Search of human proteins with 6912278

Search of human proteins with 6912278

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|6912278 COMM domain containing 3 [Homo sapiens]
         (195 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|6912278 COMM domain containing 3 [Homo sapiens]                    389   e-109
gi|45545435 COMM domain containing 2 [Homo sapiens]                    40   0.001
gi|7706663 COMM domain containing 10 [Homo sapiens]                    39   0.004
gi|156416007 COMM domain containing 9 isoform 2 [Homo sapiens]         38   0.006
gi|156416005 COMM domain containing 9 isoform 1 [Homo sapiens]         38   0.006
gi|124487382 COMM domain containing 5 [Homo sapiens]                   37   0.014
gi|154800418 COMM domain containing 5 [Homo sapiens]                   37   0.014
gi|19923430 COMM domain containing 5 [Homo sapiens]                    37   0.014
gi|134244285 Notch homolog 3 [Homo sapiens]                            33   0.20 
gi|115387102 adenylate cyclase 2 [Homo sapiens]                        32   0.34 
gi|89941470 ankyrin repeat domain 34 [Homo sapiens]                    30   1.3  
gi|146229340 mutated in colorectal cancers isoform 1 [Homo sapiens]    29   2.9  
gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax ...    29   2.9  
gi|4505129 mutated in colorectal cancers isoform 2 [Homo sapiens]      29   2.9  
gi|157419140 laminin, gamma 2 isoform b precursor [Homo sapiens]       27   8.4  
gi|157419138 laminin, gamma 2 isoform a precursor [Homo sapiens]       27   8.4  

>gi|6912278 COMM domain containing 3 [Homo sapiens]
          Length = 195

 Score =  389 bits (1000), Expect = e-109
 Identities = 195/195 (100%), Positives = 195/195 (100%)

Query: 1   MELSESVQKGFQMLADPRSFDSNAFTLLLRAAFQSLLDAQADEAVLDHPDLKHIDPVVLK 60
           MELSESVQKGFQMLADPRSFDSNAFTLLLRAAFQSLLDAQADEAVLDHPDLKHIDPVVLK
Sbjct: 1   MELSESVQKGFQMLADPRSFDSNAFTLLLRAAFQSLLDAQADEAVLDHPDLKHIDPVVLK 60

Query: 61  HCHAAAATYILEAGKHRADKSTLSTYLEDCKFDRERIELFCTEYQNNKNSLEILLGSIGR 120
           HCHAAAATYILEAGKHRADKSTLSTYLEDCKFDRERIELFCTEYQNNKNSLEILLGSIGR
Sbjct: 61  HCHAAAATYILEAGKHRADKSTLSTYLEDCKFDRERIELFCTEYQNNKNSLEILLGSIGR 120

Query: 121 SLPHITDVSWRLEYQIKTNQLHRMYRPAYLVTLSVQNTDSPSYPEISFSCSMEQLQDLVG 180
           SLPHITDVSWRLEYQIKTNQLHRMYRPAYLVTLSVQNTDSPSYPEISFSCSMEQLQDLVG
Sbjct: 121 SLPHITDVSWRLEYQIKTNQLHRMYRPAYLVTLSVQNTDSPSYPEISFSCSMEQLQDLVG 180

Query: 181 KLKDASKSLERATQL 195
           KLKDASKSLERATQL
Sbjct: 181 KLKDASKSLERATQL 195


>gi|45545435 COMM domain containing 2 [Homo sapiens]
          Length = 199

 Score = 40.0 bits (92), Expect = 0.001
 Identities = 20/69 (28%), Positives = 35/69 (50%), Gaps = 1/69 (1%)

Query: 92  FDRERIELFCTEYQNNKNSLEILLGSIGRSLPHITDVSWRLEYQIKTNQLHRMYRPAYLV 151
           F  E  +L    Y +N+  +  +L  +  SLP   ++ WRL+ Q+ +  L +  +PA  +
Sbjct: 91  FSEELNKLLLQLYLDNRKEIRTILSELAPSLPSYHNLEWRLDVQLASRSLRQQIKPAVTI 150

Query: 152 TLSV-QNTD 159
            L + QN D
Sbjct: 151 KLHLNQNGD 159


>gi|7706663 COMM domain containing 10 [Homo sapiens]
          Length = 202

 Score = 38.5 bits (88), Expect = 0.004
 Identities = 44/195 (22%), Positives = 82/195 (42%), Gaps = 9/195 (4%)

Query: 4   SESVQKGFQMLADPRSFDSNAFTLLLRAAFQSL-LDAQADEAVLDHPDLKHIDPVVLKHC 62
           S S++K   ++    + D+  F  LL    Q L L A++  +  +   L+    +  +  
Sbjct: 12  SPSMKKAVSLI---NAIDTGRFPRLLTRILQKLHLKAESSFSEEEEEKLQAAFSLEKQDL 68

Query: 63  HAAAAT--YILE-AGKHRADKSTLSTYLEDCKFDRERIELFCTEYQN-NKNSLEILLGSI 118
           H    T  +ILE A  H    + L   LE+    +++ E F   + +  + ++E     I
Sbjct: 69  HLVLETISFILEQAVYHNVKPAALQQQLENIHLRQDKAEAFVNTWSSMGQETVEKFRQRI 128

Query: 119 GRSLPHITDVSWRLEYQIKTNQLHRMYRPAYLVTLSVQNTDSPSYPEISFSCSMEQLQDL 178
                 +  V W+L  Q+  +   ++  P  ++ L V N DS S  ++    S ++L D 
Sbjct: 129 LAPCK-LETVGWQLNLQMAHSAQAKLKSPQAVLQLGVNNEDSKSLEKVLVEFSHKELFDF 187

Query: 179 VGKLKDASKSLERAT 193
             KL+     L+  T
Sbjct: 188 YNKLETIQAQLDSLT 202


>gi|156416007 COMM domain containing 9 isoform 2 [Homo sapiens]
          Length = 156

 Score = 37.7 bits (86), Expect = 0.006
 Identities = 20/72 (27%), Positives = 37/72 (51%), Gaps = 8/72 (11%)

Query: 121 SLPHITDVSWRLEYQIKTNQLHRMYRPAYLVTLSVQNT-----DSPSYPEISFSCSMEQL 175
           SLP + D+ WR++ +  ++ + RM  P  L+ + +Q       D PS   ++   S E L
Sbjct: 77  SLPRLVDLDWRVDIKTSSDSISRMAVPTCLLQMKIQEDPSLCGDKPSISAVTVELSKETL 136

Query: 176 Q---DLVGKLKD 184
               D +G+++D
Sbjct: 137 DTMLDGLGRIRD 148


>gi|156416005 COMM domain containing 9 isoform 1 [Homo sapiens]
          Length = 198

 Score = 37.7 bits (86), Expect = 0.006
 Identities = 20/72 (27%), Positives = 37/72 (51%), Gaps = 8/72 (11%)

Query: 121 SLPHITDVSWRLEYQIKTNQLHRMYRPAYLVTLSVQNT-----DSPSYPEISFSCSMEQL 175
           SLP + D+ WR++ +  ++ + RM  P  L+ + +Q       D PS   ++   S E L
Sbjct: 119 SLPRLVDLDWRVDIKTSSDSISRMAVPTCLLQMKIQEDPSLCGDKPSISAVTVELSKETL 178

Query: 176 Q---DLVGKLKD 184
               D +G+++D
Sbjct: 179 DTMLDGLGRIRD 190


>gi|124487382 COMM domain containing 5 [Homo sapiens]
          Length = 224

 Score = 36.6 bits (83), Expect = 0.014
 Identities = 23/80 (28%), Positives = 38/80 (47%), Gaps = 6/80 (7%)

Query: 119 GRSLPHITDVSWRLEYQIKTNQLHRMYRPAYLVTLSVQNTDSPSY----PEISFSCSMEQ 174
           G  LPH+ D  WR++  I T+ L R  +P+ L+ L +  +D  +Y    P   F      
Sbjct: 146 GAWLPHVADFRWRVDVAISTSALARSLQPSVLMQLKL--SDGSAYRFEVPTAKFQELRYS 203

Query: 175 LQDLVGKLKDASKSLERATQ 194
           +  ++ ++ D  K  ER  Q
Sbjct: 204 VALVLKEMADLEKRCERRLQ 223


>gi|154800418 COMM domain containing 5 [Homo sapiens]
          Length = 224

 Score = 36.6 bits (83), Expect = 0.014
 Identities = 23/80 (28%), Positives = 38/80 (47%), Gaps = 6/80 (7%)

Query: 119 GRSLPHITDVSWRLEYQIKTNQLHRMYRPAYLVTLSVQNTDSPSY----PEISFSCSMEQ 174
           G  LPH+ D  WR++  I T+ L R  +P+ L+ L +  +D  +Y    P   F      
Sbjct: 146 GAWLPHVADFRWRVDVAISTSALARSLQPSVLMQLKL--SDGSAYRFEVPTAKFQELRYS 203

Query: 175 LQDLVGKLKDASKSLERATQ 194
           +  ++ ++ D  K  ER  Q
Sbjct: 204 VALVLKEMADLEKRCERRLQ 223


>gi|19923430 COMM domain containing 5 [Homo sapiens]
          Length = 224

 Score = 36.6 bits (83), Expect = 0.014
 Identities = 23/80 (28%), Positives = 38/80 (47%), Gaps = 6/80 (7%)

Query: 119 GRSLPHITDVSWRLEYQIKTNQLHRMYRPAYLVTLSVQNTDSPSY----PEISFSCSMEQ 174
           G  LPH+ D  WR++  I T+ L R  +P+ L+ L +  +D  +Y    P   F      
Sbjct: 146 GAWLPHVADFRWRVDVAISTSALARSLQPSVLMQLKL--SDGSAYRFEVPTAKFQELRYS 203

Query: 175 LQDLVGKLKDASKSLERATQ 194
           +  ++ ++ D  K  ER  Q
Sbjct: 204 VALVLKEMADLEKRCERRLQ 223


>gi|134244285 Notch homolog 3 [Homo sapiens]
          Length = 2321

 Score = 32.7 bits (73), Expect = 0.20
 Identities = 38/150 (25%), Positives = 64/150 (42%), Gaps = 20/150 (13%)

Query: 3    LSESVQKGFQMLADPRSFDSNA-----FTLLLRAAFQSLLDAQADEAVLDHPDLKHIDPV 57
            ++   Q  FQ+L   RS D +A      T L+ AA +  ++   +E +  H D+  +D +
Sbjct: 1880 VTADAQGVFQILIRNRSTDLDARMADGSTALILAA-RLAVEGMVEELIASHADVNAVDEL 1938

Query: 58   VLKHCHAAAATYILEAG----KHRADKSTLSTYLEDCKFDRERIELFCTEYQNNKNSLEI 113
                 H AAA   +EA     K+ A+K        D +  +E   LF    + +  + ++
Sbjct: 1939 GKSALHWAAAVNNVEATLALLKNGANK--------DMQDSKEETPLFLAAREGSYEAAKL 1990

Query: 114  LLGSIGRSLPHITDVSWRLEYQIKTNQLHR 143
            LL         ITD   RL   +   +LH+
Sbjct: 1991 LLDHFANR--EITDHLDRLPRDVAQERLHQ 2018


>gi|115387102 adenylate cyclase 2 [Homo sapiens]
          Length = 1091

 Score = 32.0 bits (71), Expect = 0.34
 Identities = 32/143 (22%), Positives = 56/143 (39%), Gaps = 16/143 (11%)

Query: 57  VVLKHCHAAAATYILEAGKHRADKSTLSTYLEDCKFDRERIELFCTEYQNNKNSLEILLG 116
           V++  C   A  Y     KH  + +   TY + C   + RI+L   + Q  +  L +L  
Sbjct: 195 VIIFICGNLAGAY----HKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPA 250

Query: 117 SIGRSLPHITDVSWRLE-----YQIKTNQLHRMYRPAYLVTLSVQNTDSPSYPEISFSCS 171
            I   +    ++  RL+         TN  H +Y   +   +S+   D   +  ++  CS
Sbjct: 251 HIAMEMK--AEIIQRLQGPKAGQMENTNNFHNLYVKRH-TNVSILYADIVGFTRLASDCS 307

Query: 172 ----MEQLQDLVGKLKDASKSLE 190
               +  L +L GK    +K  E
Sbjct: 308 PGELVHMLNELFGKFDQIAKENE 330


>gi|89941470 ankyrin repeat domain 34 [Homo sapiens]
          Length = 496

 Score = 30.0 bits (66), Expect = 1.3
 Identities = 27/90 (30%), Positives = 38/90 (42%), Gaps = 11/90 (12%)

Query: 15  ADPRSFDSNAFTLLLRAAFQSLLDAQADEAVLDHPDLKH-IDPVVLKHCHAAAATYILEA 73
           ADP   D    T L+ A       A    A +    L H  DP V  H  A+A  + L+ 
Sbjct: 68  ADPNIADRLGRTALMHAC------AGGGGAAVASLLLAHGADPSVRDHAGASALVHALDR 121

Query: 74  GKHRADKSTLSTYLEDCKFDRERIELFCTE 103
           G    D+ TL+T L+ CK     + +  T+
Sbjct: 122 G----DRETLATLLDACKAKGTEVIIITTD 147


>gi|146229340 mutated in colorectal cancers isoform 1 [Homo sapiens]
          Length = 1019

 Score = 28.9 bits (63), Expect = 2.9
 Identities = 11/39 (28%), Positives = 23/39 (58%)

Query: 77  RADKSTLSTYLEDCKFDRERIELFCTEYQNNKNSLEILL 115
           ++    L+  LE+CK + ER+ +   +Y++N  +L + L
Sbjct: 601 KSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLAL 639


>gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax
            homolog 2 [Homo sapiens]
          Length = 1210

 Score = 28.9 bits (63), Expect = 2.9
 Identities = 15/61 (24%), Positives = 30/61 (49%)

Query: 91   KFDRERIELFCTEYQNNKNSLEILLGSIGRSLPHITDVSWRLEYQIKTNQLHRMYRPAYL 150
            KFD+++ +L   E +  K   E++   +G++  ++  V   +E  I T    +  + AY 
Sbjct: 958  KFDKQQADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYS 1017

Query: 151  V 151
            V
Sbjct: 1018 V 1018


>gi|4505129 mutated in colorectal cancers isoform 2 [Homo sapiens]
          Length = 829

 Score = 28.9 bits (63), Expect = 2.9
 Identities = 11/39 (28%), Positives = 23/39 (58%)

Query: 77  RADKSTLSTYLEDCKFDRERIELFCTEYQNNKNSLEILL 115
           ++    L+  LE+CK + ER+ +   +Y++N  +L + L
Sbjct: 411 KSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLAL 449


>gi|157419140 laminin, gamma 2 isoform b precursor [Homo sapiens]
          Length = 1111

 Score = 27.3 bits (59), Expect = 8.4
 Identities = 14/52 (26%), Positives = 26/52 (50%)

Query: 71  LEAGKHRADKSTLSTYLEDCKFDRERIELFCTEYQNNKNSLEILLGSIGRSL 122
           L+  K R+ +++  + L+D K   ER+    ++YQN       L+  +  SL
Sbjct: 679 LQLAKVRSQENSYQSRLDDLKMTVERVRALGSQYQNRVRDTHRLITQMQLSL 730


>gi|157419138 laminin, gamma 2 isoform a precursor [Homo sapiens]
          Length = 1193

 Score = 27.3 bits (59), Expect = 8.4
 Identities = 14/52 (26%), Positives = 26/52 (50%)

Query: 71  LEAGKHRADKSTLSTYLEDCKFDRERIELFCTEYQNNKNSLEILLGSIGRSL 122
           L+  K R+ +++  + L+D K   ER+    ++YQN       L+  +  SL
Sbjct: 679 LQLAKVRSQENSYQSRLDDLKMTVERVRALGSQYQNRVRDTHRLITQMQLSL 730


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.131    0.375 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 6,618,337
Number of Sequences: 37866
Number of extensions: 262932
Number of successful extensions: 728
Number of sequences better than 10.0: 16
Number of HSP's better than 10.0 without gapping: 13
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 715
Number of HSP's gapped (non-prelim): 16
length of query: 195
length of database: 18,247,518
effective HSP length: 97
effective length of query: 98
effective length of database: 14,574,516
effective search space: 1428302568
effective search space used: 1428302568
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 59 (27.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.