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Search of human proteins with 91206456
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|91206456 hypothetical protein LOC257415 isoform 1 [Homo
sapiens]
(247 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|91206456 hypothetical protein LOC257415 isoform 1 [Homo sapiens] 481 e-136
gi|91206454 hypothetical protein LOC257415 isoform 2 [Homo sapiens] 460 e-130
gi|27734775 hypothetical protein LOC286499 [Homo sapiens] 379 e-105
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 79 4e-15
gi|4557509 cylicin 2 [Homo sapiens] 77 1e-14
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ... 76 2e-14
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [... 76 2e-14
gi|168229156 NFKB activating protein [Homo sapiens] 76 3e-14
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 75 4e-14
gi|156104889 myeloid/lymphoid or mixed-lineage leukemia (trithor... 75 4e-14
gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens] 74 9e-14
gi|239508778 PREDICTED: hypothetical protein, partial [Homo sapi... 72 3e-13
gi|40068059 CBF1 interacting corepressor [Homo sapiens] 71 8e-13
gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1... 71 8e-13
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 70 2e-12
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 70 2e-12
gi|52426743 cisplatin resistance-associated overexpressed protei... 70 2e-12
gi|19923485 cisplatin resistance-associated overexpressed protei... 70 2e-12
gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain ... 67 1e-11
gi|42560244 peptidylprolyl isomerase G [Homo sapiens] 67 1e-11
gi|4759100 splicing factor, arginine/serine-rich 11 [Homo sapiens] 67 2e-11
gi|117553580 adaptor-related protein complex 3, delta 1 subunit ... 66 3e-11
gi|151301228 formin binding protein 3 [Homo sapiens] 66 3e-11
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 65 4e-11
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] 65 4e-11
gi|221219020 NYD-SP11 protein [Homo sapiens] 65 5e-11
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 64 9e-11
gi|56090620 NFKB activating protein-like [Homo sapiens] 64 9e-11
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 64 1e-10
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 64 2e-10
>gi|91206456 hypothetical protein LOC257415 isoform 1 [Homo sapiens]
Length = 247
Score = 481 bits (1237), Expect = e-136
Identities = 247/247 (100%), Positives = 247/247 (100%)
Query: 1 MGKRDNRVAYMNPIAMARSRGPIQSSGPTIQDYLNRPRPTWEEVKEQLEKKKKGSKALAE 60
MGKRDNRVAYMNPIAMARSRGPIQSSGPTIQDYLNRPRPTWEEVKEQLEKKKKGSKALAE
Sbjct: 1 MGKRDNRVAYMNPIAMARSRGPIQSSGPTIQDYLNRPRPTWEEVKEQLEKKKKGSKALAE 60
Query: 61 FEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSD 120
FEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSD
Sbjct: 61 FEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSD 120
Query: 121 SEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKK 180
SEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKK
Sbjct: 121 SEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKK 180
Query: 181 RKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAA 240
RKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAA
Sbjct: 181 RKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAA 240
Query: 241 SSSPDSP 247
SSSPDSP
Sbjct: 241 SSSPDSP 247
>gi|91206454 hypothetical protein LOC257415 isoform 2 [Homo sapiens]
Length = 237
Score = 460 bits (1184), Expect = e-130
Identities = 237/237 (100%), Positives = 237/237 (100%)
Query: 11 MNPIAMARSRGPIQSSGPTIQDYLNRPRPTWEEVKEQLEKKKKGSKALAEFEEKMNENWK 70
MNPIAMARSRGPIQSSGPTIQDYLNRPRPTWEEVKEQLEKKKKGSKALAEFEEKMNENWK
Sbjct: 1 MNPIAMARSRGPIQSSGPTIQDYLNRPRPTWEEVKEQLEKKKKGSKALAEFEEKMNENWK 60
Query: 71 KELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGK 130
KELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGK
Sbjct: 61 KELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGK 120
Query: 131 RRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPL 190
RRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPL
Sbjct: 121 RRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPL 180
Query: 191 SSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSSPDSP 247
SSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSSPDSP
Sbjct: 181 SSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSSPDSP 237
>gi|27734775 hypothetical protein LOC286499 [Homo sapiens]
Length = 248
Score = 379 bits (974), Expect = e-105
Identities = 201/245 (82%), Positives = 220/245 (89%), Gaps = 4/245 (1%)
Query: 1 MGKRDNRVAYMNPIAMARSRGPIQSSGPTIQDYLNRPRPTWEEVKEQLEKKKKGSKALAE 60
MGKRDNRVAYMNPIAMAR RGP QS GPTIQDYLNRPRPTWEEVK+QLE KK GSKALAE
Sbjct: 1 MGKRDNRVAYMNPIAMARWRGPTQSVGPTIQDYLNRPRPTWEEVKKQLENKKTGSKALAE 60
Query: 61 FEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSD 120
FEEKMNENWKKELEK REKLLSG+ESSSKKR+RKKK KKKS R SSSSSSSSDSSSSSSD
Sbjct: 61 FEEKMNENWKKELEKSREKLLSGNESSSKKRERKKKRKKKSCR-SSSSSSSSDSSSSSSD 119
Query: 121 SEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKK 180
SEDE+KKQGKRRKKKKNRS+KSS+SS E+ES+SK+S+KKKKKSKD TEKEKD++ LSKK
Sbjct: 120 SEDEEKKQGKRRKKKKNRSYKSSQSSTHESESESKESVKKKKKSKDETEKEKDVRSLSKK 179
Query: 181 R-KMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKK--HKKHSKKKKK 237
R K Y +DKPLSSES SES+Y E+V+AKKK+ EERE+A EK KKKKK HKKHSKKKKK
Sbjct: 180 RKKSYPDDKPLSSESSSESDYEEDVQAKKKRRCEEREQAKEKVKKKKKKQHKKHSKKKKK 239
Query: 238 KAASS 242
K+ SS
Sbjct: 240 KSGSS 244
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 79.0 bits (193), Expect = 4e-15
Identities = 56/213 (26%), Positives = 106/213 (49%), Gaps = 19/213 (8%)
Query: 33 YLNRP--RPTWE-EVKE---QLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSES 86
++++P +P W+ E++E ++E +K+G K E E K +++ ++ REK
Sbjct: 24 HISKPCTQPGWQSEIREREREIETRKEGKKE-RESERKKERREREKRKREREK------- 75
Query: 87 SSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESS 146
+KR+R KKEKK G + E E+K++ K +K+KK R S E
Sbjct: 76 -ERKRERGKKEKK--GERKKEERERKKRRREKENKEGEEKEKRK-KKEKKERGRTSKEGK 131
Query: 147 MSETESDSK-DSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVR 205
E + + K + K++++ K+ EKE++ K K+ + +K + E + R
Sbjct: 132 ERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRER 191
Query: 206 AKKKKSSEEREKATEKTKKKKKHKKHSKKKKKK 238
+K++ E K + KK++K K+ KK+++K
Sbjct: 192 NRKERKKERERKERRERKKERKKKEERKKERQK 224
Score = 70.1 bits (170), Expect = 2e-12
Identities = 50/211 (23%), Positives = 96/211 (45%), Gaps = 37/211 (17%)
Query: 36 RPRPTWEEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKK 95
R R + +E+ K+++G K EK E K+E E+ + + ++ +K +RKK
Sbjct: 64 REREKRKREREKERKRERGKK------EKKGERKKEERERKKRRREKENKEGEEKEKRKK 117
Query: 96 KEKKKSGRYSSSSSSSSDSSSSSSDS--------EDEDKKQGKRRKKKKNRSHKSSESSM 147
KEKK+ GR S + E+ +K++ ++ +KK+ R +
Sbjct: 118 KEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRER------KQV 171
Query: 148 SETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAK 207
E E + K+ +K++K ++ KE+ KK + E + E R K
Sbjct: 172 GEKEEERKEKERKERKKRERNRKER------KKERERKERRERKKE-----------RKK 214
Query: 208 KKKSSEEREKATEKTKKKKKHKKHSKKKKKK 238
K++ +ER+K + ++K+ K +K++KK
Sbjct: 215 KEERKKERQKDRQTNWREKERGKRERKERKK 245
Score = 60.8 bits (146), Expect = 1e-09
Identities = 36/177 (20%), Positives = 85/177 (48%), Gaps = 33/177 (18%)
Query: 69 WKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQ 128
W+ E+ + ++ + E ++ +KKE++ + E +++
Sbjct: 34 WQSEIREREREIETRKEGKKERESERKKERR--------------------EREKRKRER 73
Query: 129 GKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDK 188
K RK+++ + K E E E + +++K++K+G EKEK ++K +++
Sbjct: 74 EKERKRERGKKEKKGERKKEERERKKR---RREKENKEGEEKEK-------RKKKEKKER 123
Query: 189 PLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSSPD 245
+S+ E E EE +K++ +ERE+ E+ +K+++ K+ K+++K+ +
Sbjct: 124 GRTSKEGKERERKEE---RKREERKERERKKEEREKERERKERKKRERKQVGEKEEE 177
>gi|4557509 cylicin 2 [Homo sapiens]
Length = 348
Score = 77.4 bits (189), Expect = 1e-14
Identities = 61/205 (29%), Positives = 95/205 (46%), Gaps = 9/205 (4%)
Query: 43 EVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRK---KKEKK 99
E+K+ + KKG EEK++ KK+ +K ++ G +S+++ K KK+ K
Sbjct: 133 ELKQGKKDSKKGKDIEKGKEEKLDA--KKDSKKGKKDAEKGKDSATESEDEKGGAKKDNK 190
Query: 100 KSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSET--ESDSKDS 157
K + S+ S+ S ++D K+GK+ KK S ++ ++ + D K
Sbjct: 191 KDKKDSNKGKDSATESEGEKGGTEKDSKKGKKDSKKGKDSAIELQAVKADEKKDEDGKKD 250
Query: 158 LKKKKKSKDGTEKEKDI-KGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKK-KKSSEER 215
K +SKD + K+I KG K+K S D + ES+ AKK K E+
Sbjct: 251 ANKGDESKDAKKDAKEIKKGKKDKKKPSSTDSDSKDDVKKESKKDATKDAKKVAKKDTEK 310
Query: 216 EKATEKTKKKKKHKKHSKKKKKKAA 240
E A K KK KK +KK KK A
Sbjct: 311 ESADSKKDAKKNAKKDAKKDAKKNA 335
Score = 73.6 bits (179), Expect = 2e-13
Identities = 58/214 (27%), Positives = 91/214 (42%), Gaps = 8/214 (3%)
Query: 36 RPRPTWEEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKK 95
+P T E + E KKG + + +E+ K+ +K +K + K ++ K
Sbjct: 100 KPTRTVEVDSKAAEIGKKGEDKTTQKDTTDSESELKQGKKDSKK----GKDIEKGKEEKL 155
Query: 96 KEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSE---TES 152
KK S + + DS++ S D + KK K+ KK N+ S+ S E TE
Sbjct: 156 DAKKDSKKGKKDAEKGKDSATESEDEKGGAKKDNKKDKKDSNKGKDSATESEGEKGGTEK 215
Query: 153 DSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEV-RAKKKKS 211
DSK K KK KD + + +K KK + +D ES + +E+ + KK K
Sbjct: 216 DSKKGKKDSKKGKDSAIELQAVKADEKKDEDGKKDANKGDESKDAKKDAKEIKKGKKDKK 275
Query: 212 SEEREKATEKTKKKKKHKKHSKKKKKKAASSSPD 245
+ K KK+ KK + K KK A +
Sbjct: 276 KPSSTDSDSKDDVKKESKKDATKDAKKVAKKDTE 309
Score = 51.6 bits (122), Expect = 6e-07
Identities = 53/184 (28%), Positives = 75/184 (40%), Gaps = 40/184 (21%)
Query: 94 KKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESD 153
K E K G ++ ++DS S + KQGK+ KK K E + + + D
Sbjct: 110 KAAEIGKKGEDKTTQKDTTDSES--------ELKQGKKDSKKGKDIEKGKEEKL-DAKKD 160
Query: 154 SKDSLKKKKKSKDGTEKEKDIKGLSKK-RKMYSEDKPLSSESLSESEYIE---EVRAKKK 209
SK K +K KD + +D KG +KK K +D +S +ESE + E +KK
Sbjct: 161 SKKGKKDAEKGKDSATESEDEKGGAKKDNKKDKKDSNKGKDSATESEGEKGGTEKDSKKG 220
Query: 210 KSSEER----------EKATEK-----------------TKKKKKHKKHSKKKKKKAASS 242
K ++ KA EK KK K K KK KKK +S+
Sbjct: 221 KKDSKKGKDSAIELQAVKADEKKDEDGKKDANKGDESKDAKKDAKEIKKGKKDKKKPSST 280
Query: 243 SPDS 246
DS
Sbjct: 281 DSDS 284
Score = 47.8 bits (112), Expect = 9e-06
Identities = 43/154 (27%), Positives = 74/154 (48%), Gaps = 32/154 (20%)
Query: 40 TWEEVKEQLEKKKKGSKALAEFE-----EKMNENWKKELEKHREKLLSGSESSSKKRQRK 94
T ++ K+ + KKG + E + EK +E+ KK+ K E ++ +K+ ++
Sbjct: 213 TEKDSKKGKKDSKKGKDSAIELQAVKADEKKDEDGKKDANKGDES--KDAKKDAKEIKKG 270
Query: 95 KKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKR--RKKKKNRSHKSSESSMSETES 152
KK+KKK SS+ SDS+D+ KK+ K+ K K + K +E ++++
Sbjct: 271 KKDKKKP-------------SSTDSDSKDDVKKESKKDATKDAKKVAKKDTEKESADSKK 317
Query: 153 DSKDSLKK-------KKKSKDGTEKEKDIKGLSK 179
D+K + KK K KD ++KD K K
Sbjct: 318 DAKKNAKKDAKKDAKKNAKKD---EKKDAKKKGK 348
>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
[Homo sapiens]
Length = 624
Score = 76.3 bits (186), Expect = 2e-14
Identities = 56/218 (25%), Positives = 107/218 (49%), Gaps = 13/218 (5%)
Query: 37 PRPTWEEVKEQLEKKKKGSKAL-AEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKK 95
P+ +E++E +++ ++ + A E + ++ +++ + R S S SSSK R+K
Sbjct: 268 PQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRK 327
Query: 96 KEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSK 155
+ + K S + S S S S + + + + R+K ++RSH + + + K
Sbjct: 328 RSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEK 387
Query: 156 DSLKKKKKSKD-----GTEKEKDIKGLSKKR-----KMYSEDKPLSSESLSESEYIEEVR 205
+ +K+K + K+ EKEK+ +G +K R K +DK E E E+ E+ R
Sbjct: 388 ERVKEKDREKEREREKEREKEKE-RGKNKDRDKEREKDREKDKEKDREREREKEH-EKDR 445
Query: 206 AKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSS 243
K+K+ +++EK EK + K+ +K K KK + S
Sbjct: 446 DKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRS 483
Score = 66.2 bits (160), Expect = 2e-11
Identities = 45/211 (21%), Positives = 92/211 (43%), Gaps = 6/211 (2%)
Query: 35 NRPRPTWEEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRK 94
+R R K ++++ S++ + +K + +K EK R K + K+R+R+
Sbjct: 347 DRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVK----EKDREKERERE 402
Query: 95 KKEKKKSGRYSSSSSSSSDSSSSSSDSE-DEDKKQGKRRKKKKNRSHKSSESSMSETESD 153
K+ +K+ R + D E D ++++ K +K +++ + + E E D
Sbjct: 403 KEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKD 462
Query: 154 -SKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSS 212
SK+ +K+KK K + + R E + S S S S + +K S
Sbjct: 463 RSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRS 522
Query: 213 EEREKATEKTKKKKKHKKHSKKKKKKAASSS 243
+K KK++K + H +++++ S+S
Sbjct: 523 PSPRSRNKKDKKREKERDHISERRERERSTS 553
Score = 63.2 bits (152), Expect = 2e-10
Identities = 49/239 (20%), Positives = 106/239 (44%), Gaps = 13/239 (5%)
Query: 18 RSRGPIQSSGPTIQDYLNRPRPTWEEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHR 77
RS+ P + + + +R R + ++ +K K + + E + + +KE EK +
Sbjct: 350 RSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEK 409
Query: 78 EKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQ--------- 128
E+ + +++ R+K +K+K D +D++K++
Sbjct: 410 ERGKNKDRDKEREKDREK-DKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEID 468
Query: 129 GKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEK-EKDIKGLSKKRKMYSED 187
KR+K KK+R+ S ++ + S S++ +++ +S + + K IK S +
Sbjct: 469 EKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSR 528
Query: 188 KPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSSPDS 246
+ E ++I E R +++ +S K++ K+K +K+S K+K + PDS
Sbjct: 529 NKKDKKREKERDHISERRERERSTS--MRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDS 585
Score = 61.2 bits (147), Expect = 8e-10
Identities = 47/204 (23%), Positives = 86/204 (42%), Gaps = 12/204 (5%)
Query: 35 NRPRPTWEEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRK 94
NR R ++ + KK SK+ + + + + + + REK+ K R+ K
Sbjct: 339 NRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDRE-K 397
Query: 95 KKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDS 154
++E++K + D ++DK++ + R+++K H+ E E D
Sbjct: 398 EREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKE--HEKDRDKEKEKEQD- 454
Query: 155 KDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEE 214
K+K++ KD KE D K +K+ S P S + S R +++ S
Sbjct: 455 ----KEKEREKD-RSKEIDEK---RKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSS 506
Query: 215 REKATEKTKKKKKHKKHSKKKKKK 238
R T KT K+K + S + + K
Sbjct: 507 RSPRTSKTIKRKSSRSPSPRSRNK 530
Score = 59.3 bits (142), Expect = 3e-09
Identities = 41/200 (20%), Positives = 86/200 (43%), Gaps = 11/200 (5%)
Query: 45 KEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRY 104
K +K+ SK + N + +K R + S + SK R+R+K + R
Sbjct: 321 KSHSRRKRSQSK-----HRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRD 375
Query: 105 SSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKS 164
+ +D +K++ + ++++K + ++ E E D + +K ++
Sbjct: 376 KRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRER 435
Query: 165 KDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKK 224
+ E EKD K K +DK E S+ I+E R KK K S ++ +++
Sbjct: 436 EREKEHEKD----RDKEKEKEQDKEKEREK-DRSKEIDEKR-KKDKKSRTPPRSYNASRR 489
Query: 225 KKKHKKHSKKKKKKAASSSP 244
+ + ++++ +++S SP
Sbjct: 490 SRSSSRERRRRRSRSSSRSP 509
Score = 57.0 bits (136), Expect = 1e-08
Identities = 56/228 (24%), Positives = 100/228 (43%), Gaps = 20/228 (8%)
Query: 35 NRPRPTWEEVKEQLEKKKKGSKALAEFE---EKMNENWK-KELEKHREKLLSGSESSSKK 90
++ + T E++KE+ K+K + E E EK E K K+ +K REK + ++
Sbjct: 375 DKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRE 434
Query: 91 RQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSET 150
R+R+K+ +K + E ++K R+K KK+R+ S ++ +
Sbjct: 435 REREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEK----RKKDKKSRTPPRSYNASRRS 490
Query: 151 ESDSKDSLKKKKKSKDGTEK-EKDIKGLSKK----RKMYSEDKPLSSESLSESEYIEEVR 205
S S++ +++ +S + + K IK S + R +DK E SE E R
Sbjct: 491 RSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERER 550
Query: 206 AKK-KKSSEEREKATEKTK-----KKKKHKKHSKKKKKKAASSSPDSP 247
+ +KSS +R+ + K K+K+H K K D+P
Sbjct: 551 STSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDK-DAP 597
Score = 53.9 bits (128), Expect = 1e-07
Identities = 41/156 (26%), Positives = 70/156 (44%), Gaps = 4/156 (2%)
Query: 42 EEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSK-KRQRKKKEKKK 100
E+ KEQ ++K++ E +EK ++ K S SSS+ +R+R+ + +
Sbjct: 448 EKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSR 507
Query: 101 SGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSM--SETESDSKDSL 158
S R S + S S S +DKK+ K R R + +SM S + D K+ L
Sbjct: 508 SPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKL 567
Query: 159 KKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSES 194
+K S E K+ S +++ +D P + E+
Sbjct: 568 EKNSTSLKEKEHNKE-PDSSVSKEVDDKDAPRTEEN 602
Score = 33.9 bits (76), Expect = 0.13
Identities = 22/88 (25%), Positives = 42/88 (47%), Gaps = 1/88 (1%)
Query: 62 EEKMNENWKKELEKHREKLLSGS-ESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSD 120
++K E + + + RE+ S S SS R K+K +K S + SS S +
Sbjct: 531 KDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKE 590
Query: 121 SEDEDKKQGKRRKKKKNRSHKSSESSMS 148
+D+D + + K + N + + +E ++S
Sbjct: 591 VDDKDAPRTEENKIQHNGNCQLNEENLS 618
>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b
[Homo sapiens]
Length = 508
Score = 76.3 bits (186), Expect = 2e-14
Identities = 56/218 (25%), Positives = 107/218 (49%), Gaps = 13/218 (5%)
Query: 37 PRPTWEEVKEQLEKKKKGSKAL-AEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKK 95
P+ +E++E +++ ++ + A E + ++ +++ + R S S SSSK R+K
Sbjct: 152 PQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRK 211
Query: 96 KEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSK 155
+ + K S + S S S S + + + + R+K ++RSH + + + K
Sbjct: 212 RSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEK 271
Query: 156 DSLKKKKKSKD-----GTEKEKDIKGLSKKR-----KMYSEDKPLSSESLSESEYIEEVR 205
+ +K+K + K+ EKEK+ +G +K R K +DK E E E+ E+ R
Sbjct: 272 ERVKEKDREKEREREKEREKEKE-RGKNKDRDKEREKDREKDKEKDREREREKEH-EKDR 329
Query: 206 AKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSS 243
K+K+ +++EK EK + K+ +K K KK + S
Sbjct: 330 DKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRS 367
Score = 66.2 bits (160), Expect = 2e-11
Identities = 45/211 (21%), Positives = 92/211 (43%), Gaps = 6/211 (2%)
Query: 35 NRPRPTWEEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRK 94
+R R K ++++ S++ + +K + +K EK R K + K+R+R+
Sbjct: 231 DRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVK----EKDREKERERE 286
Query: 95 KKEKKKSGRYSSSSSSSSDSSSSSSDSE-DEDKKQGKRRKKKKNRSHKSSESSMSETESD 153
K+ +K+ R + D E D ++++ K +K +++ + + E E D
Sbjct: 287 KEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKD 346
Query: 154 -SKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSS 212
SK+ +K+KK K + + R E + S S S S + +K S
Sbjct: 347 RSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRS 406
Query: 213 EEREKATEKTKKKKKHKKHSKKKKKKAASSS 243
+K KK++K + H +++++ S+S
Sbjct: 407 PSPRSRNKKDKKREKERDHISERRERERSTS 437
Score = 63.2 bits (152), Expect = 2e-10
Identities = 49/239 (20%), Positives = 106/239 (44%), Gaps = 13/239 (5%)
Query: 18 RSRGPIQSSGPTIQDYLNRPRPTWEEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHR 77
RS+ P + + + +R R + ++ +K K + + E + + +KE EK +
Sbjct: 234 RSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEK 293
Query: 78 EKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQ--------- 128
E+ + +++ R+K +K+K D +D++K++
Sbjct: 294 ERGKNKDRDKEREKDREK-DKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEID 352
Query: 129 GKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEK-EKDIKGLSKKRKMYSED 187
KR+K KK+R+ S ++ + S S++ +++ +S + + K IK S +
Sbjct: 353 EKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSR 412
Query: 188 KPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSSPDS 246
+ E ++I E R +++ +S K++ K+K +K+S K+K + PDS
Sbjct: 413 NKKDKKREKERDHISERRERERSTS--MRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDS 469
Score = 61.2 bits (147), Expect = 8e-10
Identities = 47/204 (23%), Positives = 86/204 (42%), Gaps = 12/204 (5%)
Query: 35 NRPRPTWEEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRK 94
NR R ++ + KK SK+ + + + + + + REK+ K R+ K
Sbjct: 223 NRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDRE-K 281
Query: 95 KKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDS 154
++E++K + D ++DK++ + R+++K H+ E E D
Sbjct: 282 EREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKE--HEKDRDKEKEKEQD- 338
Query: 155 KDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEE 214
K+K++ KD KE D K +K+ S P S + S R +++ S
Sbjct: 339 ----KEKEREKD-RSKEIDEK---RKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSS 390
Query: 215 REKATEKTKKKKKHKKHSKKKKKK 238
R T KT K+K + S + + K
Sbjct: 391 RSPRTSKTIKRKSSRSPSPRSRNK 414
Score = 59.3 bits (142), Expect = 3e-09
Identities = 41/200 (20%), Positives = 86/200 (43%), Gaps = 11/200 (5%)
Query: 45 KEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRY 104
K +K+ SK + N + +K R + S + SK R+R+K + R
Sbjct: 205 KSHSRRKRSQSK-----HRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRD 259
Query: 105 SSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKS 164
+ +D +K++ + ++++K + ++ E E D + +K ++
Sbjct: 260 KRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRER 319
Query: 165 KDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKK 224
+ E EKD K K +DK E S+ I+E R KK K S ++ +++
Sbjct: 320 EREKEHEKD----RDKEKEKEQDKEKEREK-DRSKEIDEKR-KKDKKSRTPPRSYNASRR 373
Query: 225 KKKHKKHSKKKKKKAASSSP 244
+ + ++++ +++S SP
Sbjct: 374 SRSSSRERRRRRSRSSSRSP 393
Score = 57.0 bits (136), Expect = 1e-08
Identities = 56/228 (24%), Positives = 100/228 (43%), Gaps = 20/228 (8%)
Query: 35 NRPRPTWEEVKEQLEKKKKGSKALAEFE---EKMNENWK-KELEKHREKLLSGSESSSKK 90
++ + T E++KE+ K+K + E E EK E K K+ +K REK + ++
Sbjct: 259 DKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRE 318
Query: 91 RQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSET 150
R+R+K+ +K + E ++K R+K KK+R+ S ++ +
Sbjct: 319 REREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEK----RKKDKKSRTPPRSYNASRRS 374
Query: 151 ESDSKDSLKKKKKSKDGTEK-EKDIKGLSKK----RKMYSEDKPLSSESLSESEYIEEVR 205
S S++ +++ +S + + K IK S + R +DK E SE E R
Sbjct: 375 RSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERER 434
Query: 206 AKK-KKSSEEREKATEKTK-----KKKKHKKHSKKKKKKAASSSPDSP 247
+ +KSS +R+ + K K+K+H K K D+P
Sbjct: 435 STSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDK-DAP 481
Score = 53.9 bits (128), Expect = 1e-07
Identities = 41/156 (26%), Positives = 70/156 (44%), Gaps = 4/156 (2%)
Query: 42 EEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSK-KRQRKKKEKKK 100
E+ KEQ ++K++ E +EK ++ K S SSS+ +R+R+ + +
Sbjct: 332 EKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSR 391
Query: 101 SGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSM--SETESDSKDSL 158
S R S + S S S +DKK+ K R R + +SM S + D K+ L
Sbjct: 392 SPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKL 451
Query: 159 KKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSES 194
+K S E K+ S +++ +D P + E+
Sbjct: 452 EKNSTSLKEKEHNKE-PDSSVSKEVDDKDAPRTEEN 486
Score = 33.9 bits (76), Expect = 0.13
Identities = 22/88 (25%), Positives = 42/88 (47%), Gaps = 1/88 (1%)
Query: 62 EEKMNENWKKELEKHREKLLSGS-ESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSD 120
++K E + + + RE+ S S SS R K+K +K S + SS S +
Sbjct: 415 KDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKE 474
Query: 121 SEDEDKKQGKRRKKKKNRSHKSSESSMS 148
+D+D + + K + N + + +E ++S
Sbjct: 475 VDDKDAPRTEENKIQHNGNCQLNEENLS 502
>gi|168229156 NFKB activating protein [Homo sapiens]
Length = 415
Score = 75.9 bits (185), Expect = 3e-14
Identities = 62/218 (28%), Positives = 107/218 (49%), Gaps = 38/218 (17%)
Query: 62 EEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDS 121
E K + E+ ++K S S+ SKKR++KK K+K +YS S S SDS + SSD
Sbjct: 167 EPKKSTTSASTSEEEKKKKSSRSKERSKKRRKKKSSKRKHKKYSEDSDSDSDSETDSSDE 226
Query: 122 EDE--DKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKS-------KDGTEKEK 172
+++ KK K+ KKKK+RS K + ++ +S DS K+ + KD T+ E+
Sbjct: 227 DNKRRAKKAKKKEKKKKHRSKKYKKKRSKKSRKESSDSSSKESQEEFLENPWKDRTKAEE 286
Query: 173 --DIKGLSKKRKMYS-EDKPLS-------SESLSESEYIEEVRAKKKK-----SSEE--- 214
D+ G + + S +DKPL+ E + +EY++ + ++ +SEE
Sbjct: 287 PSDLIGPEAPKTLTSQDDKPLNYGHALLPGEGAAMAEYVKAGKRIPRRGEIGLTSEEIAS 346
Query: 215 -----------REKATEKTKKKKKHKKHSKKKKKKAAS 241
R + E + +K+++ +S +K+ AS
Sbjct: 347 FECSGYVMSGSRHRRMEAVRLRKENQIYSADEKRALAS 384
Score = 68.2 bits (165), Expect = 6e-12
Identities = 49/178 (27%), Positives = 84/178 (47%), Gaps = 21/178 (11%)
Query: 69 WKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQ 128
W L+K RE+ L RQ++ E+++ G + + DS++ +
Sbjct: 114 WPSLLDKEREESL---------RQKRLSERERIGELGAPEVWGLSPKNPEPDSDEHTPVE 164
Query: 129 GKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDK 188
+ KK S +S S +E + K KK +SK+ ++K + K +K K YSED
Sbjct: 165 DEEPKK--------STTSASTSEEEKK---KKSSRSKERSKKRRKKKSSKRKHKKYSEDS 213
Query: 189 PLSSESLSES-EYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSSPD 245
S+S ++S + + RAKK K E+++K K KKK+ KK K+ ++ S +
Sbjct: 214 DSDSDSETDSSDEDNKRRAKKAKKKEKKKKHRSKKYKKKRSKKSRKESSDSSSKESQE 271
Score = 56.2 bits (134), Expect = 3e-08
Identities = 46/178 (25%), Positives = 79/178 (44%), Gaps = 10/178 (5%)
Query: 41 WEEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKK 100
W + ++ ++ K L+E E++ E E+ K E S + + E+ K
Sbjct: 114 WPSLLDKEREESLRQKRLSE-RERIGELGAPEVWGLSPK---NPEPDSDEHTPVEDEEPK 169
Query: 101 SGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKK 160
S+S+S SS E K++ K+ K+K++ + S S++E+DS D
Sbjct: 170 KSTTSASTSEEEKKKKSSRSKERSKKRRKKKSSKRKHKKYSEDSDSDSDSETDSSDE-DN 228
Query: 161 KKKSKDGTEKEKDIKGLSKKRKMYSEDKPL-----SSESLSESEYIEEVRAKKKKSSE 213
K+++K +KEK K SKK K K SS S+ E++E + K+ E
Sbjct: 229 KRRAKKAKKKEKKKKHRSKKYKKKRSKKSRKESSDSSSKESQEEFLENPWKDRTKAEE 286
>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 275
Score = 75.5 bits (184), Expect = 4e-14
Identities = 47/202 (23%), Positives = 97/202 (48%), Gaps = 14/202 (6%)
Query: 40 TWEEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKK 99
T E + + E++++ + +E+ E KKE +K R+K G E K+++R+K+ K+
Sbjct: 30 TQRESERKKERREREKRKREREKERKRERGKKE-KKKRKKRERGKERERKRKEREKQRKE 88
Query: 100 KSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLK 159
+ + + + ++KQ RR++KK + K E + + +
Sbjct: 89 R---------REKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRR 139
Query: 160 KKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKAT 219
KKK+ K+ +++ K K++K E++ E E E + +++K ER+K
Sbjct: 140 KKKRRKERKREKERGKRERKRKKRKKEER----EKKRERNRKERKKERERKERRERKKER 195
Query: 220 EKTKKKKKHKKHSKKKKKKAAS 241
+K ++KKK +K +K ++ S
Sbjct: 196 KKERRKKKERKKDRKTDRQTDS 217
Score = 73.6 bits (179), Expect = 2e-13
Identities = 41/187 (21%), Positives = 83/187 (44%), Gaps = 2/187 (1%)
Query: 60 EFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSS 119
E E K +++ ++ REK +K++RKK+E+ K
Sbjct: 33 ESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREK 92
Query: 120 DSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSK 179
+ K++ KR +K++ R + + E E ++K ++K+K + ++ K+ K +
Sbjct: 93 ERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKE 152
Query: 180 KRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKA 239
+ K + K E + E R ++KK E +E+ K ++KK+ +K ++KK +
Sbjct: 153 RGKRERKRKKRKKEEREKKR--ERNRKERKKERERKERRERKKERKKERRKKKERKKDRK 210
Query: 240 ASSSPDS 246
DS
Sbjct: 211 TDRQTDS 217
Score = 59.3 bits (142), Expect = 3e-09
Identities = 39/131 (29%), Positives = 66/131 (50%), Gaps = 8/131 (6%)
Query: 110 SSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTE 169
S S S + E E KK+ + R+K+K K + + E KK+KK + G E
Sbjct: 21 SCSHISKPCTQRESERKKERREREKRKREREKERKRERGKKEK------KKRKKRERGKE 74
Query: 170 KEKDIKGLSKKRKMYSE-DKPLSSESLSESEYIEEVRAKKKKSSEEREKATE-KTKKKKK 227
+E+ K K+RK E ++ + + E + R ++KK E +E+ E K ++++K
Sbjct: 75 RERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERK 134
Query: 228 HKKHSKKKKKK 238
KK KKK++K
Sbjct: 135 RKKRRKKKRRK 145
Score = 48.9 bits (115), Expect = 4e-06
Identities = 38/180 (21%), Positives = 79/180 (43%), Gaps = 30/180 (16%)
Query: 18 RSRGPIQSSGPTIQDYLNRPRPTWEEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHR 77
R RG + ++ + R E K + EKKK+ K E K + K+ +++
Sbjct: 69 RERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENK 128
Query: 78 EKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKN 137
++ + KK++RK+++++K + K++ KR+K+KK
Sbjct: 129 QRRERKRKKRRKKKRRKERKREK----------------------ERGKRERKRKKRKKE 166
Query: 138 RSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSE 197
K E + E KK+++ K+ E++K+ K +K+K +D+ ++ S+
Sbjct: 167 EREKKRERNRKER--------KKERERKERRERKKERKKERRKKKERKKDRKTDRQTDSQ 218
Score = 43.9 bits (102), Expect = 1e-04
Identities = 24/113 (21%), Positives = 56/113 (49%), Gaps = 3/113 (2%)
Query: 45 KEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRY 104
K++ +++++ +K E + K K+ E+ REK E KKR+++++EKK R
Sbjct: 117 KKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKK---RE 173
Query: 105 SSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDS 157
+ + +++K+ +R+KK++ + K+ + S+ ++S
Sbjct: 174 RNRKERKKERERKERRERKKERKKERRKKKERKKDRKTDRQTDSQVFRPLRES 226
>gi|156104889 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 3 [Homo sapiens]
Length = 568
Score = 75.5 bits (184), Expect = 4e-14
Identities = 55/165 (33%), Positives = 76/165 (46%), Gaps = 2/165 (1%)
Query: 82 SGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHK 141
S S SSS S SSSSSSSS SSSSSS S K K K+ K + K
Sbjct: 150 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSKPHKLMKEHKEKPSK 209
Query: 142 SSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKM-YSEDKPLSSESLSESEY 200
S S + S+D K K+S ++ K +K KM + E KP+S E +S
Sbjct: 210 DSREHKSAFKEPSRDHNKSSKESSKKPKENKPLKEEKIVPKMAFKEPKPMSKEPKPDSNL 269
Query: 201 IEEVRAKKKKSSEEREKATEKTK-KKKKHKKHSKKKKKKAASSSP 244
+ + KK+ +R ++ + KK KK S + K+ SS+P
Sbjct: 270 LTITSGQDKKAPSKRPPISDSEELSAKKRKKSSSEALFKSFSSAP 314
Score = 42.4 bits (98), Expect = 4e-04
Identities = 37/177 (20%), Positives = 76/177 (42%), Gaps = 12/177 (6%)
Query: 45 KEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRY 104
K+Q++ K + E + +E K L + ++ ++S ++ K + ++
Sbjct: 324 KKQIKDKSHVKMGKVKIESETSEKKKSTLPPF-DDIVDPNDSDVEENISSKSDSEQP--- 379
Query: 105 SSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKS 164
S +SS SSSSSS + + ++QG R K+ +E E E + DS ++ +
Sbjct: 380 ---SPASSSSSSSSSFTPSQTRQQGPLRSIMKDLHSDDNEEESDEVEDNDNDSEMERPVN 436
Query: 165 KDGTEKEKDIKGLSKKRKMYSEDKPLSSES-----LSESEYIEEVRAKKKKSSEERE 216
+ G+ + + S PL E + + I EV++ K+S +++
Sbjct: 437 RGGSRSRRVSLSDGSDSESSSASSPLHHEPPPPLLKTNNNQILEVKSPIKQSKSDKQ 493
Score = 31.2 bits (69), Expect = 0.87
Identities = 42/214 (19%), Positives = 83/214 (38%), Gaps = 37/214 (17%)
Query: 37 PRPTWEEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKK 96
P+ ++E K ++ K S L + K+ R + E S+KKR++
Sbjct: 249 PKMAFKEPKPMSKEPKPDSNLLT-----ITSGQDKKAPSKRPPISDSEELSAKKRKKSSS 303
Query: 97 EKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKD 156
E + S SS+ + S+D +K+ K++SH M + + +S+
Sbjct: 304 E----ALFKSFSSAPPLILTCSAD-----------KKQIKDKSH----VKMGKVKIESET 344
Query: 157 SLKKKKKSKDGTE----KEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSS 212
S KKK + + D++ + + P SS S S S + S
Sbjct: 345 SEKKKSTLPPFDDIVDPNDSDVEENISSKSDSEQPSPASSSSSSSSSF---------TPS 395
Query: 213 EEREKATEKTKKKKKHKKHSKKKKKKAASSSPDS 246
+ R++ ++ K H ++++ + + DS
Sbjct: 396 QTRQQGPLRSIMKDLHSDDNEEESDEVEDNDNDS 429
>gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]
Length = 494
Score = 74.3 bits (181), Expect = 9e-14
Identities = 57/221 (25%), Positives = 110/221 (49%), Gaps = 24/221 (10%)
Query: 50 KKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKK---------- 99
K + SK AE + + N+N K + + S S+S S+ ++R+ +E+K
Sbjct: 264 KSRSKSKDQAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQ 323
Query: 100 -KSGRYSSSSSSS--SDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSM-------SE 149
KS R S S S S S S S S+ +DK++G++R ++++RS S S S+
Sbjct: 324 EKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSK 383
Query: 150 TESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYI---EEVRA 206
+S + S KKKK+ D ++ + +SK+R+ +++ + E ESE +E R+
Sbjct: 384 RDSKAGSSKKKKKEDTDRSQSRSPSRSVSKERE-HAKSESSQREGRGESENAGTNQETRS 442
Query: 207 KKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSSPDSP 247
+ + +S+ + +++ + K ++ + K + S+ SP
Sbjct: 443 RSRSNSKSKPNLPSESRSRSKSASKTRSRSKSRSRSASRSP 483
Score = 70.5 bits (171), Expect = 1e-12
Identities = 54/210 (25%), Positives = 100/210 (47%), Gaps = 12/210 (5%)
Query: 45 KEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRY 104
K +L + K GS+ + + + + +H K S S SSK K + + +SG
Sbjct: 169 KIRLVEDKPGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRS-GSSKSSHSKSRSRSRSGSR 227
Query: 105 SSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSES-SMSETESDSK----DSLK 159
S S S S S S S E K + ++K ++RSH + +S S S+ +++ K D++
Sbjct: 228 SRSKSRSRSQSRSRSKKE---KSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVG 284
Query: 160 KKKKSKDGTEKEKD-IKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKK--KKSSEERE 216
K K K K + S++R++ E + S S+ + + + R++ K S R
Sbjct: 285 KPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRS 344
Query: 217 KATEKTKKKKKHKKHSKKKKKKAASSSPDS 246
++ K+K K+K +K S+++ + + S S
Sbjct: 345 RSRSKSKDKRKGRKRSREESRSRSRSRSKS 374
Score = 69.3 bits (168), Expect = 3e-12
Identities = 54/220 (24%), Positives = 98/220 (44%), Gaps = 17/220 (7%)
Query: 21 GPIQSSGPTIQDYLNRPRPTWEEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKL 80
G +S P+ ++ R +E ++E++K+GS + +EK L + R +
Sbjct: 284 GKPKSRSPSRHKSKSKSRSRSQE--RRVEEEKRGSVSRGRSQEK-------SLRQSRSRS 334
Query: 81 LSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDE------DKKQGKRRKK 134
S S S+ R R K + K+ GR S S S S S S D K G +KK
Sbjct: 335 RSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKK 394
Query: 135 KKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSES 194
KK + +S S S + S ++ K + ++G E + G +++ + S S +
Sbjct: 395 KKEDTDRSQSRSPSRSVSKEREHAKSESSQREG-RGESENAGTNQETRSRSRSNSKSKPN 453
Query: 195 L-SESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSK 233
L SES + +K + S+ R ++ ++ + + + HS+
Sbjct: 454 LPSESRSRSKSASKTRSRSKSRSRSASRSPSRSRSRSHSR 493
Score = 63.5 bits (153), Expect = 2e-10
Identities = 49/185 (26%), Positives = 86/185 (46%), Gaps = 18/185 (9%)
Query: 70 KKELEKHREKLLSGSESSSKKRQRK------KKEKKKSGRYSSSSSSSSDSSSSSSDSED 123
K K R + SGS S SK R R KKEK +S S S S + S S S+D
Sbjct: 212 KSSHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKD 271
Query: 124 EDKKQ-------GKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKG 176
+ +++ GK + + +R HKS S S ++ + K+ S+ G +EK ++
Sbjct: 272 QAEEKIQNNDNVGKPKSRSPSR-HKSKSKSRSRSQERRVEEEKRGSVSR-GRSQEKSLRQ 329
Query: 177 LSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKK 236
+ + + S S S S+ ++ + +K+ E R ++ ++K ++ K+ SK+
Sbjct: 330 SRSRSRSKGGSR---SRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDS 386
Query: 237 KKAAS 241
K +S
Sbjct: 387 KAGSS 391
Score = 56.6 bits (135), Expect = 2e-08
Identities = 59/235 (25%), Positives = 97/235 (41%), Gaps = 51/235 (21%)
Query: 50 KKKKGSKALAEFEEKMNENWKKELEKHR----EKLLSGSESSSKKRQRKKKEK------- 98
+ + GS++ ++ + + + EK R EK S S S+ K R + K +
Sbjct: 221 RSRSGSRSRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNN 280
Query: 99 ----KKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGK-----------RRKKKKNRSHKSS 143
K R S S S S S S + E++K+G R+ + ++RS K
Sbjct: 281 DNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRS-KGG 339
Query: 144 ESSMSETESDSKDSLKKKKKSKDGTE----------------KEKDIK-GLSKKRKMYSE 186
S S + S SKD K +K+S++ + ++D K G SKK+K
Sbjct: 340 SRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDT 399
Query: 187 DKPLSSESLSESEYIEEVRAKKKKSSEEREKATEK----TKKKKKHKKHSKKKKK 237
D+ S+S S S + + R K S +RE E T ++ + + S K K
Sbjct: 400 DR---SQSRSPSRSVSKEREHAKSESSQREGRGESENAGTNQETRSRSRSNSKSK 451
Score = 54.3 bits (129), Expect = 1e-07
Identities = 52/212 (24%), Positives = 93/212 (43%), Gaps = 24/212 (11%)
Query: 38 RPTWEEVKEQLEKK--------KKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSK 89
R +W+++K+ + + KG K E + K+ LEK L G+E + +
Sbjct: 114 RCSWQDLKDYMRQAGEVTYADAHKGRKNEGVIEFVSYSDMKRALEK-----LDGTEVNGR 168
Query: 90 K-RQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRK---KKKNRSHKSSES 145
K R + K + R S S S S S S S S + G + K ++RS S S
Sbjct: 169 KIRLVEDKPGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRS 228
Query: 146 -SMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEV 204
S S + S S+ KK+K EK + + K + S+D+ + E + ++ +
Sbjct: 229 RSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQ--AEEKIQNNDNV--- 283
Query: 205 RAKKKKSSEEREKATEKTKKKKKHKKHSKKKK 236
K K S R K+ K++ + + ++ ++K+
Sbjct: 284 -GKPKSRSPSRHKSKSKSRSRSQERRVEEEKR 314
>gi|239508778 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 123
Score = 72.4 bits (176), Expect = 3e-13
Identities = 47/143 (32%), Positives = 75/143 (52%), Gaps = 21/143 (14%)
Query: 93 RKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKN-RSHKSSESSMSETE 151
+KKK+KKK ++ + + ++E+E++K+GKR++K+K R K + ETE
Sbjct: 1 KKKKKKKKE----------TEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETE 50
Query: 152 SDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKS 211
K+K K+ EK++ K KK + E++ E E E EE R +KKK
Sbjct: 51 ---------KRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKK- 100
Query: 212 SEEREKATEKTKKKKKHKKHSKK 234
+ R K E+ KKKK+ +K KK
Sbjct: 101 KKRRRKEEEEEKKKKRRRKTKKK 123
Score = 65.5 bits (158), Expect = 4e-11
Identities = 38/124 (30%), Positives = 63/124 (50%), Gaps = 14/124 (11%)
Query: 42 EEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKS 101
EE +E E+++K K + +EK E KK+ K EK E K+++++KK+K++
Sbjct: 14 EETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRKKKKEEE 73
Query: 102 GRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKK 161
R + + E+E+K++G+RRKKKK R K E E + K ++K
Sbjct: 74 ER-------EEEEEEEEEEKEEEEKEEGRRRKKKKKRRRK-------EEEEEKKKKRRRK 119
Query: 162 KKSK 165
K K
Sbjct: 120 TKKK 123
Score = 62.8 bits (151), Expect = 3e-10
Identities = 41/136 (30%), Positives = 66/136 (48%), Gaps = 20/136 (14%)
Query: 49 EKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSS 108
+KKKK K E EE +E E+ EK G +K +RK+KEKKK +
Sbjct: 1 KKKKKKKKETEETEET------EETEEEEEK--EGKRKEKRKEKRKEKEKKKKTK----- 47
Query: 109 SSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHK--SSESSMSETESDSKDSLKKKKKSKD 166
+ + E+E+KK+ ++RKKKK + E E E + K+ +++KK K
Sbjct: 48 -----ETEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKK 102
Query: 167 GTEKEKDIKGLSKKRK 182
KE++ + K+R+
Sbjct: 103 RRRKEEEEEKKKKRRR 118
Score = 29.3 bits (64), Expect = 3.3
Identities = 16/48 (33%), Positives = 30/48 (62%), Gaps = 7/48 (14%)
Query: 205 RAKKKKSSEEREKATEKTKK------KKKHKKHSKKKKKKAASSSPDS 246
+ KKKK +EE E+ TE+T++ K+K K+ K+K+K+ + ++
Sbjct: 3 KKKKKKETEETEE-TEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKET 49
>gi|40068059 CBF1 interacting corepressor [Homo sapiens]
Length = 450
Score = 71.2 bits (173), Expect = 8e-13
Identities = 46/190 (24%), Positives = 91/190 (47%), Gaps = 14/190 (7%)
Query: 60 EFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKE--------KKKSGRYSSSSSSS 111
EF + + K++L + ++L E KK+ RKKK+ KK SSSSSSS
Sbjct: 211 EFLKSLTTKQKQKLLRKLDRL----EKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSS 266
Query: 112 SDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKE 171
S SS+ +S+S E + K +K ++ + K+ S + ++S+ KD KK+K ++ +
Sbjct: 267 SSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSH 326
Query: 172 KDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKH 231
+ + +K + + S S+ + +++ K S E+ + K + H +
Sbjct: 327 HNREKAKEKPRFLKHESSREDSKWSHSD--SDKKSRTHKHSPEKRGSERKEGSSRSHGRE 384
Query: 232 SKKKKKKAAS 241
+ ++ ++ S
Sbjct: 385 ERSRRSRSRS 394
Score = 55.1 bits (131), Expect = 6e-08
Identities = 51/189 (26%), Positives = 81/189 (42%), Gaps = 41/189 (21%)
Query: 59 AEFEEKMNENWKKELE-KHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSS 117
+E EE + K L K ++KLL + KK+++K ++KKK
Sbjct: 202 SEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKF---------------- 245
Query: 118 SSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGL 177
++ + K++ HKSS SS S + S S + + KEK I+
Sbjct: 246 -------------QKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQ-- 290
Query: 178 SKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKA---TEKTKKKKKHKKHSKK 234
KKRK S + S+SE E+ ++KK+K EE + EK K+K + KH
Sbjct: 291 RKKRKK----NKCSGHNNSDSE--EKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESS 344
Query: 235 KKKKAASSS 243
++ S S
Sbjct: 345 REDSKWSHS 353
Score = 47.0 bits (110), Expect = 2e-05
Identities = 35/121 (28%), Positives = 55/121 (45%), Gaps = 2/121 (1%)
Query: 45 KEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRY 104
K+ KK+K +K E K + K E+L S + K +++ + K +S R
Sbjct: 287 KKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSR- 345
Query: 105 SSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKS 164
S S SDS S + +K+G RK+ +RSH E S + S S S K+++
Sbjct: 346 EDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREERS-RRSRSRSPGSYKQRETR 404
Query: 165 K 165
K
Sbjct: 405 K 405
Score = 40.8 bits (94), Expect = 0.001
Identities = 33/91 (36%), Positives = 45/91 (49%), Gaps = 12/91 (13%)
Query: 156 DSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEER 215
D L+KKKK KD +K+K K SK +K S SS S S S E SS E
Sbjct: 229 DRLEKKKKKKD-RKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSE-------SSSE- 279
Query: 216 EKATEKTKKKKKHKKHSKKKKKKAASSSPDS 246
+E K+KK ++ +KK K + ++ DS
Sbjct: 280 ---SESNNKEKKIQRKKRKKNKCSGHNNSDS 307
Score = 40.0 bits (92), Expect = 0.002
Identities = 36/150 (24%), Positives = 67/150 (44%), Gaps = 15/150 (10%)
Query: 102 GRYSSSSSSSSDSSSSSSDSEDE-DKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKK 160
GR +++ S + +S + + E + + K+K+ K + + D K +
Sbjct: 187 GRNLTANDPSQEYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQ 246
Query: 161 KKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKK-------SSE 213
K +SK K S +E SSES S ++ + R K+KK +S+
Sbjct: 247 KSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSD 306
Query: 214 EREKATEKTKKKKKHKK-----HSKKKKKK 238
EK +K+KK+K H++ H+++K K+
Sbjct: 307 SEEK--DKSKKRKLHEELSSSHHNREKAKE 334
Score = 34.7 bits (78), Expect = 0.079
Identities = 54/245 (22%), Positives = 94/245 (38%), Gaps = 50/245 (20%)
Query: 43 EVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSES-------------SSK 89
E K +KKK +E++ + + KE E + +LL G E +K
Sbjct: 29 EQKISYDKKK---------QEELMQQYLKEQESYDNRLLMGDERVKNGLNFMYEAPPGAK 79
Query: 90 KRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSED-EDKKQGKR-RKKKKNRSHK------ 141
K ++K+E + Y + + D + D+ G + R + + HK
Sbjct: 80 KENKEKEETEGETEYKFEWQKGAPREKYAKDDMNIRDQPFGIQVRNVRCIKCHKWGHVNT 139
Query: 142 ---------SSESSMSETESDSKDSLKKKK----KSKDGTEKEKDIKGLSKKRKMYSEDK 188
S ++ S S S+ + G ++++ G + S++
Sbjct: 140 DRECPLFGLSGINASSVPTDGSGPSMHPSELIAEMRNSGFALKRNVLGRNLTANDPSQEY 199
Query: 189 PLSS-ESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKK------HSKKKKKKAAS 241
S E E E+++ + K+K+ + EK KKKK KK SK KK K++S
Sbjct: 200 VASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSS 259
Query: 242 SSPDS 246
SS S
Sbjct: 260 SSSSS 264
Score = 33.9 bits (76), Expect = 0.13
Identities = 14/46 (30%), Positives = 25/46 (54%)
Query: 201 IEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSSPDS 246
++ + KKKK +++K + K KKHK S ++SSS ++
Sbjct: 228 LDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTET 273
Score = 33.5 bits (75), Expect = 0.18
Identities = 25/137 (18%), Positives = 49/137 (35%), Gaps = 7/137 (5%)
Query: 50 KKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSS 109
++K SK EE + + +E K + + L S + KKS + S
Sbjct: 308 EEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPE 367
Query: 110 SSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTE 169
S +++ +R + + S+K E+ + ++ ++ GT+
Sbjct: 368 KRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETRKRAQRNPGEEQSRRNDSRSHGTD 427
Query: 170 KEKDIKGLSKKRKMYSE 186
L + KMY E
Sbjct: 428 -------LYRGEKMYRE 437
>gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1
[Homo sapiens]
Length = 651
Score = 71.2 bits (173), Expect = 8e-13
Identities = 70/240 (29%), Positives = 118/240 (49%), Gaps = 26/240 (10%)
Query: 29 TIQDYLNRPRPTWEEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSS 88
T +D + + + E + KK SK + + +K ++ KK+++K E + S S
Sbjct: 284 TKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKK--DDKKKDVKKDTESTDAESGDSK 341
Query: 89 KKRQRKKKEKKK---------SGRY-SSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNR 138
+R+ KK+KKK + +Y S+ + S D+ + +DS + KK K KKK+
Sbjct: 342 DERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNL-KKASKNDDKKKD- 399
Query: 139 SHKSSESSMSETESDSKDSLKKKKKSK--DGTEKEKDIKGLSKKRKMYSEDKPLSSESLS 196
+ K + S+ SE+E +SK+S K +KK K T+ +K +K + SE K S +
Sbjct: 400 AKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKK 459
Query: 197 ESEYIEEVRAK--KKKSSEEREKATE--------KTKKKKKHKKHSKKKKKKAASSSPDS 246
+ + ++ K KKK +++ ++TE K KK K KK SKK KK A +S
Sbjct: 460 DEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTES 519
Score = 66.2 bits (160), Expect = 2e-11
Identities = 56/189 (29%), Positives = 98/189 (51%), Gaps = 21/189 (11%)
Query: 66 NENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDE- 124
N++ KK+ +K S SE SK+ Q+ +K+ KK + + S +D S+ +DSE +
Sbjct: 393 NDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKG 452
Query: 125 DKKQGKRRKKK------KNRSHKSSESSMSETESDSKDSLKK-KKKSKDGTEKEKDIKGL 177
D K+GK+ +KK K+ K ++ + TE +S LKK KK SK+ +KDIK
Sbjct: 453 DSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIK-- 510
Query: 178 SKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKK 237
+D +ES +++E+ E + K S++ + TE ++ +K +KKK
Sbjct: 511 --------KDARKDTES-TDAEFDESSKTGFKTSTKIKGSDTE--SEESLYKPGAKKKID 559
Query: 238 KAASSSPDS 246
++ +S +S
Sbjct: 560 ESDGTSANS 568
Score = 64.7 bits (156), Expect = 7e-11
Identities = 57/214 (26%), Positives = 96/214 (44%), Gaps = 21/214 (9%)
Query: 45 KEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGS--------ESSSKKRQRKKK 96
K++ + KK K L + ++K K+ +K+ E + S +S + K+ K
Sbjct: 341 KDERKDTKKDKKKLKKDDKK------KDTKKYPESTDTESGDAKDARNDSRNLKKASKND 394
Query: 97 EKKKSGR---YSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESD 153
+KKK + +S+ S S +S S D E +DKK K KK ++ + S + SE + D
Sbjct: 395 DKKKDAKKITFSTDSESELESKESQKD-EKKDKKDSKTDNKKSVKNDEESTDADSEPKGD 453
Query: 154 SKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSE 213
SK K +KK K + +KD K K+ S + E + ++ +E + KK +
Sbjct: 454 SKKGKKDEKKGK--KDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKK 511
Query: 214 EREKATEKTKKK-KKHKKHSKKKKKKAASSSPDS 246
+ K TE T + + K K K S +S
Sbjct: 512 DARKDTESTDAEFDESSKTGFKTSTKIKGSDTES 545
Score = 62.4 bits (150), Expect = 4e-10
Identities = 52/194 (26%), Positives = 82/194 (42%), Gaps = 15/194 (7%)
Query: 62 EEKMN-ENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSD 120
+E +N + W + ++ K S + K+ KK KK SS + S DS + D
Sbjct: 256 DESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKK------SSDAESEDSKDAKKD 309
Query: 121 SEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKK 180
S+ K K KKK + S + S D + KK KK +K+KD K +
Sbjct: 310 SKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPES 369
Query: 181 RKMYS---EDKPLSSESLSESEYIEEVRAKKKK-----SSEEREKATEKTKKKKKHKKHS 232
S +D S +L ++ ++ + KK SE ++ E K +KK KK S
Sbjct: 370 TDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDS 429
Query: 233 KKKKKKAASSSPDS 246
K KK+ + +S
Sbjct: 430 KTDNKKSVKNDEES 443
Score = 55.1 bits (131), Expect = 6e-08
Identities = 42/181 (23%), Positives = 85/181 (46%), Gaps = 8/181 (4%)
Query: 42 EEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKS 101
+E K++ + K K++ EE + + + + + + K + K+ KK +KKK
Sbjct: 421 DEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGK----KDEKKGKKDSKKDDKKKD 476
Query: 102 GRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKK 161
+ ++ S+ D + +K+G ++ KK+ + K +ES+ +E + SK K
Sbjct: 477 AKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKD-ARKDTESTDAEFDESSKTGFKTS 535
Query: 162 KKSK-DGTEKEKDIKGLSKKRKMYSEDKPLSSESLS--ESEYIEEVRAKKKKSSEEREKA 218
K K TE E+ + K+K+ D ++ + ES+ + +KK +E+ EKA
Sbjct: 536 TKIKGSDTESEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEKGEKA 595
Query: 219 T 219
+
Sbjct: 596 S 596
Score = 52.8 bits (125), Expect = 3e-07
Identities = 50/213 (23%), Positives = 92/213 (43%), Gaps = 32/213 (15%)
Query: 50 KKKKGSKALAEFEEKMNENW-----KKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRY 104
K +KG L + +K ++ K++ + + K + ++ + K + ++ KKS
Sbjct: 119 KDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKSS 178
Query: 105 SSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKS 164
S ++ S +S + S + +DKK K KK + + T+++ K LK+ K S
Sbjct: 179 SETNPESQNSKTVSKNCSQKDKKDSKNSKK--------TNTEFLHTKNNPKKDLKRSKTS 230
Query: 165 KDGTEKEKDIKGLSKKRKM---YSEDKPLSSE--------------SLSESEYIEEVRAK 207
D + L+ M S+D+ ++ + SL ++Y ++ K
Sbjct: 231 NDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKK 290
Query: 208 --KKKSSEEREKATEKTKKKKKHKKHSKKKKKK 238
KK S E E + + K KK KK+ KK KK
Sbjct: 291 NAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKK 323
Score = 50.4 bits (119), Expect = 1e-06
Identities = 61/263 (23%), Positives = 102/263 (38%), Gaps = 53/263 (20%)
Query: 22 PIQSSGPTIQDYLNRPRPTWEEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLL 81
P++SS Q ++ + E + + K SK ++ ++K ++N KK + L
Sbjct: 162 PLKSSHENEQ---SKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKT----NTEFL 214
Query: 82 SGSESSSKKRQRKKKEKKKSGRYSSSSS---------SSSDSSS----------SSSDSE 122
+ K +R K S +S SD S S ++S+
Sbjct: 215 HTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSK 274
Query: 123 DEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRK 182
+ K K KK ++ K S + SE D+K KK KK+ +K+KD+K ++
Sbjct: 275 NYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTD 334
Query: 183 MYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKK------------------ 224
S D S+ E + + KKK ++++K T+K +
Sbjct: 335 AESGD--------SKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRN 386
Query: 225 -KKKHKKHSKKKKKKAASSSPDS 246
KK K KKK K + S DS
Sbjct: 387 LKKASKNDDKKKDAKKITFSTDS 409
Score = 49.3 bits (116), Expect = 3e-06
Identities = 44/167 (26%), Positives = 68/167 (40%), Gaps = 16/167 (9%)
Query: 45 KEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRY 104
K+ + +KKG K + ++ KK+ +K+ E S+ KK ++ KEKK S +
Sbjct: 455 KKGKKDEKKGKK------DSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKK- 507
Query: 105 SSSSSSSSDSSSSSSDSE-DEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKK 163
+ + S+D+E DE K G + K S SE S+ K KKK
Sbjct: 508 --DIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEESLY------KPGAKKKID 559
Query: 164 SKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKK 210
DGT ++GL KR K + E V ++K
Sbjct: 560 ESDGTSANSKMEGLESKRGFRMSSKKTTFNEKGEKASTGRVPPSREK 606
Score = 40.8 bits (94), Expect = 0.001
Identities = 50/236 (21%), Positives = 99/236 (41%), Gaps = 34/236 (14%)
Query: 45 KEQLEKKKKGSKALAEFEEKMNENWKKELEKHREK-----LLSGSESSSKKRQRKKKEKK 99
K +LE+ +K + + W RE+ L + K +K K++K
Sbjct: 63 KRKLEEGQKPAHKWIRHSFRKILQWPPIYTAAREQTPFRHLYTSKTHLKKAEYKKSKDEK 122
Query: 100 KSGRYSSSSSSSSDSSSSSSDS----EDEDKKQGKRRKKKKNRSHKSSESSMSETESDSK 155
S S +++ +S E++ K+Q + K SH++ +S S++ S++
Sbjct: 123 GGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSETN 182
Query: 156 -DSLKKKKKSKDGTEKEKDIKGLSKKRK---MYSEDKPLS--SESLSESEYIEEVRAKKK 209
+S K SK+ ++K+K SKK +++++ P S + ++ I E+ ++
Sbjct: 183 PESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENS 242
Query: 210 ----------KSSEE--------REKATEKTKK-KKKHKKHSKKKKKKAASSSPDS 246
+S +E R + +K K+ K++KK KK A S D+
Sbjct: 243 LNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDA 298
Score = 32.7 bits (73), Expect = 0.30
Identities = 30/93 (32%), Positives = 39/93 (41%), Gaps = 21/93 (22%)
Query: 155 KDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEE 214
K KK K K GT +KD K KK Y+ + ES+ I E + K
Sbjct: 112 KAEYKKSKDEKGGTPLKKDSK---KKGGSYATNP--------ESKQIVEEKTK------- 153
Query: 215 REKATEKTKKKKKHKKHSKKKKKKAASSSPDSP 247
R+ +KT K H+ KK K SSS +P
Sbjct: 154 RQNEADKTPLKSSHENEQSKKSK---SSSETNP 183
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 70.1 bits (170), Expect = 2e-12
Identities = 57/212 (26%), Positives = 102/212 (48%), Gaps = 17/212 (8%)
Query: 43 EVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSG 102
++++Q E G++ L E EE + + K +++ + G + S K R + K+K +
Sbjct: 966 KMEQQYESSSDGTEKLPEREEICH--FPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELS 1023
Query: 103 RYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKK---NRSHKSSESSMSETES-----DS 154
Y+ S+ DS SS D + ++ G+ +K+ K S K + S S+TE D
Sbjct: 1024 DYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDG 1083
Query: 155 KDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEE 214
+S K+ K + E+ + LS KR + + S S S++E E KKK+ +
Sbjct: 1084 CNSSDKRLKRIELRER----RNLSSKR---NTKEIQSGSSSSDAEESSEDNKKKKQRTSS 1136
Query: 215 REKATEKTKKKKKHKKHSKKKKKKAASSSPDS 246
++KA +KK+ + S K+K+ +SS S
Sbjct: 1137 KKKAVIVKEKKRNSLRTSTKRKQADITSSSSS 1168
Score = 64.7 bits (156), Expect = 7e-11
Identities = 61/219 (27%), Positives = 100/219 (45%), Gaps = 39/219 (17%)
Query: 35 NRPRPTWEEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRK 94
N P EE K Q+ S++ ++ EE ++ L +H+ + G KK + K
Sbjct: 1269 NEENPGDEEAKNQVN-----SESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPK 1323
Query: 95 K-KEKKKSGRYSSSSSSSSDS-------SSSSSDSEDEDKKQGKRRKK----KKNRSHKS 142
+ KE K R SS S DS S S+SEDE + + + KK + RS+K
Sbjct: 1324 EHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQ 1383
Query: 143 ---------SESSMSETESDSKDSLKKKKKSKDGTEKEKDI------------KGLSKKR 181
E S SE +S+S++ ++K++ ++ E+E++ KG K R
Sbjct: 1384 KKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIR 1443
Query: 182 KMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATE 220
K+ +DK L +E+ + + EE R + + EREK E
Sbjct: 1444 KILKDDK-LRTETQNALKEEEERRKRIAEREREREKLRE 1481
Score = 53.5 bits (127), Expect = 2e-07
Identities = 46/163 (28%), Positives = 79/163 (48%), Gaps = 35/163 (21%)
Query: 115 SSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSM----SETESDSKDSLK----------- 159
SS S D++ ++GK+R K+N + E + SE++SDS++S K
Sbjct: 1247 SSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHK 1306
Query: 160 ---------KKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLS-------SESLSESEYIEE 203
++KK+K ++ K++KG +RK+ SED S SE +SESE +
Sbjct: 1307 LTVSDGESGEEKKTKP--KEHKEVKG-RNRRKVSSEDSEDSDFQESGVSEEVSESEDEQR 1363
Query: 204 VRAKKKKSSE-EREKATEKTKKKKKHKKHSKKKKKKAASSSPD 245
R + K +E E + + K KKK++ K + + S+S +
Sbjct: 1364 PRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEE 1406
Score = 53.5 bits (127), Expect = 2e-07
Identities = 42/186 (22%), Positives = 87/186 (46%), Gaps = 5/186 (2%)
Query: 25 SSGPTIQDYLNRPRPTWEEVKEQLEKKKKGSKALAEFEEK-MNENWKKELEKHREKLLSG 83
S G + ++ +P+ E K ++F+E ++E + ++ R + S
Sbjct: 1310 SDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSA 1369
Query: 84 SESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSS 143
++ ++ QR K+KKK R SSS++ S+S E+E++K+ + ++++ +
Sbjct: 1370 KKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSE--EEEEEKEEEEEEEEEEEEEEED 1427
Query: 144 ESSMSETESDSKDSLKK-KKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIE 202
E+ S++ + ++K K K TE + +K ++RK +E + E L E IE
Sbjct: 1428 ENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAE-REREREKLREVIEIE 1486
Query: 203 EVRAKK 208
+ K
Sbjct: 1487 DASPTK 1492
Score = 48.5 bits (114), Expect = 5e-06
Identities = 56/245 (22%), Positives = 108/245 (44%), Gaps = 60/245 (24%)
Query: 50 KKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSS 109
K+ + + ++ EE +N KK+ +SSKK+ KEKK++ +S+
Sbjct: 1109 KEIQSGSSSSDAEESSEDNKKKK-----------QRTSSKKKAVIVKEKKRNSLRTSTKR 1157
Query: 110 SSSD-SSSSSSDSEDEDKK---QGKRRKKKKN--------RSH-----KSSESSMSET-- 150
+D +SSSSSD ED+D+ +G ++K SH S + ++S++
Sbjct: 1158 KQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVP 1217
Query: 151 --------ESDSKDSLKKK----------KKSKDGTEKEKDIKGLSKKRKMYSED----- 187
++D ++ + KK +DG+ ++ +G + K E+
Sbjct: 1218 VTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEE 1277
Query: 188 --KPLSSESLSESEYIEEVR-----AKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAA 240
++SES S+SE ++ R + K + + E EK K K+HK+ + ++K +
Sbjct: 1278 AKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVS 1337
Query: 241 SSSPD 245
S +
Sbjct: 1338 SEDSE 1342
Score = 47.0 bits (110), Expect = 2e-05
Identities = 57/217 (26%), Positives = 84/217 (38%), Gaps = 32/217 (14%)
Query: 54 GSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKK------EKKKSGRYSSS 107
G K + +K ++ K EL + EK +S +K K EKK+ S
Sbjct: 1004 GEKKSKKIRDKTSKK-KDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKS 1062
Query: 108 SSSSSDSSSSSSDSEDEDKKQ------GKRRKK-----------KKNRSHKSSESSMSET 150
S D SSS D+E K+ KR K+ K+N S SS S+
Sbjct: 1063 SRKRQDCSSS--DTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDA 1120
Query: 151 ESDSKDSLKKKK----KSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRA 206
E S+D+ KKK+ K K KEK L K D ++S S S+ E ++
Sbjct: 1121 EESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQAD--ITSSSSSDIEDDDQNSI 1178
Query: 207 KKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSS 243
+ S E++ K + H + +A S S
Sbjct: 1179 GEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKS 1215
Score = 46.2 bits (108), Expect = 3e-05
Identities = 49/237 (20%), Positives = 101/237 (42%), Gaps = 44/237 (18%)
Query: 50 KKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQR-KKKEKKKSGRYSSSS 108
++KK K L + K + + EK+ K G SS K+ +R + +E++ ++
Sbjct: 1051 REKKRCKLLGKSSRKRQDCSSSDTEKYSMKE-DGCNSSDKRLKRIELRERRNLSSKRNTK 1109
Query: 109 SSSSDSSSSSSDSEDEDKKQGKRR-----------KKKKNRSHKSSESSMSETESDSKDS 157
S SSSS ++ ED K+ K+R +KK+N S++ ++ S S
Sbjct: 1110 EIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSD 1169
Query: 158 LKKKKKSK--DGTEKEKDIKGLSKKRKMYSE--------DKPLS---------------- 191
++ ++ +G+ E+ IK +++ + S D+ LS
Sbjct: 1170 IEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDP 1229
Query: 192 SESLSESEYIEEVRA-----KKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSS 243
+++ +EE++A + S +E E+ ++T K+ + ++ K + S S
Sbjct: 1230 ENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSES 1286
Score = 43.9 bits (102), Expect = 1e-04
Identities = 43/205 (20%), Positives = 85/205 (41%), Gaps = 11/205 (5%)
Query: 53 KGSKALAEFEEKMNENWKKELEKHREKLLSGS-ESSSKKRQRKKKEKKKSGRYSSSSSSS 111
+G K L +E +++ +++ E+ G+ + + + + + KK +S+
Sbjct: 825 QGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVD 884
Query: 112 SDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKK----------K 161
S S + E +K + ++K K+ K+ + ++ LKK K
Sbjct: 885 KLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDK 944
Query: 162 KKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEK 221
K+SK GTE++K KK + SS+ + EE+ K + + T+
Sbjct: 945 KQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDG 1004
Query: 222 TKKKKKHKKHSKKKKKKAASSSPDS 246
KK KK + + KKK + + + S
Sbjct: 1005 EKKSKKIRDKTSKKKDELSDYAEKS 1029
Score = 42.7 bits (99), Expect = 3e-04
Identities = 48/218 (22%), Positives = 90/218 (41%), Gaps = 22/218 (10%)
Query: 43 EVKEQLEKKKKGSKA------LAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKK 96
E++++L KK++ S + L+ E+ +++ + +EK + KK Q
Sbjct: 865 ELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLS 924
Query: 97 EKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETES---- 152
+ + S +S+ S E+KK+ KKK + + ESS TE
Sbjct: 925 DIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPER 984
Query: 153 -----DSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAK 207
K + K + DG +K K I+ + K+K E + +S + + + K
Sbjct: 985 EEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKK--DELSDYAEKSTGKGDSCDSSEDK 1042
Query: 208 KKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSSPD 245
K K+ A + KK+ K S +K++ +SS +
Sbjct: 1043 KSKNG-----AYGREKKRCKLLGKSSRKRQDCSSSDTE 1075
Score = 42.0 bits (97), Expect = 5e-04
Identities = 43/183 (23%), Positives = 75/183 (40%), Gaps = 24/183 (13%)
Query: 74 EKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGK--- 130
++ R+ SGS+ +KK K K S + S+SS+ S+ E E K K
Sbjct: 740 KRKRKSSTSGSDFDTKKG----KSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGA 795
Query: 131 -RRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSE--- 186
R KK+ + K +SS E S + K K E D ++R+ +S
Sbjct: 796 ARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEG 855
Query: 187 --DK-----------PLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSK 233
DK P ++ + ++ ++++ K++ + + +TK+K KH K
Sbjct: 856 TVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKT 915
Query: 234 KKK 236
KK
Sbjct: 916 CKK 918
Score = 41.6 bits (96), Expect = 6e-04
Identities = 44/195 (22%), Positives = 79/195 (40%), Gaps = 22/195 (11%)
Query: 67 ENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDK 126
EN E E L ES ++ R K + ++ +S+SD + + E +
Sbjct: 594 ENSDNEHLVENEVSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSDEECNETVKEKQKL 653
Query: 127 KQGKRRKKKKNRS---------HKSSESSMSETESDSKDS------LKKKKKSKDGTEKE 171
R+K K+N S +K +S SET + DS LK+ + + +
Sbjct: 654 SVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSD 713
Query: 172 KDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKH 231
DI + K + K + + ++ + K+K S+ + T+K K K
Sbjct: 714 TDINEIHTNHKTLYDLKTQAGKD-------DKGKRKRKSSTSGSDFDTKKGKSAKSSIIS 766
Query: 232 SKKKKKKAASSSPDS 246
KK++ ++ SS+ DS
Sbjct: 767 KKKRQTQSESSNYDS 781
Score = 37.0 bits (84), Expect = 0.016
Identities = 58/264 (21%), Positives = 106/264 (40%), Gaps = 32/264 (12%)
Query: 5 DNRVAYMNPIAMARSRGPIQSSGPTIQDYLNRPRPTW-------EEVKEQLEKKKKGSKA 57
DN N +++ ++ S L RP T EE E +++K+K S
Sbjct: 597 DNEHLVENEVSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSDEECNETVKEKQKLSVP 656
Query: 58 LAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEK-----KKSGRYSSSSSSSS 112
+ + +++ + + ++ + L S+ S Q ++ K+ R S SSSS
Sbjct: 657 VRKKDKRNSSD--SAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMSHSSSS-- 712
Query: 113 DSSSSSSDSE-----DEDKKQGKRRKKKKNRSHKSSESSMSETESDS-KDSLKKKKK--- 163
D+ + + D + GK K K+ R +S S + S K S+ KKK
Sbjct: 713 DTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQT 772
Query: 164 ----SKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKAT 219
S +E EK+IK +SK + K + + +S E KK + +
Sbjct: 773 QSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDS---SEDEKHSKKGMDNQGHKN 829
Query: 220 EKTKKKKKHKKHSKKKKKKAASSS 243
KT ++ +K++++ SS+
Sbjct: 830 LKTSQEGSSDDAERKQERETFSSA 853
Score = 32.3 bits (72), Expect = 0.39
Identities = 26/88 (29%), Positives = 40/88 (45%), Gaps = 7/88 (7%)
Query: 107 SSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKD 166
+S S S S SSD + KK+GK+ K K S SS S +++D + +S+
Sbjct: 1874 ASDSDETSMSLSSDDYTKKKKKGKKGK-------KDSSSSGSGSDNDVEVIKVWNSRSRG 1926
Query: 167 GTEKEKDIKGLSKKRKMYSEDKPLSSES 194
G E D G + + E+ +S S
Sbjct: 1927 GGEGNVDETGNNPSVSLKLEESKATSSS 1954
Score = 31.2 bits (69), Expect = 0.87
Identities = 26/97 (26%), Positives = 43/97 (44%), Gaps = 12/97 (12%)
Query: 65 MNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDS--- 121
MN+N K +SGS S+S + K+E S S SS SS S +
Sbjct: 40 MNQNTDK---------ISGSGSNSDMMENSKEEGTSSSEKSKSSGSSRSKRKPSIVTKYV 90
Query: 122 EDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSL 158
E +D+K ++ S+++SE+ ++ +D L
Sbjct: 91 ESDDEKPLDDETVNEDASNENSENDITMQSLPKEDGL 127
Score = 29.6 bits (65), Expect = 2.5
Identities = 23/94 (24%), Positives = 39/94 (41%), Gaps = 12/94 (12%)
Query: 104 YSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKK 163
+SS S + S + +++ DK G S S M E + S +K K
Sbjct: 24 HSSEESEETSSPPRLAMNQNTDKISG-----------SGSNSDMMENSKEEGTSSSEKSK 72
Query: 164 SKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSE 197
S G+ + K + K ++KPL E+++E
Sbjct: 73 S-SGSSRSKRKPSIVTKYVESDDEKPLDDETVNE 105
Score = 28.9 bits (63), Expect = 4.3
Identities = 40/175 (22%), Positives = 76/175 (43%), Gaps = 16/175 (9%)
Query: 32 DYLNRPRPTWEE--VKEQLEKK-KKGSKALAEFEEKMNENWKKELEK-----HREKLLSG 83
D +N+ + T E + + E K +KG K A ++ ++++ K K H + +
Sbjct: 383 DAVNKEKNTKEHKVIDAKFETKARKGEKPCALEKKDISKSEAKLSRKQVDSEHMHQNVPT 442
Query: 84 SESSSKKR---QRKKKEKKKSGRYSSSSSSSSDS----SSSSSDSEDEDKKQGKRRKKKK 136
E + K + KK ++K+ +Y +++S S SS ED + + +
Sbjct: 443 EEQRTNKSTGGEHKKSDRKEEPQYEPANTSEDLDMDIVSVPSSVPEDIFENLETAMEVQS 502
Query: 137 NRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLS 191
+ H+ SS +E E +S S+K SKD K +++Y + P+S
Sbjct: 503 SVDHQGDGSSGTEQEVESS-SVKLNISSKDNRGGIKSKTTAKVTKELYVKLTPVS 556
Score = 28.9 bits (63), Expect = 4.3
Identities = 26/76 (34%), Positives = 35/76 (46%), Gaps = 12/76 (15%)
Query: 84 SESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSS 143
S S S KKK+K K G+ SS SS S SD++ E K +RS
Sbjct: 1881 SMSLSSDDYTKKKKKGKKGKKDSS------SSGSGSDNDVEVIKVW------NSRSRGGG 1928
Query: 144 ESSMSETESDSKDSLK 159
E ++ ET ++ SLK
Sbjct: 1929 EGNVDETGNNPSVSLK 1944
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 70.1 bits (170), Expect = 2e-12
Identities = 57/212 (26%), Positives = 102/212 (48%), Gaps = 17/212 (8%)
Query: 43 EVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSG 102
++++Q E G++ L E EE + + K +++ + G + S K R + K+K +
Sbjct: 1004 KMEQQYESSSDGTEKLPEREEICH--FPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELS 1061
Query: 103 RYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKK---NRSHKSSESSMSETES-----DS 154
Y+ S+ DS SS D + ++ G+ +K+ K S K + S S+TE D
Sbjct: 1062 DYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDG 1121
Query: 155 KDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEE 214
+S K+ K + E+ + LS KR + + S S S++E E KKK+ +
Sbjct: 1122 CNSSDKRLKRIELRER----RNLSSKR---NTKEIQSGSSSSDAEESSEDNKKKKQRTSS 1174
Query: 215 REKATEKTKKKKKHKKHSKKKKKKAASSSPDS 246
++KA +KK+ + S K+K+ +SS S
Sbjct: 1175 KKKAVIVKEKKRNSLRTSTKRKQADITSSSSS 1206
Score = 64.7 bits (156), Expect = 7e-11
Identities = 61/219 (27%), Positives = 100/219 (45%), Gaps = 39/219 (17%)
Query: 35 NRPRPTWEEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRK 94
N P EE K Q+ S++ ++ EE ++ L +H+ + G KK + K
Sbjct: 1307 NEENPGDEEAKNQVN-----SESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPK 1361
Query: 95 K-KEKKKSGRYSSSSSSSSDS-------SSSSSDSEDEDKKQGKRRKK----KKNRSHKS 142
+ KE K R SS S DS S S+SEDE + + + KK + RS+K
Sbjct: 1362 EHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQ 1421
Query: 143 ---------SESSMSETESDSKDSLKKKKKSKDGTEKEKDI------------KGLSKKR 181
E S SE +S+S++ ++K++ ++ E+E++ KG K R
Sbjct: 1422 KKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIR 1481
Query: 182 KMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATE 220
K+ +DK L +E+ + + EE R + + EREK E
Sbjct: 1482 KILKDDK-LRTETQNALKEEEERRKRIAEREREREKLRE 1519
Score = 53.5 bits (127), Expect = 2e-07
Identities = 46/163 (28%), Positives = 79/163 (48%), Gaps = 35/163 (21%)
Query: 115 SSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSM----SETESDSKDSLK----------- 159
SS S D++ ++GK+R K+N + E + SE++SDS++S K
Sbjct: 1285 SSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHK 1344
Query: 160 ---------KKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLS-------SESLSESEYIEE 203
++KK+K ++ K++KG +RK+ SED S SE +SESE +
Sbjct: 1345 LTVSDGESGEEKKTKP--KEHKEVKG-RNRRKVSSEDSEDSDFQESGVSEEVSESEDEQR 1401
Query: 204 VRAKKKKSSE-EREKATEKTKKKKKHKKHSKKKKKKAASSSPD 245
R + K +E E + + K KKK++ K + + S+S +
Sbjct: 1402 PRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEE 1444
Score = 53.5 bits (127), Expect = 2e-07
Identities = 42/186 (22%), Positives = 87/186 (46%), Gaps = 5/186 (2%)
Query: 25 SSGPTIQDYLNRPRPTWEEVKEQLEKKKKGSKALAEFEEK-MNENWKKELEKHREKLLSG 83
S G + ++ +P+ E K ++F+E ++E + ++ R + S
Sbjct: 1348 SDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSA 1407
Query: 84 SESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSS 143
++ ++ QR K+KKK R SSS++ S+S E+E++K+ + ++++ +
Sbjct: 1408 KKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSE--EEEEEKEEEEEEEEEEEEEEED 1465
Query: 144 ESSMSETESDSKDSLKK-KKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIE 202
E+ S++ + ++K K K TE + +K ++RK +E + E L E IE
Sbjct: 1466 ENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAE-REREREKLREVIEIE 1524
Query: 203 EVRAKK 208
+ K
Sbjct: 1525 DASPTK 1530
Score = 48.5 bits (114), Expect = 5e-06
Identities = 56/245 (22%), Positives = 108/245 (44%), Gaps = 60/245 (24%)
Query: 50 KKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSS 109
K+ + + ++ EE +N KK+ +SSKK+ KEKK++ +S+
Sbjct: 1147 KEIQSGSSSSDAEESSEDNKKKK-----------QRTSSKKKAVIVKEKKRNSLRTSTKR 1195
Query: 110 SSSD-SSSSSSDSEDEDKK---QGKRRKKKKN--------RSH-----KSSESSMSET-- 150
+D +SSSSSD ED+D+ +G ++K SH S + ++S++
Sbjct: 1196 KQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVP 1255
Query: 151 --------ESDSKDSLKKK----------KKSKDGTEKEKDIKGLSKKRKMYSED----- 187
++D ++ + KK +DG+ ++ +G + K E+
Sbjct: 1256 VTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEE 1315
Query: 188 --KPLSSESLSESEYIEEVR-----AKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAA 240
++SES S+SE ++ R + K + + E EK K K+HK+ + ++K +
Sbjct: 1316 AKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVS 1375
Query: 241 SSSPD 245
S +
Sbjct: 1376 SEDSE 1380
Score = 47.0 bits (110), Expect = 2e-05
Identities = 57/217 (26%), Positives = 84/217 (38%), Gaps = 32/217 (14%)
Query: 54 GSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKK------EKKKSGRYSSS 107
G K + +K ++ K EL + EK +S +K K EKK+ S
Sbjct: 1042 GEKKSKKIRDKTSKK-KDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKS 1100
Query: 108 SSSSSDSSSSSSDSEDEDKKQ------GKRRKK-----------KKNRSHKSSESSMSET 150
S D SSS D+E K+ KR K+ K+N S SS S+
Sbjct: 1101 SRKRQDCSSS--DTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDA 1158
Query: 151 ESDSKDSLKKKK----KSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRA 206
E S+D+ KKK+ K K KEK L K D ++S S S+ E ++
Sbjct: 1159 EESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQAD--ITSSSSSDIEDDDQNSI 1216
Query: 207 KKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSS 243
+ S E++ K + H + +A S S
Sbjct: 1217 GEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKS 1253
Score = 46.2 bits (108), Expect = 3e-05
Identities = 49/237 (20%), Positives = 101/237 (42%), Gaps = 44/237 (18%)
Query: 50 KKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQR-KKKEKKKSGRYSSSS 108
++KK K L + K + + EK+ K G SS K+ +R + +E++ ++
Sbjct: 1089 REKKRCKLLGKSSRKRQDCSSSDTEKYSMKE-DGCNSSDKRLKRIELRERRNLSSKRNTK 1147
Query: 109 SSSSDSSSSSSDSEDEDKKQGKRR-----------KKKKNRSHKSSESSMSETESDSKDS 157
S SSSS ++ ED K+ K+R +KK+N S++ ++ S S
Sbjct: 1148 EIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSD 1207
Query: 158 LKKKKKSK--DGTEKEKDIKGLSKKRKMYSE--------DKPLS---------------- 191
++ ++ +G+ E+ IK +++ + S D+ LS
Sbjct: 1208 IEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDP 1267
Query: 192 SESLSESEYIEEVRA-----KKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSS 243
+++ +EE++A + S +E E+ ++T K+ + ++ K + S S
Sbjct: 1268 ENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSES 1324
Score = 43.9 bits (102), Expect = 1e-04
Identities = 43/205 (20%), Positives = 85/205 (41%), Gaps = 11/205 (5%)
Query: 53 KGSKALAEFEEKMNENWKKELEKHREKLLSGS-ESSSKKRQRKKKEKKKSGRYSSSSSSS 111
+G K L +E +++ +++ E+ G+ + + + + + KK +S+
Sbjct: 863 QGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVD 922
Query: 112 SDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKK----------K 161
S S + E +K + ++K K+ K+ + ++ LKK K
Sbjct: 923 KLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDK 982
Query: 162 KKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEK 221
K+SK GTE++K KK + SS+ + EE+ K + + T+
Sbjct: 983 KQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDG 1042
Query: 222 TKKKKKHKKHSKKKKKKAASSSPDS 246
KK KK + + KKK + + + S
Sbjct: 1043 EKKSKKIRDKTSKKKDELSDYAEKS 1067
Score = 42.7 bits (99), Expect = 3e-04
Identities = 48/218 (22%), Positives = 90/218 (41%), Gaps = 22/218 (10%)
Query: 43 EVKEQLEKKKKGSKA------LAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKK 96
E++++L KK++ S + L+ E+ +++ + +EK + KK Q
Sbjct: 903 ELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLS 962
Query: 97 EKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETES---- 152
+ + S +S+ S E+KK+ KKK + + ESS TE
Sbjct: 963 DIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPER 1022
Query: 153 -----DSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAK 207
K + K + DG +K K I+ + K+K E + +S + + + K
Sbjct: 1023 EEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKK--DELSDYAEKSTGKGDSCDSSEDK 1080
Query: 208 KKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSSPD 245
K K+ A + KK+ K S +K++ +SS +
Sbjct: 1081 KSKNG-----AYGREKKRCKLLGKSSRKRQDCSSSDTE 1113
Score = 42.0 bits (97), Expect = 5e-04
Identities = 43/183 (23%), Positives = 75/183 (40%), Gaps = 24/183 (13%)
Query: 74 EKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGK--- 130
++ R+ SGS+ +KK K K S + S+SS+ S+ E E K K
Sbjct: 778 KRKRKSSTSGSDFDTKKG----KSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGA 833
Query: 131 -RRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSE--- 186
R KK+ + K +SS E S + K K E D ++R+ +S
Sbjct: 834 ARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEG 893
Query: 187 --DK-----------PLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSK 233
DK P ++ + ++ ++++ K++ + + +TK+K KH K
Sbjct: 894 TVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKT 953
Query: 234 KKK 236
KK
Sbjct: 954 CKK 956
Score = 41.6 bits (96), Expect = 6e-04
Identities = 44/195 (22%), Positives = 79/195 (40%), Gaps = 22/195 (11%)
Query: 67 ENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDK 126
EN E E L ES ++ R K + ++ +S+SD + + E +
Sbjct: 632 ENSDNEHLVENEVSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSDEECNETVKEKQKL 691
Query: 127 KQGKRRKKKKNRS---------HKSSESSMSETESDSKDS------LKKKKKSKDGTEKE 171
R+K K+N S +K +S SET + DS LK+ + + +
Sbjct: 692 SVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSD 751
Query: 172 KDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKH 231
DI + K + K + + ++ + K+K S+ + T+K K K
Sbjct: 752 TDINEIHTNHKTLYDLKTQAGKD-------DKGKRKRKSSTSGSDFDTKKGKSAKSSIIS 804
Query: 232 SKKKKKKAASSSPDS 246
KK++ ++ SS+ DS
Sbjct: 805 KKKRQTQSESSNYDS 819
Score = 37.0 bits (84), Expect = 0.016
Identities = 58/264 (21%), Positives = 106/264 (40%), Gaps = 32/264 (12%)
Query: 5 DNRVAYMNPIAMARSRGPIQSSGPTIQDYLNRPRPTW-------EEVKEQLEKKKKGSKA 57
DN N +++ ++ S L RP T EE E +++K+K S
Sbjct: 635 DNEHLVENEVSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSDEECNETVKEKQKLSVP 694
Query: 58 LAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEK-----KKSGRYSSSSSSSS 112
+ + +++ + + ++ + L S+ S Q ++ K+ R S SSSS
Sbjct: 695 VRKKDKRNSSD--SAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMSHSSSS-- 750
Query: 113 DSSSSSSDSE-----DEDKKQGKRRKKKKNRSHKSSESSMSETESDS-KDSLKKKKK--- 163
D+ + + D + GK K K+ R +S S + S K S+ KKK
Sbjct: 751 DTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQT 810
Query: 164 ----SKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKAT 219
S +E EK+IK +SK + K + + +S E KK + +
Sbjct: 811 QSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDS---SEDEKHSKKGMDNQGHKN 867
Query: 220 EKTKKKKKHKKHSKKKKKKAASSS 243
KT ++ +K++++ SS+
Sbjct: 868 LKTSQEGSSDDAERKQERETFSSA 891
Score = 32.3 bits (72), Expect = 0.39
Identities = 26/88 (29%), Positives = 40/88 (45%), Gaps = 7/88 (7%)
Query: 107 SSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKD 166
+S S S S SSD + KK+GK+ K K S SS S +++D + +S+
Sbjct: 1912 ASDSDETSMSLSSDDYTKKKKKGKKGK-------KDSSSSGSGSDNDVEVIKVWNSRSRG 1964
Query: 167 GTEKEKDIKGLSKKRKMYSEDKPLSSES 194
G E D G + + E+ +S S
Sbjct: 1965 GGEGNVDETGNNPSVSLKLEESKATSSS 1992
Score = 32.0 bits (71), Expect = 0.51
Identities = 32/136 (23%), Positives = 56/136 (41%), Gaps = 12/136 (8%)
Query: 104 YSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKK 163
+SS S + S + +++ DK G + K +S SE S S K+K
Sbjct: 24 HSSEESEETSSPPRLAMNQNTDKISGSGSNSDMMENSKEEGTSSSEKSKSSGSSRSKRKP 83
Query: 164 S------KDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYI---EEVRAKKK---KS 211
S + EK D + +++ + + ++ +SL + I E V + K K
Sbjct: 84 SIVTKYVESDDEKPLDDETVNEDASNENSENDITMQSLPKGTVIVQPEPVLNEDKDDFKG 143
Query: 212 SEEREKATEKTKKKKK 227
E R ++ KT+ KK
Sbjct: 144 PEFRSRSKMKTENLKK 159
Score = 29.3 bits (64), Expect = 3.3
Identities = 24/87 (27%), Positives = 40/87 (45%), Gaps = 12/87 (13%)
Query: 65 MNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDS--- 121
MN+N K +SGS S+S + K+E S S SS SS S +
Sbjct: 40 MNQNTDK---------ISGSGSNSDMMENSKEEGTSSSEKSKSSGSSRSKRKPSIVTKYV 90
Query: 122 EDEDKKQGKRRKKKKNRSHKSSESSMS 148
E +D+K ++ S+++SE+ ++
Sbjct: 91 ESDDEKPLDDETVNEDASNENSENDIT 117
Score = 28.9 bits (63), Expect = 4.3
Identities = 40/175 (22%), Positives = 76/175 (43%), Gaps = 16/175 (9%)
Query: 32 DYLNRPRPTWEE--VKEQLEKK-KKGSKALAEFEEKMNENWKKELEK-----HREKLLSG 83
D +N+ + T E + + E K +KG K A ++ ++++ K K H + +
Sbjct: 421 DAVNKEKNTKEHKVIDAKFETKARKGEKPCALEKKDISKSEAKLSRKQVDSEHMHQNVPT 480
Query: 84 SESSSKKR---QRKKKEKKKSGRYSSSSSSSSDS----SSSSSDSEDEDKKQGKRRKKKK 136
E + K + KK ++K+ +Y +++S S SS ED + + +
Sbjct: 481 EEQRTNKSTGGEHKKSDRKEEPQYEPANTSEDLDMDIVSVPSSVPEDIFENLETAMEVQS 540
Query: 137 NRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLS 191
+ H+ SS +E E +S S+K SKD K +++Y + P+S
Sbjct: 541 SVDHQGDGSSGTEQEVESS-SVKLNISSKDNRGGIKSKTTAKVTKELYVKLTPVS 594
Score = 28.9 bits (63), Expect = 4.3
Identities = 26/76 (34%), Positives = 35/76 (46%), Gaps = 12/76 (15%)
Query: 84 SESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSS 143
S S S KKK+K K G+ SS SS S SD++ E K +RS
Sbjct: 1919 SMSLSSDDYTKKKKKGKKGKKDSS------SSGSGSDNDVEVIKVW------NSRSRGGG 1966
Query: 144 ESSMSETESDSKDSLK 159
E ++ ET ++ SLK
Sbjct: 1967 EGNVDETGNNPSVSLK 1982
>gi|52426743 cisplatin resistance-associated overexpressed protein
[Homo sapiens]
Length = 432
Score = 69.7 bits (169), Expect = 2e-12
Identities = 55/194 (28%), Positives = 94/194 (48%), Gaps = 17/194 (8%)
Query: 38 RPTWEEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHRE------KLLSGSESSSKKR 91
+ T EE+KE+L K+ + +++ E ++E E+ RE K E K+R
Sbjct: 224 KATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKER 283
Query: 92 QRKKKEKKKSGRYSSSSSSSSDSSSSSSD----SEDEDKKQGKRRKKKKNRSHKSSE--- 144
R ++ +K+S S SS +SD S S S ++++ + R ++++RSH SE
Sbjct: 284 ARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKH 343
Query: 145 --SSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIE 202
S S S+D K +SK ++E+D K +K K S+DK S +S S + E
Sbjct: 344 RSRSRDRRRSKSRDRKSYKHRSK-SRDREQDRKS-KEKEKRGSDDKKSSVKSGSREKQSE 401
Query: 203 EVRAKKKKSSEERE 216
+ + K+S + E
Sbjct: 402 DTNTESKESDTKNE 415
Score = 53.1 bits (126), Expect = 2e-07
Identities = 36/176 (20%), Positives = 83/176 (47%), Gaps = 13/176 (7%)
Query: 70 KKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQG 129
K +E+ +EKL +E + + KK+++++ R + + E + +++
Sbjct: 224 KATVEELKEKLRKRTEEPDRDERLKKEKQEREER-------EKEREREREERERKRRREE 276
Query: 130 KRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKP 189
+ R+K++ R + + S S + S+ S ++ +S+D ++R+ S D+
Sbjct: 277 EEREKERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRS-----RERRRSRSRDR- 330
Query: 190 LSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSSPD 245
S S SE R++ ++ S+ R++ + K + K + ++ +K K+K S D
Sbjct: 331 RRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDD 386
Score = 42.4 bits (98), Expect = 4e-04
Identities = 26/123 (21%), Positives = 58/123 (47%), Gaps = 4/123 (3%)
Query: 119 SDSEDEDKKQGKRRK---KKKNRSHKSSESSMSETESDSKDS-LKKKKKSKDGTEKEKDI 174
+ S +D GK+ K K + E TE +D LKK+K+ ++ EKE++
Sbjct: 204 AQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKERER 263
Query: 175 KGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKK 234
+ ++RK E++ E + E + R++ + SS ++ +++ K+ + ++
Sbjct: 264 EREERERKRRREEEEREKERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERR 323
Query: 235 KKK 237
+ +
Sbjct: 324 RSR 326
Score = 39.3 bits (90), Expect = 0.003
Identities = 33/139 (23%), Positives = 59/139 (42%), Gaps = 3/139 (2%)
Query: 17 ARSRGPIQSSGPTIQDYLNRPRPTWEEVKEQLEKKKKGSKALAEFEEKMNENWK-KELEK 75
+RSR ++S + R E + + ++ S++ E K + + K
Sbjct: 295 SRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSK 354
Query: 76 HREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKK 135
R++ S S+ R++ +K K+K R S SS S S SED + + +
Sbjct: 355 SRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTE--SKESDT 412
Query: 136 KNRSHKSSESSMSETESDS 154
KN + +SE SE ++ S
Sbjct: 413 KNEVNGTSEDIKSEGDTQS 431
>gi|19923485 cisplatin resistance-associated overexpressed protein
[Homo sapiens]
Length = 432
Score = 69.7 bits (169), Expect = 2e-12
Identities = 55/194 (28%), Positives = 94/194 (48%), Gaps = 17/194 (8%)
Query: 38 RPTWEEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHRE------KLLSGSESSSKKR 91
+ T EE+KE+L K+ + +++ E ++E E+ RE K E K+R
Sbjct: 224 KATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKER 283
Query: 92 QRKKKEKKKSGRYSSSSSSSSDSSSSSSD----SEDEDKKQGKRRKKKKNRSHKSSE--- 144
R ++ +K+S S SS +SD S S S ++++ + R ++++RSH SE
Sbjct: 284 ARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKH 343
Query: 145 --SSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIE 202
S S S+D K +SK ++E+D K +K K S+DK S +S S + E
Sbjct: 344 RSRSRDRRRSKSRDRKSYKHRSK-SRDREQDRKS-KEKEKRGSDDKKSSVKSGSREKQSE 401
Query: 203 EVRAKKKKSSEERE 216
+ + K+S + E
Sbjct: 402 DTNTESKESDTKNE 415
Score = 53.1 bits (126), Expect = 2e-07
Identities = 36/176 (20%), Positives = 83/176 (47%), Gaps = 13/176 (7%)
Query: 70 KKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQG 129
K +E+ +EKL +E + + KK+++++ R + + E + +++
Sbjct: 224 KATVEELKEKLRKRTEEPDRDERLKKEKQEREER-------EKEREREREERERKRRREE 276
Query: 130 KRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKP 189
+ R+K++ R + + S S + S+ S ++ +S+D ++R+ S D+
Sbjct: 277 EEREKERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRS-----RERRRSRSRDR- 330
Query: 190 LSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSSPD 245
S S SE R++ ++ S+ R++ + K + K + ++ +K K+K S D
Sbjct: 331 RRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDD 386
Score = 42.4 bits (98), Expect = 4e-04
Identities = 26/123 (21%), Positives = 58/123 (47%), Gaps = 4/123 (3%)
Query: 119 SDSEDEDKKQGKRRK---KKKNRSHKSSESSMSETESDSKDS-LKKKKKSKDGTEKEKDI 174
+ S +D GK+ K K + E TE +D LKK+K+ ++ EKE++
Sbjct: 204 AQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKERER 263
Query: 175 KGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKK 234
+ ++RK E++ E + E + R++ + SS ++ +++ K+ + ++
Sbjct: 264 EREERERKRRREEEEREKERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERR 323
Query: 235 KKK 237
+ +
Sbjct: 324 RSR 326
Score = 39.3 bits (90), Expect = 0.003
Identities = 33/139 (23%), Positives = 59/139 (42%), Gaps = 3/139 (2%)
Query: 17 ARSRGPIQSSGPTIQDYLNRPRPTWEEVKEQLEKKKKGSKALAEFEEKMNENWK-KELEK 75
+RSR ++S + R E + + ++ S++ E K + + K
Sbjct: 295 SRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSK 354
Query: 76 HREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKK 135
R++ S S+ R++ +K K+K R S SS S S SED + + +
Sbjct: 355 SRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTE--SKESDT 412
Query: 136 KNRSHKSSESSMSETESDS 154
KN + +SE SE ++ S
Sbjct: 413 KNEVNGTSEDIKSEGDTQS 431
>gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain
containing B [Homo sapiens]
Length = 546
Score = 67.4 bits (163), Expect = 1e-11
Identities = 58/255 (22%), Positives = 99/255 (38%), Gaps = 32/255 (12%)
Query: 18 RSRGPIQSSGPTIQDYLNRPRPTWEE------VKEQLEKKKKGSKALAEFEEKMNENWKK 71
RSR P +S P +R R E +LE++K+ + E +E+ E +
Sbjct: 259 RSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKEREKERRRS 318
Query: 72 E-----LEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDK 126
LE+ R S S + R R + +K R ++ D DK
Sbjct: 319 RSIDRGLERRR------SRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDK 372
Query: 127 KQGKRRKKKKNRSHKSSESSMSETE---------------SDSKDSLKKKKKSKDGTEKE 171
++G R+K++ RS + S+ S E D K KK+KK +E
Sbjct: 373 ERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRE 432
Query: 172 KDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKH 231
+ + S+ R + S E S+ + + ++ K+ S + + K KK+
Sbjct: 433 RKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSP 492
Query: 232 SKKKKKKAASSSPDS 246
SK+K +K + S S
Sbjct: 493 SKEKSRKRSRSKERS 507
Score = 60.5 bits (145), Expect = 1e-09
Identities = 44/188 (23%), Positives = 86/188 (45%), Gaps = 26/188 (13%)
Query: 42 EEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKS 101
E+ +E+ ++ K ++ E EEK ++ K + +HR+ + SKK ++ + + +
Sbjct: 379 EKERERSRERSKEQRSRGEVEEKKHKEDKDD-RRHRD-----DKRDSKKEKKHSRSRSRE 432
Query: 102 GRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKK 161
++ S S S + S S S+++ K K+K N+ +S + DS++K
Sbjct: 433 RKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRT-------DSVEKS 485
Query: 162 KKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEK 221
KK + KEK K K + + D S+S +S+ K R ++ E+
Sbjct: 486 KKREHSPSKEKSRKRSRSKERSHKRD---HSDSKDQSD----------KHDRRRSQSIEQ 532
Query: 222 TKKKKKHK 229
++K+HK
Sbjct: 533 ESQEKQHK 540
Score = 58.5 bits (140), Expect = 5e-09
Identities = 42/194 (21%), Positives = 88/194 (45%), Gaps = 9/194 (4%)
Query: 45 KEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRY 104
+E+ ++ ++G + +++++ +KE E+ RE+ S + ++K KE K R+
Sbjct: 354 REREKENERGRRRDRDYDKERGNEREKERERSRERSKE-QRSRGEVEEKKHKEDKDDRRH 412
Query: 105 SSSSSSSSDSSSSSSDSEDEDKKQGKRRKK---KKNRSHKSSESSMSETESDSKDSLKKK 161
S S E K + + R + K++RS +SS + ES K +
Sbjct: 413 RDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSN---- 468
Query: 162 KKSKDGTEKEKDIKGLSKKRK-MYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATE 220
K+S+ G++ D SKKR+ S++K E + + K +S + + ++
Sbjct: 469 KRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQ 528
Query: 221 KTKKKKKHKKHSKK 234
+++ + K+H K
Sbjct: 529 SIEQESQEKQHKNK 542
Score = 56.6 bits (135), Expect = 2e-08
Identities = 43/213 (20%), Positives = 94/213 (44%), Gaps = 15/213 (7%)
Query: 37 PRPTWEEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSS-KKRQRKK 95
P P + + +Q++ + + K K + +E+++H E+ S S S R+ +
Sbjct: 222 PVPVQKNIDQQIKTRPRKIK-------KDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPR 274
Query: 96 KEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSK 155
+ + +S SSS D +++ K R+K++ RS +S + + S S+
Sbjct: 275 RSRSRSHHREGHGSSSFDRELEREKERQRLEREAKEREKERRRS-RSIDRGLERRRSRSR 333
Query: 156 DSLKKKKKSKD------GTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKK 209
+ + + +S+D ++E++ + +R+ DK +E E E E +++
Sbjct: 334 ERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQR 393
Query: 210 KSSEEREKATEKTKKKKKHKKHSKKKKKKAASS 242
E EK ++ K ++H+ + KK+ S
Sbjct: 394 SRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHS 426
Score = 54.3 bits (129), Expect = 1e-07
Identities = 41/199 (20%), Positives = 86/199 (43%), Gaps = 8/199 (4%)
Query: 50 KKKKGSKALAEFE-EKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSS 108
+ +KG + + E EK NE ++ ++ +K ++R R++ ++++S
Sbjct: 343 RDRKGDRRDRDREREKENERGRRR-DRDYDKERGNEREKERERSRERSKEQRSRGEVEEK 401
Query: 109 SSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGT 168
D + D K+ K+ + ++R K S S S K+K SK
Sbjct: 402 KHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKN 461
Query: 169 E-KEKDIKGLSKKRKMYSEDKPLSSESLSESEYI-EEVRAKKKKSSEEREKATEKTKKKK 226
E KEK +K+ + S+ + S E + E+ + +++K+ S+ER + + K
Sbjct: 462 ESKEKS----NKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKD 517
Query: 227 KHKKHSKKKKKKAASSSPD 245
+ KH +++ + S +
Sbjct: 518 QSDKHDRRRSQSIEQESQE 536
Score = 41.2 bits (95), Expect = 8e-04
Identities = 25/121 (20%), Positives = 55/121 (45%), Gaps = 8/121 (6%)
Query: 35 NRPRPTWEEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGS-------ESS 87
+R R + + + + G ++ + +EK +++ + EK ++ SGS E S
Sbjct: 426 SRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKS 485
Query: 88 SKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKR-RKKKKNRSHKSSESS 146
K+ KEK + S S D S S S+ D+++ + ++ + + HK+ + +
Sbjct: 486 KKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKDET 545
Query: 147 M 147
+
Sbjct: 546 V 546
>gi|42560244 peptidylprolyl isomerase G [Homo sapiens]
Length = 754
Score = 67.0 bits (162), Expect = 1e-11
Identities = 55/191 (28%), Positives = 92/191 (48%), Gaps = 22/191 (11%)
Query: 54 GSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKK-KSGRYSSSSSSSS 112
G + + E E + + K + R +LS E K + +K+++K+ KS SSSSSS S
Sbjct: 147 GQEVVREIENQKTDAASKPFAEVR--ILSCGELIPKSKVKKEEKKRHKSSSSSSSSSSDS 204
Query: 113 DSSS---SSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTE 169
DSSS SSSDS D + ++ KK+K + K+S E KK+KKSK
Sbjct: 205 DSSSDSQSSSDSSDSESATEEKSKKRKKKHRKNSRKHKKEK--------KKRKKSKKSAS 256
Query: 170 KEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHK 229
E + + L E +P S+ E I E R +KS + ++ K +++++ +
Sbjct: 257 SESEAENL--------EAQPQSTVRPEEIPPIPENRFLMRKSPPKADEKERKNRERERER 308
Query: 230 KHSKKKKKKAA 240
+ + + A+
Sbjct: 309 ECNPPNSQPAS 319
Score = 63.2 bits (152), Expect = 2e-10
Identities = 50/246 (20%), Positives = 100/246 (40%), Gaps = 31/246 (12%)
Query: 9 AYMNPIAMARSRGPIQSSGPTIQDYLNRPR-----------PTWEEVKEQLEKKKKGSKA 57
+Y + + RS I+ GP +R R P W + ++ ++ + S
Sbjct: 319 SYQRRLLVTRSGRKIKGRGPRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSS-- 376
Query: 58 LAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSS 117
E W K + ++ S + ++RK + + S S + ++
Sbjct: 377 --------GERWIKGDKSELNEIKENQRSPVRVKERKITDHRN---VSESPNRKNEKEKK 425
Query: 118 SSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGL 177
D + K++ RR +K+ +K+ ++++S SK K K K +D +
Sbjct: 426 VKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRNE---- 481
Query: 178 SKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKK 237
+++M S K E++ E E + + K ++ S +EK+ + K +H HSK K+K
Sbjct: 482 --EKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEH-DHSKSKEK 538
Query: 238 KAASSS 243
+ S
Sbjct: 539 DRRAQS 544
Score = 60.8 bits (146), Expect = 1e-09
Identities = 43/190 (22%), Positives = 87/190 (45%), Gaps = 7/190 (3%)
Query: 49 EKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSS 108
E+K + ++E + NE KK + +S+K + K + KK + S S
Sbjct: 403 ERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRS 462
Query: 109 SSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGT 168
S S S DS+ ++ + R + K R H++ + E +SDSK +++ +SK
Sbjct: 463 KSKEKSKSKERDSKHNRNEEKRMRSRSKGRDHENVKE--KEKQSDSKGKDQERSRSK--- 517
Query: 169 EKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKK-K 227
EK K ++ S + +S+ K + S S + + K +S RE++ + + ++ +
Sbjct: 518 EKSKQLESKSNEHD-HSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVR 576
Query: 228 HKKHSKKKKK 237
+ H + + +
Sbjct: 577 SRTHDRDRSR 586
Score = 56.6 bits (135), Expect = 2e-08
Identities = 48/228 (21%), Positives = 96/228 (42%), Gaps = 5/228 (2%)
Query: 20 RGPIQSSGPTIQDYLNRPRPTWEEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREK 79
R P++ I D+ N K + EKK K K+ ++ + + K + K++ K
Sbjct: 396 RSPVRVKERKITDHRNVSESP--NRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVK 453
Query: 80 LLSGSESSSK-KRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNR 138
+ S+S SK K + K KE+ + S S ++ E +KQ + K + R
Sbjct: 454 KRAKSKSRSKSKEKSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQER 513
Query: 139 SHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSES 198
S +S E++S+ D K K+K + + ++ ++K + Y+ S S S
Sbjct: 514 SRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSREC-DITKGKHSYNSRTRERSRSRDRS 572
Query: 199 EYI-EEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSSPD 245
+ + + S+E + E+ +++ + +++ S S D
Sbjct: 573 RRVRSRTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKD 620
Score = 55.8 bits (133), Expect = 3e-08
Identities = 43/202 (21%), Positives = 90/202 (44%), Gaps = 11/202 (5%)
Query: 49 EKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKE-----KKKSGR 103
E+K+ S++ E + E K+ K +++ S S+ SK+ + K E K+ R
Sbjct: 481 EEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDR 540
Query: 104 YSSSSSSSSDSSSS--SSDSEDEDKKQGKRRKKK-KNRSHKSSESSMSETESDSKDSLKK 160
+ S S D + S +S ++ + + R ++ ++R+H S E + ++
Sbjct: 541 RAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRSRSKEYHRYREQEYRR 600
Query: 161 KKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATE 220
+ +S+ + + SK R+ D S S+S ++ R ++ KSS +E +
Sbjct: 601 RGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQSRNKDKYRNQESKSSHRKENSES 660
Query: 221 KTK---KKKKHKKHSKKKKKKA 239
+ + K + H + ++KKA
Sbjct: 661 EKRMYSKSRDHNSSNNSREKKA 682
Score = 55.5 bits (132), Expect = 4e-08
Identities = 55/223 (24%), Positives = 108/223 (48%), Gaps = 29/223 (13%)
Query: 42 EEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQ----RKKKE 97
EE+ E + K+ + +EK +N +E E+ RE S+ +S +R+ R ++
Sbjct: 275 EEIPPIPENRFLMRKSPPKADEKERKN--RERERERECNPPNSQPASYQRRLLVTRSGRK 332
Query: 98 KKKSG--RYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKK----NRSHKSSESSMSETE 151
K G RY + S S S S++ +++ +R ++ + R K +S ++E +
Sbjct: 333 IKGRGPRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIK 392
Query: 152 SDSKDSLK-KKKKSKD----------GTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEY 200
+ + ++ K++K D EKEK + K K S+++ + S + +Y
Sbjct: 393 ENQRSPVRVKERKITDHRNVSESPNRKNEKEKKV----KDHKSNSKERDIRRNSEKDDKY 448
Query: 201 IEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSS 243
+V KK+ S+ R K+ EK+K K++ KH++ ++K+ S S
Sbjct: 449 KNKV--KKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRMRSRS 489
Score = 55.5 bits (132), Expect = 4e-08
Identities = 41/177 (23%), Positives = 79/177 (44%), Gaps = 7/177 (3%)
Query: 49 EKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSS 108
++ + SK + E+ E ++ + RE+ S SK R+R++++ + S R S S
Sbjct: 581 DRDRSRSKEYHRYREQ--EYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQS 638
Query: 109 SSSSD-SSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSM-SETESDSKDSLKKKKKSKD 166
+ + S S ++ + ++R K+R H SS +S + + D K K+ S+D
Sbjct: 639 RNKDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSNNSREKKADRDQSPFSKIKQSSQD 698
Query: 167 GTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTK 223
K +K ++ S +K E++++ E K KK E T++ K
Sbjct: 699 NELKSSMLKNKEDEKIRSSVEKENQKSKGQENDHVHE---KNKKFDHESSPGTDEDK 752
Score = 52.4 bits (124), Expect = 4e-07
Identities = 42/172 (24%), Positives = 80/172 (46%), Gaps = 14/172 (8%)
Query: 71 KELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGK 130
KE ++RE+ E + R R ++ + GR S S D DS ++++ +
Sbjct: 588 KEYHRYREQ-----EYRRRGRSRSRERRTPPGR-----SRSKDRRRRRRDSRSSEREESQ 637
Query: 131 RRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPL 190
R K K R+ +S S E S+S+ + K + + + ++ K + + +S+ K
Sbjct: 638 SRNKDKYRNQESKSSHRKEN-SESEKRMYSKSRDHNSSNNSREKKA-DRDQSPFSKIKQS 695
Query: 191 SSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASS 242
S ++ +S ++ +K +SS E+E +K+K ++ H K KK SS
Sbjct: 696 SQDNELKSSMLKNKEDEKIRSSVEKE--NQKSKGQENDHVHEKNKKFDHESS 745
Score = 45.4 bits (106), Expect = 4e-05
Identities = 30/98 (30%), Positives = 46/98 (46%), Gaps = 11/98 (11%)
Query: 146 SMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVR 205
S E SK ++KK+ K + S D SS+S S S+ +
Sbjct: 173 SCGELIPKSKVKKEEKKRHKSSSSSSSS-----------SSDSDSSSDSQSSSDSSDSES 221
Query: 206 AKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSS 243
A ++KS + ++K + ++K KK KK KK KK A+S S
Sbjct: 222 ATEEKSKKRKKKHRKNSRKHKKEKKKRKKSKKSASSES 259
Score = 45.1 bits (105), Expect = 6e-05
Identities = 30/84 (35%), Positives = 47/84 (55%), Gaps = 2/84 (2%)
Query: 163 KSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKT 222
KSK E++K K S S D SS+S S S+ + A ++KS + ++K + +
Sbjct: 180 KSKVKKEEKKRHKSSSSSSSS-SSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKNS 238
Query: 223 KKKKKHKKHSKKKKKKAASSSPDS 246
+K KK KK +KK KK+ASS ++
Sbjct: 239 RKHKKEKK-KRKKSKKSASSESEA 261
Score = 42.0 bits (97), Expect = 5e-04
Identities = 46/230 (20%), Positives = 91/230 (39%), Gaps = 36/230 (15%)
Query: 42 EEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKS 101
E + + + K+ SK+ K E ++ + RE ++ + S R R++ +
Sbjct: 512 ERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDR 571
Query: 102 GRYSSSSSSSSDSSSSSSDS---EDEDKKQGK-------------------RRKKKKNRS 139
R S + D S S E E +++G+ RR++ S
Sbjct: 572 SRRVRSRTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSS 631
Query: 140 HKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESE 199
+ E S S + ++ K K+ +E EK +MYS+ + +S + S +
Sbjct: 632 ER--EESQSRNKDKYRNQESKSSHRKENSESEK---------RMYSKSRDHNSSNNSREK 680
Query: 200 YIEEVR---AKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSSPDS 246
+ + +K K+SS++ E + K K+ K S +K+ S ++
Sbjct: 681 KADRDQSPFSKIKQSSQDNELKSSMLKNKEDEKIRSSVEKENQKSKGQEN 730
Score = 35.0 bits (79), Expect = 0.060
Identities = 34/146 (23%), Positives = 60/146 (41%), Gaps = 11/146 (7%)
Query: 36 RPRPTWEEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKK 95
R P + ++++ S++ +E EE + N K + + S S+KR K
Sbjct: 609 RRTPPGRSRSKDRRRRRRDSRS-SEREESQSRNKDKYRNQESKSSHRKENSESEKRMYSK 667
Query: 96 KEKKKSGRYSSSSSSSSDSS------SSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSE 149
S S + D S SS D+E + K ++ +K RS E+ S+
Sbjct: 668 SRDHNSSNNSREKKADRDQSPFSKIKQSSQDNELKSSML-KNKEDEKIRSSVEKENQKSK 726
Query: 150 TESDSKDSLKKKK---KSKDGTEKEK 172
+ + K KK +S GT+++K
Sbjct: 727 GQENDHVHEKNKKFDHESSPGTDEDK 752
>gi|4759100 splicing factor, arginine/serine-rich 11 [Homo sapiens]
Length = 484
Score = 66.6 bits (161), Expect = 2e-11
Identities = 55/219 (25%), Positives = 99/219 (45%), Gaps = 25/219 (11%)
Query: 25 SSGPTIQDYLNRPRPTWEEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGS 84
+S I++ + R R + +E KK EEK + + + R S
Sbjct: 214 TSSKEIEEAMKRVREAQSLISAAIEPDKK--------EEKRRHSRSRSRSRRRRTPSSSR 265
Query: 85 ESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSS------SSSDSEDEDKKQGKRRKKKKNR 138
S+ R R++ K R S S S S S S S+ DKK+ + ++KK+++
Sbjct: 266 HRRSRSRSRRRSHSKSRSRRRSKSPRRRRSHSRERGRRSRSTSKTRDKKK-EDKEKKRSK 324
Query: 139 SHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSES 198
+ S S+ + S S++ +++++S+ GT K K S KRK+ P + +
Sbjct: 325 TPPKSYSTARRSRSASRE--RRRRRSRSGTRSPK--KPRSPKRKLSRSPSPRRHKKEKKK 380
Query: 199 EYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKK 237
+ K++S +ERE++T K KK K +K ++K +
Sbjct: 381 D------KDKERSRDERERSTSKKKKSKDKEKDRERKSE 413
Score = 62.0 bits (149), Expect = 5e-10
Identities = 53/198 (26%), Positives = 95/198 (47%), Gaps = 11/198 (5%)
Query: 35 NRPRPTWEEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRK 94
+R R T + + + + ++ ++ + + H + S S+SK R +K
Sbjct: 255 SRRRRTPSSSRHRRSRSRSRRRSHSKSRSRRRSKSPRRRRSHSRERGRRSRSTSKTRDKK 314
Query: 95 K--KEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETES 152
K KEKK+S S S++ S S+S + + G R KK +S + +S + S
Sbjct: 315 KEDKEKKRSKTPPKSYSTARRSRSASRERRRRRSRSGTRSPKKP----RSPKRKLSRSPS 370
Query: 153 DSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSS 212
+ K+KKK KD E+ +D + S +K S+DK E SES+ ++V+ + +
Sbjct: 371 PRRHK-KEKKKDKD-KERSRDERERSTSKKKKSKDKEKDRERKSESD--KDVK-QVTRDY 425
Query: 213 EEREKATEKTKKKKKHKK 230
+E E+ + K+KK+ KK
Sbjct: 426 DEEEQGYDSEKEKKEEKK 443
Score = 59.3 bits (142), Expect = 3e-09
Identities = 49/199 (24%), Positives = 87/199 (43%), Gaps = 13/199 (6%)
Query: 53 KGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKK--KEKKKSGRYSSSSSS 110
K + E EE M + + L+S + KK ++++ + + +S R + SSS
Sbjct: 211 KSDTSSKEIEEAMKR------VREAQSLISAAIEPDKKEEKRRHSRSRSRSRRRRTPSSS 264
Query: 111 SSDSSSSSSDSEDEDKKQGKRRKK--KKNRSHKSSESSMSETESDSKDSLKKKKKSKDGT 168
S S S K + +RR K ++ RSH S + S ++D K+ K+ K
Sbjct: 265 RHRRSRSRSRRRSHSKSRSRRRSKSPRRRRSHSRERGRRSRSTSKTRDKKKEDKEKKRSK 324
Query: 169 EKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKK-SSEEREKATEKTKKKKK 227
K + R E + S S + S ++ R+ K+K S + +K KKK K
Sbjct: 325 TPPKSYSTARRSRSASRERRRRRSRSGTRSP--KKPRSPKRKLSRSPSPRRHKKEKKKDK 382
Query: 228 HKKHSKKKKKKAASSSPDS 246
K+ S+ +++++ S S
Sbjct: 383 DKERSRDERERSTSKKKKS 401
Score = 53.9 bits (128), Expect = 1e-07
Identities = 43/185 (23%), Positives = 80/185 (43%), Gaps = 5/185 (2%)
Query: 50 KKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSS 109
++ + S++ ++ +K E+ +K+ K K S + S + +++ + +SG S
Sbjct: 299 ERGRRSRSTSKTRDKKKEDKEKKRSKTPPKSYSTARRSRSASRERRRRRSRSGTRSPKKP 358
Query: 110 SSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTE 169
S S S S KK+ K++ K K RS E S S+ K S K+K + +E
Sbjct: 359 RSPKRKLSRSPSPRRHKKE-KKKDKDKERSRDERERSTSK----KKKSKDKEKDRERKSE 413
Query: 170 KEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHK 229
+KD+K +++ + E E + IE K K+ S E+ + K
Sbjct: 414 SDKDVKQVTRDYDEEEQGYDSEKEKKEEKKPIETGSPKTKECSVEKGTGDSLRESKVNGD 473
Query: 230 KHSKK 234
H ++
Sbjct: 474 DHHEE 478
Score = 42.7 bits (99), Expect = 3e-04
Identities = 37/141 (26%), Positives = 65/141 (46%), Gaps = 14/141 (9%)
Query: 36 RPRPTWEEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKK 95
R R K+ K+K S++ + K + K+ E+ R++ S+SKK++ K
Sbjct: 347 RSRSGTRSPKKPRSPKRKLSRSPSPRRHKKEKKKDKDKERSRDER---ERSTSKKKKSKD 403
Query: 96 KEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSET----- 150
KEK + + S S D + D ++E+ QG +K+K K E+ +T
Sbjct: 404 KEKDRERK----SESDKDVKQVTRDYDEEE--QGYDSEKEKKEEKKPIETGSPKTKECSV 457
Query: 151 ESDSKDSLKKKKKSKDGTEKE 171
E + DSL++ K + D +E
Sbjct: 458 EKGTGDSLRESKVNGDDHHEE 478
>gi|117553580 adaptor-related protein complex 3, delta 1 subunit
isoform 2 [Homo sapiens]
Length = 1153
Score = 65.9 bits (159), Expect = 3e-11
Identities = 47/181 (25%), Positives = 90/181 (49%), Gaps = 20/181 (11%)
Query: 71 KELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSS------SDSEDE 124
+E +HR+KL E ++++RK+KEKK R+SS + S + + + ++ E
Sbjct: 728 EEERRHRQKL----EKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPE 783
Query: 125 DKKQGKRRKKKKNRSHKSSESSMSETESDS-KDSLKKKKKSKDGTEKEKDIKGLSKKRKM 183
+ K N +++ + + + +DS K ++K + ++ EKD+ + KK K
Sbjct: 784 NALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSK- 842
Query: 184 YSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSS 243
KP E ++ E+ R K+KK +E++K+ + KKK + +K + K KK +
Sbjct: 843 ----KPKKKEK----KHKEKERDKEKKKEKEKKKSPKPKKKKHRKEKEERTKGKKKSKKQ 894
Query: 244 P 244
P
Sbjct: 895 P 895
Score = 36.2 bits (82), Expect = 0.027
Identities = 28/106 (26%), Positives = 51/106 (48%), Gaps = 20/106 (18%)
Query: 34 LNRPRPTWEEVKEQLEKKKKGSKALAE---FEEKMNENWKKELEKHREKLLSGSESSSKK 90
L++P E++ Q + + SK+ + EK ++ KK+ +KH+EK K
Sbjct: 806 LDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEK-------ERDK 858
Query: 91 RQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKK 136
++K+KEKKKS + E E++ +GK++ KK+
Sbjct: 859 EKKKEKEKKKSPK----------PKKKKHRKEKEERTKGKKKSKKQ 894
Score = 34.3 bits (77), Expect = 0.10
Identities = 29/157 (18%), Positives = 61/157 (38%), Gaps = 18/157 (11%)
Query: 60 EFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSS 119
+ ++ + ++ K ++KHR S S KK +K K
Sbjct: 805 DLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKK------------KEKKHK 852
Query: 120 DSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSK 179
+ E + +K+ ++ KKK + K E + K KK+ + E G +
Sbjct: 853 EKERDKEKKKEKEKKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAPE 912
Query: 180 KRKMYSEDKPLSSESLSESEYIE---EVRAKKKKSSE 213
+ ++ E S L+E+ Y++ ++R ++ S+
Sbjct: 913 EEQLPPES---SYSLLAENSYVKMTCDIRGSLQEDSQ 946
Score = 33.9 bits (76), Expect = 0.13
Identities = 30/127 (23%), Positives = 55/127 (43%), Gaps = 13/127 (10%)
Query: 119 SDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKK---------KKSKDGTE 169
SDSE ED++ +++ R K S E E + +K+ K S +
Sbjct: 632 SDSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSSPSPQK 691
Query: 170 KEKDIKGLSKKRKMYSE-DKPLSSESLSESEY---IEEVRAKKKKSSEEREKATEKTKKK 225
+ +D G+ + + PL L S+ +EE R ++K +++ + K K+K
Sbjct: 692 RYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKEKEK 751
Query: 226 KKHKKHS 232
K ++HS
Sbjct: 752 KGKRRHS 758
Score = 30.8 bits (68), Expect = 1.1
Identities = 20/86 (23%), Positives = 41/86 (47%), Gaps = 5/86 (5%)
Query: 39 PTWEEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEK 98
P E+ ++ +KK+K K +EK E KK+ K ++K + +K +R K +K
Sbjct: 835 PMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKKSPKPKKK-----KHRKEKEERTKGKK 889
Query: 99 KKSGRYSSSSSSSSDSSSSSSDSEDE 124
K + S ++ + + + E++
Sbjct: 890 KSKKQPPGSEEAAGEPVQNGAPEEEQ 915
>gi|151301228 formin binding protein 3 [Homo sapiens]
Length = 930
Score = 65.9 bits (159), Expect = 3e-11
Identities = 53/203 (26%), Positives = 91/203 (44%), Gaps = 42/203 (20%)
Query: 41 WEEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKK 100
WE+++E+ K+ FE+ E+ +K + K +L + KK KK
Sbjct: 740 WEDIRERFVKEPA-------FEDITLESERKRIFKDFMHVLE--HECQHHHSKNKKHSKK 790
Query: 101 SGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKK 160
S ++ S S S SDS+D+D K+R++ ++RS S SS +E+E K S K
Sbjct: 791 SKKHHRKRSRSR----SGSDSDDDDSHSKKKRQRSESRS-ASEHSSSAESERSYKKSKKH 845
Query: 161 KKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATE 220
KKKSK ++ + D P S A+++K +E+++ +E
Sbjct: 846 KKKSK---------------KRRHKSDSPESD-------------AEREKDKKEKDRESE 877
Query: 221 KTKKKKKHKKHSKKKKKKAASSS 243
K + +++ + K KKK S
Sbjct: 878 KDRTRQRSESKHKSPKKKTGKDS 900
Score = 64.3 bits (155), Expect = 9e-11
Identities = 55/171 (32%), Positives = 81/171 (47%), Gaps = 17/171 (9%)
Query: 39 PTWEEVKEQLEKKK--KGSKALAEFE----EKMNENWKKELEKH---REKLLSGSESSSK 89
P +E++ + E+K+ K + E E N+ K+ +KH R + SGS+S
Sbjct: 751 PAFEDITLESERKRIFKDFMHVLEHECQHHHSKNKKHSKKSKKHHRKRSRSRSGSDSDDD 810
Query: 90 KRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKS-SESSMS 148
KKK ++ S S S+S+ SSS++SE KK K +KK K R HKS S S +
Sbjct: 811 DSHSKKKRQR------SESRSASE-HSSSAESERSYKKSKKHKKKSKKRRHKSDSPESDA 863
Query: 149 ETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESE 199
E E D K+ ++ +K + E K KK S + S LSE E
Sbjct: 864 EREKDKKEKDRESEKDRTRQRSESKHKSPKKKTGKDSGNWDTSGSELSEGE 914
Score = 39.3 bits (90), Expect = 0.003
Identities = 36/163 (22%), Positives = 68/163 (41%), Gaps = 3/163 (1%)
Query: 85 ESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSE 144
++ +++R+R+K+E +K R S+ S ++ + + + +R K+ + E
Sbjct: 700 KAEAREREREKEEARKMKRKESAFKSMLKQAAPPIELDAVWEDIRERFVKEPAFEDITLE 759
Query: 145 SSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEV 204
S D L+ + + K+ K RK S + S +S ++
Sbjct: 760 SERKRIFKDFMHVLEHECQHHHSKNKKHSKKSKKHHRKR-SRSRSGSDSDDDDSHSKKKR 818
Query: 205 RAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSSPDSP 247
+ + +S+ E + E + KK KKH KKK K DSP
Sbjct: 819 QRSESRSASEHSSSAESERSYKKSKKH--KKKSKKRRHKSDSP 859
Score = 35.8 bits (81), Expect = 0.035
Identities = 30/110 (27%), Positives = 51/110 (46%), Gaps = 13/110 (11%)
Query: 46 EQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYS 105
E + S A +E K ++ KK+ +K R K S S S +R++ KKEK +
Sbjct: 822 ESRSASEHSSSAESERSYKKSKKHKKKSKKRRHK--SDSPESDAEREKDKKEKDR----- 874
Query: 106 SSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSK 155
S D + S+S+ K K++ K + + +S S +SE E + +
Sbjct: 875 ---ESEKDRTRQRSESK---HKSPKKKTGKDSGNWDTSGSELSEGELEKR 918
Score = 33.1 bits (74), Expect = 0.23
Identities = 41/201 (20%), Positives = 85/201 (42%), Gaps = 20/201 (9%)
Query: 39 PTWEEVKEQLEKKK--KGSKALAEFEEKMNENWK-KELEKHREKLLSGSESSSKKRQRKK 95
P + + + EKK+ K E EEK K KE ++ ++ L E + + KK
Sbjct: 399 PRYSALAKLSEKKQAFNAYKVQTEKEEKEEARSKYKEAKESFQRFLENHEKMTSTTRYKK 458
Query: 96 KEKKKSGRYSSSSSSSSDSSSSSSDS----EDEDKKQGKRRKKKKNRSHKSSESSMSETE 151
E+ ++ S D D ++K+Q K+ +K+ + K+ +M+
Sbjct: 459 AEQMFGEMEVWNAISERDRLEIYEDVLFFLSKKEKEQAKQLRKRNWEALKNILDNMANVT 518
Query: 152 SDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKS 211
+ S ++ + T E + + + M ED + E E +RA +K+
Sbjct: 519 YSTTWSEAQQYLMDNPTFAEDE-----ELQNMDKEDALICFE--------EHIRALEKEE 565
Query: 212 SEEREKATEKTKKKKKHKKHS 232
EE++K+ + +++++ + S
Sbjct: 566 EEEKQKSLLRERRRQRKNRES 586
>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
Length = 2039
Score = 65.5 bits (158), Expect = 4e-11
Identities = 58/212 (27%), Positives = 96/212 (45%), Gaps = 19/212 (8%)
Query: 43 EVKEQLEKKKKGSKALAEFEEKMNENWKKE---LEKHREKLLSGSESSSKKRQRKKKEKK 99
E K +LEK K K+ E N+K+E ++K EK + K +R+
Sbjct: 698 EKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTD 757
Query: 100 KSGRYSSSSSSSSDSSSSSS--DSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDS 157
K ++S S+ + S + E + +KQ K K+ K + K S+ + E + +
Sbjct: 758 KDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKT 817
Query: 158 LKKKKKSKDGTEKEKDIKGLSK-------KRKMYSEDKPLSSESLSESEYIEEVRAKKKK 210
+K+KK K + EKD LS+ K K+YS + + E E + A KK
Sbjct: 818 FEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHH---TEKCHKEGEKSKNTAAIKK- 873
Query: 211 SSEEREKATEKTKKKKKHKKHSKKKKKKAASS 242
+++REK+ EK +K H K +K++ A S
Sbjct: 874 -TDDREKSREKMDRK--HDKEKPEKERHLAES 902
Score = 60.1 bits (144), Expect = 2e-09
Identities = 59/229 (25%), Positives = 103/229 (44%), Gaps = 34/229 (14%)
Query: 39 PTWEEVKEQLEKKKKGSKALAEFE----EKMNENWKKELEKHREKLLSGSESSSKKRQRK 94
PT+E L+K K K L + + E+ E KKE+E +EK ++ S+K+ QR
Sbjct: 608 PTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKY--KTKDSAKELQRS 665
Query: 95 KKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKN-RSHKSSESSMSETESD 153
+ ++ + + S ++ + E E K+ K +KN + KS++ E +
Sbjct: 666 VEFDREF--WKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERN 723
Query: 154 SKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESL------------------ 195
K+ K KK + + +E+ IK L ++R+ DK SL
Sbjct: 724 FKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEI 783
Query: 196 ---SESEYIEEVRAKKKKSSEEREKATE----KTKKKKKHKKHSKKKKK 237
+ ++I+E + K +K S+ +EK E KT +K+K KH K +K
Sbjct: 784 DIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEK 832
Score = 55.8 bits (133), Expect = 3e-08
Identities = 41/183 (22%), Positives = 85/183 (46%), Gaps = 5/183 (2%)
Query: 60 EFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSS 119
E + + E KE ++ EK E +K +RK EK+K ++ S S
Sbjct: 782 EIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECV 841
Query: 120 DSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKK---KKSKDGTEKEKDIKG 176
D E K +K ++ + S+++ + ++D ++ ++K K K+ EKE+ +
Sbjct: 842 DKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAE 901
Query: 177 LSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKK 236
+K M ++K + S+SE + +K + +++EK+ +K + KH +++K
Sbjct: 902 SKEKHLMEKKNKQSDNSEYSKSE--KGKNKEKDRELDKKEKSRDKESINITNSKHIQEEK 959
Query: 237 KKA 239
K +
Sbjct: 960 KSS 962
Score = 55.1 bits (131), Expect = 6e-08
Identities = 50/207 (24%), Positives = 91/207 (43%), Gaps = 12/207 (5%)
Query: 42 EEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSS--------KKRQR 93
E+ +E++++K K E E + E+ +K L + + K SE S K R+
Sbjct: 878 EKSREKMDRKHDKEKP--EKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDREL 935
Query: 94 KKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESD 153
KKEK + + ++S S D +K Q ++ K ++ + E D
Sbjct: 936 DKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKD 995
Query: 154 SKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEE--VRAKKKKS 211
KD + K +D + + I L K + + KP SS + ++ E+ V ++
Sbjct: 996 KKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQT 1055
Query: 212 SEEREKATEKTKKKKKHKKHSKKKKKK 238
S ER + + + ++ HKKH +K K+K
Sbjct: 1056 SFERMLSLKDLEIEQWHKKHKEKIKQK 1082
Score = 54.7 bits (130), Expect = 7e-08
Identities = 52/240 (21%), Positives = 97/240 (40%), Gaps = 34/240 (14%)
Query: 42 EEVKEQLEKKKKGS----KALAEFEEKMNENWKKELEKHREKL--LSGSESSSKKRQRKK 95
+ +KE EK +K S K + + E K E KK +H+ + L SE K +++ K
Sbjct: 790 KHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDK 849
Query: 96 ------KEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNR----------S 139
++ K G S ++++ + E D+K K + +K+
Sbjct: 850 LYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLME 909
Query: 140 HKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSS------- 192
K+ +S SE K K+K + D EK +D + ++ + +++ SS
Sbjct: 910 KKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKA 969
Query: 193 -----ESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSSPDSP 247
SL E E ++ K ++++K ++ K++ KHK + S D P
Sbjct: 970 QHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKP 1029
Score = 53.9 bits (128), Expect = 1e-07
Identities = 55/215 (25%), Positives = 94/215 (43%), Gaps = 21/215 (9%)
Query: 43 EVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKK-KEKKKS 101
++ E ++K K+ K + EK ++ +K K E S +K RK KEK +
Sbjct: 836 DLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEK 895
Query: 102 GRYSSSSSSSS--DSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETES--DSKDS 157
R+ + S + + SD+ + K + + K+K K +S E+ + +SK
Sbjct: 896 ERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHI 955
Query: 158 LKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREK 217
++KK S K + K LS K K ++D+PL + E + KK +R K
Sbjct: 956 QEEKKSSIVDGNKAQHEKPLSLKEK--TKDEPLKTPDGKEKD--------KKDKDIDRYK 1005
Query: 218 ATEKTKKK------KKHKKHSKKKKKKAASSSPDS 246
+K K K K K + K K K++ +S D+
Sbjct: 1006 ERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDT 1040
Score = 52.0 bits (123), Expect = 5e-07
Identities = 57/241 (23%), Positives = 102/241 (42%), Gaps = 22/241 (9%)
Query: 23 IQSSGPTIQDYLNRPRPTWEE---VKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREK 79
I+ T + ++++ R EE +K++ EK + K EE+ N K+ E
Sbjct: 707 IKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLG 766
Query: 80 LLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKK-NR 138
+ + ES K+ + +K ++ S + S + + E ++ K+KK
Sbjct: 767 MSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKH 826
Query: 139 SHKSSESSMSETESDSKDSLKKK-------KKSKDGTEKEKDIKGLSK-------KRKM- 183
HKS + + +E K K K K K+G EK K+ + K + KM
Sbjct: 827 EHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEG-EKSKNTAAIKKTDDREKSREKMD 885
Query: 184 --YSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAAS 241
+ ++KP L+ES+ + K K+S +EK K K+K ++ KK+K +
Sbjct: 886 RKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKE 945
Query: 242 S 242
S
Sbjct: 946 S 946
Score = 46.2 bits (108), Expect = 3e-05
Identities = 52/219 (23%), Positives = 96/219 (43%), Gaps = 22/219 (10%)
Query: 45 KEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSG-- 102
K +EKK K S + + +N +K+ E +++ ES + + +E+KKS
Sbjct: 905 KHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIV 964
Query: 103 --------RYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSE--SSMSETES 152
+ S + D + D +++DKK + K+ HK +S+ + +S
Sbjct: 965 DGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKS 1024
Query: 153 DS-KDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKS 211
++ K K SKD KEK + ++ S ++ LS + L ++ ++ + K K+
Sbjct: 1025 EADKPKPKSSPASKDTRPKEKRL--VNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQK 1082
Query: 212 SEEREKATE------KTKKKKKHKK-HSKKKKKKAASSS 243
+ER + K K+K KH SK K+ + SS
Sbjct: 1083 EKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSS 1121
Score = 44.3 bits (103), Expect = 1e-04
Identities = 46/177 (25%), Positives = 76/177 (42%), Gaps = 22/177 (12%)
Query: 82 SGSESSSKKRQRKKKEKK---KSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRK--KKK 136
S S S K +++ K +K + G S++ D S + +S+ KK K K KK
Sbjct: 571 SSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKH 630
Query: 137 NRSHKSSESSMSETESD-------SKDSLKKKKKS--------KDGTEKEKDIKGLSKKR 181
HK E + E + +KDS K+ ++S K+ K + + L
Sbjct: 631 KLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLN- 689
Query: 182 KMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKK 238
M E L +S E ++ K+K S+ER E+ K KK+ +K +++K K
Sbjct: 690 -MEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIK 745
Score = 34.3 bits (77), Expect = 0.10
Identities = 51/230 (22%), Positives = 94/230 (40%), Gaps = 40/230 (17%)
Query: 42 EEVKEQLEKKKKGSKALAEFEEKMN-ENWKKELEKHREKLLSGSESSSKKRQRKKKEKKK 100
+E +++ E + + + A+ E+ +++K + +K L S +ESS ++ + KK
Sbjct: 360 KEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTS 419
Query: 101 SGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKD---- 156
+S+S + S E K++GK ++K KN+ +K+ E+ + E + K+
Sbjct: 420 CSVIPETSNSDMQTKKEYVVS-GEHKQKGKVKRKLKNQ-NKNKENQELKQEKEGKENTRI 477
Query: 157 -------------------SLKKKKKSKDGT----------EKEKDIKGLSKKR----KM 183
+ +K KD T + K GLS+K+ K
Sbjct: 478 TNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQ 537
Query: 184 YSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSK 233
LS S S + VR +S E ++ K+ K K+ KH K
Sbjct: 538 EHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQK 587
Score = 32.7 bits (73), Expect = 0.30
Identities = 32/154 (20%), Positives = 62/154 (40%), Gaps = 18/154 (11%)
Query: 82 SGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHK 141
S S+S+ ++ +K K K YS + S S++ +K +RK S
Sbjct: 15 SDSDSNMVEKPYGRKSKDKIASYSKTPKIER-----SDVSKEMKEKSSMKRKLPFTISPS 69
Query: 142 SSESSMSETESDSKDSLKKKKKSKDGTEKEKDI-----------KGLSKKRKMYSEDKPL 190
+E S+TE + + KKK K + G +K + K ++ +M + D
Sbjct: 70 RNEERDSDTEKEGPE--KKKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQMTARDNSP 127
Query: 191 SSESLSESEYIEEVRAKKKKSSEEREKATEKTKK 224
S S+ + SS +++K ++ ++
Sbjct: 128 DSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNER 161
Score = 30.4 bits (67), Expect = 1.5
Identities = 38/188 (20%), Positives = 74/188 (39%), Gaps = 12/188 (6%)
Query: 71 KELEKHREKLLSGS----ESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSD-----S 121
KE +KH++K+ S +S + K + K K R + D +S +
Sbjct: 1005 KERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLK 1064
Query: 122 EDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKR 181
+ E ++ K+ K+K + K + + E KD K K + KE S+
Sbjct: 1065 DLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVT 1124
Query: 182 KMYSEDKPLSSESLSESEYIEEVRAKK-KKSSEEREKATEKTKKKKKHKK--HSKKKKKK 238
Y+++K + S+ ++ KSS + + ++ + + K S+
Sbjct: 1125 DAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLSSRSVSMI 1184
Query: 239 AASSSPDS 246
+ +SS DS
Sbjct: 1185 SVASSEDS 1192
Score = 29.6 bits (65), Expect = 2.5
Identities = 27/93 (29%), Positives = 40/93 (43%), Gaps = 10/93 (10%)
Query: 158 LKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKK------- 210
++ + D EK G K K+ S K E S+ ++E + K+K
Sbjct: 10 IQSENSDSDSNMVEKPY-GRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKRKLPFTISP 68
Query: 211 -SSEEREKATEKT-KKKKKHKKHSKKKKKKAAS 241
+EER+ TEK +KKK KK + KK S
Sbjct: 69 SRNEERDSDTEKEGPEKKKTKKEAGNKKSTPVS 101
>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
Length = 2062
Score = 65.5 bits (158), Expect = 4e-11
Identities = 58/212 (27%), Positives = 96/212 (45%), Gaps = 19/212 (8%)
Query: 43 EVKEQLEKKKKGSKALAEFEEKMNENWKKE---LEKHREKLLSGSESSSKKRQRKKKEKK 99
E K +LEK K K+ E N+K+E ++K EK + K +R+
Sbjct: 721 EKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTD 780
Query: 100 KSGRYSSSSSSSSDSSSSSS--DSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDS 157
K ++S S+ + S + E + +KQ K K+ K + K S+ + E + +
Sbjct: 781 KDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKT 840
Query: 158 LKKKKKSKDGTEKEKDIKGLSK-------KRKMYSEDKPLSSESLSESEYIEEVRAKKKK 210
+K+KK K + EKD LS+ K K+YS + + E E + A KK
Sbjct: 841 FEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHH---TEKCHKEGEKSKNTAAIKK- 896
Query: 211 SSEEREKATEKTKKKKKHKKHSKKKKKKAASS 242
+++REK+ EK +K H K +K++ A S
Sbjct: 897 -TDDREKSREKMDRK--HDKEKPEKERHLAES 925
Score = 60.1 bits (144), Expect = 2e-09
Identities = 59/229 (25%), Positives = 103/229 (44%), Gaps = 34/229 (14%)
Query: 39 PTWEEVKEQLEKKKKGSKALAEFE----EKMNENWKKELEKHREKLLSGSESSSKKRQRK 94
PT+E L+K K K L + + E+ E KKE+E +EK ++ S+K+ QR
Sbjct: 631 PTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKY--KTKDSAKELQRS 688
Query: 95 KKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKN-RSHKSSESSMSETESD 153
+ ++ + + S ++ + E E K+ K +KN + KS++ E +
Sbjct: 689 VEFDREF--WKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERN 746
Query: 154 SKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESL------------------ 195
K+ K KK + + +E+ IK L ++R+ DK SL
Sbjct: 747 FKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEI 806
Query: 196 ---SESEYIEEVRAKKKKSSEEREKATE----KTKKKKKHKKHSKKKKK 237
+ ++I+E + K +K S+ +EK E KT +K+K KH K +K
Sbjct: 807 DIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEK 855
Score = 55.8 bits (133), Expect = 3e-08
Identities = 41/183 (22%), Positives = 85/183 (46%), Gaps = 5/183 (2%)
Query: 60 EFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSS 119
E + + E KE ++ EK E +K +RK EK+K ++ S S
Sbjct: 805 EIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECV 864
Query: 120 DSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKK---KKSKDGTEKEKDIKG 176
D E K +K ++ + S+++ + ++D ++ ++K K K+ EKE+ +
Sbjct: 865 DKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAE 924
Query: 177 LSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKK 236
+K M ++K + S+SE + +K + +++EK+ +K + KH +++K
Sbjct: 925 SKEKHLMEKKNKQSDNSEYSKSE--KGKNKEKDRELDKKEKSRDKESINITNSKHIQEEK 982
Query: 237 KKA 239
K +
Sbjct: 983 KSS 985
Score = 55.1 bits (131), Expect = 6e-08
Identities = 50/207 (24%), Positives = 91/207 (43%), Gaps = 12/207 (5%)
Query: 42 EEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSS--------KKRQR 93
E+ +E++++K K E E + E+ +K L + + K SE S K R+
Sbjct: 901 EKSREKMDRKHDKEKP--EKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDREL 958
Query: 94 KKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESD 153
KKEK + + ++S S D +K Q ++ K ++ + E D
Sbjct: 959 DKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKD 1018
Query: 154 SKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEE--VRAKKKKS 211
KD + K +D + + I L K + + KP SS + ++ E+ V ++
Sbjct: 1019 KKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQT 1078
Query: 212 SEEREKATEKTKKKKKHKKHSKKKKKK 238
S ER + + + ++ HKKH +K K+K
Sbjct: 1079 SFERMLSLKDLEIEQWHKKHKEKIKQK 1105
Score = 54.7 bits (130), Expect = 7e-08
Identities = 52/240 (21%), Positives = 97/240 (40%), Gaps = 34/240 (14%)
Query: 42 EEVKEQLEKKKKGS----KALAEFEEKMNENWKKELEKHREKL--LSGSESSSKKRQRKK 95
+ +KE EK +K S K + + E K E KK +H+ + L SE K +++ K
Sbjct: 813 KHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDK 872
Query: 96 ------KEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNR----------S 139
++ K G S ++++ + E D+K K + +K+
Sbjct: 873 LYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLME 932
Query: 140 HKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSS------- 192
K+ +S SE K K+K + D EK +D + ++ + +++ SS
Sbjct: 933 KKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKA 992
Query: 193 -----ESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSSPDSP 247
SL E E ++ K ++++K ++ K++ KHK + S D P
Sbjct: 993 QHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKP 1052
Score = 53.9 bits (128), Expect = 1e-07
Identities = 55/215 (25%), Positives = 94/215 (43%), Gaps = 21/215 (9%)
Query: 43 EVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKK-KEKKKS 101
++ E ++K K+ K + EK ++ +K K E S +K RK KEK +
Sbjct: 859 DLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEK 918
Query: 102 GRYSSSSSSSS--DSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETES--DSKDS 157
R+ + S + + SD+ + K + + K+K K +S E+ + +SK
Sbjct: 919 ERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHI 978
Query: 158 LKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREK 217
++KK S K + K LS K K ++D+PL + E + KK +R K
Sbjct: 979 QEEKKSSIVDGNKAQHEKPLSLKEK--TKDEPLKTPDGKEKD--------KKDKDIDRYK 1028
Query: 218 ATEKTKKK------KKHKKHSKKKKKKAASSSPDS 246
+K K K K K + K K K++ +S D+
Sbjct: 1029 ERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDT 1063
Score = 52.0 bits (123), Expect = 5e-07
Identities = 57/241 (23%), Positives = 102/241 (42%), Gaps = 22/241 (9%)
Query: 23 IQSSGPTIQDYLNRPRPTWEE---VKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREK 79
I+ T + ++++ R EE +K++ EK + K EE+ N K+ E
Sbjct: 730 IKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLG 789
Query: 80 LLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKK-NR 138
+ + ES K+ + +K ++ S + S + + E ++ K+KK
Sbjct: 790 MSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKH 849
Query: 139 SHKSSESSMSETESDSKDSLKKK-------KKSKDGTEKEKDIKGLSK-------KRKM- 183
HKS + + +E K K K K K+G EK K+ + K + KM
Sbjct: 850 EHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEG-EKSKNTAAIKKTDDREKSREKMD 908
Query: 184 --YSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAAS 241
+ ++KP L+ES+ + K K+S +EK K K+K ++ KK+K +
Sbjct: 909 RKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKE 968
Query: 242 S 242
S
Sbjct: 969 S 969
Score = 46.2 bits (108), Expect = 3e-05
Identities = 52/219 (23%), Positives = 96/219 (43%), Gaps = 22/219 (10%)
Query: 45 KEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSG-- 102
K +EKK K S + + +N +K+ E +++ ES + + +E+KKS
Sbjct: 928 KHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIV 987
Query: 103 --------RYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSE--SSMSETES 152
+ S + D + D +++DKK + K+ HK +S+ + +S
Sbjct: 988 DGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKS 1047
Query: 153 DS-KDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKS 211
++ K K SKD KEK + ++ S ++ LS + L ++ ++ + K K+
Sbjct: 1048 EADKPKPKSSPASKDTRPKEKRL--VNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQK 1105
Query: 212 SEEREKATE------KTKKKKKHKK-HSKKKKKKAASSS 243
+ER + K K+K KH SK K+ + SS
Sbjct: 1106 EKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSS 1144
Score = 44.3 bits (103), Expect = 1e-04
Identities = 46/177 (25%), Positives = 76/177 (42%), Gaps = 22/177 (12%)
Query: 82 SGSESSSKKRQRKKKEKK---KSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRK--KKK 136
S S S K +++ K +K + G S++ D S + +S+ KK K K KK
Sbjct: 594 SSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKH 653
Query: 137 NRSHKSSESSMSETESD-------SKDSLKKKKKS--------KDGTEKEKDIKGLSKKR 181
HK E + E + +KDS K+ ++S K+ K + + L
Sbjct: 654 KLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLN- 712
Query: 182 KMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKK 238
M E L +S E ++ K+K S+ER E+ K KK+ +K +++K K
Sbjct: 713 -MEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIK 768
Score = 34.3 bits (77), Expect = 0.10
Identities = 51/230 (22%), Positives = 94/230 (40%), Gaps = 40/230 (17%)
Query: 42 EEVKEQLEKKKKGSKALAEFEEKMN-ENWKKELEKHREKLLSGSESSSKKRQRKKKEKKK 100
+E +++ E + + + A+ E+ +++K + +K L S +ESS ++ + KK
Sbjct: 383 KEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTS 442
Query: 101 SGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKD---- 156
+S+S + S E K++GK ++K KN+ +K+ E+ + E + K+
Sbjct: 443 CSVIPETSNSDMQTKKEYVVS-GEHKQKGKVKRKLKNQ-NKNKENQELKQEKEGKENTRI 500
Query: 157 -------------------SLKKKKKSKDGT----------EKEKDIKGLSKKR----KM 183
+ +K KD T + K GLS+K+ K
Sbjct: 501 TNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQ 560
Query: 184 YSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSK 233
LS S S + VR +S E ++ K+ K K+ KH K
Sbjct: 561 EHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQK 610
Score = 30.4 bits (67), Expect = 1.5
Identities = 37/170 (21%), Positives = 64/170 (37%), Gaps = 20/170 (11%)
Query: 82 SGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHK 141
S S+S+ ++ +K K K YS + S S++ +K +RK S
Sbjct: 15 SDSDSNMVEKPYGRKSKDKIASYSKTPKIER-----SDVSKEMKEKSSMKRKLPFTISPS 69
Query: 142 SSESSMSETESDSKD----------SLKKKKKSKDGTEKEKDIKGLSKKRKMYSE---DK 188
+E S+T+SD S + K+G EK+K K K+
Sbjct: 70 RNEERDSDTDSDPGHTSENWGERLISSYRTYSEKEGPEKKKTKKEAGNKKSTPVSILFGY 129
Query: 189 PLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKK 238
PLS + + ++ A+ ++ T +KK S ++K K
Sbjct: 130 PLSER--KQMALLMQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDK 177
Score = 30.4 bits (67), Expect = 1.5
Identities = 38/188 (20%), Positives = 74/188 (39%), Gaps = 12/188 (6%)
Query: 71 KELEKHREKLLSGS----ESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSD-----S 121
KE +KH++K+ S +S + K + K K R + D +S +
Sbjct: 1028 KERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLK 1087
Query: 122 EDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKR 181
+ E ++ K+ K+K + K + + E KD K K + KE S+
Sbjct: 1088 DLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVT 1147
Query: 182 KMYSEDKPLSSESLSESEYIEEVRAKK-KKSSEEREKATEKTKKKKKHKK--HSKKKKKK 238
Y+++K + S+ ++ KSS + + ++ + + K S+
Sbjct: 1148 DAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSENEKPGLSSRSVSMI 1207
Query: 239 AASSSPDS 246
+ +SS DS
Sbjct: 1208 SVASSEDS 1215
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 65.1 bits (157), Expect = 5e-11
Identities = 56/230 (24%), Positives = 100/230 (43%), Gaps = 29/230 (12%)
Query: 36 RPRPTWEEVKEQLEKKKKGSKA--LAEFEEKMNENWKKELEKHREKLLSGSESSS----- 88
R T +E K +++K +K + EEKM E K KH E +L E
Sbjct: 2129 RSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEE 2188
Query: 89 -----KKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSS 143
K+R RK+KE K+ + SS D S +E + +K+++ S +
Sbjct: 2189 VIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEE 2248
Query: 144 ESSMSETESDS---KDSLKKKKKSKDGTE--------------KEKDIKGLSKKRKMYSE 186
E E E + ++ +++K+ ++G E KEK + + +K +++ E
Sbjct: 2249 EEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEE 2308
Query: 187 DKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKK 236
+ + SE +ES EE + EE ++ E KK+K+ K +++K
Sbjct: 2309 KEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRK 2358
Score = 50.4 bits (119), Expect = 1e-06
Identities = 55/231 (23%), Positives = 95/231 (41%), Gaps = 45/231 (19%)
Query: 53 KGSKALAEFEEKMNENWK--KELEKHREKLLSGSESSSK-KRQRKKKEKKKSGRYSSSSS 109
K ++L++ K+N+ K ++L + KL +K KR KE++ S S
Sbjct: 2061 KKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDI 2120
Query: 110 SSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKK-----KS 164
D S S+ ++KK ++++K N+ + TE +SK + K + +
Sbjct: 2121 KEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEE 2180
Query: 165 KDGTEKEKDIKGLSKKRKMYSE----DKP------------------------------- 189
+ G E+E+ I L ++ + E DKP
Sbjct: 2181 EGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQ 2240
Query: 190 --LSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKK 238
LSSE E E EE ++ + EE K E+ ++K+ K+ +KKKKK
Sbjct: 2241 ESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKK 2291
Score = 47.4 bits (111), Expect = 1e-05
Identities = 39/201 (19%), Positives = 86/201 (42%), Gaps = 38/201 (18%)
Query: 39 PTWEEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEK 98
P+W++ K+ ++ K+ + + E W+K L + EKL E S + + +++K
Sbjct: 1455 PSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDK 1514
Query: 99 KKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSL 158
K K + K+ + S S + D ++
Sbjct: 1515 KL-----------------------------KWEEWKQVWENMLSSKSKEQQYKDEEEVT 1545
Query: 159 KKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKA 218
+++ S++G EKE+ + E + + E + + RA+KK++ EER+ A
Sbjct: 1546 LEEEVSREGEEKEQQVT---------EEQRHIQEEHKWARIHRKRARAEKKRAQEERKLA 1596
Query: 219 TEKTKKKKKHKKHSKKKKKKA 239
E+ K ++ ++ +++++K A
Sbjct: 1597 QEEEKLAQEERQLAQEERKLA 1617
Score = 47.0 bits (110), Expect = 2e-05
Identities = 38/171 (22%), Positives = 74/171 (43%), Gaps = 27/171 (15%)
Query: 33 YLNRPRPTWEEVKEQLEKKKKGSKAL--AEFEEKMNENWKKELEKHREKLLSGSESSSKK 90
+L R +E K + K+K S + E EE +E + L++ ++ SE ++
Sbjct: 2192 FLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEER 2251
Query: 91 RQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSS-----ES 145
+ +++E+++ + + E+E+KK+ K+ KKK+ K E
Sbjct: 2252 EEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEE 2311
Query: 146 SMSETESDS--------------------KDSLKKKKKSKDGTEKEKDIKG 176
MSE E++S K+ LKK+K+ K ++ K ++G
Sbjct: 2312 IMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRG 2362
Score = 40.4 bits (93), Expect = 0.001
Identities = 36/189 (19%), Positives = 79/189 (41%), Gaps = 13/189 (6%)
Query: 60 EFEEKMNENWKKELEKHREKL----LSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSS 115
+ E+++NEN HR++ L S S K K + + S
Sbjct: 1029 QVEQRLNENLTLS---HRDEKPAFSLDVSMPSELKSSLKPPTVSEESEVAIKPSKGQRRG 1085
Query: 116 SSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIK 175
+ + +G ++ K+++ S+E + E ES ++ + + +++ ++
Sbjct: 1086 QAGVKKHSQKWLRGLKKTKERDSKQMSTEPGLLEDESGTEAAPIEMEEASVYSQWSSSTS 1145
Query: 176 GLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKK 235
+ + + S++K +S + +I + +K ++R+K K KKKHKK K+
Sbjct: 1146 VIKLSKDVDSQEKDISKD------HIALTLKRLQKIRDKRDKKATAQKLKKKHKKKGKEA 1199
Query: 236 KKKAASSSP 244
K ++P
Sbjct: 1200 KVINEETTP 1208
Score = 40.4 bits (93), Expect = 0.001
Identities = 40/198 (20%), Positives = 94/198 (47%), Gaps = 13/198 (6%)
Query: 50 KKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSS 109
K + + +A+ E K + ++ L + EKL +E ++KR++ K+ +K R +
Sbjct: 1622 KITQDDREMAQAEGKFAQK-EETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLA 1680
Query: 110 SSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTE 169
+ + + ++ +R++ + K + E E D ++ K+++
Sbjct: 1681 KKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELN---- 1736
Query: 170 KEKDIKGLSKKRKMYSEDKPLS--SESLSESEYI-----EEVRAKKKKSSEEREKATEKT 222
+++ K + +K+K+ E++ L+ E LSE E E + +K+K ++ +EK E+
Sbjct: 1737 -QEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEE 1795
Query: 223 KKKKKHKKHSKKKKKKAA 240
++ + ++ +KK K A
Sbjct: 1796 ERLGRKREQLIEKKMKLA 1813
Score = 40.4 bits (93), Expect = 0.001
Identities = 55/234 (23%), Positives = 104/234 (44%), Gaps = 33/234 (14%)
Query: 42 EEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSK------KRQRK- 94
E+ Q +K+ +G +A+ E+ +N K+ L + + +L+ G E+ SK RQRK
Sbjct: 1940 EKAMVQGKKRLRGELDIAKEEKALNLEMKR-LAEEKMRLVEGKETLSKGETPETSRQRKM 1998
Query: 95 -KKEKKKSGRYSSSSSS---SSDSSSSSSDSEDEDKK-----------QGKRRKKKKNRS 139
+ E++ R S D + +SE K QG+R+ K +R
Sbjct: 1999 TQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRK 2058
Query: 140 HKSSESSMSETESDSKDSLKKKKKSKDGTEK--EKDIKGLSKKRKMYSEDKPLSSES--- 194
S+S+ + LK +K K +++IK KR ++ +++ LS E
Sbjct: 2059 LIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKL 2118
Query: 195 -LSESEYIE---EVRAKKKKSSEEREKATEKTKKK-KKHKKHSKKKKKKAASSS 243
+ E ++ E E+ +KK + ++ K K ++ K +K ++++ K A S
Sbjct: 2119 DIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHS 2172
Score = 40.0 bits (92), Expect = 0.002
Identities = 52/215 (24%), Positives = 91/215 (42%), Gaps = 17/215 (7%)
Query: 35 NRPRPTWEEVKEQLEKKKKG--SKALAEFEEKMNENW-----KKELEKHREKLLSGSESS 87
N+ R T + + K K G +K LA+ EEK+ + KKE EK L E S
Sbjct: 1863 NKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDS 1922
Query: 88 SKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSM 147
K+Q K ++K + D E+K K+ + E
Sbjct: 1923 LAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKE 1982
Query: 148 SETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRK-MYSEDKPLSSESLSESEY----IE 202
+ ++ ++ ++ +++K ++ E+E + LS + K + ED+ L+ E ESE +E
Sbjct: 1983 TLSKGETPETSRQRKMTQ--VEQELFERKLSLEEKILLHEDRILAME---ESEIAKGKLE 2037
Query: 203 EVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKK 237
R ++ +R+ A K KK + SK+ K
Sbjct: 2038 FTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAK 2072
Score = 39.7 bits (91), Expect = 0.002
Identities = 47/232 (20%), Positives = 100/232 (43%), Gaps = 38/232 (16%)
Query: 42 EEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKS 101
E + ++ EK + ++ LA+ +K+ + W+K + + G + + K +K ++
Sbjct: 1642 ETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELP 1701
Query: 102 GRYSSSSSSSS-----------DSSSSSSDSEDEDKKQGKRRKKKKNRSHKS-------S 143
R + D S E+ ++++GK ++KK + +
Sbjct: 1702 QREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQRE 1761
Query: 144 ESSMSETESDSKDSLKKKKKSKDGTEKEK---DIKGLSKKRKMYSEDKPL---------- 190
+ S ET+ ++ L ++K K KEK + + L +KR+ E K
Sbjct: 1762 KLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWIN 1821
Query: 191 SSESLSESEYI----EEVRAKKKKSSEEREKATEKTKK---KKKHKKHSKKK 235
S E L++++ I + + +KK ++E+EK ++ + K+ HSKK+
Sbjct: 1822 SMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQ 1873
Score = 39.3 bits (90), Expect = 0.003
Identities = 37/220 (16%), Positives = 101/220 (45%), Gaps = 12/220 (5%)
Query: 29 TIQDYLNRPRPTWEEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSS 88
T+++ ++R E+ + ++ + A K KK ++ R+ + +
Sbjct: 1545 TLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQ 1604
Query: 89 KKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMS 148
++RQ ++E+K + Y + + + + +++ +R +K + K ++
Sbjct: 1605 EERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKK 1664
Query: 149 ETESDSKDSLKKKKKSKDGTEKEKDIKGL---------SKKRKMYSEDKPLSSESLSESE 199
+ K + +++K +K G K ++K + +++ + ++K L+ E L E E
Sbjct: 1665 LAKKWEKVAREEEKLAKKG-GKLAEVKNILAQKVEELPQREQNLDWQEKELAQE-LEELE 1722
Query: 200 Y-IEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKK 238
+ +EE+ K+++ ++E K E+ KK + ++ +++K
Sbjct: 1723 WDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREK 1762
Score = 37.4 bits (85), Expect = 0.012
Identities = 28/110 (25%), Positives = 55/110 (50%), Gaps = 5/110 (4%)
Query: 42 EEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKS 101
EEV+E+ E++K+ + + EK E KK+ +K ++K E K+ ++KE+ S
Sbjct: 2260 EEVREEEEERKEEEEGEEKQVEKEEEE-KKKKKKEKKK----EEVQEKEEVFEEKEEIMS 2314
Query: 102 GRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETE 151
+ S S + S S E+ D+++ +K+K+ + + S+ E
Sbjct: 2315 EEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRE 2364
Score = 36.2 bits (82), Expect = 0.027
Identities = 38/212 (17%), Positives = 95/212 (44%), Gaps = 8/212 (3%)
Query: 42 EEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKR----QRKK-- 95
E++ + EK + + L E++ E K +L + RE+ ++ E +K + Q+K
Sbjct: 1782 EKLAQHKEKMPEEEERLGRKREQLIEK-KMKLAQKRERWINSMEELTKNKMILYQKKNLA 1840
Query: 96 KEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSK 155
+EKK + + ++ + + KKQ + K K +K + + +
Sbjct: 1841 QEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKE 1900
Query: 156 DSLKKKKKSKDGTEKEKDIK-GLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEE 214
+KKK+K + +K ++ L+KK++ +++K + + + + +R + + EE
Sbjct: 1901 TVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEE 1960
Query: 215 REKATEKTKKKKKHKKHSKKKKKKAASSSPDS 246
+ E + ++ + + K+ + +P++
Sbjct: 1961 KALNLEMKRLAEEKMRLVEGKETLSKGETPET 1992
Score = 33.5 bits (75), Expect = 0.18
Identities = 35/197 (17%), Positives = 84/197 (42%), Gaps = 13/197 (6%)
Query: 41 WEEVKE----QLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKK------ 90
WEE K+ L K K + E E + E +E E+ +++ ++
Sbjct: 1518 WEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARI 1577
Query: 91 -RQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSE 149
R+R + EKK++ + + E++K + K + +++
Sbjct: 1578 HRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKF 1637
Query: 150 TESDSKDSLKKKKKSKDGTEKEKDIKGLSKK-RKMYSEDKPLSSESLSESEYIEEVRAKK 208
+ + + + +K S++ + + K L+KK K+ E++ L+ + +E ++ + A+K
Sbjct: 1638 AQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAE-VKNILAQK 1696
Query: 209 KKSSEEREKATEKTKKK 225
+ +RE+ + +K+
Sbjct: 1697 VEELPQREQNLDWQEKE 1713
Score = 32.0 bits (71), Expect = 0.51
Identities = 37/171 (21%), Positives = 68/171 (39%), Gaps = 16/171 (9%)
Query: 39 PTWEEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEK 98
PT E E K KG + +K ++ W + L+K +E+ S+ S + + E
Sbjct: 1066 PTVSEESEVAIKPSKGQRRGQAGVKKHSQKWLRGLKKTKER---DSKQMSTEPGLLEDES 1122
Query: 99 KKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSL 158
+S S SSS S + K ++K ++ H + +L
Sbjct: 1123 GTEAAPIEMEEASVYSQWSSSTSVIKLSKDVDSQEKDISKDHIAL-------------TL 1169
Query: 159 KKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKK 209
K+ +K +D +K+ + L KK K ++ + +E + + V K K
Sbjct: 1170 KRLQKIRDKRDKKATAQKLKKKHKKKGKEAKVINEETTPPVMEQPVTKKVK 1220
Score = 28.1 bits (61), Expect = 7.4
Identities = 40/202 (19%), Positives = 80/202 (39%), Gaps = 15/202 (7%)
Query: 31 QDYLNRPRPTWEEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKK 90
Q+ L P+WE +E KK SK L E + +W ++ +K + E + ++
Sbjct: 1274 QEMLVDRHPSWELFQEICPLLKKESKVLLE-----DLDW--DVVPPEKKPIFIQEGAIRE 1326
Query: 91 RQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSET 150
+ ++ + + D ++ Q +K KK + +M +
Sbjct: 1327 DMIQGVTQEVIRHKEVMPREEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKE 1386
Query: 151 ESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKK 210
S ++ +K K G K + K+RK+ + ++ E SE +EE+ ++K
Sbjct: 1387 ISKKEEKKTFQKSPKQGR------KAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEK 1440
Query: 211 SSEEREKAT--EKTKKKKKHKK 230
++ K E+T + KK
Sbjct: 1441 VVKQEGKLVMIERTPSWQDWKK 1462
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 64.3 bits (155), Expect = 9e-11
Identities = 67/256 (26%), Positives = 112/256 (43%), Gaps = 49/256 (19%)
Query: 36 RPRPTWEEVKEQLEKKKKGSKALAE-FEEKMNENWK------KELEKHREKLLSGSESSS 88
+P EE +KKKKG K + F++ +E + K+ K + ++ SGS+
Sbjct: 82 KPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDD 141
Query: 89 KKRQRKKKEK---KKSGRYSSSSSSSSDSS---------SSSSDSEDE-DKKQGKRRKKK 135
+ KK K +KS + S D+S +SS +S DE D+ R+ +K
Sbjct: 142 DFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQK 201
Query: 136 KNRSHKSSESSMSETESD----------SKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYS 185
KN+ +K + S E D K + KK+++ K E++ ++ L +K ++ +
Sbjct: 202 KNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELET 261
Query: 186 EDKPLSSESLSESEYIEEVRAKK--------KKSSEEREKAT-----------EKTKKKK 226
K S + S+ ++ EE K S E+ E T +K KKKK
Sbjct: 262 GKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKK 321
Query: 227 KHKKHSKKKKKKAASS 242
K +K K+K+KK S
Sbjct: 322 KGEKEEKEKEKKKGPS 337
Score = 62.8 bits (151), Expect = 3e-10
Identities = 52/241 (21%), Positives = 107/241 (44%), Gaps = 36/241 (14%)
Query: 23 IQSSGPTIQDYLNRPRPTWEEVKEQLEK--------KKKGSKALAEFEEKMNENWKKELE 74
+QS ++ N+P P E E + +KK K E +++ E K
Sbjct: 194 LQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKL 253
Query: 75 KHREKLLSGSESSSKKRQRKKKEKKKSGRYS--------SSSSSSSDSSSSSSDSEDEDK 126
K +E+L +G + SK+++ ++K ++++ + +S +++ +++ D + DK
Sbjct: 254 KEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDK 313
Query: 127 KQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSE 186
K+ ++KKK + K E +++ K + K K+ E++K
Sbjct: 314 KKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQK-------------- 359
Query: 187 DKPLSSESLSESEYIEEVRAKKKKSSE-EREKATEKTKKKKKHKKHSKKKKKKAASSSPD 245
E + +EE+ AK+K+ E+EK K +K+K+ K+ KK+ K S +
Sbjct: 360 -----REEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQRE 414
Query: 246 S 246
+
Sbjct: 415 A 415
Score = 55.8 bits (133), Expect = 3e-08
Identities = 50/210 (23%), Positives = 87/210 (41%), Gaps = 28/210 (13%)
Query: 47 QLEKKKKGSKALAEFEEKMNENWKKELE--------KHREKLLSGSESSSK-------KR 91
+L KK KG +K N+ W E K R ++ S ES + ++
Sbjct: 145 KLPKKAKGKA------QKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRK 198
Query: 92 QRKKKEKKKSGRYSSSSSSSSDSSSSSSD--SEDEDKKQGKRRKKKKNRSHKSSESSMSE 149
+KK +K K G S + D+S + +KK+ +R+K+ + ++ E
Sbjct: 199 GQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEE 258
Query: 150 TESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKK 209
E+ KD K+K+ + E+ + K + + P S E E+ K
Sbjct: 259 LETGKKDQSKQKESQRKFEEET-----VKSKVTVDTGVIPASEEKAETPTAAEDDNEGDK 313
Query: 210 KSSEEREKATEKTKKKKKHKKHSKKKKKKA 239
K ++++K EK +K+K+ KK K KA
Sbjct: 314 KKKDKKKKKGEKEEKEKEKKKGPSKATVKA 343
Score = 53.5 bits (127), Expect = 2e-07
Identities = 55/221 (24%), Positives = 98/221 (44%), Gaps = 38/221 (17%)
Query: 45 KEQLEKKKKGSKALAEFEEKMNEN-WKKELE---------KHREKLLSGSESSSKKRQRK 94
KEQ +K KG K + ++ +E+ KELE K + ++ + + + +
Sbjct: 33 KEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFT 92
Query: 95 KKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNR----SHKSSESSMSET 150
K+KKK G+ S +DSE+ + K K +K K + S + ++
Sbjct: 93 SKDKKKKGQ------KGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKL 146
Query: 151 ESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSES-EYIEEVRAKKK 209
+K +K K DG+E+++D K+R + S ES ES E+++ + +KK
Sbjct: 147 PKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINS----SGESGDESDEFLQSRKGQKK 202
Query: 210 ----------KSSEEREKATEKTK---KKKKHKKHSKKKKK 237
+S E + A+ K K +KK KK ++KK+
Sbjct: 203 NQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKR 243
Score = 47.8 bits (112), Expect = 9e-06
Identities = 48/221 (21%), Positives = 101/221 (45%), Gaps = 19/221 (8%)
Query: 23 IQSSGPTI--QDYLNRPRPTWEEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKL 80
+Q+ G + +D L + RP +E+ K + ++ SK ++E EL E +
Sbjct: 426 LQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSE---------SMELCAAVEVM 476
Query: 81 LSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSH 140
G + + E+++ + + D + +SD E E + K + K
Sbjct: 477 EQGVPEKEETPPPVEPEEEED----TEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPE 532
Query: 141 KSSESSMSETESDSKDSLKKKKKSKDGTE-KEKDIKGLSKKRKMYSEDKPLSSESLSESE 199
+ E E E + + ++++ +G+E E+D K +K + DK S E S+SE
Sbjct: 533 EEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSE 592
Query: 200 Y-IEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKA 239
Y ++ R K++++ ++ ++ E K++ +H K+ +K +A
Sbjct: 593 YDSDDDRTKEERAYDKAKRRIE--KRRLEHSKNVNTEKLRA 631
Score = 44.3 bits (103), Expect = 1e-04
Identities = 38/168 (22%), Positives = 76/168 (45%), Gaps = 11/168 (6%)
Query: 39 PTWEEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQ--RKKK 96
PT E + +KKKK K +E+ + KK K K + + + K+ + +K++
Sbjct: 302 PTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKRE 361
Query: 97 EKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKD 156
E+++ R + + + + K++ K RK++ + K S E + ++
Sbjct: 362 EEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEA 421
Query: 157 SLK------KKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSES 198
+LK + SKD K++ I K++K+ + L S+ +SES
Sbjct: 422 TLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKI---PQQLESKEVSES 466
Score = 43.5 bits (101), Expect = 2e-04
Identities = 40/211 (18%), Positives = 88/211 (41%), Gaps = 23/211 (10%)
Query: 45 KEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSS---------------- 88
KE+LE KK E + K E K ++ SE +
Sbjct: 256 KEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKK 315
Query: 89 ---KKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSES 145
KK++ +K+EK+K + S ++ + + ++E+++Q + +++ R +
Sbjct: 316 KDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAK 375
Query: 146 SMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVR 205
E + + +KK+K K+ E+ K L K + + + ++ L +++ +E
Sbjct: 376 RKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVE--- 432
Query: 206 AKKKKSSEEREKATEKTKKKKKHKKHSKKKK 236
K S +++ + KK+KK + + K+
Sbjct: 433 -VPSKDSLPKKRPIYEDKKRKKIPQQLESKE 462
Score = 42.7 bits (99), Expect = 3e-04
Identities = 34/180 (18%), Positives = 73/180 (40%), Gaps = 26/180 (14%)
Query: 90 KRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSE----- 144
K+Q+ K E + ++ + ++ ++ K +GK++K+KK + +
Sbjct: 3 KKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKEL 62
Query: 145 ---------------------SSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKM 183
+ +E E SKD KK +K K + + D + L K
Sbjct: 63 EELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSK 122
Query: 184 YSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSS 243
+ E S S+ ++ KK+ + +K+ +K ++ + +SKK K+++ +S
Sbjct: 123 SKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINS 182
Score = 40.4 bits (93), Expect = 0.001
Identities = 45/222 (20%), Positives = 99/222 (44%), Gaps = 44/222 (19%)
Query: 43 EVKEQLEKKKKGS-----KALAEFEEKMNENWKKELEKHREKLLSGSESSSKKR------ 91
E +E+ ++KKKG KA+ E K+ E +++ + E++ E +K++
Sbjct: 324 EKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLE 383
Query: 92 QRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSM---- 147
Q K++ KK+ + ++ KK+GK K + + +E+++
Sbjct: 384 QEKRERKKQ----------------KEKERKERLKKEGKLLTKSQREARARAEATLKLLQ 427
Query: 148 -SETESDSKDSLKKKKKSKDGTEKEK-----DIKGLSKKRKMYSEDKPLSSESLSESEYI 201
E SKDSL KK+ + +++K + K +S+ ++ + + + + E
Sbjct: 428 AQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETP 487
Query: 202 EEVRAKKKKSSE-------EREKATEKTKKKKKHKKHSKKKK 236
V ++++ +E E + E+T+K + +K H + K+
Sbjct: 488 PPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKE 529
Score = 35.0 bits (79), Expect = 0.060
Identities = 28/118 (23%), Positives = 52/118 (44%), Gaps = 17/118 (14%)
Query: 133 KKKKNRSHKSSESSMS----ETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDK 188
KK+KN+S S++ + E + + K+++ K +K+K+ KK++ + ED
Sbjct: 3 KKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKE-----KKKQDFDEDD 57
Query: 189 PLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSSPDS 246
L +EE+ + + +RE K + + + SK KKKK S
Sbjct: 58 ILKE--------LEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQS 107
Score = 33.5 bits (75), Expect = 0.18
Identities = 53/228 (23%), Positives = 84/228 (36%), Gaps = 38/228 (16%)
Query: 42 EEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLS-----GSESSSKKRQRKKK 96
+E +E+ ++K+K K + E K+ ++E E L G E SK KK+
Sbjct: 384 QEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKR 443
Query: 97 ---EKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSE--------- 144
E KK + S S S + E +QG K++ + E
Sbjct: 444 PIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGL 503
Query: 145 ------SSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSES 198
+S ETE + + + K E+E E++ + SE
Sbjct: 504 DDWEAMASDEETEKVEGNKVHIEVKENPEEEEE--------------EEEEEEEDEESEE 549
Query: 199 EYIEEVRAKKKKSSEEREKAT-EKTKKKKKHKKHSKKKKKKAASSSPD 245
E EE ++ + EE EK + EK K KK SK+ + S D
Sbjct: 550 EEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDD 597
>gi|56090620 NFKB activating protein-like [Homo sapiens]
Length = 402
Score = 64.3 bits (155), Expect = 9e-11
Identities = 33/84 (39%), Positives = 53/84 (63%), Gaps = 5/84 (5%)
Query: 74 EKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRK 133
E+HR+K S S +KK+++ K K+K +YS S S+S ++S SD +DKK+ K +K
Sbjct: 173 EEHRKK--KTSRSRNKKKRKNKSSKRKHRKYSDSDSNSESDTNSDSD---DDKKRVKAKK 227
Query: 134 KKKNRSHKSSESSMSETESDSKDS 157
KKK + HK+ + +T+ +S DS
Sbjct: 228 KKKKKKHKTKKKKNKKTKKESSDS 251
Score = 58.2 bits (139), Expect = 7e-09
Identities = 49/162 (30%), Positives = 73/162 (45%), Gaps = 21/162 (12%)
Query: 85 ESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSE 144
E RQR+ KE+++ G + DS++ + + +H+ S
Sbjct: 112 EKEESHRQRRLKERERIGELGAPEVWGPSPKFPQLDSDEHTPVEDEEEV-----THQKSS 166
Query: 145 SSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEV 204
SS S +E +KKK S+ +K++ K +K + YS+ S+S SES+ +
Sbjct: 167 SSDSNSEEH-----RKKKTSRSRNKKKRKNKSSKRKHRKYSD-----SDSNSESDTNSDS 216
Query: 205 RAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSSPDS 246
KK R KA +K KKKKKHK KK KK SS S
Sbjct: 217 DDDKK-----RVKAKKK-KKKKKHKTKKKKNKKTKKESSDSS 252
Score = 56.2 bits (134), Expect = 3e-08
Identities = 52/168 (30%), Positives = 81/168 (48%), Gaps = 29/168 (17%)
Query: 62 EEKMNENWKKELEKHREKLLSGSES-------------------SSKKRQRKKKEKKKSG 102
E + E+++KE E HR++ L E S + + E++ +
Sbjct: 104 ERQSAEDYEKE-ESHRQRRLKERERIGELGAPEVWGPSPKFPQLDSDEHTPVEDEEEVTH 162
Query: 103 RYSSSSSSSSDSSSSSSDSEDEDKKQGKRRK-KKKNRSHKSSES-SMSETESDSKDS--- 157
+ SSSS S+S+ S +KK+ K + K+K+R + S+S S S+T SDS D
Sbjct: 163 QKSSSSDSNSEEHRKKKTSRSRNKKKRKNKSSKRKHRKYSDSDSNSESDTNSDSDDDKKR 222
Query: 158 LKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPL--SSESLSESEYIEE 203
+K KKK K +K K K +KK K S D S E LSE+ ++E+
Sbjct: 223 VKAKKKKK--KKKHKTKKKKNKKTKKESSDSSCKDSEEDLSEATWMEQ 268
Score = 36.6 bits (83), Expect = 0.021
Identities = 28/111 (25%), Positives = 53/111 (47%), Gaps = 5/111 (4%)
Query: 140 HKSSESSMSETESDSKDSLKK---KKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLS 196
H +E S + + ++S ++ K++ + G ++ G S K D+ E
Sbjct: 99 HCYAEERQSAEDYEKEESHRQRRLKERERIGELGAPEVWGPSPKFPQLDSDEHTPVEDEE 158
Query: 197 ESEYIEEVRAKKKKSSEEREKATEKTKKKKKHK-KHSKKKKKKAASSSPDS 246
E + ++ + S E R+K T +++ KKK K K SK+K +K + S +S
Sbjct: 159 EVTH-QKSSSSDSNSEEHRKKKTSRSRNKKKRKNKSSKRKHRKYSDSDSNS 208
Score = 34.7 bits (78), Expect = 0.079
Identities = 43/201 (21%), Positives = 76/201 (37%), Gaps = 14/201 (6%)
Query: 50 KKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSS---------KKRQRKKKEKKK 100
+KKK S++ K K KHR+ S S S S KKR + KK+KKK
Sbjct: 176 RKKKTSRS----RNKKKRKNKSSKRKHRKYSDSDSNSESDTNSDSDDDKKRVKAKKKKKK 231
Query: 101 SGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKK 160
++ + + + SSDS +D ++ + + + + E+ + +
Sbjct: 232 K-KHKTKKKKNKKTKKESSDSSCKDSEEDLSEATWMEQPNVADTMDLIGPEAPIIHTSQD 290
Query: 161 KKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATE 220
+K K G + + P E SE I S R + E
Sbjct: 291 EKPLKYGHALLPGEGAAMAEYVKAGKRIPRRGEIGLTSEEIGSFECSGYVMSGSRHRRME 350
Query: 221 KTKKKKKHKKHSKKKKKKAAS 241
+ +K+++ +S +K+ AS
Sbjct: 351 AVRLRKENQIYSADEKRALAS 371
Score = 30.8 bits (68), Expect = 1.1
Identities = 16/77 (20%), Positives = 38/77 (49%), Gaps = 1/77 (1%)
Query: 45 KEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRY 104
K + + K+ + ++ + + + + ++++ + + KK + KKK+ KK+ +
Sbjct: 188 KRKNKSSKRKHRKYSDSDSNSESDTNSDSDDDKKRVKAKKKKKKKKHKTKKKKNKKT-KK 246
Query: 105 SSSSSSSSDSSSSSSDS 121
SS SS DS S++
Sbjct: 247 ESSDSSCKDSEEDLSEA 263
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 63.9 bits (154), Expect = 1e-10
Identities = 41/198 (20%), Positives = 97/198 (48%), Gaps = 8/198 (4%)
Query: 42 EEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKK-KEKKK 100
E + + E++++ + E E + +KE E+ RE+ +K+R R + +E+ +
Sbjct: 308 ERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDR 367
Query: 101 SGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKK 160
SS + D S S S D ++++ + R++++ R + E E + ++ ++
Sbjct: 368 DRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERERERE-RERERE 426
Query: 161 KKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATE 220
K K +D E E+D ++RK+ ++ L + + E ++ +++K + E EK E
Sbjct: 427 KDKKRDREEDEED---AYERRKL---ERKLREKEAAYQERLKNWEIRERKKTREYEKEAE 480
Query: 221 KTKKKKKHKKHSKKKKKK 238
+ +++++ K+ K+
Sbjct: 481 REEERRREMAKEAKRLKE 498
Score = 62.8 bits (151), Expect = 3e-10
Identities = 41/212 (19%), Positives = 103/212 (48%), Gaps = 4/212 (1%)
Query: 31 QDYLNRPRPTWEEVKEQLEKKK-KGSKALAEFEEKMNENWK-KELEKHREKLLSGSESSS 88
+D ++R + + ++LE++K K K E E++ E + +E E+ R + E
Sbjct: 274 RDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERERERER 333
Query: 89 KKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMS 148
++ + K++E+++ + D D D+++ R K ++RS + S
Sbjct: 334 EREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRER 393
Query: 149 ETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKK 208
E E + + +++++ + E+E++ + ++ K D+ E E +E +K
Sbjct: 394 EREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREK 453
Query: 209 KKSSEEREKATE--KTKKKKKHKKHSKKKKKK 238
+ + +ER K E + KK ++++K +++++++
Sbjct: 454 EAAYQERLKNWEIRERKKTREYEKEAEREEER 485
Score = 54.7 bits (130), Expect = 7e-08
Identities = 36/177 (20%), Positives = 84/177 (47%), Gaps = 6/177 (3%)
Query: 72 ELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKR 131
E+E+ + L+S E S + KK E++K + + + E E +++ +
Sbjct: 268 EMEEDKRDLIS-REISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERE 326
Query: 132 RKKKKNRSHKSSESSMSETESD-SKDSLKKKKKSKDGT-EKEKDIKGLSKKRKMYSEDKP 189
R++++ R + + E E D +D K++ + +D ++++D + S + K S +
Sbjct: 327 REREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSRE 386
Query: 190 LSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSSPDS 246
S + E E R ++++ ERE+ E+ +++++ ++ K KK+ D+
Sbjct: 387 KSRDRERERE---REREREREREREREREREREREREREREREKDKKRDREEDEEDA 440
Score = 51.2 bits (121), Expect = 8e-07
Identities = 39/179 (21%), Positives = 79/179 (44%), Gaps = 12/179 (6%)
Query: 60 EFEEKMNENWKKELEKHRE---KLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSS 116
E EE + +E+ K R+ KL K+RQ +KE+++ R +
Sbjct: 268 EMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERER-------ERERER 320
Query: 117 SSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKG 176
+ E E +++ +R K+K+ + + T+ +D +++ + +D K
Sbjct: 321 ERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKD 380
Query: 177 LSKKRKMYSEDKPLSSESLSESEYIEE-VRAKKKKSSEEREKATEKTKKKKKHKKHSKK 234
S+ R+ S D+ E E E E R ++++ ERE+ E+ K KK+ ++ ++
Sbjct: 381 RSRSREK-SRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEE 438
Score = 48.5 bits (114), Expect = 5e-06
Identities = 39/191 (20%), Positives = 85/191 (44%), Gaps = 24/191 (12%)
Query: 72 ELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKR 131
+L+ +KLL ++ +K + + K KKK+ ++ + ++ + D E + + Q +
Sbjct: 149 DLQIGEKKLLVKVDAKTKAQLDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMIK 208
Query: 132 RKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKD----------------------GTE 169
+ SSE + ESDS KKK+K +D E
Sbjct: 209 GAIEVLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIE 268
Query: 170 KEKDIKGLSKKR--KMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKK 227
E+D + L + K K L E + + +E+ ++++ ERE+ E+ +++++
Sbjct: 269 MEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERE 328
Query: 228 HKKHSKKKKKK 238
++ +++K+K
Sbjct: 329 REREREREKEK 339
Score = 47.0 bits (110), Expect = 2e-05
Identities = 27/180 (15%), Positives = 78/180 (43%)
Query: 66 NENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDED 125
N++ + EK R++ ++R+R+++ +++ R D E+++
Sbjct: 378 NKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDE 437
Query: 126 KKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYS 185
+ +RRK ++ K + + ++ K ++ K+ +E+ + ++K+ K
Sbjct: 438 EDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLK 497
Query: 186 EDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSSPD 245
E + + +Y +K+ E+E ++ +K++ ++ + +++ A PD
Sbjct: 498 EFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPD 557
Score = 42.0 bits (97), Expect = 5e-04
Identities = 45/224 (20%), Positives = 99/224 (44%), Gaps = 29/224 (12%)
Query: 43 EVKEQLEK---KKKGSKALAEFEEKMNENWKK--ELEKHREKLLSGS------------- 84
+ K QL++ KKK S A E N++ + E K R++++ G+
Sbjct: 164 KTKAQLDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELN 223
Query: 85 ----ESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSE----DEDKKQGKRRKKKK 136
ES S R++KK++K+ R + + D +EDK+ R+ K
Sbjct: 224 APSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISK 283
Query: 137 NR-SHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESL 195
R +HK E + E + ++ K++++ + E+E++ + ++R+ E +
Sbjct: 284 FRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERER 343
Query: 196 SESEYIEEVRAKKKKSSEEREKATEKTKKKK--KHKKHSKKKKK 237
+ R K++ +RE+ ++ +++ ++K S+ ++K
Sbjct: 344 ERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREK 387
Score = 39.7 bits (91), Expect = 0.002
Identities = 34/237 (14%), Positives = 94/237 (39%), Gaps = 37/237 (15%)
Query: 45 KEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRY 104
K++ ++K E E + ++E E+ RE+ ++R++ KK ++
Sbjct: 379 KDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEE 438
Query: 105 SSSSSSSSDSSSSSSDSEDEDK-KQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKK 163
+ + ++ +++ K + R++KK R ++ E + K+ K+
Sbjct: 439 DAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKE 498
Query: 164 SKDGTEKEKD----IKGLSKKRKMYSEDKPLSSESLS---ESEYIEEVRA---------- 206
+ + ++D +G + ++++ +K + ++ E E +EE+R
Sbjct: 499 FLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDP 558
Query: 207 -------------------KKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSSP 244
K++ SEE E+ ++ ++K++ +++ ++ P
Sbjct: 559 DAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQKPCLKP 615
Score = 35.8 bits (81), Expect = 0.035
Identities = 44/213 (20%), Positives = 85/213 (39%), Gaps = 40/213 (18%)
Query: 46 EQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYS 105
EQ ++++ + E E + E K+E E+ RE+ + E +K K + S S
Sbjct: 566 EQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQKPCLKPTLRPISSAPS 625
Query: 106 SSSSSSSDSSSSSSD----------SEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSK 155
SS+S + + ++ D D++Q + + K S K S+
Sbjct: 626 VSSASGNATPNTPGDESPCGIIIPHENSPDQQQPEEHRPKIGLSLKLGASN----SPGQP 681
Query: 156 DSLKKKKKSKDGT---EKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSS 212
+S+K+KK D +++D + +KRK+ D
Sbjct: 682 NSVKRKKLPVDSVFNKFEDEDSDDVPRKRKLVPLD-----------------------YG 718
Query: 213 EEREKATEKTKKKKKHKKHSKKKKKKAASSSPD 245
E+ + AT+ T ++ +KH K +K ++ P+
Sbjct: 719 EDDKNATKGTVNTEEKRKHIKSLIEKIPTAKPE 751
>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
[Homo sapiens]
Length = 1412
Score = 63.5 bits (153), Expect = 2e-10
Identities = 49/182 (26%), Positives = 84/182 (46%), Gaps = 21/182 (11%)
Query: 46 EQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYS 105
E LE+++K K + +E + W+ R++ LSG + +++ + KKK+K +G
Sbjct: 1245 ELLEQERK--KVVDTTKESSRKGWES-----RKRKLSGDQPAARTPRSKKKKKLGAGEGG 1297
Query: 106 SSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSK 165
+S S +S++S DK G K+KK + S+ + E E + + + +
Sbjct: 1298 EASVSPEKTSTTSKGKAKRDKASGD-VKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGD 1356
Query: 166 DGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKK 225
K K K S KRK E K E+ + KK S+++ E ++K KKK
Sbjct: 1357 QSNPKSKKEKKKSDKRKKDKEKK-------------EKKKKAKKASTKDSESPSQKKKKK 1403
Query: 226 KK 227
KK
Sbjct: 1404 KK 1405
Score = 57.8 bits (138), Expect = 9e-09
Identities = 44/175 (25%), Positives = 78/175 (44%), Gaps = 25/175 (14%)
Query: 73 LEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRR 132
LE+ R+K++ ++ SS+K +K K + ++ + S +
Sbjct: 1247 LEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRS--------------------K 1286
Query: 133 KKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSS 192
KKKK + + E+S+S ++ + K K+ G KEK KG + E +
Sbjct: 1287 KKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQ 1346
Query: 193 ESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSSPDSP 247
+ + E ++ K KK ++ +K +KK K KK KKK KKA++ +SP
Sbjct: 1347 KGMGTVEGGDQSNPKSKKEKKKSDK-----RKKDKEKKEKKKKAKKASTKDSESP 1396
Score = 48.9 bits (115), Expect = 4e-06
Identities = 38/149 (25%), Positives = 68/149 (45%), Gaps = 18/149 (12%)
Query: 38 RPTWEEVKEQLEKKKKGSKA-LAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKK 96
R WE K +L + ++ ++ ++K+ E EK + S+ +K+ +
Sbjct: 1263 RKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGD 1322
Query: 97 EKKKSGRYSSSSSSSSDS---------------SSSSSDSEDEDKKQGKRRK--KKKNRS 139
K+K G+ S S + D S+ S+ E KK KR+K +KK +
Sbjct: 1323 VKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKK 1382
Query: 140 HKSSESSMSETESDSKDSLKKKKKSKDGT 168
K+ ++S ++ES S+ KKKKK+ + T
Sbjct: 1383 KKAKKASTKDSESPSQKKKKKKKKTAEQT 1411
Score = 37.7 bits (86), Expect = 0.009
Identities = 26/112 (23%), Positives = 48/112 (42%), Gaps = 9/112 (8%)
Query: 42 EEVKEQLEKKKKGSKALAEFEEKM------NENWKKELEKHREKLLSGSESSSKKRQRKK 95
E+ + K K KA + +EK ++ K E E+ +K + E + + K
Sbjct: 1304 EKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSK 1363
Query: 96 KEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSM 147
KEKKKS + + S + + +++KKKK K++E ++
Sbjct: 1364 KEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKKK---KKTAEQTV 1412
Score = 31.6 bits (70), Expect = 0.67
Identities = 21/75 (28%), Positives = 39/75 (52%), Gaps = 2/75 (2%)
Query: 84 SESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSED--EDKKQGKRRKKKKNRSHK 141
++ ++K R+ K E +++ + SS S DSS SSS SE+ E + K +
Sbjct: 1042 AKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPS 1101
Query: 142 SSESSMSETESDSKD 156
+E+ + ET ++S +
Sbjct: 1102 RTETLVEETAAESSE 1116
Score = 30.8 bits (68), Expect = 1.1
Identities = 47/242 (19%), Positives = 87/242 (35%), Gaps = 31/242 (12%)
Query: 34 LNRPRPTWEEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLS------GSESS 87
L R R E+ Q +K + + E + E K +L S G++
Sbjct: 59 LGRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLP 118
Query: 88 SKKRQRKKKEKKKSGRYSSS---------------------SSSSSDSSSSSSDSEDEDK 126
S +++ K E +K+G+ +S S+ S +++ S++E+E
Sbjct: 119 SSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGS 178
Query: 127 KQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSK--KRKMY 184
K S SE S S D + K+ + + + +K K
Sbjct: 179 VPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGA 238
Query: 185 SEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKK--HKKHSKKKKKKAASS 242
+ P + +++ + + SSEE + E+T K K S K + A+S
Sbjct: 239 TPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAAS 298
Query: 243 SP 244
+P
Sbjct: 299 AP 300
Score = 29.6 bits (65), Expect = 2.5
Identities = 35/161 (21%), Positives = 64/161 (39%), Gaps = 23/161 (14%)
Query: 109 SSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSH-------------KSSESSMSETESDSK 155
+S S + SSSS+SEDED + R++ K+S + S ++ S+
Sbjct: 912 ASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSR 971
Query: 156 DSLKKKKKSKDGTEKEKD----------IKGLSKKRKMYSEDKPLSSESLSESEYIEEVR 205
S KK++ +K+ +K L++K + S + +
Sbjct: 972 ISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLP 1031
Query: 206 AKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSSPDS 246
A +S+ + K T K +K K + K +++ S DS
Sbjct: 1032 ATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDS 1072
Score = 28.5 bits (62), Expect = 5.6
Identities = 34/138 (24%), Positives = 57/138 (41%), Gaps = 20/138 (14%)
Query: 107 SSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKD 166
+ SSS D+SSSS +++ E K K + + + T + + ++K
Sbjct: 196 ADSSSEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKA 255
Query: 167 GTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKK 226
G + ED SSE S+SE EE A K + + KA+ KT +
Sbjct: 256 GKPE---------------EDSESSSEESSDSE--EETPAAK---ALLQAKASGKTSQVG 295
Query: 227 KHKKHSKKKKKKAASSSP 244
+K+ +K A+ +P
Sbjct: 296 AASAPAKESPRKGAAPAP 313
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.293 0.111 0.278
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,780,353
Number of Sequences: 37866
Number of extensions: 520976
Number of successful extensions: 33749
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1307
Number of HSP's successfully gapped in prelim test: 1366
Number of HSP's that attempted gapping in prelim test: 5802
Number of HSP's gapped (non-prelim): 12709
length of query: 247
length of database: 18,247,518
effective HSP length: 100
effective length of query: 147
effective length of database: 14,460,918
effective search space: 2125754946
effective search space used: 2125754946
T: 11
A: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 44 (21.7 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.