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Search of human proteins with 7662088
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12
[Homo sapiens]
(1544 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo... 3070 0.0
gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof... 695 0.0
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo... 660 0.0
gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [... 525 e-148
gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [... 525 e-148
gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [... 483 e-136
gi|195972857 Rho/Rac guanine nucleotide exchange factor 18 isofo... 183 1e-45
gi|41327769 Rho/Rac guanine nucleotide exchange factor 18 isofor... 183 1e-45
gi|253735778 Rho/Rac guanine nucleotide exchange factor 2 isofor... 171 5e-42
gi|15011974 Rho/Rac guanine nucleotide exchange factor 2 isoofor... 171 5e-42
gi|253735775 Rho/Rac guanine nucleotide exchange factor 2 isofor... 171 7e-42
gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens] 169 2e-41
gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens] 169 2e-41
gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens] 169 2e-41
gi|122937434 Rho-guanine nucleotide exchange factor [Homo sapiens] 167 6e-41
gi|38373682 pleckstrin homology domain containing family G membe... 145 2e-34
gi|111154084 pleckstrin homology domain containing family G memb... 145 2e-34
gi|111154088 pleckstrin homology domain containing family G memb... 145 2e-34
gi|111154080 pleckstrin homology domain containing family G memb... 145 2e-34
gi|111154078 pleckstrin homology domain containing family G memb... 145 2e-34
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 127 1e-28
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 127 1e-28
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 119 2e-26
gi|114145479 neuroepithelial cell transforming gene 1 isoform 1 ... 89 4e-17
gi|19923327 neuroepithelial cell transforming gene 1 isoform 2 [... 89 4e-17
gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2 ... 88 6e-17
gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1 ... 88 6e-17
gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [H... 88 6e-17
gi|222080070 pleckstrin homology domain-containing family G memb... 86 4e-16
gi|222080068 pleckstrin homology domain-containing family G memb... 86 4e-16
>gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo
sapiens]
Length = 1544
Score = 3070 bits (7960), Expect = 0.0
Identities = 1544/1544 (100%), Positives = 1544/1544 (100%)
Query: 1 MSGTQSTITDRFPLKKPIRHGSILNRESPTDKKQKVERIASHDFDPTDSSSKKTKSSSEE 60
MSGTQSTITDRFPLKKPIRHGSILNRESPTDKKQKVERIASHDFDPTDSSSKKTKSSSEE
Sbjct: 1 MSGTQSTITDRFPLKKPIRHGSILNRESPTDKKQKVERIASHDFDPTDSSSKKTKSSSEE 60
Query: 61 SRSEIYGLVQRCVIIQKDDNGFGLTVSGDNPVFVQSVKEDGAAMRAGVQTGDRIIKVNGT 120
SRSEIYGLVQRCVIIQKDDNGFGLTVSGDNPVFVQSVKEDGAAMRAGVQTGDRIIKVNGT
Sbjct: 61 SRSEIYGLVQRCVIIQKDDNGFGLTVSGDNPVFVQSVKEDGAAMRAGVQTGDRIIKVNGT 120
Query: 121 LVTHSNHLEVVKLIKSGSYVALTVQGRPPGSPQIPLADSEVEPSVIGHMSPIMTSPHSPG 180
LVTHSNHLEVVKLIKSGSYVALTVQGRPPGSPQIPLADSEVEPSVIGHMSPIMTSPHSPG
Sbjct: 121 LVTHSNHLEVVKLIKSGSYVALTVQGRPPGSPQIPLADSEVEPSVIGHMSPIMTSPHSPG 180
Query: 181 ASGNMERITSPVLMGEENNVVHNQKVEILRKMLQKEQERLQLLQEDYNRTPAQRLLKEIQ 240
ASGNMERITSPVLMGEENNVVHNQKVEILRKMLQKEQERLQLLQEDYNRTPAQRLLKEIQ
Sbjct: 181 ASGNMERITSPVLMGEENNVVHNQKVEILRKMLQKEQERLQLLQEDYNRTPAQRLLKEIQ 240
Query: 241 EAKKHIPQLQEQLSKATGSAQDGAVVTPSRPLGDTLTVSEAETDPGDVLGRTDCSSGDAS 300
EAKKHIPQLQEQLSKATGSAQDGAVVTPSRPLGDTLTVSEAETDPGDVLGRTDCSSGDAS
Sbjct: 241 EAKKHIPQLQEQLSKATGSAQDGAVVTPSRPLGDTLTVSEAETDPGDVLGRTDCSSGDAS 300
Query: 301 RPSSDNADSPKSGPKERIYLEENPEKSETIQDTDTQSLVGSPSTRIAPHIIGAEDDDFGT 360
RPSSDNADSPKSGPKERIYLEENPEKSETIQDTDTQSLVGSPSTRIAPHIIGAEDDDFGT
Sbjct: 301 RPSSDNADSPKSGPKERIYLEENPEKSETIQDTDTQSLVGSPSTRIAPHIIGAEDDDFGT 360
Query: 361 EHEQINGQCSCFQSIELLKSRPAHLAVFLHHVVSQFDPATLLCYLYSDLYKHTNSKETRR 420
EHEQINGQCSCFQSIELLKSRPAHLAVFLHHVVSQFDPATLLCYLYSDLYKHTNSKETRR
Sbjct: 361 EHEQINGQCSCFQSIELLKSRPAHLAVFLHHVVSQFDPATLLCYLYSDLYKHTNSKETRR 420
Query: 421 IFLEFHQFFLDRSAHLKVSVPDEMSADLEKRRPELIPEDLHRHYIQTMQERVHPEVQRHL 480
IFLEFHQFFLDRSAHLKVSVPDEMSADLEKRRPELIPEDLHRHYIQTMQERVHPEVQRHL
Sbjct: 421 IFLEFHQFFLDRSAHLKVSVPDEMSADLEKRRPELIPEDLHRHYIQTMQERVHPEVQRHL 480
Query: 481 EDFRQKRSMGLTLAESELTKLDAERDKDRLTLEKERTCAEQIVAKIEEVLMTAQAVEEDK 540
EDFRQKRSMGLTLAESELTKLDAERDKDRLTLEKERTCAEQIVAKIEEVLMTAQAVEEDK
Sbjct: 481 EDFRQKRSMGLTLAESELTKLDAERDKDRLTLEKERTCAEQIVAKIEEVLMTAQAVEEDK 540
Query: 541 SSTMQYVILMYMKHLGVKVKEPRNLEHKRGRIGFLPKIKQSMKKDKEGEEKGKRRGFPSI 600
SSTMQYVILMYMKHLGVKVKEPRNLEHKRGRIGFLPKIKQSMKKDKEGEEKGKRRGFPSI
Sbjct: 541 SSTMQYVILMYMKHLGVKVKEPRNLEHKRGRIGFLPKIKQSMKKDKEGEEKGKRRGFPSI 600
Query: 601 LGPPRRPSRHDNSAIGRAMELQKARHPKHLSTPSSVSPEPQDSAKLRQSGLANEGTDAGY 660
LGPPRRPSRHDNSAIGRAMELQKARHPKHLSTPSSVSPEPQDSAKLRQSGLANEGTDAGY
Sbjct: 601 LGPPRRPSRHDNSAIGRAMELQKARHPKHLSTPSSVSPEPQDSAKLRQSGLANEGTDAGY 660
Query: 661 LPANSMSSVASGASFSQEGGKENDTGSKQVGETSAPGDTLDGTPRTLNTVFDFPPPPLDQ 720
LPANSMSSVASGASFSQEGGKENDTGSKQVGETSAPGDTLDGTPRTLNTVFDFPPPPLDQ
Sbjct: 661 LPANSMSSVASGASFSQEGGKENDTGSKQVGETSAPGDTLDGTPRTLNTVFDFPPPPLDQ 720
Query: 721 VQEEECEVERVTEHGTPKPFRKFDSVAFGESQSEDEQFENDLETDPPNWQQLVSREVLLG 780
VQEEECEVERVTEHGTPKPFRKFDSVAFGESQSEDEQFENDLETDPPNWQQLVSREVLLG
Sbjct: 721 VQEEECEVERVTEHGTPKPFRKFDSVAFGESQSEDEQFENDLETDPPNWQQLVSREVLLG 780
Query: 781 LKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSELRKIFSNLEDILQ 840
LKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSELRKIFSNLEDILQ
Sbjct: 781 LKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSELRKIFSNLEDILQ 840
Query: 841 LHIGLNEQMKAVRKRNETSVIDQIGEDLLTWFSGPGEEKLKHAAATFCSNQPFALEMIKS 900
LHIGLNEQMKAVRKRNETSVIDQIGEDLLTWFSGPGEEKLKHAAATFCSNQPFALEMIKS
Sbjct: 841 LHIGLNEQMKAVRKRNETSVIDQIGEDLLTWFSGPGEEKLKHAAATFCSNQPFALEMIKS 900
Query: 901 RQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPTEREKV 960
RQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPTEREKV
Sbjct: 901 RQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPTEREKV 960
Query: 961 KKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSSLKLSEYPNVEELRNLDLTKRKM 1020
KKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSSLKLSEYPNVEELRNLDLTKRKM
Sbjct: 961 KKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSSLKLSEYPNVEELRNLDLTKRKM 1020
Query: 1021 IHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDDRLVLRCHSKILASTADSKHTFSPVI 1080
IHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDDRLVLRCHSKILASTADSKHTFSPVI
Sbjct: 1021 IHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDDRLVLRCHSKILASTADSKHTFSPVI 1080
Query: 1081 KLSTVLVRQVATDNKALFVISMSDNGAQIYELVAQTVSEKTVWQDLICRMAASVKEQSTK 1140
KLSTVLVRQVATDNKALFVISMSDNGAQIYELVAQTVSEKTVWQDLICRMAASVKEQSTK
Sbjct: 1081 KLSTVLVRQVATDNKALFVISMSDNGAQIYELVAQTVSEKTVWQDLICRMAASVKEQSTK 1140
Query: 1141 PIPLPQSTPGEGDNDEEDPSKLKEEQHGISVTGLQSPDRDLGLESTLISSKPQSHSLSTS 1200
PIPLPQSTPGEGDNDEEDPSKLKEEQHGISVTGLQSPDRDLGLESTLISSKPQSHSLSTS
Sbjct: 1141 PIPLPQSTPGEGDNDEEDPSKLKEEQHGISVTGLQSPDRDLGLESTLISSKPQSHSLSTS 1200
Query: 1201 GKSEVRDLFVAERQFAKEQHTDGTLKEVGEDYQIAIPDSHLPVSEERWALDALRNLGLLK 1260
GKSEVRDLFVAERQFAKEQHTDGTLKEVGEDYQIAIPDSHLPVSEERWALDALRNLGLLK
Sbjct: 1201 GKSEVRDLFVAERQFAKEQHTDGTLKEVGEDYQIAIPDSHLPVSEERWALDALRNLGLLK 1260
Query: 1261 QLLVQQLGLTEKSVQEDWQHFPRYRTASQGPQTDSVIQNSENIKAYHSGEGHMPFRTGTG 1320
QLLVQQLGLTEKSVQEDWQHFPRYRTASQGPQTDSVIQNSENIKAYHSGEGHMPFRTGTG
Sbjct: 1261 QLLVQQLGLTEKSVQEDWQHFPRYRTASQGPQTDSVIQNSENIKAYHSGEGHMPFRTGTG 1320
Query: 1321 DIATCYSPRTSTESFAPRDSVGLAPQDSQASNILVMDHMIMTPEMPTMEPEGGLDDSGEH 1380
DIATCYSPRTSTESFAPRDSVGLAPQDSQASNILVMDHMIMTPEMPTMEPEGGLDDSGEH
Sbjct: 1321 DIATCYSPRTSTESFAPRDSVGLAPQDSQASNILVMDHMIMTPEMPTMEPEGGLDDSGEH 1380
Query: 1381 FFDAREAHSDENPSEGDGAVNKEEKDVNLRISGNYLILDGYDPVQESSTDEEVASSLTLQ 1440
FFDAREAHSDENPSEGDGAVNKEEKDVNLRISGNYLILDGYDPVQESSTDEEVASSLTLQ
Sbjct: 1381 FFDAREAHSDENPSEGDGAVNKEEKDVNLRISGNYLILDGYDPVQESSTDEEVASSLTLQ 1440
Query: 1441 PMTGIPAVESTHQQQHSPQNTHSDGAISPFTPEFLVQQRWGAMEYSCFEIQSPSSCADSQ 1500
PMTGIPAVESTHQQQHSPQNTHSDGAISPFTPEFLVQQRWGAMEYSCFEIQSPSSCADSQ
Sbjct: 1441 PMTGIPAVESTHQQQHSPQNTHSDGAISPFTPEFLVQQRWGAMEYSCFEIQSPSSCADSQ 1500
Query: 1501 SQIMEYIHKIEADLEHLKKVEESYTILCQRLAGSALTDKHSDKS 1544
SQIMEYIHKIEADLEHLKKVEESYTILCQRLAGSALTDKHSDKS
Sbjct: 1501 SQIMEYIHKIEADLEHLKKVEESYTILCQRLAGSALTDKHSDKS 1544
>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform 2
[Homo sapiens]
Length = 1562
Score = 695 bits (1793), Expect = 0.0
Identities = 450/1184 (38%), Positives = 661/1184 (55%), Gaps = 89/1184 (7%)
Query: 34 QKVERIASHDFDPTDSSSKKTKSSSEE--SRSEIYGLVQRCVIIQKDDNGFGLTVSGDNP 91
Q ++R++S + +K+ S + SE GLVQRCVIIQKD +GFG TVSGD
Sbjct: 7 QSIDRLSSLSSLGDSAPERKSPSHHRQPSDASETTGLVQRCVIIQKDQHGFGFTVSGDRI 66
Query: 92 VFVQSVKEDGAAMRAGVQTGDRIIKVNGTLVTHSNHLEVVKLIKSGSYVALTVQGRPPGS 151
V VQSV+ GAAM+AGV+ GDRIIKVNGT+VT+S+HLEVVKLIKSG+YVALT+ G P S
Sbjct: 67 VLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNSSHLEVVKLIKSGAYVALTLLGSSPSS 126
Query: 152 PQIPLADSEVEPSVIGHMSPIMTSPHSPGASGNMERITSPVLMGEENNVVHNQKVEILRK 211
I + P+ ++ ++ SP P +RIT P + + V +ILR
Sbjct: 127 MGISGLQQDPSPAGAPRITSVIPSPPPPPPLPPPQRITGPKPLQDPE--VQKHATQILRN 184
Query: 212 MLQKEQERLQLLQEDYNRTPAQRLLKEIQEAKKHIPQLQEQLSKATGSAQDGAVV---TP 268
ML++E++ LQ + E Y+R PA L ++I+ A++ + QLQ ++ + TG + D + T
Sbjct: 185 MLRQEEKELQRICEVYSRNPASLLEEQIEGARRRVTQLQLKIQQETGGSVDILPLYGDTS 244
Query: 269 SRPLGDTLTVSEAETDPGDVLGRTDCSSGDASRPSSDNA------DSPKSGP--KERIYL 320
RP L++ E D G G S S + ++ DSP++ P R+
Sbjct: 245 QRPSEGRLSLDSQEGDSGLDSGTERFPSLSESLMNRNSVLSDPGLDSPRTSPVIMARVAQ 304
Query: 321 EENPEKSET-IQDTDTQSLVGSPSTRIAPHIIGAEDDD----FGTEHEQINGQCSCFQSI 375
+ S+ + T Q + SP P IIG E+D F E + I FQ +
Sbjct: 305 HHRRQGSDAAVPSTGDQGVDQSPK----PLIIGPEEDYDPGYFNNESDII------FQDL 354
Query: 376 ELLKSRPAHLAVFLHHVVSQFDPATLLCYLYSDLYKHTNSKETRRIFLEFHQFFLDRSAH 435
E LKSRPAHL VFL ++ SQ DP+ LL YL +++Y+ + K++R + + FL+++A
Sbjct: 355 EKLKSRPAHLGVFLRYIFSQADPSPLLFYLCAEVYQQASPKDSRSLGKDIWNIFLEKNAP 414
Query: 436 LKVSVPDEMSADLEKRRPELIPEDLHRHYIQTMQERVHPEVQRHLEDFRQKRSMGLTLAE 495
L+V +P+ + A+++ R L + R + QE PE+Q + D+R KR++GL
Sbjct: 415 LRVKIPEMLQAEIDSR---LRNSEDARGVLCEAQEAAMPEIQEQIHDYRTKRTLGLGSLY 471
Query: 496 SELTKLDAERDKDRLTLEKERTCAEQIVAKIEEVLMTAQAVEEDKSSTMQYVILMYMKHL 555
E LD + D R ER AE+ +A + ++L EED+S+ M + + YM H
Sbjct: 472 GENDLLDLDGDPLR-----ERQVAEKQLAALGDIL---SKYEEDRSAPMDFALNTYMSHA 523
Query: 556 GVKVKEPR---------NLEHKRGRIGFLPKIKQSM--KKDKEGEEKGKRRGFPSILGPP 604
G++++E R + K + F PK K+S KK+K+ E KR +G P
Sbjct: 524 GIRLREARPSNTAEKAQSAPDKDKWLPFFPKTKKSSNSKKEKDALEDKKRNPILKYIGKP 583
Query: 605 RRPSRHDNSAIGRAMELQKARHPKHLSTPSSVSPEPQDSAKLRQSGLANEGTD---AGYL 661
+ S+ +E++ P +V Q +Q GT G
Sbjct: 584 KSSSQSTFHIPLSPVEVK----------PGNVRNIIQHFENNQQYDAPEPGTQRLSTGSF 633
Query: 662 PAN------SMSSVASGASFSQEGGKENDTGSKQVGETSAPGDTLDGTPRTLNTVFDFPP 715
P + S S + G S S +G +E K + D +
Sbjct: 634 PEDLLESDSSRSEIRLGRSESLKGREEMKRSRKAENVPRSRSDVDMDAAAEATRLHQSAS 693
Query: 716 PPLDQVQEEECEVERVTEHGTPKPFRKF---DSVAFGESQSEDEQFENDL--------ET 764
+ +E T TPK R+ S+ F E+DL E
Sbjct: 694 SSTSSLSTRS--LENPTPPFTPKMGRRSIESPSLGFCTDTLLPHLLEDDLGQLSDLEPEP 751
Query: 765 DPPNWQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILS 824
D NWQ V ++V+ GL EI RQEVINELF TE +H+RTL+VLD +FYQR+ +E ++
Sbjct: 752 DAQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMP 811
Query: 825 PSELRKIFSNLEDILQLHIGLNEQMKAVRKRNETSVIDQIGEDLLTWFSGPGEEKLKHAA 884
EL ++F NL +++++H E MK +R+ E +I +I + +L F GP E+L+ A
Sbjct: 812 REELARLFPNLPELIEIHNSWCEAMKKLRE--EGPIIKEISDLMLARFDGPAREELQQVA 869
Query: 885 ATFCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLL 944
A FCS Q ALE+IK++Q+K+SRFQ F+Q+AES+P CRRLQL+D+I ++MQRLTKYPLLL
Sbjct: 870 AQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLL 929
Query: 945 DNIAKYTEWPT-EREKVKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSSLKLSE 1003
++I K+TE T E EK+ +A D CR+IL YVN+AVK+ EN+ RLE YQ+RLD ++L+ +
Sbjct: 930 ESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERAS 989
Query: 1004 YPNVEELRNLDLTKRKMIHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDDRLVLRCHS 1063
P E ++LDLT RKMIHEGPL W++++DKT+DL+ LLLED+LVLLQKQD++L+L+CHS
Sbjct: 990 NPLAAEFKSLDLTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHS 1049
Query: 1064 KILASTADSKHTFSPVIKLSTVLVRQVATDNKALFVISMSDNG-AQIYELVAQTVSEKTV 1122
K ++DSK TFSPV+KL+ VL+R VATD +A F+I S G QIYELVA T S+K
Sbjct: 1050 KTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFIICTSKLGPPQIYELVALTSSDKNT 1109
Query: 1123 WQDLICR-MAASVKEQSTKPIPLPQSTPGEGDNDEEDPSKLKEE 1165
W +L+ + + + P+P+ PG + ++ P+ + E
Sbjct: 1110 WMELLEEAVRNATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVE 1153
>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform 1
[Homo sapiens]
Length = 1522
Score = 660 bits (1702), Expect = 0.0
Identities = 439/1179 (37%), Positives = 642/1179 (54%), Gaps = 119/1179 (10%)
Query: 34 QKVERIASHDFDPTDSSSKKTKSSSEE--SRSEIYGLVQRCVIIQKDDNGFGLTVSGDNP 91
Q ++R++S + +K+ S + SE GLVQRCVIIQKD +GFG TVSGD
Sbjct: 7 QSIDRLSSLSSLGDSAPERKSPSHHRQPSDASETTGLVQRCVIIQKDQHGFGFTVSGDRI 66
Query: 92 VFVQSVKEDGAAMRAGVQTGDRIIKVNGTLVTHSNHLEVVKLIKSGSYVALTVQGRPPGS 151
V VQSV+ GAAM+AGV+ GDRIIKVNGT+VT+S+HLEVVKLIKSG+YVALT+ G P S
Sbjct: 67 VLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNSSHLEVVKLIKSGAYVALTLLGSSPSS 126
Query: 152 PQIPLADSEVEPSVIGHMSPIMTSPHSPGASGNMERITSPVLMGEENNVVHNQKVEILRK 211
I + P+ ++ ++ SP P +RIT P + + V +ILR
Sbjct: 127 MGISGLQQDPSPAGAPRITSVIPSPPPPPPLPPPQRITGPKPLQDPE--VQKHATQILRN 184
Query: 212 MLQKEQERLQ---LLQEDYNRTPAQ-RLLKEIQEAKKHIPQLQEQLSKATGSAQDGAVVT 267
ML++E++ LQ L D ++ P++ RL + QE + E+ + S + V
Sbjct: 185 MLRQEEKELQDILPLYGDTSQRPSEGRLSLDSQEGDSGLDSGTERFPSLSESLMNRNSVL 244
Query: 268 PSRPLGDTLTVSEAETDPGDVLGRTDCSSGDASRPSSDNADSPKSGP--KERIYLEENPE 325
+DPG DSP++ P R+ +
Sbjct: 245 ---------------SDPG--------------------LDSPRTSPVIMARVAQHHRRQ 269
Query: 326 KSET-IQDTDTQSLVGSPSTRIAPHIIGAEDDD----FGTEHEQINGQCSCFQSIELLKS 380
S+ + T Q + SP P IIG E+D F E + I FQ +E LKS
Sbjct: 270 GSDAAVPSTGDQGVDQSPK----PLIIGPEEDYDPGYFNNESDII------FQDLEKLKS 319
Query: 381 RPAHLAVFLHHVVSQFDPATLLCYLYSDLYKHTNSKETRRIFLEFHQFFLDRSAHLKVSV 440
RPAHL VFL ++ SQ DP+ LL YL +++Y+ + K++R + + FL+++A L+V +
Sbjct: 320 RPAHLGVFLRYIFSQADPSPLLFYLCAEVYQQASPKDSRSLGKDIWNIFLEKNAPLRVKI 379
Query: 441 PDEMSADLEKRRPELIPEDLHRHYIQTMQERVHPEVQRHLEDFRQKRSMGLTLAESELTK 500
P+ + A+++ R L + R + QE PE+Q + D+R KR++GL E
Sbjct: 380 PEMLQAEIDSR---LRNSEDARGVLCEAQEAAMPEIQEQIHDYRTKRTLGLGSLYGENDL 436
Query: 501 LDAERDKDRLTLEKERTCAEQIVAKIEEVLMTAQAVEEDKSSTMQYVILMYMKHLGVKVK 560
LD + D R ER AE+ +A + ++L EED+S+ M + + YM H G++++
Sbjct: 437 LDLDGDPLR-----ERQVAEKQLAALGDIL---SKYEEDRSAPMDFALNTYMSHAGIRLR 488
Query: 561 EPR---------NLEHKRGRIGFLPKIKQSM--KKDKEGEEKGKRRGFPSILGPPRRPSR 609
E R + K + F PK K+S KK+K+ E KR +G P+ S+
Sbjct: 489 EARPSNTAEKAQSAPDKDKWLPFFPKTKKSSNSKKEKDALEDKKRNPILKYIGKPKSSSQ 548
Query: 610 HDNSAIGRAMELQKARHPKHLSTPSSVSPEPQDSAKLRQSGLANEGTD---AGYLPAN-- 664
+E++ P +V Q +Q GT G P +
Sbjct: 549 STFHIPLSPVEVK----------PGNVRNIIQHFENNQQYDAPEPGTQRLSTGSFPEDLL 598
Query: 665 ----SMSSVASGASFSQEGGKENDTGSKQVGETSAPGDTLDGTPRTLNTVFDFPPPPLDQ 720
S S + G S S +G +E K + D +
Sbjct: 599 ESDSSRSEIRLGRSESLKGREEMKRSRKAENVPRSRSDVDMDAAAEATRLHQSASSSTSS 658
Query: 721 VQEEECEVERVTEHGTPKPFRKF---DSVAFGESQSEDEQFENDL--------ETDPPNW 769
+ +E T TPK R+ S+ F E+DL E D NW
Sbjct: 659 LSTRS--LENPTPPFTPKMGRRSIESPSLGFCTDTLLPHLLEDDLGQLSDLEPEPDAQNW 716
Query: 770 QQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSELR 829
Q V ++V+ GL EI RQEVINELF TE +H+RTL+VLD +FYQR+ +E ++ EL
Sbjct: 717 QHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELA 776
Query: 830 KIFSNLEDILQLHIGLNEQMKAVRKRNETSVIDQIGEDLLTWFSGPGEEKLKHAAATFCS 889
++F NL +++++H E MK +R+ E +I +I + +L F GP E+L+ AA FCS
Sbjct: 777 RLFPNLPELIEIHNSWCEAMKKLRE--EGPIIKEISDLMLARFDGPAREELQQVAAQFCS 834
Query: 890 NQPFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIAK 949
Q ALE+IK++Q+K+SRFQ F+Q+AES+P CRRLQL+D+I ++MQRLTKYPLLL++I K
Sbjct: 835 YQSIALELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIK 894
Query: 950 YTEWPT-EREKVKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSSLKLSEYPNVE 1008
+TE T E EK+ +A D CR+IL YVN+AVK+ EN+ RLE YQ+RLD ++L+ + P
Sbjct: 895 HTEGGTSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAA 954
Query: 1009 ELRNLDLTKRKMIHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDDRLVLRCHSKILAS 1068
E ++LDLT RKMIHEGPL W++++DKT+DL+ LLLED+LVLLQKQD++L+L+CHSK
Sbjct: 955 EFKSLDLTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVG 1014
Query: 1069 TADSKHTFSPVIKLSTVLVRQVATDNKALFVISMSDNG-AQIYELVAQTVSEKTVWQDLI 1127
++DSK TFSPV+KL+ VL+R VATD +A F+I S G QIYELVA T S+K W +L+
Sbjct: 1015 SSDSKQTFSPVLKLNAVLIRSVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELL 1074
Query: 1128 CR-MAASVKEQSTKPIPLPQSTPGEGDNDEEDPSKLKEE 1165
+ + + P+P+ PG + ++ P+ + E
Sbjct: 1075 EEAVRNATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVE 1113
>gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [Homo
sapiens]
Length = 927
Score = 525 bits (1352), Expect = e-148
Identities = 327/814 (40%), Positives = 481/814 (59%), Gaps = 71/814 (8%)
Query: 350 IIGAEDDDFGTEHE-QINGQCSCFQSIELLKSRPAHLAVFLHHVVSQFDPATLLCYLYSD 408
IIGAED+DF E E Q S FQS+E +K RPAHL L HV QF+P LLC L++D
Sbjct: 38 IIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLMALLQHVALQFEPGPLLCCLHAD 97
Query: 409 LYKHTNSKETRRIFLEFHQFFLDRSAHLKVSVPDEMSADLEKRRPELIPEDLHRHYIQTM 468
+ KE ++ FL+F+ FL+++A L+V VP ++ +L++ R +LI ED+ R ++Q +
Sbjct: 98 MLGSLGPKEAKKAFLDFYHSFLEKTAVLRVPVPPNVAFELDRTRADLISEDVQRRFVQEV 157
Query: 469 QERVHPEVQRHLEDFRQKRSMGLTLAESELTKLDAERDKDRLTLE-KERTCAEQIVAKIE 527
+ V R LEDFR KR MG+T E EL +L+A +DR + E +ER AE+++ +E
Sbjct: 158 VQSQQVAVGRQLEDFRSKRLMGMTPWEQELAQLEAWVGRDRASYEARERHVAERLLMHLE 217
Query: 528 EVLMTAQAVEEDKSSTMQYVILMYMKHLGVKVKEPRNLEHKRGRIGFLPKIKQSMKKDKE 587
E+ T + +E+KS+ + I +YM+HLGV+ K + K GR F K+ + + D+
Sbjct: 218 EMQHTI-STDEEKSAAVVNAIGLYMRHLGVRTKSG---DKKSGRNFFRKKVMGNRRSDEP 273
Query: 588 GEEKGKRRGFPSIL-------GPPRRPS-RHDNSAIGRAMELQKARHPKHLSTPSSVSPE 639
+ K +G SIL G P+ P RH + + A P V
Sbjct: 274 AKTK---KGLSSILDAARWNRGEPQVPDFRHLKAEVD-------AEKPGATDRKGGVGMP 323
Query: 640 PQDSAKLRQSGLANEGTDAGYLPANSMSSVASGASFSQEGGKENDTGSKQVGETSAPGDT 699
+D R G + T L S+ S +E G + ++G++S G
Sbjct: 324 SRD----RNIGAPGQDTPGVSLHPLSLDSP------DREPGAD---APLELGDSSPQG-- 368
Query: 700 LDGTPRTLNTVFDFPPPPLDQVQEEECEVERVTEHGTPKPFRKFDSVAFGESQSEDEQFE 759
P +L ++ PP D+ E E +P+P + GE + E
Sbjct: 369 ----PMSLESLA--PPESTDEGAETE----------SPEPGDE------GEPGRSGLELE 406
Query: 760 NDLETDPPNWQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSR 819
+ +PP W++LV + L L ++KRQEVI+EL TE AHVR L+VL +F+Q ++
Sbjct: 407 PE---EPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAE 463
Query: 820 EGILSPSELRKIFSNLEDILQLH-IGLNEQMKAVRKRNETSVIDQIGEDLLTWFSGPGEE 878
EL+ IF +L++++++H + L+ MK R++ +I++IG+ LL F G
Sbjct: 464 CLFFPLEELQNIFPSLDELIEVHSLFLDRLMK--RRQESGYLIEEIGDVLLARFDGAEGS 521
Query: 879 KLKHAAATFCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLT 938
+ ++ FCS Q FALE +K++Q+KD RF FVQ+AES P CRRLQLKD+IPT+MQRLT
Sbjct: 522 WFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLT 581
Query: 939 KYPLLLDNIAKYTEWPTEREKVKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSS 998
KYPLLL +I + TE PTEREKV+ AA+ CR+IL++VNQAV++ E+ RL+DYQRRLD S
Sbjct: 582 KYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSH 641
Query: 999 LKLSEYPNVEELRNLDLTKRKMIHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDDRLV 1058
L+ S P + E +NLD+TK+K++HEGPL W+V +DK ++++ LLL+D+L+LLQ+QD+RL+
Sbjct: 642 LRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLL 701
Query: 1059 LRCHSKILASTADSKHTFSPVIKLSTVLVRQVATDNKALFVISMSDNGAQIYELVAQTVS 1118
L+ HS+ L T D K PV++L++ + R+VATD+KA +V+ D AQIYELVAQTVS
Sbjct: 702 LKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVS 761
Query: 1119 EKTVWQDLICRMAASVK----EQSTKPIPLPQST 1148
E+ W LI A S+K KP P P ST
Sbjct: 762 ERKNWCALITETAGSLKVPAPASRPKPRPSPSST 795
>gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [Homo
sapiens]
Length = 912
Score = 525 bits (1352), Expect = e-148
Identities = 327/814 (40%), Positives = 481/814 (59%), Gaps = 71/814 (8%)
Query: 350 IIGAEDDDFGTEHE-QINGQCSCFQSIELLKSRPAHLAVFLHHVVSQFDPATLLCYLYSD 408
IIGAED+DF E E Q S FQS+E +K RPAHL L HV QF+P LLC L++D
Sbjct: 23 IIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLMALLQHVALQFEPGPLLCCLHAD 82
Query: 409 LYKHTNSKETRRIFLEFHQFFLDRSAHLKVSVPDEMSADLEKRRPELIPEDLHRHYIQTM 468
+ KE ++ FL+F+ FL+++A L+V VP ++ +L++ R +LI ED+ R ++Q +
Sbjct: 83 MLGSLGPKEAKKAFLDFYHSFLEKTAVLRVPVPPNVAFELDRTRADLISEDVQRRFVQEV 142
Query: 469 QERVHPEVQRHLEDFRQKRSMGLTLAESELTKLDAERDKDRLTLE-KERTCAEQIVAKIE 527
+ V R LEDFR KR MG+T E EL +L+A +DR + E +ER AE+++ +E
Sbjct: 143 VQSQQVAVGRQLEDFRSKRLMGMTPWEQELAQLEAWVGRDRASYEARERHVAERLLMHLE 202
Query: 528 EVLMTAQAVEEDKSSTMQYVILMYMKHLGVKVKEPRNLEHKRGRIGFLPKIKQSMKKDKE 587
E+ T + +E+KS+ + I +YM+HLGV+ K + K GR F K+ + + D+
Sbjct: 203 EMQHTI-STDEEKSAAVVNAIGLYMRHLGVRTKSG---DKKSGRNFFRKKVMGNRRSDEP 258
Query: 588 GEEKGKRRGFPSIL-------GPPRRPS-RHDNSAIGRAMELQKARHPKHLSTPSSVSPE 639
+ K +G SIL G P+ P RH + + A P V
Sbjct: 259 AKTK---KGLSSILDAARWNRGEPQVPDFRHLKAEVD-------AEKPGATDRKGGVGMP 308
Query: 640 PQDSAKLRQSGLANEGTDAGYLPANSMSSVASGASFSQEGGKENDTGSKQVGETSAPGDT 699
+D R G + T L S+ S +E G + ++G++S G
Sbjct: 309 SRD----RNIGAPGQDTPGVSLHPLSLDSP------DREPGAD---APLELGDSSPQG-- 353
Query: 700 LDGTPRTLNTVFDFPPPPLDQVQEEECEVERVTEHGTPKPFRKFDSVAFGESQSEDEQFE 759
P +L ++ PP D+ E E +P+P + GE + E
Sbjct: 354 ----PMSLESLA--PPESTDEGAETE----------SPEPGDE------GEPGRSGLELE 391
Query: 760 NDLETDPPNWQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSR 819
+ +PP W++LV + L L ++KRQEVI+EL TE AHVR L+VL +F+Q ++
Sbjct: 392 PE---EPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAE 448
Query: 820 EGILSPSELRKIFSNLEDILQLH-IGLNEQMKAVRKRNETSVIDQIGEDLLTWFSGPGEE 878
EL+ IF +L++++++H + L+ MK R++ +I++IG+ LL F G
Sbjct: 449 CLFFPLEELQNIFPSLDELIEVHSLFLDRLMK--RRQESGYLIEEIGDVLLARFDGAEGS 506
Query: 879 KLKHAAATFCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLT 938
+ ++ FCS Q FALE +K++Q+KD RF FVQ+AES P CRRLQLKD+IPT+MQRLT
Sbjct: 507 WFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLT 566
Query: 939 KYPLLLDNIAKYTEWPTEREKVKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSS 998
KYPLLL +I + TE PTEREKV+ AA+ CR+IL++VNQAV++ E+ RL+DYQRRLD S
Sbjct: 567 KYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSH 626
Query: 999 LKLSEYPNVEELRNLDLTKRKMIHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDDRLV 1058
L+ S P + E +NLD+TK+K++HEGPL W+V +DK ++++ LLL+D+L+LLQ+QD+RL+
Sbjct: 627 LRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLL 686
Query: 1059 LRCHSKILASTADSKHTFSPVIKLSTVLVRQVATDNKALFVISMSDNGAQIYELVAQTVS 1118
L+ HS+ L T D K PV++L++ + R+VATD+KA +V+ D AQIYELVAQTVS
Sbjct: 687 LKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVS 746
Query: 1119 EKTVWQDLICRMAASVK----EQSTKPIPLPQST 1148
E+ W LI A S+K KP P P ST
Sbjct: 747 ERKNWCALITETAGSLKVPAPASRPKPRPSPSST 780
>gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [Homo
sapiens]
Length = 879
Score = 483 bits (1242), Expect = e-136
Identities = 315/814 (38%), Positives = 460/814 (56%), Gaps = 104/814 (12%)
Query: 350 IIGAEDDDFGTEHE-QINGQCSCFQSIELLKSRPAHLAVFLHHVVSQFDPATLLCYLYSD 408
IIGAED+DF E E Q S FQS+E +K RPAHL L HV QF+P L+
Sbjct: 23 IIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLMALLQHVALQFEPGPLV------ 76
Query: 409 LYKHTNSKETRRIFLEFHQFFLDRSAHLKVSVPDEMSADLEKRRPELIPEDLHRHYIQTM 468
L+V VP ++ +L++ R +LI ED+ R ++Q +
Sbjct: 77 ---------------------------LRVPVPPNVAFELDRTRADLISEDVQRRFVQEV 109
Query: 469 QERVHPEVQRHLEDFRQKRSMGLTLAESELTKLDAERDKDRLTLE-KERTCAEQIVAKIE 527
+ V R LEDFR KR MG+T E EL +L+A +DR + E +ER AE+++ +E
Sbjct: 110 VQSQQVAVGRQLEDFRSKRLMGMTPWEQELAQLEAWVGRDRASYEARERHVAERLLMHLE 169
Query: 528 EVLMTAQAVEEDKSSTMQYVILMYMKHLGVKVKEPRNLEHKRGRIGFLPKIKQSMKKDKE 587
E+ T + +E+KS+ + I +YM+HLGV+ K + K GR F K+ + + D+
Sbjct: 170 EMQHTI-STDEEKSAAVVNAIGLYMRHLGVRTKSG---DKKSGRNFFRKKVMGNRRSDEP 225
Query: 588 GEEKGKRRGFPSIL-------GPPRRPS-RHDNSAIGRAMELQKARHPKHLSTPSSVSPE 639
+ K +G SIL G P+ P RH + + A P V
Sbjct: 226 AKTK---KGLSSILDAARWNRGEPQVPDFRHLKAEVD-------AEKPGATDRKGGVGMP 275
Query: 640 PQDSAKLRQSGLANEGTDAGYLPANSMSSVASGASFSQEGGKENDTGSKQVGETSAPGDT 699
+D R G + T L S+ S +E G + ++G++S G
Sbjct: 276 SRD----RNIGAPGQDTPGVSLHPLSLDSP------DREPGAD---APLELGDSSPQG-- 320
Query: 700 LDGTPRTLNTVFDFPPPPLDQVQEEECEVERVTEHGTPKPFRKFDSVAFGESQSEDEQFE 759
P +L ++ PP D+ E E +P+P + GE + E
Sbjct: 321 ----PMSLESLA--PPESTDEGAETE----------SPEPGDE------GEPGRSGLELE 358
Query: 760 NDLETDPPNWQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSR 819
+ +PP W++LV + L L ++KRQEVI+EL TE AHVR L+VL +F+Q ++
Sbjct: 359 PE---EPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAE 415
Query: 820 EGILSPSELRKIFSNLEDILQLH-IGLNEQMKAVRKRNETSVIDQIGEDLLTWFSGPGEE 878
EL+ IF +L++++++H + L+ MK R++ +I++IG+ LL F G
Sbjct: 416 CLFFPLEELQNIFPSLDELIEVHSLFLDRLMK--RRQESGYLIEEIGDVLLARFDGAEGS 473
Query: 879 KLKHAAATFCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLT 938
+ ++ FCS Q FALE +K++Q+KD RF FVQ+AES P CRRLQLKD+IPT+MQRLT
Sbjct: 474 WFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLT 533
Query: 939 KYPLLLDNIAKYTEWPTEREKVKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSS 998
KYPLLL +I + TE PTEREKV+ AA+ CR+IL++VNQAV++ E+ RL+DYQRRLD S
Sbjct: 534 KYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSH 593
Query: 999 LKLSEYPNVEELRNLDLTKRKMIHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDDRLV 1058
L+ S P + E +NLD+TK+K++HEGPL W+V +DK ++++ LLL+D+L+LLQ+QD+RL+
Sbjct: 594 LRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLL 653
Query: 1059 LRCHSKILASTADSKHTFSPVIKLSTVLVRQVATDNKALFVISMSDNGAQIYELVAQTVS 1118
L+ HS+ L T D K PV++L++ + R+VATD+KA +V+ D AQIYELVAQTVS
Sbjct: 654 LKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVS 713
Query: 1119 EKTVWQDLICRMAASVK----EQSTKPIPLPQST 1148
E+ W LI A S+K KP P P ST
Sbjct: 714 ERKNWCALITETAGSLKVPAPASRPKPRPSPSST 747
>gi|195972857 Rho/Rac guanine nucleotide exchange factor 18 isoform b
[Homo sapiens]
Length = 1173
Score = 183 bits (464), Expect = 1e-45
Identities = 127/429 (29%), Positives = 219/429 (51%), Gaps = 29/429 (6%)
Query: 750 ESQSEDEQFENDLETDPPNWQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTLKVL 809
E +S+ +FE + +W V K +KRQ+V+ EL TE HVRTLK++
Sbjct: 228 EIESDGHEFEAE------SWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIM 281
Query: 810 DQVFYQRVSREGILSPSELRKIFSNLEDILQLHIGLNEQMKAVRKRN------ETSVIDQ 863
+V+ + + E S + ++F +D+L+ H ++K R+ + VI +
Sbjct: 282 LKVYSRALQEELQFSSKAIGRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQK 341
Query: 864 IGEDLLTWFSGPGEEKLKHAAATFCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLCRR 923
IG+ L+ FSG E++K FCS A+ K +++ +FQ ++ + + RR
Sbjct: 342 IGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRR 401
Query: 924 LQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPTE-REKVKKAADHCRQILNYVNQAVKEAE 982
L +++ I QR+TKYP+L++ I + TE TE E + +A + + I++ V+ V E E
Sbjct: 402 LGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECE 461
Query: 983 NKQRLEDYQRRLDTSSLKLSEYPNVEELRNLDLTKRKMIHEGPLVWKVNRDKTIDLYTLL 1042
QRL + ++D S S+ N R D+ +R++ EG L WK + D+ +L
Sbjct: 462 KGQRLREIAGKMDLKS--SSKLKNGLTFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAIL 519
Query: 1043 LEDILVLLQKQDDRLVLRCHSKILASTADSKHTFSPVIKLSTVLVRQVATDNKALFVISM 1102
L D+L+LLQ++D + V ++ DSK PVI L ++VR+VA + KA+F+IS
Sbjct: 520 LTDVLLLLQEKDQKYVF--------ASVDSK---PPVISLQKLIVREVANEEKAMFLISA 568
Query: 1103 SDNGAQIYELVAQTVSEKTVWQDLICRMAASVKEQSTKPIPLPQSTPGEGDNDEEDPSKL 1162
S G ++YE+ + ++ W I R S ++ P LP+ E E ++L
Sbjct: 569 SLQGPEMYEIYTSSKEDRNAWMAHIQRAVESCPDEEEGPFSLPEE---ERKVVEARATRL 625
Query: 1163 KEEQHGISV 1171
++ Q +S+
Sbjct: 626 RDFQERLSM 634
>gi|41327769 Rho/Rac guanine nucleotide exchange factor 18 isoform a
[Homo sapiens]
Length = 1015
Score = 183 bits (464), Expect = 1e-45
Identities = 127/429 (29%), Positives = 219/429 (51%), Gaps = 29/429 (6%)
Query: 750 ESQSEDEQFENDLETDPPNWQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTLKVL 809
E +S+ +FE + +W V K +KRQ+V+ EL TE HVRTLK++
Sbjct: 70 EIESDGHEFEAE------SWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIM 123
Query: 810 DQVFYQRVSREGILSPSELRKIFSNLEDILQLHIGLNEQMKAVRKRN------ETSVIDQ 863
+V+ + + E S + ++F +D+L+ H ++K R+ + VI +
Sbjct: 124 LKVYSRALQEELQFSSKAIGRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQK 183
Query: 864 IGEDLLTWFSGPGEEKLKHAAATFCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLCRR 923
IG+ L+ FSG E++K FCS A+ K +++ +FQ ++ + + RR
Sbjct: 184 IGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRR 243
Query: 924 LQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPTE-REKVKKAADHCRQILNYVNQAVKEAE 982
L +++ I QR+TKYP+L++ I + TE TE E + +A + + I++ V+ V E E
Sbjct: 244 LGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECE 303
Query: 983 NKQRLEDYQRRLDTSSLKLSEYPNVEELRNLDLTKRKMIHEGPLVWKVNRDKTIDLYTLL 1042
QRL + ++D S S+ N R D+ +R++ EG L WK + D+ +L
Sbjct: 304 KGQRLREIAGKMDLKS--SSKLKNGLTFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAIL 361
Query: 1043 LEDILVLLQKQDDRLVLRCHSKILASTADSKHTFSPVIKLSTVLVRQVATDNKALFVISM 1102
L D+L+LLQ++D + V ++ DSK PVI L ++VR+VA + KA+F+IS
Sbjct: 362 LTDVLLLLQEKDQKYVF--------ASVDSK---PPVISLQKLIVREVANEEKAMFLISA 410
Query: 1103 SDNGAQIYELVAQTVSEKTVWQDLICRMAASVKEQSTKPIPLPQSTPGEGDNDEEDPSKL 1162
S G ++YE+ + ++ W I R S ++ P LP+ E E ++L
Sbjct: 411 SLQGPEMYEIYTSSKEDRNAWMAHIQRAVESCPDEEEGPFSLPEE---ERKVVEARATRL 467
Query: 1163 KEEQHGISV 1171
++ Q +S+
Sbjct: 468 RDFQERLSM 476
>gi|253735778 Rho/Rac guanine nucleotide exchange factor 2 isoform 2
[Homo sapiens]
Length = 985
Score = 171 bits (433), Expect = 5e-42
Identities = 138/546 (25%), Positives = 248/546 (45%), Gaps = 56/546 (10%)
Query: 643 SAKLRQSGLANEGTDAGYLPANSMSSVASGASFSQEGGKENDTGSKQVGETSAPGDTLDG 702
S LR E + P++S G+ G+ + + +K V T+ G D
Sbjct: 107 SVSLRSKTTIRERPSSAIYPSDSFRQSLLGS----RRGRSSLSLAKSVSTTNIAGHFNDE 162
Query: 703 TPRTLNTVFDFPPPPLDQVQEEECEVERVTEHGTPKPFRKFDSVAFGESQSEDEQFENDL 762
+P L + L+ ++ VE + + + V + E S+ E E D
Sbjct: 163 SPLGLRRILSQSTDSLN-MRNRTLSVESLID----------EEVIYSELMSDFEMDEKDF 211
Query: 763 ETDPPNWQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGI 822
D +W V L K +K+Q+VI EL TE HVRTLK++ ++F + E
Sbjct: 212 AAD--SWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELH 269
Query: 823 LSPSELRKIFSNLEDILQLHIGLNEQMKAVRKR------NETSVIDQIGEDLLTWFSGPG 876
L P ++ +F ++++ +H Q+ R++ VI ++G+ L++ FSGP
Sbjct: 270 LEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPS 329
Query: 877 EEKLKHAAATFCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQR 936
E++ + FCS AL++ K +D RFQ F++ + +R +++ I QR
Sbjct: 330 AEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQR 389
Query: 937 LTKYPLLLDNIAKYTEW-PTEREKVKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLD 995
+TKYPLL+ I +++ ER+ + A +++L+ V++ + + E RL++ R+D
Sbjct: 390 ITKYPLLISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMD 449
Query: 996 TSSLKLSEYPNVEELRNLDLTKRKMIHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDD 1055
+ + P +L +RK+IH+G L+WK + D+ LL+ D+LV LQ++D
Sbjct: 450 PRA--QTPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQ 507
Query: 1056 RLVLRCHSKILASTADSKHTFSPVIKLSTVLVRQVATDNKALFVISMSDNGAQIYELVAQ 1115
+ + K V+ L ++VR +A K +F+IS + ++YE+
Sbjct: 508 KYIFPTLDK------------PSVVSLQNLIVRDIANQEKGMFLISAAP--PEMYEVHTA 553
Query: 1116 TVSEKTVWQDLICRMAASVKEQSTKPIPLPQSTPGEGDNDEEDPSKLKEEQHGISVTGLQ 1175
+ +++ W +I +QS + P + P DE ++K E LQ
Sbjct: 554 SRDDRSTWIRVI--------QQSVRTCPSREDFPLIETEDEAYLRRIKME--------LQ 597
Query: 1176 SPDRDL 1181
DR L
Sbjct: 598 QKDRAL 603
>gi|15011974 Rho/Rac guanine nucleotide exchange factor 2 isooform 3
[Homo sapiens]
Length = 958
Score = 171 bits (433), Expect = 5e-42
Identities = 138/546 (25%), Positives = 248/546 (45%), Gaps = 56/546 (10%)
Query: 643 SAKLRQSGLANEGTDAGYLPANSMSSVASGASFSQEGGKENDTGSKQVGETSAPGDTLDG 702
S LR E + P++S G+ G+ + + +K V T+ G D
Sbjct: 80 SVSLRSKTTIRERPSSAIYPSDSFRQSLLGS----RRGRSSLSLAKSVSTTNIAGHFNDE 135
Query: 703 TPRTLNTVFDFPPPPLDQVQEEECEVERVTEHGTPKPFRKFDSVAFGESQSEDEQFENDL 762
+P L + L+ ++ VE + + + V + E S+ E E D
Sbjct: 136 SPLGLRRILSQSTDSLN-MRNRTLSVESLID----------EEVIYSELMSDFEMDEKDF 184
Query: 763 ETDPPNWQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGI 822
D +W V L K +K+Q+VI EL TE HVRTLK++ ++F + E
Sbjct: 185 AAD--SWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELH 242
Query: 823 LSPSELRKIFSNLEDILQLHIGLNEQMKAVRKR------NETSVIDQIGEDLLTWFSGPG 876
L P ++ +F ++++ +H Q+ R++ VI ++G+ L++ FSGP
Sbjct: 243 LEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPS 302
Query: 877 EEKLKHAAATFCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQR 936
E++ + FCS AL++ K +D RFQ F++ + +R +++ I QR
Sbjct: 303 AEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQR 362
Query: 937 LTKYPLLLDNIAKYTEW-PTEREKVKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLD 995
+TKYPLL+ I +++ ER+ + A +++L+ V++ + + E RL++ R+D
Sbjct: 363 ITKYPLLISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMD 422
Query: 996 TSSLKLSEYPNVEELRNLDLTKRKMIHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDD 1055
+ + P +L +RK+IH+G L+WK + D+ LL+ D+LV LQ++D
Sbjct: 423 PRA--QTPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQ 480
Query: 1056 RLVLRCHSKILASTADSKHTFSPVIKLSTVLVRQVATDNKALFVISMSDNGAQIYELVAQ 1115
+ + K V+ L ++VR +A K +F+IS + ++YE+
Sbjct: 481 KYIFPTLDK------------PSVVSLQNLIVRDIANQEKGMFLISAAP--PEMYEVHTA 526
Query: 1116 TVSEKTVWQDLICRMAASVKEQSTKPIPLPQSTPGEGDNDEEDPSKLKEEQHGISVTGLQ 1175
+ +++ W +I +QS + P + P DE ++K E LQ
Sbjct: 527 SRDDRSTWIRVI--------QQSVRTCPSREDFPLIETEDEAYLRRIKME--------LQ 570
Query: 1176 SPDRDL 1181
DR L
Sbjct: 571 QKDRAL 576
>gi|253735775 Rho/Rac guanine nucleotide exchange factor 2 isoform 1
[Homo sapiens]
Length = 986
Score = 171 bits (432), Expect = 7e-42
Identities = 138/546 (25%), Positives = 247/546 (45%), Gaps = 55/546 (10%)
Query: 643 SAKLRQSGLANEGTDAGYLPANSMSSVASGASFSQEGGKENDTGSKQVGETSAPGDTLDG 702
S LR E + P++S G+ G+ + + +K V T+ G D
Sbjct: 107 SVSLRSKTTIRERPSSAIYPSDSFRQSLLGS----RRGRSSLSLAKSVSTTNIAGHFNDE 162
Query: 703 TPRTLNTVFDFPPPPLDQVQEEECEVERVTEHGTPKPFRKFDSVAFGESQSEDEQFENDL 762
+P L + L+ ++ VE + + V + E S+ E E D
Sbjct: 163 SPLGLRRILSQSTDSLN-MRNRTLSVESLIDEA---------EVIYSELMSDFEMDEKDF 212
Query: 763 ETDPPNWQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGI 822
D +W V L K +K+Q+VI EL TE HVRTLK++ ++F + E
Sbjct: 213 AAD--SWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELH 270
Query: 823 LSPSELRKIFSNLEDILQLHIGLNEQMKAVRKR------NETSVIDQIGEDLLTWFSGPG 876
L P ++ +F ++++ +H Q+ R++ VI ++G+ L++ FSGP
Sbjct: 271 LEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPS 330
Query: 877 EEKLKHAAATFCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQR 936
E++ + FCS AL++ K +D RFQ F++ + +R +++ I QR
Sbjct: 331 AEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQR 390
Query: 937 LTKYPLLLDNIAKYTEW-PTEREKVKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLD 995
+TKYPLL+ I +++ ER+ + A +++L+ V++ + + E RL++ R+D
Sbjct: 391 ITKYPLLISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMD 450
Query: 996 TSSLKLSEYPNVEELRNLDLTKRKMIHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDD 1055
+ + P +L +RK+IH+G L+WK + D+ LL+ D+LV LQ++D
Sbjct: 451 PRA--QTPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQ 508
Query: 1056 RLVLRCHSKILASTADSKHTFSPVIKLSTVLVRQVATDNKALFVISMSDNGAQIYELVAQ 1115
+ + K V+ L ++VR +A K +F+IS + ++YE+
Sbjct: 509 KYIFPTLDK------------PSVVSLQNLIVRDIANQEKGMFLISAAP--PEMYEVHTA 554
Query: 1116 TVSEKTVWQDLICRMAASVKEQSTKPIPLPQSTPGEGDNDEEDPSKLKEEQHGISVTGLQ 1175
+ +++ W +I +QS + P + P DE ++K E LQ
Sbjct: 555 SRDDRSTWIRVI--------QQSVRTCPSREDFPLIETEDEAYLRRIKME--------LQ 598
Query: 1176 SPDRDL 1181
DR L
Sbjct: 599 QKDRAL 604
>gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens]
Length = 2817
Score = 169 bits (427), Expect = 2e-41
Identities = 124/463 (26%), Positives = 221/463 (47%), Gaps = 42/463 (9%)
Query: 718 LDQVQEEECEVERVTEHGTPKPFRKFDSVAFGESQSEDEQFENDLETDPPNWQQLVSREV 777
L+++ + E +T+ G + G+ + E +Q E + +W +++ +
Sbjct: 1937 LNKISKVNESTESLTDEGVGTDMN--EGQLLGDFEIESKQLEAE------SWSRIIDSKF 1988
Query: 778 LLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSELRKIFSNLED 837
L K +KRQEVI EL TE HVRTLK++ V+ Q + + + + K+F L++
Sbjct: 1989 LKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDE 2048
Query: 838 ILQLHIGLNEQM------KAVRKRNETSVIDQIGEDLLTWFSGPGEEKLKHAAATFCSNQ 891
++ +H +++ V K + +I +IG+ L+ FSG E+LK FC
Sbjct: 2049 LISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQH 2108
Query: 892 PFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYT 951
++ K KD RFQ FV+ S+ + RRL + + I QR+TKYP+L I + T
Sbjct: 2109 NQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCT 2168
Query: 952 -EWPTEREKVKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSSLKLSEYPNVEEL 1010
+ E+E + ++ + ++ V+ V E K RL + + D+ S + + +
Sbjct: 2169 KDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKS--IMRMKSGQMF 2226
Query: 1011 RNLDLTKRKMIHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDDRLVLRCHSKILASTA 1070
DL ++K++ +G + K + ++ +LL DILV LQ++D K + ++
Sbjct: 2227 AKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKD--------QKYIFASL 2278
Query: 1071 DSKHTFSPVIKLSTVLVRQVATDNKALFVISMSDNGAQIYELVAQTVSEKTVWQDLICRM 1130
D K T VI L ++VR+VA + K LF+ISM ++ E+ A + E+ W +I
Sbjct: 2279 DQKST---VISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDT 2335
Query: 1131 AASVKEQSTKPIPLPQSTPGEGDNDEED------PSKLKEEQH 1167
++ + IP +N+EE +LKE+ H
Sbjct: 2336 INTLNRDEDEGIP--------SENEEEKKMLDTRARELKEQLH 2370
>gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens]
Length = 1058
Score = 169 bits (427), Expect = 2e-41
Identities = 124/463 (26%), Positives = 221/463 (47%), Gaps = 42/463 (9%)
Query: 718 LDQVQEEECEVERVTEHGTPKPFRKFDSVAFGESQSEDEQFENDLETDPPNWQQLVSREV 777
L+++ + E +T+ G + G+ + E +Q E + +W +++ +
Sbjct: 178 LNKISKVNESTESLTDEGVGTDMN--EGQLLGDFEIESKQLEAE------SWSRIIDSKF 229
Query: 778 LLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSELRKIFSNLED 837
L K +KRQEVI EL TE HVRTLK++ V+ Q + + + + K+F L++
Sbjct: 230 LKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDE 289
Query: 838 ILQLHIGLNEQM------KAVRKRNETSVIDQIGEDLLTWFSGPGEEKLKHAAATFCSNQ 891
++ +H +++ V K + +I +IG+ L+ FSG E+LK FC
Sbjct: 290 LISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQH 349
Query: 892 PFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYT 951
++ K KD RFQ FV+ S+ + RRL + + I QR+TKYP+L I + T
Sbjct: 350 NQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCT 409
Query: 952 -EWPTEREKVKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSSLKLSEYPNVEEL 1010
+ E+E + ++ + ++ V+ V E K RL + + D+ S + + +
Sbjct: 410 KDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKS--IMRMKSGQMF 467
Query: 1011 RNLDLTKRKMIHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDDRLVLRCHSKILASTA 1070
DL ++K++ +G + K + ++ +LL DILV LQ++D K + ++
Sbjct: 468 AKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKD--------QKYIFASL 519
Query: 1071 DSKHTFSPVIKLSTVLVRQVATDNKALFVISMSDNGAQIYELVAQTVSEKTVWQDLICRM 1130
D K T VI L ++VR+VA + K LF+ISM ++ E+ A + E+ W +I
Sbjct: 520 DQKST---VISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDT 576
Query: 1131 AASVKEQSTKPIPLPQSTPGEGDNDEED------PSKLKEEQH 1167
++ + IP +N+EE +LKE+ H
Sbjct: 577 INTLNRDEDEGIP--------SENEEEKKMLDTRARELKEQLH 611
>gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens]
Length = 2813
Score = 169 bits (427), Expect = 2e-41
Identities = 124/463 (26%), Positives = 221/463 (47%), Gaps = 42/463 (9%)
Query: 718 LDQVQEEECEVERVTEHGTPKPFRKFDSVAFGESQSEDEQFENDLETDPPNWQQLVSREV 777
L+++ + E +T+ G + G+ + E +Q E + +W +++ +
Sbjct: 1933 LNKISKVNESTESLTDEGVGTDMN--EGQLLGDFEIESKQLEAE------SWSRIIDSKF 1984
Query: 778 LLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSELRKIFSNLED 837
L K +KRQEVI EL TE HVRTLK++ V+ Q + + + + K+F L++
Sbjct: 1985 LKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDE 2044
Query: 838 ILQLHIGLNEQM------KAVRKRNETSVIDQIGEDLLTWFSGPGEEKLKHAAATFCSNQ 891
++ +H +++ V K + +I +IG+ L+ FSG E+LK FC
Sbjct: 2045 LISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQH 2104
Query: 892 PFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYT 951
++ K KD RFQ FV+ S+ + RRL + + I QR+TKYP+L I + T
Sbjct: 2105 NQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCT 2164
Query: 952 -EWPTEREKVKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSSLKLSEYPNVEEL 1010
+ E+E + ++ + ++ V+ V E K RL + + D+ S + + +
Sbjct: 2165 KDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKS--IMRMKSGQMF 2222
Query: 1011 RNLDLTKRKMIHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDDRLVLRCHSKILASTA 1070
DL ++K++ +G + K + ++ +LL DILV LQ++D K + ++
Sbjct: 2223 AKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKD--------QKYIFASL 2274
Query: 1071 DSKHTFSPVIKLSTVLVRQVATDNKALFVISMSDNGAQIYELVAQTVSEKTVWQDLICRM 1130
D K T VI L ++VR+VA + K LF+ISM ++ E+ A + E+ W +I
Sbjct: 2275 DQKST---VISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDT 2331
Query: 1131 AASVKEQSTKPIPLPQSTPGEGDNDEED------PSKLKEEQH 1167
++ + IP +N+EE +LKE+ H
Sbjct: 2332 INTLNRDEDEGIP--------SENEEEKKMLDTRARELKEQLH 2366
>gi|122937434 Rho-guanine nucleotide exchange factor [Homo sapiens]
Length = 1651
Score = 167 bits (424), Expect = 6e-41
Identities = 132/494 (26%), Positives = 235/494 (47%), Gaps = 44/494 (8%)
Query: 744 DSVAFGESQSEDEQFENDLETDPPNWQQLVSREVLLGLKPCEIKRQEVINELFYTERAHV 803
DS + + S+ ++FE + +W +V + IKRQ+VI EL TE H+
Sbjct: 812 DSSLWSDLSSDAQEFEAE------SWSLVVDPSFCNRQEKDVIKRQDVIFELMQTEMHHI 865
Query: 804 RTLKVLDQVFYQRVSREGILSPSELRKIFSNLEDILQLHIGLNEQMKAVRKR-----NET 858
+TL ++ ++F + + E L S + KIF L+++L++H MK R+ +
Sbjct: 866 QTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDELLEIHRHFFYSMKERRQESCAGSDRN 925
Query: 859 SVIDQIGEDLLTWFSGPGEEKLKHAAATFCSNQPFALEMIKSRQKKDSRFQTFVQDAESN 918
VID+IG+ L+ FS K+K FC + A+ + K Q ++ +FQ F++ SN
Sbjct: 926 FVIDRIGDILVQQFSEENASKMKKIYGEFCCHHKEAVNLFKELQ-QNKKFQNFIKLRNSN 984
Query: 919 PLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPTEREK-VKKAADHCRQILNYVNQA 977
L RR + + I QR+TKYP+L++ I +YT+ TE K ++KA + ++ V+
Sbjct: 985 LLARRRGIPECILLVTQRITKYPVLVERILQYTKERTEEHKDLRKALCLIKDMIATVDLK 1044
Query: 978 VKEAENKQRLEDYQRRLDTSSLKLSEYPNVEELRNLDLTKRKMIHEGPLVWKVNRDKTID 1037
V E E Q+ + +++ + + +V + L +R ++++G + WK + D
Sbjct: 1045 VNEYEKNQKWLEILNKIENKTYTKLKNGHVFRKQALMSEERTLLYDGLVYWKTATGRFKD 1104
Query: 1038 LYTLLLEDILVLLQKQDDRLVLRCHSKILASTADSKHTFSPVIKLSTVLVRQVATDNKAL 1097
+ LLL D+L+ LQ++D K + + D K + VI L ++ R+VA + + +
Sbjct: 1105 ILALLLTDVLLFLQEKD--------QKYIFAAVDQKPS---VISLQKLIAREVANEERGM 1153
Query: 1098 FVISMSDNGAQIYELVAQTVSEKTVWQDLICRMAASVKEQ---------------STKPI 1142
F+IS S G ++YE+ + E+ W I + S E+ +
Sbjct: 1154 FLISASSAGPEMYEIHTNSKEERNNWMRRIQQAVESCPEEKGGRTSESDEDKRKAEARVA 1213
Query: 1143 PLPQSTPGEGDNDEEDPSKLKEEQHGISVTGLQSPDRDLGLESTLI-----SSKPQSHSL 1197
+ Q + D++ + L+E+ H + G S D+ LE L+ PQ+ SL
Sbjct: 1214 KIQQCQEILTNQDQQICAYLEEKLHIYAELGELSGFEDVHLEPHLLIKPDPGEPPQAASL 1273
Query: 1198 STSGKSEVRDLFVA 1211
+ E L VA
Sbjct: 1274 LAAALKEAESLQVA 1287
>gi|38373682 pleckstrin homology domain containing family G member 5
isoform a [Homo sapiens]
Length = 1006
Score = 145 bits (367), Expect = 2e-34
Identities = 159/673 (23%), Positives = 287/673 (42%), Gaps = 80/673 (11%)
Query: 573 GFLPKIKQSMKKDKEGEEKGKRRGFPSILGPPRRPSRHDNSAIGRAMELQKARHPKHLST 632
G ++K K EG+ + + S+ P RP+ A+ R ++ Q R +
Sbjct: 140 GHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPPALER-VDAQSRRESLDILA 198
Query: 633 PSSVSPEPQDSAKLRQSGLANEGTDAGYLPANSMS-SVASGASFSQEGGK--ENDTGSKQ 689
P + S E + G P S S+ SG+S S G +N S+
Sbjct: 199 PGR--------RRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNTGDSWKNRAASRF 250
Query: 690 VGE-TSAPGDTLDGTPRTLNTVFDFPPPPLDQVQEEECEVERVTEHGTPKPFR--KFDSV 746
G +S P + G +D++++ E ++ + G P+ R +FD
Sbjct: 251 SGFFSSGPSTSAFGRE-------------VDKMEQLEGKLHTYSLFGLPRLPRGLRFDHD 297
Query: 747 AFGESQSEDEQFENDLETDPPNWQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTL 806
++ E EDE +N +W++L+ L + C +QE + EL +TE +++R L
Sbjct: 298 SWEEEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCH--QQEAVWELLHTEASYIRKL 355
Query: 807 KVLDQVFY---QRVSREGILSPSELRKIFSNLEDILQLHIGLNEQMKA--VRKRNETSVI 861
+V+ +F + G+L E ++FSN+ +I QLH L + A + K T +
Sbjct: 356 RVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRAL 415
Query: 862 DQIGEDLLTWFSGPGEEKLKHAAATFCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLC 921
Q G D L F G L +C + +E ++ + + F+ ++ AE +P C
Sbjct: 416 LQPG-DFLKGFKMFGS--LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQC 472
Query: 922 RRLQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPTEREKVKKAADHCRQILNYVNQAVKEA 981
+RL+L D++ QRLTKYPLLL ++ + TE P +E V + +++VN +++
Sbjct: 473 QRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQR 532
Query: 982 ENKQRLEDYQRRLDTSSLKLSEYPNVE----ELRNLDLT----------KRKMIHEGPLV 1027
+ +QRL R+D + S V+ E +LDLT R+++ EG L
Sbjct: 533 QERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLR 592
Query: 1028 WKVNRDKTIDLYTLLLEDILVLLQKQDDRLVLRCHSKILASTADSKHTFSPVIKLSTVLV 1087
K +D +D+Y L D+L++ + A+ P + + ++
Sbjct: 593 MKEGKDSKMDVYCFLFTDLLLVTK--------------AVKKAERTRVIRPPLLVDKIVC 638
Query: 1088 RQVATDNKALFVI---SMSDNGAQIYELVAQTVSE---KTVW--QDLICRMAASVKEQST 1139
R++ L + S GA ++ Q + T++ Q+ + ++ A S
Sbjct: 639 RELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQ 698
Query: 1140 KPIPLPQSTPGEGDNDEEDPSKLKEEQHGISVTGLQSPDRDLGLESTLISSKPQSHSLST 1199
+P+ QS E D EE+ + +EE+ G +G + + + S P S ++
Sbjct: 699 QPL---QSLEEEEDEQEEEEEEEEEEEEG-EDSGTSAASSPTIMRKS--SGSPDSQHCAS 752
Query: 1200 SGKSEVRDLFVAE 1212
G +E + V E
Sbjct: 753 DGSTETLAMVVVE 765
>gi|111154084 pleckstrin homology domain containing family G member 5
isoform b [Homo sapiens]
Length = 1083
Score = 145 bits (367), Expect = 2e-34
Identities = 159/673 (23%), Positives = 287/673 (42%), Gaps = 80/673 (11%)
Query: 573 GFLPKIKQSMKKDKEGEEKGKRRGFPSILGPPRRPSRHDNSAIGRAMELQKARHPKHLST 632
G ++K K EG+ + + S+ P RP+ A+ R ++ Q R +
Sbjct: 217 GHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPPALER-VDAQSRRESLDILA 275
Query: 633 PSSVSPEPQDSAKLRQSGLANEGTDAGYLPANSMS-SVASGASFSQEGGK--ENDTGSKQ 689
P + S E + G P S S+ SG+S S G +N S+
Sbjct: 276 PGR--------RRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNTGDSWKNRAASRF 327
Query: 690 VGE-TSAPGDTLDGTPRTLNTVFDFPPPPLDQVQEEECEVERVTEHGTPKPFR--KFDSV 746
G +S P + G +D++++ E ++ + G P+ R +FD
Sbjct: 328 SGFFSSGPSTSAFGRE-------------VDKMEQLEGKLHTYSLFGLPRLPRGLRFDHD 374
Query: 747 AFGESQSEDEQFENDLETDPPNWQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTL 806
++ E EDE +N +W++L+ L + C +QE + EL +TE +++R L
Sbjct: 375 SWEEEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCH--QQEAVWELLHTEASYIRKL 432
Query: 807 KVLDQVFY---QRVSREGILSPSELRKIFSNLEDILQLHIGLNEQMKA--VRKRNETSVI 861
+V+ +F + G+L E ++FSN+ +I QLH L + A + K T +
Sbjct: 433 RVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRAL 492
Query: 862 DQIGEDLLTWFSGPGEEKLKHAAATFCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLC 921
Q G D L F G L +C + +E ++ + + F+ ++ AE +P C
Sbjct: 493 LQPG-DFLKGFKMFGS--LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQC 549
Query: 922 RRLQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPTEREKVKKAADHCRQILNYVNQAVKEA 981
+RL+L D++ QRLTKYPLLL ++ + TE P +E V + +++VN +++
Sbjct: 550 QRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQR 609
Query: 982 ENKQRLEDYQRRLDTSSLKLSEYPNVE----ELRNLDLT----------KRKMIHEGPLV 1027
+ +QRL R+D + S V+ E +LDLT R+++ EG L
Sbjct: 610 QERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLR 669
Query: 1028 WKVNRDKTIDLYTLLLEDILVLLQKQDDRLVLRCHSKILASTADSKHTFSPVIKLSTVLV 1087
K +D +D+Y L D+L++ + A+ P + + ++
Sbjct: 670 MKEGKDSKMDVYCFLFTDLLLVTK--------------AVKKAERTRVIRPPLLVDKIVC 715
Query: 1088 RQVATDNKALFVI---SMSDNGAQIYELVAQTVSE---KTVW--QDLICRMAASVKEQST 1139
R++ L + S GA ++ Q + T++ Q+ + ++ A S
Sbjct: 716 RELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQ 775
Query: 1140 KPIPLPQSTPGEGDNDEEDPSKLKEEQHGISVTGLQSPDRDLGLESTLISSKPQSHSLST 1199
+P+ QS E D EE+ + +EE+ G +G + + + S P S ++
Sbjct: 776 QPL---QSLEEEEDEQEEEEEEEEEEEEG-EDSGTSAASSPTIMRKS--SGSPDSQHCAS 829
Query: 1200 SGKSEVRDLFVAE 1212
G +E + V E
Sbjct: 830 DGSTETLAMVVVE 842
>gi|111154088 pleckstrin homology domain containing family G member 5
isoform a [Homo sapiens]
Length = 1006
Score = 145 bits (367), Expect = 2e-34
Identities = 159/673 (23%), Positives = 287/673 (42%), Gaps = 80/673 (11%)
Query: 573 GFLPKIKQSMKKDKEGEEKGKRRGFPSILGPPRRPSRHDNSAIGRAMELQKARHPKHLST 632
G ++K K EG+ + + S+ P RP+ A+ R ++ Q R +
Sbjct: 140 GHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPPALER-VDAQSRRESLDILA 198
Query: 633 PSSVSPEPQDSAKLRQSGLANEGTDAGYLPANSMS-SVASGASFSQEGGK--ENDTGSKQ 689
P + S E + G P S S+ SG+S S G +N S+
Sbjct: 199 PGR--------RRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNTGDSWKNRAASRF 250
Query: 690 VGE-TSAPGDTLDGTPRTLNTVFDFPPPPLDQVQEEECEVERVTEHGTPKPFR--KFDSV 746
G +S P + G +D++++ E ++ + G P+ R +FD
Sbjct: 251 SGFFSSGPSTSAFGRE-------------VDKMEQLEGKLHTYSLFGLPRLPRGLRFDHD 297
Query: 747 AFGESQSEDEQFENDLETDPPNWQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTL 806
++ E EDE +N +W++L+ L + C +QE + EL +TE +++R L
Sbjct: 298 SWEEEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCH--QQEAVWELLHTEASYIRKL 355
Query: 807 KVLDQVFY---QRVSREGILSPSELRKIFSNLEDILQLHIGLNEQMKA--VRKRNETSVI 861
+V+ +F + G+L E ++FSN+ +I QLH L + A + K T +
Sbjct: 356 RVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRAL 415
Query: 862 DQIGEDLLTWFSGPGEEKLKHAAATFCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLC 921
Q G D L F G L +C + +E ++ + + F+ ++ AE +P C
Sbjct: 416 LQPG-DFLKGFKMFGS--LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQC 472
Query: 922 RRLQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPTEREKVKKAADHCRQILNYVNQAVKEA 981
+RL+L D++ QRLTKYPLLL ++ + TE P +E V + +++VN +++
Sbjct: 473 QRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQR 532
Query: 982 ENKQRLEDYQRRLDTSSLKLSEYPNVE----ELRNLDLT----------KRKMIHEGPLV 1027
+ +QRL R+D + S V+ E +LDLT R+++ EG L
Sbjct: 533 QERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLR 592
Query: 1028 WKVNRDKTIDLYTLLLEDILVLLQKQDDRLVLRCHSKILASTADSKHTFSPVIKLSTVLV 1087
K +D +D+Y L D+L++ + A+ P + + ++
Sbjct: 593 MKEGKDSKMDVYCFLFTDLLLVTK--------------AVKKAERTRVIRPPLLVDKIVC 638
Query: 1088 RQVATDNKALFVI---SMSDNGAQIYELVAQTVSE---KTVW--QDLICRMAASVKEQST 1139
R++ L + S GA ++ Q + T++ Q+ + ++ A S
Sbjct: 639 RELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQ 698
Query: 1140 KPIPLPQSTPGEGDNDEEDPSKLKEEQHGISVTGLQSPDRDLGLESTLISSKPQSHSLST 1199
+P+ QS E D EE+ + +EE+ G +G + + + S P S ++
Sbjct: 699 QPL---QSLEEEEDEQEEEEEEEEEEEEG-EDSGTSAASSPTIMRKS--SGSPDSQHCAS 752
Query: 1200 SGKSEVRDLFVAE 1212
G +E + V E
Sbjct: 753 DGSTETLAMVVVE 765
>gi|111154080 pleckstrin homology domain containing family G member 5
isoform a [Homo sapiens]
Length = 1006
Score = 145 bits (367), Expect = 2e-34
Identities = 159/673 (23%), Positives = 287/673 (42%), Gaps = 80/673 (11%)
Query: 573 GFLPKIKQSMKKDKEGEEKGKRRGFPSILGPPRRPSRHDNSAIGRAMELQKARHPKHLST 632
G ++K K EG+ + + S+ P RP+ A+ R ++ Q R +
Sbjct: 140 GHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPPALER-VDAQSRRESLDILA 198
Query: 633 PSSVSPEPQDSAKLRQSGLANEGTDAGYLPANSMS-SVASGASFSQEGGK--ENDTGSKQ 689
P + S E + G P S S+ SG+S S G +N S+
Sbjct: 199 PGR--------RRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNTGDSWKNRAASRF 250
Query: 690 VGE-TSAPGDTLDGTPRTLNTVFDFPPPPLDQVQEEECEVERVTEHGTPKPFR--KFDSV 746
G +S P + G +D++++ E ++ + G P+ R +FD
Sbjct: 251 SGFFSSGPSTSAFGRE-------------VDKMEQLEGKLHTYSLFGLPRLPRGLRFDHD 297
Query: 747 AFGESQSEDEQFENDLETDPPNWQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTL 806
++ E EDE +N +W++L+ L + C +QE + EL +TE +++R L
Sbjct: 298 SWEEEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCH--QQEAVWELLHTEASYIRKL 355
Query: 807 KVLDQVFY---QRVSREGILSPSELRKIFSNLEDILQLHIGLNEQMKA--VRKRNETSVI 861
+V+ +F + G+L E ++FSN+ +I QLH L + A + K T +
Sbjct: 356 RVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRAL 415
Query: 862 DQIGEDLLTWFSGPGEEKLKHAAATFCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLC 921
Q G D L F G L +C + +E ++ + + F+ ++ AE +P C
Sbjct: 416 LQPG-DFLKGFKMFGS--LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQC 472
Query: 922 RRLQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPTEREKVKKAADHCRQILNYVNQAVKEA 981
+RL+L D++ QRLTKYPLLL ++ + TE P +E V + +++VN +++
Sbjct: 473 QRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQR 532
Query: 982 ENKQRLEDYQRRLDTSSLKLSEYPNVE----ELRNLDLT----------KRKMIHEGPLV 1027
+ +QRL R+D + S V+ E +LDLT R+++ EG L
Sbjct: 533 QERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLR 592
Query: 1028 WKVNRDKTIDLYTLLLEDILVLLQKQDDRLVLRCHSKILASTADSKHTFSPVIKLSTVLV 1087
K +D +D+Y L D+L++ + A+ P + + ++
Sbjct: 593 MKEGKDSKMDVYCFLFTDLLLVTK--------------AVKKAERTRVIRPPLLVDKIVC 638
Query: 1088 RQVATDNKALFVI---SMSDNGAQIYELVAQTVSE---KTVW--QDLICRMAASVKEQST 1139
R++ L + S GA ++ Q + T++ Q+ + ++ A S
Sbjct: 639 RELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQ 698
Query: 1140 KPIPLPQSTPGEGDNDEEDPSKLKEEQHGISVTGLQSPDRDLGLESTLISSKPQSHSLST 1199
+P+ QS E D EE+ + +EE+ G +G + + + S P S ++
Sbjct: 699 QPL---QSLEEEEDEQEEEEEEEEEEEEG-EDSGTSAASSPTIMRKS--SGSPDSQHCAS 752
Query: 1200 SGKSEVRDLFVAE 1212
G +E + V E
Sbjct: 753 DGSTETLAMVVVE 765
>gi|111154078 pleckstrin homology domain containing family G member 5
isoform c [Homo sapiens]
Length = 1062
Score = 145 bits (367), Expect = 2e-34
Identities = 159/673 (23%), Positives = 287/673 (42%), Gaps = 80/673 (11%)
Query: 573 GFLPKIKQSMKKDKEGEEKGKRRGFPSILGPPRRPSRHDNSAIGRAMELQKARHPKHLST 632
G ++K K EG+ + + S+ P RP+ A+ R ++ Q R +
Sbjct: 196 GHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPPALER-VDAQSRRESLDILA 254
Query: 633 PSSVSPEPQDSAKLRQSGLANEGTDAGYLPANSMS-SVASGASFSQEGGK--ENDTGSKQ 689
P + S E + G P S S+ SG+S S G +N S+
Sbjct: 255 PGR--------RRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNTGDSWKNRAASRF 306
Query: 690 VGE-TSAPGDTLDGTPRTLNTVFDFPPPPLDQVQEEECEVERVTEHGTPKPFR--KFDSV 746
G +S P + G +D++++ E ++ + G P+ R +FD
Sbjct: 307 SGFFSSGPSTSAFGRE-------------VDKMEQLEGKLHTYSLFGLPRLPRGLRFDHD 353
Query: 747 AFGESQSEDEQFENDLETDPPNWQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTL 806
++ E EDE +N +W++L+ L + C +QE + EL +TE +++R L
Sbjct: 354 SWEEEYDEDEDEDNACLRLEDSWRELIDGHEKLTRRQCH--QQEAVWELLHTEASYIRKL 411
Query: 807 KVLDQVFY---QRVSREGILSPSELRKIFSNLEDILQLHIGLNEQMKA--VRKRNETSVI 861
+V+ +F + G+L E ++FSN+ +I QLH L + A + K T +
Sbjct: 412 RVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRAL 471
Query: 862 DQIGEDLLTWFSGPGEEKLKHAAATFCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLC 921
Q G D L F G L +C + +E ++ + + F+ ++ AE +P C
Sbjct: 472 LQPG-DFLKGFKMFGS--LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQC 528
Query: 922 RRLQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPTEREKVKKAADHCRQILNYVNQAVKEA 981
+RL+L D++ QRLTKYPLLL ++ + TE P +E V + +++VN +++
Sbjct: 529 QRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQR 588
Query: 982 ENKQRLEDYQRRLDTSSLKLSEYPNVE----ELRNLDLT----------KRKMIHEGPLV 1027
+ +QRL R+D + S V+ E +LDLT R+++ EG L
Sbjct: 589 QERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLR 648
Query: 1028 WKVNRDKTIDLYTLLLEDILVLLQKQDDRLVLRCHSKILASTADSKHTFSPVIKLSTVLV 1087
K +D +D+Y L D+L++ + A+ P + + ++
Sbjct: 649 MKEGKDSKMDVYCFLFTDLLLVTK--------------AVKKAERTRVIRPPLLVDKIVC 694
Query: 1088 RQVATDNKALFVI---SMSDNGAQIYELVAQTVSE---KTVW--QDLICRMAASVKEQST 1139
R++ L + S GA ++ Q + T++ Q+ + ++ A S
Sbjct: 695 RELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQ 754
Query: 1140 KPIPLPQSTPGEGDNDEEDPSKLKEEQHGISVTGLQSPDRDLGLESTLISSKPQSHSLST 1199
+P+ QS E D EE+ + +EE+ G +G + + + S P S ++
Sbjct: 755 QPL---QSLEEEEDEQEEEEEEEEEEEEG-EDSGTSAASSPTIMRKS--SGSPDSQHCAS 808
Query: 1200 SGKSEVRDLFVAE 1212
G +E + V E
Sbjct: 809 DGSTETLAMVVVE 821
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 127 bits (318), Expect = 1e-28
Identities = 105/368 (28%), Positives = 185/368 (50%), Gaps = 32/368 (8%)
Query: 767 PNWQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPS 826
P+ Q + L ++P E KRQ I+EL TE ++ L+++ +VF +R++ G L+
Sbjct: 1162 PSQQWCADLQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEG 1221
Query: 827 ELRKIFSNLEDILQLHIGLNEQMKAVRKRNETS----VIDQIGEDLLTWFSGPGEEKLKH 882
E+ IF N ++++ + L +KA+R R +T + IG+ L +L H
Sbjct: 1222 EMALIFVNWKELIMSNTKL---LKALRVRKKTGGEKMPVQMIGDILAA--------ELSH 1270
Query: 883 AAA--TFCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKY 940
A FCS Q +++ + +D+ F+ F++ S+P C+ + L + MQR+T+Y
Sbjct: 1271 MQAYIRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRY 1330
Query: 941 PLLLDNIAKYT-EWPTEREKVKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSSL 999
PLL+ +I + T E + +K A + ++ + VN+ V+E EN RLE Q +
Sbjct: 1331 PLLIRSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEG- 1389
Query: 1000 KLSEYPNVEELRNLDLTKRKMIHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDDRLVL 1059
L+E L N L RK++H G L +K +K +L+ L D L+L V
Sbjct: 1390 -LAEQLIFNSLTNC-LGPRKLLHSGKL-YKTKSNK--ELHGFLFNDFLLLTYMVKQFAVS 1444
Query: 1060 RCHSKILASTADSK-HTFSPVIKLSTVLVRQVATD---NKALFVISMSDNGAQIYELVAQ 1115
K+ +S ++++ + I L+ VLV+ + TD ++ +F IS D ++Y L
Sbjct: 1445 SGSEKLFSSKSNAQFKMYKTPIFLNEVLVK-LPTDPSSDEPVFHISHID---RVYTLRTD 1500
Query: 1116 TVSEKTVW 1123
++E+T W
Sbjct: 1501 NINERTAW 1508
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 127 bits (318), Expect = 1e-28
Identities = 105/368 (28%), Positives = 185/368 (50%), Gaps = 32/368 (8%)
Query: 767 PNWQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPS 826
P+ Q + L ++P E KRQ I+EL TE ++ L+++ +VF +R++ G L+
Sbjct: 1189 PSQQWCADLQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEG 1248
Query: 827 ELRKIFSNLEDILQLHIGLNEQMKAVRKRNETS----VIDQIGEDLLTWFSGPGEEKLKH 882
E+ IF N ++++ + L +KA+R R +T + IG+ L +L H
Sbjct: 1249 EMALIFVNWKELIMSNTKL---LKALRVRKKTGGEKMPVQMIGDILAA--------ELSH 1297
Query: 883 AAA--TFCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKY 940
A FCS Q +++ + +D+ F+ F++ S+P C+ + L + MQR+T+Y
Sbjct: 1298 MQAYIRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRY 1357
Query: 941 PLLLDNIAKYT-EWPTEREKVKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSSL 999
PLL+ +I + T E + +K A + ++ + VN+ V+E EN RLE Q +
Sbjct: 1358 PLLIRSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEG- 1416
Query: 1000 KLSEYPNVEELRNLDLTKRKMIHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDDRLVL 1059
L+E L N L RK++H G L +K +K +L+ L D L+L V
Sbjct: 1417 -LAEQLIFNSLTNC-LGPRKLLHSGKL-YKTKSNK--ELHGFLFNDFLLLTYMVKQFAVS 1471
Query: 1060 RCHSKILASTADSK-HTFSPVIKLSTVLVRQVATD---NKALFVISMSDNGAQIYELVAQ 1115
K+ +S ++++ + I L+ VLV+ + TD ++ +F IS D ++Y L
Sbjct: 1472 SGSEKLFSSKSNAQFKMYKTPIFLNEVLVK-LPTDPSSDEPVFHISHID---RVYTLRTD 1527
Query: 1116 TVSEKTVW 1123
++E+T W
Sbjct: 1528 NINERTAW 1535
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 119 bits (299), Expect = 2e-26
Identities = 125/483 (25%), Positives = 217/483 (44%), Gaps = 64/483 (13%)
Query: 659 GYLPANSMSSVASGASFSQEGGKENDTGSKQVGETSAPGDTLDGTPRTLNTVFDFPPPPL 718
G+ PAN + ++ G S ++ T P T + ++D+
Sbjct: 1126 GWFPANYVKLLSPGTS--------------KITPTEPPKSTALAAVCQVIGMYDYTAQND 1171
Query: 719 DQVQEEECEVERVTEHGTPKPFRKFDSVAFGESQSEDEQFENDLETDPPNWQQLVSREVL 778
D++ + ++ V P ++ + G S + D++ P+ Q +L
Sbjct: 1172 DELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMD---PSQQWCSDLHLL 1228
Query: 779 LGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSELRKIFSNLEDI 838
L P E KRQ I+EL TE +V L+++ ++F + + +L+ E+ IF N +++
Sbjct: 1229 DMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWKEL 1288
Query: 839 LQLHIGLNEQMKAVRKRN-ETSVIDQIGEDLLTWFSGPGEEKLKHAAA--TFCSNQPFAL 895
+ +I L + ++ +K + E + IG+ L +L H FCS Q
Sbjct: 1289 IMCNIKLLKALRVRKKMSGEKMPVKMIGDIL--------SAQLPHMQPYIRFCSRQLNGA 1340
Query: 896 EMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYT-EWP 954
+I+ + + F+ FV+ +P C+ + L I MQR+T+YPL++ NI + T E
Sbjct: 1341 ALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENH 1400
Query: 955 TEREKVKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSSLKLSEYPNVEELRNLD 1014
+ +K A + ++ + VN+ V+E EN RLE Q + LSE + N
Sbjct: 1401 PDHSHLKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEG--LSEQLVFNSVTNC- 1457
Query: 1015 LTKRKMIHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDDRLVLRCHSKILASTADSKH 1074
L RK +H G L +K +K +LY L D L+L Q +K L S+ K
Sbjct: 1458 LGPRKFLHSGKL-YKAKSNK--ELYGFLFNDFLLLTQ----------ITKPLGSSGTDK- 1503
Query: 1075 TFSP-----------VIKLSTVLVRQVATD---NKALFVISMSDNGAQIYELVAQTVSEK 1120
FSP I L+ VLV+ + TD ++ +F IS D ++Y L A++++E+
Sbjct: 1504 VFSPKSNLQYKMYKTPIFLNEVLVK-LPTDPSGDEPIFHISHID---RVYTLRAESINER 1559
Query: 1121 TVW 1123
T W
Sbjct: 1560 TAW 1562
>gi|114145479 neuroepithelial cell transforming gene 1 isoform 1 [Homo
sapiens]
Length = 596
Score = 88.6 bits (218), Expect = 4e-17
Identities = 78/281 (27%), Positives = 129/281 (45%), Gaps = 24/281 (8%)
Query: 769 WQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSEL 828
W +++ + L EI+RQE I E+ E+ + LK+ + ++ + + I+S EL
Sbjct: 156 WSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEEL 215
Query: 829 RKIFSNLEDILQLHIGLNEQMKAVRKRNETSVIDQIGEDLLTWFSGPGEEKLKHAAATFC 888
IF +L+ + LH L ++ K + T ++QIG L++W +A +C
Sbjct: 216 THIFGDLDSYIPLHEDLLTRIGEATKPDGT--VEQIGHILVSWLPR------LNAYRGYC 267
Query: 889 SNQPFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIA 948
SNQ A + + ++K+D R Q F+Q +P R+L L + RL KYPLLL I
Sbjct: 268 SNQ-LAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEIL 326
Query: 949 KYTEWPTEREKVKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSSLKLSEYPNVE 1008
K+T P E V+ D I+ V + + + + Y +L+ K + P +E
Sbjct: 327 KHT--PKEHPDVQLLED-AILIIQGVLSDINLKKGESECQYYIDKLEYLDEKQRD-PRIE 382
Query: 1009 ELRNLDLTKRKMIHEGPLVWKVNRDKTIDLYTLLLEDILVL 1049
+ ++ G L K LY L +DILVL
Sbjct: 383 -------ASKVLLCHGELRSKSGH----KLYIFLFQDILVL 412
>gi|19923327 neuroepithelial cell transforming gene 1 isoform 2 [Homo
sapiens]
Length = 542
Score = 88.6 bits (218), Expect = 4e-17
Identities = 78/281 (27%), Positives = 129/281 (45%), Gaps = 24/281 (8%)
Query: 769 WQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSEL 828
W +++ + L EI+RQE I E+ E+ + LK+ + ++ + + I+S EL
Sbjct: 102 WSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEEL 161
Query: 829 RKIFSNLEDILQLHIGLNEQMKAVRKRNETSVIDQIGEDLLTWFSGPGEEKLKHAAATFC 888
IF +L+ + LH L ++ K + T ++QIG L++W +A +C
Sbjct: 162 THIFGDLDSYIPLHEDLLTRIGEATKPDGT--VEQIGHILVSWLPR------LNAYRGYC 213
Query: 889 SNQPFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIA 948
SNQ A + + ++K+D R Q F+Q +P R+L L + RL KYPLLL I
Sbjct: 214 SNQ-LAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEIL 272
Query: 949 KYTEWPTEREKVKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSSLKLSEYPNVE 1008
K+T P E V+ D I+ V + + + + Y +L+ K + P +E
Sbjct: 273 KHT--PKEHPDVQLLED-AILIIQGVLSDINLKKGESECQYYIDKLEYLDEKQRD-PRIE 328
Query: 1009 ELRNLDLTKRKMIHEGPLVWKVNRDKTIDLYTLLLEDILVL 1049
+ ++ G L K LY L +DILVL
Sbjct: 329 -------ASKVLLCHGELRSKSGH----KLYIFLFQDILVL 358
>gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2 [Homo
sapiens]
Length = 532
Score = 88.2 bits (217), Expect = 6e-17
Identities = 78/280 (27%), Positives = 137/280 (48%), Gaps = 28/280 (10%)
Query: 785 EIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSELRKIFSNLEDILQLHIG 844
EIKRQE I EL E + LK+ + ++ + + I++ EL +IF L+ ++ LH
Sbjct: 126 EIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEE 185
Query: 845 LNEQMKAVRKRNETSVIDQIGEDLLTWFSGPGEEKLKHAAATFCSNQPFALEMIKSRQKK 904
L Q++ VRK + ++ + +G L+ W + ++CSNQ A + + +K+
Sbjct: 186 LLSQLRDVRKPDGST--EHVGPILVGWL------PCLSSYDSYCSNQ-VAAKALLDHKKQ 236
Query: 905 DSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPT-EREKVKKA 963
D R Q F+Q +P R+L L + + RL KYPLLL I ++T +++ +++A
Sbjct: 237 DHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEA 296
Query: 964 ADHCRQILNYVNQAVKEAE---NKQRL----EDYQRRLDTSSLKLSEYPNVEELRNLDL- 1015
+ + I+ +N E+E K+RL E + L SS L + ++ R + L
Sbjct: 297 INIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLH 356
Query: 1016 ---------TKRKMIHEGPLVWKVNRDKTIDLYTLLLEDI 1046
R + H L +++ R + I + LLLED+
Sbjct: 357 VFLFQEVLVITRAVTHNEQLCYQLYR-QPIPVKDLLLEDL 395
>gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1 [Homo
sapiens]
Length = 558
Score = 88.2 bits (217), Expect = 6e-17
Identities = 78/280 (27%), Positives = 137/280 (48%), Gaps = 28/280 (10%)
Query: 785 EIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSELRKIFSNLEDILQLHIG 844
EIKRQE I EL E + LK+ + ++ + + I++ EL +IF L+ ++ LH
Sbjct: 152 EIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEE 211
Query: 845 LNEQMKAVRKRNETSVIDQIGEDLLTWFSGPGEEKLKHAAATFCSNQPFALEMIKSRQKK 904
L Q++ VRK + ++ + +G L+ W + ++CSNQ A + + +K+
Sbjct: 212 LLSQLRDVRKPDGST--EHVGPILVGWL------PCLSSYDSYCSNQ-VAAKALLDHKKQ 262
Query: 905 DSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPT-EREKVKKA 963
D R Q F+Q +P R+L L + + RL KYPLLL I ++T +++ +++A
Sbjct: 263 DHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEA 322
Query: 964 ADHCRQILNYVNQAVKEAE---NKQRL----EDYQRRLDTSSLKLSEYPNVEELRNLDL- 1015
+ + I+ +N E+E K+RL E + L SS L + ++ R + L
Sbjct: 323 INIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLH 382
Query: 1016 ---------TKRKMIHEGPLVWKVNRDKTIDLYTLLLEDI 1046
R + H L +++ R + I + LLLED+
Sbjct: 383 VFLFQEVLVITRAVTHNEQLCYQLYR-QPIPVKDLLLEDL 421
>gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [Homo
sapiens]
Length = 526
Score = 88.2 bits (217), Expect = 6e-17
Identities = 78/280 (27%), Positives = 137/280 (48%), Gaps = 28/280 (10%)
Query: 785 EIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSELRKIFSNLEDILQLHIG 844
EIKRQE I EL E + LK+ + ++ + + I++ EL +IF L+ ++ LH
Sbjct: 120 EIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEE 179
Query: 845 LNEQMKAVRKRNETSVIDQIGEDLLTWFSGPGEEKLKHAAATFCSNQPFALEMIKSRQKK 904
L Q++ VRK + ++ + +G L+ W + ++CSNQ A + + +K+
Sbjct: 180 LLSQLRDVRKPDGST--EHVGPILVGWL------PCLSSYDSYCSNQ-VAAKALLDHKKQ 230
Query: 905 DSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPT-EREKVKKA 963
D R Q F+Q +P R+L L + + RL KYPLLL I ++T +++ +++A
Sbjct: 231 DHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEA 290
Query: 964 ADHCRQILNYVNQAVKEAE---NKQRL----EDYQRRLDTSSLKLSEYPNVEELRNLDL- 1015
+ + I+ +N E+E K+RL E + L SS L + ++ R + L
Sbjct: 291 INIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLH 350
Query: 1016 ---------TKRKMIHEGPLVWKVNRDKTIDLYTLLLEDI 1046
R + H L +++ R + I + LLLED+
Sbjct: 351 VFLFQEVLVITRAVTHNEQLCYQLYR-QPIPVKDLLLEDL 389
>gi|222080070 pleckstrin homology domain-containing family G member 6
isoform b [Homo sapiens]
Length = 758
Score = 85.5 bits (210), Expect = 4e-16
Identities = 75/308 (24%), Positives = 137/308 (44%), Gaps = 30/308 (9%)
Query: 768 NWQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQ---RVSREGILS 824
+W++LV + + C +QE + EL TE +VR LK++ + + R G+L
Sbjct: 112 SWRELVPGHKEMSQELCH--QQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLM 169
Query: 825 PSELRKIFSNLEDILQLHIGLNEQMKAV---RKRNETSVIDQIGEDLLTWFSGPGEEKLK 881
+F N+ +++ H +++ R +D IG L + F G+
Sbjct: 170 EVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIG--LQSGFLTFGQRF-- 225
Query: 882 HAAATFCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYP 941
H +C + + +Q+ + F FVQ E + R L D++ QR+TKYP
Sbjct: 226 HPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYP 285
Query: 942 LLLDNIAKYTEWPTEREKVKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSSLKL 1001
LLL + K + +E + + L ++N V++ E ++ L +R+ ++
Sbjct: 286 LLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRI--GPYEV 343
Query: 1002 SEYPNVEELRN------LDLTK----------RKMIHEGPLVWKVNRDKTIDLYTLLLED 1045
E P+ E +N LDLT R+++ EGP+ K R+ +D+Y L D
Sbjct: 344 LEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSD 403
Query: 1046 ILVLLQKQ 1053
+L++ + Q
Sbjct: 404 VLLVTKPQ 411
>gi|222080068 pleckstrin homology domain-containing family G member 6
isoform a [Homo sapiens]
Length = 790
Score = 85.5 bits (210), Expect = 4e-16
Identities = 75/308 (24%), Positives = 137/308 (44%), Gaps = 30/308 (9%)
Query: 768 NWQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQ---RVSREGILS 824
+W++LV + + C +QE + EL TE +VR LK++ + + R G+L
Sbjct: 144 SWRELVPGHKEMSQELCH--QQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLM 201
Query: 825 PSELRKIFSNLEDILQLHIGLNEQMKAV---RKRNETSVIDQIGEDLLTWFSGPGEEKLK 881
+F N+ +++ H +++ R +D IG L + F G+
Sbjct: 202 EVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIG--LQSGFLTFGQRF-- 257
Query: 882 HAAATFCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYP 941
H +C + + +Q+ + F FVQ E + R L D++ QR+TKYP
Sbjct: 258 HPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYP 317
Query: 942 LLLDNIAKYTEWPTEREKVKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSSLKL 1001
LLL + K + +E + + L ++N V++ E ++ L +R+ ++
Sbjct: 318 LLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRI--GPYEV 375
Query: 1002 SEYPNVEELRN------LDLTK----------RKMIHEGPLVWKVNRDKTIDLYTLLLED 1045
E P+ E +N LDLT R+++ EGP+ K R+ +D+Y L D
Sbjct: 376 LEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSD 435
Query: 1046 ILVLLQKQ 1053
+L++ + Q
Sbjct: 436 VLLVTKPQ 443
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.130 0.366
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 62,150,361
Number of Sequences: 37866
Number of extensions: 3095950
Number of successful extensions: 11471
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 136
Number of HSP's successfully gapped in prelim test: 237
Number of HSP's that attempted gapping in prelim test: 10623
Number of HSP's gapped (non-prelim): 989
length of query: 1544
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1429
effective length of database: 13,892,928
effective search space: 19852994112
effective search space used: 19852994112
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.