Search of human proteins with 73695465

Search of human proteins with 73695465

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|73695465 synaptic vesicle glycoprotein 2C [Homo sapiens]
         (727 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|73695465 synaptic vesicle glycoprotein 2C [Homo sapiens]          1493   0.0  
gi|216548223 synaptic vesicle glycoprotein 2 [Homo sapiens]           941   0.0  
gi|7662270 synaptic vesicle protein 2B homolog [Homo sapiens]         847   0.0  
gi|24308167 SV2 related protein [Homo sapiens]                        123   5e-28
gi|213021148 SVOP-like isoform 1 [Homo sapiens]                       103   6e-22
gi|4507005 solute carrier family 22 member 5 [Homo sapiens]            90   6e-18
gi|24497490 solute carrier family 22 member 4 [Homo sapiens]           70   5e-12
gi|24497497 solute carrier family 22 member 7 isoform a [Homo sa...    70   9e-12
gi|90669191 solute carrier family 22 member 7 isoform b [Homo sa...    69   2e-11
gi|21361449 solute carrier family 2 (facilitated glucose transpo...    69   2e-11
gi|166197673 solute carrier family 22, member 15 [Homo sapiens]        66   1e-10
gi|166064021 solute carrier family 22 (organic anion transporter...    66   1e-10
gi|223029432 solute carrier family 2 (facilitated glucose transp...    62   2e-09
gi|223029430 solute carrier family 2 (facilitated glucose transp...    62   2e-09
gi|157426885 organic cation transporter like 4 [Homo sapiens]          60   5e-09
gi|11415038 solute carrier family 22 member 3 [Homo sapiens]           58   4e-08
gi|4506999 solute carrier family 22 member 1 isoform a [Homo sap...    57   5e-08
gi|4507001 solute carrier family 22 member 2 [Homo sapiens]            57   6e-08
gi|33457322 SVOP-like isoform 2 [Homo sapiens]                         57   6e-08
gi|31542327 solute carrier family 22, member 16 [Homo sapiens]         57   6e-08
gi|203098995 solute carrier family 2 (facilitated glucose transp...    55   2e-07
gi|8923870 solute carrier family 22 member 11 [Homo sapiens]           54   5e-07
gi|23510410 solute carrier family 22 member 1 isoform b [Homo sa...    53   9e-07
gi|21553331 solute carrier family 2 (facilitated glucose transpo...    53   9e-07
gi|24497480 solute carrier family 22 member 6 isoform d [Homo sa...    52   2e-06
gi|24497478 solute carrier family 22 member 6 isoform c [Homo sa...    52   2e-06
gi|24497476 solute carrier family 22 member 6 isoform b [Homo sa...    52   2e-06
gi|20070188 solute carrier family 22 member 6 isoform a [Homo sa...    52   2e-06
gi|24497499 solute carrier family 22 member 8 [Homo sapiens]           52   3e-06
gi|5902090 solute carrier family 2 (facilitated glucose transpor...    51   3e-06

>gi|73695465 synaptic vesicle glycoprotein 2C [Homo sapiens]
          Length = 727

 Score = 1493 bits (3866), Expect = 0.0
 Identities = 727/727 (100%), Positives = 727/727 (100%)

Query: 1   MEDSYKDRTSLMKGAKDIAREVKKQTVKKVNQAVDRAQDEYTQRSYSRFQDEEDDDDYYP 60
           MEDSYKDRTSLMKGAKDIAREVKKQTVKKVNQAVDRAQDEYTQRSYSRFQDEEDDDDYYP
Sbjct: 1   MEDSYKDRTSLMKGAKDIAREVKKQTVKKVNQAVDRAQDEYTQRSYSRFQDEEDDDDYYP 60

Query: 61  AGETYNGEANDDEGSSEATEGHDEDDEIYEGEYQGIPSMNQAKDSIVSVGQPKGDEYKDR 120
           AGETYNGEANDDEGSSEATEGHDEDDEIYEGEYQGIPSMNQAKDSIVSVGQPKGDEYKDR
Sbjct: 61  AGETYNGEANDDEGSSEATEGHDEDDEIYEGEYQGIPSMNQAKDSIVSVGQPKGDEYKDR 120

Query: 121 RELESERRADEEELAQQYELIIQECGHGRFQWALFFVLGMALMADGVEVFVVGFVLPSAE 180
           RELESERRADEEELAQQYELIIQECGHGRFQWALFFVLGMALMADGVEVFVVGFVLPSAE
Sbjct: 121 RELESERRADEEELAQQYELIIQECGHGRFQWALFFVLGMALMADGVEVFVVGFVLPSAE 180

Query: 181 TDLCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQG 240
           TDLCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQG
Sbjct: 181 TDLCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQG 240

Query: 241 YGFFLFCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAI 300
           YGFFLFCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAI
Sbjct: 241 YGFFLFCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAI 300

Query: 301 IPHYGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMIL 360
           IPHYGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMIL
Sbjct: 301 IPHYGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMIL 360

Query: 361 KLIHDTNMRARGQPEKVFTVNKIKTPKQIDELIEIESDTGTWYRRCFVRIRTELYGIWLT 420
           KLIHDTNMRARGQPEKVFTVNKIKTPKQIDELIEIESDTGTWYRRCFVRIRTELYGIWLT
Sbjct: 361 KLIHDTNMRARGQPEKVFTVNKIKTPKQIDELIEIESDTGTWYRRCFVRIRTELYGIWLT 420

Query: 421 FMRCFNYPVRDNTIKLTIVWFTLSFGYYGLSVWFPDVIKPLQSDEYALLTRNVERDKYAN 480
           FMRCFNYPVRDNTIKLTIVWFTLSFGYYGLSVWFPDVIKPLQSDEYALLTRNVERDKYAN
Sbjct: 421 FMRCFNYPVRDNTIKLTIVWFTLSFGYYGLSVWFPDVIKPLQSDEYALLTRNVERDKYAN 480

Query: 481 FTINFTMENQIHTGMEYDNGRFIGVKFKSVTFKDSVFKSCTFEDVTSVNTYFKNCTFIDT 540
           FTINFTMENQIHTGMEYDNGRFIGVKFKSVTFKDSVFKSCTFEDVTSVNTYFKNCTFIDT
Sbjct: 481 FTINFTMENQIHTGMEYDNGRFIGVKFKSVTFKDSVFKSCTFEDVTSVNTYFKNCTFIDT 540

Query: 541 VFDNTDFEPYKFIDSEFKNCSFFHNKTGCQITFDDDYSAYWIYFVNFLGTLAVLPGNIVS 600
           VFDNTDFEPYKFIDSEFKNCSFFHNKTGCQITFDDDYSAYWIYFVNFLGTLAVLPGNIVS
Sbjct: 541 VFDNTDFEPYKFIDSEFKNCSFFHNKTGCQITFDDDYSAYWIYFVNFLGTLAVLPGNIVS 600

Query: 601 ALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSLDVVTVE 660
           ALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSLDVVTVE
Sbjct: 601 ALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSLDVVTVE 660

Query: 661 LYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKSIPILLASTVLVCGGLVGLCLPD 720
           LYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKSIPILLASTVLVCGGLVGLCLPD
Sbjct: 661 LYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKSIPILLASTVLVCGGLVGLCLPD 720

Query: 721 TRTQVLM 727
           TRTQVLM
Sbjct: 721 TRTQVLM 727


>gi|216548223 synaptic vesicle glycoprotein 2 [Homo sapiens]
          Length = 742

 Score =  941 bits (2431), Expect = 0.0
 Identities = 467/741 (63%), Positives = 564/741 (76%), Gaps = 15/741 (2%)

Query: 1   MEDSYKDRTSLMKGAKDIAREVKKQTVKKVNQAVDRAQDEYTQRSYSRFQDEEDDDDY-Y 59
           ME+ ++DR + ++GAKDIA+EVKK   KKV + +DR QDEY++RSYSRF++E+DDDD+  
Sbjct: 1   MEEGFRDRAAFIRGAKDIAKEVKKHAAKKVVKGLDRVQDEYSRRSYSRFEEEDDDDDFPA 60

Query: 60  PAGETYNGEANDDE----GSSEATEGHDEDDEIYEGEYQGIPSMNQA-KDSIVSVGQP-- 112
           P+   Y GE   DE     SS+ATEGHDEDDEIYEGEYQGIP      K   ++ G P  
Sbjct: 61  PSDGYYRGEGTQDEEEGGASSDATEGHDEDDEIYEGEYQGIPRAESGGKGERMADGAPLA 120

Query: 113 ------KGDEYKDRRELESERRADEEELAQQYELIIQECGHGRFQWALFFVLGMALMADG 166
                    E       E++RR + EELAQQYE I++ECGHGRFQW L+FVLG+ALMADG
Sbjct: 121 GVRGGLSDGEGPPGGRGEAQRRKEREELAQQYEAILRECGHGRFQWTLYFVLGLALMADG 180

Query: 167 VEVFVVGFVLPSAETDLCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRKQSLLICMS 226
           VEVFVVGFVLPSAE D+C+ +S  G LG IVYLGMMVGAF WGGLAD++GR+Q LLI +S
Sbjct: 181 VEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRLGRRQCLLISLS 240

Query: 227 VNGFFAFLSSFVQGYGFFLFCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFW 286
           VN  FAF SSFVQGYG FLFCRLLSG GIGG+IP VFSYF+E LA+EKRGEHLSWLCMFW
Sbjct: 241 VNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFW 300

Query: 287 MIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRF 346
           MIGG+YA+AMAWAIIPHYGWSF MGSAYQFHSWRVFV+VCA P V ++ ALT  PESPRF
Sbjct: 301 MIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALTTQPESPRF 360

Query: 347 LLEVGKHDEAWMILKLIHDTNMRARGQPEKVFTVNKIKTPKQIDELIEIESDTGTWYRRC 406
            LE GKHDEAWM+LK +HDTNMRA+G PE+VF+V  IKT  Q DELIEI+SDTGTWY+R 
Sbjct: 361 FLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVTHIKTIHQEDELIEIQSDTGTWYQRW 420

Query: 407 FVRIRTELYGIWLTFMRCFNYPVRDNTIKLTIVWFTLSFGYYGLSVWFPDVIKPLQSDEY 466
            VR  +    +W  F+ CF    R  T+ +  VWFT+SF YYGL+VWFPD+I+ LQ+ +Y
Sbjct: 421 GVRALSLGGQVWGNFLSCFGPEYRRITLMMMGVWFTMSFSYYGLTVWFPDMIRHLQAVDY 480

Query: 467 ALLTRNVERDKYANFTINFTMENQIHTGMEYDNGRFIGVKFKSVTFKDSVFKSCTFEDVT 526
           A  T+    ++  + T NFT+ENQIH G +Y N +FIG++ KSV+F+DS+F+ C FEDVT
Sbjct: 481 ASRTKVFPGERVEHVTFNFTLENQIHRGGQYFNDKFIGLRLKSVSFEDSLFEECYFEDVT 540

Query: 527 SVNTYFKNCTFIDTVFDNTDFEPYKFIDSEFKNCSFFHNKTGCQI-TFDDDYSAYWIYFV 585
           S NT+F+NCTFI+TVF NTD   YKF++S   N +F HNK GC +        AY +YFV
Sbjct: 541 SSNTFFRNCTFINTVFYNTDLFEYKFVNSRLINSTFLHNKEGCPLDVTGTGEGAYMVYFV 600

Query: 586 NFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNG 645
           +FLGTLAVLPGNIVSALLMD+IGRL ML GS V+S +SCFFL FG SES MI +LCL+ G
Sbjct: 601 SFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSESAMIALLCLFGG 660

Query: 646 LTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKSIPILLAS 705
           ++I++WN+LDV+TVELYP+D+R T FGFLNALCK AAVLG  IF S V ITK+ PIL AS
Sbjct: 661 VSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFAS 720

Query: 706 TVLVCGGLVGLCLPDTRTQVL 726
             L  G  + L LP+TR QVL
Sbjct: 721 AALALGSSLALKLPETRGQVL 741


>gi|7662270 synaptic vesicle protein 2B homolog [Homo sapiens]
          Length = 683

 Score =  847 bits (2189), Expect = 0.0
 Identities = 415/681 (60%), Positives = 509/681 (74%), Gaps = 3/681 (0%)

Query: 49  FQDEEDDDDYYPAGETYNG-EANDDEGS-SEATEGHDEDDEIYEGEYQGIPSMNQAKDSI 106
           ++ +++   Y P+   Y G E+N +E + S+ TEGHDE+DEIYEGEYQGIP  +  K   
Sbjct: 4   YKYQDNYGGYAPSDGYYRGNESNPEEDAQSDVTEGHDEEDEIYEGEYQGIPHPDDVKAKQ 63

Query: 107 VSVGQPKGDEYKDRRELESERRADEEELAQQYELIIQECGHGRFQWALFFVLGMALMADG 166
             +   + D  + + +L +ER  DEE+LA QYE I+ ECGHGRFQW LFFVLG+ALMADG
Sbjct: 64  AKMAPSRMDSLRGQTDLMAERLEDEEQLAHQYETIMDECGHGRFQWILFFVLGLALMADG 123

Query: 167 VEVFVVGFVLPSAETDLCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRKQSLLICMS 226
           VEVFVV F LPSAE D+C+ +S  G LG IVYLGMM GAF  GGLADK+GRK+ L + ++
Sbjct: 124 VEVFVVSFALPSAEKDMCLSSSKKGMLGMIVYLGMMAGAFILGGLADKLGRKRVLSMSLA 183

Query: 227 VNGFFAFLSSFVQGYGFFLFCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFW 286
           VN  FA LSSFVQGYG FLFCRL+SG GIGGA+P VF+YF+E L+REKRGEHLSWL +FW
Sbjct: 184 VNASFASLSSFVQGYGAFLFCRLISGIGIGGALPIVFAYFSEFLSREKRGEHLSWLGIFW 243

Query: 287 MIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRF 346
           M GG+YASAMAW+IIPHYGW FSMG+ Y FHSWRVFVIVCALPC  S+VAL FMPESPRF
Sbjct: 244 MTGGLYASAMAWSIIPHYGWGFSMGTNYHFHSWRVFVIVCALPCTVSMVALKFMPESPRF 303

Query: 347 LLEVGKHDEAWMILKLIHDTNMRARGQPEKVFTVNKIKTPKQIDELIEIESDTGTWYRRC 406
           LLE+GKHDEAWMILK +HDTNMRA+G PEKVFTV+ IKTPKQ+DE IEI+S TGTWY+R 
Sbjct: 304 LLEMGKHDEAWMILKQVHDTNMRAKGTPEKVFTVSNIKTPKQMDEFIEIQSSTGTWYQRW 363

Query: 407 FVRIRTELYGIWLTFMRCFNYPVRDNTIKLTIVWFTLSFGYYGLSVWFPDVIKPLQSDEY 466
            VR +T    +W   + C   P R NT+ L +VWF ++F YYGL+VWFPD+I+  Q +EY
Sbjct: 364 LVRFKTIFKQVWDNALYCVMGPYRMNTLILAVVWFAMAFSYYGLTVWFPDMIRYFQDEEY 423

Query: 467 ALLTRNVERDKYANFTINFTMENQIHTGMEYDNGRFIGVKFKSVTFKDSVFKSCTFEDVT 526
               +    +     TINFTMENQIH   +  N +F  + FK V F+D+ F  C FEDVT
Sbjct: 424 KSKMKVFFGEHVYGATINFTMENQIHQHGKLVNDKFTRMYFKHVLFEDTFFDECYFEDVT 483

Query: 527 SVNTYFKNCTFIDTVFDNTDFEPYKFIDSEFKNCSFFHNKTGCQITFDDDYSAYWIYFVN 586
           S +TYFKNCT   T+F NTD   +KFI+  F N +F   K GC +  + D + + IY V+
Sbjct: 484 STDTYFKNCTIESTIFYNTDLYEHKFINCRFINSTFLEQKEGCHMDLEQD-NDFLIYLVS 542

Query: 587 FLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGL 646
           FLG+L+VLPGNI+SALLMDRIGRL M+GGSM++S + CFFL+FG SES MIG  CL+ G 
Sbjct: 543 FLGSLSVLPGNIISALLMDRIGRLKMIGGSMLISAVCCFFLFFGNSESAMIGWQCLFCGT 602

Query: 647 TISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKSIPILLAST 706
           +I+AWN+LDV+TVELYPT++RAT FG LN LCK  A+LGN IF S V ITK +PILLA+ 
Sbjct: 603 SIAAWNALDVITVELYPTNQRATAFGILNGLCKFGAILGNTIFASFVGITKVVPILLAAA 662

Query: 707 VLVCGGLVGLCLPDTRTQVLM 727
            LV GGL+ L LP+TR QVLM
Sbjct: 663 SLVGGGLIALRLPETREQVLM 683


>gi|24308167 SV2 related protein [Homo sapiens]
          Length = 548

 Score =  123 bits (309), Expect = 5e-28
 Identities = 86/309 (27%), Positives = 142/309 (45%), Gaps = 48/309 (15%)

Query: 142 IQECGHGRFQWALFFVLGMALMADGVEVFVVGFVLPSAETDLCIPNSGSGWLGSIVYLGM 201
           ++  G G+FQW L  + G+A MAD +E+ ++  + P    +  +P+     L S+V++GM
Sbjct: 74  VEAIGFGKFQWKLSVLTGLAWMADAMEMMILSILAPQLHCEWRLPSWQVALLTSVVFVGM 133

Query: 202 MVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLFCRLLSGFGIGGAIPT 261
           M  +  WG ++D+ GRK  L I +    ++  LS+F   Y + L  R L GFGIGG +P 
Sbjct: 134 MSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPVYSWILVLRGLVGFGIGG-VPQ 192

Query: 262 VFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWRV 321
             + +AE L  + R + +  + +FW IG ++   +A  ++P  G             WR 
Sbjct: 193 SVTLYAEFLPMKARAKCILLIEVFWAIGTVFEVVLAVFVMPSLG-------------WRW 239

Query: 322 FVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQPEKVFTVN 381
            +I+ A+P +   V   ++PES R+ +  G  ++A   LK I   N    G P     + 
Sbjct: 240 LLILSAVPLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIATEN----GAP---MPLG 292

Query: 382 KIKTPKQIDELIEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYPVRDNTIKLTIVWF 441
           K+        +I  + D G                        F    R  T+ L  +WF
Sbjct: 293 KL--------IISRQEDRG-------------------KMRDLFTPHFRWTTLLLWFIWF 325

Query: 442 TLSFGYYGL 450
           + +F YYGL
Sbjct: 326 SNAFSYYGL 334



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 32/152 (21%), Positives = 64/152 (42%), Gaps = 8/152 (5%)

Query: 569 CQITFDDDY-SAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFL 627
           C+   ++DY    W        TL+  PG +V+  ++DR+GR   +    V+       L
Sbjct: 365 CEYLSEEDYMDLLWT-------TLSEFPGVLVTLWIIDRLGRKKTMALCFVIFSFCSLLL 417

Query: 628 WFGTSESMMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNL 687
           +     +++  +L +        + +  V T E+YPT  RA G G  + + +  A++   
Sbjct: 418 FICVGRNVLTLLLFIARAFISGGFQAAYVYTPEVYPTATRALGLGTCSGMARVGALITPF 477

Query: 688 IFGSLVSITKSIPILLASTVLVCGGLVGLCLP 719
           I   ++  +  + + + S   +   L    LP
Sbjct: 478 IAQVMLESSVYLTLAVYSGCCLLAALASCFLP 509


>gi|213021148 SVOP-like isoform 1 [Homo sapiens]
          Length = 492

 Score =  103 bits (257), Expect = 6e-22
 Identities = 78/311 (25%), Positives = 134/311 (43%), Gaps = 52/311 (16%)

Query: 142 IQECGHGRFQWALFFVLGMALMADGVEVFVVGFVLPSAETDLCIPNSGSGWLGSIVYLGM 201
           ++  G GRF  ALF ++G   + + +E+ ++  V P    +  + N     + ++V+ G 
Sbjct: 38  VETIGFGRFHIALFLIMGSTGVVEAMEIMLIAVVSPVIRCEWQLENWQVALVTTMVFFGY 97

Query: 202 MVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLFCRLLSGFGIGGAIPT 261
           MV +  +G LAD+ GR + LLI      +F+ L+SF   Y +F+F R + G G+ G    
Sbjct: 98  MVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGHSQG 157

Query: 262 VFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWRV 321
           +     E L  + RG  L    +FW+ G +    +A  IIP  G             WR 
Sbjct: 158 LI-IKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIG-------------WRW 203

Query: 322 FVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQPEKVFTVN 381
            + V ++P +  +VA  F+PES RF +  G    A   L              E+V  +N
Sbjct: 204 LIRVASIPGIILIVAFKFIPESARFNVSTGNTRAALATL--------------ERVAKMN 249

Query: 382 KIKTP--KQIDELIEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYPVRDNTIKLTIV 439
           +   P  K ++ ++E            ++R                       T+++ ++
Sbjct: 250 RSVMPEGKLVEPVLEKRGRFADLLDAKYLR----------------------TTLQIWVI 287

Query: 440 WFTLSFGYYGL 450
           W  +SF YYG+
Sbjct: 288 WLGISFAYYGV 298



 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 40/142 (28%), Positives = 70/142 (49%), Gaps = 3/142 (2%)

Query: 578 SAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMI 637
           S Y    ++ +G +A+ P NI+    ++ +GR   L  +M  + +    L   TS + +I
Sbjct: 342 SDYRTMIISTIGEIALNPLNILG---INFLGRRLSLSITMGCTALFFLLLNICTSSAGLI 398

Query: 638 GMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITK 697
           G L +   L  + +N++ + T E+YPT  RA G G   +LC+  A++   I   L+S + 
Sbjct: 399 GFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASI 458

Query: 698 SIPILLASTVLVCGGLVGLCLP 719
              + L S+V V   +    LP
Sbjct: 459 LGALCLFSSVCVVCAISAFTLP 480


>gi|4507005 solute carrier family 22 member 5 [Homo sapiens]
          Length = 557

 Score = 90.1 bits (222), Expect = 6e-18
 Identities = 68/263 (25%), Positives = 121/263 (46%), Gaps = 41/263 (15%)

Query: 195 SIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLFCRLLSGFG 254
           S+ ++G+++G+F  G L+D+ GRK  L + M +   F+FL  F + +  F+   +L G G
Sbjct: 147 SLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMG 206

Query: 255 IGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAY 314
                   F    E+L +  R        +F  +G     A  + ++P +        AY
Sbjct: 207 QISNYVAAFVLGTEILGKSVR-------IIFSTLGVCIFYAFGYMVLPLF--------AY 251

Query: 315 QFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQP 374
               WR+ ++   +P V  V    F+PESPR+L+  G+ +EA +I++             
Sbjct: 252 FIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIR------------- 298

Query: 375 EKVFTVNKIKTPKQIDELIEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYPVRDNTI 434
            K    N I  P  I +  E++  +           + + + I L  +R +N  +R  TI
Sbjct: 299 -KAAKANGIVVPSTIFDPSELQDLSSK---------KQQSHNI-LDLLRTWN--IRMVTI 345

Query: 435 KLTIVWFTLSFGYYGLSVWFPDV 457
              ++W T+S GY+GLS+  P++
Sbjct: 346 MSIMLWMTISVGYFGLSLDTPNL 368



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 36/146 (24%), Positives = 72/146 (49%), Gaps = 14/146 (9%)

Query: 584 FVN-FLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFF-------LWFGTSESM 635
           FVN FL  +  +P  +++ LL+  + R   +  ++ L G    F       L++  +  +
Sbjct: 373 FVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLV 432

Query: 636 MIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSI 695
           M+G      G+T +A++ + V T ELYPT  R  G G  +   +  ++L +  F  L + 
Sbjct: 433 MVGKF----GVT-AAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSIL-SPYFVYLGAY 486

Query: 696 TKSIPILLASTVLVCGGLVGLCLPDT 721
            + +P +L  ++ +   ++ L LP++
Sbjct: 487 DRFLPYILMGSLTILTAILTLFLPES 512


>gi|24497490 solute carrier family 22 member 4 [Homo sapiens]
          Length = 551

 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 64/263 (24%), Positives = 110/263 (41%), Gaps = 43/263 (16%)

Query: 195 SIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLFCRLLSGFG 254
           S+ ++G+++G+F  G L+D+ GRK  L   M+V   F+FL  F   +  F    ++ G G
Sbjct: 147 SLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQTGFSFLQIFSISWEMFTVLFVIVGMG 206

Query: 255 IGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAY 314
                   F    E+L +  R        +F  +G     A+ + ++P +        AY
Sbjct: 207 QISNYVVAFILGTEILGKSVR-------IIFSTLGVCTFFAVGYMLLPLF--------AY 251

Query: 315 QFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQP 374
               WR+ ++   +P V  V    F+PESPR+L+   +  EA  I+              
Sbjct: 252 FIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDII-------------- 297

Query: 375 EKVFTVNKIKTPKQIDELIEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYPVRDNTI 434
           +K   +N I  P  I +   +E       ++ F+          L   R  N  +   TI
Sbjct: 298 QKAAKMNNIAVPAVIFD--SVEELNPLKQQKAFI----------LDLFRTRNIAIM--TI 343

Query: 435 KLTIVWFTLSFGYYGLSVWFPDV 457
              ++W   S GY+ LS+  P++
Sbjct: 344 MSLLLWMLTSVGYFALSLDAPNL 366



 Score = 38.5 bits (88), Expect = 0.022
 Identities = 33/141 (23%), Positives = 63/141 (44%), Gaps = 3/141 (2%)

Query: 583 YFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSES--MMIGML 640
           Y   FL  L  +P  I + LL+  + R  ++   +   G    F+     +   + IG++
Sbjct: 371 YLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVPVDYYFLSIGLV 430

Query: 641 CLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKSIP 700
            L      SA++ L V T ELYPT  R    G  +   +  +++    F  L +  + +P
Sbjct: 431 MLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAP-YFVYLGAYNRMLP 489

Query: 701 ILLASTVLVCGGLVGLCLPDT 721
            ++  ++ V  G++ L  P++
Sbjct: 490 YIVMGSLTVLIGILTLFFPES 510


>gi|24497497 solute carrier family 22 member 7 isoform a [Homo
           sapiens]
          Length = 546

 Score = 69.7 bits (169), Expect = 9e-12
 Identities = 67/277 (24%), Positives = 106/277 (38%), Gaps = 43/277 (15%)

Query: 178 SAETDLCIPNSGSGWLGSIVYL-GMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSS 236
           + E DL     G     S  +  G++VGA  +G L+D+ GR++ LL+           S+
Sbjct: 129 ATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVSTLVLGLASA 188

Query: 237 FVQGYGFFLFCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAM 296
               Y  F   R L+G  + G    V     E L  E R         FW  GG+   A+
Sbjct: 189 ASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFWT-GGVMLLAL 247

Query: 297 AWAIIPHYGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEA 356
                            Y    WR  ++   LPC   +++L ++PES R+LL  G   EA
Sbjct: 248 V---------------GYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEA 292

Query: 357 WMILKLIHDTNMRARGQPEKVFTVNKIKTPKQIDELIEIESDTGTWYRRCFVRIRTELYG 416
                L+H   +  R   E  F+   +      + ++   S                   
Sbjct: 293 HRY--LLHCARLNGRPVCEDSFSQEAVSKVAAGERVVRRPS------------------- 331

Query: 417 IWLTFMRCFNYP-VRDNTIKLTIVWFTLSFGYYGLSV 452
               ++  F  P +R  ++   +VWF ++F YYGLS+
Sbjct: 332 ----YLDLFRTPRLRHISLCCVVVWFGVNFSYYGLSL 364



 Score = 32.0 bits (71), Expect = 2.1
 Identities = 34/148 (22%), Positives = 59/148 (39%), Gaps = 13/148 (8%)

Query: 582 IYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTS-------ES 634
           +Y    L     LP  ++  L +   GR     G+++ + ++     FGT        +S
Sbjct: 373 VYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALA-----FGTRLLVSSDMKS 427

Query: 635 MMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVS 694
               +  +    + +A+ +  + T ELYPT  R TG G    + +    L  L    L  
Sbjct: 428 WSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSLAPLA-ALLDG 486

Query: 695 ITKSIPILLASTVLVCGGLVGLCLPDTR 722
           +  S+P L    + +      L LP+TR
Sbjct: 487 VWLSLPKLTYGGIALLAAGTALLLPETR 514


>gi|90669191 solute carrier family 22 member 7 isoform b [Homo
           sapiens]
          Length = 548

 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 62/256 (24%), Positives = 100/256 (39%), Gaps = 42/256 (16%)

Query: 198 YLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLFCRLLSGFGIGG 257
           + G++VGA  +G L+D+ GR++ LL+           S+    Y  F   R L+G  + G
Sbjct: 152 FAGVLVGAVAFGYLSDRFGRRRLLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAG 211

Query: 258 AIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFH 317
               V     E L  E R         FW  GG+   A+                 Y   
Sbjct: 212 FTIIVMPLELEWLDVEHRTVAGVLSSTFWT-GGVMLLALV---------------GYLIR 255

Query: 318 SWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQPEKV 377
            WR  ++   LPC   +++L ++PES R+LL  G   EA     L+H   +  R   E  
Sbjct: 256 DWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRY--LLHCARLNGRPVCEDS 313

Query: 378 FTVNKIKTPKQIDELIEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYP-VRDNTIKL 436
           F+   +      + ++   S                       ++  F  P +R  ++  
Sbjct: 314 FSQEAVSKVAAGERVVRRPS-----------------------YLDLFRTPRLRHISLCC 350

Query: 437 TIVWFTLSFGYYGLSV 452
            +VWF ++F YYGLS+
Sbjct: 351 VVVWFGVNFSYYGLSL 366



 Score = 32.0 bits (71), Expect = 2.1
 Identities = 34/148 (22%), Positives = 59/148 (39%), Gaps = 13/148 (8%)

Query: 582 IYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTS-------ES 634
           +Y    L     LP  ++  L +   GR     G+++ + ++     FGT        +S
Sbjct: 375 VYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALA-----FGTRLLVSSDMKS 429

Query: 635 MMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVS 694
               +  +    + +A+ +  + T ELYPT  R TG G    + +    L  L    L  
Sbjct: 430 WSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSLAPLA-ALLDG 488

Query: 695 ITKSIPILLASTVLVCGGLVGLCLPDTR 722
           +  S+P L    + +      L LP+TR
Sbjct: 489 VWLSLPKLTYGGIALLAAGTALLLPETR 516


>gi|21361449 solute carrier family 2 (facilitated glucose
           transporter), member 8 [Homo sapiens]
          Length = 477

 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 50/181 (27%), Positives = 79/181 (43%), Gaps = 21/181 (11%)

Query: 185 IPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRKQSLLICM--SVNGFFAFLSSFVQGYG 242
           + ++ + W G++V LG   G    G L D+ GRK SLL+C    V GF    ++  Q   
Sbjct: 64  LDDAAASWFGAVVTLGAAAGGVLGGWLVDRAGRKLSLLLCSVPFVAGFAVITAA--QDVW 121

Query: 243 FFLFCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIP 302
             L  RLL+G   G A      Y +E+     RG   S + +  ++G + A    W +  
Sbjct: 122 MLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVVGILLAYLAGWVL-- 179

Query: 303 HYGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKL 362
                           WR   ++  +P    ++ + FMPE+PRFLL   +  EA   L+ 
Sbjct: 180 ---------------EWRWLAVLGCVPPSLMLLLMCFMPETPRFLLTQHRRQEAMAALRF 224

Query: 363 I 363
           +
Sbjct: 225 L 225


>gi|166197673 solute carrier family 22, member 15 [Homo sapiens]
          Length = 547

 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 68/259 (26%), Positives = 96/259 (37%), Gaps = 48/259 (18%)

Query: 195 SIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLFCRLLSGFG 254
           S  + G+ VG   +G L+D+ GRK+  L   +++  FA  + F   Y FF   R L G  
Sbjct: 116 SFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIANGFSPSYEFFAVTRFLVGMM 175

Query: 255 IGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAY 314
            GG      S  A VL  E  G        +W + G          I  Y         Y
Sbjct: 176 NGG-----MSLVAFVLLNECVG------TAYWALAGSIGGLFFAVGIAQYAL-----LGY 219

Query: 315 QFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQP 374
              SWR   I+  L      +   F+PESPR+L   G+  EA   L LI   N + +   
Sbjct: 220 FIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALYLIAKRNRKLKCTF 279

Query: 375 EKVFTVNKIKTPKQIDELIEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYPV-RDNT 433
                 N+               +TG                   +F+  F Y V   +T
Sbjct: 280 SLTHPANRSC------------RETG-------------------SFLDLFRYRVLLGHT 308

Query: 434 IKLTIVWFTLSFGYYGLSV 452
           + L  +WF  S  YYGL++
Sbjct: 309 LILMFIWFVCSLVYYGLTL 327



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 37/128 (28%), Positives = 57/128 (44%), Gaps = 9/128 (7%)

Query: 608 GRLTMLGGSMVLSGISCFFLWF-------GTSESMMIGMLCLYNGLTISA-WNSLDVVTV 659
           GR   L   + L G++C  + F       G    +    L L   LTISA +N + + T 
Sbjct: 364 GRKRTLSAFLCLGGLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTS 423

Query: 660 ELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKSIPILLASTVLVCGGLVGLCLP 719
           ELYPT  R  G G  +   +   ++   I  SL  +  S+P ++     +  GL+ L LP
Sbjct: 424 ELYPTVIRNVGLGTCSMFSRVGGIIAPFI-PSLKYVQWSLPFIVFGATGLTSGLLSLLLP 482

Query: 720 DTRTQVLM 727
           +T    L+
Sbjct: 483 ETLNSPLL 490


>gi|166064021 solute carrier family 22 (organic anion transporter),
           member 13 [Homo sapiens]
          Length = 551

 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 62/264 (23%), Positives = 108/264 (40%), Gaps = 50/264 (18%)

Query: 195 SIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLFCRLLSGFG 254
           S+   G++VG   +G L D++GRK ++L  + +       ++FV  +  ++  R      
Sbjct: 142 SVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIGLATAFVPSFELYMALRFAVATA 201

Query: 255 IGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAY 314
           + G      S+    L  E       W+   W    +  +   +++    G     G AY
Sbjct: 202 VAG-----LSFSNVTLLTE-------WVGPSWRTQAVVLAQCNFSL----GQMVLAGLAY 245

Query: 315 QFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQP 374
            F +WR+  I    P +        +PES R+LL  G+ DEA  ++              
Sbjct: 246 GFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLI-------------- 291

Query: 375 EKVFTVNKIK-TPKQIDELIEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYP-VRDN 432
           +K  +VN+ K +P+ +++L+                   E  G     +  F +P +R  
Sbjct: 292 QKAASVNRRKLSPELMNQLVP------------------EKTGPSGNALDLFRHPQLRKV 333

Query: 433 TIKLTIVWFTLSFGYYGLSVWFPD 456
           T+ +  VWF  S GYYGLS+   D
Sbjct: 334 TLIIFCVWFVDSLGYYGLSLQVGD 357



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 38/147 (25%), Positives = 70/147 (47%), Gaps = 3/147 (2%)

Query: 582 IYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSE-SMMIGML 640
           +Y    +     +P    S  +M R GR     G++VL G+ C  + F  ++  +++ ML
Sbjct: 362 VYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIFIPADLPVVVTML 421

Query: 641 CLYNGL-TISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKSI 699
            +   + T +A+    V + EL+PT  R TG G +    +   +L  L+   L     ++
Sbjct: 422 AVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGILTPLVI-LLGEYHAAL 480

Query: 700 PILLASTVLVCGGLVGLCLPDTRTQVL 726
           P+L+  ++ +  GL+   LP+T  Q L
Sbjct: 481 PMLIYGSLPIVAGLLCTLLPETHGQGL 507


>gi|223029432 solute carrier family 2 (facilitated glucose
           transporter), member 6 isoform 1 [Homo sapiens]
          Length = 507

 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 50/200 (25%), Positives = 83/200 (41%), Gaps = 17/200 (8%)

Query: 178 SAETDLCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSF 237
           S + DL +  S + W GS+  LG   G      L D +GRK S++     +     L + 
Sbjct: 69  SLDPDLHLTKSQASWFGSVFTLGAAAGGLSAMILNDLLGRKLSIMFSAVPSAAGYALMAG 128

Query: 238 VQGYGFFLFCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMA 297
             G    L  R L+GF  G     +  Y +E+     RG   +   +  + G +   A+ 
Sbjct: 129 AHGLWMLLLGRTLTGFAGGLTAACIPVYVSEIAPPGVRGALGATPQLMAVFGSLSLYALG 188

Query: 298 WAIIPHYGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAW 357
             ++P                WR   +    P +  ++ L+FMP SPRFLL  G+ +EA 
Sbjct: 189 -LLLP----------------WRWLAVAGEAPVLIMILLLSFMPNSPRFLLSRGRDEEAL 231

Query: 358 MILKLIHDTNMRARGQPEKV 377
             L  +  T++    + E++
Sbjct: 232 RALAWLRGTDVDVHWEFEQI 251


>gi|223029430 solute carrier family 2 (facilitated glucose
           transporter), member 6 isoform 2 [Homo sapiens]
          Length = 445

 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 50/200 (25%), Positives = 83/200 (41%), Gaps = 17/200 (8%)

Query: 178 SAETDLCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSF 237
           S + DL +  S + W GS+  LG   G      L D +GRK S++     +     L + 
Sbjct: 69  SLDPDLHLTKSQASWFGSVFTLGAAAGGLSAMILNDLLGRKLSIMFSAVPSAAGYALMAG 128

Query: 238 VQGYGFFLFCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMA 297
             G    L  R L+GF  G     +  Y +E+     RG   +   +  + G +   A+ 
Sbjct: 129 AHGLWMLLLGRTLTGFAGGLTAACIPVYVSEIAPPGVRGALGATPQLMAVFGSLSLYALG 188

Query: 298 WAIIPHYGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAW 357
             ++P                WR   +    P +  ++ L+FMP SPRFLL  G+ +EA 
Sbjct: 189 -LLLP----------------WRWLAVAGEAPVLIMILLLSFMPNSPRFLLSRGRDEEAL 231

Query: 358 MILKLIHDTNMRARGQPEKV 377
             L  +  T++    + E++
Sbjct: 232 RALAWLRGTDVDVHWEFEQI 251


>gi|157426885 organic cation transporter like 4 [Homo sapiens]
          Length = 594

 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 77/335 (22%), Positives = 141/335 (42%), Gaps = 64/335 (19%)

Query: 135 AQQYELIIQECGHGRFQWALFFVLGMALMADGVEVFVV--------GFVLPSA------- 179
           A+Q  L I +  +G F    F  L +    D +  F +        G++ P A       
Sbjct: 113 AEQLNLTIPQAPNGSFL-TCFMYLPVPWNLDSIIQFGLNDTDTCQDGWIYPDAKKRSLIN 171

Query: 180 ETDLCIPNSGSGWLGSIVYL-GMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFV 238
           E DL            I+++ G+ +G+  +  + DK+GR  ++L+ +     F F ++F+
Sbjct: 172 EFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSLLGLIIFGFGTAFM 231

Query: 239 QGYGFFLFCRL-LSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMA 297
             +  +LF R  +S   +G AI ++ S   E L  E R   +     F+ +G +  + +A
Sbjct: 232 NSFHLYLFFRFGISQSVVGYAISSI-SLATEWLVGEHRAHAIILGHCFFAVGAVLLTGIA 290

Query: 298 WAIIPHYGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAW 357
           ++ +PH               W++  +V  +  +  +  +  +PESPR+L+  GK  EA 
Sbjct: 291 YS-LPH---------------WQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAK 334

Query: 358 MILKLIHDTNMRARGQPEKVFTVNKIKTPKQIDELIEIESDTGTWYRRCFVRIRTELYGI 417
            +L                  +VNK   P  + + +++     T   R  V         
Sbjct: 335 QVLCY--------------AASVNKKTIPSNLLDELQLPRKKVT---RASV--------- 368

Query: 418 WLTFMRCFNYPVRDNTIKLTIVWFTLSFGYYGLSV 452
            L F  C N  +   T+ ++ VWFT+S+ Y+ LS+
Sbjct: 369 -LDF--CKNRQLCKVTLVMSCVWFTVSYTYFTLSL 400



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 40/162 (24%), Positives = 67/162 (41%), Gaps = 20/162 (12%)

Query: 582 IYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTS--------- 632
           ++F + + ++  +P  +    L+ +IGR   L  +++ + I C  L F            
Sbjct: 409 VHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLLLFLPEGEDGLRLKW 468

Query: 633 --------ESMMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVL 684
                   +SM I +L L      +      + T EL PT  RATG G ++    A A+L
Sbjct: 469 PRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRATGLGLVSLASVAGAIL 528

Query: 685 GNLIFGSLVSITKSIPILLASTVLVCGGLVGLCLPDTRTQVL 726
              I     S+   +PI L   + +    +   LP+TR Q L
Sbjct: 529 SLTIISQTPSL---LPIFLCCVLAIVAFSLSSLLPETRDQPL 567


>gi|11415038 solute carrier family 22 member 3 [Homo sapiens]
          Length = 556

 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 39/150 (26%), Positives = 75/150 (50%), Gaps = 16/150 (10%)

Query: 582 IYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCF--------FLWFGTSE 633
           +Y   F+  +  LPG ++  L ++R+GR      S +++G++C           W  T+ 
Sbjct: 379 LYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAGVACLVTAFLPEGIAWLRTTV 438

Query: 634 SMMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLV 693
           + + G L    G+T+ A+  + +V  ELYPT  R  G    + LC    ++   +   L 
Sbjct: 439 ATL-GRL----GITM-AFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLA 492

Query: 694 SITKSIPILLASTVL-VCGGLVGLCLPDTR 722
           ++   +P+++   +  +CGGLV + LP+T+
Sbjct: 493 AVWLELPLIIFGILASICGGLV-MLLPETK 521



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 54/199 (27%), Positives = 87/199 (43%), Gaps = 20/199 (10%)

Query: 195 SIVYLGMMVGAFFWGGLADKVGR-KQSLLICMSVNGFFAFLSSFVQGYGFFLFCRLLSGF 253
           +I+ LG + GAF  G  AD+ GR    LL C+ V G    + +F   +  F+  R L G 
Sbjct: 159 AILNLGFLTGAFTLGYAADRYGRIVIYLLSCLGV-GVTGVVVAFAPNFPVFVIFRFLQGV 217

Query: 254 GIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSA 313
              G   T +    E++  ++R      + MF+ +G I        I+P        G A
Sbjct: 218 FGKGTWMTCYVIVTEIVGSKQRRIVGIVIQMFFTLGII--------ILP--------GIA 261

Query: 314 YQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMR--AR 371
           Y   +W+   +   LP    ++    +PESPR+L+   K D+A  IL+ I   N +  + 
Sbjct: 262 YFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKGDKALQILRRIAKCNGKYLSS 321

Query: 372 GQPEKVFTVNKIKTPKQID 390
              E   T  ++  P  +D
Sbjct: 322 NYSEITVTDEEVSNPSFLD 340


>gi|4506999 solute carrier family 22 member 1 isoform a [Homo
           sapiens]
          Length = 554

 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 37/143 (25%), Positives = 76/143 (53%), Gaps = 5/143 (3%)

Query: 584 FVNFL-GTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCL 642
           +++FL   L  +PG  ++ + +DR+GR+  +  S +L+G +C  + F + +   + ++ +
Sbjct: 376 YLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIFISPDLHWLNIIIM 435

Query: 643 ---YNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKSI 699
                G+TI A   + +V  ELYPT  R  G    ++LC    ++   I   L  + +++
Sbjct: 436 CVGRMGITI-AIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPFIVFRLREVWQAL 494

Query: 700 PILLASTVLVCGGLVGLCLPDTR 722
           P++L + + +    V L LP+T+
Sbjct: 495 PLILFAVLGLLAAGVTLLLPETK 517



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 65/257 (25%), Positives = 98/257 (38%), Gaps = 46/257 (17%)

Query: 195 SIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLFCRLLSGFG 254
           S +  G + G+   G  AD+ GRK  LL  + VN     L +F   Y   L  RLL G  
Sbjct: 153 SCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLV 212

Query: 255 IGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAY 314
             G     ++   E +    R        M + +G +  + +A+A+ PH           
Sbjct: 213 SKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTVGLVALTGLAYAL-PH----------- 260

Query: 315 QFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQP 374
               WR   +  +LP    ++    +PESPR+LL   ++ EA  I+  I   N       
Sbjct: 261 ----WRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNG------ 310

Query: 375 EKVFTVNKIKTPKQIDELIEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYP-VRDNT 433
                    K P    +++ +E D             TE   +  +F   F  P +R  T
Sbjct: 311 ---------KLPPADLKMLSLEEDV------------TE--KLSPSFADLFRTPRLRKRT 347

Query: 434 IKLTIVWFTLSFGYYGL 450
             L  +WFT S  Y GL
Sbjct: 348 FILMYLWFTDSVLYQGL 364


>gi|4507001 solute carrier family 22 member 2 [Homo sapiens]
          Length = 555

 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 63/257 (24%), Positives = 101/257 (39%), Gaps = 46/257 (17%)

Query: 195 SIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLFCRLLSGFG 254
           S V +G  +G+   G +AD+ GRK  LL  + +N     L +    Y + L  RL+ G  
Sbjct: 154 SSVNVGFFIGSMSIGYIADRFGRKLCLLTTVLINAAAGVLMAISPTYTWMLIFRLIQGLV 213

Query: 255 IGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAY 314
                   +    E + R  R     +  + + +G +  + +A+A+ PH           
Sbjct: 214 SKAGWLIGYILITEFVGRRYRRTVGIFYQVAYTVGLLVLAGVAYAL-PH----------- 261

Query: 315 QFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQP 374
               WR      ALP    ++    +PESPR+L+   K+ EA  I+K I   N ++    
Sbjct: 262 ----WRWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNAEAMRIIKHIAKKNGKS---- 313

Query: 375 EKVFTVNKIKTPKQIDELIEIESDTGTWYRRCFV-RIRTELYGIWLTFMRCFNYPVRDNT 433
                      P  +  L  +E +TG      F+  +RT                +R +T
Sbjct: 314 ----------LPASLQRL-RLEEETGKKLNPSFLDLVRTP--------------QIRKHT 348

Query: 434 IKLTIVWFTLSFGYYGL 450
           + L   WFT S  Y GL
Sbjct: 349 MILMYNWFTSSVLYQGL 365



 Score = 56.6 bits (135), Expect = 8e-08
 Identities = 43/148 (29%), Positives = 70/148 (47%), Gaps = 4/148 (2%)

Query: 582 IYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWF--GTSESMMIGM 639
           IY   F   L   P   +  L +DRIGR      S +++G +C    F  G  + + I +
Sbjct: 376 IYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLASVFIPGDLQWLKIII 435

Query: 640 LCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKSI 699
            CL       A+  + +V  ELYPT  R  G    +++C    ++   +   L +I   +
Sbjct: 436 SCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGIITPFLVYRLTNIWLEL 495

Query: 700 PILLASTV-LVCGGLVGLCLPDTRTQVL 726
           P+++   + LV GGLV L LP+T+ + L
Sbjct: 496 PLMVFGVLGLVAGGLV-LLLPETKGKAL 522


>gi|33457322 SVOP-like isoform 2 [Homo sapiens]
          Length = 340

 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 40/142 (28%), Positives = 70/142 (49%), Gaps = 3/142 (2%)

Query: 578 SAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMI 637
           S Y    ++ +G +A+ P NI+    ++ +GR   L  +M  + +    L   TS + +I
Sbjct: 190 SDYRTMIISTIGEIALNPLNILG---INFLGRRLSLSITMGCTALFFLLLNICTSSAGLI 246

Query: 638 GMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITK 697
           G L +   L  + +N++ + T E+YPT  RA G G   +LC+  A++   I   L+S + 
Sbjct: 247 GFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASI 306

Query: 698 SIPILLASTVLVCGGLVGLCLP 719
              + L S+V V   +    LP
Sbjct: 307 LGALCLFSSVCVVCAISAFTLP 328



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 42/185 (22%), Positives = 70/185 (37%), Gaps = 51/185 (27%)

Query: 268 EVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWRVFVIVCA 327
           E L  + RG  L    +FW+ G +    +A  IIP  GW             R  + V +
Sbjct: 11  EFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGW-------------RWLIRVAS 57

Query: 328 LPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQPEKVFTVNKIKTP- 386
           +P +  +VA  F+PES RF +  G    A   L              E+V  +N+   P 
Sbjct: 58  IPGIILIVAFKFIPESARFNVSTGNTRAALATL--------------ERVAKMNRSVMPE 103

Query: 387 -KQIDELIEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYPVRDNTIKLTIVWFTLSF 445
            K ++ ++E            ++R                       T+++ ++W  +SF
Sbjct: 104 GKLVEPVLEKRGRFADLLDAKYLR----------------------TTLQIWVIWLGISF 141

Query: 446 GYYGL 450
            YYG+
Sbjct: 142 AYYGV 146


>gi|31542327 solute carrier family 22, member 16 [Homo sapiens]
          Length = 577

 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 50/265 (18%), Positives = 109/265 (41%), Gaps = 42/265 (15%)

Query: 192 WLGSIVY----LGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLFC 247
           WL  ++      G+++G+  +G  +D++GR+  L    S    F   ++F   Y  F+  
Sbjct: 152 WLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAA 211

Query: 248 RLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWS 307
           R        G +   F Y  E +  + R      L  F+ +G +  +             
Sbjct: 212 RFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVAL------------ 259

Query: 308 FSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTN 367
               + Y   +W ++ ++ +   V  ++    +PE+P +LL  G+++EA  I+ ++   N
Sbjct: 260 ----TGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQKIVDIMAKWN 315

Query: 368 MRARGQPEKVFTVNKIKTPKQIDELIEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNY 427
                            +  ++ EL+ ++       +       TE+    L+++  +N+
Sbjct: 316 R---------------ASSCKLSELLSLD------LQGPVSNSPTEVQKHNLSYL-FYNW 353

Query: 428 PVRDNTIKLTIVWFTLSFGYYGLSV 452
            +   T+ + ++WFT S G+Y  S+
Sbjct: 354 SITKRTLTVWLIWFTGSLGFYSFSL 378



 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 39/141 (27%), Positives = 69/141 (48%), Gaps = 3/141 (2%)

Query: 583 YFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCL 642
           Y   FL  +  +P      + MD++GR T+L  S+  S ++C  +     +  ++G++  
Sbjct: 388 YLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTA 447

Query: 643 YNGLTI--SAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKSIP 700
             G     +A+  + + T ELYPT  R+   G  + +C+ A++L       L SI   IP
Sbjct: 448 MVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSV-DLSSIWIFIP 506

Query: 701 ILLASTVLVCGGLVGLCLPDT 721
            L   T+ +  G++ L LP+T
Sbjct: 507 QLFVGTMALLSGVLTLKLPET 527


>gi|203098995 solute carrier family 2 (facilitated glucose
           transporter), member 13 [Homo sapiens]
          Length = 648

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 46/158 (29%), Positives = 70/158 (44%), Gaps = 11/158 (6%)

Query: 203 VGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLFCRLLSGFGIGGAIPTV 262
           V A   G L    GR+ ++L+  ++    + + +        L  RL+ G GIG A  TV
Sbjct: 133 VSALAGGALNGVFGRRAAILLASALFTAGSAVLAAANNKETLLAGRLVVGLGIGIASMTV 192

Query: 263 FSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWRVF 322
             Y AEV     RG  ++   +F   G  +AS +  A            S  Q   WR  
Sbjct: 193 PVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAF-----------SYLQKDGWRYM 241

Query: 323 VIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMIL 360
           + + A+P V       F+PESPR+L++ G+  +A  IL
Sbjct: 242 LGLAAVPAVIQFFGFLFLPESPRWLIQKGQTQKARRIL 279


>gi|8923870 solute carrier family 22 member 11 [Homo sapiens]
          Length = 550

 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 42/190 (22%), Positives = 82/190 (43%), Gaps = 17/190 (8%)

Query: 179 AETDLCIPNSGSGWLGSIVYL-GMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSF 237
           A+ DL   + G   L   +++ G++VG+F WG L+ + GRK  L  C          + F
Sbjct: 130 AKWDLVCSSQGLKPLSQSIFMSGILVGSFIWGLLSYRFGRKPMLSWCCLQLAVAGTSTIF 189

Query: 238 VQGYGFFLFCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMA 297
              +  +   R ++ FG+ G   +  +   E     +R   ++      ++G  +++   
Sbjct: 190 APTFVIYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMT------VVGCAFSA--- 240

Query: 298 WAIIPHYGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAW 357
                  G +   G A+    WR   +  ++P  +  +   ++PES R+L+  GK D+A 
Sbjct: 241 -------GQAALGGLAFALRDWRTLQLAASVPFFAISLISWWLPESARWLIIKGKPDQAL 293

Query: 358 MILKLIHDTN 367
             L+ +   N
Sbjct: 294 QELRKVARIN 303



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 38/137 (27%), Positives = 63/137 (45%), Gaps = 12/137 (8%)

Query: 596 GNIVSALLMDRIGRLTMLGGSMVLSGISCF--FLWFGTSESMMIGMLCLYNGLTISAWNS 653
           G   +ALL+  +GR T+  GS  ++G++     L     +++ +    L  G    +   
Sbjct: 388 GRATTALLLSFLGRRTIQAGSQAMAGLAILANMLVPQDLQTLRVVFAVLGKGCFGISLTC 447

Query: 654 LDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKSIPILLASTVLVCGGL 713
           L +   EL+PT  R T  G L+ + +  A++G LI  S  ++   +P LL   + +   L
Sbjct: 448 LTIYKAELFPTPVRMTADGILHTVGRLGAMMGPLILMSRQAL-PLLPPLLYGVISIASSL 506

Query: 714 V---------GLCLPDT 721
           V         GL LPDT
Sbjct: 507 VVLFFLPETQGLPLPDT 523


>gi|23510410 solute carrier family 22 member 1 isoform b [Homo
           sapiens]
          Length = 506

 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 65/257 (25%), Positives = 98/257 (38%), Gaps = 46/257 (17%)

Query: 195 SIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLFCRLLSGFG 254
           S +  G + G+   G  AD+ GRK  LL  + VN     L +F   Y   L  RLL G  
Sbjct: 153 SCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLV 212

Query: 255 IGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAY 314
             G     ++   E +    R        M + +G +  + +A+A+ PH           
Sbjct: 213 SKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTVGLVALTGLAYAL-PH----------- 260

Query: 315 QFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQP 374
               WR   +  +LP    ++    +PESPR+LL   ++ EA  I+  I   N       
Sbjct: 261 ----WRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNG------ 310

Query: 375 EKVFTVNKIKTPKQIDELIEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYP-VRDNT 433
                    K P    +++ +E D             TE   +  +F   F  P +R  T
Sbjct: 311 ---------KLPPADLKMLSLEEDV------------TE--KLSPSFADLFRTPRLRKRT 347

Query: 434 IKLTIVWFTLSFGYYGL 450
             L  +WFT S  Y GL
Sbjct: 348 FILMYLWFTDSVLYQGL 364



 Score = 39.3 bits (90), Expect = 0.013
 Identities = 24/85 (28%), Positives = 48/85 (56%), Gaps = 5/85 (5%)

Query: 584 FVNFL-GTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCL 642
           +++FL   L  +PG  ++ + +DR+GR+  +  S +L+G +C  + F + +   + ++ +
Sbjct: 376 YLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIFISPDLHWLNIIIM 435

Query: 643 ---YNGLTISAWNSLDVVTVELYPT 664
                G+TI A   + +V  ELYPT
Sbjct: 436 CVGRMGITI-AIQMICLVNAELYPT 459


>gi|21553331 solute carrier family 2 (facilitated glucose
           transporter), member 12 [Homo sapiens]
          Length = 617

 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 50/216 (23%), Positives = 95/216 (43%), Gaps = 14/216 (6%)

Query: 146 GHGRFQWALFFVLGMALMADGVEVFVVGFVLPSAETDLCIPNSGSGWLGSIVYLGMMVGA 205
           G G F +       ++ +  G E+ ++   L   +T L +       + S + +G ++ +
Sbjct: 35  GCGMFTFLSSVTAAVSGLLVGYELGIISGALLQIKTLLALSCHEQEMVVSSLVIGALLAS 94

Query: 206 FFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLFCRLLSGFGIGGAIPTVFSY 265
              G L D+ GR+ ++++   + G  + +      Y   +  R+  G  I  +      Y
Sbjct: 95  LTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYTVLIVGRIAIGVSISLSSIATCVY 154

Query: 266 FAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWR-VFVI 324
            AE+  + +RG  +S   +  +IG      +  A I +Y +      A  FH W+ +F +
Sbjct: 155 IAEIAPQHRRGLLVSLNELMIVIG------ILSAYISNYAF------ANVFHGWKYMFGL 202

Query: 325 VCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMIL 360
           V  L  V   +A+ F+P SPRFL+  G+   A  +L
Sbjct: 203 VIPLG-VLQAIAMYFLPPSPRFLVMKGQEGAASKVL 237


>gi|24497480 solute carrier family 22 member 6 isoform d [Homo
           sapiens]
          Length = 519

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 67/310 (21%), Positives = 116/310 (37%), Gaps = 48/310 (15%)

Query: 151 QWALFFVLGMALMADGV-EVFVVGFVLPSA--------ETDLCIPNSGSGWLGSIVYL-G 200
           QW L F+ G      G  E    G++  ++        E DL   +     L   +Y+ G
Sbjct: 85  QWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVG 144

Query: 201 MMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLFCRLLSGFGIGGAIP 260
           +++GA  +G LAD++GR++ L++           ++F   +  +   RLLSG  + G   
Sbjct: 145 VLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISL 204

Query: 261 TVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWR 320
              +   E +    R       C+  +IG +Y+           G     G AY    WR
Sbjct: 205 NCMTLNVEWMPIHTRA------CVGTLIGYVYS----------LGQFLLAGVAYAVPHWR 248

Query: 321 VFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQPEKVFTV 380
              ++ + P  +  +   F  ES R+    G+ D     L+ +   N +     +    V
Sbjct: 249 HLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEV 308

Query: 381 NKIKTPKQIDELIEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYPVRDNTIKLTIVW 440
            +    K      E+    G                  +  +RC    +R   + L+++W
Sbjct: 309 LRASLQK------ELTMGKG--------------QASAMELLRC--PTLRHLFLCLSMLW 346

Query: 441 FTLSFGYYGL 450
           F  SF YYGL
Sbjct: 347 FATSFAYYGL 356



 Score = 33.1 bits (74), Expect = 0.94
 Identities = 25/90 (27%), Positives = 43/90 (47%), Gaps = 4/90 (4%)

Query: 582 IYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMI---G 638
           IY +  +     LP  +V  L+++ +GR      +++L+GI C  L     +   I    
Sbjct: 367 IYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGI-CILLNGVIPQDQSIVRTS 425

Query: 639 MLCLYNGLTISAWNSLDVVTVELYPTDRRA 668
           +  L  G   +++N + + T ELYPT  RA
Sbjct: 426 LAVLGKGCLAASFNCIFLYTGELYPTMIRA 455


>gi|24497478 solute carrier family 22 member 6 isoform c [Homo
           sapiens]
          Length = 506

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 67/310 (21%), Positives = 116/310 (37%), Gaps = 48/310 (15%)

Query: 151 QWALFFVLGMALMADGV-EVFVVGFVLPSA--------ETDLCIPNSGSGWLGSIVYL-G 200
           QW L F+ G      G  E    G++  ++        E DL   +     L   +Y+ G
Sbjct: 85  QWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVG 144

Query: 201 MMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLFCRLLSGFGIGGAIP 260
           +++GA  +G LAD++GR++ L++           ++F   +  +   RLLSG  + G   
Sbjct: 145 VLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISL 204

Query: 261 TVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWR 320
              +   E +    R       C+  +IG +Y+           G     G AY    WR
Sbjct: 205 NCMTLNVEWMPIHTRA------CVGTLIGYVYS----------LGQFLLAGVAYAVPHWR 248

Query: 321 VFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQPEKVFTV 380
              ++ + P  +  +   F  ES R+    G+ D     L+ +   N +     +    V
Sbjct: 249 HLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEV 308

Query: 381 NKIKTPKQIDELIEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYPVRDNTIKLTIVW 440
            +    K      E+    G                  +  +RC    +R   + L+++W
Sbjct: 309 LRASLQK------ELTMGKG--------------QASAMELLRC--PTLRHLFLCLSMLW 346

Query: 441 FTLSFGYYGL 450
           F  SF YYGL
Sbjct: 347 FATSFAYYGL 356



 Score = 33.1 bits (74), Expect = 0.94
 Identities = 25/90 (27%), Positives = 43/90 (47%), Gaps = 4/90 (4%)

Query: 582 IYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMI---G 638
           IY +  +     LP  +V  L+++ +GR      +++L+GI C  L     +   I    
Sbjct: 367 IYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGI-CILLNGVIPQDQSIVRTS 425

Query: 639 MLCLYNGLTISAWNSLDVVTVELYPTDRRA 668
           +  L  G   +++N + + T ELYPT  RA
Sbjct: 426 LAVLGKGCLAASFNCIFLYTGELYPTMIRA 455


>gi|24497476 solute carrier family 22 member 6 isoform b [Homo
           sapiens]
          Length = 550

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 67/310 (21%), Positives = 116/310 (37%), Gaps = 48/310 (15%)

Query: 151 QWALFFVLGMALMADGV-EVFVVGFVLPSA--------ETDLCIPNSGSGWLGSIVYL-G 200
           QW L F+ G      G  E    G++  ++        E DL   +     L   +Y+ G
Sbjct: 85  QWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVG 144

Query: 201 MMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLFCRLLSGFGIGGAIP 260
           +++GA  +G LAD++GR++ L++           ++F   +  +   RLLSG  + G   
Sbjct: 145 VLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISL 204

Query: 261 TVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWR 320
              +   E +    R       C+  +IG +Y+           G     G AY    WR
Sbjct: 205 NCMTLNVEWMPIHTRA------CVGTLIGYVYS----------LGQFLLAGVAYAVPHWR 248

Query: 321 VFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQPEKVFTV 380
              ++ + P  +  +   F  ES R+    G+ D     L+ +   N +     +    V
Sbjct: 249 HLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEV 308

Query: 381 NKIKTPKQIDELIEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYPVRDNTIKLTIVW 440
            +    K      E+    G                  +  +RC    +R   + L+++W
Sbjct: 309 LRASLQK------ELTMGKG--------------QASAMELLRC--PTLRHLFLCLSMLW 346

Query: 441 FTLSFGYYGL 450
           F  SF YYGL
Sbjct: 347 FATSFAYYGL 356



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 38/148 (25%), Positives = 69/148 (46%), Gaps = 5/148 (3%)

Query: 582 IYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMI---G 638
           IY +  +     LP  +V  L+++ +GR      +++L+GI C  L     +   I    
Sbjct: 367 IYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGI-CILLNGVIPQDQSIVRTS 425

Query: 639 MLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKS 698
           +  L  G   +++N + + T ELYPT  R TG G  + + +  +++  L+      +  S
Sbjct: 426 LAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLV-SMTAELYPS 484

Query: 699 IPILLASTVLVCGGLVGLCLPDTRTQVL 726
           +P+ +   V V    V + LP+T  Q L
Sbjct: 485 MPLFIYGAVPVAASAVTVLLPETLGQPL 512


>gi|20070188 solute carrier family 22 member 6 isoform a [Homo
           sapiens]
          Length = 563

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 67/310 (21%), Positives = 116/310 (37%), Gaps = 48/310 (15%)

Query: 151 QWALFFVLGMALMADGV-EVFVVGFVLPSA--------ETDLCIPNSGSGWLGSIVYL-G 200
           QW L F+ G      G  E    G++  ++        E DL   +     L   +Y+ G
Sbjct: 85  QWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVG 144

Query: 201 MMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLFCRLLSGFGIGGAIP 260
           +++GA  +G LAD++GR++ L++           ++F   +  +   RLLSG  + G   
Sbjct: 145 VLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISL 204

Query: 261 TVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWR 320
              +   E +    R       C+  +IG +Y+           G     G AY    WR
Sbjct: 205 NCMTLNVEWMPIHTRA------CVGTLIGYVYS----------LGQFLLAGVAYAVPHWR 248

Query: 321 VFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQPEKVFTV 380
              ++ + P  +  +   F  ES R+    G+ D     L+ +   N +     +    V
Sbjct: 249 HLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEV 308

Query: 381 NKIKTPKQIDELIEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYPVRDNTIKLTIVW 440
            +    K      E+    G                  +  +RC    +R   + L+++W
Sbjct: 309 LRASLQK------ELTMGKG--------------QASAMELLRC--PTLRHLFLCLSMLW 346

Query: 441 FTLSFGYYGL 450
           F  SF YYGL
Sbjct: 347 FATSFAYYGL 356



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 38/148 (25%), Positives = 69/148 (46%), Gaps = 5/148 (3%)

Query: 582 IYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMI---G 638
           IY +  +     LP  +V  L+++ +GR      +++L+GI C  L     +   I    
Sbjct: 367 IYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGI-CILLNGVIPQDQSIVRTS 425

Query: 639 MLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKS 698
           +  L  G   +++N + + T ELYPT  R TG G  + + +  +++  L+      +  S
Sbjct: 426 LAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLV-SMTAELYPS 484

Query: 699 IPILLASTVLVCGGLVGLCLPDTRTQVL 726
           +P+ +   V V    V + LP+T  Q L
Sbjct: 485 MPLFIYGAVPVAASAVTVLLPETLGQPL 512


>gi|24497499 solute carrier family 22 member 8 [Homo sapiens]
          Length = 542

 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 58/271 (21%), Positives = 97/271 (35%), Gaps = 40/271 (14%)

Query: 183 LCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYG 242
           +C  N       SI   G+++G    G L+D+ GR+  L     +       ++F   + 
Sbjct: 115 VCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFP 174

Query: 243 FFLFCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIP 302
            ++  R L GFGI G   +      E +    R               I ++A+ +    
Sbjct: 175 IYMVFRFLCGFGISGITLSTVILNVEWVPTRMRA--------------IMSTALGYCYT- 219

Query: 303 HYGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKL 362
            +G     G AY    WR   +  ++P     ++  + PES R+L+  GK  +A  IL+ 
Sbjct: 220 -FGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRR 278

Query: 363 IHDTNMRARGQPEKVFTVNKIKTPKQIDELIEIESDTGTWYRRCFVRIRTELYGIWLTFM 422
           +   N +            K+   K+I                        L     T  
Sbjct: 279 VAVFNGKKEEGERLSLEELKLNLQKEI-----------------------SLAKAKYTAS 315

Query: 423 RCFNYP-VRDNTIKLTIVWFTLSFGYYGLSV 452
             F  P +R  T  L++ WF   F YY L++
Sbjct: 316 DLFRIPMLRRMTFCLSLAWFATGFAYYSLAM 346



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 35/135 (25%), Positives = 64/135 (47%), Gaps = 3/135 (2%)

Query: 594 LPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIG-MLCLYN-GLTISAW 651
           +P   ++ L +  +GR T    +++L+G +   L F   +   +  +L ++  G   S++
Sbjct: 367 VPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKGCLSSSF 426

Query: 652 NSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKSIPILLASTVLVCG 711
           + L + T ELYPT  R TG G  N   +  +++  L+      +   IP ++     + G
Sbjct: 427 SCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLV-KITGEVQPFIPNIIYGITALLG 485

Query: 712 GLVGLCLPDTRTQVL 726
           G   L LP+T  Q L
Sbjct: 486 GSAALFLPETLNQPL 500


>gi|5902090 solute carrier family 2 (facilitated glucose
           transporter), member 3 [Homo sapiens]
          Length = 496

 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 56/209 (26%), Positives = 87/209 (41%), Gaps = 17/209 (8%)

Query: 195 SIVYLGMMVGAFFWGGLADKVGRKQSLLICMSV---NGFFAFLSSFVQGYGFFLFCRLLS 251
           +I  +G M+G+F  G   ++ GR+ S+LI   +    G F  L    +     +  RL+ 
Sbjct: 68  AIFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAVTGGCFMGLCKVAKSVEMLILGRLVI 127

Query: 252 GFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMG 311
           G   G     V  Y  E+     RG     L    ++ GI  + +       +G  F +G
Sbjct: 128 GLFCGLCTGFVPMYIGEISPTALRGA-FGTLNQLGIVVGILVAQI-------FGLEFILG 179

Query: 312 SAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDE-AWMILKLIHDTNMRA 370
           S      W + +    LP +    AL F PESPRFLL   K +E A  IL+ +  T   +
Sbjct: 180 SE---ELWPLLLGFTILPAILQSAALPFCPESPRFLLINRKEEENAKQILQRLWGTQDVS 236

Query: 371 RGQPEKVFTVNKIKTPKQID--ELIEIES 397
           +   E      ++   KQ+   EL  + S
Sbjct: 237 QDIQEMKDESARMSQEKQVTVLELFRVSS 265


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.139    0.437 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,465,040
Number of Sequences: 37866
Number of extensions: 1178132
Number of successful extensions: 6409
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 66
Number of HSP's successfully gapped in prelim test: 135
Number of HSP's that attempted gapping in prelim test: 5578
Number of HSP's gapped (non-prelim): 652
length of query: 727
length of database: 18,247,518
effective HSP length: 110
effective length of query: 617
effective length of database: 14,082,258
effective search space: 8688753186
effective search space used: 8688753186
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.