Search of human proteins with 93141001

Search of human proteins with 93141001

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|93141001 testican 3 isoform 2 [Homo sapiens]
         (436 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|93141001 testican 3 isoform 2 [Homo sapiens]                       937   0.0  
gi|93141003 testican 3 isoform 1 [Homo sapiens]                       926   0.0  
gi|4759164 sparc/osteonectin, cwcv and kazal-like domains proteo...   479   e-135
gi|7662036 sparc/osteonectin, cwcv and kazal-like domains proteo...   414   e-116
gi|190194423 SPARC-like 1 [Homo sapiens]                               68   1e-11
gi|190341024 SPARC-like 1 [Homo sapiens]                               68   1e-11
gi|115298674 nidogen 1 precursor [Homo sapiens]                        65   2e-10
gi|68448544 CD74 antigen isoform a [Homo sapiens]                      61   2e-09
gi|144953895 nidogen 2 precursor [Homo sapiens]                        60   5e-09
gi|4507171 secreted protein, acidic, cysteine-rich [Homo sapiens]      59   9e-09
gi|55770862 thyroglobulin [Homo sapiens]                               54   4e-07
gi|62243068 insulin-like growth factor binding protein 3 isoform...    52   8e-07
gi|62243248 insulin-like growth factor binding protein 3 isoform...    52   8e-07
gi|11321593 insulin-like growth factor binding protein 6 [Homo s...    52   1e-06
gi|54873613 agrin [Homo sapiens]                                       52   1e-06
gi|197313714 sparc/osteonectin, cwcv and kazal-like domains prot...    51   2e-06
gi|10834982 insulin-like growth factor binding protein 5 [Homo s...    49   7e-06
gi|5901956 follistatin-like 1 precursor [Homo sapiens]                 49   1e-05
gi|24308277 SPARC related modular calcium binding 2 [Homo sapiens]     47   3e-05
gi|78190498 secreted modular calcium-binding protein 1 isoform 1...    47   3e-05
gi|11545873 secreted modular calcium-binding protein 1 isoform 2...    47   3e-05
gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]      45   1e-04
gi|19924161 RPB5-mediating protein isoform b [Homo sapiens]            44   2e-04
gi|19924159 RPB5-mediating protein isoform a [Homo sapiens]            44   2e-04
gi|42740903 MTERF domain containing 2 [Homo sapiens]                   44   4e-04
gi|55956788 nucleolin [Homo sapiens]                                   44   4e-04
gi|5453652 follistatin isoform FST317 precursor [Homo sapiens]         44   4e-04
gi|7242222 follistatin isoform FST344 precursor [Homo sapiens]         44   4e-04
gi|4504615 insulin-like growth factor binding protein 1 precurso...    43   6e-04
gi|54792136 follistatin-like 4 [Homo sapiens]                          43   6e-04

>gi|93141001 testican 3 isoform 2 [Homo sapiens]
          Length = 436

 Score =  937 bits (2422), Expect = 0.0
 Identities = 436/436 (100%), Positives = 436/436 (100%)

Query: 1   MLKVSAVLCVCAAAWCSQSLAAAAAVAAAGGRSDGGNFLDDKQWLTTISQYDKEVGQWNK 60
           MLKVSAVLCVCAAAWCSQSLAAAAAVAAAGGRSDGGNFLDDKQWLTTISQYDKEVGQWNK
Sbjct: 1   MLKVSAVLCVCAAAWCSQSLAAAAAVAAAGGRSDGGNFLDDKQWLTTISQYDKEVGQWNK 60

Query: 61  FRDEVEDDYFRTWSPGKPFDQALDPAKDPCLKMKCSRHKVCIAQDSQTAVCISHRRLTHR 120
           FRDEVEDDYFRTWSPGKPFDQALDPAKDPCLKMKCSRHKVCIAQDSQTAVCISHRRLTHR
Sbjct: 61  FRDEVEDDYFRTWSPGKPFDQALDPAKDPCLKMKCSRHKVCIAQDSQTAVCISHRRLTHR 120

Query: 121 MKEAGVDHRQWRGPILSTCKQCPVVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCE 180
           MKEAGVDHRQWRGPILSTCKQCPVVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCE
Sbjct: 121 MKEAGVDHRQWRGPILSTCKQCPVVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCE 180

Query: 181 GHCPCPSDKPTSTSRNVKRACSDLEFREVANRLRDWFKALHESGSQNKKTKTLLRPERSR 240
           GHCPCPSDKPTSTSRNVKRACSDLEFREVANRLRDWFKALHESGSQNKKTKTLLRPERSR
Sbjct: 181 GHCPCPSDKPTSTSRNVKRACSDLEFREVANRLRDWFKALHESGSQNKKTKTLLRPERSR 240

Query: 241 FDTSILPICKDSLGWMFNRLDTNYDLLLDQSELRSIYLDKNEQCTKAFFNSCDTYKDSLI 300
           FDTSILPICKDSLGWMFNRLDTNYDLLLDQSELRSIYLDKNEQCTKAFFNSCDTYKDSLI
Sbjct: 241 FDTSILPICKDSLGWMFNRLDTNYDLLLDQSELRSIYLDKNEQCTKAFFNSCDTYKDSLI 300

Query: 301 SNNEWCYCFQRQQDPPCQTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVGQCW 360
           SNNEWCYCFQRQQDPPCQTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVGQCW
Sbjct: 301 SNNEWCYCFQRQQDPPCQTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVGQCW 360

Query: 361 CVDRYGNEVMGSRINGVADCAIDFEISGDFASGDFHEWTDDEDDEDDIMNDEDEIEDDDE 420
           CVDRYGNEVMGSRINGVADCAIDFEISGDFASGDFHEWTDDEDDEDDIMNDEDEIEDDDE
Sbjct: 361 CVDRYGNEVMGSRINGVADCAIDFEISGDFASGDFHEWTDDEDDEDDIMNDEDEIEDDDE 420

Query: 421 DEGDDDDGGDDHDVYI 436
           DEGDDDDGGDDHDVYI
Sbjct: 421 DEGDDDDGGDDHDVYI 436


>gi|93141003 testican 3 isoform 1 [Homo sapiens]
          Length = 433

 Score =  926 bits (2394), Expect = 0.0
 Identities = 433/436 (99%), Positives = 433/436 (99%), Gaps = 3/436 (0%)

Query: 1   MLKVSAVLCVCAAAWCSQSLAAAAAVAAAGGRSDGGNFLDDKQWLTTISQYDKEVGQWNK 60
           MLKVSAVLCVCAAAWCSQSLAAAAAVAAAGGRSDGGNFLDDKQWLTTISQYDKEVGQWNK
Sbjct: 1   MLKVSAVLCVCAAAWCSQSLAAAAAVAAAGGRSDGGNFLDDKQWLTTISQYDKEVGQWNK 60

Query: 61  FRDEVEDDYFRTWSPGKPFDQALDPAKDPCLKMKCSRHKVCIAQDSQTAVCISHRRLTHR 120
           FRD   DDYFRTWSPGKPFDQALDPAKDPCLKMKCSRHKVCIAQDSQTAVCISHRRLTHR
Sbjct: 61  FRD---DDYFRTWSPGKPFDQALDPAKDPCLKMKCSRHKVCIAQDSQTAVCISHRRLTHR 117

Query: 121 MKEAGVDHRQWRGPILSTCKQCPVVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCE 180
           MKEAGVDHRQWRGPILSTCKQCPVVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCE
Sbjct: 118 MKEAGVDHRQWRGPILSTCKQCPVVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCE 177

Query: 181 GHCPCPSDKPTSTSRNVKRACSDLEFREVANRLRDWFKALHESGSQNKKTKTLLRPERSR 240
           GHCPCPSDKPTSTSRNVKRACSDLEFREVANRLRDWFKALHESGSQNKKTKTLLRPERSR
Sbjct: 178 GHCPCPSDKPTSTSRNVKRACSDLEFREVANRLRDWFKALHESGSQNKKTKTLLRPERSR 237

Query: 241 FDTSILPICKDSLGWMFNRLDTNYDLLLDQSELRSIYLDKNEQCTKAFFNSCDTYKDSLI 300
           FDTSILPICKDSLGWMFNRLDTNYDLLLDQSELRSIYLDKNEQCTKAFFNSCDTYKDSLI
Sbjct: 238 FDTSILPICKDSLGWMFNRLDTNYDLLLDQSELRSIYLDKNEQCTKAFFNSCDTYKDSLI 297

Query: 301 SNNEWCYCFQRQQDPPCQTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVGQCW 360
           SNNEWCYCFQRQQDPPCQTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVGQCW
Sbjct: 298 SNNEWCYCFQRQQDPPCQTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVGQCW 357

Query: 361 CVDRYGNEVMGSRINGVADCAIDFEISGDFASGDFHEWTDDEDDEDDIMNDEDEIEDDDE 420
           CVDRYGNEVMGSRINGVADCAIDFEISGDFASGDFHEWTDDEDDEDDIMNDEDEIEDDDE
Sbjct: 358 CVDRYGNEVMGSRINGVADCAIDFEISGDFASGDFHEWTDDEDDEDDIMNDEDEIEDDDE 417

Query: 421 DEGDDDDGGDDHDVYI 436
           DEGDDDDGGDDHDVYI
Sbjct: 418 DEGDDDDGGDDHDVYI 433


>gi|4759164 sparc/osteonectin, cwcv and kazal-like domains
           proteoglycan 1 precursor [Homo sapiens]
          Length = 439

 Score =  479 bits (1233), Expect = e-135
 Identities = 231/433 (53%), Positives = 288/433 (66%), Gaps = 16/433 (3%)

Query: 6   AVLCVCAAAWCSQSLAAAAAVAAAGGRSDG-GNFLDDKQWLTTISQYDKEVGQWNKFRDE 64
           AVL   AAAWC   + +    A AGG     GNFLD+ QWL+T+SQYD++   WN+FRD 
Sbjct: 5   AVLAAAAAAWCFLQVESRHLDALAGGAGPNHGNFLDNDQWLSTVSQYDRDK-YWNRFRD- 62

Query: 65  VEDDYFRTWSPGKPFDQALDPAKDPCLKMKCSRHKVCIAQDSQTAVCISHRRLTHRMKEA 124
             DDYFR W+P KPFDQALDP+KDPCLK+KCS HKVC+ QD QTA+C+S + L  R K+ 
Sbjct: 63  --DDYFRNWNPNKPFDQALDPSKDPCLKVKCSPHKVCVTQDYQTALCVSRKHLLPRQKKG 120

Query: 125 GVDHRQWRGPI-LSTCKQCPVVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHC 183
            V  + W GP  L  CK CPV   + VCGSDGH+Y+ +CKLE+ AC  GK ++  C+G C
Sbjct: 121 NVAQKHWVGPSNLVKCKPCPVAQSAMVCGSDGHSYTSKCKLEFHACSTGKSLATLCDGPC 180

Query: 184 PCPSDKPTSTSRNVKRACSDLEFREVANRLRDWFKALHESGSQNKKTKTLLRPERSRFDT 243
           PC  +      +  + AC+D E R +A+RL+DWF ALHE  ++  K  T     + RFDT
Sbjct: 181 PCLPEPEPPKHKAERSACTDKELRNLASRLKDWFGALHEDANRVIKP-TSSNTAQGRFDT 239

Query: 244 SILPICKDSLGWMFNRLDTNYDLLLDQSELRSIYLDKNEQCTKAFFNSCDTYKDSLISNN 303
           SILPICKDSLGWMFN+LD NYDLLLD SE+ +IYLDK E C K  FNSCD++KD  +SNN
Sbjct: 240 SILPICKDSLGWMFNKLDMNYDLLLDPSEINAIYLDKYEPCIKPLFNSCDSFKDGKLSNN 299

Query: 304 EWCYCFQRQQDPPCQTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVGQCWCVD 363
           EWCYCFQ+    PCQ E++ IQK    K LLG +IP C+E+GYYK TQCHGS GQCWCVD
Sbjct: 300 EWCYCFQKPGGLPCQNEMNRIQKLSKGKSLLGAFIPRCNEEGYYKATQCHGSTGQCWCVD 359

Query: 364 RYGNEVMGSRINGVADCAIDFEISGDFASGDFHEWTDDEDDEDDIMNDEDE--------- 414
           +YGNE+ GSR  G   C  + E SGDF SG      DD + E ++   + E         
Sbjct: 360 KYGNELAGSRKQGAVSCEEEQETSGDFGSGGSVVLLDDLEYERELGPKDKEGKLRVHTRA 419

Query: 415 IEDDDEDEGDDDD 427
           + +DDEDE DD +
Sbjct: 420 VTEDDEDEDDDKE 432


>gi|7662036 sparc/osteonectin, cwcv and kazal-like domains
           proteoglycan (testican) 2 isoform 2 [Homo sapiens]
          Length = 424

 Score =  414 bits (1064), Expect = e-116
 Identities = 204/413 (49%), Positives = 272/413 (65%), Gaps = 13/413 (3%)

Query: 21  AAAAAVAAAGGRSDG---GNFLDDKQWLTTISQYDKEVGQWNKFRDEVEDDYFRTWSPGK 77
           AAA A   A G  +G   GNF++D+QWL++ISQY  ++  WN+FRDEVEDDY ++W   +
Sbjct: 18  AAALAEGDAKGLKEGETPGNFMEDEQWLSSISQYSGKIKHWNRFRDEVEDDYIKSWEDNQ 77

Query: 78  PFDQALDPAKDPCLKMKCSRHKVCIAQDSQTAVCISHRRLTHRMKEAGVDHRQWRGPILS 137
             D+ALD  KDPC K+KCSRHKVCIAQ  Q A+CIS ++L HR+K+  V   +  G   S
Sbjct: 78  QGDEALDTTKDPCQKVKCSRHKVCIAQGYQRAMCISRKKLEHRIKQPTV---KLHGNKDS 134

Query: 138 TCKQCPVVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHCPCPSDK-PTSTSRN 196
            CK C +   + VCGSDGHTYS  CKLE QAC+  KQ++V+CEG CPCP+++  TST+  
Sbjct: 135 ICKPCHMAQLASVCGSDGHTYSSVCKLEQQACLSSKQLAVRCEGPCPCPTEQAATSTADG 194

Query: 197 VKRACSDLEFREVANRLRDWFKALHESGSQNKKTKTLLRPERSRFDTSILPICKDSLGWM 256
               C+  +  ++ +RLRDWF+ LHE+  QN    ++  P  S  D S+   CKDS+GWM
Sbjct: 195 KPETCTGQDLADLGDRLRDWFQLLHENSKQNGSASSVAGP-ASGLDKSLGASCKDSIGWM 253

Query: 257 FNRLDTNYDLLLDQSELRSIYLDKNEQCTKAFFNSCDTYKDSLISNNEWCYCFQRQQDPP 316
           F++LDT+ DL LDQ+EL +I LDK E C + FFNSCDTYKD  +S  EWC+CF R++ PP
Sbjct: 254 FSKLDTSADLFLDQTELAAINLDKYEVCIRPFFNSCDTYKDGRVSTAEWCFCFWREK-PP 312

Query: 317 CQTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVMGSRING 376
           C  EL  IQ ++  KK  G +IP CDEDGYY+  QC  S G CWCVD+ G E+ G+R +G
Sbjct: 313 CLAELERIQIQEAAKKKPGIFIPSCDEDGYYRKMQCDQSSGDCWCVDQLGLELTGTRTHG 372

Query: 377 VADCAIDFEISGDFASGDFHEWTDDEDDEDDIMNDEDEIEDDDEDEGDDDDGG 429
             DC      SGDF SG    W D+E+ E +     +E E+++ + G+ DDGG
Sbjct: 373 SPDCDDIVGFSGDFGSG--VGWEDEEEKETE--EAGEEAEEEEGEAGEADDGG 421


>gi|190194423 SPARC-like 1 [Homo sapiens]
          Length = 664

 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 68/263 (25%), Positives = 95/263 (36%), Gaps = 79/263 (30%)

Query: 86  AKDPCLKMKCSRHKVCIAQDSQTAVCISHRRLTHRMKEAGVDHRQWRGPILSTCKQCPVV 145
           A D C+  +C R  +C A       C+    +T                       CP  
Sbjct: 429 AVDSCMSFQCKRGHICKADQQGKPHCVCQDPVT-----------------------CPPT 465

Query: 146 YP-SPVCGSDGHTYSFQCKLEYQACVL-----GKQISVKCEGHCPCPSDKPTSTSRNVKR 199
            P   VCG+D  TY+  C L    C L     G Q+ +   G C      PT        
Sbjct: 466 KPLDQVCGTDNQTYASSCHLFATKCRLEGTKKGHQLQLDYFGAC---KSIPT-------- 514

Query: 200 ACSDLEFREVANRLRDWFK----ALHESGSQ-----NKKTKT------------------ 232
            C+D E  +   R+RDW K     L+E+ S+     N+K +                   
Sbjct: 515 -CTDFEVIQFPLRMRDWLKNILMQLYEANSEHAGYLNEKQRNKVKKIYLDEKRLLAGDHP 573

Query: 233 ---LLRPERSRFDTSILPICKDSLGWMFNRLDTN-YDLLLDQSELRSIY--LDKNEQCTK 286
              LLR  +  +   + P+      W F+ LD +  D +L  SEL  +   L   E C  
Sbjct: 574 IDLLLRDFKKNYHMYVYPV-----HWQFSELDQHPMDRVLTHSELAPLRASLVPMEHCIT 628

Query: 287 AFFNSCDTYKDSLISNNEWCYCF 309
            FF  CD  KD  I+  EW +CF
Sbjct: 629 RFFEECDPNKDKHITLKEWGHCF 651


>gi|190341024 SPARC-like 1 [Homo sapiens]
          Length = 664

 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 68/263 (25%), Positives = 95/263 (36%), Gaps = 79/263 (30%)

Query: 86  AKDPCLKMKCSRHKVCIAQDSQTAVCISHRRLTHRMKEAGVDHRQWRGPILSTCKQCPVV 145
           A D C+  +C R  +C A       C+    +T                       CP  
Sbjct: 429 AVDSCMSFQCKRGHICKADQQGKPHCVCQDPVT-----------------------CPPT 465

Query: 146 YP-SPVCGSDGHTYSFQCKLEYQACVL-----GKQISVKCEGHCPCPSDKPTSTSRNVKR 199
            P   VCG+D  TY+  C L    C L     G Q+ +   G C      PT        
Sbjct: 466 KPLDQVCGTDNQTYASSCHLFATKCRLEGTKKGHQLQLDYFGAC---KSIPT-------- 514

Query: 200 ACSDLEFREVANRLRDWFK----ALHESGSQ-----NKKTKT------------------ 232
            C+D E  +   R+RDW K     L+E+ S+     N+K +                   
Sbjct: 515 -CTDFEVIQFPLRMRDWLKNILMQLYEANSEHAGYLNEKQRNKVKKIYLDEKRLLAGDHP 573

Query: 233 ---LLRPERSRFDTSILPICKDSLGWMFNRLDTN-YDLLLDQSELRSIY--LDKNEQCTK 286
              LLR  +  +   + P+      W F+ LD +  D +L  SEL  +   L   E C  
Sbjct: 574 IDLLLRDFKKNYHMYVYPV-----HWQFSELDQHPMDRVLTHSELAPLRASLVPMEHCIT 628

Query: 287 AFFNSCDTYKDSLISNNEWCYCF 309
            FF  CD  KD  I+  EW +CF
Sbjct: 629 RFFEECDPNKDKHITLKEWGHCF 651


>gi|115298674 nidogen 1 precursor [Homo sapiens]
          Length = 1247

 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 25/39 (64%), Positives = 29/39 (74%)

Query: 335 GQYIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVMGSR 373
           G ++P CD  G+Y PTQCHGS G CWCVDR G EV G+R
Sbjct: 872 GLFVPECDAHGHYAPTQCHGSTGYCWCVDRDGREVEGTR 910


>gi|68448544 CD74 antigen isoform a [Homo sapiens]
          Length = 296

 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 32/77 (41%), Positives = 43/77 (55%), Gaps = 6/77 (7%)

Query: 317 CQTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVMGSRING 376
           CQ E+S+I          G + P CDE+G Y P QC+GS+G CWCV   G EV  +R  G
Sbjct: 213 CQEEVSHIPAVHP-----GSFRPKCDENGNYLPLQCYGSIGYCWCVFPNGTEVPNTRSRG 267

Query: 377 VADCAIDFEISGDFASG 393
             +C+   E+  D +SG
Sbjct: 268 HHNCSESLELE-DPSSG 283


>gi|144953895 nidogen 2 precursor [Homo sapiens]
          Length = 1375

 Score = 59.7 bits (143), Expect = 5e-09
 Identities = 27/63 (42%), Positives = 36/63 (57%), Gaps = 2/63 (3%)

Query: 313  QDPP--CQTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVM 370
            Q PP  C+    N+ +  G      QY+P CD+ G++ P QCHG    CWCVD+ G EV 
Sbjct: 1013 QRPPTICERWRENLLEHYGGTPRDDQYVPQCDDLGHFIPLQCHGKSDFCWCVDKDGREVQ 1072

Query: 371  GSR 373
            G+R
Sbjct: 1073 GTR 1075



 Score = 55.8 bits (133), Expect = 7e-08
 Identities = 22/37 (59%), Positives = 27/37 (72%)

Query: 337 YIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVMGSR 373
           +IP CDE G + P QCHGS G CWCVD  G+EV G++
Sbjct: 959 HIPQCDEQGNFLPLQCHGSTGFCWCVDPDGHEVPGTQ 995


>gi|4507171 secreted protein, acidic, cysteine-rich [Homo sapiens]
          Length = 303

 Score = 58.9 bits (141), Expect = 9e-09
 Identities = 67/297 (22%), Positives = 99/297 (33%), Gaps = 90/297 (30%)

Query: 54  EVGQWNKFRDEVEDDYFRTWSPGKPFDQALDPAKDPCLKMKCSRHKVCIAQDSQTAVCIS 113
           EVG+++   +E E++                 A++PC    C   KVC   ++ T +C+ 
Sbjct: 51  EVGEFDDGAEETEEEVV---------------AENPCQNHHCKHGKVCELDENNTPMCVC 95

Query: 114 HRRLTHRMKEAGVDHRQWRGPILSTCKQCPVVYPSPVCGSDGHTYSFQCKLEYQACVL-- 171
                                   T    P+     VC +D  T+   C      C L  
Sbjct: 96  QD---------------------PTSCPAPIGEFEKVCSNDNKTFDSSCHFFATKCTLEG 134

Query: 172 ---GKQISVKCEGHCPCPSDKPTSTSRNVKRACSDLEFREVANRLRDWFK----ALHESG 224
              G ++ +   G  PC    P          C D E  E   R+RDW K     L+E  
Sbjct: 135 TKKGHKLHLDYIG--PCKYIPP----------CLDSELTEFPLRMRDWLKNVLVTLYERD 182

Query: 225 SQNK-------------------------KTKTLLRPERSRFDTSILPICKDSLGWMFNR 259
             N                            + L R     ++  I P+      W F +
Sbjct: 183 EDNNLLTEKQKLRVKKIHENEKRLEAGDHPVELLARDFEKNYNMYIFPV-----HWQFGQ 237

Query: 260 LDTN-YDLLLDQSELRSIY--LDKNEQCTKAFFNSCDTYKDSLISNNEWCYCFQRQQ 313
           LD +  D  L  +EL  +   L   E CT  FF +CD   D  I+ +EW  CF  +Q
Sbjct: 238 LDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALDEWAGCFGIKQ 294


>gi|55770862 thyroglobulin [Homo sapiens]
          Length = 2768

 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 36/106 (33%), Positives = 45/106 (42%), Gaps = 14/106 (13%)

Query: 318  QTELSNIQKRQ-------GVKKLL--GQYIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNE 368
            Q+ LS  Q+R+       G   LL  G Y+P CD  G ++P QCH   G CWCVD  G  
Sbjct: 999  QSTLSFYQRRRFSPDDSAGASALLRSGPYMPQCDAFGSWEPVQCHAGTGHCWCVDEKGGF 1058

Query: 369  VMGS---RINGVADCAIDFEISGDFASGDFHEWTDDEDDEDDIMND 411
            + GS   R   +  C    E S    SG    W      E+    D
Sbjct: 1059 IPGSLTARSLQIPQCPTTCEKSR--TSGLLSSWKQARSQENPSPKD 1102



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 27/85 (31%), Positives = 38/85 (44%), Gaps = 6/85 (7%)

Query: 300 ISNNEWCYCFQRQQDPPCQTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVGQC 359
           +S N + Y    Q   PC+ +      +Q        Y+P C EDG ++  QC      C
Sbjct: 17  VSANIFEYQVDAQPLRPCELQRETAFLKQA------DYVPQCAEDGSFQTVQCQNDGRSC 70

Query: 360 WCVDRYGNEVMGSRINGVADCAIDF 384
           WCV   G+EV+GSR  G     + F
Sbjct: 71  WCVGANGSEVLGSRQPGRPVACLSF 95



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 22/57 (38%), Positives = 27/57 (47%)

Query: 317 CQTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVMGSR 373
           CQ +   I     +      Y+P C + G Y P QC     QCWCVD  G EV G+R
Sbjct: 96  CQLQKQQILLSGYINSTDTSYLPQCQDSGDYAPVQCDVQQVQCWCVDAEGMEVYGTR 152



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 20/41 (48%), Positives = 25/41 (60%), Gaps = 1/41 (2%)

Query: 337  YIPLCD-EDGYYKPTQCHGSVGQCWCVDRYGNEVMGSRING 376
            Y+P C  EDG + P QC  + G CWCV   G EV G+R+ G
Sbjct: 1165 YVPACRAEDGGFSPVQCDQAQGSCWCVMDSGEEVPGTRVTG 1205



 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 22/59 (37%), Positives = 35/59 (59%), Gaps = 5/59 (8%)

Query: 318 QTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVMGSRING 376
           +T LS+    Q  ++L   ++P C  +G Y+  QC    G+CWCV+ +G E+ GSR+ G
Sbjct: 600 ETVLSSQTCEQTPERL---FVPSCTTEGSYEDVQCFS--GECWCVNSWGKELPGSRVRG 653



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 18/40 (45%), Positives = 24/40 (60%), Gaps = 1/40 (2%)

Query: 337 YIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVMGSRING 376
           Y+P C  +G Y+  QC  + G CWCVD  G E+ G+R  G
Sbjct: 315 YVPSCRRNGDYQAVQCQ-TEGPCWCVDAQGKEMHGTRQQG 353



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 30/109 (27%), Positives = 49/109 (44%), Gaps = 26/109 (23%)

Query: 286 KAFFNSCDT---YKDSLISNNEWCYCFQ-----------RQQDPPCQTELSNIQKRQGVK 331
           + F  SC T   Y+D    + E C+C             R   P C T+    ++R  ++
Sbjct: 614 RLFVPSCTTEGSYEDVQCFSGE-CWCVNSWGKELPGSRVRGGQPRCPTDCE--KQRARMQ 670

Query: 332 KLLGQ-------YIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVMGSR 373
            L+G        ++P C  +G++ P QC  S  +C+CVD  G  + G+R
Sbjct: 671 SLMGSQPAGSTLFVPACTSEGHFLPVQCFNS--ECYCVDAEGQAIPGTR 717


>gi|62243068 insulin-like growth factor binding protein 3 isoform b
           precursor [Homo sapiens]
          Length = 291

 Score = 52.4 bits (124), Expect = 8e-07
 Identities = 28/71 (39%), Positives = 36/71 (50%), Gaps = 7/71 (9%)

Query: 316 PCQTELS---NIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVGQ----CWCVDRYGNE 368
           PC+ E+    N  K   V    G +IP CD+ G+YK  QC  S G+    CWCVD+YG  
Sbjct: 212 PCRREMEDTLNHLKFLNVLSPRGVHIPNCDKKGFYKKKQCRPSKGRKRGFCWCVDKYGQP 271

Query: 369 VMGSRINGVAD 379
           + G    G  D
Sbjct: 272 LPGYTTKGKED 282


>gi|62243248 insulin-like growth factor binding protein 3 isoform a
           precursor [Homo sapiens]
          Length = 297

 Score = 52.4 bits (124), Expect = 8e-07
 Identities = 28/71 (39%), Positives = 36/71 (50%), Gaps = 7/71 (9%)

Query: 316 PCQTELS---NIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVGQ----CWCVDRYGNE 368
           PC+ E+    N  K   V    G +IP CD+ G+YK  QC  S G+    CWCVD+YG  
Sbjct: 218 PCRREMEDTLNHLKFLNVLSPRGVHIPNCDKKGFYKKKQCRPSKGRKRGFCWCVDKYGQP 277

Query: 369 VMGSRINGVAD 379
           + G    G  D
Sbjct: 278 LPGYTTKGKED 288


>gi|11321593 insulin-like growth factor binding protein 6 [Homo
           sapiens]
          Length = 240

 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 27/73 (36%), Positives = 38/73 (52%), Gaps = 8/73 (10%)

Query: 316 PCQTELSNIQKRQGVKKLLGQ---YIPLCDEDGYYKPTQCHGSVGQ----CWCVDRYGNE 368
           PC+  L ++ ++   +   G    Y+P CD  G+Y+  QC  S GQ    CWCVDR G  
Sbjct: 162 PCRRHLDSVLQQLQTEVYRGAQTLYVPNCDHRGFYRKRQCRSSQGQRRGPCWCVDRMGKS 221

Query: 369 VMGSRI-NGVADC 380
           + GS   NG + C
Sbjct: 222 LPGSPDGNGSSSC 234


>gi|54873613 agrin [Homo sapiens]
          Length = 2045

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 33/101 (32%), Positives = 43/101 (42%), Gaps = 29/101 (28%)

Query: 84  DPAKDPCLKMKCSRHKVCIAQDSQTAVCISHRRLTHRMKEAGVDHRQWRGPILSTCKQ-C 142
           D A  PCL ++C+    C  ++ Q A                             C Q C
Sbjct: 462 DQAPSPCLGVQCAFGATCAVKNGQAAC---------------------------ECLQAC 494

Query: 143 PVVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHC 183
             +Y  PVCGSDG TY   C+LE  AC LG++I V  +G C
Sbjct: 495 SSLY-DPVCGSDGVTYGSACELEATACTLGREIQVARKGPC 534



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 36/111 (32%), Positives = 51/111 (45%), Gaps = 28/111 (25%)

Query: 90  CLKMKCSRHKVCIAQDSQTAVCISHRRLTHRMKEAGVDHRQWRGPILSTCKQCPVVYPSP 149
           C +M+C     C+ ++S +A C+                     P+L+    CP    + 
Sbjct: 901 CAEMRCEFGARCV-EESGSAHCVC--------------------PMLT----CPEANATK 935

Query: 150 VCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHCP---CPSDKPTSTSRNV 197
           VCGSDG TY  +C+L+  AC  G QIS++  G C     PS  PTS S  V
Sbjct: 936 VCGSDGVTYGNECQLKTIACRQGLQISIQSLGPCQEAVAPSTHPTSASVTV 986



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 62/282 (21%), Positives = 94/282 (33%), Gaps = 86/282 (30%)

Query: 86  AKDPCLKMKCSRHKVCI-AQDSQTAVCISHRRLTHRMKEAGVDHRQWRGPILSTCKQCPV 144
           ++DPC  + CS    C  + D  TA C+                        +TC+  P 
Sbjct: 244 SRDPCSNVTCSFGSTCARSADGLTASCLCP----------------------ATCRGAP- 280

Query: 145 VYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHC-PCPSDKPTSTSRNVKRACSD 203
                VCGSDG  Y  +C+L  +AC   + +  K +G C PC    P     +  R+C  
Sbjct: 281 --EGTVCGSDGADYPGECQLLRRACARQENVFKKFDGPCDPCQGALP-----DPSRSC-- 331

Query: 204 LEFREVANRLRDWFKALHESGSQNKKTKTLLRPERSRFDTSILPICKD-----SLGWMFN 258
                                 + ++ + LLRPE         P+C D         +  
Sbjct: 332 ------------------RVNPRTRRPEMLLRPESC--PARQAPVCGDDGVTYENDCVMG 371

Query: 259 RLDTNYDLLLDQSELRSIYLDKNEQCTK-AFFNSCDTYKDSLISNNEWCYCFQRQQDPPC 317
           R      LLL   ++RS      +QC +   FN+                C  R+  P C
Sbjct: 372 RSGAARGLLL--QKVRSGQCQGRDQCPEPCRFNA---------------VCLSRRGRPRC 414

Query: 318 QTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVGQC 359
             +              G Y P+C +DG    + C     +C
Sbjct: 415 SCDRVTCD---------GAYRPVCAQDGRTYDSDCWRQQAEC 447



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 21/49 (42%), Positives = 28/49 (57%)

Query: 142 CPVVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHCPCPSDKP 190
           C  V  SPVCGSDG TYS +C+L+   C   + + V  +G C  P+  P
Sbjct: 709 CQSVPGSPVCGSDGVTYSTECELKKARCESQRGLYVAAQGACRGPTFAP 757



 Score = 42.7 bits (99), Expect = 6e-04
 Identities = 20/45 (44%), Positives = 23/45 (51%)

Query: 139 CKQCPVVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHC 183
           C +C    P PVCGSDG TY   C+L   AC+   QI     G C
Sbjct: 620 CPRCEHPPPGPVCGSDGVTYGSACELREAACLQQTQIEEARAGPC 664



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 22/47 (46%), Positives = 24/47 (51%), Gaps = 5/47 (10%)

Query: 142 CP---VVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHCPC 185
           CP   V    PVCGSDGHTY  +C L   AC    QIS+      PC
Sbjct: 555 CPSECVALAQPVCGSDGHTYPSECMLHVHACT--HQISLHVASAGPC 599



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 24/56 (42%), Positives = 32/56 (57%), Gaps = 5/56 (8%)

Query: 139 CKQ--CPVVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHCPCPSDKPTS 192
           CK+  CP V  +PVCGSD  TYS +C+L+   C   ++I +   G  PC S  P S
Sbjct: 197 CKKSPCPSVV-APVCGSDASTYSNECELQRAQCSQQRRIRLLSRG--PCGSRDPCS 249



 Score = 30.8 bits (68), Expect = 2.5
 Identities = 20/66 (30%), Positives = 27/66 (40%), Gaps = 9/66 (13%)

Query: 149 PVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHC-----PCPSDK----PTSTSRNVKR 199
           PVC  DG TY   C  +   C   + I  K +G C     PC   +     T   +N + 
Sbjct: 427 PVCAQDGRTYDSDCWRQQAECRQQRAIPSKHQGPCDQAPSPCLGVQCAFGATCAVKNGQA 486

Query: 200 ACSDLE 205
           AC  L+
Sbjct: 487 ACECLQ 492


>gi|197313714 sparc/osteonectin, cwcv and kazal-like domains
          proteoglycan (testican) 2 isoform 1 [Homo sapiens]
          Length = 77

 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 24/51 (47%), Positives = 33/51 (64%), Gaps = 3/51 (5%)

Query: 21 AAAAAVAAAGGRSDG---GNFLDDKQWLTTISQYDKEVGQWNKFRDEVEDD 68
          AAA A   A G  +G   GNF++D+QWL++ISQY  ++  WN+FRD    D
Sbjct: 18 AAALAEGDAKGLKEGETPGNFMEDEQWLSSISQYSGKIKHWNRFRDVPSSD 68


>gi|10834982 insulin-like growth factor binding protein 5 [Homo
           sapiens]
          Length = 272

 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 25/79 (31%), Positives = 45/79 (56%), Gaps = 8/79 (10%)

Query: 310 QRQQDPPCQTEL-SNIQKRQGVKKLLGQ--YIPLCDEDGYYKPTQCHGSVGQ----CWCV 362
           Q  +  PC+  + +++Q+ +   +++ +  Y+P CD  G+YK  QC  S G+    CWCV
Sbjct: 185 QESEQGPCRRHMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCV 244

Query: 363 DRYGNEVMGSR-INGVADC 380
           D+YG ++ G   ++G   C
Sbjct: 245 DKYGMKLPGMEYVDGDFQC 263


>gi|5901956 follistatin-like 1 precursor [Homo sapiens]
          Length = 308

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 29/86 (33%), Positives = 39/86 (45%), Gaps = 4/86 (4%)

Query: 134 PILSTCKQCPVVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHCPCPSDKPTST 193
           P     +QC   +  PVCGS+G TY   C+L   AC+ G +I V  +GHC        S 
Sbjct: 50  PTCLCIEQCKP-HKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSPSA 108

Query: 194 SRNVKRACSDLEFREVANRLRDWFKA 219
           S  V   C      E+  R+  W +A
Sbjct: 109 SPVV---CYQSNRDELRRRIIQWLEA 131


>gi|24308277 SPARC related modular calcium binding 2 [Homo sapiens]
          Length = 457

 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 18/49 (36%), Positives = 26/49 (53%)

Query: 326 KRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVMGSRI 374
           + Q  K+    +IP C++DG Y   QCH   G CWCV   G  + G+ +
Sbjct: 98  QEQARKEFQQVFIPECNDDGTYSQVQCHSYTGYCWCVTPNGRPISGTAV 146



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 16/25 (64%), Positives = 16/25 (64%)

Query: 338 IPLCDEDGYYKPTQCHGSVGQCWCV 362
           IP C   G YKP QCH S G CWCV
Sbjct: 248 IPECAHGGLYKPVQCHPSTGYCWCV 272


>gi|78190498 secreted modular calcium-binding protein 1 isoform 1
           [Homo sapiens]
          Length = 435

 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 59/256 (23%), Positives = 89/256 (34%), Gaps = 65/256 (25%)

Query: 142 CPVVYPSPVCGSDGHTYSFQCKLEYQAC---VLGKQISVKCE--GHCPCPSDKPTSTSRN 196
           C    P P+C SDG +Y   C+ +   C    LG     +C+  G   C  ++  +  + 
Sbjct: 47  CSRTQPKPICASDGRSYESMCEYQRAKCRDPTLGVVHRGRCKDAGQSKCRLERAQALEQA 106

Query: 197 VK--------RACSDLEFREVANRLRDWF--------KALHESGSQNKKT--------KT 232
            K            D  F +V       +        K +  S  QNK          K 
Sbjct: 107 KKPQEAVFVPECGEDGSFTQVQCHTYTGYCWCVTPDGKPISGSSVQNKTPVCSGSVTDKP 166

Query: 233 LLRPERSRFDTSILPICKDSLGWMFNRLDTNYD------LLLDQSELRSIYLDKNEQCTK 286
           L +    R D    P        +F+  +          L++  S+L +  +  +E+   
Sbjct: 167 LSQGNSGRKDDGSKPTPTMETQPVFDGDEITAPTLWIKHLVIKDSKLNNTNIRNSEKVY- 225

Query: 287 AFFNSCDTYKDSLISNNEWCYCFQRQQDPPCQTELSNIQKRQGVKKLLGQYIPLCDEDGY 346
               SCD  + S +         + QQ+P           R+G+       IP C   G 
Sbjct: 226 ----SCDQERQSALE--------EAQQNP-----------REGI------VIPECAPGGL 256

Query: 347 YKPTQCHGSVGQCWCV 362
           YKP QCH S G CWCV
Sbjct: 257 YKPVQCHQSTGYCWCV 272



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 16/38 (42%), Positives = 21/38 (55%)

Query: 337 YIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVMGSRI 374
           ++P C EDG +   QCH   G CWCV   G  + GS +
Sbjct: 114 FVPECGEDGSFTQVQCHTYTGYCWCVTPDGKPISGSSV 151



 Score = 31.6 bits (70), Expect = 1.5
 Identities = 18/59 (30%), Positives = 32/59 (54%), Gaps = 5/59 (8%)

Query: 255 WMFNRLDTNYDLLLDQSELRSI--YLDKN---EQCTKAFFNSCDTYKDSLISNNEWCYC 308
           W F++LD+N    +++ E++    Y+ K    ++C + F + CD  KD +IS  E   C
Sbjct: 366 WYFSQLDSNSSNDINKREMKPFKRYVKKKAKPKKCARRFTDYCDLNKDKVISLPELKGC 424


>gi|11545873 secreted modular calcium-binding protein 1 isoform 2
           [Homo sapiens]
          Length = 434

 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 59/256 (23%), Positives = 89/256 (34%), Gaps = 65/256 (25%)

Query: 142 CPVVYPSPVCGSDGHTYSFQCKLEYQAC---VLGKQISVKCE--GHCPCPSDKPTSTSRN 196
           C    P P+C SDG +Y   C+ +   C    LG     +C+  G   C  ++  +  + 
Sbjct: 47  CSRTQPKPICASDGRSYESMCEYQRAKCRDPTLGVVHRGRCKDAGQSKCRLERAQALEQA 106

Query: 197 VK--------RACSDLEFREVANRLRDWF--------KALHESGSQNKKT--------KT 232
            K            D  F +V       +        K +  S  QNK          K 
Sbjct: 107 KKPQEAVFVPECGEDGSFTQVQCHTYTGYCWCVTPDGKPISGSSVQNKTPVCSGSVTDKP 166

Query: 233 LLRPERSRFDTSILPICKDSLGWMFNRLDTNYD------LLLDQSELRSIYLDKNEQCTK 286
           L +    R D    P        +F+  +          L++  S+L +  +  +E+   
Sbjct: 167 LSQGNSGRKDDGSKPTPTMETQPVFDGDEITAPTLWIKHLVIKDSKLNNTNIRNSEKVY- 225

Query: 287 AFFNSCDTYKDSLISNNEWCYCFQRQQDPPCQTELSNIQKRQGVKKLLGQYIPLCDEDGY 346
               SCD  + S +         + QQ+P           R+G+       IP C   G 
Sbjct: 226 ----SCDQERQSALE--------EAQQNP-----------REGI------VIPECAPGGL 256

Query: 347 YKPTQCHGSVGQCWCV 362
           YKP QCH S G CWCV
Sbjct: 257 YKPVQCHQSTGYCWCV 272



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 16/38 (42%), Positives = 21/38 (55%)

Query: 337 YIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVMGSRI 374
           ++P C EDG +   QCH   G CWCV   G  + GS +
Sbjct: 114 FVPECGEDGSFTQVQCHTYTGYCWCVTPDGKPISGSSV 151



 Score = 31.6 bits (70), Expect = 1.5
 Identities = 18/59 (30%), Positives = 32/59 (54%), Gaps = 5/59 (8%)

Query: 255 WMFNRLDTNYDLLLDQSELRSI--YLDKN---EQCTKAFFNSCDTYKDSLISNNEWCYC 308
           W F++LD+N    +++ E++    Y+ K    ++C + F + CD  KD +IS  E   C
Sbjct: 366 WYFSQLDSNSSNDINKREMKPFKRYVKKKAKPKKCARRFTDYCDLNKDKVISLPELKGC 424


>gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]
          Length = 1390

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 17/33 (51%), Positives = 28/33 (84%)

Query: 400 DDEDDEDDIMNDEDEIEDDDEDEGDDDDGGDDH 432
           +DEDDEDD  +D+D+ +DDDED+ D++DG +++
Sbjct: 258 EDEDDEDDDDDDDDDDDDDDEDDEDEEDGEEEN 290



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 17/34 (50%), Positives = 26/34 (76%)

Query: 400 DDEDDEDDIMNDEDEIEDDDEDEGDDDDGGDDHD 433
           +D++ EDD  +++DE +DDD+D+ DDDD  DD D
Sbjct: 249 EDQEHEDDGEDEDDEDDDDDDDDDDDDDDEDDED 282



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 18/41 (43%), Positives = 28/41 (68%)

Query: 393 GDFHEWTDDEDDEDDIMNDEDEIEDDDEDEGDDDDGGDDHD 433
           G+  E  DD +DEDD  +D+D+ +DDD+D+ DD+D  D  +
Sbjct: 248 GEDQEHEDDGEDEDDEDDDDDDDDDDDDDDEDDEDEEDGEE 288



 Score = 38.5 bits (88), Expect = 0.012
 Identities = 16/32 (50%), Positives = 21/32 (65%)

Query: 402 EDDEDDIMNDEDEIEDDDEDEGDDDDGGDDHD 433
           E+ ED    D+ E EDD++D+ DDDD  DD D
Sbjct: 246 EEGEDQEHEDDGEDEDDEDDDDDDDDDDDDDD 277



 Score = 36.6 bits (83), Expect = 0.046
 Identities = 16/45 (35%), Positives = 26/45 (57%)

Query: 389 DFASGDFHEWTDDEDDEDDIMNDEDEIEDDDEDEGDDDDGGDDHD 433
           D  + D  E + +  +E +    ED+ ED+D+++ DDDD  DD D
Sbjct: 231 DEETTDNQEGSVESSEEGEDQEHEDDGEDEDDEDDDDDDDDDDDD 275



 Score = 34.7 bits (78), Expect = 0.17
 Identities = 25/107 (23%), Positives = 53/107 (49%), Gaps = 5/107 (4%)

Query: 324 IQKRQGVKKLLGQYIPLCDEDGYYKPTQCHG----SVGQCWCVDRYGNEVMGSRINGVAD 379
           +QK   +KK+  Q +   ++ G +  T+       + G+   + R   E   ++  G  +
Sbjct: 185 LQKMDDMKKMRRQRMRELEDLGVFNETEESNLNMYTRGKQKDIQRTDEETTDNQ-EGSVE 243

Query: 380 CAIDFEISGDFASGDFHEWTDDEDDEDDIMNDEDEIEDDDEDEGDDD 426
            + + E       G+  +  DD+DD+DD  +D+DE ++D+ED  +++
Sbjct: 244 SSEEGEDQEHEDDGEDEDDEDDDDDDDDDDDDDDEDDEDEEDGEEEN 290



 Score = 34.7 bits (78), Expect = 0.17
 Identities = 14/35 (40%), Positives = 27/35 (77%), Gaps = 1/35 (2%)

Query: 394 DFHEWTDDEDDEDDIMNDEDEIEDD-DEDEGDDDD 427
           D  +  D++DD+DD  +D+D+ EDD DE++G++++
Sbjct: 256 DGEDEDDEDDDDDDDDDDDDDDEDDEDEEDGEEEN 290



 Score = 31.2 bits (69), Expect = 1.9
 Identities = 13/40 (32%), Positives = 25/40 (62%)

Query: 383 DFEISGDFASGDFHEWTDDEDDEDDIMNDEDEIEDDDEDE 422
           + E  G+    +  +  DD+DD+DD  +DEDE + ++E++
Sbjct: 252 EHEDDGEDEDDEDDDDDDDDDDDDDDEDDEDEEDGEEENQ 291


>gi|19924161 RPB5-mediating protein isoform b [Homo sapiens]
          Length = 495

 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 26/84 (30%), Positives = 40/84 (47%), Gaps = 26/84 (30%)

Query: 350 TQCHGSVGQCWCVDRYGNEVMGSRINGVADCAIDFEISGDFASGDFHEWTDDEDDEDDIM 409
           T CH  V          +E    ++N   +C+++        S  +H  +DD+DD+DD  
Sbjct: 226 TPCHKDVAS--------SEPFSGQVNSQLNCSVN-------GSSSYH--SDDDDDDDD-- 266

Query: 410 NDEDEIEDDDEDEGDDDDGGDDHD 433
                  DDD+D  DDDDG +DH+
Sbjct: 267 -------DDDDDNIDDDDGDNDHE 283


>gi|19924159 RPB5-mediating protein isoform a [Homo sapiens]
          Length = 535

 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 26/84 (30%), Positives = 40/84 (47%), Gaps = 26/84 (30%)

Query: 350 TQCHGSVGQCWCVDRYGNEVMGSRINGVADCAIDFEISGDFASGDFHEWTDDEDDEDDIM 409
           T CH  V          +E    ++N   +C+++        S  +H  +DD+DD+DD  
Sbjct: 266 TPCHKDVAS--------SEPFSGQVNSQLNCSVN-------GSSSYH--SDDDDDDDD-- 306

Query: 410 NDEDEIEDDDEDEGDDDDGGDDHD 433
                  DDD+D  DDDDG +DH+
Sbjct: 307 -------DDDDDNIDDDDGDNDHE 323


>gi|42740903 MTERF domain containing 2 [Homo sapiens]
          Length = 381

 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 17/34 (50%), Positives = 26/34 (76%)

Query: 400 DDEDDEDDIMNDEDEIEDDDEDEGDDDDGGDDHD 433
           +DEDD+D+  NDED+ ++DD+DE DD+   +D D
Sbjct: 341 EDEDDDDEEDNDEDDNDEDDDDEDDDEAEDNDED 374



 Score = 42.7 bits (99), Expect = 6e-04
 Identities = 23/44 (52%), Positives = 29/44 (65%), Gaps = 1/44 (2%)

Query: 391 ASGDFHEWTDDEDDEDDIMNDEDEI-EDDDEDEGDDDDGGDDHD 433
           AS D  E  DDE+D D+  NDED+  EDDDE E +D+D  DD +
Sbjct: 337 ASLDEDEDDDDEEDNDEDDNDEDDDDEDDDEAEDNDEDEDDDEE 380



 Score = 39.7 bits (91), Expect = 0.005
 Identities = 19/48 (39%), Positives = 29/48 (60%), Gaps = 1/48 (2%)

Query: 387 SGDFASGDFHEWTDDEDDEDDIMNDEDEIEDD-DEDEGDDDDGGDDHD 433
           + D       E  DD+D+ED+  +D DE +DD D+DE +D+D  +D D
Sbjct: 331 TSDDKRASLDEDEDDDDEEDNDEDDNDEDDDDEDDDEAEDNDEDEDDD 378



 Score = 38.9 bits (89), Expect = 0.009
 Identities = 20/45 (44%), Positives = 26/45 (57%)

Query: 383 DFEISGDFASGDFHEWTDDEDDEDDIMNDEDEIEDDDEDEGDDDD 427
           D   S D    D  E  +DEDD D+  +DED+ E +D DE +DDD
Sbjct: 334 DKRASLDEDEDDDDEEDNDEDDNDEDDDDEDDDEAEDNDEDEDDD 378



 Score = 35.8 bits (81), Expect = 0.078
 Identities = 14/23 (60%), Positives = 18/23 (78%)

Query: 400 DDEDDEDDIMNDEDEIEDDDEDE 422
           DD+D++DD   D DE EDDDE+E
Sbjct: 359 DDDDEDDDEAEDNDEDEDDDEEE 381



 Score = 35.0 bits (79), Expect = 0.13
 Identities = 16/51 (31%), Positives = 26/51 (50%)

Query: 383 DFEISGDFASGDFHEWTDDEDDEDDIMNDEDEIEDDDEDEGDDDDGGDDHD 433
           +F++     + +  E      D+     DEDE +DD+ED  +DD+  DD D
Sbjct: 312 EFQVFKKLLAREEEESESSTSDDKRASLDEDEDDDDEEDNDEDDNDEDDDD 362



 Score = 33.5 bits (75), Expect = 0.39
 Identities = 13/37 (35%), Positives = 22/37 (59%)

Query: 397 EWTDDEDDEDDIMNDEDEIEDDDEDEGDDDDGGDDHD 433
           E +  +D    +  DED+ +++D DE D+D+  DD D
Sbjct: 328 ESSTSDDKRASLDEDEDDDDEEDNDEDDNDEDDDDED 364



 Score = 31.6 bits (70), Expect = 1.5
 Identities = 13/29 (44%), Positives = 22/29 (75%), Gaps = 2/29 (6%)

Query: 400 DDEDDEDDIMNDEDEIE--DDDEDEGDDD 426
           +D++DEDD   D+DE E  D+DED+ +++
Sbjct: 353 EDDNDEDDDDEDDDEAEDNDEDEDDDEEE 381



 Score = 31.2 bits (69), Expect = 1.9
 Identities = 14/27 (51%), Positives = 19/27 (70%)

Query: 394 DFHEWTDDEDDEDDIMNDEDEIEDDDE 420
           D  E  DDEDD++   NDEDE +D++E
Sbjct: 355 DNDEDDDDEDDDEAEDNDEDEDDDEEE 381


>gi|55956788 nucleolin [Homo sapiens]
          Length = 710

 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 19/34 (55%), Positives = 26/34 (76%), Gaps = 3/34 (8%)

Query: 400 DDEDDEDDIMNDEDEIEDDDEDEGDDDDGGDDHD 433
           +DED+E+D   DEDE +DDDED+ DDDD  D+ +
Sbjct: 234 EDEDEEED---DEDEDDDDDEDDEDDDDEDDEEE 264



 Score = 38.5 bits (88), Expect = 0.012
 Identities = 17/41 (41%), Positives = 29/41 (70%), Gaps = 2/41 (4%)

Query: 394 DFHEWTDDEDDEDDIMNDEDEIEDDDEDEGDDDDGGDDHDV 434
           D  E  DDED++DD  +DED+ +DDDED+ ++++  ++  V
Sbjct: 235 DEDEEEDDEDEDDD--DDEDDEDDDDEDDEEEEEEEEEEPV 273



 Score = 37.4 bits (85), Expect = 0.027
 Identities = 20/53 (37%), Positives = 27/53 (50%), Gaps = 19/53 (35%)

Query: 400 DDEDDEDDIMNDEDEIE-------------------DDDEDEGDDDDGGDDHD 433
           +DE+D++D   DEDEIE                   DD++DE DDDD  DD +
Sbjct: 155 EDEEDDEDEDEDEDEIEPAAMKAAAAAPASEDEDDEDDEDDEDDDDDEEDDSE 207



 Score = 36.6 bits (83), Expect = 0.046
 Identities = 22/66 (33%), Positives = 31/66 (46%), Gaps = 19/66 (28%)

Query: 387 SGDFASGDFHEWTDDEDDEDDIMNDEDEIEDDDE-------------------DEGDDDD 427
           +G  A  +  +  +D+D E+D  +DEDE ED+DE                   DE D+DD
Sbjct: 136 NGKNAKKEDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAAAAPASEDEDDEDDEDD 195

Query: 428 GGDDHD 433
             DD D
Sbjct: 196 EDDDDD 201



 Score = 35.8 bits (81), Expect = 0.078
 Identities = 25/78 (32%), Positives = 30/78 (38%), Gaps = 35/78 (44%)

Query: 391 ASGDFHEWTDDEDDEDDIMNDEDEIED--------------------------------- 417
           A+    E  DDEDDEDD  +D+DE +D                                 
Sbjct: 179 AAAPASEDEDDEDDEDDEDDDDDEEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDE 238

Query: 418 --DDEDEGDDDDGGDDHD 433
             DDEDE DDDD  D+ D
Sbjct: 239 EEDDEDEDDDDDEDDEDD 256



 Score = 35.8 bits (81), Expect = 0.078
 Identities = 13/37 (35%), Positives = 27/37 (72%)

Query: 391 ASGDFHEWTDDEDDEDDIMNDEDEIEDDDEDEGDDDD 427
           A  +  E  D+++D+DD  +DED+ ++DDE+E ++++
Sbjct: 233 AEDEDEEEDDEDEDDDDDEDDEDDDDEDDEEEEEEEE 269



 Score = 35.4 bits (80), Expect = 0.10
 Identities = 22/61 (36%), Positives = 27/61 (44%), Gaps = 27/61 (44%)

Query: 400 DDEDDEDD--------------------------IMNDEDEIEDD-DEDEGDDDDGGDDH 432
           DD+D+EDD                          +  DEDE EDD DED+ DD+D  DD 
Sbjct: 198 DDDDEEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEEEDDEDEDDDDDEDDEDDD 257

Query: 433 D 433
           D
Sbjct: 258 D 258



 Score = 33.5 bits (75), Expect = 0.39
 Identities = 17/62 (27%), Positives = 31/62 (50%), Gaps = 13/62 (20%)

Query: 385 EISGDFASGDFHEWTDDEDDEDDI-------------MNDEDEIEDDDEDEGDDDDGGDD 431
           E   D +  D  +  D+++DED+I               DED+ +D+D+++ DDD+  D 
Sbjct: 147 EEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAAAAPASEDEDDEDDEDDEDDDDDEEDDS 206

Query: 432 HD 433
            +
Sbjct: 207 EE 208


>gi|5453652 follistatin isoform FST317 precursor [Homo sapiens]
          Length = 317

 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 25/97 (25%), Positives = 37/97 (38%), Gaps = 22/97 (22%)

Query: 87  KDPCLKMKCSRHKVCIAQDSQTAVCISHRRLTHRMKEAGVDHRQWRGPILSTCKQCPVVY 146
           K  C  + C     C+   +  A C++  R+                     C + P   
Sbjct: 165 KKTCRDVFCPGSSTCVVDQTNNAYCVTCNRI---------------------CPE-PASS 202

Query: 147 PSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHC 183
              +CG+DG TYS  C L    C+LG+ I +  EG C
Sbjct: 203 EQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKC 239



 Score = 37.4 bits (85), Expect = 0.027
 Identities = 18/50 (36%), Positives = 24/50 (48%), Gaps = 5/50 (10%)

Query: 139 CKQCPVVYPS-----PVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHC 183
           C  C  + P      PVC SD  TY+ +C ++  AC  G  + VK  G C
Sbjct: 267 CSLCDELCPDSKSDEPVCASDNATYASECAMKEAACSSGVLLEVKHSGSC 316



 Score = 35.0 bits (79), Expect = 0.13
 Identities = 14/40 (35%), Positives = 21/40 (52%)

Query: 144 VVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHC 183
           + +  PVCG DG TY  +C L    C    ++ V+ +G C
Sbjct: 125 ITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQYQGRC 164


>gi|7242222 follistatin isoform FST344 precursor [Homo sapiens]
          Length = 344

 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 25/97 (25%), Positives = 37/97 (38%), Gaps = 22/97 (22%)

Query: 87  KDPCLKMKCSRHKVCIAQDSQTAVCISHRRLTHRMKEAGVDHRQWRGPILSTCKQCPVVY 146
           K  C  + C     C+   +  A C++  R+                     C + P   
Sbjct: 165 KKTCRDVFCPGSSTCVVDQTNNAYCVTCNRI---------------------CPE-PASS 202

Query: 147 PSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHC 183
              +CG+DG TYS  C L    C+LG+ I +  EG C
Sbjct: 203 EQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKC 239



 Score = 37.4 bits (85), Expect = 0.027
 Identities = 18/50 (36%), Positives = 24/50 (48%), Gaps = 5/50 (10%)

Query: 139 CKQCPVVYPS-----PVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHC 183
           C  C  + P      PVC SD  TY+ +C ++  AC  G  + VK  G C
Sbjct: 267 CSLCDELCPDSKSDEPVCASDNATYASECAMKEAACSSGVLLEVKHSGSC 316



 Score = 35.0 bits (79), Expect = 0.13
 Identities = 14/40 (35%), Positives = 21/40 (52%)

Query: 144 VVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHC 183
           + +  PVCG DG TY  +C L    C    ++ V+ +G C
Sbjct: 125 ITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQYQGRC 164


>gi|4504615 insulin-like growth factor binding protein 1 precursor
           [Homo sapiens]
          Length = 259

 Score = 42.7 bits (99), Expect = 6e-04
 Identities = 27/84 (32%), Positives = 42/84 (50%), Gaps = 14/84 (16%)

Query: 316 PCQTELSNI-------QKRQGVKKLLGQYIPLCDEDGYYKPTQCH----GSVGQCWCVDR 364
           PC+ EL  +       Q+  G +++   Y+P C+++G+Y   QC     G  G CWCV  
Sbjct: 175 PCRIELYRVVESLAKAQETSG-EEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYP 233

Query: 365 Y-GNEVMGS-RINGVADCAIDFEI 386
           + G  + GS  I G  +C I F +
Sbjct: 234 WNGKRIPGSPEIRGDPNCQIYFNV 257


>gi|54792136 follistatin-like 4 [Homo sapiens]
          Length = 842

 Score = 42.7 bits (99), Expect = 6e-04
 Identities = 21/43 (48%), Positives = 24/43 (55%)

Query: 149 PVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHCPCPSDKPT 191
           PVCGSDG  Y   CKL   AC+LGK+I+V     C    D  T
Sbjct: 99  PVCGSDGRFYENHCKLHRAACLLGKRITVIHSKDCFLKGDTCT 141


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.135    0.441 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,144,600
Number of Sequences: 37866
Number of extensions: 951591
Number of successful extensions: 11751
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 237
Number of HSP's successfully gapped in prelim test: 89
Number of HSP's that attempted gapping in prelim test: 6787
Number of HSP's gapped (non-prelim): 2699
length of query: 436
length of database: 18,247,518
effective HSP length: 105
effective length of query: 331
effective length of database: 14,271,588
effective search space: 4723895628
effective search space used: 4723895628
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.