BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|62420886 discoidin domain receptor family, member 2 precursor [Homo sapiens] (855 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|62420886 discoidin domain receptor family, member 2 precursor... 1753 0.0 gi|62420884 discoidin domain receptor family, member 2 precursor... 1753 0.0 gi|38327632 discoidin domain receptor family, member 1 isoform b... 921 0.0 gi|83977450 discoidin domain receptor family, member 1 isoform a... 912 0.0 gi|83977452 discoidin domain receptor family, member 1 isoform c... 905 0.0 gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isofo... 253 4e-67 gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isofo... 253 4e-67 gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isofo... 248 2e-65 gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isofo... 244 3e-64 gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isofor... 244 3e-64 gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isofo... 244 3e-64 gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isofo... 238 1e-62 gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens] 226 7e-59 gi|4557665 insulin-like growth factor 1 receptor precursor [Homo... 212 1e-54 gi|134152725 receptor tyrosine kinase-like orphan receptor 1 iso... 211 3e-54 gi|19743898 receptor tyrosine kinase-like orphan receptor 2 prec... 204 2e-52 gi|119395738 insulin receptor isoform Short precursor [Homo sapi... 202 8e-52 gi|119395736 insulin receptor isoform Long precursor [Homo sapiens] 202 8e-52 gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 201 2e-51 gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 201 2e-51 gi|21361241 ephrin receptor EphA3 isoform a precursor [Homo sapi... 198 2e-50 gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 196 8e-50 gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 196 8e-50 gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 196 8e-50 gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 196 8e-50 gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 196 8e-50 gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [... 194 2e-49 gi|22902130 PTK7 protein tyrosine kinase 7 isoform d precursor [... 194 2e-49 gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor [... 194 2e-49 gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor [... 194 2e-49 >gi|62420886 discoidin domain receptor family, member 2 precursor [Homo sapiens] Length = 855 Score = 1753 bits (4540), Expect = 0.0 Identities = 855/855 (100%), Positives = 855/855 (100%) Query: 1 MILIPRMLLVLFLLLPILSSAKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKY 60 MILIPRMLLVLFLLLPILSSAKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKY Sbjct: 1 MILIPRMLLVLFLLLPILSSAKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKY 60 Query: 61 GRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKI 120 GRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKI Sbjct: 61 GRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKI 120 Query: 121 NYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRV 180 NYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRV Sbjct: 121 NYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRV 180 Query: 181 ELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLD 240 ELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLD Sbjct: 181 ELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLD 240 Query: 241 DFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFK 300 DFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFK Sbjct: 241 DFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFK 300 Query: 301 EVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFS 360 EVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFS Sbjct: 301 EVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFS 360 Query: 361 EITFQSDAAMYNNSEALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIIL 420 EITFQSDAAMYNNSEALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIIL Sbjct: 361 EITFQSDAAMYNNSEALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIIL 420 Query: 421 WRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSSSPSEQGSNSTYDRIFPLRPD 480 WRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSSSPSEQGSNSTYDRIFPLRPD Sbjct: 421 WRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSSSPSEQGSNSTYDRIFPLRPD 480 Query: 481 YQEPSRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSV 540 YQEPSRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSV Sbjct: 481 YQEPSRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSV 540 Query: 541 PAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSAN 600 PAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSAN Sbjct: 541 PAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSAN 600 Query: 601 QPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENG 660 QPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENG Sbjct: 601 QPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENG 660 Query: 661 DLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGK 720 DLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGK Sbjct: 661 DLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGK 720 Query: 721 NYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWET 780 NYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWET Sbjct: 721 NYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWET 780 Query: 781 FTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRP 840 FTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRP Sbjct: 781 FTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRP 840 Query: 841 SFQEIHLLLLQQGDE 855 SFQEIHLLLLQQGDE Sbjct: 841 SFQEIHLLLLQQGDE 855 >gi|62420884 discoidin domain receptor family, member 2 precursor [Homo sapiens] Length = 855 Score = 1753 bits (4540), Expect = 0.0 Identities = 855/855 (100%), Positives = 855/855 (100%) Query: 1 MILIPRMLLVLFLLLPILSSAKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKY 60 MILIPRMLLVLFLLLPILSSAKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKY Sbjct: 1 MILIPRMLLVLFLLLPILSSAKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKY 60 Query: 61 GRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKI 120 GRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKI Sbjct: 61 GRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKI 120 Query: 121 NYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRV 180 NYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRV Sbjct: 121 NYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRV 180 Query: 181 ELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLD 240 ELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLD Sbjct: 181 ELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLD 240 Query: 241 DFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFK 300 DFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFK Sbjct: 241 DFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFK 300 Query: 301 EVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFS 360 EVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFS Sbjct: 301 EVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFS 360 Query: 361 EITFQSDAAMYNNSEALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIIL 420 EITFQSDAAMYNNSEALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIIL Sbjct: 361 EITFQSDAAMYNNSEALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIIL 420 Query: 421 WRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSSSPSEQGSNSTYDRIFPLRPD 480 WRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSSSPSEQGSNSTYDRIFPLRPD Sbjct: 421 WRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSSSPSEQGSNSTYDRIFPLRPD 480 Query: 481 YQEPSRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSV 540 YQEPSRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSV Sbjct: 481 YQEPSRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSV 540 Query: 541 PAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSAN 600 PAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSAN Sbjct: 541 PAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSAN 600 Query: 601 QPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENG 660 QPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENG Sbjct: 601 QPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENG 660 Query: 661 DLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGK 720 DLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGK Sbjct: 661 DLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGK 720 Query: 721 NYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWET 780 NYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWET Sbjct: 721 NYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWET 780 Query: 781 FTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRP 840 FTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRP Sbjct: 781 FTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRP 840 Query: 841 SFQEIHLLLLQQGDE 855 SFQEIHLLLLQQGDE Sbjct: 841 SFQEIHLLLLQQGDE 855 >gi|38327632 discoidin domain receptor family, member 1 isoform b [Homo sapiens] Length = 876 Score = 921 bits (2381), Expect = 0.0 Identities = 485/891 (54%), Positives = 599/891 (67%), Gaps = 67/891 (7%) Query: 5 PRMLLVLFLLLPILSS---AKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKYG 61 P L L LLL + S K +PA CRY LGM IPD DI+ASS WS+STAA++ Sbjct: 3 PEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAARHS 62 Query: 62 RLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKIN 121 RL+S +GDGAWCP V P + +E+LQ+DL LH + LVGTQGRHAGG G EF+ Y++ Sbjct: 63 RLESSDGDGAWCPAGSVFPKE-EEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRLR 121 Query: 122 YSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRVE 181 YSRDG RW+ W++R G++V+ GN +P + LKDL PP+VAR VRF P D M+VC+RVE Sbjct: 122 YSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRVE 181 Query: 182 LYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDG-AVGYSMTEGLGQLTDGVSGLD 240 LYGC+W DGL+SY AP GQ L +YLNDS YDG VG GLGQL DGV GLD Sbjct: 182 LYGCLWRDGLLSYTAPVGQTMYL--SEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLD 239 Query: 241 DFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFK 300 DF ++ E VWPGYDYVGW N S ++GY+E+ FEFDR+R F M+VHCNNM G ++ Sbjct: 240 DFRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPG 299 Query: 301 EVQCYFR-SEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMF 359 V+C FR A WE + L + +P AR V+VPL R+A ++C++ FA W++F Sbjct: 300 GVECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLF 359 Query: 360 SEITFQSDAAMYNNSEAL----PTSP---------------MAPTTYDPMLKVDDSNTRI 400 SEI+F SD + N+S AL P +P + P P+ K + S T I Sbjct: 360 SEISFISDV-VNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTAI 418 Query: 401 LIGCLVAIIFILLAIIVIILWRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSS 460 LIGCLVAII +LL II ++LWR W+++L KA RR+L++E+TV LS+P D+ + NN Sbjct: 419 LIGCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINNR--P 476 Query: 461 SPSEQGSNSTYDRIFPLRPDYQEPSRLIRKLPEFAP----GEEESGCSGVVKPVQPSGP- 515 P E P YQEP R P AP G SG ++P +P P Sbjct: 477 GPREP-------------PPYQEP-RPRGNPPHSAPCVPNGSAYSG--DYMEPEKPGAPL 520 Query: 516 ------EGVPHYAEADIVNLQGVTGGNTYSVPAVTMDLLSGKDVAVEEFPRKLLTFKEKL 569 VPHYAEADIV LQGVTGGNTY+VPA+ + V+ FPR L FKEKL Sbjct: 521 LPPPPQNSVPHYAEADIVTLQGVTGGNTYAVPALPPGAVGDGPPRVD-FPRSRLRFKEKL 579 Query: 570 GEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIM 629 GEGQFGEVHLCEV+ + DF L+V P+LVAVK+LR DA KNARNDFLKE+KIM Sbjct: 580 GEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIM 639 Query: 630 SRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHE---------PPNSSSSDVR 680 SRLKDPNII LL VC+ DDPLCMIT+YMENGDLNQFLS H+ P + ++ Sbjct: 640 SRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGP 699 Query: 681 TVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDY 740 T+SY L +A QIASGM+YL++LNFVHRDLATRNCLVG+N+TIKIADFGMSRNLY+GDY Sbjct: 700 TISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDY 759 Query: 741 YRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIEN 800 YR+QGRAVLPIRWM+WE IL+GKFTTASDVWAFGVTLWE C+ QP+ QL+DEQVIEN Sbjct: 760 YRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIEN 819 Query: 801 TGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLLLLQ 851 GEFFRDQGRQ YL +P CP +Y+LML CW R+++ RP F ++H L + Sbjct: 820 AGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAE 870 >gi|83977450 discoidin domain receptor family, member 1 isoform a [Homo sapiens] Length = 913 Score = 912 bits (2356), Expect = 0.0 Identities = 480/910 (52%), Positives = 598/910 (65%), Gaps = 68/910 (7%) Query: 5 PRMLLVLFLLLPILSS---AKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKYG 61 P L L LLL + S K +PA CRY LGM IPD DI+ASS WS+STAA++ Sbjct: 3 PEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAARHS 62 Query: 62 RLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKIN 121 RL+S +GDGAWCP V P + +E+LQ+DL LH + LVGTQGRHAGG G EF+ Y++ Sbjct: 63 RLESSDGDGAWCPAGSVFPKE-EEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRLR 121 Query: 122 YSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRVE 181 YSRDG RW+ W++R G++V+ GN +P + LKDL PP+VAR VRF P D M+VC+RVE Sbjct: 122 YSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRVE 181 Query: 182 LYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDG-AVGYSMTEGLGQLTDGVSGLD 240 LYGC+W DGL+SY AP GQ L +YLNDS YDG VG GLGQL DGV GLD Sbjct: 182 LYGCLWRDGLLSYTAPVGQTMYL--SEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLD 239 Query: 241 DFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFK 300 DF ++ E VWPGYDYVGW N S ++GY+E+ FEFDR+R F M+VHCNNM G ++ Sbjct: 240 DFRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPG 299 Query: 301 EVQCYFR-SEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMF 359 V+C FR A WE + L + +P AR V+VPL R+A ++C++ FA W++F Sbjct: 300 GVECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLF 359 Query: 360 SEITFQSDAAMYNNSEAL----PTSP---------------MAPTTYDPMLKVDDSNTRI 400 SEI+F SD + N+S AL P +P + P P+ K + S T I Sbjct: 360 SEISFISDV-VNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTAI 418 Query: 401 LIGCLVAIIFILLAIIVIILWRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNN--- 457 LIGCLVAII +LL II ++LWR W+++L KA RR+L++E+TV LS+P D+ + NN Sbjct: 419 LIGCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINNRPGP 478 Query: 458 -----------RSSSPSEQGSNSTYDRIFPLRPDYQ--------EPSRLIRKLPEFAPGE 498 R + P + P Y+ P P +A Sbjct: 479 REPPPYQEPRPRGNPPHSAPCVPNGSALLLSNPAYRLLLATYARPPRGPGPPTPAWAKPT 538 Query: 499 EESGCSG-VVKPVQPSGP-------EGVPHYAEADIVNLQGVTGGNTYSVPAVTMDLLSG 550 SG ++P +P P VPHYAEADIV LQGVTGGNTY+VPA+ + Sbjct: 539 NTQAYSGDYMEPEKPGAPLLPPPPQNSVPHYAEADIVTLQGVTGGNTYAVPALPPGAVGD 598 Query: 551 KDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKML 610 V+ FPR L FKEKLGEGQFGEVHLCEV+ + DF L+V P+LVAVK+L Sbjct: 599 GPPRVD-FPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKIL 657 Query: 611 RADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHE 670 R DA KNARNDFLKE+KIMSRLKDPNII LL VC+ DDPLCMIT+YMENGDLNQFLS H+ Sbjct: 658 RPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQ 717 Query: 671 ---------PPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKN 721 P + ++ T+SY L +A QIASGM+YL++LNFVHRDLATRNCLVG+N Sbjct: 718 LEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGEN 777 Query: 722 YTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETF 781 +TIKIADFGMSRNLY+GDYYR+QGRAVLPIRWM+WE IL+GKFTTASDVWAFGVTLWE Sbjct: 778 FTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVL 837 Query: 782 TFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPS 841 C+ QP+ QL+DEQVIEN GEFFRDQGRQ YL +P CP +Y+LML CW R+++ RP Sbjct: 838 MLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPP 897 Query: 842 FQEIHLLLLQ 851 F ++H L + Sbjct: 898 FSQLHRFLAE 907 >gi|83977452 discoidin domain receptor family, member 1 isoform c [Homo sapiens] Length = 919 Score = 905 bits (2339), Expect = 0.0 Identities = 480/916 (52%), Positives = 598/916 (65%), Gaps = 74/916 (8%) Query: 5 PRMLLVLFLLLPILSS---AKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKYG 61 P L L LLL + S K +PA CRY LGM IPD DI+ASS WS+STAA++ Sbjct: 3 PEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAARHS 62 Query: 62 RLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKIN 121 RL+S +GDGAWCP V P + +E+LQ+DL LH + LVGTQGRHAGG G EF+ Y++ Sbjct: 63 RLESSDGDGAWCPAGSVFPKE-EEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRLR 121 Query: 122 YSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRVE 181 YSRDG RW+ W++R G++V+ GN +P + LKDL PP+VAR VRF P D M+VC+RVE Sbjct: 122 YSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRVE 181 Query: 182 LYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDG-AVGYSMTEGLGQLTDGVSGLD 240 LYGC+W DGL+SY AP GQ L +YLNDS YDG VG GLGQL DGV GLD Sbjct: 182 LYGCLWRDGLLSYTAPVGQTMYL--SEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLD 239 Query: 241 DFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFK 300 DF ++ E VWPGYDYVGW N S ++GY+E+ FEFDR+R F M+VHCNNM G ++ Sbjct: 240 DFRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPG 299 Query: 301 EVQCYFR-SEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMF 359 V+C FR A WE + L + +P AR V+VPL R+A ++C++ FA W++F Sbjct: 300 GVECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLF 359 Query: 360 SEITFQSDAAMYNNSEAL----PTSP---------------MAPTTYDPMLKVDDSNTRI 400 SEI+F SD + N+S AL P +P + P P+ K + S T I Sbjct: 360 SEISFISDV-VNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTAI 418 Query: 401 LIGCLVAIIFILLAIIVIILWRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNN--- 457 LIGCLVAII +LL II ++LWR W+++L KA RR+L++E+TV LS+P D+ + NN Sbjct: 419 LIGCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINNRPGP 478 Query: 458 -----------RSSSPSEQGSNSTYDRIFPLRPDYQ--------EPSRLIRKLPEFAPGE 498 R + P + P Y+ P P +A Sbjct: 479 REPPPYQEPRPRGNPPHSAPCVPNGSALLLSNPAYRLLLATYARPPRGPGPPTPAWAKPT 538 Query: 499 EESGCSG-VVKPVQPSGP-------EGVPHYAEADIVNLQGVTGGNTYSVPAVTMDLLSG 550 SG ++P +P P VPHYAEADIV LQGVTGGNTY+VPA+ + Sbjct: 539 NTQAYSGDYMEPEKPGAPLLPPPPQNSVPHYAEADIVTLQGVTGGNTYAVPALPPGAVGD 598 Query: 551 KDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKML 610 V+ FPR L FKEKLGEGQFGEVHLCEV+ + DF L+V P+LVAVK+L Sbjct: 599 GPPRVD-FPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKIL 657 Query: 611 RADANKNA------RNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQ 664 R DA KNA RNDFLKE+KIMSRLKDPNII LL VC+ DDPLCMIT+YMENGDLNQ Sbjct: 658 RPDATKNASFSLFSRNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQ 717 Query: 665 FLSRHE---------PPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRN 715 FLS H+ P + ++ T+SY L +A QIASGM+YL++LNFVHRDLATRN Sbjct: 718 FLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRN 777 Query: 716 CLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGV 775 CLVG+N+TIKIADFGMSRNLY+GDYYR+QGRAVLPIRWM+WE IL+GKFTTASDVWAFGV Sbjct: 778 CLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGV 837 Query: 776 TLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRD 835 TLWE C+ QP+ QL+DEQVIEN GEFFRDQGRQ YL +P CP +Y+LML CW R+ Sbjct: 838 TLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRE 897 Query: 836 TKNRPSFQEIHLLLLQ 851 ++ RP F ++H L + Sbjct: 898 SEQRPPFSQLHRFLAE 913 >gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isoform c precursor [Homo sapiens] Length = 822 Score = 253 bits (647), Expect = 4e-67 Identities = 148/341 (43%), Positives = 204/341 (59%), Gaps = 27/341 (7%) Query: 512 PSGPEGVPHYAEADIVNLQGVTGGNTYSVPAVTMDLLSGKDVAVEEFPRKLLTFKEKLGE 571 PS EG P +A I+ + + +T L D V+ R + K +LGE Sbjct: 491 PSSSEGGP---DAVIIGMTKIPVIENPQYFGITNSQLK-PDTFVQHIKRHNIVLKRELGE 546 Query: 572 GQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSR 631 G FG+V L E + +DK +LVAVK L+ DA+ NAR DF +E ++++ Sbjct: 547 GAFGKVFLAECYNLCPEQDK-----------ILVAVKTLK-DASDNARKDFHREAELLTN 594 Query: 632 LKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPN---SSSSDVRTVSYTNLK 688 L+ +I+ VC+ DPL M+ EYM++GDLN+FL H P + + ++ + + Sbjct: 595 LQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQML 654 Query: 689 FMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAV 748 +A QIA+GM YL+S +FVHRDLATRNCLVG+N +KI DFGMSR++YS DYYR+ G + Sbjct: 655 HIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTM 714 Query: 749 LPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQ 808 LPIRWM ESI+ KFTT SDVW+ GV LWE FT+ +QP+ QLS+ +VIE Q Sbjct: 715 LPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTY-GKQPWYQLSNNEVIECI-----TQ 768 Query: 809 GRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLLL 849 GR L +P CP VY+LML CW+R+ R + + IH LL Sbjct: 769 GR--VLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLL 807 >gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isoform a precursor [Homo sapiens] Length = 838 Score = 253 bits (647), Expect = 4e-67 Identities = 148/341 (43%), Positives = 204/341 (59%), Gaps = 27/341 (7%) Query: 512 PSGPEGVPHYAEADIVNLQGVTGGNTYSVPAVTMDLLSGKDVAVEEFPRKLLTFKEKLGE 571 PS EG P +A I+ + + +T L D V+ R + K +LGE Sbjct: 507 PSSSEGGP---DAVIIGMTKIPVIENPQYFGITNSQLK-PDTFVQHIKRHNIVLKRELGE 562 Query: 572 GQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSR 631 G FG+V L E + +DK +LVAVK L+ DA+ NAR DF +E ++++ Sbjct: 563 GAFGKVFLAECYNLCPEQDK-----------ILVAVKTLK-DASDNARKDFHREAELLTN 610 Query: 632 LKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPN---SSSSDVRTVSYTNLK 688 L+ +I+ VC+ DPL M+ EYM++GDLN+FL H P + + ++ + + Sbjct: 611 LQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQML 670 Query: 689 FMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAV 748 +A QIA+GM YL+S +FVHRDLATRNCLVG+N +KI DFGMSR++YS DYYR+ G + Sbjct: 671 HIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTM 730 Query: 749 LPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQ 808 LPIRWM ESI+ KFTT SDVW+ GV LWE FT+ +QP+ QLS+ +VIE Q Sbjct: 731 LPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTY-GKQPWYQLSNNEVIECI-----TQ 784 Query: 809 GRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLLL 849 GR L +P CP VY+LML CW+R+ R + + IH LL Sbjct: 785 GR--VLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLL 823 >gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isoform b precursor [Homo sapiens] Length = 825 Score = 248 bits (633), Expect = 2e-65 Identities = 139/304 (45%), Positives = 189/304 (62%), Gaps = 26/304 (8%) Query: 552 DVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLR 611 D V+ R+ + K +LGEG FG+V L E + KDK +LVAVK L+ Sbjct: 527 DTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDK-----------MLVAVKALK 575 Query: 612 ADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEP 671 D AR DF +E ++++ L+ +I+ VC DPL M+ EYM++GDLN+FL H P Sbjct: 576 -DPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGP 634 Query: 672 PNSSSSDVRT------VSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIK 725 D + + + + +A+QIASGM YL+S +FVHRDLATRNCLVG N +K Sbjct: 635 DAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVK 694 Query: 726 IADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQ 785 I DFGMSR++YS DYYR+ G +LPIRWM ESI+ KFTT SDVW+FGV LWE FT+ Sbjct: 695 IGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTY-G 753 Query: 786 EQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEI 845 +QP+ QLS+ +VIE QGR L +P +CP VY +ML CW+R+ + R + +EI Sbjct: 754 KQPWFQLSNTEVIECI-----TQGR--VLERPRVCPKEVYDVMLGCWQREPQQRLNIKEI 806 Query: 846 HLLL 849 + +L Sbjct: 807 YKIL 810 >gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isoform 1 [Homo sapiens] Length = 790 Score = 244 bits (622), Expect = 3e-64 Identities = 135/303 (44%), Positives = 188/303 (62%), Gaps = 25/303 (8%) Query: 552 DVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLR 611 D V R+ + K +LGEG FG+V L E + +DK +LVAVK L+ Sbjct: 493 DACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDK-----------MLVAVKALK 541 Query: 612 ADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEP 671 +A+++AR DF +E ++++ L+ +I+ VC PL M+ EYM +GDLN+FL H P Sbjct: 542 -EASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP 600 Query: 672 PN---SSSSDVRT--VSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKI 726 + DV + L +A+Q+A+GM YL+ L+FVHRDLATRNCLVG+ +KI Sbjct: 601 DAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKI 660 Query: 727 ADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQE 786 DFGMSR++YS DYYR+ GR +LPIRWM ESIL KFTT SDVW+FGV LWE FT+ + Sbjct: 661 GDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTY-GK 719 Query: 787 QPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIH 846 QP+ QLS+ + I+ QGR+ L +P CP VY +M CW+R+ + R S +++H Sbjct: 720 QPWYQLSNTEAIDCI-----TQGRE--LERPRACPPEVYAIMRGCWQREPQQRHSIKDVH 772 Query: 847 LLL 849 L Sbjct: 773 ARL 775 >gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isoform 2 [Homo sapiens] Length = 796 Score = 244 bits (622), Expect = 3e-64 Identities = 135/303 (44%), Positives = 188/303 (62%), Gaps = 25/303 (8%) Query: 552 DVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLR 611 D V R+ + K +LGEG FG+V L E + +DK +LVAVK L+ Sbjct: 499 DACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDK-----------MLVAVKALK 547 Query: 612 ADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEP 671 +A+++AR DF +E ++++ L+ +I+ VC PL M+ EYM +GDLN+FL H P Sbjct: 548 -EASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP 606 Query: 672 PN---SSSSDVRT--VSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKI 726 + DV + L +A+Q+A+GM YL+ L+FVHRDLATRNCLVG+ +KI Sbjct: 607 DAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKI 666 Query: 727 ADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQE 786 DFGMSR++YS DYYR+ GR +LPIRWM ESIL KFTT SDVW+FGV LWE FT+ + Sbjct: 667 GDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTY-GK 725 Query: 787 QPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIH 846 QP+ QLS+ + I+ QGR+ L +P CP VY +M CW+R+ + R S +++H Sbjct: 726 QPWYQLSNTEAIDCI-----TQGRE--LERPRACPPEVYAIMRGCWQREPQQRHSIKDVH 778 Query: 847 LLL 849 L Sbjct: 779 ARL 781 >gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isoform 3 [Homo sapiens] Length = 760 Score = 244 bits (622), Expect = 3e-64 Identities = 135/303 (44%), Positives = 188/303 (62%), Gaps = 25/303 (8%) Query: 552 DVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLR 611 D V R+ + K +LGEG FG+V L E + +DK +LVAVK L+ Sbjct: 463 DACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDK-----------MLVAVKALK 511 Query: 612 ADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEP 671 +A+++AR DF +E ++++ L+ +I+ VC PL M+ EYM +GDLN+FL H P Sbjct: 512 -EASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP 570 Query: 672 PN---SSSSDVRT--VSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKI 726 + DV + L +A+Q+A+GM YL+ L+FVHRDLATRNCLVG+ +KI Sbjct: 571 DAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKI 630 Query: 727 ADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQE 786 DFGMSR++YS DYYR+ GR +LPIRWM ESIL KFTT SDVW+FGV LWE FT+ + Sbjct: 631 GDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTY-GK 689 Query: 787 QPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIH 846 QP+ QLS+ + I+ QGR+ L +P CP VY +M CW+R+ + R S +++H Sbjct: 690 QPWYQLSNTEAIDCI-----TQGRE--LERPRACPPEVYAIMRGCWQREPQQRHSIKDVH 742 Query: 847 LLL 849 L Sbjct: 743 ARL 745 >gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isoform a precursor [Homo sapiens] Length = 839 Score = 238 bits (608), Expect = 1e-62 Identities = 139/318 (43%), Positives = 189/318 (59%), Gaps = 40/318 (12%) Query: 552 DVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLR 611 D V+ R+ + K +LGEG FG+V L E + KDK +LVAVK L+ Sbjct: 527 DTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDK-----------MLVAVKALK 575 Query: 612 ADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEP 671 D AR DF +E ++++ L+ +I+ VC DPL M+ EYM++GDLN+FL H P Sbjct: 576 -DPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGP 634 Query: 672 PNSSSSDVRT------VSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIK 725 D + + + + +A+QIASGM YL+S +FVHRDLATRNCLVG N +K Sbjct: 635 DAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVK 694 Query: 726 IADFGMSRNLYSGDYYR--------------IQGRAVLPIRWMSWESILLGKFTTASDVW 771 I DFGMSR++YS DYYR + G +LPIRWM ESI+ KFTT SDVW Sbjct: 695 IGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVW 754 Query: 772 AFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSC 831 +FGV LWE FT+ +QP+ QLS+ +VIE QGR L +P +CP VY +ML C Sbjct: 755 SFGVILWEIFTY-GKQPWFQLSNTEVIECI-----TQGR--VLERPRVCPKEVYDVMLGC 806 Query: 832 WRRDTKNRPSFQEIHLLL 849 W+R+ + R + +EI+ +L Sbjct: 807 WQREPQQRLNIKEIYKIL 824 >gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens] Length = 869 Score = 226 bits (576), Expect = 7e-59 Identities = 130/319 (40%), Positives = 178/319 (55%), Gaps = 33/319 (10%) Query: 545 MDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVL 604 M LL + E+PR + + +GEG FG V G+ ++ + Sbjct: 557 MPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPF-----------TM 605 Query: 605 VAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQ 664 VAVKML+ +A+ + + DF +E +M+ +PNI+ LL VC P+C++ EYM GDLN+ Sbjct: 606 VAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNE 665 Query: 665 FL---SRHEPPNSSSSDVRT-----------VSYTNLKFMATQIASGMKYLSSLNFVHRD 710 FL S H + S SD+ +S +A Q+A+GM YLS FVHRD Sbjct: 666 FLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRD 725 Query: 711 LATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDV 770 LATRNCLVG+N +KIADFG+SRN+YS DYY+ +PIRWM ESI ++TT SDV Sbjct: 726 LATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDV 785 Query: 771 WAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLS 830 WA+GV LWE F++ QPY ++ E+VI + RD L P CP +Y LM Sbjct: 786 WAYGVVLWEIFSY-GLQPYYGMAHEEVI----YYVRD---GNILSCPENCPVELYNLMRL 837 Query: 831 CWRRDTKNRPSFQEIHLLL 849 CW + +RPSF IH +L Sbjct: 838 CWSKLPADRPSFTSIHRIL 856 >gi|4557665 insulin-like growth factor 1 receptor precursor [Homo sapiens] Length = 1367 Score = 212 bits (539), Expect = 1e-54 Identities = 126/314 (40%), Positives = 174/314 (55%), Gaps = 22/314 (7%) Query: 535 GNTYSVPAVTMDLLSGKDVAVE---EFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDK 591 GN +V + S DV V E R+ +T +LG+G FG V+ EG+ K K Sbjct: 968 GNGVLYASVNPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVY----EGVAKGVVK 1023 Query: 592 DFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLC 651 D VA+K + A+ R +FL E +M +++ LL V P Sbjct: 1024 D-------EPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTL 1076 Query: 652 MITEYMENGDLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDL 711 +I E M GDL +L P ++ + S + + MA +IA GM YL++ FVHRDL Sbjct: 1077 VIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDL 1136 Query: 712 ATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVW 771 A RNC+V +++T+KI DFGM+R++Y DYYR G+ +LP+RWMS ES+ G FTT SDVW Sbjct: 1137 AARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVW 1196 Query: 772 AFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSC 831 +FGV LWE T EQPY LS+EQV+ F + G L +P CPD +++LM C Sbjct: 1197 SFGVVLWEIATLA-EQPYQGLSNEQVL----RFVMEGG---LLDKPDNCPDMLFELMRMC 1248 Query: 832 WRRDTKNRPSFQEI 845 W+ + K RPSF EI Sbjct: 1249 WQYNPKMRPSFLEI 1262 >gi|134152725 receptor tyrosine kinase-like orphan receptor 1 isoform 1 [Homo sapiens] Length = 937 Score = 211 bits (536), Expect = 3e-54 Identities = 120/301 (39%), Positives = 173/301 (57%), Gaps = 27/301 (8%) Query: 556 EEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADAN 615 +E P + F E+LGE FG+++ +G D A LVA+K L+ N Sbjct: 466 KELPLSAVRFMEELGECAFGKIY----KGHLYLPGMDHAQ--------LVAIKTLKDYNN 513 Query: 616 KNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFL---SRHEPP 672 +F +E +M+ L PNI+ LL + P+CM+ EY+ GDL++FL S H Sbjct: 514 PQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDV 573 Query: 673 NSSSSDVRTVS----YTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIAD 728 SS + TV + + +A QIA+GM+YLSS FVH+DLA RN L+G+ +KI+D Sbjct: 574 GCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISD 633 Query: 729 FGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQP 788 G+SR +YS DYYR+Q +++LPIRWM E+I+ GKF++ SD+W+FGV LWE F+F QP Sbjct: 634 LGLSREIYSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSF-GLQP 692 Query: 789 YSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLL 848 Y S+++VIE ++ LP CP +Y LM CW RP F++IH+ Sbjct: 693 YYGFSNQEVIEMV-------RKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVR 745 Query: 849 L 849 L Sbjct: 746 L 746 >gi|19743898 receptor tyrosine kinase-like orphan receptor 2 precursor [Homo sapiens] Length = 943 Score = 204 bits (520), Expect = 2e-52 Identities = 119/310 (38%), Positives = 172/310 (55%), Gaps = 25/310 (8%) Query: 551 KDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKML 610 K ++E + F E+LGE +FG+V+ + G Q VA+K L Sbjct: 461 KQAKLKEISLSAVRFMEELGEDRFGKVYKGHLFG-----------PAPGEQTQAVAIKTL 509 Query: 611 RADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHE 670 + A R +F E + +RL+ PN++ LL V D PL MI Y +GDL++FL Sbjct: 510 KDKAEGPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRS 569 Query: 671 PPNS--SSSDVRTVSYT----NLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTI 724 P + S+ D RTV + + QIA+GM+YLSS + VH+DLATRN LV + Sbjct: 570 PHSDVGSTDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNV 629 Query: 725 KIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFC 784 KI+D G+ R +Y+ DYY++ G ++LPIRWM+ E+I+ GKF+ SD+W++GV LWE F++ Sbjct: 630 KISDLGLFREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSY- 688 Query: 785 QEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQE 844 QPY S++ V+E + RQ LP P CP VY LM+ CW RP F++ Sbjct: 689 GLQPYCGYSNQDVVEMI------RNRQV-LPCPDDCPAWVYALMIECWNEFPSRRPRFKD 741 Query: 845 IHLLLLQQGD 854 IH L G+ Sbjct: 742 IHSRLRAWGN 751 >gi|119395738 insulin receptor isoform Short precursor [Homo sapiens] Length = 1370 Score = 202 bits (515), Expect = 8e-52 Identities = 128/339 (37%), Positives = 181/339 (53%), Gaps = 31/339 (9%) Query: 511 QPSGPEGVPHYAEADIVNLQGVTGGNTYSVPAVTMDLLSGKDVAVEEFPRKLLTFKEKLG 570 QP GP G P YA + N + ++ + + D E R+ +T +LG Sbjct: 971 QPDGPLG-PLYASS---NPEYLSASDVFPCSVYVPDEW--------EVSREKITLLRELG 1018 Query: 571 EGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMS 630 +G FG V+ EG +D + VAVK + A+ R +FL E +M Sbjct: 1019 QGSFGMVY----EG----NARDI---IKGEAETRVAVKTVNESASLRERIEFLNEASVMK 1067 Query: 631 RLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRTVSYTNLKFM 690 +++ LL V P ++ E M +GDL +L P ++ + + M Sbjct: 1068 GFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQM 1127 Query: 691 ATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLP 750 A +IA GM YL++ FVHRDLA RNC+V ++T+KI DFGM+R++Y DYYR G+ +LP Sbjct: 1128 AAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLP 1187 Query: 751 IRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGR 810 +RWM+ ES+ G FTT+SD+W+FGV LWE T EQPY LS+EQV+ +F D G Sbjct: 1188 VRWMAPESLKDGVFTTSSDMWSFGVVLWE-ITSLAEQPYQGLSNEQVL----KFVMDGG- 1241 Query: 811 QTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLLL 849 YL QP CP+ V LM CW+ + K RP+F EI LL Sbjct: 1242 --YLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL 1278 >gi|119395736 insulin receptor isoform Long precursor [Homo sapiens] Length = 1382 Score = 202 bits (515), Expect = 8e-52 Identities = 128/339 (37%), Positives = 181/339 (53%), Gaps = 31/339 (9%) Query: 511 QPSGPEGVPHYAEADIVNLQGVTGGNTYSVPAVTMDLLSGKDVAVEEFPRKLLTFKEKLG 570 QP GP G P YA + N + ++ + + D E R+ +T +LG Sbjct: 983 QPDGPLG-PLYASS---NPEYLSASDVFPCSVYVPDEW--------EVSREKITLLRELG 1030 Query: 571 EGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMS 630 +G FG V+ EG +D + VAVK + A+ R +FL E +M Sbjct: 1031 QGSFGMVY----EG----NARDI---IKGEAETRVAVKTVNESASLRERIEFLNEASVMK 1079 Query: 631 RLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRTVSYTNLKFM 690 +++ LL V P ++ E M +GDL +L P ++ + + M Sbjct: 1080 GFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQM 1139 Query: 691 ATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLP 750 A +IA GM YL++ FVHRDLA RNC+V ++T+KI DFGM+R++Y DYYR G+ +LP Sbjct: 1140 AAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLP 1199 Query: 751 IRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGR 810 +RWM+ ES+ G FTT+SD+W+FGV LWE T EQPY LS+EQV+ +F D G Sbjct: 1200 VRWMAPESLKDGVFTTSSDMWSFGVVLWE-ITSLAEQPYQGLSNEQVL----KFVMDGG- 1253 Query: 811 QTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLLL 849 YL QP CP+ V LM CW+ + K RP+F EI LL Sbjct: 1254 --YLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL 1290 >gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a [Homo sapiens] Length = 1130 Score = 201 bits (512), Expect = 2e-51 Identities = 119/290 (41%), Positives = 165/290 (56%), Gaps = 35/290 (12%) Query: 557 EFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANK 616 E R +T K KLG GQ+GEV+ EG+ K + VAVK L+ D + Sbjct: 236 EMERTDITMKHKLGGGQYGEVY----EGVWK------------KYSLTVAVKTLKEDTME 279 Query: 617 NARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSS 676 +FLKE +M +K PN++ LL VC + P +ITE+M G+L +L Sbjct: 280 V--EEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRE-------- 329 Query: 677 SDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLY 736 + + V+ L +MATQI+S M+YL NF+HRDLA RNCLVG+N+ +K+ADFG+SR L Sbjct: 330 CNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSR-LM 388 Query: 737 SGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQ 796 +GD Y A PI+W + ES+ KF+ SDVWAFGV LWE T+ PY + Q Sbjct: 389 TGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGM-SPYPGIDLSQ 447 Query: 797 VIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIH 846 V E + +R + +P CP+ VY+LM +CW+ + +RPSF EIH Sbjct: 448 VYELLEKDYR-------MERPEGCPEKVYELMRACWQWNPSDRPSFAEIH 490 >gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b [Homo sapiens] Length = 1149 Score = 201 bits (512), Expect = 2e-51 Identities = 119/290 (41%), Positives = 165/290 (56%), Gaps = 35/290 (12%) Query: 557 EFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANK 616 E R +T K KLG GQ+GEV+ EG+ K + VAVK L+ D + Sbjct: 255 EMERTDITMKHKLGGGQYGEVY----EGVWK------------KYSLTVAVKTLKEDTME 298 Query: 617 NARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSS 676 +FLKE +M +K PN++ LL VC + P +ITE+M G+L +L Sbjct: 299 V--EEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRE-------- 348 Query: 677 SDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLY 736 + + V+ L +MATQI+S M+YL NF+HRDLA RNCLVG+N+ +K+ADFG+SR L Sbjct: 349 CNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSR-LM 407 Query: 737 SGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQ 796 +GD Y A PI+W + ES+ KF+ SDVWAFGV LWE T+ PY + Q Sbjct: 408 TGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGM-SPYPGIDLSQ 466 Query: 797 VIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIH 846 V E + +R + +P CP+ VY+LM +CW+ + +RPSF EIH Sbjct: 467 VYELLEKDYR-------MERPEGCPEKVYELMRACWQWNPSDRPSFAEIH 509 >gi|21361241 ephrin receptor EphA3 isoform a precursor [Homo sapiens] Length = 983 Score = 198 bits (503), Expect = 2e-50 Identities = 118/302 (39%), Positives = 168/302 (55%), Gaps = 37/302 (12%) Query: 554 AVEEFPRKL----LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKM 609 AV EF ++L ++ + +G G+FGEV G K K + + VA+K Sbjct: 608 AVHEFAKELDATNISIDKVVGAGEFGEV----CSGRLKLPSK---------KEISVAIKT 654 Query: 610 LRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRH 669 L+ + R DFL E IM + PNII L V P+ ++TEYMENG L+ FL +H Sbjct: 655 LKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKH 714 Query: 670 EPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADF 729 + + L M IASGMKYLS + +VHRDLA RN L+ N K++DF Sbjct: 715 D---------AQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDF 765 Query: 730 GMSRNLYSGD--YYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQ 787 G+SR L Y +G +PIRW S E+I KFT+ASDVW++G+ LWE ++ E+ Sbjct: 766 GLSRVLEDDPEAAYTTRG-GKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSY-GER 823 Query: 788 PYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHL 847 PY ++S++ VI+ E +R LP P CP ++Y+LML CW++D NRP F++I Sbjct: 824 PYWEMSNQDVIKAVDEGYR-------LPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVS 876 Query: 848 LL 849 +L Sbjct: 877 IL 878 >gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] Length = 1167 Score = 196 bits (498), Expect = 8e-50 Identities = 115/290 (39%), Positives = 158/290 (54%), Gaps = 35/290 (12%) Query: 557 EFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANK 616 E R +T K KLG GQ+GEV++ V + VAVK L+ D + Sbjct: 267 EMERTDITMKHKLGGGQYGEVYV----------------GVWKKYSLTVAVKTLKEDTME 310 Query: 617 NARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSS 676 +FLKE +M +K PN++ LL VC + P ++TEYM G+L +L Sbjct: 311 V--EEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRE-------- 360 Query: 677 SDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLY 736 + V+ L +MATQI+S M+YL NF+HRDLA RNCLVG+N+ +K+ADFG+SR L Sbjct: 361 CNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR-LM 419 Query: 737 SGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQ 796 +GD Y A PI+W + ES+ F+ SDVWAFGV LWE T+ PY + Q Sbjct: 420 TGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGM-SPYPGIDLSQ 478 Query: 797 VIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIH 846 V + + +R + QP CP VY+LM +CW+ +RPSF E H Sbjct: 479 VYDLLEKGYR-------MEQPEGCPPKVYELMRACWKWSPADRPSFAETH 521 >gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] Length = 1182 Score = 196 bits (498), Expect = 8e-50 Identities = 115/290 (39%), Positives = 158/290 (54%), Gaps = 35/290 (12%) Query: 557 EFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANK 616 E R +T K KLG GQ+GEV++ V + VAVK L+ D + Sbjct: 282 EMERTDITMKHKLGGGQYGEVYV----------------GVWKKYSLTVAVKTLKEDTME 325 Query: 617 NARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSS 676 +FLKE +M +K PN++ LL VC + P ++TEYM G+L +L Sbjct: 326 V--EEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRE-------- 375 Query: 677 SDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLY 736 + V+ L +MATQI+S M+YL NF+HRDLA RNCLVG+N+ +K+ADFG+SR L Sbjct: 376 CNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR-LM 434 Query: 737 SGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQ 796 +GD Y A PI+W + ES+ F+ SDVWAFGV LWE T+ PY + Q Sbjct: 435 TGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGM-SPYPGIDLSQ 493 Query: 797 VIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIH 846 V + + +R + QP CP VY+LM +CW+ +RPSF E H Sbjct: 494 VYDLLEKGYR-------MEQPEGCPPKVYELMRACWKWSPADRPSFAETH 536 >gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] Length = 542 Score = 196 bits (498), Expect = 8e-50 Identities = 115/290 (39%), Positives = 158/290 (54%), Gaps = 35/290 (12%) Query: 557 EFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANK 616 E R +T K KLG GQ+GEV++ V + VAVK L+ D + Sbjct: 261 EMERTDITMKHKLGGGQYGEVYV----------------GVWKKYSLTVAVKTLKEDTME 304 Query: 617 NARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSS 676 +FLKE +M +K PN++ LL VC + P ++TEYM G+L +L Sbjct: 305 V--EEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRE-------- 354 Query: 677 SDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLY 736 + V+ L +MATQI+S M+YL NF+HRDLA RNCLVG+N+ +K+ADFG+SR L Sbjct: 355 CNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR-LM 413 Query: 737 SGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQ 796 +GD Y A PI+W + ES+ F+ SDVWAFGV LWE T+ PY + Q Sbjct: 414 TGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGM-SPYPGIDLSQ 472 Query: 797 VIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIH 846 V + + +R + QP CP VY+LM +CW+ +RPSF E H Sbjct: 473 VYDLLEKGYR-------MEQPEGCPPKVYELMRACWKWSPADRPSFAETH 515 >gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] Length = 1064 Score = 196 bits (498), Expect = 8e-50 Identities = 115/290 (39%), Positives = 158/290 (54%), Gaps = 35/290 (12%) Query: 557 EFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANK 616 E R +T K KLG GQ+GEV++ V + VAVK L+ D + Sbjct: 267 EMERTDITMKHKLGGGQYGEVYV----------------GVWKKYSLTVAVKTLKEDTME 310 Query: 617 NARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSS 676 +FLKE +M +K PN++ LL VC + P ++TEYM G+L +L Sbjct: 311 V--EEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRE-------- 360 Query: 677 SDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLY 736 + V+ L +MATQI+S M+YL NF+HRDLA RNCLVG+N+ +K+ADFG+SR L Sbjct: 361 CNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR-LM 419 Query: 737 SGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQ 796 +GD Y A PI+W + ES+ F+ SDVWAFGV LWE T+ PY + Q Sbjct: 420 TGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGM-SPYPGIDLSQ 478 Query: 797 VIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIH 846 V + + +R + QP CP VY+LM +CW+ +RPSF E H Sbjct: 479 VYDLLEKGYR-------MEQPEGCPPKVYELMRACWKWSPADRPSFAETH 521 >gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] Length = 1146 Score = 196 bits (498), Expect = 8e-50 Identities = 115/290 (39%), Positives = 158/290 (54%), Gaps = 35/290 (12%) Query: 557 EFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANK 616 E R +T K KLG GQ+GEV++ V + VAVK L+ D + Sbjct: 246 EMERTDITMKHKLGGGQYGEVYV----------------GVWKKYSLTVAVKTLKEDTME 289 Query: 617 NARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSS 676 +FLKE +M +K PN++ LL VC + P ++TEYM G+L +L Sbjct: 290 V--EEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRE-------- 339 Query: 677 SDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLY 736 + V+ L +MATQI+S M+YL NF+HRDLA RNCLVG+N+ +K+ADFG+SR L Sbjct: 340 CNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR-LM 398 Query: 737 SGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQ 796 +GD Y A PI+W + ES+ F+ SDVWAFGV LWE T+ PY + Q Sbjct: 399 TGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGM-SPYPGIDLSQ 457 Query: 797 VIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIH 846 V + + +R + QP CP VY+LM +CW+ +RPSF E H Sbjct: 458 VYDLLEKGYR-------MEQPEGCPPKVYELMRACWKWSPADRPSFAETH 500 >gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [Homo sapiens] Length = 1070 Score = 194 bits (494), Expect = 2e-49 Identities = 127/361 (35%), Positives = 193/361 (53%), Gaps = 35/361 (9%) Query: 485 SRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSVPAVT 544 ++ ++K PE E E G ++ QPS A+I +T + S PA T Sbjct: 732 AKRLQKQPEGEEPEMECLNGGPLQNGQPS----------AEIQEEVALT--SLGSGPAAT 779 Query: 545 MDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVL 604 S D FPR L LG+ +FGEV L + +G+E+ L Sbjct: 780 NKRHSTSDKM--HFPRSSLQPITTLGKSEFGEVFLAKAQGLEE-----------GVAETL 826 Query: 605 VAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQ 664 V VK L++ ++ + DF +E+++ +L N++ LL +C +P M+ EY++ GDL Q Sbjct: 827 VLVKSLQSK-DEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQ 885 Query: 665 FLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTI 724 FL R + +S + TQ+A GM++LS+ FVH+DLA RNCLV + Sbjct: 886 FL-RISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQV 944 Query: 725 KIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFC 784 K++ G+S+++Y+ +YY + +A +P+RWMS E+IL G F+T SDVWAFGV +WE FT Sbjct: 945 KVSALGLSKDVYNSEYYHFR-QAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTH- 1002 Query: 785 QEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQE 844 E P+ +D++V+ + Q + LPQP CP +Y+LM CW K+RPSF E Sbjct: 1003 GEMPHGGQADDEVLADL------QAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSE 1056 Query: 845 I 845 I Sbjct: 1057 I 1057 >gi|22902130 PTK7 protein tyrosine kinase 7 isoform d precursor [Homo sapiens] Length = 1014 Score = 194 bits (494), Expect = 2e-49 Identities = 127/361 (35%), Positives = 193/361 (53%), Gaps = 35/361 (9%) Query: 485 SRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSVPAVT 544 ++ ++K PE E E G ++ QPS A+I +T + S PA T Sbjct: 676 AKRLQKQPEGEEPEMECLNGGPLQNGQPS----------AEIQEEVALT--SLGSGPAAT 723 Query: 545 MDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVL 604 S D FPR L LG+ +FGEV L + +G+E+ L Sbjct: 724 NKRHSTSDKM--HFPRSSLQPITTLGKSEFGEVFLAKAQGLEE-----------GVAETL 770 Query: 605 VAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQ 664 V VK L++ ++ + DF +E+++ +L N++ LL +C +P M+ EY++ GDL Q Sbjct: 771 VLVKSLQSK-DEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQ 829 Query: 665 FLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTI 724 FL R + +S + TQ+A GM++LS+ FVH+DLA RNCLV + Sbjct: 830 FL-RISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQV 888 Query: 725 KIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFC 784 K++ G+S+++Y+ +YY + +A +P+RWMS E+IL G F+T SDVWAFGV +WE FT Sbjct: 889 KVSALGLSKDVYNSEYYHFR-QAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTH- 946 Query: 785 QEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQE 844 E P+ +D++V+ + Q + LPQP CP +Y+LM CW K+RPSF E Sbjct: 947 GEMPHGGQADDEVLADL------QAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSE 1000 Query: 845 I 845 I Sbjct: 1001 I 1001 >gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor [Homo sapiens] Length = 940 Score = 194 bits (494), Expect = 2e-49 Identities = 127/361 (35%), Positives = 193/361 (53%), Gaps = 35/361 (9%) Query: 485 SRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSVPAVT 544 ++ ++K PE E E G ++ QPS A+I +T + S PA T Sbjct: 602 AKRLQKQPEGEEPEMECLNGGPLQNGQPS----------AEIQEEVALT--SLGSGPAAT 649 Query: 545 MDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVL 604 S D FPR L LG+ +FGEV L + +G+E+ L Sbjct: 650 NKRHSTSDKM--HFPRSSLQPITTLGKSEFGEVFLAKAQGLEE-----------GVAETL 696 Query: 605 VAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQ 664 V VK L++ ++ + DF +E+++ +L N++ LL +C +P M+ EY++ GDL Q Sbjct: 697 VLVKSLQSK-DEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQ 755 Query: 665 FLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTI 724 FL R + +S + TQ+A GM++LS+ FVH+DLA RNCLV + Sbjct: 756 FL-RISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQV 814 Query: 725 KIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFC 784 K++ G+S+++Y+ +YY + +A +P+RWMS E+IL G F+T SDVWAFGV +WE FT Sbjct: 815 KVSALGLSKDVYNSEYYHFR-QAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTH- 872 Query: 785 QEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQE 844 E P+ +D++V+ + Q + LPQP CP +Y+LM CW K+RPSF E Sbjct: 873 GEMPHGGQADDEVLADL------QAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSE 926 Query: 845 I 845 I Sbjct: 927 I 927 >gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor [Homo sapiens] Length = 1030 Score = 194 bits (494), Expect = 2e-49 Identities = 127/361 (35%), Positives = 193/361 (53%), Gaps = 35/361 (9%) Query: 485 SRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSVPAVT 544 ++ ++K PE E E G ++ QPS A+I +T + S PA T Sbjct: 692 AKRLQKQPEGEEPEMECLNGGPLQNGQPS----------AEIQEEVALT--SLGSGPAAT 739 Query: 545 MDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVL 604 S D FPR L LG+ +FGEV L + +G+E+ L Sbjct: 740 NKRHSTSDKM--HFPRSSLQPITTLGKSEFGEVFLAKAQGLEE-----------GVAETL 786 Query: 605 VAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQ 664 V VK L++ ++ + DF +E+++ +L N++ LL +C +P M+ EY++ GDL Q Sbjct: 787 VLVKSLQSK-DEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQ 845 Query: 665 FLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTI 724 FL R + +S + TQ+A GM++LS+ FVH+DLA RNCLV + Sbjct: 846 FL-RISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQV 904 Query: 725 KIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFC 784 K++ G+S+++Y+ +YY + +A +P+RWMS E+IL G F+T SDVWAFGV +WE FT Sbjct: 905 KVSALGLSKDVYNSEYYHFR-QAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTH- 962 Query: 785 QEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQE 844 E P+ +D++V+ + Q + LPQP CP +Y+LM CW K+RPSF E Sbjct: 963 GEMPHGGQADDEVLADL------QAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSE 1016 Query: 845 I 845 I Sbjct: 1017 I 1017 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.321 0.137 0.421 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 34,016,046 Number of Sequences: 37866 Number of extensions: 1587813 Number of successful extensions: 5923 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 582 Number of HSP's successfully gapped in prelim test: 197 Number of HSP's that attempted gapping in prelim test: 3870 Number of HSP's gapped (non-prelim): 991 length of query: 855 length of database: 18,247,518 effective HSP length: 111 effective length of query: 744 effective length of database: 14,044,392 effective search space: 10449027648 effective search space used: 10449027648 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.