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Search of human proteins with 6912338
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|6912338 dynein, axonemal, intermediate chain 1 [Homo
sapiens]
(699 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|6912338 dynein, axonemal, intermediate chain 1 [Homo sapiens] 1426 0.0
gi|46276887 WD repeat domain 78 isoform 1 [Homo sapiens] 236 5e-62
gi|217416452 dynein, axonemal, intermediate polypeptide 2 [Homo ... 128 2e-29
gi|24307879 dynein, cytoplasmic 1, intermediate chain 2 [Homo sa... 108 2e-23
gi|4758178 dynein, cytoplasmic 1, intermediate chain 1 isoform a... 104 3e-22
gi|207113122 dynein, cytoplasmic 1, intermediate chain 1 isoform... 104 3e-22
gi|207113124 dynein, cytoplasmic 1, intermediate chain 1 isoform... 103 7e-22
gi|66267730 WD repeat domain 34 [Homo sapiens] 89 2e-17
gi|46276885 WD repeat domain 78 isoform 2 [Homo sapiens] 69 2e-11
gi|19913367 transducin beta-like 1Y [Homo sapiens] 52 2e-06
gi|19913365 transducin beta-like 1Y [Homo sapiens] 52 2e-06
gi|15150805 transducin beta-like 1Y [Homo sapiens] 52 2e-06
gi|207029439 retinoblastoma binding protein 4 isoform c [Homo sa... 51 3e-06
gi|207029415 retinoblastoma binding protein 4 isoform b [Homo sa... 51 3e-06
gi|5032027 retinoblastoma binding protein 4 isoform a [Homo sapi... 51 3e-06
gi|4506439 retinoblastoma binding protein 7 [Homo sapiens] 51 4e-06
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 50 5e-06
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 50 5e-06
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 50 5e-06
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] 50 5e-06
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 49 2e-05
gi|26665869 WD repeat domain 51B [Homo sapiens] 47 6e-05
gi|4557467 excision repair cross-complementing rodent repair def... 46 1e-04
gi|229892270 WD repeats and SOF1 domain containing [Homo sapiens] 44 5e-04
gi|116256340 SEC31 homolog A isoform 3 [Homo sapiens] 44 7e-04
gi|116256338 SEC31 homolog A isoform 1 [Homo sapiens] 44 7e-04
gi|116256336 SEC31 homolog A isoform 4 [Homo sapiens] 44 7e-04
gi|41349441 SEC31 homolog A isoform 2 [Homo sapiens] 44 7e-04
gi|41349439 SEC31 homolog A isoform 1 [Homo sapiens] 44 7e-04
gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens] 42 0.001
>gi|6912338 dynein, axonemal, intermediate chain 1 [Homo sapiens]
Length = 699
Score = 1426 bits (3692), Expect = 0.0
Identities = 699/699 (100%), Positives = 699/699 (100%)
Query: 1 MIPASAKAPHKQPHKQSISIGRGTRKRDEDSGTEVGEGTDEWAQSKATVRPPDQLELTDA 60
MIPASAKAPHKQPHKQSISIGRGTRKRDEDSGTEVGEGTDEWAQSKATVRPPDQLELTDA
Sbjct: 1 MIPASAKAPHKQPHKQSISIGRGTRKRDEDSGTEVGEGTDEWAQSKATVRPPDQLELTDA 60
Query: 61 ELKEEFTRILTANNPHAPQNIVRYSFKEGTYKPIGFVNQLAVHYTQVGNLIPKDSDEGRR 120
ELKEEFTRILTANNPHAPQNIVRYSFKEGTYKPIGFVNQLAVHYTQVGNLIPKDSDEGRR
Sbjct: 61 ELKEEFTRILTANNPHAPQNIVRYSFKEGTYKPIGFVNQLAVHYTQVGNLIPKDSDEGRR 120
Query: 121 QHYRDELVAGSQESVKVISETGNLEEDEEPKELETEPGSQTDVPAAGAAEKVTEEELMTP 180
QHYRDELVAGSQESVKVISETGNLEEDEEPKELETEPGSQTDVPAAGAAEKVTEEELMTP
Sbjct: 121 QHYRDELVAGSQESVKVISETGNLEEDEEPKELETEPGSQTDVPAAGAAEKVTEEELMTP 180
Query: 181 KQPKERKLTNQFNFSERASQTYNNPVRDRECQTEPPPRTNFSATANQWEIYDAYVEELEK 240
KQPKERKLTNQFNFSERASQTYNNPVRDRECQTEPPPRTNFSATANQWEIYDAYVEELEK
Sbjct: 181 KQPKERKLTNQFNFSERASQTYNNPVRDRECQTEPPPRTNFSATANQWEIYDAYVEELEK 240
Query: 241 QEKTKEKEKAKTPVAKKSGKMAMRKLTSMESQTDDLIKLSQAAKIMERMVNQNTYDDIAQ 300
QEKTKEKEKAKTPVAKKSGKMAMRKLTSMESQTDDLIKLSQAAKIMERMVNQNTYDDIAQ
Sbjct: 241 QEKTKEKEKAKTPVAKKSGKMAMRKLTSMESQTDDLIKLSQAAKIMERMVNQNTYDDIAQ 300
Query: 301 DFKYYDDAADEYRDQVGTLLPLWKFQNDKAKRLSVTALCWNPKYRDLFAVGYGSYDFMKQ 360
DFKYYDDAADEYRDQVGTLLPLWKFQNDKAKRLSVTALCWNPKYRDLFAVGYGSYDFMKQ
Sbjct: 301 DFKYYDDAADEYRDQVGTLLPLWKFQNDKAKRLSVTALCWNPKYRDLFAVGYGSYDFMKQ 360
Query: 361 SRGMLLLYSLKNPSFPEYMFSSNSGVMCLDIHVDHPYLVAVGHYDGNVAIYNLKKPHSQP 420
SRGMLLLYSLKNPSFPEYMFSSNSGVMCLDIHVDHPYLVAVGHYDGNVAIYNLKKPHSQP
Sbjct: 361 SRGMLLLYSLKNPSFPEYMFSSNSGVMCLDIHVDHPYLVAVGHYDGNVAIYNLKKPHSQP 420
Query: 421 SFCSSAKSGKHSDPVWQVKWQKDDMDQNLNFFSVSSDGRIVSWTLVKRKLVHIDVIKLKV 480
SFCSSAKSGKHSDPVWQVKWQKDDMDQNLNFFSVSSDGRIVSWTLVKRKLVHIDVIKLKV
Sbjct: 421 SFCSSAKSGKHSDPVWQVKWQKDDMDQNLNFFSVSSDGRIVSWTLVKRKLVHIDVIKLKV 480
Query: 481 EGSTTEVPEGLQLHPVGCGTAFDFHKEIDYMFLVGTEEGKIYKCSKSYSSQFLDTYDAHN 540
EGSTTEVPEGLQLHPVGCGTAFDFHKEIDYMFLVGTEEGKIYKCSKSYSSQFLDTYDAHN
Sbjct: 481 EGSTTEVPEGLQLHPVGCGTAFDFHKEIDYMFLVGTEEGKIYKCSKSYSSQFLDTYDAHN 540
Query: 541 MSVDTVSWNPYHTKVFMSCSSDWTVKIWDHTIKTPMFIYDLNSAVGDVAWAPYSSTVFAA 600
MSVDTVSWNPYHTKVFMSCSSDWTVKIWDHTIKTPMFIYDLNSAVGDVAWAPYSSTVFAA
Sbjct: 541 MSVDTVSWNPYHTKVFMSCSSDWTVKIWDHTIKTPMFIYDLNSAVGDVAWAPYSSTVFAA 600
Query: 601 VTTDGKAHIFDLAINKYEAICNQPVAAKKNRLTHVQFNLIHPIIIVGDDRGHIISLKLSP 660
VTTDGKAHIFDLAINKYEAICNQPVAAKKNRLTHVQFNLIHPIIIVGDDRGHIISLKLSP
Sbjct: 601 VTTDGKAHIFDLAINKYEAICNQPVAAKKNRLTHVQFNLIHPIIIVGDDRGHIISLKLSP 660
Query: 661 NLRKMPKEKKGQEVQKGPAVEIAKLDKLLNLVREVKIKT 699
NLRKMPKEKKGQEVQKGPAVEIAKLDKLLNLVREVKIKT
Sbjct: 661 NLRKMPKEKKGQEVQKGPAVEIAKLDKLLNLVREVKIKT 699
>gi|46276887 WD repeat domain 78 isoform 1 [Homo sapiens]
Length = 848
Score = 236 bits (602), Expect = 5e-62
Identities = 172/603 (28%), Positives = 278/603 (46%), Gaps = 87/603 (14%)
Query: 143 NLEEDEEPKELETEPGSQTDVPAAGAAEKVTEEELMTPKQPK-----ERKLTNQFNFSER 197
+LE++ E ETE D+P + + E E +T + +L N + ER
Sbjct: 231 DLEKNIEIILTETETLRFFDLPTVMVSVESEEAEKVTQRNKNYEVLCRNRLGNDL-YVER 289
Query: 198 ASQTYNNPVRDRECQTEPPPRTNFSATANQWEIYDAY----VEELEKQEKTKEKEKAKTP 253
QT+N ++++ Q + + + W++YD+Y + L ++ E
Sbjct: 290 MMQTFNGAPKNKDVQCDKIIMEDKGIMSTAWDLYDSYNAMELVSLSVKQSVVESSSKANV 349
Query: 254 VAKKSGKMAMRKLTSMESQTDDLIKLSQA--AKI-----------------------MER 288
+ K + T S+T L+ + AKI MER
Sbjct: 350 LPKDQDQRLPGSTTEKNSETSSLMDIENVILAKIHEDEEDHSDAILKSDKFHQDLFFMER 409
Query: 289 MVNQNTY---------------------DDIAQDFKYYD---DAADEYRDQV-------- 316
++ +N + +D+ + K+ + ++ E +++
Sbjct: 410 VLMENIFQPKLAAYRQLPVLKEPEPEEPEDVLESAKHEEVEEESKKEEEEEIHAEESTIP 469
Query: 317 GTLLPLWKFQNDKAKRLSVTALCWNPKYRDLFAVGYGSYDFMKQSRGMLLLYSLKNPSFP 376
L LW F D K L+V++L WN DL AVGYG + F +Q RG+ +S+KNP +P
Sbjct: 470 ANLERLWSFSCDLTKGLNVSSLAWNKTNPDLLAVGYGHFGFKEQKRGLACCWSIKNPMWP 529
Query: 377 EYMFSSNSGVMCLDIHVDHPYLVAVGHYDGNVAIYNLKKPHSQPSFCSSAKSGKHSDPVW 436
E ++ S GV +D + P L+AVG+++G +AIYN++ + P SS KH PVW
Sbjct: 530 ERIYQSPYGVTAVDFSIGAPNLLAVGYHNGTIAIYNVRSNSNVPVLDSSESPQKHLGPVW 589
Query: 437 QVKWQKDDMDQNLN-----FFSVSSDGRIVSWTLVKRKLVHIDVIKLK-------VEGST 484
Q++W + D + S+S+DGRI W ++++ L D+++LK +G
Sbjct: 590 QLQWIEQDRGTTGDGKREILVSISADGRISKW-VIRKGLDCYDLMRLKRTTAASNKKGGE 648
Query: 485 TEVPEGLQLHPVGCGTAFDFHKEIDYMFLVGTEEGKIYKCSKSYSSQFLDTYDAHNMSVD 544
E + + G F FH + ++L GTEEG I+KCS SY+ Q+LDTY H V
Sbjct: 649 KEKKDEALISRQAPGMCFAFHPKDTNIYLAGTEEGHIHKCSCSYNEQYLDTYRGHKGPVY 708
Query: 545 TVSWNPYHTKVFMSCSSDWTVKIW-DHTIKTPMFIYDLNSAVGDVAWAPYSSTVFAAVTT 603
V+WNP+ VF+SCS+DW V IW +K + Y S V DVAW+P SS +FAA
Sbjct: 709 KVTWNPFCHDVFLSCSADWGVIIWQQENVKPSLSFYPATSVVYDVAWSPKSSYIFAA-AN 767
Query: 604 DGKAHIFDLAINKYEAICNQPVAAKKNRLTHVQFNLIHPIIIVGDDRGHIISLKLSPNLR 663
+ + I+DL I+ + + A + T + F ++VGD G + + LR
Sbjct: 768 ENRVEIWDLHISTLDPLIVN-TANPGIKFTTILFAKQTDCLLVGDSDGQVSVYE----LR 822
Query: 664 KMP 666
MP
Sbjct: 823 NMP 825
>gi|217416452 dynein, axonemal, intermediate polypeptide 2 [Homo
sapiens]
Length = 605
Score = 128 bits (321), Expect = 2e-29
Identities = 116/505 (22%), Positives = 216/505 (42%), Gaps = 39/505 (7%)
Query: 184 KERKLTNQFNFSERASQT----YNNPVRDRECQTEPPPRTNFSATANQWEIYDAYVEELE 239
K + Q NFS+R ++ NP + P T + + E ++A E E
Sbjct: 10 KRSEFGKQCNFSDRQAELNIDIMPNPELAEQFVERNPVDTGIQCSISMSE-HEANSERFE 68
Query: 240 KQEKTKEKEKAKTP--VAKKSGKMAMRKLTSMESQTDDLIKLSQAAKIMERMVNQNTYDD 297
+ + + P V + +R +E + + + Q IME + QN D
Sbjct: 69 METRGVNHVEGGWPKDVNPLELEQTIRFRKKVEKDENYVNAIMQLGSIMEHCIKQNNAID 128
Query: 298 IAQDFKYYDDAADEYRDQVGTLLPLWKFQNDKAKRLSVTALCWNPKYRDLFAVGYGSYDF 357
I +++ + D+ A E ++ + + F++ + + + T L W+P AV Y DF
Sbjct: 129 IYEEY-FNDEEAMEVMEEDPSAKTINVFRDPQEIKRAATHLSWHPDGNRKLAVAYSCLDF 187
Query: 358 MKQSRGML---LLYSLKNPSFPEYMFSSNSGVMCLDIHVDHPYLVAVGHYDGNVAIYNLK 414
+ GM ++ L+NP+ PE +S ++ L+ + +++ G Y+G +A ++ +
Sbjct: 188 QRAPVGMSSDSYIWDLENPNKPELALKPSSPLVTLEFNPKDSHVLLGGCYNGQIACWDTR 247
Query: 415 KPHSQPSFCSSAKSGKHSDPVWQVKWQKDDMDQNLNFFSVSSDGRIVSWTLVK----RKL 470
K S H DPV+ W + FS S+DG+++ W + K ++
Sbjct: 248 KGSLVAEL--STIESSHRDPVYGTIWLQS--KTGTECFSASTDGQVMWWDIRKMSEPTEV 303
Query: 471 VHIDVIKLKVEGSTTEVPEGLQLHPVGCGTAFDFHKEIDYMFLVGTEEGKIYKC---SKS 527
V +D+ K + QL + +F + F+VGTE+G + C +K+
Sbjct: 304 VILDITKKE------------QLENALGAISLEFESTLPTKFMVGTEQGIVISCNRKAKT 351
Query: 528 YSSQFLDTYDAHNMSVDTVSWNPYHTKVFMSCSSDWTVKIW--DHTIKTPMFIYDLNSAV 585
+ + + T+ H+ + + NP++ K F++ DWT +IW D + M+ + +
Sbjct: 352 SAEKIVCTFPGHHGPIYALQRNPFYPKNFLTV-GDWTARIWSEDSRESSIMWTKYHMAYL 410
Query: 586 GDVAWAPYSSTVFAAVTTDGKAHIFDLAINKYEAICNQPVAAKKNRLTHVQFNLIHPIII 645
D AW+P TVF DG I+D + + + V + VQ N +I
Sbjct: 411 TDAAWSPVRPTVFFTTRMDGTLDIWDFMFEQCDPTLSLKVCDEALFCLRVQDN--GCLIA 468
Query: 646 VGDDRGHIISLKLSPNLRKMPKEKK 670
G G L++SP L + + +K
Sbjct: 469 CGSQLGTTTLLEVSPGLSTLQRNEK 493
>gi|24307879 dynein, cytoplasmic 1, intermediate chain 2 [Homo
sapiens]
Length = 638
Score = 108 bits (270), Expect = 2e-23
Identities = 110/430 (25%), Positives = 187/430 (43%), Gaps = 34/430 (7%)
Query: 237 ELEKQEKTKEKEKAKTPVAKKSGKMAMRKLTSMESQTDDLIKLSQAAKIMERMVNQNTYD 296
E EK K E+ +K P + + + + L S E L + +I+ER +++
Sbjct: 188 EEEKTLKKDEENDSKAPPHELTEEEKQQILHSEEF----LSFFDHSTRIVERALSEQI-- 241
Query: 297 DIAQDFKYYDDAADEYRDQVGTLLPLWK--FQNDKAKRLSVTALCWNPKYRDLFAVGYGS 354
+I D+ D E Q G L L + F +K V+ L W+ +Y +L Y +
Sbjct: 242 NIFFDYSGRDLEDKEGEIQAGAKLSLNRQFFDERWSKHRVVSCLDWSSQYPELLVASYNN 301
Query: 355 Y-DFMKQSRGMLLLYSLK-NPSFPEYMFSSNSGVMCLDIHVDHPYLVAVGHYDGNVAIYN 412
D + G+ L++++K + PEY+F S VM HP LV G Y G + +++
Sbjct: 302 NEDAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSATFAKFHPNLVVGGTYSGQIVLWD 361
Query: 413 LKKPHSQPSFCSSAKSGKHSDPVWQVKWQKDDMDQNLNFFSVSSDGRIVSWTLVKRKLVH 472
+ P + + H+ PV+ V NL S+S+DG+I SW+L L H
Sbjct: 362 NRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNL--ISISTDGKICSWSL--DMLSH 417
Query: 473 IDVIKLKVEGSTTEVPEGLQLHPVGCGTAFDFHKEIDYMFLVGTEEGKIY-KCSKSYSSQ 531
V + V PVG D + F+VG+EEG +Y C +
Sbjct: 418 PQDSMELVHKQSKAVAVTSMSFPVG-----DVNN-----FVVGSEEGSVYTACRHGSKAG 467
Query: 532 FLDTYDAHNMSVDTVSWNPY-----HTKVFMSCSSDWTVKIWDHTIKTPMFIYDLNS-AV 585
+ ++ H + + + + +F++ S DWTVK+W P++ ++ N+ V
Sbjct: 468 ISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWTTKNNKPLYSFEDNADYV 527
Query: 586 GDVAWAPYSSTVFAAVTTDGKAHIFDLAINKYEAICNQPVAAKKN-RLTHVQFNLIHPII 644
DV W+P +FA V G+ +++L N + ++ + N L V++ I
Sbjct: 528 YDVMWSPTHPALFACVDGMGRLDLWNL--NNDTEVPTASISVEGNPALNRVRWTHSGREI 585
Query: 645 IVGDDRGHII 654
VGD G I+
Sbjct: 586 AVGDSEGQIV 595
>gi|4758178 dynein, cytoplasmic 1, intermediate chain 1 isoform a
[Homo sapiens]
Length = 645
Score = 104 bits (259), Expect = 3e-22
Identities = 130/545 (23%), Positives = 230/545 (42%), Gaps = 71/545 (13%)
Query: 129 AGSQESVKVISETGNLEEDEEPKELETEPGSQTDVPAAGAAEKVTEEELMTPKQPKERKL 188
AGSQ+S + T L+ D +P L+ Q+D K+ ++
Sbjct: 109 AGSQDSGDLGPLTRTLQWDTDPSVLQL----QSDSELGRRLHKLGVSKV----------- 153
Query: 189 TNQFNFSERASQTYNNPVRDRECQTEPPPRTNFSATANQ-WEIYDAYV---EELEKQEKT 244
Q +F R +Y+ +T+ P T+ S + E+ ++ V ELE Q+K
Sbjct: 154 -TQVDFLPREVVSYSK-------ETQTPLATHQSEEDEEDEEMVESKVGQDSELENQDKK 205
Query: 245 KEKEKAKTPVAKKSGKMAMRKLTSMESQT-----DDLIKLSQAAKIMERMVNQNTYDDIA 299
+E ++A R+LT E Q + LI + +++ER + +++ DI
Sbjct: 206 QEVKEAPP-----------RELTEEEKQQILHSEEFLIFFDRTIRVIERALAEDS--DIF 252
Query: 300 QDFKYYDDAADEYRDQVGTLLPLWKFQNDK--AKRLSVTALCWNPKYRDLFAVGYGSY-D 356
D+ + + Q G L + D+ +K VT + W+ +Y +L Y + D
Sbjct: 253 FDYSGRELEEKDGDVQAGANLSFNRQFYDEHWSKHRVVTCMDWSLQYPELMVASYNNNED 312
Query: 357 FMKQSRGMLLLYSLK-NPSFPEYMFSSNSGVMCLDIHVDHPYLVAVGHYDGNVAIYNLKK 415
+ G+ L++++K + PEY+F S VM + HP LV G Y G + +++ +
Sbjct: 313 APHEPDGVALVWNMKFKKTTPEYVFHCQSSVMSVCFARFHPNLVVGGTYSGQIVLWDNRS 372
Query: 416 PHSQPSFCSSAKSGKHSDPVWQVKWQKDDMDQNLNFFSVSSDGRIVSWTLVKRKLVHIDV 475
P + + H+ PV+ V NL +VS+DG++ SW+L D+
Sbjct: 373 HRRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNL--ITVSTDGKMCSWSL--------DM 422
Query: 476 IKLKVEGSTTEVPEGLQLHPVGCGTAFDFHKEIDYMFLVGTEEGKIY-KCSKSYSSQFLD 534
+ E + PV T F F+VG+EEG +Y C + +
Sbjct: 423 LSTPQESMELVYNKS---KPVAV-TGMAFPTGDVNNFVVGSEEGTVYTACRHGSKAGIGE 478
Query: 535 TYDAHNMSVDTVSWNPY-----HTKVFMSCSSDWTVKIWDHTIKTPMFIYDLNS-AVGDV 588
++ H V ++ + + +F++ S DWTVK+W P++ ++ N+ V DV
Sbjct: 479 VFEGHQGPVTGINCHMAVGPIDFSHLFVTSSFDWTVKLWTTKHNKPLYSFEDNADYVYDV 538
Query: 589 AWAPYSSTVFAAVTTDGKAHIFDLAINKYEAICNQPVAAKKNRLTHVQFNLIHPIIIVGD 648
W+P +FA V G+ +++L N E + L V++ + VGD
Sbjct: 539 MWSPVHPALFACVDGMGRLDLWNLN-NDTEVPTASVAIEGASALNRVRWAQAGKEVAVGD 597
Query: 649 DRGHI 653
G I
Sbjct: 598 SEGRI 602
>gi|207113122 dynein, cytoplasmic 1, intermediate chain 1 isoform b
[Homo sapiens]
Length = 628
Score = 104 bits (259), Expect = 3e-22
Identities = 130/545 (23%), Positives = 230/545 (42%), Gaps = 71/545 (13%)
Query: 129 AGSQESVKVISETGNLEEDEEPKELETEPGSQTDVPAAGAAEKVTEEELMTPKQPKERKL 188
AGSQ+S + T L+ D +P L+ Q+D K+ ++
Sbjct: 92 AGSQDSGDLGPLTRTLQWDTDPSVLQL----QSDSELGRRLHKLGVSKV----------- 136
Query: 189 TNQFNFSERASQTYNNPVRDRECQTEPPPRTNFSATANQ-WEIYDAYV---EELEKQEKT 244
Q +F R +Y+ +T+ P T+ S + E+ ++ V ELE Q+K
Sbjct: 137 -TQVDFLPREVVSYSK-------ETQTPLATHQSEEDEEDEEMVESKVGQDSELENQDKK 188
Query: 245 KEKEKAKTPVAKKSGKMAMRKLTSMESQT-----DDLIKLSQAAKIMERMVNQNTYDDIA 299
+E ++A R+LT E Q + LI + +++ER + +++ DI
Sbjct: 189 QEVKEAPP-----------RELTEEEKQQILHSEEFLIFFDRTIRVIERALAEDS--DIF 235
Query: 300 QDFKYYDDAADEYRDQVGTLLPLWKFQNDK--AKRLSVTALCWNPKYRDLFAVGYGSY-D 356
D+ + + Q G L + D+ +K VT + W+ +Y +L Y + D
Sbjct: 236 FDYSGRELEEKDGDVQAGANLSFNRQFYDEHWSKHRVVTCMDWSLQYPELMVASYNNNED 295
Query: 357 FMKQSRGMLLLYSLK-NPSFPEYMFSSNSGVMCLDIHVDHPYLVAVGHYDGNVAIYNLKK 415
+ G+ L++++K + PEY+F S VM + HP LV G Y G + +++ +
Sbjct: 296 APHEPDGVALVWNMKFKKTTPEYVFHCQSSVMSVCFARFHPNLVVGGTYSGQIVLWDNRS 355
Query: 416 PHSQPSFCSSAKSGKHSDPVWQVKWQKDDMDQNLNFFSVSSDGRIVSWTLVKRKLVHIDV 475
P + + H+ PV+ V NL +VS+DG++ SW+L D+
Sbjct: 356 HRRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNL--ITVSTDGKMCSWSL--------DM 405
Query: 476 IKLKVEGSTTEVPEGLQLHPVGCGTAFDFHKEIDYMFLVGTEEGKIY-KCSKSYSSQFLD 534
+ E + PV T F F+VG+EEG +Y C + +
Sbjct: 406 LSTPQESMELVYNKS---KPVAV-TGMAFPTGDVNNFVVGSEEGTVYTACRHGSKAGIGE 461
Query: 535 TYDAHNMSVDTVSWNPY-----HTKVFMSCSSDWTVKIWDHTIKTPMFIYDLNS-AVGDV 588
++ H V ++ + + +F++ S DWTVK+W P++ ++ N+ V DV
Sbjct: 462 VFEGHQGPVTGINCHMAVGPIDFSHLFVTSSFDWTVKLWTTKHNKPLYSFEDNADYVYDV 521
Query: 589 AWAPYSSTVFAAVTTDGKAHIFDLAINKYEAICNQPVAAKKNRLTHVQFNLIHPIIIVGD 648
W+P +FA V G+ +++L N E + L V++ + VGD
Sbjct: 522 MWSPVHPALFACVDGMGRLDLWNLN-NDTEVPTASVAIEGASALNRVRWAQAGKEVAVGD 580
Query: 649 DRGHI 653
G I
Sbjct: 581 SEGRI 585
>gi|207113124 dynein, cytoplasmic 1, intermediate chain 1 isoform c
[Homo sapiens]
Length = 608
Score = 103 bits (256), Expect = 7e-22
Identities = 107/433 (24%), Positives = 188/433 (43%), Gaps = 44/433 (10%)
Query: 237 ELEKQEKTKEKEKAKTPVAKKSGKMAMRKLTSMESQT-----DDLIKLSQAAKIMERMVN 291
ELE Q+K +E ++A R+LT E Q + LI + +++ER +
Sbjct: 161 ELENQDKKQEVKEAPP-----------RELTEEEKQQILHSEEFLIFFDRTIRVIERALA 209
Query: 292 QNTYDDIAQDFKYYDDAADEYRDQVGTLLPLWKFQNDK--AKRLSVTALCWNPKYRDLFA 349
+++ DI D+ + + Q G L + D+ +K VT + W+ +Y +L
Sbjct: 210 EDS--DIFFDYSGRELEEKDGDVQAGANLSFNRQFYDEHWSKHRVVTCMDWSLQYPELMV 267
Query: 350 VGYGSY-DFMKQSRGMLLLYSLK-NPSFPEYMFSSNSGVMCLDIHVDHPYLVAVGHYDGN 407
Y + D + G+ L++++K + PEY+F S VM + HP LV G Y G
Sbjct: 268 ASYNNNEDAPHEPDGVALVWNMKFKKTTPEYVFHCQSSVMSVCFARFHPNLVVGGTYSGQ 327
Query: 408 VAIYNLKKPHSQPSFCSSAKSGKHSDPVWQVKWQKDDMDQNLNFFSVSSDGRIVSWTLVK 467
+ +++ + P + + H+ PV+ V NL +VS+DG++ SW+L
Sbjct: 328 IVLWDNRSHRRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNL--ITVSTDGKMCSWSL-- 383
Query: 468 RKLVHIDVIKLKVEGSTTEVPEGLQLHPVGCGTAFDFHKEIDYMFLVGTEEGKIY-KCSK 526
D++ E + PV T F F+VG+EEG +Y C
Sbjct: 384 ------DMLSTPQESMELVYNKS---KPVAV-TGMAFPTGDVNNFVVGSEEGTVYTACRH 433
Query: 527 SYSSQFLDTYDAHNMSVDTVSWNPY-----HTKVFMSCSSDWTVKIWDHTIKTPMFIYDL 581
+ + ++ H V ++ + + +F++ S DWTVK+W P++ ++
Sbjct: 434 GSKAGIGEVFEGHQGPVTGINCHMAVGPIDFSHLFVTSSFDWTVKLWTTKHNKPLYSFED 493
Query: 582 NS-AVGDVAWAPYSSTVFAAVTTDGKAHIFDLAINKYEAICNQPVAAKKNRLTHVQFNLI 640
N+ V DV W+P +FA V G+ +++L N E + L V++
Sbjct: 494 NADYVYDVMWSPVHPALFACVDGMGRLDLWNLN-NDTEVPTASVAIEGASALNRVRWAQA 552
Query: 641 HPIIIVGDDRGHI 653
+ VGD G I
Sbjct: 553 GKEVAVGDSEGRI 565
>gi|66267730 WD repeat domain 34 [Homo sapiens]
Length = 536
Score = 88.6 bits (218), Expect = 2e-17
Identities = 82/315 (26%), Positives = 134/315 (42%), Gaps = 38/315 (12%)
Query: 329 KAKRLSVTALCWNPKYRDLFAVGYGSYDFMKQS--RGMLLLYSLKN----PSFPEYMFSS 382
+A+ L VT++ WN + A YG D S + + ++L P P +
Sbjct: 158 QAQGLHVTSISWNST-GSVVACAYGRLDHGDWSTLKSFVCAWNLDRRDLRPQQPSAVVEV 216
Query: 383 NSGVMCLDIHVDHPYLVAVGHYDGNVAIYNLKKPHSQPSFCSSAKSGKHSDPVWQVKW-Q 441
S V+CL H P VA G Y G V +++L + + + H+DPV QV W
Sbjct: 217 PSAVLCLAFHPTQPSHVAGGLYSGEVLVWDLSRLEDPLLWRTGLTDDTHTDPVSQVVWLP 276
Query: 442 KDDMDQNLNFFSVSSDGRIVSWTLVKRKLVHIDVIKLKVEGST---TEVPEGLQL--HPV 496
+ SV++DG+++ W + + + ++L EG ++P +L HP
Sbjct: 277 EPGHSHRFQVLSVATDGKVLLW-----QGIGVGQLQL-TEGFALVMQQLPRSTKLKKHPR 330
Query: 497 G----CGTAFDFHKEIDYMFLVGTEEGKIYKCSKSYSSQFLD--------------TYDA 538
G TA F +F++GTE G KCS + L T+
Sbjct: 331 GETEVGATAVAFSSFDPRLFILGTEGGFPLKCSLAAGEAALTRMPSSVPLRAPAQFTFSP 390
Query: 539 HNMSVDTVSWNPYHTKVFMSCSSDWTVKIWDHTIKTPMFIYDLN-SAVGDVAWAPYSSTV 597
H + +VS +P+H +F+S +D V ++ P+ L+ + V W+P V
Sbjct: 391 HGGPIYSVSCSPFHRNLFLSAGTDGHVHLYSMLQAPPLTSLQLSLKYLFAVRWSPVRPLV 450
Query: 598 FAAVTTDGKAHIFDL 612
FAA + G +FDL
Sbjct: 451 FAAASGKGDVQLFDL 465
>gi|46276885 WD repeat domain 78 isoform 2 [Homo sapiens]
Length = 545
Score = 68.6 bits (166), Expect = 2e-11
Identities = 66/297 (22%), Positives = 117/297 (39%), Gaps = 67/297 (22%)
Query: 143 NLEEDEEPKELETEPGSQTDVPAAGAAEKVTEEELMTPKQPK-----ERKLTNQFNFSER 197
+LE++ E ETE D+P + + E E +T + +L N + ER
Sbjct: 231 DLEKNIEIILTETETLRFFDLPTVMVSVESEEAEKVTQRNKNYEVLCRNRLGNDL-YVER 289
Query: 198 ASQTYNNPVRDRECQTEPPPRTNFSATANQWEIYDAY----VEELEKQEKTKEKEKAKTP 253
QT+N ++++ Q + + + W++YD+Y + L ++ E
Sbjct: 290 MMQTFNGAPKNKDVQCDKIIMEDKGIMSTAWDLYDSYNAMELVSLSVKQSVVESSSKANV 349
Query: 254 VAKKSGKMAMRKLTSMESQTDDLIKLSQA--AKI-----------------------MER 288
+ K + T S+T L+ + AKI MER
Sbjct: 350 LPKDQDQRLPGSTTEKNSETSSLMDIENVILAKIHEDEEDHSDAILKSDKFHQDLFFMER 409
Query: 289 MVNQNTY---------------------DDIAQDFKYYD---DAADEYRDQV-------- 316
++ +N + +D+ + K+ + ++ E +++
Sbjct: 410 VLMENIFQPKLAAYRQLPVLKEPEPEEPEDVLESAKHEEVEEESKKEEEEEIHAEESTIP 469
Query: 317 GTLLPLWKFQNDKAKRLSVTALCWNPKYRDLFAVGYGSYDFMKQSRGMLLLYSLKNP 373
L LW F D K L+V++L WN DL AVGYG + F +Q RG+ +S+KNP
Sbjct: 470 ANLERLWSFSCDLTKGLNVSSLAWNKTNPDLLAVGYGHFGFKEQKRGLACCWSIKNP 526
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 51.6 bits (122), Expect = 2e-06
Identities = 69/319 (21%), Positives = 118/319 (36%), Gaps = 64/319 (20%)
Query: 340 WNPKYRDLFAVGYGS-----YDFMKQSRG----MLLLYSLKNPSFPEYMFSSNSGVMCLD 390
WNP DL A G G ++ + S G ++L + ++ + SN V LD
Sbjct: 187 WNP-VSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG---HDVPSNKDVTSLD 242
Query: 391 IHVDHPYLVAVGHYDGNVAIYNLKKPHSQPSFCSSAKSGKHSDPVWQVKWQKDDMDQNLN 450
+ D L+A+G YDG I+ + S+ G+H P++ +KW K +
Sbjct: 243 WNSDGT-LLAMGSYDGFARIWT-----ENGNLASTL--GQHKGPIFALKWNK----KGNY 290
Query: 451 FFSVSSDGRIVSWTLVKRKLVHIDVIKLKVEGSTTEVPEGLQLHPVGCGTAFDFHKEIDY 510
S D + W E Q P A D + +
Sbjct: 291 VLSAGVDKTTIIWD--------------------AHTGEAKQQFPFHSAPALDVDWQNNM 330
Query: 511 MFLVGTEEGKIYKCSKSYSSQFLDTYDAHNMSVDTVSWNPYHTKVFMSCSSDWTVKIWDH 570
F + + I+ C + T+ H V+ + W+P + SCS D T+KIW
Sbjct: 331 TFASCSTDMCIHVCRLGCDHP-VKTFQGHTNEVNAIKWDP-SGMLLASCSDDMTLKIW-- 386
Query: 571 TIKTPMFIYDLN-----------SAVGDVAWAPYSSTVFAAVTTDGKAHIFDLAINKYEA 619
++K ++DL S G P SS + A+ + D ++D+ +
Sbjct: 387 SMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVE----QG 442
Query: 620 ICNQPVAAKKNRLTHVQFN 638
+C + + + V F+
Sbjct: 443 VCTHTLMKHQEPVYSVAFS 461
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 51.6 bits (122), Expect = 2e-06
Identities = 69/319 (21%), Positives = 118/319 (36%), Gaps = 64/319 (20%)
Query: 340 WNPKYRDLFAVGYGS-----YDFMKQSRG----MLLLYSLKNPSFPEYMFSSNSGVMCLD 390
WNP DL A G G ++ + S G ++L + ++ + SN V LD
Sbjct: 187 WNP-VSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG---HDVPSNKDVTSLD 242
Query: 391 IHVDHPYLVAVGHYDGNVAIYNLKKPHSQPSFCSSAKSGKHSDPVWQVKWQKDDMDQNLN 450
+ D L+A+G YDG I+ + S+ G+H P++ +KW K +
Sbjct: 243 WNSDGT-LLAMGSYDGFARIWT-----ENGNLASTL--GQHKGPIFALKWNK----KGNY 290
Query: 451 FFSVSSDGRIVSWTLVKRKLVHIDVIKLKVEGSTTEVPEGLQLHPVGCGTAFDFHKEIDY 510
S D + W E Q P A D + +
Sbjct: 291 VLSAGVDKTTIIWD--------------------AHTGEAKQQFPFHSAPALDVDWQNNM 330
Query: 511 MFLVGTEEGKIYKCSKSYSSQFLDTYDAHNMSVDTVSWNPYHTKVFMSCSSDWTVKIWDH 570
F + + I+ C + T+ H V+ + W+P + SCS D T+KIW
Sbjct: 331 TFASCSTDMCIHVCRLGCDHP-VKTFQGHTNEVNAIKWDP-SGMLLASCSDDMTLKIW-- 386
Query: 571 TIKTPMFIYDLN-----------SAVGDVAWAPYSSTVFAAVTTDGKAHIFDLAINKYEA 619
++K ++DL S G P SS + A+ + D ++D+ +
Sbjct: 387 SMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVE----QG 442
Query: 620 ICNQPVAAKKNRLTHVQFN 638
+C + + + V F+
Sbjct: 443 VCTHTLMKHQEPVYSVAFS 461
>gi|15150805 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 51.6 bits (122), Expect = 2e-06
Identities = 69/319 (21%), Positives = 118/319 (36%), Gaps = 64/319 (20%)
Query: 340 WNPKYRDLFAVGYGS-----YDFMKQSRG----MLLLYSLKNPSFPEYMFSSNSGVMCLD 390
WNP DL A G G ++ + S G ++L + ++ + SN V LD
Sbjct: 187 WNP-VSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG---HDVPSNKDVTSLD 242
Query: 391 IHVDHPYLVAVGHYDGNVAIYNLKKPHSQPSFCSSAKSGKHSDPVWQVKWQKDDMDQNLN 450
+ D L+A+G YDG I+ + S+ G+H P++ +KW K +
Sbjct: 243 WNSDGT-LLAMGSYDGFARIWT-----ENGNLASTL--GQHKGPIFALKWNK----KGNY 290
Query: 451 FFSVSSDGRIVSWTLVKRKLVHIDVIKLKVEGSTTEVPEGLQLHPVGCGTAFDFHKEIDY 510
S D + W E Q P A D + +
Sbjct: 291 VLSAGVDKTTIIWD--------------------AHTGEAKQQFPFHSAPALDVDWQNNM 330
Query: 511 MFLVGTEEGKIYKCSKSYSSQFLDTYDAHNMSVDTVSWNPYHTKVFMSCSSDWTVKIWDH 570
F + + I+ C + T+ H V+ + W+P + SCS D T+KIW
Sbjct: 331 TFASCSTDMCIHVCRLGCDHP-VKTFQGHTNEVNAIKWDP-SGMLLASCSDDMTLKIW-- 386
Query: 571 TIKTPMFIYDLN-----------SAVGDVAWAPYSSTVFAAVTTDGKAHIFDLAINKYEA 619
++K ++DL S G P SS + A+ + D ++D+ +
Sbjct: 387 SMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVE----QG 442
Query: 620 ICNQPVAAKKNRLTHVQFN 638
+C + + + V F+
Sbjct: 443 VCTHTLMKHQEPVYSVAFS 461
>gi|207029439 retinoblastoma binding protein 4 isoform c [Homo
sapiens]
Length = 390
Score = 51.2 bits (121), Expect = 3e-06
Identities = 26/95 (27%), Positives = 54/95 (56%), Gaps = 2/95 (2%)
Query: 521 IYKCSKSYSSQFLDTYDAHNMSVDTVSWNPYHTKVFMSCSSDWTVKIWD-HTIKTPMFIY 579
I+ + +S+ + DAH V+ +S+NPY + + S+D TV +WD +K + +
Sbjct: 219 IWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSF 278
Query: 580 DLN-SAVGDVAWAPYSSTVFAAVTTDGKAHIFDLA 613
+ + + V W+P++ T+ A+ TD + +++DL+
Sbjct: 279 ESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLS 313
Score = 42.4 bits (98), Expect = 0.001
Identities = 33/147 (22%), Positives = 67/147 (45%), Gaps = 10/147 (6%)
Query: 536 YDAHNMSVDTVSWNPYHTKVFMSCSSDWTVKIWD---HTIKTPMFIYDLNSA-VGDVAWA 591
+ H V+ VSW+ H +F S + D + IWD + P D ++A V +++
Sbjct: 188 FTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFN 247
Query: 592 PYSSTVFAAVTTDGKAHIFDLAINKYEAICNQPVAAKKNRLTHVQFNLIHPIIIVGDDRG 651
PYS + A + D ++DL K + + K+ + VQ++ + I+
Sbjct: 248 PYSEFILATGSADKTVALWDLRNLKLKL---HSFESHKDEIFQVQWSPHNETILASSGTD 304
Query: 652 HIISLKLSPNLRKMPKEKKGQEVQKGP 678
+++ +L K+ +E+ ++ + GP
Sbjct: 305 RRLNVW---DLSKIGEEQSPEDAEDGP 328
Score = 35.8 bits (81), Expect = 0.14
Identities = 21/78 (26%), Positives = 33/78 (42%), Gaps = 8/78 (10%)
Query: 546 VSWNPYHTKVFMSCSSDWTVKIWD--------HTIKTPMFIYDLNSAVGDVAWAPYSSTV 597
+SWNP + +S S D T+ +WD + + V DV+W ++
Sbjct: 148 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESL 207
Query: 598 FAAVTTDGKAHIFDLAIN 615
F +V D K I+D N
Sbjct: 208 FGSVADDQKLMIWDTRSN 225
>gi|207029415 retinoblastoma binding protein 4 isoform b [Homo
sapiens]
Length = 424
Score = 51.2 bits (121), Expect = 3e-06
Identities = 26/95 (27%), Positives = 54/95 (56%), Gaps = 2/95 (2%)
Query: 521 IYKCSKSYSSQFLDTYDAHNMSVDTVSWNPYHTKVFMSCSSDWTVKIWD-HTIKTPMFIY 579
I+ + +S+ + DAH V+ +S+NPY + + S+D TV +WD +K + +
Sbjct: 253 IWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSF 312
Query: 580 DLN-SAVGDVAWAPYSSTVFAAVTTDGKAHIFDLA 613
+ + + V W+P++ T+ A+ TD + +++DL+
Sbjct: 313 ESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLS 347
Score = 42.4 bits (98), Expect = 0.001
Identities = 33/147 (22%), Positives = 67/147 (45%), Gaps = 10/147 (6%)
Query: 536 YDAHNMSVDTVSWNPYHTKVFMSCSSDWTVKIWD---HTIKTPMFIYDLNSA-VGDVAWA 591
+ H V+ VSW+ H +F S + D + IWD + P D ++A V +++
Sbjct: 222 FTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFN 281
Query: 592 PYSSTVFAAVTTDGKAHIFDLAINKYEAICNQPVAAKKNRLTHVQFNLIHPIIIVGDDRG 651
PYS + A + D ++DL K + + K+ + VQ++ + I+
Sbjct: 282 PYSEFILATGSADKTVALWDLRNLKLKL---HSFESHKDEIFQVQWSPHNETILASSGTD 338
Query: 652 HIISLKLSPNLRKMPKEKKGQEVQKGP 678
+++ +L K+ +E+ ++ + GP
Sbjct: 339 RRLNVW---DLSKIGEEQSPEDAEDGP 362
Score = 35.8 bits (81), Expect = 0.14
Identities = 21/78 (26%), Positives = 33/78 (42%), Gaps = 8/78 (10%)
Query: 546 VSWNPYHTKVFMSCSSDWTVKIWD--------HTIKTPMFIYDLNSAVGDVAWAPYSSTV 597
+SWNP + +S S D T+ +WD + + V DV+W ++
Sbjct: 182 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESL 241
Query: 598 FAAVTTDGKAHIFDLAIN 615
F +V D K I+D N
Sbjct: 242 FGSVADDQKLMIWDTRSN 259
>gi|5032027 retinoblastoma binding protein 4 isoform a [Homo
sapiens]
Length = 425
Score = 51.2 bits (121), Expect = 3e-06
Identities = 26/95 (27%), Positives = 54/95 (56%), Gaps = 2/95 (2%)
Query: 521 IYKCSKSYSSQFLDTYDAHNMSVDTVSWNPYHTKVFMSCSSDWTVKIWD-HTIKTPMFIY 579
I+ + +S+ + DAH V+ +S+NPY + + S+D TV +WD +K + +
Sbjct: 254 IWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSF 313
Query: 580 DLN-SAVGDVAWAPYSSTVFAAVTTDGKAHIFDLA 613
+ + + V W+P++ T+ A+ TD + +++DL+
Sbjct: 314 ESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLS 348
Score = 42.4 bits (98), Expect = 0.001
Identities = 33/147 (22%), Positives = 67/147 (45%), Gaps = 10/147 (6%)
Query: 536 YDAHNMSVDTVSWNPYHTKVFMSCSSDWTVKIWD---HTIKTPMFIYDLNSA-VGDVAWA 591
+ H V+ VSW+ H +F S + D + IWD + P D ++A V +++
Sbjct: 223 FTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFN 282
Query: 592 PYSSTVFAAVTTDGKAHIFDLAINKYEAICNQPVAAKKNRLTHVQFNLIHPIIIVGDDRG 651
PYS + A + D ++DL K + + K+ + VQ++ + I+
Sbjct: 283 PYSEFILATGSADKTVALWDLRNLKLKL---HSFESHKDEIFQVQWSPHNETILASSGTD 339
Query: 652 HIISLKLSPNLRKMPKEKKGQEVQKGP 678
+++ +L K+ +E+ ++ + GP
Sbjct: 340 RRLNVW---DLSKIGEEQSPEDAEDGP 363
Score = 35.8 bits (81), Expect = 0.14
Identities = 21/78 (26%), Positives = 33/78 (42%), Gaps = 8/78 (10%)
Query: 546 VSWNPYHTKVFMSCSSDWTVKIWD--------HTIKTPMFIYDLNSAVGDVAWAPYSSTV 597
+SWNP + +S S D T+ +WD + + V DV+W ++
Sbjct: 183 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESL 242
Query: 598 FAAVTTDGKAHIFDLAIN 615
F +V D K I+D N
Sbjct: 243 FGSVADDQKLMIWDTRSN 260
>gi|4506439 retinoblastoma binding protein 7 [Homo sapiens]
Length = 425
Score = 50.8 bits (120), Expect = 4e-06
Identities = 24/79 (30%), Positives = 47/79 (59%), Gaps = 2/79 (2%)
Query: 537 DAHNMSVDTVSWNPYHTKVFMSCSSDWTVKIWD-HTIKTPMFIYDLN-SAVGDVAWAPYS 594
DAH V+ +S+NPY + + S+D TV +WD +K + ++ + + V W+P++
Sbjct: 269 DAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHN 328
Query: 595 STVFAAVTTDGKAHIFDLA 613
T+ A+ TD + +++DL+
Sbjct: 329 ETILASSGTDRRLNVWDLS 347
Score = 46.2 bits (108), Expect = 1e-04
Identities = 40/183 (21%), Positives = 81/183 (44%), Gaps = 18/183 (9%)
Query: 500 TAFDFHKEIDYMFLVGTEEGKIYKCSKSYSSQFLDTYDAHNMSVDTVSWNPYHTKVFMSC 559
+A D H + G +EGKI ++ H+ V+ V+W+ H +F S
Sbjct: 194 SASDDHTVCLWDINAGPKEGKIVDAKAIFTG--------HSAVVEDVAWHLLHESLFGSV 245
Query: 560 SSDWTVKIWD---HTIKTPMFIYDLNSA-VGDVAWAPYSSTVFAAVTTDGKAHIFDLAIN 615
+ D + IWD +T P + D ++A V +++ PYS + A + D ++DL
Sbjct: 246 ADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL 305
Query: 616 KYEAICNQPVAAKKNRLTHVQFNLIHPIIIVGDDRGHIISLKLSPNLRKMPKEKKGQEVQ 675
K + + K+ + V ++ + I+ +++ +L K+ +E+ ++ +
Sbjct: 306 KLKL---HTFESHKDEIFQVHWSPHNETILASSGTDRRLNVW---DLSKIGEEQSAEDAE 359
Query: 676 KGP 678
GP
Sbjct: 360 DGP 362
Score = 40.0 bits (92), Expect = 0.007
Identities = 40/202 (19%), Positives = 77/202 (38%), Gaps = 33/202 (16%)
Query: 431 HSDPVWQVKWQKDDMDQNLNFFSVSSDGRIVSWTLVKRKLVHIDVIKLKVEGSTTEVPEG 490
HS V V W + ++L F SV+ D +++ W +TT P
Sbjct: 225 HSAVVEDVAWHL--LHESL-FGSVADDQKLMIWD---------------TRSNTTSKPSH 266
Query: 491 LQLHPVGCGTAFDFHKEIDYMFLVGTEEGKIYKCSKSYSSQFLDTYDAHNMSVDTVSWNP 550
L F+ +++ G+ + + L T+++H + V W+P
Sbjct: 267 LVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSP 326
Query: 551 YHTKVFMSCSSDWTVKIWDHT--------------IKTPMFIYDLNSA-VGDVAWAPYSS 595
++ + S +D + +WD + +FI+ ++A + D +W P
Sbjct: 327 HNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEP 386
Query: 596 TVFAAVTTDGKAHIFDLAINKY 617
V +V+ D I+ +A N Y
Sbjct: 387 WVICSVSEDNIMQIWQMAENIY 408
Score = 34.3 bits (77), Expect = 0.40
Identities = 22/78 (28%), Positives = 33/78 (42%), Gaps = 8/78 (10%)
Query: 546 VSWNPYHTKVFMSCSSDWTVKIWD--------HTIKTPMFIYDLNSAVGDVAWAPYSSTV 597
+SWN + +S S D TV +WD + ++ V DVAW ++
Sbjct: 182 LSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESL 241
Query: 598 FAAVTTDGKAHIFDLAIN 615
F +V D K I+D N
Sbjct: 242 FGSVADDQKLMIWDTRSN 259
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 50.4 bits (119), Expect = 5e-06
Identities = 67/319 (21%), Positives = 120/319 (37%), Gaps = 64/319 (20%)
Query: 340 WNPKYRDLFAVGYGS-----YDFMKQSRG----MLLLYSLKNPSFPEYMFSSNSGVMCLD 390
WNP DL A G G ++ + S G ++L + ++ + SN V LD
Sbjct: 189 WNP-VSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG---HDVPSNKDVTSLD 244
Query: 391 IHVDHPYLVAVGHYDGNVAIYNLKKPHSQPSFCSSAKSGKHSDPVWQVKWQKDDMDQNLN 450
+ + L+A G YDG I+ + S+ G+H P++ +KW + +
Sbjct: 245 WNTNGT-LLATGSYDGFARIWT-----EDGNLASTL--GQHKGPIFALKWNR----KGNY 292
Query: 451 FFSVSSDGRIVSWTLVKRKLVHIDVIKLKVEGSTTEVPEGLQLHPVGCGTAFDFHKEIDY 510
S D + W E Q P A D + +
Sbjct: 293 ILSAGVDKTTIIWD--------------------AHTGEAKQQFPFHSAPALDVDWQNNT 332
Query: 511 MFLVGTEEGKIYKCSKSYSSQFLDTYDAHNMSVDTVSWNPYHTKVFMSCSSDWTVKIWDH 570
F + + I+ C + T+ H V+ + W+P + SCS D T+KIW
Sbjct: 333 TFASCSTDMCIHVCRLGCDRP-VKTFQGHTNEVNAIKWDP-SGMLLASCSDDMTLKIW-- 388
Query: 571 TIKTPMFIYDL---NSAVGDVAWA--------PYSSTVFAAVTTDGKAHIFDLAINKYEA 619
++K + I+DL N + + W+ P S+ + A+ + D ++D+
Sbjct: 389 SMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIE----RG 444
Query: 620 ICNQPVAAKKNRLTHVQFN 638
+C + + + V F+
Sbjct: 445 VCTHTLTKHQEPVYSVAFS 463
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 50.4 bits (119), Expect = 5e-06
Identities = 67/319 (21%), Positives = 120/319 (37%), Gaps = 64/319 (20%)
Query: 340 WNPKYRDLFAVGYGS-----YDFMKQSRG----MLLLYSLKNPSFPEYMFSSNSGVMCLD 390
WNP DL A G G ++ + S G ++L + ++ + SN V LD
Sbjct: 189 WNP-VSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG---HDVPSNKDVTSLD 244
Query: 391 IHVDHPYLVAVGHYDGNVAIYNLKKPHSQPSFCSSAKSGKHSDPVWQVKWQKDDMDQNLN 450
+ + L+A G YDG I+ + S+ G+H P++ +KW + +
Sbjct: 245 WNTNGT-LLATGSYDGFARIWT-----EDGNLASTL--GQHKGPIFALKWNR----KGNY 292
Query: 451 FFSVSSDGRIVSWTLVKRKLVHIDVIKLKVEGSTTEVPEGLQLHPVGCGTAFDFHKEIDY 510
S D + W E Q P A D + +
Sbjct: 293 ILSAGVDKTTIIWD--------------------AHTGEAKQQFPFHSAPALDVDWQNNT 332
Query: 511 MFLVGTEEGKIYKCSKSYSSQFLDTYDAHNMSVDTVSWNPYHTKVFMSCSSDWTVKIWDH 570
F + + I+ C + T+ H V+ + W+P + SCS D T+KIW
Sbjct: 333 TFASCSTDMCIHVCRLGCDRP-VKTFQGHTNEVNAIKWDP-SGMLLASCSDDMTLKIW-- 388
Query: 571 TIKTPMFIYDL---NSAVGDVAWA--------PYSSTVFAAVTTDGKAHIFDLAINKYEA 619
++K + I+DL N + + W+ P S+ + A+ + D ++D+
Sbjct: 389 SMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIE----RG 444
Query: 620 ICNQPVAAKKNRLTHVQFN 638
+C + + + V F+
Sbjct: 445 VCTHTLTKHQEPVYSVAFS 463
>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 50.4 bits (119), Expect = 5e-06
Identities = 67/319 (21%), Positives = 120/319 (37%), Gaps = 64/319 (20%)
Query: 340 WNPKYRDLFAVGYGS-----YDFMKQSRG----MLLLYSLKNPSFPEYMFSSNSGVMCLD 390
WNP DL A G G ++ + S G ++L + ++ + SN V LD
Sbjct: 240 WNP-VSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG---HDVPSNKDVTSLD 295
Query: 391 IHVDHPYLVAVGHYDGNVAIYNLKKPHSQPSFCSSAKSGKHSDPVWQVKWQKDDMDQNLN 450
+ + L+A G YDG I+ + S+ G+H P++ +KW + +
Sbjct: 296 WNTNGT-LLATGSYDGFARIWT-----EDGNLASTL--GQHKGPIFALKWNR----KGNY 343
Query: 451 FFSVSSDGRIVSWTLVKRKLVHIDVIKLKVEGSTTEVPEGLQLHPVGCGTAFDFHKEIDY 510
S D + W E Q P A D + +
Sbjct: 344 ILSAGVDKTTIIWD--------------------AHTGEAKQQFPFHSAPALDVDWQNNT 383
Query: 511 MFLVGTEEGKIYKCSKSYSSQFLDTYDAHNMSVDTVSWNPYHTKVFMSCSSDWTVKIWDH 570
F + + I+ C + T+ H V+ + W+P + SCS D T+KIW
Sbjct: 384 TFASCSTDMCIHVCRLGCDRP-VKTFQGHTNEVNAIKWDP-SGMLLASCSDDMTLKIW-- 439
Query: 571 TIKTPMFIYDL---NSAVGDVAWA--------PYSSTVFAAVTTDGKAHIFDLAINKYEA 619
++K + I+DL N + + W+ P S+ + A+ + D ++D+
Sbjct: 440 SMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIE----RG 495
Query: 620 ICNQPVAAKKNRLTHVQFN 638
+C + + + V F+
Sbjct: 496 VCTHTLTKHQEPVYSVAFS 514
>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 50.4 bits (119), Expect = 5e-06
Identities = 67/319 (21%), Positives = 120/319 (37%), Gaps = 64/319 (20%)
Query: 340 WNPKYRDLFAVGYGS-----YDFMKQSRG----MLLLYSLKNPSFPEYMFSSNSGVMCLD 390
WNP DL A G G ++ + S G ++L + ++ + SN V LD
Sbjct: 240 WNP-VSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG---HDVPSNKDVTSLD 295
Query: 391 IHVDHPYLVAVGHYDGNVAIYNLKKPHSQPSFCSSAKSGKHSDPVWQVKWQKDDMDQNLN 450
+ + L+A G YDG I+ + S+ G+H P++ +KW + +
Sbjct: 296 WNTNGT-LLATGSYDGFARIWT-----EDGNLASTL--GQHKGPIFALKWNR----KGNY 343
Query: 451 FFSVSSDGRIVSWTLVKRKLVHIDVIKLKVEGSTTEVPEGLQLHPVGCGTAFDFHKEIDY 510
S D + W E Q P A D + +
Sbjct: 344 ILSAGVDKTTIIWD--------------------AHTGEAKQQFPFHSAPALDVDWQNNT 383
Query: 511 MFLVGTEEGKIYKCSKSYSSQFLDTYDAHNMSVDTVSWNPYHTKVFMSCSSDWTVKIWDH 570
F + + I+ C + T+ H V+ + W+P + SCS D T+KIW
Sbjct: 384 TFASCSTDMCIHVCRLGCDRP-VKTFQGHTNEVNAIKWDP-SGMLLASCSDDMTLKIW-- 439
Query: 571 TIKTPMFIYDL---NSAVGDVAWA--------PYSSTVFAAVTTDGKAHIFDLAINKYEA 619
++K + I+DL N + + W+ P S+ + A+ + D ++D+
Sbjct: 440 SMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIE----RG 495
Query: 620 ICNQPVAAKKNRLTHVQFN 638
+C + + + V F+
Sbjct: 496 VCTHTLTKHQEPVYSVAFS 514
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 48.9 bits (115), Expect = 2e-05
Identities = 52/215 (24%), Positives = 83/215 (38%), Gaps = 41/215 (19%)
Query: 382 SNSGVMCLDIHVDHPYLVAVGHYDGNVAIYNLKKPHSQPSFCSSAKSGKHSDPVWQVKWQ 441
SN V LD + + L+A G YDG I+ + S+ G+H P++ +KW
Sbjct: 224 SNKDVTSLDWNSEGT-LLATGSYDGFARIWT-----KDGNLASTL--GQHKGPIFALKWN 275
Query: 442 KDDMDQNLNFF-SVSSDGRIVSWTLVKRKLVHIDVIKLKVEGSTTEVPEGLQLHPVGCGT 500
K NF S D + W E Q P
Sbjct: 276 KKG-----NFILSAGVDKTTIIWD--------------------AHTGEAKQQFPFHSAP 310
Query: 501 AFDFHKEIDYMFLVGTEEGKIYKCSKSYSSQFLDTYDAHNMSVDTVSWNPYHTKVFMSCS 560
A D + + F + + I+ C K + + T+ H V+ + W+P + SCS
Sbjct: 311 ALDVDWQSNNTFASCSTDMCIHVC-KLGQDRPIKTFQGHTNEVNAIKWDPTGN-LLASCS 368
Query: 561 SDWTVKIWDHTIKTPMFIYDL---NSAVGDVAWAP 592
D T+KIW ++K ++DL N + + W+P
Sbjct: 369 DDMTLKIW--SMKQDNCVHDLQAHNKEIYTIKWSP 401
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 47.0 bits (110), Expect = 6e-05
Identities = 32/110 (29%), Positives = 52/110 (47%), Gaps = 5/110 (4%)
Query: 509 DYMFLVGTEEGKIYKCSKSYSSQFLDTYDAHNMSVDTVSWNPYHTKVFMSCSSDWTVKIW 568
D FL E K K Y +FL + H V ++P ++ +SCS D T+KIW
Sbjct: 113 DGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSP-DGRLIVSCSEDKTIKIW 171
Query: 569 DHTIKTPMFIYDLNSAVGDVAWAPY--SSTVFAAVTTDGKAHIFDLAINK 616
D T K + + + +VG + + S T A+ +D ++D+ +NK
Sbjct: 172 DTTNK--QCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNK 219
Score = 35.4 bits (80), Expect = 0.18
Identities = 28/105 (26%), Positives = 47/105 (44%), Gaps = 3/105 (2%)
Query: 509 DYMFLVGTEEGKIYKCSKSYSSQFLDTYDAHNMSVDTVSWNPYHTKVFMSCSSDWTVKIW 568
D +V E K K + + Q ++ + + V +NP T + S SD TVK+W
Sbjct: 155 DGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCI-ASAGSDQTVKVW 213
Query: 569 DHTIKTPMFIYDLNS-AVGDVAWAPYSSTVFAAVTTDGKAHIFDL 612
D + + Y ++S V +++ P S ++DG I DL
Sbjct: 214 DVRVNKLLQHYQVHSGGVNCISFHP-SGNYLITASSDGTLKILDL 257
>gi|4557467 excision repair cross-complementing rodent repair
deficiency, complementation group 8 isoform 1 [Homo
sapiens]
Length = 396
Score = 46.2 bits (108), Expect = 1e-04
Identities = 32/93 (34%), Positives = 44/93 (47%), Gaps = 3/93 (3%)
Query: 522 YKCSKSYSSQFLDTYDAHNMSVDTVSWNPYHTKVFMSCSSDWTVKIWDHTIKTPMFIYDL 581
Y C K+ S D D H SV+TV W P+ T +F S S D T+K+WD +++
Sbjct: 82 YTC-KAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNF 140
Query: 582 NSAVGDVAWAPYSST-VFAAVTTDG-KAHIFDL 612
V +P S+ AV T G K + DL
Sbjct: 141 EETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDL 173
Score = 38.1 bits (87), Expect = 0.028
Identities = 49/194 (25%), Positives = 74/194 (38%), Gaps = 32/194 (16%)
Query: 385 GVMCLDIH-VDHPYLVAVGHYDGNVAIYNLKKPHSQPSF-----CSSAKSGK--HSDPVW 436
G+ LDI V+ Y+++ G DG + +Y+L+ Q + CS + H V
Sbjct: 45 GINTLDIEPVEGRYMLSGGS-DGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVE 103
Query: 437 QVKWQKDDMDQNLNFFSVSSDGRIVSWTLVKRKLVHIDVIKLKVEGSTTEVPEGLQLHPV 496
V+W D F S S D + W L DV + E + PV
Sbjct: 104 TVQWYPHDTGM---FTSSSFDKTLKVWDT--NTLQTADVFNFE------ETVYSHHMSPV 152
Query: 497 GCGTAFDFHKEIDYMFLVGTEEGKIYKCS-KSYSSQFLDTYDAHNMSVDTVSWNPYHTKV 555
+ VGT K+ C KS S + H + VSW+P + +
Sbjct: 153 STKHC---------LVAVGTRGPKVQLCDLKSGSCSHI--LQGHRQEILAVSWSPRYDYI 201
Query: 556 FMSCSSDWTVKIWD 569
+ S+D VK+WD
Sbjct: 202 LATASADSRVKLWD 215
>gi|229892270 WD repeats and SOF1 domain containing [Homo sapiens]
Length = 597
Score = 43.9 bits (102), Expect = 5e-04
Identities = 20/71 (28%), Positives = 35/71 (49%)
Query: 542 SVDTVSWNPYHTKVFMSCSSDWTVKIWDHTIKTPMFIYDLNSAVGDVAWAPYSSTVFAAV 601
S+ +V +NP T + SC+SD + ++D TP+ L+ + W P + +F A
Sbjct: 350 SISSVKFNPIETFLLGSCASDRNIVLYDMRQATPLKKVILDMRTNTICWNPMEAFIFTAA 409
Query: 602 TTDGKAHIFDL 612
D + FD+
Sbjct: 410 NEDYNLYTFDM 420
Score = 36.2 bits (82), Expect = 0.11
Identities = 21/73 (28%), Positives = 39/73 (53%), Gaps = 3/73 (4%)
Query: 540 NMSVDTVSWNPYHTKVFMSCSSDWTVKIWD-HTIKTPMFIY-DLNSAVGDVAWAPYSSTV 597
+M +T+ WNP +F + + D+ + +D + TP+ ++ D SAV DV ++P +
Sbjct: 390 DMRTNTICWNPMEAFIFTAANEDYNLYTFDMRALDTPVMVHMDHVSAVLDVDYSP-TGKE 448
Query: 598 FAAVTTDGKAHIF 610
F + + D IF
Sbjct: 449 FVSASFDKSIRIF 461
>gi|116256340 SEC31 homolog A isoform 3 [Homo sapiens]
Length = 1205
Score = 43.5 bits (101), Expect = 7e-04
Identities = 46/234 (19%), Positives = 91/234 (38%), Gaps = 32/234 (13%)
Query: 386 VMCLDIHVDHPYLVAVGHYDGNVAIYNLKKPHSQPSFCSSAKSGKHSDPVWQVKWQKDDM 445
V LD+++ LVA G + + I++L +F + G + P + +
Sbjct: 125 VRALDVNIFQTNLVASGANESEIYIWDLN------NFATPMTPGAKTQPPEDISCIAWNR 178
Query: 446 DQNLNFFSVSSDGRIVSWTLVKRKLVHIDVIKLKVEGSTTEVP-EGLQLHPVGCGTAFDF 504
S S GR W L K + + +KV + + GL HP
Sbjct: 179 QVQHILASASPSGRATVWDLRKNEPI------IKVSDHSNRMHCSGLAWHP--------- 223
Query: 505 HKEIDYMFLVGTEEGK---IYKCSKSYSSQFLDTYDAHNMSVDTVSWNPYHTKVFMSCSS 561
++ ++ +E+ + I ++S L + H + ++W+ ++ +SC
Sbjct: 224 --DVATQMVLASEDDRLPVIQMWDLRFASSPLRVLENHARGILAIAWSMADPELLLSCGK 281
Query: 562 DWTVKIWDHTIKTPMFIYDLNSAVG---DVAWAPYSSTVFAAVTTDGKAHIFDL 612
D KI T +Y+L + D+ W P + V +A + DG+ ++ +
Sbjct: 282 D--AKILCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSI 333
Score = 31.6 bits (70), Expect = 2.6
Identities = 29/123 (23%), Positives = 51/123 (41%), Gaps = 9/123 (7%)
Query: 503 DFHKEIDYMFLVGTEEGKI--YKCSKSYSSQ---FLDTYDAHNMSVDTVSWNPYHTKVFM 557
D ++ + + G E G I Y SK + + D H V + N + T +
Sbjct: 80 DSKGDVSGVLIAGGENGNIILYDPSKIIAGDKEVVIAQNDKHTGPVRALDVNIFQTNLVA 139
Query: 558 SCSSDWTVKIWD-HTIKTPMFIYDLNSAVGDV---AWAPYSSTVFAAVTTDGKAHIFDLA 613
S +++ + IWD + TPM D+ AW + A+ + G+A ++DL
Sbjct: 140 SGANESEIYIWDLNNFATPMTPGAKTQPPEDISCIAWNRQVQHILASASPSGRATVWDLR 199
Query: 614 INK 616
N+
Sbjct: 200 KNE 202
>gi|116256338 SEC31 homolog A isoform 1 [Homo sapiens]
Length = 1220
Score = 43.5 bits (101), Expect = 7e-04
Identities = 46/234 (19%), Positives = 91/234 (38%), Gaps = 32/234 (13%)
Query: 386 VMCLDIHVDHPYLVAVGHYDGNVAIYNLKKPHSQPSFCSSAKSGKHSDPVWQVKWQKDDM 445
V LD+++ LVA G + + I++L +F + G + P + +
Sbjct: 125 VRALDVNIFQTNLVASGANESEIYIWDLN------NFATPMTPGAKTQPPEDISCIAWNR 178
Query: 446 DQNLNFFSVSSDGRIVSWTLVKRKLVHIDVIKLKVEGSTTEVP-EGLQLHPVGCGTAFDF 504
S S GR W L K + + +KV + + GL HP
Sbjct: 179 QVQHILASASPSGRATVWDLRKNEPI------IKVSDHSNRMHCSGLAWHP--------- 223
Query: 505 HKEIDYMFLVGTEEGK---IYKCSKSYSSQFLDTYDAHNMSVDTVSWNPYHTKVFMSCSS 561
++ ++ +E+ + I ++S L + H + ++W+ ++ +SC
Sbjct: 224 --DVATQMVLASEDDRLPVIQMWDLRFASSPLRVLENHARGILAIAWSMADPELLLSCGK 281
Query: 562 DWTVKIWDHTIKTPMFIYDLNSAVG---DVAWAPYSSTVFAAVTTDGKAHIFDL 612
D KI T +Y+L + D+ W P + V +A + DG+ ++ +
Sbjct: 282 D--AKILCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSI 333
Score = 31.6 bits (70), Expect = 2.6
Identities = 29/123 (23%), Positives = 51/123 (41%), Gaps = 9/123 (7%)
Query: 503 DFHKEIDYMFLVGTEEGKI--YKCSKSYSSQ---FLDTYDAHNMSVDTVSWNPYHTKVFM 557
D ++ + + G E G I Y SK + + D H V + N + T +
Sbjct: 80 DSKGDVSGVLIAGGENGNIILYDPSKIIAGDKEVVIAQNDKHTGPVRALDVNIFQTNLVA 139
Query: 558 SCSSDWTVKIWD-HTIKTPMFIYDLNSAVGDV---AWAPYSSTVFAAVTTDGKAHIFDLA 613
S +++ + IWD + TPM D+ AW + A+ + G+A ++DL
Sbjct: 140 SGANESEIYIWDLNNFATPMTPGAKTQPPEDISCIAWNRQVQHILASASPSGRATVWDLR 199
Query: 614 INK 616
N+
Sbjct: 200 KNE 202
>gi|116256336 SEC31 homolog A isoform 4 [Homo sapiens]
Length = 1106
Score = 43.5 bits (101), Expect = 7e-04
Identities = 46/234 (19%), Positives = 91/234 (38%), Gaps = 32/234 (13%)
Query: 386 VMCLDIHVDHPYLVAVGHYDGNVAIYNLKKPHSQPSFCSSAKSGKHSDPVWQVKWQKDDM 445
V LD+++ LVA G + + I++L +F + G + P + +
Sbjct: 125 VRALDVNIFQTNLVASGANESEIYIWDLN------NFATPMTPGAKTQPPEDISCIAWNR 178
Query: 446 DQNLNFFSVSSDGRIVSWTLVKRKLVHIDVIKLKVEGSTTEVP-EGLQLHPVGCGTAFDF 504
S S GR W L K + + +KV + + GL HP
Sbjct: 179 QVQHILASASPSGRATVWDLRKNEPI------IKVSDHSNRMHCSGLAWHP--------- 223
Query: 505 HKEIDYMFLVGTEEGK---IYKCSKSYSSQFLDTYDAHNMSVDTVSWNPYHTKVFMSCSS 561
++ ++ +E+ + I ++S L + H + ++W+ ++ +SC
Sbjct: 224 --DVATQMVLASEDDRLPVIQMWDLRFASSPLRVLENHARGILAIAWSMADPELLLSCGK 281
Query: 562 DWTVKIWDHTIKTPMFIYDLNSAVG---DVAWAPYSSTVFAAVTTDGKAHIFDL 612
D KI T +Y+L + D+ W P + V +A + DG+ ++ +
Sbjct: 282 D--AKILCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSI 333
Score = 31.6 bits (70), Expect = 2.6
Identities = 29/123 (23%), Positives = 51/123 (41%), Gaps = 9/123 (7%)
Query: 503 DFHKEIDYMFLVGTEEGKI--YKCSKSYSSQ---FLDTYDAHNMSVDTVSWNPYHTKVFM 557
D ++ + + G E G I Y SK + + D H V + N + T +
Sbjct: 80 DSKGDVSGVLIAGGENGNIILYDPSKIIAGDKEVVIAQNDKHTGPVRALDVNIFQTNLVA 139
Query: 558 SCSSDWTVKIWD-HTIKTPMFIYDLNSAVGDV---AWAPYSSTVFAAVTTDGKAHIFDLA 613
S +++ + IWD + TPM D+ AW + A+ + G+A ++DL
Sbjct: 140 SGANESEIYIWDLNNFATPMTPGAKTQPPEDISCIAWNRQVQHILASASPSGRATVWDLR 199
Query: 614 INK 616
N+
Sbjct: 200 KNE 202
>gi|41349441 SEC31 homolog A isoform 2 [Homo sapiens]
Length = 1181
Score = 43.5 bits (101), Expect = 7e-04
Identities = 46/234 (19%), Positives = 91/234 (38%), Gaps = 32/234 (13%)
Query: 386 VMCLDIHVDHPYLVAVGHYDGNVAIYNLKKPHSQPSFCSSAKSGKHSDPVWQVKWQKDDM 445
V LD+++ LVA G + + I++L +F + G + P + +
Sbjct: 125 VRALDVNIFQTNLVASGANESEIYIWDLN------NFATPMTPGAKTQPPEDISCIAWNR 178
Query: 446 DQNLNFFSVSSDGRIVSWTLVKRKLVHIDVIKLKVEGSTTEVP-EGLQLHPVGCGTAFDF 504
S S GR W L K + + +KV + + GL HP
Sbjct: 179 QVQHILASASPSGRATVWDLRKNEPI------IKVSDHSNRMHCSGLAWHP--------- 223
Query: 505 HKEIDYMFLVGTEEGK---IYKCSKSYSSQFLDTYDAHNMSVDTVSWNPYHTKVFMSCSS 561
++ ++ +E+ + I ++S L + H + ++W+ ++ +SC
Sbjct: 224 --DVATQMVLASEDDRLPVIQMWDLRFASSPLRVLENHARGILAIAWSMADPELLLSCGK 281
Query: 562 DWTVKIWDHTIKTPMFIYDLNSAVG---DVAWAPYSSTVFAAVTTDGKAHIFDL 612
D KI T +Y+L + D+ W P + V +A + DG+ ++ +
Sbjct: 282 D--AKILCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSI 333
Score = 31.6 bits (70), Expect = 2.6
Identities = 29/123 (23%), Positives = 51/123 (41%), Gaps = 9/123 (7%)
Query: 503 DFHKEIDYMFLVGTEEGKI--YKCSKSYSSQ---FLDTYDAHNMSVDTVSWNPYHTKVFM 557
D ++ + + G E G I Y SK + + D H V + N + T +
Sbjct: 80 DSKGDVSGVLIAGGENGNIILYDPSKIIAGDKEVVIAQNDKHTGPVRALDVNIFQTNLVA 139
Query: 558 SCSSDWTVKIWD-HTIKTPMFIYDLNSAVGDV---AWAPYSSTVFAAVTTDGKAHIFDLA 613
S +++ + IWD + TPM D+ AW + A+ + G+A ++DL
Sbjct: 140 SGANESEIYIWDLNNFATPMTPGAKTQPPEDISCIAWNRQVQHILASASPSGRATVWDLR 199
Query: 614 INK 616
N+
Sbjct: 200 KNE 202
>gi|41349439 SEC31 homolog A isoform 1 [Homo sapiens]
Length = 1220
Score = 43.5 bits (101), Expect = 7e-04
Identities = 46/234 (19%), Positives = 91/234 (38%), Gaps = 32/234 (13%)
Query: 386 VMCLDIHVDHPYLVAVGHYDGNVAIYNLKKPHSQPSFCSSAKSGKHSDPVWQVKWQKDDM 445
V LD+++ LVA G + + I++L +F + G + P + +
Sbjct: 125 VRALDVNIFQTNLVASGANESEIYIWDLN------NFATPMTPGAKTQPPEDISCIAWNR 178
Query: 446 DQNLNFFSVSSDGRIVSWTLVKRKLVHIDVIKLKVEGSTTEVP-EGLQLHPVGCGTAFDF 504
S S GR W L K + + +KV + + GL HP
Sbjct: 179 QVQHILASASPSGRATVWDLRKNEPI------IKVSDHSNRMHCSGLAWHP--------- 223
Query: 505 HKEIDYMFLVGTEEGK---IYKCSKSYSSQFLDTYDAHNMSVDTVSWNPYHTKVFMSCSS 561
++ ++ +E+ + I ++S L + H + ++W+ ++ +SC
Sbjct: 224 --DVATQMVLASEDDRLPVIQMWDLRFASSPLRVLENHARGILAIAWSMADPELLLSCGK 281
Query: 562 DWTVKIWDHTIKTPMFIYDLNSAVG---DVAWAPYSSTVFAAVTTDGKAHIFDL 612
D KI T +Y+L + D+ W P + V +A + DG+ ++ +
Sbjct: 282 D--AKILCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSI 333
Score = 31.6 bits (70), Expect = 2.6
Identities = 29/123 (23%), Positives = 51/123 (41%), Gaps = 9/123 (7%)
Query: 503 DFHKEIDYMFLVGTEEGKI--YKCSKSYSSQ---FLDTYDAHNMSVDTVSWNPYHTKVFM 557
D ++ + + G E G I Y SK + + D H V + N + T +
Sbjct: 80 DSKGDVSGVLIAGGENGNIILYDPSKIIAGDKEVVIAQNDKHTGPVRALDVNIFQTNLVA 139
Query: 558 SCSSDWTVKIWD-HTIKTPMFIYDLNSAVGDV---AWAPYSSTVFAAVTTDGKAHIFDLA 613
S +++ + IWD + TPM D+ AW + A+ + G+A ++DL
Sbjct: 140 SGANESEIYIWDLNNFATPMTPGAKTQPPEDISCIAWNRQVQHILASASPSGRATVWDLR 199
Query: 614 INK 616
N+
Sbjct: 200 KNE 202
>gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens]
Length = 1298
Score = 42.4 bits (98), Expect = 0.001
Identities = 49/194 (25%), Positives = 81/194 (41%), Gaps = 31/194 (15%)
Query: 398 LVAVGHYDGNVAIYNLKKPHSQPSFCSSAKSGKHSDPVWQVKWQKDDMDQNLNFFSVSSD 457
++A G D NV +Y + QP S H+ V+ VKW + + + S S D
Sbjct: 512 MIATGCEDTNVRVYYVATSSDQPLKVFSG----HTAKVFHVKWSP--LREGI-LCSGSDD 564
Query: 458 GRIVSWTLVKRKLVHIDVIKLKVEGSTTEVPEGLQLHPVGCGTAFDFHKEIDYMFLVGTE 517
G + W + ++I + G T V GL ++ EI Y+ + G+
Sbjct: 565 GTVRIWDYTQDACINI------LNGHTAPV-RGLM-----------WNTEIPYLLISGSW 606
Query: 518 EGKIYKCSKSYSSQFLDTYDAHNMSVDTVSWNPYHTKVFMSCSSDWTVKIWDHT-IKTPM 576
+ I K + +DT H V ++ +P SCS D TV++W T + TP+
Sbjct: 607 DYTI-KVWDTREGTCVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSLTALVTPV 665
Query: 577 FIYDLNSAVGDVAW 590
I + + D +W
Sbjct: 666 QI----NILADRSW 675
Score = 38.9 bits (89), Expect = 0.016
Identities = 27/83 (32%), Positives = 38/83 (45%), Gaps = 10/83 (12%)
Query: 494 HPV---GCGTAFDFHKEIDYMFLVGTEEG--KIYKCSKSYSSQFLDTYDAHNMSVDTVSW 548
HP GC D+ + M G E+ ++Y + S S Q L + H V V W
Sbjct: 496 HPAAVFGC----DWSQNNKDMIATGCEDTNVRVYYVATS-SDQPLKVFSGHTAKVFHVKW 550
Query: 549 NPYHTKVFMSCSSDWTVKIWDHT 571
+P + S S D TV+IWD+T
Sbjct: 551 SPLREGILCSGSDDGTVRIWDYT 573
Score = 32.0 bits (71), Expect = 2.0
Identities = 21/78 (26%), Positives = 38/78 (48%), Gaps = 5/78 (6%)
Query: 539 HNMSVDTVSWNPYHTKVFMSCSSDWTVKIWDHTIKTPMFIYDLNSAVG---DVAWAPYSS 595
H ++ +SW P++ +F S S+D V IW+ + I L+S G ++W +
Sbjct: 58 HKKTITAISWCPHNPDLFASGSTDNLVIIWN--VAEQKVIAKLDSTKGIPASLSWCWNAE 115
Query: 596 TVFAAVTTDGKAHIFDLA 613
V A V+ G I+ ++
Sbjct: 116 DVVAFVSHRGPLFIWTIS 133
Score = 30.8 bits (68), Expect = 4.5
Identities = 19/81 (23%), Positives = 36/81 (44%), Gaps = 1/81 (1%)
Query: 533 LDTYDAHNMSVDTVSWNPYHTKVFMSCSSDWTVKIWDHTIKTPM-FIYDLNSAVGDVAWA 591
++ + H V + WN + +S S D+T+K+WD T + +YD + V +
Sbjct: 578 INILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCH 637
Query: 592 PYSSTVFAAVTTDGKAHIFDL 612
P A+ + D ++ L
Sbjct: 638 PSRPFTMASCSRDSTVRLWSL 658
Score = 30.0 bits (66), Expect = 7.6
Identities = 19/79 (24%), Positives = 34/79 (43%), Gaps = 1/79 (1%)
Query: 539 HNMSVDTVSWNPYHTKVFMSCSSDWTVKIWDHTIKTPMFIYDLNSAV-GDVAWAPYSSTV 597
H ++ + P + + S D T+K+WD T ++ N V ++WAP
Sbjct: 368 HVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGLNC 427
Query: 598 FAAVTTDGKAHIFDLAINK 616
A T+ A I+++ K
Sbjct: 428 IAGGTSRNGAFIWNVQKGK 446
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.131 0.386
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,596,188
Number of Sequences: 37866
Number of extensions: 1287788
Number of successful extensions: 4761
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 62
Number of HSP's successfully gapped in prelim test: 228
Number of HSP's that attempted gapping in prelim test: 4186
Number of HSP's gapped (non-prelim): 666
length of query: 699
length of database: 18,247,518
effective HSP length: 109
effective length of query: 590
effective length of database: 14,120,124
effective search space: 8330873160
effective search space used: 8330873160
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.