Search of human proteins with 67514036

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|67514036 SH3-domain kinase binding protein 1 isoform b [Homo
sapiens]
         (628 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|67514036 SH3-domain kinase binding protein 1 isoform b [Homo ...  1246   0.0  
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ...  1216   0.0  
gi|11321634 CD2-associated protein [Homo sapiens]                     319   4e-87
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]                87   6e-17
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]                87   6e-17
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H...    83   9e-16
gi|242117948 SH3 domain-containing protein C1orf113 isoform 2 [H...    83   9e-16
gi|39930351 dynamin binding protein [Homo sapiens]                     79   1e-14
gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo sa...    78   3e-14
gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo s...    78   3e-14
gi|194294523 intersectin 2 isoform 3 [Homo sapiens]                    75   2e-13
gi|194294521 intersectin 2 isoform 1 [Homo sapiens]                    75   2e-13
gi|194294525 intersectin 2 isoform 2 [Homo sapiens]                    75   2e-13
gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo s...    69   1e-11
gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo s...    69   2e-11
gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo s...    69   2e-11
gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo...    69   2e-11
gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ...    66   8e-11
gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo ...    66   8e-11
gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ...    66   8e-11
gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ...    66   8e-11
gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ...    66   8e-11
gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo ...    66   8e-11
gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo s...    66   8e-11
gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo ...    66   8e-11
gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo ...    66   1e-10
gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo s...    66   1e-10
gi|166064036 PAK-interacting exchange factor beta isoform d [Hom...    65   2e-10
gi|166064034 PAK-interacting exchange factor beta isoform c [Hom...    65   2e-10
gi|22027528 PAK-interacting exchange factor beta isoform b [Homo...    65   2e-10

>gi|67514036 SH3-domain kinase binding protein 1 isoform b [Homo
           sapiens]
          Length = 628

 Score = 1246 bits (3223), Expect = 0.0
 Identities = 628/628 (100%), Positives = 628/628 (100%)

Query: 1   MEVSAAKAPSAADLSEIEIKKEMKKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGE 60
           MEVSAAKAPSAADLSEIEIKKEMKKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGE
Sbjct: 1   MEVSAAKAPSAADLSEIEIKKEMKKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGE 60

Query: 61  RRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSG 120
           RRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSG
Sbjct: 61  RRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSG 120

Query: 121 ESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGD 180
           ESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGD
Sbjct: 121 ESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGD 180

Query: 181 IFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFP 240
           IFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFP
Sbjct: 181 IFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFP 240

Query: 241 YEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRP 300
           YEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRP
Sbjct: 241 YEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRP 300

Query: 301 KKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPA 360
           KKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPA
Sbjct: 301 KKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPA 360

Query: 361 IPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDR 420
           IPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDR
Sbjct: 361 IPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDR 420

Query: 421 SNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKE 480
           SNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKE
Sbjct: 421 SNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKE 480

Query: 481 EHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLSSS 540
           EHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLSSS
Sbjct: 481 EHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLSSS 540

Query: 541 LGTAGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQL 600
           LGTAGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQL
Sbjct: 541 LGTAGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQL 600

Query: 601 LSELDEEKKIRLRLQMEVNDIKKALQSK 628
           LSELDEEKKIRLRLQMEVNDIKKALQSK
Sbjct: 601 LSELDEEKKIRLRLQMEVNDIKKALQSK 628


>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
           sapiens]
          Length = 665

 Score = 1216 bits (3146), Expect = 0.0
 Identities = 611/611 (100%), Positives = 611/611 (100%)

Query: 18  EIKKEMKKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQND 77
           EIKKEMKKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQND
Sbjct: 55  EIKKEMKKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQND 114

Query: 78  DELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSS 137
           DELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSS
Sbjct: 115 DELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSS 174

Query: 138 LRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVE 197
           LRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVE
Sbjct: 175 LRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVE 234

Query: 198 NDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIV 257
           NDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIV
Sbjct: 235 NDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIV 294

Query: 258 TLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGT 317
           TLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGT
Sbjct: 295 TLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGT 354

Query: 318 TERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRP 377
           TERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRP
Sbjct: 355 TERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRP 414

Query: 378 GALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTE 437
           GALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTE
Sbjct: 415 GALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTE 474

Query: 438 KLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTS 497
           KLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTS
Sbjct: 475 KLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTS 534

Query: 498 KTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLSSSLGTAGHRANSPSLFGTE 557
           KTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLSSSLGTAGHRANSPSLFGTE
Sbjct: 535 KTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLSSSLGTAGHRANSPSLFGTE 594

Query: 558 GKPKMEPAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDEEKKIRLRLQME 617
           GKPKMEPAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDEEKKIRLRLQME
Sbjct: 595 GKPKMEPAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDEEKKIRLRLQME 654

Query: 618 VNDIKKALQSK 628
           VNDIKKALQSK
Sbjct: 655 VNDIKKALQSK 665



 Score = 79.7 bits (195), Expect = 7e-15
 Identities = 37/70 (52%), Positives = 50/70 (71%), Gaps = 2/70 (2%)

Query: 237 VIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKE 296
           V F Y+AQ+DDELTI  G+I+T I K+  D GWWEG++NGRRG+FPDNFV+ +  + +K+
Sbjct: 6   VEFDYQAQHDDELTISVGEIITNIRKE--DGGWWEGQINGRRGLFPDNFVREIKKEMKKD 63

Query: 297 GNRPKKPPPP 306
               K P  P
Sbjct: 64  PLTNKAPEKP 73



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 26/54 (48%), Positives = 38/54 (70%)

Query: 68  VAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGE 121
           V F Y  Q+DDEL + VG+II  + + + GWWEG +NG+ G+FP NF++E+  E
Sbjct: 6   VEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKE 59


>gi|11321634 CD2-associated protein [Homo sapiens]
          Length = 639

 Score =  319 bits (818), Expect = 4e-87
 Identities = 215/599 (35%), Positives = 312/599 (52%), Gaps = 90/599 (15%)

Query: 56  NKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFI 115
           N + + ++R+C+V F Y+PQN+DELELKVGDII++  EVEEGWW G LN K G+FPSNF+
Sbjct: 103 NIKKKTKKRQCKVLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFV 162

Query: 116 KELSGESD-ELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVK 174
           KEL    D E   +QD+  S++ L   T      G+ S T    A+G+V     QPKK++
Sbjct: 163 KELEVTDDGETHEAQDD--SETVLAGPTSPIPSLGNVSET----ASGSVT----QPKKIR 212

Query: 175 GVGFGDIFKDKPIKLRPRSIEVENDFLPVEK-TIGKKLPATTATPDSSKTEMDSRTKSKD 233
           G+GFGDIFK+  +KLR R+   E +    EK  I + L   T + + +KT+ + + K+K+
Sbjct: 213 GIGFGDIFKEGSVKLRTRTSSSETEEKKPEKPLILQSLGPKTQSVEITKTDTEGKIKAKE 272

Query: 234 YCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDF 293
           YC+ +F YE  N+DELT KEG+I+ LI+K+  + GWW GELNG+ GVFPDNF   +  + 
Sbjct: 273 YCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQI-NEL 331

Query: 294 EKEGNRPKKPPPPS-APVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLD 352
           +K+  +PKKPPPP+ AP  K      E+K+   K         P   +EK   E++P   
Sbjct: 332 DKDFPKPKKPPPPAKAPAPKPELIAAEKKYFSLK---------PEEKDEKSTLEQKP--- 379

Query: 353 LQKPSVPAIPPKKPRPP--KTNSLSRPGALPPRRPERPV--------------------- 389
             KP+ P +PPKKP PP   +N L   G + P+RPE+PV                     
Sbjct: 380 -SKPAAPQVPPKKPTPPTKASNLLRSSGTVYPKRPEKPVPPPPPIAKINGEVSSISSKFE 438

Query: 390 -GPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPK 448
             P++  + DS ++ L   S+    D      S + D+  FD + SS E L H T +RPK
Sbjct: 439 TEPVSKLKLDSEQLPLRPKSVD--FDSLTVRTSKETDVVNFDDIASS-ENLLHLTANRPK 495

Query: 449 ATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTISQVSDN 508
             GRR P +                SP    E+ + L      A+ K S+          
Sbjct: 496 MPGRRLPGR-----------FNGGHSPTHSPEKILKLPKEEDSANLKPSEL-------KK 537

Query: 509 KASLPPKPGTMAAGGGGPAPLSSAAPSPLSSSLGTAGHRANSPSLFGTEGKPKMEPAASS 568
                PKP               + PS  S +  TA        L   E K K+E     
Sbjct: 538 DTCYSPKPSVYL-----------STPSSASKANTTA-------FLTPLEIKAKVETDDVK 579

Query: 569 QAAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKKALQS 627
           + +++ELR Q+ EL  I+E +K    +E+++L  +L+EEK +R  L+ME+  +KKA+ S
Sbjct: 580 KNSLDELRAQIIELLCIVEALKKDHGKELEKLRKDLEEEKTMRSNLEMEIEKLKKAVLS 638



 Score =  105 bits (262), Expect = 1e-22
 Identities = 93/303 (30%), Positives = 130/303 (42%), Gaps = 80/303 (26%)

Query: 68  VAFSYLPQNDDELELKVGDIIEVVGEV-EEGWWEGVLNGKTGMFPSNFIKELSGESDELG 126
           V + Y   +DDEL ++VG+II  V ++ EEGW EG LNG+ GMFP NF+KE+  E++   
Sbjct: 6   VEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETE--- 62

Query: 127 ISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKP 186
             +D+ L     RE  G+ +      ST    A G      IQP                
Sbjct: 63  -FKDDSLPIK--RERHGNVASLVQRISTYGLPAGG------IQPH--------------- 98

Query: 187 IKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQND 246
                          P  K I KK                     K  CKV+F Y  QN+
Sbjct: 99  ---------------PQTKNIKKK-------------------TKKRQCKVLFEYIPQNE 124

Query: 247 DELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNR------- 299
           DEL +K GDI+  IN++ ++ GWW G LN + G+FP NFVK L    + E +        
Sbjct: 125 DELELKVGDIID-INEE-VEEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDSET 182

Query: 300 ----PKKPPPPSAPVIKQGAGTTERKHEIKKIP-----PERPEMLPNRTEEKERPEREPK 350
               P  P P    V +  +G+  +  +I+ I       E    L  RT   E  E++P+
Sbjct: 183 VLAGPTSPIPSLGNVSETASGSVTQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKPE 242

Query: 351 LDL 353
             L
Sbjct: 243 KPL 245



 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 37/106 (34%), Positives = 57/106 (53%), Gaps = 4/106 (3%)

Query: 17  IEIKKEMKKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGE-RRRRRCQVAFSYLPQ 75
           ++++          K PEKPL     G    S E I +T+  G+ + +  C+  F+Y   
Sbjct: 225 VKLRTRTSSSETEEKKPEKPLILQSLGPKTQSVE-ITKTDTEGKIKAKEYCRTLFAYEGT 283

Query: 76  NDDELELKVGDIIEVVGEV--EEGWWEGVLNGKTGMFPSNFIKELS 119
           N+DEL  K G+II ++ +   E GWW G LNGK G+FP NF  +++
Sbjct: 284 NEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQIN 329


>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
          Length = 1220

 Score = 86.7 bits (213), Expect = 6e-17
 Identities = 63/221 (28%), Positives = 100/221 (45%), Gaps = 22/221 (9%)

Query: 70   FSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQ 129
            ++Y      +L  + GD+I +V + +  WW G +  K G+FPSN+++    E        
Sbjct: 1011 YTYESSEQGDLTFQQGDVI-LVTKKDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKT 1069

Query: 130  DEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKL 189
                 K  + +   S +  G    T + G         I+ K   G   G+        L
Sbjct: 1070 GSLGKKPEIAQVIASYTATGPEQLTLAPG-----QLILIRKKNPGGWWEGE--------L 1116

Query: 190  RPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVI--FPYEAQNDD 247
            + R  + +  + P       KL  +  T   + TE    T     C+VI  + Y AQNDD
Sbjct: 1117 QARGKKRQIGWFPANYV---KL-LSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDD 1172

Query: 248  ELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKL 288
            EL   +G I+ ++NK+  D  WW+GE+NG+ G+FP N+VKL
Sbjct: 1173 ELAFNKGQIINVLNKE--DPDWWKGEVNGQVGLFPSNYVKL 1211



 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 69/264 (26%), Positives = 114/264 (43%), Gaps = 47/264 (17%)

Query: 65   RCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDE 124
            + Q  + +  + D+ L     D+I V+ E ++ WW G + G+ G FP +++K +SG    
Sbjct: 917  QAQALYPWRAKKDNHLNFNKNDVITVL-EQQDMWWFGEVQGQKGWFPKSYVKLISGP--- 972

Query: 125  LGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKD 184
                         +R++T       DS S++S  +   VA+ A +P  V G  F  ++  
Sbjct: 973  -------------IRKSTSM-----DSGSSESPASLKRVASPAAKPV-VSGEEFIAMYTY 1013

Query: 185  KPIKLRPRSIEVENDFLPVEK-------TIGKKLPATTATPDSSKTEMDSRTKSK----- 232
            +  +    + +  +  L  +K       T+G K     +     K    S T  K     
Sbjct: 1014 ESSEQGDLTFQQGDVILVTKKDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLG 1073

Query: 233  ---DYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRR-----GVFPDN 284
               +  +VI  Y A   ++LT+  G ++ +  K+    GWWEGEL  R      G FP N
Sbjct: 1074 KKPEIAQVIASYTATGPEQLTLAPGQLILIRKKN--PGGWWEGELQARGKKRQIGWFPAN 1131

Query: 285  FVKLLPPDFEKEGNRPKKPPPPSA 308
            +VKLL P   K    P +PP  +A
Sbjct: 1132 YVKLLSPGTSK--ITPTEPPKSTA 1153



 Score = 70.1 bits (170), Expect = 6e-12
 Identities = 57/241 (23%), Positives = 101/241 (41%), Gaps = 29/241 (12%)

Query: 70  FSYLPQNDDELELKVGDIIEVVGEV-------EEGWWEGVLNGKTGMFPSNFIKELSGES 122
           + +  ++ DE+ ++ GDI+ V GE        E GW  G L GKTG FP+N+ +++    
Sbjct: 749 YPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPENE 808

Query: 123 DELGI-----SQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVG 177
               +     S      K +LRET    +      ST         +T      +     
Sbjct: 809 VPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPNNWADFSSTWPTSTNEKPETD 868

Query: 178 FGDIFKDKPIKLRPRS--IEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDY- 234
             D +  +P    P +  +   + F P            TAT  S    +    K +   
Sbjct: 869 NWDAWAAQPSLTVPSAGQLRQRSAFTPA-----------TATGSSPSPVLGQGEKVEGLQ 917

Query: 235 CKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFE 294
            + ++P+ A+ D+ L   + D++T++ +  +   WW GE+ G++G FP ++VKL+     
Sbjct: 918 AQALYPWRAKKDNHLNFNKNDVITVLEQQDM---WWFGEVQGQKGWFPKSYVKLISGPIR 974

Query: 295 K 295
           K
Sbjct: 975 K 975



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 25/53 (47%), Positives = 35/53 (66%), Gaps = 2/53 (3%)

Query: 66   CQVA--FSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIK 116
            CQV   + Y  QNDDEL    G II V+ + +  WW+G +NG+ G+FPSN++K
Sbjct: 1158 CQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVK 1210



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 47/167 (28%), Positives = 71/167 (42%), Gaps = 30/167 (17%)

Query: 234 YCKVIFPYEAQNDDELTIKEGDIVTLINKDCID------VGWWEGELNGRRGVFPDNFVK 287
           Y + ++P+E+++ DE+TI+ GDIV ++  + +D       GW  GEL G+ G FP N+ +
Sbjct: 744 YYRALYPFESRSHDEITIQPGDIV-MVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAE 802

Query: 288 LLPPDFEKEGNRPKKP--PPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNR------- 338
            +P   E E   P KP     SAP  K     T        +    P   PN        
Sbjct: 803 KIP---ENEVPAPVKPVTDSTSAPAPKLALRETPAP---LAVTSSEPSTTPNNWADFSST 856

Query: 339 --TEEKERPERE------PKLDLQKPSVPAIPPKKPRPPKTNSLSRP 377
             T   E+PE +       +  L  PS   +  +    P T + S P
Sbjct: 857 WPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSP 903


>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
          Length = 1721

 Score = 86.7 bits (213), Expect = 6e-17
 Identities = 63/221 (28%), Positives = 100/221 (45%), Gaps = 22/221 (9%)

Query: 70   FSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQ 129
            ++Y      +L  + GD+I +V + +  WW G +  K G+FPSN+++    E        
Sbjct: 1011 YTYESSEQGDLTFQQGDVI-LVTKKDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKT 1069

Query: 130  DEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKL 189
                 K  + +   S +  G    T + G         I+ K   G   G+        L
Sbjct: 1070 GSLGKKPEIAQVIASYTATGPEQLTLAPG-----QLILIRKKNPGGWWEGE--------L 1116

Query: 190  RPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVI--FPYEAQNDD 247
            + R  + +  + P       KL  +  T   + TE    T     C+VI  + Y AQNDD
Sbjct: 1117 QARGKKRQIGWFPANYV---KL-LSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDD 1172

Query: 248  ELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKL 288
            EL   +G I+ ++NK+  D  WW+GE+NG+ G+FP N+VKL
Sbjct: 1173 ELAFNKGQIINVLNKE--DPDWWKGEVNGQVGLFPSNYVKL 1211



 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 69/264 (26%), Positives = 114/264 (43%), Gaps = 47/264 (17%)

Query: 65   RCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDE 124
            + Q  + +  + D+ L     D+I V+ E ++ WW G + G+ G FP +++K +SG    
Sbjct: 917  QAQALYPWRAKKDNHLNFNKNDVITVL-EQQDMWWFGEVQGQKGWFPKSYVKLISGP--- 972

Query: 125  LGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKD 184
                         +R++T       DS S++S  +   VA+ A +P  V G  F  ++  
Sbjct: 973  -------------IRKSTSM-----DSGSSESPASLKRVASPAAKPV-VSGEEFIAMYTY 1013

Query: 185  KPIKLRPRSIEVENDFLPVEK-------TIGKKLPATTATPDSSKTEMDSRTKSK----- 232
            +  +    + +  +  L  +K       T+G K     +     K    S T  K     
Sbjct: 1014 ESSEQGDLTFQQGDVILVTKKDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLG 1073

Query: 233  ---DYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRR-----GVFPDN 284
               +  +VI  Y A   ++LT+  G ++ +  K+    GWWEGEL  R      G FP N
Sbjct: 1074 KKPEIAQVIASYTATGPEQLTLAPGQLILIRKKN--PGGWWEGELQARGKKRQIGWFPAN 1131

Query: 285  FVKLLPPDFEKEGNRPKKPPPPSA 308
            +VKLL P   K    P +PP  +A
Sbjct: 1132 YVKLLSPGTSK--ITPTEPPKSTA 1153



 Score = 70.1 bits (170), Expect = 6e-12
 Identities = 57/241 (23%), Positives = 101/241 (41%), Gaps = 29/241 (12%)

Query: 70  FSYLPQNDDELELKVGDIIEVVGEV-------EEGWWEGVLNGKTGMFPSNFIKELSGES 122
           + +  ++ DE+ ++ GDI+ V GE        E GW  G L GKTG FP+N+ +++    
Sbjct: 749 YPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPENE 808

Query: 123 DELGI-----SQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVG 177
               +     S      K +LRET    +      ST         +T      +     
Sbjct: 809 VPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPNNWADFSSTWPTSTNEKPETD 868

Query: 178 FGDIFKDKPIKLRPRS--IEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDY- 234
             D +  +P    P +  +   + F P            TAT  S    +    K +   
Sbjct: 869 NWDAWAAQPSLTVPSAGQLRQRSAFTPA-----------TATGSSPSPVLGQGEKVEGLQ 917

Query: 235 CKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFE 294
            + ++P+ A+ D+ L   + D++T++ +  +   WW GE+ G++G FP ++VKL+     
Sbjct: 918 AQALYPWRAKKDNHLNFNKNDVITVLEQQDM---WWFGEVQGQKGWFPKSYVKLISGPIR 974

Query: 295 K 295
           K
Sbjct: 975 K 975



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 25/53 (47%), Positives = 35/53 (66%), Gaps = 2/53 (3%)

Query: 66   CQVA--FSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIK 116
            CQV   + Y  QNDDEL    G II V+ + +  WW+G +NG+ G+FPSN++K
Sbjct: 1158 CQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVK 1210



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 47/167 (28%), Positives = 71/167 (42%), Gaps = 30/167 (17%)

Query: 234 YCKVIFPYEAQNDDELTIKEGDIVTLINKDCID------VGWWEGELNGRRGVFPDNFVK 287
           Y + ++P+E+++ DE+TI+ GDIV ++  + +D       GW  GEL G+ G FP N+ +
Sbjct: 744 YYRALYPFESRSHDEITIQPGDIV-MVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAE 802

Query: 288 LLPPDFEKEGNRPKKP--PPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNR------- 338
            +P   E E   P KP     SAP  K     T        +    P   PN        
Sbjct: 803 KIP---ENEVPAPVKPVTDSTSAPAPKLALRETPAP---LAVTSSEPSTTPNNWADFSST 856

Query: 339 --TEEKERPERE------PKLDLQKPSVPAIPPKKPRPPKTNSLSRP 377
             T   E+PE +       +  L  PS   +  +    P T + S P
Sbjct: 857 WPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSP 903


>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
           sapiens]
          Length = 756

 Score = 82.8 bits (203), Expect = 9e-16
 Identities = 164/730 (22%), Positives = 252/730 (34%), Gaps = 186/730 (25%)

Query: 33  PEKPLHEVPSGNSLLSSETILR---TNKRGE-----RRRRRCQVAFSYLPQNDDELELKV 84
           PE+ + E+P   +L  S    R     +RG      R +R C+V FSY P+  DEL+L+ 
Sbjct: 49  PERLVQEIPE--TLRGSGEARRPRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQA 106

Query: 85  GDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELG------------------ 126
           G+I+E++ E+E+GWW G  NG+ G FPSNF++ L      LG                  
Sbjct: 107 GEIVEMIKEIEDGWWLGKKNGQLGAFPSNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLS 166

Query: 127 ----ISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGD-- 180
                S  + L   S  E      D    +  +     G V     +  + KG   G+  
Sbjct: 167 SLAYDSPPDYLQTVSHPEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQ 226

Query: 181 ----IFKDK------PI-KLRPRSIEVENDFLPVEK----------TIGKKLPATTATPD 219
               +F D       PI KL PR + V  +  P+++             KKL   T  P 
Sbjct: 227 GRRGVFPDNFVLPPPPIKKLVPRKV-VSRESAPIKEPKKLMPKTSLPTVKKLATATTGPS 285

Query: 220 SSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELN---G 276
            +KT   SRT S+D  K                      L ++D    G ++   +   G
Sbjct: 286 KAKT---SRTPSRDSQK----------------------LTSRDSGPNGGFQSGGSYHPG 320

Query: 277 RRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLP 336
           R+        +      E+E + P K P      +     T ER    +  P  +    P
Sbjct: 321 RKRSKTQTPQQRSVSSQEEEHSSPVKAPSVKRTPMPDKTATPERPPAPENAPSSKKIPAP 380

Query: 337 NRTEEKERPEREPKLDL-QKPSVPA--------IPPKKPRPPKTNSLSRPGALP------ 381
           ++      P  E  L L  K S+P          P K P P K  +     ++P      
Sbjct: 381 DKV-----PSPEKTLTLGDKASIPGNSTSGKIPAPDKVPTPEKMVTPEDKASIPENSIIP 435

Query: 382 --------PRRPERPVGPLTHTRGDSPKIDLA-----------GSSLSGILDKDLSDRS- 421
                   P  PER          ++P +D               +L  +L  +LS+   
Sbjct: 436 EETLTVDKPSTPERVFSVEESPALEAPPMDKVPNPKMAPLGDEAPTLEKVLTPELSEEEV 495

Query: 422 ---NDIDLEGFDS---------VVSSTEKLSHPTTSRPKATGRRPPS------------- 456
              +DI    F S          V+  +  S      P+A   +PPS             
Sbjct: 496 STRDDIQFHHFSSEEALQKVKYFVAKEDPSSQEEAHTPEAPPPQPPSSERCLGEMKCTLV 555

Query: 457 -------QSLTSSSLSSPDIFDSPSPEED----------------KEEHISLAHRGVDAS 493
                  Q+   S  +S    + P P E+                +EE      R +   
Sbjct: 556 RGDSSPRQAELKSGPASRPALEKPHPHEEATTLPEEAPSNDERTPEEEAPPNEQRPLREE 615

Query: 494 KKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLSSSLGTAGHRANSPSL 553
               + V   +    K  LPPK           AP     P   + +  T   +   P  
Sbjct: 616 VLPKEGVASKEEVTLKEELPPKEEV--------APKEEVPPIERAFAQKTRPIKP-PPDS 666

Query: 554 FGTEGKPKMEPAASSQ-----AAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDEEK 608
             T   P + P   ++       V  LR +V  LR  +E M+ Q +R++  +  EL  EK
Sbjct: 667 QETLALPSLVPQNYTENKNEGVDVTSLRGEVESLRRALELMEVQLERKLTDIWEELKSEK 726

Query: 609 KIRLRLQMEV 618
           + R RL+++V
Sbjct: 727 EQRRRLEVQV 736



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 43/166 (25%), Positives = 69/166 (41%), Gaps = 28/166 (16%)

Query: 237 VIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLP------ 290
           V+  Y AQ +DEL++  GD+V  + +     GW  GE  GR G+FP+  V+ +P      
Sbjct: 5   VLAGYRAQKEDELSLAPGDVVRQV-RWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGS 63

Query: 291 -----PDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERP 345
                P   +    P K P P        + + E+  E+K    E  EM+    +     
Sbjct: 64  GEARRPRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLG 123

Query: 346 EREPKL----------------DLQKPSVPAIPPKKPRPPKTNSLS 375
           ++  +L                 L  P +P++ P   RPPK +SL+
Sbjct: 124 KKNGQLGAFPSNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLA 169



 Score = 39.7 bits (91), Expect = 0.008
 Identities = 19/52 (36%), Positives = 27/52 (51%), Gaps = 1/52 (1%)

Query: 68  VAFSYLPQNDDELELKVGDIIEVVGEVE-EGWWEGVLNGKTGMFPSNFIKEL 118
           V   Y  Q +DEL L  GD++  V  V   GW  G   G+ G+FP   ++E+
Sbjct: 5   VLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEI 56


>gi|242117948 SH3 domain-containing protein C1orf113 isoform 2 [Homo
           sapiens]
          Length = 645

 Score = 82.8 bits (203), Expect = 9e-16
 Identities = 92/330 (27%), Positives = 135/330 (40%), Gaps = 74/330 (22%)

Query: 236 KVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEK 295
           +V+F Y+ +  DEL ++ GD+V +++K   D GWWEGE  GRRGVFPDNFV L PP  +K
Sbjct: 76  RVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFV-LPPPPIKK 134

Query: 296 EGNR------------PKK-PPPPSAPVIKQ--GAGTTERKHEIKKIPPERPEML----- 335
              R            PKK  P  S P +K+   A T   K +  + P    + L     
Sbjct: 135 LVPRKVVSRESAPIKEPKKLMPKTSLPTVKKLATATTGPSKAKTSRTPSRDSQKLTSRDS 194

Query: 336 -------------PNRTEEKERPEREPKLDLQKP--SVPAIPP---KKPRPPKTNSLSRP 377
                        P R   K +  ++  +  Q+   S P   P   + P P KT +  RP
Sbjct: 195 GPNGGFQSGGSYHPGRKRSKTQTPQQRSVSSQEEEHSSPVKAPSVKRTPMPDKTATPERP 254

Query: 378 GALPPRRPER---------PVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEG 428
            A P   P           P    T T GD  K  + G+S SG +               
Sbjct: 255 PA-PENAPSSKKIPAPDKVPSPEKTLTLGD--KASIPGNSTSGKIPA------------- 298

Query: 429 FDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPD----IFDSP---SPEEDKEE 481
               V + EK+  P            P ++LT    S+P+    + +SP   +P  DK  
Sbjct: 299 -PDKVPTPEKMVTPEDKASIPENSIIPEETLTVDKPSTPERVFSVEESPALEAPPMDKVP 357

Query: 482 HISLAHRGVDASKKTSKTVTISQVSDNKAS 511
           +  +A  G +A   T + V   ++S+ + S
Sbjct: 358 NPKMAPLGDEA--PTLEKVLTPELSEEEVS 385



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 136/612 (22%), Positives = 219/612 (35%), Gaps = 122/612 (19%)

Query: 67  QVAFSYLPQNDDELELKVGDIIEVVGEVEE--GWWEGVLNGKTGMFPSNFI--------- 115
           +V F Y P+  DEL L+ GD+++V+ +  E  GWWEG   G+ G+FP NF+         
Sbjct: 76  RVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFVLPPPPIKKL 135

Query: 116 ---KELSGESDELGISQDEQLSKSSL-------RETTG------SESDGGDSS--STKSE 157
              K +S ES  +     + + K+SL         TTG      S +   DS   +++  
Sbjct: 136 VPRKVVSRESAPIK-EPKKLMPKTSLPTVKKLATATTGPSKAKTSRTPSRDSQKLTSRDS 194

Query: 158 GANGTVAT----------AAIQPKKVKGVGFGDIFKDKPIK--------LRPRSIEVEND 199
           G NG   +          +  Q  + + V   +     P+K        +  ++   E  
Sbjct: 195 GPNGGFQSGGSYHPGRKRSKTQTPQQRSVSSQEEEHSSPVKAPSVKRTPMPDKTATPERP 254

Query: 200 FLPVEKTIGKKLPATTATPDSSKT----EMDSRTKSKDYCKVIFPYEAQNDDELTIKEGD 255
             P      KK+PA    P   KT    +  S   +    K+  P +    +++   E D
Sbjct: 255 PAPENAPSSKKIPAPDKVPSPEKTLTLGDKASIPGNSTSGKIPAPDKVPTPEKMVTPE-D 313

Query: 256 IVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGA 315
             ++     I     E  L   +   P+    +      +     K P P  AP +   A
Sbjct: 314 KASIPENSIIP----EETLTVDKPSTPERVFSVEESPALEAPPMDKVPNPKMAP-LGDEA 368

Query: 316 GTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLS 375
            T E     K + PE  E   +  ++ +      +  LQK         K  P       
Sbjct: 369 PTLE-----KVLTPELSEEEVSTRDDIQFHHFSSEEALQKVKYFV---AKEDPSSQEEAH 420

Query: 376 RPGALPPRRP--ERPVGPL--THTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDS 431
            P A PP+ P  ER +G +  T  RGDS                  S R  ++       
Sbjct: 421 TPEAPPPQPPSSERCLGEMKCTLVRGDS------------------SPRQAEL------- 455

Query: 432 VVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGVD 491
               +   S P   +P       P +  T+    +P   D  +PEE+   +     R + 
Sbjct: 456 ---KSGPASRPALEKPH------PHEEATTLPEEAPS-NDERTPEEEAPPN---EQRPLR 502

Query: 492 ASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLSSSLGTAGHRANSP 551
                 + V   +    K  LPPK           AP     P   + +  T   +   P
Sbjct: 503 EEVLPKEGVASKEEVTLKEELPPKEEV--------APKEEVPPIERAFAQKTRPIKP-PP 553

Query: 552 SLFGTEGKPKMEPAASSQ-----AAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDE 606
               T   P + P   ++       V  LR +V  LR  +E M+ Q +R++  +  EL  
Sbjct: 554 DSQETLALPSLVPQNYTENKNEGVDVTSLRGEVESLRRALELMEVQLERKLTDIWEELKS 613

Query: 607 EKKIRLRLQMEV 618
           EK+ R RL+++V
Sbjct: 614 EKEQRRRLEVQV 625



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 88/360 (24%), Positives = 129/360 (35%), Gaps = 76/360 (21%)

Query: 265 IDVGWWEGELNGRRGVFPDNFVKLLP--------PDFEKEGNRPKKPPP------PSAPV 310
           I+ GWW G+ NG+ G FP NFV+LL         PD       P++PP        S P 
Sbjct: 5   IEDGWWLGKKNGQLGAFPSNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPD 64

Query: 311 IKQGAGTTERKHEIKKIPPERPE-----------MLPNRTEEKERPERE---------PK 350
             Q     E    +    PE P+           +L   TE+K   E E           
Sbjct: 65  YLQTVSHPEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDN 124

Query: 351 LDLQKPSVPAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPL-THTRGDSPKIDLAGSSL 409
             L  P +  + P+K    ++  +  P  L P+     V  L T T G S     A +S 
Sbjct: 125 FVLPPPPIKKLVPRKVVSRESAPIKEPKKLMPKTSLPTVKKLATATTGPSK----AKTSR 180

Query: 410 SGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLT------SSS 463
           +   D       +     GF S  S      HP   R K   + P  +S++      SS 
Sbjct: 181 TPSRDSQKLTSRDSGPNGGFQSGGS-----YHPGRKRSKT--QTPQQRSVSSQEEEHSSP 233

Query: 464 LSSPDIFDSPSPEEDKEEHISLAHRGVDASKK---------TSKTVTISQVSDNKASLP- 513
           + +P +  +P P++        A     +SKK           KT+T+     +KAS+P 
Sbjct: 234 VKAPSVKRTPMPDKTATPERPPAPENAPSSKKIPAPDKVPSPEKTLTLG----DKASIPG 289

Query: 514 -PKPGTMAAGGGGPAPLSSAAPS-----PLSSSLGTAGHRANSPS----LFGTEGKPKME 563
               G + A    P P     P      P +S +       + PS    +F  E  P +E
Sbjct: 290 NSTSGKIPAPDKVPTPEKMVTPEDKASIPENSIIPEETLTVDKPSTPERVFSVEESPALE 349


>gi|39930351 dynamin binding protein [Homo sapiens]
          Length = 1577

 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 64/222 (28%), Positives = 94/222 (42%), Gaps = 28/222 (12%)

Query: 70  FSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQ 129
           F + P   +EL L VGDIIEV+  V+E W  G     TG FPS+F++ ++  S    + +
Sbjct: 11  FDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVTIPS----LKE 66

Query: 130 DEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKL 189
            E+L    + E T  E D            +G      +Q +   G              
Sbjct: 67  GERLFVC-ICEFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGA------------- 112

Query: 190 RPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDEL 249
                     F P        L + +    S          S    + +    AQ D+EL
Sbjct: 113 --------RGFFPSSCVRELCLSSQSRQWHSQSALFQIPEYSMGQARALMGLSAQLDEEL 164

Query: 250 TIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPP 291
             +EGD++T+I     + GW+EGEL GRRG+FP+ FV+LL P
Sbjct: 165 DFREGDVITIIGVP--EPGWFEGELEGRRGIFPEGFVELLGP 204



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 67/268 (25%), Positives = 103/268 (38%), Gaps = 81/268 (30%)

Query: 75  QNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLS 134
           Q D+EL+ + GD+I ++G  E GW+EG L G+ G+FP  F++ L                
Sbjct: 159 QLDEELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFVELLG--------------- 203

Query: 135 KSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSI 194
              LR    S S G           NG V                    D P+       
Sbjct: 204 --PLRTVDESVSSGNQDDCI----VNGEV--------------------DTPVG------ 231

Query: 195 EVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEG 254
                    E+ IG         PD  + E  +      Y   ++ ++A   +EL  + G
Sbjct: 232 ---------EEEIG---------PDEDEEEPGT------YGVALYRFQALEPNELDFEVG 267

Query: 255 DIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPD-------FEKEGNRPKKPPPPS 307
           D + ++    ++ GW EG L GR G+FP  FVKL P           +EG+   + P  S
Sbjct: 268 DKIRILAT--LEDGWLEGSLKGRTGIFPYRFVKLCPDTRVEETMALPQEGSL-ARIPETS 324

Query: 308 APVIKQGAGTTERKHEIKKIPPERPEML 335
              ++   G  E++HE      E P+ +
Sbjct: 325 LDCLENTLGVEEQRHETSDHEAEEPDCI 352



 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 30/101 (29%), Positives = 51/101 (50%), Gaps = 8/101 (7%)

Query: 78  DELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIK--------ELSGESDELGISQ 129
           +EL+ +VGD I ++  +E+GW EG L G+TG+FP  F+K        E      E  +++
Sbjct: 260 NELDFEVGDKIRILATLEDGWLEGSLKGRTGIFPYRFVKLCPDTRVEETMALPQEGSLAR 319

Query: 130 DEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQP 170
             + S   L  T G E    ++S  ++E  +  ++ A   P
Sbjct: 320 IPETSLDCLENTLGVEEQRHETSDHEAEEPDCIISEAPTSP 360



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 20/77 (25%), Positives = 40/77 (51%), Gaps = 3/77 (3%)

Query: 214  TTATPDSSKTEMD-SRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLIN-KDCI-DVGWW 270
            T   P+   TE D S  +       ++ ++A+N +EL++     + ++  KD   +  WW
Sbjct: 1496 TAQAPEDRSTEPDGSEAEGNQVYFAVYTFKARNPNELSVSANQKLKILEFKDVTGNTEWW 1555

Query: 271  EGELNGRRGVFPDNFVK 287
              E+NG++G  P N+++
Sbjct: 1556 LAEVNGKKGYVPSNYIR 1572



 Score = 35.4 bits (80), Expect = 0.16
 Identities = 18/54 (33%), Positives = 31/54 (57%), Gaps = 8/54 (14%)

Query: 70   FSYLPQNDDEL------ELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKE 117
            +++  +N +EL      +LK+ +  +V G  E  WW   +NGK G  PSN+I++
Sbjct: 1522 YTFKARNPNELSVSANQKLKILEFKDVTGNTE--WWLAEVNGKKGYVPSNYIRK 1573



 Score = 32.0 bits (71), Expect = 1.8
 Identities = 19/64 (29%), Positives = 32/64 (50%), Gaps = 2/64 (3%)

Query: 236 KVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEK 295
           + IF +     +EL +  GDI+ ++    +D  W  G+     G FP +FV+++     K
Sbjct: 8   RAIFDFCPSVSEELPLFVGDIIEVLA--VVDEFWLLGKKEDVTGQFPSSFVEIVTIPSLK 65

Query: 296 EGNR 299
           EG R
Sbjct: 66  EGER 69


>gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo
           sapiens]
          Length = 816

 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 72/281 (25%), Positives = 129/281 (45%), Gaps = 31/281 (11%)

Query: 29  TNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDII 88
           + K  E P H +P+ + L S+E  +R  +  ++  R  +  F +  Q   EL L+ GDI+
Sbjct: 545 STKDSESPRHFIPA-DYLESTEEFIR-RRHDDKEMRPARAKFDFKAQTLKELPLQKGDIV 602

Query: 89  EVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSESDG 148
            +  ++++ W+EG  +G+ G+FP  +I EL   +++    +   +      E     +  
Sbjct: 603 YIYKQIDQNWYEGEHHGRVGIFPRTYI-ELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFN 661

Query: 149 GDSSSTKS--EGANGTVATAAIQ---PKKVKGVGFGDIFKDKPIKLRPRSIEVEN--DFL 201
           GD+    S  +G   T+     +     ++ G     IF    + +  R + V+N  D++
Sbjct: 662 GDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPL-VKNPVDYM 720

Query: 202 PVEKTIGKKLPATTA-----------TPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELT 250
            +  +      AT +           TPD S+T  D  +      + ++ Y  QNDDEL 
Sbjct: 721 DLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFS-----YQALYSYIPQNDDELE 775

Query: 251 IKEGDIVTLINKDCIDVGWWEGELNGRR--GVFPDNFVKLL 289
           +++GDIV ++ K   D GW+ G     +  G FP N+VK L
Sbjct: 776 LRDGDIVDVMEK--CDDGWFVGTSRRTKQFGTFPGNYVKPL 814



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 35/109 (32%), Positives = 58/109 (53%), Gaps = 11/109 (10%)

Query: 19  IKKEMKKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRC-------QVAFS 71
           IK+ + K+P+     + P    PS ++  S +      +R    R +        Q  +S
Sbjct: 708 IKRPLVKNPVDYM--DLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYS 765

Query: 72  YLPQNDDELELKVGDIIEVVGEVEEGWWEGV--LNGKTGMFPSNFIKEL 118
           Y+PQNDDELEL+ GDI++V+ + ++GW+ G      + G FP N++K L
Sbjct: 766 YIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 814



 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 40/127 (31%), Positives = 65/127 (51%), Gaps = 22/127 (17%)

Query: 196 VENDFLPVEKTIGKKLPATTATPDSSK-------------TEMDSRTKSKDY----CKVI 238
           +E   +P++   G K P+++A+   S+             TE   R +  D      +  
Sbjct: 524 LEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEMRPARAK 583

Query: 239 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGN 298
           F ++AQ   EL +++GDIV +  +  ID  W+EGE +GR G+FP  +++LLPP    E  
Sbjct: 584 FDFKAQTLKELPLQKGDIVYIYKQ--IDQNWYEGEHHGRVGIFPRTYIELLPP---AEKA 638

Query: 299 RPKKPPP 305
           +PKK  P
Sbjct: 639 QPKKLTP 645


>gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo
           sapiens]
          Length = 684

 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 72/281 (25%), Positives = 129/281 (45%), Gaps = 31/281 (11%)

Query: 29  TNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDII 88
           + K  E P H +P+ + L S+E  +R  +  ++  R  +  F +  Q   EL L+ GDI+
Sbjct: 413 STKDSESPRHFIPA-DYLESTEEFIR-RRHDDKEMRPARAKFDFKAQTLKELPLQKGDIV 470

Query: 89  EVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSESDG 148
            +  ++++ W+EG  +G+ G+FP  +I EL   +++    +   +      E     +  
Sbjct: 471 YIYKQIDQNWYEGEHHGRVGIFPRTYI-ELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFN 529

Query: 149 GDSSSTKS--EGANGTVATAAIQ---PKKVKGVGFGDIFKDKPIKLRPRSIEVEN--DFL 201
           GD+    S  +G   T+     +     ++ G     IF    + +  R + V+N  D++
Sbjct: 530 GDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPL-VKNPVDYM 588

Query: 202 PVEKTIGKKLPATTA-----------TPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELT 250
            +  +      AT +           TPD S+T  D  +      + ++ Y  QNDDEL 
Sbjct: 589 DLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFS-----YQALYSYIPQNDDELE 643

Query: 251 IKEGDIVTLINKDCIDVGWWEGELNGRR--GVFPDNFVKLL 289
           +++GDIV ++ K   D GW+ G     +  G FP N+VK L
Sbjct: 644 LRDGDIVDVMEK--CDDGWFVGTSRRTKQFGTFPGNYVKPL 682



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 35/109 (32%), Positives = 58/109 (53%), Gaps = 11/109 (10%)

Query: 19  IKKEMKKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRC-------QVAFS 71
           IK+ + K+P+     + P    PS ++  S +      +R    R +        Q  +S
Sbjct: 576 IKRPLVKNPVDYM--DLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYS 633

Query: 72  YLPQNDDELELKVGDIIEVVGEVEEGWWEGV--LNGKTGMFPSNFIKEL 118
           Y+PQNDDELEL+ GDI++V+ + ++GW+ G      + G FP N++K L
Sbjct: 634 YIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 682



 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 40/127 (31%), Positives = 65/127 (51%), Gaps = 22/127 (17%)

Query: 196 VENDFLPVEKTIGKKLPATTATPDSSK-------------TEMDSRTKSKDY----CKVI 238
           +E   +P++   G K P+++A+   S+             TE   R +  D      +  
Sbjct: 392 LEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEMRPARAK 451

Query: 239 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGN 298
           F ++AQ   EL +++GDIV +  +  ID  W+EGE +GR G+FP  +++LLPP    E  
Sbjct: 452 FDFKAQTLKELPLQKGDIVYIYKQ--IDQNWYEGEHHGRVGIFPRTYIELLPP---AEKA 506

Query: 299 RPKKPPP 305
           +PKK  P
Sbjct: 507 QPKKLTP 513


>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
          Length = 1670

 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 58/223 (26%), Positives = 96/223 (43%), Gaps = 33/223 (14%)

Query: 70   FSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQ 129
            + Y      +L    G+ I +V + +  WW G +  ++G+FPSN++K    ES       
Sbjct: 963  YPYSSVEPGDLTFTEGEEI-LVTQKDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASKS 1021

Query: 130  DEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKL 189
                 K  + + T +    G    + + G         I  K   G   G+        L
Sbjct: 1022 GASNKKPEIAQVTSAYVASGSEQLSLAPGQ-----LILILKKNTSGWWQGE--------L 1068

Query: 190  RPRSIEVENDFLPVE--KTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVI--FPYEAQN 245
            + R  + +  + P    K +G    +  ATP                C+VI  + Y A N
Sbjct: 1069 QARGKKRQKGWFPASHVKLLGPS--SERATPAFHPV-----------CQVIAMYDYAANN 1115

Query: 246  DDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKL 288
            +DEL+  +G ++ ++NKD  D  WW+GE+NG  G+FP N+VK+
Sbjct: 1116 EDELSFSKGQLINVMNKD--DPDWWQGEINGVTGLFPSNYVKM 1156



 Score = 69.7 bits (169), Expect = 8e-12
 Identities = 61/247 (24%), Positives = 106/247 (42%), Gaps = 47/247 (19%)

Query: 55  TNKRGERRRRRCQVAFSYLP------QNDDELELKVGDIIEVVGEV--EEGWWEGVLNGK 106
           T K  E++R    V  +Y        +N DE+    GDII+V  +   E GW  G   G 
Sbjct: 718 TLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGN 777

Query: 107 TGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATA 166
            G FP N+++++    +E  +S      K +L   T S S    ++ST SE  +      
Sbjct: 778 FGWFPCNYVEKMPSSENEKAVSP-----KKALLPPTVSLS----ATSTSSEPLSSN---- 824

Query: 167 AIQPKKV---KGVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKT 223
             QP  V   + V F ++                N     +    + +   + +P   + 
Sbjct: 825 --QPASVTDYQNVSFSNL--------------TVNTSWQKKSAFTRTVSPGSVSPIHGQG 868

Query: 224 EMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPD 283
           ++    K++  C     + A+ D+ L   + DI+T++ +      WW GE++G RG FP 
Sbjct: 869 QVVENLKAQALCS----WTAKKDNHLNFSKHDIITVLEQQ---ENWWFGEVHGGRGWFPK 921

Query: 284 NFVKLLP 290
           ++VK++P
Sbjct: 922 SYVKIIP 928



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 56/241 (23%), Positives = 100/241 (41%), Gaps = 31/241 (12%)

Query: 65   RCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDE 124
            + Q   S+  + D+ L     DII V+ E +E WW G ++G  G FP +++K + G   E
Sbjct: 875  KAQALCSWTAKKDNHLNFSKHDIITVL-EQQENWWFGEVHGGRGWFPKSYVKIIPGS--E 931

Query: 125  LGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKD 184
            +   + E L  +  ++ T +    G+                A+ P      G     + 
Sbjct: 932  VKREEPEALYAAVNKKPTSAAYSVGEEY-------------IALYPYSSVEPGDLTFTEG 978

Query: 185  KPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDS-----SKTEMDSRTKSKDYCKVIF 239
            + I +  +  E     +     I    P+    P       S ++  +  K  +  +V  
Sbjct: 979  EEILVTQKDGEWWTGSIGDRSGI---FPSNYVKPKDQESFGSASKSGASNKKPEIAQVTS 1035

Query: 240  PYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGR-----RGVFPDNFVKLLPPDFE 294
             Y A   ++L++  G ++ ++ K+    GWW+GEL  R     +G FP + VKLL P  E
Sbjct: 1036 AYVASGSEQLSLAPGQLILILKKNTS--GWWQGELQARGKKRQKGWFPASHVKLLGPSSE 1093

Query: 295  K 295
            +
Sbjct: 1094 R 1094



 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 25/60 (41%), Positives = 39/60 (65%), Gaps = 3/60 (5%)

Query: 66   CQVA--FSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESD 123
            CQV   + Y   N+DEL    G +I V+ + +  WW+G +NG TG+FPSN++K ++ +SD
Sbjct: 1103 CQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVK-MTTDSD 1161



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 27/83 (32%), Positives = 44/83 (53%), Gaps = 2/83 (2%)

Query: 236 KVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEK 295
           + ++P+EA+N DE++   GDI+ +  K   + GW  G   G  G FP N+V+ +P    +
Sbjct: 736 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 795

Query: 296 EGNRPKKPPPPSAPVIKQGAGTT 318
           +   PKK   P  P +   A +T
Sbjct: 796 KAVSPKKALLP--PTVSLSATST 816


>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
          Length = 1697

 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 58/223 (26%), Positives = 96/223 (43%), Gaps = 33/223 (14%)

Query: 70   FSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQ 129
            + Y      +L    G+ I +V + +  WW G +  ++G+FPSN++K    ES       
Sbjct: 990  YPYSSVEPGDLTFTEGEEI-LVTQKDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASKS 1048

Query: 130  DEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKL 189
                 K  + + T +    G    + + G         I  K   G   G+        L
Sbjct: 1049 GASNKKPEIAQVTSAYVASGSEQLSLAPGQ-----LILILKKNTSGWWQGE--------L 1095

Query: 190  RPRSIEVENDFLPVE--KTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVI--FPYEAQN 245
            + R  + +  + P    K +G    +  ATP                C+VI  + Y A N
Sbjct: 1096 QARGKKRQKGWFPASHVKLLGPS--SERATPAFHPV-----------CQVIAMYDYAANN 1142

Query: 246  DDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKL 288
            +DEL+  +G ++ ++NKD  D  WW+GE+NG  G+FP N+VK+
Sbjct: 1143 EDELSFSKGQLINVMNKD--DPDWWQGEINGVTGLFPSNYVKM 1183



 Score = 69.7 bits (169), Expect = 8e-12
 Identities = 61/247 (24%), Positives = 106/247 (42%), Gaps = 47/247 (19%)

Query: 55  TNKRGERRRRRCQVAFSYLP------QNDDELELKVGDIIEVVGEV--EEGWWEGVLNGK 106
           T K  E++R    V  +Y        +N DE+    GDII+V  +   E GW  G   G 
Sbjct: 745 TLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGN 804

Query: 107 TGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATA 166
            G FP N+++++    +E  +S      K +L   T S S    ++ST SE  +      
Sbjct: 805 FGWFPCNYVEKMPSSENEKAVSP-----KKALLPPTVSLS----ATSTSSEPLSSN---- 851

Query: 167 AIQPKKV---KGVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKT 223
             QP  V   + V F ++                N     +    + +   + +P   + 
Sbjct: 852 --QPASVTDYQNVSFSNL--------------TVNTSWQKKSAFTRTVSPGSVSPIHGQG 895

Query: 224 EMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPD 283
           ++    K++  C     + A+ D+ L   + DI+T++ +      WW GE++G RG FP 
Sbjct: 896 QVVENLKAQALCS----WTAKKDNHLNFSKHDIITVLEQQ---ENWWFGEVHGGRGWFPK 948

Query: 284 NFVKLLP 290
           ++VK++P
Sbjct: 949 SYVKIIP 955



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 56/241 (23%), Positives = 100/241 (41%), Gaps = 31/241 (12%)

Query: 65   RCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDE 124
            + Q   S+  + D+ L     DII V+ E +E WW G ++G  G FP +++K + G   E
Sbjct: 902  KAQALCSWTAKKDNHLNFSKHDIITVL-EQQENWWFGEVHGGRGWFPKSYVKIIPGS--E 958

Query: 125  LGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKD 184
            +   + E L  +  ++ T +    G+                A+ P      G     + 
Sbjct: 959  VKREEPEALYAAVNKKPTSAAYSVGEEY-------------IALYPYSSVEPGDLTFTEG 1005

Query: 185  KPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDS-----SKTEMDSRTKSKDYCKVIF 239
            + I +  +  E     +     I    P+    P       S ++  +  K  +  +V  
Sbjct: 1006 EEILVTQKDGEWWTGSIGDRSGI---FPSNYVKPKDQESFGSASKSGASNKKPEIAQVTS 1062

Query: 240  PYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGR-----RGVFPDNFVKLLPPDFE 294
             Y A   ++L++  G ++ ++ K+    GWW+GEL  R     +G FP + VKLL P  E
Sbjct: 1063 AYVASGSEQLSLAPGQLILILKKNTS--GWWQGELQARGKKRQKGWFPASHVKLLGPSSE 1120

Query: 295  K 295
            +
Sbjct: 1121 R 1121



 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 25/60 (41%), Positives = 39/60 (65%), Gaps = 3/60 (5%)

Query: 66   CQVA--FSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESD 123
            CQV   + Y   N+DEL    G +I V+ + +  WW+G +NG TG+FPSN++K ++ +SD
Sbjct: 1130 CQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVK-MTTDSD 1188



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 27/83 (32%), Positives = 44/83 (53%), Gaps = 2/83 (2%)

Query: 236 KVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEK 295
           + ++P+EA+N DE++   GDI+ +  K   + GW  G   G  G FP N+V+ +P    +
Sbjct: 763 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 822

Query: 296 EGNRPKKPPPPSAPVIKQGAGTT 318
           +   PKK   P  P +   A +T
Sbjct: 823 KAVSPKKALLP--PTVSLSATST 843


>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
          Length = 1249

 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 58/223 (26%), Positives = 96/223 (43%), Gaps = 33/223 (14%)

Query: 70   FSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQ 129
            + Y      +L    G+ I +V + +  WW G +  ++G+FPSN++K    ES       
Sbjct: 990  YPYSSVEPGDLTFTEGEEI-LVTQKDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASKS 1048

Query: 130  DEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKL 189
                 K  + + T +    G    + + G         I  K   G   G+        L
Sbjct: 1049 GASNKKPEIAQVTSAYVASGSEQLSLAPGQ-----LILILKKNTSGWWQGE--------L 1095

Query: 190  RPRSIEVENDFLPVE--KTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVI--FPYEAQN 245
            + R  + +  + P    K +G    +  ATP                C+VI  + Y A N
Sbjct: 1096 QARGKKRQKGWFPASHVKLLGPS--SERATPAFHPV-----------CQVIAMYDYAANN 1142

Query: 246  DDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKL 288
            +DEL+  +G ++ ++NKD  D  WW+GE+NG  G+FP N+VK+
Sbjct: 1143 EDELSFSKGQLINVMNKD--DPDWWQGEINGVTGLFPSNYVKM 1183



 Score = 69.7 bits (169), Expect = 8e-12
 Identities = 61/247 (24%), Positives = 106/247 (42%), Gaps = 47/247 (19%)

Query: 55  TNKRGERRRRRCQVAFSYLP------QNDDELELKVGDIIEVVGEV--EEGWWEGVLNGK 106
           T K  E++R    V  +Y        +N DE+    GDII+V  +   E GW  G   G 
Sbjct: 745 TLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGN 804

Query: 107 TGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATA 166
            G FP N+++++    +E  +S      K +L   T S S    ++ST SE  +      
Sbjct: 805 FGWFPCNYVEKMPSSENEKAVSP-----KKALLPPTVSLS----ATSTSSEPLSSN---- 851

Query: 167 AIQPKKV---KGVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKT 223
             QP  V   + V F ++                N     +    + +   + +P   + 
Sbjct: 852 --QPASVTDYQNVSFSNL--------------TVNTSWQKKSAFTRTVSPGSVSPIHGQG 895

Query: 224 EMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPD 283
           ++    K++  C     + A+ D+ L   + DI+T++ +      WW GE++G RG FP 
Sbjct: 896 QVVENLKAQALCS----WTAKKDNHLNFSKHDIITVLEQQ---ENWWFGEVHGGRGWFPK 948

Query: 284 NFVKLLP 290
           ++VK++P
Sbjct: 949 SYVKIIP 955



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 56/241 (23%), Positives = 100/241 (41%), Gaps = 31/241 (12%)

Query: 65   RCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDE 124
            + Q   S+  + D+ L     DII V+ E +E WW G ++G  G FP +++K + G   E
Sbjct: 902  KAQALCSWTAKKDNHLNFSKHDIITVL-EQQENWWFGEVHGGRGWFPKSYVKIIPGS--E 958

Query: 125  LGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKD 184
            +   + E L  +  ++ T +    G+                A+ P      G     + 
Sbjct: 959  VKREEPEALYAAVNKKPTSAAYSVGEEY-------------IALYPYSSVEPGDLTFTEG 1005

Query: 185  KPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDS-----SKTEMDSRTKSKDYCKVIF 239
            + I +  +  E     +     I    P+    P       S ++  +  K  +  +V  
Sbjct: 1006 EEILVTQKDGEWWTGSIGDRSGI---FPSNYVKPKDQESFGSASKSGASNKKPEIAQVTS 1062

Query: 240  PYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGR-----RGVFPDNFVKLLPPDFE 294
             Y A   ++L++  G ++ ++ K+    GWW+GEL  R     +G FP + VKLL P  E
Sbjct: 1063 AYVASGSEQLSLAPGQLILILKKNTS--GWWQGELQARGKKRQKGWFPASHVKLLGPSSE 1120

Query: 295  K 295
            +
Sbjct: 1121 R 1121



 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 25/60 (41%), Positives = 39/60 (65%), Gaps = 3/60 (5%)

Query: 66   CQVA--FSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESD 123
            CQV   + Y   N+DEL    G +I V+ + +  WW+G +NG TG+FPSN++K ++ +SD
Sbjct: 1130 CQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVK-MTTDSD 1188



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 27/83 (32%), Positives = 44/83 (53%), Gaps = 2/83 (2%)

Query: 236 KVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEK 295
           + ++P+EA+N DE++   GDI+ +  K   + GW  G   G  G FP N+V+ +P    +
Sbjct: 763 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 822

Query: 296 EGNRPKKPPPPSAPVIKQGAGTT 318
           +   PKK   P  P +   A +T
Sbjct: 823 KAVSPKKALLP--PTVSLSATST 843


>gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo
           sapiens]
          Length = 905

 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 74/282 (26%), Positives = 119/282 (42%), Gaps = 47/282 (16%)

Query: 46  LLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNG 105
           LL+ +   +     E R  R +  F +  Q   EL L+ GDI+ +  ++++ W+EG  +G
Sbjct: 631 LLNIDDTAKRKSGSEMRPARAK--FDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHG 688

Query: 106 KTGMFPSNFIKELS------------------GES----DELGISQDEQLSKSSLRETTG 143
           + G+FP  +I+ L                   GE+    +  G +Q E   +   R T  
Sbjct: 689 RVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLL 748

Query: 144 SESDG----GDSSSTKSEGANGTVATAAIQPKKVKG-VGFGDI-FKDKPIK-------LR 190
            + D     G    T  +G         I+   VK  V + D+ F   P +       L 
Sbjct: 749 RQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLS 808

Query: 191 PRSIEVENDFLPVEKT-IGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDEL 249
             S+    D    EK+ +  +      TPD S+T  D  +      + ++ Y  QNDDEL
Sbjct: 809 HHSLRAGPDLTESEKSYVQPQAQQRRVTPDRSQTSQDLFSY-----QALYSYIPQNDDEL 863

Query: 250 TIKEGDIVTLINKDCIDVGWWEGELNGRR--GVFPDNFVKLL 289
            +++GDIV ++ K   D GW+ G     +  G FP N+VK L
Sbjct: 864 ELRDGDIVDVMEK--CDDGWFVGTSRRTKQFGTFPGNYVKPL 903



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 29/67 (43%), Positives = 43/67 (64%), Gaps = 5/67 (7%)

Query: 239 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGN 298
           F ++AQ   EL +++GDIV +  +  ID  W+EGE +GR G+FP  +++LLPP    E  
Sbjct: 653 FDFKAQTLKELPLQKGDIVYIYKQ--IDQNWYEGEHHGRVGIFPRTYIELLPP---AEKA 707

Query: 299 RPKKPPP 305
           +PKK  P
Sbjct: 708 QPKKLTP 714


>gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo
           sapiens]
          Length = 740

 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 67/264 (25%), Positives = 118/264 (44%), Gaps = 31/264 (11%)

Query: 46  LLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNG 105
           LL+ +   +     E R  R +  F +  Q   EL L+ GDI+ +  ++++ W+EG  +G
Sbjct: 486 LLNIDDTAKRKSGSEMRPARAK--FDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHG 543

Query: 106 KTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKS--EGANGTV 163
           + G+FP  +I EL   +++    +   +      E     +  GD+    S  +G   T+
Sbjct: 544 RVGIFPRTYI-ELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITL 602

Query: 164 ATAAIQ---PKKVKGVGFGDIFKDKPIKLRPRSIEVEN--DFLPVEKTIGKKLPATTA-- 216
                +     ++ G     IF    + +  R + V+N  D++ +  +      AT +  
Sbjct: 603 LRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPL-VKNPVDYMDLPFSSSPSRSATASPQ 661

Query: 217 ---------TPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDV 267
                    TPD S+T  D  +      + ++ Y  QNDDEL +++GDIV ++ K   D 
Sbjct: 662 QPQAQQRRVTPDRSQTSQDLFSY-----QALYSYIPQNDDELELRDGDIVDVMEK--CDD 714

Query: 268 GWWEGELNGRR--GVFPDNFVKLL 289
           GW+ G     +  G FP N+VK L
Sbjct: 715 GWFVGTSRRTKQFGTFPGNYVKPL 738



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 35/109 (32%), Positives = 58/109 (53%), Gaps = 11/109 (10%)

Query: 19  IKKEMKKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRC-------QVAFS 71
           IK+ + K+P+     + P    PS ++  S +      +R    R +        Q  +S
Sbjct: 632 IKRPLVKNPVDYM--DLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYS 689

Query: 72  YLPQNDDELELKVGDIIEVVGEVEEGWWEGV--LNGKTGMFPSNFIKEL 118
           Y+PQNDDELEL+ GDI++V+ + ++GW+ G      + G FP N++K L
Sbjct: 690 YIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 738



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 29/67 (43%), Positives = 43/67 (64%), Gaps = 5/67 (7%)

Query: 239 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGN 298
           F ++AQ   EL +++GDIV +  +  ID  W+EGE +GR G+FP  +++LLPP    E  
Sbjct: 508 FDFKAQTLKELPLQKGDIVYIYKQ--IDQNWYEGEHHGRVGIFPRTYIELLPP---AEKA 562

Query: 299 RPKKPPP 305
           +PKK  P
Sbjct: 563 QPKKLTP 569


>gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo
           sapiens]
          Length = 781

 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 67/264 (25%), Positives = 118/264 (44%), Gaps = 31/264 (11%)

Query: 46  LLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNG 105
           LL+ +   +     E R  R +  F +  Q   EL L+ GDI+ +  ++++ W+EG  +G
Sbjct: 527 LLNIDDTAKRKSGSEMRPARAK--FDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHG 584

Query: 106 KTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKS--EGANGTV 163
           + G+FP  +I EL   +++    +   +      E     +  GD+    S  +G   T+
Sbjct: 585 RVGIFPRTYI-ELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITL 643

Query: 164 ATAAIQ---PKKVKGVGFGDIFKDKPIKLRPRSIEVEN--DFLPVEKTIGKKLPATTA-- 216
                +     ++ G     IF    + +  R + V+N  D++ +  +      AT +  
Sbjct: 644 LRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPL-VKNPVDYMDLPFSSSPSRSATASPQ 702

Query: 217 ---------TPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDV 267
                    TPD S+T  D  +      + ++ Y  QNDDEL +++GDIV ++ K   D 
Sbjct: 703 QPQAQQRRVTPDRSQTSQDLFSY-----QALYSYIPQNDDELELRDGDIVDVMEK--CDD 755

Query: 268 GWWEGELNGRR--GVFPDNFVKLL 289
           GW+ G     +  G FP N+VK L
Sbjct: 756 GWFVGTSRRTKQFGTFPGNYVKPL 779



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 35/109 (32%), Positives = 58/109 (53%), Gaps = 11/109 (10%)

Query: 19  IKKEMKKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRC-------QVAFS 71
           IK+ + K+P+     + P    PS ++  S +      +R    R +        Q  +S
Sbjct: 673 IKRPLVKNPVDYM--DLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYS 730

Query: 72  YLPQNDDELELKVGDIIEVVGEVEEGWWEGV--LNGKTGMFPSNFIKEL 118
           Y+PQNDDELEL+ GDI++V+ + ++GW+ G      + G FP N++K L
Sbjct: 731 YIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 779



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 29/67 (43%), Positives = 43/67 (64%), Gaps = 5/67 (7%)

Query: 239 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGN 298
           F ++AQ   EL +++GDIV +  +  ID  W+EGE +GR G+FP  +++LLPP    E  
Sbjct: 549 FDFKAQTLKELPLQKGDIVYIYKQ--IDQNWYEGEHHGRVGIFPRTYIELLPP---AEKA 603

Query: 299 RPKKPPP 305
           +PKK  P
Sbjct: 604 QPKKLTP 610


>gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo
           sapiens]
          Length = 776

 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 44/133 (33%), Positives = 64/133 (48%), Gaps = 22/133 (16%)

Query: 15  SEIEIKKEMKKDPLTNKAPEKPLHEVPSG-NSLLSSETILRTNKRG---------ERRRR 64
           S +   K +      NKA E  L E P G +S LS+    +TN +G         +R+ +
Sbjct: 92  SGVNFSKVLSTLLAVNKATEDQLSERPCGRSSSLSAANTSQTNPQGAVSSTVSGLQRQSK 151

Query: 65  RCQVA------------FSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPS 112
             ++             F++   N+DEL +  GDII V    E GWWEG LNG+TG FPS
Sbjct: 152 TVEMTENGSHQLIVKARFNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPS 211

Query: 113 NFIKELSGESDEL 125
           N+++E+      L
Sbjct: 212 NYVREIKSSERPL 224



 Score = 56.2 bits (134), Expect = 9e-08
 Identities = 30/84 (35%), Positives = 44/84 (52%), Gaps = 7/84 (8%)

Query: 220 SSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRG 279
           S   EM      +   K  F ++  N+DEL++ +GDI+ +   +  + GWWEG LNGR G
Sbjct: 150 SKTVEMTENGSHQLIVKARFNFKQTNEDELSVCKGDIIYVTRVE--EGGWWEGTLNGRTG 207

Query: 280 VFPDNFVKLLPPDFEKEGNRPKKP 303
            FP N+V+ +     K   RP  P
Sbjct: 208 WFPSNYVREI-----KSSERPLSP 226


>gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo
           sapiens]
          Length = 492

 Score = 66.2 bits (160), Expect = 8e-11
 Identities = 35/81 (43%), Positives = 51/81 (62%), Gaps = 7/81 (8%)

Query: 230 KSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFV-KL 288
           K K   K ++ ++AQ   EL+ K+GD V ++ K  ID  W+EGE +GR G+FP ++V KL
Sbjct: 255 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRK--IDQNWYEGEHHGRVGIFPISYVEKL 312

Query: 289 LPPDFEKEGNRPKKPPPPSAP 309
            PP    E  +P +PPPP+ P
Sbjct: 313 TPP----EKAQPARPPPPAQP 329



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 53/280 (18%), Positives = 114/280 (40%), Gaps = 21/280 (7%)

Query: 29  TNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRR--------CQVAFSYLPQNDDEL 80
           T+ +P  P       +    S T+    +   R RR          +  + +  Q   EL
Sbjct: 215 TSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKEL 274

Query: 81  ELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRE 140
             K GD + ++ ++++ W+EG  +G+ G+FP +++++L+                  + E
Sbjct: 275 SFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGE 334

Query: 141 TTGSESDGGDSSSTKS--EGANGTVATAAIQ---PKKVKGVGFGDIFKDKPIKLRPRSIE 195
                +   D++   S  +G    +     Q     K+ G     IF    +++  ++ +
Sbjct: 335 AIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 394

Query: 196 VENDF----LPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTI 251
              D+    +P   +  +    ++  P       ++     +  + ++ Y  +N+DEL +
Sbjct: 395 GAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELEL 454

Query: 252 KEGDIVTLINKDCIDVGWWEGELNGRR--GVFPDNFVKLL 289
           +E D++ ++ K   D GW+ G     +  G FP N+VK L
Sbjct: 455 RESDVIDVMEK--CDDGWFVGTSRRTKFFGTFPGNYVKRL 492



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 32/131 (24%), Positives = 65/131 (49%), Gaps = 21/131 (16%)

Query: 239 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNG--RRGVFPDNFVKLLPPDFEKE 296
           + + A  + EL++++GD V L+ +  +D  W+EG++ G  R+G+FP ++V+++  + +  
Sbjct: 339 YNFNADTNVELSLRKGDRVILLKR--VDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGA 396

Query: 297 GNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEML---------PNRTEEKERPER 347
            + P  P P S         +++R H +    P+RP            P +      P  
Sbjct: 397 EDYPDPPIPHSY--------SSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRN 448

Query: 348 EPKLDLQKPSV 358
           E +L+L++  V
Sbjct: 449 EDELELRESDV 459



 Score = 34.7 bits (78), Expect = 0.27
 Identities = 45/189 (23%), Positives = 79/189 (41%), Gaps = 17/189 (8%)

Query: 291 PDFEKEGNRPKKPP--PPSAPVIKQGAGTTERKHEIKKIPPERP-EMLPNRTEEKERPER 347
           P+  K+ + P  PP  PP  P ++    ++  KH+    PP+R  +    R+E +   E 
Sbjct: 77  PNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWD--PPDRKVDTRKFRSEPRSIFEY 134

Query: 348 EP-KLDLQKPSVPA------IPPKKPRPPKTNSLS-----RPGALPPRRPERPVGPLTHT 395
           EP K  + +   PA      I     RP  + S++     R  + P   P R +G  + +
Sbjct: 135 EPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSAS 194

Query: 396 RGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPP 455
           R    ++DL GSS +       S  S+    +  +S  S +  L+    S P+     P 
Sbjct: 195 RTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPE 254

Query: 456 SQSLTSSSL 464
            + L + ++
Sbjct: 255 KEKLPAKAV 263


>gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo
           sapiens]
          Length = 1004

 Score = 66.2 bits (160), Expect = 8e-11
 Identities = 35/81 (43%), Positives = 51/81 (62%), Gaps = 7/81 (8%)

Query: 230 KSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFV-KL 288
           K K   K ++ ++AQ   EL+ K+GD V ++ K  ID  W+EGE +GR G+FP ++V KL
Sbjct: 767 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRK--IDQNWYEGEHHGRVGIFPISYVEKL 824

Query: 289 LPPDFEKEGNRPKKPPPPSAP 309
            PP    E  +P +PPPP+ P
Sbjct: 825 TPP----EKAQPARPPPPAQP 841



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 46/241 (19%), Positives = 104/241 (43%), Gaps = 13/241 (5%)

Query: 60   ERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELS 119
            E+ +   +  + +  Q   EL  K GD + ++ ++++ W+EG  +G+ G+FP +++++L+
Sbjct: 766  EKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLT 825

Query: 120  GESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKS--EGANGTVATAAIQ---PKKVK 174
                              + E     +   D++   S  +G    +     Q     K+ 
Sbjct: 826  PPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIP 885

Query: 175  GVGFGDIFKDKPIKLRPRSIEVENDF----LPVEKTIGKKLPATTATPDSSKTEMDSRTK 230
            G     IF    +++  ++ +   D+    +P   +  +    ++  P       ++   
Sbjct: 886  GTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQG 945

Query: 231  SKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRR--GVFPDNFVKL 288
              +  + ++ Y  +N+DEL ++E D++ ++ K   D GW+ G     +  G FP N+VK 
Sbjct: 946  GGEPFQALYNYTPRNEDELELRESDVIDVMEK--CDDGWFVGTSRRTKFFGTFPGNYVKR 1003

Query: 289  L 289
            L
Sbjct: 1004 L 1004



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 32/131 (24%), Positives = 65/131 (49%), Gaps = 21/131 (16%)

Query: 239 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNG--RRGVFPDNFVKLLPPDFEKE 296
           + + A  + EL++++GD V L+ +  +D  W+EG++ G  R+G+FP ++V+++  + +  
Sbjct: 851 YNFNADTNVELSLRKGDRVILLKR--VDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGA 908

Query: 297 GNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEML---------PNRTEEKERPER 347
            + P  P P S         +++R H +    P+RP            P +      P  
Sbjct: 909 EDYPDPPIPHSY--------SSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRN 960

Query: 348 EPKLDLQKPSV 358
           E +L+L++  V
Sbjct: 961 EDELELRESDV 971



 Score = 32.3 bits (72), Expect = 1.4
 Identities = 36/133 (27%), Positives = 59/133 (44%), Gaps = 17/133 (12%)

Query: 291 PDFEKEGNRPKKPP--PPSAPVIKQGAGTTERKHEIKKIPPERP-EMLPNRTEEKERPER 347
           P+  K+ + P  PP  PP  P ++    ++  KH+    PP+R  +    R+E +   E 
Sbjct: 62  PNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWD--PPDRKVDTRKFRSEPRSIFEY 119

Query: 348 EP-KLDLQKPSVPA------IPPKKPRPPKTNSLS-----RPGALPPRRPERPVGPLTHT 395
           EP K  + +   PA      I     RP  + S++     R  + P   P R +G  + +
Sbjct: 120 EPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSAS 179

Query: 396 RGDSPKIDLAGSS 408
           R    ++DL GSS
Sbjct: 180 RTSPGRVDLPGSS 192


>gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
           sapiens]
          Length = 824

 Score = 66.2 bits (160), Expect = 8e-11
 Identities = 35/81 (43%), Positives = 51/81 (62%), Gaps = 7/81 (8%)

Query: 230 KSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFV-KL 288
           K K   K ++ ++AQ   EL+ K+GD V ++ K  ID  W+EGE +GR G+FP ++V KL
Sbjct: 587 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRK--IDQNWYEGEHHGRVGIFPISYVEKL 644

Query: 289 LPPDFEKEGNRPKKPPPPSAP 309
            PP    E  +P +PPPP+ P
Sbjct: 645 TPP----EKAQPARPPPPAQP 661



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 53/280 (18%), Positives = 114/280 (40%), Gaps = 21/280 (7%)

Query: 29  TNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRR--------CQVAFSYLPQNDDEL 80
           T+ +P  P       +    S T+    +   R RR          +  + +  Q   EL
Sbjct: 547 TSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKEL 606

Query: 81  ELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRE 140
             K GD + ++ ++++ W+EG  +G+ G+FP +++++L+                  + E
Sbjct: 607 SFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGE 666

Query: 141 TTGSESDGGDSSSTKS--EGANGTVATAAIQ---PKKVKGVGFGDIFKDKPIKLRPRSIE 195
                +   D++   S  +G    +     Q     K+ G     IF    +++  ++ +
Sbjct: 667 AIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 726

Query: 196 VENDF----LPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTI 251
              D+    +P   +  +    ++  P       ++     +  + ++ Y  +N+DEL +
Sbjct: 727 GAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELEL 786

Query: 252 KEGDIVTLINKDCIDVGWWEGELNGRR--GVFPDNFVKLL 289
           +E D++ ++ K   D GW+ G     +  G FP N+VK L
Sbjct: 787 RESDVIDVMEK--CDDGWFVGTSRRTKFFGTFPGNYVKRL 824



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 32/131 (24%), Positives = 65/131 (49%), Gaps = 21/131 (16%)

Query: 239 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNG--RRGVFPDNFVKLLPPDFEKE 296
           + + A  + EL++++GD V L+ +  +D  W+EG++ G  R+G+FP ++V+++  + +  
Sbjct: 671 YNFNADTNVELSLRKGDRVILLKR--VDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGA 728

Query: 297 GNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEML---------PNRTEEKERPER 347
            + P  P P S         +++R H +    P+RP            P +      P  
Sbjct: 729 EDYPDPPIPHSY--------SSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRN 780

Query: 348 EPKLDLQKPSV 358
           E +L+L++  V
Sbjct: 781 EDELELRESDV 791



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 57/225 (25%), Positives = 80/225 (35%), Gaps = 50/225 (22%)

Query: 291 PDFEKEGNRPKKPP---PPSAPVIKQGAGTTE--------RKHEIKK------------- 326
           P+  K+ + P  PP   PP  P+  +   +TE        RK + +K             
Sbjct: 337 PNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEP 396

Query: 327 -----IPPERPEMLPNR-TEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGAL 380
                +  ERP  LP   T     P R+P    +   V   P   PR       SR  AL
Sbjct: 397 GKSSILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPAL 456

Query: 381 PPRRPERPVGPL----THTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSST 436
            P RP  P  PL     H+ G   +  L  SS+   L++ +S  S   D           
Sbjct: 457 SPTRP--PKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFR--------K 506

Query: 437 EKLSHPTTSRPKATGRRPPSQS------LTSSSLSSPDIFDSPSP 475
            + S P    P+  G +  S++      L  SS +    F S SP
Sbjct: 507 RRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSP 551


>gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo
           sapiens]
          Length = 661

 Score = 66.2 bits (160), Expect = 8e-11
 Identities = 35/81 (43%), Positives = 51/81 (62%), Gaps = 7/81 (8%)

Query: 230 KSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFV-KL 288
           K K   K ++ ++AQ   EL+ K+GD V ++ K  ID  W+EGE +GR G+FP ++V KL
Sbjct: 424 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRK--IDQNWYEGEHHGRVGIFPISYVEKL 481

Query: 289 LPPDFEKEGNRPKKPPPPSAP 309
            PP    E  +P +PPPP+ P
Sbjct: 482 TPP----EKAQPARPPPPAQP 498



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 53/280 (18%), Positives = 114/280 (40%), Gaps = 21/280 (7%)

Query: 29  TNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRR--------CQVAFSYLPQNDDEL 80
           T+ +P  P       +    S T+    +   R RR          +  + +  Q   EL
Sbjct: 384 TSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKEL 443

Query: 81  ELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRE 140
             K GD + ++ ++++ W+EG  +G+ G+FP +++++L+                  + E
Sbjct: 444 SFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGE 503

Query: 141 TTGSESDGGDSSSTKS--EGANGTVATAAIQ---PKKVKGVGFGDIFKDKPIKLRPRSIE 195
                +   D++   S  +G    +     Q     K+ G     IF    +++  ++ +
Sbjct: 504 AIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 563

Query: 196 VENDF----LPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTI 251
              D+    +P   +  +    ++  P       ++     +  + ++ Y  +N+DEL +
Sbjct: 564 GAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELEL 623

Query: 252 KEGDIVTLINKDCIDVGWWEGELNGRR--GVFPDNFVKLL 289
           +E D++ ++ K   D GW+ G     +  G FP N+VK L
Sbjct: 624 RESDVIDVMEK--CDDGWFVGTSRRTKFFGTFPGNYVKRL 661



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 32/131 (24%), Positives = 65/131 (49%), Gaps = 21/131 (16%)

Query: 239 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNG--RRGVFPDNFVKLLPPDFEKE 296
           + + A  + EL++++GD V L+ +  +D  W+EG++ G  R+G+FP ++V+++  + +  
Sbjct: 508 YNFNADTNVELSLRKGDRVILLKR--VDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGA 565

Query: 297 GNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEML---------PNRTEEKERPER 347
            + P  P P S         +++R H +    P+RP            P +      P  
Sbjct: 566 EDYPDPPIPHSY--------SSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRN 617

Query: 348 EPKLDLQKPSV 358
           E +L+L++  V
Sbjct: 618 EDELELRESDV 628


>gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo
           sapiens]
          Length = 731

 Score = 66.2 bits (160), Expect = 8e-11
 Identities = 35/81 (43%), Positives = 51/81 (62%), Gaps = 7/81 (8%)

Query: 230 KSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFV-KL 288
           K K   K ++ ++AQ   EL+ K+GD V ++ K  ID  W+EGE +GR G+FP ++V KL
Sbjct: 494 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRK--IDQNWYEGEHHGRVGIFPISYVEKL 551

Query: 289 LPPDFEKEGNRPKKPPPPSAP 309
            PP    E  +P +PPPP+ P
Sbjct: 552 TPP----EKAQPARPPPPAQP 568



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 53/280 (18%), Positives = 114/280 (40%), Gaps = 21/280 (7%)

Query: 29  TNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRR--------CQVAFSYLPQNDDEL 80
           T+ +P  P       +    S T+    +   R RR          +  + +  Q   EL
Sbjct: 454 TSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKEL 513

Query: 81  ELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRE 140
             K GD + ++ ++++ W+EG  +G+ G+FP +++++L+                  + E
Sbjct: 514 SFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGE 573

Query: 141 TTGSESDGGDSSSTKS--EGANGTVATAAIQ---PKKVKGVGFGDIFKDKPIKLRPRSIE 195
                +   D++   S  +G    +     Q     K+ G     IF    +++  ++ +
Sbjct: 574 AIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 633

Query: 196 VENDF----LPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTI 251
              D+    +P   +  +    ++  P       ++     +  + ++ Y  +N+DEL +
Sbjct: 634 GAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELEL 693

Query: 252 KEGDIVTLINKDCIDVGWWEGELNGRR--GVFPDNFVKLL 289
           +E D++ ++ K   D GW+ G     +  G FP N+VK L
Sbjct: 694 RESDVIDVMEK--CDDGWFVGTSRRTKFFGTFPGNYVKRL 731



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 32/131 (24%), Positives = 65/131 (49%), Gaps = 21/131 (16%)

Query: 239 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNG--RRGVFPDNFVKLLPPDFEKE 296
           + + A  + EL++++GD V L+ +  +D  W+EG++ G  R+G+FP ++V+++  + +  
Sbjct: 578 YNFNADTNVELSLRKGDRVILLKR--VDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGA 635

Query: 297 GNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEML---------PNRTEEKERPER 347
            + P  P P S         +++R H +    P+RP            P +      P  
Sbjct: 636 EDYPDPPIPHSY--------SSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRN 687

Query: 348 EPKLDLQKPSV 358
           E +L+L++  V
Sbjct: 688 EDELELRESDV 698



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 57/225 (25%), Positives = 80/225 (35%), Gaps = 50/225 (22%)

Query: 291 PDFEKEGNRPKKPP---PPSAPVIKQGAGTTE--------RKHEIKK------------- 326
           P+  K+ + P  PP   PP  P+  +   +TE        RK + +K             
Sbjct: 244 PNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEP 303

Query: 327 -----IPPERPEMLPNR-TEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGAL 380
                +  ERP  LP   T     P R+P    +   V   P   PR       SR  AL
Sbjct: 304 GKSSILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPAL 363

Query: 381 PPRRPERPVGPL----THTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSST 436
            P RP  P  PL     H+ G   +  L  SS+   L++ +S  S   D           
Sbjct: 364 SPTRP--PKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFR--------K 413

Query: 437 EKLSHPTTSRPKATGRRPPSQS------LTSSSLSSPDIFDSPSP 475
            + S P    P+  G +  S++      L  SS +    F S SP
Sbjct: 414 RRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSP 458


>gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo
           sapiens]
          Length = 644

 Score = 66.2 bits (160), Expect = 8e-11
 Identities = 35/81 (43%), Positives = 51/81 (62%), Gaps = 7/81 (8%)

Query: 230 KSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFV-KL 288
           K K   K ++ ++AQ   EL+ K+GD V ++ K  ID  W+EGE +GR G+FP ++V KL
Sbjct: 407 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRK--IDQNWYEGEHHGRVGIFPISYVEKL 464

Query: 289 LPPDFEKEGNRPKKPPPPSAP 309
            PP    E  +P +PPPP+ P
Sbjct: 465 TPP----EKAQPARPPPPAQP 481



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 53/280 (18%), Positives = 114/280 (40%), Gaps = 21/280 (7%)

Query: 29  TNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRR--------CQVAFSYLPQNDDEL 80
           T+ +P  P       +    S T+    +   R RR          +  + +  Q   EL
Sbjct: 367 TSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKEL 426

Query: 81  ELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRE 140
             K GD + ++ ++++ W+EG  +G+ G+FP +++++L+                  + E
Sbjct: 427 SFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGE 486

Query: 141 TTGSESDGGDSSSTKS--EGANGTVATAAIQ---PKKVKGVGFGDIFKDKPIKLRPRSIE 195
                +   D++   S  +G    +     Q     K+ G     IF    +++  ++ +
Sbjct: 487 AIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 546

Query: 196 VENDF----LPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTI 251
              D+    +P   +  +    ++  P       ++     +  + ++ Y  +N+DEL +
Sbjct: 547 GAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELEL 606

Query: 252 KEGDIVTLINKDCIDVGWWEGELNGRR--GVFPDNFVKLL 289
           +E D++ ++ K   D GW+ G     +  G FP N+VK L
Sbjct: 607 RESDVIDVMEK--CDDGWFVGTSRRTKFFGTFPGNYVKRL 644



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 32/131 (24%), Positives = 65/131 (49%), Gaps = 21/131 (16%)

Query: 239 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNG--RRGVFPDNFVKLLPPDFEKE 296
           + + A  + EL++++GD V L+ +  +D  W+EG++ G  R+G+FP ++V+++  + +  
Sbjct: 491 YNFNADTNVELSLRKGDRVILLKR--VDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGA 548

Query: 297 GNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEML---------PNRTEEKERPER 347
            + P  P P S         +++R H +    P+RP            P +      P  
Sbjct: 549 EDYPDPPIPHSY--------SSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRN 600

Query: 348 EPKLDLQKPSV 358
           E +L+L++  V
Sbjct: 601 EDELELRESDV 611



 Score = 34.7 bits (78), Expect = 0.27
 Identities = 45/189 (23%), Positives = 79/189 (41%), Gaps = 17/189 (8%)

Query: 291 PDFEKEGNRPKKPP--PPSAPVIKQGAGTTERKHEIKKIPPERP-EMLPNRTEEKERPER 347
           P+  K+ + P  PP  PP  P ++    ++  KH+    PP+R  +    R+E +   E 
Sbjct: 229 PNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWD--PPDRKVDTRKFRSEPRSIFEY 286

Query: 348 EP-KLDLQKPSVPA------IPPKKPRPPKTNSLS-----RPGALPPRRPERPVGPLTHT 395
           EP K  + +   PA      I     RP  + S++     R  + P   P R +G  + +
Sbjct: 287 EPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSAS 346

Query: 396 RGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPP 455
           R    ++DL GSS +       S  S+    +  +S  S +  L+    S P+     P 
Sbjct: 347 RTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPE 406

Query: 456 SQSLTSSSL 464
            + L + ++
Sbjct: 407 KEKLPAKAV 415


>gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo
           sapiens]
          Length = 1100

 Score = 66.2 bits (160), Expect = 8e-11
 Identities = 35/81 (43%), Positives = 51/81 (62%), Gaps = 7/81 (8%)

Query: 230 KSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFV-KL 288
           K K   K ++ ++AQ   EL+ K+GD V ++ K  ID  W+EGE +GR G+FP ++V KL
Sbjct: 863 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRK--IDQNWYEGEHHGRVGIFPISYVEKL 920

Query: 289 LPPDFEKEGNRPKKPPPPSAP 309
            PP    E  +P +PPPP+ P
Sbjct: 921 TPP----EKAQPARPPPPAQP 937



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 46/241 (19%), Positives = 104/241 (43%), Gaps = 13/241 (5%)

Query: 60   ERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELS 119
            E+ +   +  + +  Q   EL  K GD + ++ ++++ W+EG  +G+ G+FP +++++L+
Sbjct: 862  EKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLT 921

Query: 120  GESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKS--EGANGTVATAAIQ---PKKVK 174
                              + E     +   D++   S  +G    +     Q     K+ 
Sbjct: 922  PPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIP 981

Query: 175  GVGFGDIFKDKPIKLRPRSIEVENDF----LPVEKTIGKKLPATTATPDSSKTEMDSRTK 230
            G     IF    +++  ++ +   D+    +P   +  +    ++  P       ++   
Sbjct: 982  GTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQG 1041

Query: 231  SKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRR--GVFPDNFVKL 288
              +  + ++ Y  +N+DEL ++E D++ ++ K   D GW+ G     +  G FP N+VK 
Sbjct: 1042 GGEPFQALYNYTPRNEDELELRESDVIDVMEK--CDDGWFVGTSRRTKFFGTFPGNYVKR 1099

Query: 289  L 289
            L
Sbjct: 1100 L 1100



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 32/131 (24%), Positives = 65/131 (49%), Gaps = 21/131 (16%)

Query: 239  FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNG--RRGVFPDNFVKLLPPDFEKE 296
            + + A  + EL++++GD V L+ +  +D  W+EG++ G  R+G+FP ++V+++  + +  
Sbjct: 947  YNFNADTNVELSLRKGDRVILLKR--VDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGA 1004

Query: 297  GNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEML---------PNRTEEKERPER 347
             + P  P P S         +++R H +    P+RP            P +      P  
Sbjct: 1005 EDYPDPPIPHSY--------SSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRN 1056

Query: 348  EPKLDLQKPSV 358
            E +L+L++  V
Sbjct: 1057 EDELELRESDV 1067



 Score = 32.3 bits (72), Expect = 1.4
 Identities = 36/133 (27%), Positives = 59/133 (44%), Gaps = 17/133 (12%)

Query: 291 PDFEKEGNRPKKPP--PPSAPVIKQGAGTTERKHEIKKIPPERP-EMLPNRTEEKERPER 347
           P+  K+ + P  PP  PP  P ++    ++  KH+    PP+R  +    R+E +   E 
Sbjct: 158 PNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWD--PPDRKVDTRKFRSEPRSIFEY 215

Query: 348 EP-KLDLQKPSVPA------IPPKKPRPPKTNSLS-----RPGALPPRRPERPVGPLTHT 395
           EP K  + +   PA      I     RP  + S++     R  + P   P R +G  + +
Sbjct: 216 EPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSAS 275

Query: 396 RGDSPKIDLAGSS 408
           R    ++DL GSS
Sbjct: 276 RTSPGRVDLPGSS 288


>gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo
           sapiens]
          Length = 666

 Score = 66.2 bits (160), Expect = 8e-11
 Identities = 35/81 (43%), Positives = 51/81 (62%), Gaps = 7/81 (8%)

Query: 230 KSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFV-KL 288
           K K   K ++ ++AQ   EL+ K+GD V ++ K  ID  W+EGE +GR G+FP ++V KL
Sbjct: 429 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRK--IDQNWYEGEHHGRVGIFPISYVEKL 486

Query: 289 LPPDFEKEGNRPKKPPPPSAP 309
            PP    E  +P +PPPP+ P
Sbjct: 487 TPP----EKAQPARPPPPAQP 503



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 53/280 (18%), Positives = 114/280 (40%), Gaps = 21/280 (7%)

Query: 29  TNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRR--------CQVAFSYLPQNDDEL 80
           T+ +P  P       +    S T+    +   R RR          +  + +  Q   EL
Sbjct: 389 TSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKEL 448

Query: 81  ELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRE 140
             K GD + ++ ++++ W+EG  +G+ G+FP +++++L+                  + E
Sbjct: 449 SFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGE 508

Query: 141 TTGSESDGGDSSSTKS--EGANGTVATAAIQ---PKKVKGVGFGDIFKDKPIKLRPRSIE 195
                +   D++   S  +G    +     Q     K+ G     IF    +++  ++ +
Sbjct: 509 AIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 568

Query: 196 VENDF----LPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTI 251
              D+    +P   +  +    ++  P       ++     +  + ++ Y  +N+DEL +
Sbjct: 569 GAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELEL 628

Query: 252 KEGDIVTLINKDCIDVGWWEGELNGRR--GVFPDNFVKLL 289
           +E D++ ++ K   D GW+ G     +  G FP N+VK L
Sbjct: 629 RESDVIDVMEK--CDDGWFVGTSRRTKFFGTFPGNYVKRL 666



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 32/131 (24%), Positives = 65/131 (49%), Gaps = 21/131 (16%)

Query: 239 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNG--RRGVFPDNFVKLLPPDFEKE 296
           + + A  + EL++++GD V L+ +  +D  W+EG++ G  R+G+FP ++V+++  + +  
Sbjct: 513 YNFNADTNVELSLRKGDRVILLKR--VDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGA 570

Query: 297 GNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEML---------PNRTEEKERPER 347
            + P  P P S         +++R H +    P+RP            P +      P  
Sbjct: 571 EDYPDPPIPHSY--------SSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRN 622

Query: 348 EPKLDLQKPSV 358
           E +L+L++  V
Sbjct: 623 EDELELRESDV 633


>gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo
           sapiens]
          Length = 671

 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 73/255 (28%), Positives = 110/255 (43%), Gaps = 65/255 (25%)

Query: 212 PATTATPDSSK---TEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVG 268
           P++T  P +S    +      K +   ++ F ++AQ+  ELT+++GDIV  I+K+ +D  
Sbjct: 359 PSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIV-YIHKE-VDKN 416

Query: 269 WWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTE--------- 319
           W EGE +GR G+FP N+V++LP D       PK   PP+  V++ G    +         
Sbjct: 417 WLEGEHHGRLGIFPANYVEVLPAD-----EIPKPIKPPTYQVLEYGEAVAQYTFKGDLEV 471

Query: 320 ----RKHE----IKKIPPERPEMLPNRTEEK-------ERPEREPKLDL--QKPSVPAIP 362
               RK E    I+K+     E     T  +        +  REP+L L    P +P  P
Sbjct: 472 ELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSP 531

Query: 363 -----PKKPRPPKTNSLSRPGALP----------------PRRPERP-------VGP-LT 393
                 +  R P + S  R  A P                P +  RP        GP L+
Sbjct: 532 RLTAAARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALS 591

Query: 394 HTRGDSPKIDLAGSS 408
           H+RG S  +DL  SS
Sbjct: 592 HSRGPSHPLDLGTSS 606



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 22/65 (33%), Positives = 43/65 (66%)

Query: 57  KRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIK 116
           +R E++R+  ++ F +  Q+  EL L+ GDI+ +  EV++ W EG  +G+ G+FP+N+++
Sbjct: 376 RREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVE 435

Query: 117 ELSGE 121
            L  +
Sbjct: 436 VLPAD 440



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 50/213 (23%), Positives = 94/213 (44%), Gaps = 21/213 (9%)

Query: 79  ELELKVGDIIEVVGEVEEGWWEGVLNG--KTGMFPSNFIKELSGESDELGISQDEQLSKS 136
           EL  + G+ I ++ +V E W+EG + G  + G+FP+++++        L +  D     +
Sbjct: 472 ELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQV--SREPRLRLCDDGPQLPT 529

Query: 137 SLRETTGSESDGGDSS-STKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIE 195
           S R T  + S    SS S     A+         P++      G  F  +  + + +++ 
Sbjct: 530 SPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRRT-----GFSFPTQEPRPQTQNLG 584

Query: 196 VENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGD 255
                L   +     L   T++P++S+             + ++ Y  QN+DEL ++EGD
Sbjct: 585 TPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPY-------RAMYQYRPQNEDELELREGD 637

Query: 256 IVTLINKDCIDVGWWEG--ELNGRRGVFPDNFV 286
            V ++ +   D GW+ G      + G FP N+V
Sbjct: 638 RVDVMQQ--CDDGWFVGVSRRTQKFGTFPGNYV 668



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 21/48 (43%), Positives = 33/48 (68%), Gaps = 2/48 (4%)

Query: 70  FSYLPQNDDELELKVGDIIEVVGEVEEGWWEGV--LNGKTGMFPSNFI 115
           + Y PQN+DELEL+ GD ++V+ + ++GW+ GV     K G FP N++
Sbjct: 621 YQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 668


>gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo
           sapiens]
          Length = 329

 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 73/255 (28%), Positives = 110/255 (43%), Gaps = 65/255 (25%)

Query: 212 PATTATPDSSK---TEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVG 268
           P++T  P +S    +      K +   ++ F ++AQ+  ELT+++GDIV  I+K+ +D  
Sbjct: 17  PSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIV-YIHKE-VDKN 74

Query: 269 WWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTE--------- 319
           W EGE +GR G+FP N+V++LP D       PK   PP+  V++ G    +         
Sbjct: 75  WLEGEHHGRLGIFPANYVEVLPAD-----EIPKPIKPPTYQVLEYGEAVAQYTFKGDLEV 129

Query: 320 ----RKHE----IKKIPPERPEMLPNRTEEK-------ERPEREPKLDL--QKPSVPAIP 362
               RK E    I+K+     E     T  +        +  REP+L L    P +P  P
Sbjct: 130 ELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSP 189

Query: 363 -----PKKPRPPKTNSLSRPGALP----------------PRRPERP-------VGP-LT 393
                 +  R P + S  R  A P                P +  RP        GP L+
Sbjct: 190 RLTAAARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALS 249

Query: 394 HTRGDSPKIDLAGSS 408
           H+RG S  +DL  SS
Sbjct: 250 HSRGPSHPLDLGTSS 264



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 22/65 (33%), Positives = 43/65 (66%)

Query: 57  KRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIK 116
           +R E++R+  ++ F +  Q+  EL L+ GDI+ +  EV++ W EG  +G+ G+FP+N+++
Sbjct: 34  RREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVE 93

Query: 117 ELSGE 121
            L  +
Sbjct: 94  VLPAD 98



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 50/213 (23%), Positives = 94/213 (44%), Gaps = 21/213 (9%)

Query: 79  ELELKVGDIIEVVGEVEEGWWEGVLNG--KTGMFPSNFIKELSGESDELGISQDEQLSKS 136
           EL  + G+ I ++ +V E W+EG + G  + G+FP+++++        L +  D     +
Sbjct: 130 ELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQV--SREPRLRLCDDGPQLPT 187

Query: 137 SLRETTGSESDGGDSS-STKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIE 195
           S R T  + S    SS S     A+         P++      G  F  +  + + +++ 
Sbjct: 188 SPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRRT-----GFSFPTQEPRPQTQNLG 242

Query: 196 VENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGD 255
                L   +     L   T++P++S+             + ++ Y  QN+DEL ++EGD
Sbjct: 243 TPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPY-------RAMYQYRPQNEDELELREGD 295

Query: 256 IVTLINKDCIDVGWWEG--ELNGRRGVFPDNFV 286
            V ++ +   D GW+ G      + G FP N+V
Sbjct: 296 RVDVMQQ--CDDGWFVGVSRRTQKFGTFPGNYV 326



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 21/48 (43%), Positives = 33/48 (68%), Gaps = 2/48 (4%)

Query: 70  FSYLPQNDDELELKVGDIIEVVGEVEEGWWEGV--LNGKTGMFPSNFI 115
           + Y PQN+DELEL+ GD ++V+ + ++GW+ GV     K G FP N++
Sbjct: 279 YQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 326


>gi|166064036 PAK-interacting exchange factor beta isoform d [Homo
           sapiens]
          Length = 753

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 34/93 (36%), Positives = 49/93 (52%), Gaps = 12/93 (12%)

Query: 38  HEVPSGNSLLSSETILRTNKRGERRRRRCQVA------------FSYLPQNDDELELKVG 85
           H + S +SL S     RT+K  + + R   +             F++   N+DEL    G
Sbjct: 99  HRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNEDELSFSKG 158

Query: 86  DIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKEL 118
           D+I V    E GWWEG LNG+TG FPSN+++E+
Sbjct: 159 DVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREV 191



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 27/89 (30%), Positives = 47/89 (52%), Gaps = 10/89 (11%)

Query: 224 EMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPD 283
           +M   + ++   +  F ++  N+DEL+  +GD++ +   +  + GWWEG LNGR G FP 
Sbjct: 128 DMTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVE--EGGWWEGTLNGRTGWFPS 185

Query: 284 NFVKLLPPDFEKEGNRPKKPPPPSAPVIK 312
           N+V        +E    +KP  P +  +K
Sbjct: 186 NYV--------REVKASEKPVSPKSGTLK 206


>gi|166064034 PAK-interacting exchange factor beta isoform c [Homo
           sapiens]
          Length = 803

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 34/93 (36%), Positives = 49/93 (52%), Gaps = 12/93 (12%)

Query: 38  HEVPSGNSLLSSETILRTNKRGERRRRRCQVA------------FSYLPQNDDELELKVG 85
           H + S +SL S     RT+K  + + R   +             F++   N+DEL    G
Sbjct: 149 HRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNEDELSFSKG 208

Query: 86  DIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKEL 118
           D+I V    E GWWEG LNG+TG FPSN+++E+
Sbjct: 209 DVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREV 241



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 27/89 (30%), Positives = 47/89 (52%), Gaps = 10/89 (11%)

Query: 224 EMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPD 283
           +M   + ++   +  F ++  N+DEL+  +GD++ +   +  + GWWEG LNGR G FP 
Sbjct: 178 DMTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVE--EGGWWEGTLNGRTGWFPS 235

Query: 284 NFVKLLPPDFEKEGNRPKKPPPPSAPVIK 312
           N+V        +E    +KP  P +  +K
Sbjct: 236 NYV--------REVKASEKPVSPKSGTLK 256


>gi|22027528 PAK-interacting exchange factor beta isoform b [Homo
           sapiens]
          Length = 782

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 34/93 (36%), Positives = 49/93 (52%), Gaps = 12/93 (12%)

Query: 38  HEVPSGNSLLSSETILRTNKRGERRRRRCQVA------------FSYLPQNDDELELKVG 85
           H + S +SL S     RT+K  + + R   +             F++   N+DEL    G
Sbjct: 128 HRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNEDELSFSKG 187

Query: 86  DIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKEL 118
           D+I V    E GWWEG LNG+TG FPSN+++E+
Sbjct: 188 DVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREV 220



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 27/89 (30%), Positives = 47/89 (52%), Gaps = 10/89 (11%)

Query: 224 EMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPD 283
           +M   + ++   +  F ++  N+DEL+  +GD++ +   +  + GWWEG LNGR G FP 
Sbjct: 157 DMTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVE--EGGWWEGTLNGRTGWFPS 214

Query: 284 NFVKLLPPDFEKEGNRPKKPPPPSAPVIK 312
           N+V        +E    +KP  P +  +K
Sbjct: 215 NYV--------REVKASEKPVSPKSGTLK 235


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.307    0.128    0.359 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,281,355
Number of Sequences: 37866
Number of extensions: 1659489
Number of successful extensions: 15303
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 310
Number of HSP's successfully gapped in prelim test: 938
Number of HSP's that attempted gapping in prelim test: 11024
Number of HSP's gapped (non-prelim): 4354
length of query: 628
length of database: 18,247,518
effective HSP length: 108
effective length of query: 520
effective length of database: 14,157,990
effective search space: 7362154800
effective search space used: 7362154800
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.