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Search of human proteins with 72534670
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|72534670 phospholipase A2-activating protein [Homo sapiens]
(795 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|72534670 phospholipase A2-activating protein [Homo sapiens] 1619 0.0
gi|32189425 WD repeat domain 69 [Homo sapiens] 108 1e-23
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 95 3e-19
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 95 3e-19
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 95 3e-19
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 94 5e-19
gi|23199987 WD repeat domain 5B [Homo sapiens] 88 4e-17
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 86 1e-16
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 85 3e-16
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 85 3e-16
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 85 3e-16
gi|19913369 transducin beta-like 3 [Homo sapiens] 84 5e-16
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 83 9e-16
gi|16554629 WD repeat domain 5 [Homo sapiens] 82 1e-15
gi|16554627 WD repeat domain 5 [Homo sapiens] 82 1e-15
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 81 4e-15
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 81 4e-15
gi|113865883 WD repeat domain 38 [Homo sapiens] 81 4e-15
gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)... 79 1e-14
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 78 4e-14
gi|5803221 WD repeat-containing protein 3 [Homo sapiens] 77 8e-14
gi|4759276 RNA, U3 small nucleolar interacting protein 2 [Homo s... 76 1e-13
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 75 3e-13
gi|8923881 WD SOCS-box protein 2 [Homo sapiens] 75 3e-13
gi|5174447 guanine nucleotide binding protein (G protein), beta ... 74 4e-13
gi|21071067 TBP-associated factor 5 [Homo sapiens] 74 5e-13
gi|157266266 WD repeat domain 86 [Homo sapiens] 74 7e-13
gi|26665869 WD repeat domain 51B [Homo sapiens] 72 2e-12
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 72 3e-12
gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens] 71 3e-12
>gi|72534670 phospholipase A2-activating protein [Homo sapiens]
Length = 795
Score = 1619 bits (4193), Expect = 0.0
Identities = 795/795 (100%), Positives = 795/795 (100%)
Query: 1 MTSGATRYRLSCSLRGHELDVRGLVCCAYPPGAFVSVSRDRTTRLWAPDSPNRSFTEMHC 60
MTSGATRYRLSCSLRGHELDVRGLVCCAYPPGAFVSVSRDRTTRLWAPDSPNRSFTEMHC
Sbjct: 1 MTSGATRYRLSCSLRGHELDVRGLVCCAYPPGAFVSVSRDRTTRLWAPDSPNRSFTEMHC 60
Query: 61 MSGHSNFVSCVCIIPSSDIYPHGLIATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLSS 120
MSGHSNFVSCVCIIPSSDIYPHGLIATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLSS
Sbjct: 61 MSGHSNFVSCVCIIPSSDIYPHGLIATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLSS 120
Query: 121 GKFGTLLSGSWDTTAKVWLNDKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLWKA 180
GKFGTLLSGSWDTTAKVWLNDKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLWKA
Sbjct: 121 GKFGTLLSGSWDTTAKVWLNDKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLWKA 180
Query: 181 GRCERTFSGHEDCVRGLAILSETEFLSCANDASIRRWQITGECLEVYYGHTNYIYSISVF 240
GRCERTFSGHEDCVRGLAILSETEFLSCANDASIRRWQITGECLEVYYGHTNYIYSISVF
Sbjct: 181 GRCERTFSGHEDCVRGLAILSETEFLSCANDASIRRWQITGECLEVYYGHTNYIYSISVF 240
Query: 241 PNCRDFVTTAEDRSLRIWKHGECAQTIRLPAQSIWCCCVLDNGDIVVGASDGIIRVFTES 300
PNCRDFVTTAEDRSLRIWKHGECAQTIRLPAQSIWCCCVLDNGDIVVGASDGIIRVFTES
Sbjct: 241 PNCRDFVTTAEDRSLRIWKHGECAQTIRLPAQSIWCCCVLDNGDIVVGASDGIIRVFTES 300
Query: 301 EDRTASAEEIKAFEKELSHATIDSKTGDLGDINAEQLPGREHLNEPGTREGQTRLIRDGE 360
EDRTASAEEIKAFEKELSHATIDSKTGDLGDINAEQLPGREHLNEPGTREGQTRLIRDGE
Sbjct: 301 EDRTASAEEIKAFEKELSHATIDSKTGDLGDINAEQLPGREHLNEPGTREGQTRLIRDGE 360
Query: 361 KVEAYQWSVSEGRWIKIGDVVGSSGANQQTSGKVLYEGKEFDYVFSIDVNEGGPSYKLPY 420
KVEAYQWSVSEGRWIKIGDVVGSSGANQQTSGKVLYEGKEFDYVFSIDVNEGGPSYKLPY
Sbjct: 361 KVEAYQWSVSEGRWIKIGDVVGSSGANQQTSGKVLYEGKEFDYVFSIDVNEGGPSYKLPY 420
Query: 421 NTSDDPWLTAYNFLQKNDLNPMFLDQVAKFIIDNTKGQMLGLGNPSFSDPFTGGGRYVPG 480
NTSDDPWLTAYNFLQKNDLNPMFLDQVAKFIIDNTKGQMLGLGNPSFSDPFTGGGRYVPG
Sbjct: 421 NTSDDPWLTAYNFLQKNDLNPMFLDQVAKFIIDNTKGQMLGLGNPSFSDPFTGGGRYVPG 480
Query: 481 SSGSSNTLPTADPFTGAGRYVPGSASMGTTMAGVDPFTGNSAYRSAASKTMNIYFPKKEA 540
SSGSSNTLPTADPFTGAGRYVPGSASMGTTMAGVDPFTGNSAYRSAASKTMNIYFPKKEA
Sbjct: 481 SSGSSNTLPTADPFTGAGRYVPGSASMGTTMAGVDPFTGNSAYRSAASKTMNIYFPKKEA 540
Query: 541 VTFDQANPTQILGKLKELNGTAPEEKKLTEDDLILLEKILSLICNSSSEKPTVQQLQILW 600
VTFDQANPTQILGKLKELNGTAPEEKKLTEDDLILLEKILSLICNSSSEKPTVQQLQILW
Sbjct: 541 VTFDQANPTQILGKLKELNGTAPEEKKLTEDDLILLEKILSLICNSSSEKPTVQQLQILW 600
Query: 601 KAINCPEDIVFPALDILRLSIKHPSVNENFCNEKEGAQFSSHLINLLNPKGKPANQLLAL 660
KAINCPEDIVFPALDILRLSIKHPSVNENFCNEKEGAQFSSHLINLLNPKGKPANQLLAL
Sbjct: 601 KAINCPEDIVFPALDILRLSIKHPSVNENFCNEKEGAQFSSHLINLLNPKGKPANQLLAL 660
Query: 661 RTFCNCFVGQAGQKLMMSQRESLMSHAIELKSGSNKNIHIALATLALNYSVCFHKDHNIE 720
RTFCNCFVGQAGQKLMMSQRESLMSHAIELKSGSNKNIHIALATLALNYSVCFHKDHNIE
Sbjct: 661 RTFCNCFVGQAGQKLMMSQRESLMSHAIELKSGSNKNIHIALATLALNYSVCFHKDHNIE 720
Query: 721 GKAQCLSLISTILEVVQDLEATFRLLVALGTLISDDSNAVQLAKSLGVDSQIKKYSSVSE 780
GKAQCLSLISTILEVVQDLEATFRLLVALGTLISDDSNAVQLAKSLGVDSQIKKYSSVSE
Sbjct: 721 GKAQCLSLISTILEVVQDLEATFRLLVALGTLISDDSNAVQLAKSLGVDSQIKKYSSVSE 780
Query: 781 PAKVSECCRFILNLL 795
PAKVSECCRFILNLL
Sbjct: 781 PAKVSECCRFILNLL 795
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 108 bits (271), Expect = 1e-23
Identities = 80/270 (29%), Positives = 131/270 (48%), Gaps = 19/270 (7%)
Query: 38 SRDRTTRLWAPDSPNRSFTEMHCMSGHSNFVSCVCIIPSSDIYPHGLIATGGNDHNICIF 97
S D+T +LW+ ++ H GH+ + C+ P S L+ATG D ++
Sbjct: 154 SFDKTCKLWSVETGKC----YHTFRGHTAEIVCLSFNPQST-----LVATGSMDTTAKLW 204
Query: 98 SLDSPMPLYILKGHKNTVCSLSSGKFGT-LLSGSWDTTAKVWLND--KCMMTLQGHTAAV 154
+ + +Y L+GH + SLS G +++GS+D T VW D + + L GH A +
Sbjct: 205 DIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEI 264
Query: 155 WAVKILPEQGLMLTGSADKTVKLWKA--GRCERTFSGHEDCVRGLAILSETEFLSCAN-D 211
+ + L+LTGS DKT KLW A G+C T +GH+D + + ++ A+ D
Sbjct: 265 SSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASAD 324
Query: 212 ASIRRWQI-TGECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIW--KHGECAQTIR 268
+ R + T +C+ GH I IS P +T + D++ RIW + G+C Q +
Sbjct: 325 GTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLE 384
Query: 269 LPAQSIWCCCVLDNGDIVV-GASDGIIRVF 297
I+ C G+IV+ G+ D R++
Sbjct: 385 GHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 96.3 bits (238), Expect = 1e-19
Identities = 75/256 (29%), Positives = 123/256 (48%), Gaps = 21/256 (8%)
Query: 13 SLRGHELDVRGLVCCAYPPGAFVSV--SRDRTTRLWAPDSPNRSFTEMHCMSGHSNFVSC 70
+ RGH ++ VC ++ P + + S D T +LW D N E++ + GHS +
Sbjct: 172 TFRGHTAEI---VCLSFNPQSTLVATGSMDTTAKLW--DIQNGE--EVYTLRGHSAEIIS 224
Query: 71 VCIIPSSDIYPHGLIATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLS-SGKFGTLLSG 129
+ S D I TG DH + ++ D+ + IL GH + S S + +L+G
Sbjct: 225 LSFNTSGD-----RIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTG 279
Query: 130 SWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLWKAG--RCER 185
S D T K+W N KC+ TL GH + L+ T SAD T +++ A +C
Sbjct: 280 SMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIA 339
Query: 186 TFSGHEDCVRGLAILSE-TEFLSCANDASIRRWQI-TGECLEVYYGHTNYIYSISVFPNC 243
GHE + ++ + L+ ++D + R W TG+CL+V GHT+ I+S +
Sbjct: 340 KLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKG 399
Query: 244 RDFVTTAEDRSLRIWK 259
+T ++D + RIW+
Sbjct: 400 NIVITGSKDNTCRIWR 415
Score = 87.0 bits (214), Expect = 6e-17
Identities = 69/254 (27%), Positives = 121/254 (47%), Gaps = 13/254 (5%)
Query: 87 TGGNDHNICIFSLDSPMPLYILKGHKNTVCSLS-SGKFGT-LLSGSWDTTAKVWLND--K 142
TG D ++ S L L+GH+N V +++ + +G + +GS+D T K+W + K
Sbjct: 109 TGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGK 168
Query: 143 CMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLWKAGRCER--TFSGHEDCVRGLAI- 199
C T +GHTA + + P+ L+ TGS D T KLW E T GH + L+
Sbjct: 169 CYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFN 228
Query: 200 LSETEFLSCANDASIRRWQI-TGECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIW 258
S ++ + D ++ W TG + + GH I S S +C +T + D++ ++W
Sbjct: 229 TSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLW 288
Query: 259 --KHGECAQTIRLPAQSIWCCCVLDNGDIVVGAS-DGIIRVFTESEDRTASAEEIKAFEK 315
+G+C T+ I C G ++ AS DG R+F+ + + + +++ E
Sbjct: 289 DATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIA--KLEGHEG 346
Query: 316 ELSHATIDSKTGDL 329
E+S + + + L
Sbjct: 347 EISKISFNPQGNHL 360
Score = 54.7 bits (130), Expect = 3e-07
Identities = 43/165 (26%), Positives = 73/165 (44%), Gaps = 8/165 (4%)
Query: 147 LQGHTAAVWAVKILPEQGLMLTGSADKTVKLWKAGRCE--RTFSGHEDCVRGLAILSE-- 202
L+ H + V + +TGS D+T KLW E T GH + V +A +
Sbjct: 88 LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYG 147
Query: 203 TEFLSCANDASIRRWQI-TGECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIW--K 259
+ + + D + + W + TG+C + GHT I +S P T + D + ++W +
Sbjct: 148 DKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQ 207
Query: 260 HGECAQTIRLPAQSIWCCCVLDNGD-IVVGASDGIIRVFTESEDR 303
+GE T+R + I +GD I+ G+ D + V+ R
Sbjct: 208 NGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGR 252
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 94.7 bits (234), Expect = 3e-19
Identities = 65/198 (32%), Positives = 103/198 (52%), Gaps = 13/198 (6%)
Query: 107 ILKGHKNTVCSLSSGKFGTLLSGSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQG 164
+LKGH + V + ++SGS D T KVW + KC+ TL GHT VW+ ++
Sbjct: 257 VLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM--RDN 314
Query: 165 LMLTGSADKTVKLWKA--GRCERTFSGHEDCVRGLAILSETEFLSCANDASIRRWQI-TG 221
++++GS D+T+K+W A G C T GH VR + L E +S + DA++R W I TG
Sbjct: 315 IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMH-LHEKRVVSGSRDATLRVWDIETG 373
Query: 222 ECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIW--KHGECAQTIRLPAQSIWCCCV 279
+CL V GH + + + R V+ A D +++W + C T++ ++
Sbjct: 374 QCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY-SLQ 430
Query: 280 LDNGDIVVGASDGIIRVF 297
D +V G+ D IRV+
Sbjct: 431 FDGIHVVSGSLDTSIRVW 448
Score = 92.4 bits (228), Expect = 1e-18
Identities = 63/238 (26%), Positives = 128/238 (53%), Gaps = 27/238 (11%)
Query: 35 VSVSRDRTTRLWAPDSPNRSFTEMHCMSGHSNFVSCVCIIPSSDIYPHGLIATGGNDHNI 94
+S S DRT ++W ++ +H + GH++ V C+ + + +G D +
Sbjct: 317 ISGSTDRTLKVWNAETGEC----IHTLYGHTSTVRCMHLHEKR-------VVSGSRDATL 365
Query: 95 CIFSLDSPMPLYILKGHKNTV-CSLSSGKFGTLLSGSWDTTAKVW--LNDKCMMTLQGHT 151
++ +++ L++L GH V C G+ ++SG++D KVW + C+ TLQGHT
Sbjct: 366 RVWDIETGQCLHVLMGHVAAVRCVQYDGR--RVVSGAYDFMVKVWDPETETCLHTLQGHT 423
Query: 152 AAVWAVKILPEQGL-MLTGSADKTVKLW--KAGRCERTFSGHEDCVRGLAILSETEFLSC 208
V++++ G+ +++GS D ++++W + G C T +GH+ G+ L + +S
Sbjct: 424 NRVYSLQF---DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGME-LKDNILVSG 479
Query: 209 ANDASIRRWQI-TGECLEVYYGHTNYIYSISVFPNCRDFV-TTAEDRSLRIW--KHGE 262
D++++ W I TG+CL+ G + +++ ++FV T+++D ++++W K GE
Sbjct: 480 NADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGE 537
Score = 78.6 bits (192), Expect = 2e-14
Identities = 63/218 (28%), Positives = 107/218 (49%), Gaps = 26/218 (11%)
Query: 13 SLRGHELDVRGLVCCAYPPGAFVSVSRDRTTRLWAPDSPNRSFTEMHCMSGHSNFVSCVC 72
+L GH VR C VS SRD T R+W ++ +H + GH V CV
Sbjct: 338 TLYGHTSTVR---CMHLHEKRVVSGSRDATLRVWDIETGQC----LHVLMGHVAAVRCVQ 390
Query: 73 IIPSSDIYPHGLIATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLSSGKFGTLLSGSWD 132
Y + +G D + ++ ++ L+ L+GH N V SL ++SGS D
Sbjct: 391 -------YDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIH-VVSGSLD 442
Query: 133 TTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLW--KAGRCERTFS 188
T+ +VW C+ TL GH + +++ + ++++G+AD TVK+W K G+C +T
Sbjct: 443 TSIRVWDVETGNCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQCLQTLQ 500
Query: 189 G---HEDCVRGLAILSETEFLSCANDASIRRWQI-TGE 222
G H+ V L ++ ++ ++D +++ W + TGE
Sbjct: 501 GPNKHQSAVTCLQ-FNKNFVITSSDDGTVKLWDLKTGE 537
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 94.7 bits (234), Expect = 3e-19
Identities = 65/198 (32%), Positives = 103/198 (52%), Gaps = 13/198 (6%)
Query: 107 ILKGHKNTVCSLSSGKFGTLLSGSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQG 164
+LKGH + V + ++SGS D T KVW + KC+ TL GHT VW+ ++
Sbjct: 375 VLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM--RDN 432
Query: 165 LMLTGSADKTVKLWKA--GRCERTFSGHEDCVRGLAILSETEFLSCANDASIRRWQI-TG 221
++++GS D+T+K+W A G C T GH VR + L E +S + DA++R W I TG
Sbjct: 433 IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMH-LHEKRVVSGSRDATLRVWDIETG 491
Query: 222 ECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIW--KHGECAQTIRLPAQSIWCCCV 279
+CL V GH + + + R V+ A D +++W + C T++ ++
Sbjct: 492 QCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY-SLQ 548
Query: 280 LDNGDIVVGASDGIIRVF 297
D +V G+ D IRV+
Sbjct: 549 FDGIHVVSGSLDTSIRVW 566
Score = 92.4 bits (228), Expect = 1e-18
Identities = 63/238 (26%), Positives = 128/238 (53%), Gaps = 27/238 (11%)
Query: 35 VSVSRDRTTRLWAPDSPNRSFTEMHCMSGHSNFVSCVCIIPSSDIYPHGLIATGGNDHNI 94
+S S DRT ++W ++ +H + GH++ V C+ + + +G D +
Sbjct: 435 ISGSTDRTLKVWNAETGEC----IHTLYGHTSTVRCMHLHEKR-------VVSGSRDATL 483
Query: 95 CIFSLDSPMPLYILKGHKNTV-CSLSSGKFGTLLSGSWDTTAKVW--LNDKCMMTLQGHT 151
++ +++ L++L GH V C G+ ++SG++D KVW + C+ TLQGHT
Sbjct: 484 RVWDIETGQCLHVLMGHVAAVRCVQYDGR--RVVSGAYDFMVKVWDPETETCLHTLQGHT 541
Query: 152 AAVWAVKILPEQGL-MLTGSADKTVKLW--KAGRCERTFSGHEDCVRGLAILSETEFLSC 208
V++++ G+ +++GS D ++++W + G C T +GH+ G+ L + +S
Sbjct: 542 NRVYSLQF---DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGME-LKDNILVSG 597
Query: 209 ANDASIRRWQI-TGECLEVYYGHTNYIYSISVFPNCRDFV-TTAEDRSLRIW--KHGE 262
D++++ W I TG+CL+ G + +++ ++FV T+++D ++++W K GE
Sbjct: 598 NADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGE 655
Score = 78.6 bits (192), Expect = 2e-14
Identities = 63/218 (28%), Positives = 107/218 (49%), Gaps = 26/218 (11%)
Query: 13 SLRGHELDVRGLVCCAYPPGAFVSVSRDRTTRLWAPDSPNRSFTEMHCMSGHSNFVSCVC 72
+L GH VR C VS SRD T R+W ++ +H + GH V CV
Sbjct: 456 TLYGHTSTVR---CMHLHEKRVVSGSRDATLRVWDIETGQC----LHVLMGHVAAVRCVQ 508
Query: 73 IIPSSDIYPHGLIATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLSSGKFGTLLSGSWD 132
Y + +G D + ++ ++ L+ L+GH N V SL ++SGS D
Sbjct: 509 -------YDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIH-VVSGSLD 560
Query: 133 TTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLW--KAGRCERTFS 188
T+ +VW C+ TL GH + +++ + ++++G+AD TVK+W K G+C +T
Sbjct: 561 TSIRVWDVETGNCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQCLQTLQ 618
Query: 189 G---HEDCVRGLAILSETEFLSCANDASIRRWQI-TGE 222
G H+ V L ++ ++ ++D +++ W + TGE
Sbjct: 619 GPNKHQSAVTCLQ-FNKNFVITSSDDGTVKLWDLKTGE 655
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 94.7 bits (234), Expect = 3e-19
Identities = 65/198 (32%), Positives = 103/198 (52%), Gaps = 13/198 (6%)
Query: 107 ILKGHKNTVCSLSSGKFGTLLSGSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQG 164
+LKGH + V + ++SGS D T KVW + KC+ TL GHT VW+ ++
Sbjct: 295 VLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM--RDN 352
Query: 165 LMLTGSADKTVKLWKA--GRCERTFSGHEDCVRGLAILSETEFLSCANDASIRRWQI-TG 221
++++GS D+T+K+W A G C T GH VR + L E +S + DA++R W I TG
Sbjct: 353 IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMH-LHEKRVVSGSRDATLRVWDIETG 411
Query: 222 ECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIW--KHGECAQTIRLPAQSIWCCCV 279
+CL V GH + + + R V+ A D +++W + C T++ ++
Sbjct: 412 QCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY-SLQ 468
Query: 280 LDNGDIVVGASDGIIRVF 297
D +V G+ D IRV+
Sbjct: 469 FDGIHVVSGSLDTSIRVW 486
Score = 92.4 bits (228), Expect = 1e-18
Identities = 63/238 (26%), Positives = 128/238 (53%), Gaps = 27/238 (11%)
Query: 35 VSVSRDRTTRLWAPDSPNRSFTEMHCMSGHSNFVSCVCIIPSSDIYPHGLIATGGNDHNI 94
+S S DRT ++W ++ +H + GH++ V C+ + + +G D +
Sbjct: 355 ISGSTDRTLKVWNAETGEC----IHTLYGHTSTVRCMHLHEKR-------VVSGSRDATL 403
Query: 95 CIFSLDSPMPLYILKGHKNTV-CSLSSGKFGTLLSGSWDTTAKVW--LNDKCMMTLQGHT 151
++ +++ L++L GH V C G+ ++SG++D KVW + C+ TLQGHT
Sbjct: 404 RVWDIETGQCLHVLMGHVAAVRCVQYDGR--RVVSGAYDFMVKVWDPETETCLHTLQGHT 461
Query: 152 AAVWAVKILPEQGL-MLTGSADKTVKLW--KAGRCERTFSGHEDCVRGLAILSETEFLSC 208
V++++ G+ +++GS D ++++W + G C T +GH+ G+ L + +S
Sbjct: 462 NRVYSLQF---DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGME-LKDNILVSG 517
Query: 209 ANDASIRRWQI-TGECLEVYYGHTNYIYSISVFPNCRDFV-TTAEDRSLRIW--KHGE 262
D++++ W I TG+CL+ G + +++ ++FV T+++D ++++W K GE
Sbjct: 518 NADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGE 575
Score = 78.6 bits (192), Expect = 2e-14
Identities = 63/218 (28%), Positives = 107/218 (49%), Gaps = 26/218 (11%)
Query: 13 SLRGHELDVRGLVCCAYPPGAFVSVSRDRTTRLWAPDSPNRSFTEMHCMSGHSNFVSCVC 72
+L GH VR C VS SRD T R+W ++ +H + GH V CV
Sbjct: 376 TLYGHTSTVR---CMHLHEKRVVSGSRDATLRVWDIETGQC----LHVLMGHVAAVRCVQ 428
Query: 73 IIPSSDIYPHGLIATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLSSGKFGTLLSGSWD 132
Y + +G D + ++ ++ L+ L+GH N V SL ++SGS D
Sbjct: 429 -------YDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIH-VVSGSLD 480
Query: 133 TTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLW--KAGRCERTFS 188
T+ +VW C+ TL GH + +++ + ++++G+AD TVK+W K G+C +T
Sbjct: 481 TSIRVWDVETGNCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQCLQTLQ 538
Query: 189 G---HEDCVRGLAILSETEFLSCANDASIRRWQI-TGE 222
G H+ V L ++ ++ ++D +++ W + TGE
Sbjct: 539 GPNKHQSAVTCLQ-FNKNFVITSSDDGTVKLWDLKTGE 575
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 94.0 bits (232), Expect = 5e-19
Identities = 72/274 (26%), Positives = 124/274 (45%), Gaps = 37/274 (13%)
Query: 13 SLRGHELDVRGLVCCAYPPGAFVSVSRDRTTRLWAPDSPNRSFTEMHCMSGHSNFVSCVC 72
+L+GH V+ + + S S D T +LW + F + M GH + VS V
Sbjct: 145 TLKGHTDSVQD-ISFDHSGKLLASCSADMTIKLW----DFQGFECIRTMHGHDHNVSSVA 199
Query: 73 IIPSSDIYPHGLIATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLSSGKFGTLLSG-SW 131
I+P+ D I + D I ++ + + + GH+ V + + GTL++ S
Sbjct: 200 IMPNGDH-----IVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSN 254
Query: 132 DTTAKVWL--NDKCMMTLQGHTAAVWAVKILPEQG--------------------LMLTG 169
D T +VW+ +C L+ H V + PE +L+G
Sbjct: 255 DQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSG 314
Query: 170 SADKTVKLW--KAGRCERTFSGHEDCVRGLAILSETEF-LSCANDASIRRWQITGE-CLE 225
S DKT+K+W G C T GH++ VRG+ S +F LSCA+D ++R W + C++
Sbjct: 315 SRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMK 374
Query: 226 VYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIWK 259
H +++ S+ VT + D+++++W+
Sbjct: 375 TLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
Score = 85.5 bits (210), Expect = 2e-16
Identities = 63/212 (29%), Positives = 104/212 (49%), Gaps = 17/212 (8%)
Query: 37 VSRDRTTRLWAPDSPNRSFTEMHCMSGHSNFVSCVCIIPSSDIYPHGLIATGGNDHNICI 96
+ + R + W P P E + +SGH + V+ V P + + + D I +
Sbjct: 85 LGQKRDPKEWIPRPP-----EKYALSGHRSPVTRVIFHPVFSV-----MVSASEDATIKV 134
Query: 97 FSLDSPMPLYILKGHKNTVCSLSSGKFGTLLSG-SWDTTAKVW--LNDKCMMTLQGHTAA 153
+ ++ LKGH ++V +S G LL+ S D T K+W +C+ T+ GH
Sbjct: 135 WDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHN 194
Query: 154 VWAVKILPEQGLMLTGSADKTVKLW--KAGRCERTFSGHEDCVRGLAILSE-TEFLSCAN 210
V +V I+P +++ S DKT+K+W + G C +TF+GH + VR + + T SC+N
Sbjct: 195 VSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSN 254
Query: 211 DASIRRWQI-TGECLEVYYGHTNYIYSISVFP 241
D ++R W + T EC H + + IS P
Sbjct: 255 DQTVRVWVVATKECKAELREHEHVVECISWAP 286
Score = 78.2 bits (191), Expect = 3e-14
Identities = 53/182 (29%), Positives = 90/182 (49%), Gaps = 17/182 (9%)
Query: 147 LQGHTAAVWAVKILPEQGLMLTGSADKTVKLW--KAGRCERTFSGHEDCVRGLAILSETE 204
L GH + V V P +M++ S D T+K+W + G ERT GH D V+ ++ +
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGK 163
Query: 205 FL-SCANDASIRRWQITG-ECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIW--KH 260
L SC+ D +I+ W G EC+ +GH + + S+++ PN V+ + D+++++W +
Sbjct: 164 LLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQT 223
Query: 261 GECAQTIRLPAQSIWCCCVLDNGD---IVVGASDGIIRVFTESEDRTASAEEIKAFEKEL 317
G C +T W V N D I ++D +RV+ + +E KA +E
Sbjct: 224 GYCVKT--FTGHREWVRMVRPNQDGTLIASCSNDQTVRVW------VVATKECKAELREH 275
Query: 318 SH 319
H
Sbjct: 276 EH 277
Score = 72.0 bits (175), Expect = 2e-12
Identities = 68/286 (23%), Positives = 123/286 (43%), Gaps = 43/286 (15%)
Query: 13 SLRGHELDVRGLVCCAYPP--GAFVSVSRDRTTRLWAPDSPNRSFTEMHCMSGHSNFVSC 70
+L GH V ++ + P VS S D T ++W ++ + T + GH++ V
Sbjct: 103 ALSGHRSPVTRVI---FHPVFSVMVSASEDATIKVWDYETGDFERT----LKGHTDSVQD 155
Query: 71 VCIIPSSDIYPHGLIATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLSSGKFGT-LLSG 129
+ S L+A+ D I ++ + + GH + V S++ G ++S
Sbjct: 156 ISFDHSGK-----LLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSA 210
Query: 130 SWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLWKAG--RCER 185
S D T K+W C+ T GH V V+ + L+ + S D+TV++W C+
Sbjct: 211 SRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKA 270
Query: 186 TFSGHEDCVRGLAILSETEF---------------------LSCANDASIRRWQI-TGEC 223
HE V ++ E+ + LS + D +I+ W + TG C
Sbjct: 271 ELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMC 330
Query: 224 LEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIW--KHGECAQTI 267
L GH N++ + + ++ A+D++LR+W K+ C +T+
Sbjct: 331 LMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTL 376
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 87.8 bits (216), Expect = 4e-17
Identities = 75/265 (28%), Positives = 123/265 (46%), Gaps = 23/265 (8%)
Query: 48 PDSPNRSFTEMHC-MSGHSNFVSCVCIIPSSDIYPHGLIATGGNDHNICIFSLDSPMPLY 106
P++PN + + C + GH+ VS V P+ + +A+ D I I+
Sbjct: 26 PENPNYA---LKCTLVGHTEAVSSVKFSPNGE-----WLASSSADRLIIIWGAYDGKYEK 77
Query: 107 ILKGHKNTVCSLS-SGKFGTLLSGSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQ 163
L GH + ++ S L+S S D T K+W + KC+ TL+GH+ V+ P
Sbjct: 78 TLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPS 137
Query: 164 GLMLTGSADKTVKLW--KAGRCERTFSGHEDCVRGLAI-LSETEFLSCANDASIRRWQ-I 219
L+++GS D+TVK+W K G+C +T S H D V + S + +S + D R W
Sbjct: 138 NLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAA 197
Query: 220 TGECLEVYYGHTNYIYSISVF-PNCRDFVTTAEDRSLRIWKH--GECAQTIRLPAQSIWC 276
+G+CL+ N S F PN + +T D +L++W + G C +T +C
Sbjct: 198 SGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYC 257
Query: 277 C----CVLDNGDIVVGASDGIIRVF 297
V IV G+ D ++ ++
Sbjct: 258 IFANFSVTGGKWIVSGSEDNLVYIW 282
Score = 33.9 bits (76), Expect = 0.61
Identities = 27/119 (22%), Positives = 55/119 (46%), Gaps = 16/119 (13%)
Query: 30 PPGAFV-SVSRDRTTRLWAPDSPNRSFTEMHCM---SGHSNFVSCVCIIPSSDIYPHGLI 85
P G ++ + + D T +LW ++ C+ +GH N CI + + I
Sbjct: 220 PNGKYILTATLDNTLKLW-------DYSRGRCLKTYTGHKN--EKYCIFANFSVTGGKWI 270
Query: 86 ATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLSSGKFGTLLSGSW---DTTAKVWLND 141
+G D+ + I++L + + L+GH + V S + L++ + D T K+W+++
Sbjct: 271 VSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLWMSN 329
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 86.3 bits (212), Expect = 1e-16
Identities = 66/217 (30%), Positives = 99/217 (45%), Gaps = 12/217 (5%)
Query: 49 DSPNRSFTEMHCMSGHSNFVSCVCIIPSSDIYPHGLIATGGNDHNICIFSLDSPMPLYIL 108
D + + TEM + GH V + S GL++ D +I + L S +
Sbjct: 326 DEDDNAGTEMKILRGHCGPVYSTRFLADSS----GLLSCS-EDMSIRYWDLGSFTNTVLY 380
Query: 109 KGHKNTVCSLSSGKFGTLL-SGSWDTTAKVWLNDKC--MMTLQGHTAAVWAVKILPEQGL 165
+GH V L + SGS D TA++W D+ + GH A V VK P
Sbjct: 381 QGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNY 440
Query: 166 MLTGSADKTVKLWKA--GRCERTFSGHEDCVRGLAILSETEFL-SCANDASIRRWQI-TG 221
+ TGS DKTV+LW A G R F+GH V LA ++L S D ++ W + +G
Sbjct: 441 LATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASG 500
Query: 222 ECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIW 258
+ GHT+ I S++ P+ + + D S+R+W
Sbjct: 501 TLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVW 537
Score = 65.5 bits (158), Expect = 2e-10
Identities = 46/150 (30%), Positives = 75/150 (50%), Gaps = 16/150 (10%)
Query: 34 FVSVSRDRTTRLWAPDSPNRSFTEMHCMSGHSNFVSCVCIIPSSDIYPHGLIATGGNDHN 93
F S S DRT RLW+ D R++ + +GH V CV P+S+ +ATG D
Sbjct: 399 FASGSHDRTARLWSFD---RTY-PLRIYAGHLADVDCVKFHPNSN-----YLATGSTDKT 449
Query: 94 ICIFSLDSPMPLYILKGHKNTVCSLS---SGKFGTLLSGSWDTTAKVW--LNDKCMMTLQ 148
+ ++S + + GH+ V SL+ +GK+ L S D K+W + L+
Sbjct: 450 VRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKY--LASAGEDQRLKLWDLASGTLYKELR 507
Query: 149 GHTAAVWAVKILPEQGLMLTGSADKTVKLW 178
GHT + ++ P+ GL+ + S D +V++W
Sbjct: 508 GHTDNITSLTFSPDSGLIASASMDNSVRVW 537
Score = 32.0 bits (71), Expect = 2.3
Identities = 23/110 (20%), Positives = 44/110 (40%), Gaps = 6/110 (5%)
Query: 158 KILPEQGLMLTGSADKTVKLWKAGRCERTFSGHEDCVRGLAILSETEFLSCANDASIRRW 217
+I P+ L+ G + +KLW + H+ V + + + L +D
Sbjct: 275 EISPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACD--ILEEEDDEDDN-- 330
Query: 218 QITGECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIWKHGECAQTI 267
G +++ GH +YS + ++ +ED S+R W G T+
Sbjct: 331 --AGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTV 378
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 84.7 bits (208), Expect = 3e-16
Identities = 80/295 (27%), Positives = 132/295 (44%), Gaps = 34/295 (11%)
Query: 22 RGLVCCAYPPGAFVSVSRDRTTRLWAPDSPNRSFTEMHCMSGHSNFVSCVCIIPSSDIYP 81
+G+ C Y +S RD + ++W S + ++GH+ V C+ Y
Sbjct: 241 KGVYCLQYDDEKIISGLRDNSIKIW----DKTSLECLKVLTGHTGSVLCLQ-------YD 289
Query: 82 HGLIATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLSSGKFGTLLSGSWDTTAKVWLND 141
+I TG +D + ++ +++ L L H V L G +++ S D + VW D
Sbjct: 290 ERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSN-GLMVTCSKDRSIAVW--D 346
Query: 142 KCMMT-------LQGHTAAVWAVKILPEQGLMLTGSADKTVKLWKAGRCE--RTFSGHED 192
T L GH AAV V + +++ S D+T+K+W CE RT +GH+
Sbjct: 347 MASATDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHK- 403
Query: 193 CVRGLAILSETEFL--SCANDASIRRWQI-TGECLEVYYGHTNYIYSISVFPNCRDFVTT 249
RG+A L + L S ++D +IR W I G CL V GH + I F N R V+
Sbjct: 404 --RGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIR-FDNKR-IVSG 459
Query: 250 AEDRSLRIWKHGECAQTIRLPAQSIWCCCVLDNGDIVVGASDGIIRVFTESEDRT 304
A D +++W + A R PA ++ ++++ V ++ + S D T
Sbjct: 460 AYDGKIKVWDL-QAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDT 513
Score = 38.5 bits (88), Expect = 0.025
Identities = 36/135 (26%), Positives = 53/135 (39%), Gaps = 24/135 (17%)
Query: 13 SLRGHELDVRGLVCCAYPPGAFVSVSRDRTTRLWAPDSPNRSFTEMHCMSGHSNFVSCVC 72
+L GH+ RG+ C Y VS S D T RLW + + + GH V C+
Sbjct: 398 TLNGHK---RGIACLQYRDRLVVSGSSDNTIRLWDIECG----ACLRVLEGHEELVRCI- 449
Query: 73 IIPSSDIYPHGLIATGGNDHNICIFSLD---------SPMPLYILKGHKNTVCSLSSGKF 123
+ + I +G D I ++ L S + L L H V L +F
Sbjct: 450 ------RFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEF 503
Query: 124 GTLLSGSWDTTAKVW 138
++S S D T +W
Sbjct: 504 -QIISSSHDDTILIW 517
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 84.7 bits (208), Expect = 3e-16
Identities = 80/295 (27%), Positives = 132/295 (44%), Gaps = 34/295 (11%)
Query: 22 RGLVCCAYPPGAFVSVSRDRTTRLWAPDSPNRSFTEMHCMSGHSNFVSCVCIIPSSDIYP 81
+G+ C Y +S RD + ++W S + ++GH+ V C+ Y
Sbjct: 207 KGVYCLQYDDEKIISGLRDNSIKIW----DKTSLECLKVLTGHTGSVLCLQ-------YD 255
Query: 82 HGLIATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLSSGKFGTLLSGSWDTTAKVWLND 141
+I TG +D + ++ +++ L L H V L G +++ S D + VW D
Sbjct: 256 ERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSN-GLMVTCSKDRSIAVW--D 312
Query: 142 KCMMT-------LQGHTAAVWAVKILPEQGLMLTGSADKTVKLWKAGRCE--RTFSGHED 192
T L GH AAV V + +++ S D+T+K+W CE RT +GH+
Sbjct: 313 MASATDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHK- 369
Query: 193 CVRGLAILSETEFL--SCANDASIRRWQI-TGECLEVYYGHTNYIYSISVFPNCRDFVTT 249
RG+A L + L S ++D +IR W I G CL V GH + I F N R V+
Sbjct: 370 --RGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIR-FDNKR-IVSG 425
Query: 250 AEDRSLRIWKHGECAQTIRLPAQSIWCCCVLDNGDIVVGASDGIIRVFTESEDRT 304
A D +++W + A R PA ++ ++++ V ++ + S D T
Sbjct: 426 AYDGKIKVWDL-QAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDT 479
Score = 38.5 bits (88), Expect = 0.025
Identities = 36/135 (26%), Positives = 53/135 (39%), Gaps = 24/135 (17%)
Query: 13 SLRGHELDVRGLVCCAYPPGAFVSVSRDRTTRLWAPDSPNRSFTEMHCMSGHSNFVSCVC 72
+L GH+ RG+ C Y VS S D T RLW + + + GH V C+
Sbjct: 364 TLNGHK---RGIACLQYRDRLVVSGSSDNTIRLWDIECG----ACLRVLEGHEELVRCI- 415
Query: 73 IIPSSDIYPHGLIATGGNDHNICIFSLD---------SPMPLYILKGHKNTVCSLSSGKF 123
+ + I +G D I ++ L S + L L H V L +F
Sbjct: 416 ------RFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEF 469
Query: 124 GTLLSGSWDTTAKVW 138
++S S D T +W
Sbjct: 470 -QIISSSHDDTILIW 483
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 84.7 bits (208), Expect = 3e-16
Identities = 80/295 (27%), Positives = 132/295 (44%), Gaps = 34/295 (11%)
Query: 22 RGLVCCAYPPGAFVSVSRDRTTRLWAPDSPNRSFTEMHCMSGHSNFVSCVCIIPSSDIYP 81
+G+ C Y +S RD + ++W S + ++GH+ V C+ Y
Sbjct: 228 KGVYCLQYDDEKIISGLRDNSIKIW----DKTSLECLKVLTGHTGSVLCLQ-------YD 276
Query: 82 HGLIATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLSSGKFGTLLSGSWDTTAKVWLND 141
+I TG +D + ++ +++ L L H V L G +++ S D + VW D
Sbjct: 277 ERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSN-GLMVTCSKDRSIAVW--D 333
Query: 142 KCMMT-------LQGHTAAVWAVKILPEQGLMLTGSADKTVKLWKAGRCE--RTFSGHED 192
T L GH AAV V + +++ S D+T+K+W CE RT +GH+
Sbjct: 334 MASATDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHK- 390
Query: 193 CVRGLAILSETEFL--SCANDASIRRWQI-TGECLEVYYGHTNYIYSISVFPNCRDFVTT 249
RG+A L + L S ++D +IR W I G CL V GH + I F N R V+
Sbjct: 391 --RGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIR-FDNKR-IVSG 446
Query: 250 AEDRSLRIWKHGECAQTIRLPAQSIWCCCVLDNGDIVVGASDGIIRVFTESEDRT 304
A D +++W + A R PA ++ ++++ V ++ + S D T
Sbjct: 447 AYDGKIKVWDL-QAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDT 500
Score = 38.5 bits (88), Expect = 0.025
Identities = 36/135 (26%), Positives = 53/135 (39%), Gaps = 24/135 (17%)
Query: 13 SLRGHELDVRGLVCCAYPPGAFVSVSRDRTTRLWAPDSPNRSFTEMHCMSGHSNFVSCVC 72
+L GH+ RG+ C Y VS S D T RLW + + + GH V C+
Sbjct: 385 TLNGHK---RGIACLQYRDRLVVSGSSDNTIRLWDIECG----ACLRVLEGHEELVRCI- 436
Query: 73 IIPSSDIYPHGLIATGGNDHNICIFSLD---------SPMPLYILKGHKNTVCSLSSGKF 123
+ + I +G D I ++ L S + L L H V L +F
Sbjct: 437 ------RFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEF 490
Query: 124 GTLLSGSWDTTAKVW 138
++S S D T +W
Sbjct: 491 -QIISSSHDDTILIW 504
>gi|19913369 transducin beta-like 3 [Homo sapiens]
Length = 808
Score = 84.0 bits (206), Expect = 5e-16
Identities = 64/251 (25%), Positives = 114/251 (45%), Gaps = 33/251 (13%)
Query: 34 FVSVSRDRTTRLWAPDSPNRSFTEMHCM---SGHSNFVSCVCIIPSSDIYPHGLIATGGN 90
F S ++D++ R+W + ++ C+ SGH++ V VC + + + TG
Sbjct: 391 FASCAKDQSVRIWRMNKAG----QVMCVAQGSGHTHSVGTVCCSRLKESF----LVTGSQ 442
Query: 91 DHNICIFSLDSPM----------PLYIL-----KGHKNTVCSLSSGKFGTLLS-GSWDTT 134
D + ++ L + P+ + + H + S++ LL+ GS D T
Sbjct: 443 DCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRT 502
Query: 135 AKVWLNDKCMM--TLQGHTAAVWAVKILPEQGLMLTGSADKTVKLW--KAGRCERTFSGH 190
AK+W +C + GH +W V+ P ++ T SAD T+KLW + C +TF GH
Sbjct: 503 AKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGH 562
Query: 191 EDCVRGLAILSE-TEFLSCANDASIRRWQI-TGECLEVYYGHTNYIYSISVFPNCRDFVT 248
+ V +A +S T+ LS +D ++ W I EC+ H + ++ + +T
Sbjct: 563 DASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLDDHALT 622
Query: 249 TAEDRSLRIWK 259
A D + +WK
Sbjct: 623 GASDSRVILWK 633
Score = 75.9 bits (185), Expect = 1e-13
Identities = 67/221 (30%), Positives = 98/221 (44%), Gaps = 24/221 (10%)
Query: 16 GHELDVRGLVCCAYPPGAF-VSVSRDRTTRLW-----------APDSPNRSFTEMHCMSG 63
GH V G VCC+ +F V+ S+D T +LW APD+
Sbjct: 419 GHTHSV-GTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRC 477
Query: 64 HSNFVSCVCIIPSSDIYPHGLIATGGNDHNICIFSLDSPMPLYILKGHKNTV-CSLSSGK 122
H ++ V I P+ L+ATG D +++L L + GH+ + C S
Sbjct: 478 HDKDINSVAIAPNDK-----LLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPM 532
Query: 123 FGTLLSGSWDTTAKVW-LND-KCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLW-- 178
L + S D T K+W L D C+ T +GH A+V V + +L+ +D VKLW
Sbjct: 533 DQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTI 592
Query: 179 KAGRCERTFSGHEDCVRGL-AILSETEFLSCANDASIRRWQ 218
K C RT HED V GL + L+ A+D+ + W+
Sbjct: 593 KNNECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILWK 633
Score = 55.5 bits (132), Expect = 2e-07
Identities = 33/145 (22%), Positives = 75/145 (51%), Gaps = 11/145 (7%)
Query: 164 GLMLTGSADKTVKLWKAG--RCERTFSGHEDCVRGLAILS--ETEFLSCANDASIRRWQI 219
G++LT +AD + L++A R ++ F+G+ + V + L ++ + +N ++ +++
Sbjct: 305 GVVLTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFEL 364
Query: 220 TGECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIWKHGECAQTIRLPAQS------ 273
++ +GHT+ + ++ VF F + A+D+S+RIW+ + Q + + S
Sbjct: 365 QTSACQILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSV 424
Query: 274 -IWCCCVLDNGDIVVGASDGIIRVF 297
CC L +V G+ D ++++
Sbjct: 425 GTVCCSRLKESFLVTGSQDCTVKLW 449
Score = 52.0 bits (123), Expect = 2e-06
Identities = 62/304 (20%), Positives = 114/304 (37%), Gaps = 50/304 (16%)
Query: 31 PGAFVSVSRDR-TTRLWAPDSPNRSFTEMHCMSGHSNFVSCVCIIPSSDIYPHGLIATGG 89
PG + + D+ T R+W S +T+ C + G++ T
Sbjct: 258 PGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLA------HTAGVVLTAT 311
Query: 90 NDHNICIFSLDSPMPLYILKGHKNTVCSLSSGKFGTLLSGSWDTTAKVWLNDKCMMT--- 146
DHN+ ++ S G+ V + G D+ V N C+
Sbjct: 312 ADHNLLLYEARSLRLQKQFAGYSEEVLDVR-------FLGPEDSHVVVASNSPCLKVFEL 364
Query: 147 -------LQGHTAAVWAVKILPEQGLMLTGSADKTVKLW---KAGR--CERTFSGHEDCV 194
L GHT V A+ + + L + + D++V++W KAG+ C SGH V
Sbjct: 365 QTSACQILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSV 424
Query: 195 RGLAI--LSETEFLSCANDASIRRWQITGECLEVYYG----------------HTNYIYS 236
+ L E+ ++ + D +++ W + L H I S
Sbjct: 425 GTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINS 484
Query: 237 ISVFPNCRDFVTTAEDRSLRIWKHGEC--AQTIRLPAQSIWCCCVLDNGDIVVGAS-DGI 293
+++ PN + T ++DR+ ++W +C + +WC ++ AS DG
Sbjct: 485 VAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGT 544
Query: 294 IRVF 297
I+++
Sbjct: 545 IKLW 548
Score = 45.8 bits (107), Expect = 2e-04
Identities = 36/127 (28%), Positives = 54/127 (42%), Gaps = 6/127 (4%)
Query: 150 HTAAVWAVKILPEQGLMLTGSADKTVKLWKAGRCERT--FSGHEDCVRGLAILSETEFL- 206
HTA V + P L+ TG D V++W R T F G V +A + L
Sbjct: 108 HTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLL 167
Query: 207 --SCANDASIRRWQITG-ECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIWKHGEC 263
S A DA+IR W + CL V H + + S++ + +++ D+ IW C
Sbjct: 168 LFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSC 227
Query: 264 AQTIRLP 270
T +P
Sbjct: 228 QATRTVP 234
Score = 38.9 bits (89), Expect = 0.019
Identities = 38/160 (23%), Positives = 69/160 (43%), Gaps = 19/160 (11%)
Query: 84 LIATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLSSGKFGT---LLSGSWDTTAKVW-L 139
L+ATGG D + ++ + + +G V ++ T L S + D +VW L
Sbjct: 123 LLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSL 182
Query: 140 NDK-CMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLWKAGRCERTFSG--------- 189
D+ C+ L H +AV ++ + ML+ DK +W C+ T +
Sbjct: 183 QDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAA 242
Query: 190 ---HEDCVRGLAILSE-TEFLSCANDASIRRWQ-ITGECL 224
E+ V L + S FL+ + ++R W+ +G+C+
Sbjct: 243 VLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCV 282
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 83.2 bits (204), Expect = 9e-16
Identities = 54/182 (29%), Positives = 94/182 (51%), Gaps = 7/182 (3%)
Query: 84 LIATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLSSGKFGTLL-SGSWDTTAKVWLND- 141
L+ATGG+D + ++S++ P + L GH + V S+ L+ +GS + +VW +
Sbjct: 35 LLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEA 94
Query: 142 -KCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLWKAGR--CERTFSGHEDCVRGLA 198
K + TL GH A + ++ P + +GS D +KLW R C + GH VR L
Sbjct: 95 AKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLR 154
Query: 199 ILSETEFL-SCANDASIRRWQIT-GECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLR 256
+ ++L S A+D +++ W +T G+ + + GHT + + PN + + DR++R
Sbjct: 155 FSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIR 214
Query: 257 IW 258
W
Sbjct: 215 FW 216
Score = 67.8 bits (164), Expect = 4e-11
Identities = 44/156 (28%), Positives = 82/156 (52%), Gaps = 8/156 (5%)
Query: 111 HKNTVCSLSSGKFG--TLLSGSWDTTAKVWLNDK--CMMTLQGHTAAVWAVKILPEQGLM 166
H + V SL GK L +G D +W +K C+M+L GHT+ V +V++ + L+
Sbjct: 19 HASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELI 78
Query: 167 LTGSADKTVKLW--KAGRCERTFSGHEDCVRGLAILSETEFL-SCANDASIRRWQITGE- 222
+ GS ++++W +A + RT GH+ + L EF+ S + D +I+ W I +
Sbjct: 79 VAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKG 138
Query: 223 CLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIW 258
C+ Y GH+ + + P+ + + A+D ++++W
Sbjct: 139 CVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLW 174
Score = 57.4 bits (137), Expect = 5e-08
Identities = 50/170 (29%), Positives = 78/170 (45%), Gaps = 15/170 (8%)
Query: 13 SLRGHELDVRGLVCCAYPPGAFVSVSRDRTTRLWAPDSPNRSFTEMHCMSGHSNFVSCVC 72
SL GH V V P V+ S+ + R+W ++ T M GH + +C
Sbjct: 58 SLTGHTSPVES-VRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLM----GHK---ANIC 109
Query: 73 IIPSSDIYPHG-LIATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLSSGKFGT-LLSGS 130
S D +P+G +A+G D NI ++ + ++ +GH V L G L S +
Sbjct: 110 ---SLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAA 166
Query: 131 WDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLW 178
D T K+W K M GHT V V+ P + L+ +GS+D+T++ W
Sbjct: 167 DDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFW 216
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 82.4 bits (202), Expect = 1e-15
Identities = 69/264 (26%), Positives = 120/264 (45%), Gaps = 21/264 (7%)
Query: 48 PDSPNRSFTEMHCMSGHSNFVSCVCIIPSSDIYPHGLIATGGNDHNICIFSLDSPMPLYI 107
P PN + ++GH+ VS V P+ + +A+ D I I+
Sbjct: 30 PVKPN--YALKFTLAGHTKAVSSVKFSPNGE-----WLASSSADKLIKIWGAYDGKFEKT 82
Query: 108 LKGHKNTVCSLS-SGKFGTLLSGSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQG 164
+ GHK + ++ S L+S S D T K+W + KC+ TL+GH+ V+ P+
Sbjct: 83 ISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN 142
Query: 165 LMLTGSADKTVKLW--KAGRCERTFSGHEDCVRGLAILSETEFL-SCANDASIRRWQ-IT 220
L+++GS D++V++W K G+C +T H D V + + + S + D R W +
Sbjct: 143 LIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTAS 202
Query: 221 GECLEVYYGHTNYIYSISVF-PNCRDFVTTAEDRSLRIWKH--GECAQTIRLPAQSIWCC 277
G+CL+ N S F PN + + D +L++W + G+C +T +C
Sbjct: 203 GQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCI 262
Query: 278 ----CVLDNGDIVVGASDGIIRVF 297
V IV G+ D ++ ++
Sbjct: 263 FANFSVTGGKWIVSGSEDNLVYIW 286
Score = 41.2 bits (95), Expect = 0.004
Identities = 54/214 (25%), Positives = 86/214 (40%), Gaps = 51/214 (23%)
Query: 13 SLRGHELDVRGLVCCAYPPGA--FVSVSRDRTTRLWAPDS-------PNRS--FTEMHCM 61
+L+GH V CC + P + VS S D + R+W + P S + +H
Sbjct: 124 TLKGHSNYV---FCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN 180
Query: 62 SGHSNFVS----------------CVCIIPSSDIYPHGLIATGGNDHNICIFSLDSPMPL 105
S VS C+ + D P + N I +LD+ + L
Sbjct: 181 RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL 240
Query: 106 Y---------ILKGHKNT-VC-----SLSSGKFGTLLSGSWDTTAKVW--LNDKCMMTLQ 148
+ GHKN C S++ GK+ ++SGS D +W + + LQ
Sbjct: 241 WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKW--IVSGSEDNLVYIWNLQTKEIVQKLQ 298
Query: 149 GHTAAVWAVKILPEQGLMLTGSA--DKTVKLWKA 180
GHT V + P + ++ + + DKT+KLWK+
Sbjct: 299 GHTDVVISTACHPTENIIASAALENDKTIKLWKS 332
Score = 33.5 bits (75), Expect = 0.80
Identities = 27/119 (22%), Positives = 55/119 (46%), Gaps = 16/119 (13%)
Query: 30 PPGAFV-SVSRDRTTRLWAPDSPNRSFTEMHCM---SGHSNFVSCVCIIPSSDIYPHGLI 85
P G ++ + + D T +LW +++ C+ +GH N CI + + I
Sbjct: 224 PNGKYILAATLDNTLKLW-------DYSKGKCLKTYTGHKN--EKYCIFANFSVTGGKWI 274
Query: 86 ATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLSSGKFGTLLSGSW---DTTAKVWLND 141
+G D+ + I++L + + L+GH + V S + +++ + D T K+W +D
Sbjct: 275 VSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 333
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 82.4 bits (202), Expect = 1e-15
Identities = 69/264 (26%), Positives = 120/264 (45%), Gaps = 21/264 (7%)
Query: 48 PDSPNRSFTEMHCMSGHSNFVSCVCIIPSSDIYPHGLIATGGNDHNICIFSLDSPMPLYI 107
P PN + ++GH+ VS V P+ + +A+ D I I+
Sbjct: 30 PVKPN--YALKFTLAGHTKAVSSVKFSPNGE-----WLASSSADKLIKIWGAYDGKFEKT 82
Query: 108 LKGHKNTVCSLS-SGKFGTLLSGSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQG 164
+ GHK + ++ S L+S S D T K+W + KC+ TL+GH+ V+ P+
Sbjct: 83 ISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN 142
Query: 165 LMLTGSADKTVKLW--KAGRCERTFSGHEDCVRGLAILSETEFL-SCANDASIRRWQ-IT 220
L+++GS D++V++W K G+C +T H D V + + + S + D R W +
Sbjct: 143 LIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTAS 202
Query: 221 GECLEVYYGHTNYIYSISVF-PNCRDFVTTAEDRSLRIWKH--GECAQTIRLPAQSIWCC 277
G+CL+ N S F PN + + D +L++W + G+C +T +C
Sbjct: 203 GQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCI 262
Query: 278 ----CVLDNGDIVVGASDGIIRVF 297
V IV G+ D ++ ++
Sbjct: 263 FANFSVTGGKWIVSGSEDNLVYIW 286
Score = 41.2 bits (95), Expect = 0.004
Identities = 54/214 (25%), Positives = 86/214 (40%), Gaps = 51/214 (23%)
Query: 13 SLRGHELDVRGLVCCAYPPGA--FVSVSRDRTTRLWAPDS-------PNRS--FTEMHCM 61
+L+GH V CC + P + VS S D + R+W + P S + +H
Sbjct: 124 TLKGHSNYV---FCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN 180
Query: 62 SGHSNFVS----------------CVCIIPSSDIYPHGLIATGGNDHNICIFSLDSPMPL 105
S VS C+ + D P + N I +LD+ + L
Sbjct: 181 RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL 240
Query: 106 Y---------ILKGHKNT-VC-----SLSSGKFGTLLSGSWDTTAKVW--LNDKCMMTLQ 148
+ GHKN C S++ GK+ ++SGS D +W + + LQ
Sbjct: 241 WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKW--IVSGSEDNLVYIWNLQTKEIVQKLQ 298
Query: 149 GHTAAVWAVKILPEQGLMLTGSA--DKTVKLWKA 180
GHT V + P + ++ + + DKT+KLWK+
Sbjct: 299 GHTDVVISTACHPTENIIASAALENDKTIKLWKS 332
Score = 33.5 bits (75), Expect = 0.80
Identities = 27/119 (22%), Positives = 55/119 (46%), Gaps = 16/119 (13%)
Query: 30 PPGAFV-SVSRDRTTRLWAPDSPNRSFTEMHCM---SGHSNFVSCVCIIPSSDIYPHGLI 85
P G ++ + + D T +LW +++ C+ +GH N CI + + I
Sbjct: 224 PNGKYILAATLDNTLKLW-------DYSKGKCLKTYTGHKN--EKYCIFANFSVTGGKWI 274
Query: 86 ATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLSSGKFGTLLSGSW---DTTAKVWLND 141
+G D+ + I++L + + L+GH + V S + +++ + D T K+W +D
Sbjct: 275 VSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 333
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 80.9 bits (198), Expect = 4e-15
Identities = 72/250 (28%), Positives = 115/250 (46%), Gaps = 35/250 (14%)
Query: 22 RGLVCCAYPPGAFVSVSRDRTTRLWAPDSPNRSFTEMHC---MSGHSNFVSCVCIIPSSD 78
+G+ C Y VS RD T ++W ++ + C ++GH+ V C+
Sbjct: 268 KGVYCLQYDDQKIVSGLRDNTIKIWDKNT-------LECKRILTGHTGSVLCLQ------ 314
Query: 79 IYPHGLIATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLSSGKFGTLLSGSWDTTAKVW 138
Y +I TG +D + ++ +++ L L H V L G +++ S D + VW
Sbjct: 315 -YDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNN-GMMVTCSKDRSIAVW 372
Query: 139 -----LNDKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLWKAGRCE--RTFSGHE 191
+ L GH AAV V + +++ S D+T+K+W CE RT +GH+
Sbjct: 373 DMASPTDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHK 430
Query: 192 DCVRGLAILSETEFL--SCANDASIRRWQI-TGECLEVYYGHTNYIYSISVFPNCRDFVT 248
RG+A L + L S ++D +IR W I G CL V GH + I F N R V+
Sbjct: 431 ---RGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIR-FDNKR-IVS 485
Query: 249 TAEDRSLRIW 258
A D +++W
Sbjct: 486 GAYDGKIKVW 495
Score = 58.9 bits (141), Expect = 2e-08
Identities = 46/181 (25%), Positives = 83/181 (45%), Gaps = 14/181 (7%)
Query: 126 LLSGSWDTTAKVWLND--KCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLW--KAG 181
++SG D T K+W + +C L GHT +V ++ ++ +++TGS+D TV++W G
Sbjct: 280 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWDVNTG 337
Query: 182 RCERTFSGHEDCVRGLAILSETEFLSCANDASIRRWQITGEC----LEVYYGHTNYIYSI 237
T H + V L + ++C+ D SI W + V GH + +
Sbjct: 338 EMLNTLIHHCEAVLHLRF-NNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVV 396
Query: 238 SVFPNCRDFVTTAEDRSLRIWKHGECAQTIRLPAQSIWCCCVLDNGDIVV-GASDGIIRV 296
+ + V+ + DR++++W C L C+ +VV G+SD IR+
Sbjct: 397 DF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRL 454
Query: 297 F 297
+
Sbjct: 455 W 455
Score = 38.1 bits (87), Expect = 0.032
Identities = 40/140 (28%), Positives = 57/140 (40%), Gaps = 26/140 (18%)
Query: 13 SLRGHELDVRGLVCCAYPPGAFVSVSRDRTTRLWAPDSPNRSFTEMHCMSGHSNFVSCVC 72
+L GH+ RG+ C Y VS S D T RLW + + + GH V C+
Sbjct: 425 TLNGHK---RGIACLQYRDRLVVSGSSDNTIRLWDIECG----ACLRVLEGHEELVRCI- 476
Query: 73 IIPSSDIYPHGLIATGGNDHNICIF----SLDSPMP-----LYILKGHKNTVCSLSSGKF 123
+ + I +G D I ++ +LD P L L H V L +F
Sbjct: 477 ------RFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEF 530
Query: 124 GTLLSGSWDTTAKVW--LND 141
++S S D T +W LND
Sbjct: 531 -QIVSSSHDDTILIWDFLND 549
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 80.9 bits (198), Expect = 4e-15
Identities = 72/250 (28%), Positives = 115/250 (46%), Gaps = 35/250 (14%)
Query: 22 RGLVCCAYPPGAFVSVSRDRTTRLWAPDSPNRSFTEMHC---MSGHSNFVSCVCIIPSSD 78
+G+ C Y VS RD T ++W ++ + C ++GH+ V C+
Sbjct: 304 KGVYCLQYDDQKIVSGLRDNTIKIWDKNT-------LECKRILTGHTGSVLCLQ------ 350
Query: 79 IYPHGLIATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLSSGKFGTLLSGSWDTTAKVW 138
Y +I TG +D + ++ +++ L L H V L G +++ S D + VW
Sbjct: 351 -YDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNN-GMMVTCSKDRSIAVW 408
Query: 139 -----LNDKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLWKAGRCE--RTFSGHE 191
+ L GH AAV V + +++ S D+T+K+W CE RT +GH+
Sbjct: 409 DMASPTDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHK 466
Query: 192 DCVRGLAILSETEFL--SCANDASIRRWQI-TGECLEVYYGHTNYIYSISVFPNCRDFVT 248
RG+A L + L S ++D +IR W I G CL V GH + I F N R V+
Sbjct: 467 ---RGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIR-FDNKR-IVS 521
Query: 249 TAEDRSLRIW 258
A D +++W
Sbjct: 522 GAYDGKIKVW 531
Score = 58.9 bits (141), Expect = 2e-08
Identities = 46/181 (25%), Positives = 83/181 (45%), Gaps = 14/181 (7%)
Query: 126 LLSGSWDTTAKVWLND--KCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLW--KAG 181
++SG D T K+W + +C L GHT +V ++ ++ +++TGS+D TV++W G
Sbjct: 316 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWDVNTG 373
Query: 182 RCERTFSGHEDCVRGLAILSETEFLSCANDASIRRWQITGEC----LEVYYGHTNYIYSI 237
T H + V L + ++C+ D SI W + V GH + +
Sbjct: 374 EMLNTLIHHCEAVLHLRF-NNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVV 432
Query: 238 SVFPNCRDFVTTAEDRSLRIWKHGECAQTIRLPAQSIWCCCVLDNGDIVV-GASDGIIRV 296
+ + V+ + DR++++W C L C+ +VV G+SD IR+
Sbjct: 433 DF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRL 490
Query: 297 F 297
+
Sbjct: 491 W 491
Score = 38.1 bits (87), Expect = 0.032
Identities = 40/140 (28%), Positives = 57/140 (40%), Gaps = 26/140 (18%)
Query: 13 SLRGHELDVRGLVCCAYPPGAFVSVSRDRTTRLWAPDSPNRSFTEMHCMSGHSNFVSCVC 72
+L GH+ RG+ C Y VS S D T RLW + + + GH V C+
Sbjct: 461 TLNGHK---RGIACLQYRDRLVVSGSSDNTIRLWDIECG----ACLRVLEGHEELVRCI- 512
Query: 73 IIPSSDIYPHGLIATGGNDHNICIF----SLDSPMP-----LYILKGHKNTVCSLSSGKF 123
+ + I +G D I ++ +LD P L L H V L +F
Sbjct: 513 ------RFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEF 566
Query: 124 GTLLSGSWDTTAKVW--LND 141
++S S D T +W LND
Sbjct: 567 -QIVSSSHDDTILIWDFLND 585
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 80.9 bits (198), Expect = 4e-15
Identities = 68/244 (27%), Positives = 111/244 (45%), Gaps = 26/244 (10%)
Query: 27 CAYPPGA--FVSVSRDRTTRLWAPDSPNRSFTEMHCMSGHSNFVSCVCIIPSSDIYPHGL 84
C + P F S S D T RLW + + GH V V P S
Sbjct: 69 CRFSPDGHLFASASCDCTVRLWDVARAKC----LRVLKGHQRSVETVSFSPDSR-----Q 119
Query: 85 IATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLS-SGKFGTLLSGSWDTTAKVWLNDKC 143
+A+GG D + ++ + S L +L GH++++ S S L +GSWD+T +W D
Sbjct: 120 LASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIW--DLR 177
Query: 144 MMT-------LQGHTAAVWAVKILPEQGLMLTGSADKTVKLWKAGRCERTFS--GHEDCV 194
M+T L+GH+A + + GL+ +GS DKT+ +WK GH V
Sbjct: 178 MVTPAVSHQALEGHSANISCL-CYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWV 236
Query: 195 RGLAILSETEFLSCAN-DASIRRWQI-TGECLEVYYGHTNYIYSISVFPNCRDFVTTAED 252
+ +A + +L+ A ++ W TG+CLE G + ++ + P+ + V+ A D
Sbjct: 237 KSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAAD 296
Query: 253 RSLR 256
++ R
Sbjct: 297 QTRR 300
Score = 60.1 bits (144), Expect = 8e-09
Identities = 64/270 (23%), Positives = 110/270 (40%), Gaps = 18/270 (6%)
Query: 74 IPSSDIYPHG-LIATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLSSGKFGTLL-SGSW 131
+ SS P G ++ TG D + + S L+ L GH V G L S S
Sbjct: 24 VNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASC 83
Query: 132 DTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLW--KAGRCERTF 187
D T ++W KC+ L+GH +V V P+ + +G DK V LW ++G+ R
Sbjct: 84 DCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLL 143
Query: 188 SGHEDCVRGLAILSETEFLSCAN-DASIRRWQ-------ITGECLEVYYGHTNYIYSISV 239
GH D ++ L+ + D+++ W ++ + LE GH+ I S
Sbjct: 144 VGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALE---GHSANI-SCLC 199
Query: 240 FPNCRDFVTTAEDRSLRIWKHGECAQTIRLPAQSIWCCCVLDNGDIVVGASDGIIRVFTE 299
+ + + D+++ IWK + I+L W + + D + AS G R+
Sbjct: 200 YSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKV 259
Query: 300 SEDRTASAEEIKAFEKELSHATIDSKTGDL 329
+ T E +++H + G +
Sbjct: 260 WDCNTGKCLETLKGVLDVAHTCAFTPDGKI 289
Score = 58.5 bits (140), Expect = 2e-08
Identities = 51/203 (25%), Positives = 82/203 (40%), Gaps = 23/203 (11%)
Query: 14 LRGHELDVRGLVCCAYPPGA--FVSVSRDRTTRLWAPDSPNRSFTEMHCMSGHSNFVSCV 71
L+GH+ R + ++ P + S D+ LW S + + GH + +
Sbjct: 101 LKGHQ---RSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM----LRLLVGHRDSIQ-- 151
Query: 72 CIIPSSDIYPH-GLIATGGNDHNICIFSLDSPMPLY---ILKGHKNTVCSLSSGKFGTLL 127
SSD P +ATG D + I+ L P L+GH + L G L
Sbjct: 152 ----SSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLA 207
Query: 128 SGSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLW--KAGRC 183
SGSWD T +W ++ L+GH V ++ P++ + + + VK+W G+C
Sbjct: 208 SGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKC 267
Query: 184 ERTFSGHEDCVRGLAILSETEFL 206
T G D A + + L
Sbjct: 268 LETLKGVLDVAHTCAFTPDGKIL 290
Score = 45.4 bits (106), Expect = 2e-04
Identities = 29/113 (25%), Positives = 51/113 (45%), Gaps = 4/113 (3%)
Query: 150 HTAAVWAVKILPEQGLMLTGSADKTVKLW--KAGRCERTFSGHEDCVRGLAILSETE-FL 206
H V + P+ ++LTGS D V W ++G+ GH V+ + F
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 207 SCANDASIRRWQIT-GECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIW 258
S + D ++R W + +CL V GH + ++S P+ R + D+ + +W
Sbjct: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLW 132
>gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)
[Homo sapiens]
Length = 906
Score = 79.3 bits (194), Expect = 1e-14
Identities = 66/272 (24%), Positives = 122/272 (44%), Gaps = 19/272 (6%)
Query: 85 IATGGNDHNICIFSLDSPMPLYILKGHKNTV-CSLSSGKFGTLLSGSWDTTAKVWLNDK- 142
+ TG +D I +F+ ++ +++ + H + + C +L+ S D K+W DK
Sbjct: 72 VVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKK 131
Query: 143 --CMMTLQGHTAAVWAVKILP-EQGLMLTGSADKTVKLWKAGRCERTFS--GHE---DCV 194
C +GHT V + I P + + S D+T+K+W+ G F+ GHE +C+
Sbjct: 132 WSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCI 191
Query: 195 RGLAILSETEFLSCANDASIRRWQITGE-CLEVYYGHTNYIYSISVFPNCRDFVTTAEDR 253
+ + +S A+D ++ W + C++ GH + S P +T +ED
Sbjct: 192 DYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDG 251
Query: 254 SLRIWKHG--ECAQTIRLPAQSIWCCCVL-DNGDIVVGASDGIIRVFTESED----RTAS 306
++RIW T+ + +WC L + ++ +G +G I V E+ A+
Sbjct: 252 TVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSIIVKLGREEPAMSMDAN 311
Query: 307 AEEIKAFEKELSHATIDSKTGDLGDINAEQLP 338
+ I A E+ A + + GD + E+LP
Sbjct: 312 GKIIWAKHSEVQQANLKA-MGDAEIKDGERLP 342
Score = 68.2 bits (165), Expect = 3e-11
Identities = 49/168 (29%), Positives = 79/168 (47%), Gaps = 15/168 (8%)
Query: 29 YPPGAFVSVSRD-RTTRLWAPDSPNRSFTEMHCMSGHSNFVSCVCIIPSSDIYPHGLIAT 87
+P F+ S D +LW D + ++ GH+++V + I P + A+
Sbjct: 108 HPTQPFILTSSDDMLIKLWDWD---KKWSCSQVFEGHTHYVMQIVINPKDN----NQFAS 160
Query: 88 GGNDHNICIFSLDSPMPLYILKGHK---NTVCSLSSGKFGTLLSGSWDTTAKVW--LNDK 142
D I ++ L S P + L+GH+ N + S G L+SG+ D K+W N
Sbjct: 161 ASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKT 220
Query: 143 CMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLWKAG--RCERTFS 188
C+ TL+GH V PE +++TGS D TV++W + R E T +
Sbjct: 221 CVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTLN 268
Score = 52.0 bits (123), Expect = 2e-06
Identities = 49/186 (26%), Positives = 80/186 (43%), Gaps = 19/186 (10%)
Query: 11 SCS--LRGHELDVRGLVCCAYPPGAFVSVSRDRTTRLWAPDSPNRSFTEMHCMSGHSNFV 68
SCS GH V +V F S S DRT ++W S + +FT + GH V
Sbjct: 133 SCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFT----LEGHEKGV 188
Query: 69 SCVCIIPSSDIYPHG---LIATGGNDHNICIFSLDSPMPLYILKGH-KNTVCSLSSGKFG 124
+C+ D Y G + +G +D + I+ + + L+GH +N C+ +
Sbjct: 189 NCI------DYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELP 242
Query: 125 TLLSGSWDTTAKVWLND--KCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLWKAGR 182
+++GS D T ++W + + TL VW V L + G + ++ + K GR
Sbjct: 243 IIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSI-IVKLGR 301
Query: 183 CERTFS 188
E S
Sbjct: 302 EEPAMS 307
Score = 33.5 bits (75), Expect = 0.80
Identities = 30/126 (23%), Positives = 61/126 (48%), Gaps = 7/126 (5%)
Query: 147 LQGHTAAVWAVKILPEQGLMLTGSADKTVKLW--KAGRCERTFSGHEDCVRGLAILSETE 204
L + V +V + P + ML + +V +W + +TF + VR ++
Sbjct: 11 LTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKN 70
Query: 205 FL-SCANDASIRRWQI-TGECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIW---K 259
++ + A+D IR + T E + ++ H++YI I+V P +T+++D +++W K
Sbjct: 71 WVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDK 130
Query: 260 HGECAQ 265
C+Q
Sbjct: 131 KWSCSQ 136
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 77.8 bits (190), Expect = 4e-14
Identities = 59/190 (31%), Positives = 89/190 (46%), Gaps = 19/190 (10%)
Query: 8 YRLSCSLRGHELDVRGLVCCAYPP--GAFVSVSRDRTTRLWAPDSPNRSFTEMHCMSGHS 65
Y+L R HEL V C + P VS DR ++ N T GH+
Sbjct: 342 YKLKNIFRLHELPVS---CVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGF----GHT 394
Query: 66 NFVSCVCIIPSSDIYPHGLIATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLSSGKFGT 125
+++S C PS D +AT D + ++ L + +GH V S + G
Sbjct: 395 DWLSDCCFHPSGD-----KLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGN 449
Query: 126 LL-SGSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLWKA-- 180
+ S S D T+K+W +++C TL GHT +V +++ P +LT SADKT+ +W A
Sbjct: 450 FVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDART 509
Query: 181 GRCERTFSGH 190
G CE++ GH
Sbjct: 510 GICEQSLYGH 519
Score = 63.5 bits (153), Expect = 7e-10
Identities = 49/150 (32%), Positives = 71/150 (47%), Gaps = 8/150 (5%)
Query: 126 LLSGSWDTTAKVWLNDKC--MMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLWKA--G 181
L+S D KV KC ++T GHT + P + T S D TVKLW G
Sbjct: 367 LVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKG 426
Query: 182 RCERTFSGHEDCVRGLAILSETEFLSCAN-DASIRRWQITGE-CLEVYYGHTNYIYSISV 239
C TF GH V S F++ ++ D + + W + E C YGHT+ + SI
Sbjct: 427 DCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEF 486
Query: 240 FPNCRDFVTTAEDRSLRIW--KHGECAQTI 267
FP +T++ D++L IW + G C Q++
Sbjct: 487 FPFSNTLLTSSADKTLSIWDARTGICEQSL 516
Score = 41.2 bits (95), Expect = 0.004
Identities = 34/158 (21%), Positives = 71/158 (44%), Gaps = 13/158 (8%)
Query: 141 DKCMMTLQGHTA-AVWAVKILPEQGLMLTGSADKTVKLWKAGRCERTFSGHEDCVRGLAI 199
+KC ++G+T + + + + P L ++ + K + + F HE V +++
Sbjct: 303 NKCKTKMKGNTKDSEFPIDMQPNPNLNVSKESLSPAKF--DYKLKNIFRLHELPVSCVSM 360
Query: 200 LSETEFL-SCANDASIRRWQITG----ECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRS 254
+ L SC D R W++ G L +GHT+++ P+ T++ D +
Sbjct: 361 QPHKDILVSCGED---RLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTT 417
Query: 255 LRIWK--HGECAQTIRLPAQSIWCCCVLDNGDIVVGAS 290
+++W G+C T ++++W C G+ V +S
Sbjct: 418 VKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSS 455
>gi|5803221 WD repeat-containing protein 3 [Homo sapiens]
Length = 943
Score = 76.6 bits (187), Expect = 8e-14
Identities = 59/166 (35%), Positives = 83/166 (50%), Gaps = 13/166 (7%)
Query: 61 MSGHSNFVSCVCIIPSSDIYPHGL-IATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLS 119
+ G V+C+C PS P GL +A G D +I IFSL S GHK + +L
Sbjct: 61 LQGLKQEVTCLC--PS----PDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLK 114
Query: 120 SGKF-GTLLSGSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVK 176
+ G L SGS DT VW +N+ + L+GH A+ L E+ L++T D VK
Sbjct: 115 YDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVK 174
Query: 177 LW--KAGRCERTFSGHEDCVRGLAILSETE-FLSCANDASIRRWQI 219
W C +T GH V GL +LSE + ++ A+D+ +R W I
Sbjct: 175 WWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI 220
Score = 68.2 bits (165), Expect = 3e-11
Identities = 41/134 (30%), Positives = 71/134 (52%), Gaps = 6/134 (4%)
Query: 132 DTTAKVWLND--KCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLWKA--GRCERTF 187
D T K++ D K ++L GH V + I + L+ TGSAD+ VK+W G C ++
Sbjct: 570 DCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSL 629
Query: 188 SGHEDCVRGLAILSETE-FLSCANDASIRRWQITG-ECLEVYYGHTNYIYSISVFPNCRD 245
H+D V L + ++ F + D I++W E ++ GH I+ ++V P+
Sbjct: 630 FAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDY 689
Query: 246 FVTTAEDRSLRIWK 259
V+++ D+SLR+W+
Sbjct: 690 VVSSSHDKSLRLWE 703
Score = 55.8 bits (133), Expect = 1e-07
Identities = 42/173 (24%), Positives = 76/173 (43%), Gaps = 7/173 (4%)
Query: 93 NICIFSLDSPMPLYILKGHKNTVCSLSSGKFGTLLS-GSWDTTAKVW--LNDKCMMTLQG 149
++ I+ L + IL+G K V L G L+ G D + +++ L+ + +T G
Sbjct: 46 HVFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNG 105
Query: 150 HTAAVWAVKILPEQGLMLTGSADKTVKLWKAGRCERTF--SGHEDCVRGLAILSETEFL- 206
H AA+ +K G + +GS D + +W + GH+D + L E L
Sbjct: 106 HKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLV 165
Query: 207 SCANDASIRRWQI-TGECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIW 258
+ D ++ W + T C + GH ++ + + + +T A D LR+W
Sbjct: 166 TSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVW 218
Score = 50.4 bits (119), Expect = 6e-06
Identities = 53/184 (28%), Positives = 87/184 (47%), Gaps = 16/184 (8%)
Query: 5 ATRYRLSCS-LRGHELDVRGLVCCAYPPGA-FVSVSR-DRTTRLWAPDSPNRSFTEMHCM 61
+T+ RLS R +LD ++C +Y P ++VS D T +++ D+ + F ++
Sbjct: 533 STQKRLSVKQTRTLQLD-EDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTL-KFFLSLY-- 588
Query: 62 SGHSNFVSCVCIIPSSDIYPHGLIATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLSS- 120
GH V C+ I + LIATG D N+ I+ LD L H ++V L
Sbjct: 589 -GHKLPVICMDIS-----HDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFV 642
Query: 121 GKFGTLLSGSWDTTAKVWLNDKC--MMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLW 178
K + D K W DK + TL+GH +W + + P +++ S DK+++LW
Sbjct: 643 PKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLW 702
Query: 179 KAGR 182
+ R
Sbjct: 703 ERTR 706
Score = 42.7 bits (99), Expect = 0.001
Identities = 53/250 (21%), Positives = 94/250 (37%), Gaps = 65/250 (26%)
Query: 134 TAKVWLND----KCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLWKAGRCERTFSG 189
T K+ L D + T+ H A+W++ + P+Q +TG ADK+VK W + S
Sbjct: 475 TGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENST 534
Query: 190 HED-CVRGLAILSETEFLSCAN-------------DASIRRWQI-TGECLEVYYGHTNYI 234
+ V+ L E + C + D +++ + + T + YGH +
Sbjct: 535 QKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPV 594
Query: 235 YSISVFPNCRDFVTTAEDRSLRIW--KHGEC----------------------------- 263
+ + + T + DR+++IW G+C
Sbjct: 595 ICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKD 654
Query: 264 -------------AQTIRLPAQSIWCCCVLDNGDIVVGAS-DGIIRVFTESEDRTASAEE 309
QT+ Q IWC V +GD VV +S D +R++ + + EE
Sbjct: 655 HKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTREPLILEEE 714
Query: 310 IKAFEKELSH 319
+ E+E +
Sbjct: 715 -REMEREAEY 723
Score = 40.4 bits (93), Expect = 0.007
Identities = 27/117 (23%), Positives = 58/117 (49%), Gaps = 5/117 (4%)
Query: 145 MTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLWKAG--RCERTFSGHEDCVRGLAILSE 202
+T+ GH + V + + +L+ +AD ++K+W +C RT + E + + +
Sbjct: 409 ITIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNRSTLQCIRTMTC-EYALCSFFVPGD 466
Query: 203 TEFLSCANDASIRRWQI-TGECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIW 258
+ + ++ + + +G LE H ++S+S+ P+ R FVT D+S++ W
Sbjct: 467 RQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFW 523
>gi|4759276 RNA, U3 small nucleolar interacting protein 2 [Homo
sapiens]
Length = 475
Score = 75.9 bits (185), Expect = 1e-13
Identities = 74/273 (27%), Positives = 118/273 (43%), Gaps = 31/273 (11%)
Query: 14 LRGHELDVRGLVCCAYPPGAFVSVSRDRTTRLWAPDSPNRSFTEMHCMSG-------HSN 66
LRGH+L + LV A S ++D + W+ +S + G HS+
Sbjct: 142 LRGHQLSITCLVVTP-DDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSS 200
Query: 67 FVSCVCIIPSSDIYPHGLIATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLSSGKFGT- 125
V C+ I SSD +A+G I I+ S LY GH++ V L+ + GT
Sbjct: 201 HVLCMAI--SSD---GKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRR-GTH 254
Query: 126 -LLSGSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLWK-AG 181
L S S D + KVW + + TL GH AV A+ L + + G D TV++WK
Sbjct: 255 QLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPE 314
Query: 182 RCERTFSGHEDCVRGLAILSETEFLSCANDASIRRWQIT------------GECLEVYYG 229
+ F GH+ + + +++E +S A+D S+ W ++ G E
Sbjct: 315 ESQLVFYGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLE 374
Query: 230 HTNYIYSISVFPNCRDFVTTAEDRSLRIWKHGE 262
+I S++ N T + +R+W+ GE
Sbjct: 375 QPFWISSVAALLNTDLVATGSHSSCVRLWQCGE 407
Score = 69.7 bits (169), Expect = 1e-11
Identities = 60/270 (22%), Positives = 115/270 (42%), Gaps = 38/270 (14%)
Query: 39 RDRTTRLWAPDSPNRSFTEMHCMSGHSNFVSCVCIIPSSDIYPHGLIATGGNDHNICIFS 98
R R +L A + + ++ + GH ++C+ + P I + D +I +S
Sbjct: 120 RGRLQKLVAKEIQAPASADIRVLRGHQLSITCLVVTPDD-----SAIFSAAKDCSIIKWS 174
Query: 99 LDSPMPLYILKGHKNTVCSLSSGKFGTLLSGSWDTTAKVWLNDKCMMTLQGHTAAVWAVK 158
++S L+++ K + GK GH++ V +
Sbjct: 175 VESGRKLHVIPRAKKG----AEGK------------------------PPGHSSHVLCMA 206
Query: 159 ILPEQGLMLTGSADKTVKLWKAGRCER--TFSGHEDCVRGLAILSET-EFLSCANDASIR 215
I + + +G K + +W+A C+ TF+GH D V GLA T + S ++D S++
Sbjct: 207 ISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVK 266
Query: 216 RWQIT-GECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIWKHGECAQTIRLPAQ-S 273
W + +E +GH + + ++ D ++R+WK E +Q + Q S
Sbjct: 267 VWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQLVFYGHQGS 326
Query: 274 IWCCCVLDNGDIVVGASDGIIRVFTESEDR 303
I C +++ +V GA DG + ++ S+ R
Sbjct: 327 IDCIHLINEEHMVSGADDGSVALWGLSKKR 356
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 74.7 bits (182), Expect = 3e-13
Identities = 65/289 (22%), Positives = 116/289 (40%), Gaps = 51/289 (17%)
Query: 29 YPPGAFVSVSRDRTTRLWAPDSPNRSFTEMHCMSGHSNFVSCVCIIPSSDIYPHGLIATG 88
YPPG V+++ D T++ M S S +P A
Sbjct: 100 YPPGPGVALTAD---------------TKIQRMPSESAAQSLAVALPLQTKADANRTAPS 144
Query: 89 GNDHNICIFSLDSPMPL----YILKGHKNTVCSLSSGKFGTLLSGSWDTTAKVWLNDKCM 144
G+++ S D P P +++ +L + K T+ W K++
Sbjct: 145 GSEYRHPGAS-DRPQPTAMNSIVMETGNTKNSALMAKKAPTMPKPQWHPPWKLY------ 197
Query: 145 MTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLW--KAGRCERTFSGHEDCVRGLAILSE 202
+ GH V + + P +TGSAD+T+K+W +G+ + + +GH VRG+ + +
Sbjct: 198 RVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTR 257
Query: 203 TEFL-SCANDASIRRWQIT-GECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIWK- 259
+ +L SC D ++ W + + + Y+GH + +Y + + P VT + D + RIW
Sbjct: 258 SPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDV 317
Query: 260 -----------HGECAQTIRLPAQSIWCCCVLDNGDIVVGASDGIIRVF 297
H T+R C I+ G+ D IR++
Sbjct: 318 RTKASVHTLSGHTNAVATVR---------CQAAEPQIITGSHDTTIRLW 357
Score = 73.2 bits (178), Expect = 9e-13
Identities = 71/304 (23%), Positives = 132/304 (43%), Gaps = 29/304 (9%)
Query: 26 CCAYPPGA--FVSVSRDRTTRLWAPDSPNRSFTEMHCMSGHSNFVSCVCIIPSSDIYPHG 83
C A PG FV+ S DRT ++W S + ++GH + V V + S
Sbjct: 209 CIAVEPGNQWFVTGSADRTIKIWDLASGKLKLS----LTGHISTVRGVIVSTRSPY---- 260
Query: 84 LIATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLS-SGKFGTLLSGSWDTTAKVW--LN 140
+ + G D + + L+ + GH + V L L++ S D+TA++W
Sbjct: 261 -LFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRT 319
Query: 141 DKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLWK--AGRCERTFSGHEDCVRGLA 198
+ TL GHT AV V+ + ++TGS D T++LW AG+ T + H+ VR +
Sbjct: 320 KASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVV 379
Query: 199 ILSETEFLSCANDASIRRWQI-TGECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRI 257
+ + + +I++W+ G ++ GH I +++V + V+ A++ ++ +
Sbjct: 380 LHPRHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSD-GVLVSGADNGTMHL 438
Query: 258 W---------KHGECAQTIRLPAQSIWCCCVLDNGD--IVVGASDGIIRVFTESEDRTAS 306
W + Q L ++S C D + ++ +D I+V+ E + T
Sbjct: 439 WDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVYREDDTATEE 498
Query: 307 AEEI 310
+
Sbjct: 499 THPV 502
Score = 68.2 bits (165), Expect = 3e-11
Identities = 57/214 (26%), Positives = 97/214 (45%), Gaps = 16/214 (7%)
Query: 9 RLSCSLRGHELDVRGLVCCAYPPGAFVSVSRDRTTRLWAPDSPNRSFTEMHCMSGHSNFV 68
+L SL GH VRG++ P F S D+ + W + N+ H GH + V
Sbjct: 237 KLKLSLTGHISTVRGVIVSTRSPYLF-SCGEDKQVKCWDLEY-NKVIRHYH---GHLSAV 291
Query: 69 SCVCIIPSSDIYPHGLIATGGNDHNICIFSLDSPMPLYILKGHKNTVCSL-SSGKFGTLL 127
+ + P+ D+ + T D I+ + + ++ L GH N V ++ ++
Sbjct: 292 YGLDLHPTIDV-----LVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQII 346
Query: 128 SGSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLWK--AGRC 183
+GS DTT ++W + K +TL H +V AV + P +GS D +K WK G
Sbjct: 347 TGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPD-NIKQWKFPDGSF 405
Query: 184 ERTFSGHEDCVRGLAILSETEFLSCANDASIRRW 217
+ SGH + L + S+ +S A++ ++ W
Sbjct: 406 IQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLW 439
>gi|8923881 WD SOCS-box protein 2 [Homo sapiens]
Length = 404
Score = 74.7 bits (182), Expect = 3e-13
Identities = 69/273 (25%), Positives = 113/273 (41%), Gaps = 36/273 (13%)
Query: 48 PDSPNRSFTEMHCMSGHSNFVSCVCIIPSSDIYPHGLIATGGNDHNICIFSLDSPMPLYI 107
P P+R H H C++ +ATG ND I I+ + + + L
Sbjct: 103 PSPPSRKLWARH----HPQVPDVSCLV----------LATGLNDGQIKIWEVQTGLLLLN 148
Query: 108 LKGHKNTVCSLSSGKFGTLL--SGSWDTTAKVW---LNDKCMMTLQGHTAAVWAVKILPE 162
L GH++ V LS G+L+ S S D T ++W + K + L GH V+ I P+
Sbjct: 149 LSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQIQVLSGHLQWVYCCSISPD 208
Query: 163 QGLMLTGSADKTVKLW--KAGRCERTFSGHEDCVRGLAILSETEFLSCAN-DASIRRWQ- 218
++ + + +K+V LW ++ R GH+ V ++ L A+ D ++ W
Sbjct: 209 CSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDP 268
Query: 219 ITGECLEVYYG------------HTNYIYSISVFPNCRDFVTTAEDRSLRIWKHGECAQT 266
TGE L + H + + S+ P T A+DR LRIW
Sbjct: 269 YTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEGLYLATVADDRLLRIWALELKTPI 328
Query: 267 IRLPAQSIWCCCVLDNGDIV-VGASDGIIRVFT 298
P + CC +G ++ G DG ++ +T
Sbjct: 329 AFAPMTNGLCCTFFPHGGVIATGTRDGHVQFWT 361
Score = 54.7 bits (130), Expect = 3e-07
Identities = 41/158 (25%), Positives = 67/158 (42%), Gaps = 12/158 (7%)
Query: 109 KGHKNTVCSLSSGKFGTLLSGS--WDTTAKVWLNDKCMMTLQGHTAAVWAVKILPEQGLM 166
+ KN S K TL G W W + H V V L ++
Sbjct: 71 RSSKNETKGRGSPKEKTLDCGQIVWGLAFSPWPSPPSRKLWARHHPQVPDVSCL----VL 126
Query: 167 LTGSADKTVKLWKA--GRCERTFSGHEDCVRGLAILSETEFL--SCANDASIRRWQIT-- 220
TG D +K+W+ G SGH+D VR L+ + S + D ++R W +
Sbjct: 127 ATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKH 186
Query: 221 GECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIW 258
G+ ++V GH ++Y S+ P+C + A ++S+ +W
Sbjct: 187 GKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLW 224
Score = 53.9 bits (128), Expect = 6e-07
Identities = 45/184 (24%), Positives = 82/184 (44%), Gaps = 23/184 (12%)
Query: 10 LSCSLRGHELDVRGLVCCAYPPGAFVSVSRDRTTRLWAPDSPNRSFTEMHCMSGHSNFVS 69
L +L GH+ VR L VS SRD+T R+W N+ ++ +SGH +V
Sbjct: 145 LLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIW---DLNKHGKQIQVLSGHLQWVY 201
Query: 70 CVCIIPSSDIYPHGLIATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLS-SGKFGTLLS 128
C I P ++ + + ++ ++S+ S + L+GH+++V S S L++
Sbjct: 202 CCSISPDC-----SMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVT 256
Query: 129 GSWDTTAKVW--------------LNDKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKT 174
S+DT +W D M H +++ +V PE + T + D+
Sbjct: 257 ASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEGLYLATVADDRL 316
Query: 175 VKLW 178
+++W
Sbjct: 317 LRIW 320
>gi|5174447 guanine nucleotide binding protein (G protein), beta
polypeptide 2-like 1 [Homo sapiens]
Length = 317
Score = 74.3 bits (181), Expect = 4e-13
Identities = 64/243 (26%), Positives = 103/243 (42%), Gaps = 34/243 (13%)
Query: 61 MSGHSNFVSCVCIIPSSDIYPHGLIATGGNDHNICIFSLDSP-----MPLYILKGHKNTV 115
+ GH+ +V+ + P +P +I + D I ++ L +P L+GH + V
Sbjct: 11 LKGHNGWVTQIATTPQ---FPD-MILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFV 66
Query: 116 CSL---SSGKFGTLLSGSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQGLMLTGS 170
+ S G+F LSGSWD T ++W GHT V +V + +++GS
Sbjct: 67 SDVVISSDGQFA--LSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGS 124
Query: 171 ADKTVKLWKA-GRCERTFSGHE-----DCVRGLAILSETEFLSCANDASIRRWQITGECL 224
DKT+KLW G C+ T CVR S +SC D ++ W + L
Sbjct: 125 RDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKL 184
Query: 225 EV-YYGHTNYIYSISVFPNCRDFVTTAEDRSLRIWKHGECAQTIRLPAQSIWCCCVLDNG 283
+ + GHT Y+ +++V P+ + +D +W E LD G
Sbjct: 185 KTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLY-----------TLDGG 233
Query: 284 DIV 286
DI+
Sbjct: 234 DII 236
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 73.9 bits (180), Expect = 5e-13
Identities = 58/220 (26%), Positives = 95/220 (43%), Gaps = 20/220 (9%)
Query: 105 LYILKGHKNTVCSLS-SGKFGTLLSGSWDTTAKVWLNDK--CMMTLQGHTAAVWAVKILP 161
L IL GH V S S LLS S D T ++W C++ +GH VW + P
Sbjct: 536 LKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSP 595
Query: 162 EQGLMLTGSADKTVKLWKAGRCE--RTFSGHEDCVRGLAILSETEFLSCAN-DASIRRWQ 218
++G D+ +LW + R F+GH V + +++ + D ++R W
Sbjct: 596 YGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWD 655
Query: 219 I-TGECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIWKHGECAQTIRLPAQSIWCC 277
+ G C+ ++ GH I+S++ PN R T A D + +W G L + C
Sbjct: 656 VLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVC 715
Query: 278 CVLDNGD---IVVGASDGIIRVFTESEDRTASAEEIKAFE 314
+ + D + G+ D +R++ + IKAFE
Sbjct: 716 SLRFSRDGEILASGSMDNTVRLW----------DAIKAFE 745
Score = 54.3 bits (129), Expect = 4e-07
Identities = 46/139 (33%), Positives = 64/139 (46%), Gaps = 34/139 (24%)
Query: 34 FVSVSRDRTTRLWAPD--SPNRSFT----EMHCMSGH--SNFVS---------------- 69
FVS DR RLWA D P R F +++C H SN+V+
Sbjct: 600 FVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNG 659
Query: 70 -CVCI-------IPSSDIYPHG-LIATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLSS 120
CV I I S P+G +ATG D + ++ + + + LKGH +TVCSL
Sbjct: 660 NCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRF 719
Query: 121 GKFGTLL-SGSWDTTAKVW 138
+ G +L SGS D T ++W
Sbjct: 720 SRDGEILASGSMDNTVRLW 738
Score = 44.7 bits (104), Expect = 3e-04
Identities = 31/134 (23%), Positives = 63/134 (47%), Gaps = 16/134 (11%)
Query: 132 DTTAKVWLNDKCMMTLQGHT-----AAVWAVKILPEQGLMLTGSADKTVKLWKAGRCERT 186
+TT +V L C+ ++ +T + AV + + L+ G AD TV++W +
Sbjct: 446 ETTKRVRLGPDCLPSICFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKK-- 503
Query: 187 FSGHEDCVRGLAILSETEFLSCANDASIRRW--QITGECLEVYYGHTNYIYSISVFPNCR 244
+R + S+ + +D + R + T L++ YGH+ +Y S P+
Sbjct: 504 -------LRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRN 556
Query: 245 DFVTTAEDRSLRIW 258
++++ED ++R+W
Sbjct: 557 YLLSSSEDGTVRLW 570
>gi|157266266 WD repeat domain 86 [Homo sapiens]
Length = 376
Score = 73.6 bits (179), Expect = 7e-13
Identities = 52/168 (30%), Positives = 79/168 (47%), Gaps = 23/168 (13%)
Query: 150 HTAAVWAVKILPEQGLMLTGSADKTVKLWKA--GRCERTFSGHEDCVRGLAILSETEFLS 207
H + + + P+ +LTGS D T +LW G+C GHE V + E F +
Sbjct: 14 HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAF-T 72
Query: 208 CANDASIRRWQI-TGECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIWK------- 259
C+ D +IRRW + TG+CL+VY GHT+ + I V N +++ DR+ R+W
Sbjct: 73 CSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANN--QLFSSSYDRTARVWSVDKGQMS 130
Query: 260 -----HGECAQTIRLPA----QSIWCC-CVLDNGDIVVGASDGIIRVF 297
H C T+ A S C G +V G++DG +V+
Sbjct: 131 REFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVW 178
Score = 70.1 bits (170), Expect = 8e-12
Identities = 76/310 (24%), Positives = 129/310 (41%), Gaps = 48/310 (15%)
Query: 14 LRGHELDVRGLVCCAYPPGAFVSVSRDRTTRLWAPDSPNRSFTEMHCMSGHSNFVSCVCI 73
L+GHE V C A + S D T R W D +++ GH++ V+ + +
Sbjct: 53 LQGHESYV---TFCQLEDEAAFTCSADCTIRRW--DVLTGQCLQVY--RGHTSIVNRILV 105
Query: 74 IPSSDIYPHGLIATGGNDHNICIFSLDSPMPLYILKGHKNTV---------------CSL 118
+ + + D ++S+D +GH+N V C+
Sbjct: 106 ANNQ-------LFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAE 158
Query: 119 SSGKFGTLLSGSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVK 176
+ G L++GS D TAKVW + C TL+GHT AV + + TGS D T++
Sbjct: 159 EAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIR 218
Query: 177 LWK--AGRCERTFSGHEDCVRGLAILSETEFLSCANDASIRRWQI-TGECLEVYYGHTNY 233
W +G R F H V L +++ + A D +++ W TGEC+ + H
Sbjct: 219 AWDILSGEQLRVFREHRGSVICLELVNRLVYSGSA-DRTVKCWLADTGECVRTFTAHRRN 277
Query: 234 IYSI-----SVFPNCRDFVTTAEDRSLRIWKHGECAQTIRLPAQSIWCCCVLDNGDIVVG 288
+ ++ ++F D A D + GE + R + C+ +G ++
Sbjct: 278 VSALKYHAGTLFTGSGDACARAFDA-----QSGELRRVFR--GHTFIINCIQVHGQVLYT 330
Query: 289 AS-DGIIRVF 297
AS DG +R++
Sbjct: 331 ASHDGALRLW 340
Score = 63.5 bits (153), Expect = 7e-10
Identities = 61/235 (25%), Positives = 108/235 (45%), Gaps = 33/235 (14%)
Query: 105 LYILKGHKNTVCSLSSGKFGT-LLSGSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILP 161
L + H+ + LS G LL+GS D TA++W + +C LQGH + V ++
Sbjct: 8 LRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQL-- 65
Query: 162 EQGLMLTGSADKTVKLWK--AGRCERTFSGHEDCVRGLAILSETEFLSCANDASIRRWQI 219
E T SAD T++ W G+C + + GH V + +++ + S + D + R W +
Sbjct: 66 EDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRI-LVANNQLFSSSYDRTARVWSV 124
Query: 220 -TGECLEVYYGHTNYIYSISV-----FPN--CRD-------FVTTAEDRSLRIWK--HGE 262
G+ + GH N + +++ P+ C + VT + D + ++W+ G
Sbjct: 125 DKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGC 184
Query: 263 CAQTIRLPAQSIWCCCVLD--NGDIVVGASDGIIRVFTESEDRTASAEEIKAFEK 315
C QT+R ++ C VLD G++D IR + S E+++ F +
Sbjct: 185 CHQTLRGHTGAV-LCLVLDTPGHTAFTGSTDATIRAWD-----ILSGEQLRVFRE 233
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 72.4 bits (176), Expect = 2e-12
Identities = 58/241 (24%), Positives = 109/241 (45%), Gaps = 11/241 (4%)
Query: 74 IPSSDIYPHGL-IATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLSSGKFGTLL-SGSW 131
I S D+ P+G +AT D + +++ Y GHK+ V S+ G LL S S
Sbjct: 21 ITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASR 80
Query: 132 DTTAKVWLNDK--CMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLWKAGRCERTFS- 188
D T ++W+ DK + HTA V +V + + T S DK++K+W R +S
Sbjct: 81 DRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSL 140
Query: 189 -GHEDCVRGLAILSETEFL-SCANDASIRRWQITG-ECLEVYYGHTNYIYSISVFPNCRD 245
H VR + + SC+ D +I+ W T +C+ + + + P+
Sbjct: 141 YRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTC 200
Query: 246 FVTTAEDRSLRIW--KHGECAQTIRLPAQSIWCCCVLDNGD-IVVGASDGIIRVFTESED 302
+ D+++++W + + Q ++ + + C +G+ ++ +SDG +++ E
Sbjct: 201 IASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEG 260
Query: 303 R 303
R
Sbjct: 261 R 261
Score = 69.7 bits (169), Expect = 1e-11
Identities = 50/167 (29%), Positives = 82/167 (49%), Gaps = 9/167 (5%)
Query: 100 DSPMPLYILKGHKNTVCSLSSGKFGT-LLSGSWDTTAKVWLNDKCMMTLQ--GHTAAVWA 156
+ P+ KGHK + SL G L + SWDT +W + GH V +
Sbjct: 6 EDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTS 65
Query: 157 VKILPEQGLMLTGSADKTVKLW---KAGRCERTFSGHEDCVRGLAILSETEFLSCAN-DA 212
V+ P L+ + S D+TV+LW K G+ F H VR + ++ +FL+ A+ D
Sbjct: 66 VQFSPHGNLLASASRDRTVRLWIPDKRGKFSE-FKAHTAPVRSVDFSADGQFLATASEDK 124
Query: 213 SIRRWQITGE-CLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIW 258
SI+ W + + L Y HT+++ P+ R V+ +ED++++IW
Sbjct: 125 SIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIW 171
Score = 63.5 bits (153), Expect = 7e-10
Identities = 55/232 (23%), Positives = 98/232 (42%), Gaps = 18/232 (7%)
Query: 36 SVSRDRTTRLWAPDSPNRSFTEMHCMSGHSNFVSCVCIIPSSDIYPHG-LIATGGNDHNI 94
S SRDRT RLW PD + S F + + S D G +AT D +I
Sbjct: 77 SASRDRTVRLWIPDKRGK----------FSEFKAHTAPVRSVDFSADGQFLATASEDKSI 126
Query: 95 CIFSLDSPMPLYILKGHKNTV-CSLSSGKFGTLLSGSWDTTAKVW--LNDKCMMTLQGHT 151
++S+ LY L H + V C+ S ++S S D T K+W N +C+
Sbjct: 127 KVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSV 186
Query: 152 AAVWAVKILPEQGLMLTGSADKTVKLW--KAGRCERTFSGHEDCVRGLAILSETEFL-SC 208
V P + + +D+TVK+W + + + + H V ++ +L +
Sbjct: 187 GFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITA 246
Query: 209 ANDASIRRWQ-ITGECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIWK 259
++D +++ + G + GHT ++++S F + D + +W+
Sbjct: 247 SSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWR 298
Score = 54.3 bits (129), Expect = 4e-07
Identities = 55/180 (30%), Positives = 78/180 (43%), Gaps = 21/180 (11%)
Query: 7 RYRLSCSLRGHELDVRGLVCCAYPPGA--FVSVSRDRTTRLWAPDSPNRSFTEMHCMS-G 63
R R SL H VR C + P VS S D+T ++W D+ N+ S G
Sbjct: 133 RQRFLYSLYRHTHWVR---CAKFSPDGRLIVSCSEDKTIKIW--DTTNKQCVNNFSDSVG 187
Query: 64 HSNFVSCVCIIPSSDIYPHGL-IATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLSSGK 122
+NFV D P G IA+ G+D + ++ + L + H V +S
Sbjct: 188 FANFV---------DFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHP 238
Query: 123 FGT-LLSGSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLWK 179
G L++ S D T K+ L + + TLQGHT V+ V L +G AD V LW+
Sbjct: 239 SGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWR 298
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 71.6 bits (174), Expect = 3e-12
Identities = 80/315 (25%), Positives = 132/315 (41%), Gaps = 22/315 (6%)
Query: 36 SVSRDRTTRLWAPDSPNRSFTEMHCMSGHSNFVSCVCIIPSSDIYPHGLIATGGNDHNIC 95
S S D +W +R++ +GH + V+CV PS L+A+G D +
Sbjct: 36 SGSMDSCLMVWHMKPQSRAYR----FTGHKDAVTCVNFSPSGH-----LLASGSRDKTVR 86
Query: 96 IFSLDSPMPLYILKGHKNTVCSLSSGKFG-TLLSGSWDTTAKVWL--NDKCMMTLQGHTA 152
I+ + + + H TV S+ G + ++ S D T KVW K + +L H
Sbjct: 87 IWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHIN 146
Query: 153 AVWAVKILPEQGLMLTGSADKTVKLW-KAGR-CERTFSGHEDCVRGLAI-LSETEFLSCA 209
V K P+ L+++ S DKTVKLW K+ R C ++ H V + S T +
Sbjct: 147 WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAG 206
Query: 210 NDASIRRWQI-TGECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRI--WKHGECAQT 266
D +++ W + T L+ Y H+ + +S P+ +T + D +L+I G T
Sbjct: 207 MDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYT 266
Query: 267 IRLPAQSIWCCCVLDNGD-IVVGASDGIIRVFTESEDRTASAEEIKAFEKELSHATIDSK 325
+ G+ G SD + V+ + D E K AT+ S
Sbjct: 267 LHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKV---PRPPATLASS 323
Query: 326 TGDLGDINAEQLPGR 340
G+L +++ PGR
Sbjct: 324 MGNLPEVDFPVPPGR 338
Score = 69.7 bits (169), Expect = 1e-11
Identities = 54/203 (26%), Positives = 96/203 (47%), Gaps = 12/203 (5%)
Query: 63 GHSNFVSCVCIIPSSDIYPHGLIATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLSSGK 122
GH + V+CV ++ +A+G D + ++ + Y GHK+ V ++
Sbjct: 17 GHRDAVTCVDFSINTK-----QLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP 71
Query: 123 FGTLL-SGSWDTTAKVWL-NDKCMMTL-QGHTAAVWAVKILPEQGLMLTGSADKTVKLWK 179
G LL SGS D T ++W+ N K T+ + HTA V +V + +T S DKTVK+W
Sbjct: 72 SGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWA 131
Query: 180 AGRCERTF--SGHEDCVRGLAILSETEFL-SCANDASIRRW-QITGECLEVYYGHTNYIY 235
R + F S H + VR + + S ++D +++ W + + EC+ Y H ++
Sbjct: 132 THRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVT 191
Query: 236 SISVFPNCRDFVTTAEDRSLRIW 258
+ P+ D ++++W
Sbjct: 192 YVDFHPSGTCIAAAGMDNTVKVW 214
Score = 60.8 bits (146), Expect = 5e-09
Identities = 60/264 (22%), Positives = 105/264 (39%), Gaps = 25/264 (9%)
Query: 24 LVCCAYPPGAFV--SVSRDRTTRLWAPDSPNRSFTEMHCMSGHSNFVSCVCIIPSSDIYP 81
+ C + P + S SRD+T R+W P+ S H+ V V +
Sbjct: 64 VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV----FRAHTATVRSVHFCSDGQSF- 118
Query: 82 HGLIATGGNDHNICIFSLDSPMPLYILKGHKNTV-CSLSSGKFGTLLSGSWDTTAKVW-- 138
T +D + +++ L+ L H N V C+ S ++S S D T K+W
Sbjct: 119 ----VTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDK 174
Query: 139 LNDKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLW--KAGRCERTFSGHEDCVRG 196
+ +C+ + H V V P + D TVK+W + R + + H V G
Sbjct: 175 SSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG 234
Query: 197 LAILSETEFL-SCANDASIRRWQI-TGECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRS 254
L+ +L + ++D++++ + G L +GH +++ F + D
Sbjct: 235 LSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQ 294
Query: 255 LRIWK-------HGECAQTIRLPA 271
+ +WK HGE + R PA
Sbjct: 295 VMVWKSNFDIVDHGEVTKVPRPPA 318
Score = 59.3 bits (142), Expect = 1e-08
Identities = 55/214 (25%), Positives = 90/214 (42%), Gaps = 16/214 (7%)
Query: 11 SCSLRGHELDVRGLVCCAYPPGAFVSVSRDRTTRLWAPDSPNRSFTEMHCMSGHSNFVSC 70
S R H VR + C+ +FV+ S D+T ++WA F+ +S H N+V C
Sbjct: 96 STVFRAHTATVRSVHFCS-DGQSFVTASDDKTVKVWATHRQKFLFS----LSQHINWVRC 150
Query: 71 VCIIPSSDIYPHGLIATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLSSGKFGTLLSGS 130
P LI + +D + ++ S ++ H V + GT ++ +
Sbjct: 151 AKFSPDGR-----LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAA 205
Query: 131 -WDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKL--WKAGRCER 185
D T KVW + + Q H+AAV + P ++T S+D T+K+ GR
Sbjct: 206 GMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLY 265
Query: 186 TFSGHEDCVRGLAILSETE-FLSCANDASIRRWQ 218
T GH+ +A E F S +D + W+
Sbjct: 266 TLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 299
Score = 58.2 bits (139), Expect = 3e-08
Identities = 45/157 (28%), Positives = 75/157 (47%), Gaps = 7/157 (4%)
Query: 109 KGHKNTV-CSLSSGKFGTLLSGSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQGL 165
KGH++ V C S L SGS D+ VW GH AV V P L
Sbjct: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHL 75
Query: 166 MLTGSADKTVKLWKAG-RCERT-FSGHEDCVRGLAILSETE-FLSCANDASIRRWQI-TG 221
+ +GS DKTV++W + E T F H VR + S+ + F++ ++D +++ W
Sbjct: 76 LASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQ 135
Query: 222 ECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIW 258
+ L H N++ P+ R V+ ++D+++++W
Sbjct: 136 KFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172
>gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens]
Length = 1298
Score = 71.2 bits (173), Expect = 3e-12
Identities = 52/151 (34%), Positives = 75/151 (49%), Gaps = 17/151 (11%)
Query: 84 LIATGGNDHNICIF--SLDSPMPLYILKGHKNTVCSL--SSGKFGTLLSGSWDTTAKVW- 138
+IATG D N+ ++ + S PL + GH V + S + G L SGS D T ++W
Sbjct: 512 MIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWD 571
Query: 139 -LNDKCMMTLQGHTAAV----WAVKILPEQGLMLTGSADKTVKLW--KAGRCERTFSGHE 191
D C+ L GHTA V W +I L+++GS D T+K+W + G C T H
Sbjct: 572 YTQDACINILNGHTAPVRGLMWNTEI---PYLLISGSWDYTIKVWDTREGTCVDTVYDHG 628
Query: 192 DCVRGLAILSETEFL--SCANDASIRRWQIT 220
V GL F SC+ D+++R W +T
Sbjct: 629 ADVYGLTCHPSRPFTMASCSRDSTVRLWSLT 659
Score = 63.9 bits (154), Expect = 5e-10
Identities = 46/155 (29%), Positives = 77/155 (49%), Gaps = 13/155 (8%)
Query: 116 CSLSSGKFGTLLSGSWDTTAKVWL----NDKCMMTLQGHTAAVWAVKILP-EQGLMLTGS 170
C S + +G DT +V+ +D+ + GHTA V+ VK P +G++ +GS
Sbjct: 503 CDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGS 562
Query: 171 ADKTVKLW--KAGRCERTFSGHEDCVRGLAILSETEFL--SCANDASIRRWQI-TGECLE 225
D TV++W C +GH VRGL +E +L S + D +I+ W G C++
Sbjct: 563 DDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTREGTCVD 622
Query: 226 VYYGHTNYIYSISVFPNCRDF--VTTAEDRSLRIW 258
Y H +Y ++ P+ R F + + D ++R+W
Sbjct: 623 TVYDHGADVYGLTCHPS-RPFTMASCSRDSTVRLW 656
Score = 48.1 bits (113), Expect = 3e-05
Identities = 33/101 (32%), Positives = 50/101 (49%), Gaps = 5/101 (4%)
Query: 83 GLIATGGNDHNICIFSLDSPMPLYILKGHKNTVCSL--SSGKFGTLLSGSWDTTAKVW-- 138
G++ +G +D + I+ + IL GH V L ++ L+SGSWD T KVW
Sbjct: 556 GILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDT 615
Query: 139 LNDKCMMTLQGHTAAVWAVKILPEQGL-MLTGSADKTVKLW 178
C+ T+ H A V+ + P + M + S D TV+LW
Sbjct: 616 REGTCVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLW 656
Score = 33.5 bits (75), Expect = 0.80
Identities = 48/199 (24%), Positives = 80/199 (40%), Gaps = 25/199 (12%)
Query: 129 GSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQ-GLMLTGSADKTVKLWKAGRCER 185
G +D AK W L D GH ++ K P+ L+ T S D T+K+W
Sbjct: 351 GLYDMGAKKWDFLRDL------GHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLTA 404
Query: 186 TFS--GHEDCVRGLAILSETEFLSCANDASIRR----WQI-TGECLEVYYGH-TNYIYSI 237
++ G+E + L+ L+C + R W + G+ ++ + H TN I+ I
Sbjct: 405 VYTSPGNEGVIYSLSWAPGG--LNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCI 462
Query: 238 SVFPNCRDFVTTAEDRSLRIWK--HGECAQTIRLPAQSIWCCCVLDNGD-IVVGASDGII 294
+ + T I + G+ + PA C +N D I G D +
Sbjct: 463 AWSHKDSKRIATCSSDGFCIIRTIDGKVLHKYKHPAAVFGCDWSQNNKDMIATGCEDTNV 522
Query: 295 RVFTESEDRTASAEEIKAF 313
RV+ + T+S + +K F
Sbjct: 523 RVYYVA---TSSDQPLKVF 538
Score = 32.0 bits (71), Expect = 2.3
Identities = 15/31 (48%), Positives = 16/31 (51%)
Query: 17 HELDVRGLVCCAYPPGAFVSVSRDRTTRLWA 47
H DV GL C P S SRD T RLW+
Sbjct: 627 HGADVYGLTCHPSRPFTMASCSRDSTVRLWS 657
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,378,797
Number of Sequences: 37866
Number of extensions: 1448143
Number of successful extensions: 5124
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 118
Number of HSP's successfully gapped in prelim test: 140
Number of HSP's that attempted gapping in prelim test: 3633
Number of HSP's gapped (non-prelim): 857
length of query: 795
length of database: 18,247,518
effective HSP length: 110
effective length of query: 685
effective length of database: 14,082,258
effective search space: 9646346730
effective search space used: 9646346730
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.