Guide to the Human Genome
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Search of human proteins with 63252863

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|63252863 BTB (POZ) domain containing 12 [Homo sapiens]
         (1834 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|63252863 BTB (POZ) domain containing 12 [Homo sapiens]            3693   0.0  
gi|132626688 mediator of DNA-damage checkpoint 1 [Homo sapiens]        55   6e-07
gi|149158690 HLA-B associated transcript-2 [Homo sapiens]              55   8e-07
gi|115430108 rho-related BTB domain containing 3 [Homo sapiens]        50   3e-05
gi|150418009 transforming, acidic coiled-coil containing protein...    49   3e-05
gi|45827755 transforming, acidic coiled-coil containing protein ...    49   3e-05
gi|45827753 transforming, acidic coiled-coil containing protein ...    49   3e-05
gi|11119414 transforming, acidic coiled-coil containing protein ...    49   3e-05
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     49   4e-05
gi|40807477 retinoic acid induced 1 [Homo sapiens]                     49   4e-05
gi|19924099 synapsin I isoform Ia [Homo sapiens]                       48   1e-04
gi|91982772 mucin 17 [Homo sapiens]                                    48   1e-04
gi|164419758 bromodomain containing 2 [Homo sapiens]                   47   1e-04
gi|4826806 bromodomain containing 2 [Homo sapiens]                     47   1e-04
gi|46370071 GRB2-associated binding protein 1 isoform a [Homo sa...    47   2e-04
gi|4557445 regulator of chromosome condensation and BTB domain c...    46   3e-04
gi|211904190 hypothetical protein LOC149478 [Homo sapiens]             45   6e-04
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                   45   8e-04
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                   45   8e-04
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                   45   8e-04
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                    45   8e-04
gi|95147555 microtubule-associated protein 1A [Homo sapiens]           44   0.001
gi|19924097 synapsin I isoform Ib [Homo sapiens]                       44   0.001
gi|92091572 dedicator of cytokinesis 4 [Homo sapiens]                  44   0.001
gi|4507161 SRY-box 11 [Homo sapiens]                                   44   0.001
gi|239743602 PREDICTED: hypothetical protein XP_002342903 [Homo ...    44   0.002
gi|239743600 PREDICTED: hypothetical protein XP_002342902 [Homo ...    44   0.002
gi|239743598 PREDICTED: hypothetical protein XP_002342901 [Homo ...    44   0.002
gi|239743596 PREDICTED: hypothetical protein XP_002342900 [Homo ...    44   0.002
gi|155030232 proline, glutamic acid and leucine rich protein 1 [...    44   0.002

>gi|63252863 BTB (POZ) domain containing 12 [Homo sapiens]
          Length = 1834

 Score = 3693 bits (9577), Expect = 0.0
 Identities = 1834/1834 (100%), Positives = 1834/1834 (100%)

Query: 1    MKLSVNEAQLGFYLGSLSHLSACPGIDPRSSEDQPESLKTGQMMDESDEDFKELCASFFQ 60
            MKLSVNEAQLGFYLGSLSHLSACPGIDPRSSEDQPESLKTGQMMDESDEDFKELCASFFQ
Sbjct: 1    MKLSVNEAQLGFYLGSLSHLSACPGIDPRSSEDQPESLKTGQMMDESDEDFKELCASFFQ 60

Query: 61   RVKKHGIKEVSGERKTQKAASNGTQIRSKLKRTKQTATKTKTLQGPAEKKPPSGSQAPRT 120
            RVKKHGIKEVSGERKTQKAASNGTQIRSKLKRTKQTATKTKTLQGPAEKKPPSGSQAPRT
Sbjct: 61   RVKKHGIKEVSGERKTQKAASNGTQIRSKLKRTKQTATKTKTLQGPAEKKPPSGSQAPRT 120

Query: 121  KKQRVTKWQASEPAHSVNGEGGVLASAPDPPVLRETAQNTQTGNQQEPSPNLSREKTREN 180
            KKQRVTKWQASEPAHSVNGEGGVLASAPDPPVLRETAQNTQTGNQQEPSPNLSREKTREN
Sbjct: 121  KKQRVTKWQASEPAHSVNGEGGVLASAPDPPVLRETAQNTQTGNQQEPSPNLSREKTREN 180

Query: 181  VPNSDSQPPPSCLTTAVPSPSKPRTAQLVLQRMQQFKRADPERLRHASEECSLEAAREEN 240
            VPNSDSQPPPSCLTTAVPSPSKPRTAQLVLQRMQQFKRADPERLRHASEECSLEAAREEN
Sbjct: 181  VPNSDSQPPPSCLTTAVPSPSKPRTAQLVLQRMQQFKRADPERLRHASEECSLEAAREEN 240

Query: 241  VPKDPQEEMMAGNVYGLGPPAPESDAAVALTLQQEFARVGASAHDDSLEEKGLFFCQICQ 300
            VPKDPQEEMMAGNVYGLGPPAPESDAAVALTLQQEFARVGASAHDDSLEEKGLFFCQICQ
Sbjct: 241  VPKDPQEEMMAGNVYGLGPPAPESDAAVALTLQQEFARVGASAHDDSLEEKGLFFCQICQ 300

Query: 301  KNLSAMNVTRREQHVNRCLDEAEKTLRPSVPQIPECPICGKPFLTLKSRTSHLKQCAVKM 360
            KNLSAMNVTRREQHVNRCLDEAEKTLRPSVPQIPECPICGKPFLTLKSRTSHLKQCAVKM
Sbjct: 301  KNLSAMNVTRREQHVNRCLDEAEKTLRPSVPQIPECPICGKPFLTLKSRTSHLKQCAVKM 360

Query: 361  EVGPQLLLQAVRLQTAQPEGSSSPPMFSFSDHSRGLKRRGPTSKKEPRKRRKVDEAPSED 420
            EVGPQLLLQAVRLQTAQPEGSSSPPMFSFSDHSRGLKRRGPTSKKEPRKRRKVDEAPSED
Sbjct: 361  EVGPQLLLQAVRLQTAQPEGSSSPPMFSFSDHSRGLKRRGPTSKKEPRKRRKVDEAPSED 420

Query: 421  LLVAMALSRSEMEPGAAVPALRLESAFSERIRPEAENKSRKKKPPVSPPLLLVQDSETTG 480
            LLVAMALSRSEMEPGAAVPALRLESAFSERIRPEAENKSRKKKPPVSPPLLLVQDSETTG
Sbjct: 421  LLVAMALSRSEMEPGAAVPALRLESAFSERIRPEAENKSRKKKPPVSPPLLLVQDSETTG 480

Query: 481  RQIEDRVALLLSEEVELSSTPPLPASRILKEGWERAGQCPPPPERKQSFLWEGSALTGAW 540
            RQIEDRVALLLSEEVELSSTPPLPASRILKEGWERAGQCPPPPERKQSFLWEGSALTGAW
Sbjct: 481  RQIEDRVALLLSEEVELSSTPPLPASRILKEGWERAGQCPPPPERKQSFLWEGSALTGAW 540

Query: 541  AMEDFYTARLVPPLVPQRPAQGLMQEPVPPLVPPEHSELSERRSPALHGTPTAGCGSRGP 600
            AMEDFYTARLVPPLVPQRPAQGLMQEPVPPLVPPEHSELSERRSPALHGTPTAGCGSRGP
Sbjct: 541  AMEDFYTARLVPPLVPQRPAQGLMQEPVPPLVPPEHSELSERRSPALHGTPTAGCGSRGP 600

Query: 601  SPSASQREHQALQDLVDLAREGLSASPWPGSGGLAGSEGTAGLDVVPGGLPLTGFVVPSQ 660
            SPSASQREHQALQDLVDLAREGLSASPWPGSGGLAGSEGTAGLDVVPGGLPLTGFVVPSQ
Sbjct: 601  SPSASQREHQALQDLVDLAREGLSASPWPGSGGLAGSEGTAGLDVVPGGLPLTGFVVPSQ 660

Query: 661  DKHPDRGGRTLLSLGLLVADFGAMVNNPHLSDVQFQTDSGEVLYAHKFVLYARCPLLIQY 720
            DKHPDRGGRTLLSLGLLVADFGAMVNNPHLSDVQFQTDSGEVLYAHKFVLYARCPLLIQY
Sbjct: 661  DKHPDRGGRTLLSLGLLVADFGAMVNNPHLSDVQFQTDSGEVLYAHKFVLYARCPLLIQY 720

Query: 721  VNNEGFSAVEDGVLTQRVLLGDVSTEAARTFLHYLYTADTGLPPGLSSELSSLAHRFGVS 780
            VNNEGFSAVEDGVLTQRVLLGDVSTEAARTFLHYLYTADTGLPPGLSSELSSLAHRFGVS
Sbjct: 721  VNNEGFSAVEDGVLTQRVLLGDVSTEAARTFLHYLYTADTGLPPGLSSELSSLAHRFGVS 780

Query: 781  ELVHLCEQVPIATDSEGKPWEEKEAENCESRAENFQELLRSMWADEEEEAETLLKSKDHE 840
            ELVHLCEQVPIATDSEGKPWEEKEAENCESRAENFQELLRSMWADEEEEAETLLKSKDHE
Sbjct: 781  ELVHLCEQVPIATDSEGKPWEEKEAENCESRAENFQELLRSMWADEEEEAETLLKSKDHE 840

Query: 841  EDQENVNEAEMEEIYEFAATQRKLLQEERAAGAGEDADWLEGGSPVSGQLLAGVQVQKQW 900
            EDQENVNEAEMEEIYEFAATQRKLLQEERAAGAGEDADWLEGGSPVSGQLLAGVQVQKQW
Sbjct: 841  EDQENVNEAEMEEIYEFAATQRKLLQEERAAGAGEDADWLEGGSPVSGQLLAGVQVQKQW 900

Query: 901  DKVEEMEPLEPGRDEAATTWEKMGQCALPPPQGQHSGARGAEAPEQEAPEEALGHSSCSS 960
            DKVEEMEPLEPGRDEAATTWEKMGQCALPPPQGQHSGARGAEAPEQEAPEEALGHSSCSS
Sbjct: 901  DKVEEMEPLEPGRDEAATTWEKMGQCALPPPQGQHSGARGAEAPEQEAPEEALGHSSCSS 960

Query: 961  PSRDCQAERKEGSLPHSDDAGDYEQLFSSTQGEISEPSQITSEPEEQSGAVRERGLEVSH 1020
            PSRDCQAERKEGSLPHSDDAGDYEQLFSSTQGEISEPSQITSEPEEQSGAVRERGLEVSH
Sbjct: 961  PSRDCQAERKEGSLPHSDDAGDYEQLFSSTQGEISEPSQITSEPEEQSGAVRERGLEVSH 1020

Query: 1021 RLAPWQASPPHPCRFLLGPPQGGSPRGSHHTSGSSLSTPRSRGGTSQVGSPTLLSPAVPS 1080
            RLAPWQASPPHPCRFLLGPPQGGSPRGSHHTSGSSLSTPRSRGGTSQVGSPTLLSPAVPS
Sbjct: 1021 RLAPWQASPPHPCRFLLGPPQGGSPRGSHHTSGSSLSTPRSRGGTSQVGSPTLLSPAVPS 1080

Query: 1081 KQKRDRSILTLSKEPGHQKGKERRSVLECRNKGVLMFPEKSPSIDLTQSNPDHSSSRSQK 1140
            KQKRDRSILTLSKEPGHQKGKERRSVLECRNKGVLMFPEKSPSIDLTQSNPDHSSSRSQK
Sbjct: 1081 KQKRDRSILTLSKEPGHQKGKERRSVLECRNKGVLMFPEKSPSIDLTQSNPDHSSSRSQK 1140

Query: 1141 SSSKLNEEDEVILLLDSDEELELEQTKMKSISSDPLEEKKALEISPRSCELFSIIDVDAD 1200
            SSSKLNEEDEVILLLDSDEELELEQTKMKSISSDPLEEKKALEISPRSCELFSIIDVDAD
Sbjct: 1141 SSSKLNEEDEVILLLDSDEELELEQTKMKSISSDPLEEKKALEISPRSCELFSIIDVDAD 1200

Query: 1201 QEPSQSPPRSEAVLQQEDEGALPENRGSLGRRGAPWLFCDRESSPSEASTTDTSWLVPAT 1260
            QEPSQSPPRSEAVLQQEDEGALPENRGSLGRRGAPWLFCDRESSPSEASTTDTSWLVPAT
Sbjct: 1201 QEPSQSPPRSEAVLQQEDEGALPENRGSLGRRGAPWLFCDRESSPSEASTTDTSWLVPAT 1260

Query: 1261 PLASRSRDCSSQTQISSLRSGLAVQAVTQHTPRASVGNREGNEVAQKFSVIRPQTPPPQT 1320
            PLASRSRDCSSQTQISSLRSGLAVQAVTQHTPRASVGNREGNEVAQKFSVIRPQTPPPQT
Sbjct: 1261 PLASRSRDCSSQTQISSLRSGLAVQAVTQHTPRASVGNREGNEVAQKFSVIRPQTPPPQT 1320

Query: 1321 PSSCLTPVSPGTSDGRRQGHRSPSRPHPGGHPHSSPLAPHPISGDRAHFSRRFLKHSPPG 1380
            PSSCLTPVSPGTSDGRRQGHRSPSRPHPGGHPHSSPLAPHPISGDRAHFSRRFLKHSPPG
Sbjct: 1321 PSSCLTPVSPGTSDGRRQGHRSPSRPHPGGHPHSSPLAPHPISGDRAHFSRRFLKHSPPG 1380

Query: 1381 PSFLNQTPAGEVVEVGDSDDEQEVASHQANRSPPLDSDPPIPIDDCCWHMEPLSPIPIDH 1440
            PSFLNQTPAGEVVEVGDSDDEQEVASHQANRSPPLDSDPPIPIDDCCWHMEPLSPIPIDH
Sbjct: 1381 PSFLNQTPAGEVVEVGDSDDEQEVASHQANRSPPLDSDPPIPIDDCCWHMEPLSPIPIDH 1440

Query: 1441 WNLERTGPLSTSSPSRRMNEAADSRDCRSPGLLDTTPIRGSCTTQRKLQEKSSGAGSLGN 1500
            WNLERTGPLSTSSPSRRMNEAADSRDCRSPGLLDTTPIRGSCTTQRKLQEKSSGAGSLGN
Sbjct: 1441 WNLERTGPLSTSSPSRRMNEAADSRDCRSPGLLDTTPIRGSCTTQRKLQEKSSGAGSLGN 1500

Query: 1501 SRPSFLNSALWDVWDGEEQRPPETPPPAQMPSAGGAQKPEGLETPKGANRKKNLPPKVPI 1560
            SRPSFLNSALWDVWDGEEQRPPETPPPAQMPSAGGAQKPEGLETPKGANRKKNLPPKVPI
Sbjct: 1501 SRPSFLNSALWDVWDGEEQRPPETPPPAQMPSAGGAQKPEGLETPKGANRKKNLPPKVPI 1560

Query: 1561 TPMPQYSIMETPVLKKELDRFGVRPLPKRQMVLKLKEIFQYTHQTLDSDSEDESQSSQPL 1620
            TPMPQYSIMETPVLKKELDRFGVRPLPKRQMVLKLKEIFQYTHQTLDSDSEDESQSSQPL
Sbjct: 1561 TPMPQYSIMETPVLKKELDRFGVRPLPKRQMVLKLKEIFQYTHQTLDSDSEDESQSSQPL 1620

Query: 1621 LQAPHCQTLASQTYKPSRAGVHAQQEATTGPGAHRPKGPAKTKGPRHQRKHHESITPPSR 1680
            LQAPHCQTLASQTYKPSRAGVHAQQEATTGPGAHRPKGPAKTKGPRHQRKHHESITPPSR
Sbjct: 1621 LQAPHCQTLASQTYKPSRAGVHAQQEATTGPGAHRPKGPAKTKGPRHQRKHHESITPPSR 1680

Query: 1681 SPTKEAPPGLNDDAQIPASQESVATSVDGSDSSLSSQSSSSCEFGAAFESAGEEEGEGEV 1740
            SPTKEAPPGLNDDAQIPASQESVATSVDGSDSSLSSQSSSSCEFGAAFESAGEEEGEGEV
Sbjct: 1681 SPTKEAPPGLNDDAQIPASQESVATSVDGSDSSLSSQSSSSCEFGAAFESAGEEEGEGEV 1740

Query: 1741 SASQAAVQAADTDEALRCYIRSKPALYQKVLLYQPFELRELQAELRQNGLRVSSRRLLDF 1800
            SASQAAVQAADTDEALRCYIRSKPALYQKVLLYQPFELRELQAELRQNGLRVSSRRLLDF
Sbjct: 1741 SASQAAVQAADTDEALRCYIRSKPALYQKVLLYQPFELRELQAELRQNGLRVSSRRLLDF 1800

Query: 1801 LDTHCITFTTAATRREKLQGRRRQPRGKKKVERN 1834
            LDTHCITFTTAATRREKLQGRRRQPRGKKKVERN
Sbjct: 1801 LDTHCITFTTAATRREKLQGRRRQPRGKKKVERN 1834


>gi|132626688 mediator of DNA-damage checkpoint 1 [Homo sapiens]
          Length = 2089

 Score = 55.1 bits (131), Expect = 6e-07
 Identities = 181/943 (19%), Positives = 318/943 (33%), Gaps = 141/943 (14%)

Query: 826  EEEEAETLLKSKDHEEDQENVNEAEMEEIYEFAATQRKLLQEERAAGAGEDADWLEGGSP 885
            E      ++  K H+   E  N+ +++ +   A      L+E        + D  E G+ 
Sbjct: 528  EVPPGSAIIHIKKHQVSVEGTNQTDVKAVGGPAKLLVVSLEEAWPLHGDCETD-AEEGTS 586

Query: 886  VSGQLLAGVQVQKQWDKVEEMEPLEPGRDEAATTWEKMGQCALPPPQGQHSGARGAEAP- 944
            ++  ++A V+  +            P   +A   W       L   +    GA+G     
Sbjct: 587  LTASVVADVRKSQL-----------PAEGDAGAEW---AAAVLKQERAHEVGAQGGPPVA 632

Query: 945  --EQEAP------------EEALGHSSCSSPSRD-----CQAERKE---GSLPHSDDAGD 982
              EQ+ P             + LG S+   P R+        ER++   G+    D+ GD
Sbjct: 633  QVEQDLPISRENLTDLVVDTDTLGEST--QPQREGAQVPTGREREQHVGGTKDSEDNYGD 690

Query: 983  YEQL-------FSSTQGEISEPSQITSEPEEQSGAVRERGLEVSHRL--------APWQA 1027
             E L       F   QG +     +  EP +       + L  SH           PW+ 
Sbjct: 691  SEDLDLQATQCFLENQG-LEAVQSMEDEPTQAFMLTPPQELGPSHCSFQTTGTLDEPWEV 749

Query: 1028 SPPHPCRFLLGPPQGGSPRGSH-HTSGSSLSTPRSRGGTSQVGSPTLLSPAVPSKQKRDR 1086
                P            P  +H    G  LS PR+  G     SP    P     + R  
Sbjct: 750  LATQPFCLRESEDSETQPFDTHLEAYGPCLSPPRAIPGDQHPESPVHTEPMGIQGRGRQT 809

Query: 1087 --SILTLSKEPGHQKGKERRSVLECRNKGVLMFPEKSPSI----DLTQSNPDHS------ 1134
               ++ + KE   + G ER  +     K   + PE+   +    +LT+   D        
Sbjct: 810  VDKVMGIPKETAERVGPERGPLERETEK---LLPERQTDVTGEEELTKGKQDREQKQLLA 866

Query: 1135 -------SSRSQKSSSKLNEEDEVILLLDSDEELELEQTKMKSISSDPLEEKKALEISPR 1187
                   S ++ +S+S   + + + + +++ EE++ +Q + +++ S   E +    ++ R
Sbjct: 867  RDTQRQESDKNGESASPERDRESLKVEIETSEEIQEKQVQKQTLPSKAFEREVERPVANR 926

Query: 1188 SCELFSIIDVDADQEPSQSPPRSEAVLQQEDEGALPENRGSLGRRGAPWLFCDRESSPSE 1247
             C+           E  +  P+   +L+++ +   PE  GS  ++G       + SSP+ 
Sbjct: 927  ECD---------PAELEEKVPK--VILERDTQRGEPEG-GSQDQKG-------QASSPTP 967

Query: 1248 ASTTDTSWLVPAT--PLASRSRDCSSQTQISSLRSGLAVQAVTQHTPRASVGNREGNEVA 1305
                    L   T  P+ S S+     + +S  R    +  +    P A   +R     A
Sbjct: 968  EPGVGAGDLPGPTSAPVPSGSQSGGRGSPVSPRRHQKGL--LNCKMPPAEKASR--IRAA 1023

Query: 1306 QKFSVIRPQTPPPQTPSSCLTPVSPGTSDGRRQGHRSPSRPHPGGHPHSSPLAPHPISGD 1365
            +K S         ++P +CL P  P      ++   S S+ H    P  SPL P      
Sbjct: 1024 EKVS-----RGDQESPDACLPPTVPEAPAPPQKPLNSQSQKHLAPPPLLSPLLP------ 1072

Query: 1366 RAHFSRRFLKHSPPGPSFLNQTPAGEVVEVGDSDDEQEVASHQANRSPPLDSDPPIP-ID 1424
                     K    G     + P     E+     + ++ + +++R  P  +    P   
Sbjct: 1073 --SIKPTVRKTRQDGSQEAPEAPLSS--ELEPFHPKPKIRTRKSSRMTPFPATSAAPEPH 1128

Query: 1425 DCCWHMEPLSPIPIDHWNLERTGPLSTSSPSRRMNEAADSRDCRSPGLLDTTPIRGSCTT 1484
                  +P++P P       RT   S  +P   +  A + +    P      P+    T+
Sbjct: 1129 PSTSTAQPVTPKPTSQATRSRTNRSSVKTPEPVVPTAPELQ----PSTSTDQPVTSEPTS 1184

Query: 1485 QRKLQEKSSGAGSLGNSRPSFLNSALWDVWDGEEQRPPETPPPAQMPSAGGAQKPEGLET 1544
            Q     KS    S   +  + + +AL         RP  + P +Q  +  G +    ++T
Sbjct: 1185 QVTRGRKSR---SSVKTPETVVPTALELQPSTSTDRPVTSEPTSQ--ATRGRKNRSSVKT 1239

Query: 1545 PKGANRKKNLPPKVPITPMPQYSIMETPVLKKELDRFGVRPLPKRQMVLKLKEIFQYTHQ 1604
            P+         P VP  P  Q S      +  E      R    R  V   + +     +
Sbjct: 1240 PE---------PVVPTAPELQPSTSTDQPVTSEPTYQATRGRKNRSSVKTPEPVVPTAPE 1290

Query: 1605 TLDSDSEDESQSSQPLLQAPHCQTLASQTYKPSRAGVHAQQEATTGPGAHRPKGPAKTKG 1664
               S S D   + +P  +    +T  S    P    V    E        +P  P  T  
Sbjct: 1291 LRPSTSTDRPVTPKPTSRTTRSRTNMSSVKTPETV-VPTAPELQISTSTDQPVTPKPTSR 1349

Query: 1665 PRHQRKHHESI-TPPSRSP-TKEAPPGLNDDAQIPASQESVAT 1705
                R +  S+  P S  P   E PP  + +  +     S AT
Sbjct: 1350 TTRSRTNMSSVKNPESTVPIAPELPPSTSTEQPVTPEPTSRAT 1392



 Score = 36.6 bits (83), Expect = 0.23
 Identities = 50/196 (25%), Positives = 77/196 (39%), Gaps = 39/196 (19%)

Query: 30   SSEDQPESLKTGQMMDESDEDFKELCASFFQRVKKHGIKEVSGERKTQKAASNGTQIRSK 89
            S E   ESLK   +  E+ E+ +E      ++V+K  +   + ER+ ++  +N     ++
Sbjct: 882  SPERDRESLK---VEIETSEEIQE------KQVQKQTLPSKAFEREVERPVANRECDPAE 932

Query: 90   LK-RTKQTATKTKTLQGPAEKKPPSGSQAPRTKKQRVTKWQASEPAHSVNGEGGVL---A 145
            L+ +  +   +  T +G    +P  GSQ          K QAS P        G L    
Sbjct: 933  LEEKVPKVILERDTQRG----EPEGGSQDQ--------KGQASSPTPEPGVGAGDLPGPT 980

Query: 146  SAPDP----------PVLRETAQNTQTGNQQEPSPNLSREKTRENVPNSDSQPPPSCLTT 195
            SAP P          PV     Q      +  P+   SR +  E V   D + P +CL  
Sbjct: 981  SAPVPSGSQSGGRGSPVSPRRHQKGLLNCKMPPAEKASRIRAAEKVSRGDQESPDACLPP 1040

Query: 196  AVPS----PSKPRTAQ 207
             VP     P KP  +Q
Sbjct: 1041 TVPEAPAPPQKPLNSQ 1056



 Score = 36.6 bits (83), Expect = 0.23
 Identities = 111/548 (20%), Positives = 188/548 (34%), Gaps = 92/548 (16%)

Query: 1060 RSRGGTSQVGSPTLLSPAVPSKQKRDRSILTLSKEPGHQ--KGKERRSVLECRNKGVLMF 1117
            R R   S   +P  L P  P  +    +   ++ EP  Q  +G+  RS ++     V   
Sbjct: 1393 RGRKNRSSGKTPETLVPTAPKLEPSTSTDQPVTPEPTSQATRGRTNRSSVKTPETVVPTA 1452

Query: 1118 PEKSPSIDLTQ---SNPDHSSSRSQKSSSKLNEEDEVILLLDSDEELELEQTKMKSISSD 1174
            PE  PS    Q     P   ++R +   S +   + V+    +  EL+   +  + ++S+
Sbjct: 1453 PELQPSTSTDQPVTPEPTSQATRGRTDRSSVKTPETVV---PTAPELQASASTDQPVTSE 1509

Query: 1175 PLEEKKALEISPRSCELFSIIDVDADQEPSQSPPRSEAVLQQEDEGALPENRGSLGRRGA 1234
            P         +  S +    + V A  E   S    + V  +      P +R + GR   
Sbjct: 1510 PTSRTTRGRKNRSSVKTPETV-VPAAPELQPSTSTDQPVTPE------PTSRATRGR--- 1559

Query: 1235 PWLFCDRESSPSEASTTDTSWLVPATPLASRSRDCSSQTQISSLRSGLAVQAVTQHTPRA 1294
                    ++ S   T ++  +VP  P          + Q S+ R+ L     T    R 
Sbjct: 1560 --------TNRSSVKTPES--IVPIAP----------ELQPSTSRNQLVTPEPTSRATRC 1599

Query: 1295 SVGNREGNEVAQKFSVIRPQTPPPQTPSSCLTPVSPGTSD--GRRQGHRSPSRPHPGGHP 1352
               NR   +  +    + P  P P   +S   PV+P  +    RR+ +RS  +      P
Sbjct: 1600 RT-NRSSVKTPEP---VVPTAPEPHPTTSTDQPVTPKLTSRATRRKTNRSSVKTPKPVEP 1655

Query: 1353 HSSPLAPHP-----------ISGDRAHFSRRFLKHSPP--------GPSFLNQTPAGEVV 1393
             +S L P               G ++   R     + P         P   +Q  + E +
Sbjct: 1656 AASDLEPFTPTDQSVTPEAIAQGGQSKTLRSSTVRAMPVPTTPEFQSPVTTDQPISPEPI 1715

Query: 1394 EVGDSDDEQEVASHQANRSPPLDSDPPIPIDDCCWHMEPLSPIPID-HWNLERTGPLSTS 1452
                    Q  A +  + + P+D  P      C   +EP S    +  W   R     T+
Sbjct: 1716 TQPSCIKRQRAAGNPGSLAAPIDHKP------CSAPLEPKSQASRNQRWGAVRAAESLTA 1769

Query: 1453 SPSRRMNEAADSRDCRSPGLLDTTPIRGSCTTQRKLQEKSSGAGSLGNSRPSFLNSALWD 1512
             P           +  SP LL+ TPI  S   + +   +S     L          +L  
Sbjct: 1770 IP-----------EPASPQLLE-TPIHASQIQKVEPAGRSRFTPELQPKASQSRKRSLAT 1817

Query: 1513 VWDGEEQRPPETPPPAQM------PSAGGAQKP---EGLETPKGANRKKNLPPKVPITPM 1563
            +     Q+ P+    +Q            A+KP   E + TPK   RK++   + P   +
Sbjct: 1818 MDSPPHQKQPQRGEVSQKTVIIKEEEEDTAEKPGKEEDVVTPKPGKRKRDQAEEEP-NRI 1876

Query: 1564 PQYSIMET 1571
            P  S+  T
Sbjct: 1877 PSRSLRRT 1884



 Score = 35.8 bits (81), Expect = 0.39
 Identities = 84/409 (20%), Positives = 137/409 (33%), Gaps = 52/409 (12%)

Query: 92   RTKQTATKTKTLQGPAEKKPPSGSQAPRTKKQRVTKWQASEPAHSVNGEGGVLASAPDPP 151
            R +QT  K   +  P E     G +  R   +R T+    E    V GE  +     D  
Sbjct: 805  RGRQTVDKVMGI--PKETAERVGPE--RGPLERETEKLLPERQTDVTGEEELTKGKQDRE 860

Query: 152  ----VLRETAQNTQTGNQQEPSPNLSREKTRENVPNSDSQPPPSCLTTAVPSPSKPRTAQ 207
                + R+T +     N +  SP   RE  +  +  S+           +PS +  R   
Sbjct: 861  QKQLLARDTQRQESDKNGESASPERDRESLKVEIETSEEIQEKQVQKQTLPSKAFERE-- 918

Query: 208  LVLQRMQQFKRADPERLRHASEECSLEAAREENVPKDPQEEMMAGNVYGLGPPAPESDAA 267
              ++R    +  DP  L     +  LE   +   P+   ++           P PE    
Sbjct: 919  --VERPVANRECDPAELEEKVPKVILERDTQRGEPEGGSQDQKG----QASSPTPEPGVG 972

Query: 268  VALTLQQEFARVGASAHDDS--------LEEKGLFFCQI-----CQKNLSAMNVTRREQH 314
                     A V + +              +KGL  C++       +  +A  V+R +Q 
Sbjct: 973  AGDLPGPTSAPVPSGSQSGGRGSPVSPRRHQKGLLNCKMPPAEKASRIRAAEKVSRGDQ- 1031

Query: 315  VNRCLDEAEKTLRPSVPQIPECPICGKPFLTLKSRTSHLKQCAVKMEVGPQLLLQAVRLQ 374
                 +  +  L P+VP+ P  P   KP   L S++   K  A    + P L      ++
Sbjct: 1032 -----ESPDACLPPTVPEAPAPP--QKP---LNSQSQ--KHLAPPPLLSPLLPSIKPTVR 1079

Query: 375  TAQPEGSSSPPMFSFSDHSRGLKRRGPTSKKEPRKRRKVDEAPSEDLLVAMALSRSEMEP 434
              + +GS   P    S     L+   P  K   RK  ++   P+         S S  +P
Sbjct: 1080 KTRQDGSQEAPEAPLSSE---LEPFHPKPKIRTRKSSRMTPFPATSAAPEPHPSTSTAQP 1136

Query: 435  GAAVPALRLESAFSERIRPEAENKSRKKKPPVSPPLLLVQDSETTGRQI 483
                P        S+  R      S K   PV P    +Q S +T + +
Sbjct: 1137 VTPKPT-------SQATRSRTNRSSVKTPEPVVPTAPELQPSTSTDQPV 1178



 Score = 35.4 bits (80), Expect = 0.51
 Identities = 37/144 (25%), Positives = 59/144 (40%), Gaps = 18/144 (12%)

Query: 147  APDPPVLRETAQNT-QTGNQQEPSPNLSRE----------KTREN-----VPNSDSQPPP 190
            +P  P ++ T + T Q G+Q+ P   LS E          +TR++      P + + P P
Sbjct: 1068 SPLLPSIKPTVRKTRQDGSQEAPEAPLSSELEPFHPKPKIRTRKSSRMTPFPATSAAPEP 1127

Query: 191  SCLT-TAVPSPSKPRTAQLVLQRMQQFKRADPERLRHASEECSLEAAREENVPKDPQEEM 249
               T TA P   KP T+Q    R  +     PE +   + E     + ++ V  +P  ++
Sbjct: 1128 HPSTSTAQPVTPKP-TSQATRSRTNRSSVKTPEPVVPTAPELQPSTSTDQPVTSEPTSQV 1186

Query: 250  MAGNVYGLGPPAPESDAAVALTLQ 273
              G         PE+    AL LQ
Sbjct: 1187 TRGRKSRSSVKTPETVVPTALELQ 1210



 Score = 33.9 bits (76), Expect = 1.5
 Identities = 27/107 (25%), Positives = 46/107 (42%), Gaps = 5/107 (4%)

Query: 1051 TSGSSLSTPRSRGGTSQVGSPTLLSPAVPSKQKRDRSILTLSKEPGHQ--KGKERRSVLE 1108
            TS  +  T R R   S V +P  + PA P  Q    +   ++ EP  +  +G+  RS ++
Sbjct: 1507 TSEPTSRTTRGRKNRSSVKTPETVVPAAPELQPSTSTDQPVTPEPTSRATRGRTNRSSVK 1566

Query: 1109 CRNKGVLMFPEKSPSI---DLTQSNPDHSSSRSQKSSSKLNEEDEVI 1152
                 V + PE  PS     L    P   ++R + + S +   + V+
Sbjct: 1567 TPESIVPIAPELQPSTSRNQLVTPEPTSRATRCRTNRSSVKTPEPVV 1613


>gi|149158690 HLA-B associated transcript-2 [Homo sapiens]
          Length = 2157

 Score = 54.7 bits (130), Expect = 8e-07
 Identities = 127/562 (22%), Positives = 195/562 (34%), Gaps = 94/562 (16%)

Query: 898  KQWDKVEEMEPLEPGRDEAATTWEKMGQCALPPPQGQHSGARGAEAPEQEAPEEALGHSS 957
            +Q DK      L+  R+ AA   E      LP           A AP    PEEAL   +
Sbjct: 1249 QQQDKPPRFRRLKQERENAARGSEGKPSLTLP-----------ASAP---GPEEALTTVT 1294

Query: 958  CSSPSRDCQAERKEGSLPHSDDAGDYEQLFSST-------QGEISEPSQITSEPEE---- 1006
             +   R   A+  + S  +SD A +  +  S +       +G+   P  +   P+     
Sbjct: 1295 VAPAPRRAAAKSPDLSNQNSDQANEEWETASESSDFTSERRGDKEAPPPVLLTPKAVGTP 1354

Query: 1007 --------------QSGAVRERGLEVSHRLAPWQASPPHPCRFLLGPPQGGSPRGSHHTS 1052
                            G + +R  ++S R   + +  P   R    P  GG    S  +S
Sbjct: 1355 GGGGGGAVPGISAMSRGDLSQRAKDLSKR--SFSSQRPGMERQNRRPGPGGKAGSSGSSS 1412

Query: 1053 GSSLSTPRSRGGTSQVGSPTLLSPAVPSKQKRDRSI-LTLSKEPGHQKGKERRSVLECRN 1111
            G     P  R G  +    +  SP   S+   +R   L L   P       R   +   N
Sbjct: 1413 GGGGGGPGGRTGPGRGDKRSWPSPKNRSRPPEERPPGLPLPPPPPSSSAVFRLDQVIHSN 1472

Query: 1112 -----KGVLMFPEKSPSIDLTQSNPDHSSSRSQKSSSKLN------EEDEVILLLDSDEE 1160
                 + +     +  S+     +P H     Q             E   V   L SD  
Sbjct: 1473 PAGIQQALAQLSSRQGSVTAPGGHPRHKPGLPQAPQGPSPRPPTRYEPQRVNSGLSSDPH 1532

Query: 1161 LELEQTKMKSISSDPLEEK-------KALEISPRSCELFSIIDVDADQEPSQSPPRSEAV 1213
             E     ++ +   P +         K  E  PR  EL         QE S  PP S   
Sbjct: 1533 FEEPGPMVRGVGGTPRDSAGVSPFPPKRRERPPRKPELL--------QEESLPPPHSSGF 1584

Query: 1214 LQQEDEGALP--ENRGSLGRRGAPWLFCDRESSPSEASTTDTS---WLVPATPLASRSRD 1268
            L  + EG  P  E+R +      P ++    ++ S  S   +S   W+ P +P       
Sbjct: 1585 LGSKPEGPGPQAESRDTGTEALTPHIWNRLHTATSRKSYRPSSMEPWMEPLSPFED---- 1640

Query: 1269 CSSQTQISSLRSGLAVQAVTQHT--PRASVGNREGN-EVAQKFSVIRPQTPPPQTPSSCL 1325
              + T++S   SG+ +   +Q +  P +   + +G  + A +    RP    P     C 
Sbjct: 1641 -VAGTEMSQSDSGVDLSGDSQVSSGPCSQRSSPDGGLKGAAEGPPKRPGGSSPLNAVPCE 1699

Query: 1326 TPVSPGTSDGRRQGHRSPSRPHPGGH---PHSSPLAPHPISGDRAHFSRRFLKHSPPGPS 1382
             P  PG+   RR     P  PH G     P   PL P PI  +R   S+R  + + PGP 
Sbjct: 1700 GP--PGSEPPRRP----PPAPHDGDRKELPREQPLPPGPIGTER---SQRTDRGTEPGPI 1750

Query: 1383 FLNQTPAGEVVEVGDSDDEQEV 1404
              +  P G  V+ G SD + ++
Sbjct: 1751 RPSHRP-GPPVQFGTSDKDSDL 1771



 Score = 34.3 bits (77), Expect = 1.1
 Identities = 56/237 (23%), Positives = 82/237 (34%), Gaps = 39/237 (16%)

Query: 1525 PPPAQMPSAGGAQKPEGLETPKGANR-------KKNLPPKVPITPMPQYSIMETPVLKK- 1576
            PP    P   G Q P    TP G +R       + + PP   + P+ + SI++   LK+ 
Sbjct: 256  PPYLPFPPPYGPQGPYRYPTPDGPSRFPRVAGPRGSGPPMRLVEPVGRPSILKEDNLKEF 315

Query: 1577 -ELDRFGVRPLPKRQMVLKLKEIFQYTHQTLDSDSEDE-------SQSSQPLLQAPHC-- 1626
             +LD+            +   E  +++ +    DS++E       SQS+    + P    
Sbjct: 316  DQLDQENDDGWAGAHEEVDYTEKLKFSDEEDGRDSDEEGAEGHRDSQSASGEERPPEADG 375

Query: 1627 ---QTLASQTYKPSRAGVHAQQEATTGPGAHRPKGPAKTKGPRHQRKHHESITPPSRSPT 1683
                +  S+   P  A     +   T PG   PK P               + PP R P 
Sbjct: 376  KKGNSPNSEPPTPKTAWAETSRPPETEPGPPAPKPP---------------LPPPHRGPA 420

Query: 1684 KE-APPGLNDDAQIPASQESVATSVDGSDSSLSSQSSSSCEFGAAFESAGEEEGEGE 1739
                PPG   D   P  +       D +      QSSS  E   A E A     E E
Sbjct: 421  GNWGPPGDYPDRGGPPCKPPAPEDEDEAWRQRRKQSSS--EISLAVERARRRREEEE 475



 Score = 32.0 bits (71), Expect = 5.7
 Identities = 65/266 (24%), Positives = 95/266 (35%), Gaps = 49/266 (18%)

Query: 401  PTSKKEPRKRRKVDEAPSEDLLVAMALSRSEMEPGAAVPALRLESAFSERIRPEAENKSR 460
            P     P+K       PS++ L      + ++ PG   P  R  S     +  E   + R
Sbjct: 1188 PAKSLAPKKPPTGPLPPSKEPL------KEKLIPGPLSPVARGGSNGGSNVGMEDGERPR 1241

Query: 461  KKK-----PPVSPPLL--LVQDSETTGRQIEDRVALLLSEEVELSSTPPLPASRILKEGW 513
            +++         PP    L Q+ E   R  E + +L L            PAS    E  
Sbjct: 1242 RRRHGRAQQQDKPPRFRRLKQERENAARGSEGKPSLTL------------PASAPGPEEA 1289

Query: 514  ERAGQCPPPPERKQSFLWEGSALTGAWAMEDFYTARLVPPLVPQRPAQGLMQEPVPPLVP 573
                   P P R  +   + S      A E++ TA        +R  +G  + P P L+ 
Sbjct: 1290 LTTVTVAPAPRRAAAKSPDLSNQNSDQANEEWETASESSDFTSER--RGDKEAPPPVLLT 1347

Query: 574  PEHSELSERRSPALHGTPTAGCGSRGPSPSASQREHQALQDLVDLAREGLSA-------- 625
            P+             GTP  G G   P  SA  R   + Q   DL++   S+        
Sbjct: 1348 PKAV-----------GTPGGGGGGAVPGISAMSRGDLS-QRAKDLSKRSFSSQRPGMERQ 1395

Query: 626  SPWPGSGGLAGSEGTA--GLDVVPGG 649
            +  PG GG AGS G++  G    PGG
Sbjct: 1396 NRRPGPGGKAGSSGSSSGGGGGGPGG 1421


>gi|115430108 rho-related BTB domain containing 3 [Homo sapiens]
          Length = 611

 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 42/127 (33%), Positives = 62/127 (48%), Gaps = 10/127 (7%)

Query: 685 VNNPHLSDVQFQTDSGEVLYAHKFVLYARCPLLIQYVNNEGFSAVEDGVLTQRVLLGDVS 744
           +N P L+DV F+   G  + AH+ +L ARC ++    N     A    VL   + +  VS
Sbjct: 414 LNKPMLADVVFEIQ-GTTVPAHRAILVARCEVMAAMFNGNYMEA--KSVL---IPVYGVS 467

Query: 745 TEAARTFLHYLYTADTGLPPGLSSELSSL--AHRFGVSELVHLCEQVPIATDSEGKPWEE 802
            E   +FL YLYT D+  P G+   +  L  A  + VS L H+CE + I T  +  P  E
Sbjct: 468 KETFLSFLEYLYT-DSCCPAGIFQAMCLLICAEMYQVSRLQHICE-LFIITQLQSMPSRE 525

Query: 803 KEAENCE 809
             + N +
Sbjct: 526 LASMNLD 532


>gi|150418009 transforming, acidic coiled-coil containing protein 2
            isoform a [Homo sapiens]
          Length = 2948

 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 84/373 (22%), Positives = 138/373 (36%), Gaps = 51/373 (13%)

Query: 1350 GHPHSSPLAPHPISGDRAHFSRRFLKHSPPGPSFLNQ-------TPAGEVVEVGDSDDEQ 1402
            G+P +  LAP   S   +  S    +   P P  L +       T    V E     DE+
Sbjct: 2101 GNPEAVALAPDAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKETQQEPDEE 2160

Query: 1403 EV-------ASHQANRSPPLDSDPPIPIDDCCWH--MEPLSPIPIDHWNLERTGPLSTSS 1453
             +       AS     S   +   P  +++      + P +  P+D  + E   P   S 
Sbjct: 2161 SLVPSGENLASETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGVVP-PASG 2219

Query: 1454 PSRRMNEAADSRDCRSPGLLDTTPIRGSCTTQRKLQEKSSGAGSLGNSRPSFLNSALWDV 1513
              R  N     R       L T P  G  T      ++ S A  L + R  F  S     
Sbjct: 2220 GGRVQNSPPVGRKTLP---LTTAPEAGEVTPSDSGGQEDSPAKGL-SVRLEFDYSEDKSS 2275

Query: 1514 WDGEEQRPPET-----PPPAQMPSAGGAQKPEGLETPKGANRKKNLPPKVPITPMPQYSI 1568
            WD +++ PP T      P A+MP     ++P+  +TP+  +     PP+ P  P      
Sbjct: 2276 WDNQQENPPPTKKIGKKPVAKMP----LRRPKMKKTPEKLDNTPASPPRSPAEP------ 2325

Query: 1569 METPVLKK----ELDRFGVRPLPKRQMVLKLKEIFQYTHQTLDSDSEDESQSSQPLLQAP 1624
             + P+ K     ++D++            K++E  +   Q+ + D +   +S  P   + 
Sbjct: 2326 NDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYNFDPDTCDESVDPFKTS- 2384

Query: 1625 HCQTLASQTYKPSRAGVHA---QQEATTGPGAHRP----KGPAKTKGPRHQR--KHHESI 1675
              +T +S +  P+   + A   +     G G ++P    K P KT   R ++  K     
Sbjct: 2385 -SKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPAKKKKTPLKTDTFRVKKSPKRSPLS 2443

Query: 1676 TPPSRSPTKEAPP 1688
             PPS+ PT  A P
Sbjct: 2444 DPPSQDPTPAATP 2456



 Score = 35.8 bits (81), Expect = 0.39
 Identities = 99/496 (19%), Positives = 163/496 (32%), Gaps = 102/496 (20%)

Query: 1264 SRSRDCSSQTQISSLRSGLAVQAVTQHTPRASVGNREGNEVAQKFSVIRPQTPPPQTPSS 1323
            S+ ++ +     +  R G+A   VT   P A+    E + V +K S ++P  P PQ P+ 
Sbjct: 225  SQEKEAAGGFPPAESRQGVASVQVTPEAPAAAQQGTESSAVLEK-SPLKPMAPIPQDPA- 282

Query: 1324 CLTPVSPGTSDGRRQGHRSPSRPHPGGHPHSSPLAPHPISGDRAHFSRRFLKHSPPGPSF 1383
                  P  SD  R    +P               P  ++ D        L  S  G + 
Sbjct: 283  ------PRASDRERGQGEAP---------------PQYLTDDLEFLRACHLPRSNSGAA- 320

Query: 1384 LNQTPAGEVVEVGDSDDEQEVASHQANRSPPLDSDPPIPIDDCCWHMEPLSPIPIDHWNL 1443
                P  EV        +Q V ++  +   P                          W L
Sbjct: 321  ----PEAEVNAASQESCQQPVGAYLPHAELP--------------------------WGL 350

Query: 1444 ERTGPLSTSSPSRRMNEAADSRDCRS---PGLLDTTPIRGSCTTQRKLQEKSSGAGSLGN 1500
                 +  +  S +  EA D+ D +     G+  T P +  C       E     G   +
Sbjct: 351  PSPALVPEAGGSGK--EALDTIDVQGHPQTGMRGTKPNQVVCVAAGGQPE----GGLPVS 404

Query: 1501 SRPSFLNSALWDVWDGEEQRPPETPPPAQMPSAGGAQKPEGLETPKGANRKKNLPPKVPI 1560
              PS L                E  P + + S   AQ P  +E P  ++R+      +P+
Sbjct: 405  PEPSLLTPT------------EEAHPASSLASFPAAQIPIAVEEPGSSSRESVSKAGMPV 452

Query: 1561 TPMPQYSIMETPV--LKKELDRFGVR-PLPKRQMVLKLKEIFQYTHQTLDSDSEDESQSS 1617
            +      +++  +  L++++   G +   P+           Q   + L+++   E Q  
Sbjct: 453  SADAAKEVVDAGLVGLERQVSDLGSKGEHPEGDPGEVPAPSPQERGEHLNTEQSHEVQPG 512

Query: 1618 QPLLQAPHCQTLASQTYKPSRAGVHAQQEATTGPGAHRPKGPAKTKGPRHQRKHHESITP 1677
             P    P  Q+   Q   P      A  E+  GP            GP    K HE  T 
Sbjct: 513  VPPPPLPKEQSHEVQPGAPPPPLPKAPSESARGP-----------PGPTDGAKVHEDSTS 561

Query: 1678 PSRSPTKEAPPGLNDDAQIPASQESVATSVDGSD-SSLSSQSSSSCEFGAAFESAGEEE- 1735
            P+ +      PG       P  +E      DG D  +L  + S       AF S  + E 
Sbjct: 562  PAVAKEGSRSPG-----DSPGGKEEAPEPPDGGDPGNLQGEDSQ------AFSSKRDPEV 610

Query: 1736 GEGEVSASQAAVQAAD 1751
            G+ E+S   +  ++ D
Sbjct: 611  GKDELSKPSSDAESRD 626



 Score = 32.0 bits (71), Expect = 5.7
 Identities = 35/129 (27%), Positives = 40/129 (31%), Gaps = 18/129 (13%)

Query: 1300 EGNEVAQKFSVIRPQTPPPQTPSSCLTPVSPGTSDGRRQGHRSPSRPHPGGHPHSSPLAP 1359
            EG       S  RPQ    Q       P   G     +    SP  P     P    LAP
Sbjct: 1759 EGTAALHGDSPARPQQAKEQPGPERPIPAGDG-----KVCVSSPPEPDETHDPKLQHLAP 1813

Query: 1360 HPISGDRAHFSRRFLKHSP-PGPSFLNQTPAGEVVEVGDSDDEQEVASHQANRSPPLDSD 1418
              +  DR          SP PGPS L   P  +   V D     E    +   S P+  D
Sbjct: 1814 EELHTDR---------ESPRPGPSMLPSVPKKDAPRVMDKVTSDETRGAEGTESSPVADD 1864

Query: 1419 ---PPIPID 1424
               P  P D
Sbjct: 1865 IIQPAAPAD 1873



 Score = 31.2 bits (69), Expect = 9.7
 Identities = 30/119 (25%), Positives = 48/119 (40%), Gaps = 18/119 (15%)

Query: 99  KTKTLQGPAEKKPPSGSQAPRTKKQRVTKWQASEPAHSVN--GEGGVLASAP-----DP- 150
           +T + Q P   +PP  SQ  + K+Q          A S+   G GG   ++      DP 
Sbjct: 12  RTLSAQTPRSAQPPGNSQNIKRKQQDTPGSPDHRDASSIGSVGLGGFCTASESSASLDPC 71

Query: 151 ---PVLRETAQNTQTGNQQE------PSPNLSREKTRENVPNSDSQPPPSCLTTAVPSP 200
              P + E  ++ Q     E      P P+  RE    ++P ++  PP  CL +   +P
Sbjct: 72  LVSPEVTEPRKDPQGARGPEGSLLPSPPPSQEREHPSSSMPFAEC-PPEGCLASPAAAP 129


>gi|45827755 transforming, acidic coiled-coil containing protein 2
            isoform b [Homo sapiens]
          Length = 1094

 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 84/373 (22%), Positives = 138/373 (36%), Gaps = 51/373 (13%)

Query: 1350 GHPHSSPLAPHPISGDRAHFSRRFLKHSPPGPSFLNQ-------TPAGEVVEVGDSDDEQ 1402
            G+P +  LAP   S   +  S    +   P P  L +       T    V E     DE+
Sbjct: 247  GNPEAVALAPDAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKETQQEPDEE 306

Query: 1403 EV-------ASHQANRSPPLDSDPPIPIDDCCWH--MEPLSPIPIDHWNLERTGPLSTSS 1453
             +       AS     S   +   P  +++      + P +  P+D  + E   P   S 
Sbjct: 307  SLVPSGENLASETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGVVP-PASG 365

Query: 1454 PSRRMNEAADSRDCRSPGLLDTTPIRGSCTTQRKLQEKSSGAGSLGNSRPSFLNSALWDV 1513
              R  N     R       L T P  G  T      ++ S A  L + R  F  S     
Sbjct: 366  GGRVQNSPPVGRKTLP---LTTAPEAGEVTPSDSGGQEDSPAKGL-SVRLEFDYSEDKSS 421

Query: 1514 WDGEEQRPPET-----PPPAQMPSAGGAQKPEGLETPKGANRKKNLPPKVPITPMPQYSI 1568
            WD +++ PP T      P A+MP     ++P+  +TP+  +     PP+ P  P      
Sbjct: 422  WDNQQENPPPTKKIGKKPVAKMP----LRRPKMKKTPEKLDNTPASPPRSPAEP------ 471

Query: 1569 METPVLKK----ELDRFGVRPLPKRQMVLKLKEIFQYTHQTLDSDSEDESQSSQPLLQAP 1624
             + P+ K     ++D++            K++E  +   Q+ + D +   +S  P   + 
Sbjct: 472  NDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYNFDPDTCDESVDPFKTS- 530

Query: 1625 HCQTLASQTYKPSRAGVHA---QQEATTGPGAHRP----KGPAKTKGPRHQR--KHHESI 1675
              +T +S +  P+   + A   +     G G ++P    K P KT   R ++  K     
Sbjct: 531  -SKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPAKKKKTPLKTDTFRVKKSPKRSPLS 589

Query: 1676 TPPSRSPTKEAPP 1688
             PPS+ PT  A P
Sbjct: 590  DPPSQDPTPAATP 602


>gi|45827753 transforming, acidic coiled-coil containing protein 2
            isoform c [Homo sapiens]
          Length = 996

 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 84/373 (22%), Positives = 138/373 (36%), Gaps = 51/373 (13%)

Query: 1350 GHPHSSPLAPHPISGDRAHFSRRFLKHSPPGPSFLNQ-------TPAGEVVEVGDSDDEQ 1402
            G+P +  LAP   S   +  S    +   P P  L +       T    V E     DE+
Sbjct: 179  GNPEAVALAPDAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKETQQEPDEE 238

Query: 1403 EV-------ASHQANRSPPLDSDPPIPIDDCCWH--MEPLSPIPIDHWNLERTGPLSTSS 1453
             +       AS     S   +   P  +++      + P +  P+D  + E   P   S 
Sbjct: 239  SLVPSGENLASETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGVVP-PASG 297

Query: 1454 PSRRMNEAADSRDCRSPGLLDTTPIRGSCTTQRKLQEKSSGAGSLGNSRPSFLNSALWDV 1513
              R  N     R       L T P  G  T      ++ S A  L + R  F  S     
Sbjct: 298  GGRVQNSPPVGRKTLP---LTTAPEAGEVTPSDSGGQEDSPAKGL-SVRLEFDYSEDKSS 353

Query: 1514 WDGEEQRPPET-----PPPAQMPSAGGAQKPEGLETPKGANRKKNLPPKVPITPMPQYSI 1568
            WD +++ PP T      P A+MP     ++P+  +TP+  +     PP+ P  P      
Sbjct: 354  WDNQQENPPPTKKIGKKPVAKMP----LRRPKMKKTPEKLDNTPASPPRSPAEP------ 403

Query: 1569 METPVLKK----ELDRFGVRPLPKRQMVLKLKEIFQYTHQTLDSDSEDESQSSQPLLQAP 1624
             + P+ K     ++D++            K++E  +   Q+ + D +   +S  P   + 
Sbjct: 404  NDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYNFDPDTCDESVDPFKTS- 462

Query: 1625 HCQTLASQTYKPSRAGVHA---QQEATTGPGAHRP----KGPAKTKGPRHQR--KHHESI 1675
              +T +S +  P+   + A   +     G G ++P    K P KT   R ++  K     
Sbjct: 463  -SKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPAKKKKTPLKTDTFRVKKSPKRSPLS 521

Query: 1676 TPPSRSPTKEAPP 1688
             PPS+ PT  A P
Sbjct: 522  DPPSQDPTPAATP 534


>gi|11119414 transforming, acidic coiled-coil containing protein 2
            isoform d [Homo sapiens]
          Length = 1026

 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 84/373 (22%), Positives = 138/373 (36%), Gaps = 51/373 (13%)

Query: 1350 GHPHSSPLAPHPISGDRAHFSRRFLKHSPPGPSFLNQ-------TPAGEVVEVGDSDDEQ 1402
            G+P +  LAP   S   +  S    +   P P  L +       T    V E     DE+
Sbjct: 179  GNPEAVALAPDAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKETQQEPDEE 238

Query: 1403 EV-------ASHQANRSPPLDSDPPIPIDDCCWH--MEPLSPIPIDHWNLERTGPLSTSS 1453
             +       AS     S   +   P  +++      + P +  P+D  + E   P   S 
Sbjct: 239  SLVPSGENLASETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGVVP-PASG 297

Query: 1454 PSRRMNEAADSRDCRSPGLLDTTPIRGSCTTQRKLQEKSSGAGSLGNSRPSFLNSALWDV 1513
              R  N     R       L T P  G  T      ++ S A  L + R  F  S     
Sbjct: 298  GGRVQNSPPVGRKTLP---LTTAPEAGEVTPSDSGGQEDSPAKGL-SVRLEFDYSEDKSS 353

Query: 1514 WDGEEQRPPET-----PPPAQMPSAGGAQKPEGLETPKGANRKKNLPPKVPITPMPQYSI 1568
            WD +++ PP T      P A+MP     ++P+  +TP+  +     PP+ P  P      
Sbjct: 354  WDNQQENPPPTKKIGKKPVAKMP----LRRPKMKKTPEKLDNTPASPPRSPAEP------ 403

Query: 1569 METPVLKK----ELDRFGVRPLPKRQMVLKLKEIFQYTHQTLDSDSEDESQSSQPLLQAP 1624
             + P+ K     ++D++            K++E  +   Q+ + D +   +S  P   + 
Sbjct: 404  NDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYNFDPDTCDESVDPFKTS- 462

Query: 1625 HCQTLASQTYKPSRAGVHA---QQEATTGPGAHRP----KGPAKTKGPRHQR--KHHESI 1675
              +T +S +  P+   + A   +     G G ++P    K P KT   R ++  K     
Sbjct: 463  -SKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPAKKKKTPLKTDTFRVKKSPKRSPLS 521

Query: 1676 TPPSRSPTKEAPP 1688
             PPS+ PT  A P
Sbjct: 522  DPPSQDPTPAATP 534


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 48.9 bits (115), Expect = 4e-05
 Identities = 78/408 (19%), Positives = 142/408 (34%), Gaps = 57/408 (13%)

Query: 826  EEEEAETLLKSKDHEEDQ--ENVNEAEMEEIYEFAATQRKLLQEERAAGAGEDADWLEGG 883
            E+ E ET++  +  EE Q  E V E E +E  E    + +  +EE A G  E+       
Sbjct: 448  EKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETK----- 502

Query: 884  SPVSGQLLAGVQVQKQWDKVEEMEPLEPGRDEAATTWEKMGQCALPPPQGQHSGARGAEA 943
            SP + +  +            E E   P ++EA +  E                A+  E 
Sbjct: 503  SPPAEEAAS-----------PEKEAKSPVKEEAKSPAE----------------AKSPEK 535

Query: 944  PEQEAPEEALGHSSCSSPSRDCQAERKEGSLPHSDDA------GDYEQLFSSTQGEISEP 997
             E ++P E        SP+++      E   P  ++A         E+  S  + E   P
Sbjct: 536  EEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSP 595

Query: 998  SQITSEPEEQSGAVRERGLEVSHRLAPWQASPPHPCRFLLGPPQGGSPRGSHHTSGSSLS 1057
            ++  S PE+    V+E     +   +P +     P   +  P +  SP      S     
Sbjct: 596  AEAKS-PEKAKSPVKEEAKSPAEAKSPVKEEAKSPAE-VKSPEKAKSPTKEEAKSPEKAK 653

Query: 1058 TPRSRGGTSQVGSPTLLSPAVPSKQKRDRSILTLSKEPGHQKGKERRSVLECRNKGVLMF 1117
            +P      S   + + +     S +K    +   +K P   K   +    +   K     
Sbjct: 654  SPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEA-KSPEKAKSPV 712

Query: 1118 PEKSPSIDLTQSNPDHSSSRSQKSSSKLNEEDEVILLLDSDEELELEQTKMKSISSDPLE 1177
             E++ S +  +S     +   +K+ S + EE +      S E+ +    K     +   E
Sbjct: 713  KEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKE 772

Query: 1178 EKKALEISPRSCELFSIIDVDADQEPSQSPPRSEAVLQQEDEGALPEN 1225
            E ++                D   E ++SP + E    ++ +  L E+
Sbjct: 773  EARS--------------PADKFPEKAKSPVKEEVKSPEKAKSPLKED 806



 Score = 48.9 bits (115), Expect = 4e-05
 Identities = 93/490 (18%), Positives = 181/490 (36%), Gaps = 45/490 (9%)

Query: 787  EQVPIATDSEGKPWEEKEAENCESRAENFQELLRSMWADEEEEAETLLKSKDHEEDQENV 846
            E+   A + EGK  E  E E  E   E  +       A  E+EA++ +K     E+ ++ 
Sbjct: 473  EEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVK-----EEAKSP 527

Query: 847  NEAEMEEIYEFAATQRKLLQEERAAGAGEDADWLEGGSPVSGQLLAGVQVQKQWDKVEEM 906
             EA+  E  E A +  ++   E+A    ++    E  SP   +     + +   +     
Sbjct: 528  AEAKSPE-KEEAKSPAEVKSPEKAKSPAKE----EAKSPPEAKSPEKEEAKSPAEVKSPE 582

Query: 907  EPLEPGRDEAATTWE-KMGQCALPPPQGQHSGARGAEAP---EQEAPEEALGHSSCSSPS 962
            +   P ++EA +  E K  + A  P + +      A++P   E ++P E        SP+
Sbjct: 583  KAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPT 642

Query: 963  RDCQAERKEGSLPHSDDAGDYEQLFSSTQGEISEPSQITS-------EPEEQSGAVRERG 1015
            ++     ++   P  ++A   E+  S  + E   P +  S        PE+    V+E  
Sbjct: 643  KEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEA 702

Query: 1016 LEVSHRLAP--WQASPPHPCRFLL-----GPPQGGSPRGSHHTSGSSLSTPRSRGGTSQV 1068
                   +P   +A  P   +  +      P +  SP      S     +P  +  T  V
Sbjct: 703  KSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSP-EKAKTLDV 761

Query: 1069 GSPTLLSPAVPSKQKRDRSILTLSKEPGHQKGKERRSVLECRNKGVLMFPEKSPSIDLTQ 1128
             SP   +PA    +         +K P  ++ K        + K  L    K+P  ++ +
Sbjct: 762  KSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPE-----KAKSPLKEDAKAPEKEIPK 816

Query: 1129 SNPDHSSSRSQ--------KSSSKLNEEDEVILLLDSDE--ELELEQTKMKSISSDPLEE 1178
                 S  + +        K   K  EE++      ++E  + + E+   K      +EE
Sbjct: 817  KEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEE 876

Query: 1179 KKALEI-SPRSCELFSIIDVDADQEPSQSPPRSEAVLQQEDEGALPENRGSLGRRGAPWL 1237
            KK   +  P+  ++ +  +   D++   +P +      +  E A P+ +  + ++     
Sbjct: 877  KKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDA 936

Query: 1238 FCDRESSPSE 1247
                 S P+E
Sbjct: 937  KAKEPSKPAE 946



 Score = 32.7 bits (73), Expect = 3.3
 Identities = 34/168 (20%), Positives = 64/168 (38%), Gaps = 12/168 (7%)

Query: 1607 DSDSEDESQSSQPLLQAPHCQTLAS---QTYKPSRAGVHAQQEATTGPGAHRPKGPAKTK 1663
            +   E+E++  +   ++P  +  AS   +   P +    +  EA + P     K PA+ K
Sbjct: 487  EGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKS-PEKEEAKSPAEVK 545

Query: 1664 GPRHQR---KHHESITPPSRSPTKE-----APPGLNDDAQIPASQESVATSVDGSDSSLS 1715
             P   +   K      P ++SP KE     A     + A+ PA +E+ + +   S     
Sbjct: 546  SPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAK 605

Query: 1716 SQSSSSCEFGAAFESAGEEEGEGEVSASQAAVQAADTDEALRCYIRSK 1763
            S      +  A  +S  +EE +            + T E  +   ++K
Sbjct: 606  SPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAK 653


>gi|40807477 retinoic acid induced 1 [Homo sapiens]
          Length = 1906

 Score = 48.9 bits (115), Expect = 4e-05
 Identities = 139/606 (22%), Positives = 204/606 (33%), Gaps = 96/606 (15%)

Query: 1190 ELFSIIDVDADQEPSQSPPRSEAVLQQEDEGALPENRGSLGR-----RGAPWLFCDRESS 1244
            E  + +    +  P +         +QE+ G + E  G L +     +   WL    E S
Sbjct: 786  EASACLGFQEEDPPGEKVASLPGDFKQEEVGGVKEEAGGLLQCPEVAKADRWL----EDS 841

Query: 1245 PSEASTTDTSWLVPATPLASRSRDCSSQTQISSLRSGLAVQAVTQHTPRASVGNREGNEV 1304
                ST D   L P  P  SR  D  ++ + SSL   L        +P    G ++    
Sbjct: 842  RHCCSTADFGDL-PLLPPTSRKEDLEAEEEYSSLCELLG-------SPEQRPGMQDPLS- 892

Query: 1305 AQKFSVIRPQTPPPQTPSSCLTPVSPGTSDGRRQGHRSPSRPHPGGHPHSSPLAPHPISG 1364
                         P+ P  C         D +  G  SP   H  G    S +   P  G
Sbjct: 893  -------------PKAPLICTKEEVEEVLDSKA-GWGSPC--HLSGE---SVILLGPTVG 933

Query: 1365 DRAHFSRRF---LKHSPPGPSFLNQTPAGEVVEVGDSDDEQEVASHQANRSPPLDSDPPI 1421
              +     F   L H  PG     + P GE    GDS       + + N+  P   + PI
Sbjct: 934  TESKVQSWFESSLSHMKPG----EEGPDGERAP-GDSTTSDASLAQKPNK--PAVPEAPI 986

Query: 1422 PIDDCCWHMEPLSPIPIDHWNLERTGPLSTSSPSRRMNEAADSRDCRSPGLLDTTPIRGS 1481
               +         P+P       R   L +    R + EA DS  CR+P L     +  S
Sbjct: 987  AKKE---------PVP-------RGKSLRSRRVHRGLPEAEDS-PCRAPVLPKDLLLPES 1029

Query: 1482 CTTQRKLQEKSSGAGSLGNSR--PSFLNSALWDVWDGEEQRPPE-TPPPAQMPSAGGAQ- 1537
            CT   + Q + +GA   G S   P     +L  + +     PP  T  PA     GG Q 
Sbjct: 1030 CTGPPQGQMEGAGAPGRGASEGLPRMCTRSLTALSEPRTPGPPGLTTTPAPPDKLGGKQR 1089

Query: 1538 ------KPEGLETPKGANRKKNLPPKVPITPMPQYSIMETPVLKKELDRFGVRPLPKRQM 1591
                  K  G  +PK A+   N P  +P+         +T    KE D        +R M
Sbjct: 1090 AAFKSGKRVGKPSPKAASSPSN-PAALPVASDSSPMGSKT----KETDSPSTPGKDQRSM 1144

Query: 1592 VL----KLKEIFQYTHQTLDSDSEDESQSSQPLLQAPHCQTLASQTYKPSRAGVHAQQEA 1647
            +L    K +EIF    +          ++++ LL   H       +  P + G  +Q+  
Sbjct: 1145 ILRSRTKTQEIFHSKRRRPSEGRLPNCRATKKLLDNSHLPATFKVSSSPQKEGRVSQRAR 1204

Query: 1648 TTGPGAHRPKGPAKTKGPRHQRKHHESITPPSRSPTKEAPPGLNDDAQIPASQESVATSV 1707
               PGA    G   +  P H  K   +   P   PTK+    L        S  S   S 
Sbjct: 1205 VPKPGA----GSKLSDRPLHALKRKSAFMAP--VPTKKRNLVLRS-----RSSSSSNASG 1253

Query: 1708 DGSDSSLSSQSSSSCEFG--AAFESAGEEEGEGEVSASQAAVQAADTDEALRCYIRSKPA 1765
            +G D        S   F   ++ + A   +G GE +      +  D    L      + A
Sbjct: 1254 NGGDGKEERPEGSPTLFKRMSSPKKAKPTKGNGEPATKLPPPETPDACLKLASRAAFQGA 1313

Query: 1766 LYQKVL 1771
            +  KVL
Sbjct: 1314 MKTKVL 1319



 Score = 34.7 bits (78), Expect = 0.88
 Identities = 56/224 (25%), Positives = 87/224 (38%), Gaps = 34/224 (15%)

Query: 25   GIDPRSSEDQPESLKTGQMMDESDEDFKELCASFFQRVKKHGI---KEVSGER--KTQKA 79
            G  P   E+   ++ TGQ +  S  D   LC +   R  K  +   K++S     KT+  
Sbjct: 1372 GGSPVGVEEGLVNVGTGQKLPTSGAD--PLCRNPTNRSLKGKLMNSKKLSSTDCFKTEAF 1429

Query: 80   AS------NGTQIRSKLKRTKQTATKTKTLQGPAEKKPPSGSQAPRTKKQRVTKWQASEP 133
             S       GT +  K +  K  A      +GP EK+P  G     T + R +  Q +  
Sbjct: 1430 TSPEALQPGGTALAPKKRSRKGRAGAHGLSKGPLEKRPYLGPALLLTPRDRASGTQGASE 1489

Query: 134  AHSVNG-------EGGVLASAPD-PPVLRETAQNTQTGNQQEPSPNLSREKTRENVPNSD 185
             +S  G       E G+ +  P+  P   +T    Q G+    S +  +  TR    N+ 
Sbjct: 1490 DNSGGGGKKPKMEELGLASQPPEGRPCQPQTRAQKQPGHTNYSSYSKRKRLTRGRAKNTT 1549

Query: 186  SQPPPSCLTTAVPSPSKPRTAQLVLQRMQQFKRADPE-RLRHAS 228
            S            SP K R  +   Q++     A+PE RL++ S
Sbjct: 1550 S------------SPCKGRAKRRRQQQVLPLDPAEPEIRLKYIS 1581



 Score = 34.3 bits (77), Expect = 1.1
 Identities = 95/442 (21%), Positives = 151/442 (34%), Gaps = 80/442 (18%)

Query: 940  GAEAPEQEAPEEALGHSSCSSPSRDCQAERKEGSLPHSDDAGDYEQLFSSTQGEISEPSQ 999
            G E+  Q   E +L H        D   ER  G    SD +   +      +  + E   
Sbjct: 933  GTESKVQSWFESSLSHMKPGEEGPD--GERAPGDSTTSDASLAQKP----NKPAVPEAPI 986

Query: 1000 ITSEPEEQSGAVRERGLEVSHRLAPWQASPPHPCR-------FLL-----GPPQGGSPRG 1047
               EP  +  ++R R +   HR  P   +   PCR        LL     GPPQG     
Sbjct: 987  AKKEPVPRGKSLRSRRV---HRGLP--EAEDSPCRAPVLPKDLLLPESCTGPPQGQMEGA 1041

Query: 1048 SHHTSGSSLSTPR--SRGGTSQVGSPTLLSPAVPSKQKRDRSILTLSKEPGHQKGKERRS 1105
                 G+S   PR  +R  T+      L  P  P        + T    P    GK+R +
Sbjct: 1042 GAPGRGASEGLPRMCTRSLTA------LSEPRTPGPP----GLTTTPAPPDKLGGKQRAA 1091

Query: 1106 VLECRNKG-----VLMFPEKSPSIDL-TQSNPDHSSSRSQKSSSKLNEEDEVILLLDSDE 1159
                +  G         P    ++ + + S+P  S ++   S S   ++   ++L    +
Sbjct: 1092 FKSGKRVGKPSPKAASSPSNPAALPVASDSSPMGSKTKETDSPSTPGKDQRSMILRSRTK 1151

Query: 1160 ELELEQTKMKSISSDPLEEKKALEISPRSCELFSIIDVDADQEPSQSPPRSEAVLQQEDE 1219
              E+  +K +  S   L   +A +      +L     + A  + S SP +   V Q    
Sbjct: 1152 TQEIFHSKRRRPSEGRLPNCRATK------KLLDNSHLPATFKVSSSPQKEGRVSQ---- 1201

Query: 1220 GALPENRGSLGRRGAPWLFCDRESSPSEASTTDTSWLVPATPLASRSRDCSSQTQISSLR 1279
                  R  + + GA     DR   P  A    ++++ P  P   R+    S++  SS  
Sbjct: 1202 ------RARVPKPGAGSKLSDR---PLHALKRKSAFMAPV-PTKKRNLVLRSRSSSSSNA 1251

Query: 1280 SGLAVQAVTQH------------TPRASVGNREGNEVAQKFSVIRPQTPPPQTPSSCLTP 1327
            SG       +             +P+ +   +   E A K        PPP+TP +CL  
Sbjct: 1252 SGNGGDGKEERPEGSPTLFKRMSSPKKAKPTKGNGEPATKL-------PPPETPDACLKL 1304

Query: 1328 VSPGTSDGRRQGHRSPSRPHPG 1349
             S     G  +    P R   G
Sbjct: 1305 ASRAAFQGAMKTKVLPPRKGRG 1326


>gi|19924099 synapsin I isoform Ia [Homo sapiens]
          Length = 705

 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 65/260 (25%), Positives = 79/260 (30%), Gaps = 49/260 (18%)

Query: 1314 QTPPPQTPSSCLTPVSPGTSDGRRQGHRSPSRPHPGGHPHSSPLAPHPISGDRAHFSRRF 1373
            Q PPPQ       P  PG    +RQG     RP P G  H S L P   S          
Sbjct: 459  QRPPPQGG-----PPQPGPGP-QRQGPPLQQRPPPQGQQHLSGLGPPAGSP--------- 503

Query: 1374 LKHSPPGPSFLNQTPAGEVVEVGDSDDEQE-----------VASHQANRSPPLDSDPPIP 1422
            L    P P+   Q PA +          Q             A   A+ SP   + PP  
Sbjct: 504  LPQRLPSPTSAPQQPASQAAPPTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGPP-- 561

Query: 1423 IDDCCWHMEPLSPIPIDHWNLERTGPLSTSSPSRRMNEAADSRDCRSPGLLDTTPIRGSC 1482
                        P P         G      P +    A  +R     G     P  G  
Sbjct: 562  --QATRQTSVSGPAPPKASGAPPGGQQRQGPPQKPPGPAGPTRQASQAG---PVPRTGPP 616

Query: 1483 TTQRKLQEKSSGAGSLGNSRPSFLNSALWDVWDGEEQRPPETPPPAQMPSAGGAQKPEGL 1542
            TTQ   Q + SG G  G  +P               Q+P +  PP    +AGG   P+ L
Sbjct: 617  TTQ---QPRPSGPGPAGRPKPQL------------AQKPSQDVPPPATAAAGGPPHPQ-L 660

Query: 1543 ETPKGANRKKNLPPKVPITP 1562
               +      NLP   P  P
Sbjct: 661  NKSQSLTNAFNLPEPAPPRP 680



 Score = 37.4 bits (85), Expect = 0.14
 Identities = 20/63 (31%), Positives = 28/63 (44%)

Query: 1650 GPGAHRPKGPAKTKGPRHQRKHHESITPPSRSPTKEAPPGLNDDAQIPASQESVATSVDG 1709
            GPG  R   P + + P   ++H   + PP+ SP  +  P      Q PASQ +  T   G
Sbjct: 471  GPGPQRQGPPLQQRPPPQGQQHLSGLGPPAGSPLPQRLPSPTSAPQQPASQAAPPTQGQG 530

Query: 1710 SDS 1712
              S
Sbjct: 531  RQS 533



 Score = 36.6 bits (83), Expect = 0.23
 Identities = 44/191 (23%), Positives = 68/191 (35%), Gaps = 17/191 (8%)

Query: 1371 RRFLKHSPPGPSFLNQTPAGEVVEVGDSDDEQEVASHQANRSPPLDSDPPIPIDDCCWHM 1430
            R+  + + PG     QTP+   + +G    +Q  A   A + PP    PP P        
Sbjct: 420  RQRQRDASPGRGSHGQTPSPGALPLGRQTSQQP-AGPPAQQRPPPQGGPPQPGPGPQRQG 478

Query: 1431 EPLS--PIPIDHWNLERTGPLSTSSPSRRMNEAADSRDCRSPGLLDTTPIRGSCTTQRKL 1488
             PL   P P    +L   GP + S   +R+     +   + P      P +G     R +
Sbjct: 479  PPLQQRPPPQGQQHLSGLGPPAGSPLPQRLPSPTSAP--QQPASQAAPPTQGQGRQSRPV 536

Query: 1489 QEKSSGAGSLGNSRPSFLNSALWDVWDGEEQRPPETPPPAQMPSAGGAQKPEGLETPKGA 1548
               + G G+   +RP    S          QR    P   +  S  G   P+    P G 
Sbjct: 537  ---AGGPGAPPAARPPASPSP---------QRQAGPPQATRQTSVSGPAPPKASGAPPGG 584

Query: 1549 NRKKNLPPKVP 1559
             +++  P K P
Sbjct: 585  QQRQGPPQKPP 595



 Score = 32.3 bits (72), Expect = 4.4
 Identities = 30/113 (26%), Positives = 39/113 (34%), Gaps = 10/113 (8%)

Query: 97  ATKTKTLQGPAEKKPPSGSQAPRTKKQRVTKWQASEPAHSVNGEGGVLASAPDP-PVLRE 155
           AT+  ++ GPA   PP  S AP   +QR        P     G  G    A    PV R 
Sbjct: 563 ATRQTSVSGPA---PPKASGAPPGGQQR------QGPPQKPPGPAGPTRQASQAGPVPRT 613

Query: 156 TAQNTQTGNQQEPSPNLSREKTRENVPNSDSQPPPSCLTTAVPSPSKPRTAQL 208
               TQ      P P    +      P+ D  PP +      P P   ++  L
Sbjct: 614 GPPTTQQPRPSGPGPAGRPKPQLAQKPSQDVPPPATAAAGGPPHPQLNKSQSL 666


>gi|91982772 mucin 17 [Homo sapiens]
          Length = 4493

 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 105/519 (20%), Positives = 181/519 (34%), Gaps = 53/519 (10%)

Query: 1246 SEASTTDTSWLVPATPLASRSRDCSSQT--QISSLRSGLAVQAVTQHTPRASVGNREGNE 1303
            SEAST  T+ +   TP+ + +   SS T  + +S+ +    +  T  T          + 
Sbjct: 644  SEASTLSTTPVDSNTPVTTSTEATSSSTTAEGTSMPTSTYTEGSTPLTSMPVNTTLVASS 703

Query: 1304 VAQKFSVIRPQTPPPQTPSSCLTPVSPGTSDGRRQGHRSPSRPHPGGHPHSSPLAPHPIS 1363
             A   S     T  P T S+  +  SP T+DG      +PS         S+PL   P+S
Sbjct: 704  EASTLSTTPVDTSTPVTTSTEASS-SPTTADGASMPTSTPSE-------GSTPLTSMPVS 755

Query: 1364 GDRAHFSRRFLKHSPPGPSFLNQTPAGEVVEVGDSDDEQEVASHQANRSPPLDSDPPIPI 1423
                  S      + P  +  + T + E      + +   +     +   PL +  P+ I
Sbjct: 756  KTLLTSSEASTLSTTPLDTSTHITTSTEASCSPTTTEGTSMPISTPSEGSPLLTSIPVSI 815

Query: 1424 DDCCWHMEPLSPIPIDHWNLERTGPLSTSSPSRRMNEAADSRDCRSPGLLDTTPIRGSCT 1483
                      +P+     +   T P+ ++SP     E + S           TP  G+  
Sbjct: 816  ----------TPVTSPEASTLSTTPVDSNSPVTTSTEVSSS----------PTPAEGTSM 855

Query: 1484 TQRKLQEKSSGAGSLGNSRPSFLNSALWDVWDGEEQRPPETPPPAQMPSAGGAQKPEGLE 1543
                  E  +   S+  S      SA+  +          TP     P     +      
Sbjct: 856  PTSTYSEGRTPLTSMPVSTTLVATSAISTL--------STTPVDTSTPVTNSTEARSSPT 907

Query: 1544 TPKGANRKKNLPPK--VPITPMPQYSIMETPVLKKELDRFGVRPLPKRQMVLKLKEIFQ- 1600
            T +G +   + P +   P+T MP  +   TPV+  E       P+     V    E    
Sbjct: 908  TSEGTSMPTSTPGEGSTPLTSMPDST---TPVVSSEARTLSATPVDTSTPVTTSTEATSS 964

Query: 1601 -YTHQTLDSDSEDESQSSQPLLQAPHCQTLA--SQTYKPSRAGVHAQQEATTGPGAHRPK 1657
              T +     +   S+ + PL   P   TL   S+    S   V +    TT   A  P 
Sbjct: 965  PTTAEGTSIPTSTPSEGTTPLTSTPVSHTLVANSEASTLSTTPVDSNTPLTTSTEASSPP 1024

Query: 1658 GPAK-TKGPRHQRKHHESITPPSRSPTKEAPPGLNDDAQIPASQESVATSVDGSDSSLSS 1716
              A+ T  P       E  TP +R P        ++ + +  +    +T V  +  S +S
Sbjct: 1025 PTAEGTSMPTSTPS--EGSTPLTRMPVSTTMVASSETSTLSTTPADTSTPV--TTYSQAS 1080

Query: 1717 QSSSSCEFGAAFESAGEEEGEGEVSASQAAVQAADTDEA 1755
             SS++ + G +  ++   EG   +++   + +   + EA
Sbjct: 1081 SSSTTAD-GTSMPTSTYSEGSTPLTSVPVSTRLVVSSEA 1118



 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 112/521 (21%), Positives = 167/521 (32%), Gaps = 85/521 (16%)

Query: 1243 SSPSEASTTDTSWLVPATPLASRSRDCSSQTQISSLRSGLAVQAVTQ------------- 1289
            S+PSE S   TS  V  TP+AS      S T + S    +    V+              
Sbjct: 1624 STPSEGSPLLTSIPVSTTPVASPEASTLSTTPVDSNSPVITSTEVSSSPTPAEGTSMPTS 1683

Query: 1290 -----HTPRASVGNREGNEVAQKFSVIRPQTPPPQTPSSCLTPV--SPGTSDGRRQGHRS 1342
                  TP  S+  R     +   S +        TP +  T    SP TS+G    + +
Sbjct: 1684 TYTEGRTPLTSITVRTTPVASSAISTLSTTPVDNSTPVTTSTEARSSPTTSEGTSMPNST 1743

Query: 1343 PSRPHPGGHPHSS-PLAPHPISGDRAHFSRRFLKHSPPGPSFLNQTPAGEVVEVGDSDDE 1401
            PS    G  P +S P++  P+    A              S L+ TP      V      
Sbjct: 1744 PSE---GTTPLTSIPVSTTPVLSSEA--------------STLSATPIDTSTPV------ 1780

Query: 1402 QEVASHQANRSPPLDSDPPIPIDDCCWHMEPLSPIPIDHWNL--ERTGPLSTSSPSRRMN 1459
                S +A  SP       IP       M PL+  P+ H  +       LST+       
Sbjct: 1781 --TTSTEATSSPTTAEGTSIPTSTLSEGMTPLTSTPVSHTLVANSEASTLSTTPVDSNSP 1838

Query: 1460 EAADSRDCRSPGLLDTTPIRGSCTTQRKLQEKSSGAGSLGNSRPSFLNSALWDVWDGEEQ 1519
                +    SP     TP  G+        E S+   S+  S  +  +S        E  
Sbjct: 1839 VVTSTAVSSSP-----TPAEGTSIATSTPSEGSTALTSIPVSTTTVASS--------ETN 1885

Query: 1520 RPPETPPPAQMPSAGGAQKPEGLETPKGANRKKNLP--PKVPITPMPQYSIMETPVLKKE 1577
                TP     P    AQ      T  G++   + P   + P+T +P   +  T V   E
Sbjct: 1886 TLSTTPAVTSTPVTTYAQVSSSPTTADGSSMPTSTPREGRPPLTSIP---VSTTTVASSE 1942

Query: 1578 LDRFGVRPLPKRQMVLKLKEIFQYTHQTLDSDSEDE---SQSSQPLLQAPHCQTLA---- 1630
            ++         R  V    +    +  T D  S      S+ S PL   P   TL     
Sbjct: 1943 INTLSTTLADTRTPVTTYSQA-SSSPTTADGTSMPTPAYSEGSTPLTSMPLSTTLVVSSE 2001

Query: 1631 --------SQTYKPSRAGVHAQQEATTGPGAH-RPKGPAKTKGPRHQRKHHESITPPSRS 1681
                      T  P+          TT  G   +   P++   P        ++   S  
Sbjct: 2002 ASTLSTTPVDTSTPATTSTEGSSSPTTAGGTSIQTSTPSERTTPLAGMPVSTTLVVSSEG 2061

Query: 1682 PTKEAPPGLNDDAQIPASQE-SVATSVDGSDSSLSSQSSSS 1721
             T    P ++   Q+  S E S + + +GS  ++S+ S  S
Sbjct: 2062 NTLSTTP-VDSKTQVTNSTEASSSATAEGSSMTISAPSEGS 2101



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 108/507 (21%), Positives = 168/507 (33%), Gaps = 74/507 (14%)

Query: 1243 SSPSEASTTDTSWLVPATPLASRSRDCSSQTQISSLRSGLAVQAVTQHTPRASVGNR--- 1299
            S+ SE ST  T   V  TP+ S +    S T + +  + +        +P  S G     
Sbjct: 3098 STYSEGSTPLTGVPVSTTPVTSSAISTLSTTPVDT-STPVTTSTEAHSSPTTSEGTSMPT 3156

Query: 1300 ----EGNE------VAQKFSVIRPQTPPPQTPSSCLTPVSPGT---SDGRRQGHRSP-SR 1345
                EG+       V+    V    +    TP    TPV+  T   S    +G   P S 
Sbjct: 3157 STPSEGSTPLTYMPVSTMLVVSSEDSTLSATPVDTSTPVTTSTEATSSTTAEGTSIPTST 3216

Query: 1346 PHPGGHPHSS-PLAPHPISGDRAHFSRRFLKHSPPGPSFLNQTPAGEVVEVGDSDDEQEV 1404
            P  G  P +S P++  P++   A              S L+ TP      +         
Sbjct: 3217 PSEGMTPLTSVPVSNTPVASSEA--------------SILSTTPVDSNTPL--------T 3254

Query: 1405 ASHQANRSPPLDSDPPIPIDDCCWHMEPLSPIPIDHWNL--ERTGPLSTSSPSRRMNEAA 1462
             S +A+ SPP      +P         PL+ +P+    +    T  LST+          
Sbjct: 3255 TSTEASSSPPTAEGTSMPTSTPSEGSTPLTSMPVSTTTVASSETSTLSTTPADTSTPVTT 3314

Query: 1463 DSRDCRSPGLLDTTPIRGSCTTQRK--LQEKSSGAGSLGNSRPSFLNSALWDVWDGEEQR 1520
             S+   SP + D T +  S  ++    L   S     + +S  S L++   D        
Sbjct: 3315 YSQASSSPPIADGTSMPTSTYSEGSTPLTNMSFSTTPVVSSEASTLSTTPVDT------- 3367

Query: 1521 PPETPPPAQMPSAGGAQKPEGLETPKGANRKKNLPPKVPITPMPQYSIMETPVLKKELDR 1580
               TP      ++      EG   P  +       P    TP+    +  TPV+  E++ 
Sbjct: 3368 --STPVTTSTEASLSPTTAEGTSIPTSS-------PSEGTTPLASMPVSTTPVVSSEVNT 3418

Query: 1581 FGVRPLPKRQMVLKLKE------IFQYTHQTLDSDSEDESQ-SSQPLLQAPHCQTLASQT 1633
                P+    +V    E      I + T     + SE  +  S  PL   P   + AS  
Sbjct: 3419 LSTTPVDSNTLVTTSTEASSSPTIAEGTSLPTSTTSEGSTPLSIMPLSTTPVASSEASTL 3478

Query: 1634 YKPSRAGVHAQQEATT-GPGAHRPKGPAKTKGPRHQRKHHESITPPSRSPTKEAPPGLND 1692
               S   V      TT  P    P     T  P       E  TP +  P    P   ++
Sbjct: 3479 ---STTPVDTSTPVTTSSPTNSSPTTAEVTSMPTSTA--GEGSTPLTNMPVSTTPVASSE 3533

Query: 1693 DAQIPASQESVATSVDGSDSSLSSQSS 1719
             + +  +     T V  S  + SS ++
Sbjct: 3534 ASTLSTTPVDSNTFVTSSSQASSSPAT 3560



 Score = 42.4 bits (98), Expect = 0.004
 Identities = 109/518 (21%), Positives = 168/518 (32%), Gaps = 78/518 (15%)

Query: 1243 SSPSEASTTDTSWLVPATPLASRSRDCSSQTQI--------SSLRSGLAVQAVTQHTPRA 1294
            S+PSE ST+ TS LV   P+AS      S T +        S+  S     A     P +
Sbjct: 2626 STPSEVSTSLTSILVSTMPVASSEASTLSTTPVDTRTLVTTSTGTSSSPTTAEGSSMPTS 2685

Query: 1295 SVGNRE-------------GNEVAQKFSVIRPQTPPPQTPSSCLTPVSPGTSDGRRQGHR 1341
            + G R               N  A   S     T  P T +S     SP T++G      
Sbjct: 2686 TPGERSTPLTNILVSTTLLANSEASTLSTTPVDTSTPVT-TSAEASSSPTTAEGTSMRIS 2744

Query: 1342 SPSRPHPGGHPHSSPL-APHPISGDRAHFSRRFLKHSPPGPSFLNQTPAGEVVEVGDSDD 1400
            +PS    G  P +S L +  P++   A              S ++ T     + V     
Sbjct: 2745 TPS---DGSTPLTSILVSTLPVASSEA--------------STVSTTAVDTSIPV----- 2782

Query: 1401 EQEVASHQANRSPPLDSDPPIPIDDCCWHMEPLSPIPIDHWNLERTGPLSTSSPSRRMNE 1460
                 S +A+ SP       +P         PL+ +P++H       P+++S        
Sbjct: 2783 ---TTSTEASSSPTTAEVTSMPTSTPSETSTPLTSMPVNH------TPVASSEAGTLSTT 2833

Query: 1461 AADSRDCRSPGLLDTTPIRGSCTTQRKLQEKSSGAGSLGNSRPSFLNSALWDVWDGEEQR 1520
              D+    S  +  +T    S TT   +    S A S G++  + +  +   V   E   
Sbjct: 2834 PVDT----STPVTTSTKASSSPTTAEGIVVPISTA-SEGSTLLTSIPVSTTPVASSEAST 2888

Query: 1521 PPETPPPAQMPSAGGAQKPEGLETPKGANRKKNLPPKVPITPMPQYSIMETPVLKKELDR 1580
               TP    +P     +      T +G +   + P +V  TP+    +   PV   E   
Sbjct: 2889 LSTTPVDTSIPVTTSTEGSSSPTTAEGTSMPISTPSEVS-TPLTSILVSTVPVAGSEAST 2947

Query: 1581 FGVRPLPKRQMVLKLKE------IFQYTHQTLDSDSE------DESQSSQPLL--QAPHC 1626
                P+  R  V    E        + T   + +  E        S S+ P+   +A   
Sbjct: 2948 LSTTPVDTRTPVTTSAEASSSPTTAEGTSMPISTPGERRTPLTSMSVSTMPVASSEASTL 3007

Query: 1627 QTLASQTYKPSRAGVHAQQEATTGPGAHRPKGPAKTKGPRHQRKHHESITP---PSRSPT 1683
                + T  P      A    TT  G   P     ++G         S TP   P  S  
Sbjct: 3008 SRTPADTSTPVTTSTEASSSPTTAEGTGIPIS-TPSEGSTPLTSIPVSTTPVAIPEASTL 3066

Query: 1684 KEAPPGLNDDAQIPASQESVATSVDGSDSSLSSQSSSS 1721
               P   N          S  T  +G+   +S+ S  S
Sbjct: 3067 STTPVDSNSPVVTSTEVSSSPTPAEGTSMPISTYSEGS 3104



 Score = 41.2 bits (95), Expect = 0.009
 Identities = 99/519 (19%), Positives = 159/519 (30%), Gaps = 67/519 (12%)

Query: 1241 RESSPSEASTTDTSWLVPATPLASRSRDCSSQTQISSLRSGLAVQAVTQHTPRASVGNRE 1300
            R S+PS+ ST  TS LV   P+AS      S T + +                 S+    
Sbjct: 2742 RISTPSDGSTPLTSILVSTLPVASSEASTVSTTAVDT-----------------SIPVTT 2784

Query: 1301 GNEVAQKFSVIRPQTPPPQTPSSCLTPVSPGTSDGRRQGHRSPSRPHPGGHPHSSPLAPH 1360
              E +   +     + P  TPS   TP++             P    P     +  L+  
Sbjct: 2785 STEASSSPTTAEVTSMPTSTPSETSTPLT-----------SMPVNHTPVASSEAGTLSTT 2833

Query: 1361 PISGDRAHFSRRFLKHSPPGPSFLNQTPAGEVVEVGDSDD-----------EQEVASHQA 1409
            P+       +      SP        T  G VV +  + +              VAS +A
Sbjct: 2834 PVDTSTPVTTSTKASSSP-------TTAEGIVVPISTASEGSTLLTSIPVSTTPVASSEA 2886

Query: 1410 NRSPPLDSDPPIPIDDCCWHMEPLSPIPIDHWNLERTGPLSTSSPSRRMNEAADSRDCRS 1469
            +       D  IP+          SP   +  ++  + P   S+P   +  +        
Sbjct: 2887 STLSTTPVDTSIPVTTSTEGSS--SPTTAEGTSMPISTPSEVSTPLTSILVSTVPVAGSE 2944

Query: 1470 PGLLDTTPIRGSCTTQRKLQEKSSGAGSLGNSRP-----------SFLNSALWDVWDGEE 1518
               L TTP+          +  SS   + G S P           + ++ +   V   E 
Sbjct: 2945 ASTLSTTPVDTRTPVTTSAEASSSPTTAEGTSMPISTPGERRTPLTSMSVSTMPVASSEA 3004

Query: 1519 QRPPETPPPAQMPSAGGAQKPEGLETPKGANRKKNLPPKVPITPMPQYSIMETPVLKKEL 1578
                 TP     P     +      T +G     + P +   TP+    +  TPV   E 
Sbjct: 3005 STLSRTPADTSTPVTTSTEASSSPTTAEGTGIPISTPSE-GSTPLTSIPVSTTPVAIPEA 3063

Query: 1579 DRFGVRPLPKRQMVLKLKEIFQ--YTHQTLDSDSEDESQSSQPLLQAPHCQT--LASQTY 1634
                  P+     V+   E+       +         S+ S PL   P   T   +S   
Sbjct: 3064 STLSTTPVDSNSPVVTSTEVSSSPTPAEGTSMPISTYSEGSTPLTGVPVSTTPVTSSAIS 3123

Query: 1635 KPSRAGVHAQQEATTGPGAHRPKGPAKTKGPRHQRK-HHESITPPSRSPTKEAPPGLNDD 1693
              S   V      TT   AH    P  ++G         E  TP +  P        ++D
Sbjct: 3124 TLSTTPVDTSTPVTTSTEAH--SSPTTSEGTSMPTSTPSEGSTPLTYMPVSTMLVVSSED 3181

Query: 1694 AQIPASQESVATSVDGSDSSLSSQSSSSCEFGAAFESAG 1732
            + + A+    +T V  S  + SS ++       +  S G
Sbjct: 3182 STLSATPVDTSTPVTTSTEATSSTTAEGTSIPTSTPSEG 3220



 Score = 40.4 bits (93), Expect = 0.016
 Identities = 105/479 (21%), Positives = 154/479 (32%), Gaps = 69/479 (14%)

Query: 1243 SSPSEASTTDTSWLVPATPLASRSRDCSSQTQISSLRSGLAVQAVTQHTPRASVGN---- 1298
            S+PSE S   TS  V  TP+ S      S T + S  S +        +P  + G     
Sbjct: 799  STPSEGSPLLTSIPVSITPVTSPEASTLSTTPVDS-NSPVTTSTEVSSSPTPAEGTSMPT 857

Query: 1299 ---REGN------EVAQKFSVIRPQTPPPQTPSSCLTPV--------SPGTSDGRRQGHR 1341
                EG        V+         +    TP    TPV        SP TS+G      
Sbjct: 858  STYSEGRTPLTSMPVSTTLVATSAISTLSTTPVDTSTPVTNSTEARSSPTTSEGTSM--- 914

Query: 1342 SPSRPHPGGHPHSS-PLAPHP-ISGDRAHFSRRFLKHSPP---------------GPSFL 1384
              S P  G  P +S P +  P +S +    S   +  S P               G S  
Sbjct: 915  PTSTPGEGSTPLTSMPDSTTPVVSSEARTLSATPVDTSTPVTTSTEATSSPTTAEGTSIP 974

Query: 1385 NQTPA-GEVVEVGDSDDEQEVASHQAN--RSPPLDSDPPIPIDDCCWHMEPLSPIP-IDH 1440
              TP+ G             VA+ +A+   + P+DS+ P+         E  SP P  + 
Sbjct: 975  TSTPSEGTTPLTSTPVSHTLVANSEASTLSTTPVDSNTPLTTS-----TEASSPPPTAEG 1029

Query: 1441 WNLERTGPLSTSSPSRRMNEAADSRDCRSPGLLDTTPIRGSCTTQRKLQEKSSGAGSLGN 1500
             ++  + P   S+P  RM  +           L TTP   S       Q  SS   + G 
Sbjct: 1030 TSMPTSTPSEGSTPLTRMPVSTTMVASSETSTLSTTPADTSTPVTTYSQASSSSTTADGT 1089

Query: 1501 SRPSFLNS-----------ALWDVWDGEEQRPPETPPPAQMPSAGGAQKPEGLETPKGAN 1549
            S P+   S           +   V   E      TP    +P     +      T +G +
Sbjct: 1090 SMPTSTYSEGSTPLTSVPVSTRLVVSSEASTLSTTPVDTSIPVTTSTEASSSPTTAEGTS 1149

Query: 1550 RKKNLPPKVPITPMPQYSIMETPVLKKELDRFGVRPLPKRQMVLKLKEIFQ--YTHQTLD 1607
               + PP    TP+    +  T V+  E +     P+  +  V    E      T +   
Sbjct: 1150 IPTS-PPSEGTTPLASMPVSTTLVVSSEANTLSTTPVDSKTQVATSTEASSPPPTAEVTS 1208

Query: 1608 SDSEDESQSSQPLLQAP--HCQTLASQTYKPSRAGVHAQQEATTGPGAHRPKGPAKTKG 1664
              +    + S PL   P  H    +S+    S + V      TT   A     P   +G
Sbjct: 1209 MPTSTPGERSTPLTSMPVRHTPVASSEASTLSTSPVDTSTPVTT--SAETSSSPTTAEG 1265



 Score = 38.1 bits (87), Expect = 0.079
 Identities = 112/519 (21%), Positives = 159/519 (30%), Gaps = 91/519 (17%)

Query: 1243 SSPSEASTTDTSWLVPATPLASRSR--------DCSSQTQISSLRSGLAVQAVTQHTPRA 1294
            S+PSE S + T   V   PL S           D S+    S+  S       +   P++
Sbjct: 150  STPSEESISSTMAFVSTAPLPSFEAYTSLTYKVDMSTPLTTSTQASSSPTTPESTTIPKS 209

Query: 1295 SVGNREGNEVAQKFSVIRPQTPPPQ------TPSSCLTPV--------SPGTSDGRRQGH 1340
            +  N EG+           +    +      TP    TPV        SP T++G    +
Sbjct: 210  T--NSEGSTPLTSMPASTMKVASSEAITLLTTPVEISTPVTISAQASSSPTTAEGPSLSN 267

Query: 1341 RSPSRPHPGGHPHSSPLAPHPISGDRAHFSRRFLKHSPPGPSFLNQTPAGEVVEVGDSDD 1400
             +PS    GG   S+PL   P+S      S           S L+ TPA   + V     
Sbjct: 268  SAPS----GG---STPLTRMPLSVMLVVSSEA---------STLSTTPAATNIPV----- 306

Query: 1401 EQEVASHQANRSPPLDSDPPIPIDDCCWHMEPLSPIPIDHWNLERTGPLSTSSPSRRMNE 1460
               + S +A+ SP       IP         PL+  P        T P++TS  S     
Sbjct: 307  ---ITSTEASSSPTTAEGTSIPTSTYTEGSTPLTSTPAS------TMPVATSEMSTLSIT 357

Query: 1461 AADSRDC----RSPGLLDTTPIRGSCTTQRKLQEKSSGAGSLGNSRPSFLNSALWDVWDG 1516
              D+         P  L TT    S  T       S G+  L N   S +  A       
Sbjct: 358  PVDTSTLVTTSTEPSSLPTTAEATSMLTSTL----SEGSTPLTNMPVSTILVA------S 407

Query: 1517 EEQRPPETPPPAQMPSAGGAQKPEGLETPKGANRKKNLPPKVPITPMPQYSIMETPVLKK 1576
             E     T P         A +     T           P    TP+    +  TPV   
Sbjct: 408  SEASTTSTIPVDSKTFVTTASEASSSPTTAEDTSIATSTPSEGSTPLTSMPVSTTPVASS 467

Query: 1577 ELDRFGVRPLPKRQMVLKLKEIFQY--THQTLDSDSEDESQSSQPLL------------Q 1622
            E       P+  +  V    E      T +     +   S+ S PL             +
Sbjct: 468  EASNLSTTPVDSKTQVTTSTEASSSPPTAEVNSMPTSTPSEGSTPLTSMSVSTMPVASSE 527

Query: 1623 APHCQTLASQTYKPSRAGVHAQQEATTGPGAHRPKG-PAKTKGPRHQRKHHESITPPSRS 1681
            A    T    T  P      A   +TT  G   P   P++   P         +   S +
Sbjct: 528  ASTLSTTPVDTSTPVTTSSEASSSSTTPEGTSIPTSTPSEGSTPLTNMPVSTRLVVSSEA 587

Query: 1682 PTKEAPPGLNDDAQIPASQESVATSVDGSDSSLSSQSSS 1720
             T    P          S   V TS + S SS +++ +S
Sbjct: 588  STTSTTPA--------DSNTFVTTSSEASSSSTTAEGTS 618



 Score = 37.7 bits (86), Expect = 0.10
 Identities = 108/524 (20%), Positives = 159/524 (30%), Gaps = 90/524 (17%)

Query: 1243 SSPSEASTTDTSWLVPATPLASRSRDCSSQTQISS---------------LRSGLAVQAV 1287
            S+PSE S   TS  +  TP+AS      S T + S                  G ++Q  
Sbjct: 2095 SAPSEGSPLLTSIPLSTTPVASPEASTLSTTPVDSNSPVITSTEVSSSPIPTEGTSMQTS 2154

Query: 1288 TQHTPRASVGNREGNEVAQKFSVIRPQTPPPQTPSSCLT-----PVSPGTSDGRRQGHRS 1342
            T    R  + +   +      S I   +  P   S+ +T       SP TS+G      +
Sbjct: 2155 TYSDRRTPLTSMPVSTTVVASSAISTLSTTPVDTSTPVTNSTEARSSPTTSEGTSMPTST 2214

Query: 1343 PSRPHPGGHPHSS-PLAPHPISGDRAHFSRRFLKHSPPGPSFLNQTPAGEVVEVGDSDDE 1401
            PS    G  P +S P++  P+    A              S L+ TP      V      
Sbjct: 2215 PSE---GSTPFTSMPVSTMPVVTSEA--------------STLSATPVDTSTPV------ 2251

Query: 1402 QEVASHQANRSPPLDSDPPIPIDDCCWHMEPLSPIPIDHW---NLE----RTGPLSTSSP 1454
                S +A  SP       IP         PL+ IP+ H    N E     T P+ +++P
Sbjct: 2252 --TTSTEATSSPTTAEGTSIPTSTLSEGTTPLTSIPVSHTLVANSEVSTLSTTPVDSNTP 2309

Query: 1455 SRRMNEAADSRDCRSPGLLDTTPIRGSCTTQRKLQEKSSGAGSLGNSRPSFLNSALWDVW 1514
                 EA+          + T+      T   ++   ++   S   S  S          
Sbjct: 2310 FTTSTEASSPPPTAEGTSMPTSTSSEGNTPLTRMPVSTTMVASFETSTLS---------- 2359

Query: 1515 DGEEQRPPETPPPAQMPSAGGAQKPEGLETPKGANRKKNLPPKVPITPMPQYSIMETPVL 1574
                  P +T  P    S  G+      +T    +         P+T +P   +   PV+
Sbjct: 2360 ----TTPADTSTPVTTYSQAGSSPTTADDTSMPTSTYSE--GSTPLTSVP---VSTMPVV 2410

Query: 1575 KKELDRFGVRPLPKRQMVLKLKEIFQ--YTHQTLDSDSEDESQSSQPLLQAP-------- 1624
              E       P+     V    E      T +     +   S+ + PL   P        
Sbjct: 2411 SSEASTHSTTPVDTSTPVTTSTEASSSPTTAEGTSIPTSPPSEGTTPLASMPVSTTPVVS 2470

Query: 1625 ----HCQTLASQTYKPSRAGVHAQQEATTGPGAHRPKGPAKTKGPRHQRKHHESITP--- 1677
                   T    T  P      A    TT      P   A ++G         S TP   
Sbjct: 2471 SEAGTLSTTPVDTSTPMTTSTEASSSPTTAEDIVVPISTA-SEGSTLLTSIPVSTTPVAS 2529

Query: 1678 PSRSPTKEAPPGLNDDAQIPASQESVATSVDGSDSSLSSQSSSS 1721
            P  S     P   N          S ATS +G+    S+ S  S
Sbjct: 2530 PEASTLSTTPVDSNSPVVTSTEISSSATSAEGTSMPTSTYSEGS 2573



 Score = 37.4 bits (85), Expect = 0.14
 Identities = 99/526 (18%), Positives = 176/526 (33%), Gaps = 67/526 (12%)

Query: 1246 SEASTTDTSWLVPATPLASRSRDCSSQTQISSLRSGLAVQAVTQHTPRASVGNREGNEVA 1305
            SEAST  T+ +  +TP+ + +   SS T         +  +    TP  S+   +    +
Sbjct: 703  SEASTLSTTPVDTSTPVTTSTEASSSPTTADGASMPTSTPS-EGSTPLTSMPVSKTLLTS 761

Query: 1306 QKFSVIRPQTPPPQTPSSCLTPVSPGTSDGRRQGHRSPSRPHPGGHP--HSSPLAPHPIS 1363
             + S +   T P  T +   T      S    +G   P      G P   S P++  P++
Sbjct: 762  SEASTL--STTPLDTSTHITTSTEASCSPTTTEGTSMPISTPSEGSPLLTSIPVSITPVT 819

Query: 1364 GDRAHFSRRFLKHSPPGPSFLNQTPAGEVVEVGDSDDEQEVASHQANRSPPLDSDPPIPI 1423
                           P  S L+ TP           +     S + + SP       +P 
Sbjct: 820  S--------------PEASTLSTTPV--------DSNSPVTTSTEVSSSPTPAEGTSMPT 857

Query: 1424 DDCCWHMEPLSPIPIDHWNLERTGPLSTSSPSRRMNEAADSRDCRSPGLLDTTPIRGSCT 1483
                    PL+ +P+       T  ++TS+ S       D+    S  + ++T  R S T
Sbjct: 858  STYSEGRTPLTSMPVS------TTLVATSAISTLSTTPVDT----STPVTNSTEARSSPT 907

Query: 1484 TQRKLQEKSSGAGSLGNSRPSFLNSALWDVWDGEEQRPPETPPPAQMPSAGGAQKPEGLE 1543
            T       +S  G  G++  + +  +   V   E +    TP     P     +      
Sbjct: 908  TSEGTSMPTSTPGE-GSTPLTSMPDSTTPVVSSEARTLSATPVDTSTPVTTSTEATSSPT 966

Query: 1544 TPKGANRKKNLPPKVPITPMPQYSIMETPVLKKELDRFGVRPLPKRQMVLKLKEIFQ--Y 1601
            T +G +   + P +   TP+    +  T V   E       P+     +    E      
Sbjct: 967  TAEGTSIPTSTPSE-GTTPLTSTPVSHTLVANSEASTLSTTPVDSNTPLTTSTEASSPPP 1025

Query: 1602 THQTLDSDSEDESQSSQPLLQAPHCQTLA------------SQTYKPSRAGVHAQQEATT 1649
            T +     +   S+ S PL + P   T+             + T  P      A   +TT
Sbjct: 1026 TAEGTSMPTSTPSEGSTPLTRMPVSTTMVASSETSTLSTTPADTSTPVTTYSQASSSSTT 1085

Query: 1650 GPGAHRPKGPAKTKGPRHQRKHHESITPPSRSPTKEAPPGLNDDAQIPASQESVATSVDG 1709
              G   P              + E  TP +  P        ++ + +  S   V TS+  
Sbjct: 1086 ADGTSMPTS-----------TYSEGSTPLTSVPVSTRLVVSSEASTL--STTPVDTSIPV 1132

Query: 1710 SDSSLSSQSSSSCEFGAAFESAGEEEGEGEVSASQAAVQAADTDEA 1755
            + S+ +S S ++ E G +  ++   EG   +++   +     + EA
Sbjct: 1133 TTSTEASSSPTTAE-GTSIPTSPPSEGTTPLASMPVSTTLVVSSEA 1177



 Score = 34.3 bits (77), Expect = 1.1
 Identities = 101/516 (19%), Positives = 158/516 (30%), Gaps = 82/516 (15%)

Query: 1243 SSPSEASTTDTSWLVPATPLASRSRDCSSQTQISSLRSGLAVQAVTQHTPRASVGNREGN 1302
            S+PSE +T  TS  V  TP+ S      S T + +   G      T     +S    EG 
Sbjct: 1389 SNPSEGTTPLTSIPVSTTPVVSSEASTLSATPVDTSTPG-----TTSAEATSSPTTAEGI 1443

Query: 1303 EVAQKFSVIRPQTPPPQTPSSCLTPVSPGTSDGRRQGHRSPSRPHPGGHPHSSPLAPHPI 1362
             +            P  TPS   TP+              P    P  +  +S L+  P+
Sbjct: 1444 SI------------PTSTPSEGKTPLK-----------SIPVSNTPVANSEASTLSTTPV 1480

Query: 1363 SGDRAHFSRRFLKHSP---PGPSFLNQTPA-GEVVEVGDSDDEQEVASHQANRSPPLDSD 1418
              +    +   +  SP    G S    TP+ G             VAS + N      + 
Sbjct: 1481 DSNSPVVTSTAVSSSPTPAEGTSIAISTPSEGSTALTSIPVSTTTVASSEINSLSTTPAV 1540

Query: 1419 PPIPIDDCCWHMEPLSPIPIDHWNLERTGPLSTSSPSRRMNEAADSRDCRSPGLLDTTPI 1478
               P+    +     SP   D  +++ +     S+P   +  +           L TTPI
Sbjct: 1541 TSTPV--TTYSQASSSPTTADGTSMQTSTYSEGSTPLTSLPVSTMLVVSSEANTLSTTPI 1598

Query: 1479 RGSCTTQRKLQEKSS---GAGSLGNSRPSFLNSALWDVWDGEEQRPPETPPPAQMPSAGG 1535
                      +  SS      S+  S PS  +  L  +       P  T P A   ++  
Sbjct: 1599 DSKTQVTASTEASSSTTAEGSSMTISTPSEGSPLLTSI-------PVSTTPVASPEASTL 1651

Query: 1536 AQKPEGLETPKGANRKKNLPP------KVPI-------TPMPQYSIMETPVLKKELDRFG 1582
            +  P    +P   + + +  P       +P        TP+   ++  TPV    +    
Sbjct: 1652 STTPVDSNSPVITSTEVSSSPTPAEGTSMPTSTYTEGRTPLTSITVRTTPVASSAISTLS 1711

Query: 1583 VRPLPKRQMVLKLKEI--FQYTHQTLDSDSEDESQSSQPLLQAP---------HCQTLAS 1631
              P+     V    E      T +     +   S+ + PL   P            TL++
Sbjct: 1712 TTPVDNSTPVTTSTEARSSPTTSEGTSMPNSTPSEGTTPLTSIPVSTTPVLSSEASTLSA 1771

Query: 1632 ---QTYKPSRAGVHAQQEATTGPGAHRPKG-------PAKTKGPRHQRKHHESITPPSRS 1681
                T  P      A    TT  G   P         P  +    H    +   +  S +
Sbjct: 1772 TPIDTSTPVTTSTEATSSPTTAEGTSIPTSTLSEGMTPLTSTPVSHTLVANSEASTLSTT 1831

Query: 1682 PTKEAPPGLNDDA----QIPASQESVATSVDGSDSS 1713
            P     P +   A      PA   S+ATS     S+
Sbjct: 1832 PVDSNSPVVTSTAVSSSPTPAEGTSIATSTPSEGST 1867


>gi|164419758 bromodomain containing 2 [Homo sapiens]
          Length = 801

 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 87/373 (23%), Positives = 137/373 (36%), Gaps = 57/373 (15%)

Query: 907  EPLEPGRDEAATTWEKMGQCALPPPQGQHSGARGAE------APEQEAPEEALGHSSCSS 960
            EPLEPG    +T        A+PP   + S    +E      + E+E  E+        S
Sbjct: 456  EPLEPGPLPVST--------AMPPGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEEES 507

Query: 961  PSRDCQAERKEGSLPHSDDA-GDYEQLFSSTQGEISEPSQITSEPEEQS--GAVRERGLE 1017
             S D + ER        +     +EQL + +QG IS+P +   + E++    A + RG  
Sbjct: 508  ESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKREKKEKKKKRKAEKHRGRA 567

Query: 1018 VSHR--LAPWQASPPHPCRFLLGPPQGG-----SPRGSHHTSGSSLSTPRSRGGTSQVGS 1070
             +      P    PP P +       GG      P G   + GS    P+    T+    
Sbjct: 568  GADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGPSGGSGTKLPKKATKTAPPAL 627

Query: 1071 PTLL-------SPAVPSKQKRDRSILTLSKEPGHQKGKERRSVLECRNKGVLMFPEKSPS 1123
            PT         S  +   +KR  S L ++K PG + G+            V +   + PS
Sbjct: 628  PTGYDSEEEEESRPMSYDEKRQLS-LDINKLPGEKLGRV-----------VHIIQAREPS 675

Query: 1124 IDLTQSNPD--HSSSRSQKSSSKLNEEDEVILLLDSDEELELEQTKMKSISSDPLEEKKA 1181
              L  SNP+       + K S+    E  V+  L           K    + + L  +K 
Sbjct: 676  --LRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKPVGKTKEELALEKK 733

Query: 1182 LEISPRSCELFSIIDVDADQEPSQSPPRSEAVLQQEDEGALPENRGSLGRRGAPWLFCDR 1241
             E+  R      + DV      ++ PP+       E   +    + ++ R  A     D 
Sbjct: 734  RELEKR------LQDVSGQLNSTKKPPKK----ANEKTESSSAQQVAVSRLSASSSSSDS 783

Query: 1242 ESSPSEASTTDTS 1254
             SS S +S++DTS
Sbjct: 784  SSSSSSSSSSDTS 796



 Score = 35.4 bits (80), Expect = 0.51
 Identities = 50/232 (21%), Positives = 84/232 (36%), Gaps = 21/232 (9%)

Query: 24  PGIDPRSSEDQPE------SLKTGQMMDESDEDFKELCASFFQRVKKHGIKEVSGE---- 73
           PG+   SSE   E      S +  +  DE DE+ +E  +S  +  + H + E+  +    
Sbjct: 471 PGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAV 530

Query: 74  RKTQKAASNGTQIRSKLKRTKQTATKTKTLQ-------GPAEKKPPSGSQAPRTKKQRVT 126
            +   A S G   + K KR K+   K +  +          + K P   + P+ KK +  
Sbjct: 531 HEQLAALSQGPISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSK-- 588

Query: 127 KWQASEPAHSVNGEGGVLASAPDPPVLRETAQNTQTGNQQEPSPNLSREKTRENVPNSDS 186
           K   S    +  G  G   S      L + A  T+T     P+   S E+      + D 
Sbjct: 589 KASGSGGGSAALGPSGFGPSGGSGTKLPKKA--TKTAPPALPTGYDSEEEEESRPMSYDE 646

Query: 187 QPPPSCLTTAVPSPSKPRTAQLVLQRMQQFKRADPERLRHASEECSLEAARE 238
           +   S     +P     R   ++  R    + ++PE +    E       RE
Sbjct: 647 KRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRE 698



 Score = 33.5 bits (75), Expect = 2.0
 Identities = 30/103 (29%), Positives = 41/103 (39%), Gaps = 12/103 (11%)

Query: 1666 RHQRKHHESITPPSRSPTKEAPPGLNDDAQIPASQESVATSVDGSDSSLSSQSSSSCEFG 1725
            R+ +   E + P     +   PPGL   +   +S+ES            SS+SSS  E  
Sbjct: 449  RYAKMPDEPLEPGPLPVSTAMPPGLAKSSSESSSEES------------SSESSSEEEEE 496

Query: 1726 AAFESAGEEEGEGEVSASQAAVQAADTDEALRCYIRSKPALYQ 1768
               E   EEE E   S  + A + A+  E LR       AL Q
Sbjct: 497  EDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQ 539


>gi|4826806 bromodomain containing 2 [Homo sapiens]
          Length = 801

 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 87/373 (23%), Positives = 137/373 (36%), Gaps = 57/373 (15%)

Query: 907  EPLEPGRDEAATTWEKMGQCALPPPQGQHSGARGAE------APEQEAPEEALGHSSCSS 960
            EPLEPG    +T        A+PP   + S    +E      + E+E  E+        S
Sbjct: 456  EPLEPGPLPVST--------AMPPGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEEES 507

Query: 961  PSRDCQAERKEGSLPHSDDA-GDYEQLFSSTQGEISEPSQITSEPEEQS--GAVRERGLE 1017
             S D + ER        +     +EQL + +QG IS+P +   + E++    A + RG  
Sbjct: 508  ESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKREKKEKKKKRKAEKHRGRA 567

Query: 1018 VSHR--LAPWQASPPHPCRFLLGPPQGG-----SPRGSHHTSGSSLSTPRSRGGTSQVGS 1070
             +      P    PP P +       GG      P G   + GS    P+    T+    
Sbjct: 568  GADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGPSGGSGTKLPKKATKTAPPAL 627

Query: 1071 PTLL-------SPAVPSKQKRDRSILTLSKEPGHQKGKERRSVLECRNKGVLMFPEKSPS 1123
            PT         S  +   +KR  S L ++K PG + G+            V +   + PS
Sbjct: 628  PTGYDSEEEEESRPMSYDEKRQLS-LDINKLPGEKLGRV-----------VHIIQAREPS 675

Query: 1124 IDLTQSNPD--HSSSRSQKSSSKLNEEDEVILLLDSDEELELEQTKMKSISSDPLEEKKA 1181
              L  SNP+       + K S+    E  V+  L           K    + + L  +K 
Sbjct: 676  --LRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKPVGKTKEELALEKK 733

Query: 1182 LEISPRSCELFSIIDVDADQEPSQSPPRSEAVLQQEDEGALPENRGSLGRRGAPWLFCDR 1241
             E+  R      + DV      ++ PP+       E   +    + ++ R  A     D 
Sbjct: 734  RELEKR------LQDVSGQLNSTKKPPKK----ANEKTESSSAQQVAVSRLSASSSSSDS 783

Query: 1242 ESSPSEASTTDTS 1254
             SS S +S++DTS
Sbjct: 784  SSSSSSSSSSDTS 796



 Score = 35.4 bits (80), Expect = 0.51
 Identities = 50/232 (21%), Positives = 84/232 (36%), Gaps = 21/232 (9%)

Query: 24  PGIDPRSSEDQPE------SLKTGQMMDESDEDFKELCASFFQRVKKHGIKEVSGE---- 73
           PG+   SSE   E      S +  +  DE DE+ +E  +S  +  + H + E+  +    
Sbjct: 471 PGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAV 530

Query: 74  RKTQKAASNGTQIRSKLKRTKQTATKTKTLQ-------GPAEKKPPSGSQAPRTKKQRVT 126
            +   A S G   + K KR K+   K +  +          + K P   + P+ KK +  
Sbjct: 531 HEQLAALSQGPISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSK-- 588

Query: 127 KWQASEPAHSVNGEGGVLASAPDPPVLRETAQNTQTGNQQEPSPNLSREKTRENVPNSDS 186
           K   S    +  G  G   S      L + A  T+T     P+   S E+      + D 
Sbjct: 589 KASGSGGGSAALGPSGFGPSGGSGTKLPKKA--TKTAPPALPTGYDSEEEEESRPMSYDE 646

Query: 187 QPPPSCLTTAVPSPSKPRTAQLVLQRMQQFKRADPERLRHASEECSLEAARE 238
           +   S     +P     R   ++  R    + ++PE +    E       RE
Sbjct: 647 KRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRE 698



 Score = 33.5 bits (75), Expect = 2.0
 Identities = 30/103 (29%), Positives = 41/103 (39%), Gaps = 12/103 (11%)

Query: 1666 RHQRKHHESITPPSRSPTKEAPPGLNDDAQIPASQESVATSVDGSDSSLSSQSSSSCEFG 1725
            R+ +   E + P     +   PPGL   +   +S+ES            SS+SSS  E  
Sbjct: 449  RYAKMPDEPLEPGPLPVSTAMPPGLAKSSSESSSEES------------SSESSSEEEEE 496

Query: 1726 AAFESAGEEEGEGEVSASQAAVQAADTDEALRCYIRSKPALYQ 1768
               E   EEE E   S  + A + A+  E LR       AL Q
Sbjct: 497  EDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQ 539


>gi|46370071 GRB2-associated binding protein 1 isoform a [Homo
            sapiens]
          Length = 724

 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 52/211 (24%), Positives = 80/211 (37%), Gaps = 37/211 (17%)

Query: 1243 SSPSEASTTDTSWLVPATPLASRSRDCSSQTQISSLRSGLAVQAVTQHTPRA-------- 1294
            S P  AS TD+S+ +P   ++    +  S   ++ LR   + Q      PRA        
Sbjct: 361  SIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYD-IPRAFPSDRSSS 419

Query: 1295 --------------SVGNREGNEVAQKFSVIRPQTPPPQTPSSCLTPV--------SPGT 1332
                          +VG+    E+ + +  + P +PP Q  SS   P+        +PGT
Sbjct: 420  LEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGT 479

Query: 1333 SDGRRQGHRSPSRPHPG--GHPHSSPLAPHPISGDRAHFSRRFLKHSPPG--PSFLNQTP 1388
             D    G + P   H G    P + P  P P++        R LK    G  P  L   P
Sbjct: 480  FDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKGQSPKILRLKP 539

Query: 1389 AGEVVEVGDSDDEQEVASHQANRSPPLDSDP 1419
             G  +E  DS    + A+ +  +  PL+  P
Sbjct: 540  HG--LERTDSQTIGDFATRRKVKPAPLEIKP 568


>gi|4557445 regulator of chromosome condensation and BTB domain
           containing protein 2 [Homo sapiens]
          Length = 551

 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 36/104 (34%), Positives = 51/104 (49%), Gaps = 12/104 (11%)

Query: 686 NNPHLSDVQFQTDSGEVLYAHKFVLYARCPLLIQYVNNEGF-SAVEDGVLTQRVLLGDVS 744
           +NP  +D++F  D G+ +YAHK +L  RC         E F S++ED      V + + S
Sbjct: 389 DNPDTADLKFLVD-GKYIYAHKVLLKIRC---------EHFRSSLEDNE-DDIVEMSEFS 437

Query: 745 TEAARTFLHYLYTADTGLPPGLSSELSSLAHRFGVSELVHLCEQ 788
               R FL YLYT    L P  +  L  LA  +  + L  LC+Q
Sbjct: 438 YPVYRAFLEYLYTDSISLSPEEAVGLLDLATFYRENRLKKLCQQ 481


>gi|211904190 hypothetical protein LOC149478 [Homo sapiens]
          Length = 291

 Score = 45.1 bits (105), Expect = 6e-04
 Identities = 34/107 (31%), Positives = 49/107 (45%), Gaps = 6/107 (5%)

Query: 683 AMVNNPHLSDVQFQT-DSGEVLYAHKFVLYARCPLLIQYVNNEGFSAVEDGVLTQRVLLG 741
           ++VNNP  SDV F      + ++AH+ +L  RC    + +  E    V   V+     L 
Sbjct: 21  SLVNNPRYSDVCFVVGQERQEVFAHRCLLACRCNFFQRLLGTEPGPGVPSPVV-----LS 75

Query: 742 DVSTEAARTFLHYLYTADTGLPPGLSSELSSLAHRFGVSELVHLCEQ 788
            V TEA    L +LYT    L      E+ + A  +G+ EL  LC Q
Sbjct: 76  TVPTEAFLAVLEFLYTNSVKLYRHSVLEVLTAAVEYGLEELRELCLQ 122


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score = 44.7 bits (104), Expect = 8e-04
 Identities = 40/167 (23%), Positives = 61/167 (36%), Gaps = 25/167 (14%)

Query: 91  KRTKQTATKTKTLQGPAEKKPPSGSQAPRTKKQRVTKWQASEPAHSVNGEGGVLASAPDP 150
           K    T TK  +   P E  P +   AP T K         EPA +           P P
Sbjct: 370 KEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTK---------EPAPTTTKSAPTTPKEPSP 420

Query: 151 PVLRETAQNTQTGNQQEPSPNLSREKT----RENVPNSDSQPPPSCLTTAVPSPSKPR-- 204
              +E A  T     +EP+P   ++      +E  P +  +P P+  TT  P+P+ P+  
Sbjct: 421 TTTKEPAPTT----PKEPAPTTPKKPAPTTPKEPAPTTPKEPAPT--TTKKPAPTTPKEP 474

Query: 205 ----TAQLVLQRMQQFKRADPERLRHASEECSLEAAREENVPKDPQE 247
                 +      ++     PE+L   + E       EE  P  P+E
Sbjct: 475 APTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEE 521



 Score = 36.2 bits (82), Expect = 0.30
 Identities = 31/116 (26%), Positives = 46/116 (39%), Gaps = 15/116 (12%)

Query: 91  KRTKQTATKTKTLQGPAEKKPPSGSQAPRTKKQRVTKWQASEPAHSVNGEGGVLASAPDP 150
           K    T  K  T   P E  P +   AP T K+        +PA +   E       P P
Sbjct: 315 KEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPT-APKKPAPTTPKE-------PAP 366

Query: 151 PVLRETAQNTQTGNQQEPSPNLSRE---KTRENVPNSDSQPPPSCLTTAVPSPSKP 203
              +E A  T     +EPSP   +E    T ++ P +  +P P+   +A  +P +P
Sbjct: 367 TTPKEPAPTT----TKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEP 418



 Score = 35.4 bits (80), Expect = 0.51
 Identities = 143/784 (18%), Positives = 243/784 (30%), Gaps = 125/784 (15%)

Query: 996  EPSQITSEPEEQSGAVRERGLEVSHRLAPWQASPPHPCRFLLGPPQGGSPRGSHHTSGS- 1054
            EP+  T  P+E +    +     + + AP   +P  P       P   +P+    T+   
Sbjct: 269  EPAPTT--PKEPAPTTTKEPAPTTTKSAP--TTPKEPAPTTPKKPAPTTPKEPAPTTPKE 324

Query: 1055 -SLSTPRSRGGTSQVGSPTLLSPAVPSKQKRDRSILTLSKEPGHQKGKERRSVLECRNKG 1113
             + +TP+    T++  +PT      P+  K+     T  KEP     KE           
Sbjct: 325  PTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAP--TTPKEPAPTTPKEPAPTTT----- 377

Query: 1114 VLMFPEKSPSIDLTQSNPDHSSSRSQKSSSKLNEEDEVILLLDSDEELELEQTKMKSISS 1173
                 E SP+   T   P  ++++S  +++K                 E   T  KS  +
Sbjct: 378  ----KEPSPT---TPKEPAPTTTKSAPTTTK-----------------EPAPTTTKSAPT 413

Query: 1174 DPLEEKKALEISPRSCELFSIIDVDADQEPSQSPPRSEAVLQQEDEGALPENRGSLGRRG 1233
             P E        P              +EP+ + P+  A    ++         +     
Sbjct: 414  TPKEPSPTTTKEPAPT---------TPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK 464

Query: 1234 APWLFCDRE---SSPSEASTTDTSWLVPATPLASRSRDCSSQTQISSLRSGLAVQAVTQH 1290
             P     +E   ++P E + T    L P TP   +    + +    +    LA     + 
Sbjct: 465  KPAPTTPKEPAPTTPKETAPTTPKKLTPTTP--EKLAPTTPEKPAPTTPEELAPTTPEEP 522

Query: 1291 TPRASVGNREGNEVAQKFSVIRPQTPPPQTPSSCL--TPVSPGTSDGRRQGHRSPSRPHP 1348
            TP                    P+ P P TP +    TP  P  +  +     +P  P P
Sbjct: 523  TPTT------------------PEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAP 564

Query: 1349 GGHPHSSPLAPHPISGDRAHFSRRFLKHSP--PGPSFLNQTPAGEVVEVGDSDDEQEVAS 1406
                 ++P  P    G      +     +P  P P  L  T   E               
Sbjct: 565  TTPKETAPTTP---KGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPK 621

Query: 1407 HQANRSP-------PLDSDPPIPIDDCCWHME------PLSPIPIDHWNLERTGPLSTSS 1453
              A  +P       P +  P  P       ++      P  P P +       GP ST+S
Sbjct: 622  GTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTS 681

Query: 1454 ------------PSRRMNEAADSRDCRSPGLLDTTPIRGS-CTTQRKLQEKSSGAGSLGN 1500
                        P+     A  +    +P   +T P   S  +T    +E ++   S   
Sbjct: 682  DKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDE 741

Query: 1501 SRPSFLNSALWDVWDGEEQRP--PETPPPAQMPSAGGAQKPEGLETPKGANRKKNLPPKV 1558
            S P           +   + P  P T  PA       A KPE   T K    +++L    
Sbjct: 742  STPELSAEPTPKALENSPKEPGVPTTKTPA-------ATKPEMTTTAKDKTTERDLRTTP 794

Query: 1559 PITPMPQYSIMETPVLKKELDRFGVRPLPKRQMVLKLKEIFQYTHQTLDSDS-EDESQSS 1617
              T        ET    ++     +     +      ++   +   TL + +   +  ++
Sbjct: 795  ETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTT 854

Query: 1618 QPLLQAPHCQTLASQTYKPSRAGVHAQQEATTGPGAHRP----KGPAKTKGPRHQRKHHE 1673
            +  +          +T KP     +++    T P   +P    K P  TK P+   +  +
Sbjct: 855  KKTITTTEIMNKPEETAKPKDRATNSK---ATTPKPQKPTKAPKKPTSTKKPKTMPRVRK 911

Query: 1674 SITPPSRSPTKEAPPGLNDDAQIPASQESVATSVDGSDSSLSSQSSSSCEFGAAFESAGE 1733
              T P+        P LN  ++I  +     T  +       + +S   E     E AG 
Sbjct: 912  PKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPN------QTPNSKLVEVNPKSEDAGG 965

Query: 1734 EEGE 1737
             EGE
Sbjct: 966  AEGE 969



 Score = 35.0 bits (79), Expect = 0.67
 Identities = 96/510 (18%), Positives = 169/510 (33%), Gaps = 98/510 (19%)

Query: 93   TKQTATKTKTLQGPAE---KKPPSGSQAPRTKKQRVTKWQASEPAHSV-NGEGGVLASAP 148
            T    T   TL+ PA    KKP     AP T K+  T     +PA +   G        P
Sbjct: 573  TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKE-PTSTTCDKPAPTTPKGTAPTTPKEP 631

Query: 149  DPPVLRETAQNTQTGNQ----QEPSPNLSREKT-------------------------RE 179
             P   +E A  T  G      +EP+P   ++                           +E
Sbjct: 632  APTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKE 691

Query: 180  NVPNSDSQPPPSCLTTAVPSPSKPRTAQLVLQRMQ-QFKRADPERLRHASEECSLEAARE 238
              P +  +P P+  T   P+P+ P T       +       +P  +  + +E + E + E
Sbjct: 692  TAPTTPKEPAPT--TPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAE 749

Query: 239  ------ENVPKDPQEEMMAGNVYGLGPPAPESDAAVALTLQQEFARVGASAHDDSLEEKG 292
                  EN PK+P            G P  ++ AA           +  +A D + E   
Sbjct: 750  PTPKALENSPKEP------------GVPTTKTPAATK-------PEMTTTAKDKTTERD- 789

Query: 293  LFFCQICQKNLSAMNVTRREQHVNRCLDEAEKTLRPS-VPQIPECPICGKPFLTLKSRTS 351
                   +   +A  +T+          E++ T   + V              TLK+ T 
Sbjct: 790  --LRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTL 847

Query: 352  HLKQCAVKMEVGPQLLLQAVRLQTAQPEGSSSPPMFSFSDHSRGLKR-RGPTSKKEPRKR 410
              K    K  +    ++     +TA+P+  ++    +     +  K  + PTS K+P+  
Sbjct: 848  APKVTTTKKTITTTEIMNKPE-ETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTM 906

Query: 411  RKVDEAPSEDLLVAMALSRSEMEPGAAVPALRLESAFSERIRP----------------- 453
             +V +  +      M  +  E+ P + +    L++       P                 
Sbjct: 907  PRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPKSEDAGGA 966

Query: 454  EAENKSRKKKPPVSPPLLLVQDSETTGRQIEDRVAL--LLSEEVELSSTPPLPASRILKE 511
            E E      +P V  P  +  D +   R     + +  +LS+E  + +  P+     L+ 
Sbjct: 967  EGETPHMLLRPHVFMP-EVTPDMDYLPRVPNQGIIINPMLSDETNICNGKPVDGLTTLRN 1025

Query: 512  G----------WERAGQCPPPPERKQSFLW 531
            G          W  +   PP P R+ + +W
Sbjct: 1026 GTLVAFRGHYFWMLSPFSPPSPARRITEVW 1055


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score = 44.7 bits (104), Expect = 8e-04
 Identities = 40/167 (23%), Positives = 61/167 (36%), Gaps = 25/167 (14%)

Query: 91  KRTKQTATKTKTLQGPAEKKPPSGSQAPRTKKQRVTKWQASEPAHSVNGEGGVLASAPDP 150
           K    T TK  +   P E  P +   AP T K         EPA +           P P
Sbjct: 411 KEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTK---------EPAPTTTKSAPTTPKEPSP 461

Query: 151 PVLRETAQNTQTGNQQEPSPNLSREKT----RENVPNSDSQPPPSCLTTAVPSPSKPR-- 204
              +E A  T     +EP+P   ++      +E  P +  +P P+  TT  P+P+ P+  
Sbjct: 462 TTTKEPAPTT----PKEPAPTTPKKPAPTTPKEPAPTTPKEPAPT--TTKKPAPTTPKEP 515

Query: 205 ----TAQLVLQRMQQFKRADPERLRHASEECSLEAAREENVPKDPQE 247
                 +      ++     PE+L   + E       EE  P  P+E
Sbjct: 516 APTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEE 562



 Score = 36.2 bits (82), Expect = 0.30
 Identities = 31/116 (26%), Positives = 46/116 (39%), Gaps = 15/116 (12%)

Query: 91  KRTKQTATKTKTLQGPAEKKPPSGSQAPRTKKQRVTKWQASEPAHSVNGEGGVLASAPDP 150
           K    T  K  T   P E  P +   AP T K+        +PA +   E       P P
Sbjct: 356 KEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPT-APKKPAPTTPKE-------PAP 407

Query: 151 PVLRETAQNTQTGNQQEPSPNLSRE---KTRENVPNSDSQPPPSCLTTAVPSPSKP 203
              +E A  T     +EPSP   +E    T ++ P +  +P P+   +A  +P +P
Sbjct: 408 TTPKEPAPTT----TKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEP 459



 Score = 35.4 bits (80), Expect = 0.51
 Identities = 143/784 (18%), Positives = 243/784 (30%), Gaps = 125/784 (15%)

Query: 996  EPSQITSEPEEQSGAVRERGLEVSHRLAPWQASPPHPCRFLLGPPQGGSPRGSHHTSGS- 1054
            EP+  T  P+E +    +     + + AP   +P  P       P   +P+    T+   
Sbjct: 310  EPAPTT--PKEPAPTTTKEPAPTTTKSAP--TTPKEPAPTTPKKPAPTTPKEPAPTTPKE 365

Query: 1055 -SLSTPRSRGGTSQVGSPTLLSPAVPSKQKRDRSILTLSKEPGHQKGKERRSVLECRNKG 1113
             + +TP+    T++  +PT      P+  K+     T  KEP     KE           
Sbjct: 366  PTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAP--TTPKEPAPTTPKEPAPTTT----- 418

Query: 1114 VLMFPEKSPSIDLTQSNPDHSSSRSQKSSSKLNEEDEVILLLDSDEELELEQTKMKSISS 1173
                 E SP+   T   P  ++++S  +++K                 E   T  KS  +
Sbjct: 419  ----KEPSPT---TPKEPAPTTTKSAPTTTK-----------------EPAPTTTKSAPT 454

Query: 1174 DPLEEKKALEISPRSCELFSIIDVDADQEPSQSPPRSEAVLQQEDEGALPENRGSLGRRG 1233
             P E        P              +EP+ + P+  A    ++         +     
Sbjct: 455  TPKEPSPTTTKEPAPT---------TPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK 505

Query: 1234 APWLFCDRE---SSPSEASTTDTSWLVPATPLASRSRDCSSQTQISSLRSGLAVQAVTQH 1290
             P     +E   ++P E + T    L P TP   +    + +    +    LA     + 
Sbjct: 506  KPAPTTPKEPAPTTPKETAPTTPKKLTPTTP--EKLAPTTPEKPAPTTPEELAPTTPEEP 563

Query: 1291 TPRASVGNREGNEVAQKFSVIRPQTPPPQTPSSCL--TPVSPGTSDGRRQGHRSPSRPHP 1348
            TP                    P+ P P TP +    TP  P  +  +     +P  P P
Sbjct: 564  TPTT------------------PEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAP 605

Query: 1349 GGHPHSSPLAPHPISGDRAHFSRRFLKHSP--PGPSFLNQTPAGEVVEVGDSDDEQEVAS 1406
                 ++P  P    G      +     +P  P P  L  T   E               
Sbjct: 606  TTPKETAPTTP---KGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPK 662

Query: 1407 HQANRSP-------PLDSDPPIPIDDCCWHME------PLSPIPIDHWNLERTGPLSTSS 1453
              A  +P       P +  P  P       ++      P  P P +       GP ST+S
Sbjct: 663  GTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTS 722

Query: 1454 ------------PSRRMNEAADSRDCRSPGLLDTTPIRGS-CTTQRKLQEKSSGAGSLGN 1500
                        P+     A  +    +P   +T P   S  +T    +E ++   S   
Sbjct: 723  DKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDE 782

Query: 1501 SRPSFLNSALWDVWDGEEQRP--PETPPPAQMPSAGGAQKPEGLETPKGANRKKNLPPKV 1558
            S P           +   + P  P T  PA       A KPE   T K    +++L    
Sbjct: 783  STPELSAEPTPKALENSPKEPGVPTTKTPA-------ATKPEMTTTAKDKTTERDLRTTP 835

Query: 1559 PITPMPQYSIMETPVLKKELDRFGVRPLPKRQMVLKLKEIFQYTHQTLDSDS-EDESQSS 1617
              T        ET    ++     +     +      ++   +   TL + +   +  ++
Sbjct: 836  ETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTT 895

Query: 1618 QPLLQAPHCQTLASQTYKPSRAGVHAQQEATTGPGAHRP----KGPAKTKGPRHQRKHHE 1673
            +  +          +T KP     +++    T P   +P    K P  TK P+   +  +
Sbjct: 896  KKTITTTEIMNKPEETAKPKDRATNSK---ATTPKPQKPTKAPKKPTSTKKPKTMPRVRK 952

Query: 1674 SITPPSRSPTKEAPPGLNDDAQIPASQESVATSVDGSDSSLSSQSSSSCEFGAAFESAGE 1733
              T P+        P LN  ++I  +     T  +       + +S   E     E AG 
Sbjct: 953  PKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPN------QTPNSKLVEVNPKSEDAGG 1006

Query: 1734 EEGE 1737
             EGE
Sbjct: 1007 AEGE 1010



 Score = 35.0 bits (79), Expect = 0.67
 Identities = 96/510 (18%), Positives = 169/510 (33%), Gaps = 98/510 (19%)

Query: 93   TKQTATKTKTLQGPAE---KKPPSGSQAPRTKKQRVTKWQASEPAHSV-NGEGGVLASAP 148
            T    T   TL+ PA    KKP     AP T K+  T     +PA +   G        P
Sbjct: 614  TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKE-PTSTTCDKPAPTTPKGTAPTTPKEP 672

Query: 149  DPPVLRETAQNTQTGNQ----QEPSPNLSREKT-------------------------RE 179
             P   +E A  T  G      +EP+P   ++                           +E
Sbjct: 673  APTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKE 732

Query: 180  NVPNSDSQPPPSCLTTAVPSPSKPRTAQLVLQRMQ-QFKRADPERLRHASEECSLEAARE 238
              P +  +P P+  T   P+P+ P T       +       +P  +  + +E + E + E
Sbjct: 733  TAPTTPKEPAPT--TPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAE 790

Query: 239  ------ENVPKDPQEEMMAGNVYGLGPPAPESDAAVALTLQQEFARVGASAHDDSLEEKG 292
                  EN PK+P            G P  ++ AA           +  +A D + E   
Sbjct: 791  PTPKALENSPKEP------------GVPTTKTPAATK-------PEMTTTAKDKTTERD- 830

Query: 293  LFFCQICQKNLSAMNVTRREQHVNRCLDEAEKTLRPS-VPQIPECPICGKPFLTLKSRTS 351
                   +   +A  +T+          E++ T   + V              TLK+ T 
Sbjct: 831  --LRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTL 888

Query: 352  HLKQCAVKMEVGPQLLLQAVRLQTAQPEGSSSPPMFSFSDHSRGLKR-RGPTSKKEPRKR 410
              K    K  +    ++     +TA+P+  ++    +     +  K  + PTS K+P+  
Sbjct: 889  APKVTTTKKTITTTEIMNKPE-ETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTM 947

Query: 411  RKVDEAPSEDLLVAMALSRSEMEPGAAVPALRLESAFSERIRP----------------- 453
             +V +  +      M  +  E+ P + +    L++       P                 
Sbjct: 948  PRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPKSEDAGGA 1007

Query: 454  EAENKSRKKKPPVSPPLLLVQDSETTGRQIEDRVAL--LLSEEVELSSTPPLPASRILKE 511
            E E      +P V  P  +  D +   R     + +  +LS+E  + +  P+     L+ 
Sbjct: 1008 EGETPHMLLRPHVFMP-EVTPDMDYLPRVPNQGIIINPMLSDETNICNGKPVDGLTTLRN 1066

Query: 512  G----------WERAGQCPPPPERKQSFLW 531
            G          W  +   PP P R+ + +W
Sbjct: 1067 GTLVAFRGHYFWMLSPFSPPSPARRITEVW 1096


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score = 44.7 bits (104), Expect = 8e-04
 Identities = 40/167 (23%), Positives = 61/167 (36%), Gaps = 25/167 (14%)

Query: 91  KRTKQTATKTKTLQGPAEKKPPSGSQAPRTKKQRVTKWQASEPAHSVNGEGGVLASAPDP 150
           K    T TK  +   P E  P +   AP T K         EPA +           P P
Sbjct: 463 KEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTK---------EPAPTTTKSAPTTPKEPSP 513

Query: 151 PVLRETAQNTQTGNQQEPSPNLSREKT----RENVPNSDSQPPPSCLTTAVPSPSKPR-- 204
              +E A  T     +EP+P   ++      +E  P +  +P P+  TT  P+P+ P+  
Sbjct: 514 TTTKEPAPTT----PKEPAPTTPKKPAPTTPKEPAPTTPKEPAPT--TTKKPAPTTPKEP 567

Query: 205 ----TAQLVLQRMQQFKRADPERLRHASEECSLEAAREENVPKDPQE 247
                 +      ++     PE+L   + E       EE  P  P+E
Sbjct: 568 APTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEE 614



 Score = 36.2 bits (82), Expect = 0.30
 Identities = 31/116 (26%), Positives = 46/116 (39%), Gaps = 15/116 (12%)

Query: 91  KRTKQTATKTKTLQGPAEKKPPSGSQAPRTKKQRVTKWQASEPAHSVNGEGGVLASAPDP 150
           K    T  K  T   P E  P +   AP T K+        +PA +   E       P P
Sbjct: 408 KEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPT-APKKPAPTTPKE-------PAP 459

Query: 151 PVLRETAQNTQTGNQQEPSPNLSRE---KTRENVPNSDSQPPPSCLTTAVPSPSKP 203
              +E A  T     +EPSP   +E    T ++ P +  +P P+   +A  +P +P
Sbjct: 460 TTPKEPAPTT----TKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEP 511



 Score = 35.4 bits (80), Expect = 0.51
 Identities = 143/784 (18%), Positives = 243/784 (30%), Gaps = 125/784 (15%)

Query: 996  EPSQITSEPEEQSGAVRERGLEVSHRLAPWQASPPHPCRFLLGPPQGGSPRGSHHTSGS- 1054
            EP+  T  P+E +    +     + + AP   +P  P       P   +P+    T+   
Sbjct: 362  EPAPTT--PKEPAPTTTKEPAPTTTKSAP--TTPKEPAPTTPKKPAPTTPKEPAPTTPKE 417

Query: 1055 -SLSTPRSRGGTSQVGSPTLLSPAVPSKQKRDRSILTLSKEPGHQKGKERRSVLECRNKG 1113
             + +TP+    T++  +PT      P+  K+     T  KEP     KE           
Sbjct: 418  PTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAP--TTPKEPAPTTPKEPAPTTT----- 470

Query: 1114 VLMFPEKSPSIDLTQSNPDHSSSRSQKSSSKLNEEDEVILLLDSDEELELEQTKMKSISS 1173
                 E SP+   T   P  ++++S  +++K                 E   T  KS  +
Sbjct: 471  ----KEPSPT---TPKEPAPTTTKSAPTTTK-----------------EPAPTTTKSAPT 506

Query: 1174 DPLEEKKALEISPRSCELFSIIDVDADQEPSQSPPRSEAVLQQEDEGALPENRGSLGRRG 1233
             P E        P              +EP+ + P+  A    ++         +     
Sbjct: 507  TPKEPSPTTTKEPAPT---------TPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK 557

Query: 1234 APWLFCDRE---SSPSEASTTDTSWLVPATPLASRSRDCSSQTQISSLRSGLAVQAVTQH 1290
             P     +E   ++P E + T    L P TP   +    + +    +    LA     + 
Sbjct: 558  KPAPTTPKEPAPTTPKETAPTTPKKLTPTTP--EKLAPTTPEKPAPTTPEELAPTTPEEP 615

Query: 1291 TPRASVGNREGNEVAQKFSVIRPQTPPPQTPSSCL--TPVSPGTSDGRRQGHRSPSRPHP 1348
            TP                    P+ P P TP +    TP  P  +  +     +P  P P
Sbjct: 616  TPTT------------------PEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAP 657

Query: 1349 GGHPHSSPLAPHPISGDRAHFSRRFLKHSP--PGPSFLNQTPAGEVVEVGDSDDEQEVAS 1406
                 ++P  P    G      +     +P  P P  L  T   E               
Sbjct: 658  TTPKETAPTTP---KGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPK 714

Query: 1407 HQANRSP-------PLDSDPPIPIDDCCWHME------PLSPIPIDHWNLERTGPLSTSS 1453
              A  +P       P +  P  P       ++      P  P P +       GP ST+S
Sbjct: 715  GTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTS 774

Query: 1454 ------------PSRRMNEAADSRDCRSPGLLDTTPIRGS-CTTQRKLQEKSSGAGSLGN 1500
                        P+     A  +    +P   +T P   S  +T    +E ++   S   
Sbjct: 775  DKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDE 834

Query: 1501 SRPSFLNSALWDVWDGEEQRP--PETPPPAQMPSAGGAQKPEGLETPKGANRKKNLPPKV 1558
            S P           +   + P  P T  PA       A KPE   T K    +++L    
Sbjct: 835  STPELSAEPTPKALENSPKEPGVPTTKTPA-------ATKPEMTTTAKDKTTERDLRTTP 887

Query: 1559 PITPMPQYSIMETPVLKKELDRFGVRPLPKRQMVLKLKEIFQYTHQTLDSDS-EDESQSS 1617
              T        ET    ++     +     +      ++   +   TL + +   +  ++
Sbjct: 888  ETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTT 947

Query: 1618 QPLLQAPHCQTLASQTYKPSRAGVHAQQEATTGPGAHRP----KGPAKTKGPRHQRKHHE 1673
            +  +          +T KP     +++    T P   +P    K P  TK P+   +  +
Sbjct: 948  KKTITTTEIMNKPEETAKPKDRATNSK---ATTPKPQKPTKAPKKPTSTKKPKTMPRVRK 1004

Query: 1674 SITPPSRSPTKEAPPGLNDDAQIPASQESVATSVDGSDSSLSSQSSSSCEFGAAFESAGE 1733
              T P+        P LN  ++I  +     T  +       + +S   E     E AG 
Sbjct: 1005 PKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPN------QTPNSKLVEVNPKSEDAGG 1058

Query: 1734 EEGE 1737
             EGE
Sbjct: 1059 AEGE 1062



 Score = 35.0 bits (79), Expect = 0.67
 Identities = 96/510 (18%), Positives = 169/510 (33%), Gaps = 98/510 (19%)

Query: 93   TKQTATKTKTLQGPAE---KKPPSGSQAPRTKKQRVTKWQASEPAHSV-NGEGGVLASAP 148
            T    T   TL+ PA    KKP     AP T K+  T     +PA +   G        P
Sbjct: 666  TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKE-PTSTTCDKPAPTTPKGTAPTTPKEP 724

Query: 149  DPPVLRETAQNTQTGNQ----QEPSPNLSREKT-------------------------RE 179
             P   +E A  T  G      +EP+P   ++                           +E
Sbjct: 725  APTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKE 784

Query: 180  NVPNSDSQPPPSCLTTAVPSPSKPRTAQLVLQRMQ-QFKRADPERLRHASEECSLEAARE 238
              P +  +P P+  T   P+P+ P T       +       +P  +  + +E + E + E
Sbjct: 785  TAPTTPKEPAPT--TPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAE 842

Query: 239  ------ENVPKDPQEEMMAGNVYGLGPPAPESDAAVALTLQQEFARVGASAHDDSLEEKG 292
                  EN PK+P            G P  ++ AA           +  +A D + E   
Sbjct: 843  PTPKALENSPKEP------------GVPTTKTPAATK-------PEMTTTAKDKTTERD- 882

Query: 293  LFFCQICQKNLSAMNVTRREQHVNRCLDEAEKTLRPS-VPQIPECPICGKPFLTLKSRTS 351
                   +   +A  +T+          E++ T   + V              TLK+ T 
Sbjct: 883  --LRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTL 940

Query: 352  HLKQCAVKMEVGPQLLLQAVRLQTAQPEGSSSPPMFSFSDHSRGLKR-RGPTSKKEPRKR 410
              K    K  +    ++     +TA+P+  ++    +     +  K  + PTS K+P+  
Sbjct: 941  APKVTTTKKTITTTEIMNKPE-ETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTM 999

Query: 411  RKVDEAPSEDLLVAMALSRSEMEPGAAVPALRLESAFSERIRP----------------- 453
             +V +  +      M  +  E+ P + +    L++       P                 
Sbjct: 1000 PRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPKSEDAGGA 1059

Query: 454  EAENKSRKKKPPVSPPLLLVQDSETTGRQIEDRVAL--LLSEEVELSSTPPLPASRILKE 511
            E E      +P V  P  +  D +   R     + +  +LS+E  + +  P+     L+ 
Sbjct: 1060 EGETPHMLLRPHVFMP-EVTPDMDYLPRVPNQGIIINPMLSDETNICNGKPVDGLTTLRN 1118

Query: 512  G----------WERAGQCPPPPERKQSFLW 531
            G          W  +   PP P R+ + +W
Sbjct: 1119 GTLVAFRGHYFWMLSPFSPPSPARRITEVW 1148


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score = 44.7 bits (104), Expect = 8e-04
 Identities = 40/167 (23%), Positives = 61/167 (36%), Gaps = 25/167 (14%)

Query: 91  KRTKQTATKTKTLQGPAEKKPPSGSQAPRTKKQRVTKWQASEPAHSVNGEGGVLASAPDP 150
           K    T TK  +   P E  P +   AP T K         EPA +           P P
Sbjct: 504 KEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTK---------EPAPTTTKSAPTTPKEPSP 554

Query: 151 PVLRETAQNTQTGNQQEPSPNLSREKT----RENVPNSDSQPPPSCLTTAVPSPSKPR-- 204
              +E A  T     +EP+P   ++      +E  P +  +P P+  TT  P+P+ P+  
Sbjct: 555 TTTKEPAPTT----PKEPAPTTPKKPAPTTPKEPAPTTPKEPAPT--TTKKPAPTTPKEP 608

Query: 205 ----TAQLVLQRMQQFKRADPERLRHASEECSLEAAREENVPKDPQE 247
                 +      ++     PE+L   + E       EE  P  P+E
Sbjct: 609 APTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEE 655



 Score = 36.2 bits (82), Expect = 0.30
 Identities = 31/116 (26%), Positives = 46/116 (39%), Gaps = 15/116 (12%)

Query: 91  KRTKQTATKTKTLQGPAEKKPPSGSQAPRTKKQRVTKWQASEPAHSVNGEGGVLASAPDP 150
           K    T  K  T   P E  P +   AP T K+        +PA +   E       P P
Sbjct: 449 KEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPT-APKKPAPTTPKE-------PAP 500

Query: 151 PVLRETAQNTQTGNQQEPSPNLSRE---KTRENVPNSDSQPPPSCLTTAVPSPSKP 203
              +E A  T     +EPSP   +E    T ++ P +  +P P+   +A  +P +P
Sbjct: 501 TTPKEPAPTT----TKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEP 552



 Score = 35.4 bits (80), Expect = 0.51
 Identities = 143/784 (18%), Positives = 243/784 (30%), Gaps = 125/784 (15%)

Query: 996  EPSQITSEPEEQSGAVRERGLEVSHRLAPWQASPPHPCRFLLGPPQGGSPRGSHHTSGS- 1054
            EP+  T  P+E +    +     + + AP   +P  P       P   +P+    T+   
Sbjct: 403  EPAPTT--PKEPAPTTTKEPAPTTTKSAP--TTPKEPAPTTPKKPAPTTPKEPAPTTPKE 458

Query: 1055 -SLSTPRSRGGTSQVGSPTLLSPAVPSKQKRDRSILTLSKEPGHQKGKERRSVLECRNKG 1113
             + +TP+    T++  +PT      P+  K+     T  KEP     KE           
Sbjct: 459  PTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAP--TTPKEPAPTTPKEPAPTTT----- 511

Query: 1114 VLMFPEKSPSIDLTQSNPDHSSSRSQKSSSKLNEEDEVILLLDSDEELELEQTKMKSISS 1173
                 E SP+   T   P  ++++S  +++K                 E   T  KS  +
Sbjct: 512  ----KEPSPT---TPKEPAPTTTKSAPTTTK-----------------EPAPTTTKSAPT 547

Query: 1174 DPLEEKKALEISPRSCELFSIIDVDADQEPSQSPPRSEAVLQQEDEGALPENRGSLGRRG 1233
             P E        P              +EP+ + P+  A    ++         +     
Sbjct: 548  TPKEPSPTTTKEPAPT---------TPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK 598

Query: 1234 APWLFCDRE---SSPSEASTTDTSWLVPATPLASRSRDCSSQTQISSLRSGLAVQAVTQH 1290
             P     +E   ++P E + T    L P TP   +    + +    +    LA     + 
Sbjct: 599  KPAPTTPKEPAPTTPKETAPTTPKKLTPTTP--EKLAPTTPEKPAPTTPEELAPTTPEEP 656

Query: 1291 TPRASVGNREGNEVAQKFSVIRPQTPPPQTPSSCL--TPVSPGTSDGRRQGHRSPSRPHP 1348
            TP                    P+ P P TP +    TP  P  +  +     +P  P P
Sbjct: 657  TPTT------------------PEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAP 698

Query: 1349 GGHPHSSPLAPHPISGDRAHFSRRFLKHSP--PGPSFLNQTPAGEVVEVGDSDDEQEVAS 1406
                 ++P  P    G      +     +P  P P  L  T   E               
Sbjct: 699  TTPKETAPTTP---KGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPK 755

Query: 1407 HQANRSP-------PLDSDPPIPIDDCCWHME------PLSPIPIDHWNLERTGPLSTSS 1453
              A  +P       P +  P  P       ++      P  P P +       GP ST+S
Sbjct: 756  GTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTS 815

Query: 1454 ------------PSRRMNEAADSRDCRSPGLLDTTPIRGS-CTTQRKLQEKSSGAGSLGN 1500
                        P+     A  +    +P   +T P   S  +T    +E ++   S   
Sbjct: 816  DKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDE 875

Query: 1501 SRPSFLNSALWDVWDGEEQRP--PETPPPAQMPSAGGAQKPEGLETPKGANRKKNLPPKV 1558
            S P           +   + P  P T  PA       A KPE   T K    +++L    
Sbjct: 876  STPELSAEPTPKALENSPKEPGVPTTKTPA-------ATKPEMTTTAKDKTTERDLRTTP 928

Query: 1559 PITPMPQYSIMETPVLKKELDRFGVRPLPKRQMVLKLKEIFQYTHQTLDSDS-EDESQSS 1617
              T        ET    ++     +     +      ++   +   TL + +   +  ++
Sbjct: 929  ETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTT 988

Query: 1618 QPLLQAPHCQTLASQTYKPSRAGVHAQQEATTGPGAHRP----KGPAKTKGPRHQRKHHE 1673
            +  +          +T KP     +++    T P   +P    K P  TK P+   +  +
Sbjct: 989  KKTITTTEIMNKPEETAKPKDRATNSK---ATTPKPQKPTKAPKKPTSTKKPKTMPRVRK 1045

Query: 1674 SITPPSRSPTKEAPPGLNDDAQIPASQESVATSVDGSDSSLSSQSSSSCEFGAAFESAGE 1733
              T P+        P LN  ++I  +     T  +       + +S   E     E AG 
Sbjct: 1046 PKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPN------QTPNSKLVEVNPKSEDAGG 1099

Query: 1734 EEGE 1737
             EGE
Sbjct: 1100 AEGE 1103



 Score = 35.0 bits (79), Expect = 0.67
 Identities = 96/510 (18%), Positives = 169/510 (33%), Gaps = 98/510 (19%)

Query: 93   TKQTATKTKTLQGPAE---KKPPSGSQAPRTKKQRVTKWQASEPAHSV-NGEGGVLASAP 148
            T    T   TL+ PA    KKP     AP T K+  T     +PA +   G        P
Sbjct: 707  TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKE-PTSTTCDKPAPTTPKGTAPTTPKEP 765

Query: 149  DPPVLRETAQNTQTGNQ----QEPSPNLSREKT-------------------------RE 179
             P   +E A  T  G      +EP+P   ++                           +E
Sbjct: 766  APTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKE 825

Query: 180  NVPNSDSQPPPSCLTTAVPSPSKPRTAQLVLQRMQ-QFKRADPERLRHASEECSLEAARE 238
              P +  +P P+  T   P+P+ P T       +       +P  +  + +E + E + E
Sbjct: 826  TAPTTPKEPAPT--TPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAE 883

Query: 239  ------ENVPKDPQEEMMAGNVYGLGPPAPESDAAVALTLQQEFARVGASAHDDSLEEKG 292
                  EN PK+P            G P  ++ AA           +  +A D + E   
Sbjct: 884  PTPKALENSPKEP------------GVPTTKTPAATK-------PEMTTTAKDKTTERD- 923

Query: 293  LFFCQICQKNLSAMNVTRREQHVNRCLDEAEKTLRPS-VPQIPECPICGKPFLTLKSRTS 351
                   +   +A  +T+          E++ T   + V              TLK+ T 
Sbjct: 924  --LRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTL 981

Query: 352  HLKQCAVKMEVGPQLLLQAVRLQTAQPEGSSSPPMFSFSDHSRGLKR-RGPTSKKEPRKR 410
              K    K  +    ++     +TA+P+  ++    +     +  K  + PTS K+P+  
Sbjct: 982  APKVTTTKKTITTTEIMNKPE-ETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTM 1040

Query: 411  RKVDEAPSEDLLVAMALSRSEMEPGAAVPALRLESAFSERIRP----------------- 453
             +V +  +      M  +  E+ P + +    L++       P                 
Sbjct: 1041 PRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPKSEDAGGA 1100

Query: 454  EAENKSRKKKPPVSPPLLLVQDSETTGRQIEDRVAL--LLSEEVELSSTPPLPASRILKE 511
            E E      +P V  P  +  D +   R     + +  +LS+E  + +  P+     L+ 
Sbjct: 1101 EGETPHMLLRPHVFMP-EVTPDMDYLPRVPNQGIIINPMLSDETNICNGKPVDGLTTLRN 1159

Query: 512  G----------WERAGQCPPPPERKQSFLW 531
            G          W  +   PP P R+ + +W
Sbjct: 1160 GTLVAFRGHYFWMLSPFSPPSPARRITEVW 1189


>gi|95147555 microtubule-associated protein 1A [Homo sapiens]
          Length = 2803

 Score = 44.3 bits (103), Expect = 0.001
 Identities = 29/68 (42%), Positives = 32/68 (47%), Gaps = 3/68 (4%)

Query: 545  FYTARLVPPLVPQRPAQGLMQEP--VPPLVPPEHSELSERRSPALHGT-PTAGCGSRGPS 601
            F  A L  P VP RP  G   EP   PP VPP    LS+  SP L+G   +     R PS
Sbjct: 2033 FSYAALAGPTVPPRPEPGPSMEPSLTPPAVPPRAPILSKGPSPPLNGNILSCSPDRRSPS 2092

Query: 602  PSASQREH 609
            P  S R H
Sbjct: 2093 PKESGRSH 2100



 Score = 32.3 bits (72), Expect = 4.4
 Identities = 28/97 (28%), Positives = 41/97 (42%), Gaps = 5/97 (5%)

Query: 793 TDSEGKPWEEK---EAENCESRAENFQELLRSMWADEEEEAETLLKSKDHEEDQENVNEA 849
           T+ E   WEEK   EAE    R E  +E    +  D  E+AE     + H  D+E  +  
Sbjct: 616 TEEEKDTWEEKKQREAERLPDRTEAREESEPEVKEDVIEKAELEEMEEVHPSDEEEEDAT 675

Query: 850 EMEEIYE-FAATQRKLLQEERAAGAGEDADWLEGGSP 885
           + E  Y+       K+    R A  G +   L+G +P
Sbjct: 676 KAEGFYQKHMQEPLKVTPRSREAFGGRELG-LQGKAP 711



 Score = 32.3 bits (72), Expect = 4.4
 Identities = 42/164 (25%), Positives = 66/164 (40%), Gaps = 23/164 (14%)

Query: 112  PSGSQAPRTKKQRVTKWQASEPAHSVNGEGG-VLASAPDPPVLRETAQNTQTGNQQEPSP 170
            P+  Q P   + R      S P  S+   G   LA AP PP        T+     E + 
Sbjct: 2175 PAPPQLPSPAEPR------SAPCGSLAFSGDRALALAPGPPT------RTRHDEYLEVTK 2222

Query: 171  NLSREKTRENVPNSDSQPPPSCLTTAVPSPSKPRTAQLVLQRMQQFKRADPERLRHASEE 230
              S + +   +P+  S   P  L + +P P+ P  ++           A    +   +E 
Sbjct: 2223 APSLDSSLPQLPSPSSPGAP--LLSNLPRPASPALSE------GSSSEATTPVISSVAER 2274

Query: 231  CS--LEAAREENVPKDPQEEMMAGNVYGLGPPAPESDAAVALTL 272
             S  LEAA +E+   DP  E  A +++ L P +P   A++ L L
Sbjct: 2275 FSPSLEAAEQESGELDPGMEPAAHSLWDLTPLSPAPPASLDLAL 2318



 Score = 31.2 bits (69), Expect = 9.7
 Identities = 29/144 (20%), Positives = 66/144 (45%), Gaps = 17/144 (11%)

Query: 1101 KERRSVLECRNKGVLMFPEKSPSIDLTQSNPDHSSSRSQKSSSKLNEEDEVILLLDSDEE 1160
            +++   LE ++K +    EK  +++     P+      ++  + L ++D+   L   D++
Sbjct: 1423 EQKDKALEPKDKDL---EEKDKALEQKDKIPEEKDKALEQKDTALEQKDKA--LEPKDKD 1477

Query: 1161 LELEQTKMKSISSDPLEEKKALEISPRSCELFSIIDVDAD------QEPSQSPPRSEAVL 1214
            LE +   ++     P E+ KAL+   RS E  +  D  A+      ++  ++P +     
Sbjct: 1478 LEQKDRVLEQKEKIPEEKDKALDQKVRSVEHKAPEDTVAEMKDRDLEQTDKAPEQKHQAQ 1537

Query: 1215 QQED------EGALPENRGSLGRR 1232
            +Q+D      + AL +   +LG++
Sbjct: 1538 EQKDKVSEKKDQALEQKYWALGQK 1561


>gi|19924097 synapsin I isoform Ib [Homo sapiens]
          Length = 669

 Score = 44.3 bits (103), Expect = 0.001
 Identities = 61/246 (24%), Positives = 75/246 (30%), Gaps = 48/246 (19%)

Query: 1314 QTPPPQTPSSCLTPVSPGTSDGRRQGHRSPSRPHPGGHPHSSPLAPHPISGDRAHFSRRF 1373
            Q PPPQ       P  PG    +RQG     RP P G  H S L P   S          
Sbjct: 459  QRPPPQGG-----PPQPGPGP-QRQGPPLQQRPPPQGQQHLSGLGPPAGSP--------- 503

Query: 1374 LKHSPPGPSFLNQTPAGEVVEVGDSDDEQE-----------VASHQANRSPPLDSDPPIP 1422
            L    P P+   Q PA +          Q             A   A+ SP   + PP  
Sbjct: 504  LPQRLPSPTSAPQQPASQAAPPTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGPP-- 561

Query: 1423 IDDCCWHMEPLSPIPIDHWNLERTGPLSTSSPSRRMNEAADSRDCRSPGLLDTTPIRGSC 1482
                        P P         G      P +    A  +R     G     P  G  
Sbjct: 562  --QATRQTSVSGPAPPKASGAPPGGQQRQGPPQKPPGPAGPTRQASQAG---PVPRTGPP 616

Query: 1483 TTQRKLQEKSSGAGSLGNSRPSFLNSALWDVWDGEEQRPPETPPPAQMPSAGGAQKPEGL 1542
            TTQ   Q + SG G  G  +P               Q+P +  PP    +AGG   P+  
Sbjct: 617  TTQ---QPRPSGPGPAGRPKPQL------------AQKPSQDVPPPATAAAGGPPHPQLK 661

Query: 1543 ETPKGA 1548
             +P  A
Sbjct: 662  ASPAQA 667



 Score = 37.4 bits (85), Expect = 0.14
 Identities = 20/63 (31%), Positives = 28/63 (44%)

Query: 1650 GPGAHRPKGPAKTKGPRHQRKHHESITPPSRSPTKEAPPGLNDDAQIPASQESVATSVDG 1709
            GPG  R   P + + P   ++H   + PP+ SP  +  P      Q PASQ +  T   G
Sbjct: 471  GPGPQRQGPPLQQRPPPQGQQHLSGLGPPAGSPLPQRLPSPTSAPQQPASQAAPPTQGQG 530

Query: 1710 SDS 1712
              S
Sbjct: 531  RQS 533



 Score = 36.6 bits (83), Expect = 0.23
 Identities = 44/191 (23%), Positives = 68/191 (35%), Gaps = 17/191 (8%)

Query: 1371 RRFLKHSPPGPSFLNQTPAGEVVEVGDSDDEQEVASHQANRSPPLDSDPPIPIDDCCWHM 1430
            R+  + + PG     QTP+   + +G    +Q  A   A + PP    PP P        
Sbjct: 420  RQRQRDASPGRGSHGQTPSPGALPLGRQTSQQP-AGPPAQQRPPPQGGPPQPGPGPQRQG 478

Query: 1431 EPLS--PIPIDHWNLERTGPLSTSSPSRRMNEAADSRDCRSPGLLDTTPIRGSCTTQRKL 1488
             PL   P P    +L   GP + S   +R+     +   + P      P +G     R +
Sbjct: 479  PPLQQRPPPQGQQHLSGLGPPAGSPLPQRLPSPTSAP--QQPASQAAPPTQGQGRQSRPV 536

Query: 1489 QEKSSGAGSLGNSRPSFLNSALWDVWDGEEQRPPETPPPAQMPSAGGAQKPEGLETPKGA 1548
               + G G+   +RP    S          QR    P   +  S  G   P+    P G 
Sbjct: 537  ---AGGPGAPPAARPPASPSP---------QRQAGPPQATRQTSVSGPAPPKASGAPPGG 584

Query: 1549 NRKKNLPPKVP 1559
             +++  P K P
Sbjct: 585  QQRQGPPQKPP 595



 Score = 32.0 bits (71), Expect = 5.7
 Identities = 32/115 (27%), Positives = 40/115 (34%), Gaps = 13/115 (11%)

Query: 97  ATKTKTLQGPAEKKPPSGSQAPRTKKQRVTKWQASEPAHSVNGEGGVLASAPDP-PVLRE 155
           AT+  ++ GPA   PP  S AP   +QR        P     G  G    A    PV R 
Sbjct: 563 ATRQTSVSGPA---PPKASGAPPGGQQR------QGPPQKPPGPAGPTRQASQAGPVPRT 613

Query: 156 TAQNTQTGNQQEPSPNLSREKTRENVPNSDSQPPPSCLTTAVPSP---SKPRTAQ 207
               TQ      P P    +      P+ D  PP +      P P   + P  AQ
Sbjct: 614 GPPTTQQPRPSGPGPAGRPKPQLAQKPSQDVPPPATAAAGGPPHPQLKASPAQAQ 668


>gi|92091572 dedicator of cytokinesis 4 [Homo sapiens]
          Length = 1966

 Score = 43.9 bits (102), Expect = 0.001
 Identities = 76/332 (22%), Positives = 123/332 (37%), Gaps = 39/332 (11%)

Query: 1241 RESSPSEASTTDTSWLVPATPLASRSRDCSSQTQISSLRSGLAVQAVTQHTPRASVGNRE 1300
            R S+P+  S   T  +   +PL+  + +  S + +SS  S        Q      V N +
Sbjct: 1612 RNSAPASVSPDGTRVIPRRSPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQ 1671

Query: 1301 GNEVAQKFSVIRPQTPPPQTPSSCLTPVSPGTSDGRRQGHRSPSRPHPGGHPHSSPLAPH 1360
             +      S     +P   + +      SP  SD + +  R  S   P   P  S + P 
Sbjct: 1672 PSPSTSSLSSTHSASPNVTSSAPSSARASPLLSD-KHKHSRENSCLSPRERP-CSAIYPT 1729

Query: 1361 PISGDRA----HFSRRFLKHSPPGPS----FLNQTPAGEVVEVGDSDDEQEVASHQANRS 1412
            P+   +     H     L  S P  S     +N TP+   ++ G   + + ++      S
Sbjct: 1730 PVEPSQRMLFNHIGDGALPRSDPNLSAPEKAVNPTPSSWSLDSG--KEAKNMSDSGKLIS 1787

Query: 1413 PPLDSDPPIPIDDC--CWHMEPLSPIPIDHWNLERTGPLSTSSPSRRMNEAADSRDCRSP 1470
            PP+   PP P        H   +SP P     L+ +    T SP           +  SP
Sbjct: 1788 PPV---PPRPTQTASPARHTTSVSPSPAGRSPLKGSVQSFTPSPV----------EYHSP 1834

Query: 1471 GLLDTTPIRGSCTTQRKLQEKSSGAGSLGNSRPSFLNSALWDVWDGEEQRPPETPPPAQM 1530
            GL+  +P+             SSG  SL  SR S   ++ ++    E+  P   P P  +
Sbjct: 1835 GLISNSPVLSG--------SYSSGISSL--SRCSTSETSGFENQVNEQSAPLPVPVPVPV 1884

Query: 1531 PSAGGAQ--KPEGLETPKGANRKKNLPPKVPI 1560
            PS GG +  + E    P  +  ++ L   VP+
Sbjct: 1885 PSYGGEEPVRKESKTPPPYSVYERTLRRPVPL 1916


>gi|4507161 SRY-box 11 [Homo sapiens]
          Length = 441

 Score = 43.9 bits (102), Expect = 0.001
 Identities = 44/163 (26%), Positives = 63/163 (38%), Gaps = 22/163 (13%)

Query: 1607 DSDSEDESQSSQPLLQAPHCQTLASQTYK-------PSRAGVHAQQEATTGPGAHRPKGP 1659
            + D EDE    Q LLQ P  Q   SQ  +       P+   + +  E+  G   +     
Sbjct: 242  EPDEEDEEPPHQQLLQPPGQQP--SQLLRRYNVAKVPASPTLSSSAESPEGASLYDEVRA 299

Query: 1660 AKTKGPRHQRKHHESITPPSRSPTKEAPPGLNDDAQIPASQESVATSVDGSDSSLSSQSS 1719
              T G     + + S     ++ TK+ PP L   A  PAS  SV+TS   S  S S  S 
Sbjct: 300  GATSGAGGGSRLYYSF----KNITKQHPPPLAQPALSPASSRSVSTSSSSSSGSSSGSSG 355

Query: 1720 S---------SCEFGAAFESAGEEEGEGEVSASQAAVQAADTD 1753
                      S  F  +  SA E++  G  +A   ++   D D
Sbjct: 356  EDADDLMFDLSLNFSQSAHSASEQQLGGGAAAGNLSLSLVDKD 398


>gi|239743602 PREDICTED: hypothetical protein XP_002342903 [Homo
            sapiens]
          Length = 675

 Score = 43.5 bits (101), Expect = 0.002
 Identities = 112/495 (22%), Positives = 175/495 (35%), Gaps = 75/495 (15%)

Query: 850  EMEEIYEFAATQ--RKLLQEERAAGAGEDADWLEGGSPVSGQLLAGVQVQKQWDKVEEME 907
            E +++ E AA +  R L  E+  AGA E +  L   +P              W +    E
Sbjct: 16   EAKKVAEEAALEASRHLGGEQSQAGAPEGSKMLRATAPC-------------WFRPGYPE 62

Query: 908  PLEPGRDEAATTWEKMGQCALPPPQGQHSGARGAEAPEQEAPEEALGHSSCSSPSRDCQA 967
              +  ++ A      +G    P    + S    A AP    P    G+      + +   
Sbjct: 63   AKKVAKEAAPEASRHLGAEQSPAGAPEGSKMLRATAPCWFPP----GYPEAKKVAEEAAL 118

Query: 968  ERKEGSLPHSDDAGDYEQLFSSTQGEISEPSQITSEPEEQSGAVRERGLEVSHRLAPWQA 1027
            E  E  LP    A  +         + S    I +EP+ +  AV             W  
Sbjct: 119  EAPEFPLPSHQPAQSFGLWVPQMHKQASAFVDIQAEPQNRGPAVPPA----------WPK 168

Query: 1028 SPPHPCRFLLGPPQGGS-------PRGSHHTSGSSLSTPRSRGGTSQVGSPTLLSPAVPS 1080
                 C F   P Q GS       PR +   SG  +S PR R   +   SP L++    +
Sbjct: 169  MVTESCYF---PAQRGSACRLPAAPRLTERPSGVRISAPRKRKTIAHSSSPCLVTGYTDA 225

Query: 1081 KQKRDRSILTLSK--EPGHQKGKER-RSVLECRNKGVLMFPEKSPSIDLTQSNPDHSSSR 1137
            K+ R  S    S+  + G Q GK R RS + C+          S  I    S P  S  +
Sbjct: 226  KRTRVASSSQRSRGSKVGRQPGKTRNRSGMACKTTAT----TSSKRIVRRASLPSLSLKK 281

Query: 1138 SQKSSSKLNEEDEVI----LLLDSDEELELEQTKMKSISSDPLEEKKALEISPRSCELFS 1193
                 S   +   V+    L L ++E L+   +K ++      EEK A + SP      +
Sbjct: 282  PIILRSSGCQVPTVLRRGYLQLFTEECLKFCASKQEAEEKALNEEKVAYDCSPNKNRYLN 341

Query: 1194 IIDVDADQ----EPSQSPPRSEAVLQQE------DEGALPENRGSL---GRRGAPWLFCD 1240
            ++     +     PS  P  S A L          +  L EN        R G   LF  
Sbjct: 342  VVLNTLKRLKGLTPSSMPGLSRAALYSRLQEFLLTQDQLKENGYPFPHPERPGGAVLFTG 401

Query: 1241 RESSPSEAS-----TTDTSWLVPATPLASRSRDCS---SQTQISSLRSGLAVQAVTQHTP 1292
            +   P ++S        T +LV ++    R + C     + + S +  G     V+Q+T 
Sbjct: 402  QGKGPGDSSCRVCCRCGTEYLVSSSGRCVRDQLCYYHWGRVRSSQVAGG----RVSQYTC 457

Query: 1293 RASVGNREGNEVAQK 1307
             A+     G +VA++
Sbjct: 458  CAAAPGSVGCQVAKQ 472


>gi|239743600 PREDICTED: hypothetical protein XP_002342902 [Homo
            sapiens]
          Length = 675

 Score = 43.5 bits (101), Expect = 0.002
 Identities = 112/495 (22%), Positives = 175/495 (35%), Gaps = 75/495 (15%)

Query: 850  EMEEIYEFAATQ--RKLLQEERAAGAGEDADWLEGGSPVSGQLLAGVQVQKQWDKVEEME 907
            E +++ E AA +  R L  E+  AGA E +  L   +P              W +    E
Sbjct: 16   EAKKVAEEAALEASRHLGGEQSQAGAPEGSKMLRATAPC-------------WFRPGYPE 62

Query: 908  PLEPGRDEAATTWEKMGQCALPPPQGQHSGARGAEAPEQEAPEEALGHSSCSSPSRDCQA 967
              +  ++ A      +G    P    + S    A AP    P    G+      + +   
Sbjct: 63   AKKVAKEAAPEASRHLGAEQSPAGAPEGSKMLRATAPCWFPP----GYPEAKKVAEEAAL 118

Query: 968  ERKEGSLPHSDDAGDYEQLFSSTQGEISEPSQITSEPEEQSGAVRERGLEVSHRLAPWQA 1027
            E  E  LP    A  +         + S    I +EP+ +  AV             W  
Sbjct: 119  EAPEFPLPSHQPAQSFGLWVPQMHKQASAFVDIQAEPQNRGPAVPPA----------WPK 168

Query: 1028 SPPHPCRFLLGPPQGGS-------PRGSHHTSGSSLSTPRSRGGTSQVGSPTLLSPAVPS 1080
                 C F   P Q GS       PR +   SG  +S PR R   +   SP L++    +
Sbjct: 169  MVTESCYF---PAQRGSACRLPAAPRLTERPSGVRISAPRKRKTIAHSSSPCLVTGYTDA 225

Query: 1081 KQKRDRSILTLSK--EPGHQKGKER-RSVLECRNKGVLMFPEKSPSIDLTQSNPDHSSSR 1137
            K+ R  S    S+  + G Q GK R RS + C+          S  I    S P  S  +
Sbjct: 226  KRTRVASSSQRSRGSKVGRQPGKTRNRSGMACKTTAT----TSSKRIVRRASLPSLSLKK 281

Query: 1138 SQKSSSKLNEEDEVI----LLLDSDEELELEQTKMKSISSDPLEEKKALEISPRSCELFS 1193
                 S   +   V+    L L ++E L+   +K ++      EEK A + SP      +
Sbjct: 282  PIILRSSGCQVPTVLRRGYLQLFTEECLKFCASKQEAEEKALNEEKVAYDCSPNKNRYLN 341

Query: 1194 IIDVDADQ----EPSQSPPRSEAVLQQE------DEGALPENRGSL---GRRGAPWLFCD 1240
            ++     +     PS  P  S A L          +  L EN        R G   LF  
Sbjct: 342  VVLNTLKRLKGLTPSSMPGLSRAALYSRLQEFLLTQDQLKENGYPFPHPERPGGAVLFTG 401

Query: 1241 RESSPSEAS-----TTDTSWLVPATPLASRSRDCS---SQTQISSLRSGLAVQAVTQHTP 1292
            +   P ++S        T +LV ++    R + C     + + S +  G     V+Q+T 
Sbjct: 402  QGKGPGDSSCRVCCRCGTEYLVSSSGRCVRDQLCYYHWGRVRSSQVAGG----RVSQYTC 457

Query: 1293 RASVGNREGNEVAQK 1307
             A+     G +VA++
Sbjct: 458  CAAAPGSVGCQVAKQ 472


>gi|239743598 PREDICTED: hypothetical protein XP_002342901 [Homo
            sapiens]
          Length = 675

 Score = 43.5 bits (101), Expect = 0.002
 Identities = 112/495 (22%), Positives = 175/495 (35%), Gaps = 75/495 (15%)

Query: 850  EMEEIYEFAATQ--RKLLQEERAAGAGEDADWLEGGSPVSGQLLAGVQVQKQWDKVEEME 907
            E +++ E AA +  R L  E+  AGA E +  L   +P              W +    E
Sbjct: 16   EAKKVAEEAALEASRHLGGEQSQAGAPEGSKMLRATAPC-------------WFRPGYPE 62

Query: 908  PLEPGRDEAATTWEKMGQCALPPPQGQHSGARGAEAPEQEAPEEALGHSSCSSPSRDCQA 967
              +  ++ A      +G    P    + S    A AP    P    G+      + +   
Sbjct: 63   AKKVAKEAAPEASRHLGAEQSPAGAPEGSKMLRATAPCWFPP----GYPEAKKVAEEAAL 118

Query: 968  ERKEGSLPHSDDAGDYEQLFSSTQGEISEPSQITSEPEEQSGAVRERGLEVSHRLAPWQA 1027
            E  E  LP    A  +         + S    I +EP+ +  AV             W  
Sbjct: 119  EAPEFPLPSHQPAQSFGLWVPQMHKQASAFVDIQAEPQNRGPAVPPA----------WPK 168

Query: 1028 SPPHPCRFLLGPPQGGS-------PRGSHHTSGSSLSTPRSRGGTSQVGSPTLLSPAVPS 1080
                 C F   P Q GS       PR +   SG  +S PR R   +   SP L++    +
Sbjct: 169  MVTESCYF---PAQRGSACRLPAAPRLTERPSGVRISAPRKRKTIAHSSSPCLVTGYTDA 225

Query: 1081 KQKRDRSILTLSK--EPGHQKGKER-RSVLECRNKGVLMFPEKSPSIDLTQSNPDHSSSR 1137
            K+ R  S    S+  + G Q GK R RS + C+          S  I    S P  S  +
Sbjct: 226  KRTRVASSSQRSRGSKVGRQPGKTRNRSGMACKTTAT----TSSKRIVRRASLPSLSLKK 281

Query: 1138 SQKSSSKLNEEDEVI----LLLDSDEELELEQTKMKSISSDPLEEKKALEISPRSCELFS 1193
                 S   +   V+    L L ++E L+   +K ++      EEK A + SP      +
Sbjct: 282  PIILRSSGCQVPTVLRRGYLQLFTEECLKFCASKQEAEEKALNEEKVAYDCSPNKNRYLN 341

Query: 1194 IIDVDADQ----EPSQSPPRSEAVLQQE------DEGALPENRGSL---GRRGAPWLFCD 1240
            ++     +     PS  P  S A L          +  L EN        R G   LF  
Sbjct: 342  VVLNTLKRLKGLTPSSMPGLSRAALYSRLQEFLLTQDQLKENGYPFPHPERPGGAVLFTG 401

Query: 1241 RESSPSEAS-----TTDTSWLVPATPLASRSRDCS---SQTQISSLRSGLAVQAVTQHTP 1292
            +   P ++S        T +LV ++    R + C     + + S +  G     V+Q+T 
Sbjct: 402  QGKGPGDSSCRVCCRCGTEYLVSSSGRCVRDQLCYYHWGRVRSSQVAGG----RVSQYTC 457

Query: 1293 RASVGNREGNEVAQK 1307
             A+     G +VA++
Sbjct: 458  CAAAPGSVGCQVAKQ 472


>gi|239743596 PREDICTED: hypothetical protein XP_002342900 [Homo
            sapiens]
          Length = 675

 Score = 43.5 bits (101), Expect = 0.002
 Identities = 112/495 (22%), Positives = 175/495 (35%), Gaps = 75/495 (15%)

Query: 850  EMEEIYEFAATQ--RKLLQEERAAGAGEDADWLEGGSPVSGQLLAGVQVQKQWDKVEEME 907
            E +++ E AA +  R L  E+  AGA E +  L   +P              W +    E
Sbjct: 16   EAKKVAEEAALEASRHLGGEQSQAGAPEGSKMLRATAPC-------------WFRPGYPE 62

Query: 908  PLEPGRDEAATTWEKMGQCALPPPQGQHSGARGAEAPEQEAPEEALGHSSCSSPSRDCQA 967
              +  ++ A      +G    P    + S    A AP    P    G+      + +   
Sbjct: 63   AKKVAKEAAPEASRHLGAEQSPAGAPEGSKMLRATAPCWFPP----GYPEAKKVAEEAAL 118

Query: 968  ERKEGSLPHSDDAGDYEQLFSSTQGEISEPSQITSEPEEQSGAVRERGLEVSHRLAPWQA 1027
            E  E  LP    A  +         + S    I +EP+ +  AV             W  
Sbjct: 119  EAPEFPLPSHQPAQSFGLWVPQMHKQASAFVDIQAEPQNRGPAVPPA----------WPK 168

Query: 1028 SPPHPCRFLLGPPQGGS-------PRGSHHTSGSSLSTPRSRGGTSQVGSPTLLSPAVPS 1080
                 C F   P Q GS       PR +   SG  +S PR R   +   SP L++    +
Sbjct: 169  MVTESCYF---PAQRGSACRLPAAPRLTERPSGVRISAPRKRKTIAHSSSPCLVTGYTDA 225

Query: 1081 KQKRDRSILTLSK--EPGHQKGKER-RSVLECRNKGVLMFPEKSPSIDLTQSNPDHSSSR 1137
            K+ R  S    S+  + G Q GK R RS + C+          S  I    S P  S  +
Sbjct: 226  KRTRVASSSQRSRGSKVGRQPGKTRNRSGMACKTTAT----TSSKRIVRRASLPSLSLKK 281

Query: 1138 SQKSSSKLNEEDEVI----LLLDSDEELELEQTKMKSISSDPLEEKKALEISPRSCELFS 1193
                 S   +   V+    L L ++E L+   +K ++      EEK A + SP      +
Sbjct: 282  PIILRSSGCQVPTVLRRGYLQLFTEECLKFCASKQEAEEKALNEEKVAYDCSPNKNRYLN 341

Query: 1194 IIDVDADQ----EPSQSPPRSEAVLQQE------DEGALPENRGSL---GRRGAPWLFCD 1240
            ++     +     PS  P  S A L          +  L EN        R G   LF  
Sbjct: 342  VVLNTLKRLKGLTPSSMPGLSRAALYSRLQEFLLTQDQLKENGYPFPHPERPGGAVLFTG 401

Query: 1241 RESSPSEAS-----TTDTSWLVPATPLASRSRDCS---SQTQISSLRSGLAVQAVTQHTP 1292
            +   P ++S        T +LV ++    R + C     + + S +  G     V+Q+T 
Sbjct: 402  QGKGPGDSSCRVCCRCGTEYLVSSSGRCVRDQLCYYHWGRVRSSQVAGG----RVSQYTC 457

Query: 1293 RASVGNREGNEVAQK 1307
             A+     G +VA++
Sbjct: 458  CAAAPGSVGCQVAKQ 472


>gi|155030232 proline, glutamic acid and leucine rich protein 1 [Homo
            sapiens]
          Length = 1130

 Score = 43.5 bits (101), Expect = 0.002
 Identities = 56/227 (24%), Positives = 89/227 (39%), Gaps = 28/227 (12%)

Query: 757  TADTGLPPGLSSELSSLAHRFGVSELVHLCEQVPIATDSEGKPWEEKEAENCESRAENFQ 816
            T   G PP L  +L+          ++++        + E +  EE+E E  E   E  +
Sbjct: 865  TPGGGGPPALEEDLT----------VININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEE 914

Query: 817  ELLRSMWADEEEEAETLLKSKDHEEDQENVNEAEMEEIYEFAATQRKLLQEERAAGAGED 876
            E     + +EEEE E     ++ EE++  + E E EE  E    + + L+E      G  
Sbjct: 915  EDEEEYFEEEEEEEEEF--EEEFEEEEGELEEEEEEEDEE----EEEELEEVEDLEFGTA 968

Query: 877  ADWLEGGSPVSGQLLAGVQVQKQWDKVEEMEPLEPG---RDEAATTWEKMGQCALP---- 929
               +E G+P    L   +   +   KV+     EPG     E   T E+ G    P    
Sbjct: 969  GGEVEEGAPPPPTLPPALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGADTAPTLAP 1028

Query: 930  ---PPQGQHSGARGAEAPEQEAPEEALGHSSCSSPSRDCQAERKEGS 973
               P QG+    R  E+P    P + L     S+P    + E ++GS
Sbjct: 1029 EALPSQGEVE--REGESPAAGPPPQELVEEEPSAPPTLLEEETEDGS 1073



 Score = 31.6 bits (70), Expect = 7.4
 Identities = 66/321 (20%), Positives = 105/321 (32%), Gaps = 77/321 (23%)

Query: 924  GQCALPPPQGQHSGARGAEAP---------------------EQEAPEEALGHSSCSSPS 962
            G   LPPPQ    G  G   P                     E+E  EE           
Sbjct: 851  GPVTLPPPQLVPEGTPGGGGPPALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDF 910

Query: 963  RDCQAERKEGSLPHSDDAGDYEQLFSSTQGEISEPSQITSEPEEQ------------SGA 1010
             + + + +E      ++  ++E+ F   +GE+ E  +   E EE+            +G 
Sbjct: 911  EEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGTAGG 970

Query: 1011 VRERGLEVSHRLAPWQASPPHPCRFLLGPPQGGSPRGSHHTSGSSLSTPRSRGGTSQVGS 1070
              E G      L P    P  P +    P     P            T   RG  +   +
Sbjct: 971  EVEEGAPPPPTLPPALPPPESPPKVQPEP----EPEPGLLLEVEEPGTEEERGADT---A 1023

Query: 1071 PTLLSPAVPSKQKRDRSILTLSKEPGHQKGKERRSVLECRNKGVLMFPEKSPSIDLTQSN 1130
            PTL   A+PS+ + +R   + +  P  Q+                   E+ PS     + 
Sbjct: 1024 PTLAPEALPSQGEVEREGESPAAGPPPQE-----------------LVEEEPS-----AP 1061

Query: 1131 PDHSSSRSQKSSSKLNEEDEVILLLDSDEELELEQTKMKSISSDPLEEKKALEISPRSCE 1190
            P      ++  S K+    E      ++EE+E E        ++ L+EK   E    +  
Sbjct: 1062 PTLLEEETEDGSDKVQPPPET----PAEEEMETE------TEAEALQEK---EQDDTAAM 1108

Query: 1191 LFSIIDVDADQEPSQSPPRSE 1211
            L   ID   D E  + PP +E
Sbjct: 1109 LADFIDCPPDDE--KPPPPTE 1127


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.128    0.372 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 88,035,816
Number of Sequences: 37866
Number of extensions: 5226146
Number of successful extensions: 30619
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 49
Number of HSP's successfully gapped in prelim test: 899
Number of HSP's that attempted gapping in prelim test: 25456
Number of HSP's gapped (non-prelim): 6197
length of query: 1834
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1717
effective length of database: 13,817,196
effective search space: 23724125532
effective search space used: 23724125532
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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