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Search of human proteins with 85838511
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|85838511 mitogen-activated protein kinase kinase kinase 2
[Homo sapiens]
(619 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|85838511 mitogen-activated protein kinase kinase kinase 2 [Ho... 1253 0.0
gi|42794765 mitogen-activated protein kinase kinase kinase 3 iso... 799 0.0
gi|42794767 mitogen-activated protein kinase kinase kinase 3 iso... 787 0.0
gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo sa... 234 2e-61
gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo sa... 234 2e-61
gi|153945765 mitogen-activated protein kinase kinase kinase 1 [H... 199 8e-51
gi|55956904 mitogen-activated protein kinase kinase kinase 4 iso... 186 6e-47
gi|55956902 mitogen-activated protein kinase kinase kinase 4 iso... 186 6e-47
gi|121583542 mitogen-activated protein kinase kinase kinase 15 [... 167 3e-41
gi|5174547 mitogen-activated protein kinase kinase kinase 5 [Hom... 162 9e-40
gi|45827809 mitogen-activated protein kinase kinase kinase 6 [Ho... 160 3e-39
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 155 1e-37
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 154 2e-37
gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens] 152 1e-36
gi|32483399 p21-activated kinase 2 [Homo sapiens] 150 3e-36
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 150 4e-36
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 150 4e-36
gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens] 149 6e-36
gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens] 149 6e-36
gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens] 149 6e-36
gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens] 149 6e-36
gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens] 149 6e-36
gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens] 149 6e-36
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 149 1e-35
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 148 2e-35
gi|38570135 mitogen-activated protein kinase kinase kinase kinas... 147 4e-35
gi|14589909 mitogen-activated protein kinase kinase kinase kinas... 147 4e-35
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 147 4e-35
gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens] 146 6e-35
gi|110611908 mitogen-activated protein kinase kinase kinase kina... 145 1e-34
>gi|85838511 mitogen-activated protein kinase kinase kinase 2 [Homo
sapiens]
Length = 619
Score = 1253 bits (3241), Expect = 0.0
Identities = 619/619 (100%), Positives = 619/619 (100%)
Query: 1 MDDQQALNSIMQDLAVLHKASRPALSLQETRKAKSSSPKKQNDVRVKFEHRGEKRILQFP 60
MDDQQALNSIMQDLAVLHKASRPALSLQETRKAKSSSPKKQNDVRVKFEHRGEKRILQFP
Sbjct: 1 MDDQQALNSIMQDLAVLHKASRPALSLQETRKAKSSSPKKQNDVRVKFEHRGEKRILQFP 60
Query: 61 RPVKLEDLRSKAKIAFGQSMDLHYTNNELVIPLTTQDDLDKAVELLDRSIHMKSLKILLV 120
RPVKLEDLRSKAKIAFGQSMDLHYTNNELVIPLTTQDDLDKAVELLDRSIHMKSLKILLV
Sbjct: 61 RPVKLEDLRSKAKIAFGQSMDLHYTNNELVIPLTTQDDLDKAVELLDRSIHMKSLKILLV 120
Query: 121 INGSTQATNLEPLPSLEDLDNTVFGAERKKRLSIIGPTSRDRSSPPPGYIPDELHQVARN 180
INGSTQATNLEPLPSLEDLDNTVFGAERKKRLSIIGPTSRDRSSPPPGYIPDELHQVARN
Sbjct: 121 INGSTQATNLEPLPSLEDLDNTVFGAERKKRLSIIGPTSRDRSSPPPGYIPDELHQVARN 180
Query: 181 GSFTSINSEGEFIPESMDQMLDPLSLSSPENSGSGSCPSLDSPLDGESYPKSRMPRAQSY 240
GSFTSINSEGEFIPESMDQMLDPLSLSSPENSGSGSCPSLDSPLDGESYPKSRMPRAQSY
Sbjct: 181 GSFTSINSEGEFIPESMDQMLDPLSLSSPENSGSGSCPSLDSPLDGESYPKSRMPRAQSY 240
Query: 241 PDNHQEFSDYDNPIFEKFGKGGTYPRRYHVSYHHQEYNDGRKTFPRARRTQGTSLRSPVS 300
PDNHQEFSDYDNPIFEKFGKGGTYPRRYHVSYHHQEYNDGRKTFPRARRTQGTSLRSPVS
Sbjct: 241 PDNHQEFSDYDNPIFEKFGKGGTYPRRYHVSYHHQEYNDGRKTFPRARRTQGTSLRSPVS 300
Query: 301 FSPTDHSLSTSSGSSIFTPEYDDSRIRRRGSDIDNPTLTVMDISPPSRSPRAPTNWRLGK 360
FSPTDHSLSTSSGSSIFTPEYDDSRIRRRGSDIDNPTLTVMDISPPSRSPRAPTNWRLGK
Sbjct: 301 FSPTDHSLSTSSGSSIFTPEYDDSRIRRRGSDIDNPTLTVMDISPPSRSPRAPTNWRLGK 360
Query: 361 LLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQ 420
LLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQ
Sbjct: 361 LLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQ 420
Query: 421 YYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIV 480
YYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIV
Sbjct: 421 YYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIV 480
Query: 481 HRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGR 540
HRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGR
Sbjct: 481 HRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGR 540
Query: 541 KADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVE 600
KADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVE
Sbjct: 541 KADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVE 600
Query: 601 AKLRPSADELLRHMFVHYH 619
AKLRPSADELLRHMFVHYH
Sbjct: 601 AKLRPSADELLRHMFVHYH 619
>gi|42794765 mitogen-activated protein kinase kinase kinase 3
isoform 2 [Homo sapiens]
Length = 626
Score = 799 bits (2064), Expect = 0.0
Identities = 410/628 (65%), Positives = 482/628 (76%), Gaps = 20/628 (3%)
Query: 1 MDDQQALNSIMQDLAVLHKASRPALSLQETRKAKSSS-PKKQNDVRVKFEHRGEKRILQF 59
MD+Q+ALNSIM DL L R + ET K K + +Q+DVR+KFEH GE+RI+ F
Sbjct: 1 MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQSDVRIKFEHNGERRIIAF 60
Query: 60 PRPVKLEDLRSKAKIAFGQSMDLHYTNNELVIPLTTQDDLDKAVELLDRSIHMKSLKILL 119
RPVK ED+ K FGQ +DLHY NNEL I L QDDLDKA+++LDRS MKSL+ILL
Sbjct: 61 SRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILL 120
Query: 120 VI-----------NGSTQATNLEPLPSLEDLDNTVFGAERKKRLSIIGPTSRDRSSPPPG 168
+ +G ++ ++ S D++ E + R + + RSSPPPG
Sbjct: 121 LSQDRNHNSSSPHSGVSRQVRIKASQSAGDINTIYQPPEPRSRHLSVSSQNPGRSSPPPG 180
Query: 169 YIPDELHQVARNGSFTSINSEGEFIPESMDQ-MLDPLSLSSPENSGSGSCPSLDSPLDGE 227
Y+P+ +AR GS+TSINSEGEFIPE+ +Q MLDPLS S ENS SGSC SLD D
Sbjct: 181 YVPERQQHIARQGSYTSINSEGEFIPETSEQCMLDPLS--SAENSLSGSCQSLDRSADSP 238
Query: 228 SYPKSRMPRAQSYPDNHQEFSDYDNPIFEKFGKGGTYPRRYHVSYHHQEYNDGRKTFPRA 287
S+ KSRM RAQS+PDN QE+SD + +++K KGGTYPRRYHVS HH++Y+DGR+TFPR
Sbjct: 239 SFRKSRMSRAQSFPDNRQEYSDRETQLYDKGVKGGTYPRRYHVSVHHKDYSDGRRTFPRI 298
Query: 288 RRTQGTSLRSPVSFSPTDHSLSTSSGSSIFTPEYDDSRIRRRGSDIDNPTLTVMDISPPS 347
RR QG + P+ SLST+ + +Y D R R R +D +N L+V + + P+
Sbjct: 299 RRHQGNLF----TLVPSSRSLSTNGENMGLAVQYLDPRGRLRSADSEN-ALSVQERNVPT 353
Query: 348 RSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEI 407
+SP AP NWR GKLLGQGAFGRVYLCYDVDTGRELA KQVQFDPDSPETSKEV+ALECEI
Sbjct: 354 KSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEI 413
Query: 408 QLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQI 467
QLLKNL HERIVQYYGCLRD EKTL+IFMEYMPGGS+KDQLKAYGALTE+VTRKYTRQI
Sbjct: 414 QLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQI 473
Query: 468 LEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYW 527
LEG+ YLHSNMIVHRDIKGANILRDS GNVKLGDFGASKRLQTIC+SGTGM+SVTGTPYW
Sbjct: 474 LEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYW 533
Query: 528 MSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVS 587
MSPEVISGEGYGRKAD+WS+ CTVVEMLTEKPPWAE+EAMAAIFKIATQPTNP+LP H+S
Sbjct: 534 MSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHIS 593
Query: 588 DYTRDFLKRIFVEAKLRPSADELLRHMF 615
++ RDFL+RIFVEA+ RPSA+ELL H F
Sbjct: 594 EHGRDFLRRIFVEARQRPSAEELLTHHF 621
>gi|42794767 mitogen-activated protein kinase kinase kinase 3
isoform 1 [Homo sapiens]
Length = 657
Score = 787 bits (2033), Expect = 0.0
Identities = 413/659 (62%), Positives = 483/659 (73%), Gaps = 51/659 (7%)
Query: 1 MDDQQALNSIMQDLAVLHKASRPALSLQETRKAK----SSSPKKQN-------------- 42
MD+Q+ALNSIM DL L R + ET K K S+ KK N
Sbjct: 1 MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQKKHNSSSSALLNSPTVTT 60
Query: 43 --------------DVRVKFEHRGEKRILQFPRPVKLEDLRSKAKIAFGQSMDLHYTNNE 88
DVR+KFEH GE+RI+ F RPVK ED+ K FGQ +DLHY NNE
Sbjct: 61 SSCAGASEKKKFLSDVRIKFEHNGERRIIAFSRPVKYEDVEHKVTTVFGQPLDLHYMNNE 120
Query: 89 LVIPLTTQDDLDKAVELLDRSIHMKSLKILLVI-----------NGSTQATNLEPLPSLE 137
L I L QDDLDKA+++LDRS MKSL+ILL+ +G ++ ++ S
Sbjct: 121 LSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAG 180
Query: 138 DLDNTVFGAERKKRLSIIGPTSRDRSSPPPGYIPDELHQVARNGSFTSINSEGEFIPESM 197
D++ E + R + + RSSPPPGY+P+ +AR GS+TSINSEGEFIPE+
Sbjct: 181 DINTIYQPPEPRSRHLSVSSQNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETS 240
Query: 198 DQ-MLDPLSLSSPENSGSGSCPSLDSPLDGESYPKSRMPRAQSYPDNHQEFSDYDNPIFE 256
+Q MLDPLS S ENS SGSC SLD D S+ KSRM RAQS+PDN QE+SD + +++
Sbjct: 241 EQCMLDPLS--SAENSLSGSCQSLDRSADSPSFRKSRMSRAQSFPDNRQEYSDRETQLYD 298
Query: 257 KFGKGGTYPRRYHVSYHHQEYNDGRKTFPRARRTQGTSLRSPVSFSPTDHSLSTSSGSSI 316
K KGGTYPRRYHVS HH++Y+DGR+TFPR RR QG + P+ SLST+ +
Sbjct: 299 KGVKGGTYPRRYHVSVHHKDYSDGRRTFPRIRRHQGNLF----TLVPSSRSLSTNGENMG 354
Query: 317 FTPEYDDSRIRRRGSDIDNPTLTVMDISPPSRSPRAPTNWRLGKLLGQGAFGRVYLCYDV 376
+Y D R R R +D +N L+V + + P++SP AP NWR GKLLGQGAFGRVYLCYDV
Sbjct: 355 LAVQYLDPRGRLRSADSEN-ALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDV 413
Query: 377 DTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIF 436
DTGRELA KQVQFDPDSPETSKEV+ALECEIQLLKNL HERIVQYYGCLRD EKTL+IF
Sbjct: 414 DTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIF 473
Query: 437 MEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGN 496
MEYMPGGS+KDQLKAYGALTE+VTRKYTRQILEG+ YLHSNMIVHRDIKGANILRDS GN
Sbjct: 474 MEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGN 533
Query: 497 VKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLT 556
VKLGDFGASKRLQTIC+SGTGM+SVTGTPYWMSPEVISGEGYGRKAD+WS+ CTVVEMLT
Sbjct: 534 VKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLT 593
Query: 557 EKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVEAKLRPSADELLRHMF 615
EKPPWAE+EAMAAIFKIATQPTNP+LP H+S++ RDFL+RIFVEA+ RPSA+ELL H F
Sbjct: 594 EKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIFVEARQRPSAEELLTHHF 652
>gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo
sapiens]
Length = 1328
Score = 234 bits (597), Expect = 2e-61
Identities = 136/280 (48%), Positives = 175/280 (62%), Gaps = 11/280 (3%)
Query: 344 SPPSRSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSP-ETSKEVNA 402
S S P W G++LG+GA+G VY C G+ +AVKQV D + KE
Sbjct: 1049 SENSLKSEEPILWTKGEILGKGAYGTVY-CGLTSQGQLIAVKQVALDTSNKLAAEKEYRK 1107
Query: 403 LECEIQLLKNLLHERIVQYYG-CLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTR 461
L+ E+ LLK L H IV Y G CL QE T+SIFME++PGGSI + +G L E V
Sbjct: 1108 LQEEVDLLKALKHVNIVAYLGTCL---QENTVSIFMEFVPGGSISSIINRFGPLPEMVFC 1164
Query: 462 KYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTG---M 518
KYT+QIL+GV YLH N +VHRDIKG N++ TG +KL DFG ++RL L+GT +
Sbjct: 1165 KYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDML 1224
Query: 519 KSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKI-ATQP 577
KS+ GTPYWM+PEVI+ GYGRK+DIWS+ CTV EM T KPP A + MAA+F I A +
Sbjct: 1225 KSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRG 1284
Query: 578 TNPKLPPHVSDYTRDFLKRIFV-EAKLRPSADELLRHMFV 616
P LP H S+ DF++ + RPSA +LL+H F+
Sbjct: 1285 LMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLKHSFL 1324
>gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo
sapiens]
Length = 510
Score = 234 bits (597), Expect = 2e-61
Identities = 136/280 (48%), Positives = 175/280 (62%), Gaps = 11/280 (3%)
Query: 344 SPPSRSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSP-ETSKEVNA 402
S S P W G++LG+GA+G VY C G+ +AVKQV D + KE
Sbjct: 231 SENSLKSEEPILWTKGEILGKGAYGTVY-CGLTSQGQLIAVKQVALDTSNKLAAEKEYRK 289
Query: 403 LECEIQLLKNLLHERIVQYYG-CLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTR 461
L+ E+ LLK L H IV Y G CL QE T+SIFME++PGGSI + +G L E V
Sbjct: 290 LQEEVDLLKALKHVNIVAYLGTCL---QENTVSIFMEFVPGGSISSIINRFGPLPEMVFC 346
Query: 462 KYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTG---M 518
KYT+QIL+GV YLH N +VHRDIKG N++ TG +KL DFG ++RL L+GT +
Sbjct: 347 KYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDML 406
Query: 519 KSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKI-ATQP 577
KS+ GTPYWM+PEVI+ GYGRK+DIWS+ CTV EM T KPP A + MAA+F I A +
Sbjct: 407 KSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRG 466
Query: 578 TNPKLPPHVSDYTRDFLKRIFV-EAKLRPSADELLRHMFV 616
P LP H S+ DF++ + RPSA +LL+H F+
Sbjct: 467 LMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLKHSFL 506
>gi|153945765 mitogen-activated protein kinase kinase kinase 1 [Homo
sapiens]
Length = 1512
Score = 199 bits (505), Expect = 8e-51
Identities = 115/273 (42%), Positives = 165/273 (60%), Gaps = 15/273 (5%)
Query: 351 RAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPD-SPETSKEVNALECEIQL 409
R T W G+ +G GAF Y DV TG +AVKQV + + S E + V AL EI++
Sbjct: 1238 REDTEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRM 1297
Query: 410 LKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILE 469
+ +L H I++ G + + ++F+E+M GGS+ L YGA E+V YT Q+L
Sbjct: 1298 MSHLNHPNIIRMLGATCE--KSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLR 1355
Query: 470 GVHYLHSNMIVHRDIKGANILRDSTG-NVKLGDFGASKRLQTICLSGTG----MKSVTGT 524
G+ YLH N I+HRD+KGAN+L DSTG +++ DFGA+ RL + GTG + GT
Sbjct: 1356 GLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLAS---KGTGAGEFQGQLLGT 1412
Query: 525 PYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPW-AEFEA--MAAIFKIATQPTNPK 581
+M+PEV+ G+ YGR D+WSV C ++EM KPPW AE + +A IFKIA+ T P
Sbjct: 1413 IAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPS 1472
Query: 582 LPPHVSDYTRDF-LKRIFVEAKLRPSADELLRH 613
+P H+S RD L+ + ++ + RP + ELL+H
Sbjct: 1473 IPSHLSPGLRDVALRCLELQPQDRPPSRELLKH 1505
>gi|55956904 mitogen-activated protein kinase kinase kinase 4 isoform
a [Homo sapiens]
Length = 1608
Score = 186 bits (472), Expect = 6e-47
Identities = 105/266 (39%), Positives = 160/266 (60%), Gaps = 12/266 (4%)
Query: 356 WRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLH 415
W+ G +G+G +G+VY C VDTG +A+K+++F P+ +T KE E+++ + + H
Sbjct: 1343 WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETAD---ELKIFEGIKH 1399
Query: 416 ERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLH 475
+V+Y+G +E + IFMEY G++++ + L E+V R Y++QI ++ LH
Sbjct: 1400 PNLVRYFGVELHREE--MYIFMEYCDEGTLEEVSRL--GLQEHVIRLYSKQITIAINVLH 1455
Query: 476 SNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTG-MKSVTGTPYWMSPEVIS 534
+ IVHRDIKGANI S+G +KLGDFG S +L+ + G + S GT +M+PEVI+
Sbjct: 1456 EHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVIT 1515
Query: 535 ---GEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTR 591
GEG+GR ADIWS+ C V+EM+T K PW E+E I P +P +S +
Sbjct: 1516 RAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGK 1575
Query: 592 DFLKR-IFVEAKLRPSADELLRHMFV 616
DFL + + K+R +A +LL H FV
Sbjct: 1576 DFLSHCLESDPKMRWTASQLLDHSFV 1601
>gi|55956902 mitogen-activated protein kinase kinase kinase 4 isoform
b [Homo sapiens]
Length = 1558
Score = 186 bits (472), Expect = 6e-47
Identities = 105/266 (39%), Positives = 160/266 (60%), Gaps = 12/266 (4%)
Query: 356 WRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLH 415
W+ G +G+G +G+VY C VDTG +A+K+++F P+ +T KE E+++ + + H
Sbjct: 1293 WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETAD---ELKIFEGIKH 1349
Query: 416 ERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLH 475
+V+Y+G +E + IFMEY G++++ + L E+V R Y++QI ++ LH
Sbjct: 1350 PNLVRYFGVELHREE--MYIFMEYCDEGTLEEVSRL--GLQEHVIRLYSKQITIAINVLH 1405
Query: 476 SNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTG-MKSVTGTPYWMSPEVIS 534
+ IVHRDIKGANI S+G +KLGDFG S +L+ + G + S GT +M+PEVI+
Sbjct: 1406 EHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVIT 1465
Query: 535 ---GEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTR 591
GEG+GR ADIWS+ C V+EM+T K PW E+E I P +P +S +
Sbjct: 1466 RAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGK 1525
Query: 592 DFLKR-IFVEAKLRPSADELLRHMFV 616
DFL + + K+R +A +LL H FV
Sbjct: 1526 DFLSHCLESDPKMRWTASQLLDHSFV 1551
>gi|121583542 mitogen-activated protein kinase kinase kinase 15
[Homo sapiens]
Length = 788
Score = 167 bits (422), Expect = 3e-41
Identities = 107/263 (40%), Positives = 153/263 (58%), Gaps = 18/263 (6%)
Query: 361 LLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPET-SKEVNALECEIQLLKNLLHERIV 419
+LG+G +G VY D+ +A+K++ PE S+ L EI L K L H IV
Sbjct: 132 VLGKGTYGIVYAGRDLSNQVRIAIKEI------PERDSRYSQPLHEEIALHKYLKHRNIV 185
Query: 420 QYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKA-YGALTENVTRKYTRQILEGVHYLHSNM 478
QY G + + + IFME +PGGS+ L++ +G + E + YT+QILEG+ YLH N
Sbjct: 186 QYLGSVSE--NGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQ 243
Query: 479 IVHRDIKGANILRDS-TGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVI--SG 535
IVHRDIKG N+L ++ +G VK+ DFG SKRL + ++ TGT +M+PE+I
Sbjct: 244 IVHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGV---NPCTETFTGTLQYMAPEIIDQGP 300
Query: 536 EGYGRKADIWSVACTVVEMLTEKPPWAEF-EAMAAIFKIATQPTNPKLPPHVSDYTRDFL 594
GYG ADIWS+ CT++EM T KPP+ E E AA+FK+ +P++P +S R F+
Sbjct: 301 RGYGAPADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFI 360
Query: 595 KRIF-VEAKLRPSADELLRHMFV 616
F + R + ELLR F+
Sbjct: 361 LSCFEPDPHKRATTAELLREGFL 383
>gi|5174547 mitogen-activated protein kinase kinase kinase 5 [Homo
sapiens]
Length = 1374
Score = 162 bits (410), Expect = 9e-40
Identities = 106/265 (40%), Positives = 156/265 (58%), Gaps = 20/265 (7%)
Query: 361 LLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPET-SKEVNALECEIQLLKNLLHERIV 419
+LG+G +G VY D+ +A+K++ PE S+ L EI L K+L H+ IV
Sbjct: 685 VLGKGTYGIVYAGRDLSNQVRIAIKEI------PERDSRYSQPLHEEIALHKHLKHKNIV 738
Query: 420 QYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKA-YGALTEN--VTRKYTRQILEGVHYLHS 476
QY G + + IFME +PGGS+ L++ +G L +N YT+QILEG+ YLH
Sbjct: 739 QYLGSFSE--NGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHD 796
Query: 477 NMIVHRDIKGANILRDS-TGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVI-- 533
N IVHRDIKG N+L ++ +G +K+ DFG SKRL I ++ TGT +M+PE+I
Sbjct: 797 NQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGI---NPCTETFTGTLQYMAPEIIDK 853
Query: 534 SGEGYGRKADIWSVACTVVEMLTEKPPWAEF-EAMAAIFKIATQPTNPKLPPHVSDYTRD 592
GYG+ ADIWS+ CT++EM T KPP+ E E AA+FK+ +P++P +S +
Sbjct: 854 GPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKA 913
Query: 593 FLKRIF-VEAKLRPSADELLRHMFV 616
F+ + F + R A++LL F+
Sbjct: 914 FILKCFEPDPDKRACANDLLVDEFL 938
>gi|45827809 mitogen-activated protein kinase kinase kinase 6 [Homo
sapiens]
Length = 1288
Score = 160 bits (405), Expect = 3e-39
Identities = 109/265 (41%), Positives = 155/265 (58%), Gaps = 20/265 (7%)
Query: 361 LLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPET-SKEVNALECEIQLLKNLLHERIV 419
+LG+G +G VY D T +A+K++ PE S+ L EI L + L H+ IV
Sbjct: 653 VLGKGTYGVVYAGRDRHTRVRIAIKEI------PERDSRFSQPLHEEIALHRRLRHKNIV 706
Query: 420 QYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKA-YGALTENVTRK--YTRQILEGVHYLHS 476
+Y G Q L IFME +PGGS+ L++ +G L +N + YTRQIL+G+ YLH
Sbjct: 707 RYLGSAS--QGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHD 764
Query: 477 NMIVHRDIKGANILRDS-TGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVI-- 533
N IVHRDIKG N+L ++ +G +K+ DFG SKRL I ++ TGT +M+PE+I
Sbjct: 765 NHIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGIT---PCTETFTGTLQYMAPEIIDQ 821
Query: 534 SGEGYGRKADIWSVACTVVEMLTEKPPWAEF-EAMAAIFKIATQPTNPKLPPHVSDYTRD 592
GYG+ ADIWS+ CTV+EM T +PP+ E AA+F++ +P +P +S +
Sbjct: 822 GPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPMPSSLSAEAQA 881
Query: 593 FLKRIF-VEAKLRPSADELLRHMFV 616
FL R F + +LR SA LL F+
Sbjct: 882 FLLRTFEPDPRLRASAQTLLGDPFL 906
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 155 bits (392), Expect = 1e-37
Identities = 97/259 (37%), Positives = 142/259 (54%), Gaps = 17/259 (6%)
Query: 362 LGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALE-CEIQLLKNLLHERIVQ 420
LG+G++G VY +TG+ +A+KQV + D E KE++ ++ C+ +V+
Sbjct: 36 LGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCD--------SPHVVK 87
Query: 421 YYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYG-ALTENVTRKYTRQILEGVHYLHSNMI 479
YYG + L I MEY GS+ D ++ LTE+ + L+G+ YLH
Sbjct: 88 YYGSYF--KNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRK 145
Query: 480 VHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYG 539
+HRDIK NIL ++ G+ KL DFG + +L +V GTP+WM+PEVI GY
Sbjct: 146 IHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK---RNTVIGTPFWMAPEVIQEIGYN 202
Query: 540 RKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHV-SDYTRDFLKRIF 598
ADIWS+ T +EM KPP+A+ M AIF I T P P + SD DF+K+
Sbjct: 203 CVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCL 262
Query: 599 VEA-KLRPSADELLRHMFV 616
V++ + R +A +LL+H FV
Sbjct: 263 VKSPEQRATATQLLQHPFV 281
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 154 bits (389), Expect = 2e-37
Identities = 97/272 (35%), Positives = 147/272 (54%), Gaps = 17/272 (6%)
Query: 355 NWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLL 414
++ L + +G G +G VY +V+TG A+K ++ +P ++ ++ EI ++K+
Sbjct: 15 DFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEP-----GEDFAVVQQEIIMMKDCK 69
Query: 415 HERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYL 474
H IV Y+G + L I ME+ GGS++D G L+E +R+ L+G++YL
Sbjct: 70 HPNIVAYFGSYL--RRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYL 127
Query: 475 HSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVIS 534
HS +HRDIKGANIL G+VKL DFG S ++ KS GTPYWM+PEV +
Sbjct: 128 HSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAK---RKSFIGTPYWMAPEVAA 184
Query: 535 GE---GYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIF---KIATQPTNPKLPPHVSD 588
E GY + D+W+V T +E+ +PP + M A+F K QP K S+
Sbjct: 185 VERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSN 244
Query: 589 YTRDFLKRIFVE-AKLRPSADELLRHMFVHYH 619
F+K + K RP+A++LL+H FV H
Sbjct: 245 SFHHFVKMALTKNPKKRPTAEKLLQHPFVTQH 276
>gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens]
Length = 545
Score = 152 bits (383), Expect = 1e-36
Identities = 95/258 (36%), Positives = 143/258 (55%), Gaps = 15/258 (5%)
Query: 362 LGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQY 421
+GQGA G VY DV TG+E+A+KQ+ P+ +N EI +++ + IV Y
Sbjct: 276 IGQGASGTVYTAMDVATGQEVAIKQMNLQ-QQPKKELIIN----EILVMRENKNPNIVNY 330
Query: 422 YGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVH 481
E L + MEY+ GGS+ D + + E R+ L+ + +LHSN ++H
Sbjct: 331 LDSYLVGDE--LWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALEFLHSNQVIH 387
Query: 482 RDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRK 541
RDIK NIL G+VKL DFG ++ + ++ GTPYWM+PEV++ + YG K
Sbjct: 388 RDIKSDNILLGMDGSVKLTDFGFCAQITP---EQSKRSTMVGTPYWMAPEVVTRKAYGPK 444
Query: 542 ADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKL--PPHVSDYTRDFLKR-IF 598
DIWS+ +EM+ +PP+ + A++ IAT T P+L P +S RDFL R +
Sbjct: 445 VDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGT-PELQNPEKLSAIFRDFLNRCLE 503
Query: 599 VEAKLRPSADELLRHMFV 616
++ + R SA ELL+H F+
Sbjct: 504 MDVEKRGSAKELLQHQFL 521
>gi|32483399 p21-activated kinase 2 [Homo sapiens]
Length = 524
Score = 150 bits (380), Expect = 3e-36
Identities = 132/499 (26%), Positives = 218/499 (43%), Gaps = 45/499 (9%)
Query: 129 NLEPLPSLEDLDNTVFGAERKKRLSIIGPT---SRDRSSPPPGYIPDELHQVARNGSFTS 185
+L+PLPS+ + R K +SI T S+ + P P + + F +
Sbjct: 36 SLKPLPSVPEEKKP-----RHKIISIFSGTEKGSKKKEKERPEISPPSDFEHTIHVGFDA 90
Query: 186 INSEGEFIPESMDQMLDPLSLSSPENSGSGSC-----PSLDSPLDGESYPKSRMPRAQSY 240
+ E +PE ++L +++ E + DS + Y P +
Sbjct: 91 VTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSNTVKQKYLSFTPPEKDGF 150
Query: 241 PDNHQEFSDYDNPIFEKFGKGGTYPRRYHVSYHHQEYNDGRKTFPRARRTQGTSLRSPVS 300
P + KG P E PR T+ RS +
Sbjct: 151 PSGTPALN----------AKGTEAPAVVTEEEDDDEETAPPVIAPRPDHTKSIYTRSVID 200
Query: 301 FSPTDHSLSTSSGSSIFTPEYDDSRIRRRGSDIDNPTLTVMDISPPSRSPRAPTNWRLGK 360
P S G++ + + + + +I T++ I P + + +
Sbjct: 201 PVPAPVGDSHVDGAAK-SLDKQKKKTKMTDEEIMEKLRTIVSIGDPKKK------YTRYE 253
Query: 361 LLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQ 420
+GQGA G V+ DV G+E+A+KQ+ P+ +N EI ++K L + IV
Sbjct: 254 KIGQGASGTVFTATDVALGQEVAIKQINLQKQ-PKKELIIN----EILVMKELKNPNIVN 308
Query: 421 YYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIV 480
+ E L + MEY+ GGS+ D + + E R+ L+ + +LH+N ++
Sbjct: 309 FLDSYLVGDE--LFVVMEYLAGGSLTDVVTET-CMDEAQIAAVCRECLQALEFLHANQVI 365
Query: 481 HRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGR 540
HRDIK N+L G+VKL DFG ++ + ++ GTPYWM+PEV++ + YG
Sbjct: 366 HRDIKSDNVLLGMEGSVKLTDFGFCAQITP---EQSKRSTMVGTPYWMAPEVVTRKAYGP 422
Query: 541 KADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKL--PPHVSDYTRDFLKR-I 597
K DIWS+ +EM+ +PP+ + A++ IAT T P+L P +S RDFL R +
Sbjct: 423 KVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGT-PELQNPEKLSPIFRDFLNRCL 481
Query: 598 FVEAKLRPSADELLRHMFV 616
++ + R SA ELL+H F+
Sbjct: 482 EMDVEKRGSAKELLQHPFL 500
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 150 bits (378), Expect = 4e-36
Identities = 96/259 (37%), Positives = 140/259 (54%), Gaps = 18/259 (6%)
Query: 362 LGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQY 421
+G+G+FG V+ D T + +A+K + D E E+ ++ EI +L + +Y
Sbjct: 30 IGKGSFGEVFKGIDNRTQKVVAIKII----DLEEAEDEIEDIQQEITVLSQCDSPYVTKY 85
Query: 422 YGC-LRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIV 480
YG L+D + L I MEY+ GGS D L+ G L E R+IL+G+ YLHS +
Sbjct: 86 YGSYLKDTK---LWIIMEYLGGGSALDLLEP-GPLDETQIATILREILKGLDYLHSEKKI 141
Query: 481 HRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGR 540
HRDIK AN+L G VKL DFG + +L + + GTP+WM+PEVI Y
Sbjct: 142 HRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIK---RNTFVGTPFWMAPEVIKQSAYDS 198
Query: 541 KADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTN--PKLPPHVSDYTRDFLKR-I 597
KADIWS+ T +E+ +PP +E M +F I P N P L + S ++F++ +
Sbjct: 199 KADIWSLGITAIELARGEPPHSELHPMKVLFLI---PKNNPPTLEGNYSKPLKEFVEACL 255
Query: 598 FVEAKLRPSADELLRHMFV 616
E RP+A ELL+H F+
Sbjct: 256 NKEPSFRPTAKELLKHKFI 274
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 150 bits (378), Expect = 4e-36
Identities = 96/259 (37%), Positives = 140/259 (54%), Gaps = 18/259 (6%)
Query: 362 LGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQY 421
+G+G+FG V+ D T + +A+K + D E E+ ++ EI +L + +Y
Sbjct: 42 IGKGSFGEVFKGIDNRTQKVVAIKII----DLEEAEDEIEDIQQEITVLSQCDSPYVTKY 97
Query: 422 YGC-LRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIV 480
YG L+D + L I MEY+ GGS D L+ G L E R+IL+G+ YLHS +
Sbjct: 98 YGSYLKDTK---LWIIMEYLGGGSALDLLEP-GPLDETQIATILREILKGLDYLHSEKKI 153
Query: 481 HRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGR 540
HRDIK AN+L G VKL DFG + +L + + GTP+WM+PEVI Y
Sbjct: 154 HRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIK---RNTFVGTPFWMAPEVIKQSAYDS 210
Query: 541 KADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTN--PKLPPHVSDYTRDFLKR-I 597
KADIWS+ T +E+ +PP +E M +F I P N P L + S ++F++ +
Sbjct: 211 KADIWSLGITAIELARGEPPHSELHPMKVLFLI---PKNNPPTLEGNYSKPLKEFVEACL 267
Query: 598 FVEAKLRPSADELLRHMFV 616
E RP+A ELL+H F+
Sbjct: 268 NKEPSFRPTAKELLKHKFI 286
>gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens]
Length = 559
Score = 149 bits (377), Expect = 6e-36
Identities = 94/258 (36%), Positives = 142/258 (55%), Gaps = 15/258 (5%)
Query: 362 LGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQY 421
+GQGA G VY D+ TG+E+A+KQ+ P+ +N EI +++ + IV Y
Sbjct: 289 IGQGASGTVYTALDIATGQEVAIKQMNLQ-QQPKKELIIN----EILVMRENKNPNIVNY 343
Query: 422 YGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVH 481
E L + MEY+ GGS+ D + + E R+ L+ + +LHSN ++H
Sbjct: 344 LDSYLVGDE--LWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQVIH 400
Query: 482 RDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRK 541
RDIK NIL G+VKL DFG ++ + ++ GTPYWM+PEV++ + YG K
Sbjct: 401 RDIKSDNILLGMDGSVKLTDFGFCAQITP---EQSKRSTMVGTPYWMAPEVVTRKAYGPK 457
Query: 542 ADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKL--PPHVSDYTRDFLKR-IF 598
DIWS+ +EM+ +PP+ + A++ IAT T P+L P +S RDFL R +
Sbjct: 458 VDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGT-PELQNPERLSAVFRDFLNRCLE 516
Query: 599 VEAKLRPSADELLRHMFV 616
++ R SA ELL+H F+
Sbjct: 517 MDVDRRGSAKELLQHPFL 534
>gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens]
Length = 565
Score = 149 bits (377), Expect = 6e-36
Identities = 94/258 (36%), Positives = 142/258 (55%), Gaps = 15/258 (5%)
Query: 362 LGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQY 421
+GQGA G VY D+ TG+E+A+KQ+ P+ +N EI +++ + IV Y
Sbjct: 295 IGQGASGTVYTALDIATGQEVAIKQMNLQ-QQPKKELIIN----EILVMRENKNPNIVNY 349
Query: 422 YGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVH 481
E L + MEY+ GGS+ D + + E R+ L+ + +LHSN ++H
Sbjct: 350 LDSYLVGDE--LWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQVIH 406
Query: 482 RDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRK 541
RDIK NIL G+VKL DFG ++ + ++ GTPYWM+PEV++ + YG K
Sbjct: 407 RDIKSDNILLGMDGSVKLTDFGFCAQITP---EQSKRSTMVGTPYWMAPEVVTRKAYGPK 463
Query: 542 ADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKL--PPHVSDYTRDFLKR-IF 598
DIWS+ +EM+ +PP+ + A++ IAT T P+L P +S RDFL R +
Sbjct: 464 VDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGT-PELQNPERLSAVFRDFLNRCLE 522
Query: 599 VEAKLRPSADELLRHMFV 616
++ R SA ELL+H F+
Sbjct: 523 MDVDRRGSAKELLQHPFL 540
>gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens]
Length = 580
Score = 149 bits (377), Expect = 6e-36
Identities = 94/258 (36%), Positives = 142/258 (55%), Gaps = 15/258 (5%)
Query: 362 LGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQY 421
+GQGA G VY D+ TG+E+A+KQ+ P+ +N EI +++ + IV Y
Sbjct: 310 IGQGASGTVYTALDIATGQEVAIKQMNLQ-QQPKKELIIN----EILVMRENKNPNIVNY 364
Query: 422 YGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVH 481
E L + MEY+ GGS+ D + + E R+ L+ + +LHSN ++H
Sbjct: 365 LDSYLVGDE--LWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQVIH 421
Query: 482 RDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRK 541
RDIK NIL G+VKL DFG ++ + ++ GTPYWM+PEV++ + YG K
Sbjct: 422 RDIKSDNILLGMDGSVKLTDFGFCAQITP---EQSKRSTMVGTPYWMAPEVVTRKAYGPK 478
Query: 542 ADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKL--PPHVSDYTRDFLKR-IF 598
DIWS+ +EM+ +PP+ + A++ IAT T P+L P +S RDFL R +
Sbjct: 479 VDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGT-PELQNPERLSAVFRDFLNRCLE 537
Query: 599 VEAKLRPSADELLRHMFV 616
++ R SA ELL+H F+
Sbjct: 538 MDVDRRGSAKELLQHPFL 555
>gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 149 bits (377), Expect = 6e-36
Identities = 94/258 (36%), Positives = 142/258 (55%), Gaps = 15/258 (5%)
Query: 362 LGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQY 421
+GQGA G VY D+ TG+E+A+KQ+ P+ +N EI +++ + IV Y
Sbjct: 274 IGQGASGTVYTALDIATGQEVAIKQMNLQ-QQPKKELIIN----EILVMRENKNPNIVNY 328
Query: 422 YGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVH 481
E L + MEY+ GGS+ D + + E R+ L+ + +LHSN ++H
Sbjct: 329 LDSYLVGDE--LWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQVIH 385
Query: 482 RDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRK 541
RDIK NIL G+VKL DFG ++ + ++ GTPYWM+PEV++ + YG K
Sbjct: 386 RDIKSDNILLGMDGSVKLTDFGFCAQITP---EQSKRSTMVGTPYWMAPEVVTRKAYGPK 442
Query: 542 ADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKL--PPHVSDYTRDFLKR-IF 598
DIWS+ +EM+ +PP+ + A++ IAT T P+L P +S RDFL R +
Sbjct: 443 VDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGT-PELQNPERLSAVFRDFLNRCLE 501
Query: 599 VEAKLRPSADELLRHMFV 616
++ R SA ELL+H F+
Sbjct: 502 MDVDRRGSAKELLQHPFL 519
>gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 149 bits (377), Expect = 6e-36
Identities = 94/258 (36%), Positives = 142/258 (55%), Gaps = 15/258 (5%)
Query: 362 LGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQY 421
+GQGA G VY D+ TG+E+A+KQ+ P+ +N EI +++ + IV Y
Sbjct: 274 IGQGASGTVYTALDIATGQEVAIKQMNLQ-QQPKKELIIN----EILVMRENKNPNIVNY 328
Query: 422 YGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVH 481
E L + MEY+ GGS+ D + + E R+ L+ + +LHSN ++H
Sbjct: 329 LDSYLVGDE--LWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQVIH 385
Query: 482 RDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRK 541
RDIK NIL G+VKL DFG ++ + ++ GTPYWM+PEV++ + YG K
Sbjct: 386 RDIKSDNILLGMDGSVKLTDFGFCAQITP---EQSKRSTMVGTPYWMAPEVVTRKAYGPK 442
Query: 542 ADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKL--PPHVSDYTRDFLKR-IF 598
DIWS+ +EM+ +PP+ + A++ IAT T P+L P +S RDFL R +
Sbjct: 443 VDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGT-PELQNPERLSAVFRDFLNRCLE 501
Query: 599 VEAKLRPSADELLRHMFV 616
++ R SA ELL+H F+
Sbjct: 502 MDVDRRGSAKELLQHPFL 519
>gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 149 bits (377), Expect = 6e-36
Identities = 94/258 (36%), Positives = 142/258 (55%), Gaps = 15/258 (5%)
Query: 362 LGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQY 421
+GQGA G VY D+ TG+E+A+KQ+ P+ +N EI +++ + IV Y
Sbjct: 274 IGQGASGTVYTALDIATGQEVAIKQMNLQ-QQPKKELIIN----EILVMRENKNPNIVNY 328
Query: 422 YGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVH 481
E L + MEY+ GGS+ D + + E R+ L+ + +LHSN ++H
Sbjct: 329 LDSYLVGDE--LWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQVIH 385
Query: 482 RDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRK 541
RDIK NIL G+VKL DFG ++ + ++ GTPYWM+PEV++ + YG K
Sbjct: 386 RDIKSDNILLGMDGSVKLTDFGFCAQITP---EQSKRSTMVGTPYWMAPEVVTRKAYGPK 442
Query: 542 ADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKL--PPHVSDYTRDFLKR-IF 598
DIWS+ +EM+ +PP+ + A++ IAT T P+L P +S RDFL R +
Sbjct: 443 VDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGT-PELQNPERLSAVFRDFLNRCLE 501
Query: 599 VEAKLRPSADELLRHMFV 616
++ R SA ELL+H F+
Sbjct: 502 MDVDRRGSAKELLQHPFL 519
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 149 bits (375), Expect = 1e-35
Identities = 95/261 (36%), Positives = 140/261 (53%), Gaps = 22/261 (8%)
Query: 362 LGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQY 421
+G+G+FG V+ D T + +A+K + D E E+ ++ EI +L + +Y
Sbjct: 30 IGKGSFGEVFKGIDNRTQQVVAIKII----DLEEAEDEIEDIQQEITVLSQCDSSYVTKY 85
Query: 422 YGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVH 481
YG + L I MEY+ GGS D L+A G E ++IL+G+ YLHS +H
Sbjct: 86 YGSYLKGSK--LWIIMEYLGGGSALDLLRA-GPFDEFQIATMLKEILKGLDYLHSEKKIH 142
Query: 482 RDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRK 541
RDIK AN+L G+VKL DFG + +L + + GTP+WM+PEVI Y K
Sbjct: 143 RDIKAANVLLSEQGDVKLADFGVAGQLTDTQIK---RNTFVGTPFWMAPEVIQQSAYDSK 199
Query: 542 ADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVEA 601
ADIWS+ T +E+ +PP ++ M +F I NP P V D+T+ F + F++A
Sbjct: 200 ADIWSLGITAIELAKGEPPNSDMHPMRVLFLI--PKNNP--PTLVGDFTKSF--KEFIDA 253
Query: 602 KL------RPSADELLRHMFV 616
L RP+A ELL+H F+
Sbjct: 254 CLNKDPSFRPTAKELLKHKFI 274
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 148 bits (373), Expect = 2e-35
Identities = 93/259 (35%), Positives = 140/259 (54%), Gaps = 17/259 (6%)
Query: 362 LGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALE-CEIQLLKNLLHERIVQ 420
LG+G++G V+ ++G+ +A+KQV + D E KE++ ++ C+ +V+
Sbjct: 33 LGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPY--------VVK 84
Query: 421 YYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYG-ALTENVTRKYTRQILEGVHYLHSNMI 479
YYG + L I MEY GS+ D ++ L E+ + L+G+ YLH
Sbjct: 85 YYGSYF--KNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRK 142
Query: 480 VHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYG 539
+HRDIK NIL ++ G+ KL DFG + +L +V GTP+WM+PEVI GY
Sbjct: 143 IHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK---RNTVIGTPFWMAPEVIQEIGYN 199
Query: 540 RKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHV-SDYTRDFLKRIF 598
ADIWS+ T +EM KPP+A+ M AIF I T P P + SD DF+K+
Sbjct: 200 CVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCL 259
Query: 599 VE-AKLRPSADELLRHMFV 616
V+ + R +A +LL+H F+
Sbjct: 260 VKNPEQRATATQLLQHPFI 278
>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 147 bits (370), Expect = 4e-35
Identities = 96/272 (35%), Positives = 144/272 (52%), Gaps = 23/272 (8%)
Query: 355 NWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLL 414
++ L + +G G +G VY +V TG AVK ++ +P + + ++ EI ++K
Sbjct: 19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGD-----DFSLIQQEIFMVKECK 73
Query: 415 HERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYL 474
H IV Y+G ++ L I MEY GGS++D G L+E R+ L+G+ YL
Sbjct: 74 HCNIVAYFGSYLSREK--LWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYL 131
Query: 475 HSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVIS 534
H+ +HRDIKGANIL G+VKL DFG + ++ KS GTPYWM+PEV +
Sbjct: 132 HTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAK---RKSFIGTPYWMAPEVAA 188
Query: 535 GE---GYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTR 591
E GY + DIW+V T +E+ +PP + M A+F ++ PP + D T+
Sbjct: 189 VEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQ---PPKLKDKTK 245
Query: 592 ------DFLK-RIFVEAKLRPSADELLRHMFV 616
+F+K + K RP+A+ LL H FV
Sbjct: 246 WSSTFHNFVKIALTKNPKKRPTAERLLTHTFV 277
>gi|14589909 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 147 bits (370), Expect = 4e-35
Identities = 96/272 (35%), Positives = 144/272 (52%), Gaps = 23/272 (8%)
Query: 355 NWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLL 414
++ L + +G G +G VY +V TG AVK ++ +P + + ++ EI ++K
Sbjct: 19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGD-----DFSLIQQEIFMVKECK 73
Query: 415 HERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYL 474
H IV Y+G ++ L I MEY GGS++D G L+E R+ L+G+ YL
Sbjct: 74 HCNIVAYFGSYLSREK--LWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYL 131
Query: 475 HSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVIS 534
H+ +HRDIKGANIL G+VKL DFG + ++ KS GTPYWM+PEV +
Sbjct: 132 HTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAK---RKSFIGTPYWMAPEVAA 188
Query: 535 GE---GYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTR 591
E GY + DIW+V T +E+ +PP + M A+F ++ PP + D T+
Sbjct: 189 VEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQ---PPKLKDKTK 245
Query: 592 ------DFLK-RIFVEAKLRPSADELLRHMFV 616
+F+K + K RP+A+ LL H FV
Sbjct: 246 WSSTFHNFVKIALTKNPKKRPTAERLLTHTFV 277
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 147 bits (370), Expect = 4e-35
Identities = 92/256 (35%), Positives = 137/256 (53%), Gaps = 12/256 (4%)
Query: 362 LGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQY 421
+G+G+FG VY D T +A+K + D E E+ ++ EI +L I +Y
Sbjct: 26 IGKGSFGEVYKGIDNHTKEVVAIKII----DLEEAEDEIEDIQQEITVLSQCDSPYITRY 81
Query: 422 YGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVH 481
+G + L I MEY+ GGS D LK G L E R+IL+G+ YLHS +H
Sbjct: 82 FGSYL--KSTKLWIIMEYLGGGSALDLLKP-GPLEETYIATILREILKGLDYLHSERKIH 138
Query: 482 RDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRK 541
RDIK AN+L G+VKL DFG + +L + + GTP+WM+PEVI Y K
Sbjct: 139 RDIKAANVLLSEQGDVKLADFGVAGQLTDTQIK---RNTFVGTPFWMAPEVIKQSAYDFK 195
Query: 542 ADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKR-IFVE 600
ADIWS+ T +E+ +PP ++ M +F I + + P L S ++F++ + +
Sbjct: 196 ADIWSLGITAIELAKGEPPNSDLHPMRVLFLI-PKNSPPTLEGQHSKPFKEFVEACLNKD 254
Query: 601 AKLRPSADELLRHMFV 616
+ RP+A ELL+H F+
Sbjct: 255 PRFRPTAKELLKHKFI 270
>gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens]
Length = 553
Score = 146 bits (368), Expect = 6e-35
Identities = 93/254 (36%), Positives = 140/254 (55%), Gaps = 15/254 (5%)
Query: 362 LGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQY 421
+GQGA G VY DV TG+E+A+KQ+ P+ +N EI +++ + IV Y
Sbjct: 276 IGQGASGTVYTAMDVATGQEVAIKQMNLQ-QQPKKELIIN----EILVMRENKNPNIVNY 330
Query: 422 YGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVH 481
E L + MEY+ GGS+ D + + E R+ L+ + +LHSN ++H
Sbjct: 331 LDSYLVGDE--LWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALEFLHSNQVIH 387
Query: 482 RDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRK 541
RDIK NIL G+VKL DFG ++ + ++ GTPYWM+PEV++ + YG K
Sbjct: 388 RDIKSDNILLGMDGSVKLTDFGFCAQITP---EQSKRSTMVGTPYWMAPEVVTRKAYGPK 444
Query: 542 ADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKL--PPHVSDYTRDFLKR-IF 598
DIWS+ +EM+ +PP+ + A++ IAT T P+L P +S RDFL R +
Sbjct: 445 VDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGT-PELQNPEKLSAIFRDFLNRCLE 503
Query: 599 VEAKLRPSADELLR 612
++ + R SA ELL+
Sbjct: 504 MDVEKRGSAKELLQ 517
>gi|110611908 mitogen-activated protein kinase kinase kinase kinase
1 isoform 1 [Homo sapiens]
Length = 821
Score = 145 bits (366), Expect = 1e-34
Identities = 100/284 (35%), Positives = 147/284 (51%), Gaps = 18/284 (6%)
Query: 341 MDISPPSRSPRAPTN-WRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKE 399
MD+ P R P + + L + LG G +G V+ D +G +A+K V+ +PD +
Sbjct: 1 MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDD-----D 55
Query: 400 VNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENV 459
V+ L+ EI +LK H IV Y+G Q+ L I ME+ GS++D + G+L+E
Sbjct: 56 VSTLQKEILILKTCRHANIVAYHGSYLWLQK--LWICMEFCGAGSLQDIYQVTGSLSELQ 113
Query: 460 TRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMK 519
R++L+G+ YLHS +HRDIKGANIL + G V+L DFG S ++
Sbjct: 114 ISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATL---ARRL 170
Query: 520 SVTGTPYWMSPEVIS---GEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIF---KI 573
S GTPYWM+PEV + GY DIWS+ T +E+ +PP + + +F K
Sbjct: 171 SFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKS 230
Query: 574 ATQPTNPKLPPHVSDYTRDFLKRIFVEA-KLRPSADELLRHMFV 616
QP K S +F+K ++ K RPSA ++L H V
Sbjct: 231 GYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLV 274
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.391
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,415,038
Number of Sequences: 37866
Number of extensions: 1253890
Number of successful extensions: 6080
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 724
Number of HSP's successfully gapped in prelim test: 99
Number of HSP's that attempted gapping in prelim test: 3625
Number of HSP's gapped (non-prelim): 1055
length of query: 619
length of database: 18,247,518
effective HSP length: 108
effective length of query: 511
effective length of database: 14,157,990
effective search space: 7234732890
effective search space used: 7234732890
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.