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Search of human proteins with 6382062
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
(1182 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 2390 0.0
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 2284 0.0
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 2239 0.0
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 1296 0.0
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 1081 0.0
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 1080 0.0
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 1077 0.0
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] 371 e-102
gi|4503787 fyn-related kinase [Homo sapiens] 370 e-102
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 369 e-101
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens] 368 e-101
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 364 e-100
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 364 e-100
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi... 364 e-100
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 359 7e-99
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 359 7e-99
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 358 1e-98
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 358 1e-98
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 355 2e-97
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ... 348 2e-95
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is... 347 4e-95
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens] 344 2e-94
gi|130977759 tec protein tyrosine kinase [Homo sapiens] 332 1e-90
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens] 331 3e-90
gi|148596974 TXK tyrosine kinase [Homo sapiens] 322 1e-87
gi|187475373 c-src tyrosine kinase [Homo sapiens] 316 7e-86
gi|4758078 c-src tyrosine kinase [Homo sapiens] 316 7e-86
gi|18250298 src-related kinase lacking C-terminal regulatory tyr... 305 2e-82
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens] 305 2e-82
gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens] 295 2e-79
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 2390 bits (6193), Expect = 0.0
Identities = 1182/1182 (100%), Positives = 1182/1182 (100%)
Query: 1 MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQHDHFASCVE 60
MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQHDHFASCVE
Sbjct: 1 MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQHDHFASCVE 60
Query: 61 DGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVA 120
DGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVA
Sbjct: 61 DGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVA 120
Query: 121 SGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSR 180
SGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSR
Sbjct: 121 SGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSR 180
Query: 181 SAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFST 240
SAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFST
Sbjct: 181 SAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFST 240
Query: 241 LAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYG 300
LAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYG
Sbjct: 241 LAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYG 300
Query: 301 EVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIV 360
EVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIV
Sbjct: 301 EVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIV 360
Query: 361 TEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN 420
TEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN
Sbjct: 361 TEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN 420
Query: 421 HVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIAT 480
HVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIAT
Sbjct: 421 HVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIAT 480
Query: 481 YGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE 540
YGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE
Sbjct: 481 YGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE 540
Query: 541 TMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATE 600
TMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATE
Sbjct: 541 TMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATE 600
Query: 601 NSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKR 660
NSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKR
Sbjct: 601 NSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKR 660
Query: 661 NAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGG 720
NAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGG
Sbjct: 661 NAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGG 720
Query: 721 SFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPR 780
SFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPR
Sbjct: 721 SFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPR 780
Query: 781 SNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEES 840
SNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEES
Sbjct: 781 SNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEES 840
Query: 841 AAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLG 900
AAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLG
Sbjct: 841 AAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLG 900
Query: 901 MAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKL 960
MAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKL
Sbjct: 901 MAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKL 960
Query: 961 LSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQE 1020
LSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQE
Sbjct: 961 LSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQE 1020
Query: 1021 GGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKIS 1080
GGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKIS
Sbjct: 1021 GGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKIS 1080
Query: 1081 ADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAV 1140
ADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAV
Sbjct: 1081 ADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAV 1140
Query: 1141 SKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR 1182
SKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR
Sbjct: 1141 SKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR 1182
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 2284 bits (5919), Expect = 0.0
Identities = 1130/1130 (100%), Positives = 1130/1130 (100%)
Query: 53 DHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLF 112
DHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLF
Sbjct: 38 DHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLF 97
Query: 113 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHS 172
VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHS
Sbjct: 98 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHS 157
Query: 173 WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYV 232
WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYV
Sbjct: 158 WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYV 217
Query: 233 TAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKH 292
TAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKH
Sbjct: 218 TAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKH 277
Query: 293 KLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT 352
KLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT
Sbjct: 278 KLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT 337
Query: 353 LEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAA 412
LEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAA
Sbjct: 338 LEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAA 397
Query: 413 RNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFG 472
RNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFG
Sbjct: 398 RNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFG 457
Query: 473 VLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF 532
VLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF
Sbjct: 458 VLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF 517
Query: 533 AETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENI 592
AETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENI
Sbjct: 518 AETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENI 577
Query: 593 EGAQDATENSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGF 652
EGAQDATENSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGF
Sbjct: 578 EGAQDATENSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGF 637
Query: 653 FSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANL 712
FSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANL
Sbjct: 638 FSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANL 697
Query: 713 VPPKCYGGSFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASD 772
VPPKCYGGSFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASD
Sbjct: 698 VPPKCYGGSFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASD 757
Query: 773 DTSKPFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDM 832
DTSKPFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDM
Sbjct: 758 DTSKPFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDM 817
Query: 833 LPKKSEESAAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKE 892
LPKKSEESAAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKE
Sbjct: 818 LPKKSEESAAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKE 877
Query: 893 KNGGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTD 952
KNGGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTD
Sbjct: 878 KNGGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTD 937
Query: 953 SQGNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAG 1012
SQGNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAG
Sbjct: 938 SQGNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAG 997
Query: 1013 QSTSETQEGGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKT 1072
QSTSETQEGGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKT
Sbjct: 998 QSTSETQEGGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKT 1057
Query: 1073 KQAAEKISADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRN 1132
KQAAEKISADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRN
Sbjct: 1058 KQAAEKISADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRN 1117
Query: 1133 KFAFREAVSKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR 1182
KFAFREAVSKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR
Sbjct: 1118 KFAFREAVSKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR 1167
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 2239 bits (5801), Expect = 0.0
Identities = 1109/1109 (100%), Positives = 1109/1109 (100%)
Query: 74 EALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEK 133
EALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEK
Sbjct: 38 EALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEK 97
Query: 134 LRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLING 193
LRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLING
Sbjct: 98 LRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLING 157
Query: 194 SFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVAD 253
SFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVAD
Sbjct: 158 SFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVAD 217
Query: 254 GLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLT 313
GLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLT
Sbjct: 218 GLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLT 277
Query: 314 VAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYL 373
VAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYL
Sbjct: 278 VAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYL 337
Query: 374 RECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRL 433
RECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRL
Sbjct: 338 RECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRL 397
Query: 434 MTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ 493
MTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ
Sbjct: 398 MTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ 457
Query: 494 VYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVA 553
VYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVA
Sbjct: 458 VYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVA 517
Query: 554 EELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRG 613
EELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRG
Sbjct: 518 EELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRG 577
Query: 614 AQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFR 673
AQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFR
Sbjct: 578 AQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFR 637
Query: 674 EMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGG 733
EMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGG
Sbjct: 638 EMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGG 697
Query: 734 GGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPE 793
GGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPE
Sbjct: 698 GGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPE 757
Query: 794 QDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLL 853
QDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLL
Sbjct: 758 QDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLL 817
Query: 854 PRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGW 913
PRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGW
Sbjct: 818 PRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGW 877
Query: 914 PSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKD 973
PSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKD
Sbjct: 878 PSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKD 937
Query: 974 RPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPIS 1033
RPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPIS
Sbjct: 938 RPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPIS 997
Query: 1034 GKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECA 1093
GKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECA
Sbjct: 998 GKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECA 1057
Query: 1094 DLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVS 1153
DLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVS
Sbjct: 1058 DLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVS 1117
Query: 1154 SAAAGVPGTNPVLNNLLSCVQEISDVVQR 1182
SAAAGVPGTNPVLNNLLSCVQEISDVVQR
Sbjct: 1118 SAAAGVPGTNPVLNNLLSCVQEISDVVQR 1146
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 1296 bits (3355), Expect = 0.0
Identities = 635/635 (100%), Positives = 635/635 (100%)
Query: 53 DHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLF 112
DHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLF
Sbjct: 38 DHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLF 97
Query: 113 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHS 172
VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHS
Sbjct: 98 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHS 157
Query: 173 WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYV 232
WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYV
Sbjct: 158 WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYV 217
Query: 233 TAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKH 292
TAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKH
Sbjct: 218 TAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKH 277
Query: 293 KLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT 352
KLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT
Sbjct: 278 KLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT 337
Query: 353 LEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAA 412
LEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAA
Sbjct: 338 LEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAA 397
Query: 413 RNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFG 472
RNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFG
Sbjct: 398 RNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFG 457
Query: 473 VLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF 532
VLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF
Sbjct: 458 VLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF 517
Query: 533 AETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENI 592
AETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENI
Sbjct: 518 AETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENI 577
Query: 593 EGAQDATENSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGF 652
EGAQDATENSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGF
Sbjct: 578 EGAQDATENSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGF 637
Query: 653 FSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTG 687
FSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTG
Sbjct: 638 FSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTG 672
Score = 783 bits (2021), Expect = 0.0
Identities = 393/394 (99%), Positives = 394/394 (100%)
Query: 789 SGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERP 848
+GLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERP
Sbjct: 671 TGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERP 730
Query: 849 KAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDG 908
KAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDG
Sbjct: 731 KAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDG 790
Query: 909 EQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTS 968
EQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTS
Sbjct: 791 EQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTS 850
Query: 969 SGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALG 1028
SGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALG
Sbjct: 851 SGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALG 910
Query: 1029 AVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEA 1088
AVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEA
Sbjct: 911 AVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEA 970
Query: 1089 LLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQ 1148
LLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQ
Sbjct: 971 LLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQ 1030
Query: 1149 ELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR 1182
ELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR
Sbjct: 1031 ELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR 1064
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 1081 bits (2796), Expect = 0.0
Identities = 647/1239 (52%), Positives = 778/1239 (62%), Gaps = 147/1239 (11%)
Query: 1 MGQQVGRV-GEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQHDHFASCV 59
MGQQ G+V G+ P I+G+ + S R P N+F +H
Sbjct: 1 MGQQPGKVLGDQRRPSLPALHFIKGAGK-KESSRHGGPH-------CNVFVEH------- 45
Query: 60 EDGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLL-GATESDPNLFVALYDF 118
EAL RP D EPQ L+EA RW+SKENLL G +E+DPNLFVALYDF
Sbjct: 46 --------------EALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDF 91
Query: 119 VASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPV 178
VASGDNTLSITKGEKLRVLGYN NGEW E ++KNGQGWVPSNYITPVNSLEKHSWYHGPV
Sbjct: 92 VASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPV 151
Query: 179 SRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRF 238
SR+AAEYLLSS INGSFLVRESESSPGQ SISLRYEGRVYHYRINT +DGK+YV++ESRF
Sbjct: 152 SRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRF 211
Query: 239 STLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQ 298
+TLAELVHHHSTVADGL+TTLHYPAPK NKPTVYGVSP +DKWEMERTDITMKHKLGGGQ
Sbjct: 212 NTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQ 271
Query: 299 YGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFY 358
YGEVY GVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT EPPFY
Sbjct: 272 YGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFY 331
Query: 359 IVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG 418
I+TE+M YGNLLDYLRECNR+EV AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG
Sbjct: 332 IITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG 391
Query: 419 ENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEI 478
ENH+VKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYN FSIKSDVWAFGVLLWEI
Sbjct: 392 ENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEI 451
Query: 479 ATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQA 538
ATYGMSPYPGIDLSQVY+LLEK YRME+PEGCP KVYELMRACW+W+P+DRPSFAE HQA
Sbjct: 452 ATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQA 511
Query: 539 FETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDA 598
FETMF +SSIS+EV +ELG+ +V L + P LP+KTRT ++ E+++ + +
Sbjct: 512 FETMFQESSISDEVEKELGKQGVRGAVSTLL-QAPELPTKTRTSRRAAEHRDTTDVPEMP 570
Query: 599 TENSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFM- 657
P + SP LPRK+R L ED E +D+K FS+ +
Sbjct: 571 HSKGQGESDP----LDHEPAVSPLLPRKERGPPEGGLNED--ERLLPKDKKTNLFSALIK 624
Query: 658 -KKRNAPTPPKRSSSFREMENQPHKK--YELTGNFSSVASLQHADGFSFTPAQQEANLVP 714
KK+ APTPPKRSSSFREM+ QP ++ E G S +L +FTP
Sbjct: 625 KKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGAL------AFTPLDTADPAKS 678
Query: 715 PKCYGGSFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRA-----GKPT 769
PK G+ + GG +GF +P L KK+ L + G+
Sbjct: 679 PKPSNGAGVPNGALRESGG---------------SGFRSPHLWKKSSTLTSSRLATGEEE 723
Query: 770 ASDDTSKPFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRA 829
+SK F RS S S + G + + ++TLPR+ Q + Q + +
Sbjct: 724 GGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGG---------- 773
Query: 830 NDMLPKKSEESAAPSRE--RPKAKLLPRGATALPLR-TPSGDLAITE------KDPPGVG 880
KSE+ A P + ++ + RG P R + A E + PG
Sbjct: 774 -----HKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSS 828
Query: 881 VAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLK 940
+ P ++ G+ E G+ +PA A PV PT+ K
Sbjct: 829 PPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTS---KAGSGAPGGTS 885
Query: 941 HTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICS 1000
PA+ +S+ + K SE + DK + R+KP APPPPP
Sbjct: 886 KGPAE------ESRVRRHKHSSE---SPGRDKGKLSRLKP--APPPPPA---ASAGKAGG 931
Query: 1001 DPTEEPTALTAGQST---------------------SETQEGGKKAALGAVPISGKA--- 1036
P++ P+ AG++ S+ EG KK L A P A
Sbjct: 932 KPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPS 991
Query: 1037 GRPVMPPPQVP--LPTSSISPA-KMANGTA-----GTKVALRKTKQAAEKISADKISKEA 1088
G P+ P P VP LP++S + A + TA T+V+LRKT+Q E+I++ I+K
Sbjct: 992 GTPISPAP-VPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGV 1050
Query: 1089 LLECADLLSSALT----EPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLE 1144
+L+ + L A++ + +S +++ G L +C YVD I Q RNKFAFREA++KLE
Sbjct: 1051 VLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLE 1110
Query: 1145 LSLQELQVSSAAAGV-PGTNPVLNNLLSCVQEISDVVQR 1182
+L+ELQ+ A AG P + LLS V+EISD+VQR
Sbjct: 1111 NNLRELQICPATAGSGPAATQDFSKLLSSVKEISDIVQR 1149
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 1080 bits (2794), Expect = 0.0
Identities = 631/1165 (54%), Positives = 755/1165 (64%), Gaps = 117/1165 (10%)
Query: 74 EALHRPYGCDVEPQALNEAIRWSSKENLL-GATESDPNLFVALYDFVASGDNTLSITKGE 132
EAL RP D EPQ L+EA RW+SKENLL G +E+DPNLFVALYDFVASGDNTLSITKGE
Sbjct: 27 EALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGE 86
Query: 133 KLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN 192
KLRVLGYN NGEW E ++KNGQGWVPSNYITPVNSLEKHSWYHGPVSR+AAEYLLSS IN
Sbjct: 87 KLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGIN 146
Query: 193 GSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVA 252
GSFLVRESESSPGQ SISLRYEGRVYHYRINT +DGK+YV++ESRF+TLAELVHHHSTVA
Sbjct: 147 GSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVA 206
Query: 253 DGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSL 312
DGL+TTLHYPAPK NKPTVYGVSP +DKWEMERTDITMKHKLGGGQYGEVY GVWKKYSL
Sbjct: 207 DGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSL 266
Query: 313 TVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDY 372
TVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT EPPFYI+TE+M YGNLLDY
Sbjct: 267 TVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDY 326
Query: 373 LRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR 432
LRECNR+EV AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENH+VKVADFGLSR
Sbjct: 327 LRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSR 386
Query: 433 LMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLS 492
LMTGDTYTAHAGAKFPIKWTAPESLAYN FSIKSDVWAFGVLLWEIATYGMSPYPGIDLS
Sbjct: 387 LMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLS 446
Query: 493 QVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEV 552
QVY+LLEK YRME+PEGCP KVYELMRACW+W+P+DRPSFAE HQAFETMF +SSIS+EV
Sbjct: 447 QVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEV 506
Query: 553 AEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIR 612
+ELG+ +V L + P LP+KTRT ++ E+++ + + P
Sbjct: 507 EKELGKQGVRGAVSTLL-QAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDP---- 561
Query: 613 GAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFM--KKRNAPTPPKRSS 670
+ SP LPRK+R L ED E +D+K FS+ + KK+ APTPPKRSS
Sbjct: 562 LDHEPAVSPLLPRKERGPPEGGLNED--ERLLPKDKKTNLFSALIKKKKKTAPTPPKRSS 619
Query: 671 SFREMENQPHKK--YELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLC 728
SFREM+ QP ++ E G S +L +FTP PK G+
Sbjct: 620 SFREMDGQPERRGAGEEEGRDISNGAL------AFTPLDTADPAKSPKPSNGAGVPNGAL 673
Query: 729 NDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRA-----GKPTASDDTSKPFPRSNS 783
+ GG +GF +P L KK+ L + G+ +SK F RS S
Sbjct: 674 RESGG---------------SGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCS 718
Query: 784 TSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAP 843
S + G + + ++TLPR+ Q + Q + + KSE+ A P
Sbjct: 719 ASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGG---------------HKSEKPALP 763
Query: 844 SRE--RPKAKLLPRGATALPLR-TPSGDLAITE------KDPPGVGVAGVAAAPKGKEKN 894
+ ++ + RG P R + A E + PG + P ++
Sbjct: 764 RKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVT 823
Query: 895 GGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQ 954
G+ E G+ +PA A PV PT+ K PA+ +S+
Sbjct: 824 VAPASGLPHKEEAGKGSALGTPAAAEPVTPTS---KAGSGAPGGTSKGPAE------ESR 874
Query: 955 GNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQS 1014
+ K SE + DK + R+KP APPPPP P++ P+ AG++
Sbjct: 875 VRRHKHSSE---SPGRDKGKLSRLKP--APPPPPA---ASAGKAGGKPSQSPSQEAAGEA 926
Query: 1015 T---------------------SETQEGGKKAALGAVPISGKA---GRPVMPPPQVP--L 1048
S+ EG KK L A P A G P+ P P VP L
Sbjct: 927 VLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAP-VPSTL 985
Query: 1049 PTSSISPA-KMANGTA-----GTKVALRKTKQAAEKISADKISKEALLECADLLSSALT- 1101
P++S + A + TA T+V+LRKT+Q E+I++ I+K +L+ + L A++
Sbjct: 986 PSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISR 1045
Query: 1102 ---EPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSAAAG 1158
+ +S +++ G L +C YVD I Q RNKFAFREA++KLE +L+ELQ+ A AG
Sbjct: 1046 NSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQICPATAG 1105
Query: 1159 V-PGTNPVLNNLLSCVQEISDVVQR 1182
P + LLS V+EISD+VQR
Sbjct: 1106 SGPAATQDFSKLLSSVKEISDIVQR 1130
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 1077 bits (2784), Expect = 0.0
Identities = 529/550 (96%), Positives = 529/550 (96%), Gaps = 21/550 (3%)
Query: 1 MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQHDHFASCVE 60
MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQH
Sbjct: 1 MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQH-------- 52
Query: 61 DGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVA 120
EALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVA
Sbjct: 53 -------------EALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVA 99
Query: 121 SGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSR 180
SGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSR
Sbjct: 100 SGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSR 159
Query: 181 SAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFST 240
SAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFST
Sbjct: 160 SAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFST 219
Query: 241 LAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYG 300
LAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYG
Sbjct: 220 LAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYG 279
Query: 301 EVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIV 360
EVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIV
Sbjct: 280 EVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIV 339
Query: 361 TEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN 420
TEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN
Sbjct: 340 TEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN 399
Query: 421 HVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIAT 480
HVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIAT
Sbjct: 400 HVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIAT 459
Query: 481 YGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE 540
YGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE
Sbjct: 460 YGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE 519
Query: 541 TMFHDSSISE 550
TMFHDSSISE
Sbjct: 520 TMFHDSSISE 529
>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
Length = 534
Score = 371 bits (952), Expect = e-102
Identities = 201/455 (44%), Positives = 281/455 (61%), Gaps = 15/455 (3%)
Query: 111 LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSL 168
LFVALYD+ A ++ LS KGEK ++L ++ G+W E RS G++PSNY+ PV+S+
Sbjct: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSE-GDWWEARSLTTGETGYIPSNYVAPVDSI 144
Query: 169 EKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR-----YEGRVYHYR 221
+ WY G + R AE L S N G+FL+RESE++ G S+S+R V HY+
Sbjct: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK 204
Query: 222 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKW 281
I +G Y+T ++F TL +LV H+S ADGL L A C P G++ D W
Sbjct: 205 IRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCT-PQTSGLAK--DAW 261
Query: 282 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 341
E+ R + ++ KLG G + EV++G W + VA+KTLK TM E FL+EA +MK++KH
Sbjct: 262 EVARRSLCLEKKLGQGCFAEVWLGTWNG-NTKVAIKTLKPGTMSPESFLEEAQIMKKLKH 320
Query: 342 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 401
LVQL V + E P YIVTEYM G+LLD+L++ + L+ MA Q+++ M Y+E
Sbjct: 321 DKLVQLYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIE 379
Query: 402 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 461
+ N+IHRDL + N LVG + K+ADFGL+RL+ + YTA GAKFPIKWTAPE+ Y
Sbjct: 380 RMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 439
Query: 462 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 521
F+IKSDVW+FG+LL E+ T G PYPG++ +V + +E+GYRM P+ CP ++ELM C
Sbjct: 440 FTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHC 499
Query: 522 WKWSPADRPSFAETHQAFETMFHDSSISEEVAEEL 556
WK P +RP+F E F + + E L
Sbjct: 500 WKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 534
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 370 bits (949), Expect = e-102
Identities = 198/454 (43%), Positives = 273/454 (60%), Gaps = 16/454 (3%)
Query: 112 FVALYDFVASGDNTLSITKGEKLRVLGYNQNGEW--------SEVRSKNGQGWVPSNYIT 163
FVAL+D+ A LS G+KL+VL G W + S+ QG++PSNY+
Sbjct: 47 FVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVA 106
Query: 164 PVNSLEKHSWYHGPVSRSAAE--YLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYR 221
SL+ W+ G + RS AE L S GSFL+RESES G+ S+S+ V HYR
Sbjct: 107 EDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYR 166
Query: 222 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVS-PIHDK 280
I +G ++T FSTL E V H++ +DGL L P K P + +S D+
Sbjct: 167 IKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQ 226
Query: 281 WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK 340
WE++R I + +LG GQ+GEV+ G+W + VAVKTLK +M+ +FL+EA +MK ++
Sbjct: 227 WEIDRNSIQLLKRLGSGQFGEVWEGLWNN-TTPVAVKTLKPGSMDPNDFLREAQIMKNLR 285
Query: 341 HPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYL 400
HP L+QL VCTLE P YI+TE M +G+L +YL+ ++ + MA Q++S M YL
Sbjct: 286 HPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYL 345
Query: 401 EKKNFIHRDLAARNCLVGENHVVKVADFGLSRLM---TGDTYTAHAGAKFPIKWTAPESL 457
E +N+IHRDLAARN LVGE+++ KVADFGL+R+ D Y + K P+KWTAPE++
Sbjct: 346 ESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAI 405
Query: 458 AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYEL 517
N FSIKSDVW+FG+LL+EI TYG PY G+ +QV +L + YR+ QP CP + Y +
Sbjct: 406 RSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNI 465
Query: 518 MRACWKWSPADRPSFAETHQAFETMFH-DSSISE 550
M CW P +RP+F E F DSS S+
Sbjct: 466 MLECWNAEPKERPTFETLRWKLEDYFETDSSYSD 499
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 369 bits (946), Expect = e-101
Identities = 201/456 (44%), Positives = 281/456 (61%), Gaps = 14/456 (3%)
Query: 111 LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSL 168
LFVALYD+ A ++ LS KGEK ++L ++ G+W E RS G++PSNY+ PV+S+
Sbjct: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSE-GDWWEARSLTTGETGYIPSNYVAPVDSI 144
Query: 169 EKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR-----YEGRVYHYR 221
+ WY G + R AE L S N G+FL+RESE++ G S+S+R V HY+
Sbjct: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK 204
Query: 222 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVS-PIHDK 280
I +G Y+T ++F TL +LV H+S A GL L P K P + +S D
Sbjct: 205 IRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHK-GMPRLTDLSVKTKDV 263
Query: 281 WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK 340
WE+ R + + +LG GQ+GEV++G W + VA+KTLK TM E FL+EA +MK++K
Sbjct: 264 WEIPRESLQLIKRLGNGQFGEVWMGTWNG-NTKVAIKTLKPGTMSPESFLEEAQIMKKLK 322
Query: 341 HPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYL 400
H LVQL V + E P YIVTEYM G+LLD+L++ + L+ MA Q+++ M Y+
Sbjct: 323 HDKLVQLYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYI 381
Query: 401 EKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYN 460
E+ N+IHRDL + N LVG + K+ADFGL+RL+ + YTA GAKFPIKWTAPE+ Y
Sbjct: 382 ERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 441
Query: 461 TFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRA 520
F+IKSDVW+FG+LL E+ T G PYPG++ +V + +E+GYRM P+ CP ++ELM
Sbjct: 442 RFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIH 501
Query: 521 CWKWSPADRPSFAETHQAFETMFHDSSISEEVAEEL 556
CWK P +RP+F E F + + E L
Sbjct: 502 CWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 537
>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
Length = 543
Score = 368 bits (944), Expect = e-101
Identities = 202/455 (44%), Positives = 279/455 (61%), Gaps = 15/455 (3%)
Query: 111 LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSL 168
+FVALYD+ A LS KGE+ +++ N G+W E RS G++PSNY+ P +S+
Sbjct: 95 IFVALYDYEARTTEDLSFKKGERFQIIN-NTEGDWWEARSIATGKNGYIPSNYVAPADSI 153
Query: 169 EKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR-----YEGRVYHYR 221
+ WY G + R AE LL + N G FLVRESE++ G S+S+R V HY+
Sbjct: 154 QAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYK 213
Query: 222 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKW 281
I +G Y+T ++F TL +LV H++ ADGL L P KP G++ D W
Sbjct: 214 IRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTV-KPQTQGLAK--DAW 270
Query: 282 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 341
E+ R + ++ KLG G +GEV++G W + VA+KTLK TM E FL+EA +MK+++H
Sbjct: 271 EIPRESLRLEVKLGQGCFGEVWMGTWNG-TTKVAIKTLKPGTMMPEAFLQEAQIMKKLRH 329
Query: 342 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 401
LV L V + E P YIVTE+M G+LLD+L+E + + + L+ MA QI+ M Y+E
Sbjct: 330 DKLVPLYAVVS-EEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIE 388
Query: 402 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 461
+ N+IHRDL A N LVGEN V K+ADFGL+RL+ + YTA GAKFPIKWTAPE+ Y
Sbjct: 389 RMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 448
Query: 462 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 521
F+IKSDVW+FG+L E+ T G PYPG+ +V + +E+GYRM P+GCP ++ELM C
Sbjct: 449 FTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLC 508
Query: 522 WKWSPADRPSFAETHQAFETMFHDSSISEEVAEEL 556
WK P +RP+F E F + + E L
Sbjct: 509 WKKDPDERPTFEYIQSFLEDYFTATEPQYQPGENL 543
>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 364 bits (934), Expect = e-100
Identities = 213/523 (40%), Positives = 300/523 (57%), Gaps = 26/523 (4%)
Query: 30 PSGRRRDPAGRTTETGFNIFTQHDHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQAL 89
P ++ AG E F + DH+ G + K +S A H P + QA+
Sbjct: 11 PVATAKEDAG--LEGDFRSYGAADHY------GPDPTKARPASSFA-HIPNYSNFSSQAI 61
Query: 90 NEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVR 149
N S + G + LF+ALYD+ A ++ L+ TKGEK +L N G+W E R
Sbjct: 62 NPGFLDSG--TIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILN-NTEGDWWEAR 118
Query: 150 SKNG--QGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPG 205
S + G +PSNY+ PV+S++ WY G + R AE L S N G+FL+RESE++ G
Sbjct: 119 SLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKG 178
Query: 206 QLSISLR-----YEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLH 260
S+S+R V HY+I G Y+T +F+++ ELV H+ V DGL L
Sbjct: 179 AYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLI 238
Query: 261 YPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLK 320
P KP G++ D WE+ R+ IT++ +LG G +G+V++G W S VAVKTLK
Sbjct: 239 APCT-IMKPQTLGLAK--DAWEISRSSITLERRLGTGCFGDVWLGTWNG-STKVAVKTLK 294
Query: 321 EDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREE 380
TM + FL+EA VMK ++H LVQL V + E P YIVTE+M +G+LLD+L+ ++
Sbjct: 295 PGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVS-EEPIYIVTEFMCHGSLLDFLKNPEGQD 353
Query: 381 VTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYT 440
+ L+ MA Q++ M Y+E+ N+IHRDL A N LVGE K+ADFGL+RL+ D Y
Sbjct: 354 LRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYN 413
Query: 441 AHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEK 500
G+KFPIKWTAPE+ + F+IKSDVW+FG+LL E+ T G PYPG++ +V + +E+
Sbjct: 414 PCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQ 473
Query: 501 GYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMF 543
GY M P GCP +YE M W+ P +RP+F E F
Sbjct: 474 GYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYF 516
>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 364 bits (934), Expect = e-100
Identities = 213/523 (40%), Positives = 300/523 (57%), Gaps = 26/523 (4%)
Query: 30 PSGRRRDPAGRTTETGFNIFTQHDHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQAL 89
P ++ AG E F + DH+ G + K +S A H P + QA+
Sbjct: 11 PVATAKEDAG--LEGDFRSYGAADHY------GPDPTKARPASSFA-HIPNYSNFSSQAI 61
Query: 90 NEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVR 149
N S + G + LF+ALYD+ A ++ L+ TKGEK +L N G+W E R
Sbjct: 62 NPGFLDSG--TIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILN-NTEGDWWEAR 118
Query: 150 SKNG--QGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPG 205
S + G +PSNY+ PV+S++ WY G + R AE L S N G+FL+RESE++ G
Sbjct: 119 SLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKG 178
Query: 206 QLSISLR-----YEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLH 260
S+S+R V HY+I G Y+T +F+++ ELV H+ V DGL L
Sbjct: 179 AYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLI 238
Query: 261 YPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLK 320
P KP G++ D WE+ R+ IT++ +LG G +G+V++G W S VAVKTLK
Sbjct: 239 APCT-IMKPQTLGLAK--DAWEISRSSITLERRLGTGCFGDVWLGTWNG-STKVAVKTLK 294
Query: 321 EDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREE 380
TM + FL+EA VMK ++H LVQL V + E P YIVTE+M +G+LLD+L+ ++
Sbjct: 295 PGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVS-EEPIYIVTEFMCHGSLLDFLKNPEGQD 353
Query: 381 VTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYT 440
+ L+ MA Q++ M Y+E+ N+IHRDL A N LVGE K+ADFGL+RL+ D Y
Sbjct: 354 LRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYN 413
Query: 441 AHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEK 500
G+KFPIKWTAPE+ + F+IKSDVW+FG+LL E+ T G PYPG++ +V + +E+
Sbjct: 414 PCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQ 473
Query: 501 GYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMF 543
GY M P GCP +YE M W+ P +RP+F E F
Sbjct: 474 GYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYF 516
>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 364 bits (934), Expect = e-100
Identities = 213/523 (40%), Positives = 300/523 (57%), Gaps = 26/523 (4%)
Query: 30 PSGRRRDPAGRTTETGFNIFTQHDHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQAL 89
P ++ AG E F + DH+ G + K +S A H P + QA+
Sbjct: 11 PVATAKEDAG--LEGDFRSYGAADHY------GPDPTKARPASSFA-HIPNYSNFSSQAI 61
Query: 90 NEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVR 149
N S + G + LF+ALYD+ A ++ L+ TKGEK +L N G+W E R
Sbjct: 62 NPGFLDSG--TIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILN-NTEGDWWEAR 118
Query: 150 SKNG--QGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPG 205
S + G +PSNY+ PV+S++ WY G + R AE L S N G+FL+RESE++ G
Sbjct: 119 SLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKG 178
Query: 206 QLSISLR-----YEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLH 260
S+S+R V HY+I G Y+T +F+++ ELV H+ V DGL L
Sbjct: 179 AYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLI 238
Query: 261 YPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLK 320
P KP G++ D WE+ R+ IT++ +LG G +G+V++G W S VAVKTLK
Sbjct: 239 APCT-IMKPQTLGLAK--DAWEISRSSITLERRLGTGCFGDVWLGTWNG-STKVAVKTLK 294
Query: 321 EDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREE 380
TM + FL+EA VMK ++H LVQL V + E P YIVTE+M +G+LLD+L+ ++
Sbjct: 295 PGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVS-EEPIYIVTEFMCHGSLLDFLKNPEGQD 353
Query: 381 VTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYT 440
+ L+ MA Q++ M Y+E+ N+IHRDL A N LVGE K+ADFGL+RL+ D Y
Sbjct: 354 LRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYN 413
Query: 441 AHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEK 500
G+KFPIKWTAPE+ + F+IKSDVW+FG+LL E+ T G PYPG++ +V + +E+
Sbjct: 414 PCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQ 473
Query: 501 GYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMF 543
GY M P GCP +YE M W+ P +RP+F E F
Sbjct: 474 GYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYF 516
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 359 bits (922), Expect = 7e-99
Identities = 198/453 (43%), Positives = 280/453 (61%), Gaps = 13/453 (2%)
Query: 112 FVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ-GWVPSNYITPVNSLEK 170
FVALYD+ + + LS KGE+L+++ + W GQ G++PSNY+ P +S++
Sbjct: 89 FVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQA 148
Query: 171 HSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISL----RYEG-RVYHYRIN 223
WY G ++R +E LL + N G+FLVRESE++ G +S+ +G V HY+I
Sbjct: 149 EEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIR 208
Query: 224 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEM 283
G Y+T+ ++F++L +LV ++S ADGL L P +KP G++ D WE+
Sbjct: 209 KLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT-SKPQTQGLAK--DAWEI 265
Query: 284 ERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPN 343
R + ++ KLG G +GEV++G W + VA+KTLK TM E FL+EA VMK+++H
Sbjct: 266 PRESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEK 324
Query: 344 LVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK 403
LVQL V + E P YIVTEYM G+LLD+L+ + + L+ MA QI+S M Y+E+
Sbjct: 325 LVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383
Query: 404 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS 463
N++HRDL A N LVGEN V KVADFGL+RL+ + YTA GAKFPIKWTAPE+ Y F+
Sbjct: 384 NYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 443
Query: 464 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK 523
IKSDVW+FG+LL E+ T G PYPG+ +V D +E+GYRM P CP +++LM CW+
Sbjct: 444 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWR 503
Query: 524 WSPADRPSFAETHQAFETMFHDSSISEEVAEEL 556
P +RP+F E F + + E L
Sbjct: 504 KEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 359 bits (922), Expect = 7e-99
Identities = 198/453 (43%), Positives = 280/453 (61%), Gaps = 13/453 (2%)
Query: 112 FVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ-GWVPSNYITPVNSLEK 170
FVALYD+ + + LS KGE+L+++ + W GQ G++PSNY+ P +S++
Sbjct: 89 FVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQA 148
Query: 171 HSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISL----RYEG-RVYHYRIN 223
WY G ++R +E LL + N G+FLVRESE++ G +S+ +G V HY+I
Sbjct: 149 EEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIR 208
Query: 224 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEM 283
G Y+T+ ++F++L +LV ++S ADGL L P +KP G++ D WE+
Sbjct: 209 KLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT-SKPQTQGLAK--DAWEI 265
Query: 284 ERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPN 343
R + ++ KLG G +GEV++G W + VA+KTLK TM E FL+EA VMK+++H
Sbjct: 266 PRESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEK 324
Query: 344 LVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK 403
LVQL V + E P YIVTEYM G+LLD+L+ + + L+ MA QI+S M Y+E+
Sbjct: 325 LVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383
Query: 404 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS 463
N++HRDL A N LVGEN V KVADFGL+RL+ + YTA GAKFPIKWTAPE+ Y F+
Sbjct: 384 NYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 443
Query: 464 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK 523
IKSDVW+FG+LL E+ T G PYPG+ +V D +E+GYRM P CP +++LM CW+
Sbjct: 444 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWR 503
Query: 524 WSPADRPSFAETHQAFETMFHDSSISEEVAEEL 556
P +RP+F E F + + E L
Sbjct: 504 KEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 358 bits (920), Expect = 1e-98
Identities = 198/451 (43%), Positives = 281/451 (62%), Gaps = 21/451 (4%)
Query: 104 ATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNY 161
A+ NL +AL+ + S D L KGE+LR+L Q+GEW + +S +G++P N+
Sbjct: 58 ASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRIL--EQSGEWWKAQSLTTGQEGFIPFNF 115
Query: 162 ITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR----YEG 215
+ NSLE W+ +SR AE L + N GSFL+RESES+ G S+S+R +G
Sbjct: 116 VAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQG 175
Query: 216 RVY-HYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAP--KCNKPTVY 272
V HY+I +G Y++ F L ELV H++ +DGL T L P K KP
Sbjct: 176 EVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWW- 234
Query: 273 GVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKE 332
D+WE+ R + + +LG GQ+GEV++G + ++ VAVK+LK+ +M + FL E
Sbjct: 235 -----EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHT-KVAVKSLKQGSMSPDAFLAE 288
Query: 333 AAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQ 392
A +MK+++H LV+L V T EP YI+TEYM G+L+D+L+ + ++T LL MA Q
Sbjct: 289 ANLMKQLQHQRLVRLYAVVTQEP-IYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQ 347
Query: 393 ISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWT 452
I+ M ++E++N+IHRDL A N LV + K+ADFGL+RL+ + YTA GAKFPIKWT
Sbjct: 348 IAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWT 407
Query: 453 APESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPP 512
APE++ Y TF+IKSDVW+FG+LL EI T+G PYPG+ +V LE+GYRM +P+ CP
Sbjct: 408 APEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPE 467
Query: 513 KVYELMRACWKWSPADRPSFAETHQAFETMF 543
++Y+LMR CWK P DRP+F E F
Sbjct: 468 ELYQLMRLCWKERPEDRPTFDYLRSVLEDFF 498
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 358 bits (920), Expect = 1e-98
Identities = 198/451 (43%), Positives = 281/451 (62%), Gaps = 21/451 (4%)
Query: 104 ATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNY 161
A+ NL +AL+ + S D L KGE+LR+L Q+GEW + +S +G++P N+
Sbjct: 58 ASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRIL--EQSGEWWKAQSLTTGQEGFIPFNF 115
Query: 162 ITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR----YEG 215
+ NSLE W+ +SR AE L + N GSFL+RESES+ G S+S+R +G
Sbjct: 116 VAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQG 175
Query: 216 RVY-HYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAP--KCNKPTVY 272
V HY+I +G Y++ F L ELV H++ +DGL T L P K KP
Sbjct: 176 EVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWW- 234
Query: 273 GVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKE 332
D+WE+ R + + +LG GQ+GEV++G + ++ VAVK+LK+ +M + FL E
Sbjct: 235 -----EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHT-KVAVKSLKQGSMSPDAFLAE 288
Query: 333 AAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQ 392
A +MK+++H LV+L V T EP YI+TEYM G+L+D+L+ + ++T LL MA Q
Sbjct: 289 ANLMKQLQHQRLVRLYAVVTQEP-IYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQ 347
Query: 393 ISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWT 452
I+ M ++E++N+IHRDL A N LV + K+ADFGL+RL+ + YTA GAKFPIKWT
Sbjct: 348 IAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWT 407
Query: 453 APESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPP 512
APE++ Y TF+IKSDVW+FG+LL EI T+G PYPG+ +V LE+GYRM +P+ CP
Sbjct: 408 APEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPE 467
Query: 513 KVYELMRACWKWSPADRPSFAETHQAFETMF 543
++Y+LMR CWK P DRP+F E F
Sbjct: 468 ELYQLMRLCWKERPEDRPTFDYLRSVLEDFF 498
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 355 bits (910), Expect = 2e-97
Identities = 199/450 (44%), Positives = 281/450 (62%), Gaps = 23/450 (5%)
Query: 96 SSKENLLGATE--SDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--K 151
S N G E S+ + VALYD+ A LS KG+++ VL ++GEW + RS
Sbjct: 65 SHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVL--EESGEWWKARSLAT 122
Query: 152 NGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSI 209
+G++PSNY+ V+SLE W+ +SR AE L + N GSF++R+SE++ G S+
Sbjct: 123 RKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSL 182
Query: 210 SLR-YEGR----VYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYP-- 262
S+R Y+ R V HY+I T +G Y++ S FSTL ELV H+ DGL L P
Sbjct: 183 SVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCM 242
Query: 263 APKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKED 322
+ K KP D WE+ R + ++ KLG GQ+GEV++ + K++ VAVKT+K
Sbjct: 243 SSKPQKPWE------KDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHT-KVAVKTMKPG 295
Query: 323 TMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVT 382
+M VE FL EA VMK ++H LV+L V T EP YI+TE+M G+LLD+L+ +
Sbjct: 296 SMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEP-IYIITEFMAKGSLLDFLKSDEGSKQP 354
Query: 383 AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAH 442
L+ + QI+ M ++E++N+IHRDL A N LV + V K+ADFGL+R++ + YTA
Sbjct: 355 LPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAR 414
Query: 443 AGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGY 502
GAKFPIKWTAPE++ + +F+IKSDVW+FG+LL EI TYG PYPG+ +V LE+GY
Sbjct: 415 EGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGY 474
Query: 503 RMEQPEGCPPKVYELMRACWKWSPADRPSF 532
RM +PE CP ++Y +M CWK P +RP+F
Sbjct: 475 RMPRPENCPEELYNIMMRCWKNRPEERPTF 504
>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform B [Homo sapiens]
Length = 491
Score = 348 bits (893), Expect = 2e-95
Identities = 190/463 (41%), Positives = 281/463 (60%), Gaps = 20/463 (4%)
Query: 81 GCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYN 140
G D++ Q + E+ + E ++ VALY + + LS KGEK++VL
Sbjct: 16 GVDLKTQPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVL--E 73
Query: 141 QNGEWSEVRS--KNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFL 196
++GEW + +S +G++PSNY+ +N+LE W+ ++R AE L + N G+FL
Sbjct: 74 EHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFL 133
Query: 197 VRESESSPGQLSISLRYEGRVY-----HYRINTTADGKVYVTAESRFSTLAELVHHHSTV 251
+RESE+ G S+S+R V+ HY+I + +G Y++ F +++++ H+
Sbjct: 134 IRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQ 193
Query: 252 ADGLVTTLHYP--APKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKK 309
ADGL L +PK KP D WE+ R I + +LG GQ+GEV++G +
Sbjct: 194 ADGLCRRLEKACISPKPQKPWD------KDAWEIPRESIKLVKRLGAGQFGEVWMGYYNN 247
Query: 310 YSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNL 369
S VAVKTLK TM V+ FL+EA +MK ++H LV+L V T E P YI+TEYM G+L
Sbjct: 248 -STKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSL 306
Query: 370 LDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFG 429
LD+L+ +V L+ + QI+ M Y+E+KN+IHRDL A N LV E+ + K+ADFG
Sbjct: 307 LDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFG 366
Query: 430 LSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGI 489
L+R++ + YTA GAKFPIKWTAPE++ + F+IKSDVW+FG+LL+EI TYG PYPG
Sbjct: 367 LARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGR 426
Query: 490 DLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF 532
+ V L +GYRM + E CP ++Y++M+ CWK +RP+F
Sbjct: 427 TNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTF 469
>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform A [Homo sapiens]
Length = 512
Score = 347 bits (890), Expect = 4e-95
Identities = 186/438 (42%), Positives = 272/438 (62%), Gaps = 20/438 (4%)
Query: 106 ESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYIT 163
E ++ VALY + + LS KGEK++VL ++GEW + +S +G++PSNY+
Sbjct: 62 EEQGDIVVALYPYDGIHPDDLSFKKGEKMKVL--EEHGEWWKAKSLLTKKEGFIPSNYVA 119
Query: 164 PVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYEGRVY--- 218
+N+LE W+ ++R AE L + N G+FL+RESE+ G S+S+R V+
Sbjct: 120 KLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDV 179
Query: 219 --HYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYP--APKCNKPTVYGV 274
HY+I + +G Y++ F +++++ H+ ADGL L +PK KP
Sbjct: 180 IKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWD--- 236
Query: 275 SPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAA 334
D WE+ R I + +LG GQ+GEV++G + S VAVKTLK TM V+ FL+EA
Sbjct: 237 ---KDAWEIPRESIKLVKRLGAGQFGEVWMGYYNN-STKVAVKTLKPGTMSVQAFLEEAN 292
Query: 335 VMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQIS 394
+MK ++H LV+L V T E P YI+TEYM G+LLD+L+ +V L+ + QI+
Sbjct: 293 LMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIA 352
Query: 395 SAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAP 454
M Y+E+KN+IHRDL A N LV E+ + K+ADFGL+R++ + YTA GAKFPIKWTAP
Sbjct: 353 EGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAP 412
Query: 455 ESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKV 514
E++ + F+IKSDVW+FG+LL+EI TYG PYPG + V L +GYRM + E CP ++
Sbjct: 413 EAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDEL 472
Query: 515 YELMRACWKWSPADRPSF 532
Y++M+ CWK +RP+F
Sbjct: 473 YDIMKMCWKEKAEERPTF 490
>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
Length = 505
Score = 344 bits (883), Expect = 2e-94
Identities = 195/447 (43%), Positives = 270/447 (60%), Gaps = 18/447 (4%)
Query: 106 ESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYIT 163
+ D + VALYD+ A D L + KGEKL+VL G+W RS +G+VPSN++
Sbjct: 57 DEDKHFVVALYDYTAMNDRDLQMLKGEKLQVL--KGTGDWWLARSLVTGREGYVPSNFVA 114
Query: 164 PVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR---YEGR-V 217
V SLE W+ R AE L + IN GSFL+RESE++ G S+S++ +G +
Sbjct: 115 RVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELI 174
Query: 218 YHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPI 277
HY+I +G Y++ F +L LV H+S DGL L P C +P
Sbjct: 175 KHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLP---CVRPAPQNPWA- 230
Query: 278 HDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMK 337
D+WE+ R + + KLG GQ+GEV++G +K ++ VA+KTLKE TM E FL EA VMK
Sbjct: 231 QDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKN-NMKVAIKTLKEGTMSPEAFLGEANVMK 289
Query: 338 EIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAM 397
++H LV+L V T EP YIVTEYM G LLD+L+ ++ L+ M+ QI+ M
Sbjct: 290 ALQHERLVRLYAVVTKEP-IYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGM 348
Query: 398 EYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL 457
Y+E+ N IHRDL A N LV E K+ADFGL+R++ + YTA GAKFPIKWTAPE++
Sbjct: 349 AYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSE-YTAQEGAKFPIKWTAPEAI 407
Query: 458 AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYE- 516
+ F+IK+DVW+FGVLL E+ TYG PYPG+ +V LE+GYRM +P+ CPP++Y
Sbjct: 408 HFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRG 467
Query: 517 LMRACWKWSPADRPSFAETHQAFETMF 543
++ CW+ P +RP+F E +
Sbjct: 468 VIAECWRSRPEERPTFEFLQSVLEDFY 494
>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
Length = 631
Score = 332 bits (851), Expect = 1e-90
Identities = 185/443 (41%), Positives = 272/443 (61%), Gaps = 20/443 (4%)
Query: 106 ESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYIT- 163
++ + VA+YDF A+ + L + +G++ +L N + W R K G +G++PSNY+T
Sbjct: 178 DNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKN-DVHWWRARDKYGNEGYIPSNYVTG 236
Query: 164 -PVNSLEKHSWYHGPVSRSAAEYLLSSLIN-GSFLVRESESSPGQLSISL--RYEG---- 215
N+L+++ WY ++RS AE LL S G F+VR+S S PG ++SL ++ G
Sbjct: 237 KKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSS 295
Query: 216 --RVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNK--PTV 271
R YH + TT+ K Y+ + F ++ E++ +H A GLVT L YP K PT
Sbjct: 296 GFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTT 355
Query: 272 YGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLK 331
G S ++KWE+ +++T +LG G +G V +G W+ VA+K ++E M E+F++
Sbjct: 356 AGFS--YEKWEINPSELTFMRELGSGLFGVVRLGKWRA-QYKVAIKAIREGAMCEEDFIE 412
Query: 332 EAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMAT 391
EA VM ++ HP LVQL GVCT + P YIVTE+M G LL++LR+ + + VLL M
Sbjct: 413 EAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQ-RQGHFSRDVLLSMCQ 471
Query: 392 QISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKW 451
+ MEYLE+ +FIHRDLAARNCLV E VVKV+DFG++R + D YT+ +GAKFP+KW
Sbjct: 472 DVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKW 531
Query: 452 TAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCP 511
PE Y+ FS KSDVW+FGVL+WE+ T G P+ +V ++ +G+R+ QP+
Sbjct: 532 CPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLAS 591
Query: 512 PKVYELMRACWKWSPADRPSFAE 534
VYE+M CW+ P RPSF +
Sbjct: 592 NYVYEVMLRCWQEKPEGRPSFED 614
>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
Length = 659
Score = 331 bits (848), Expect = 3e-90
Identities = 182/431 (42%), Positives = 261/431 (60%), Gaps = 17/431 (3%)
Query: 113 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ-GWVPSNYITPV-NSLEK 170
VALYD++ N L + KG++ +L N W R KNGQ G++PSNY+T +S+E
Sbjct: 220 VALYDYMPMNANDLQLRKGDEYFILE-ESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEM 278
Query: 171 HSWYHGPVSRSAAEYLLSSL-INGSFLVRESESSPGQLSISLRY------EGRVYHYRIN 223
+ WY ++RS AE LL G F+VR+S S G+ ++S+ +G + HY +
Sbjct: 279 YEWYSKHMTRSQAEQLLKQEGKEGGFIVRDS-SKAGKYTVSVFAKSTGDPQGVIRHYVVC 337
Query: 224 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNK--PTVYGVSPIHDKW 281
+T + Y+ + FST+ EL+++H + GL++ L YP + NK P+ G+ + W
Sbjct: 338 STPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLG--YGSW 395
Query: 282 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 341
E++ D+T +LG GQ+G V G W+ VA+K +KE +M +EF++EA VM + H
Sbjct: 396 EIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIKEGSMSEDEFIEEAKVMMNLSH 454
Query: 342 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 401
LVQL GVCT + P +I+TEYM G LL+YLRE R LL M + AMEYLE
Sbjct: 455 EKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREM-RHRFQTQQLLEMCKDVCEAMEYLE 513
Query: 402 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 461
K F+HRDLAARNCLV + VVKV+DFGLSR + D YT+ G+KFP++W+ PE L Y+
Sbjct: 514 SKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSK 573
Query: 462 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 521
FS KSD+WAFGVL+WEI + G PY S+ + + +G R+ +P KVY +M +C
Sbjct: 574 FSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSC 633
Query: 522 WKWSPADRPSF 532
W +RP+F
Sbjct: 634 WHEKADERPTF 644
>gi|148596974 TXK tyrosine kinase [Homo sapiens]
Length = 527
Score = 322 bits (825), Expect = 1e-87
Identities = 173/437 (39%), Positives = 261/437 (59%), Gaps = 18/437 (4%)
Query: 114 ALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYITP--VNSLEK 170
ALYDF+ L++ + E+ +L N W + R + G +G +PSNY+T + +LE
Sbjct: 89 ALYDFLPREPCNLALRRAEEYLILE-KYNPHWWKARDRLGNEGLIPSNYVTENKITNLEI 147
Query: 171 HSWYHGPVSRSAAEYLL-SSLINGSFLVRESESSPGQLSISL------RYEGRVYHYRIN 223
+ WYH ++R+ AE+LL G+F+VR+S G +IS+ E + HY+I
Sbjct: 148 YEWYHRNITRNQAEHLLRQESKEGAFIVRDSRHL-GSYTISVFMGARRSTEAAIKHYQIK 206
Query: 224 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNK--PTVYGVSPIHDKW 281
G+ YV F ++ EL+ +H A GL+T L YP P G S ++KW
Sbjct: 207 KNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFS--YEKW 264
Query: 282 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 341
E++ +++ ++G GQ+G V++G W+ + + VA+K + E +M E+F++EA VM ++ H
Sbjct: 265 EIDPSELAFIKEIGSGQFGVVHLGEWRSH-IQVAIKAINEGSMSEEDFIEEAKVMMKLSH 323
Query: 342 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 401
LVQL GVC P YIVTE+M G LL+YLRE N+ ++ +LL + I MEYLE
Sbjct: 324 SKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRE-NKGKLRKEMLLSVCQDICEGMEYLE 382
Query: 402 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 461
+ +IHRDLAARNCLV +VK++DFG++R + D Y + GAKFPIKW+ PE +N
Sbjct: 383 RNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNK 442
Query: 462 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 521
+S KSDVW+FGVL+WE+ T G P+ QV + + +G+R+ +P P +YE+M +C
Sbjct: 443 YSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSC 502
Query: 522 WKWSPADRPSFAETHQA 538
W P RP+FAE +A
Sbjct: 503 WHEKPEGRPTFAELLRA 519
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 316 bits (810), Expect = 7e-86
Identities = 178/437 (40%), Positives = 257/437 (58%), Gaps = 19/437 (4%)
Query: 113 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYITPVNSLEKH 171
+A Y+F + + L KG+ L ++ ++ W + ++K G +G +P+NY+ ++
Sbjct: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAG 74
Query: 172 S------WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 225
+ W+HG ++R AE LL G FLVRES + PG ++ + +G+V HYRI
Sbjct: 75 TKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYH 134
Query: 226 ADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDK-WEME 284
A K+ + E F L +LV H+++ ADGL T L PK + TV + W +
Sbjct: 135 AS-KLSIDEEVYFENLMQLVEHYTSDADGLCTRLI--KPKVMEGTVAAQDEFYRSGWALN 191
Query: 285 RTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNL 344
++ + +G G++G+V +G ++ VAVK +K D + FL EA+VM +++H NL
Sbjct: 192 MKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDAT-AQAFLAEASVMTQLRHSNL 248
Query: 345 VQLLGVCTLEPP-FYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK 403
VQLLGV E YIVTEYM G+L+DYLR R + LL + + AMEYLE
Sbjct: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308
Query: 404 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS 463
NF+HRDLAARN LV E++V KV+DFGL++ + T K P+KWTAPE+L FS
Sbjct: 309 NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEALREKKFS 364
Query: 464 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK 523
KSDVW+FG+LLWEI ++G PYP I L V +EKGY+M+ P+GCPP VYE+M+ CW
Sbjct: 365 TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWH 424
Query: 524 WSPADRPSFAETHQAFE 540
A RPSF + + E
Sbjct: 425 LDAAMRPSFLQLREQLE 441
>gi|4758078 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 316 bits (810), Expect = 7e-86
Identities = 178/437 (40%), Positives = 257/437 (58%), Gaps = 19/437 (4%)
Query: 113 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYITPVNSLEKH 171
+A Y+F + + L KG+ L ++ ++ W + ++K G +G +P+NY+ ++
Sbjct: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAG 74
Query: 172 S------WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 225
+ W+HG ++R AE LL G FLVRES + PG ++ + +G+V HYRI
Sbjct: 75 TKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYH 134
Query: 226 ADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDK-WEME 284
A K+ + E F L +LV H+++ ADGL T L PK + TV + W +
Sbjct: 135 AS-KLSIDEEVYFENLMQLVEHYTSDADGLCTRLI--KPKVMEGTVAAQDEFYRSGWALN 191
Query: 285 RTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNL 344
++ + +G G++G+V +G ++ VAVK +K D + FL EA+VM +++H NL
Sbjct: 192 MKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDAT-AQAFLAEASVMTQLRHSNL 248
Query: 345 VQLLGVCTLEPP-FYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK 403
VQLLGV E YIVTEYM G+L+DYLR R + LL + + AMEYLE
Sbjct: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308
Query: 404 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS 463
NF+HRDLAARN LV E++V KV+DFGL++ + T K P+KWTAPE+L FS
Sbjct: 309 NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEALREKKFS 364
Query: 464 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK 523
KSDVW+FG+LLWEI ++G PYP I L V +EKGY+M+ P+GCPP VYE+M+ CW
Sbjct: 365 TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWH 424
Query: 524 WSPADRPSFAETHQAFE 540
A RPSF + + E
Sbjct: 425 LDAAMRPSFLQLREQLE 441
>gi|18250298 src-related kinase lacking C-terminal regulatory
tyrosine and N-terminal myristylation sites [Homo
sapiens]
Length = 488
Score = 305 bits (781), Expect = 2e-82
Identities = 173/432 (40%), Positives = 247/432 (57%), Gaps = 17/432 (3%)
Query: 109 PNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ---GWVPSNYITPV 165
P LF+ALYDF A LS+ +G++L L + G + R +GQ G VP ++
Sbjct: 53 PQLFLALYDFTARCGGELSVRRGDRLCAL--EEGGGYIFARRLSGQPSAGLVPITHVAKA 110
Query: 166 N--SLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYEGRVYHYR 221
+ +L WY VSR+ A+ LL S N G+FL+R SESS G S+S+R + +V HYR
Sbjct: 111 SPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYR 170
Query: 222 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKW 281
++ ADG +Y+ F L EL+ ++ + L +P + +P D W
Sbjct: 171 VSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLL-------QPCMPQKAPRQDVW 223
Query: 282 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 341
E ++ + KLG G +GEV+ G+W SL VA+K +K M++ + KE +K ++H
Sbjct: 224 ERPHSEFALGRKLGEGYFGEVWEGLWLG-SLPVAIKVIKSANMKLTDLAKEIQTLKGLRH 282
Query: 342 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 401
L++L VC+ P YIVTE M GNL +L + LL A Q++ M YLE
Sbjct: 283 ERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLE 342
Query: 402 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 461
++ +HRDLAARN LV + KVADFGL+RL+ D Y+ + +K P+KWTAPE+ Y
Sbjct: 343 EQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRV 402
Query: 462 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 521
FS KSDVW+FGVLL E+ TYG PY G+ + + +GYR+ +P CP +VY LM C
Sbjct: 403 FSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLEC 462
Query: 522 WKWSPADRPSFA 533
W+ SP +RPSFA
Sbjct: 463 WRSSPEERPSFA 474
>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
Length = 620
Score = 305 bits (780), Expect = 2e-82
Identities = 174/471 (36%), Positives = 271/471 (57%), Gaps = 24/471 (5%)
Query: 81 GC---DVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVL 137
GC D A + + + ++N E + + +ALYD+ + L++ + E+ +L
Sbjct: 142 GCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALYDYQTNDPQELALRRNEEYCLL 201
Query: 138 GYNQNGEWSEVRSKNG-QGWVPSNYITPV--NSLEKHSWYHGPVSRSAAE-YLLSSLING 193
++ W V+ +NG +G+VPS+Y+ N+LE + WY+ +SR AE LL + G
Sbjct: 202 DSSEI-HWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKEG 260
Query: 194 SFLVRESESSPGQLSISLRYEGRVY-------HYRINTTADG--KVYVTAESRFSTLAEL 244
+F+VR+S ++ G ++S+ + V HY I T D + YV + F ++ L
Sbjct: 261 AFMVRDSRTA-GTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLL 319
Query: 245 VHHHSTVADGLVTTLHYPA--PKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEV 302
+++H GLVT L YP + P G+ + KW ++ +++T ++G GQ+G V
Sbjct: 320 INYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLR--YGKWVIDPSELTFVQEIGSGQFGLV 377
Query: 303 YVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTE 362
++G W VA+KT++E M E+F++EA VM ++ HP LVQL GVC + P +V E
Sbjct: 378 HLGYWLNKD-KVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFE 436
Query: 363 YMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHV 422
+M +G L DYLR R A LL M + M YLE+ IHRDLAARNCLVGEN V
Sbjct: 437 FMEHGCLSDYLRT-QRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQV 495
Query: 423 VKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYG 482
+KV+DFG++R + D YT+ G KFP+KW +PE +++ +S KSDVW+FGVL+WE+ + G
Sbjct: 496 IKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEG 555
Query: 483 MSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFA 533
PY S+V + + G+R+ +P VY++M CWK P DRP+F+
Sbjct: 556 KIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFS 606
>gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]
Length = 482
Score = 295 bits (754), Expect = 2e-79
Identities = 178/450 (39%), Positives = 246/450 (54%), Gaps = 57/450 (12%)
Query: 111 LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSL 168
LFVALYD+ A ++ LS KGEK ++L ++ G+W E RS G++PSNY+ PV+S+
Sbjct: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSE-GDWWEARSLTTGETGYIPSNYVAPVDSI 144
Query: 169 EKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYEGRVYHYRINTTA 226
+ WY G + R AE L S N G+FL+RESE++ G Y I
Sbjct: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKG-----------AYSLSIRDWD 193
Query: 227 DGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERT 286
D K D + HY K + Y I + + E
Sbjct: 194 DMK----------------------GDHVK---HYKIRKLDNGGYY----ITTRAQFETL 224
Query: 287 DITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ 346
++H Y G W + VA+KTLK TM E FL+EA +MK++KH LVQ
Sbjct: 225 QQLVQH----------YSGTWNG-NTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQ 273
Query: 347 LLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFI 406
L V + E P YIVTEYM G+LLD+L++ + L+ MA Q+++ M Y+E+ N+I
Sbjct: 274 LYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYI 332
Query: 407 HRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKS 466
HRDL + N LVG + K+ADFGL+RL+ + YTA GAKFPIKWTAPE+ Y F+IKS
Sbjct: 333 HRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 392
Query: 467 DVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSP 526
DVW+FG+LL E+ T G PYPG++ +V + +E+GYRM P+ CP ++ELM CWK P
Sbjct: 393 DVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDP 452
Query: 527 ADRPSFAETHQAFETMFHDSSISEEVAEEL 556
+RP+F E F + + E L
Sbjct: 453 EERPTFEYLQSFLEDYFTATEPQYQPGENL 482
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.130 0.385
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,436,648
Number of Sequences: 37866
Number of extensions: 2693123
Number of successful extensions: 16673
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 724
Number of HSP's successfully gapped in prelim test: 595
Number of HSP's that attempted gapping in prelim test: 12227
Number of HSP's gapped (non-prelim): 3063
length of query: 1182
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1069
effective length of database: 13,968,660
effective search space: 14932497540
effective search space used: 14932497540
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.