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Search of human proteins with 7705383
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7705383 calpain 9 isoform 2 [Homo sapiens]
(664 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7705383 calpain 9 isoform 2 [Homo sapiens] 1357 0.0
gi|5729758 calpain 9 isoform 1 [Homo sapiens] 1340 0.0
gi|27765074 calpain 3 isoform c [Homo sapiens] 779 0.0
gi|27765072 calpain 3 isoform b [Homo sapiens] 745 0.0
gi|4557405 calpain 3 isoform a [Homo sapiens] 741 0.0
gi|12408656 calpain 1, large subunit [Homo sapiens] 712 0.0
gi|47078247 calpain 3 isoform f [Homo sapiens] 695 0.0
gi|157389005 calpain 2 isoform 1 [Homo sapiens] 687 0.0
gi|221554549 calpain 8 [Homo sapiens] 684 0.0
gi|225703100 calpain 2 isoform 2 [Homo sapiens] 651 0.0
gi|215490104 calpain 11 [Homo sapiens] 628 e-180
gi|38707981 calpain 12 [Homo sapiens] 455 e-128
gi|223468608 calpain 14 [Homo sapiens] 435 e-122
gi|37577157 calpain 5 [Homo sapiens] 316 5e-86
gi|41152101 calpain 13 [Homo sapiens] 276 4e-74
gi|27765076 calpain 3 isoform d [Homo sapiens] 270 4e-72
gi|13186316 calpain 6 [Homo sapiens] 258 1e-68
gi|13186302 calpain 10 isoform a [Homo sapiens] 174 2e-43
gi|89353291 calpain 10 isoform c [Homo sapiens] 167 3e-41
gi|14161692 calpain small subunit 2 [Homo sapiens] 166 8e-41
gi|4502565 calpain, small subunit 1 [Homo sapiens] 165 1e-40
gi|51599151 calpain, small subunit 1 [Homo sapiens] 165 1e-40
gi|27765080 calpain 3 isoform e [Homo sapiens] 150 3e-36
gi|27765078 calpain 3 isoform e [Homo sapiens] 150 3e-36
gi|5032105 small optic lobes [Homo sapiens] 126 7e-29
gi|38679884 sorcin isoform b [Homo sapiens] 94 3e-19
gi|4507207 sorcin isoform a [Homo sapiens] 94 3e-19
gi|6912388 grancalcin, EF-hand calcium binding protein [Homo sap... 89 1e-17
gi|7656959 calpain 7 [Homo sapiens] 82 1e-15
gi|6912582 penta-EF-hand domain containing 1 [Homo sapiens] 74 6e-13
>gi|7705383 calpain 9 isoform 2 [Homo sapiens]
Length = 664
Score = 1357 bits (3511), Expect = 0.0
Identities = 664/664 (100%), Positives = 664/664 (100%)
Query: 1 MPYLYRAPGPQAHPVPKDARITHSSGQSFEQMRQECLQRGTLFEDADFPASNSSLFYSER 60
MPYLYRAPGPQAHPVPKDARITHSSGQSFEQMRQECLQRGTLFEDADFPASNSSLFYSER
Sbjct: 1 MPYLYRAPGPQAHPVPKDARITHSSGQSFEQMRQECLQRGTLFEDADFPASNSSLFYSER 60
Query: 61 PQIPFVWKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQD 120
PQIPFVWKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQD
Sbjct: 61 PQIPFVWKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQD 120
Query: 121 QSFGPGYAGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKL 180
QSFGPGYAGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKL
Sbjct: 121 QSFGPGYAGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKL 180
Query: 181 NGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAA 240
NGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAA
Sbjct: 181 NGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAA 240
Query: 241 ESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDRMAFKDFKA 300
ESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDRMAFKDFKA
Sbjct: 241 ESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDRMAFKDFKA 300
Query: 301 HFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQIKLSLTE 360
HFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQIKLSLTE
Sbjct: 301 HFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQIKLSLTE 360
Query: 361 KDEGQEECSFLVALMQKDRRKLKRFGANVLTIGYAIYECPDKDEHLNKDFFRYHASRARS 420
KDEGQEECSFLVALMQKDRRKLKRFGANVLTIGYAIYECPDKDEHLNKDFFRYHASRARS
Sbjct: 361 KDEGQEECSFLVALMQKDRRKLKRFGANVLTIGYAIYECPDKDEHLNKDFFRYHASRARS 420
Query: 421 KTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEKKAITRDMDGNVDIDLPE 480
KTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEKKAITRDMDGNVDIDLPE
Sbjct: 421 KTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEKKAITRDMDGNVDIDLPE 480
Query: 481 PPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFKKLSLISC 540
PPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFKKLSLISC
Sbjct: 481 PPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFKKLSLISC 540
Query: 541 KNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQ 600
KNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQ
Sbjct: 541 KNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQ 600
Query: 601 LSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKNKEFIHLNINEFIHL 660
LSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKNKEFIHLNINEFIHL
Sbjct: 601 LSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKNKEFIHLNINEFIHL 660
Query: 661 TMNI 664
TMNI
Sbjct: 661 TMNI 664
>gi|5729758 calpain 9 isoform 1 [Homo sapiens]
Length = 690
Score = 1340 bits (3468), Expect = 0.0
Identities = 663/690 (96%), Positives = 663/690 (96%), Gaps = 26/690 (3%)
Query: 1 MPYLYRAPGPQAHPVPKDARITHSSGQSFEQMRQECLQRGTLFEDADFPASNSSLFYSER 60
MPYLYRAPGPQAHPVPKDARITHSSGQSFEQMRQECLQRGTLFEDADFPASNSSLFYSER
Sbjct: 1 MPYLYRAPGPQAHPVPKDARITHSSGQSFEQMRQECLQRGTLFEDADFPASNSSLFYSER 60
Query: 61 PQIPFVWKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQD 120
PQIPFVWKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQD
Sbjct: 61 PQIPFVWKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQD 120
Query: 121 QSFGPGYAGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKL 180
QSFGPGYAGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKL
Sbjct: 121 QSFGPGYAGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKL 180
Query: 181 NGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAA 240
NGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAA
Sbjct: 181 NGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAA 240
Query: 241 ESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDR-------- 292
ESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSD
Sbjct: 241 ESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDSSPEWRSVG 300
Query: 293 ------------------MAFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVR 334
MAFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVR
Sbjct: 301 PAEQKRLCHTALDDGEFWMAFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVR 360
Query: 335 GSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEECSFLVALMQKDRRKLKRFGANVLTIGY 394
GSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEECSFLVALMQKDRRKLKRFGANVLTIGY
Sbjct: 361 GSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEECSFLVALMQKDRRKLKRFGANVLTIGY 420
Query: 395 AIYECPDKDEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEAD 454
AIYECPDKDEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEAD
Sbjct: 421 AIYECPDKDEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEAD 480
Query: 455 FCLRIFSEKKAITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAE 514
FCLRIFSEKKAITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAE
Sbjct: 481 FCLRIFSEKKAITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAE 540
Query: 515 ELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLF 574
ELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLF
Sbjct: 541 ELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLF 600
Query: 575 LRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLEN 634
LRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLEN
Sbjct: 601 LRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLEN 660
Query: 635 ASRVFQALSTKNKEFIHLNINEFIHLTMNI 664
ASRVFQALSTKNKEFIHLNINEFIHLTMNI
Sbjct: 661 ASRVFQALSTKNKEFIHLNINEFIHLTMNI 690
>gi|27765074 calpain 3 isoform c [Homo sapiens]
Length = 729
Score = 779 bits (2012), Expect = 0.0
Identities = 376/713 (52%), Positives = 504/713 (70%), Gaps = 59/713 (8%)
Query: 6 RAPGPQAHPVPKDARITHSSG----------------------QSFEQMRQECLQRGTLF 43
R+PGP HP A T + G ++FEQ+ ++CL++ L+
Sbjct: 18 RSPGPVPHPAQSKA--TEAGGGNPSGIYSAIISRNFPIIGVKEKTFEQLHKKCLEKKVLY 75
Query: 44 EDADFPASNSSLFYSERPQIPFVWKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAI 103
D +FP +SLFYS++ I FVWKRP EI +NP FI+ GA RTDICQGELGDCW LAAI
Sbjct: 76 VDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTDICQGELGDCWFLAAI 135
Query: 104 ASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSA 163
A LTLNQ L RVIP DQSF YAGIFHFQFW++ EW+DVVIDD LPT+ ++LVF S
Sbjct: 136 ACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSN 195
Query: 164 DHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKA 223
NEFWSALLEKAYAKL+GSYEALKGG+ EAMEDFTGGVAE F+ ++AP + Y+I++KA
Sbjct: 196 HRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKA 255
Query: 224 LKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWGQV 283
++RGSL+GC IDT + E R GL++GHAYSVTG+D+V F+G++++L+R+RNPWGQV
Sbjct: 256 IERGSLMGCSIDTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPWGQV 315
Query: 284 EWNGSWSDR--------------------------MAFKDFKAHFDKVEICNLTPDALEE 317
EWNGSWSDR M+++DF HF K+EICNLT DAL+
Sbjct: 316 EWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADALQS 375
Query: 318 DAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEE----CSFLVA 373
D + W V+V++G WVRG +AGGCRNF DTFWTNPQ +L L E+D+ ++ CSFLVA
Sbjct: 376 DKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVA 435
Query: 374 LMQKDRRKLKRFGANVLTIGYAIYECPDK----DEHLNKDFFRYHASRARSKTFINLREV 429
LMQK+RRK ++ GA++ TIG+AIYE P + +HL KDFF Y+AS+ARSKT+IN+REV
Sbjct: 436 LMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREV 495
Query: 430 SDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEKKAITRDMDGNVDIDLPEPPKPTPPDQ 489
S RF+LPP EY+++PST+EPHQE +F LR+FSEK+ ++ +++ + +D P P+P DQ
Sbjct: 496 SQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRP-VPQPGSSDQ 554
Query: 490 ETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMDT 549
E+EE+Q+FR +F+Q+AG+DME+ A+EL+ VLN V+ K KD+K +L SC+++I+LMDT
Sbjct: 555 ESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDT 614
Query: 550 SGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLI 609
G+GKL EF W+K+K W +F +D D+SGT+++YE+R A+ AGF L++ L +I
Sbjct: 615 DGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDII 674
Query: 610 VLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKNKEFIHLNINEFIHLTM 662
+RYAD+ + +DFD F+ C VRLE R F A I LN+ E++ LTM
Sbjct: 675 TMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTM 727
>gi|27765072 calpain 3 isoform b [Homo sapiens]
Length = 815
Score = 745 bits (1924), Expect = 0.0
Identities = 377/798 (47%), Positives = 505/798 (63%), Gaps = 143/798 (17%)
Query: 6 RAPGPQAHPVPKDARITHSSG----------------------QSFEQMRQECLQRGTLF 43
R+PGP HP A T + G ++FEQ+ ++CL++ L+
Sbjct: 18 RSPGPVPHPAQSKA--TEAGGGNPSGIYSAIISRNFPIIGVKEKTFEQLHKKCLEKKVLY 75
Query: 44 EDADFPASNSSLFYSERPQIPFVWKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAI 103
D +FP +SLFYS++ I FVWKRP EI +NP FI+ GA RTDICQGELGDCW LAAI
Sbjct: 76 VDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTDICQGELGDCWFLAAI 135
Query: 104 ASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSA 163
A LTLNQ L RVIP DQSF YAGIFHFQFW++ EW+DVVIDD LPT+ ++LVF S
Sbjct: 136 ACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSN 195
Query: 164 DHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKA 223
NEFWSALLEKAYAKL+GSYEALKGG+ EAMEDFTGGVAE F+ ++AP + Y+I++KA
Sbjct: 196 HRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKA 255
Query: 224 LKRGSLLGCFID------------------------------------------------ 235
++RGSL+GC ID
Sbjct: 256 IERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTR 315
Query: 236 TRSAAESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDR--- 292
T + E R GL++GHAYSVTG+D+V F+G++++L+R+RNPWGQVEWNGSWSDR
Sbjct: 316 TIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKD 375
Query: 293 -----------------------MAFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQ 329
M+++DF HF K+EICNLT DAL+ D + W V+V++
Sbjct: 376 WSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNE 435
Query: 330 GSWVRGSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEE----CSFLVALMQKDRRKLKRF 385
G WVRG +AGGCRNF DTFWTNPQ +L L E+D+ ++ CSFLVALMQK+RRK ++
Sbjct: 436 GRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKL 495
Query: 386 GANVLTIGYAIYECPDK----DEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYI 441
GA++ TIG+AIYE P + +HL KDFF Y+AS+ARSKT+IN+REVS RF+LPP EY+
Sbjct: 496 GASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYV 555
Query: 442 LIPSTFEPHQEADFCLRIFSEKKAITRDMDGNVDIDLPEP-------------------- 481
++PST+EPHQE +F LR+FSEK+ ++ +++ + +D P P
Sbjct: 556 IVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPVPIIFVSDRANSNKELGVDQES 615
Query: 482 -----------------PKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVL 524
P+P DQE+EE+Q+FR +F+Q+AG+DME+ A+EL+ VLN V+
Sbjct: 616 EEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVV 675
Query: 525 QKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGT 584
K KD+K +L SC+++I+LMDT G+GKL EF W+K+K W +F +D D+SGT
Sbjct: 676 NKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGT 735
Query: 585 MSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALST 644
+++YE+R A+ AGF L++ L +I +RYAD+ + +DFD F+ C VRLE R F A
Sbjct: 736 INSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDK 795
Query: 645 KNKEFIHLNINEFIHLTM 662
I LN+ E++ LTM
Sbjct: 796 DGDGIIKLNVLEWLQLTM 813
>gi|4557405 calpain 3 isoform a [Homo sapiens]
Length = 821
Score = 741 bits (1913), Expect = 0.0
Identities = 377/804 (46%), Positives = 504/804 (62%), Gaps = 149/804 (18%)
Query: 6 RAPGPQAHPVPKDARITHSSG----------------------QSFEQMRQECLQRGTLF 43
R+PGP HP A T + G ++FEQ+ ++CL++ L+
Sbjct: 18 RSPGPVPHPAQSKA--TEAGGGNPSGIYSAIISRNFPIIGVKEKTFEQLHKKCLEKKVLY 75
Query: 44 EDADFPASNSSLFYSERPQIPFVWKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAI 103
D +FP +SLFYS++ I FVWKRP EI +NP FI+ GA RTDICQGELGDCW LAAI
Sbjct: 76 VDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTDICQGELGDCWFLAAI 135
Query: 104 ASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSA 163
A LTLNQ L RVIP DQSF YAGIFHFQFW++ EW+DVVIDD LPT+ ++LVF S
Sbjct: 136 ACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSN 195
Query: 164 DHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKA 223
NEFWSALLEKAYAKL+GSYEALKGG+ EAMEDFTGGVAE F+ ++AP + Y+I++KA
Sbjct: 196 HRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKA 255
Query: 224 LKRGSLLGCFID------------------------------------------------ 235
++RGSL+GC ID
Sbjct: 256 IERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTR 315
Query: 236 TRSAAESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDR--- 292
T + E R GL++GHAYSVTG+D+V F+G++++L+R+RNPWGQVEWNGSWSDR
Sbjct: 316 TIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKD 375
Query: 293 -----------------------MAFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQ 329
M+++DF HF K+EICNLT DAL+ D + W V+V++
Sbjct: 376 WSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNE 435
Query: 330 GSWVRGSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEE----CSFLVALMQKDRRKLKRF 385
G WVRG +AGGCRNF DTFWTNPQ +L L E+D+ ++ CSFLVALMQK+RRK ++
Sbjct: 436 GRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKL 495
Query: 386 GANVLTIGYAIYECPDK----DEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYI 441
GA++ TIG+AIYE P + +HL KDFF Y+AS+ARSKT+IN+REVS RF+LPP EY+
Sbjct: 496 GASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYV 555
Query: 442 LIPSTFEPHQEADFCLRIFSEKKAITRDMDGNVDIDLPEPPKPTPP-------------- 487
++PST+EPHQE +F LR+FSEK+ ++ +++ + +D P K T P
Sbjct: 556 IVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKEL 615
Query: 488 -----------------------------DQETEEEQRFRALFEQVAGEDMEVTAEELEY 518
DQE+EE+Q+FR +F+Q+AG+DME+ A+EL+
Sbjct: 616 GVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKK 675
Query: 519 VLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFD 578
VLN V+ K KD+K +L SC+++I+LMDT G+GKL EF W+K+K W +F +D
Sbjct: 676 VLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYD 735
Query: 579 ADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRV 638
D+SGT+++YE+R A+ AGF L++ L +I +RYAD+ + +DFD F+ C VRLE R
Sbjct: 736 TDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRA 795
Query: 639 FQALSTKNKEFIHLNINEFIHLTM 662
F A I LN+ E++ LTM
Sbjct: 796 FHAFDKDGDGIIKLNVLEWLQLTM 819
>gi|12408656 calpain 1, large subunit [Homo sapiens]
Length = 714
Score = 712 bits (1838), Expect = 0.0
Identities = 355/678 (52%), Positives = 470/678 (69%), Gaps = 45/678 (6%)
Query: 26 GQSFEQMRQECLQRGTLFEDADFPASNSSLFYSE-----RPQIPFVWKRPGEIVKNPEFI 80
GQ +EQ+R CLQ GTLF D FP SL Y + WKRP E++ NP+FI
Sbjct: 39 GQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFI 98
Query: 81 LGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSE 140
+ GATRTDICQG LGDCWLLAAIASLTLN L RV+P QSF GYAGIFHFQ WQ E
Sbjct: 99 VDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGE 158
Query: 141 WLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFT 200
W+DVV+DD LP +LVF+HSA+ NEFWSALLEKAYAK+NGSYEAL GGS E EDFT
Sbjct: 159 WVDVVVDDLLPIKDGKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFT 218
Query: 201 GGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTG 260
GGV E ++ ++AP + Y+I+ KAL+RGSLLGC ID S + EA T L+KGHAYSVTG
Sbjct: 219 GGVTEWYELRKAPSDLYQIILKALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTG 278
Query: 261 IDQVSFRGQRIELIRIRNPWGQVEWNGSWSDR-------------------------MAF 295
QV++RGQ + LIR+RNPWG+VEW G+WSD M+F
Sbjct: 279 AKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSF 338
Query: 296 KDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQIK 355
+DF F ++EICNLTPDAL+ I KW T+++G+W RGSTAGGCRN+ TFW NPQ K
Sbjct: 339 RDFMREFTRLEICNLTPDALKSRTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFK 398
Query: 356 LSLTEKDE----GQEE--CSFLVALMQKDRRKLKRFGANVLTIGYAIYECPDK-----DE 404
+ L E D+ G E CSF++ALMQK RR+ +RFG ++ TIG+A+YE P +
Sbjct: 399 IRLDETDDPDDYGDRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAV 458
Query: 405 HLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEKK 464
HL +DFF +ASRARS+ FINLREVS RF+LPPGEY+++PSTFEP++E DF LR FSEK
Sbjct: 459 HLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKS 518
Query: 465 AITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVL 524
A T ++D + +LP+ + E E ++ F+ALF Q+AGEDME++ +EL +LN ++
Sbjct: 519 AGTVELDDQIQANLPDEQVLS----EEEIDENFKALFRQLAGEDMEISVKELRTILNRII 574
Query: 525 QKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGT 584
K KD++ K SL SC+++++LMD GNGKL EF + W++++ ++++F +FD DKSG+
Sbjct: 575 SKHKDLRTKGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGS 634
Query: 585 MSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALST 644
MS YE+R A+++AGF+L+ L +LI+ RY++ +L +DFD+F+ CLVRLE R F+ L T
Sbjct: 635 MSAYEMRMAIESAGFKLNKKLYELIITRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDT 694
Query: 645 KNKEFIHLNINEFIHLTM 662
+ ++ +++ LTM
Sbjct: 695 DLDGVVTFDLFKWLQLTM 712
>gi|47078247 calpain 3 isoform f [Homo sapiens]
Length = 728
Score = 695 bits (1794), Expect = 0.0
Identities = 347/714 (48%), Positives = 463/714 (64%), Gaps = 119/714 (16%)
Query: 68 KRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGY 127
++ EI +NP FI+ GA RTDICQGELGDCW LAAIA LTLNQ L RVIP DQSF Y
Sbjct: 13 QQKNEICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENY 72
Query: 128 AGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEAL 187
AGIFHFQFW++ EW+DVVIDD LPT+ ++LVF S NEFWSALLEKAYAKL+GSYEAL
Sbjct: 73 AGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEAL 132
Query: 188 KGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKALKRGSLLGCFID------------ 235
KGG+ EAMEDFTGGVAE F+ ++AP + Y+I++KA++RGSL+GC ID
Sbjct: 133 KGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPS 192
Query: 236 ------------------------------------TRSAAESEARTPFGLIKGHAYSVT 259
T + E R GL++GHAYSVT
Sbjct: 193 GLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVT 252
Query: 260 GIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDR--------------------------M 293
G+D+V F+G++++L+R+RNPWGQVEWNGSWSDR M
Sbjct: 253 GLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWM 312
Query: 294 AFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQ 353
+++DF HF K+EICNLT DAL+ D + W V+V++G WVRG +AGGCRNF DTFWTNPQ
Sbjct: 313 SYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQ 372
Query: 354 IKLSLTEKDEGQEE----CSFLVALMQKDRRKLKRFGANVLTIGYAIYECPDK----DEH 405
+L L E+D+ ++ CSFLVALMQK+RRK ++ GA++ TIG+AIYE P + +H
Sbjct: 373 YRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQH 432
Query: 406 LNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEKKA 465
L KDFF Y+AS+ARSKT+IN+REVS RF+LPP EY+++PST+EPHQE +F LR+FSEK+
Sbjct: 433 LQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRN 492
Query: 466 ITRDMDGNVDIDLPEP-------------------------------------PKPTPPD 488
++ +++ + +D P P P+P D
Sbjct: 493 LSEEVENTISVDRPVPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSD 552
Query: 489 QETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMD 548
QE+EE+Q+FR +F+Q+AG+DME+ A+EL+ VLN V+ K KD+K +L SC+++I+LMD
Sbjct: 553 QESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMD 612
Query: 549 TSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQLSSHLLQL 608
T G+GKL EF W+K+K W +F +D D+SGT+++YE+R A+ AGF L++ L +
Sbjct: 613 TDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDI 672
Query: 609 IVLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKNKEFIHLNINEFIHLTM 662
I +RYAD+ + +DFD F+ C VRLE R F A I LN+ E++ LTM
Sbjct: 673 ITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTM 726
>gi|157389005 calpain 2 isoform 1 [Homo sapiens]
Length = 700
Score = 687 bits (1774), Expect = 0.0
Identities = 340/667 (50%), Positives = 464/667 (69%), Gaps = 44/667 (6%)
Query: 27 QSFEQMRQECLQRGTLFEDADFPASNSSLFYSERPQIP-----FVWKRPGEIVKNPEFIL 81
Q +E +R ECL+ GTLF+D FPA S+L + E WKRP EI +P+FI+
Sbjct: 30 QDYEALRNECLEAGTLFQDPSFPAIPSALGFKELGPYSSKTRGIEWKRPTEICADPQFII 89
Query: 82 GGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEW 141
GGATRTDICQG LGDCWLLAAIASLTLN++ LARV+P +QSF YAGIFHFQFWQ+ EW
Sbjct: 90 GGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIFHFQFWQYGEW 149
Query: 142 LDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTG 201
++VV+DDRLPT L+F+HSA+ +EFWSALLEKAYAK+NG YEAL GG+ E EDFTG
Sbjct: 150 VEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTG 209
Query: 202 GVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTGI 261
G+AE ++ K+ P N ++I++KAL++GSLLGC ID SAA+SEA T L+KGHAYSVTG
Sbjct: 210 GIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKLVKGHAYSVTGA 269
Query: 262 DQVSFRGQRIELIRIRNPWGQVEWNGSWSDR-------------------------MAFK 296
++V G +LIRIRNPWG+VEW G W+D M+F
Sbjct: 270 EEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRRHEDGEFWMSFS 329
Query: 297 DFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQIKL 356
DF H+ ++EICNLTPD L D KW++T G+W RGSTAGGCRN+ +TFW NPQ +
Sbjct: 330 DFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYLI 389
Query: 357 SLTEKDEGQEE----CSFLVALMQKDRRKLKRFGANVLTIGYAIYECPDK-----DEHLN 407
L E+DE +E+ C+FLV L+QK RR+ ++ G ++ TIG+ IYE P++ + HL+
Sbjct: 390 KLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELSGQTNIHLS 449
Query: 408 KDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEKKAIT 467
K+FF + +R RS TFINLREV +RFKLPPGEYIL+PSTFEP+++ DFC+R+FSEKKA
Sbjct: 450 KNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADY 509
Query: 468 RDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQKK 527
+ +D ++ +L E E + + FR LF Q+AGED E++A EL+ +L VL K+
Sbjct: 510 QAVDDEIEANLEE-----FDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKR 564
Query: 528 KDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMST 587
+DIK S+ +CK ++ ++D+ G+GKL EF + W K++++ ++ D D+SGTM++
Sbjct: 565 QDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNS 624
Query: 588 YELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKNK 647
YE+R AL+ AGF++ L Q+IV R+AD++L +DFD+F+ CLVRLE ++F+ L +N
Sbjct: 625 YEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQLDPENT 684
Query: 648 EFIHLNI 654
I L++
Sbjct: 685 GTIELDL 691
>gi|221554549 calpain 8 [Homo sapiens]
Length = 703
Score = 684 bits (1766), Expect = 0.0
Identities = 338/674 (50%), Positives = 460/674 (68%), Gaps = 45/674 (6%)
Query: 26 GQSFEQMRQECLQRGTLFEDADFPASNSSLFYSE----RPQIP-FVWKRPGEIVKNPEFI 80
GQ F+ +RQ+CL G LF+D +FPA S+L Y + PQ +WKRP E+ +P+FI
Sbjct: 29 GQDFKTLRQQCLDSGVLFKDPEFPACPSALGYKDLGPGSPQTQGIIWKRPTELCPSPQFI 88
Query: 81 LGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSE 140
+GGATRTDICQG LGDCWLLAAIASLTLN++ L RV+P+DQ F YAGIFHFQFWQ+ E
Sbjct: 89 VGGATRTDICQGGLGDCWLLAAIASLTLNEELLYRVVPRDQDFQENYAGIFHFQFWQYGE 148
Query: 141 WLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFT 200
W++VVIDDRLPT +L+FLHS NEFWSALLEKAYAKLNG YEAL GGS +E EDFT
Sbjct: 149 WVEVVIDDRLPTKNGQLLFLHSEQGNEFWSALLEKAYAKLNGCYEALAGGSTVEGFEDFT 208
Query: 201 GGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTG 260
GG++E + K+ P N Y+I+ KAL GSLLGC ID SAAE+EA T L+K HAYSVTG
Sbjct: 209 GGISEFYDLKKPPANLYQIIRKALCAGSLLGCSIDVSSAAEAEAITSQKLVKSHAYSVTG 268
Query: 261 IDQVSFRGQRIELIRIRNPWGQVEWNGSWSDR-------------------------MAF 295
+++V+F+G +LIR+RNPWG+VEW+G+WSD M+
Sbjct: 269 VEEVNFQGHPEKLIRLRNPWGEVEWSGAWSDDAPEWNHIDPRRKEELDKKVEDGEFWMSL 328
Query: 296 KDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQIK 355
DF F ++EICNL+PD+L + +HKW + + G W RGSTAGGC+N+ T+WTNPQ K
Sbjct: 329 SDFVRQFSRLEICNLSPDSLSSEEVHKWNLVLFNGHWTRGSTAGGCQNYPATYWTNPQFK 388
Query: 356 LSLTEKDEGQEE------CSFLVALMQKDRRKLKRFGANVLTIGYAIYECPDK-----DE 404
+ L E DE QEE C+ L+ LMQK+RR KR G +L+IGYA+Y+ P + D
Sbjct: 389 IRLDEVDEDQEESIGEPCCTVLLGLMQKNRRWRKRIGQGMLSIGYAVYQVPKELESHTDA 448
Query: 405 HLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEKK 464
HL +DFF + AR+ T++NLREVS R +LPPGEY+++PSTFEP ++ +FCLR+FSEKK
Sbjct: 449 HLGRDFFLAYQPSARTSTYVNLREVSGRARLPPGEYLVVPSTFEPFKDGEFCLRVFSEKK 508
Query: 465 AITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVL 524
A ++ G+V P P P+ DQ E+ +FR LFE++AG+D E+TA L+ +LN
Sbjct: 509 AQALEI-GDVVAGNPYEPHPSEVDQ---EDDQFRRLFEKLAGKDSEITANALKILLNEAF 564
Query: 525 QKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGT 584
K+ DIKF ++ +C+ +ISL+D++G G L EFK W K+++++ ++ D + SGT
Sbjct: 565 SKRTDIKFDGFNINTCREMISLLDSNGTGTLGAVEFKTLWLKIQKYLEIYWETDYNHSGT 624
Query: 585 MSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALST 644
+ +E+RTAL+ AGF L+S + Q I LRYA +L ++FD F+ C++RLE ++F L
Sbjct: 625 IDAHEMRTALRKAGFTLNSQVQQTIALRYACSKLGINFDSFVACMIRLETLFKLFSLLDE 684
Query: 645 KNKEFIHLNINEFI 658
+ L++ E++
Sbjct: 685 DKDGMVQLSLAEWL 698
>gi|225703100 calpain 2 isoform 2 [Homo sapiens]
Length = 622
Score = 651 bits (1680), Expect = 0.0
Identities = 319/617 (51%), Positives = 437/617 (70%), Gaps = 39/617 (6%)
Query: 72 EIVKNPEFILGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIF 131
EI +P+FI+GGATRTDICQG LGDCWLLAAIASLTLN++ LARV+P +QSF YAGIF
Sbjct: 2 EICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIF 61
Query: 132 HFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGS 191
HFQFWQ+ EW++VV+DDRLPT L+F+HSA+ +EFWSALLEKAYAK+NG YEAL GG+
Sbjct: 62 HFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGA 121
Query: 192 AIEAMEDFTGGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLI 251
E EDFTGG+AE ++ K+ P N ++I++KAL++GSLLGC ID SAA+SEA T L+
Sbjct: 122 TTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKLV 181
Query: 252 KGHAYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDR------------------- 292
KGHAYSVTG ++V G +LIRIRNPWG+VEW G W+D
Sbjct: 182 KGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRRH 241
Query: 293 ------MAFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLD 346
M+F DF H+ ++EICNLTPD L D KW++T G+W RGSTAGGCRN+ +
Sbjct: 242 EDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYPN 301
Query: 347 TFWTNPQIKLSLTEKDEGQEE----CSFLVALMQKDRRKLKRFGANVLTIGYAIYECPDK 402
TFW NPQ + L E+DE +E+ C+FLV L+QK RR+ ++ G ++ TIG+ IYE P++
Sbjct: 302 TFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEE 361
Query: 403 -----DEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCL 457
+ HL+K+FF + +R RS TFINLREV +RFKLPPGEYIL+PSTFEP+++ DFC+
Sbjct: 362 LSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCI 421
Query: 458 RIFSEKKAITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELE 517
R+FSEKKA + +D ++ +L E E + + FR LF Q+AGED E++A EL+
Sbjct: 422 RVFSEKKADYQAVDDEIEANLEE-----FDISEDDIDDGFRRLFAQLAGEDAEISAFELQ 476
Query: 518 YVLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRF 577
+L VL K++DIK S+ +CK ++ ++D+ G+GKL EF + W K++++ ++
Sbjct: 477 TILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREI 536
Query: 578 DADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASR 637
D D+SGTM++YE+R AL+ AGF++ L Q+IV R+AD++L +DFD+F+ CLVRLE +
Sbjct: 537 DVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFK 596
Query: 638 VFQALSTKNKEFIHLNI 654
+F+ L +N I L++
Sbjct: 597 IFKQLDPENTGTIELDL 613
>gi|215490104 calpain 11 [Homo sapiens]
Length = 739
Score = 628 bits (1620), Expect = e-180
Identities = 320/678 (47%), Positives = 447/678 (65%), Gaps = 46/678 (6%)
Query: 27 QSFEQMRQECLQRGTLFEDADFPASNSSLFYSER-PQIPFV----WKRPGEIVKNPEFIL 81
QSFE++R CL++G LFED FPA SSL + + P V W+RP +I+ NP FI+
Sbjct: 64 QSFEELRAACLRKGELFEDPLFPAEPSSLGFKDLGPNSKNVQNISWQRPKDIINNPLFIM 123
Query: 82 GGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEW 141
G + TDICQG LGDCWLLAAI SLT K L RV+P+ QSF YAGIFHFQ WQ +W
Sbjct: 124 DGISPTDICQGILGDCWLLAAIGSLTTCPKLLYRVVPRGQSFKKNYAGIFHFQIWQFGQW 183
Query: 142 LDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTG 201
++VV+DDRLPT D+LVF+HS + +EFWSALLEKAYAKL+GSYEAL GGS +E +EDFTG
Sbjct: 184 VNVVVDDRLPTKNDKLVFVHSTERSEFWSALLEKAYAKLSGSYEALSGGSTMEGLEDFTG 243
Query: 202 GVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTGI 261
GVA++FQ + P+N +L KA++R SL+GC I+ S +E E+ T L++GHAYSVTG+
Sbjct: 244 GVAQSFQLQRPPQNLLRLLRKAVERSSLMGCSIEVTSDSELESMTDKMLVRGHAYSVTGL 303
Query: 262 DQVSFRGQRIELIRIRNPWGQVEWNGSWSDR-------------------------MAFK 296
V +RG+ LIR+RNPWG++EWNG+WSD M+++
Sbjct: 304 QDVHYRGKMETLIRVRNPWGRIEWNGAWSDSAREWEEVASDIQMQLLHKTEDGEFWMSYQ 363
Query: 297 DFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQIKL 356
DF +F +EICNLTPD L D W T ++GSW RGS+AGGCRN TFWTNPQ K+
Sbjct: 364 DFLNNFTLLEICNLTPDTLSGDYKSYWHTTFYEGSWRRGSSAGGCRNHPGTFWTNPQFKI 423
Query: 357 SLTEKDEGQEE-------CSFLVALMQKDRRKLKRFGANVLTIGYAIYECPD-----KDE 404
SL E D+ +++ C+ LVALMQK+ R ++ GA + TIG+ +Y P +D
Sbjct: 424 SLPEGDDPEDDAEGNVVVCTCLVALMQKNWRHARQQGAQLQTIGFVLYAVPKEFQNIQDV 483
Query: 405 HLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEKK 464
HL K+FF + S+ F N REVS + +LPPGEYI+IPSTFEPH++ADF LR+F+EK
Sbjct: 484 HLKKEFFTKYQDHGFSEIFTNSREVSSQLRLPPGEYIIIPSTFEPHRDADFLLRVFTEKH 543
Query: 465 AITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVL 524
+ + ++D +++ E + E + +Q F LF+ VAGE E+ EL+ +LN +
Sbjct: 544 SESWELD---EVNYAEQLQEEKV-SEDDMDQDFLHLFKIVAGEGKEIGVYELQRLLNRMA 599
Query: 525 QKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGT 584
K K K K L +C+ +I+LMD G+GKL EFK+ W KLK+W+++F D D SGT
Sbjct: 600 IKFKSFKTKGFGLDACRCMINLMDKDGSGKLGLLEFKILWKKLKKWMDIFRECDQDHSGT 659
Query: 585 MSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALST 644
+++YE+R ++ AG +L++ ++Q++V RYAD++L +DFD F++C +RL+ F +
Sbjct: 660 LNSYEMRLVIEKAGIKLNNKVMQVLVARYADDDLIIDFDSFISCFLRLKTMFTFFLTMDP 719
Query: 645 KNKEFIHLNINEFIHLTM 662
KN I L++ +++ +TM
Sbjct: 720 KNTGHICLSLEQWLQMTM 737
>gi|38707981 calpain 12 [Homo sapiens]
Length = 719
Score = 455 bits (1170), Expect = e-128
Identities = 263/672 (39%), Positives = 369/672 (54%), Gaps = 78/672 (11%)
Query: 26 GQSFEQMRQECLQRGTLFEDADFPASNSSLFY------SERPQIPFVWKRPGEIVKNPEF 79
GQS+E +R CL G LF D FPA +L Y SE+ + W RP E P+F
Sbjct: 29 GQSYEAIRAACLDSGILFRDPYFPAGPDALGYDQLGPDSEKAK-GVKWMRPHEFCAEPKF 87
Query: 80 ILGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHS 139
I +RTD+CQG LG+CW LAA ASLTL + L RV+P Q F GYAG+FHFQ WQ
Sbjct: 88 ICEDMSRTDVCQGSLGNCWFLAAAASLTLYPRLLRRVVPPGQDFQHGYAGVFHFQLWQFG 147
Query: 140 EWLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDF 199
W+DVV+DDRLP +L+F+ S NEFW+ LLEKAYAKL+GSYE ++GG EA DF
Sbjct: 148 RWMDVVVDDRLPVREGKLMFVRSEQRNEFWAPLLEKAYAKLHGSYEVMRGGHMNEAFVDF 207
Query: 200 TGGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVT 259
TGGV E ++ + L AL + SL+G T + E RT GL+KGHAYS+T
Sbjct: 208 TGGVGEVLYLRQNSMGLFSALRHALAKESLVGA---TALSDRGEYRTEEGLVKGHAYSIT 264
Query: 260 GIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDR-------------------------MA 294
G +V ++ L+R+RNPWG VEW G+WSD M
Sbjct: 265 GTHKVFLGFTKVRLLRLRNPWGCVEWTGAWSDSCPRWDTLPTECRDALLVKKEDGEFWME 324
Query: 295 FKDFKAHFDKVEICNLTPDAL-EEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQ 353
+DF HFD V+IC+L+P+ L W V QG WVRG +GG + +TFWTNPQ
Sbjct: 325 LRDFLLHFDTVQICSLSPEVLGPSPEGGGWHVHTFQGRWVRGFNSGGSQPNAETFWTNPQ 384
Query: 354 IKLSLTEKDEGQEE-------------------------CSFLVALMQKDRRKLKRFGAN 388
+L+L E DE +E C+ L++L+Q++RR+L+ G
Sbjct: 385 FRLTLLEPDEEDDEDEEGPWGGWGAAGARGPARGGRTPKCTVLLSLIQRNRRRLRAKGLT 444
Query: 389 VLTIGYAIYECPDKDEHLNKDFFRYHA-----SRARSKTFINLREVSDRFKLPPGEYILI 443
LT+G+ +++ P++ L D R HA RA R+V+ R L PG Y+++
Sbjct: 445 YLTVGFHVFQIPEELLGL-WDSPRSHALLPRLLRADRSPLSARRDVTRRCCLRPGHYLVV 503
Query: 444 PSTFEPHQEADFCLRIFSEKKAITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQ 503
PST EADF LR+FSE++ ++D + DL P P E LF++
Sbjct: 504 PSTAHAGDEADFTLRVFSERRHTAVEIDDVISADLQSLQGPYLP-----LELGLEQLFQE 558
Query: 504 VAGEDMEVTAEELEYVLNAVLQ--KKKDIKFKKLSLISCKNIISLMDTSGNGK-LEFDEF 560
+AGE+ E+ A +L+ +L+ L+ + +++ L +C+ L+ G+G+ L F
Sbjct: 559 LAGEEEELNASQLQALLSIALEPARAHTSTPREIGLRTCE---QLLQCFGHGQSLALHHF 615
Query: 561 KVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQL 620
+ W L +W +F +FD D SGTM++YELR AL AAGF L++ L Q + RY D L++
Sbjct: 616 QQLWGYLLEWQAIFNKFDEDTSGTMNSYELRLALNAAGFHLNNQLTQTLTSRYRDSRLRV 675
Query: 621 DFDDFLNCLVRL 632
DF+ F++C+ L
Sbjct: 676 DFERFVSCVAHL 687
>gi|223468608 calpain 14 [Homo sapiens]
Length = 684
Score = 435 bits (1118), Expect = e-122
Identities = 255/672 (37%), Positives = 378/672 (56%), Gaps = 53/672 (7%)
Query: 27 QSFEQMRQECLQRGTLFEDADFPASNSSLFYSERPQ-IP--FVWKRPGEIVKNPEFILGG 83
Q FE + ECL+ G LFED FPA+ SS+ Q +P WKRP E+ NP+F
Sbjct: 28 QDFEALLAECLRNGCLFEDTSFPATLSSIGSGSLLQKLPPRLQWKRPPELHSNPQFYFAK 87
Query: 84 ATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEWLD 143
A R D+CQG +GDCW LAA+ +L L+Q L+RV+P +QSF YAGIF F FW + W+
Sbjct: 88 AKRLDLCQGIVGDCWFLAALQALALHQDILSRVVPLNQSFTEKYAGIFRFWFWHYGNWVP 147
Query: 144 VVIDDRLPTFR-DRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGG 202
VVIDDRLP +LVF+ S N FW ALLEKAYAKL+GSYE L+ G EA+ DFTGG
Sbjct: 148 VVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEKAYAKLSGSYEDLQSGQVSEALVDFTGG 207
Query: 203 VAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTGID 262
V T EA N ++IL +A +L+GC E GL++GHAY++TGI
Sbjct: 208 VTMTINLAEAHGNLWDILIEATYNRTLIGC-----QTHSGEKILENGLVEGHAYTLTGIR 262
Query: 263 QVSFRGQRIELIRIRNPWGQVEWNGSWSDR-------------------------MAFKD 297
+V+ + + L+++RNPWG+VEW G WSD M +D
Sbjct: 263 KVTCKHRPEYLVKLRNPWGKVEWKGDWSDSSSKWELLSPKEKILLLRKDNDGEFWMTLQD 322
Query: 298 FKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFL-DTFWTNPQIKL 356
FK HF + IC LTP L ++A KW T+ +G W + STAGG R L DTFW NPQ L
Sbjct: 323 FKTHFVLLVICKLTPGLLSQEAAQKWTYTMREGRWEKRSTAGGQRQLLQDTFWKNPQFLL 382
Query: 357 SLTEKDEGQEE---CSFLVALMQKDRRKLKRFGANVLTIGYAIY---ECPDKDEHLNKDF 410
S+ +EG+ CS LV+L+QK R + ++ +L IG+ +Y + D L +F
Sbjct: 383 SVWRPEEGRRSLRPCSVLVSLLQKPRHRCRK-RKPLLAIGFYLYRMNKYHDDQRRLPPEF 441
Query: 411 FRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEKKAITRDM 470
F+ + ++ F+ +EVS L PG Y+++P E HQ+++F LR+FS +K I ++
Sbjct: 442 FQRNTPLSQPDRFLKEKEVSQELCLEPGTYLIVPCILEAHQKSEFVLRVFS-RKHIFYEI 500
Query: 471 DGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQKKKDI 530
N + + + DQ +++ F FE + E+ A +L+ +LN +
Sbjct: 501 GSNSGVVFSKEIE----DQNERQDEFFTKFFE----KHPEINAVQLQNLLNQMTWSSLGS 552
Query: 531 KFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMSTYEL 590
+ SL +C+ I++L+D + +G + EF+ W +LK +F + D SG ++ +L
Sbjct: 553 RQPFFSLEACQGILALLDLNASGTMSIQEFRDLWKQLKLSQKVFHKQDRG-SGYLNWEQL 611
Query: 591 RTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKNKEFI 650
A++ AG LS + QL+++RY LQ+DF F++ ++R+EN VFQ L T++ + I
Sbjct: 612 HAAMREAGIMLSDDVCQLMLIRYGGPRLQMDFVSFIHLMLRVENMEDVFQNL-TQDGKGI 670
Query: 651 HLNINEFIHLTM 662
+L E++ + +
Sbjct: 671 YLQKPEWMMMAL 682
>gi|37577157 calpain 5 [Homo sapiens]
Length = 640
Score = 316 bits (809), Expect = 5e-86
Identities = 187/513 (36%), Positives = 276/513 (53%), Gaps = 76/513 (14%)
Query: 27 QSFEQMRQECLQRGTLFEDADFPASNSSLFYSERPQIPFVWKRPGEIVKNPEFILGGATR 86
Q++ +R++C +R LFED FPA++ SL+Y P WKRP I ++P + G +
Sbjct: 11 QNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPAVRWKRPKGICEDPRLFVDGISS 70
Query: 87 TDICQGELGDCWLLAAIASLTLNQKALARVIP--QDQSFGP----GYAGIFHFQFWQHSE 140
D+ QG++G+CW +AA +SL + +VIP ++Q + P YAGIFHF FW+ E
Sbjct: 71 HDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIFHFHFWRFGE 130
Query: 141 WLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFT 200
W+DVVIDDRLPT ++L++ HS NEFW AL+EKAYAKL G Y+AL GG+ +A+ DFT
Sbjct: 131 WVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFT 190
Query: 201 GGVAE-------TFQTKEAPEN-FYEILEKALKRGSLLGCFIDTRSAAESEARTPFGLIK 252
GGV+E F E N +E + K RG L+ I +AA+ EAR GL+K
Sbjct: 191 GGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAVTAADMEARLACGLVK 250
Query: 253 GHAYSVTGIDQVS--------FRGQRIELIRIRNPWGQVEWNGSWSDR------------ 292
GHAY+VT + +V F+ +++++IR+RNPWG+ EWNG WSD
Sbjct: 251 GHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQKVSKSER 310
Query: 293 --------------MAFKDFKAHFDKVEICNLTPDALEEDAIHK-WEVTVHQGSWV---- 333
M F+D +F + C + + +IHK WE G+W
Sbjct: 311 EKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVINTS--HLSIHKTWEEARLHGAWTLHED 368
Query: 334 -RGSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEECSFLVALMQKDRRKLKRFG-ANVLT 391
R + GGC N DTF+ NPQ + + ++ L+ + Q+ +R +R G L
Sbjct: 369 PRQNRGGGCINHKDTFFQNPQYIFEVKKPED-----EVLICIQQRPKRSTRREGKGENLA 423
Query: 392 IGYAIYECPDKDEHLNKDFFRYHA--SRARSKTFINLREVSDRFKLPPGEYILIPSTFEP 449
IG+ IY+ + + +R H+ +A S +IN R V R P G Y++IP+TFEP
Sbjct: 424 IGFDIYKVEENRQ------YRMHSLQHKAASSIYINSRSVFLRTDQPEGRYVIIPTTFEP 477
Query: 450 HQEADFCLRIFSEKKAITRDMDGNVDIDLPEPP 482
+F LR+F++ + R ++ L EPP
Sbjct: 478 GHTGEFLLRVFTDVPSNCR------ELRLDEPP 504
>gi|41152101 calpain 13 [Homo sapiens]
Length = 669
Score = 276 bits (706), Expect = 4e-74
Identities = 206/683 (30%), Positives = 330/683 (48%), Gaps = 81/683 (11%)
Query: 27 QSFEQMRQECLQRGTLFEDADFPASNSSL---FYSERPQIPFVWKRPGEIVKNP-EFILG 82
Q F +R CL G F+D FPA++SS+ E+ +WKRP ++ P FIL
Sbjct: 19 QDFTTLRDHCLSMGRTFKDETFPAADSSIGQKLLQEKRLSNVIWKRPQDLPGGPPHFILD 78
Query: 83 GATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEWL 142
+R DI QG DCW LAA+ SLT N + +++ QSF YAGIF F+FWQ +W+
Sbjct: 79 DISRFDIQQGGAADCWFLAALGSLTQNPQYRQKIL-MVQSFSHQYAGIFRFRFWQCGQWV 137
Query: 143 DVVIDDRLPTFRDRLVFLHSADHN-EFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTG 201
+VVIDDRLP D+ +F+ N EFW LLEKAYAKL GSY L G +A+ D TG
Sbjct: 138 EVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSYSDLHYGFLEDALVDLTG 197
Query: 202 GVAETFQTKEAPENFYEILEKALKRGSLLGCF-----IDTRSAAESEARTPFGLIKGHAY 256
GV +P + + ++ A K GSL+ C DT A E+ GL+ HAY
Sbjct: 198 GVITNIHLHSSPVDLVKAVKTATKAGSLITCATPSGPTDTAQAMEN------GLVSLHAY 251
Query: 257 SVTGIDQVSFRGQRIELIRIRNP--WGQVEWNGSWSDR---------------------- 292
+VTG +Q+ +R E+I + NP WG+ EW G WSD
Sbjct: 252 TVTGAEQIQYRRGWEEIISLWNPWGWGEAEWRGRWSDGSQEWEETCDPRKSQLHKKREDG 311
Query: 293 ---MAFKDFKAHFDKVEICNLTPDALEE-DAIHK-WEVTVHQGSWVRGSTAGGCRNFLDT 347
M+ +DF+ F + IC+ P L+ + +H+ W + + + G+TAGG RN
Sbjct: 312 EFWMSCQDFQQKFIAMFICSEIPITLDHGNTLHEGWSQIMFRKQVILGNTAGGPRN---- 367
Query: 348 FWTNPQIKLSLTEKDEGQEECSFLVALMQKDRRKLK----RFGANVLTIGYAIYECPDKD 403
+ Q S+ E EG + + K + V+ G +
Sbjct: 368 ---DAQFNFSVQEPMEGTNVVVCVTVAVTPSNLKAEDAKFPLDFQVILAGSQRFR----- 419
Query: 404 EHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEK 463
E FF + +S R + + L PG Y+++ T + A+F LRIF +
Sbjct: 420 EKFPPVFFSSFRNTVQSSNNKFRRNFTMTYHLSPGNYVVVAQT--RRKSAEFLLRIFLKM 477
Query: 464 KAITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAV 523
R + + ++ + K +P + +++ ++F + A + +++ A +L+ +LN
Sbjct: 478 PDSDRHLSSHFNLRM----KGSPSEHGSQQ-----SIFNRYAQQRLDIDATQLQGLLNQE 528
Query: 524 LQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSG 583
L SL C+++++LM+ NG+L+ +EF W +L + ++F + G
Sbjct: 529 LLTGP--PGDMFSLDECRSLVALMELKVNGRLDQEEFARLWKRLVHYQHVFQKVQT-SPG 585
Query: 584 TMSTYELRTALK----AAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVF 639
+ + +L A++ G +S LL L+ LRY+D ++ F + L+RLE ++ F
Sbjct: 586 VLLSSDLWKAIENTDFLRGIFISRELLHLVTLRYSDSVGRVSFPSLVCFLMRLEAMAKTF 645
Query: 640 QALSTKNKEFIHLNINEFIHLTM 662
+ LS K+ + ++L E++ L M
Sbjct: 646 RNLS-KDGKGLYLTEMEWMSLVM 667
>gi|27765076 calpain 3 isoform d [Homo sapiens]
Length = 309
Score = 270 bits (689), Expect = 4e-72
Identities = 130/302 (43%), Positives = 189/302 (62%), Gaps = 43/302 (14%)
Query: 404 EHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEADFCLRIFSEK 463
+HL KDFF Y+AS+ARSKT+IN+REVS RF+LPP EY+++PST+EPHQE +F LR+FSEK
Sbjct: 6 QHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEK 65
Query: 464 KAITRDMDGNVDIDLPEPPKPTPP------------------------------------ 487
+ ++ +++ + +D P K T P
Sbjct: 66 RNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSP 125
Query: 488 -------DQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFKKLSLISC 540
DQE+EE+Q+FR +F+Q+AG+DME+ A+EL+ VLN V+ K KD+K +L SC
Sbjct: 126 QPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESC 185
Query: 541 KNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQ 600
+++I+LMDT G+GKL EF W+K+K W +F +D D+SGT+++YE+R A+ AGF
Sbjct: 186 RSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFH 245
Query: 601 LSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKNKEFIHLNINEFIHL 660
L++ L +I +RYAD+ + +DFD F+ C VRLE R F A I LN+ E++ L
Sbjct: 246 LNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQL 305
Query: 661 TM 662
TM
Sbjct: 306 TM 307
>gi|13186316 calpain 6 [Homo sapiens]
Length = 641
Score = 258 bits (659), Expect = 1e-68
Identities = 169/511 (33%), Positives = 261/511 (51%), Gaps = 75/511 (14%)
Query: 27 QSFEQMRQECLQRGTLFEDADFPASNSSLFYSERPQIPFVWKRPGEIVKNPEFILGGATR 86
Q +++++QEC++ LF D F N SLFY+ VWKRP +I +P I+G +
Sbjct: 11 QKYQELKQECIKDSRLFCDPTFLPENDSLFYNRLLPGKVVWKRPQDICDDPHLIVGNISN 70
Query: 87 TDICQGELGDCWLLAAIASLTLNQKALARVIP--QDQSFGPG----YAGIFHFQFWQHSE 140
+ QG LG +++A + L + + + IP ++Q + P YAGIFHF+FW E
Sbjct: 71 HQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGIFHFRFWHFGE 130
Query: 141 WLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFT 200
W +VVIDD LPT LVF S NEFW+ALLEKAYAKL G YEAL G + + + DFT
Sbjct: 131 WTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTITDIIVDFT 190
Query: 201 GGVAETFQTK-----EAPENFYEI---LEKALKRGSLLGCFIDTRSAAESEARTPFGLIK 252
G +AET + E E Y++ L K +G L+ C I++ + E E T +GL+K
Sbjct: 191 GTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIESPNQEEQEVETDWGLLK 250
Query: 253 GHAYSVTGIDQVS--------FRGQRIELIRIRNPWGQVEWNGSWS------------DR 292
GH Y++T I ++ F +++ ++R+RNP G+ EW+G WS DR
Sbjct: 251 GHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISEEWQQLTASDR 310
Query: 293 --------------MAFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRG--- 335
M+ +DF +F K+ +C + + + E+ G W
Sbjct: 311 KNLGLVMSDDGEFWMSLEDFCRNFHKLNVCRNVNNPI----FGRKELESVLGCWTVDDDP 366
Query: 336 --STAGGCRNFLDTFWTNPQIKLSLTEKDEGQEECSFLVALMQKDRRKLKRFGA-NVLTI 392
+ +GGC N DTF NPQ ++ E +++L QKD R +R G + I
Sbjct: 367 LMNRSGGCYNNRDTFLQNPQYIFTVPEDGH-----KVIMSLQQKDLRTYRRMGRPDNYII 421
Query: 393 GYAIYECPDKDEHLNKDFFRYHA---SRARSKTFINLREVSDRFKLPPGEYILIPSTFEP 449
G+ +++ +N+ F +H RA + T+I+ R V L G Y+L+P+ F+
Sbjct: 422 GFELFKV-----EMNRKFRLHHLYIQERAGTSTYIDTRTVFLSKYLKKGNYVLVPTMFQH 476
Query: 450 HQEADFCLRIFSEKKAITRDMDGNVDIDLPE 480
+ ++F LRIFSE R++ +D+P+
Sbjct: 477 GRTSEFLLRIFSEVPVQLREL----TLDMPK 503
>gi|13186302 calpain 10 isoform a [Homo sapiens]
Length = 672
Score = 174 bits (442), Expect = 2e-43
Identities = 141/488 (28%), Positives = 214/488 (43%), Gaps = 81/488 (16%)
Query: 42 LFEDADFPASNSSLFYS-ERPQIPF----VWKRPGEIVKNPEFILGGATRTDICQGELGD 96
LF DA FPA++SSLF P F W+RP EI P + QG LGD
Sbjct: 13 LFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGD 72
Query: 97 CWLLAAIASLTLNQKALARVIPQDQSFGPG--YAGIFHFQFWQHSEWLDVVIDDRLPTFR 154
CW L A A+L ++ L +VIP Q Y G F + WQ W++V DDRLP
Sbjct: 73 CWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPCLA 132
Query: 155 DRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAETFQTK---- 210
RL F + FW LLEK YAK++GSYE L G +A+ D TGG+AE + K
Sbjct: 133 GRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKGVAG 192
Query: 211 -----EAPENFYEILEKAL---KRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTGID 262
+ P + + L K L+ C + + A E L + HA+ V+ +
Sbjct: 193 SGGQQDRPGRWEHRTCRQLLHLKDQCLISCCVLSPRAGARE------LGEFHAFIVSDLR 246
Query: 263 QVSFR-GQRIELIRIRNPWGQVEWNGSWSDR-------------------------MAFK 296
++ + GQ I L+RI+NPWG+ W G W + + +
Sbjct: 247 ELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQLQEGEFWVEEE 306
Query: 297 DFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQ----GSWVRGSTAGGCRNFLDTFWTNP 352
+F FD++ + +A +++ + H G+WV+G +AGGCRN F +NP
Sbjct: 307 EFLREFDELTVGYPVTEAGHLQSLYTERLLCHTRALPGAWVKGQSAGGCRN-NSGFPSNP 365
Query: 353 QIKLSLTEKDEGQEECSFLVALMQKDRRKLKRFGANVLTI------GYAIYECPDKD-EH 405
+ L ++E E +A++Q+ R + + ++ P K +
Sbjct: 366 KFWLRVSEPSE------VYIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIPGKHYQA 419
Query: 406 LNKDFFRYHASRARSKTFINL------------REVSDRFKLPPGEYILIPSTFEPHQEA 453
+ ++ R +++ REV R +L PG Y+ +PSTF
Sbjct: 420 VGLHLWKVEKRRVNLPRVLSMPPVAGTACHAYDREVHLRCELSPGYYLAVPSTFLKDAPG 479
Query: 454 DFCLRIFS 461
+F LR+FS
Sbjct: 480 EFLLRVFS 487
Score = 45.4 bits (106), Expect = 2e-04
Identities = 40/138 (28%), Positives = 56/138 (40%), Gaps = 8/138 (5%)
Query: 322 KWEVTVHQGSWVRGSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEECSFLVALMQKDRRK 381
+W +GSW G TAGG RNF ++ TNP S+ EG + L Q R
Sbjct: 513 EWGTVQLRGSWRVGQTAGGSRNFA-SYPTNPCFPFSV---PEGPGPRCVRITLHQHCRPS 568
Query: 382 LKRFGANVLTIGYAIYECPDKDEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYI 441
F IG+ I++ P+ + +EVS LP G Y
Sbjct: 569 DTEFH----PIGFHIFQVPEGGRSQDAPPLLLQEPLLSCVPHRYAQEVSRLCLLPAGTYK 624
Query: 442 LIPSTFEPHQEADFCLRI 459
++PST+ P E F + I
Sbjct: 625 VVPSTYLPDTEGAFTVTI 642
>gi|89353291 calpain 10 isoform c [Homo sapiens]
Length = 517
Score = 167 bits (423), Expect = 3e-41
Identities = 138/488 (28%), Positives = 208/488 (42%), Gaps = 83/488 (17%)
Query: 42 LFEDADFPASNSSLFYS-ERPQIPF----VWKRPGEIVKNPEFILGGATRTDICQGELGD 96
LF DA FPA++SSLF P F W+RP EI P + QG LGD
Sbjct: 13 LFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGD 72
Query: 97 CWLLAAIASLTLNQKALARVIPQDQSFGPG--YAGIFHFQFWQHSEWLDVVIDDRLPTFR 154
CW L A A+L ++ L +VIP Q Y G F + WQ W++V DDRLP
Sbjct: 73 CWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPCLA 132
Query: 155 DRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAETFQTK---- 210
RL F + FW LLEK YAK++GSYE L G +A+ D TGG+AE + K
Sbjct: 133 GRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKGVAG 192
Query: 211 -----EAPENFYEILEKAL---KRGSLLGCFIDTRSAAESEARTPFGLIKGHAYSVTGID 262
+ P + + L K L+ C + + A E L + HA+ V+ +
Sbjct: 193 SGGQQDRPGRWEHRTCRQLLHLKDQCLISCCVLSPRAGARE------LGEFHAFIVSDLR 246
Query: 263 QVSFR-GQRIELIRIRNPWGQVEWNGSWSDR-------------------------MAFK 296
++ + GQ I L+RI+NPWG+ W G W + + +
Sbjct: 247 ELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQLQEGEFWVEEE 306
Query: 297 DFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQ----GSWVRGSTAGGCRNFLDTFWTNP 352
+F FD++ + +A +++ + H G+WV+G +AGGCRN F +NP
Sbjct: 307 EFLREFDELTVGYPVTEAGHLQSLYTERLLCHTRALPGAWVKGQSAGGCRN-NSGFPSNP 365
Query: 353 QIKLSLTEKDEGQEECSFLVALMQKDRRKLKRF---------------------GANVLT 391
+ L ++E E +A++Q+ R + G +
Sbjct: 366 KFWLRVSEPSE------VYIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIPGKHYQA 419
Query: 392 IGYAIYECPDKDEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQ 451
+G +++ P+ + +EVS LP G Y ++PST+ P
Sbjct: 420 VGLHLWKVPEGGRSQDAPPLLLQEPLLSCVPHRYAQEVSRLCLLPAGTYKVVPSTYLPDT 479
Query: 452 EADFCLRI 459
E F + I
Sbjct: 480 EGAFTVTI 487
>gi|14161692 calpain small subunit 2 [Homo sapiens]
Length = 248
Score = 166 bits (419), Expect = 8e-41
Identities = 84/189 (44%), Positives = 126/189 (66%), Gaps = 8/189 (4%)
Query: 482 PKPTPPDQ--------ETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFK 533
P+P P Q E+EE +RFR F Q+AG DMEV A +L +LN VL K KD+K
Sbjct: 58 PEPPPTQQHFTSVEASESEEVRRFRQQFTQLAGPDMEVGATDLMNILNKVLSKHKDLKTD 117
Query: 534 KLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMSTYELRTA 593
SL +C++I+S+MD+ GKL F+EFK W+ +K+W ++ ++D D SG++ + +LR A
Sbjct: 118 GFSLDTCRSIVSVMDSDTTGKLGFEEFKYLWNNIKKWQCVYKQYDRDHSGSLGSSQLRGA 177
Query: 594 LKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKNKEFIHLN 653
L+AAGFQL+ L Q+IV RYA+E+ +DF++F++CLVRL+ R F++L I ++
Sbjct: 178 LQAAGFQLNEQLYQMIVRRYANEDGDMDFNNFISCLVRLDAMFRAFKSLDRDRDGLIQVS 237
Query: 654 INEFIHLTM 662
I E++ LTM
Sbjct: 238 IKEWLQLTM 246
>gi|4502565 calpain, small subunit 1 [Homo sapiens]
Length = 268
Score = 165 bits (417), Expect = 1e-40
Identities = 80/189 (42%), Positives = 124/189 (65%), Gaps = 5/189 (2%)
Query: 479 PEPPKPTP-----PDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFK 533
PEPP P E+EE ++FR LF Q+AG+DMEV+A EL +LN V+ + D+K
Sbjct: 78 PEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTD 137
Query: 534 KLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMSTYELRTA 593
+ +C++++++MD+ GKL F+EFK W+ +K+W ++ +FD D+SGT+ + EL A
Sbjct: 138 GFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGA 197
Query: 594 LKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKNKEFIHLN 653
+AAGF L+ HL +I+ RY+DE +DFD+F++CLVRL+ R F++L I +N
Sbjct: 198 FEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVN 257
Query: 654 INEFIHLTM 662
I E++ LTM
Sbjct: 258 IQEWLQLTM 266
>gi|51599151 calpain, small subunit 1 [Homo sapiens]
Length = 268
Score = 165 bits (417), Expect = 1e-40
Identities = 80/189 (42%), Positives = 124/189 (65%), Gaps = 5/189 (2%)
Query: 479 PEPPKPTP-----PDQETEEEQRFRALFEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFK 533
PEPP P E+EE ++FR LF Q+AG+DMEV+A EL +LN V+ + D+K
Sbjct: 78 PEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTD 137
Query: 534 KLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMSTYELRTA 593
+ +C++++++MD+ GKL F+EFK W+ +K+W ++ +FD D+SGT+ + EL A
Sbjct: 138 GFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGA 197
Query: 594 LKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLENASRVFQALSTKNKEFIHLN 653
+AAGF L+ HL +I+ RY+DE +DFD+F++CLVRL+ R F++L I +N
Sbjct: 198 FEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVN 257
Query: 654 INEFIHLTM 662
I E++ LTM
Sbjct: 258 IQEWLQLTM 266
>gi|27765080 calpain 3 isoform e [Homo sapiens]
Length = 156
Score = 150 bits (380), Expect = 3e-36
Identities = 70/154 (45%), Positives = 102/154 (66%)
Query: 509 MEVTAEELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLK 568
ME+ A+EL+ VLN V+ K KD+K +L SC+++I+LMDT G+GKL EF W+K+K
Sbjct: 1 MEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIK 60
Query: 569 QWINLFLRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNC 628
W +F +D D+SGT+++YE+R A+ AGF L++ L +I +RYAD+ + +DFD F+ C
Sbjct: 61 AWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICC 120
Query: 629 LVRLENASRVFQALSTKNKEFIHLNINEFIHLTM 662
VRLE R F A I LN+ E++ LTM
Sbjct: 121 FVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTM 154
>gi|27765078 calpain 3 isoform e [Homo sapiens]
Length = 156
Score = 150 bits (380), Expect = 3e-36
Identities = 70/154 (45%), Positives = 102/154 (66%)
Query: 509 MEVTAEELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLK 568
ME+ A+EL+ VLN V+ K KD+K +L SC+++I+LMDT G+GKL EF W+K+K
Sbjct: 1 MEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIK 60
Query: 569 QWINLFLRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNC 628
W +F +D D+SGT+++YE+R A+ AGF L++ L +I +RYAD+ + +DFD F+ C
Sbjct: 61 AWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICC 120
Query: 629 LVRLENASRVFQALSTKNKEFIHLNINEFIHLTM 662
VRLE R F A I LN+ E++ LTM
Sbjct: 121 FVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTM 154
>gi|5032105 small optic lobes [Homo sapiens]
Length = 1086
Score = 126 bits (316), Expect = 7e-29
Identities = 122/457 (26%), Positives = 177/457 (38%), Gaps = 84/457 (18%)
Query: 36 CLQRGTLFEDADFPASNSSLFYSERPQIPF---VWKRPGEIV-------KNPEFILGGAT 85
C + F D FP S+ + + W RP EI + +
Sbjct: 481 CRENNVSFVDDSFPPGPESVGFPAGDSVQQRVRQWLRPQEINCSVFRDHRATWSVFHTLR 540
Query: 86 RTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEWLDVV 145
+DI QG LG+CW L+A+A L + RV+ G + + + W V+
Sbjct: 541 PSDILQGLLGNCWFLSALAVLAERPDLVERVMVTRSLCAEG---AYQVRLCKDGTWTTVL 597
Query: 146 IDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAE 205
+DD LP + A + W AL+EKA AKL+GSY AL+ G AIE + TG E
Sbjct: 598 VDDMLPCDEAGCLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRAIEGLATLTGAPCE 657
Query: 206 TF-------QTKEAPENFYEILEKAL---KRGSLLGCFI-DTRSAAESEARTPFGLIKGH 254
+ +E P + I K L + G L+G + A GL H
Sbjct: 658 SLALQLSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVDDSAYESLGLRPRH 717
Query: 255 AYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDR---------------------- 292
AYS+ + V Q L+R+RNPWG+ WNGSWSD
Sbjct: 718 AYSILDVRDV----QGTRLLRLRNPWGRFSWNGSWSDEWPHWPGHLRGELMPHGSSEGVF 773
Query: 293 -MAFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTN 351
M + DF +FD V+IC + D W+ QG + ++A
Sbjct: 774 WMEYGDFVRYFDSVDICKVHSD---------WQEARVQGCFPSSASA------------- 811
Query: 352 PQIKLSLTEKDEGQEECSFLVALMQKDRRKLKRFGANVLTIGYAIYECP-DKDEHLNKDF 410
P +LT E S AL Q+ R+ +++L + ++ HL+
Sbjct: 812 PVGVTALTV----LERASLEFALFQEGSRRSDAVDSHLLDLCILVFRATFGSGGHLSLGR 867
Query: 411 FRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTF 447
H+ RA K VS L PGEY ++ F
Sbjct: 868 LLAHSKRAVKKF------VSCDVMLEPGEYAVVCCAF 898
>gi|38679884 sorcin isoform b [Homo sapiens]
Length = 183
Score = 94.4 bits (233), Expect = 3e-19
Identities = 52/164 (31%), Positives = 89/164 (54%), Gaps = 4/164 (2%)
Query: 501 FEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEF 560
F VAG+D ++ A+EL+ L Q +K +L +C+ ++S++D +G + F+EF
Sbjct: 24 FAAVAGQDGQIDADELQRCLT---QSGIAGGYKPFNLETCRLMVSMLDRDMSGTMGFNEF 80
Query: 561 KVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQL 620
K W L W F+ FD D+SGT+ EL+ AL GF+LS + I RY+ ++
Sbjct: 81 KELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRLSPQAVNSIAKRYSTNG-KI 139
Query: 621 DFDDFLNCLVRLENASRVFQALSTKNKEFIHLNINEFIHLTMNI 664
FDD++ C V+L + F+ T + ++ ++FI M++
Sbjct: 140 TFDDYIACCVKLRALTDSFRRRDTAQQGVVNFPYDDFIQCVMSV 183
>gi|4507207 sorcin isoform a [Homo sapiens]
Length = 198
Score = 94.4 bits (233), Expect = 3e-19
Identities = 52/164 (31%), Positives = 89/164 (54%), Gaps = 4/164 (2%)
Query: 501 FEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEF 560
F VAG+D ++ A+EL+ L Q +K +L +C+ ++S++D +G + F+EF
Sbjct: 39 FAAVAGQDGQIDADELQRCLT---QSGIAGGYKPFNLETCRLMVSMLDRDMSGTMGFNEF 95
Query: 561 KVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQL 620
K W L W F+ FD D+SGT+ EL+ AL GF+LS + I RY+ ++
Sbjct: 96 KELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTTMGFRLSPQAVNSIAKRYSTNG-KI 154
Query: 621 DFDDFLNCLVRLENASRVFQALSTKNKEFIHLNINEFIHLTMNI 664
FDD++ C V+L + F+ T + ++ ++FI M++
Sbjct: 155 TFDDYIACCVKLRALTDSFRRRDTAQQGVVNFPYDDFIQCVMSV 198
>gi|6912388 grancalcin, EF-hand calcium binding protein [Homo
sapiens]
Length = 217
Score = 89.0 bits (219), Expect = 1e-17
Identities = 55/164 (33%), Positives = 87/164 (53%), Gaps = 4/164 (2%)
Query: 501 FEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEF 560
F VAG+D EV AEEL+ L Q + + SL +C+ +I+++D GK+ F+ F
Sbjct: 58 FSAVAGQDGEVDAEELQRCLT---QSGINGTYSPFSLETCRIMIAMLDRDHTGKMGFNAF 114
Query: 561 KVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQL 620
K W L W F+ D D SGT+ +ELR A+ G++LS L IV RY+ + ++
Sbjct: 115 KELWAALNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLSPQTLTTIVKRYS-KNGRI 173
Query: 621 DFDDFLNCLVRLENASRVFQALSTKNKEFIHLNINEFIHLTMNI 664
FDD++ C V+L + F+ + + ++F+ TM I
Sbjct: 174 FFDDYVACCVKLRALTDFFRKRDHLQQGSANFIYDDFLQGTMAI 217
>gi|7656959 calpain 7 [Homo sapiens]
Length = 813
Score = 82.4 bits (202), Expect = 1e-15
Identities = 68/240 (28%), Positives = 113/240 (47%), Gaps = 24/240 (10%)
Query: 67 WKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAIA-----SLTLNQKALARVI-PQD 120
W RP ++ NP I + I Q + DC +A++A N+K + +I PQ+
Sbjct: 261 WVRPEDLTNNPTMIYT-VSSFSIKQTIVSDCSFVASLAISAAYERRFNKKLITGIIYPQN 319
Query: 121 QSFGPGYAGIFHFQFWQHSEWLD--VVIDDRLPT-FRDRLVFLHSADHNEFWSALLEKAY 177
+ P Y + H + V+IDD+LP + L+ +S + +E W +L+EKAY
Sbjct: 320 KDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPVDHKGELLCSYSNNKSELWVSLIEKAY 379
Query: 178 AKLNGSYEALKGGSAIEAMEDFTGGVAETF------QTKEAPENFYEILEKALKRGSLLG 231
K+ G Y+ S I+ + TG + E QT +F + ++ K L+
Sbjct: 380 MKVMGGYDFPGSNSNID-LHALTGWIPERIAMHSDSQTFSKDNSFRMLYQRFHKGDVLIT 438
Query: 232 CFIDTRSAAESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSD 291
+ AE E +GL+ HAY+V +D F+G R I+++NPW + W G +S+
Sbjct: 439 ASTGMMTEAEGE---KWGLVPTHAYAV--LDIREFKGLR--FIQLKNPWSHLRWKGRYSE 491
>gi|6912582 penta-EF-hand domain containing 1 [Homo sapiens]
Length = 284
Score = 73.6 bits (179), Expect = 6e-13
Identities = 37/125 (29%), Positives = 67/125 (53%), Gaps = 2/125 (1%)
Query: 539 SCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLFLRFDADKSGTMSTYELRTALKAAG 598
+C +I++ D + +G+++ F W ++QW NLF ++D D+SG++S EL+ AL G
Sbjct: 155 TCLMMINMFDKTKSGRIDVYGFSALWKFIQQWKNLFQQYDRDRSGSISYTELQQALSQMG 214
Query: 599 FQLSSHLLQLIVLRYADEELQ--LDFDDFLNCLVRLENASRVFQALSTKNKEFIHLNINE 656
+ LS QL+V RY + D F+ +L+ + F+ T + I L+ +
Sbjct: 215 YNLSPQFTQLLVSRYCPRSANPAMQLDRFIQVCTQLQVLTEAFREKDTAVQGNIRLSFED 274
Query: 657 FIHLT 661
F+ +T
Sbjct: 275 FVTMT 279
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.417
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,610,279
Number of Sequences: 37866
Number of extensions: 1249532
Number of successful extensions: 4224
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 44
Number of HSP's successfully gapped in prelim test: 34
Number of HSP's that attempted gapping in prelim test: 4001
Number of HSP's gapped (non-prelim): 128
length of query: 664
length of database: 18,247,518
effective HSP length: 109
effective length of query: 555
effective length of database: 14,120,124
effective search space: 7836668820
effective search space used: 7836668820
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.