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Search of human proteins with 63054845
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|63054845 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo
sapiens]
(427 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|63054845 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo ... 868 0.0
gi|4507883 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo s... 868 0.0
gi|11863132 nuclear receptor subfamily 1, group I, member 2 isof... 300 1e-81
gi|34398348 nuclear receptor subfamily 1, group I, member 2 isof... 300 1e-81
gi|14702164 nuclear receptor subfamily 1, group I, member 2 isof... 289 3e-78
gi|194294519 nuclear receptor subfamily 1, group H, member 3 iso... 209 4e-54
gi|194294517 nuclear receptor subfamily 1, group H, member 3 iso... 209 4e-54
gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Hom... 197 1e-50
gi|4826980 nuclear receptor subfamily 1, group H, member 4 [Homo... 170 3e-42
gi|189491771 thyroid hormone receptor, beta [Homo sapiens] 160 2e-39
gi|189491769 thyroid hormone receptor, beta [Homo sapiens] 160 2e-39
gi|40806162 thyroid hormone receptor, beta [Homo sapiens] 160 2e-39
gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo sapi... 156 4e-38
gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens] 156 4e-38
gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens] 156 4e-38
gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 150 3e-36
gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens] 150 3e-36
gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 150 3e-36
gi|20127452 thyroid hormone receptor, alpha isoform 2 [Homo sapi... 139 5e-33
gi|117938756 constitutive androstane receptor isoform 1 [Homo sa... 139 5e-33
gi|117938754 constitutive androstane receptor isoform 4 [Homo sa... 139 5e-33
gi|117938752 constitutive androstane receptor isoform 2 [Homo sa... 139 5e-33
gi|117938746 constitutive androstane receptor isoform 7 [Homo sa... 139 5e-33
gi|117938740 constitutive androstane receptor isoform 8 [Homo sa... 139 5e-33
gi|117938734 constitutive androstane receptor isoform 5 [Homo sa... 139 5e-33
gi|117938729 constitutive androstane receptor isoform 6 [Homo sa... 139 5e-33
gi|4826661 constitutive androstane receptor isoform 3 [Homo sapi... 139 5e-33
gi|50348666 peroxisome proliferative activated receptor, alpha [... 136 3e-32
gi|7549811 peroxisome proliferative activated receptor, alpha [H... 136 3e-32
gi|117938750 constitutive androstane receptor isoform 10 [Homo s... 130 2e-30
>gi|63054845 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo
sapiens]
Length = 427
Score = 868 bits (2244), Expect = 0.0
Identities = 427/427 (100%), Positives = 427/427 (100%)
Query: 1 MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTC 60
MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTC
Sbjct: 1 MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTC 60
Query: 61 PFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSL 120
PFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSL
Sbjct: 61 PFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSL 120
Query: 121 RPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSG 180
RPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSG
Sbjct: 121 RPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSG 180
Query: 181 DSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQK 240
DSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQK
Sbjct: 181 DSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQK 240
Query: 241 VIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDV 300
VIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDV
Sbjct: 241 VIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDV 300
Query: 301 TKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLS 360
TKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLS
Sbjct: 301 TKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLS 360
Query: 361 NTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLE 420
NTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLE
Sbjct: 361 NTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLE 420
Query: 421 VFGNEIS 427
VFGNEIS
Sbjct: 421 VFGNEIS 427
>gi|4507883 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo
sapiens]
Length = 427
Score = 868 bits (2244), Expect = 0.0
Identities = 427/427 (100%), Positives = 427/427 (100%)
Query: 1 MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTC 60
MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTC
Sbjct: 1 MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTC 60
Query: 61 PFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSL 120
PFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSL
Sbjct: 61 PFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSL 120
Query: 121 RPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSG 180
RPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSG
Sbjct: 121 RPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSG 180
Query: 181 DSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQK 240
DSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQK
Sbjct: 181 DSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQK 240
Query: 241 VIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDV 300
VIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDV
Sbjct: 241 VIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDV 300
Query: 301 TKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLS 360
TKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLS
Sbjct: 301 TKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLS 360
Query: 361 NTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLE 420
NTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLE
Sbjct: 361 NTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLE 420
Query: 421 VFGNEIS 427
VFGNEIS
Sbjct: 421 VFGNEIS 427
>gi|11863132 nuclear receptor subfamily 1, group I, member 2 isoform
2 [Homo sapiens]
Length = 473
Score = 300 bits (769), Expect = 1e-81
Identities = 170/405 (41%), Positives = 240/405 (59%), Gaps = 14/405 (3%)
Query: 21 PRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFN-GDCRITKDNRRHCQAC 79
P+IC VCGD+ATG+HFN MTCEGCKGFFRR+MKR A CPF G C IT+ RR CQAC
Sbjct: 77 PQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQAC 136
Query: 80 RLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPK-LSEEQQRIIAILLDA 138
RL++C++ GM KE I++DE V+ +R +I ++K E L + L+EEQ+ +I L+DA
Sbjct: 137 RLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDA 196
Query: 139 HHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMD 198
KT+D T+S F FR P ++ G P S PS + ++ S +
Sbjct: 197 QMKTFDTTFSHFKNFRLPGVLSSGC----ELPESLQAPS--REEAAKWSQVRKDLCSLKV 250
Query: 199 SSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSED 258
S D S + P+ + S+LPH+AD+ +Y + +I FAK+I FRDL ED
Sbjct: 251 SLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIED 310
Query: 259 QIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQV 318
QI LLK +A E+ LR N F + +W CG Y + T G L+EP++KF
Sbjct: 311 QISLLKGAAFELCQLRFNTVFNAETGTWECGRLSY---CLEDTAGGFQQLLLEPMLKFHY 367
Query: 319 GLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHL 378
LKKL LHEEE+VL+ AI + SPDRPGV +++ +Q++ + TL++YI C P P
Sbjct: 368 MLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRF 427
Query: 379 LYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVFG 423
L+ K++ L +LRS+N +H++ R L Q + TPL+ E+FG
Sbjct: 428 LFLKIMAMLTELRSINAQHTQ--RLLRIQ-DIHPFATPLMQELFG 469
>gi|34398348 nuclear receptor subfamily 1, group I, member 2 isoform
1 [Homo sapiens]
Length = 434
Score = 300 bits (769), Expect = 1e-81
Identities = 170/405 (41%), Positives = 240/405 (59%), Gaps = 14/405 (3%)
Query: 21 PRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFN-GDCRITKDNRRHCQAC 79
P+IC VCGD+ATG+HFN MTCEGCKGFFRR+MKR A CPF G C IT+ RR CQAC
Sbjct: 38 PQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQAC 97
Query: 80 RLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPK-LSEEQQRIIAILLDA 138
RL++C++ GM KE I++DE V+ +R +I ++K E L + L+EEQ+ +I L+DA
Sbjct: 98 RLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDA 157
Query: 139 HHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMD 198
KT+D T+S F FR P ++ G P S PS + ++ S +
Sbjct: 158 QMKTFDTTFSHFKNFRLPGVLSSGC----ELPESLQAPS--REEAAKWSQVRKDLCSLKV 211
Query: 199 SSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSED 258
S D S + P+ + S+LPH+AD+ +Y + +I FAK+I FRDL ED
Sbjct: 212 SLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIED 271
Query: 259 QIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQV 318
QI LLK +A E+ LR N F + +W CG Y + T G L+EP++KF
Sbjct: 272 QISLLKGAAFELCQLRFNTVFNAETGTWECGRLSY---CLEDTAGGFQQLLLEPMLKFHY 328
Query: 319 GLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHL 378
LKKL LHEEE+VL+ AI + SPDRPGV +++ +Q++ + TL++YI C P P
Sbjct: 329 MLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRF 388
Query: 379 LYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVFG 423
L+ K++ L +LRS+N +H++ R L Q + TPL+ E+FG
Sbjct: 389 LFLKIMAMLTELRSINAQHTQ--RLLRIQ-DIHPFATPLMQELFG 430
>gi|14702164 nuclear receptor subfamily 1, group I, member 2 isoform
3 [Homo sapiens]
Length = 397
Score = 289 bits (740), Expect = 3e-78
Identities = 164/405 (40%), Positives = 230/405 (56%), Gaps = 51/405 (12%)
Query: 21 PRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFN-GDCRITKDNRRHCQAC 79
P+IC VCGD+ATG+HFN MTCEGCKGFFRR+MKR A CPF G C IT+ RR CQAC
Sbjct: 38 PQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQAC 97
Query: 80 RLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPK-LSEEQQRIIAILLDA 138
RL++C++ GM KE I++DE V+ +R +I ++K E L + L+EEQ+ +I L+DA
Sbjct: 98 RLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDA 157
Query: 139 HHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMD 198
KT+D T+S F FR +++ GS + P+ SG
Sbjct: 158 QMKTFDTTFSHFKNFRVSLQLRGEDGS----VWNYKPPADSGGKEI-------------- 199
Query: 199 SSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSED 258
S+LPH+AD+ +Y + +I FAK+I FRDL ED
Sbjct: 200 -------------------------FSLLPHMADMSTYMFKGIISFAKVISYFRDLPIED 234
Query: 259 QIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQV 318
QI LLK +A E+ LR N F + +W CG Y + T G L+EP++KF
Sbjct: 235 QISLLKGAAFELCQLRFNTVFNAETGTWECGRLSY---CLEDTAGGFQQLLLEPMLKFHY 291
Query: 319 GLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHL 378
LKKL LHEEE+VL+ AI + SPDRPGV +++ +Q++ + TL++YI C P P
Sbjct: 292 MLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRF 351
Query: 379 LYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVFG 423
L+ K++ L +LRS+N +H++ R L Q + TPL+ E+FG
Sbjct: 352 LFLKIMAMLTELRSINAQHTQ--RLLRIQ-DIHPFATPLMQELFG 393
>gi|194294519 nuclear receptor subfamily 1, group H, member 3
isoform c [Homo sapiens]
Length = 402
Score = 209 bits (532), Expect = 4e-54
Identities = 130/400 (32%), Positives = 197/400 (49%), Gaps = 53/400 (13%)
Query: 23 ICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLK 82
+C VCGD+A+GFH+N ++CEGCKGFFRRS+ + A + C G C + RR CQ CRL+
Sbjct: 52 LCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLR 111
Query: 83 RCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKT 142
+C GM +E +L++E+++ K+ LKR+EEE AH +
Sbjct: 112 KCRQAGMREECVLSEEQIRLKK---LKRQEEE----------------------QAHATS 146
Query: 143 YDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSF 202
P S Q P + G + + + + SF
Sbjct: 147 LPPRASSPPQILPQLSPEQLG----------------------MIEKLVAAQQQCNRRSF 184
Query: 203 SNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVL 262
S+ P ++ H +L S+Q+++ FAK +PGF L+ EDQI L
Sbjct: 185 SDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIAL 244
Query: 263 LKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKK 322
LK+SAIEV++L ++ + S T +D+ Y D KAG +E I P+ +F + +
Sbjct: 245 LKTSAIEVMLLETSRRYNPGSESITF-LKDFSYNREDFAKAGLQVEFINPIFEFSRAMNE 303
Query: 323 LNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAK 382
L L++ E LL+AI I S DRP VQD +E +Q L Y+ H P L++ +
Sbjct: 304 LQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHH--PHDRLMFPR 361
Query: 383 MIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVF 422
M+ KL LR+L+ HS+Q L Q + KL PL+ E++
Sbjct: 362 MLMKLVSLRTLSSVHSEQVFALRLQDK---KLPPLLSEIW 398
>gi|194294517 nuclear receptor subfamily 1, group H, member 3
isoform a [Homo sapiens]
Length = 447
Score = 209 bits (532), Expect = 4e-54
Identities = 130/400 (32%), Positives = 197/400 (49%), Gaps = 53/400 (13%)
Query: 23 ICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLK 82
+C VCGD+A+GFH+N ++CEGCKGFFRRS+ + A + C G C + RR CQ CRL+
Sbjct: 97 LCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLR 156
Query: 83 RCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKT 142
+C GM +E +L++E+++ K+ LKR+EEE AH +
Sbjct: 157 KCRQAGMREECVLSEEQIRLKK---LKRQEEE----------------------QAHATS 191
Query: 143 YDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSF 202
P S Q P + G + + + + SF
Sbjct: 192 LPPRASSPPQILPQLSPEQLG----------------------MIEKLVAAQQQCNRRSF 229
Query: 203 SNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVL 262
S+ P ++ H +L S+Q+++ FAK +PGF L+ EDQI L
Sbjct: 230 SDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIAL 289
Query: 263 LKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKK 322
LK+SAIEV++L ++ + S T +D+ Y D KAG +E I P+ +F + +
Sbjct: 290 LKTSAIEVMLLETSRRYNPGSESITF-LKDFSYNREDFAKAGLQVEFINPIFEFSRAMNE 348
Query: 323 LNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAK 382
L L++ E LL+AI I S DRP VQD +E +Q L Y+ H P L++ +
Sbjct: 349 LQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHH--PHDRLMFPR 406
Query: 383 MIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVF 422
M+ KL LR+L+ HS+Q L Q + KL PL+ E++
Sbjct: 407 MLMKLVSLRTLSSVHSEQVFALRLQDK---KLPPLLSEIW 443
>gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Homo
sapiens]
Length = 461
Score = 197 bits (502), Expect = 1e-50
Identities = 128/415 (30%), Positives = 209/415 (50%), Gaps = 58/415 (13%)
Query: 23 ICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKAL--FTCPFNGDCRITKDNRRHCQACR 80
+C VCGD+A+GFH+N ++CEGCKGFFRRS+ R + C G C++ RR CQ CR
Sbjct: 86 LCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCR 145
Query: 81 LKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHH 140
L++C + GM ++ +L++E++++K+ I K++++E+ S P +
Sbjct: 146 LRKCKEAGMREQCVLSEEQIRKKK--IRKQQQQESQSQSQSPVGPQ-------------- 189
Query: 141 KTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHC-ITSSD--MM 197
G S S P + S +G S + +T++ M+
Sbjct: 190 ---------------------GSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMI 228
Query: 198 DSSSFSNLDLSEED-SDDPSVT---------LELSQLSMLPHLADLVSYSIQKVIGFAKM 247
+ L ++ SD P VT ++ H +L S+Q+++ FAK
Sbjct: 229 QQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQ 288
Query: 248 IPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSL 307
+PGF L EDQI LLK+S IE+++L + + + T +D+ Y D +AG +
Sbjct: 289 VPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITF-LKDFTYSKDDFHRAGLQV 347
Query: 308 ELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYI 367
E I P+ +F +++L L + E+ LL+AI I S DRP VQ+ +EA+Q L +Y
Sbjct: 348 EFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYT 407
Query: 368 RCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVF 422
R + P L + +M+ KL LR+L+ HS+Q L Q + KL PL+ E++
Sbjct: 408 RIKRPQ--DQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDK---KLPPLLSEIW 457
>gi|4826980 nuclear receptor subfamily 1, group H, member 4 [Homo
sapiens]
Length = 472
Score = 170 bits (430), Expect = 3e-42
Identities = 121/400 (30%), Positives = 198/400 (49%), Gaps = 56/400 (14%)
Query: 23 ICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLK 82
+C VCGDRA+G+H+NA+TCEGCKGFFRRS+ + A++ C G+C + RR CQ CRL+
Sbjct: 126 LCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQECRLR 185
Query: 83 RCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKT 142
+C ++GM+ E +LT E+Q K + + K ++ A + + +++ + KT
Sbjct: 186 KCKEMGMLAECLLT--EIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCREKT 243
Query: 143 YDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSF 202
P+ + F DS +
Sbjct: 244 ------------------------ELTPDQQTLLHFIMDSYNK----------QRMPQEI 269
Query: 203 SNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVL 262
+N L EE S + + L L++++ H+ LV ++ K +PGF+ L EDQI L
Sbjct: 270 TNKILKEEFSAEENF-LILTEMA-TNHVQVLVEFT--------KKLPGFQTLDHEDQIAL 319
Query: 263 LKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKK 322
LK SA+E + LRS E F + G+ D + +G S E I P+ F + +
Sbjct: 320 LKGSAVEAMFLRSAEIF---NKKLPSGHSD--LLEERIRNSGISDEYITPMFSFYKSIGE 374
Query: 323 LNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAK 382
L + +EE+ LL AI I+SPDR ++D +E +Q+ L + LQ + P H +A
Sbjct: 375 LKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCKIHQPENPQH--FAC 432
Query: 383 MIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVF 422
++ +L +LR+ N H++ +S++ K TPL+ E++
Sbjct: 433 LLGRLTELRTFNHHHAEM--LMSWRVN-DHKFTPLLCEIW 469
>gi|189491771 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 160 bits (406), Expect = 2e-39
Identities = 115/410 (28%), Positives = 195/410 (47%), Gaps = 66/410 (16%)
Query: 23 ICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRK--ALFTCPFNGDCRITKDNRRHCQACR 80
+C VCGD+ATG+H+ +TCEGCKGFFRR++++ ++C + G C I K R CQ CR
Sbjct: 106 LCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECR 165
Query: 81 LKRCVDIGMMKEFILTDEEVQRKREMILKRKEE---EALKDSL--RPKLSEEQQRIIAIL 135
K+C+ +GM + +L D + KR++I + +E+ E L+ S+ +P+ ++E+ +I +
Sbjct: 166 FKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTV 225
Query: 136 LDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSD 195
+AH T + GSH + + P G +
Sbjct: 226 TEAHVAT------------------NAQGSH-WKQKRKFLPEDIG------------QAP 254
Query: 196 MMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLT 255
++++ +D L H +++ +I +V+ FAK +P F +L
Sbjct: 255 IVNAPEGGKVD-----------------LEAFSHFTKIITPAITRVVDFAKKLPMFCELP 297
Query: 256 SEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIK 315
EDQI+LLK +E++ LR+ + + + T + R K G + + +
Sbjct: 298 CEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTR--GQLKNGGLGVVSDAIFD 355
Query: 316 FQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPG 375
+ L NL + E LL A+ ++S DRPG+ IE QD + YI R
Sbjct: 356 LGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRK---- 411
Query: 376 SHL--LYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKL-TPLVLEVF 422
H+ + K++ K+ DLR + H+ ++ L + EC +L PL LEVF
Sbjct: 412 HHVTHFWPKLLMKVTDLRMIGACHASRF--LHMKVECPTELFPPLFLEVF 459
>gi|189491769 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 160 bits (406), Expect = 2e-39
Identities = 115/410 (28%), Positives = 195/410 (47%), Gaps = 66/410 (16%)
Query: 23 ICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRK--ALFTCPFNGDCRITKDNRRHCQACR 80
+C VCGD+ATG+H+ +TCEGCKGFFRR++++ ++C + G C I K R CQ CR
Sbjct: 106 LCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECR 165
Query: 81 LKRCVDIGMMKEFILTDEEVQRKREMILKRKEE---EALKDSL--RPKLSEEQQRIIAIL 135
K+C+ +GM + +L D + KR++I + +E+ E L+ S+ +P+ ++E+ +I +
Sbjct: 166 FKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTV 225
Query: 136 LDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSD 195
+AH T + GSH + + P G +
Sbjct: 226 TEAHVAT------------------NAQGSH-WKQKRKFLPEDIG------------QAP 254
Query: 196 MMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLT 255
++++ +D L H +++ +I +V+ FAK +P F +L
Sbjct: 255 IVNAPEGGKVD-----------------LEAFSHFTKIITPAITRVVDFAKKLPMFCELP 297
Query: 256 SEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIK 315
EDQI+LLK +E++ LR+ + + + T + R K G + + +
Sbjct: 298 CEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTR--GQLKNGGLGVVSDAIFD 355
Query: 316 FQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPG 375
+ L NL + E LL A+ ++S DRPG+ IE QD + YI R
Sbjct: 356 LGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRK---- 411
Query: 376 SHL--LYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKL-TPLVLEVF 422
H+ + K++ K+ DLR + H+ ++ L + EC +L PL LEVF
Sbjct: 412 HHVTHFWPKLLMKVTDLRMIGACHASRF--LHMKVECPTELFPPLFLEVF 459
>gi|40806162 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 160 bits (406), Expect = 2e-39
Identities = 115/410 (28%), Positives = 195/410 (47%), Gaps = 66/410 (16%)
Query: 23 ICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRK--ALFTCPFNGDCRITKDNRRHCQACR 80
+C VCGD+ATG+H+ +TCEGCKGFFRR++++ ++C + G C I K R CQ CR
Sbjct: 106 LCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECR 165
Query: 81 LKRCVDIGMMKEFILTDEEVQRKREMILKRKEE---EALKDSL--RPKLSEEQQRIIAIL 135
K+C+ +GM + +L D + KR++I + +E+ E L+ S+ +P+ ++E+ +I +
Sbjct: 166 FKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTV 225
Query: 136 LDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSD 195
+AH T + GSH + + P G +
Sbjct: 226 TEAHVAT------------------NAQGSH-WKQKRKFLPEDIG------------QAP 254
Query: 196 MMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLT 255
++++ +D L H +++ +I +V+ FAK +P F +L
Sbjct: 255 IVNAPEGGKVD-----------------LEAFSHFTKIITPAITRVVDFAKKLPMFCELP 297
Query: 256 SEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIK 315
EDQI+LLK +E++ LR+ + + + T + R K G + + +
Sbjct: 298 CEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTR--GQLKNGGLGVVSDAIFD 355
Query: 316 FQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPG 375
+ L NL + E LL A+ ++S DRPG+ IE QD + YI R
Sbjct: 356 LGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRK---- 411
Query: 376 SHL--LYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKL-TPLVLEVF 422
H+ + K++ K+ DLR + H+ ++ L + EC +L PL LEVF
Sbjct: 412 HHVTHFWPKLLMKVTDLRMIGACHASRF--LHMKVECPTELFPPLFLEVF 459
>gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo
sapiens]
Length = 410
Score = 156 bits (394), Expect = 4e-38
Identities = 115/411 (27%), Positives = 188/411 (45%), Gaps = 64/411 (15%)
Query: 24 CGVCGDRATGFHFNAMTCEGCKGFFRRSMKRK--ALFTCPFNGDCRITKDNRRHCQACRL 81
C VCGD+ATG+H+ +TCEGCKGFFRR++++ ++C ++ C I K R CQ CR
Sbjct: 53 CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRF 112
Query: 82 KRCVDIGMMKEFILTDEEVQRKREMI-----LKRKEEEALKDSLRPKLSEEQQRIIAILL 136
K+C+ +GM + +L D + KR++I +RKEE RP+ + E+ +I I
Sbjct: 113 KKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIAT 172
Query: 137 DAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDM 196
+AH T + GSH + F D + D
Sbjct: 173 EAHRST------------------NAQGSH-----WKQRRKFLPDDIGQSPIVSMPDGDK 209
Query: 197 MDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTS 256
+D +FS +++ +I +V+ FAK +P F +L
Sbjct: 210 VDLEAFS-------------------------EFTKIITPAITRVVDFAKKLPMFSELPC 244
Query: 257 EDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKF 316
EDQI+LLK +E++ LR+ + + + T + R + K G + + + +
Sbjct: 245 EDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKR--EQLKNGGLGVVSDAIFEL 302
Query: 317 QVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCR-HPPPG 375
L NL + E LL A+ ++S DR G+ IE Q+ + Y+ R H P
Sbjct: 303 GKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPH 362
Query: 376 SHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKL-TPLVLEVFGNE 425
+ K++ K+ DLR + H+ ++ L + EC +L PL LEVF ++
Sbjct: 363 ---FWPKLLMKVTDLRMIGACHASRF--LHMKVECPTELFPPLFLEVFEDQ 408
>gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]
Length = 443
Score = 156 bits (394), Expect = 4e-38
Identities = 117/425 (27%), Positives = 204/425 (48%), Gaps = 79/425 (18%)
Query: 2 EAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCP 61
E M S+ P P V + C VC D+++G+H+ +CEGCKGFFRRS+++ ++TC
Sbjct: 60 EEMVPSSPSPPPPP---RVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCH 116
Query: 62 FNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLR 121
+ +C I K R CQ CRL++C ++GM KE + D ++K+E+ +EE DS
Sbjct: 117 RDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRN-KKKKEV-----KEEGSPDSY- 169
Query: 122 PKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGD 181
+LS + + +I + AH + T+ CQ G +
Sbjct: 170 -ELSPQLEELITKVSKAHQE----TFPSLCQL----------GKY--------------- 199
Query: 182 SSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKV 241
+++S +DH + LDL D ++L + I K+
Sbjct: 200 TTNSSADHRV------------QLDLGLWDK-----------------FSELATKCIIKI 230
Query: 242 IGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFT--MDDMSWTCGNQDYKYRVSD 299
+ FAK +PGF L+ DQI LLK++ ++++MLR +T D M+++ G +
Sbjct: 231 VEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDG---LTLNRTQ 287
Query: 300 VTKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRL 359
+ AG L + + F L L + + E LL AIC++ DR +++ ++ +Q+ L
Sbjct: 288 MHNAGFG-PLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPL 346
Query: 360 SNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVL 419
L+ Y R R P ++ +M+ K+ DLR ++ + ++ R ++ + E + PL+
Sbjct: 347 LEALRLYARRRR--PSQPYMFPRMLMKITDLRGISTKGAE--RAITLKMEIPGPMPPLIR 402
Query: 420 EVFGN 424
E+ N
Sbjct: 403 EMLEN 407
>gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]
Length = 454
Score = 156 bits (394), Expect = 4e-38
Identities = 117/425 (27%), Positives = 204/425 (48%), Gaps = 79/425 (18%)
Query: 2 EAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCP 61
E M S+ P P V + C VC D+++G+H+ +CEGCKGFFRRS+++ ++TC
Sbjct: 71 EEMVPSSPSPPPPP---RVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCH 127
Query: 62 FNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLR 121
+ +C I K R CQ CRL++C ++GM KE + D ++K+E+ +EE DS
Sbjct: 128 RDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRN-KKKKEV-----KEEGSPDSY- 180
Query: 122 PKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGD 181
+LS + + +I + AH + T+ CQ G +
Sbjct: 181 -ELSPQLEELITKVSKAHQE----TFPSLCQL----------GKY--------------- 210
Query: 182 SSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKV 241
+++S +DH + LDL D ++L + I K+
Sbjct: 211 TTNSSADHRV------------QLDLGLWDK-----------------FSELATKCIIKI 241
Query: 242 IGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFT--MDDMSWTCGNQDYKYRVSD 299
+ FAK +PGF L+ DQI LLK++ ++++MLR +T D M+++ G +
Sbjct: 242 VEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDG---LTLNRTQ 298
Query: 300 VTKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRL 359
+ AG L + + F L L + + E LL AIC++ DR +++ ++ +Q+ L
Sbjct: 299 MHNAGFG-PLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPL 357
Query: 360 SNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVL 419
L+ Y R R P ++ +M+ K+ DLR ++ + ++ R ++ + E + PL+
Sbjct: 358 LEALRLYARRRR--PSQPYMFPRMLMKITDLRGISTKGAE--RAITLKMEIPGPMPPLIR 413
Query: 420 EVFGN 424
E+ N
Sbjct: 414 EMLEN 418
>gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 150 bits (378), Expect = 3e-36
Identities = 110/410 (26%), Positives = 196/410 (47%), Gaps = 79/410 (19%)
Query: 20 VPRI---CGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHC 76
+PRI C VC D+++G+H+ CEGCKGFFRRS+++ ++TC + +C I K R C
Sbjct: 81 LPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRC 140
Query: 77 QACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILL 136
Q CRL++C ++GM KE + D ++K+E+ K E + +L P++ E L+
Sbjct: 141 QYCRLQKCFEVGMSKESVRNDRN-KKKKEV---PKPECSESYTLTPEVGE--------LI 188
Query: 137 DAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDM 196
+ K + T+ CQ ++T +
Sbjct: 189 EKVRKAHQETFPALCQL------------------GKYTTN------------------- 211
Query: 197 MDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTS 256
+S + V+L+ + + ++L + I K + FAK +PGF LT
Sbjct: 212 --------------NSSEQRVSLD---IDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTI 254
Query: 257 EDQIVLLKSSAIEVIMLRSNESFT--MDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLI 314
DQI LLK++ +++++LR +T D M+++ G + + AG L + +
Sbjct: 255 ADQITLLKAACLDILILRICTRYTPEQDTMTFSDG---LTLNRTQMHNAGFG-PLTDLVF 310
Query: 315 KFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPP 374
F L L + + E LL AIC++ DR ++ ++ +Q+ L L+ Y+R R P
Sbjct: 311 AFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRR--P 368
Query: 375 GSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVFGN 424
++ KM+ K+ DLRS++ + ++ R ++ + E + PL+ E+ N
Sbjct: 369 SRPHMFPKMLMKITDLRSISAKGAE--RVITLKMEIPGSMPPLIQEMLEN 416
>gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]
Length = 457
Score = 150 bits (378), Expect = 3e-36
Identities = 110/410 (26%), Positives = 196/410 (47%), Gaps = 79/410 (19%)
Query: 20 VPRI---CGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHC 76
+PRI C VC D+++G+H+ CEGCKGFFRRS+++ ++TC + +C I K R C
Sbjct: 76 LPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRC 135
Query: 77 QACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILL 136
Q CRL++C ++GM KE + D ++K+E+ K E + +L P++ E L+
Sbjct: 136 QYCRLQKCFEVGMSKESVRNDRN-KKKKEV---PKPECSESYTLTPEVGE--------LI 183
Query: 137 DAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDM 196
+ K + T+ CQ ++T +
Sbjct: 184 EKVRKAHQETFPALCQL------------------GKYTTN------------------- 206
Query: 197 MDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTS 256
+S + V+L+ + + ++L + I K + FAK +PGF LT
Sbjct: 207 --------------NSSEQRVSLD---IDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTI 249
Query: 257 EDQIVLLKSSAIEVIMLRSNESFT--MDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLI 314
DQI LLK++ +++++LR +T D M+++ G + + AG L + +
Sbjct: 250 ADQITLLKAACLDILILRICTRYTPEQDTMTFSDG---LTLNRTQMHNAGFG-PLTDLVF 305
Query: 315 KFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPP 374
F L L + + E LL AIC++ DR ++ ++ +Q+ L L+ Y+R R P
Sbjct: 306 AFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRR--P 363
Query: 375 GSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVFGN 424
++ KM+ K+ DLRS++ + ++ R ++ + E + PL+ E+ N
Sbjct: 364 SRPHMFPKMLMKITDLRSISAKGAE--RVITLKMEIPGSMPPLIQEMLEN 411
>gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 150 bits (378), Expect = 3e-36
Identities = 110/410 (26%), Positives = 196/410 (47%), Gaps = 79/410 (19%)
Query: 20 VPRI---CGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHC 76
+PRI C VC D+++G+H+ CEGCKGFFRRS+++ ++TC + +C I K R C
Sbjct: 81 LPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRC 140
Query: 77 QACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILL 136
Q CRL++C ++GM KE + D ++K+E+ K E + +L P++ E L+
Sbjct: 141 QYCRLQKCFEVGMSKESVRNDRN-KKKKEV---PKPECSESYTLTPEVGE--------LI 188
Query: 137 DAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDM 196
+ K + T+ CQ ++T +
Sbjct: 189 EKVRKAHQETFPALCQL------------------GKYTTN------------------- 211
Query: 197 MDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTS 256
+S + V+L+ + + ++L + I K + FAK +PGF LT
Sbjct: 212 --------------NSSEQRVSLD---IDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTI 254
Query: 257 EDQIVLLKSSAIEVIMLRSNESFT--MDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLI 314
DQI LLK++ +++++LR +T D M+++ G + + AG L + +
Sbjct: 255 ADQITLLKAACLDILILRICTRYTPEQDTMTFSDG---LTLNRTQMHNAGFG-PLTDLVF 310
Query: 315 KFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPP 374
F L L + + E LL AIC++ DR ++ ++ +Q+ L L+ Y+R R P
Sbjct: 311 AFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRR--P 368
Query: 375 GSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVFGN 424
++ KM+ K+ DLRS++ + ++ R ++ + E + PL+ E+ N
Sbjct: 369 SRPHMFPKMLMKITDLRSISAKGAE--RVITLKMEIPGSMPPLIQEMLEN 416
>gi|20127452 thyroid hormone receptor, alpha isoform 2 [Homo
sapiens]
Length = 490
Score = 139 bits (350), Expect = 5e-33
Identities = 102/377 (27%), Positives = 169/377 (44%), Gaps = 61/377 (16%)
Query: 24 CGVCGDRATGFHFNAMTCEGCKGFFRRSMKRK--ALFTCPFNGDCRITKDNRRHCQACRL 81
C VCGD+ATG+H+ +TCEGCKGFFRR++++ ++C ++ C I K R CQ CR
Sbjct: 53 CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRF 112
Query: 82 KRCVDIGMMKEFILTDEEVQRKREMI-----LKRKEEEALKDSLRPKLSEEQQRIIAILL 136
K+C+ +GM + +L D + KR++I +RKEE RP+ + E+ +I I
Sbjct: 113 KKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIAT 172
Query: 137 DAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDM 196
+AH T + GSH + F D + D
Sbjct: 173 EAHRST------------------NAQGSH-----WKQRRKFLPDDIGQSPIVSMPDGDK 209
Query: 197 MDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTS 256
+D +FS +++ +I +V+ FAK +P F +L
Sbjct: 210 VDLEAFS-------------------------EFTKIITPAITRVVDFAKKLPMFSELPC 244
Query: 257 EDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKF 316
EDQI+LLK +E++ LR+ + + + T + R + K G + + + +
Sbjct: 245 EDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKR--EQLKNGGLGVVSDAIFEL 302
Query: 317 QVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCR-HPPPG 375
L NL + E LL A+ ++S DR G+ IE Q+ + Y+ R H P
Sbjct: 303 GKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPH 362
Query: 376 SHLLYAKMIQKLADLRS 392
+ K++ K +++S
Sbjct: 363 ---FWPKLLMKEREVQS 376
>gi|117938756 constitutive androstane receptor isoform 1 [Homo
sapiens]
Length = 357
Score = 139 bits (350), Expect = 5e-33
Identities = 64/138 (46%), Positives = 90/138 (65%), Gaps = 5/138 (3%)
Query: 22 RICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRL 81
R C VCGD+ATG+HFNA+TCEGCKGFFRR++ + TCPF G C ++K RRHC ACRL
Sbjct: 9 RNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRL 68
Query: 82 KRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHK 141
++C+D GM K+ IL+ E + +R +R+ ++ +LS+EQ+ +I LL AH +
Sbjct: 69 QKCLDAGMRKDMILSAEALALRRAKQAQRRAQQT-----PVQLSKEQEELIRTLLGAHTR 123
Query: 142 TYDPTYSDFCQFRPPVRV 159
+ F QFRPP +
Sbjct: 124 HMGTMFEQFVQFRPPAHL 141
Score = 119 bits (297), Expect = 7e-27
Identities = 69/186 (37%), Positives = 107/186 (57%), Gaps = 11/186 (5%)
Query: 224 LSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDD 283
L ++ H AD+ ++ + +VI F K +P FR L EDQI LLK +A+E+ + N +F +
Sbjct: 155 LPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQT 214
Query: 284 MSWTCGNQDYKYRVSDVTK----AGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIV 339
++ CG +Y + D + G +E +E L F L+KL L E E+VLL A+ +
Sbjct: 215 QNFLCG--PLRYTIEDGARVSPTVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALF 272
Query: 340 SP-----DRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLN 394
SP DRPGV I+ +Q+ ++ TLQ+YI+ + P LYAK++ LA+LRS+N
Sbjct: 273 SPAPYLTDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSIN 332
Query: 395 EEHSKQ 400
E + Q
Sbjct: 333 EAYGYQ 338
>gi|117938754 constitutive androstane receptor isoform 4 [Homo
sapiens]
Length = 314
Score = 139 bits (350), Expect = 5e-33
Identities = 64/138 (46%), Positives = 90/138 (65%), Gaps = 5/138 (3%)
Query: 22 RICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRL 81
R C VCGD+ATG+HFNA+TCEGCKGFFRR++ + TCPF G C ++K RRHC ACRL
Sbjct: 9 RNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRL 68
Query: 82 KRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHK 141
++C+D GM K+ IL+ E + +R +R+ ++ +LS+EQ+ +I LL AH +
Sbjct: 69 QKCLDAGMRKDMILSAEALALRRAKQAQRRAQQT-----PVQLSKEQEELIRTLLGAHTR 123
Query: 142 TYDPTYSDFCQFRPPVRV 159
+ F QFRPP +
Sbjct: 124 HMGTMFEQFVQFRPPAHL 141
Score = 84.3 bits (207), Expect = 2e-16
Identities = 53/177 (29%), Positives = 86/177 (48%), Gaps = 36/177 (20%)
Query: 224 LSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDD 283
L ++ H AD+ ++ + +VI F K +P FR L EDQI LLK +A+E+ + N +F +
Sbjct: 155 LPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQT 214
Query: 284 MSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDR 343
++ CG +Y + D +A + DR
Sbjct: 215 QNFLCG--PLRYTIEDGARAPY----------------------------------LTDR 238
Query: 344 PGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQ 400
PGV I+ +Q+ ++ TLQ+YI+ + P LYAK++ LA+LRS+NE + Q
Sbjct: 239 PGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQ 295
>gi|117938752 constitutive androstane receptor isoform 2 [Homo
sapiens]
Length = 352
Score = 139 bits (350), Expect = 5e-33
Identities = 64/138 (46%), Positives = 90/138 (65%), Gaps = 5/138 (3%)
Query: 22 RICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRL 81
R C VCGD+ATG+HFNA+TCEGCKGFFRR++ + TCPF G C ++K RRHC ACRL
Sbjct: 9 RNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRL 68
Query: 82 KRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHK 141
++C+D GM K+ IL+ E + +R +R+ ++ +LS+EQ+ +I LL AH +
Sbjct: 69 QKCLDAGMRKDMILSAEALALRRAKQAQRRAQQT-----PVQLSKEQEELIRTLLGAHTR 123
Query: 142 TYDPTYSDFCQFRPPVRV 159
+ F QFRPP +
Sbjct: 124 HMGTMFEQFVQFRPPAHL 141
Score = 125 bits (313), Expect = 1e-28
Identities = 69/181 (38%), Positives = 107/181 (59%), Gaps = 6/181 (3%)
Query: 224 LSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDD 283
L ++ H AD+ ++ + +VI F K +P FR L EDQI LLK +A+E+ + N +F +
Sbjct: 155 LPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQT 214
Query: 284 MSWTCGNQDYKYRVSDVTKA----GHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIV 339
++ CG +Y + D + G +E +E L F L+KL L E E+VLL A+ +
Sbjct: 215 QNFLCG--PLRYTIEDGARVSPTVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALF 272
Query: 340 SPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSK 399
SPDRPGV I+ +Q+ ++ TLQ+YI+ + P LYAK++ LA+LRS+NE +
Sbjct: 273 SPDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGY 332
Query: 400 Q 400
Q
Sbjct: 333 Q 333
>gi|117938746 constitutive androstane receptor isoform 7 [Homo
sapiens]
Length = 339
Score = 139 bits (350), Expect = 5e-33
Identities = 64/138 (46%), Positives = 90/138 (65%), Gaps = 5/138 (3%)
Query: 22 RICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRL 81
R C VCGD+ATG+HFNA+TCEGCKGFFRR++ + TCPF G C ++K RRHC ACRL
Sbjct: 9 RNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRL 68
Query: 82 KRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHK 141
++C+D GM K+ IL+ E + +R +R+ ++ +LS+EQ+ +I LL AH +
Sbjct: 69 QKCLDAGMRKDMILSAEALALRRAKQAQRRAQQT-----PVQLSKEQEELIRTLLGAHTR 123
Query: 142 TYDPTYSDFCQFRPPVRV 159
+ F QFRPP +
Sbjct: 124 HMGTMFEQFVQFRPPAHL 141
Score = 102 bits (255), Expect = 5e-22
Identities = 57/155 (36%), Positives = 90/155 (58%), Gaps = 6/155 (3%)
Query: 224 LSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDD 283
L ++ H AD+ ++ + +VI F K +P FR L EDQI LLK +A+E+ + N +F +
Sbjct: 155 LPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQT 214
Query: 284 MSWTCGNQDYKYRVSDVTKA----GHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIV 339
++ CG +Y + D + G +E +E L F L+KL L E E+VLL A+ +
Sbjct: 215 QNFLCG--PLRYTIEDGARVSPTVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALF 272
Query: 340 SPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPP 374
SPDRPGV I+ +Q+ ++ TLQ+YI+ + P
Sbjct: 273 SPDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRP 307
>gi|117938740 constitutive androstane receptor isoform 8 [Homo
sapiens]
Length = 296
Score = 139 bits (350), Expect = 5e-33
Identities = 64/138 (46%), Positives = 90/138 (65%), Gaps = 5/138 (3%)
Query: 22 RICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRL 81
R C VCGD+ATG+HFNA+TCEGCKGFFRR++ + TCPF G C ++K RRHC ACRL
Sbjct: 9 RNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRL 68
Query: 82 KRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHK 141
++C+D GM K+ IL+ E + +R +R+ ++ +LS+EQ+ +I LL AH +
Sbjct: 69 QKCLDAGMRKDMILSAEALALRRAKQAQRRAQQT-----PVQLSKEQEELIRTLLGAHTR 123
Query: 142 TYDPTYSDFCQFRPPVRV 159
+ F QFRPP +
Sbjct: 124 HMGTMFEQFVQFRPPAHL 141
Score = 59.7 bits (143), Expect = 5e-09
Identities = 40/151 (26%), Positives = 67/151 (44%), Gaps = 41/151 (27%)
Query: 224 LSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDD 283
L ++ H AD+ ++ + +VI F K +P FR L EDQI LLK +A+E+ + N +F +
Sbjct: 155 LPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQT 214
Query: 284 MSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDR 343
++ CG +Y + D + DR
Sbjct: 215 QNFLCG--PLRYTIEDGAR---------------------------------------DR 233
Query: 344 PGVQDAALIEAIQDRLSNTLQTYIRCRHPPP 374
PGV I+ +Q+ ++ TLQ+YI+ + P
Sbjct: 234 PGVTQRDEIDQLQEEMALTLQSYIKGQQRRP 264
>gi|117938734 constitutive androstane receptor isoform 5 [Homo
sapiens]
Length = 309
Score = 139 bits (350), Expect = 5e-33
Identities = 64/138 (46%), Positives = 90/138 (65%), Gaps = 5/138 (3%)
Query: 22 RICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRL 81
R C VCGD+ATG+HFNA+TCEGCKGFFRR++ + TCPF G C ++K RRHC ACRL
Sbjct: 9 RNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRL 68
Query: 82 KRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHK 141
++C+D GM K+ IL+ E + +R +R+ ++ +LS+EQ+ +I LL AH +
Sbjct: 69 QKCLDAGMRKDMILSAEALALRRAKQAQRRAQQT-----PVQLSKEQEELIRTLLGAHTR 123
Query: 142 TYDPTYSDFCQFRPPVRV 159
+ F QFRPP +
Sbjct: 124 HMGTMFEQFVQFRPPAHL 141
Score = 82.0 bits (201), Expect = 9e-16
Identities = 52/177 (29%), Positives = 84/177 (47%), Gaps = 41/177 (23%)
Query: 224 LSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDD 283
L ++ H AD+ ++ + +VI F K +P FR L EDQI LLK +A+E+ + N +F +
Sbjct: 155 LPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQT 214
Query: 284 MSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDR 343
++ CG +Y + D + DR
Sbjct: 215 QNFLCG--PLRYTIEDGAR---------------------------------------DR 233
Query: 344 PGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQ 400
PGV I+ +Q+ ++ TLQ+YI+ + P LYAK++ LA+LRS+NE + Q
Sbjct: 234 PGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQ 290
>gi|117938729 constitutive androstane receptor isoform 6 [Homo
sapiens]
Length = 340
Score = 139 bits (350), Expect = 5e-33
Identities = 64/138 (46%), Positives = 90/138 (65%), Gaps = 5/138 (3%)
Query: 22 RICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRL 81
R C VCGD+ATG+HFNA+TCEGCKGFFRR++ + TCPF G C ++K RRHC ACRL
Sbjct: 9 RNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRL 68
Query: 82 KRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHK 141
++C+D GM K+ IL+ E + +R +R+ ++ +LS+EQ+ +I LL AH +
Sbjct: 69 QKCLDAGMRKDMILSAEALALRRAKQAQRRAQQT-----PVQLSKEQEELIRTLLGAHTR 123
Query: 142 TYDPTYSDFCQFRPPVRV 159
+ F QFRPP +
Sbjct: 124 HMGTMFEQFVQFRPPAHL 141
Score = 102 bits (254), Expect = 7e-22
Identities = 57/156 (36%), Positives = 90/156 (57%), Gaps = 7/156 (4%)
Query: 224 LSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDD 283
L ++ H AD+ ++ + +VI F K +P FR L EDQI LLK +A+E+ + N +F +
Sbjct: 155 LPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQT 214
Query: 284 MSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSP-- 341
++ CG +Y + D + G +E +E L F L+KL L E E+VLL A+ + SP
Sbjct: 215 QNFLCG--PLRYTIEDGARVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPAP 272
Query: 342 ---DRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPP 374
DRPGV I+ +Q+ ++ TLQ+YI+ + P
Sbjct: 273 YLTDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRP 308
>gi|4826661 constitutive androstane receptor isoform 3 [Homo
sapiens]
Length = 348
Score = 139 bits (350), Expect = 5e-33
Identities = 64/138 (46%), Positives = 90/138 (65%), Gaps = 5/138 (3%)
Query: 22 RICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRL 81
R C VCGD+ATG+HFNA+TCEGCKGFFRR++ + TCPF G C ++K RRHC ACRL
Sbjct: 9 RNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRL 68
Query: 82 KRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHK 141
++C+D GM K+ IL+ E + +R +R+ ++ +LS+EQ+ +I LL AH +
Sbjct: 69 QKCLDAGMRKDMILSAEALALRRAKQAQRRAQQT-----PVQLSKEQEELIRTLLGAHTR 123
Query: 142 TYDPTYSDFCQFRPPVRV 159
+ F QFRPP +
Sbjct: 124 HMGTMFEQFVQFRPPAHL 141
Score = 130 bits (328), Expect = 2e-30
Identities = 69/177 (38%), Positives = 107/177 (60%), Gaps = 2/177 (1%)
Query: 224 LSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDD 283
L ++ H AD+ ++ + +VI F K +P FR L EDQI LLK +A+E+ + N +F +
Sbjct: 155 LPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQT 214
Query: 284 MSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDR 343
++ CG +Y + D + G +E +E L F L+KL L E E+VLL A+ + SPDR
Sbjct: 215 QNFLCG--PLRYTIEDGARVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDR 272
Query: 344 PGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQ 400
PGV I+ +Q+ ++ TLQ+YI+ + P LYAK++ LA+LRS+NE + Q
Sbjct: 273 PGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQ 329
>gi|50348666 peroxisome proliferative activated receptor, alpha
[Homo sapiens]
Length = 468
Score = 136 bits (343), Expect = 3e-32
Identities = 106/400 (26%), Positives = 178/400 (44%), Gaps = 38/400 (9%)
Query: 24 CGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKR 83
C +CGD+A+G+H+ CEGCKGFFRR+++ K ++ + C+I K NR CQ CR +
Sbjct: 102 CRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYD-KCDRSCKIQKKNRNKCQYCRFHK 160
Query: 84 CVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKTY 143
C+ +GM I R + R E+ LK + + + A L + Y
Sbjct: 161 CLSVGMSHNAI---------RFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIY 211
Query: 144 DPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSFS 203
+ +F + RV G + S + P D + C M + + +
Sbjct: 212 EAYLKNFNMNKVKARVILSGKA------SNNPPFVIHDMETLC---------MAEKTLVA 256
Query: 204 NLDLSEEDSDDPSVTLELSQLSMLPHLADLVSY-SIQKVIGFAKMIPGFRDLTSEDQIVL 262
L + + + V + H S ++ ++ FAK IPGF +L DQ+ L
Sbjct: 257 KLVANGIQNKEAEVRIF--------HCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTL 308
Query: 263 LKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKK 322
LK E I + D M GN + R + +++EP F +
Sbjct: 309 LKYGVYEAIFAMLSSVMNKDGMLVAYGN-GFITREFLKSLRKPFCDIMEPKFDFAMKFNA 367
Query: 323 LNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAK 382
L L + + L +A I DRPG+ + IE +Q+ + + L+ +++ H P L+ K
Sbjct: 368 LELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNH--PDDIFLFPK 425
Query: 383 MIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVF 422
++QK+ADLR L EH++ + + + E L PL+ E++
Sbjct: 426 LLQKMADLRQLVTEHAQLVQIIK-KTESDAALHPLLQEIY 464
>gi|7549811 peroxisome proliferative activated receptor, alpha [Homo
sapiens]
Length = 468
Score = 136 bits (343), Expect = 3e-32
Identities = 106/400 (26%), Positives = 178/400 (44%), Gaps = 38/400 (9%)
Query: 24 CGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKR 83
C +CGD+A+G+H+ CEGCKGFFRR+++ K ++ + C+I K NR CQ CR +
Sbjct: 102 CRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYD-KCDRSCKIQKKNRNKCQYCRFHK 160
Query: 84 CVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKTY 143
C+ +GM I R + R E+ LK + + + A L + Y
Sbjct: 161 CLSVGMSHNAI---------RFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIY 211
Query: 144 DPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSFS 203
+ +F + RV G + S + P D + C M + + +
Sbjct: 212 EAYLKNFNMNKVKARVILSGKA------SNNPPFVIHDMETLC---------MAEKTLVA 256
Query: 204 NLDLSEEDSDDPSVTLELSQLSMLPHLADLVSY-SIQKVIGFAKMIPGFRDLTSEDQIVL 262
L + + + V + H S ++ ++ FAK IPGF +L DQ+ L
Sbjct: 257 KLVANGIQNKEAEVRIF--------HCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTL 308
Query: 263 LKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKK 322
LK E I + D M GN + R + +++EP F +
Sbjct: 309 LKYGVYEAIFAMLSSVMNKDGMLVAYGN-GFITREFLKSLRKPFCDIMEPKFDFAMKFNA 367
Query: 323 LNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAK 382
L L + + L +A I DRPG+ + IE +Q+ + + L+ +++ H P L+ K
Sbjct: 368 LELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNH--PDDIFLFPK 425
Query: 383 MIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVF 422
++QK+ADLR L EH++ + + + E L PL+ E++
Sbjct: 426 LLQKMADLRQLVTEHAQLVQIIK-KTESDAALHPLLQEIY 464
>gi|117938750 constitutive androstane receptor isoform 10 [Homo
sapiens]
Length = 319
Score = 130 bits (328), Expect = 2e-30
Identities = 69/177 (38%), Positives = 107/177 (60%), Gaps = 2/177 (1%)
Query: 224 LSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDD 283
L ++ H AD+ ++ + +VI F K +P FR L EDQI LLK +A+E+ + N +F +
Sbjct: 126 LPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQT 185
Query: 284 MSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDR 343
++ CG +Y + D + G +E +E L F L+KL L E E+VLL A+ + SPDR
Sbjct: 186 QNFLCG--PLRYTIEDGARVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDR 243
Query: 344 PGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQ 400
PGV I+ +Q+ ++ TLQ+YI+ + P LYAK++ LA+LRS+NE + Q
Sbjct: 244 PGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQ 300
Score = 87.4 bits (215), Expect = 2e-17
Identities = 42/111 (37%), Positives = 65/111 (58%), Gaps = 5/111 (4%)
Query: 49 RRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMIL 108
RR++ + TCPF G C ++K RRHC ACRL++C+D GM K+ IL+ E + +R
Sbjct: 7 RRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQA 66
Query: 109 KRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRV 159
+R+ ++ +LS+EQ+ +I LL AH + + F QFRPP +
Sbjct: 67 QRRAQQT-----PVQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHL 112
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,350,489
Number of Sequences: 37866
Number of extensions: 775167
Number of successful extensions: 3954
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 135
Number of HSP's successfully gapped in prelim test: 28
Number of HSP's that attempted gapping in prelim test: 3228
Number of HSP's gapped (non-prelim): 534
length of query: 427
length of database: 18,247,518
effective HSP length: 105
effective length of query: 322
effective length of database: 14,271,588
effective search space: 4595451336
effective search space used: 4595451336
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.