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Search of human proteins with 7662086
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11
isoform 1 [Homo sapiens]
(1522 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo... 3041 0.0
gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof... 3022 0.0
gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo... 660 0.0
gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [... 447 e-125
gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [... 447 e-125
gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [... 413 e-115
gi|195972857 Rho/Rac guanine nucleotide exchange factor 18 isofo... 190 1e-47
gi|41327769 Rho/Rac guanine nucleotide exchange factor 18 isofor... 189 2e-47
gi|253735778 Rho/Rac guanine nucleotide exchange factor 2 isofor... 185 3e-46
gi|15011974 Rho/Rac guanine nucleotide exchange factor 2 isoofor... 185 3e-46
gi|253735775 Rho/Rac guanine nucleotide exchange factor 2 isofor... 184 4e-46
gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens] 178 4e-44
gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens] 178 4e-44
gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens] 178 4e-44
gi|122937434 Rho-guanine nucleotide exchange factor [Homo sapiens] 169 2e-41
gi|38373682 pleckstrin homology domain containing family G membe... 132 3e-30
gi|111154084 pleckstrin homology domain containing family G memb... 132 3e-30
gi|111154088 pleckstrin homology domain containing family G memb... 132 3e-30
gi|111154080 pleckstrin homology domain containing family G memb... 132 3e-30
gi|111154078 pleckstrin homology domain containing family G memb... 132 3e-30
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 122 3e-27
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 120 1e-26
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 120 1e-26
gi|222080070 pleckstrin homology domain-containing family G memb... 96 2e-19
gi|222080068 pleckstrin homology domain-containing family G memb... 96 2e-19
gi|222080066 pleckstrin homology domain-containing family G memb... 96 2e-19
gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2 ... 91 9e-18
gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1 ... 89 3e-17
gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [H... 89 3e-17
gi|21735572 epithelial cell transforming sequence 2 oncogene pro... 86 4e-16
>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform 1
[Homo sapiens]
Length = 1522
Score = 3041 bits (7885), Expect = 0.0
Identities = 1522/1522 (100%), Positives = 1522/1522 (100%)
Query: 1 MSVRLPQSIDRLSSLSSLGDSAPERKSPSHHRQPSDASETTGLVQRCVIIQKDQHGFGFT 60
MSVRLPQSIDRLSSLSSLGDSAPERKSPSHHRQPSDASETTGLVQRCVIIQKDQHGFGFT
Sbjct: 1 MSVRLPQSIDRLSSLSSLGDSAPERKSPSHHRQPSDASETTGLVQRCVIIQKDQHGFGFT 60
Query: 61 VSGDRIVLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNSSHLEVVKLIKSGAYVALTLL 120
VSGDRIVLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNSSHLEVVKLIKSGAYVALTLL
Sbjct: 61 VSGDRIVLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNSSHLEVVKLIKSGAYVALTLL 120
Query: 121 GSSPSSMGISGLQQDPSPAGAPRITSVIPSPPPPPPLPPPQRITGPKPLQDPEVQKHATQ 180
GSSPSSMGISGLQQDPSPAGAPRITSVIPSPPPPPPLPPPQRITGPKPLQDPEVQKHATQ
Sbjct: 121 GSSPSSMGISGLQQDPSPAGAPRITSVIPSPPPPPPLPPPQRITGPKPLQDPEVQKHATQ 180
Query: 181 ILRNMLRQEEKELQDILPLYGDTSQRPSEGRLSLDSQEGDSGLDSGTERFPSLSESLMNR 240
ILRNMLRQEEKELQDILPLYGDTSQRPSEGRLSLDSQEGDSGLDSGTERFPSLSESLMNR
Sbjct: 181 ILRNMLRQEEKELQDILPLYGDTSQRPSEGRLSLDSQEGDSGLDSGTERFPSLSESLMNR 240
Query: 241 NSVLSDPGLDSPRTSPVIMARVAQHHRRQGSDAAVPSTGDQGVDQSPKPLIIGPEEDYDP 300
NSVLSDPGLDSPRTSPVIMARVAQHHRRQGSDAAVPSTGDQGVDQSPKPLIIGPEEDYDP
Sbjct: 241 NSVLSDPGLDSPRTSPVIMARVAQHHRRQGSDAAVPSTGDQGVDQSPKPLIIGPEEDYDP 300
Query: 301 GYFNNESDIIFQDLEKLKSRPAHLGVFLRYIFSQADPSPLLFYLCAEVYQQASPKDSRSL 360
GYFNNESDIIFQDLEKLKSRPAHLGVFLRYIFSQADPSPLLFYLCAEVYQQASPKDSRSL
Sbjct: 301 GYFNNESDIIFQDLEKLKSRPAHLGVFLRYIFSQADPSPLLFYLCAEVYQQASPKDSRSL 360
Query: 361 GKDIWNIFLEKNAPLRVKIPEMLQAEIDSRLRNSEDARGVLCEAQEAAMPEIQEQIHDYR 420
GKDIWNIFLEKNAPLRVKIPEMLQAEIDSRLRNSEDARGVLCEAQEAAMPEIQEQIHDYR
Sbjct: 361 GKDIWNIFLEKNAPLRVKIPEMLQAEIDSRLRNSEDARGVLCEAQEAAMPEIQEQIHDYR 420
Query: 421 TKRTLGLGSLYGENDLLDLDGDPLRERQVAEKQLAALGDILSKYEEDRSAPMDFALNTYM 480
TKRTLGLGSLYGENDLLDLDGDPLRERQVAEKQLAALGDILSKYEEDRSAPMDFALNTYM
Sbjct: 421 TKRTLGLGSLYGENDLLDLDGDPLRERQVAEKQLAALGDILSKYEEDRSAPMDFALNTYM 480
Query: 481 SHAGIRLREARPSNTAEKAQSAPDKDKWLPFFPKTKKSSNSKKEKDALEDKKRNPILKYI 540
SHAGIRLREARPSNTAEKAQSAPDKDKWLPFFPKTKKSSNSKKEKDALEDKKRNPILKYI
Sbjct: 481 SHAGIRLREARPSNTAEKAQSAPDKDKWLPFFPKTKKSSNSKKEKDALEDKKRNPILKYI 540
Query: 541 GKPKSSSQSTFHIPLSPVEVKPGNVRNIIQHFENNQQYDAPEPGTQRLSTGSFPEDLLES 600
GKPKSSSQSTFHIPLSPVEVKPGNVRNIIQHFENNQQYDAPEPGTQRLSTGSFPEDLLES
Sbjct: 541 GKPKSSSQSTFHIPLSPVEVKPGNVRNIIQHFENNQQYDAPEPGTQRLSTGSFPEDLLES 600
Query: 601 DSSRSEIRLGRSESLKGREEMKRSRKAENVPRSRSDVDMDAAAEATRLHQSASSSTSSLS 660
DSSRSEIRLGRSESLKGREEMKRSRKAENVPRSRSDVDMDAAAEATRLHQSASSSTSSLS
Sbjct: 601 DSSRSEIRLGRSESLKGREEMKRSRKAENVPRSRSDVDMDAAAEATRLHQSASSSTSSLS 660
Query: 661 TRSLENPTPPFTPKMGRRSIESPSLGFCTDTLLPHLLEDDLGQLSDLEPEPDAQNWQHTV 720
TRSLENPTPPFTPKMGRRSIESPSLGFCTDTLLPHLLEDDLGQLSDLEPEPDAQNWQHTV
Sbjct: 661 TRSLENPTPPFTPKMGRRSIESPSLGFCTDTLLPHLLEDDLGQLSDLEPEPDAQNWQHTV 720
Query: 721 GKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFP 780
GKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFP
Sbjct: 721 GKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFP 780
Query: 781 NLPELIEIHNSWCEAMKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIAL 840
NLPELIEIHNSWCEAMKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIAL
Sbjct: 781 NLPELIEIHNSWCEAMKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIAL 840
Query: 841 ELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGT 900
ELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGT
Sbjct: 841 ELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGT 900
Query: 901 SEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLD 960
SEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLD
Sbjct: 901 SEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLD 960
Query: 961 LTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQ 1020
LTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQ
Sbjct: 961 LTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQ 1020
Query: 1021 TFSPVLKLNAVLIRSVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRN 1080
TFSPVLKLNAVLIRSVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRN
Sbjct: 1021 TFSPVLKLNAVLIRSVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRN 1080
Query: 1081 ATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEPEPEELPGGTGSQQRVQ 1140
ATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEPEPEELPGGTGSQQRVQ
Sbjct: 1081 ATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEPEPEELPGGTGSQQRVQ 1140
Query: 1141 GKHQVLLEDPEQEGSAEEEELGVLPCPSTSLDGENRGIRTRNPIHLAFPGPLFMEGLADS 1200
GKHQVLLEDPEQEGSAEEEELGVLPCPSTSLDGENRGIRTRNPIHLAFPGPLFMEGLADS
Sbjct: 1141 GKHQVLLEDPEQEGSAEEEELGVLPCPSTSLDGENRGIRTRNPIHLAFPGPLFMEGLADS 1200
Query: 1201 ALEDVENLRHLILWSLLPGHTMETQAAQEPEDDLTPTPSVISVTSHPWDPGSPGQAPPGG 1260
ALEDVENLRHLILWSLLPGHTMETQAAQEPEDDLTPTPSVISVTSHPWDPGSPGQAPPGG
Sbjct: 1201 ALEDVENLRHLILWSLLPGHTMETQAAQEPEDDLTPTPSVISVTSHPWDPGSPGQAPPGG 1260
Query: 1261 EGDNTQLAGLEGERPEQEDMGLCSLEHLPPRTRNSGIWESPELDRNLAEDASSTEAAGGY 1320
EGDNTQLAGLEGERPEQEDMGLCSLEHLPPRTRNSGIWESPELDRNLAEDASSTEAAGGY
Sbjct: 1261 EGDNTQLAGLEGERPEQEDMGLCSLEHLPPRTRNSGIWESPELDRNLAEDASSTEAAGGY 1320
Query: 1321 KVVRKAEVAGSKVVPALPESGQSEPGPPEVEGGTKATGNCFYVSMPSGPPDSSTDHSEAP 1380
KVVRKAEVAGSKVVPALPESGQSEPGPPEVEGGTKATGNCFYVSMPSGPPDSSTDHSEAP
Sbjct: 1321 KVVRKAEVAGSKVVPALPESGQSEPGPPEVEGGTKATGNCFYVSMPSGPPDSSTDHSEAP 1380
Query: 1381 MSPPQPDSLPAGQTEPQPQLQGGNDDPRRPSRSPPSLALRDVGMIFHTIEQLTLKLNRLK 1440
MSPPQPDSLPAGQTEPQPQLQGGNDDPRRPSRSPPSLALRDVGMIFHTIEQLTLKLNRLK
Sbjct: 1381 MSPPQPDSLPAGQTEPQPQLQGGNDDPRRPSRSPPSLALRDVGMIFHTIEQLTLKLNRLK 1440
Query: 1441 DMELAHRELLKSLGGESSGGTTPVGSFHTEAARWTDGSLSPPAKEPLASDSRNSHELGPC 1500
DMELAHRELLKSLGGESSGGTTPVGSFHTEAARWTDGSLSPPAKEPLASDSRNSHELGPC
Sbjct: 1441 DMELAHRELLKSLGGESSGGTTPVGSFHTEAARWTDGSLSPPAKEPLASDSRNSHELGPC 1500
Query: 1501 PEDGSDAPLEDSTADAAASPGP 1522
PEDGSDAPLEDSTADAAASPGP
Sbjct: 1501 PEDGSDAPLEDSTADAAASPGP 1522
>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform 2
[Homo sapiens]
Length = 1562
Score = 3022 bits (7834), Expect = 0.0
Identities = 1522/1562 (97%), Positives = 1522/1562 (97%), Gaps = 40/1562 (2%)
Query: 1 MSVRLPQSIDRLSSLSSLGDSAPERKSPSHHRQPSDASETTGLVQRCVIIQKDQHGFGFT 60
MSVRLPQSIDRLSSLSSLGDSAPERKSPSHHRQPSDASETTGLVQRCVIIQKDQHGFGFT
Sbjct: 1 MSVRLPQSIDRLSSLSSLGDSAPERKSPSHHRQPSDASETTGLVQRCVIIQKDQHGFGFT 60
Query: 61 VSGDRIVLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNSSHLEVVKLIKSGAYVALTLL 120
VSGDRIVLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNSSHLEVVKLIKSGAYVALTLL
Sbjct: 61 VSGDRIVLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNSSHLEVVKLIKSGAYVALTLL 120
Query: 121 GSSPSSMGISGLQQDPSPAGAPRITSVIPSPPPPPPLPPPQRITGPKPLQDPEVQKHATQ 180
GSSPSSMGISGLQQDPSPAGAPRITSVIPSPPPPPPLPPPQRITGPKPLQDPEVQKHATQ
Sbjct: 121 GSSPSSMGISGLQQDPSPAGAPRITSVIPSPPPPPPLPPPQRITGPKPLQDPEVQKHATQ 180
Query: 181 ILRNMLRQEEKELQ----------------------------------------DILPLY 200
ILRNMLRQEEKELQ DILPLY
Sbjct: 181 ILRNMLRQEEKELQRICEVYSRNPASLLEEQIEGARRRVTQLQLKIQQETGGSVDILPLY 240
Query: 201 GDTSQRPSEGRLSLDSQEGDSGLDSGTERFPSLSESLMNRNSVLSDPGLDSPRTSPVIMA 260
GDTSQRPSEGRLSLDSQEGDSGLDSGTERFPSLSESLMNRNSVLSDPGLDSPRTSPVIMA
Sbjct: 241 GDTSQRPSEGRLSLDSQEGDSGLDSGTERFPSLSESLMNRNSVLSDPGLDSPRTSPVIMA 300
Query: 261 RVAQHHRRQGSDAAVPSTGDQGVDQSPKPLIIGPEEDYDPGYFNNESDIIFQDLEKLKSR 320
RVAQHHRRQGSDAAVPSTGDQGVDQSPKPLIIGPEEDYDPGYFNNESDIIFQDLEKLKSR
Sbjct: 301 RVAQHHRRQGSDAAVPSTGDQGVDQSPKPLIIGPEEDYDPGYFNNESDIIFQDLEKLKSR 360
Query: 321 PAHLGVFLRYIFSQADPSPLLFYLCAEVYQQASPKDSRSLGKDIWNIFLEKNAPLRVKIP 380
PAHLGVFLRYIFSQADPSPLLFYLCAEVYQQASPKDSRSLGKDIWNIFLEKNAPLRVKIP
Sbjct: 361 PAHLGVFLRYIFSQADPSPLLFYLCAEVYQQASPKDSRSLGKDIWNIFLEKNAPLRVKIP 420
Query: 381 EMLQAEIDSRLRNSEDARGVLCEAQEAAMPEIQEQIHDYRTKRTLGLGSLYGENDLLDLD 440
EMLQAEIDSRLRNSEDARGVLCEAQEAAMPEIQEQIHDYRTKRTLGLGSLYGENDLLDLD
Sbjct: 421 EMLQAEIDSRLRNSEDARGVLCEAQEAAMPEIQEQIHDYRTKRTLGLGSLYGENDLLDLD 480
Query: 441 GDPLRERQVAEKQLAALGDILSKYEEDRSAPMDFALNTYMSHAGIRLREARPSNTAEKAQ 500
GDPLRERQVAEKQLAALGDILSKYEEDRSAPMDFALNTYMSHAGIRLREARPSNTAEKAQ
Sbjct: 481 GDPLRERQVAEKQLAALGDILSKYEEDRSAPMDFALNTYMSHAGIRLREARPSNTAEKAQ 540
Query: 501 SAPDKDKWLPFFPKTKKSSNSKKEKDALEDKKRNPILKYIGKPKSSSQSTFHIPLSPVEV 560
SAPDKDKWLPFFPKTKKSSNSKKEKDALEDKKRNPILKYIGKPKSSSQSTFHIPLSPVEV
Sbjct: 541 SAPDKDKWLPFFPKTKKSSNSKKEKDALEDKKRNPILKYIGKPKSSSQSTFHIPLSPVEV 600
Query: 561 KPGNVRNIIQHFENNQQYDAPEPGTQRLSTGSFPEDLLESDSSRSEIRLGRSESLKGREE 620
KPGNVRNIIQHFENNQQYDAPEPGTQRLSTGSFPEDLLESDSSRSEIRLGRSESLKGREE
Sbjct: 601 KPGNVRNIIQHFENNQQYDAPEPGTQRLSTGSFPEDLLESDSSRSEIRLGRSESLKGREE 660
Query: 621 MKRSRKAENVPRSRSDVDMDAAAEATRLHQSASSSTSSLSTRSLENPTPPFTPKMGRRSI 680
MKRSRKAENVPRSRSDVDMDAAAEATRLHQSASSSTSSLSTRSLENPTPPFTPKMGRRSI
Sbjct: 661 MKRSRKAENVPRSRSDVDMDAAAEATRLHQSASSSTSSLSTRSLENPTPPFTPKMGRRSI 720
Query: 681 ESPSLGFCTDTLLPHLLEDDLGQLSDLEPEPDAQNWQHTVGKDVVAGLTQREIDRQEVIN 740
ESPSLGFCTDTLLPHLLEDDLGQLSDLEPEPDAQNWQHTVGKDVVAGLTQREIDRQEVIN
Sbjct: 721 ESPSLGFCTDTLLPHLLEDDLGQLSDLEPEPDAQNWQHTVGKDVVAGLTQREIDRQEVIN 780
Query: 741 ELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEAMKKLR 800
ELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEAMKKLR
Sbjct: 781 ELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEAMKKLR 840
Query: 801 EEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEA 860
EEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEA
Sbjct: 841 EEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEA 900
Query: 861 ESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYV 920
ESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYV
Sbjct: 901 ESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYV 960
Query: 921 NEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIHEGPLTWRISKDK 980
NEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIHEGPLTWRISKDK
Sbjct: 961 NEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIHEGPLTWRISKDK 1020
Query: 981 TLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDK 1040
TLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDK
Sbjct: 1021 TLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDK 1080
Query: 1041 RAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRNATRHPGAAPMPVHPPPPGPR 1100
RAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRNATRHPGAAPMPVHPPPPGPR
Sbjct: 1081 RAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRNATRHPGAAPMPVHPPPPGPR 1140
Query: 1101 EPAQQGPTPSRVELDDSDVFHGEPEPEELPGGTGSQQRVQGKHQVLLEDPEQEGSAEEEE 1160
EPAQQGPTPSRVELDDSDVFHGEPEPEELPGGTGSQQRVQGKHQVLLEDPEQEGSAEEEE
Sbjct: 1141 EPAQQGPTPSRVELDDSDVFHGEPEPEELPGGTGSQQRVQGKHQVLLEDPEQEGSAEEEE 1200
Query: 1161 LGVLPCPSTSLDGENRGIRTRNPIHLAFPGPLFMEGLADSALEDVENLRHLILWSLLPGH 1220
LGVLPCPSTSLDGENRGIRTRNPIHLAFPGPLFMEGLADSALEDVENLRHLILWSLLPGH
Sbjct: 1201 LGVLPCPSTSLDGENRGIRTRNPIHLAFPGPLFMEGLADSALEDVENLRHLILWSLLPGH 1260
Query: 1221 TMETQAAQEPEDDLTPTPSVISVTSHPWDPGSPGQAPPGGEGDNTQLAGLEGERPEQEDM 1280
TMETQAAQEPEDDLTPTPSVISVTSHPWDPGSPGQAPPGGEGDNTQLAGLEGERPEQEDM
Sbjct: 1261 TMETQAAQEPEDDLTPTPSVISVTSHPWDPGSPGQAPPGGEGDNTQLAGLEGERPEQEDM 1320
Query: 1281 GLCSLEHLPPRTRNSGIWESPELDRNLAEDASSTEAAGGYKVVRKAEVAGSKVVPALPES 1340
GLCSLEHLPPRTRNSGIWESPELDRNLAEDASSTEAAGGYKVVRKAEVAGSKVVPALPES
Sbjct: 1321 GLCSLEHLPPRTRNSGIWESPELDRNLAEDASSTEAAGGYKVVRKAEVAGSKVVPALPES 1380
Query: 1341 GQSEPGPPEVEGGTKATGNCFYVSMPSGPPDSSTDHSEAPMSPPQPDSLPAGQTEPQPQL 1400
GQSEPGPPEVEGGTKATGNCFYVSMPSGPPDSSTDHSEAPMSPPQPDSLPAGQTEPQPQL
Sbjct: 1381 GQSEPGPPEVEGGTKATGNCFYVSMPSGPPDSSTDHSEAPMSPPQPDSLPAGQTEPQPQL 1440
Query: 1401 QGGNDDPRRPSRSPPSLALRDVGMIFHTIEQLTLKLNRLKDMELAHRELLKSLGGESSGG 1460
QGGNDDPRRPSRSPPSLALRDVGMIFHTIEQLTLKLNRLKDMELAHRELLKSLGGESSGG
Sbjct: 1441 QGGNDDPRRPSRSPPSLALRDVGMIFHTIEQLTLKLNRLKDMELAHRELLKSLGGESSGG 1500
Query: 1461 TTPVGSFHTEAARWTDGSLSPPAKEPLASDSRNSHELGPCPEDGSDAPLEDSTADAAASP 1520
TTPVGSFHTEAARWTDGSLSPPAKEPLASDSRNSHELGPCPEDGSDAPLEDSTADAAASP
Sbjct: 1501 TTPVGSFHTEAARWTDGSLSPPAKEPLASDSRNSHELGPCPEDGSDAPLEDSTADAAASP 1560
Query: 1521 GP 1522
GP
Sbjct: 1561 GP 1562
>gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo
sapiens]
Length = 1544
Score = 660 bits (1702), Expect = 0.0
Identities = 439/1179 (37%), Positives = 642/1179 (54%), Gaps = 119/1179 (10%)
Query: 7 QSIDRLSSLSSLGDSAPERKSPSHHRQPSDASETTGLVQRCVIIQKDQHGFGFTVSGDRI 66
Q ++R++S + +K+ S + SE GLVQRCVIIQKD +GFG TVSGD
Sbjct: 34 QKVERIASHDFDPTDSSSKKTKSSSEE--SRSEIYGLVQRCVIIQKDDNGFGLTVSGDNP 91
Query: 67 VLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNSSHLEVVKLIKSGAYVALTLLGSSPSS 126
V VQSV+ GAAM+AGV+ GDRIIKVNGT+VT+S+HLEVVKLIKSG+YVALT+ G P S
Sbjct: 92 VFVQSVKEDGAAMRAGVQTGDRIIKVNGTLVTHSNHLEVVKLIKSGSYVALTVQGRPPGS 151
Query: 127 MGISGLQQDPSPAGAPRITSVIPSPPPPPPLPPPQRITGPKPLQDPE--VQKHATQILRN 184
I + P+ ++ ++ SP P +RIT P + + V +ILR
Sbjct: 152 PQIPLADSEVEPSVIGHMSPIMTSPHSPGASGNMERITSPVLMGEENNVVHNQKVEILRK 211
Query: 185 MLRQEEKELQDILPLYGDTSQRPSEGRLSLDSQEGDSGLDSGTERFPSLSESLMNRNSVL 244
ML++E++ LQ L D ++ P++ RL + QE + E+ + S + V
Sbjct: 212 MLQKEQERLQ---LLQEDYNRTPAQ-RLLKEIQEAKKHIPQLQEQLSKATGSAQDGAVVT 267
Query: 245 ---------------SDPG--------------------LDSPRTSPVIMARVAQHHRRQ 269
+DPG DSP++ P R+ +
Sbjct: 268 PSRPLGDTLTVSEAETDPGDVLGRTDCSSGDASRPSSDNADSPKSGP--KERIYLEENPE 325
Query: 270 GSDAAVPSTGDQGVDQSPK----PLIIGPEEDYDPGYFNNESDII------FQDLEKLKS 319
S+ + T Q + SP P IIG E+D F E + I FQ +E LKS
Sbjct: 326 KSET-IQDTDTQSLVGSPSTRIAPHIIGAEDDD----FGTEHEQINGQCSCFQSIELLKS 380
Query: 320 RPAHLGVFLRYIFSQADPSPLLFYLCAEVYQQASPKDSRSLGKDIWNIFLEKNAPLRVKI 379
RPAHL VFL ++ SQ DP+ LL YL +++Y+ + K++R + + FL+++A L+V +
Sbjct: 381 RPAHLAVFLHHVVSQFDPATLLCYLYSDLYKHTNSKETRRIFLEFHQFFLDRSAHLKVSV 440
Query: 380 PEMLQAEIDSR---LRNSEDARGVLCEAQEAAMPEIQEQIHDYRTKRTLGLGSLYGENDL 436
P+ + A+++ R L + R + QE PE+Q + D+R KR++GL E
Sbjct: 441 PDEMSADLEKRRPELIPEDLHRHYIQTMQERVHPEVQRHLEDFRQKRSMGLTLAESELTK 500
Query: 437 LDLDGDPLR-----ERQVAEKQLAALGDIL---SKYEEDRSAPMDFALNTYMSHAGIRLR 488
LD + D R ER AE+ +A + ++L EED+S+ M + + YM H G++++
Sbjct: 501 LDAERDKDRLTLEKERTCAEQIVAKIEEVLMTAQAVEEDKSSTMQYVILMYMKHLGVKVK 560
Query: 489 EARPSNTAEKAQSAPDKDKWLPFFPKTKKSSNSKKEKDALEDKKRNPILKYIGKPKSSSQ 548
E R + K + F PK K+S KK+K+ E KR +G P+ S+
Sbjct: 561 EPR---------NLEHKRGRIGFLPKIKQSM--KKDKEGEEKGKRRGFPSILGPPRRPSR 609
Query: 549 STFHIPLSPVEVK----------PGNVRNIIQHFENNQQYDAPEPGTQRLSTGSFPEDLL 598
+E++ P +V Q +Q GT G P +
Sbjct: 610 HDNSAIGRAMELQKARHPKHLSTPSSVSPEPQDSAKLRQSGLANEGTD---AGYLPAN-- 664
Query: 599 ESDSSRSEIRLGRSESLKGREEMKRSRKAENVPRSRSDVDMDAAAEATRLHQSASSSTSS 658
S S + G S S +G +E K + D +
Sbjct: 665 ----SMSSVASGASFSQEGGKENDTGSKQVGETSAPGDTLDGTPRTLNTVFDFPPPPLDQ 720
Query: 659 LSTRS--LENPTPPFTPKMGRRSIESPSLGFCTDTLLPHLLEDDLGQLSDLEPEPDAQNW 716
+ +E T TPK R+ S+ F E+DL E D NW
Sbjct: 721 VQEEECEVERVTEHGTPKPFRKF---DSVAFGESQSEDEQFENDL--------ETDPPNW 769
Query: 717 QHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELA 776
Q V ++V+ GL EI RQEVINELF TE +H+RTL+VLD +FYQR+ +E ++ EL
Sbjct: 770 QQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSELR 829
Query: 777 RLFPNLPELIEIHNSWCEAMKKLRE--EGPIIKEISDLMLARFDGPAREELQQVAAQFCS 834
++F NL +++++H E MK +R+ E +I +I + +L F GP E+L+ AA FCS
Sbjct: 830 KIFSNLEDILQLHIGLNEQMKAVRKRNETSVIDQIGEDLLTWFSGPGEEKLKHAAATFCS 889
Query: 835 YQSIALELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIK 894
Q ALE+IK++Q+K+SRFQ F+Q+AES+P CRRLQL+D+I ++MQRLTKYPLLL++I K
Sbjct: 890 NQPFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIAK 949
Query: 895 HTEGGTSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAA 954
+TE T E EK+ +A D CR+IL YVN+AVK+ EN+ RLE YQ+RLD ++L+ + P
Sbjct: 950 YTEWPT-EREKVKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSSLKLSEYPNVE 1008
Query: 955 EFKSLDLTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVG 1014
E ++LDLT RKMIHEGPL W++++DKT+DL+ LLLED+LVLLQKQD++L+L+CHSK
Sbjct: 1009 ELRNLDLTKRKMIHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDDRLVLRCHSKILAS 1068
Query: 1015 SSDSKQTFSPVLKLNAVLIRSVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELL 1074
++DSK TFSPV+KL+ VL+R VATD +A F+I S G QIYELVA T S+K W +L+
Sbjct: 1069 TADSKHTFSPVIKLSTVLVRQVATDNKALFVISMSDNG-AQIYELVAQTVSEKTVWQDLI 1127
Query: 1075 EEAVRNATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVE 1113
+ + + P+P+ PG + ++ P+ + E
Sbjct: 1128 CR-MAASVKEQSTKPIPLPQSTPGEGDNDEEDPSKLKEE 1165
>gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [Homo
sapiens]
Length = 927
Score = 447 bits (1149), Expect = e-125
Identities = 332/914 (36%), Positives = 487/914 (53%), Gaps = 105/914 (11%)
Query: 273 AAVPSTGDQGVDQSPKPLIIGPEEDYDPGYFNN--ESDIIFQDLEKLKSRPAHLGVFLRY 330
AA P G+ P +I +ED++ N E + FQ LE++K RPAHL L++
Sbjct: 23 AASPGPSRPGL--VPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLMALLQH 80
Query: 331 IFSQADPSPLLFYLCAEVYQQASPKDSRSLGKDIWNIFLEKNAPLRVKIPEMLQAEIDSR 390
+ Q +P PLL L A++ PK+++ D ++ FLEK A LRV +P + E+D
Sbjct: 81 VALQFEPGPLLCCLHADMLGSLGPKEAKKAFLDFYHSFLEKTAVLRVPVPPNVAFELDRT 140
Query: 391 LRN--SEDA-RGVLCEAQEAAMPEIQEQIHDYRTKRTLGLGSLYGENDLLDLDG------ 441
+ SED R + E ++ + Q+ D+R+KR +G+ E +L L+
Sbjct: 141 RADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPW--EQELAQLEAWVGRDR 198
Query: 442 --DPLRERQVAEKQLAALGDILSKY--EEDRSAPMDFALNTYMSHAGIRLREARPSNTAE 497
RER VAE+ L L ++ +E++SA + A+ YM H G+R +
Sbjct: 199 ASYEARERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSG------- 251
Query: 498 KAQSAPDKDKWLPFFPKTKKSSNSKKEKDALEDKKRNPILKYIGKPKSSSQSTFHIPLSP 557
DK FF K K N + ++ A K + IL + Q +P
Sbjct: 252 ------DKKSGRNFFRK-KVMGNRRSDEPAKTKKGLSSILDAARWNRGEPQ----VP--- 297
Query: 558 VEVKPGNVRNIIQHFENNQQYDAPEPG-TQRLSTGSFPEDLLESDSSRSEIRLGRSESLK 616
+ R++ + DA +PG T R P SR R+
Sbjct: 298 ------DFRHL------KAEVDAEKPGATDRKGGVGMP--------SRD-----RNIGAP 332
Query: 617 GREEMKRSRKAENVPRSRSDVDMDAAAEATRLHQSASSSTSSLSTRSLENPTPPFTPKMG 676
G++ S P S D + A+A L SS +S SL PP + G
Sbjct: 333 GQDTPGVSLH----PLSLDSPDREPGADAP-LELGDSSPQGPMSLESL---APPESTDEG 384
Query: 677 RRSIESPSLGFCTDTLLPHLLEDDLGQLS-DLEPEPDAQNWQHTVGKDVVAGLTQREIDR 735
+ ESP G E + G+ +LEPE + W+ V D + L + ++ R
Sbjct: 385 AET-ESPEPGD----------EGEPGRSGLELEPE-EPPGWRELVPPDTLHSLPKSQVKR 432
Query: 736 QEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEA 795
QEVI+EL VTEA+H+R LRVL +F+Q M + P EEL +FP+L ELIE+H+ + +
Sbjct: 433 QEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDR 492
Query: 796 MKKLREE-GPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQ 854
+ K R+E G +I+EI D++LARFDG Q+++++FCS QS ALE +K KQRK+ RF
Sbjct: 493 LMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFC 552
Query: 855 LFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCR 914
F+QEAES P+CRRLQL+D+I +EMQRLTKYPLLL+SI ++TE T E EK+ A + CR
Sbjct: 553 AFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPT-EREKVELAAECCR 611
Query: 915 EILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIHEGPLTW 974
EIL +VN+AV+ E+ RL+ YQ+RLD + L ++S+P+ +EFK+LD+T +K++HEGPLTW
Sbjct: 612 EILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTW 671
Query: 975 RISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIR 1034
R++KDK +++HVLLL+DLL+LLQ+QDE+LLLK HS+T + D K PVL+L + + R
Sbjct: 672 RVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTR 731
Query: 1035 SVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRN-ATRHPGAAPMPVH 1093
VATD +AF+++ T QIYELVA T S++ W L+ E + P + P P
Sbjct: 732 EVATDHKAFYVLFTWD-QEAQIYELVAQTVSERKNWCALITETAGSLKVPAPASRPKP-R 789
Query: 1094 PPPPGPREP-----------AQQGPTPSRVELDDSDVF-HGEPEPEELPGGTGSQQRVQG 1141
P P REP + P +R E SD+ P PE T + ++V
Sbjct: 790 PSPSSTREPLLSSSENGNGGRETSPADARTERILSDLLPFCRPGPEGQLAAT-ALRKVLS 848
Query: 1142 KHQVLLEDPEQEGS 1155
Q+L E G+
Sbjct: 849 LKQLLFPAEEDNGA 862
>gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [Homo
sapiens]
Length = 912
Score = 447 bits (1149), Expect = e-125
Identities = 332/914 (36%), Positives = 487/914 (53%), Gaps = 105/914 (11%)
Query: 273 AAVPSTGDQGVDQSPKPLIIGPEEDYDPGYFNN--ESDIIFQDLEKLKSRPAHLGVFLRY 330
AA P G+ P +I +ED++ N E + FQ LE++K RPAHL L++
Sbjct: 8 AASPGPSRPGL--VPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLMALLQH 65
Query: 331 IFSQADPSPLLFYLCAEVYQQASPKDSRSLGKDIWNIFLEKNAPLRVKIPEMLQAEIDSR 390
+ Q +P PLL L A++ PK+++ D ++ FLEK A LRV +P + E+D
Sbjct: 66 VALQFEPGPLLCCLHADMLGSLGPKEAKKAFLDFYHSFLEKTAVLRVPVPPNVAFELDRT 125
Query: 391 LRN--SEDA-RGVLCEAQEAAMPEIQEQIHDYRTKRTLGLGSLYGENDLLDLDG------ 441
+ SED R + E ++ + Q+ D+R+KR +G+ E +L L+
Sbjct: 126 RADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPW--EQELAQLEAWVGRDR 183
Query: 442 --DPLRERQVAEKQLAALGDILSKY--EEDRSAPMDFALNTYMSHAGIRLREARPSNTAE 497
RER VAE+ L L ++ +E++SA + A+ YM H G+R +
Sbjct: 184 ASYEARERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSG------- 236
Query: 498 KAQSAPDKDKWLPFFPKTKKSSNSKKEKDALEDKKRNPILKYIGKPKSSSQSTFHIPLSP 557
DK FF K K N + ++ A K + IL + Q +P
Sbjct: 237 ------DKKSGRNFFRK-KVMGNRRSDEPAKTKKGLSSILDAARWNRGEPQ----VP--- 282
Query: 558 VEVKPGNVRNIIQHFENNQQYDAPEPG-TQRLSTGSFPEDLLESDSSRSEIRLGRSESLK 616
+ R++ + DA +PG T R P SR R+
Sbjct: 283 ------DFRHL------KAEVDAEKPGATDRKGGVGMP--------SRD-----RNIGAP 317
Query: 617 GREEMKRSRKAENVPRSRSDVDMDAAAEATRLHQSASSSTSSLSTRSLENPTPPFTPKMG 676
G++ S P S D + A+A L SS +S SL PP + G
Sbjct: 318 GQDTPGVSLH----PLSLDSPDREPGADAP-LELGDSSPQGPMSLESL---APPESTDEG 369
Query: 677 RRSIESPSLGFCTDTLLPHLLEDDLGQLS-DLEPEPDAQNWQHTVGKDVVAGLTQREIDR 735
+ ESP G E + G+ +LEPE + W+ V D + L + ++ R
Sbjct: 370 AET-ESPEPGD----------EGEPGRSGLELEPE-EPPGWRELVPPDTLHSLPKSQVKR 417
Query: 736 QEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEA 795
QEVI+EL VTEA+H+R LRVL +F+Q M + P EEL +FP+L ELIE+H+ + +
Sbjct: 418 QEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDR 477
Query: 796 MKKLREE-GPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQ 854
+ K R+E G +I+EI D++LARFDG Q+++++FCS QS ALE +K KQRK+ RF
Sbjct: 478 LMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFC 537
Query: 855 LFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCR 914
F+QEAES P+CRRLQL+D+I +EMQRLTKYPLLL+SI ++TE T E EK+ A + CR
Sbjct: 538 AFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPT-EREKVELAAECCR 596
Query: 915 EILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIHEGPLTW 974
EIL +VN+AV+ E+ RL+ YQ+RLD + L ++S+P+ +EFK+LD+T +K++HEGPLTW
Sbjct: 597 EILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTW 656
Query: 975 RISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIR 1034
R++KDK +++HVLLL+DLL+LLQ+QDE+LLLK HS+T + D K PVL+L + + R
Sbjct: 657 RVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTR 716
Query: 1035 SVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRN-ATRHPGAAPMPVH 1093
VATD +AF+++ T QIYELVA T S++ W L+ E + P + P P
Sbjct: 717 EVATDHKAFYVLFTWD-QEAQIYELVAQTVSERKNWCALITETAGSLKVPAPASRPKP-R 774
Query: 1094 PPPPGPREP-----------AQQGPTPSRVELDDSDVF-HGEPEPEELPGGTGSQQRVQG 1141
P P REP + P +R E SD+ P PE T + ++V
Sbjct: 775 PSPSSTREPLLSSSENGNGGRETSPADARTERILSDLLPFCRPGPEGQLAAT-ALRKVLS 833
Query: 1142 KHQVLLEDPEQEGS 1155
Q+L E G+
Sbjct: 834 LKQLLFPAEEDNGA 847
>gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [Homo
sapiens]
Length = 879
Score = 413 bits (1062), Expect = e-115
Identities = 321/914 (35%), Positives = 470/914 (51%), Gaps = 138/914 (15%)
Query: 273 AAVPSTGDQGVDQSPKPLIIGPEEDYDPGYFNN--ESDIIFQDLEKLKSRPAHLGVFLRY 330
AA P G+ P +I +ED++ N E + FQ LE++K RPAHL L++
Sbjct: 8 AASPGPSRPGL--VPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLMALLQH 65
Query: 331 IFSQADPSPLLFYLCAEVYQQASPKDSRSLGKDIWNIFLEKNAPLRVKIPEMLQAEIDSR 390
+ Q +P PL+ LRV +P + E+D
Sbjct: 66 VALQFEPGPLV---------------------------------LRVPVPPNVAFELDRT 92
Query: 391 LRN--SEDA-RGVLCEAQEAAMPEIQEQIHDYRTKRTLGLGSLYGENDLLDLDG------ 441
+ SED R + E ++ + Q+ D+R+KR +G+ E +L L+
Sbjct: 93 RADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPW--EQELAQLEAWVGRDR 150
Query: 442 --DPLRERQVAEKQLAALGDILSKY--EEDRSAPMDFALNTYMSHAGIRLREARPSNTAE 497
RER VAE+ L L ++ +E++SA + A+ YM H G+R +
Sbjct: 151 ASYEARERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSG------- 203
Query: 498 KAQSAPDKDKWLPFFPKTKKSSNSKKEKDALEDKKRNPILKYIGKPKSSSQSTFHIPLSP 557
DK FF K K N + ++ A K + IL + Q +P
Sbjct: 204 ------DKKSGRNFFRK-KVMGNRRSDEPAKTKKGLSSILDAARWNRGEPQ----VP--- 249
Query: 558 VEVKPGNVRNIIQHFENNQQYDAPEPG-TQRLSTGSFPEDLLESDSSRSEIRLGRSESLK 616
+ R++ + DA +PG T R P SR R+
Sbjct: 250 ------DFRHL------KAEVDAEKPGATDRKGGVGMP--------SRD-----RNIGAP 284
Query: 617 GREEMKRSRKAENVPRSRSDVDMDAAAEATRLHQSASSSTSSLSTRSLENPTPPFTPKMG 676
G++ S P S D + A+A L SS +S SL PP + G
Sbjct: 285 GQDTPGVSLH----PLSLDSPDREPGADAP-LELGDSSPQGPMSLESL---APPESTDEG 336
Query: 677 RRSIESPSLGFCTDTLLPHLLEDDLGQLS-DLEPEPDAQNWQHTVGKDVVAGLTQREIDR 735
+ ESP G E + G+ +LEPE + W+ V D + L + ++ R
Sbjct: 337 AET-ESPEPGD----------EGEPGRSGLELEPE-EPPGWRELVPPDTLHSLPKSQVKR 384
Query: 736 QEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEA 795
QEVI+EL VTEA+H+R LRVL +F+Q M + P EEL +FP+L ELIE+H+ + +
Sbjct: 385 QEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDR 444
Query: 796 MKKLREE-GPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQ 854
+ K R+E G +I+EI D++LARFDG Q+++++FCS QS ALE +K KQRK+ RF
Sbjct: 445 LMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFC 504
Query: 855 LFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCR 914
F+QEAES P+CRRLQL+D+I +EMQRLTKYPLLL+SI ++TE T E EK+ A + CR
Sbjct: 505 AFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPT-EREKVELAAECCR 563
Query: 915 EILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIHEGPLTW 974
EIL +VN+AV+ E+ RL+ YQ+RLD + L ++S+P+ +EFK+LD+T +K++HEGPLTW
Sbjct: 564 EILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTW 623
Query: 975 RISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIR 1034
R++KDK +++HVLLL+DLL+LLQ+QDE+LLLK HS+T + D K PVL+L + + R
Sbjct: 624 RVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTR 683
Query: 1035 SVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRN-ATRHPGAAPMPVH 1093
VATD +AF+++ T QIYELVA T S++ W L+ E + P + P P
Sbjct: 684 EVATDHKAFYVLFTWD-QEAQIYELVAQTVSERKNWCALITETAGSLKVPAPASRPKP-R 741
Query: 1094 PPPPGPREP-----------AQQGPTPSRVELDDSDVF-HGEPEPEELPGGTGSQQRVQG 1141
P P REP + P +R E SD+ P PE T + ++V
Sbjct: 742 PSPSSTREPLLSSSENGNGGRETSPADARTERILSDLLPFCRPGPEGQLAAT-ALRKVLS 800
Query: 1142 KHQVLLEDPEQEGS 1155
Q+L E G+
Sbjct: 801 LKQLLFPAEEDNGA 814
>gi|195972857 Rho/Rac guanine nucleotide exchange factor 18 isoform b
[Homo sapiens]
Length = 1173
Score = 190 bits (482), Expect = 1e-47
Identities = 135/498 (27%), Positives = 246/498 (49%), Gaps = 50/498 (10%)
Query: 594 PEDLLESDSSRSEIR-LGRSESLKGREEMKRSRKAENVPRSRSDVDMDAAAEATRLHQSA 652
P L SD S + R +G + S KG + S +MD A A +
Sbjct: 141 PRGTLLSDGSPALSRNVGMTVSQKGGPQPTPSPAGPGTQLGPITGEMDEADSAFLKFKQT 200
Query: 653 SSSTSSLSTRSLEN--PTPPFTPKMGRRSIESPSLGFCTDTLLPHLLEDDLGQLSDLEPE 710
+ + SL++ + E+ P+T + R IES F
Sbjct: 201 ADDSLSLTSPNTESIFVEDPYTASL-RSEIESDGHEF----------------------- 236
Query: 711 PDAQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLM 770
+A++W V + + RQ+V+ EL TE H+RTL+++ ++ + +++E
Sbjct: 237 -EAESWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQF 295
Query: 771 PREELARLFPNLPELIEIHNSWCEAMKKLREEGP--------IIKEISDLMLARFDGPAR 822
+ + RLFP +L+E H+ + +K+ R+E +I++I DL++ +F G
Sbjct: 296 SSKAIGRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENG 355
Query: 823 EELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRL 882
E +++ FCS + A+ K ++ +FQ +++ + RRL +++ I+ QR+
Sbjct: 356 ERMKEKYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRI 415
Query: 883 TKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDA 942
TKYP+L+E II++TE GT ++E L +A + ++I+ V+ V + E RL ++D
Sbjct: 416 TKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDL 475
Query: 943 TALERASNPLAAEFKSLDLTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEK 1002
+ + N L F+ D+ R++ EG L W+ + + D+ +LL D+L+LLQ++D+K
Sbjct: 476 KSSSKLKNGLT--FRKEDMLQRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQK 533
Query: 1003 LLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFIICTSKLGPPQIYELVAL 1062
+ S DSK PV+ L +++R VA +++A F+I S G P++YE+
Sbjct: 534 YVF--------ASVDSK---PPVISLQKLIVREVANEEKAMFLISASLQG-PEMYEIYTS 581
Query: 1063 TSSDKNTWMELLEEAVRN 1080
+ D+N WM ++ AV +
Sbjct: 582 SKEDRNAWMAHIQRAVES 599
>gi|41327769 Rho/Rac guanine nucleotide exchange factor 18 isoform a
[Homo sapiens]
Length = 1015
Score = 189 bits (480), Expect = 2e-47
Identities = 111/379 (29%), Positives = 208/379 (54%), Gaps = 22/379 (5%)
Query: 710 EPDAQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENL 769
E +A++W V + + RQ+V+ EL TE H+RTL+++ ++ + +++E
Sbjct: 77 EFEAESWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQ 136
Query: 770 MPREELARLFPNLPELIEIHNSWCEAMKKLREEGP--------IIKEISDLMLARFDGPA 821
+ + RLFP +L+E H+ + +K+ R+E +I++I DL++ +F G
Sbjct: 137 FSSKAIGRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGEN 196
Query: 822 REELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQR 881
E +++ FCS + A+ K ++ +FQ +++ + RRL +++ I+ QR
Sbjct: 197 GERMKEKYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQR 256
Query: 882 LTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLD 941
+TKYP+L+E II++TE GT ++E L +A + ++I+ V+ V + E RL ++D
Sbjct: 257 ITKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMD 316
Query: 942 ATALERASNPLAAEFKSLDLTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDE 1001
+ + N L F+ D+ R++ EG L W+ + + D+ +LL D+L+LLQ++D+
Sbjct: 317 LKSSSKLKNGLT--FRKEDMLQRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQ 374
Query: 1002 KLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFIICTSKLGPPQIYELVA 1061
K + S DSK PV+ L +++R VA +++A F+I S G P++YE+
Sbjct: 375 KYVF--------ASVDSK---PPVISLQKLIVREVANEEKAMFLISASLQG-PEMYEIYT 422
Query: 1062 LTSSDKNTWMELLEEAVRN 1080
+ D+N WM ++ AV +
Sbjct: 423 SSKEDRNAWMAHIQRAVES 441
>gi|253735778 Rho/Rac guanine nucleotide exchange factor 2 isoform 2
[Homo sapiens]
Length = 985
Score = 185 bits (470), Expect = 3e-46
Identities = 128/453 (28%), Positives = 231/453 (50%), Gaps = 38/453 (8%)
Query: 646 TRLHQSASSSTSSLSTRSLENPTPPFTPKMGRR--SIESPSLGFCTDTLLPHLLEDDLGQ 703
+R +S+ S S+ST ++ +P RR S + SL TL L D+
Sbjct: 137 SRRGRSSLSLAKSVSTTNIAGHFNDESPLGLRRILSQSTDSLNMRNRTLSVESLIDEEVI 196
Query: 704 LSDL-------EPEPDAQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVL 756
S+L E + A +W V + + + +Q+VI EL TE H+RTL+++
Sbjct: 197 YSELMSDFEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIM 256
Query: 757 DLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEAMKKLREEGP--------IIKE 808
+F M +E + + LFP + EL +IH + + + R + +I
Sbjct: 257 TRLFRTGMLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHR 316
Query: 809 ISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRR 868
+ DL++++F GP+ E++ + ++FCS S AL+L K ++ RFQ F+++ +R
Sbjct: 317 LGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKR 376
Query: 869 LQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTE 928
+++ I+ QR+TKYPLL+ I++H+ G E + L A +E+L V+E + Q E
Sbjct: 377 HGVQECILLVTQRITKYPLLISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLE 436
Query: 929 NRHRLEGYQKRLDATALERASNPLAAE--FKSLDLTTRKMIHEGPLTWRISKDKTLDLHV 986
RL+ R+D RA P+ + F +L RK+IH+G L W+ + + D+ V
Sbjct: 437 KGARLQEIYNRMD----PRAQTPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLV 492
Query: 987 LLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFII 1046
LL+ D+LV LQ++D+K + K + V+ L +++R +A ++ F+I
Sbjct: 493 LLMTDVLVFLQEKDQKYIFPTLDKPS------------VVSLQNLIVRDIANQEKGMFLI 540
Query: 1047 CTSKLGPPQIYELVALTSSDKNTWMELLEEAVR 1079
+ PP++YE+ + D++TW+ +++++VR
Sbjct: 541 SAA---PPEMYEVHTASRDDRSTWIRVIQQSVR 570
>gi|15011974 Rho/Rac guanine nucleotide exchange factor 2 isooform 3
[Homo sapiens]
Length = 958
Score = 185 bits (470), Expect = 3e-46
Identities = 128/453 (28%), Positives = 231/453 (50%), Gaps = 38/453 (8%)
Query: 646 TRLHQSASSSTSSLSTRSLENPTPPFTPKMGRR--SIESPSLGFCTDTLLPHLLEDDLGQ 703
+R +S+ S S+ST ++ +P RR S + SL TL L D+
Sbjct: 110 SRRGRSSLSLAKSVSTTNIAGHFNDESPLGLRRILSQSTDSLNMRNRTLSVESLIDEEVI 169
Query: 704 LSDL-------EPEPDAQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVL 756
S+L E + A +W V + + + +Q+VI EL TE H+RTL+++
Sbjct: 170 YSELMSDFEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIM 229
Query: 757 DLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEAMKKLREEGP--------IIKE 808
+F M +E + + LFP + EL +IH + + + R + +I
Sbjct: 230 TRLFRTGMLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHR 289
Query: 809 ISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRR 868
+ DL++++F GP+ E++ + ++FCS S AL+L K ++ RFQ F+++ +R
Sbjct: 290 LGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKR 349
Query: 869 LQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTE 928
+++ I+ QR+TKYPLL+ I++H+ G E + L A +E+L V+E + Q E
Sbjct: 350 HGVQECILLVTQRITKYPLLISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLE 409
Query: 929 NRHRLEGYQKRLDATALERASNPLAAE--FKSLDLTTRKMIHEGPLTWRISKDKTLDLHV 986
RL+ R+D RA P+ + F +L RK+IH+G L W+ + + D+ V
Sbjct: 410 KGARLQEIYNRMD----PRAQTPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLV 465
Query: 987 LLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFII 1046
LL+ D+LV LQ++D+K + K + V+ L +++R +A ++ F+I
Sbjct: 466 LLMTDVLVFLQEKDQKYIFPTLDKPS------------VVSLQNLIVRDIANQEKGMFLI 513
Query: 1047 CTSKLGPPQIYELVALTSSDKNTWMELLEEAVR 1079
+ PP++YE+ + D++TW+ +++++VR
Sbjct: 514 SAA---PPEMYEVHTASRDDRSTWIRVIQQSVR 543
>gi|253735775 Rho/Rac guanine nucleotide exchange factor 2 isoform 1
[Homo sapiens]
Length = 986
Score = 184 bits (468), Expect = 4e-46
Identities = 128/454 (28%), Positives = 231/454 (50%), Gaps = 39/454 (8%)
Query: 646 TRLHQSASSSTSSLSTRSLENPTPPFTPKMGRR--SIESPSLGFCTDTLLPHLLEDDLGQ 703
+R +S+ S S+ST ++ +P RR S + SL TL L D+
Sbjct: 137 SRRGRSSLSLAKSVSTTNIAGHFNDESPLGLRRILSQSTDSLNMRNRTLSVESLIDEAEV 196
Query: 704 L-----SDLEPEPD---AQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRV 755
+ SD E + A +W V + + + +Q+VI EL TE H+RTL++
Sbjct: 197 IYSELMSDFEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKI 256
Query: 756 LDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEAMKKLREEGP--------IIK 807
+ +F M +E + + LFP + EL +IH + + + R + +I
Sbjct: 257 MTRLFRTGMLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIH 316
Query: 808 EISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCR 867
+ DL++++F GP+ E++ + ++FCS S AL+L K ++ RFQ F+++ +
Sbjct: 317 RLGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLK 376
Query: 868 RLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQT 927
R +++ I+ QR+TKYPLL+ I++H+ G E + L A +E+L V+E + Q
Sbjct: 377 RHGVQECILLVTQRITKYPLLISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQL 436
Query: 928 ENRHRLEGYQKRLDATALERASNPLAAE--FKSLDLTTRKMIHEGPLTWRISKDKTLDLH 985
E RL+ R+D RA P+ + F +L RK+IH+G L W+ + + D+
Sbjct: 437 EKGARLQEIYNRMD----PRAQTPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVL 492
Query: 986 VLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFI 1045
VLL+ D+LV LQ++D+K + K + V+ L +++R +A ++ F+
Sbjct: 493 VLLMTDVLVFLQEKDQKYIFPTLDKPS------------VVSLQNLIVRDIANQEKGMFL 540
Query: 1046 ICTSKLGPPQIYELVALTSSDKNTWMELLEEAVR 1079
I + PP++YE+ + D++TW+ +++++VR
Sbjct: 541 ISAA---PPEMYEVHTASRDDRSTWIRVIQQSVR 571
>gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens]
Length = 2817
Score = 178 bits (451), Expect = 4e-44
Identities = 183/805 (22%), Positives = 359/805 (44%), Gaps = 111/805 (13%)
Query: 515 TKKSSNSKKEKDALEDKKRNPILKYIGKPKSSSQSTFHIPLSPVEVKPGNVRNIIQHFEN 574
+KKS +KEKD +++K+++ K K + + IP+ V P + ++ F N
Sbjct: 1763 SKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPV----VGPISCSQCMKPFTN 1818
Query: 575 NQQYDAPEPGTQRLSTGSFPEDLLESDSSRSEIRLGRSE-SLKGREE------MKRSRKA 627
Y + + ES +S +++++ + + SL+ + + R++ +
Sbjct: 1819 KDAYTCAN------CSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKPS 1872
Query: 628 ENVPRSRSDVDM-DAAAE----ATRLHQSASSSTSSLSTRSL----ENPTPPFTPKMGRR 678
+ R RS V + D A A R Q + S + S+S +++ + T K
Sbjct: 1873 QPKERPRSAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSH 1932
Query: 679 SIES----PSLGFCTDTLLPHLLEDDLGQ---LSDLEPEP---DAQNWQHTVGKDVVAGL 728
S +S + T++L + D+ + L D E E +A++W + +
Sbjct: 1933 STDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQQ 1992
Query: 729 TQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEI 788
+ + RQEVI EL TE H+RTL+++ ++ Q M + L ++ + +LFP L ELI I
Sbjct: 1993 KKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISI 2052
Query: 789 HNSWCEAMKKLREEGPI--------IKEISDLMLARFDGPAREELQQVAAQFCSYQSIAL 840
H+ + + + + ++E + IK I D+++ +F G E L++ +FC + ++
Sbjct: 2053 HSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSV 2112
Query: 841 ELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGT 900
K K+ RFQ F+++ S RRL + + I+ QR+TKYP+L + I++ T+
Sbjct: 2113 NYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNE 2172
Query: 901 SEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLD 960
E E L ++ ++++ V+ V E + RL + D+ ++ R + F D
Sbjct: 2173 VEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKS--GQMFAKED 2230
Query: 961 LTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQ 1020
L +K++ +G + + + + ++ +LL D+LV LQ++D+K + S D K
Sbjct: 2231 LKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIF--------ASLDQKS 2282
Query: 1021 TFSPVLKLNAVLIRSVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRN 1080
T V+ L +++R VA +++ F+I + + P++ E+ A + ++N+W++++++ +
Sbjct: 2283 T---VISLKKLIVREVAHEEKGLFLI-SMGMTDPEMVEVHASSKEERNSWIQIIQDTINT 2338
Query: 1081 ATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEPEPEELPGGTGSQQRVQ 1140
R D+ + E E E+ T +++ +
Sbjct: 2339 LNR-------------------------------DEDEGIPSENEEEKKMLDTRARELKE 2367
Query: 1141 GKHQ----VLLEDPEQEGSAEEEELGVLPCPSTSLDGENRGIRTRNPIHLAFPGPLFMEG 1196
HQ +LL E+E + P P + + R+ A G M+
Sbjct: 2368 QLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDCSPTHSPRVLFRSNTEEALKGGPLMK- 2426
Query: 1197 LADSALEDVENLRHLILWSLLPGHTMETQAAQEPEDDLTPTPSVISVTSHPWDPGSPGQA 1256
SA+ +VE L+ L+ +L G T+ + E D+ S+ P +A
Sbjct: 2427 ---SAINEVEILQGLVSGNL--GGTLGPTVSSPIEQDVVGPVSL------------PRRA 2469
Query: 1257 PPGGEGDNTQLAGLEGERPEQEDMG 1281
G D+ Q+ +G E+ D G
Sbjct: 2470 ETFGGFDSHQMNASKGGEKEEGDDG 2494
>gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens]
Length = 1058
Score = 178 bits (451), Expect = 4e-44
Identities = 183/805 (22%), Positives = 359/805 (44%), Gaps = 111/805 (13%)
Query: 515 TKKSSNSKKEKDALEDKKRNPILKYIGKPKSSSQSTFHIPLSPVEVKPGNVRNIIQHFEN 574
+KKS +KEKD +++K+++ K K + + IP+ V P + ++ F N
Sbjct: 4 SKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPV----VGPISCSQCMKPFTN 59
Query: 575 NQQYDAPEPGTQRLSTGSFPEDLLESDSSRSEIRLGRSE-SLKGREE------MKRSRKA 627
Y + + ES +S +++++ + + SL+ + + R++ +
Sbjct: 60 KDAYTCAN------CSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKPS 113
Query: 628 ENVPRSRSDVDM-DAAAE----ATRLHQSASSSTSSLSTRSL----ENPTPPFTPKMGRR 678
+ R RS V + D A A R Q + S + S+S +++ + T K
Sbjct: 114 QPKERPRSAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSH 173
Query: 679 SIES----PSLGFCTDTLLPHLLEDDLGQ---LSDLEPEP---DAQNWQHTVGKDVVAGL 728
S +S + T++L + D+ + L D E E +A++W + +
Sbjct: 174 STDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQQ 233
Query: 729 TQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEI 788
+ + RQEVI EL TE H+RTL+++ ++ Q M + L ++ + +LFP L ELI I
Sbjct: 234 KKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISI 293
Query: 789 HNSWCEAMKKLREEGPI--------IKEISDLMLARFDGPAREELQQVAAQFCSYQSIAL 840
H+ + + + + ++E + IK I D+++ +F G E L++ +FC + ++
Sbjct: 294 HSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSV 353
Query: 841 ELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGT 900
K K+ RFQ F+++ S RRL + + I+ QR+TKYP+L + I++ T+
Sbjct: 354 NYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNE 413
Query: 901 SEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLD 960
E E L ++ ++++ V+ V E + RL + D+ ++ R + F D
Sbjct: 414 VEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKS--GQMFAKED 471
Query: 961 LTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQ 1020
L +K++ +G + + + + ++ +LL D+LV LQ++D+K + S D K
Sbjct: 472 LKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIF--------ASLDQKS 523
Query: 1021 TFSPVLKLNAVLIRSVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRN 1080
T V+ L +++R VA +++ F+I + + P++ E+ A + ++N+W++++++ +
Sbjct: 524 T---VISLKKLIVREVAHEEKGLFLI-SMGMTDPEMVEVHASSKEERNSWIQIIQDTINT 579
Query: 1081 ATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEPEPEELPGGTGSQQRVQ 1140
R D+ + E E E+ T +++ +
Sbjct: 580 LNR-------------------------------DEDEGIPSENEEEKKMLDTRARELKE 608
Query: 1141 GKHQ----VLLEDPEQEGSAEEEELGVLPCPSTSLDGENRGIRTRNPIHLAFPGPLFMEG 1196
HQ +LL E+E + P P + + R+ A G M+
Sbjct: 609 QLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDCSPTHSPRVLFRSNTEEALKGGPLMK- 667
Query: 1197 LADSALEDVENLRHLILWSLLPGHTMETQAAQEPEDDLTPTPSVISVTSHPWDPGSPGQA 1256
SA+ +VE L+ L+ +L G T+ + E D+ S+ P +A
Sbjct: 668 ---SAINEVEILQGLVSGNL--GGTLGPTVSSPIEQDVVGPVSL------------PRRA 710
Query: 1257 PPGGEGDNTQLAGLEGERPEQEDMG 1281
G D+ Q+ +G E+ D G
Sbjct: 711 ETFGGFDSHQMNASKGGEKEEGDDG 735
>gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens]
Length = 2813
Score = 178 bits (451), Expect = 4e-44
Identities = 183/805 (22%), Positives = 359/805 (44%), Gaps = 111/805 (13%)
Query: 515 TKKSSNSKKEKDALEDKKRNPILKYIGKPKSSSQSTFHIPLSPVEVKPGNVRNIIQHFEN 574
+KKS +KEKD +++K+++ K K + + IP+ V P + ++ F N
Sbjct: 1759 SKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPV----VGPISCSQCMKPFTN 1814
Query: 575 NQQYDAPEPGTQRLSTGSFPEDLLESDSSRSEIRLGRSE-SLKGREE------MKRSRKA 627
Y + + ES +S +++++ + + SL+ + + R++ +
Sbjct: 1815 KDAYTCAN------CSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKPS 1868
Query: 628 ENVPRSRSDVDM-DAAAE----ATRLHQSASSSTSSLSTRSL----ENPTPPFTPKMGRR 678
+ R RS V + D A A R Q + S + S+S +++ + T K
Sbjct: 1869 QPKERPRSAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSH 1928
Query: 679 SIES----PSLGFCTDTLLPHLLEDDLGQ---LSDLEPEP---DAQNWQHTVGKDVVAGL 728
S +S + T++L + D+ + L D E E +A++W + +
Sbjct: 1929 STDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQQ 1988
Query: 729 TQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEI 788
+ + RQEVI EL TE H+RTL+++ ++ Q M + L ++ + +LFP L ELI I
Sbjct: 1989 KKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISI 2048
Query: 789 HNSWCEAMKKLREEGPI--------IKEISDLMLARFDGPAREELQQVAAQFCSYQSIAL 840
H+ + + + + ++E + IK I D+++ +F G E L++ +FC + ++
Sbjct: 2049 HSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSV 2108
Query: 841 ELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGT 900
K K+ RFQ F+++ S RRL + + I+ QR+TKYP+L + I++ T+
Sbjct: 2109 NYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNE 2168
Query: 901 SEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLD 960
E E L ++ ++++ V+ V E + RL + D+ ++ R + F D
Sbjct: 2169 VEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKS--GQMFAKED 2226
Query: 961 LTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQ 1020
L +K++ +G + + + + ++ +LL D+LV LQ++D+K + S D K
Sbjct: 2227 LKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIF--------ASLDQKS 2278
Query: 1021 TFSPVLKLNAVLIRSVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRN 1080
T V+ L +++R VA +++ F+I + + P++ E+ A + ++N+W++++++ +
Sbjct: 2279 T---VISLKKLIVREVAHEEKGLFLI-SMGMTDPEMVEVHASSKEERNSWIQIIQDTINT 2334
Query: 1081 ATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEPEPEELPGGTGSQQRVQ 1140
R D+ + E E E+ T +++ +
Sbjct: 2335 LNR-------------------------------DEDEGIPSENEEEKKMLDTRARELKE 2363
Query: 1141 GKHQ----VLLEDPEQEGSAEEEELGVLPCPSTSLDGENRGIRTRNPIHLAFPGPLFMEG 1196
HQ +LL E+E + P P + + R+ A G M+
Sbjct: 2364 QLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDCSPTHSPRVLFRSNTEEALKGGPLMK- 2422
Query: 1197 LADSALEDVENLRHLILWSLLPGHTMETQAAQEPEDDLTPTPSVISVTSHPWDPGSPGQA 1256
SA+ +VE L+ L+ +L G T+ + E D+ S+ P +A
Sbjct: 2423 ---SAINEVEILQGLVSGNL--GGTLGPTVSSPIEQDVVGPVSL------------PRRA 2465
Query: 1257 PPGGEGDNTQLAGLEGERPEQEDMG 1281
G D+ Q+ +G E+ D G
Sbjct: 2466 ETFGGFDSHQMNASKGGEKEEGDDG 2490
>gi|122937434 Rho-guanine nucleotide exchange factor [Homo sapiens]
Length = 1651
Score = 169 bits (427), Expect = 2e-41
Identities = 132/524 (25%), Positives = 247/524 (47%), Gaps = 57/524 (10%)
Query: 574 NNQQYDAPEPGTQRLSTGSFPEDLLESDSSRSEIRLGRSESLKGREEMKRS---RKAENV 630
N+ D P+PG + S P L GR E++ + RS E+
Sbjct: 718 NSSFRDIPQPGLSLHPSSSVPVGL----------PTGRRETVGQVHPLSRSVPGTTLESF 767
Query: 631 PRSRSDVDMDAAAEATRLHQSASSSTSSLSTRSLENPTPPFTPKMGRRSIESPSL-GFCT 689
RS + ++ ++ + R + S+ + SPS F
Sbjct: 768 RRSATSLESESDHNSCRSRSHSDELLQSMGS--------------------SPSTESFIM 807
Query: 690 DTLLPHLLEDDLGQLSDLEPEPDAQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASH 749
+ ++ L DL SD + E +A++W V + I RQ+VI EL TE H
Sbjct: 808 EDVVDSSLWSDLS--SDAQ-EFEAESWSLVVDPSFCNRQEKDVIKRQDVIFELMQTEMHH 864
Query: 750 LRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEAMKKLREEGP----- 804
++TL ++ IF + MK+E + + ++FP L EL+EIH + +MK+ R+E
Sbjct: 865 IQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDELLEIHRHFFYSMKERRQESCAGSDR 924
Query: 805 --IIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAES 862
+I I D+++ +F +++++ +FC + A+ L K Q+ + +FQ F++ S
Sbjct: 925 NFVIDRIGDILVQQFSEENASKMKKIYGEFCCHHKEAVNLFKELQQNK-KFQNFIKLRNS 983
Query: 863 HPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNE 922
+ RR + + I+ QR+TKYP+L+E I+++T+ T EH+ L +A ++++ V+
Sbjct: 984 NLLARRRGIPECILLVTQRITKYPVLVERILQYTKERTEEHKDLRKALCLIKDMIATVDL 1043
Query: 923 AVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIHEGPLTWRISKDKTL 982
V + E + +++ + N ++L R ++++G + W+ + +
Sbjct: 1044 KVNEYEKNQKWLEILNKIENKTYTKLKNGHVFRKQALMSEERTLLYDGLVYWKTATGRFK 1103
Query: 983 DLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRA 1042
D+ LLL D+L+ LQ++D+K + AV S V+ L ++ R VA ++R
Sbjct: 1104 DILALLLTDVLLFLQEKDQKYIF-----AAVDQKPS------VISLQKLIAREVANEERG 1152
Query: 1043 FFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRNATRHPG 1086
F+I S G P++YE+ + ++N WM +++AV + G
Sbjct: 1153 MFLISASSAG-PEMYEIHTNSKEERNNWMRRIQQAVESCPEEKG 1195
>gi|38373682 pleckstrin homology domain containing family G member 5
isoform a [Homo sapiens]
Length = 1006
Score = 132 bits (331), Expect = 3e-30
Identities = 116/427 (27%), Positives = 198/427 (46%), Gaps = 55/427 (12%)
Query: 728 LTQREIDRQEVINELFVTEASHLRTLRVLDLIFY---QRMKKENLMPREELARLFPNLPE 784
LT+R+ +QE + EL TEAS++R LRV+ +F +++ L+ E RLF N+PE
Sbjct: 330 LTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPE 389
Query: 785 LIEIHNS-WCEAM----KKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIA 839
+ ++H W M +K R +++ L + G L + ++C +
Sbjct: 390 IAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFG----SLFKPYIRYCMEEEGC 445
Query: 840 LELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGG 899
+E ++ R F+ ++ AE HPQC+RL+L D++ QRLTKYPLLL+S+++ TE
Sbjct: 446 MEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEP 505
Query: 900 TSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERAS----NPLAAE 955
++ E + + +VN ++Q + R RL R+DA + +S + L E
Sbjct: 506 RAK-EAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKE 564
Query: 956 FKSLDLT----------TRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLL 1005
F LDLT TR+++ EG L + KD +D++ L DLL++ +
Sbjct: 565 FLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTK-------- 616
Query: 1006 KCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFIICTSKL-GPPQIYELVALTS 1064
AV ++ + P L ++ ++ R + D +F +I ++ Y A
Sbjct: 617 ------AVKKAERTRVIRPPLLVDKIVCREL-RDPGSFLLIYLNEFHSAVGAYTFQASGQ 669
Query: 1065 SDKNTWMELLEEAVRNATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEP 1124
+ W++ + A +N + A PPG ++P Q S E +D E
Sbjct: 670 ALCRGWVDTIYNA-QNQLQQLRA------QEPPGSQQPLQ-----SLEEEEDEQEEEEEE 717
Query: 1125 EPEELPG 1131
E EE G
Sbjct: 718 EEEEEEG 724
>gi|111154084 pleckstrin homology domain containing family G member 5
isoform b [Homo sapiens]
Length = 1083
Score = 132 bits (331), Expect = 3e-30
Identities = 116/427 (27%), Positives = 198/427 (46%), Gaps = 55/427 (12%)
Query: 728 LTQREIDRQEVINELFVTEASHLRTLRVLDLIFY---QRMKKENLMPREELARLFPNLPE 784
LT+R+ +QE + EL TEAS++R LRV+ +F +++ L+ E RLF N+PE
Sbjct: 407 LTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPE 466
Query: 785 LIEIHNS-WCEAM----KKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIA 839
+ ++H W M +K R +++ L + G L + ++C +
Sbjct: 467 IAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFG----SLFKPYIRYCMEEEGC 522
Query: 840 LELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGG 899
+E ++ R F+ ++ AE HPQC+RL+L D++ QRLTKYPLLL+S+++ TE
Sbjct: 523 MEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEP 582
Query: 900 TSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERAS----NPLAAE 955
++ E + + +VN ++Q + R RL R+DA + +S + L E
Sbjct: 583 RAK-EAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKE 641
Query: 956 FKSLDLT----------TRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLL 1005
F LDLT TR+++ EG L + KD +D++ L DLL++ +
Sbjct: 642 FLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTK-------- 693
Query: 1006 KCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFIICTSKL-GPPQIYELVALTS 1064
AV ++ + P L ++ ++ R + D +F +I ++ Y A
Sbjct: 694 ------AVKKAERTRVIRPPLLVDKIVCREL-RDPGSFLLIYLNEFHSAVGAYTFQASGQ 746
Query: 1065 SDKNTWMELLEEAVRNATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEP 1124
+ W++ + A +N + A PPG ++P Q S E +D E
Sbjct: 747 ALCRGWVDTIYNA-QNQLQQLRA------QEPPGSQQPLQ-----SLEEEEDEQEEEEEE 794
Query: 1125 EPEELPG 1131
E EE G
Sbjct: 795 EEEEEEG 801
>gi|111154088 pleckstrin homology domain containing family G member 5
isoform a [Homo sapiens]
Length = 1006
Score = 132 bits (331), Expect = 3e-30
Identities = 116/427 (27%), Positives = 198/427 (46%), Gaps = 55/427 (12%)
Query: 728 LTQREIDRQEVINELFVTEASHLRTLRVLDLIFY---QRMKKENLMPREELARLFPNLPE 784
LT+R+ +QE + EL TEAS++R LRV+ +F +++ L+ E RLF N+PE
Sbjct: 330 LTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPE 389
Query: 785 LIEIHNS-WCEAM----KKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIA 839
+ ++H W M +K R +++ L + G L + ++C +
Sbjct: 390 IAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFG----SLFKPYIRYCMEEEGC 445
Query: 840 LELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGG 899
+E ++ R F+ ++ AE HPQC+RL+L D++ QRLTKYPLLL+S+++ TE
Sbjct: 446 MEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEP 505
Query: 900 TSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERAS----NPLAAE 955
++ E + + +VN ++Q + R RL R+DA + +S + L E
Sbjct: 506 RAK-EAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKE 564
Query: 956 FKSLDLT----------TRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLL 1005
F LDLT TR+++ EG L + KD +D++ L DLL++ +
Sbjct: 565 FLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTK-------- 616
Query: 1006 KCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFIICTSKL-GPPQIYELVALTS 1064
AV ++ + P L ++ ++ R + D +F +I ++ Y A
Sbjct: 617 ------AVKKAERTRVIRPPLLVDKIVCREL-RDPGSFLLIYLNEFHSAVGAYTFQASGQ 669
Query: 1065 SDKNTWMELLEEAVRNATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEP 1124
+ W++ + A +N + A PPG ++P Q S E +D E
Sbjct: 670 ALCRGWVDTIYNA-QNQLQQLRA------QEPPGSQQPLQ-----SLEEEEDEQEEEEEE 717
Query: 1125 EPEELPG 1131
E EE G
Sbjct: 718 EEEEEEG 724
>gi|111154080 pleckstrin homology domain containing family G member 5
isoform a [Homo sapiens]
Length = 1006
Score = 132 bits (331), Expect = 3e-30
Identities = 116/427 (27%), Positives = 198/427 (46%), Gaps = 55/427 (12%)
Query: 728 LTQREIDRQEVINELFVTEASHLRTLRVLDLIFY---QRMKKENLMPREELARLFPNLPE 784
LT+R+ +QE + EL TEAS++R LRV+ +F +++ L+ E RLF N+PE
Sbjct: 330 LTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPE 389
Query: 785 LIEIHNS-WCEAM----KKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIA 839
+ ++H W M +K R +++ L + G L + ++C +
Sbjct: 390 IAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFG----SLFKPYIRYCMEEEGC 445
Query: 840 LELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGG 899
+E ++ R F+ ++ AE HPQC+RL+L D++ QRLTKYPLLL+S+++ TE
Sbjct: 446 MEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEP 505
Query: 900 TSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERAS----NPLAAE 955
++ E + + +VN ++Q + R RL R+DA + +S + L E
Sbjct: 506 RAK-EAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKE 564
Query: 956 FKSLDLT----------TRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLL 1005
F LDLT TR+++ EG L + KD +D++ L DLL++ +
Sbjct: 565 FLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTK-------- 616
Query: 1006 KCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFIICTSKL-GPPQIYELVALTS 1064
AV ++ + P L ++ ++ R + D +F +I ++ Y A
Sbjct: 617 ------AVKKAERTRVIRPPLLVDKIVCREL-RDPGSFLLIYLNEFHSAVGAYTFQASGQ 669
Query: 1065 SDKNTWMELLEEAVRNATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEP 1124
+ W++ + A +N + A PPG ++P Q S E +D E
Sbjct: 670 ALCRGWVDTIYNA-QNQLQQLRA------QEPPGSQQPLQ-----SLEEEEDEQEEEEEE 717
Query: 1125 EPEELPG 1131
E EE G
Sbjct: 718 EEEEEEG 724
>gi|111154078 pleckstrin homology domain containing family G member 5
isoform c [Homo sapiens]
Length = 1062
Score = 132 bits (331), Expect = 3e-30
Identities = 116/427 (27%), Positives = 198/427 (46%), Gaps = 55/427 (12%)
Query: 728 LTQREIDRQEVINELFVTEASHLRTLRVLDLIFY---QRMKKENLMPREELARLFPNLPE 784
LT+R+ +QE + EL TEAS++R LRV+ +F +++ L+ E RLF N+PE
Sbjct: 386 LTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPE 445
Query: 785 LIEIHNS-WCEAM----KKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIA 839
+ ++H W M +K R +++ L + G L + ++C +
Sbjct: 446 IAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFG----SLFKPYIRYCMEEEGC 501
Query: 840 LELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGG 899
+E ++ R F+ ++ AE HPQC+RL+L D++ QRLTKYPLLL+S+++ TE
Sbjct: 502 MEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEP 561
Query: 900 TSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERAS----NPLAAE 955
++ E + + +VN ++Q + R RL R+DA + +S + L E
Sbjct: 562 RAK-EAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKE 620
Query: 956 FKSLDLT----------TRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLL 1005
F LDLT TR+++ EG L + KD +D++ L DLL++ +
Sbjct: 621 FLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTK-------- 672
Query: 1006 KCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFIICTSKL-GPPQIYELVALTS 1064
AV ++ + P L ++ ++ R + D +F +I ++ Y A
Sbjct: 673 ------AVKKAERTRVIRPPLLVDKIVCREL-RDPGSFLLIYLNEFHSAVGAYTFQASGQ 725
Query: 1065 SDKNTWMELLEEAVRNATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEP 1124
+ W++ + A +N + A PPG ++P Q S E +D E
Sbjct: 726 ALCRGWVDTIYNA-QNQLQQLRA------QEPPGSQQPLQ-----SLEEEEDEQEEEEEE 773
Query: 1125 EPEELPG 1131
E EE G
Sbjct: 774 EEEEEEG 780
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 122 bits (306), Expect = 3e-27
Identities = 97/362 (26%), Positives = 170/362 (46%), Gaps = 35/362 (9%)
Query: 728 LTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIE 787
LT E RQ I+EL VTE +++ L+++ IF + + + L+ +E+A +F N ELI
Sbjct: 1231 LTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWKELIM 1290
Query: 788 IHNSWCEAM---KKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIK 844
+ +A+ KK+ E +K I D++ A+ Q +FCS Q LI+
Sbjct: 1291 CNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPH------MQPYIRFCSRQLNGAALIQ 1344
Query: 845 TKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHE 904
K + F+ F++ P+C+ + L I+ MQR+T+YPL++++I+++T +H
Sbjct: 1345 QKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHS 1404
Query: 905 KLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTR 964
L A ++ E+ VNE V++ EN RLE Q + L S L + L R
Sbjct: 1405 HLKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEGL---SEQLVFNSVTNCLGPR 1461
Query: 965 KMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSP 1024
K +H G L ++ +K +L+ L D L+L Q +GSS + + FSP
Sbjct: 1462 KFLHSGKL-YKAKSNK--ELYGFLFNDFLLLTQ-----------ITKPLGSSGTDKVFSP 1507
Query: 1025 VLKLNAVLIRSVATDKRAFFIICTSKLGP---------PQIYELVALTSSDKNTWMELLE 1075
L + ++ + T G ++Y L A + +++ W++ ++
Sbjct: 1508 KSNLQYKMYKTPIFLNEVLVKLPTDPSGDEPIFHISHIDRVYTLRAESINERTAWVQKIK 1567
Query: 1076 EA 1077
A
Sbjct: 1568 AA 1569
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 120 bits (301), Expect = 1e-26
Identities = 92/353 (26%), Positives = 171/353 (48%), Gaps = 24/353 (6%)
Query: 732 EIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNS 791
E RQ I+EL TE ++ L+++ +F +RM + + E+A +F N ELI +
Sbjct: 1180 ERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTK 1239
Query: 792 WCEAM---KKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQR 848
+A+ KK E ++ I D++ A Q +FCS Q L++ K
Sbjct: 1240 LLKALRVRKKTGGEKMPVQMIGDILAAELSH------MQAYIRFCSCQLNGAALLQQKTD 1293
Query: 849 KESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCR 908
+++ F+ F+++ S P+C+ + L ++ MQR+T+YPLL+ SI+++T ++H L
Sbjct: 1294 EDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKL 1353
Query: 909 ARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIH 968
A ++ E+ VNE V++ EN RLE Q + L + L + L RK++H
Sbjct: 1354 ALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGL---AEQLIFNSLTNCLGPRKLLH 1410
Query: 969 EGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSK-QTFSPVLK 1027
G L ++ +K +LH L D L+L + + K S+++ + + +
Sbjct: 1411 SGKL-YKTKSNK--ELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIF 1467
Query: 1028 LNAVLIR---SVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEA 1077
LN VL++ ++D+ F I + +Y L +++ W++ ++ A
Sbjct: 1468 LNEVLVKLPTDPSSDEPVFHISHIDR-----VYTLRTDNINERTAWVQKIKAA 1515
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 120 bits (301), Expect = 1e-26
Identities = 92/353 (26%), Positives = 171/353 (48%), Gaps = 24/353 (6%)
Query: 732 EIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNS 791
E RQ I+EL TE ++ L+++ +F +RM + + E+A +F N ELI +
Sbjct: 1207 ERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTK 1266
Query: 792 WCEAM---KKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQR 848
+A+ KK E ++ I D++ A Q +FCS Q L++ K
Sbjct: 1267 LLKALRVRKKTGGEKMPVQMIGDILAAELSH------MQAYIRFCSCQLNGAALLQQKTD 1320
Query: 849 KESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCR 908
+++ F+ F+++ S P+C+ + L ++ MQR+T+YPLL+ SI+++T ++H L
Sbjct: 1321 EDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKL 1380
Query: 909 ARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIH 968
A ++ E+ VNE V++ EN RLE Q + L + L + L RK++H
Sbjct: 1381 ALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGL---AEQLIFNSLTNCLGPRKLLH 1437
Query: 969 EGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSK-QTFSPVLK 1027
G L ++ +K +LH L D L+L + + K S+++ + + +
Sbjct: 1438 SGKL-YKTKSNK--ELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIF 1494
Query: 1028 LNAVLIR---SVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEA 1077
LN VL++ ++D+ F I + +Y L +++ W++ ++ A
Sbjct: 1495 LNEVLVKLPTDPSSDEPVFHISHIDR-----VYTLRTDNINERTAWVQKIKAA 1542
>gi|222080070 pleckstrin homology domain-containing family G member 6
isoform b [Homo sapiens]
Length = 758
Score = 96.3 bits (238), Expect = 2e-19
Identities = 113/464 (24%), Positives = 195/464 (42%), Gaps = 58/464 (12%)
Query: 653 SSSTSSLSTRSLENPTPP--FTPKMGRRSIESPSLGFCTDTLLPHLLEDDLGQLSDLE-- 708
S LS L +P P +G + SP L T H LE L S
Sbjct: 31 SGQARGLSPMRLRDPEPEKRHGGHVGAGLLHSPKLKELTKA---HELEVRLHTFSMFGMP 87
Query: 709 --PEPDAQNWQHTVGKD-----------VVAG---LTQREIDRQEVINELFVTEASHLRT 752
P D ++W+ G D +V G ++Q +QE + EL TE ++R
Sbjct: 88 RLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRK 147
Query: 753 LRVL-DLIF--YQRMKKENLMPREELARLFPNLPELIEIHNS-WCEAMKKLREEGPIIKE 808
L+++ DL+ +++ L+ LF N+P LI H S W E + EE +
Sbjct: 148 LKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQ 207
Query: 809 ISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRR 868
D + + + Q+C + + +Q F F+Q E H + R
Sbjct: 208 PLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGR 267
Query: 869 LQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTE 928
L DL+I QR+TKYPLLL +++K + ++ E L + L+++N V+Q E
Sbjct: 268 QMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQ-EALNAMIEAVESFLRHINGQVRQGE 326
Query: 929 NRHRLEGYQKRLDA-TALERASNPLAAE---FKSLDLT----------TRKMIHEGPLTW 974
+ L +R+ LE S+ + F +LDLT TR+++ EGP+
Sbjct: 327 EQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRV 386
Query: 975 RISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIR 1034
+ ++ LD+++ L D+L++ + Q + +D + P L L ++ +
Sbjct: 387 KEGREGKLDVYLFLFSDVLLVTKPQRK--------------ADKAKVIRPPLMLEKLVCQ 432
Query: 1035 SVATDKRAFFIICTSKLGPPQIYELVALTS-SDKNTWMELLEEA 1077
+ D +F +I ++ LV S +D+ W+E ++A
Sbjct: 433 PL-RDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQA 475
>gi|222080068 pleckstrin homology domain-containing family G member 6
isoform a [Homo sapiens]
Length = 790
Score = 96.3 bits (238), Expect = 2e-19
Identities = 113/464 (24%), Positives = 195/464 (42%), Gaps = 58/464 (12%)
Query: 653 SSSTSSLSTRSLENPTPP--FTPKMGRRSIESPSLGFCTDTLLPHLLEDDLGQLSDLE-- 708
S LS L +P P +G + SP L T H LE L S
Sbjct: 63 SGQARGLSPMRLRDPEPEKRHGGHVGAGLLHSPKLKELTKA---HELEVRLHTFSMFGMP 119
Query: 709 --PEPDAQNWQHTVGKD-----------VVAG---LTQREIDRQEVINELFVTEASHLRT 752
P D ++W+ G D +V G ++Q +QE + EL TE ++R
Sbjct: 120 RLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRK 179
Query: 753 LRVL-DLIF--YQRMKKENLMPREELARLFPNLPELIEIHNS-WCEAMKKLREEGPIIKE 808
L+++ DL+ +++ L+ LF N+P LI H S W E + EE +
Sbjct: 180 LKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQ 239
Query: 809 ISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRR 868
D + + + Q+C + + +Q F F+Q E H + R
Sbjct: 240 PLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGR 299
Query: 869 LQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTE 928
L DL+I QR+TKYPLLL +++K + ++ E L + L+++N V+Q E
Sbjct: 300 QMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQ-EALNAMIEAVESFLRHINGQVRQGE 358
Query: 929 NRHRLEGYQKRLDA-TALERASNPLAAE---FKSLDLT----------TRKMIHEGPLTW 974
+ L +R+ LE S+ + F +LDLT TR+++ EGP+
Sbjct: 359 EQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRV 418
Query: 975 RISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIR 1034
+ ++ LD+++ L D+L++ + Q + +D + P L L ++ +
Sbjct: 419 KEGREGKLDVYLFLFSDVLLVTKPQRK--------------ADKAKVIRPPLMLEKLVCQ 464
Query: 1035 SVATDKRAFFIICTSKLGPPQIYELVALTS-SDKNTWMELLEEA 1077
+ D +F +I ++ LV S +D+ W+E ++A
Sbjct: 465 PL-RDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQA 507
>gi|222080066 pleckstrin homology domain-containing family G member 6
isoform a [Homo sapiens]
Length = 790
Score = 96.3 bits (238), Expect = 2e-19
Identities = 113/464 (24%), Positives = 195/464 (42%), Gaps = 58/464 (12%)
Query: 653 SSSTSSLSTRSLENPTPP--FTPKMGRRSIESPSLGFCTDTLLPHLLEDDLGQLSDLE-- 708
S LS L +P P +G + SP L T H LE L S
Sbjct: 63 SGQARGLSPMRLRDPEPEKRHGGHVGAGLLHSPKLKELTKA---HELEVRLHTFSMFGMP 119
Query: 709 --PEPDAQNWQHTVGKD-----------VVAG---LTQREIDRQEVINELFVTEASHLRT 752
P D ++W+ G D +V G ++Q +QE + EL TE ++R
Sbjct: 120 RLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRK 179
Query: 753 LRVL-DLIF--YQRMKKENLMPREELARLFPNLPELIEIHNS-WCEAMKKLREEGPIIKE 808
L+++ DL+ +++ L+ LF N+P LI H S W E + EE +
Sbjct: 180 LKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQ 239
Query: 809 ISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRR 868
D + + + Q+C + + +Q F F+Q E H + R
Sbjct: 240 PLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGR 299
Query: 869 LQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTE 928
L DL+I QR+TKYPLLL +++K + ++ E L + L+++N V+Q E
Sbjct: 300 QMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQ-EALNAMIEAVESFLRHINGQVRQGE 358
Query: 929 NRHRLEGYQKRLDA-TALERASNPLAAE---FKSLDLT----------TRKMIHEGPLTW 974
+ L +R+ LE S+ + F +LDLT TR+++ EGP+
Sbjct: 359 EQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRV 418
Query: 975 RISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIR 1034
+ ++ LD+++ L D+L++ + Q + +D + P L L ++ +
Sbjct: 419 KEGREGKLDVYLFLFSDVLLVTKPQRK--------------ADKAKVIRPPLMLEKLVCQ 464
Query: 1035 SVATDKRAFFIICTSKLGPPQIYELVALTS-SDKNTWMELLEEA 1077
+ D +F +I ++ LV S +D+ W+E ++A
Sbjct: 465 PL-RDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQA 507
>gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2 [Homo
sapiens]
Length = 532
Score = 90.9 bits (224), Expect = 9e-18
Identities = 120/520 (23%), Positives = 214/520 (41%), Gaps = 65/520 (12%)
Query: 614 SLKGREEMKRSRKAEN-----VPRSRSDVDMDAAAEATRLHQSASSSTSSLSTRSLENPT 668
S G+ E++R+R+ N + R S ++ +AT L + + + S+S RS P
Sbjct: 27 STTGQMELRRTREPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSESRP- 85
Query: 669 PPFTPKMGRRSIESPSLGFCTDTLLPHLLEDDLGQLSDLEPEPDAQNWQHTVGKDVVAGL 728
D L P + S D++ W T V L
Sbjct: 86 ---------------------DILAPRPWSRNAAPSST--KRRDSKLWSETFDVCVNQML 122
Query: 729 TQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEI 788
T +EI RQE I EL E + L++ ++ M K ++M +EL ++F L LI +
Sbjct: 123 TSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPL 182
Query: 789 HNSWCEAMKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQR 848
H ++ +R+ + + +++ + + +CS Q A L+ K +
Sbjct: 183 HEELLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYD------SYCSNQVAAKALLDHK-K 235
Query: 849 KESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCR 908
++ R Q F+Q P R+L L + + RL KYPLLL I++HT + + L
Sbjct: 236 QDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEE 295
Query: 909 ARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIH 968
A + + I+ +N ++E R+ Y++RL LE SL ++R +
Sbjct: 296 AINIIQGIVAEINTKTGESECRY----YKERL--LYLEEGQK------DSLIDSSRVLCC 343
Query: 969 EGPLTWRISKDKTLDLHVLLLEDLLVLLQ--KQDEKLLLKCHSK-TAVGSSDSKQTFSPV 1025
G L ++ + LHV L +++LV+ + +E+L + + + V +
Sbjct: 344 HGEL----KNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDGE 399
Query: 1026 LKLNAVLIRSVATDKRA--FFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRNATR 1083
++L L + + ++R FF + Q + L A + +K W+ + +A
Sbjct: 400 VRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETVLC 459
Query: 1084 HPGAAPM-----PVHPPPPGPREPAQQGPTPSRVELDDSD 1118
G A + P G RE QG T ++D SD
Sbjct: 460 AAGQAGVLDSEGSFLNPTTGSRE--LQGETKLE-QMDQSD 496
>gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1 [Homo
sapiens]
Length = 558
Score = 89.0 bits (219), Expect = 3e-17
Identities = 100/417 (23%), Positives = 180/417 (43%), Gaps = 36/417 (8%)
Query: 712 DAQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMP 771
D++ W T V LT +EI RQE I EL E + L++ ++ M K ++M
Sbjct: 132 DSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMT 191
Query: 772 REELARLFPNLPELIEIHNSWCEAMKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQ 831
+EL ++F L LI +H ++ +R+ + + +++ + +
Sbjct: 192 EQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYD------S 245
Query: 832 FCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLES 891
+CS Q A L+ K +++ R Q F+Q P R+L L + + RL KYPLLL
Sbjct: 246 YCSNQVAAKALLDHK-KQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLRE 304
Query: 892 IIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNP 951
I++HT + + L A + + I+ +N ++E R+ Y++RL LE
Sbjct: 305 ILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRY----YKERL--LYLEEGQK- 357
Query: 952 LAAEFKSLDLTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQ--KQDEKLLLKCHS 1009
SL ++R + G L ++ + LHV L +++LV+ + +E+L + +
Sbjct: 358 -----DSLIDSSRVLCCHGEL----KNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYR 408
Query: 1010 K-TAVGSSDSKQTFSPVLKLNAVLIRSVATDKRA--FFIICTSKLGPPQIYELVALTSSD 1066
+ V + ++L L + + ++R FF + Q + L A + +
Sbjct: 409 QPIPVKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFN 468
Query: 1067 KNTWMELLEEAVRNATRHPGAAPM-----PVHPPPPGPREPAQQGPTPSRVELDDSD 1118
K W+ + +A G A + P G RE QG T ++D SD
Sbjct: 469 KQQWLNCIRQAKETVLCAAGQAGVLDSEGSFLNPTTGSRE--LQGETKLE-QMDQSD 522
>gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [Homo
sapiens]
Length = 526
Score = 89.0 bits (219), Expect = 3e-17
Identities = 100/417 (23%), Positives = 180/417 (43%), Gaps = 36/417 (8%)
Query: 712 DAQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMP 771
D++ W T V LT +EI RQE I EL E + L++ ++ M K ++M
Sbjct: 100 DSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMT 159
Query: 772 REELARLFPNLPELIEIHNSWCEAMKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQ 831
+EL ++F L LI +H ++ +R+ + + +++ + +
Sbjct: 160 EQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYD------S 213
Query: 832 FCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLES 891
+CS Q A L+ K +++ R Q F+Q P R+L L + + RL KYPLLL
Sbjct: 214 YCSNQVAAKALLDHK-KQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLRE 272
Query: 892 IIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNP 951
I++HT + + L A + + I+ +N ++E R+ Y++RL LE
Sbjct: 273 ILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRY----YKERL--LYLEEGQK- 325
Query: 952 LAAEFKSLDLTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQ--KQDEKLLLKCHS 1009
SL ++R + G L ++ + LHV L +++LV+ + +E+L + +
Sbjct: 326 -----DSLIDSSRVLCCHGEL----KNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYR 376
Query: 1010 K-TAVGSSDSKQTFSPVLKLNAVLIRSVATDKRA--FFIICTSKLGPPQIYELVALTSSD 1066
+ V + ++L L + + ++R FF + Q + L A + +
Sbjct: 377 QPIPVKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFN 436
Query: 1067 KNTWMELLEEAVRNATRHPGAAPM-----PVHPPPPGPREPAQQGPTPSRVELDDSD 1118
K W+ + +A G A + P G RE QG T ++D SD
Sbjct: 437 KQQWLNCIRQAKETVLCAAGQAGVLDSEGSFLNPTTGSRE--LQGETKLE-QMDQSD 490
>gi|21735572 epithelial cell transforming sequence 2 oncogene protein
[Homo sapiens]
Length = 883
Score = 85.5 bits (210), Expect = 4e-16
Identities = 99/470 (21%), Positives = 197/470 (41%), Gaps = 43/470 (9%)
Query: 637 VDMDA-AAEATRLHQSASSSTSSLSTRSLENPTPPFTPKMGRRSIESPSLGFCTDTL--- 692
+ MDA A E L++ A++ S L TP K R L TD
Sbjct: 310 IQMDARAGETMYLYEKANTPELKKSVSMLSLNTPNSNRKRRRLKETLAQLSRETDVSPFP 369
Query: 693 ------LPHLLEDDLGQLSDLEPEPDAQ-NWQHTVGKDVVAG-----LTQREIDRQEVIN 740
H L +G L D+ P++ N+ T + + ++ R +V
Sbjct: 370 PRKRPSAEHSLS--IGSLLDISNTPESSINYGDTPKSCTKSSKSSTPVPSKQSARWQVAK 427
Query: 741 ELFVTEASHLRTLRVLDLIFYQRMKKEN-----LMPREELARLFPNLPELIEIHNSWCEA 795
EL+ TE++++ L + +F +++E ++ EE+ +F ++P++ ++H +
Sbjct: 428 ELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDIFDVHTKIKDD 487
Query: 796 MKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQL 855
++ L K I D+ L ++L + F ++ ++ E I ++++ RF
Sbjct: 488 LEDLIVNWDESKSIGDIFLKY-----SKDLVKTYPPFVNFFEMSKETIIKCEKQKPRFHA 542
Query: 856 FMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCRE 915
F++ ++ P+C R L +L+I +QRL LLL + KHT + L +A +E
Sbjct: 543 FLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLEKAIGSLKE 602
Query: 916 ILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIHEGPLTWR 975
++ ++NE ++TE + ++ +D +N L++ + + E P
Sbjct: 603 VMTHINEDKRKTEAQKQIFDVVYEVDGC----PANLLSSHRSLVQRVETISLGEHPC--- 655
Query: 976 ISKDKTLDLHVLLLEDLLVLLQKQDEKL--LLKCHSKTAVGSSDSKQTFSPVLKLNAVL- 1032
D+ + + L D L + +K+ + + H +T +S P+ ++ VL
Sbjct: 656 ---DRGEQVTLFLFNDCLEIARKRHKVIGTFRSPHGQTRPPASLKHIHLMPLSQIKKVLD 712
Query: 1033 IRSVATDKRAFFIICTSKLGPPQIYELVALTSSD--KNTWMELLEEAVRN 1080
IR AF ++ + +TS + K W+++L V N
Sbjct: 713 IRETEDCHNAFALLVRPPTEQANVLLSFQMTSDELPKENWLKMLCRHVAN 762
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.131 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 70,111,794
Number of Sequences: 37866
Number of extensions: 4093046
Number of successful extensions: 37269
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 365
Number of HSP's successfully gapped in prelim test: 649
Number of HSP's that attempted gapping in prelim test: 24826
Number of HSP's gapped (non-prelim): 10916
length of query: 1522
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1407
effective length of database: 13,892,928
effective search space: 19547349696
effective search space used: 19547349696
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.