRELAEEAARLRALAEEAKR 1783

Query: 976  SRVTETLSAYTALLSIQDLLLEELSASEMLT--KSACTQILESHSRELQELERKLEDQLV 1033
             R      A       + +L E+L+A    T  K+     L+    E + L R  ED+  
Sbjct: 1784 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1843

Query: 1034 QQEAAQQQQALASWQQWVADGPGILNEPGEVDSERQVSTVLHQALSKSQTLLEQHQQCLR 1093
            Q+   ++Q   A  +  + +    L +  + + ERQ   V               +  LR
Sbjct: 1844 QRRRLEEQ--AAQHKADIEERLAQLRKASDSELERQKGLV---------------EDTLR 1886

Query: 1094 EEQQNSVVLEDLLENMEADTFATLCSQELRLASYLARMAMVPGATLRRLLSVVLPTASQP 1153
            + +Q   V E++L    +   A     EL L   L R+      TLR      L  A Q 
Sbjct: 1887 QRRQ---VEEEILALKASFEKAAAGKAELELE--LGRIRSNAEDTLRSKEQAELEAARQR 1941

Query: 1154 QLLALLDSATERHVDHAAESDGGAEQADVGRRRK 1187
            Q LA  +    R  +   +    AE+ +  R+RK
Sbjct: 1942 Q-LAAEEERRRREAEERVQKSLAAEE-EAARQRK 1973



 Score = 67.8 bits (164), Expect = 7e-11
 Identities = 156/761 (20%), Positives = 291/761 (38%), Gaps = 77/761 (10%)

Query: 399  RTQISKDIIALLLKNLTSSGHLSPQVERKMSAVFKKQFLLLENEIQEEYDRKMVALTAEC 458
            R Q+ ++I+AL   +   +     ++E ++  +       L ++ Q E +       A  
Sbjct: 1888 RRQVEEEILALKA-SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1946

Query: 459  DLETRKKMENQYQREMMAMEEAEELLKRA---GERSAVECSNLLRTLHGLEQEHLRKSLA 515
            +   R++ E + Q+ + A EEA    K A    ER   +     R     EQE  R+ L 
Sbjct: 1947 EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ-LQ 2005

Query: 516  LQQEEDFAKAHRQLAVFQRNELHSIFFTQIKSAIFKGELKPEAAKMLLQNYSKIQENVEE 575
            L QE     A ++L   Q  E    F  Q K        + E  + L Q  S + +   E
Sbjct: 2006 LAQEA----AQKRL---QAEEKAHAFAVQQK--------EQELQQTLQQEQSVLDQLRGE 2050

Query: 576  LMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDE 635
                 +A++    ++    RE      Q  E   + L  +A  Q     Q    A  L +
Sbjct: 2051 AEAARRAAEEAEEARVQAEREAAQSRRQVEEA--ERLKQSAEEQAQARAQAQAAAEKLRK 2108

Query: 636  DQMEMLLERAQTEVFSIKQKLDNDLKQEKKKLHQKLITKRRRELLQKHREQRREQASVGE 695
            +  +    RAQ E  +++QK   D + EK   H+K   +  R+  Q  +E    +  + E
Sbjct: 2109 EAEQEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQTLRQKAQVEQELTTLRLQLEE 2165

Query: 696  AFRTVEDAGQYLHQKRSLMEEHGATLEELQERLDQAALDDLRTLTLSLFEKATDELRRLQ 755
                     + L + ++   E      +++E L    +       L    +A +    L+
Sbjct: 2166 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2225

Query: 756  NSAMTQELLKRGVPWLFLQQILEEHGK-----EMAARAEQLEGEERDRDQEGVQSVRQRL 810
            +   TQ  L+       ++Q+ EE  +     + AAR  QL  EE    Q  +     + 
Sbjct: 2226 DKDNTQRFLQEEAE--KMKQVAEEAARLSVAAQEAARLRQL-AEEDLAQQRALAEKMLKE 2282

Query: 811  KDDAPEAVTEEQAELRRWEHLIFMKLCSSVFSLSEEELLRMRQEVHGCFAQMDRSLALPK 870
            K  A +  T  +AE          +L      L++E+  R++++      Q+       +
Sbjct: 2283 KMQAVQEATRLKAE---------AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQ 2333

Query: 871  IRARVLLQQFQTAWREAEFVKLDQA-VAAPELQQQSKVRKSRSKSKSKGELLKK---CIE 926
                   Q+      EAE +KL  A ++  + + +   ++ R +++  GE L +     +
Sbjct: 2334 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2393

Query: 927  DKIHLCEEQASEDLVEKVRGELLRERVQRMEAQEGGFAQSLVALQF--------QKASRV 978
            +K+ L +    +        E LRE +  +E ++    Q    LQ         Q+   +
Sbjct: 2394 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2453

Query: 979  TETLSAYTALLSIQDLLLEELSASEMLTKSACTQILESHSRELQELERKLEDQLVQQEAA 1038
             ET +   + LS +D LL+     E   K+   Q+ +    + Q+L    E Q  QQ+  
Sbjct: 2454 QETQALQQSFLSEKDSLLQRERFIEQ-EKAKLEQLFQDEVAKAQQLRE--EQQRQQQQME 2510

Query: 1039 QQQQALASWQQWVADGPGILNEPGEVDSERQVSTVLHQALSKSQTLLEQHQQCLREEQ-- 1096
            Q++Q L +                 ++  R+      + + + Q  L+Q +Q  R+++  
Sbjct: 2511 QERQRLVA----------------SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2554

Query: 1097 --QNSVVLEDLLENMEADTFATLCSQELRLASYLARMAMVP 1135
              + +  L + L+ +E    A L   E   AS +A    +P
Sbjct: 2555 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2595


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 73.9 bits (180), Expect = 9e-13
 Identities = 203/874 (23%), Positives = 344/874 (39%), Gaps = 139/874 (15%)

Query: 370  SEDP-GSMLQALEELEIATLNRADADLEACRTQISKDIIALLLKNLTSSGHLSPQVERKM 428
            S DP G+ LQ     +        AD +A R Q+ ++    LL+ +   G    + +R  
Sbjct: 1352 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE--QALLEEIERHGEKVEECQR-- 1407

Query: 429  SAVFKKQFLLLENEIQEEYDRKMVALTAECD--LETRKKMENQYQREMMAMEEAEELLKR 486
               F KQ++   N I++ Y+ ++V   A+ +      KK + Q   E +  E  +  L+ 
Sbjct: 1408 ---FAKQYI---NAIKD-YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD--LRT 1458

Query: 487  AGERSAVECSNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVFQRNELHSIFFTQIK 546
                     S  ++ +     E LR+   +++EE  A+  R     +  E+ +    Q +
Sbjct: 1459 HYSELTTLTSQYIKFI----SETLRR---MEEEERLAEQQRAEERERLAEVEAALEKQRQ 1511

Query: 547  SAIFKGELKPEAAKMLLQNYSKIQENV---EELMDFFQASKRYHLSKRFGHREYLVQNLQ 603
             A    + K +A +   +   ++QE V   EE     Q  KR         +E L Q  Q
Sbjct: 1512 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR-------SIQEELQQLRQ 1564

Query: 604  SSETRVQGLLSTA-AAQLTHL-IQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLK 661
            SSE  +Q     A AA+ + L I++  R   L  +  E     A+ E+ +++ + +    
Sbjct: 1565 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEE--A 1622

Query: 662  QEKKKLHQKLITKRRRELLQKHREQRREQASVGEAFRTVEDAGQYLHQKRSL--MEEHGA 719
            + +K+  Q+   + RR++  +   QR+ QA V  A R   +A     ++R+L  +EE   
Sbjct: 1623 EAQKRQAQEEAERLRRQV--QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1680

Query: 720  TLEELQERLDQAALDDLRTLTLSL-----------------FEKATDELRR-LQNSAMTQ 761
              EE + RL QA ++  R + ++L                 F + T +L R LQ   +  
Sbjct: 1681 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1740

Query: 762  ELLKRGVPWLFLQQILEEHGKEMAARAEQ-------------LEGEERDRDQEGVQSVRQ 808
              L+        QQ   E  +E A R  +             L+ EE  + +   Q+  +
Sbjct: 1741 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1800

Query: 809  RLKDDAPEAV-----TEEQAELRRWEHLIFMKLCSSVFSLSEEELLRMRQEVHGCFAQ-M 862
            + K++A          EEQA  +R               L+E+EL + RQ   G   Q +
Sbjct: 1801 KQKEEAEREARRRGKAEEQAVRQR--------------ELAEQELEKQRQLAEGTAQQRL 1846

Query: 863  DRSLALPKIRARVLLQQFQTAWREAEFVKLDQAVAAPELQQQSKVRKSRSKSKSKGELLK 922
                 L ++RA     + Q    E E  +L Q  AA   Q++ ++    +K +++ E+L 
Sbjct: 1847 AAEQELIRLRAETEQGEQQRQLLEEELARL-QREAAAATQKRQELEAELAKVRAEMEVL- 1904

Query: 923  KCIEDKIHLCEEQASEDLVEKVRGELLRERVQRMEAQEGGF------AQSLVAL-QFQKA 975
              +  K    EE  S     K          QR+EA+ G F      A  L AL +  K 
Sbjct: 1905 --LASKARAEEESRSTSEKSK----------QRLEAEAGRFRELAEEAARLRALAEEAKR 1952

Query: 976  SRVTETLSAYTALLSIQDLLLEELSASEMLT--KSACTQILESHSRELQELERKLEDQLV 1033
             R      A       + +L E+L+A    T  K+     L+    E + L R  ED+  
Sbjct: 1953 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 2012

Query: 1034 QQEAAQQQQALASWQQWVADGPGILNEPGEVDSERQVSTVLHQALSKSQTLLEQHQQCLR 1093
            Q+   ++Q   A  +  + +    L +  + + ERQ   V               +  LR
Sbjct: 2013 QRRRLEEQ--AAQHKADIEERLAQLRKASDSELERQKGLV---------------EDTLR 2055

Query: 1094 EEQQNSVVLEDLLENMEADTFATLCSQELRLASYLARMAMVPGATLRRLLSVVLPTASQP 1153
            + +Q   V E++L    +   A     EL L   L R+      TLR      L  A Q 
Sbjct: 2056 QRRQ---VEEEILALKASFEKAAAGKAELELE--LGRIRSNAEDTLRSKEQAELEAARQR 2110

Query: 1154 QLLALLDSATERHVDHAAESDGGAEQADVGRRRK 1187
            Q LA  +    R  +   +    AE+ +  R+RK
Sbjct: 2111 Q-LAAEEERRRREAEERVQKSLAAEE-EAARQRK 2142



 Score = 67.8 bits (164), Expect = 7e-11
 Identities = 156/761 (20%), Positives = 291/761 (38%), Gaps = 77/761 (10%)

Query: 399  RTQISKDIIALLLKNLTSSGHLSPQVERKMSAVFKKQFLLLENEIQEEYDRKMVALTAEC 458
            R Q+ ++I+AL   +   +     ++E ++  +       L ++ Q E +       A  
Sbjct: 2057 RRQVEEEILALKA-SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 2115

Query: 459  DLETRKKMENQYQREMMAMEEAEELLKRA---GERSAVECSNLLRTLHGLEQEHLRKSLA 515
            +   R++ E + Q+ + A EEA    K A    ER   +     R     EQE  R+ L 
Sbjct: 2116 EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ-LQ 2174

Query: 516  LQQEEDFAKAHRQLAVFQRNELHSIFFTQIKSAIFKGELKPEAAKMLLQNYSKIQENVEE 575
            L QE     A ++L   Q  E    F  Q K        + E  + L Q  S + +   E
Sbjct: 2175 LAQEA----AQKRL---QAEEKAHAFAVQQK--------EQELQQTLQQEQSVLDQLRGE 2219

Query: 576  LMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDE 635
                 +A++    ++    RE      Q  E   + L  +A  Q     Q    A  L +
Sbjct: 2220 AEAARRAAEEAEEARVQAEREAAQSRRQVEEA--ERLKQSAEEQAQARAQAQAAAEKLRK 2277

Query: 636  DQMEMLLERAQTEVFSIKQKLDNDLKQEKKKLHQKLITKRRRELLQKHREQRREQASVGE 695
            +  +    RAQ E  +++QK   D + EK   H+K   +  R+  Q  +E    +  + E
Sbjct: 2278 EAEQEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQTLRQKAQVEQELTTLRLQLEE 2334

Query: 696  AFRTVEDAGQYLHQKRSLMEEHGATLEELQERLDQAALDDLRTLTLSLFEKATDELRRLQ 755
                     + L + ++   E      +++E L    +       L    +A +    L+
Sbjct: 2335 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2394

Query: 756  NSAMTQELLKRGVPWLFLQQILEEHGK-----EMAARAEQLEGEERDRDQEGVQSVRQRL 810
            +   TQ  L+       ++Q+ EE  +     + AAR  QL  EE    Q  +     + 
Sbjct: 2395 DKDNTQRFLQEEAE--KMKQVAEEAARLSVAAQEAARLRQL-AEEDLAQQRALAEKMLKE 2451

Query: 811  KDDAPEAVTEEQAELRRWEHLIFMKLCSSVFSLSEEELLRMRQEVHGCFAQMDRSLALPK 870
            K  A +  T  +AE          +L      L++E+  R++++      Q+       +
Sbjct: 2452 KMQAVQEATRLKAE---------AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQ 2502

Query: 871  IRARVLLQQFQTAWREAEFVKLDQA-VAAPELQQQSKVRKSRSKSKSKGELLKK---CIE 926
                   Q+      EAE +KL  A ++  + + +   ++ R +++  GE L +     +
Sbjct: 2503 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2562

Query: 927  DKIHLCEEQASEDLVEKVRGELLRERVQRMEAQEGGFAQSLVALQF--------QKASRV 978
            +K+ L +    +        E LRE +  +E ++    Q    LQ         Q+   +
Sbjct: 2563 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2622

Query: 979  TETLSAYTALLSIQDLLLEELSASEMLTKSACTQILESHSRELQELERKLEDQLVQQEAA 1038
             ET +   + LS +D LL+     E   K+   Q+ +    + Q+L    E Q  QQ+  
Sbjct: 2623 QETQALQQSFLSEKDSLLQRERFIEQ-EKAKLEQLFQDEVAKAQQLRE--EQQRQQQQME 2679

Query: 1039 QQQQALASWQQWVADGPGILNEPGEVDSERQVSTVLHQALSKSQTLLEQHQQCLREEQ-- 1096
            Q++Q L +                 ++  R+      + + + Q  L+Q +Q  R+++  
Sbjct: 2680 QERQRLVA----------------SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2723

Query: 1097 --QNSVVLEDLLENMEADTFATLCSQELRLASYLARMAMVP 1135
              + +  L + L+ +E    A L   E   AS +A    +P
Sbjct: 2724 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2764


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 73.9 bits (180), Expect = 9e-13
 Identities = 203/874 (23%), Positives = 344/874 (39%), Gaps = 139/874 (15%)

Query: 370  SEDP-GSMLQALEELEIATLNRADADLEACRTQISKDIIALLLKNLTSSGHLSPQVERKM 428
            S DP G+ LQ     +        AD +A R Q+ ++    LL+ +   G    + +R  
Sbjct: 1193 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE--QALLEEIERHGEKVEECQR-- 1248

Query: 429  SAVFKKQFLLLENEIQEEYDRKMVALTAECD--LETRKKMENQYQREMMAMEEAEELLKR 486
               F KQ++   N I++ Y+ ++V   A+ +      KK + Q   E +  E  +  L+ 
Sbjct: 1249 ---FAKQYI---NAIKD-YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD--LRT 1299

Query: 487  AGERSAVECSNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVFQRNELHSIFFTQIK 546
                     S  ++ +     E LR+   +++EE  A+  R     +  E+ +    Q +
Sbjct: 1300 HYSELTTLTSQYIKFI----SETLRR---MEEEERLAEQQRAEERERLAEVEAALEKQRQ 1352

Query: 547  SAIFKGELKPEAAKMLLQNYSKIQENV---EELMDFFQASKRYHLSKRFGHREYLVQNLQ 603
             A    + K +A +   +   ++QE V   EE     Q  KR         +E L Q  Q
Sbjct: 1353 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR-------SIQEELQQLRQ 1405

Query: 604  SSETRVQGLLSTA-AAQLTHL-IQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLK 661
            SSE  +Q     A AA+ + L I++  R   L  +  E     A+ E+ +++ + +    
Sbjct: 1406 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEE--A 1463

Query: 662  QEKKKLHQKLITKRRRELLQKHREQRREQASVGEAFRTVEDAGQYLHQKRSL--MEEHGA 719
            + +K+  Q+   + RR++  +   QR+ QA V  A R   +A     ++R+L  +EE   
Sbjct: 1464 EAQKRQAQEEAERLRRQV--QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1521

Query: 720  TLEELQERLDQAALDDLRTLTLSL-----------------FEKATDELRR-LQNSAMTQ 761
              EE + RL QA ++  R + ++L                 F + T +L R LQ   +  
Sbjct: 1522 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1581

Query: 762  ELLKRGVPWLFLQQILEEHGKEMAARAEQ-------------LEGEERDRDQEGVQSVRQ 808
              L+        QQ   E  +E A R  +             L+ EE  + +   Q+  +
Sbjct: 1582 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1641

Query: 809  RLKDDAPEAV-----TEEQAELRRWEHLIFMKLCSSVFSLSEEELLRMRQEVHGCFAQ-M 862
            + K++A          EEQA  +R               L+E+EL + RQ   G   Q +
Sbjct: 1642 KQKEEAEREARRRGKAEEQAVRQR--------------ELAEQELEKQRQLAEGTAQQRL 1687

Query: 863  DRSLALPKIRARVLLQQFQTAWREAEFVKLDQAVAAPELQQQSKVRKSRSKSKSKGELLK 922
                 L ++RA     + Q    E E  +L Q  AA   Q++ ++    +K +++ E+L 
Sbjct: 1688 AAEQELIRLRAETEQGEQQRQLLEEELARL-QREAAAATQKRQELEAELAKVRAEMEVL- 1745

Query: 923  KCIEDKIHLCEEQASEDLVEKVRGELLRERVQRMEAQEGGF------AQSLVAL-QFQKA 975
              +  K    EE  S     K          QR+EA+ G F      A  L AL +  K 
Sbjct: 1746 --LASKARAEEESRSTSEKSK----------QRLEAEAGRFRELAEEAARLRALAEEAKR 1793

Query: 976  SRVTETLSAYTALLSIQDLLLEELSASEMLT--KSACTQILESHSRELQELERKLEDQLV 1033
             R      A       + +L E+L+A    T  K+     L+    E + L R  ED+  
Sbjct: 1794 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1853

Query: 1034 QQEAAQQQQALASWQQWVADGPGILNEPGEVDSERQVSTVLHQALSKSQTLLEQHQQCLR 1093
            Q+   ++Q   A  +  + +    L +  + + ERQ   V               +  LR
Sbjct: 1854 QRRRLEEQ--AAQHKADIEERLAQLRKASDSELERQKGLV---------------EDTLR 1896

Query: 1094 EEQQNSVVLEDLLENMEADTFATLCSQELRLASYLARMAMVPGATLRRLLSVVLPTASQP 1153
            + +Q   V E++L    +   A     EL L   L R+      TLR      L  A Q 
Sbjct: 1897 QRRQ---VEEEILALKASFEKAAAGKAELELE--LGRIRSNAEDTLRSKEQAELEAARQR 1951

Query: 1154 QLLALLDSATERHVDHAAESDGGAEQADVGRRRK 1187
            Q LA  +    R  +   +    AE+ +  R+RK
Sbjct: 1952 Q-LAAEEERRRREAEERVQKSLAAEE-EAARQRK 1983



 Score = 67.8 bits (164), Expect = 7e-11
 Identities = 156/761 (20%), Positives = 291/761 (38%), Gaps = 77/761 (10%)

Query: 399  RTQISKDIIALLLKNLTSSGHLSPQVERKMSAVFKKQFLLLENEIQEEYDRKMVALTAEC 458
            R Q+ ++I+AL   +   +     ++E ++  +       L ++ Q E +       A  
Sbjct: 1898 RRQVEEEILALKA-SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1956

Query: 459  DLETRKKMENQYQREMMAMEEAEELLKRA---GERSAVECSNLLRTLHGLEQEHLRKSLA 515
            +   R++ E + Q+ + A EEA    K A    ER   +     R     EQE  R+ L 
Sbjct: 1957 EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ-LQ 2015

Query: 516  LQQEEDFAKAHRQLAVFQRNELHSIFFTQIKSAIFKGELKPEAAKMLLQNYSKIQENVEE 575
            L QE     A ++L   Q  E    F  Q K        + E  + L Q  S + +   E
Sbjct: 2016 LAQEA----AQKRL---QAEEKAHAFAVQQK--------EQELQQTLQQEQSVLDQLRGE 2060

Query: 576  LMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDE 635
                 +A++    ++    RE      Q  E   + L  +A  Q     Q    A  L +
Sbjct: 2061 AEAARRAAEEAEEARVQAEREAAQSRRQVEEA--ERLKQSAEEQAQARAQAQAAAEKLRK 2118

Query: 636  DQMEMLLERAQTEVFSIKQKLDNDLKQEKKKLHQKLITKRRRELLQKHREQRREQASVGE 695
            +  +    RAQ E  +++QK   D + EK   H+K   +  R+  Q  +E    +  + E
Sbjct: 2119 EAEQEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQTLRQKAQVEQELTTLRLQLEE 2175

Query: 696  AFRTVEDAGQYLHQKRSLMEEHGATLEELQERLDQAALDDLRTLTLSLFEKATDELRRLQ 755
                     + L + ++   E      +++E L    +       L    +A +    L+
Sbjct: 2176 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2235

Query: 756  NSAMTQELLKRGVPWLFLQQILEEHGK-----EMAARAEQLEGEERDRDQEGVQSVRQRL 810
            +   TQ  L+       ++Q+ EE  +     + AAR  QL  EE    Q  +     + 
Sbjct: 2236 DKDNTQRFLQEEAE--KMKQVAEEAARLSVAAQEAARLRQL-AEEDLAQQRALAEKMLKE 2292

Query: 811  KDDAPEAVTEEQAELRRWEHLIFMKLCSSVFSLSEEELLRMRQEVHGCFAQMDRSLALPK 870
            K  A +  T  +AE          +L      L++E+  R++++      Q+       +
Sbjct: 2293 KMQAVQEATRLKAE---------AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQ 2343

Query: 871  IRARVLLQQFQTAWREAEFVKLDQA-VAAPELQQQSKVRKSRSKSKSKGELLKK---CIE 926
                   Q+      EAE +KL  A ++  + + +   ++ R +++  GE L +     +
Sbjct: 2344 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2403

Query: 927  DKIHLCEEQASEDLVEKVRGELLRERVQRMEAQEGGFAQSLVALQF--------QKASRV 978
            +K+ L +    +        E LRE +  +E ++    Q    LQ         Q+   +
Sbjct: 2404 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2463

Query: 979  TETLSAYTALLSIQDLLLEELSASEMLTKSACTQILESHSRELQELERKLEDQLVQQEAA 1038
             ET +   + LS +D LL+     E   K+   Q+ +    + Q+L    E Q  QQ+  
Sbjct: 2464 QETQALQQSFLSEKDSLLQRERFIEQ-EKAKLEQLFQDEVAKAQQLRE--EQQRQQQQME 2520

Query: 1039 QQQQALASWQQWVADGPGILNEPGEVDSERQVSTVLHQALSKSQTLLEQHQQCLREEQ-- 1096
            Q++Q L +                 ++  R+      + + + Q  L+Q +Q  R+++  
Sbjct: 2521 QERQRLVA----------------SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2564

Query: 1097 --QNSVVLEDLLENMEADTFATLCSQELRLASYLARMAMVP 1135
              + +  L + L+ +E    A L   E   AS +A    +P
Sbjct: 2565 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2605


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 73.9 bits (180), Expect = 9e-13
 Identities = 203/874 (23%), Positives = 344/874 (39%), Gaps = 139/874 (15%)

Query: 370  SEDP-GSMLQALEELEIATLNRADADLEACRTQISKDIIALLLKNLTSSGHLSPQVERKM 428
            S DP G+ LQ     +        AD +A R Q+ ++    LL+ +   G    + +R  
Sbjct: 1201 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE--QALLEEIERHGEKVEECQR-- 1256

Query: 429  SAVFKKQFLLLENEIQEEYDRKMVALTAECD--LETRKKMENQYQREMMAMEEAEELLKR 486
               F KQ++   N I++ Y+ ++V   A+ +      KK + Q   E +  E  +  L+ 
Sbjct: 1257 ---FAKQYI---NAIKD-YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD--LRT 1307

Query: 487  AGERSAVECSNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVFQRNELHSIFFTQIK 546
                     S  ++ +     E LR+   +++EE  A+  R     +  E+ +    Q +
Sbjct: 1308 HYSELTTLTSQYIKFI----SETLRR---MEEEERLAEQQRAEERERLAEVEAALEKQRQ 1360

Query: 547  SAIFKGELKPEAAKMLLQNYSKIQENV---EELMDFFQASKRYHLSKRFGHREYLVQNLQ 603
             A    + K +A +   +   ++QE V   EE     Q  KR         +E L Q  Q
Sbjct: 1361 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR-------SIQEELQQLRQ 1413

Query: 604  SSETRVQGLLSTA-AAQLTHL-IQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLK 661
            SSE  +Q     A AA+ + L I++  R   L  +  E     A+ E+ +++ + +    
Sbjct: 1414 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEE--A 1471

Query: 662  QEKKKLHQKLITKRRRELLQKHREQRREQASVGEAFRTVEDAGQYLHQKRSL--MEEHGA 719
            + +K+  Q+   + RR++  +   QR+ QA V  A R   +A     ++R+L  +EE   
Sbjct: 1472 EAQKRQAQEEAERLRRQV--QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1529

Query: 720  TLEELQERLDQAALDDLRTLTLSL-----------------FEKATDELRR-LQNSAMTQ 761
              EE + RL QA ++  R + ++L                 F + T +L R LQ   +  
Sbjct: 1530 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1589

Query: 762  ELLKRGVPWLFLQQILEEHGKEMAARAEQ-------------LEGEERDRDQEGVQSVRQ 808
              L+        QQ   E  +E A R  +             L+ EE  + +   Q+  +
Sbjct: 1590 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1649

Query: 809  RLKDDAPEAV-----TEEQAELRRWEHLIFMKLCSSVFSLSEEELLRMRQEVHGCFAQ-M 862
            + K++A          EEQA  +R               L+E+EL + RQ   G   Q +
Sbjct: 1650 KQKEEAEREARRRGKAEEQAVRQR--------------ELAEQELEKQRQLAEGTAQQRL 1695

Query: 863  DRSLALPKIRARVLLQQFQTAWREAEFVKLDQAVAAPELQQQSKVRKSRSKSKSKGELLK 922
                 L ++RA     + Q    E E  +L Q  AA   Q++ ++    +K +++ E+L 
Sbjct: 1696 AAEQELIRLRAETEQGEQQRQLLEEELARL-QREAAAATQKRQELEAELAKVRAEMEVL- 1753

Query: 923  KCIEDKIHLCEEQASEDLVEKVRGELLRERVQRMEAQEGGF------AQSLVAL-QFQKA 975
              +  K    EE  S     K          QR+EA+ G F      A  L AL +  K 
Sbjct: 1754 --LASKARAEEESRSTSEKSK----------QRLEAEAGRFRELAEEAARLRALAEEAKR 1801

Query: 976  SRVTETLSAYTALLSIQDLLLEELSASEMLT--KSACTQILESHSRELQELERKLEDQLV 1033
             R      A       + +L E+L+A    T  K+     L+    E + L R  ED+  
Sbjct: 1802 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1861

Query: 1034 QQEAAQQQQALASWQQWVADGPGILNEPGEVDSERQVSTVLHQALSKSQTLLEQHQQCLR 1093
            Q+   ++Q   A  +  + +    L +  + + ERQ   V               +  LR
Sbjct: 1862 QRRRLEEQ--AAQHKADIEERLAQLRKASDSELERQKGLV---------------EDTLR 1904

Query: 1094 EEQQNSVVLEDLLENMEADTFATLCSQELRLASYLARMAMVPGATLRRLLSVVLPTASQP 1153
            + +Q   V E++L    +   A     EL L   L R+      TLR      L  A Q 
Sbjct: 1905 QRRQ---VEEEILALKASFEKAAAGKAELELE--LGRIRSNAEDTLRSKEQAELEAARQR 1959

Query: 1154 QLLALLDSATERHVDHAAESDGGAEQADVGRRRK 1187
            Q LA  +    R  +   +    AE+ +  R+RK
Sbjct: 1960 Q-LAAEEERRRREAEERVQKSLAAEE-EAARQRK 1991



 Score = 67.8 bits (164), Expect = 7e-11
 Identities = 156/761 (20%), Positives = 291/761 (38%), Gaps = 77/761 (10%)

Query: 399  RTQISKDIIALLLKNLTSSGHLSPQVERKMSAVFKKQFLLLENEIQEEYDRKMVALTAEC 458
            R Q+ ++I+AL   +   +     ++E ++  +       L ++ Q E +       A  
Sbjct: 1906 RRQVEEEILALKA-SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1964

Query: 459  DLETRKKMENQYQREMMAMEEAEELLKRA---GERSAVECSNLLRTLHGLEQEHLRKSLA 515
            +   R++ E + Q+ + A EEA    K A    ER   +     R     EQE  R+ L 
Sbjct: 1965 EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ-LQ 2023

Query: 516  LQQEEDFAKAHRQLAVFQRNELHSIFFTQIKSAIFKGELKPEAAKMLLQNYSKIQENVEE 575
            L QE     A ++L   Q  E    F  Q K        + E  + L Q  S + +   E
Sbjct: 2024 LAQEA----AQKRL---QAEEKAHAFAVQQK--------EQELQQTLQQEQSVLDQLRGE 2068

Query: 576  LMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDE 635
                 +A++    ++    RE      Q  E   + L  +A  Q     Q    A  L +
Sbjct: 2069 AEAARRAAEEAEEARVQAEREAAQSRRQVEEA--ERLKQSAEEQAQARAQAQAAAEKLRK 2126

Query: 636  DQMEMLLERAQTEVFSIKQKLDNDLKQEKKKLHQKLITKRRRELLQKHREQRREQASVGE 695
            +  +    RAQ E  +++QK   D + EK   H+K   +  R+  Q  +E    +  + E
Sbjct: 2127 EAEQEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQTLRQKAQVEQELTTLRLQLEE 2183

Query: 696  AFRTVEDAGQYLHQKRSLMEEHGATLEELQERLDQAALDDLRTLTLSLFEKATDELRRLQ 755
                     + L + ++   E      +++E L    +       L    +A +    L+
Sbjct: 2184 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2243

Query: 756  NSAMTQELLKRGVPWLFLQQILEEHGK-----EMAARAEQLEGEERDRDQEGVQSVRQRL 810
            +   TQ  L+       ++Q+ EE  +     + AAR  QL  EE    Q  +     + 
Sbjct: 2244 DKDNTQRFLQEEAE--KMKQVAEEAARLSVAAQEAARLRQL-AEEDLAQQRALAEKMLKE 2300

Query: 811  KDDAPEAVTEEQAELRRWEHLIFMKLCSSVFSLSEEELLRMRQEVHGCFAQMDRSLALPK 870
            K  A +  T  +AE          +L      L++E+  R++++      Q+       +
Sbjct: 2301 KMQAVQEATRLKAE---------AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQ 2351

Query: 871  IRARVLLQQFQTAWREAEFVKLDQA-VAAPELQQQSKVRKSRSKSKSKGELLKK---CIE 926
                   Q+      EAE +KL  A ++  + + +   ++ R +++  GE L +     +
Sbjct: 2352 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2411

Query: 927  DKIHLCEEQASEDLVEKVRGELLRERVQRMEAQEGGFAQSLVALQF--------QKASRV 978
            +K+ L +    +        E LRE +  +E ++    Q    LQ         Q+   +
Sbjct: 2412 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2471

Query: 979  TETLSAYTALLSIQDLLLEELSASEMLTKSACTQILESHSRELQELERKLEDQLVQQEAA 1038
             ET +   + LS +D LL+     E   K+   Q+ +    + Q+L    E Q  QQ+  
Sbjct: 2472 QETQALQQSFLSEKDSLLQRERFIEQ-EKAKLEQLFQDEVAKAQQLRE--EQQRQQQQME 2528

Query: 1039 QQQQALASWQQWVADGPGILNEPGEVDSERQVSTVLHQALSKSQTLLEQHQQCLREEQ-- 1096
            Q++Q L +                 ++  R+      + + + Q  L+Q +Q  R+++  
Sbjct: 2529 QERQRLVA----------------SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2572

Query: 1097 --QNSVVLEDLLENMEADTFATLCSQELRLASYLARMAMVP 1135
              + +  L + L+ +E    A L   E   AS +A    +P
Sbjct: 2573 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2613


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 73.9 bits (180), Expect = 9e-13
 Identities = 203/874 (23%), Positives = 344/874 (39%), Gaps = 139/874 (15%)

Query: 370  SEDP-GSMLQALEELEIATLNRADADLEACRTQISKDIIALLLKNLTSSGHLSPQVERKM 428
            S DP G+ LQ     +        AD +A R Q+ ++    LL+ +   G    + +R  
Sbjct: 1242 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE--QALLEEIERHGEKVEECQR-- 1297

Query: 429  SAVFKKQFLLLENEIQEEYDRKMVALTAECD--LETRKKMENQYQREMMAMEEAEELLKR 486
               F KQ++   N I++ Y+ ++V   A+ +      KK + Q   E +  E  +  L+ 
Sbjct: 1298 ---FAKQYI---NAIKD-YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD--LRT 1348

Query: 487  AGERSAVECSNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVFQRNELHSIFFTQIK 546
                     S  ++ +     E LR+   +++EE  A+  R     +  E+ +    Q +
Sbjct: 1349 HYSELTTLTSQYIKFI----SETLRR---MEEEERLAEQQRAEERERLAEVEAALEKQRQ 1401

Query: 547  SAIFKGELKPEAAKMLLQNYSKIQENV---EELMDFFQASKRYHLSKRFGHREYLVQNLQ 603
             A    + K +A +   +   ++QE V   EE     Q  KR         +E L Q  Q
Sbjct: 1402 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR-------SIQEELQQLRQ 1454

Query: 604  SSETRVQGLLSTA-AAQLTHL-IQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLK 661
            SSE  +Q     A AA+ + L I++  R   L  +  E     A+ E+ +++ + +    
Sbjct: 1455 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEE--A 1512

Query: 662  QEKKKLHQKLITKRRRELLQKHREQRREQASVGEAFRTVEDAGQYLHQKRSL--MEEHGA 719
            + +K+  Q+   + RR++  +   QR+ QA V  A R   +A     ++R+L  +EE   
Sbjct: 1513 EAQKRQAQEEAERLRRQV--QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1570

Query: 720  TLEELQERLDQAALDDLRTLTLSL-----------------FEKATDELRR-LQNSAMTQ 761
              EE + RL QA ++  R + ++L                 F + T +L R LQ   +  
Sbjct: 1571 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1630

Query: 762  ELLKRGVPWLFLQQILEEHGKEMAARAEQ-------------LEGEERDRDQEGVQSVRQ 808
              L+        QQ   E  +E A R  +             L+ EE  + +   Q+  +
Sbjct: 1631 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1690

Query: 809  RLKDDAPEAV-----TEEQAELRRWEHLIFMKLCSSVFSLSEEELLRMRQEVHGCFAQ-M 862
            + K++A          EEQA  +R               L+E+EL + RQ   G   Q +
Sbjct: 1691 KQKEEAEREARRRGKAEEQAVRQR--------------ELAEQELEKQRQLAEGTAQQRL 1736

Query: 863  DRSLALPKIRARVLLQQFQTAWREAEFVKLDQAVAAPELQQQSKVRKSRSKSKSKGELLK 922
                 L ++RA     + Q    E E  +L Q  AA   Q++ ++    +K +++ E+L 
Sbjct: 1737 AAEQELIRLRAETEQGEQQRQLLEEELARL-QREAAAATQKRQELEAELAKVRAEMEVL- 1794

Query: 923  KCIEDKIHLCEEQASEDLVEKVRGELLRERVQRMEAQEGGF------AQSLVAL-QFQKA 975
              +  K    EE  S     K          QR+EA+ G F      A  L AL +  K 
Sbjct: 1795 --LASKARAEEESRSTSEKSK----------QRLEAEAGRFRELAEEAARLRALAEEAKR 1842

Query: 976  SRVTETLSAYTALLSIQDLLLEELSASEMLT--KSACTQILESHSRELQELERKLEDQLV 1033
             R      A       + +L E+L+A    T  K+     L+    E + L R  ED+  
Sbjct: 1843 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1902

Query: 1034 QQEAAQQQQALASWQQWVADGPGILNEPGEVDSERQVSTVLHQALSKSQTLLEQHQQCLR 1093
            Q+   ++Q   A  +  + +    L +  + + ERQ   V               +  LR
Sbjct: 1903 QRRRLEEQ--AAQHKADIEERLAQLRKASDSELERQKGLV---------------EDTLR 1945

Query: 1094 EEQQNSVVLEDLLENMEADTFATLCSQELRLASYLARMAMVPGATLRRLLSVVLPTASQP 1153
            + +Q   V E++L    +   A     EL L   L R+      TLR      L  A Q 
Sbjct: 1946 QRRQ---VEEEILALKASFEKAAAGKAELELE--LGRIRSNAEDTLRSKEQAELEAARQR 2000

Query: 1154 QLLALLDSATERHVDHAAESDGGAEQADVGRRRK 1187
            Q LA  +    R  +   +    AE+ +  R+RK
Sbjct: 2001 Q-LAAEEERRRREAEERVQKSLAAEE-EAARQRK 2032



 Score = 67.8 bits (164), Expect = 7e-11
 Identities = 156/761 (20%), Positives = 291/761 (38%), Gaps = 77/761 (10%)

Query: 399  RTQISKDIIALLLKNLTSSGHLSPQVERKMSAVFKKQFLLLENEIQEEYDRKMVALTAEC 458
            R Q+ ++I+AL   +   +     ++E ++  +       L ++ Q E +       A  
Sbjct: 1947 RRQVEEEILALKA-SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 2005

Query: 459  DLETRKKMENQYQREMMAMEEAEELLKRA---GERSAVECSNLLRTLHGLEQEHLRKSLA 515
            +   R++ E + Q+ + A EEA    K A    ER   +     R     EQE  R+ L 
Sbjct: 2006 EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ-LQ 2064

Query: 516  LQQEEDFAKAHRQLAVFQRNELHSIFFTQIKSAIFKGELKPEAAKMLLQNYSKIQENVEE 575
            L QE     A ++L   Q  E    F  Q K        + E  + L Q  S + +   E
Sbjct: 2065 LAQEA----AQKRL---QAEEKAHAFAVQQK--------EQELQQTLQQEQSVLDQLRGE 2109

Query: 576  LMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDE 635
                 +A++    ++    RE      Q  E   + L  +A  Q     Q    A  L +
Sbjct: 2110 AEAARRAAEEAEEARVQAEREAAQSRRQVEEA--ERLKQSAEEQAQARAQAQAAAEKLRK 2167

Query: 636  DQMEMLLERAQTEVFSIKQKLDNDLKQEKKKLHQKLITKRRRELLQKHREQRREQASVGE 695
            +  +    RAQ E  +++QK   D + EK   H+K   +  R+  Q  +E    +  + E
Sbjct: 2168 EAEQEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQTLRQKAQVEQELTTLRLQLEE 2224

Query: 696  AFRTVEDAGQYLHQKRSLMEEHGATLEELQERLDQAALDDLRTLTLSLFEKATDELRRLQ 755
                     + L + ++   E      +++E L    +       L    +A +    L+
Sbjct: 2225 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2284

Query: 756  NSAMTQELLKRGVPWLFLQQILEEHGK-----EMAARAEQLEGEERDRDQEGVQSVRQRL 810
            +   TQ  L+       ++Q+ EE  +     + AAR  QL  EE    Q  +     + 
Sbjct: 2285 DKDNTQRFLQEEAE--KMKQVAEEAARLSVAAQEAARLRQL-AEEDLAQQRALAEKMLKE 2341

Query: 811  KDDAPEAVTEEQAELRRWEHLIFMKLCSSVFSLSEEELLRMRQEVHGCFAQMDRSLALPK 870
            K  A +  T  +AE          +L      L++E+  R++++      Q+       +
Sbjct: 2342 KMQAVQEATRLKAE---------AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQ 2392

Query: 871  IRARVLLQQFQTAWREAEFVKLDQA-VAAPELQQQSKVRKSRSKSKSKGELLKK---CIE 926
                   Q+      EAE +KL  A ++  + + +   ++ R +++  GE L +     +
Sbjct: 2393 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2452

Query: 927  DKIHLCEEQASEDLVEKVRGELLRERVQRMEAQEGGFAQSLVALQF--------QKASRV 978
            +K+ L +    +        E LRE +  +E ++    Q    LQ         Q+   +
Sbjct: 2453 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2512

Query: 979  TETLSAYTALLSIQDLLLEELSASEMLTKSACTQILESHSRELQELERKLEDQLVQQEAA 1038
             ET +   + LS +D LL+     E   K+   Q+ +    + Q+L    E Q  QQ+  
Sbjct: 2513 QETQALQQSFLSEKDSLLQRERFIEQ-EKAKLEQLFQDEVAKAQQLRE--EQQRQQQQME 2569

Query: 1039 QQQQALASWQQWVADGPGILNEPGEVDSERQVSTVLHQALSKSQTLLEQHQQCLREEQ-- 1096
            Q++Q L +                 ++  R+      + + + Q  L+Q +Q  R+++  
Sbjct: 2570 QERQRLVA----------------SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2613

Query: 1097 --QNSVVLEDLLENMEADTFATLCSQELRLASYLARMAMVP 1135
              + +  L + L+ +E    A L   E   AS +A    +P
Sbjct: 2614 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2654


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 210/880 (23%), Positives = 359/880 (40%), Gaps = 134/880 (15%)

Query: 379  ALEELEIATLNRADADLEACRTQISKDIIALLLKNLTSSGHLSPQVERKMSAVFKKQFLL 438
            A  E E+ TL     +LE  R ++ K  + LL  +L          + ++  + K + +L
Sbjct: 1431 AEREEEVETLRGQIQELEKQR-EMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVL 1489

Query: 439  --LENEIQEEYDRKMVALTAECDLET-RKKMENQYQREMMAMEEAEELLKRAGERSAVEC 495
              L   +QE   +  V      +LE  R+   N  + +++ +E+ +++++   +R  V+ 
Sbjct: 1490 EHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIE--SQRGQVQ- 1546

Query: 496  SNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVFQRNELHSIFFTQIKSAIFKGELK 555
             +L + L  LE       LAL+ EE+  K   Q                 +  I + E +
Sbjct: 1547 -DLKKQLVTLE------CLALELEENHHKMECQ-----------------QKLIKELEGQ 1582

Query: 556  PEAAKMLLQNYS-KIQENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGL-- 612
             E  ++ L + +  ++E  +EL    Q+S+ + L     H   L + LQ  +  V+    
Sbjct: 1583 RETQRVALTHLTLDLEERSQELQA--QSSQIHDLES---HSTVLARELQERDQEVKSQRE 1637

Query: 613  -LSTAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQK-----LDNDLKQEKKK 666
             +     Q  HL Q  ER      DQ E++L++ + +V   ++      L+ DL+Q K  
Sbjct: 1638 QIEELQRQKEHLTQDLER-----RDQ-ELMLQKERIQVLEDQRTRQTKILEEDLEQIKLS 1691

Query: 667  LHQK---LITKRRRELLQKHREQRREQASVGEAFRTVEDAGQYLHQKRSLME---EHGAT 720
            L ++   L T+R  +L+Q+  E+ +  +       ++E     L  K   +E   EH   
Sbjct: 1692 LRERGRELTTQR--QLMQERAEEGKGPSKAQRG--SLEHMKLILRDKEKEVECQQEHIHE 1747

Query: 721  LEELQERLDQAALDDLR-----TLTLSLFEKATDELRRLQNSAMTQELLKRGVPWLFLQQ 775
            L+EL+++L+Q      R     +L LS  E+    L++    A  Q  LK       LQ 
Sbjct: 1748 LQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQS----LQS 1803

Query: 776  ILEEHGKEMAARAEQLEGEERDRDQEGVQSVRQRLKDDAPEAVTEEQAELRRWEHLIFMK 835
             L+E  + +A R ++LE  ++++ Q   Q  R + K DA +   E+     +  H     
Sbjct: 1804 QLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQD 1863

Query: 836  LCSSVFSLSEEELLRMR-----QEVHGCFAQMDRS-----LALPKIRA------RVLLQQ 879
                   L EE  +  R     +EV G      R      LAL +  A       V  + 
Sbjct: 1864 HKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRA 1923

Query: 880  FQTAWREAEFV--KLDQAVAAPELQQQSKVRKSRSKSKSKGELLKKCIEDKIHLCEEQAS 937
             Q +W +A+ V  + DQ + A   + QS  R     ++++ E L++ +  K H   +   
Sbjct: 1924 LQDSWLQAQAVLKERDQELEALRAESQSS-RHQEEAARARAEALQEAL-GKAHAALQGKE 1981

Query: 938  EDLVEKVRGELLRERVQRMEAQEGGFAQSLVALQFQKASRVTETLSAYTALLSIQDLLLE 997
            + L+E+       E  + +EA       SL A Q   + ++ E L      +  QDL  +
Sbjct: 1982 QHLLEQA------ELSRSLEASTATLQASLDACQ-AHSRQLEEALRIQEGEIQDQDLRYQ 2034

Query: 998  ELSASEMLTKSACTQILESHSRELQELERKLEDQLVQQEAAQQQQALASWQQWVADGPGI 1057
            E    ++    A       H +E ++L  K   Q VQ+   Q++Q L             
Sbjct: 2035 E-DVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQ----------- 2082

Query: 1058 LNEPGEVDSERQVSTVLHQALSKSQTLLEQHQQ---CLREEQQNSVVLEDLLENMEA--- 1111
                   + E +    LHQ++ + Q  L Q +Q    LRE QQ +  LE L  + +    
Sbjct: 2083 -------EREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRN-NLEALPHSHKTSPM 2134

Query: 1112 -DTFATLCSQELRLASYLARMAMVPGATLRRLLSVVLPTASQPQLLALLDSATERHVDHA 1170
             +    L S E RL   L R+     A LR+  +  +    + Q LAL  + T+  V   
Sbjct: 2135 EEQSLKLDSLEPRLQRELERLQ----AALRQTEAREIEWREKAQDLALSLAQTKASVSSL 2190

Query: 1171 AESDGGAEQADVGRRRKHQSWWQALDGKLRGDLISRGLEK 1210
             E      QA V  R   Q   Q L  +L  +L  R LEK
Sbjct: 2191 QEV-AMFLQASVLERDSEQ---QRLQDEL--ELTRRALEK 2224



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 154/706 (21%), Positives = 292/706 (41%), Gaps = 78/706 (11%)

Query: 444  QEEYDRKMVALT-AECDLETRKKMENQYQREMMAMEEAEELLKRAGERSAVECSNLLRTL 502
            Q E +R   A   A+ + E +  +E   Q++    +E  +L ++  +  +     L + L
Sbjct: 821  QAEQERDAAARQLAQAEQEGKTALE---QQKAAHEKEVNQLREKWEKERSWHQQELAKAL 877

Query: 503  HGLEQEHLRKSLALQQEEDFAKAHRQLAVFQRNELHSIFFTQIKSAIFKGELKPEAAKML 562
              LE+E +   + L++++   +A +     QR E      TQ +SA+ + +L+ E  ++ 
Sbjct: 878  ESLEREKMELEMRLKEQQTEMEAIQA----QREEER----TQAESALCQMQLETEKERVS 929

Query: 563  LQNYSKIQENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETR--VQGLLSTAAAQL 620
            L     + +  +EL D  Q  +R         ++  VQ L+  ET   +Q  L  A  +L
Sbjct: 930  L--LETLLQTQKELADASQQLERLR-------QDMKVQKLKEQETTGILQTQLQEAQREL 980

Query: 621  THLIQKH-ERAGYLDEDQMEMLLERA--QTEVFSIKQKL---DNDLKQEKKKLHQKLITK 674
                ++H +    L E+   +L ++   Q +V  +K +L   D+  +  ++++ +KL   
Sbjct: 981  KEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRET 1040

Query: 675  RRRELLQKHREQRREQASVGEAFRTVEDAGQYLHQKRSL-MEEHGATLEELQERL-DQAA 732
            +    +QK  E  RE+AS+  +    E     L +  S+  +E  A  +++QE   +Q  
Sbjct: 1041 QEYNRIQKELE--REKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKE 1098

Query: 733  LD-DLRTLTLSLFEKATDELRR-------LQNSAMTQELLKRGVPWLFLQQI----LEEH 780
            L   +  L   + EK  D L +       L+ S +T++ L+     L+ Q+     L+  
Sbjct: 1099 LSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRAS---LWAQEAKAAQLQLR 1155

Query: 781  GKEMAARAEQLEGEERDRDQEGVQSVRQRLKDDAPEA---VTEEQAELRR--------WE 829
             +   ++ E L  E++  +Q   Q+    L     +A   V E + EL          W 
Sbjct: 1156 LRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWG 1215

Query: 830  HLIFMKLCSSVFSLSEEELLRMRQEVHGCFAQMDRSLALPKIRARVLLQQFQTAWREAEF 889
                     S+F           + V     ++ + L   +    VL  Q Q        
Sbjct: 1216 LEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTD 1275

Query: 890  VKLDQAVAAPELQQQSKVRKSRSKSKSKGELLKKCIEDKI-HLCEEQASEDLVEKVRGEL 948
             + +++    ELQ   +      + KSK E  +  +E ++  L E  AS      ++  L
Sbjct: 1276 TEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMAS------LQSRL 1329

Query: 949  LRERVQRMEAQEGGFAQSLVALQFQKASRVTETLSAYT---ALLSIQDLLLEELSASEML 1005
             R  +QRMEAQ  G  + L A +    ++V    +A     A  S   +L E+L  +   
Sbjct: 1330 RRAELQRMEAQ--GERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSA 1387

Query: 1006 TKSACTQILESHSRELQELERKLEDQLVQQEAAQQQ-----QALASWQQWVADGPGILNE 1060
             K    ++ ES     Q L+ + E ++ Q +A Q+      Q LA  ++ V    G + E
Sbjct: 1388 LKLKNEEV-ESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQE 1446

Query: 1061 -PGEVDSERQVSTVLHQALSKSQTLLEQHQQCLREEQQNSVVLEDL 1105
               + + ++    +L   L K    ++  Q+ ++E ++   VLE L
Sbjct: 1447 LEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHL 1492



 Score = 57.4 bits (137), Expect = 9e-08
 Identities = 170/810 (20%), Positives = 312/810 (38%), Gaps = 136/810 (16%)

Query: 382  ELEIATLNRADADLEACRTQISKDIIALLLKNLTSSGHLSPQVERKMSAVFKKQFLLLEN 441
            E++ AT +R   +L+A   ++S  ++   L+    +    P    +M      Q LLL  
Sbjct: 193  EMKSAT-DRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLA 251

Query: 442  EIQE------EYDRKMVALTAECDLE---------------TRKKMENQ-YQREMMAMEE 479
            + QE      E  ++++ L ++ DLE               T+ + +N+ Y++ + A+ E
Sbjct: 252  KTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRE 311

Query: 480  AEELLKRAGERSAVECSNLLRTLHG--LEQEHLRKSLALQQEEDFAKAHRQLAVFQRNEL 537
              E+L+          ++L R      L  + + K +     E+     +        EL
Sbjct: 312  TVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLEL 371

Query: 538  HSIFFTQ------------IKSAIFKGELKPEAAKMLLQNYSKIQENVEELMDFFQA--- 582
             S  F+Q            ++S + +   + +A + L Q  +  QE V  L         
Sbjct: 372  DSSIFSQFDYQDADKALTLVRSVLTR---RRQAVQDLRQQLAGCQEAVNLLQQQHDQWEE 428

Query: 583  ---SKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDEDQME 639
               + R  L K  G R+     L      +QG + + + +   L +  E        Q+E
Sbjct: 429  EGKALRQRLQKLTGERD----TLAGQTVDLQGEVDSLSKERELLQKAREEL----RQQLE 480

Query: 640  MLLERA-QTEVFSIKQKLDNDLKQEKKKLHQKLI--TKRRRELLQ--------KHREQRR 688
            +L + A +    +++ +L  D  Q +K+  Q+ +    R RE LQ        K  E   
Sbjct: 481  VLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLS 540

Query: 689  EQASVGEAFRTVEDAGQYLHQKRSLMEEHGATLEELQERLDQAA------LDDLRTLTLS 742
            E  ++ EA  +    G+ L Q+++ +    A  E+    L  +       + DLR   + 
Sbjct: 541  ELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVK 600

Query: 743  LFEKATDELRRLQNSAMTQELLKRGVPWLFLQQILEEHGKEMAARAE---------QLEG 793
            L   A +E   L    + Q+LL+           LEE  + + +R E         Q++ 
Sbjct: 601  L--SALNEALALDKVGLNQQLLQ-----------LEEENQSVCSRMEAAEQARNALQVDL 647

Query: 794  EERDRDQEGVQSVRQRLK---DDAPEAVTEEQAELR---RWEHLIFMKLCSSVFSLSEEE 847
             E ++ +E +      L+     A EA  E QA+LR     +  I  KL  S     +E 
Sbjct: 648  AEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQ--QEA 705

Query: 848  LLRMRQEVHGCFAQMDRSLALPKIRARVLLQQFQTAWREAEFVKLDQAVAAPELQQQSKV 907
                 +++H    + +  LA        L+++        + V+ D+   A +LQ  S  
Sbjct: 706  ATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSA 765

Query: 908  RKSRSKS-------KSKGELLKKCIEDKIHLCEEQASEDLVEKVRGELLRERVQRMEAQE 960
            ++    S        S  E+ K  +E +I     QA E +  +VR   L    +R +A++
Sbjct: 766  KELLESSLFEAQQQNSVIEVTKGQLEVQIQTVT-QAKEVIQGEVRCLKLELDTERSQAEQ 824

Query: 961  GGFA----------QSLVALQFQKASRVTETLSAYTALLSIQDLLLEELSASEMLTKSAC 1010
               A          +   AL+ QKA+   E            + L E+        +   
Sbjct: 825  ERDAAARQLAQAEQEGKTALEQQKAAHEKEV-----------NQLREKWEKERSWHQQEL 873

Query: 1011 TQILESHSRELQELERKLEDQLVQQEAAQQQQALASWQQWVADGPGILNEPGEVDSERQV 1070
             + LES  RE  ELE +L++Q  + EA Q Q+     ++        L +  ++++E++ 
Sbjct: 874  AKALESLEREKMELEMRLKEQQTEMEAIQAQR-----EEERTQAESALCQM-QLETEKER 927

Query: 1071 STVLHQALSKSQTLLEQHQQCLREEQQNSV 1100
             ++L   L   + L +  QQ  R  Q   V
Sbjct: 928  VSLLETLLQTQKELADASQQLERLRQDMKV 957


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 156/718 (21%), Positives = 300/718 (41%), Gaps = 103/718 (14%)

Query: 378  QALEEL--EIATLNRADADLEACRTQISKDIIALLLKNLTSSGHLSPQVERKMSAVFKKQ 435
            QA+EEL  ++    RA A+L+  +  + K+  A L   L   G    +VE K     KK+
Sbjct: 1203 QAVEELTEQLEQFKRAKANLDKNKQTLEKEN-ADLAGELRVLGQAKQEVEHK-----KKK 1256

Query: 436  FLLLENEIQEEYDRKMVALTAECDLETR-KKMENQYQREMMAMEEAE-ELLKRAGERSAV 493
               LE ++QE   +      A  +L  +  K++N+ +     + EAE + +K A  +   
Sbjct: 1257 ---LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA--KDVA 1311

Query: 494  ECSNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVFQRNELHSIFFTQIKSA----- 548
              S+ L+    L QE  R+ L +  +       RQL   +RN L      ++++      
Sbjct: 1312 SLSSQLQDTQELLQEETRQKLNVSTKL------RQLEE-ERNSLQDQLDEEMEAKQNLER 1364

Query: 549  -IFKGELKPEAAKMLLQNYSKIQENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSET 607
             I    ++   +K  LQ+++   E +EE    FQ     +L++++  +      L+ ++ 
Sbjct: 1365 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE-NLTQQYEEKAAAYDKLEKTKN 1423

Query: 608  RVQGLLSTAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLKQ-EKKK 666
            R+Q  L      L +   + +    L++ Q +     A+ +  S K   + D  + E ++
Sbjct: 1424 RLQQELDDLVVDLDN---QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1480

Query: 667  LHQKLITKRR--RELLQKHREQRRE----QASVGEAFRTVEDAGQYLHQ----KRSL--- 713
               K ++  R   E L+   E  R     +A + +   + +D G+ +H+    KR+L   
Sbjct: 1481 KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1540

Query: 714  MEEHGATLEELQERLDQAALDDLRTLTLSLFEKATDELRRLQNSAMTQELLKRGVPWLFL 773
            MEE    LEEL++ L QA  D    L +++        R LQ      E  +R      L
Sbjct: 1541 MEEMKTQLEELEDEL-QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ-----L 1594

Query: 774  QQILEEHGKEM----------AARAEQLEGEERDRDQEGVQSVRQRLKDDAPEAVTEEQA 823
            Q+ L E+  E+          AA  ++LEG+ +D + +   +++ R  ++A + + + QA
Sbjct: 1595 QRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGR--EEAIKQLRKLQA 1652

Query: 824  ELRRWEHLIFMKLCSSVFSLSEEELLRMRQEVHGCFAQMDRSLALPKIRARVLLQQFQTA 883
            +++ ++  +             E+    R E+     + ++     +     L +    A
Sbjct: 1653 QMKDFQREL-------------EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1699

Query: 884  WREAEFVKLDQAVAAPELQQQSKVRKSRSKSKSKGELLKKCIEDKIHLCEEQASEDLV-- 941
             R  +   L++   A EL      R +    K + E     +E+++   EEQ + + +  
Sbjct: 1700 ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE--EEQGNMEAMSD 1757

Query: 942  ---------EKVRGELLRERV---------QRMEAQEGGFAQSLVALQFQKASRVTETLS 983
                     E++  EL  ER          Q++E Q       L  ++    S+   T++
Sbjct: 1758 RVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA 1817

Query: 984  AYTALLSIQDLLLEELSASEMLTKSACTQILESHSRELQELERKLEDQLVQQEAAQQQ 1041
            A  A ++     LEE    E   K A T+ L+   ++L+E+  ++ED+    E  ++Q
Sbjct: 1818 ALEAKIA----QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQ 1871



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 111/461 (24%), Positives = 186/461 (40%), Gaps = 103/461 (22%)

Query: 670  KLITKRRRELLQKHREQRREQASVGEAFRTVEDAGQYLHQKRSLMEEHGATLEE---LQE 726
            +L TK +  LLQ  R++   QA   E  +T E   +  ++ + L ++H    EE   LQE
Sbjct: 836  RLFTKVK-PLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE 894

Query: 727  RLDQAALDDLRTLTLSLFEKATDELRRLQNSAMTQELLKRGVPWLFLQQILEEHGKEMAA 786
            +L              L+ +A  E  R++ +A  QE              LEE   EM A
Sbjct: 895  QLQAET---------ELYAEA--EEMRVRLAAKKQE--------------LEEILHEMEA 929

Query: 787  RAEQLEGEERDRDQEGVQSVRQRLKDDAPEAVTEEQAELRRWEHLIFMKLCSSVFSLSEE 846
            R E    EE DR Q+ +Q+ R+++     +   EEQ                    L EE
Sbjct: 930  RLE----EEEDRGQQ-LQAERKKMAQQMLD--LEEQ--------------------LEEE 962

Query: 847  ELLRMRQEVHGCFAQMDRSLALPKIRARVLLQQFQTAWREAEFVKLDQAVA--APELQQQ 904
            E  R + ++    A+      + K+   +L+   Q      E   L++ ++     L ++
Sbjct: 963  EAARQKLQLEKVTAE----AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1018

Query: 905  SKVRKSRSKSKSKGELLKKCIEDKIHLCEEQASEDLVEKVRGEL------LRERVQRMEA 958
             +  K+ +K K+K E +   +E  + L +E+ S   +EK++ +L        E++  ++A
Sbjct: 1019 EEKAKNLTKLKNKHESMISELE--VRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1076

Query: 959  QEGGFAQSLV----ALQFQKASRVTETLSAYTALLSIQDLL-----LEELSASEMLTKSA 1009
            Q       L      LQ   A    E      AL  I++L      L+E   SE   ++ 
Sbjct: 1077 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK 1136

Query: 1010 CTQILESHSRELQELERKLEDQLVQQEAAQQQQALASWQQWVADGPGILNEPGEVDSERQ 1069
              +       EL+ L+ +LED L     A QQ+  A  +Q V                  
Sbjct: 1137 AEKQKRDLGEELEALKTELEDTL--DSTATQQELRAKREQEV------------------ 1176

Query: 1070 VSTVLHQALSKSQTLLEQHQQCLREEQQNSVVLEDLLENME 1110
              TVL +AL +     E   Q +R  Q+++  +E+L E +E
Sbjct: 1177 --TVLKKALDEETRSHEAQVQEMR--QKHAQAVEELTEQLE 1213



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 135/727 (18%), Positives = 291/727 (40%), Gaps = 74/727 (10%)

Query: 360  LNDQMIDILSSEDPGSMLQALEELEIATLNRADADLEACRTQISKDIIALLLKNLTSSGH 419
            L++    +   ED G  LQA  +     +   +  LE       K    L L+ +T+   
Sbjct: 924  LHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK----LQLEKVTAEAK 979

Query: 420  LSPQVERKMSAVFKKQFLLLENEIQEEYDRKMVALTAECDLETRKKMENQYQREMMAMEE 479
            +    +  +    +   L  E ++ EE    +    AE + + +   + + + E M + E
Sbjct: 980  IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESM-ISE 1038

Query: 480  AEELLKRAGERSAVECSNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVFQRNELHS 539
             E  LK+  E+S  E   L R L G   +   +   LQ +   A+   QLA  ++ E   
Sbjct: 1039 LEVRLKKE-EKSRQELEKLKRKLEGDASDFHEQIADLQAQ--IAELKMQLA--KKEEELQ 1093

Query: 540  IFFTQIKSAIFKGELKPEAAKMLLQNYSKIQENVEELMDFFQASKRYHLSKRFGHREYLV 599
                ++   I +     +  + L  + S +QE+++        S+R   +K    +  L 
Sbjct: 1094 AALARLDDEIAQKNNALKKIRELEGHISDLQEDLD--------SERAARNKAEKQKRDLG 1145

Query: 600  QNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDND 659
            + L++ +T ++  L + A Q   L  K E+   + +  ++      + +V  ++QK    
Sbjct: 1146 EELEALKTELEDTLDSTATQ-QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1204

Query: 660  LKQEKKKLHQKLITKRRRELLQKHREQ-RREQASVGEAFRTVEDAGQYLHQKRSLMEEHG 718
            +++  ++L Q    KR +  L K+++   +E A +    R +  A Q +  K+  +E   
Sbjct: 1205 VEELTEQLEQ---FKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE--- 1258

Query: 719  ATLEELQERLD-----QAALDDLRTLTLSLFEKATDELRRLQNSA--MTQELLKRGVPWL 771
            A ++ELQ +       +A L+D      +  E  T  L   +  A  + +++        
Sbjct: 1259 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1318

Query: 772  FLQQILEEHGKE---MAARAEQLEGEER------DRDQEGVQSV--------------RQ 808
              Q++L+E  ++   ++ +  QLE E        D + E  Q++              ++
Sbjct: 1319 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1378

Query: 809  RLKDDAPEAVTEEQAELRRWEHLIFM----KLCSSVFSLSEEELLRMRQEVHGCFAQMDR 864
            +L+D A      E+ + R  + +  +    +  ++ +   E+   R++QE+      +D 
Sbjct: 1379 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1438

Query: 865  SLALPKIRARVLLQQFQTAWREAEFVKLDQA-VAAPELQQQSKVRKSRSKSKSKGELLKK 923
                     R L+   +   R+ + +  ++  +++    ++ +      + ++K   L +
Sbjct: 1439 Q--------RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1490

Query: 924  CIEDKIHLCEEQASEDLVEKVRGELLRERVQRMEAQEGGFAQSLVALQFQKASRVTETLS 983
             +E+ +   EE    + + K   E L      +        +S  AL+ Q     T+   
Sbjct: 1491 ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1550

Query: 984  AYTALLSIQDLLLEELSASEMLTKSACTQILESHSRELQELERKLEDQLVQQEAA----Q 1039
                L + +D  L  L  +    K    + L++   + +E  R+L+ QL + E      +
Sbjct: 1551 LEDELQATEDAKLR-LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1609

Query: 1040 QQQALAS 1046
            +Q+ALA+
Sbjct: 1610 KQRALAA 1616



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 92/398 (23%), Positives = 168/398 (42%), Gaps = 48/398 (12%)

Query: 359  SLNDQMIDILSS-EDPGSMLQALEELEIATLNRADADLEACRTQISKDIIALLLKNLTSS 417
            +L  QM ++ +  E+    LQA E+ ++    R + +++A + Q  +D+ A   +N    
Sbjct: 1536 ALETQMEEMKTQLEELEDELQATEDAKL----RLEVNMQALKGQFERDLQARDEQNEEKR 1591

Query: 418  GHLSPQV---ERKMSAVFKKQFLLLENEIQEEYDRKMVALTAECDLETRKKMENQYQREM 474
              L  Q+   E ++    K++ L    + + E D K + L A+  ++ R++   Q ++  
Sbjct: 1592 RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQ 1651

Query: 475  MAMEEAEELLKRA-GERSAVECSNLLRTLHGLEQEHLRKSLA---LQQEEDFAKAHR--Q 528
              M++ +  L+ A   R  +  +         E E   KSL    +Q +ED A A R  +
Sbjct: 1652 AQMKDFQRELEDARASRDEIFAT-------AKENEKKAKSLEADLMQLQEDLAAAERARK 1704

Query: 529  LAVFQRNELHSIFFTQIKSAIFKGELKPEAAKMLLQNYSKIQENVEELMDFFQASKRYHL 588
             A  ++ EL      ++ S++       +  + L    ++++E +EE     +A     +
Sbjct: 1705 QADLEKEELAE----ELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD-RV 1759

Query: 589  SKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQK-----HERAGYLD--------- 634
             K     E L   L +  +  Q   S A  QL    ++     HE  G +          
Sbjct: 1760 RKATQQAEQLSNELATERSTAQKNES-ARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1818

Query: 635  -EDQMEMLLERAQTEVFSIKQKLDNDLKQEKKKLHQKLITKRRRELLQKHREQRREQASV 693
             E ++  L E+ + E    KQ     LKQ+ KKL + L+   + E  +K  EQ +EQA  
Sbjct: 1819 LEAKIAQLEEQVEQEARE-KQAATKSLKQKDKKLKEILL---QVEDERKMAEQYKEQAEK 1874

Query: 694  GEAFRTVEDAGQYLHQKRSLMEEHGATLEELQERLDQA 731
            G A   V+   + L +     +   A   +LQ  LD+A
Sbjct: 1875 GNA--RVKQLKRQLEEAEEESQRINANRRKLQRELDEA 1910



 Score = 40.8 bits (94), Expect = 0.009
 Identities = 107/532 (20%), Positives = 209/532 (39%), Gaps = 118/532 (22%)

Query: 663  EKKKLHQKLITKRRRELLQKHREQRREQASVGEAFRT----------------------- 699
            +K K  Q+      +EL QKH +   E+  + E  +                        
Sbjct: 862  QKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELE 921

Query: 700  ------------VEDAGQYLHQKRSLMEEHGATLEELQERLDQAALDDL---RTLTLSLF 744
                         ED GQ L  +R  M +    LEE  E  ++AA   L   +    +  
Sbjct: 922  EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE-EEAARQKLQLEKVTAEAKI 980

Query: 745  EKATDELRRL--QNSAMTQE--LLKRGVPWLF------------LQQILEEHGKEMAARA 788
            +K  DE+  +  QN+ +++E  LL+  +  L             L ++  +H   ++   
Sbjct: 981  KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE 1040

Query: 789  EQLEGEERDRDQEGVQSVRQRLKDDAP---EAVTEEQAELRRWEHLIFMK---LCSSVFS 842
             +L+ EE+ R +  ++ ++++L+ DA    E + + QA++   +  +  K   L +++  
Sbjct: 1041 VRLKKEEKSRQE--LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALAR 1098

Query: 843  LSEE-----ELLRMRQEVHGCFAQMDRSLALPKIRARVLLQQFQTAWREAEFVKLDQAVA 897
            L +E       L+  +E+ G  + +   L   +       +Q +    E E +K +    
Sbjct: 1099 LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE---L 1155

Query: 898  APELQQQSKVRKSRSKSKSKGELLKKCIEDKIHLCEEQASEDLVEKVRGELLRERVQRME 957
               L   +  ++ R+K + +  +LKK ++++    E Q  E  + +   + + E  +++E
Sbjct: 1156 EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE--MRQKHAQAVEELTEQLE 1213

Query: 958  AQEGGFAQSLVALQFQKA----SRVTETLSAYTALLSIQDLLLEELSASEMLTKSACTQI 1013
                         QF++A     +  +TL    A L           A E+       Q 
Sbjct: 1214 -------------QFKRAKANLDKNKQTLEKENADL-----------AGELRVLGQAKQE 1249

Query: 1014 LESHSREL----QELERKLEDQLVQQEAAQQQQALASWQQWVADGPGILNEP--GEVDSE 1067
            +E   ++L    QEL+ K  D   ++  A+    +   Q  V    G+LNE     +   
Sbjct: 1250 VEHKKKKLEAQVQELQSKCSDG--ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1307

Query: 1068 RQVSTVLHQALSKSQTLLEQHQQCLR--------EEQQNSVVLEDLLENMEA 1111
            + V+++  Q     + L E+ +Q L         EE++NS + + L E MEA
Sbjct: 1308 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS-LQDQLDEEMEA 1358


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 156/718 (21%), Positives = 300/718 (41%), Gaps = 103/718 (14%)

Query: 378  QALEEL--EIATLNRADADLEACRTQISKDIIALLLKNLTSSGHLSPQVERKMSAVFKKQ 435
            QA+EEL  ++    RA A+L+  +  + K+  A L   L   G    +VE K     KK+
Sbjct: 1210 QAVEELTEQLEQFKRAKANLDKNKQTLEKEN-ADLAGELRVLGQAKQEVEHK-----KKK 1263

Query: 436  FLLLENEIQEEYDRKMVALTAECDLETR-KKMENQYQREMMAMEEAE-ELLKRAGERSAV 493
               LE ++QE   +      A  +L  +  K++N+ +     + EAE + +K A  +   
Sbjct: 1264 ---LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA--KDVA 1318

Query: 494  ECSNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVFQRNELHSIFFTQIKSA----- 548
              S+ L+    L QE  R+ L +  +       RQL   +RN L      ++++      
Sbjct: 1319 SLSSQLQDTQELLQEETRQKLNVSTKL------RQLEE-ERNSLQDQLDEEMEAKQNLER 1371

Query: 549  -IFKGELKPEAAKMLLQNYSKIQENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSET 607
             I    ++   +K  LQ+++   E +EE    FQ     +L++++  +      L+ ++ 
Sbjct: 1372 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE-NLTQQYEEKAAAYDKLEKTKN 1430

Query: 608  RVQGLLSTAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLKQ-EKKK 666
            R+Q  L      L +   + +    L++ Q +     A+ +  S K   + D  + E ++
Sbjct: 1431 RLQQELDDLVVDLDN---QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1487

Query: 667  LHQKLITKRR--RELLQKHREQRRE----QASVGEAFRTVEDAGQYLHQ----KRSL--- 713
               K ++  R   E L+   E  R     +A + +   + +D G+ +H+    KR+L   
Sbjct: 1488 KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1547

Query: 714  MEEHGATLEELQERLDQAALDDLRTLTLSLFEKATDELRRLQNSAMTQELLKRGVPWLFL 773
            MEE    LEEL++ L QA  D    L +++        R LQ      E  +R      L
Sbjct: 1548 MEEMKTQLEELEDEL-QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ-----L 1601

Query: 774  QQILEEHGKEM----------AARAEQLEGEERDRDQEGVQSVRQRLKDDAPEAVTEEQA 823
            Q+ L E+  E+          AA  ++LEG+ +D + +   +++ R  ++A + + + QA
Sbjct: 1602 QRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGR--EEAIKQLRKLQA 1659

Query: 824  ELRRWEHLIFMKLCSSVFSLSEEELLRMRQEVHGCFAQMDRSLALPKIRARVLLQQFQTA 883
            +++ ++  +             E+    R E+     + ++     +     L +    A
Sbjct: 1660 QMKDFQREL-------------EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1706

Query: 884  WREAEFVKLDQAVAAPELQQQSKVRKSRSKSKSKGELLKKCIEDKIHLCEEQASEDLV-- 941
             R  +   L++   A EL      R +    K + E     +E+++   EEQ + + +  
Sbjct: 1707 ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE--EEQGNMEAMSD 1764

Query: 942  ---------EKVRGELLRERV---------QRMEAQEGGFAQSLVALQFQKASRVTETLS 983
                     E++  EL  ER          Q++E Q       L  ++    S+   T++
Sbjct: 1765 RVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA 1824

Query: 984  AYTALLSIQDLLLEELSASEMLTKSACTQILESHSRELQELERKLEDQLVQQEAAQQQ 1041
            A  A ++     LEE    E   K A T+ L+   ++L+E+  ++ED+    E  ++Q
Sbjct: 1825 ALEAKIA----QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQ 1878



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 111/461 (24%), Positives = 186/461 (40%), Gaps = 103/461 (22%)

Query: 670  KLITKRRRELLQKHREQRREQASVGEAFRTVEDAGQYLHQKRSLMEEHGATLEE---LQE 726
            +L TK +  LLQ  R++   QA   E  +T E   +  ++ + L ++H    EE   LQE
Sbjct: 843  RLFTKVK-PLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE 901

Query: 727  RLDQAALDDLRTLTLSLFEKATDELRRLQNSAMTQELLKRGVPWLFLQQILEEHGKEMAA 786
            +L              L+ +A  E  R++ +A  QE              LEE   EM A
Sbjct: 902  QLQAET---------ELYAEA--EEMRVRLAAKKQE--------------LEEILHEMEA 936

Query: 787  RAEQLEGEERDRDQEGVQSVRQRLKDDAPEAVTEEQAELRRWEHLIFMKLCSSVFSLSEE 846
            R E    EE DR Q+ +Q+ R+++     +   EEQ                    L EE
Sbjct: 937  RLE----EEEDRGQQ-LQAERKKMAQQMLD--LEEQ--------------------LEEE 969

Query: 847  ELLRMRQEVHGCFAQMDRSLALPKIRARVLLQQFQTAWREAEFVKLDQAVA--APELQQQ 904
            E  R + ++    A+      + K+   +L+   Q      E   L++ ++     L ++
Sbjct: 970  EAARQKLQLEKVTAE----AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1025

Query: 905  SKVRKSRSKSKSKGELLKKCIEDKIHLCEEQASEDLVEKVRGEL------LRERVQRMEA 958
             +  K+ +K K+K E +   +E  + L +E+ S   +EK++ +L        E++  ++A
Sbjct: 1026 EEKAKNLTKLKNKHESMISELE--VRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1083

Query: 959  QEGGFAQSLV----ALQFQKASRVTETLSAYTALLSIQDLL-----LEELSASEMLTKSA 1009
            Q       L      LQ   A    E      AL  I++L      L+E   SE   ++ 
Sbjct: 1084 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK 1143

Query: 1010 CTQILESHSRELQELERKLEDQLVQQEAAQQQQALASWQQWVADGPGILNEPGEVDSERQ 1069
              +       EL+ L+ +LED L     A QQ+  A  +Q V                  
Sbjct: 1144 AEKQKRDLGEELEALKTELEDTL--DSTATQQELRAKREQEV------------------ 1183

Query: 1070 VSTVLHQALSKSQTLLEQHQQCLREEQQNSVVLEDLLENME 1110
              TVL +AL +     E   Q +R  Q+++  +E+L E +E
Sbjct: 1184 --TVLKKALDEETRSHEAQVQEMR--QKHAQAVEELTEQLE 1220



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 135/727 (18%), Positives = 291/727 (40%), Gaps = 74/727 (10%)

Query: 360  LNDQMIDILSSEDPGSMLQALEELEIATLNRADADLEACRTQISKDIIALLLKNLTSSGH 419
            L++    +   ED G  LQA  +     +   +  LE       K    L L+ +T+   
Sbjct: 931  LHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK----LQLEKVTAEAK 986

Query: 420  LSPQVERKMSAVFKKQFLLLENEIQEEYDRKMVALTAECDLETRKKMENQYQREMMAMEE 479
            +    +  +    +   L  E ++ EE    +    AE + + +   + + + E M + E
Sbjct: 987  IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESM-ISE 1045

Query: 480  AEELLKRAGERSAVECSNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVFQRNELHS 539
             E  LK+  E+S  E   L R L G   +   +   LQ +   A+   QLA  ++ E   
Sbjct: 1046 LEVRLKKE-EKSRQELEKLKRKLEGDASDFHEQIADLQAQ--IAELKMQLA--KKEEELQ 1100

Query: 540  IFFTQIKSAIFKGELKPEAAKMLLQNYSKIQENVEELMDFFQASKRYHLSKRFGHREYLV 599
                ++   I +     +  + L  + S +QE+++        S+R   +K    +  L 
Sbjct: 1101 AALARLDDEIAQKNNALKKIRELEGHISDLQEDLD--------SERAARNKAEKQKRDLG 1152

Query: 600  QNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDND 659
            + L++ +T ++  L + A Q   L  K E+   + +  ++      + +V  ++QK    
Sbjct: 1153 EELEALKTELEDTLDSTATQ-QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1211

Query: 660  LKQEKKKLHQKLITKRRRELLQKHREQ-RREQASVGEAFRTVEDAGQYLHQKRSLMEEHG 718
            +++  ++L Q    KR +  L K+++   +E A +    R +  A Q +  K+  +E   
Sbjct: 1212 VEELTEQLEQ---FKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE--- 1265

Query: 719  ATLEELQERLD-----QAALDDLRTLTLSLFEKATDELRRLQNSA--MTQELLKRGVPWL 771
            A ++ELQ +       +A L+D      +  E  T  L   +  A  + +++        
Sbjct: 1266 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1325

Query: 772  FLQQILEEHGKE---MAARAEQLEGEER------DRDQEGVQSV--------------RQ 808
              Q++L+E  ++   ++ +  QLE E        D + E  Q++              ++
Sbjct: 1326 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1385

Query: 809  RLKDDAPEAVTEEQAELRRWEHLIFM----KLCSSVFSLSEEELLRMRQEVHGCFAQMDR 864
            +L+D A      E+ + R  + +  +    +  ++ +   E+   R++QE+      +D 
Sbjct: 1386 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1445

Query: 865  SLALPKIRARVLLQQFQTAWREAEFVKLDQA-VAAPELQQQSKVRKSRSKSKSKGELLKK 923
                     R L+   +   R+ + +  ++  +++    ++ +      + ++K   L +
Sbjct: 1446 Q--------RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1497

Query: 924  CIEDKIHLCEEQASEDLVEKVRGELLRERVQRMEAQEGGFAQSLVALQFQKASRVTETLS 983
             +E+ +   EE    + + K   E L      +        +S  AL+ Q     T+   
Sbjct: 1498 ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1557

Query: 984  AYTALLSIQDLLLEELSASEMLTKSACTQILESHSRELQELERKLEDQLVQQEAA----Q 1039
                L + +D  L  L  +    K    + L++   + +E  R+L+ QL + E      +
Sbjct: 1558 LEDELQATEDAKLR-LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1616

Query: 1040 QQQALAS 1046
            +Q+ALA+
Sbjct: 1617 KQRALAA 1623



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 92/398 (23%), Positives = 168/398 (42%), Gaps = 48/398 (12%)

Query: 359  SLNDQMIDILSS-EDPGSMLQALEELEIATLNRADADLEACRTQISKDIIALLLKNLTSS 417
            +L  QM ++ +  E+    LQA E+ ++    R + +++A + Q  +D+ A   +N    
Sbjct: 1543 ALETQMEEMKTQLEELEDELQATEDAKL----RLEVNMQALKGQFERDLQARDEQNEEKR 1598

Query: 418  GHLSPQV---ERKMSAVFKKQFLLLENEIQEEYDRKMVALTAECDLETRKKMENQYQREM 474
              L  Q+   E ++    K++ L    + + E D K + L A+  ++ R++   Q ++  
Sbjct: 1599 RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQ 1658

Query: 475  MAMEEAEELLKRA-GERSAVECSNLLRTLHGLEQEHLRKSLA---LQQEEDFAKAHR--Q 528
              M++ +  L+ A   R  +  +         E E   KSL    +Q +ED A A R  +
Sbjct: 1659 AQMKDFQRELEDARASRDEIFAT-------AKENEKKAKSLEADLMQLQEDLAAAERARK 1711

Query: 529  LAVFQRNELHSIFFTQIKSAIFKGELKPEAAKMLLQNYSKIQENVEELMDFFQASKRYHL 588
             A  ++ EL      ++ S++       +  + L    ++++E +EE     +A     +
Sbjct: 1712 QADLEKEELAE----ELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD-RV 1766

Query: 589  SKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQK-----HERAGYLD--------- 634
             K     E L   L +  +  Q   S A  QL    ++     HE  G +          
Sbjct: 1767 RKATQQAEQLSNELATERSTAQKNES-ARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1825

Query: 635  -EDQMEMLLERAQTEVFSIKQKLDNDLKQEKKKLHQKLITKRRRELLQKHREQRREQASV 693
             E ++  L E+ + E    KQ     LKQ+ KKL + L+   + E  +K  EQ +EQA  
Sbjct: 1826 LEAKIAQLEEQVEQEARE-KQAATKSLKQKDKKLKEILL---QVEDERKMAEQYKEQAEK 1881

Query: 694  GEAFRTVEDAGQYLHQKRSLMEEHGATLEELQERLDQA 731
            G A   V+   + L +     +   A   +LQ  LD+A
Sbjct: 1882 GNA--RVKQLKRQLEEAEEESQRINANRRKLQRELDEA 1917



 Score = 40.8 bits (94), Expect = 0.009
 Identities = 107/532 (20%), Positives = 209/532 (39%), Gaps = 118/532 (22%)

Query: 663  EKKKLHQKLITKRRRELLQKHREQRREQASVGEAFRT----------------------- 699
            +K K  Q+      +EL QKH +   E+  + E  +                        
Sbjct: 869  QKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELE 928

Query: 700  ------------VEDAGQYLHQKRSLMEEHGATLEELQERLDQAALDDL---RTLTLSLF 744
                         ED GQ L  +R  M +    LEE  E  ++AA   L   +    +  
Sbjct: 929  EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE-EEAARQKLQLEKVTAEAKI 987

Query: 745  EKATDELRRL--QNSAMTQE--LLKRGVPWLF------------LQQILEEHGKEMAARA 788
            +K  DE+  +  QN+ +++E  LL+  +  L             L ++  +H   ++   
Sbjct: 988  KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE 1047

Query: 789  EQLEGEERDRDQEGVQSVRQRLKDDAP---EAVTEEQAELRRWEHLIFMK---LCSSVFS 842
             +L+ EE+ R +  ++ ++++L+ DA    E + + QA++   +  +  K   L +++  
Sbjct: 1048 VRLKKEEKSRQE--LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALAR 1105

Query: 843  LSEE-----ELLRMRQEVHGCFAQMDRSLALPKIRARVLLQQFQTAWREAEFVKLDQAVA 897
            L +E       L+  +E+ G  + +   L   +       +Q +    E E +K +    
Sbjct: 1106 LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE---L 1162

Query: 898  APELQQQSKVRKSRSKSKSKGELLKKCIEDKIHLCEEQASEDLVEKVRGELLRERVQRME 957
               L   +  ++ R+K + +  +LKK ++++    E Q  E  + +   + + E  +++E
Sbjct: 1163 EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE--MRQKHAQAVEELTEQLE 1220

Query: 958  AQEGGFAQSLVALQFQKA----SRVTETLSAYTALLSIQDLLLEELSASEMLTKSACTQI 1013
                         QF++A     +  +TL    A L           A E+       Q 
Sbjct: 1221 -------------QFKRAKANLDKNKQTLEKENADL-----------AGELRVLGQAKQE 1256

Query: 1014 LESHSREL----QELERKLEDQLVQQEAAQQQQALASWQQWVADGPGILNEP--GEVDSE 1067
            +E   ++L    QEL+ K  D   ++  A+    +   Q  V    G+LNE     +   
Sbjct: 1257 VEHKKKKLEAQVQELQSKCSDG--ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1314

Query: 1068 RQVSTVLHQALSKSQTLLEQHQQCLR--------EEQQNSVVLEDLLENMEA 1111
            + V+++  Q     + L E+ +Q L         EE++NS + + L E MEA
Sbjct: 1315 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS-LQDQLDEEMEA 1365


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 156/718 (21%), Positives = 300/718 (41%), Gaps = 103/718 (14%)

Query: 378  QALEEL--EIATLNRADADLEACRTQISKDIIALLLKNLTSSGHLSPQVERKMSAVFKKQ 435
            QA+EEL  ++    RA A+L+  +  + K+  A L   L   G    +VE K     KK+
Sbjct: 1210 QAVEELTEQLEQFKRAKANLDKNKQTLEKEN-ADLAGELRVLGQAKQEVEHK-----KKK 1263

Query: 436  FLLLENEIQEEYDRKMVALTAECDLETR-KKMENQYQREMMAMEEAE-ELLKRAGERSAV 493
               LE ++QE   +      A  +L  +  K++N+ +     + EAE + +K A  +   
Sbjct: 1264 ---LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA--KDVA 1318

Query: 494  ECSNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVFQRNELHSIFFTQIKSA----- 548
              S+ L+    L QE  R+ L +  +       RQL   +RN L      ++++      
Sbjct: 1319 SLSSQLQDTQELLQEETRQKLNVSTKL------RQLEE-ERNSLQDQLDEEMEAKQNLER 1371

Query: 549  -IFKGELKPEAAKMLLQNYSKIQENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSET 607
             I    ++   +K  LQ+++   E +EE    FQ     +L++++  +      L+ ++ 
Sbjct: 1372 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE-NLTQQYEEKAAAYDKLEKTKN 1430

Query: 608  RVQGLLSTAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLKQ-EKKK 666
            R+Q  L      L +   + +    L++ Q +     A+ +  S K   + D  + E ++
Sbjct: 1431 RLQQELDDLVVDLDN---QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1487

Query: 667  LHQKLITKRR--RELLQKHREQRRE----QASVGEAFRTVEDAGQYLHQ----KRSL--- 713
               K ++  R   E L+   E  R     +A + +   + +D G+ +H+    KR+L   
Sbjct: 1488 KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1547

Query: 714  MEEHGATLEELQERLDQAALDDLRTLTLSLFEKATDELRRLQNSAMTQELLKRGVPWLFL 773
            MEE    LEEL++ L QA  D    L +++        R LQ      E  +R      L
Sbjct: 1548 MEEMKTQLEELEDEL-QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ-----L 1601

Query: 774  QQILEEHGKEM----------AARAEQLEGEERDRDQEGVQSVRQRLKDDAPEAVTEEQA 823
            Q+ L E+  E+          AA  ++LEG+ +D + +   +++ R  ++A + + + QA
Sbjct: 1602 QRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGR--EEAIKQLRKLQA 1659

Query: 824  ELRRWEHLIFMKLCSSVFSLSEEELLRMRQEVHGCFAQMDRSLALPKIRARVLLQQFQTA 883
            +++ ++  +             E+    R E+     + ++     +     L +    A
Sbjct: 1660 QMKDFQREL-------------EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1706

Query: 884  WREAEFVKLDQAVAAPELQQQSKVRKSRSKSKSKGELLKKCIEDKIHLCEEQASEDLV-- 941
             R  +   L++   A EL      R +    K + E     +E+++   EEQ + + +  
Sbjct: 1707 ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE--EEQGNMEAMSD 1764

Query: 942  ---------EKVRGELLRERV---------QRMEAQEGGFAQSLVALQFQKASRVTETLS 983
                     E++  EL  ER          Q++E Q       L  ++    S+   T++
Sbjct: 1765 RVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA 1824

Query: 984  AYTALLSIQDLLLEELSASEMLTKSACTQILESHSRELQELERKLEDQLVQQEAAQQQ 1041
            A  A ++     LEE    E   K A T+ L+   ++L+E+  ++ED+    E  ++Q
Sbjct: 1825 ALEAKIA----QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQ 1878



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 111/461 (24%), Positives = 186/461 (40%), Gaps = 103/461 (22%)

Query: 670  KLITKRRRELLQKHREQRREQASVGEAFRTVEDAGQYLHQKRSLMEEHGATLEE---LQE 726
            +L TK +  LLQ  R++   QA   E  +T E   +  ++ + L ++H    EE   LQE
Sbjct: 843  RLFTKVK-PLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE 901

Query: 727  RLDQAALDDLRTLTLSLFEKATDELRRLQNSAMTQELLKRGVPWLFLQQILEEHGKEMAA 786
            +L              L+ +A  E  R++ +A  QE              LEE   EM A
Sbjct: 902  QLQAET---------ELYAEA--EEMRVRLAAKKQE--------------LEEILHEMEA 936

Query: 787  RAEQLEGEERDRDQEGVQSVRQRLKDDAPEAVTEEQAELRRWEHLIFMKLCSSVFSLSEE 846
            R E    EE DR Q+ +Q+ R+++     +   EEQ                    L EE
Sbjct: 937  RLE----EEEDRGQQ-LQAERKKMAQQMLD--LEEQ--------------------LEEE 969

Query: 847  ELLRMRQEVHGCFAQMDRSLALPKIRARVLLQQFQTAWREAEFVKLDQAVA--APELQQQ 904
            E  R + ++    A+      + K+   +L+   Q      E   L++ ++     L ++
Sbjct: 970  EAARQKLQLEKVTAE----AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1025

Query: 905  SKVRKSRSKSKSKGELLKKCIEDKIHLCEEQASEDLVEKVRGEL------LRERVQRMEA 958
             +  K+ +K K+K E +   +E  + L +E+ S   +EK++ +L        E++  ++A
Sbjct: 1026 EEKAKNLTKLKNKHESMISELE--VRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1083

Query: 959  QEGGFAQSLV----ALQFQKASRVTETLSAYTALLSIQDLL-----LEELSASEMLTKSA 1009
            Q       L      LQ   A    E      AL  I++L      L+E   SE   ++ 
Sbjct: 1084 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK 1143

Query: 1010 CTQILESHSRELQELERKLEDQLVQQEAAQQQQALASWQQWVADGPGILNEPGEVDSERQ 1069
              +       EL+ L+ +LED L     A QQ+  A  +Q V                  
Sbjct: 1144 AEKQKRDLGEELEALKTELEDTL--DSTATQQELRAKREQEV------------------ 1183

Query: 1070 VSTVLHQALSKSQTLLEQHQQCLREEQQNSVVLEDLLENME 1110
              TVL +AL +     E   Q +R  Q+++  +E+L E +E
Sbjct: 1184 --TVLKKALDEETRSHEAQVQEMR--QKHAQAVEELTEQLE 1220



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 135/727 (18%), Positives = 291/727 (40%), Gaps = 74/727 (10%)

Query: 360  LNDQMIDILSSEDPGSMLQALEELEIATLNRADADLEACRTQISKDIIALLLKNLTSSGH 419
            L++    +   ED G  LQA  +     +   +  LE       K    L L+ +T+   
Sbjct: 931  LHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK----LQLEKVTAEAK 986

Query: 420  LSPQVERKMSAVFKKQFLLLENEIQEEYDRKMVALTAECDLETRKKMENQYQREMMAMEE 479
            +    +  +    +   L  E ++ EE    +    AE + + +   + + + E M + E
Sbjct: 987  IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESM-ISE 1045

Query: 480  AEELLKRAGERSAVECSNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVFQRNELHS 539
             E  LK+  E+S  E   L R L G   +   +   LQ +   A+   QLA  ++ E   
Sbjct: 1046 LEVRLKKE-EKSRQELEKLKRKLEGDASDFHEQIADLQAQ--IAELKMQLA--KKEEELQ 1100

Query: 540  IFFTQIKSAIFKGELKPEAAKMLLQNYSKIQENVEELMDFFQASKRYHLSKRFGHREYLV 599
                ++   I +     +  + L  + S +QE+++        S+R   +K    +  L 
Sbjct: 1101 AALARLDDEIAQKNNALKKIRELEGHISDLQEDLD--------SERAARNKAEKQKRDLG 1152

Query: 600  QNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDND 659
            + L++ +T ++  L + A Q   L  K E+   + +  ++      + +V  ++QK    
Sbjct: 1153 EELEALKTELEDTLDSTATQ-QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1211

Query: 660  LKQEKKKLHQKLITKRRRELLQKHREQ-RREQASVGEAFRTVEDAGQYLHQKRSLMEEHG 718
            +++  ++L Q    KR +  L K+++   +E A +    R +  A Q +  K+  +E   
Sbjct: 1212 VEELTEQLEQ---FKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE--- 1265

Query: 719  ATLEELQERLD-----QAALDDLRTLTLSLFEKATDELRRLQNSA--MTQELLKRGVPWL 771
            A ++ELQ +       +A L+D      +  E  T  L   +  A  + +++        
Sbjct: 1266 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1325

Query: 772  FLQQILEEHGKE---MAARAEQLEGEER------DRDQEGVQSV--------------RQ 808
              Q++L+E  ++   ++ +  QLE E        D + E  Q++              ++
Sbjct: 1326 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1385

Query: 809  RLKDDAPEAVTEEQAELRRWEHLIFM----KLCSSVFSLSEEELLRMRQEVHGCFAQMDR 864
            +L+D A      E+ + R  + +  +    +  ++ +   E+   R++QE+      +D 
Sbjct: 1386 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1445

Query: 865  SLALPKIRARVLLQQFQTAWREAEFVKLDQA-VAAPELQQQSKVRKSRSKSKSKGELLKK 923
                     R L+   +   R+ + +  ++  +++    ++ +      + ++K   L +
Sbjct: 1446 Q--------RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1497

Query: 924  CIEDKIHLCEEQASEDLVEKVRGELLRERVQRMEAQEGGFAQSLVALQFQKASRVTETLS 983
             +E+ +   EE    + + K   E L      +        +S  AL+ Q     T+   
Sbjct: 1498 ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1557

Query: 984  AYTALLSIQDLLLEELSASEMLTKSACTQILESHSRELQELERKLEDQLVQQEAA----Q 1039
                L + +D  L  L  +    K    + L++   + +E  R+L+ QL + E      +
Sbjct: 1558 LEDELQATEDAKLR-LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1616

Query: 1040 QQQALAS 1046
            +Q+ALA+
Sbjct: 1617 KQRALAA 1623



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 92/398 (23%), Positives = 168/398 (42%), Gaps = 48/398 (12%)

Query: 359  SLNDQMIDILSS-EDPGSMLQALEELEIATLNRADADLEACRTQISKDIIALLLKNLTSS 417
            +L  QM ++ +  E+    LQA E+ ++    R + +++A + Q  +D+ A   +N    
Sbjct: 1543 ALETQMEEMKTQLEELEDELQATEDAKL----RLEVNMQALKGQFERDLQARDEQNEEKR 1598

Query: 418  GHLSPQV---ERKMSAVFKKQFLLLENEIQEEYDRKMVALTAECDLETRKKMENQYQREM 474
              L  Q+   E ++    K++ L    + + E D K + L A+  ++ R++   Q ++  
Sbjct: 1599 RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQ 1658

Query: 475  MAMEEAEELLKRA-GERSAVECSNLLRTLHGLEQEHLRKSLA---LQQEEDFAKAHR--Q 528
              M++ +  L+ A   R  +  +         E E   KSL    +Q +ED A A R  +
Sbjct: 1659 AQMKDFQRELEDARASRDEIFAT-------AKENEKKAKSLEADLMQLQEDLAAAERARK 1711

Query: 529  LAVFQRNELHSIFFTQIKSAIFKGELKPEAAKMLLQNYSKIQENVEELMDFFQASKRYHL 588
             A  ++ EL      ++ S++       +  + L    ++++E +EE     +A     +
Sbjct: 1712 QADLEKEELAE----ELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD-RV 1766

Query: 589  SKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQK-----HERAGYLD--------- 634
             K     E L   L +  +  Q   S A  QL    ++     HE  G +          
Sbjct: 1767 RKATQQAEQLSNELATERSTAQKNES-ARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1825

Query: 635  -EDQMEMLLERAQTEVFSIKQKLDNDLKQEKKKLHQKLITKRRRELLQKHREQRREQASV 693
             E ++  L E+ + E    KQ     LKQ+ KKL + L+   + E  +K  EQ +EQA  
Sbjct: 1826 LEAKIAQLEEQVEQEARE-KQAATKSLKQKDKKLKEILL---QVEDERKMAEQYKEQAEK 1881

Query: 694  GEAFRTVEDAGQYLHQKRSLMEEHGATLEELQERLDQA 731
            G A   V+   + L +     +   A   +LQ  LD+A
Sbjct: 1882 GNA--RVKQLKRQLEEAEEESQRINANRRKLQRELDEA 1917



 Score = 40.8 bits (94), Expect = 0.009
 Identities = 107/532 (20%), Positives = 209/532 (39%), Gaps = 118/532 (22%)

Query: 663  EKKKLHQKLITKRRRELLQKHREQRREQASVGEAFRT----------------------- 699
            +K K  Q+      +EL QKH +   E+  + E  +                        
Sbjct: 869  QKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELE 928

Query: 700  ------------VEDAGQYLHQKRSLMEEHGATLEELQERLDQAALDDL---RTLTLSLF 744
                         ED GQ L  +R  M +    LEE  E  ++AA   L   +    +  
Sbjct: 929  EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE-EEAARQKLQLEKVTAEAKI 987

Query: 745  EKATDELRRL--QNSAMTQE--LLKRGVPWLF------------LQQILEEHGKEMAARA 788
            +K  DE+  +  QN+ +++E  LL+  +  L             L ++  +H   ++   
Sbjct: 988  KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE 1047

Query: 789  EQLEGEERDRDQEGVQSVRQRLKDDAP---EAVTEEQAELRRWEHLIFMK---LCSSVFS 842
             +L+ EE+ R +  ++ ++++L+ DA    E + + QA++   +  +  K   L +++  
Sbjct: 1048 VRLKKEEKSRQE--LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALAR 1105

Query: 843  LSEE-----ELLRMRQEVHGCFAQMDRSLALPKIRARVLLQQFQTAWREAEFVKLDQAVA 897
            L +E       L+  +E+ G  + +   L   +       +Q +    E E +K +    
Sbjct: 1106 LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE---L 1162

Query: 898  APELQQQSKVRKSRSKSKSKGELLKKCIEDKIHLCEEQASEDLVEKVRGELLRERVQRME 957
               L   +  ++ R+K + +  +LKK ++++    E Q  E  + +   + + E  +++E
Sbjct: 1163 EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE--MRQKHAQAVEELTEQLE 1220

Query: 958  AQEGGFAQSLVALQFQKA----SRVTETLSAYTALLSIQDLLLEELSASEMLTKSACTQI 1013
                         QF++A     +  +TL    A L           A E+       Q 
Sbjct: 1221 -------------QFKRAKANLDKNKQTLEKENADL-----------AGELRVLGQAKQE 1256

Query: 1014 LESHSREL----QELERKLEDQLVQQEAAQQQQALASWQQWVADGPGILNEP--GEVDSE 1067
            +E   ++L    QEL+ K  D   ++  A+    +   Q  V    G+LNE     +   
Sbjct: 1257 VEHKKKKLEAQVQELQSKCSDG--ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1314

Query: 1068 RQVSTVLHQALSKSQTLLEQHQQCLR--------EEQQNSVVLEDLLENMEA 1111
            + V+++  Q     + L E+ +Q L         EE++NS + + L E MEA
Sbjct: 1315 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS-LQDQLDEEMEA 1365


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 156/718 (21%), Positives = 300/718 (41%), Gaps = 103/718 (14%)

Query: 378  QALEEL--EIATLNRADADLEACRTQISKDIIALLLKNLTSSGHLSPQVERKMSAVFKKQ 435
            QA+EEL  ++    RA A+L+  +  + K+  A L   L   G    +VE K     KK+
Sbjct: 1203 QAVEELTEQLEQFKRAKANLDKNKQTLEKEN-ADLAGELRVLGQAKQEVEHK-----KKK 1256

Query: 436  FLLLENEIQEEYDRKMVALTAECDLETR-KKMENQYQREMMAMEEAE-ELLKRAGERSAV 493
               LE ++QE   +      A  +L  +  K++N+ +     + EAE + +K A  +   
Sbjct: 1257 ---LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA--KDVA 1311

Query: 494  ECSNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVFQRNELHSIFFTQIKSA----- 548
              S+ L+    L QE  R+ L +  +       RQL   +RN L      ++++      
Sbjct: 1312 SLSSQLQDTQELLQEETRQKLNVSTKL------RQLEE-ERNSLQDQLDEEMEAKQNLER 1364

Query: 549  -IFKGELKPEAAKMLLQNYSKIQENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSET 607
             I    ++   +K  LQ+++   E +EE    FQ     +L++++  +      L+ ++ 
Sbjct: 1365 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE-NLTQQYEEKAAAYDKLEKTKN 1423

Query: 608  RVQGLLSTAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLKQ-EKKK 666
            R+Q  L      L +   + +    L++ Q +     A+ +  S K   + D  + E ++
Sbjct: 1424 RLQQELDDLVVDLDN---QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1480

Query: 667  LHQKLITKRR--RELLQKHREQRRE----QASVGEAFRTVEDAGQYLHQ----KRSL--- 713
               K ++  R   E L+   E  R     +A + +   + +D G+ +H+    KR+L   
Sbjct: 1481 KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1540

Query: 714  MEEHGATLEELQERLDQAALDDLRTLTLSLFEKATDELRRLQNSAMTQELLKRGVPWLFL 773
            MEE    LEEL++ L QA  D    L +++        R LQ      E  +R      L
Sbjct: 1541 MEEMKTQLEELEDEL-QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ-----L 1594

Query: 774  QQILEEHGKEM----------AARAEQLEGEERDRDQEGVQSVRQRLKDDAPEAVTEEQA 823
            Q+ L E+  E+          AA  ++LEG+ +D + +   +++ R  ++A + + + QA
Sbjct: 1595 QRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGR--EEAIKQLRKLQA 1652

Query: 824  ELRRWEHLIFMKLCSSVFSLSEEELLRMRQEVHGCFAQMDRSLALPKIRARVLLQQFQTA 883
            +++ ++  +             E+    R E+     + ++     +     L +    A
Sbjct: 1653 QMKDFQREL-------------EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1699

Query: 884  WREAEFVKLDQAVAAPELQQQSKVRKSRSKSKSKGELLKKCIEDKIHLCEEQASEDLV-- 941
             R  +   L++   A EL      R +    K + E     +E+++   EEQ + + +  
Sbjct: 1700 ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE--EEQGNMEAMSD 1757

Query: 942  ---------EKVRGELLRERV---------QRMEAQEGGFAQSLVALQFQKASRVTETLS 983
                     E++  EL  ER          Q++E Q       L  ++    S+   T++
Sbjct: 1758 RVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA 1817

Query: 984  AYTALLSIQDLLLEELSASEMLTKSACTQILESHSRELQELERKLEDQLVQQEAAQQQ 1041
            A  A ++     LEE    E   K A T+ L+   ++L+E+  ++ED+    E  ++Q
Sbjct: 1818 ALEAKIA----QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQ 1871



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 111/461 (24%), Positives = 186/461 (40%), Gaps = 103/461 (22%)

Query: 670  KLITKRRRELLQKHREQRREQASVGEAFRTVEDAGQYLHQKRSLMEEHGATLEE---LQE 726
            +L TK +  LLQ  R++   QA   E  +T E   +  ++ + L ++H    EE   LQE
Sbjct: 836  RLFTKVK-PLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE 894

Query: 727  RLDQAALDDLRTLTLSLFEKATDELRRLQNSAMTQELLKRGVPWLFLQQILEEHGKEMAA 786
            +L              L+ +A  E  R++ +A  QE              LEE   EM A
Sbjct: 895  QLQAET---------ELYAEA--EEMRVRLAAKKQE--------------LEEILHEMEA 929

Query: 787  RAEQLEGEERDRDQEGVQSVRQRLKDDAPEAVTEEQAELRRWEHLIFMKLCSSVFSLSEE 846
            R E    EE DR Q+ +Q+ R+++     +   EEQ                    L EE
Sbjct: 930  RLE----EEEDRGQQ-LQAERKKMAQQMLD--LEEQ--------------------LEEE 962

Query: 847  ELLRMRQEVHGCFAQMDRSLALPKIRARVLLQQFQTAWREAEFVKLDQAVA--APELQQQ 904
            E  R + ++    A+      + K+   +L+   Q      E   L++ ++     L ++
Sbjct: 963  EAARQKLQLEKVTAE----AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1018

Query: 905  SKVRKSRSKSKSKGELLKKCIEDKIHLCEEQASEDLVEKVRGEL------LRERVQRMEA 958
             +  K+ +K K+K E +   +E  + L +E+ S   +EK++ +L        E++  ++A
Sbjct: 1019 EEKAKNLTKLKNKHESMISELE--VRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1076

Query: 959  QEGGFAQSLV----ALQFQKASRVTETLSAYTALLSIQDLL-----LEELSASEMLTKSA 1009
            Q       L      LQ   A    E      AL  I++L      L+E   SE   ++ 
Sbjct: 1077 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK 1136

Query: 1010 CTQILESHSRELQELERKLEDQLVQQEAAQQQQALASWQQWVADGPGILNEPGEVDSERQ 1069
              +       EL+ L+ +LED L     A QQ+  A  +Q V                  
Sbjct: 1137 AEKQKRDLGEELEALKTELEDTL--DSTATQQELRAKREQEV------------------ 1176

Query: 1070 VSTVLHQALSKSQTLLEQHQQCLREEQQNSVVLEDLLENME 1110
              TVL +AL +     E   Q +R  Q+++  +E+L E +E
Sbjct: 1177 --TVLKKALDEETRSHEAQVQEMR--QKHAQAVEELTEQLE 1213



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 135/727 (18%), Positives = 291/727 (40%), Gaps = 74/727 (10%)

Query: 360  LNDQMIDILSSEDPGSMLQALEELEIATLNRADADLEACRTQISKDIIALLLKNLTSSGH 419
            L++    +   ED G  LQA  +     +   +  LE       K    L L+ +T+   
Sbjct: 924  LHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK----LQLEKVTAEAK 979

Query: 420  LSPQVERKMSAVFKKQFLLLENEIQEEYDRKMVALTAECDLETRKKMENQYQREMMAMEE 479
            +    +  +    +   L  E ++ EE    +    AE + + +   + + + E M + E
Sbjct: 980  IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESM-ISE 1038

Query: 480  AEELLKRAGERSAVECSNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVFQRNELHS 539
             E  LK+  E+S  E   L R L G   +   +   LQ +   A+   QLA  ++ E   
Sbjct: 1039 LEVRLKKE-EKSRQELEKLKRKLEGDASDFHEQIADLQAQ--IAELKMQLA--KKEEELQ 1093

Query: 540  IFFTQIKSAIFKGELKPEAAKMLLQNYSKIQENVEELMDFFQASKRYHLSKRFGHREYLV 599
                ++   I +     +  + L  + S +QE+++        S+R   +K    +  L 
Sbjct: 1094 AALARLDDEIAQKNNALKKIRELEGHISDLQEDLD--------SERAARNKAEKQKRDLG 1145

Query: 600  QNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDND 659
            + L++ +T ++  L + A Q   L  K E+   + +  ++      + +V  ++QK    
Sbjct: 1146 EELEALKTELEDTLDSTATQ-QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1204

Query: 660  LKQEKKKLHQKLITKRRRELLQKHREQ-RREQASVGEAFRTVEDAGQYLHQKRSLMEEHG 718
            +++  ++L Q    KR +  L K+++   +E A +    R +  A Q +  K+  +E   
Sbjct: 1205 VEELTEQLEQ---FKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE--- 1258

Query: 719  ATLEELQERLD-----QAALDDLRTLTLSLFEKATDELRRLQNSA--MTQELLKRGVPWL 771
            A ++ELQ +       +A L+D      +  E  T  L   +  A  + +++        
Sbjct: 1259 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1318

Query: 772  FLQQILEEHGKE---MAARAEQLEGEER------DRDQEGVQSV--------------RQ 808
              Q++L+E  ++   ++ +  QLE E        D + E  Q++              ++
Sbjct: 1319 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1378

Query: 809  RLKDDAPEAVTEEQAELRRWEHLIFM----KLCSSVFSLSEEELLRMRQEVHGCFAQMDR 864
            +L+D A      E+ + R  + +  +    +  ++ +   E+   R++QE+      +D 
Sbjct: 1379 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1438

Query: 865  SLALPKIRARVLLQQFQTAWREAEFVKLDQA-VAAPELQQQSKVRKSRSKSKSKGELLKK 923
                     R L+   +   R+ + +  ++  +++    ++ +      + ++K   L +
Sbjct: 1439 Q--------RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1490

Query: 924  CIEDKIHLCEEQASEDLVEKVRGELLRERVQRMEAQEGGFAQSLVALQFQKASRVTETLS 983
             +E+ +   EE    + + K   E L      +        +S  AL+ Q     T+   
Sbjct: 1491 ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1550

Query: 984  AYTALLSIQDLLLEELSASEMLTKSACTQILESHSRELQELERKLEDQLVQQEAA----Q 1039
                L + +D  L  L  +    K    + L++   + +E  R+L+ QL + E      +
Sbjct: 1551 LEDELQATEDAKLR-LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1609

Query: 1040 QQQALAS 1046
            +Q+ALA+
Sbjct: 1610 KQRALAA 1616



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 92/398 (23%), Positives = 168/398 (42%), Gaps = 48/398 (12%)

Query: 359  SLNDQMIDILSS-EDPGSMLQALEELEIATLNRADADLEACRTQISKDIIALLLKNLTSS 417
            +L  QM ++ +  E+    LQA E+ ++    R + +++A + Q  +D+ A   +N    
Sbjct: 1536 ALETQMEEMKTQLEELEDELQATEDAKL----RLEVNMQALKGQFERDLQARDEQNEEKR 1591

Query: 418  GHLSPQV---ERKMSAVFKKQFLLLENEIQEEYDRKMVALTAECDLETRKKMENQYQREM 474
              L  Q+   E ++    K++ L    + + E D K + L A+  ++ R++   Q ++  
Sbjct: 1592 RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQ 1651

Query: 475  MAMEEAEELLKRA-GERSAVECSNLLRTLHGLEQEHLRKSLA---LQQEEDFAKAHR--Q 528
              M++ +  L+ A   R  +  +         E E   KSL    +Q +ED A A R  +
Sbjct: 1652 AQMKDFQRELEDARASRDEIFAT-------AKENEKKAKSLEADLMQLQEDLAAAERARK 1704

Query: 529  LAVFQRNELHSIFFTQIKSAIFKGELKPEAAKMLLQNYSKIQENVEELMDFFQASKRYHL 588
             A  ++ EL      ++ S++       +  + L    ++++E +EE     +A     +
Sbjct: 1705 QADLEKEELAE----ELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD-RV 1759

Query: 589  SKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQK-----HERAGYLD--------- 634
             K     E L   L +  +  Q   S A  QL    ++     HE  G +          
Sbjct: 1760 RKATQQAEQLSNELATERSTAQKNES-ARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1818

Query: 635  -EDQMEMLLERAQTEVFSIKQKLDNDLKQEKKKLHQKLITKRRRELLQKHREQRREQASV 693
             E ++  L E+ + E    KQ     LKQ+ KKL + L+   + E  +K  EQ +EQA  
Sbjct: 1819 LEAKIAQLEEQVEQEARE-KQAATKSLKQKDKKLKEILL---QVEDERKMAEQYKEQAEK 1874

Query: 694  GEAFRTVEDAGQYLHQKRSLMEEHGATLEELQERLDQA 731
            G A   V+   + L +     +   A   +LQ  LD+A
Sbjct: 1875 GNA--RVKQLKRQLEEAEEESQRINANRRKLQRELDEA 1910



 Score = 40.8 bits (94), Expect = 0.009
 Identities = 107/532 (20%), Positives = 209/532 (39%), Gaps = 118/532 (22%)

Query: 663  EKKKLHQKLITKRRRELLQKHREQRREQASVGEAFRT----------------------- 699
            +K K  Q+      +EL QKH +   E+  + E  +                        
Sbjct: 862  QKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELE 921

Query: 700  ------------VEDAGQYLHQKRSLMEEHGATLEELQERLDQAALDDL---RTLTLSLF 744
                         ED GQ L  +R  M +    LEE  E  ++AA   L   +    +  
Sbjct: 922  EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE-EEAARQKLQLEKVTAEAKI 980

Query: 745  EKATDELRRL--QNSAMTQE--LLKRGVPWLF------------LQQILEEHGKEMAARA 788
            +K  DE+  +  QN+ +++E  LL+  +  L             L ++  +H   ++   
Sbjct: 981  KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE 1040

Query: 789  EQLEGEERDRDQEGVQSVRQRLKDDAP---EAVTEEQAELRRWEHLIFMK---LCSSVFS 842
             +L+ EE+ R +  ++ ++++L+ DA    E + + QA++   +  +  K   L +++  
Sbjct: 1041 VRLKKEEKSRQE--LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALAR 1098

Query: 843  LSEE-----ELLRMRQEVHGCFAQMDRSLALPKIRARVLLQQFQTAWREAEFVKLDQAVA 897
            L +E       L+  +E+ G  + +   L   +       +Q +    E E +K +    
Sbjct: 1099 LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE---L 1155

Query: 898  APELQQQSKVRKSRSKSKSKGELLKKCIEDKIHLCEEQASEDLVEKVRGELLRERVQRME 957
               L   +  ++ R+K + +  +LKK ++++    E Q  E  + +   + + E  +++E
Sbjct: 1156 EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE--MRQKHAQAVEELTEQLE 1213

Query: 958  AQEGGFAQSLVALQFQKA----SRVTETLSAYTALLSIQDLLLEELSASEMLTKSACTQI 1013
                         QF++A     +  +TL    A L           A E+       Q 
Sbjct: 1214 -------------QFKRAKANLDKNKQTLEKENADL-----------AGELRVLGQAKQE 1249

Query: 1014 LESHSREL----QELERKLEDQLVQQEAAQQQQALASWQQWVADGPGILNEP--GEVDSE 1067
            +E   ++L    QEL+ K  D   ++  A+    +   Q  V    G+LNE     +   
Sbjct: 1250 VEHKKKKLEAQVQELQSKCSDG--ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1307

Query: 1068 RQVSTVLHQALSKSQTLLEQHQQCLR--------EEQQNSVVLEDLLENMEA 1111
            + V+++  Q     + L E+ +Q L         EE++NS + + L E MEA
Sbjct: 1308 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS-LQDQLDEEMEA 1358


>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
          Length = 1498

 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 158/756 (20%), Positives = 301/756 (39%), Gaps = 122/756 (16%)

Query: 461  ETRKKMENQYQREMMAMEEAEELLKRAGERSA--------VECSNLLRT--LHGLEQEHL 510
            E +  +E   QR +   E   E L+R  + +A        V+ + L R   L  L+QEHL
Sbjct: 661  EAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHL 720

Query: 511  --RKSLALQQEEDFAKAHRQLAVFQRNELHSIFFTQIKSAIFKGELKPEAAKM-----LL 563
               K L L QE       + L   Q +      + ++++ +  GEL+ EAA       LL
Sbjct: 721  DLMKQLTLTQEA-LQSREQSLDALQTH------YDELQARL--GELQGEAASREDTICLL 771

Query: 564  QNYSKIQENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSET--RVQGLLSTAAAQLT 621
            QN   I E         QA+K        G R       ++SET  +++  L+  + Q+ 
Sbjct: 772  QNEKIILEAA------LQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVE 825

Query: 622  HLIQKHERAG-YLDEDQMEMLLERAQTEVF----SIKQKLDNDLKQEKKKLHQKLITKRR 676
            HL Q+       + + + + L ++   E +    + K +L ++LK  +K+L  +L  + R
Sbjct: 826  HLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSEL-KELR 884

Query: 677  RELLQKHREQRREQASVGEAFRTVEDAGQYLHQKRSLMEEHGATLEELQERLDQAALDDL 736
            +EL+Q H E+R  +A +    R V    Q++      ++      +E++  L     D  
Sbjct: 885  QELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKE 944

Query: 737  RTLTLS----LFEKATDELRRLQNSAMT---QELLKRGVPWLFLQQILEEHGKE------ 783
            + + ++      +K  +EL++    A+T   Q++ + G      Q+ ++   K       
Sbjct: 945  QMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVG 1004

Query: 784  -MAARAEQLEGEERDRDQEGVQSVRQRLKDDAPEAVTEE----QAELRRWEH--LIFMKL 836
             ++ R ++    +   D E  Q   Q    D+  A+ E     +AEL+   H   +  K 
Sbjct: 1005 ILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKE 1064

Query: 837  CSSVFSLSEEELLRMRQEVHGCFAQMDRSLALPK-------------------------- 870
               V +L+ +EL   R++V     ++  S    K                          
Sbjct: 1065 LQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGL 1124

Query: 871  ------IRARVLLQQFQTAWREAEFVKLDQAVAAPELQQQSKVRKSRSKSKSKGELLKKC 924
                  +R    + +   A REA+ V+L+  V A   +++ + R+ +   ++    L+K 
Sbjct: 1125 GQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEK- 1183

Query: 925  IEDKIHLCEEQASEDLVEKVRGELLRERVQRMEAQEGGFAQSLVALQFQKASRVTETLSA 984
                    E++    L E+V    +     R   +      S V  + Q    + + L A
Sbjct: 1184 --------EKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQA 1235

Query: 985  YTALLSIQDLLLEELSASEMLTKSACTQILESHSRELQELERKLEDQLVQQEAAQQQQAL 1044
                    DL + E   S+ + +    ++ E+ + +LQ L+++L++QL +Q    Q+   
Sbjct: 1236 -----EADDLQIREGKHSQEIAQFQ-AELAEARA-QLQLLQKQLDEQLSKQPVGNQEMEN 1288

Query: 1045 ASWQ--------QWVADGPGILNEPGEVDSERQVSTVLHQALSKSQTLLEQHQQCLREEQ 1096
              W+        Q +     +  + G  + E      L Q L   ++ LE  Q+ L   Q
Sbjct: 1289 LKWEVDQKEREIQSLKQQLDLTEQQGRKELEG-----LQQLLQNVKSELEMAQEDLSMTQ 1343

Query: 1097 QNSVVLEDLLENMEADTFATLCSQELRLASYLARMA 1132
            ++  +L+  +  ++ +   TL  Q  +L   L R A
Sbjct: 1344 KDKFMLQAKVSELK-NNMKTLLQQNQQLKLDLRRGA 1378



 Score = 34.3 bits (77), Expect = 0.80
 Identities = 55/281 (19%), Positives = 124/281 (44%), Gaps = 23/281 (8%)

Query: 843  LSEEELLRMRQEVHGCFAQMDRSLALPKIRARVLLQQFQTAWREAEFVKLDQAVAAPELQ 902
            ++EE+  R+  +V      M RS+         L QQ      + + V+L++        
Sbjct: 507  VAEEQYQRLMAKVE----DMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLT---- 558

Query: 903  QQSKVRKSRSKSKSKGELLKKCIEDKIHLCEEQASEDLVEKVRGELLRERVQRMEAQEGG 962
              SK++ S+++  S  + +++  + ++ L +E        +++GE+   +V +M   + G
Sbjct: 559  --SKLKASQAEISSL-QSVRQWYQQQLALAQEARV-----RLQGEMAHIQVGQMT--QAG 608

Query: 963  FAQSLVALQFQKASRVTETLSAYTALLSIQDLLLEELSASEMLTKSACTQILESHSRELQ 1022
              + L       + ++TET              L+ + A  +  ++A  QI E+ +   +
Sbjct: 609  LLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEE 668

Query: 1023 ELERKLEDQLVQQEAAQQ--QQALASWQQWVADGPGILNEPGEVDSERQVSTVLHQALSK 1080
            +L+R+LE+   ++E  Q+    A +  QQ       +L    ++++ +Q    L + L+ 
Sbjct: 669  DLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTL 728

Query: 1081 SQTLLEQHQQCLREEQQNSVVLEDLLENMEADTFA---TLC 1118
            +Q  L+  +Q L   Q +   L+  L  ++ +  +   T+C
Sbjct: 729  TQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTIC 769


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 152/738 (20%), Positives = 295/738 (39%), Gaps = 135/738 (18%)

Query: 379  ALEEL--EIATLNRADADLEACRTQISKDIIALLLKNLTSSGHLSPQVERKMSAVFKKQF 436
            ALEEL  ++    R  A+LE  +  +  D      K L     +  QV+ +     KK  
Sbjct: 1204 ALEELSEQLEQAKRFKANLEKNKQGLETDN-----KELACEVKVLQQVKAESEHKRKK-- 1256

Query: 437  LLLENEIQE------EYDRKMVALTAECDLETRKKMENQYQREMMAMEEAEEL-LKRAGE 489
              L+ ++QE      E DR  V L      E   K++N+       +EEAE+  +K A +
Sbjct: 1257 --LDAQVQELHAKVSEGDRLRVELA-----EKASKLQNELDNVSTLLEEAEKKGIKFAKD 1309

Query: 490  RSAVECSNLLRTLHGLEQEHLRKSLAL-----------------QQEEDFAKAHRQLAVF 532
             +++E    L+    L QE  R+ L L                 Q+EE+ A+ + +  V 
Sbjct: 1310 AASLESQ--LQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVL 1367

Query: 533  QRNELHSIFFTQIKSAIFKGELKPEAAKMLLQNYSKIQENVEE---LMDFFQASKRY--- 586
                  +    ++   +   E   EA K LL++   + + +EE     D  + +K     
Sbjct: 1368 ALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQ 1427

Query: 587  ---HLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDE-DQMEMLL 642
                L+    H+  +  NL+  + +   LL+          +K   A Y +E D+ E   
Sbjct: 1428 ELDDLTVDLDHQRQVASNLEKKQKKFDQLLAE---------EKSISARYAEERDRAEAEA 1478

Query: 643  ERAQTEVFSIKQKLDNDLKQEKKKLHQKLITKRRRELLQKHREQRREQASVGEAFRTVED 702
               +T+  S+ + L+  L+ ++                +  R+ ++ +A + +   + +D
Sbjct: 1479 REKETKALSLARALEEALEAKE----------------EFERQNKQLRADMEDLMSSKDD 1522

Query: 703  AGQYLHQ----KRSL---MEEHGATLEELQERLDQAALDDLRTLTLSLFEKATDELRRLQ 755
             G+ +H+    KR+L   +EE    LEEL++ L QA  D    L +++        R LQ
Sbjct: 1523 VGKNVHELEKSKRALEQQVEEMRTQLEELEDEL-QATEDAKLRLEVNMQAMKAQFERDLQ 1581

Query: 756  NSAMTQELLKRGVPWLFLQQI------LEEHGKEMAARAEQLEGEERD-RDQEGVQSVRQ 808
                  E  KR    L ++Q+      LE+  K+ A      +  E D +D E       
Sbjct: 1582 TRDEQNEEKKR----LLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAAN 1637

Query: 809  RLKDDAPEAVTEEQAELRRWEHLIFMKLCSSVFSLSEEELLRMRQEVHGCFAQMDRSLAL 868
            + +D+  + + + QA+++ ++  +             EE    R E+     + ++ L  
Sbjct: 1638 KARDEVIKQLRKLQAQMKDYQREL-------------EEARASRDEIFAQSKESEKKLKS 1684

Query: 869  PKIRARVLLQQFQTAWREAEFVKLDQAVAAPELQQQSKVRKSRSKSKSKGELLKKCIEDK 928
             +     L ++  ++ R     + ++   A E+   +  + +    K + E     +E++
Sbjct: 1685 LEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEE 1744

Query: 929  IHLCEEQASEDL-----------VEKVRGELLRERV---------QRMEAQEGGFAQSLV 968
            +   EEQ++ +L           V+ +  EL  ER          Q++E Q       L 
Sbjct: 1745 LE--EEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQ 1802

Query: 969  ALQFQKASRVTETLSAYTALLSIQDLLLEELSASEMLTKSACTQILESHSRELQELERKL 1028
             L+    S+   T+SA  A +      LEE    E   ++A  +++    ++L+E+  ++
Sbjct: 1803 ELEGAVKSKFKATISALEAKIG----QLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQV 1858

Query: 1029 EDQLVQQEAAQQQQALAS 1046
            ED+    +  ++Q   A+
Sbjct: 1859 EDERRHADQYKEQMEKAN 1876



 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 173/819 (21%), Positives = 323/819 (39%), Gaps = 123/819 (15%)

Query: 337  WQYESKLEPLPFTSADGVNEDLSLNDQMIDILSSEDPGSMLQA-LEELEIATLNRADADL 395
            W+  +K++PL   +     E+L   D+  ++L  ++  + ++  LEE+E     +    L
Sbjct: 835  WRVFTKVKPLLQVTRQ--EEELQAKDE--ELLKVKEKQTKVEGELEEME----RKHQQLL 886

Query: 396  EACRTQISKDIIALLLKNLTSSGHLSPQVERKMSAVFKKQFLL-----LENEIQEEYDRK 450
            E       K+I+A  L+  T     + ++  +++A  KKQ L      LE+ ++EE +R 
Sbjct: 887  E------EKNILAEQLQAETELFAEAEEMRARLAA--KKQELEEILHDLESRVEEEEERN 938

Query: 451  MVALTAECDLETR-KKMENQYQREMMAMEE-------AEELLKRAGERSAV---ECSNLL 499
             +    +  ++   + +E Q   E  A ++       AE  +K+  E   +   + S  +
Sbjct: 939  QILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFI 998

Query: 500  RTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVFQRNELHSIFFTQIKSAIFKGELKPEAA 559
            +    +E      S  L +EE+ AK   ++   Q   +  +     K    + EL+ +A 
Sbjct: 999  KEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELE-KAK 1057

Query: 560  KMLLQNYSKIQENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQ 619
            + L    + +Q+ + EL                   + L   L   E  +QG L+    +
Sbjct: 1058 RKLDGETTDLQDQIAELQ---------------AQIDELKLQLAKKEEELQGALARGDDE 1102

Query: 620  LTH----LIQKHERAGYLDEDQMEMLLERA-QTEVFSIKQKLDNDLKQEKKKLHQKLITK 674
              H    L    E    + E Q +   E+A + +    K+ L  +L+  K +L   L T 
Sbjct: 1103 TLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTT 1162

Query: 675  RRRELLQKHREQRREQASVGEAFRTVEDAGQYLHQKRSLMEEHGATLEELQERLDQAAL- 733
              ++ L+  REQ  E A + +A    E+   +  Q + + + H   LEEL E+L+QA   
Sbjct: 1163 AAQQELRTKREQ--EVAELKKALE--EETKNHEAQIQDMRQRHATALEELSEQLEQAKRF 1218

Query: 734  ------------DDLRTLTLSL----FEKATDELRRLQNSAMTQELLKRGVPWLFLQQIL 777
                         D + L   +      KA  E +R +  A  QEL  +      L+  L
Sbjct: 1219 KANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVEL 1278

Query: 778  EEHGKEMAARAEQLEGEERDRDQEGVQSVRQRLKDDAP-EAVTEEQAELRRWEHLIFMKL 836
             E   ++    + +     + +++G++      KD A  E+  ++  EL + E    + L
Sbjct: 1279 AEKASKLQNELDNVSTLLEEAEKKGIKFA----KDAASLESQLQDTQELLQEETRQKLNL 1334

Query: 837  CSSVFSLSEEELLRMRQEVHGCFAQMDRSLALPKIRARVLLQQFQTAWREAEFVKLDQAV 896
             S +  L EE+     Q       Q +   A   +  +VL  Q Q A  +    K+D  +
Sbjct: 1335 SSRIRQLEEEKNSLQEQ-------QEEEEEARKNLEKQVLALQSQLADTKK---KVDDDL 1384

Query: 897  AAPELQQQSKVRKSRSKSKSKGELLKKCIEDKIHLCEEQASEDLVEKVRGELLRERVQRM 956
               E           S  ++K +LLK        L E+  + D +EK +  L +E     
Sbjct: 1385 GTIE-----------SLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLT 1433

Query: 957  EAQEGGFAQSLVALQFQKASRVTETLSAYTALLSIQDLLLEELSASEMLTKSACTQILES 1016
               +    Q  VA   +K  +                LL EE S S    +       E+
Sbjct: 1434 VDLD---HQRQVASNLEKKQK------------KFDQLLAEEKSISARYAEERDRAEAEA 1478

Query: 1017 HSRELQ--ELERKLEDQLVQQEAAQQQ--QALASWQQWVADGPGILNEPGEVDSERQVST 1072
              +E +   L R LE+ L  +E  ++Q  Q  A  +  ++    +     E++  ++   
Sbjct: 1479 REKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKR--- 1535

Query: 1073 VLHQALSKSQTLLEQHQQCLREEQQNSVVLEDLLENMEA 1111
             L Q + + +T LE+ +  L+  +   + LE  ++ M+A
Sbjct: 1536 ALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKA 1574



 Score = 51.6 bits (122), Expect = 5e-06
 Identities = 98/456 (21%), Positives = 189/456 (41%), Gaps = 55/456 (12%)

Query: 377  LQALEELEIATLNRADADLEACRTQISKDIIALLLKNLTSSGHLSPQV---ERKMSAVFK 433
            LQA E+ ++    R + +++A + Q  +D+     +N      L  QV   E ++    K
Sbjct: 1555 LQATEDAKL----RLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERK 1610

Query: 434  KQFLLLENEIQEEYDRKMVALTAECDLETRKKMENQYQREMMAMEEAEELLKRAG---ER 490
            ++ L + ++ + E D K +    E   + R ++  Q ++    M++ +  L+ A    + 
Sbjct: 1611 QRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDE 1670

Query: 491  SAVECSNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVFQRNELHSIFFTQI--KSA 548
               +     + L  LE E L+    LQ+E   ++  R+ A  +R+EL          KSA
Sbjct: 1671 IFAQSKESEKKLKSLEAEILQ----LQEELASSERARRHAEQERDELADEITNSASGKSA 1726

Query: 549  IFKGELKPEAAKMLLQNYSKIQENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETR 608
            +   + + EA        ++++E +EE     + S    L+ RF          + +  +
Sbjct: 1727 LLDEKRRLEA------RIAQLEEELEE-----EQSNMELLNDRF----------RKTTLQ 1765

Query: 609  VQGLLSTAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLKQEKKKLH 668
            V  L +  AA+ +   QK + A    E Q + L  + Q    ++K K    +   + K+ 
Sbjct: 1766 VDTLNAELAAERS-AAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIG 1824

Query: 669  Q--KLITKRRRELLQKHREQRREQASVGEAFRTVEDAGQYLHQKRSLMEEHGATLEELQE 726
            Q  + + +  +E    ++  RR +  + E F  VED  ++  Q +  ME+  A +++L+ 
Sbjct: 1825 QLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKR 1884

Query: 727  RLDQA------ALDDLRTLTLSLFEKATDELRRLQNSAMT-QELLKRGVPWLFLQQILEE 779
            +L++A      A    R L   L + AT+    L     T +  L+RG P  F       
Sbjct: 1885 QLEEAEEEATRANASRRKLQREL-DDATEANEGLSREVSTLKNRLRRGGPISF------- 1936

Query: 780  HGKEMAARAEQLEGEERDRDQEGVQSVRQRLKDDAP 815
                   R   LEG   +   +  +S    + +  P
Sbjct: 1937 SSSRSGRRQLHLEGASLELSDDDTESKTSDVNETQP 1972


>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
            sapiens]
          Length = 668

 Score = 71.6 bits (174), Expect = 5e-12
 Identities = 135/649 (20%), Positives = 274/649 (42%), Gaps = 116/649 (17%)

Query: 415  TSSGHLSPQVERKMSAVFKKQFLLLENEIQEEYDRKMVALTAECDLETRKKMENQYQREM 474
            TS G  SP+ E+K S           ++ QE   R++ A      + T +K E Q     
Sbjct: 100  TSGGCHSPEDEQKAS-----------HQHQEALRRELEAQVHTIRILTCQKTELQ----- 143

Query: 475  MAMEEAEELLKRAGERSAVECSNLLRTLHGL-----EQEHLRKSLALQQEEDFAKAHRQL 529
            MA+  ++  +K+       E  +L+  LH       E E    ++A Q++    KA R +
Sbjct: 144  MALYYSQHAVKQLEG----EARDLISRLHDSWKFAGELEQALSAVATQKK----KADRYI 195

Query: 530  AVFQRNELHSIFFTQIKSAIFKGELKPEAAKM------LLQNYSKIQENVEELMDFFQAS 583
                + E  ++     ++ I   ELK + AK+      +    S+IQ NV+EL       
Sbjct: 196  EELTK-ERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKEL------- 247

Query: 584  KRYHLSKRFGHREYLV---QNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDEDQMEM 640
                  KR   R  L+   Q LQ+    +   L + +A+L   ++++E    L++ Q E 
Sbjct: 248  ------KRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEK 301

Query: 641  LL---ERAQTEVFSIKQKLDNDLKQEKKKLHQKLITKRRRELLQKHREQRREQASVGEAF 697
            +    E+ Q     I+++ +   +QE+K   Q+   +R+ E++ +  E+ R Q  +    
Sbjct: 302  MWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEM---- 357

Query: 698  RTVEDAGQYLHQKRSLMEEHGATLEELQERLDQAALDDLRTLTLSLFEKATDELRRLQNS 757
              + +  + + +   +M E    + EL+E++ +              EK  ++  + Q  
Sbjct: 358  --MWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQ-------------EKIREQEEKRQEE 402

Query: 758  AMTQELLKR----GVPWLFLQQILEEHGKEMAARAEQLEGEERDRDQEGVQSVRQRLKDD 813
               +E  KR       W   ++I E+  K      +    EE+  +QE    +R+  K  
Sbjct: 403  EKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQE---KIREEEKRQ 459

Query: 814  APEAVTEEQAELRRWEHLIFMKLCSSVFSLSEEELLRMRQEVHGCFAQMDRSLALPKIRA 873
              E +  ++ ++R  E +   K       + E+E +R ++E      ++ R       + 
Sbjct: 460  EQEEMWRQEEKIREQEEIWRQKE-----KMHEQEKIRKQEE------KVWRQEEKMHDQE 508

Query: 874  RVLLQQFQTAWREAEFVKLDQAVAAPELQQQSKVRKSRSKSKSKGELLKKCIEDKIHLCE 933
              + +Q +  WR+ E ++          +Q+ K+R+   K + + E++++  E+K+   E
Sbjct: 509  EKIREQEEKMWRQEEKIR----------EQEEKIREQEEKIREQEEMMQEQ-EEKMGEQE 557

Query: 934  EQASEDLVEKVRGELLRERVQRMEAQEGGFAQSLVALQFQKASRVTETLSAYTALLSIQD 993
            E+  E    + + E +RE+ +++  Q+    +     Q +K     E +     ++  Q+
Sbjct: 558  EKMQEQEKMRRQEEKIREQEEKIREQKEKIRE-----QEEKIWEQEEKIREQEEMMQEQE 612

Query: 994  LLLEELSASEMLTKSACTQILESHSRELQELERKLEDQLVQQEAAQQQQ 1042
               E++   E   +  C Q  E   +E +E  R+ E+++ +QE   +QQ
Sbjct: 613  ---EKMWEQE---EKMCEQ--EEKMQEQEEKMRRQEEKMWEQEVRLRQQ 653



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 92/466 (19%), Positives = 211/466 (45%), Gaps = 60/466 (12%)

Query: 657  DNDLKQEKKKLHQKLITKRRRELLQKHREQRREQASVGEAFRTVEDAGQYLHQKRSLME- 715
            D +LK++  KL +KL      +L++   E+   Q +V E  R +E A   L Q++   E 
Sbjct: 216  DEELKEKNAKLQEKL------QLVES--EKSEIQLNVKELKRKLERAKLLLPQQQLQAEA 267

Query: 716  EH-GATLEELQERLDQAALDDLRTLTLSLFEKATDELRRLQNSAMTQELLKRGVPWLFLQ 774
            +H G  L+ +  +L QA +++             +EL    N    +++ ++       +
Sbjct: 268  DHLGKELQSVSAKL-QAQVEE-------------NELWNRLNQQQEEKMWRQEEKIQEWE 313

Query: 775  QILEEHGKEMAARAEQL-EGEERDRDQEGVQSVRQRLKDDAPEAVTEEQAELRRWEHLIF 833
            + ++E  +++  + E++ E EE+ R QE +   ++       E + E++ ++RR E +++
Sbjct: 314  EKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMW 373

Query: 834  MKLCSSVFSLSEEELLRMRQEVHGCFAQMDRSLALPKIRARVLLQQFQTAWREAEFVKLD 893
             K         EE++  + +++H             KIR +   +Q +   RE E     
Sbjct: 374  EK---------EEKIRELEEKMH----------EQEKIREQEEKRQEEEKIREQE---KR 411

Query: 894  QAVAAPELQQQSKVRKSRSKSKSKGELLKKCIEDKIH----LCEEQASEDLVEKVR-GEL 948
            Q   A   +Q+ K+R+   K + + + + +  E+KIH    + EE+  ++  E  R  E 
Sbjct: 412  QEQEAKMWRQEEKIREQEEKIREQEKKMWR-QEEKIHEQEKIREEEKRQEQEEMWRQEEK 470

Query: 949  LRERVQRMEAQEGGFAQSLVALQFQKASRVTETLSAYTALLSIQDLLLEELSASEMLTKS 1008
            +RE+ +    +E    Q  +  Q +K  R  E +      +  Q+   E++   E   + 
Sbjct: 471  IREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQE---EKMWRQEEKIRE 527

Query: 1009 ACTQILESHS--RELQELERKLEDQL-VQQEAAQQQQALASWQQWVADGPGILNEPGE-V 1064
               +I E     RE +E+ ++ E+++  Q+E  Q+Q+ +   ++ + +    + E  E +
Sbjct: 528  QEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKI 587

Query: 1065 DSERQVSTVLHQALSKSQTLLEQHQQCLREEQQNSVVLEDLLENME 1110
              + +      + + + + ++++ ++ + E+++     E+ ++  E
Sbjct: 588  REQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQE 633



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 97/510 (19%), Positives = 204/510 (40%), Gaps = 80/510 (15%)

Query: 355 NEDLSLNDQMIDILSSEDPGSMLQALEELEIATLNRADADLEACRTQISKDIIALLLKNL 414
           N  L    Q+++   SE   ++ +   +LE A L      L+A    + K++ ++  K  
Sbjct: 223 NAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQ 282

Query: 415 TSS------GHLSPQVERKMSAVFKKQFLLLENEIQEEYDRKMVALTAECDLETRKKMEN 468
                      L+ Q E KM    +K     E +IQE+ ++       E + + R++ E 
Sbjct: 283 AQVEENELWNRLNQQQEEKMWRQEEK-IQEWEEKIQEQEEK-----IREQEEKIREQEEK 336

Query: 469 QYQREMMAMEEAEELLKRAGERSAVECSNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQ 528
             ++E M  E+ E++  R  E    E    +R L  +  E   K   L++     K H Q
Sbjct: 337 MRRQEEMMWEKEEKM--RRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEE-----KMHEQ 389

Query: 529 LAVFQRNELHSIFFTQIKSAIFKGELKPEAAKMLLQNYSKIQENVEELMDFFQASKRYHL 588
             + ++ E       Q +  I + E + E    + +   KI+E  E++ +  Q  K +  
Sbjct: 390 EKIREQEEKR-----QEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIRE--QEKKMWRQ 442

Query: 589 SKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTE 648
            ++   +E     ++  E R                 + +   +  E+++     R Q E
Sbjct: 443 EEKIHEQE----KIREEEKR-----------------QEQEEMWRQEEKI-----REQEE 476

Query: 649 VFSIKQKLDND---LKQEKKKLHQKLITKRRRELLQKHREQR-REQASVGEAFRTVEDAG 704
           ++  K+K+       KQE+K   Q+     + E +++  E+  R++  + E    + +  
Sbjct: 477 IWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQE 536

Query: 705 QYLHQKRSLMEEHGATLEELQERLDQAALDDLRTLTLSLFEKATDELRRLQNSAMTQELL 764
           + + ++  +M+E    + E +E++ +                  +++RR +     QE  
Sbjct: 537 EKIREQEEMMQEQEEKMGEQEEKMQEQ-----------------EKMRRQEEKIREQEEK 579

Query: 765 KRGVPWLFLQQILEEHGKEMAARAEQLEGEERDRDQEGVQSVRQRLKDDAPEAVTEEQAE 824
            R       ++I E+  K      +  E EE  ++QE     ++    +  E + E++ +
Sbjct: 580 IREQK----EKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEK 635

Query: 825 LRRWEHLIFMKLCSSVFSLSEEELLRMRQE 854
           +RR E  ++ +    V    +EE ++  QE
Sbjct: 636 MRRQEEKMWEQ---EVRLRQQEEKMQEHQE 662


>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
            sapiens]
          Length = 1983

 Score = 71.2 bits (173), Expect = 6e-12
 Identities = 158/726 (21%), Positives = 291/726 (40%), Gaps = 105/726 (14%)

Query: 444  QEEYDRKMVALTAECDLETRKKMENQYQREMMAMEEAEELLKRAGERSAVECSNLLRTLH 503
            ++E +   V++T E     +  +  Q Q E   + +AEE            C  L+++  
Sbjct: 919  RQELEETHVSITQE-----KNDLALQLQAEQDNLADAEE-----------RCHLLIKSKV 962

Query: 504  GLEQEHLRKSLALQQEEDF---AKAHRQLAVFQRNELHSIFFTQIKSAIFKGELKPEAAK 560
             LE +    S  L+ EE+      A R+    +  EL       +K  + K E + +A +
Sbjct: 963  QLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDI-DDLKLTLAKAEKEKQATE 1021

Query: 561  MLLQNYSKIQENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQL 620
              ++N ++    ++E +      K+   + +  H++ L  +LQ+ E RV  L + A  +L
Sbjct: 1022 NKVKNLTEEMAALDESVARLTKEKK---ALQEAHQQAL-GDLQAEEDRVSAL-TKAKLRL 1076

Query: 621  THLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLKQEKKKLHQKLITKRRRELL 680
               ++  E      E ++ M  ERA       K+KL+ DLK     L Q+ +    ++  
Sbjct: 1077 EQQVEDLE-CSLEQEKKLRMDTERA-------KRKLEGDLK-----LTQESVADAAQDKQ 1123

Query: 681  QKHREQRREQASVGEAFRTVEDAGQYLHQKRSLMEEHGATLEELQERLD-----QAALDD 735
            Q   + +++ + + +    VED      Q +  ++E  A  EEL+E L+     +A ++ 
Sbjct: 1124 QLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEK 1183

Query: 736  LRTLTLSLFEKATDELRRLQNSAMTQE--LLKRGVPWLFLQQILEE----HGKEMAA-RA 788
             R       E+ ++ L     ++  Q     KR      L++ LEE    H   +AA R 
Sbjct: 1184 QRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRR 1243

Query: 789  EQLEGEERDRDQ-EGVQSVRQRLKDDAPEAVTEEQAELRRWEHLIFMKLCSSVFSLSEEE 847
            +Q EG     +Q + +Q VRQ+L+ +  E   E        E L   K  +     + E+
Sbjct: 1244 KQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYED 1303

Query: 848  LLRMRQEVHGCFAQMDRSLA---LPKIRARVLLQQFQTAWREAEFV----KLDQAVAAPE 900
             L    E      ++ R LA     + R +    +      E E +       +A+AA  
Sbjct: 1304 QL---SEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQS 1360

Query: 901  LQQQSKVRKSRSKSKSKGELLKKCIEDKIHLCEEQASED---------LVEKVRGELLRE 951
            L++  +  +  SK+KS      + +     L  EQ  E+         L+ K   E+ + 
Sbjct: 1361 LEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQW 1420

Query: 952  R-------VQRMEAQEGGFAQSLVALQFQKASRVTETLSAYTALLSIQDLLLEELSASEM 1004
            R       +QR E  E   A+  +AL+ Q+A    E  +A  + L    L L+  S    
Sbjct: 1421 RSKYEADAIQRTEELEE--AKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVT 1478

Query: 1005 LTKSACTQILESHSRELQELERKLEDQLVQQEAAQQ-----------------------Q 1041
            L     T    +  ++ + LER LE++  Q+E  Q+                       +
Sbjct: 1479 LELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHE 1538

Query: 1042 QALASWQQWVADGPGILNEPGEVDSERQVSTVLHQALSKSQTLLEQHQ---QCLREEQQN 1098
            +AL + +    +   +  E  ++  +  +S    Q L K++  LE  +   Q   EE + 
Sbjct: 1539 EALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEG 1598

Query: 1099 SVVLED 1104
            ++ LE+
Sbjct: 1599 ALELEE 1604



 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 178/781 (22%), Positives = 313/781 (40%), Gaps = 87/781 (11%)

Query: 381  EELEIATLNRADADLEACRTQISKDIIALLLKNLTSSGHLSPQVERKMSAVFKKQFLLLE 440
            ++ E++ L+    D +    Q+ K I  L  +       L  + ER   A  +KQ     
Sbjct: 1132 KDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEEL--EAERAARARVEKQRAEAA 1189

Query: 441  NEIQEEYDRKMVALTAEC-DLETRKKMENQYQREMMAMEEAE-------ELLKRAGERSA 492
             E++E  +R   A  A     E  +K E +  R    +EEA          L+R     A
Sbjct: 1190 RELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGA 1249

Query: 493  VECSNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQL---AVFQRNELHSIFFTQIKSAI 549
             E    + +L  + Q+  ++   L+ E D   A+ +    A     +L   +  Q+  A 
Sbjct: 1250 AELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAK 1309

Query: 550  FK-GELKPEAAKMLLQNYSKIQENVEELMDFFQASKRYHLSKRFGHREYLVQNLQS---- 604
             K  EL+ + A    Q   ++Q    EL    +  K   +S+    +    Q+L+     
Sbjct: 1310 IKVEELQRQLADASTQR-GRLQTESGELSRLLE-EKECLISQLSRGKALAAQSLEELRRQ 1367

Query: 605  --SETRVQGLLSTAAAQLTH----LIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDN 658
               E++ +  L+ A   L H    L ++HE      + +++ LL +A  EV   + K + 
Sbjct: 1368 LEEESKAKSALAHAVQALRHDCDLLREQHEEEAEA-QAELQRLLSKANAEVAQWRSKYEA 1426

Query: 659  DLKQEKKKLHQKLITKRRRELLQKHREQRREQASVGEAFRTVEDAGQYLHQKRSLMEEHG 718
            D  Q  ++L +    K++  L  +  E+  E A+      ++E A      K  L  E  
Sbjct: 1427 DAIQRTEELEE---AKKKLALRLQEAEEGVEAANA--KCSSLEKA------KLRLQTESE 1475

Query: 719  ATLEELQERLDQAALDDLRTLTLSLFEKATDELRRLQNSAMTQEL--LKRGVPWLFLQQI 776
                EL+     AA  D +   L   E+A +E RR Q   M +EL   +R    L  +  
Sbjct: 1476 DVTLELERATSAAAALDKKQRHL---ERALEERRR-QEEEMQRELEAAQRESRGLGTELF 1531

Query: 777  LEEHGKEMAARAEQLEGEERDRDQEGVQSVRQRL----KDDAPEAVTEEQAELRRWEHLI 832
               HG E A  A +    E    QE +  +  ++    K       T++  E  + E   
Sbjct: 1532 RLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQA 1591

Query: 833  FMKLCSSVFSLSEEELLRMRQEVHGCFAQMDRSLALPKIRARVLLQQFQTAWREAEFVKL 892
             ++       L E + LR++ E+    A++DR LA        L +  Q A        +
Sbjct: 1592 ALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRA--------V 1643

Query: 893  DQAVAAPELQQQSKVRKSRSKSKSKGELLKKCIEDKIHLCEEQASE----------DLVE 942
            +   A+ + + +++    R K K +G+L    +E ++     QA+E           L E
Sbjct: 1644 ESLQASLDAETRARNEALRLKKKMEGDL--NDLELQLGHATRQATEAQAATRLMQAQLKE 1701

Query: 943  KVRGELLRERVQRMEAQEGGFAQSLVALQFQKASRVTETLSAYTALLSIQDLLLEELSAS 1002
            +  G   R+  QR+ A+    AQ+L     ++AS +   L    A L  Q      L+  
Sbjct: 1702 EQAG---RDEEQRLAAELHEQAQALE----RRASLLAAELEELRAALE-QGERSRRLAEQ 1753

Query: 1003 EMLTKSACTQILESHSRELQELERKLEDQLVQ-----QEAAQQ-QQALASWQQWVADGPG 1056
            E+L  +    +L S +  L   ++KLE  L Q     +EAAQ+ ++A    ++ + D   
Sbjct: 1754 ELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAM 1813

Query: 1057 ILNE-PGEVDSE---RQVSTVLHQALSKSQTLLEQHQQ-CLREEQQNSVVLEDLLENMEA 1111
            +  E   E D+     ++   L Q + + Q  LE+ +Q  LR  ++    LE  +  +EA
Sbjct: 1814 MAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEA 1873

Query: 1112 D 1112
            +
Sbjct: 1874 E 1874


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
            sapiens]
          Length = 750

 Score = 70.9 bits (172), Expect = 8e-12
 Identities = 133/658 (20%), Positives = 272/658 (41%), Gaps = 72/658 (10%)

Query: 415  TSSGHLSPQVERKMSAVFKKQFLLLENEIQEEYDRKMVALTAECDLETRKKMENQYQREM 474
            TS G  SP+ E+K S           ++ QE   R++ A      + T +K E Q     
Sbjct: 100  TSGGCHSPEDEQKAS-----------HQHQEALRRELEAQVHTIRILTCQKTELQ----- 143

Query: 475  MAMEEAEELLKRAGERSAVECSNLLRTLHGL-----EQEHLRKSLALQQEEDFAKAHRQL 529
            MA+  ++  +K+       E  +L+  LH       E E    ++A Q++    KA R +
Sbjct: 144  MALYYSQHAVKQLEG----EARDLISRLHDSWKFAGELEQALSAVATQKK----KADRYI 195

Query: 530  AVFQRNELHSIFFTQIKSAIFKGELKPEAAKM------LLQNYSKIQENVEELMDFFQAS 583
                + E  ++     ++ I   ELK + AK+      +    S+IQ NV+EL       
Sbjct: 196  EELTK-ERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKEL------- 247

Query: 584  KRYHLSKRFGHREYLV---QNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDEDQMEM 640
                  KR   R  L+   Q LQ+    +   L + +A+L   ++++E    L++ Q E 
Sbjct: 248  ------KRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEK 301

Query: 641  LL---ERAQTEVFSIKQKLDNDLKQEKKKLHQKLITKRRRELL-QKHREQRREQASVGEA 696
            +    E+ Q     I+++ +   +QE+K   Q+   +R+ E++ +K  + RR++  + E 
Sbjct: 302  MWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEK 361

Query: 697  FRTVEDAGQYLHQKRSLMEEHGATLEELQERLDQAALDDLRTLTLSLFEKATDELRRLQN 756
               +    + + +K   M      + E +E++ +          +   E+   E  +++ 
Sbjct: 362  EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIRE 421

Query: 757  SAMTQELLKRGVPWLFLQQILEEHGKEMAARAEQLEGEERDRDQEGVQSVRQRLKDDA-- 814
                QE  +    W   ++I E+  K      +    EE+  +QE ++   +R + +   
Sbjct: 422  QEKRQE--QEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMW 479

Query: 815  -PEAVTEEQAELRRWEHLIFMKLCSSVFSLSEEELLRMRQEVHGCFAQMDRSLALPKIRA 873
              E    EQ E+  W     M          EE++ R  +++     ++ R       R 
Sbjct: 480  RQEEKIHEQEEI--WRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKI-REQEEKMWRQ 536

Query: 874  RVLLQQFQTAWREAEFVKLDQAVAAPELQQQSKVRKSRSKSKSKGELLKKCIEDKIHLCE 933
               +++ +  WRE E +   + +   E +Q+ + +  R + K + +  K   +++    +
Sbjct: 537  EEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQ 596

Query: 934  EQASEDLVEKV--RGELLRERVQRMEAQEGGFAQSLVALQFQKASRVTETLSAYTALLSI 991
            E+  ++  EK+  + E +RE+ ++++ QE    +     Q +K     E        +  
Sbjct: 597  EEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIRE-----QEEKIREQEEMTQEQEEKMGE 651

Query: 992  QDLLLEELSASEMLTKSACTQILESHSRELQELERKLEDQLVQQEAAQQQQALASWQQ 1049
            Q+  + E    +M  +       E   RE ++  R+ E+++ +QE   Q+Q    W+Q
Sbjct: 652  QEEKMCE-QEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQ 708



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 76/411 (18%), Positives = 180/411 (43%), Gaps = 41/411 (9%)

Query: 423 QVERKMSAVFKKQFLLLENEIQEEYDRKMVALTAECDLETRKKMENQYQREMMA-MEEAE 481
           ++ R+   +++K+  + E E ++ ++++ +    E   E  K  E + ++E  A M   E
Sbjct: 378 KMRRQEEMMWEKEEKIRELE-EKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQE 436

Query: 482 ELLKRAGERSAVECSNLLRTLHGL-EQEHLRKSLALQQEEDFAKAHRQLAVFQRNELHSI 540
           E ++   E+   +   + R    + EQE +R+    Q++E+  +   ++     +E   I
Sbjct: 437 EKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKI-----HEQEEI 491

Query: 541 FFTQIKSAIFKGELKPEAAKMLLQNYSKIQENVEELMDFFQASKRYHLSKRFGHREYLVQ 600
           +  + K    + +++ +  K+  Q   KI+E  E++ +  Q  K +   ++   +E + +
Sbjct: 492 WRQKEKMHEQEEKIRKQEEKVWRQE-EKIREQEEKIRE--QEEKMWRQEEKIREQEEMWR 548

Query: 601 NLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDL 660
             +  +   Q  +     +     Q+ E   +  E+++    E+   +   I+++ +   
Sbjct: 549 --EEEKMHEQEKIWEEEKR-----QEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQ 601

Query: 661 KQEKKKLHQKLITKRRRELLQKHREQRREQASVGEAFRTVEDAGQYLHQKRSLMEEHGAT 720
           +QE+K   Q+   + + E +Q+  E+ REQ    E  R  E+  Q   +K    EE    
Sbjct: 602 EQEEKMWKQEEKIREQEEKIQEQEEKIREQE---EKIREQEEMTQEQEEKMGEQEEKMCE 658

Query: 721 LEELQERLDQAALDDLRTLTLSLFEKATDELRRLQNSAMTQELLKRGVPWLFLQQILEEH 780
            EE  +  ++               +  +++R  +     QE   R       +++++E 
Sbjct: 659 QEEKMQEQEET------------MWRQEEKIREQEKKIREQEEKIRE-----QEEMMQEQ 701

Query: 781 GKEMAARAEQL-EGEERDRDQEGVQSVRQRLKDDAPEAVTEEQAELRRWEH 830
            ++M  + E++ E EE+ ++QE  + +R++ +    + V   Q E +  EH
Sbjct: 702 EEKMWEQEEKMCEQEEKMQEQE--EKMRRQEEKMWEQEVRLRQQEEKMQEH 750


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 145/736 (19%), Positives = 328/736 (44%), Gaps = 118/736 (16%)

Query: 433  KKQFLLLENE---IQEEYDRKMVALTAECDLETRKKMENQYQREMMAMEEAEELLKRAGE 489
            K+Q  LL +E   +QE+ D ++  L    DL   +K +   Q     + +A+ L+++  +
Sbjct: 306  KEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQ-----LRDAKNLIEQLEQ 360

Query: 490  RSAVECSNLLRTLHGL----EQEHLRKSLALQQEEDFAKAHRQLAVFQRNELHSIFFTQI 545
               +  +   R +H      E+E  +    ++Q     +  R+    Q+ +     F ++
Sbjct: 361  DKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELRE----QKEKSERAAFEEL 416

Query: 546  KSAIFKGELKPEAAKMLLQNYSKIQENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSS 605
            + A+   +   EA + L     +  + +E+  +  + S +  LS+    +E +    +SS
Sbjct: 417  EKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRV--KQEVVDVMKKSS 474

Query: 606  ETRVQGL-------LSTAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDN 658
            E ++  L       L+    +LT  +Q  ER     ++QM++ LE++Q+E   I Q+   
Sbjct: 475  EEQIAKLQKLHEKELARKEQELTKKLQTREREF---QEQMKVALEKSQSEYLKISQE--- 528

Query: 659  DLKQEKKKLHQKLITKRRRELLQKHREQRREQASVGEAFRTVEDAGQYLHQKRSL---ME 715
              K++++ L  + +  +++ +L +   + R+     E +RT     + L  + SL   ++
Sbjct: 529  --KEQQESLALEELELQKKAILTESENKLRDLQQEAETYRT-----RILELESSLEKSLQ 581

Query: 716  EHGATLEELQERLDQAALDDLRTLTLSLFEKAT--DELRRLQNSAMTQELLKRGVPWLFL 773
            E+    ++L   L+       + +T+ + +  T  + L+  Q++  T++          L
Sbjct: 582  ENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEK----------L 631

Query: 774  QQILEEHGKEMAARAEQLEGEE----RDRD---QEGVQSVRQR------LKDDAPEAVTE 820
            Q + +++  EM    E+ E E+    +D++   Q  ++ + ++      +K    E+++ 
Sbjct: 632  QVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSS 691

Query: 821  EQAELRRWEHLIFMKLCSSVFSLSEEELLRMRQEVHGCFAQMDRSLALPKIRARVLLQQF 880
            E +E+ +  H +  +L     S+ +++  +M+QE+    A+MD      + +   ++++ 
Sbjct: 692  ELSEVLKARHKLEEEL-----SVLKDQTDKMKQELE---AKMDEQKNHHQQQVDSIIKEH 743

Query: 881  QTAWREAEFVKLDQAVAAPELQQQSKVRKSRSK----------------SKSKGELLKKC 924
            + + +  E    DQ      + Q   + K R K                 +S+GEL +  
Sbjct: 744  EVSIQRTEKALKDQ------INQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQAS 797

Query: 925  IEDKIHLCEEQASEDLVEKVRGEL--LRERVQRMEAQEGGFAQSLVALQFQKASRVTETL 982
             +  +    + A+ +  +    +L  L++++  +E +     + +  ++ QK    TE L
Sbjct: 798  AKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTE-L 856

Query: 983  SAYTALLSIQDLLLE-ELSASEMLTK-SACTQI----LESHSRELQELERKL---EDQLV 1033
             A+   + +QDL+ + E   SEM  K  + TQ+    LE  ++E ++ ++ L   E+ ++
Sbjct: 857  DAHK--IQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMIL 914

Query: 1034 QQEAAQQQQALASWQQWVA--DGPGILNEPGEV---DSERQVSTVLHQALSKSQTL---L 1085
            Q    Q+++     Q+  A  D   ILNE  E    + E+++  V  +A    +TL   L
Sbjct: 915  QMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKL 974

Query: 1086 EQHQQCLREEQQNSVV 1101
               +  L++E +N+ +
Sbjct: 975  LDQEAKLKKELENTAL 990



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 137/723 (18%), Positives = 291/723 (40%), Gaps = 105/723 (14%)

Query: 434  KQFLLLENEIQEE---YDRKMVALTAECDLETRK--KMENQYQREMMAMEEAEELLKRAG 488
            K+F  L+ E++++    ++K   L  E   +T +  ++E+   ++ + +E   E+LK   
Sbjct: 1493 KRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYN 1552

Query: 489  ERSAVECSNLLRTLHGLEQ----------EHLRKSLALQQEEDFAKA----------HRQ 528
            ++  +E   L++ L   ++          E   K L L+ +    KA          H  
Sbjct: 1553 QQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVN 1612

Query: 529  LAVFQRNELHSIFFTQIKS--AIFKGELKPEAAKMLLQNYSKIQENVEELMDFFQASKRY 586
            L+V  + E       +++S  A    ELK +A + +     ++   +EE  + ++     
Sbjct: 1613 LSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTES 1672

Query: 587  HLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDEDQMEM--LLER 644
            HLS+     +   + +   E +++ + S+ +  L         A Y ++++ +    +++
Sbjct: 1673 HLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQK 1732

Query: 645  AQTEVFSIKQKLDNDLKQEKKKLHQKLITKRRRELLQKHREQRREQASVGEAFRTVEDAG 704
               E  S+ Q+       EK+KL Q+ + + + E +  H E R +     E    +E A 
Sbjct: 1733 TYEEKISVLQRN----LTEKEKLLQR-VGQEKEETVSSHFEMRCQYQ---ERLIKLEHAE 1784

Query: 705  QYLHQKRSLMEEHGATLEELQERLDQAALDDLRTLTLSLFEKATDELRRLQN--SAMTQE 762
               H+ +S++   G   EEL+E+  + +L   + +     +      + L+N    + + 
Sbjct: 1785 AKQHEDQSMI---GHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKT 1841

Query: 763  LLKRGVPWLFLQQILEEHGKEMAARAE--QLEGEERDRDQEGVQSVRQRLKDDAPEAVTE 820
            L ++ +    L+Q ++E    +  + E  ++E EE     E +Q+++Q    + P  + E
Sbjct: 1842 LQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLE 1901

Query: 821  EQAELRRWEHLIFMKLCSSVFSLSEEELLRMRQEVHGCFAQMDRSLALPKIRARVLLQQF 880
            E  E +   HL+  KL S++ +   +                                +F
Sbjct: 1902 ENTEEKSKSHLVQPKLLSNMEAQHND-------------------------------LEF 1930

Query: 881  QTAWREAEFVKLDQAVAAPELQQQSKVRKSRSKSKSKGELLKKCIEDKIHLCEEQASEDL 940
            + A  E E  KL + +    ++ Q  +R  R + + + E+LKK  + +     +Q  EDL
Sbjct: 1931 KLAGAEREKQKLGKEI----VRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDL 1986

Query: 941  VEKVRGELLRERVQRMEAQEGGFAQSLVALQFQKASRVTETLSAYTALLSIQ----DLLL 996
             E      L++ ++    Q    AQ    L+      + +       LL       + LL
Sbjct: 1987 -ELKHNSTLKQLMREFNTQ---LAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLL 2042

Query: 997  EELSASE---MLTKSACTQILESHSRELQELERKLEDQLVQQEAAQQQQALASWQQWVAD 1053
            ++++  +     T     +IL++   E+    R L+ QL + +   QQ+           
Sbjct: 2043 KKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQK----------- 2091

Query: 1054 GPGILNEPGEVDSERQVSTVLHQALSKSQTLLEQHQQCLREEQQNSVVLEDLLENMEADT 1113
                L +     ++      L   L++  TL+   +   +E ++    LED L+  E + 
Sbjct: 2092 ----LEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEKNV 2147

Query: 1114 FAT 1116
            +AT
Sbjct: 2148 YAT 2150



 Score = 51.6 bits (122), Expect = 5e-06
 Identities = 131/644 (20%), Positives = 268/644 (41%), Gaps = 115/644 (17%)

Query: 555  KPEAAKMLLQNYSKIQENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLS 614
            K +   +L Q+  K    + EL +  Q  ++         +++L +   +S       +S
Sbjct: 171  KKKLQGILSQSQDKSLRRIAELREELQMDQQA--------KKHLQEEFDASLEEKDQYIS 222

Query: 615  TAAAQLTHLIQKHERAGYLDEDQMEMLLE-RAQTEVFSIKQKLDND-------------- 659
                Q++ L+++  R G ++ D ++ L +   Q EVF+ ++  ++D              
Sbjct: 223  VLQTQVS-LLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTL 281

Query: 660  --LKQEKKKLHQKLITKRRRELLQKHREQRREQASVGEAFRTVEDAGQYLHQKRSLMEEH 717
              L+Q  K+  Q+ + KR +E +Q H+EQ     S  EA +  E   + L +   + + H
Sbjct: 282  ETLQQRVKR--QENLLKRCKETIQSHKEQCTLLTSEKEALQ--EQLDERLQELEKIKDLH 337

Query: 718  GATLEELQERLDQA-----ALDDLRTLTLSLFEKATDELRRLQNSAMTQELLKRGVPWLF 772
             A   +L  +L  A      L+  + + ++  ++   E   ++   + Q  L+  +  + 
Sbjct: 338  MAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQ--LRSRIKQMT 395

Query: 773  LQQILEEHGKEMAARAEQLEGEERDRDQEGVQSVRQRLKDDAPEAV-------TEEQAEL 825
             Q       KE + RA   E E+     +  +  R++LK +  E +        EE+  L
Sbjct: 396  TQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISL 455

Query: 826  RRWEHLIFMKLCSSVFSLSEEELLRMRQEVHGCFAQMDRSLALP-KIRARVLLQQFQTAW 884
            ++    +  ++   +   SEE++ ++++      A+ ++ L    + R R   +Q + A 
Sbjct: 456  QQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVAL 515

Query: 885  R--EAEFVKLDQ------AVAAPELQQQSKVRKSRSKSKSK-----------------GE 919
               ++E++K+ Q      ++A  EL+ Q K   + S++K +                   
Sbjct: 516  EKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESS 575

Query: 920  LLKKCIEDK-------IHLCEEQASED-----LVEKVRGEL--LRER-----VQRMEAQE 960
            L K   E+K       +HL  E+   +     +VEK + EL  L+ +      ++++  +
Sbjct: 576  LEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLK 635

Query: 961  GGFAQSLVALQFQKASRVTETLSAYTALLSIQDLLLEELSASEMLTKSACTQILESHSRE 1020
              +   +  L+ +K  +  ETL     +  I    +EE++   +         LES S E
Sbjct: 636  QQYQTEMEKLR-EKCEQEKETLLKDKEI--IFQAHIEEMNEKTLEKLDVKQTELESLSSE 692

Query: 1021 LQEL---ERKLEDQL---------VQQEAAQQQQALASWQQWVADGPGILNEPGEVDSER 1068
            L E+     KLE++L         ++QE   +     +  Q   D   I+ E  EV  +R
Sbjct: 693  LSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVD--SIIKE-HEVSIQR 749

Query: 1069 QVSTVLHQALSKSQTLLEQHQQCLREEQQNSVVLEDLLENMEAD 1112
                 L   +++ + LL++  + L+E Q +       +EN+EAD
Sbjct: 750  -TEKALKDQINQLELLLKERDKHLKEHQAH-------VENLEAD 785



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 94/467 (20%), Positives = 186/467 (39%), Gaps = 45/467 (9%)

Query: 340  ESKLEPLPFTSADGVNEDLSLNDQMIDILSSEDPGSMLQALEELEIATLNRADADLEACR 399
            ES L  L     +   E   L +++  + SS+    ++    +   A   + +AD + C 
Sbjct: 1671 ESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCV 1730

Query: 400  TQISKDIIALLLKNLTSSGHLSPQVERKMSAVFKKQFLLLENEIQEEYDRKMVALT-AEC 458
             +  ++ I++L +NLT    L  +V ++        F     E++ +Y  +++ L  AE 
Sbjct: 1731 QKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHF-----EMRCQYQERLIKLEHAEA 1785

Query: 459  DLETRKKMENQYQREM------MAMEEAEELLKRAGERSAVECSNLLRTLHGLEQEHLRK 512
                 + M    Q E+       ++  A+ + K  G+ +     NL      +++    K
Sbjct: 1786 KQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEK 1845

Query: 513  SLALQQEEDFAKAHRQLAVFQRNELHSIFFTQIKSAIFKGELKPEAAKMLLQNYSKIQEN 572
             L  Q  E   K      V Q+ E+H +   ++ S   K +     A   +   +K  E 
Sbjct: 1846 ELTCQILEQKIKELDSCLVRQK-EVHRVEMEELTSKYEKLQ-----ALQQMDGRNKPTEL 1899

Query: 573  VEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHERAGY 632
            +EE  +  + SK + +  +      L+ N+++    ++  L+ A  +   L ++  R   
Sbjct: 1900 LEENTE--EKSKSHLVQPK------LLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRL-- 1949

Query: 633  LDEDQMEMLLERAQTEVFSIKQKLDNDLKQEKKKLHQKLITKRRRELLQKHREQRREQAS 692
              +  + ML +  Q E+  +K++ D + +++ K+  + L  K    L Q  RE   + A 
Sbjct: 1950 --QKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQ 2007

Query: 693  VGEAFRTV--EDAGQYLHQKRSLMEEHGATLEELQERLDQAALDDLRTLTLSLFEKATDE 750
              +       E   +    +  L+E H     +L +++  A  DD    T   +E+  D 
Sbjct: 2008 KEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKI--AEKDDDLKRTAKRYEEILD- 2064

Query: 751  LRRLQNSAMTQELLKRGVPWLFLQQILEEHGKEMAARAEQLEGEERD 797
             R  + +A  ++          LQ  LEE  K+   + EQ E    D
Sbjct: 2065 AREEEMTAKVRD----------LQTQLEELQKKYQQKLEQEENPGND 2101



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 130/676 (19%), Positives = 275/676 (40%), Gaps = 107/676 (15%)

Query: 456  AECDLETRKKMENQYQREMMAMEEAEELLKRAGERSAVECSNLLRTLHGLEQEHLRKSLA 515
            A   L+  +  ++    +  A EE  +L +   +   +E   +L T    E E  +K + 
Sbjct: 796  ASAKLDVFQSYQSATHEQTKAYEE--QLAQLQQKLLDLETERILLTKQVAEVEAQKKDVC 853

Query: 516  LQQEEDFAKAHRQLAVFQRNELHSIFFTQIKSAIFKGELKPEAAKMLLQNYSKIQENVEE 575
               E D  K   Q  + Q  + +S    ++KS     E K       L++ +K QE  ++
Sbjct: 854  T--ELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESK-------LEDGNKEQEQTKQ 904

Query: 576  LMDFFQASKRYHLSKRFGHR---EYLVQNLQSSETRVQGLLSTAAAQLTHLI-QKHERAG 631
            ++      +   L  R G +   E L Q L + E  +            H++ +++E   
Sbjct: 905  IL---VEKENMILQMREGQKKEIEILTQKLSAKEDSI------------HILNEEYETKF 949

Query: 632  YLDEDQMEMLLERAQTEVFSIKQKLDNDLKQEKKKLHQKLITKRRRELLQKHREQRREQA 691
               E +ME + ++A+    ++K+KL +   + KK+L    +     EL QK ++   +  
Sbjct: 950  KNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTAL-----ELSQKEKQFNAKML 1004

Query: 692  SVGEAFRT-VEDAGQYL-----HQKRSLMEEHGATLEEL----QERLDQAA--LDDLRTL 739
             + +A    + DA   L      Q  SL E H   L ++    +++L+Q A  L ++  +
Sbjct: 1005 EMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEI 1064

Query: 740  TLSLFEKATDELR-RLQNSAMTQELLKRGVPWLFLQQILEEHGKEMAARAEQLEGEERDR 798
             L   E+   EL+ ++      +E + + + WL          KE   + +    E +++
Sbjct: 1065 QLQEKEQEVAELKQKILLFGCEKEEMNKEITWL----------KEEGVKQDTTLNELQEQ 1114

Query: 799  DQEGVQSVRQRLKDDAPEAVTEEQAELRRWEHLIFMKLCSSVFSLSEEELLRMRQEVHGC 858
             ++    V    +D+     T+ +A L + E  +   L  + F   +E+L+ ++      
Sbjct: 1115 LKQKSAHVNSLAQDE-----TKLKAHLEKLEVDLNKSLKENTF--LQEQLVELKM----- 1162

Query: 859  FAQMDRSLALPKIRARVLLQQFQTAWREAEFVKLDQAVAAPELQQQSKVRKSRSKSKSKG 918
             A+ D      K +   L  + +T   E + +K             S   KS    + K 
Sbjct: 1163 LAEED------KRKVSELTSKLKTTDEEFQSLK-------------SSHEKSNKSLEDKS 1203

Query: 919  ELLKKCIED---KIHLCEEQASEDLVEKVRGELLRERVQRMEAQEGGFAQSLVALQFQKA 975
               KK  E+   ++ +C ++ +E L+E    EL+      + + +     S ++    + 
Sbjct: 1204 LEFKKLSEELAIQLDICCKK-TEALLEAKTNELI-----NISSSKTNAILSRISHCQHRT 1257

Query: 976  SRVTETLSAYTALLSIQDLLLEELSASE---MLTKSACTQILESHSRELQELERKLEDQL 1032
            ++V E L   T  +S  +  L +L+  +    ++    T  LE    +++ ++  +E  +
Sbjct: 1258 TKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLV 1317

Query: 1033 VQQEAAQQQQALASWQQWVADGPGILNE-PGEVDSERQVSTVLHQALSKSQ---TLLEQH 1088
             ++EA Q++    + QQ  ++    + +   E+       T++ + L + +   + L + 
Sbjct: 1318 TEKEALQKEG--GNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQ 1375

Query: 1089 QQCLREEQQNSVVLED 1104
               L  + QNS+ L +
Sbjct: 1376 LTDLNVQLQNSISLSE 1391


>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 168/839 (20%), Positives = 347/839 (41%), Gaps = 107/839 (12%)

Query: 357  DLSL-NDQMIDILSSEDPGSMLQALEELEIATLNRADADLEACRTQISKDIIALLLKNLT 415
            DL L  + ++DI + +         +E EI+ L     D +A   Q+ K I  L  +   
Sbjct: 1064 DLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEE 1123

Query: 416  SSGHLSPQVERKMSAVFKKQFLLLENEIQEEYDRKMVALTA-ECDLETRKKMENQYQREM 474
                +  + ER   A  +KQ   L  E++E  +R   A  A    +E  KK E ++Q+  
Sbjct: 1124 LEEEI--EAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMR 1181

Query: 475  MAMEEAE-------ELLKRAGERSAVECSNLLRTLHGLEQEHLRKSLALQQEEDFAKAHR 527
              +EEA          L++    S  E    +  L  ++Q+  ++   ++ E D   ++ 
Sbjct: 1182 RDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNV 1241

Query: 528  QLAVFQRNELHSIFFTQIKSAIFKGELKPEAAKMLLQNYSKIQENVEELMDFFQAS---K 584
            +     +  L  +  T ++  + + + K E  + L+ + +  +  ++     F      K
Sbjct: 1242 ETVSKAKGNLEKMCRT-LEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEK 1300

Query: 585  RYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQ--KHE----RAGYLDEDQ- 637
               +S+    ++   Q ++  + +++  +    A L H +Q  +H+    R  Y +E + 
Sbjct: 1301 EALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNA-LAHALQSSRHDCDLLREQYEEEQES 1359

Query: 638  ---MEMLLERAQTEVFSIKQKLDND-------LKQEKKKLHQKL------ITKRRRELLQ 681
               ++  L +A TEV   + K + D       L++ KKKL Q+L      +     +   
Sbjct: 1360 KAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCAS 1419

Query: 682  KHREQRREQASVGEAFRTVED---AGQYLHQKR----SLMEEHGATLEELQERLDQAALD 734
              + ++R Q  V +    VE    A   L +K+     ++ E     EE    L+ A+  
Sbjct: 1420 LEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELE-ASQK 1478

Query: 735  DLRTLTLSLF------EKATDELRRLQN---------SAMTQELLKRGVPWLFLQQILEE 779
            + R+L   LF      E++ D+L  L+          S +T+++ + G     L++I ++
Sbjct: 1479 EARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQ 1538

Query: 780  HGKEMAARAEQLEGEERDRDQEGVQSVRQRL-----KDDAPEAVTEEQAELRRWE--HLI 832
              +E       LE  E   + E  + +R +L     K +    + E+  E+ + +  H+ 
Sbjct: 1539 VEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIR 1598

Query: 833  FMKLCSSVFSL---SEEELLRMRQEVHGCFAQMDRSLALPKIRARVLLQQFQTAWREAEF 889
             ++   S       S  + +R+++++ G   +M+  L      A   L+ ++        
Sbjct: 1599 IVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNT---QGI 1655

Query: 890  VKLDQAVAAPELQQQSKVRKSRSKSKSKGELLKKCIED-KIHLCEEQASEDLVEKVRGEL 948
            +K  Q      L+ Q  +++  +  + +  LL+  IE+ +  L + + S  + E+   EL
Sbjct: 1656 LKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQ---EL 1712

Query: 949  L--RERVQRMEAQEGGFAQSLVALQFQKASRVTETLSAYTALLSIQDLLLEELSASEMLT 1006
            L   ERVQ +  Q      +   L+   +    E          ++D+L E  +A E   
Sbjct: 1713 LDASERVQLLHTQNTSLINTKKKLETDISQMQGE----------MEDILQEARNAEEKAK 1762

Query: 1007 KSACTQIL--------ESHSRELQELERKLED-----QLVQQEAAQQQQALASWQQWVAD 1053
            K+     +        +  S  L+ +++ +E      QL   EA  +Q AL   ++ +  
Sbjct: 1763 KAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEA--EQLALKGGKKQIQK 1820

Query: 1054 GPGILNE-PGEVDSERQVSTVLHQALSKSQTLLEQHQQCLREEQQNSVVLEDLLENMEA 1111
                + E  GEV+SE++ +    + L K +  +++      E+++N + L+DL++ ++A
Sbjct: 1821 LEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQA 1879



 Score = 64.7 bits (156), Expect = 6e-10
 Identities = 124/583 (21%), Positives = 247/583 (42%), Gaps = 82/583 (14%)

Query: 542  FTQIKSAIFKGELKPEAAKMLLQNYSKIQENV--EELMDFFQASKRYHLSKRFGHREYLV 599
            F +IK  +   E + E A M  + + KI++ +   E        K   L K     +  V
Sbjct: 839  FFKIKPLLKSAETEKEMATMK-EEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQV 897

Query: 600  Q----NLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQK 655
            Q     L  +E R   L+ T       + +  ERA    ED+ E+       E+ + K+K
Sbjct: 898  QAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERA----EDEEEI-----NAELTAKKRK 948

Query: 656  LDNDLKQEKKKLHQKLITKRRRELLQKHREQRREQASVGEAFRTVEDAGQYLHQKRSLME 715
            L+++  + KK +    +T  + E  +KH  + + +    E     E   +   +K++L E
Sbjct: 949  LEDECSELKKDIDDLELTLAKVEK-EKHATENKVKNLTEEMAGLDETIAKLTKEKKALQE 1007

Query: 716  EHGATLEELQERLDQAALDDLRTLTLSLFEKATD---ELRRLQNSAMTQELLKRGVPWLF 772
             H  TL++LQ   D+  ++ L    + L ++  D    L + +   M  E  KR +    
Sbjct: 1008 AHQQTLDDLQAEEDK--VNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDL 1065

Query: 773  LQQILEEHGKEMAARAEQLEGEERDRDQEGVQSVRQRLKDD------APEAVTEEQAELR 826
              ++ +E   ++    +QL+ + + ++ E + +++ +++D+        + + E QA + 
Sbjct: 1066 --KLAQESIMDIENEKQQLDEKLKKKEFE-ISNLQSKIEDEQALGIQLQKKIKELQARIE 1122

Query: 827  RWEHLIFMKLCSSVFSLSE-EELLRMRQEVHGCFAQMDRSLALPKIRARVLLQQFQTAWR 885
              E  I  +  S   +  +  +L R  +E+         S  L +       Q      R
Sbjct: 1123 ELEEEIEAERASRAKAEKQRSDLSRELEEI---------SERLEEAGGATSAQIEMNKKR 1173

Query: 886  EAEFVKLDQAVAAPELQQQSKVRKSRSK---------------SKSKGELLKKCIEDKIH 930
            EAEF K+ + +    LQ ++     R K                + K +L K+  E K+ 
Sbjct: 1174 EAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKME 1233

Query: 931  LCEEQASEDLVEKVRGEL------LRERVQRMEAQEGGFAQSLVALQFQKASRVTETLSA 984
            + +  ++ + V K +G L      L +++  ++++E    + +  L  Q+    TE+   
Sbjct: 1234 IDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTES-GE 1292

Query: 985  YTALLSIQDLLLEELSASEMLTKSACTQILESHSRELQELERKLEDQLVQQEAAQQQQAL 1044
            ++  L  ++ L+ +LS      K A TQ       +++EL+R+LE+++      + + AL
Sbjct: 1293 FSRQLDEKEALVSQLSRG----KQAFTQ-------QIEELKRQLEEEI------KAKNAL 1335

Query: 1045 ASWQQWVADGPGILNEPGEVDSERQVSTVLHQALSKSQTLLEQ 1087
            A   Q       +L E  + + E++    L +ALSK+ T + Q
Sbjct: 1336 AHALQSSRHDCDLLRE--QYEEEQESKAELQRALSKANTEVAQ 1376



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 92/466 (19%), Positives = 186/466 (39%), Gaps = 73/466 (15%)

Query: 339  YESKLEPLPFTSADGVNEDLSLNDQMIDILSSEDPGSMLQALEELEI----------ATL 388
            YE  L+ L     +  N    ++D    I      G  +  LE+++           A L
Sbjct: 1494 YEESLDQLETLKRENKNLQQEISDLTEQIAEG---GKRIHELEKIKKQVEQEKCELQAAL 1550

Query: 389  NRADADLEACRTQISKDIIALLLKNLTSSGHLSPQVERKMSAVFKKQFLLLENEIQEEYD 448
              A+A LE    +I +  I L L  + S      +V+RK++   ++   L  N I     
Sbjct: 1551 EEAEASLEHEEGKILR--IQLELNQVKS------EVDRKIAEKDEEIDQLKRNHI----- 1597

Query: 449  RKMVALTAECDLETRKKMENQYQREMMA--MEEAEELLKRAGERSAVECSNLLRTLHGLE 506
            R + ++ +  D E R + +    ++ M   + E E  L  A   +A    N   T   L+
Sbjct: 1598 RIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILK 1657

Query: 507  QEHLRKSLALQQEEDFAKAHRQLAVFQRN-ELHSIFFTQIKSAIFKGELKPEAAKM-LLQ 564
               +    AL+ +ED  +   QLA+ +R   L      ++++ + + E   + A+  LL 
Sbjct: 1658 DTQIHLDDALRSQEDLKE---QLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLD 1714

Query: 565  NYSKIQENVEELMDFFQASKRYH--LSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTH 622
               ++Q    +        K+    +S+  G  E ++Q  +++E + +  ++ AA     
Sbjct: 1715 ASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEE 1774

Query: 623  LIQKHERAGYLD--EDQMEMLLERAQTEVFSIKQ------------------KLDNDLKQ 662
            L ++ + + +L+  +  ME  ++  Q  +   +Q                  +L+ +++ 
Sbjct: 1775 LKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVES 1834

Query: 663  EKKKLHQKLITKRR-----RELLQKHREQRRE-----------QASVGEAFRTVEDAGQY 706
            E+K+  + +   R+     +EL  +  E R+            QA V    R  E+A + 
Sbjct: 1835 EQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQ 1894

Query: 707  LHQKRSLMEEHGATLEELQERLD--QAALDDLRTLTLSLFEKATDE 750
             +   +   +    LEE +ER D  ++ ++ LR  +  +  K   E
Sbjct: 1895 SNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKVISE 1940


>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 168/839 (20%), Positives = 347/839 (41%), Gaps = 107/839 (12%)

Query: 357  DLSL-NDQMIDILSSEDPGSMLQALEELEIATLNRADADLEACRTQISKDIIALLLKNLT 415
            DL L  + ++DI + +         +E EI+ L     D +A   Q+ K I  L  +   
Sbjct: 1064 DLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEE 1123

Query: 416  SSGHLSPQVERKMSAVFKKQFLLLENEIQEEYDRKMVALTA-ECDLETRKKMENQYQREM 474
                +  + ER   A  +KQ   L  E++E  +R   A  A    +E  KK E ++Q+  
Sbjct: 1124 LEEEI--EAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMR 1181

Query: 475  MAMEEAE-------ELLKRAGERSAVECSNLLRTLHGLEQEHLRKSLALQQEEDFAKAHR 527
              +EEA          L++    S  E    +  L  ++Q+  ++   ++ E D   ++ 
Sbjct: 1182 RDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNV 1241

Query: 528  QLAVFQRNELHSIFFTQIKSAIFKGELKPEAAKMLLQNYSKIQENVEELMDFFQAS---K 584
            +     +  L  +  T ++  + + + K E  + L+ + +  +  ++     F      K
Sbjct: 1242 ETVSKAKGNLEKMCRT-LEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEK 1300

Query: 585  RYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQ--KHE----RAGYLDEDQ- 637
               +S+    ++   Q ++  + +++  +    A L H +Q  +H+    R  Y +E + 
Sbjct: 1301 EALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNA-LAHALQSSRHDCDLLREQYEEEQES 1359

Query: 638  ---MEMLLERAQTEVFSIKQKLDND-------LKQEKKKLHQKL------ITKRRRELLQ 681
               ++  L +A TEV   + K + D       L++ KKKL Q+L      +     +   
Sbjct: 1360 KAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCAS 1419

Query: 682  KHREQRREQASVGEAFRTVED---AGQYLHQKR----SLMEEHGATLEELQERLDQAALD 734
              + ++R Q  V +    VE    A   L +K+     ++ E     EE    L+ A+  
Sbjct: 1420 LEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELE-ASQK 1478

Query: 735  DLRTLTLSLF------EKATDELRRLQN---------SAMTQELLKRGVPWLFLQQILEE 779
            + R+L   LF      E++ D+L  L+          S +T+++ + G     L++I ++
Sbjct: 1479 EARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQ 1538

Query: 780  HGKEMAARAEQLEGEERDRDQEGVQSVRQRL-----KDDAPEAVTEEQAELRRWE--HLI 832
              +E       LE  E   + E  + +R +L     K +    + E+  E+ + +  H+ 
Sbjct: 1539 VEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIR 1598

Query: 833  FMKLCSSVFSL---SEEELLRMRQEVHGCFAQMDRSLALPKIRARVLLQQFQTAWREAEF 889
             ++   S       S  + +R+++++ G   +M+  L      A   L+ ++        
Sbjct: 1599 IVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNT---QGI 1655

Query: 890  VKLDQAVAAPELQQQSKVRKSRSKSKSKGELLKKCIED-KIHLCEEQASEDLVEKVRGEL 948
            +K  Q      L+ Q  +++  +  + +  LL+  IE+ +  L + + S  + E+   EL
Sbjct: 1656 LKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQ---EL 1712

Query: 949  L--RERVQRMEAQEGGFAQSLVALQFQKASRVTETLSAYTALLSIQDLLLEELSASEMLT 1006
            L   ERVQ +  Q      +   L+   +    E          ++D+L E  +A E   
Sbjct: 1713 LDASERVQLLHTQNTSLINTKKKLETDISQMQGE----------MEDILQEARNAEEKAK 1762

Query: 1007 KSACTQIL--------ESHSRELQELERKLED-----QLVQQEAAQQQQALASWQQWVAD 1053
            K+     +        +  S  L+ +++ +E      QL   EA  +Q AL   ++ +  
Sbjct: 1763 KAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEA--EQLALKGGKKQIQK 1820

Query: 1054 GPGILNE-PGEVDSERQVSTVLHQALSKSQTLLEQHQQCLREEQQNSVVLEDLLENMEA 1111
                + E  GEV+SE++ +    + L K +  +++      E+++N + L+DL++ ++A
Sbjct: 1821 LEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQA 1879



 Score = 64.7 bits (156), Expect = 6e-10
 Identities = 124/583 (21%), Positives = 247/583 (42%), Gaps = 82/583 (14%)

Query: 542  FTQIKSAIFKGELKPEAAKMLLQNYSKIQENV--EELMDFFQASKRYHLSKRFGHREYLV 599
            F +IK  +   E + E A M  + + KI++ +   E        K   L K     +  V
Sbjct: 839  FFKIKPLLKSAETEKEMATMK-EEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQV 897

Query: 600  Q----NLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQK 655
            Q     L  +E R   L+ T       + +  ERA    ED+ E+       E+ + K+K
Sbjct: 898  QAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERA----EDEEEI-----NAELTAKKRK 948

Query: 656  LDNDLKQEKKKLHQKLITKRRRELLQKHREQRREQASVGEAFRTVEDAGQYLHQKRSLME 715
            L+++  + KK +    +T  + E  +KH  + + +    E     E   +   +K++L E
Sbjct: 949  LEDECSELKKDIDDLELTLAKVEK-EKHATENKVKNLTEEMAGLDETIAKLTKEKKALQE 1007

Query: 716  EHGATLEELQERLDQAALDDLRTLTLSLFEKATD---ELRRLQNSAMTQELLKRGVPWLF 772
             H  TL++LQ   D+  ++ L    + L ++  D    L + +   M  E  KR +    
Sbjct: 1008 AHQQTLDDLQAEEDK--VNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDL 1065

Query: 773  LQQILEEHGKEMAARAEQLEGEERDRDQEGVQSVRQRLKDD------APEAVTEEQAELR 826
              ++ +E   ++    +QL+ + + ++ E + +++ +++D+        + + E QA + 
Sbjct: 1066 --KLAQESIMDIENEKQQLDEKLKKKEFE-ISNLQSKIEDEQALGIQLQKKIKELQARIE 1122

Query: 827  RWEHLIFMKLCSSVFSLSE-EELLRMRQEVHGCFAQMDRSLALPKIRARVLLQQFQTAWR 885
              E  I  +  S   +  +  +L R  +E+         S  L +       Q      R
Sbjct: 1123 ELEEEIEAERASRAKAEKQRSDLSRELEEI---------SERLEEAGGATSAQIEMNKKR 1173

Query: 886  EAEFVKLDQAVAAPELQQQSKVRKSRSK---------------SKSKGELLKKCIEDKIH 930
            EAEF K+ + +    LQ ++     R K                + K +L K+  E K+ 
Sbjct: 1174 EAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKME 1233

Query: 931  LCEEQASEDLVEKVRGEL------LRERVQRMEAQEGGFAQSLVALQFQKASRVTETLSA 984
            + +  ++ + V K +G L      L +++  ++++E    + +  L  Q+    TE+   
Sbjct: 1234 IDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTES-GE 1292

Query: 985  YTALLSIQDLLLEELSASEMLTKSACTQILESHSRELQELERKLEDQLVQQEAAQQQQAL 1044
            ++  L  ++ L+ +LS      K A TQ       +++EL+R+LE+++      + + AL
Sbjct: 1293 FSRQLDEKEALVSQLSRG----KQAFTQ-------QIEELKRQLEEEI------KAKNAL 1335

Query: 1045 ASWQQWVADGPGILNEPGEVDSERQVSTVLHQALSKSQTLLEQ 1087
            A   Q       +L E  + + E++    L +ALSK+ T + Q
Sbjct: 1336 AHALQSSRHDCDLLRE--QYEEEQESKAELQRALSKANTEVAQ 1376



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 92/466 (19%), Positives = 186/466 (39%), Gaps = 73/466 (15%)

Query: 339  YESKLEPLPFTSADGVNEDLSLNDQMIDILSSEDPGSMLQALEELEI----------ATL 388
            YE  L+ L     +  N    ++D    I      G  +  LE+++           A L
Sbjct: 1494 YEESLDQLETLKRENKNLQQEISDLTEQIAEG---GKRIHELEKIKKQVEQEKCELQAAL 1550

Query: 389  NRADADLEACRTQISKDIIALLLKNLTSSGHLSPQVERKMSAVFKKQFLLLENEIQEEYD 448
              A+A LE    +I +  I L L  + S      +V+RK++   ++   L  N I     
Sbjct: 1551 EEAEASLEHEEGKILR--IQLELNQVKS------EVDRKIAEKDEEIDQLKRNHI----- 1597

Query: 449  RKMVALTAECDLETRKKMENQYQREMMA--MEEAEELLKRAGERSAVECSNLLRTLHGLE 506
            R + ++ +  D E R + +    ++ M   + E E  L  A   +A    N   T   L+
Sbjct: 1598 RIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILK 1657

Query: 507  QEHLRKSLALQQEEDFAKAHRQLAVFQRN-ELHSIFFTQIKSAIFKGELKPEAAKM-LLQ 564
               +    AL+ +ED  +   QLA+ +R   L      ++++ + + E   + A+  LL 
Sbjct: 1658 DTQIHLDDALRSQEDLKE---QLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLD 1714

Query: 565  NYSKIQENVEELMDFFQASKRYH--LSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTH 622
               ++Q    +        K+    +S+  G  E ++Q  +++E + +  ++ AA     
Sbjct: 1715 ASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEE 1774

Query: 623  LIQKHERAGYLD--EDQMEMLLERAQTEVFSIKQ------------------KLDNDLKQ 662
            L ++ + + +L+  +  ME  ++  Q  +   +Q                  +L+ +++ 
Sbjct: 1775 LKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVES 1834

Query: 663  EKKKLHQKLITKRR-----RELLQKHREQRRE-----------QASVGEAFRTVEDAGQY 706
            E+K+  + +   R+     +EL  +  E R+            QA V    R  E+A + 
Sbjct: 1835 EQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQ 1894

Query: 707  LHQKRSLMEEHGATLEELQERLD--QAALDDLRTLTLSLFEKATDE 750
             +   +   +    LEE +ER D  ++ ++ LR  +  +  K   E
Sbjct: 1895 SNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKVISE 1940


>gi|156104908 myosin heavy chain 6 [Homo sapiens]
          Length = 1939

 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 150/732 (20%), Positives = 297/732 (40%), Gaps = 100/732 (13%)

Query: 421  SPQVERKMSAVFKKQFLLLENEIQE------EYDRKMVALTAECDLETRKKMENQYQREM 474
            S + E++M A  K++F  ++  +++      E + KMV+L     L+ +  ++ Q Q E 
Sbjct: 844  SAETEKEM-ATMKEEFGRIKETLEKSEARRKELEEKMVSL-----LQEKNDLQLQVQAEQ 897

Query: 475  MAMEEAEELLKRAGERSAVECSNLLRTLHGLEQEHLRKSLALQQEEDF---AKAHRQLAV 531
              + +AEE            C  L++    LE +    +  L+ EE+      A ++   
Sbjct: 898  DNLNDAEE-----------RCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLE 946

Query: 532  FQRNELHSIFFTQIKSAIFKGELKPEAAKMLLQNYSKIQENVEELMDFFQASKRYHLSKR 591
             + +EL       ++  + K E +  A +  ++N ++    ++E++      K+   + +
Sbjct: 947  DECSELKKDI-DDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKK---ALQ 1002

Query: 592  FGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDEDQ-MEMLLERAQTEVF 650
              H++ L  +LQ  E +V  L S +  +L   +   E  G L++++ + M LERA     
Sbjct: 1003 EAHQQAL-DDLQVEEDKVNSL-SKSKVKLEQQVDDLE--GSLEQEKKVRMDLERA----- 1053

Query: 651  SIKQKLDNDLKQEKKKLHQKLITKRRRELLQKHREQRREQASVGEAFRTVEDAGQYLHQK 710
              K+KL+ DLK     L Q+ I     + LQ   + ++++  + +    +ED      Q 
Sbjct: 1054 --KRKLEGDLK-----LTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQL 1106

Query: 711  RSLMEEHGATLEELQERLD-----QAALDDLRTLTLSLFEKATDELRRLQNSAMTQELL- 764
            +  ++E+ A +EEL+E L+     +A ++ LR+      E+ ++ L     +   Q  + 
Sbjct: 1107 QKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMN 1166

Query: 765  -KRGVPWLFLQQILEEHGKEMAARAEQLEGEERDRDQE------GVQSVRQRLKDDAPEA 817
             KR   +  +++ LEE   +  A A  L  +  D   E       +Q V+Q+L+ +  E 
Sbjct: 1167 KKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEF 1226

Query: 818  VTEEQAELRRWEHLIFMKLCSSVFSLSEEELLRMRQEVHGCFAQMDRSL-ALPKIRARVL 876
              E        E +I  K      S + E+      E      +  RSL      RA++ 
Sbjct: 1227 KLELDDVTSNMEQIIKAKANLEKVSRTLED---QANEYRVKLEEAQRSLNDFTTQRAKLQ 1283

Query: 877  LQQFQTA----WREAEFVKLDQAVAAPELQQQSKVRKSRSKSKSKGELLKKCIEDKIHLC 932
             +  + A     +EA   +L +   +   Q +   R+   + K+K   L   ++   H C
Sbjct: 1284 TENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAK-NALAHALQSARHDC 1342

Query: 933  E---EQASEDLVEKVRGELLRERVQRMEAQEGGFAQSLVALQFQKASRVTETLSAYTALL 989
            +   EQ  E+   K     L+  + +  ++   +         Q+   + E        L
Sbjct: 1343 DLLREQYEEETEAKAE---LQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1399

Query: 990  SIQDLLLEELSASEMLTKSACTQILESHSRELQELERKLEDQLVQQEAAQQQQA------ 1043
               +  +E ++A        C+ + ++  R    L+ ++ED +V  E +    A      
Sbjct: 1400 QDAEEAVEAVNAK-------CSSLEKTKHR----LQNEIEDLMVDVERSNAAAAALDKKQ 1448

Query: 1044 ------LASWQQWVADGPGILNEPGEVDSERQVSTVLHQALSKSQTLLEQHQQCLREEQQ 1097
                  LA W+Q   +    L    +    R +ST L +  +  +  LE  +   RE + 
Sbjct: 1449 RNFDKILAEWKQKYEESQSELESSQK--EARSLSTELFKLKNAYEESLEHLETFKRENKN 1506

Query: 1098 NSVVLEDLLENM 1109
                + DL E +
Sbjct: 1507 LQEEISDLTEQL 1518



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 160/815 (19%), Positives = 348/815 (42%), Gaps = 110/815 (13%)

Query: 381  EELEIATLNRADADLEACRTQISKDIIALLLKNLTSSGHLSPQVERKMSAVFKKQFLL-- 438
            +E +I   N    D +    Q+ K     L +N      L  ++E + +A  K + L   
Sbjct: 1085 KEFDINQQNSKIEDEQVLALQLQKK----LKENQARIEELEEELEAERTARAKVEKLRSD 1140

Query: 439  LENEIQEEYDRKMVALTA-ECDLETRKKMENQYQREMMAMEEAE-------ELLKRAGER 490
            L  E++E  +R   A  A    +E  KK E ++Q+    +EEA          L++    
Sbjct: 1141 LSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHAD 1200

Query: 491  SAVECSNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVFQRNELHSIFFTQIKSAIF 550
            S  E    +  L  ++Q+  ++    + E D   ++ +  +  +  L  +  T ++    
Sbjct: 1201 SVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRT-LEDQAN 1259

Query: 551  KGELKPEAAKMLLQNYSKIQENVEELMDFFQASKRYHLSKRFGHREYLVQNL-------- 602
            +  +K E A+  L +++  +  ++        ++   L+++   +E L+  L        
Sbjct: 1260 EYRVKLEEAQRSLNDFTTQRAKLQ--------TENGELARQLEEKEALISQLTRGKLSYT 1311

Query: 603  QSSETRVQGLLSTAAAQ--LTHLIQ--KHE----RAGYLDEDQ----MEMLLERAQTEVF 650
            Q  E   + L     A+  L H +Q  +H+    R  Y +E +    ++ +L +A +EV 
Sbjct: 1312 QQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVA 1371

Query: 651  SIKQKLDND-------LKQEKKKLHQKL---------ITKRRRELLQ-KHREQRREQASV 693
              + K + D       L++ KKKL Q+L         +  +   L + KHR Q   +  +
Sbjct: 1372 QWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLM 1431

Query: 694  GEAFRTVEDAGQYLHQKRS---LMEEHGATLEELQERLDQAALDDLRTLTLSLF------ 744
             +  R+   A     ++R+   ++ E     EE Q  L+ +   + R+L+  LF      
Sbjct: 1432 VDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQ-KEARSLSTELFKLKNAY 1490

Query: 745  -------EKATDELRRLQN--SAMTQELLKRGVPWLFLQQILEEHGKEMAARAEQLEGEE 795
                   E    E + LQ   S +T++L + G     L+++ ++   E       LE  E
Sbjct: 1491 EESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAE 1550

Query: 796  RDRDQEGVQSVRQRLKDDAPEAVTE----------EQAELRRWEHLIFMKLCSSVFSLSE 845
               + E  + +R +L+ +  +A  E          EQA+      +  ++      + S 
Sbjct: 1551 ASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSR 1610

Query: 846  EELLRMRQEVHGCFAQMDRSLALPK---IRARVLLQQFQTAWREAEFVKLDQAVAAPELQ 902
             E+LR+++++ G   +M+  L+        A+  ++  Q+  ++ + ++LD AV A +  
Sbjct: 1611 NEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQ-IQLDDAVRANDDL 1669

Query: 903  QQSKVRKSRSKSKSKGELLK-KCIEDKIHLCEEQASEDLVE-KVRGELLRERVQRMEAQE 960
            +++     R  +  + EL + + + ++     + A ++L+E   R +LL  +   +  Q+
Sbjct: 1670 KENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQK 1729

Query: 961  GGFAQSLVALQFQKASRVTETLSAYT-ALLSIQD--LLLEELSASEMLTKSACTQILESH 1017
                  L  LQ +    V E  +A   A  +I D  ++ EEL   E  T +   ++ ++ 
Sbjct: 1730 KKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELK-KEQDTSAHLERMKKNM 1788

Query: 1018 SRELQELERKLED--QLVQQEAAQQQQALASWQQWVADGPGILNEPGEVDSERQVSTVLH 1075
             + +++L+ +L++  Q+  +   +Q Q L +          +    GE+++E++ +    
Sbjct: 1789 EQTIKDLQHRLDEAEQIALKGGKKQLQKLEA---------RVRELEGELEAEQKRNAESV 1839

Query: 1076 QALSKSQTLLEQHQQCLREEQQNSVVLEDLLENME 1110
            + + KS+  +++      E+++N + L+DL++ ++
Sbjct: 1840 KGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQ 1874



 Score = 37.0 bits (84), Expect = 0.12
 Identities = 79/415 (19%), Positives = 165/415 (39%), Gaps = 48/415 (11%)

Query: 844  SEEELLRMRQEVHGCFAQMDRSLALPKIRARVLLQQFQTAWREAEFVKLDQAVAAPELQQ 903
            +E+E+  M++E    F ++  +L   + R + L ++  +  +E   ++L        L  
Sbjct: 847  TEKEMATMKEE----FGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLND 902

Query: 904  QSKVRKSRSKSKSKGELLKKCIEDKIHLCEEQASEDLVEKVRGELLRERVQRMEAQEGGF 963
              +      K+K + E   K + +++   EE+ + +L  K R   L +    ++      
Sbjct: 903  AEERCDQLIKNKIQLEAKVKEMNERLE-DEEEMNAELTAKKRK--LEDECSELKKDIDDL 959

Query: 964  AQSLVALQFQKASRVTETLSAYTALLSIQDL---LLEELSASEMLTKSACT--QILESHS 1018
              +L  ++ +K +   +  +    +  + ++   L +E  A +   + A    Q+ E   
Sbjct: 960  ELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKV 1019

Query: 1019 RELQELERKLEDQLVQQEAAQQQQALASWQQWVA----DGPGILNEPGEVDSERQVSTVL 1074
              L + + KLE Q+   E + +Q+         A    +G   L +   +D E      L
Sbjct: 1020 NSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLEND-KLQL 1078

Query: 1075 HQALSKSQTLLEQHQQCLREEQ-----------QNSVVLEDLLENMEADTFATLCSQELR 1123
             + L K +  + Q    + +EQ           +N   +E+L E +EA+  A    ++LR
Sbjct: 1079 EEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLR 1138

Query: 1124 ------LASYLARMAMVPGATLRRLLSVVLPTASQPQLLALLDSAT-----------ERH 1166
                  L     R+    GAT  ++       A   ++   L+ AT           ++H
Sbjct: 1139 SDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKH 1198

Query: 1167 VDHAAESDGGAEQADVGRRRKHQSWWQALDGKLRGDLISRGLEKMLWARKRKQSI 1221
             D  AE     EQ D  +R K +   +  + KL  D ++  +E+++ A+   + +
Sbjct: 1199 ADSVAEL---GEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKV 1250


>gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens]
          Length = 1140

 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 167/753 (22%), Positives = 321/753 (42%), Gaps = 110/753 (14%)

Query: 401  QISKDIIALLLKNLTSSGHLSPQVE------RKMSAVFKKQFLLLENEIQEEYDRKMVAL 454
            Q++K I AL  KN      +    +      +++ A  +++ L  ++++ EE D +    
Sbjct: 50   QLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETREKILQYKSKVTEELDLRRKIQ 109

Query: 455  TAECDLETRKKMENQYQREMMAMEEAEELLKRAGERSAVE----CSNLLRTLHGLEQEHL 510
              E  LE   KM+ Q   E  A +   E ++   E   V+     S  +  +    +E L
Sbjct: 110  VLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKL 169

Query: 511  RK--SLALQQEEDFAKAHRQLAVFQRNELHSIFFTQI--KSAIFKGELKPEAA-KMLLQN 565
            R    L +Q E+D   A   L    R E+  +  +Q    +++ KG+ K E   +M +++
Sbjct: 170  RSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVES 229

Query: 566  YSKIQENV----EELMDFFQASKRYHLSKRFGHRE---------YLVQNLQSSETRVQGL 612
             +K+ E +    ++L++ ++   + + ++ F  RE         +  ++LQ+S+ +   L
Sbjct: 230  LNKMLEELRLERKKLIEDYEG--KLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADL 287

Query: 613  LSTAAAQ---LTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLKQEKKKLHQ 669
                  Q   L   I K +    + +D+   LL++ Q ++ +     +N+++  +K+L  
Sbjct: 288  RKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQ-KLQTALAIAENNVQVLQKQLDD 346

Query: 670  KLITKRRRELLQKHREQRREQASVGEAFRTVEDAGQYLHQKRSLMEEHGATLEELQERLD 729
                +    LL KH+E   E A+  E  R  + A   +     L   H   L+  Q    
Sbjct: 347  A--KEGEMALLSKHKEVESELAAARE--RLQQQASDLV-----LKASHIGMLQATQ-MTQ 396

Query: 730  QAALDDLRTLTLSLFEKATD-ELRRLQNSAMTQELLKRGVPWLFLQQILEEHGKEMAARA 788
            +  + DL +    + E+ +  E  R    + TQ L +        QQILE   K   A+ 
Sbjct: 397  EVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQK-----QQILELEKKVNEAKR 451

Query: 789  EQLEGEERDRDQEGVQSVRQRLKDDAP---EAVTEEQAELRRWEHLIFMKLCSSVFSLSE 845
             Q E  ER+     +++++ RL+++     EA ++   EL  W+H + ++   S     +
Sbjct: 452  TQQEYYERE-----LKNLQSRLEEEVTQLNEAHSKTLEELA-WKHHMAIEAVHSNAIRDK 505

Query: 846  EELLRMRQEVHGCFAQMDRSLALPKIRARVLLQQFQTAWREAEFVKLDQAVAAPEL--QQ 903
            ++L    +E H             K+       Q Q      + V  D+   A +     
Sbjct: 506  KKLQMDLEEQHN----------KDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHL 555

Query: 904  QSKVRKSRSKSKSKGELL------KKCIEDKIHLCEEQASE--DLVEKVRGELLRERVQR 955
            Q  VRKS     S   L+      ++ +++++ L ++   E  D +  V GEL +ER Q 
Sbjct: 556  QDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQH 615

Query: 956  MEAQEGGFAQSLVALQFQKASRVTETLSAYTALLSIQDLLLEELSASEMLTKSACTQILE 1015
             E        ++ A++ ++  +V +            DL   E+  +E L +  C+++ E
Sbjct: 616  EE--------TIAAMKEEEKLKVDKMA---------HDL---EIKWTENL-RQECSKLRE 654

Query: 1016 SHSRELQELERKLEDQLVQQEAAQQQQALASWQQWVADGPGILNEPGEVDSERQVSTVLH 1075
                + +E ++    QL+Q +  ++  A  SWQ+ V D   +LN+   +    ++     
Sbjct: 655  ELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVED---LLNQISLLKQNLEIQ---- 707

Query: 1076 QALSKSQTLLEQHQ-QCLREEQQNSVVLEDLLE 1107
              LS+SQT L+Q Q Q  +E Q+ +  LE+L E
Sbjct: 708  --LSQSQTSLQQLQAQFTQERQRLTQELEELEE 738


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score = 68.2 bits (165), Expect = 5e-11
 Identities = 176/792 (22%), Positives = 321/792 (40%), Gaps = 80/792 (10%)

Query: 363  QMIDILSSEDPGSMLQALEELEIATLNRADADLEACRTQISKDIIALLLKNLTSSGHLSP 422
            + ++ L  E    +    ++L++A   R  A     + Q  K  ++  ++ L +    + 
Sbjct: 604  KQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETAR 663

Query: 423  QVERKMSAVFKKQFLLLENEIQEEYDRKMVALTAECDLETRKKMENQYQREMMAMEEAEE 482
            Q + +  A   +  L L +E Q+  +++ VA   +   E  + ++   +    ++EE + 
Sbjct: 664  QEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKR 723

Query: 483  LLKRAGERSAVECSNLLRTLHGLEQEHLRKSLALQQE-----------EDFAKAHRQLAV 531
                A E      S L      L ++H R+   L++E           +   +AH+    
Sbjct: 724  RAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETE 783

Query: 532  FQRNELHSIFFTQIKSAIFKGELKPEAAKMLLQNYSKIQENVEELMDFFQASKRYHLSKR 591
              R EL      Q  +     +L  E A    + Y   Q+   +    FQ      L   
Sbjct: 784  VLRRELAEAMAAQHTAESECEQLVKEVAAW-RERYEDSQQEEAQYGAMFQE----QLMTL 838

Query: 592  FGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTEVFS 651
                E   Q LQ ++ +V G+ S +  Q++   Q++E A  L  +    L +  + EV +
Sbjct: 839  KEECEKARQELQEAKEKVAGIESHSELQISR--QQNELA-ELHANLARALQQVQEKEVRA 895

Query: 652  IKQKLDNDLKQEKKKLHQKLITKRRRELLQKHREQRREQASVGEAFRTVEDAGQYLHQKR 711
              QKL +DL   ++K+        R E L +   +++E AS  E  +    AG    Q  
Sbjct: 896  --QKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETAS-RELVKEPARAGD--RQPE 950

Query: 712  SLMEEHGATLEELQERLDQAALDDLRTLTLSLFEKATDELRRLQNSAMT---QELLKRGV 768
             L E+ G      Q    QAAL  +        E+  +EL RL+ + M    Q+  +RG 
Sbjct: 951  WLEEQQGR-----QFCSTQAALQAMEREA----EQMGNELERLRAALMESQGQQQEERGQ 1001

Query: 769  PWLFLQQILEEHGKEMA----ARAEQLEGEERDRDQEGVQSVR-QRLKDDAPEAVTE--- 820
                + ++ +E G+  A     +A + E E R ++    Q V    L++    A+TE   
Sbjct: 1002 QEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEG 1061

Query: 821  ---EQAELRRWEHLIFM---KLCSSVFSLSEEELLRMRQEVHGCFAQMDRS-------LA 867
               E A+LR  E        +L  +V  L E+   + ++   G  AQ + +         
Sbjct: 1062 KDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPK 1121

Query: 868  LPKIRARVLLQQFQTAWREAEFVKLDQAVAAPELQQQSKVRKSRSKSKSKGELLKKCIED 927
            L  +RA V   + Q   ++ +   L++++ A         R SR++  S  E L+  +E+
Sbjct: 1122 LEALRAEVSKLEQQCQKQQEQADSLERSLEAE--------RASRAERDSALETLQGQLEE 1173

Query: 928  KIHLCEEQASEDLVEKVRGEL--LRERVQRMEAQEGGFAQSLVALQFQKASRVTETLSAY 985
            K    E   S+  +   + EL   R +VQ     E  + ++ VA   Q+A R    +S+ 
Sbjct: 1174 KAQ--ELGHSQSALASAQRELAAFRTKVQDHSKAEDEW-KAQVARGRQEAERKNSLISSL 1230

Query: 986  TALLSIQD-LLLEELSASEMLTKSACTQILESHSRELQELERKLEDQLVQQEAAQQQQAL 1044
               +SI +  +LE+   S+ L +     ++ + S + Q+LE +L  +L+Q E A      
Sbjct: 1231 EEEVSILNRQVLEKEGESKELKR-----LVMAESEKSQKLEERL--RLLQAETASNSARA 1283

Query: 1045 ASWQQWVADGPGILNEPGEVDSERQVSTVLHQALSKSQTLLEQHQQCLREEQQNSVVLED 1104
            A     + +    L E  E + +R  S  L Q L+      E+  Q L+  Q+     E 
Sbjct: 1284 AERSSALREEVQSLRE--EAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQ 1341

Query: 1105 LLENMEADTFAT 1116
             L  ++ +  +T
Sbjct: 1342 ALSTLQLEHTST 1353



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 164/794 (20%), Positives = 315/794 (39%), Gaps = 131/794 (16%)

Query: 394  DLEACRTQISKDIIALLLKNLTSSGHLSPQVERKMSAVFKKQFLLLENEIQEEYDR---- 449
            DL+  ++Q+ + I  L  +N    G LS ++    S + + Q  L  NE+ EE+ +    
Sbjct: 301  DLKTEKSQMDRKINQLSEEN----GDLSFKLREFASHLQQLQDAL--NELTEEHSKATQE 354

Query: 450  ---KMVALTAECD--LETRKKMENQYQREMMAMEEAEELLKRAGERSAVECSNLLRTLHG 504
               K   L  E    L+ +K +E + +     + + EE L +  +    E   +L  +  
Sbjct: 355  WLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDV-- 412

Query: 505  LEQEHLRKSLA-LQQEEDFAKAHRQLAVFQRNELHSIFFTQIKSAIFKGELKPEAAKML- 562
            L+ E L++  A L       +A  ++   +R +  +    +      +G  + E  ++  
Sbjct: 413  LQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAE------RGHFEEEKQQLSS 466

Query: 563  --------LQNYSKIQENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLS 614
                    + N S+ +E +E+      A     ++        L   +Q  +  + GL  
Sbjct: 467  LITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQ 526

Query: 615  TAA---AQLTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLKQEKKKLHQKL 671
             A    AQL   +Q+ E+A      Q+E               +L + LKQ++++L  K 
Sbjct: 527  QAKEKQAQLAQTLQQQEQASQGLRHQVE---------------QLSSSLKQKEQQL--KE 569

Query: 672  ITKRRRELLQKHREQRREQASVGEAFRTVEDAGQYLHQKRSLMEEHGATLEELQERLDQA 731
            + +++    Q H +Q    A   EA     DA   L Q  +L +E  A LE LQ++L  A
Sbjct: 570  VAEKQEATRQDHAQQLATAAEEREASLRERDAA--LKQLEALEKEKAAKLEILQQQLQVA 627

Query: 732  --ALDDLRTLTLSLFEKATDELRRLQNSAMTQELLKRGVPWLFLQQILEEHGKEMAARAE 789
              A D  +T       +  +  R+++      E  ++           E+H  E  A+  
Sbjct: 628  NEARDSAQTSVTQAQREKAELSRKVEELQACVETARQ-----------EQH--EAQAQVA 674

Query: 790  QLEGEERDRDQEGVQSVRQRLKDDAPEAVTEEQAELRRWEHLIFMKLCSSVFSLSEEELL 849
            +LE + R   Q+  +           E V +E+ +L+     +   L  +  SL EE   
Sbjct: 675  ELELQLRSEQQKATEK----------ERVAQEKDQLQEQLQALKESLKVTKGSLEEE--- 721

Query: 850  RMRQEVHGCFAQMDRSLALPKIRARVLLQQFQTAWREAEFVKLDQAVAAPELQQQSKVRK 909
              ++       +  R ++  K   R L++Q +   +E E  +  +      LQQ  +  +
Sbjct: 722  --KRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQ 779

Query: 910  SRSKSKSKGELLKKCIEDKI---HLCEEQASEDLVEKVRGELLR-ERVQRMEAQEGG-FA 964
            + +      E+L++ + + +   H  E +  E LV++V     R E  Q+ EAQ G  F 
Sbjct: 780  AET------EVLRRELAEAMAAQHTAESEC-EQLVKEVAAWRERYEDSQQEEAQYGAMFQ 832

Query: 965  QSLVALQFQKASRVTETLSAYTALLSIQDLLLEELSASEMLTKSACTQILESH---SREL 1021
            + L+ L+ +      E   A   +  I+       S SE+       ++ E H   +R L
Sbjct: 833  EQLMTLKEECEKARQELQEAKEKVAGIE-------SHSELQISRQQNELAELHANLARAL 885

Query: 1022 QEL-ERKLEDQLVQQEAAQQQQALASWQQWVADGPGILNEPGEVDSERQVSTVLHQALSK 1080
            Q++ E+++  Q +  + +  Q+ +A+  + VA    ++ + GE     Q  T   + + +
Sbjct: 886  QQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGE-----QQETASRELVKE 940

Query: 1081 SQTLLEQHQQCLREEQQNSVVLEDLLENMEADTFATLCSQELRLASYLARMAMVPGATLR 1140
                 ++  + L E+Q                     CS +  L + + R A   G  L 
Sbjct: 941  PARAGDRQPEWLEEQQGRQ-----------------FCSTQAALQA-MEREAEQMGNELE 982

Query: 1141 RLLSVVLPTASQPQ 1154
            RL + ++ +  Q Q
Sbjct: 983  RLRAALMESQGQQQ 996



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 98/462 (21%), Positives = 186/462 (40%), Gaps = 42/462 (9%)

Query: 685  EQRREQASVGEAFRTVEDAGQYLHQKRSLMEEHGATLEELQERLDQAALDDLRTLTLSLF 744
            + RR +  + +     ++    L + R L+ E  A +  +Q+R+D+ AL + +     L 
Sbjct: 215  QMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLE 274

Query: 745  EKATDELRRLQNSAMTQELLKRGVPWLFLQQILEEHGKEMAARAEQLEGEERDRD--QEG 802
             K  +ELR  +N ++T  L +     L   Q L+    +M  +  QL  E  D       
Sbjct: 275  PKELEELRD-KNESLTMRLHET----LKQCQDLKTEKSQMDRKINQLSEENGDLSFKLRE 329

Query: 803  VQSVRQRLKDDAPEAVTEEQAELRRWEHLIFMKLCSSVFSLSEEELLRMRQEV-HGCFAQ 861
              S  Q+L+D   E   E     + W             +L +++ L  + E+  G  +Q
Sbjct: 330  FASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQ 389

Query: 862  MDRSLAL-----PKIRARVL--LQQFQTAWREAEFVKLDQAVAAPELQQQSKVRKSRSKS 914
            ++  L+      P+ +  VL  + Q +T  +EA        +AA   Q Q++V    ++ 
Sbjct: 390  LEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEA------ATLAANNTQLQARVEMLETE- 442

Query: 915  KSKGELLKKCIEDKIHLCEE-QASEDLVEKVRGELLRERVQRMEAQEGGFAQSLVALQFQ 973
              +G+   K + ++ H  EE Q    L+  ++  +      + E ++   A     L  Q
Sbjct: 443  --RGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHG-ARLTAQ 499

Query: 974  KASRVTETLSAYTALLSIQDLLLEELSASEMLTKSACTQILESHSRELQELERKLEDQLV 1033
             AS +T  L+   A +  QD  L  L       ++   Q L+   +  Q L  ++E    
Sbjct: 500  VAS-LTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSS 558

Query: 1034 QQEAAQQQQALASWQQWVADGPGILNEPGEVDSERQVSTVLHQ---ALSKSQTLLEQHQQ 1090
              +  +QQ    + +Q          E    D  +Q++T   +   +L +    L+Q + 
Sbjct: 559  SLKQKEQQLKEVAEKQ----------EATRQDHAQQLATAAEEREASLRERDAALKQLEA 608

Query: 1091 CLREEQQNSVVLEDLLE--NMEADTFATLCSQELRLASYLAR 1130
              +E+     +L+  L+  N   D+  T  +Q  R  + L+R
Sbjct: 609  LEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSR 650


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 160/808 (19%), Positives = 337/808 (41%), Gaps = 96/808 (11%)

Query: 381  EELEIATLNRADADLEACRTQISKDIIALLLKNLTSSGHLSPQVERKMSAVFKKQFLLLE 440
            ++ E+  LN    D +A  +Q+ K +  L  +       L  + ER   A  +K    L 
Sbjct: 1083 KDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEEL--EAERTARAKVEKLRSDLS 1140

Query: 441  NEIQEEYDRKMVALTA-ECDLETRKKMENQYQREMMAMEEAE-------ELLKRAGERSA 492
             E++E  +R   A  A    +E  KK E ++Q+    +EEA          L++    S 
Sbjct: 1141 RELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSV 1200

Query: 493  VECSNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVFQRNELHSIFFT---QIKSAI 549
             E    +  L  ++Q+  ++    + E D   ++ +  +  +  L  +  T   Q+    
Sbjct: 1201 AELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHR 1260

Query: 550  FKGELKPEAAKMLLQNYSKIQENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRV 609
             K E    +   L    +K+Q    EL       +        G   Y  Q L+  + ++
Sbjct: 1261 SKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTY-TQQLEDLKRQL 1319

Query: 610  QGLLSTAAAQLTHLIQ--KHE----RAGYLDEDQ----MEMLLERAQTEVFSIKQKLDND 659
            +  +    A L H +Q  +H+    R  Y +E +    ++ +L +A +EV   + K + D
Sbjct: 1320 EEEVKAKNA-LAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETD 1378

Query: 660  -------LKQEKKKLHQKLITKRRRELLQ------------KHREQRREQASVGEAFRTV 700
                   L++ KKKL Q+L  +   E ++            KHR Q   +  + +  R+ 
Sbjct: 1379 AIQRTEELEEAKKKLAQRL--QEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSN 1436

Query: 701  EDAGQYLHQKRS---LMEEHGATLEELQERLDQAALDDLRTLTLSLF------------- 744
              A     ++R+   ++ E     EE Q  L+ +   + R+L+  LF             
Sbjct: 1437 AAAAALDKKQRNFDKILAEWKQKYEESQSELESSQ-KEARSLSTELFKLKNAYEESLEHL 1495

Query: 745  EKATDELRRLQN--SAMTQELLKRGVPWLFLQQILEEHGKEMAARAEQLEGEERDRDQEG 802
            E    E + LQ   S +T++L   G     L+++ ++   E       LE  E   + E 
Sbjct: 1496 ETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEE 1555

Query: 803  VQSVRQRLKDDAPEAVTE----------EQAELRRWEHLIFMKLCSSVFSLSEEELLRMR 852
             + +R +L+ +  +A  E          EQA+      +  ++      + S  E LR++
Sbjct: 1556 GKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVK 1615

Query: 853  QEVHGCFAQMDRSLALPK---IRARVLLQQFQTAWREAEFVKLDQAVAAPELQQQSKVRK 909
            +++ G   +M+  L+        A+  ++  Q+  ++ + ++LD AV A +  +++    
Sbjct: 1616 KKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQ-IQLDDAVRANDDLKENIAIV 1674

Query: 910  SRSKSKSKGELLK-KCIEDKIHLCEEQASEDLVE-KVRGELLRERVQRMEAQEGGFAQSL 967
             R  +  + EL + + + ++     + A ++L+E   R +LL  +   +  Q+      L
Sbjct: 1675 ERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADL 1734

Query: 968  VALQFQKASRVTETLSAYT-ALLSIQD--LLLEELSASEMLTKSACTQILESHSRELQEL 1024
              LQ +    V E  +A   A  +I D  ++ EEL   E  T +   ++ ++  + +++L
Sbjct: 1735 SQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELK-KEQDTSAHLERMKKNMEQTIKDL 1793

Query: 1025 ERKLED--QLVQQEAAQQQQALASWQQWVADGPGILNEPGEVDSERQVSTVLHQALSKSQ 1082
            + +L++  Q+  +   +Q Q L +          +     E+++E++ +    + + KS+
Sbjct: 1794 QHRLDEAEQIALKGGKKQLQKLEA---------RVRELENELEAEQKRNAESVKGMRKSE 1844

Query: 1083 TLLEQHQQCLREEQQNSVVLEDLLENME 1110
              +++      E+++N + L+DL++ ++
Sbjct: 1845 RRIKELTYQTEEDRKNLLRLQDLVDKLQ 1872



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 142/705 (20%), Positives = 266/705 (37%), Gaps = 100/705 (14%)

Query: 471  QREMMAMEEAEELLKRAGERSAVECSNLLRTLHGLEQEHLRKSLALQQEED-FAKAHRQL 529
            ++EM +M+E    LK A E+S      L   +  L QE     L +Q E+D  A A  + 
Sbjct: 846  EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERC 905

Query: 530  AVFQRNELHSIFFTQIKSAIFKGELKPEAAKMLLQNYSKIQENVEEL--------MDFFQ 581
                +N++      ++K    + E + E    L     K+++   EL        +   +
Sbjct: 906  DQLIKNKIQ--LEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAK 963

Query: 582  ASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDEDQME-- 639
              K  H +      E  V+NL      +  +++    +   L + H++A  LD+ Q E  
Sbjct: 964  VEKEKHAT------ENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQA--LDDLQAEED 1015

Query: 640  --MLLERAQTEVFSIKQKLDNDLKQEKK----------------KLHQKLITKRRRELLQ 681
                L +A+ ++      L+  L+QEKK                KL Q+ I     +  Q
Sbjct: 1016 KVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQ 1075

Query: 682  KHREQRREQASVGEAFRTVEDAGQYLHQKRSLMEEHGATLEELQERLD-----QAALDDL 736
                 +++   +      +ED      Q +  ++E  A +EEL+E L+     +A ++ L
Sbjct: 1076 LDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKL 1135

Query: 737  RTLTLSLFEKATDELRRLQNSAMTQELL--KRGVPWLFLQQILEEHGKEMAARAEQLEGE 794
            R+      E+ ++ L     +   Q  +  KR   +  +++ LEE   +  A A  L  +
Sbjct: 1136 RSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKK 1195

Query: 795  ERDRDQE------GVQSVRQRLKDDAPEAVTEEQAELRRWEHLI-----FMKLCSSVFSL 843
              D   E       +Q V+Q+L+ +  E   E        E +I       K+C ++   
Sbjct: 1196 HADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTL--- 1252

Query: 844  SEEELLRMRQEVHGCFAQMDRSL-ALPKIRARVLLQQFQTAWREAEFVKLDQAVAAPEL- 901
             E+++   R +      +  RS+  L   RA++  +  + + +  E   L   +   +L 
Sbjct: 1253 -EDQMNEHRSKAE----ETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLT 1307

Query: 902  --QQQSKVRKSRSKSKSKGELLKKCIEDKIHLCE---EQASEDLVEKVRGELLRERVQRM 956
              QQ   +++   +       L   ++   H C+   EQ  E+   + + EL R     +
Sbjct: 1308 YTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEE--TEAKAELQRV----L 1361

Query: 957  EAQEGGFAQSLVALQFQKASRVTETLSAYTALLSIQDLLLEELSASEMLTKSACTQILES 1016
                   AQ     +     R  E   A   L       L+E   +     + C+ + ++
Sbjct: 1362 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ----RLQEAEEAVEAVNAKCSSLEKT 1417

Query: 1017 HSRELQELERKLEDQLVQQEAAQQQQA------------LASWQQWVADGPGILNEPGEV 1064
              R    L+ ++ED +V  E +    A            LA W+Q   +    L    + 
Sbjct: 1418 KHR----LQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQK- 1472

Query: 1065 DSERQVSTVLHQALSKSQTLLEQHQQCLREEQQNSVVLEDLLENM 1109
               R +ST L +  +  +  LE  +   RE +     + DL E +
Sbjct: 1473 -EARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQL 1516


>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
          Length = 1460

 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 141/625 (22%), Positives = 246/625 (39%), Gaps = 101/625 (16%)

Query: 554  LKPEAAKMLLQNYSKIQENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLL 613
            L+ +  KM        QE  EE++   Q  K   LS     RE L + ++  E R++   
Sbjct: 611  LESKQEKMQQLREKLCQEEEEEILRLHQ-QKEQSLSSL---RERLQKAIEEEEARMREEE 666

Query: 614  STAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLKQEKKKLHQKLIT 673
            S   + L   +Q   +A   DEDQ+       +  +  ++++L++  K E+  L QK   
Sbjct: 667  SQRLSWLRAQVQSSTQA---DEDQIRA---EQEASLQKLREELESQQKAERASLEQK--- 717

Query: 674  KRRRELLQKHREQ-----RREQASVGEAF-RTVEDAGQYLHQKR-----SLMEEHGATLE 722
               R++L++ +E+     + EQA++  A  + ++   + L  +R     +L +EH A LE
Sbjct: 718  --NRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELE 775

Query: 723  ELQERLDQAALDDLRTLTLSLFEKATDELRRLQN-----------------------SAM 759
             L   L+    + + +L   + E    E  +LQ                        S++
Sbjct: 776  RLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSL 835

Query: 760  TQELLKR--GVPWLFLQQILEEHGKEMAARAEQLEGEER--------------------- 796
             +E  +   G     L ++ EEH + MA   EQ E EER                     
Sbjct: 836  LREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAH 895

Query: 797  DRDQEGVQSVRQRLKDDAPEAVTEEQAELRRWE-----HLIFMKLCSSVFSLSEEELLRM 851
            +R+ E V+  + +  +D      E++ +L+  E         +K   ++  + EE   R 
Sbjct: 896  ERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETARRE 955

Query: 852  RQEVHGCFAQMDRSLALPKIRARVLLQQFQTAWREAEFVKLDQAVAAPELQQQSKVRKSR 911
            +Q++      + R +AL    A    QQ + A +E   + L       E+  + + RK  
Sbjct: 956  KQQL----LDVQRQVALKSEEATATHQQLEEAQKEHTHL-LQSNQQLREILDELQARK-- 1008

Query: 912  SKSKSKGELLKKCIEDKIHLCEEQASEDLVEKVRGELLRERVQRMEAQEGGFAQSLVALQ 971
             K +S+ +LL+        L +  +S +   + +  LLRE           F   L    
Sbjct: 1009 LKLESQVDLLQ---AQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIED 1065

Query: 972  FQKASRVTETLSAYTAL-LSIQDLLLEELSASEML-TKSACTQILESHSRELQELERKLE 1029
             +K+    +T    ++L  S +DL L+ LS+  +    SA    L S    L +  R + 
Sbjct: 1066 LRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTRSMR 1125

Query: 1030 DQLVQQEAAQQ--QQALASWQQWVADGPGIL----------NEPGEVDSERQVSTVLHQA 1077
             +    +AAQQ  +  LAS Q+   D PGI            E   +D  +      H  
Sbjct: 1126 RRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKGHNL 1185

Query: 1078 LSKSQTLLEQHQQCLREEQQNSVVL 1102
            L K +  L Q +  L EE  +   L
Sbjct: 1186 LKKKEEKLNQLESSLWEEASDEGTL 1210



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 84/361 (23%), Positives = 152/361 (42%), Gaps = 63/361 (17%)

Query: 418  GHLSPQVER-------KMSAVFKKQFLLLENEIQEEYDRKMVALTAECDLETRKKMENQY 470
            GHL+ ++ER       ++  V ++Q   LE+  +   +++      E DLETR K     
Sbjct: 882  GHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAK---DV 938

Query: 471  QREMMAMEEAEELLKRAGERSAVECSNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLA 530
            +  +  +E  EE  +R       E   LL          +++ +AL+ EE  A  H+QL 
Sbjct: 939  KARLALLEVQEETARR-------EKQQLL---------DVQRQVALKSEEATA-THQQLE 981

Query: 531  VFQRNELHSIFFTQ----IKSAIFKGELKPEAAKMLLQNYS-KIQENVEELMDFFQASKR 585
              Q+   H +   Q    I   +   +LK E+   LLQ  S ++Q++   L    +A K+
Sbjct: 982  EAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLE--AEAQKK 1039

Query: 586  YHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDEDQMEMLLERA 645
             HL +     E         +  ++ L  +         Q  E +  L + + ++ L+  
Sbjct: 1040 QHLLREVTVEENNASPHFEPDLHIEDLRKSLGTN-----QTKEVSSSLSQSKEDLYLDSL 1094

Query: 646  QT-EVFSIKQKLDNDLKQEKKKLHQKLITKRRRELLQKHREQ--RREQASVGEAF----- 697
             +  V+ +       L+  K+ L Q+  + RRR+   K  +Q  R E AS  E       
Sbjct: 1095 SSHNVWHLLSAEGVALRSAKEFLVQQTRSMRRRQTALKAAQQHWRHELASAQEVAKDPPG 1154

Query: 698  --------RTVEDAGQYLHQKRSLMEEHGATLEELQERLDQAALDDLRTLTLSLFEKATD 749
                    + +E   ++L + +S M +    L++ +E+L+Q        L  SL+E+A+D
Sbjct: 1155 IKALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQ--------LESSLWEEASD 1206

Query: 750  E 750
            E
Sbjct: 1207 E 1207



 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 96/439 (21%), Positives = 176/439 (40%), Gaps = 75/439 (17%)

Query: 778  EEHGKEMAARAEQLEGEERDRDQEGVQSVRQRLKDDAPEAVTEEQAELRRWEHLIFMKLC 837
            E    E  A  EQL        +E V  V ++ +    E+  E+  +LR        KLC
Sbjct: 574  EVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLRE-------KLC 626

Query: 838  SSVFSLSEEELLRMRQEVHGCFAQMDRSL--ALPKIRARVLLQQFQT-AWREAEFVKLDQ 894
                   EEE+LR+ Q+     + +   L  A+ +  AR+  ++ Q  +W  A+     Q
Sbjct: 627  QE----EEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQ 682

Query: 895  AVAAP-ELQQQSKVRKSRSKSKSKGELLKKCIEDKIHLCEEQASEDLVEKVRGE-----L 948
            A       +Q++ ++K R + +S+ +  +  +E K     EQ  E++    + E      
Sbjct: 683  ADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNA 742

Query: 949  LRERV--QRMEAQEGGFAQSLVALQFQKASRVTETLSAYTA-----LLSIQDLLLEELSA 1001
             +E+   Q  E  EG   +++  L+ + ++ +    S+  A     + S+Q  + E    
Sbjct: 743  AKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQK 802

Query: 1002 SEMLTKSACTQI-----------------LESHSREL-QELERKLEDQLVQQEAAQQQQA 1043
             E   +    Q+                 L S  RE  QE+E + E +L + +   QQ  
Sbjct: 803  EEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVM 862

Query: 1044 LASWQQWVADGPGILNE-----PGEVDS-----ERQVSTVLHQALSKSQTLLEQHQQCLR 1093
              + +Q+ A+      E      GE++      ER++ TV  +   + + L  +H    R
Sbjct: 863  AKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRH----R 918

Query: 1094 EEQQNSVVLEDLLENMEADTFATLCSQELRLASYLARMAM--VPGATLRRLLSVVLPTAS 1151
            E+++        L+++E D        E R     AR+A+  V   T RR    +L    
Sbjct: 919  EQERK-------LQDLELDL-------ETRAKDVKARLALLEVQEETARREKQQLLDVQR 964

Query: 1152 QPQLLALLDSATERHVDHA 1170
            Q  L +   +AT + ++ A
Sbjct: 965  QVALKSEEATATHQQLEEA 983


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.130    0.368 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,724,711
Number of Sequences: 37866
Number of extensions: 2131367
Number of successful extensions: 15092
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 38
Number of HSP's successfully gapped in prelim test: 651
Number of HSP's that attempted gapping in prelim test: 11704
Number of HSP's gapped (non-prelim): 2473
length of query: 1308
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1194
effective length of database: 13,930,794
effective search space: 16633368036
effective search space used: 16633368036
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.