Search of human proteins with 62362414

Search of human proteins with 62362414

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform
a [Homo sapiens]
         (1130 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a...  2272   0.0  
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b...  2221   0.0  
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]            1082   0.0  
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]            1080   0.0  
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]              1080   0.0  
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]             977   0.0  
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]             884   0.0  
gi|4503787 fyn-related kinase [Homo sapiens]                          380   e-105
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]              369   e-102
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]       365   e-100
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa...   364   e-100
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa...   364   e-100
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi...   364   e-100
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap...   363   e-100
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi...   363   e-100
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]      362   e-100
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs...   359   9e-99
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs...   359   9e-99
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]     358   2e-98
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ...   350   3e-96
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is...   348   1e-95
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]   340   3e-93
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]                 340   4e-93
gi|130977759 tec protein tyrosine kinase [Homo sapiens]               337   3e-92
gi|148596974 TXK tyrosine kinase [Homo sapiens]                       333   5e-91
gi|18250298 src-related kinase lacking C-terminal regulatory tyr...   312   1e-84
gi|187475373 c-src tyrosine kinase [Homo sapiens]                     312   1e-84
gi|4758078 c-src tyrosine kinase [Homo sapiens]                       312   1e-84
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]                309   8e-84
gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]      303   8e-82

>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
            [Homo sapiens]
          Length = 1130

 Score = 2272 bits (5887), Expect = 0.0
 Identities = 1130/1130 (100%), Positives = 1130/1130 (100%)

Query: 1    MLEICLKLVGCKSKKGLSSSSSCYLEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSE 60
            MLEICLKLVGCKSKKGLSSSSSCYLEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSE
Sbjct: 1    MLEICLKLVGCKSKKGLSSSSSCYLEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSE 60

Query: 61   NDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVN 120
            NDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVN
Sbjct: 61   NDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVN 120

Query: 121  SLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS 180
            SLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS
Sbjct: 121  SLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS 180

Query: 181  DGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERT 240
            DGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERT
Sbjct: 181  DGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERT 240

Query: 241  DITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ 300
            DITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ
Sbjct: 241  DITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ 300

Query: 301  LLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFI 360
            LLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFI
Sbjct: 301  LLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFI 360

Query: 361  HRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKS 420
            HRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKS
Sbjct: 361  HRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKS 420

Query: 421  DVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNP 480
            DVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNP
Sbjct: 421  DVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNP 480

Query: 481  SDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAE 540
            SDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAE
Sbjct: 481  SDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAE 540

Query: 541  HRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLF 600
            HRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLF
Sbjct: 541  HRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLF 600

Query: 601  SALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSP 660
            SALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSP
Sbjct: 601  SALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSP 660

Query: 661  KPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSAS 720
            KPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSAS
Sbjct: 661  KPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSAS 720

Query: 721  CVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTV 780
            CVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTV
Sbjct: 721  CVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTV 780

Query: 781  TPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGS 840
            TPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGS
Sbjct: 781  TPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGS 840

Query: 841  ALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPP 900
            ALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPP
Sbjct: 841  ALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPP 900

Query: 901  PPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVL 960
            PPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVL
Sbjct: 901  PPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVL 960

Query: 961  PATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPE 1020
            PATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPE
Sbjct: 961  PATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPE 1020

Query: 1021 RIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNK 1080
            RIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNK
Sbjct: 1021 RIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNK 1080

Query: 1081 FAFREAINKLENNLRELQICPATAGSGPAATQDFSKLLSSVKEISDIVQR 1130
            FAFREAINKLENNLRELQICPATAGSGPAATQDFSKLLSSVKEISDIVQR
Sbjct: 1081 FAFREAINKLENNLRELQICPATAGSGPAATQDFSKLLSSVKEISDIVQR 1130


>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
            [Homo sapiens]
          Length = 1149

 Score = 2221 bits (5754), Expect = 0.0
 Identities = 1104/1104 (100%), Positives = 1104/1104 (100%)

Query: 27   EALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGE 86
            EALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGE
Sbjct: 46   EALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGE 105

Query: 87   KLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGIN 146
            KLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGIN
Sbjct: 106  KLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGIN 165

Query: 147  GSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVA 206
            GSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVA
Sbjct: 166  GSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVA 225

Query: 207  DGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSL 266
            DGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSL
Sbjct: 226  DGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSL 285

Query: 267  TVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDY 326
            TVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDY
Sbjct: 286  TVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDY 345

Query: 327  LRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSR 386
            LRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSR
Sbjct: 346  LRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSR 405

Query: 387  LMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLS 446
            LMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLS
Sbjct: 406  LMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLS 465

Query: 447  QVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEV 506
            QVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEV
Sbjct: 466  QVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEV 525

Query: 507  EKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEP 566
            EKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEP
Sbjct: 526  EKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEP 585

Query: 567  AVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDG 626
            AVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDG
Sbjct: 586  AVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDG 645

Query: 627  QPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHL 686
            QPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHL
Sbjct: 646  QPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHL 705

Query: 687  WKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQ 746
            WKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQ
Sbjct: 706  WKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQ 765

Query: 747  FDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSP 806
            FDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSP
Sbjct: 766  FDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSP 825

Query: 807  GSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTS 866
            GSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTS
Sbjct: 826  GSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTS 885

Query: 867  KGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEA 926
            KGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEA
Sbjct: 886  KGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEA 945

Query: 927  VLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLP 986
            VLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLP
Sbjct: 946  VLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLP 1005

Query: 987  SASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISRN 1046
            SASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISRN
Sbjct: 1006 SASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISRN 1065

Query: 1047 SEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQICPATAGS 1106
            SEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQICPATAGS
Sbjct: 1066 SEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQICPATAGS 1125

Query: 1107 GPAATQDFSKLLSSVKEISDIVQR 1130
            GPAATQDFSKLLSSVKEISDIVQR
Sbjct: 1126 GPAATQDFSKLLSSVKEISDIVQR 1149


>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
          Length = 1146

 Score = 1082 bits (2798), Expect = 0.0
 Identities = 634/1174 (54%), Positives = 759/1174 (64%), Gaps = 117/1174 (9%)

Query: 18   SSSSSCYLEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGD 77
            S S+   L EAL RP   D EPQ L+EA RW+SKENLL G +E+DPNLFVALYDFVASGD
Sbjct: 29   SESALPDLTEALHRPYGCDVEPQALNEAIRWSSKENLL-GATESDPNLFVALYDFVASGD 87

Query: 78   NTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAA 137
            NTLSITKGEKLRVLGYN NGEW E ++KNGQGWVPSNYITPVNSLEKHSWYHGPVSR+AA
Sbjct: 88   NTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAA 147

Query: 138  EYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAE 197
            EYLLSS INGSFLVRESESSPGQ SISLRYEGRVYHYRINT +DGK+YV++ESRF+TLAE
Sbjct: 148  EYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAE 207

Query: 198  LVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVY 257
            LVHHHSTVADGL+TTLHYPAPK NKPTVYGVSP +DKWEMERTDITMKHKLGGGQYGEVY
Sbjct: 208  LVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVY 267

Query: 258  EGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEF 317
             GVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT EPPFYI+TE+
Sbjct: 268  VGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEY 327

Query: 318  MTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLV 377
            M YGNLLDYLRECNR+EV AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENH+V
Sbjct: 328  MPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVV 387

Query: 378  KVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGM 437
            KVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYN FSIKSDVWAFGVLLWEIATYGM
Sbjct: 388  KVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGM 447

Query: 438  SPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMF 497
            SPYPGIDLSQVY+LLEK YRME+PEGCP KVYELMRACW+W+P+DRPSFAE HQAFETMF
Sbjct: 448  SPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMF 507

Query: 498  QESSISDEVEKELGKQGVRGAVSTLL-QAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQ 556
             +SSIS+EV +ELG+     +V   L + P LP+KTRT ++  E+++  +  +       
Sbjct: 508  HDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSA 567

Query: 557  GESDP----LDHEPAVSPLLPRKERGPPEGGLNED--ERLLPKDKKTNLFSALIKKKKKT 610
                P         + SP LPRK+R      L ED  E    +D+K   FS+ +  KK+ 
Sbjct: 568  SSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFM--KKRN 625

Query: 611  APTPPKRSSSFREMDGQPERRGAGEEEGRDISNGAL------AFTPLDTADPAKSPKPSN 664
            APTPPKRSSSFREM+ QP ++   E  G   S  +L      +FTP         PK   
Sbjct: 626  APTPPKRSSSFREMENQPHKK--YELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYG 683

Query: 665  GAGVPNGALRESGG---------------SGFRSPHLWKKSSTLTSSRLATGEEEGGGSS 709
            G+        + GG               +GF +P L KK+  L +     G+      +
Sbjct: 684  GSFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRA-----GKPTASDDT 738

Query: 710  SKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGG--------------- 754
            SK F RS S S +  G  + +  ++TLPR+ Q +  Q + +                   
Sbjct: 739  SKPFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLP 798

Query: 755  HKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLT 814
             KSE+ A P +     ++  + RG    P R     + A  E      +  PG     + 
Sbjct: 799  KKSEESAAPSRE--RPKAKLLPRGATALPLR-TPSGDLAITE------KDPPGVGVAGVA 849

Query: 815  PKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTS---KAGSGAPGGTSKGPAE 871
              P  ++       G+    E G+     +PA A PV PT+   K            PA+
Sbjct: 850  AAPKGKEKNGGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPAD 909

Query: 872  ------ESRVRRHKHSSE---SPGRDKGKLSRLKP--APPPPPA---ASAGKAGGKPSQS 917
                  +S+  + K  SE   +   DK +  R+KP  APPPPP             P++ 
Sbjct: 910  VQLIGTDSQGNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEE 969

Query: 918  PSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPIS 977
            P+   AG++                      S+  EG KK  L A P    A   G P+ 
Sbjct: 970  PTALTAGQST---------------------SETQEGGKKAALGAVPISGKA---GRPVM 1005

Query: 978  PAP-VPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDST 1036
            P P VP  LP++S + A    + TA      T+V+LRKT+Q  E+I++  I+K  +L+  
Sbjct: 1006 PPPQVP--LPTSSISPA-KMANGTA-----GTKVALRKTKQAAEKISADKISKEALLECA 1057

Query: 1037 EALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRE 1096
            + L  A++    +   +S +++ G  L  +C  YVD I Q RNKFAFREA++KLE +L+E
Sbjct: 1058 DLLSSALT----EPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQE 1113

Query: 1097 LQICPATAGSGPAATQDFSKLLSSVKEISDIVQR 1130
            LQ+  A AG  P      + LLS V+EISD+VQR
Sbjct: 1114 LQVSSAAAGV-PGTNPVLNNLLSCVQEISDVVQR 1146


>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
          Length = 1167

 Score = 1080 bits (2794), Expect = 0.0
 Identities = 631/1165 (54%), Positives = 755/1165 (64%), Gaps = 117/1165 (10%)

Query: 27   EALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGE 86
            EAL RP   D EPQ L+EA RW+SKENLL G +E+DPNLFVALYDFVASGDNTLSITKGE
Sbjct: 59   EALHRPYGCDVEPQALNEAIRWSSKENLL-GATESDPNLFVALYDFVASGDNTLSITKGE 117

Query: 87   KLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGIN 146
            KLRVLGYN NGEW E ++KNGQGWVPSNYITPVNSLEKHSWYHGPVSR+AAEYLLSS IN
Sbjct: 118  KLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN 177

Query: 147  GSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVA 206
            GSFLVRESESSPGQ SISLRYEGRVYHYRINT +DGK+YV++ESRF+TLAELVHHHSTVA
Sbjct: 178  GSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVA 237

Query: 207  DGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSL 266
            DGL+TTLHYPAPK NKPTVYGVSP +DKWEMERTDITMKHKLGGGQYGEVY GVWKKYSL
Sbjct: 238  DGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSL 297

Query: 267  TVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDY 326
            TVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT EPPFYI+TE+M YGNLLDY
Sbjct: 298  TVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDY 357

Query: 327  LRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSR 386
            LRECNR+EV AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENH+VKVADFGLSR
Sbjct: 358  LRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR 417

Query: 387  LMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLS 446
            LMTGDTYTAHAGAKFPIKWTAPESLAYN FSIKSDVWAFGVLLWEIATYGMSPYPGIDLS
Sbjct: 418  LMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLS 477

Query: 447  QVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEV 506
            QVY+LLEK YRME+PEGCP KVYELMRACW+W+P+DRPSFAE HQAFETMF +SSIS+EV
Sbjct: 478  QVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEV 537

Query: 507  EKELGKQGVRGAVSTLL-QAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDP---- 561
             +ELG+     +V   L + P LP+KTRT ++  E+++  +  +           P    
Sbjct: 538  AEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIR 597

Query: 562  LDHEPAVSPLLPRKERGPPEGGLNED--ERLLPKDKKTNLFSALIKKKKKTAPTPPKRSS 619
                 + SP LPRK+R      L ED  E    +D+K   FS+ +  KK+ APTPPKRSS
Sbjct: 598  GAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFM--KKRNAPTPPKRSS 655

Query: 620  SFREMDGQPERRGAGEEEGRDISNGAL------AFTPLDTADPAKSPKPSNGAGVPNGAL 673
            SFREM+ QP ++   E  G   S  +L      +FTP         PK   G+       
Sbjct: 656  SFREMENQPHKK--YELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLC 713

Query: 674  RESGG---------------SGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCS 718
             + GG               +GF +P L KK+  L +     G+      +SK F RS S
Sbjct: 714  NDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRA-----GKPTASDDTSKPFPRSNS 768

Query: 719  ASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGG---------------HKSEKPALP 763
             S +  G  + +  ++TLPR+ Q +  Q + +                    KSE+ A P
Sbjct: 769  TSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAP 828

Query: 764  RKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVT 823
             +     ++  + RG    P R     + A  E      +  PG     +   P  ++  
Sbjct: 829  SRE--RPKAKLLPRGATALPLR-TPSGDLAITE------KDPPGVGVAGVAAAPKGKEKN 879

Query: 824  VAPASGLPHKEEAGKGSALGTPAAAEPVTPTS---KAGSGAPGGTSKGPAE------ESR 874
                 G+    E G+     +PA A PV PT+   K            PA+      +S+
Sbjct: 880  GGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQ 939

Query: 875  VRRHKHSSE---SPGRDKGKLSRLKP--APPPPPA---ASAGKAGGKPSQSPSQEAAGEA 926
              + K  SE   +   DK +  R+KP  APPPPP             P++ P+   AG++
Sbjct: 940  GNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQS 999

Query: 927  VLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAP-VPSTL 985
                                  S+  EG KK  L A P    A   G P+ P P VP  L
Sbjct: 1000 T---------------------SETQEGGKKAALGAVPISGKA---GRPVMPPPQVP--L 1033

Query: 986  PSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISR 1045
            P++S + A    + TA      T+V+LRKT+Q  E+I++  I+K  +L+  + L  A++ 
Sbjct: 1034 PTSSISPA-KMANGTA-----GTKVALRKTKQAAEKISADKISKEALLECADLLSSALT- 1086

Query: 1046 NSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQICPATAG 1105
               +   +S +++ G  L  +C  YVD I Q RNKFAFREA++KLE +L+ELQ+  A AG
Sbjct: 1087 ---EPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSAAAG 1143

Query: 1106 SGPAATQDFSKLLSSVKEISDIVQR 1130
              P      + LLS V+EISD+VQR
Sbjct: 1144 V-PGTNPVLNNLLSCVQEISDVVQR 1167


>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
          Length = 1182

 Score = 1080 bits (2794), Expect = 0.0
 Identities = 631/1165 (54%), Positives = 755/1165 (64%), Gaps = 117/1165 (10%)

Query: 27   EALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGE 86
            EAL RP   D EPQ L+EA RW+SKENLL G +E+DPNLFVALYDFVASGDNTLSITKGE
Sbjct: 74   EALHRPYGCDVEPQALNEAIRWSSKENLL-GATESDPNLFVALYDFVASGDNTLSITKGE 132

Query: 87   KLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGIN 146
            KLRVLGYN NGEW E ++KNGQGWVPSNYITPVNSLEKHSWYHGPVSR+AAEYLLSS IN
Sbjct: 133  KLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN 192

Query: 147  GSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVA 206
            GSFLVRESESSPGQ SISLRYEGRVYHYRINT +DGK+YV++ESRF+TLAELVHHHSTVA
Sbjct: 193  GSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVA 252

Query: 207  DGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSL 266
            DGL+TTLHYPAPK NKPTVYGVSP +DKWEMERTDITMKHKLGGGQYGEVY GVWKKYSL
Sbjct: 253  DGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSL 312

Query: 267  TVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDY 326
            TVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT EPPFYI+TE+M YGNLLDY
Sbjct: 313  TVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDY 372

Query: 327  LRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSR 386
            LRECNR+EV AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENH+VKVADFGLSR
Sbjct: 373  LRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR 432

Query: 387  LMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLS 446
            LMTGDTYTAHAGAKFPIKWTAPESLAYN FSIKSDVWAFGVLLWEIATYGMSPYPGIDLS
Sbjct: 433  LMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLS 492

Query: 447  QVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEV 506
            QVY+LLEK YRME+PEGCP KVYELMRACW+W+P+DRPSFAE HQAFETMF +SSIS+EV
Sbjct: 493  QVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEV 552

Query: 507  EKELGKQGVRGAVSTLL-QAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDP---- 561
             +ELG+     +V   L + P LP+KTRT ++  E+++  +  +           P    
Sbjct: 553  AEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIR 612

Query: 562  LDHEPAVSPLLPRKERGPPEGGLNED--ERLLPKDKKTNLFSALIKKKKKTAPTPPKRSS 619
                 + SP LPRK+R      L ED  E    +D+K   FS+ +  KK+ APTPPKRSS
Sbjct: 613  GAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFM--KKRNAPTPPKRSS 670

Query: 620  SFREMDGQPERRGAGEEEGRDISNGAL------AFTPLDTADPAKSPKPSNGAGVPNGAL 673
            SFREM+ QP ++   E  G   S  +L      +FTP         PK   G+       
Sbjct: 671  SFREMENQPHKK--YELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLC 728

Query: 674  RESGG---------------SGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCS 718
             + GG               +GF +P L KK+  L +     G+      +SK F RS S
Sbjct: 729  NDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRA-----GKPTASDDTSKPFPRSNS 783

Query: 719  ASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGG---------------HKSEKPALP 763
             S +  G  + +  ++TLPR+ Q +  Q + +                    KSE+ A P
Sbjct: 784  TSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAP 843

Query: 764  RKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVT 823
             +     ++  + RG    P R     + A  E      +  PG     +   P  ++  
Sbjct: 844  SRE--RPKAKLLPRGATALPLR-TPSGDLAITE------KDPPGVGVAGVAAAPKGKEKN 894

Query: 824  VAPASGLPHKEEAGKGSALGTPAAAEPVTPTS---KAGSGAPGGTSKGPAE------ESR 874
                 G+    E G+     +PA A PV PT+   K            PA+      +S+
Sbjct: 895  GGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQ 954

Query: 875  VRRHKHSSE---SPGRDKGKLSRLKP--APPPPPA---ASAGKAGGKPSQSPSQEAAGEA 926
              + K  SE   +   DK +  R+KP  APPPPP             P++ P+   AG++
Sbjct: 955  GNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQS 1014

Query: 927  VLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAP-VPSTL 985
                                  S+  EG KK  L A P    A   G P+ P P VP  L
Sbjct: 1015 T---------------------SETQEGGKKAALGAVPISGKA---GRPVMPPPQVP--L 1048

Query: 986  PSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISR 1045
            P++S + A    + TA      T+V+LRKT+Q  E+I++  I+K  +L+  + L  A++ 
Sbjct: 1049 PTSSISPA-KMANGTA-----GTKVALRKTKQAAEKISADKISKEALLECADLLSSALT- 1101

Query: 1046 NSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQICPATAG 1105
               +   +S +++ G  L  +C  YVD I Q RNKFAFREA++KLE +L+ELQ+  A AG
Sbjct: 1102 ---EPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSAAAG 1158

Query: 1106 SGPAATQDFSKLLSSVKEISDIVQR 1130
              P      + LLS V+EISD+VQR
Sbjct: 1159 V-PGTNPVLNNLLSCVQEISDVVQR 1182


>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
          Length = 1064

 Score =  977 bits (2526), Expect = 0.0
 Identities = 593/1137 (52%), Positives = 706/1137 (62%), Gaps = 164/1137 (14%)

Query: 27   EALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGE 86
            EAL RP   D EPQ L+EA RW+SKENLL G +E+DPNLFVALYDFVASGDNTLSITKGE
Sbjct: 59   EALHRPYGCDVEPQALNEAIRWSSKENLL-GATESDPNLFVALYDFVASGDNTLSITKGE 117

Query: 87   KLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGIN 146
            KLRVLGYN NGEW E ++KNGQGWVPSNYITPVNSLEKHSWYHGPVSR+AAEYLLSS IN
Sbjct: 118  KLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN 177

Query: 147  GSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVA 206
            GSFLVRESESSPGQ SISLRYEGRVYHYRINT +DGK+YV++ESRF+TLAELVHHHSTVA
Sbjct: 178  GSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVA 237

Query: 207  DGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSL 266
            DGL+TTLHYPAPK NKPTVYGVSP +DKWEMERTDITMKHKLGGGQYGEVY GVWKKYSL
Sbjct: 238  DGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSL 297

Query: 267  TVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDY 326
            TVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT EPPFYI+TE+M YGNLLDY
Sbjct: 298  TVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDY 357

Query: 327  LRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSR 386
            LRECNR+EV AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENH+VKVADFGLSR
Sbjct: 358  LRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR 417

Query: 387  LMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLS 446
            LMTGDTYTAHAGAKFPIKWTAPESLAYN FSIKSDVWAFGVLLWEIATYGMSPYPGIDLS
Sbjct: 418  LMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLS 477

Query: 447  QVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEV 506
            QVY+LLEK YRME+PEGCP KVYELMRACW+W+P+DRPSFAE HQAFETMF +SSIS   
Sbjct: 478  QVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSIS--- 534

Query: 507  EKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEP 566
             +E+ ++  R A S+ +                       VP +P               
Sbjct: 535  -EEVAEELGRAASSSSV-----------------------VPYLPRL------------- 557

Query: 567  AVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDG 626
               P+LP K R   +   N++     +D   N  S+L       AP              
Sbjct: 558  ---PILPSKTRTLKKQVENKENIEGAQDATENSASSL-------AP-------------- 593

Query: 627  QPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHL 686
                   G   G   S+G+ A  P    D  KSP             R+  G  F S   
Sbjct: 594  -------GFIRGAQASSGSPAL-PRKQRD--KSPSSLLEDAKETCFTRDRKGGFFSS--F 641

Query: 687  WKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQ 746
             KK +  T  + ++   E      K++  +        G  + +  ++TLPR+ Q +  Q
Sbjct: 642  MKKRNAPTPPKRSSSFREMENQPHKKYELT--------GLPEQDRMAMTLPRNCQRSKLQ 693

Query: 747  FDSSTFGGH---------------KSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNE 791
             + +                    KSE+ A P +     ++  + RG    P R     +
Sbjct: 694  LERTVSTSSQPEENVDRANDMLPKKSEESAAPSRE--RPKAKLLPRGATALPLR-TPSGD 750

Query: 792  EAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPV 851
             A  E      +  PG     +   P  ++       G+    E G+     +PA A PV
Sbjct: 751  LAITE------KDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGWPSPAKAAPV 804

Query: 852  TPTS---KAGSGAPGGTSKGPAE------ESRVRRHKHSSE---SPGRDKGKLSRLKP-- 897
             PT+   K            PA+      +S+  + K  SE   +   DK +  R+KP  
Sbjct: 805  LPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRPRRVKPKC 864

Query: 898  APPPPPAASA---GKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEG 954
            APPPPP             P++ P+   AG++                      S+  EG
Sbjct: 865  APPPPPVMRLLQHPSICSDPTEEPTALTAGQST---------------------SETQEG 903

Query: 955  LKKPVLPATPKPQSAKPSGTPISPAP-VPSTLPSASSALAGDQPSSTAFIPLISTRVSLR 1013
             KK  L A P    A   G P+ P P VP  LP++S + A    + TA      T+V+LR
Sbjct: 904  GKKAALGAVPISGKA---GRPVMPPPQVP--LPTSSISPA-KMANGTA-----GTKVALR 952

Query: 1014 KTRQPPERIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDS 1073
            KT+Q  E+I++  I+K  +L+  + L  A++    +   +S +++ G  L  +C  YVD 
Sbjct: 953  KTKQAAEKISADKISKEALLECADLLSSALT----EPVPNSQLVDTGHQLLDYCSGYVDC 1008

Query: 1074 IQQMRNKFAFREAINKLENNLRELQICPATAGSGPAATQDFSKLLSSVKEISDIVQR 1130
            I Q RNKFAFREA++KLE +L+ELQ+  A AG  P      + LLS V+EISD+VQR
Sbjct: 1009 IPQTRNKFAFREAVSKLELSLQELQVSSAAAGV-PGTNPVLNNLLSCVQEISDVVQR 1064


>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
          Length = 542

 Score =  884 bits (2283), Expect = 0.0
 Identities = 427/478 (89%), Positives = 452/478 (94%), Gaps = 1/478 (0%)

Query: 27  EALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGE 86
           EAL RP   D EPQ L+EA RW+SKENLL G +E+DPNLFVALYDFVASGDNTLSITKGE
Sbjct: 53  EALHRPYGCDVEPQALNEAIRWSSKENLL-GATESDPNLFVALYDFVASGDNTLSITKGE 111

Query: 87  KLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGIN 146
           KLRVLGYN NGEW E ++KNGQGWVPSNYITPVNSLEKHSWYHGPVSR+AAEYLLSS IN
Sbjct: 112 KLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN 171

Query: 147 GSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVA 206
           GSFLVRESESSPGQ SISLRYEGRVYHYRINT +DGK+YV++ESRF+TLAELVHHHSTVA
Sbjct: 172 GSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVA 231

Query: 207 DGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSL 266
           DGL+TTLHYPAPK NKPTVYGVSP +DKWEMERTDITMKHKLGGGQYGEVY GVWKKYSL
Sbjct: 232 DGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSL 291

Query: 267 TVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDY 326
           TVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT EPPFYI+TE+M YGNLLDY
Sbjct: 292 TVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDY 351

Query: 327 LRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSR 386
           LRECNR+EV AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENH+VKVADFGLSR
Sbjct: 352 LRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR 411

Query: 387 LMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLS 446
           LMTGDTYTAHAGAKFPIKWTAPESLAYN FSIKSDVWAFGVLLWEIATYGMSPYPGIDLS
Sbjct: 412 LMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLS 471

Query: 447 QVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISD 504
           QVY+LLEK YRME+PEGCP KVYELMRACW+W+P+DRPSFAE HQAFETMF +SSIS+
Sbjct: 472 QVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISE 529


>gi|4503787 fyn-related kinase [Homo sapiens]
          Length = 505

 Score =  380 bits (975), Expect = e-105
 Identities = 198/466 (42%), Positives = 286/466 (61%), Gaps = 16/466 (3%)

Query: 54  LLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWC--------EAQTK 105
           L +  S+   + FVAL+D+ A     LS   G+KL+VL   H G W         +  ++
Sbjct: 35  LCSPQSQRHGHYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQ 94

Query: 106 NGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAE--YLLSSGINGSFLVRESESSPGQRSI 163
             QG++PSNY+    SL+   W+ G + R+ AE   L S    GSFL+RESES  G+ S+
Sbjct: 95  QLQGYIPSNYVAEDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSL 154

Query: 164 SLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKP 223
           S+     V HYRI    +G  +++    F+TL E V H++  +DGL   L  P  K   P
Sbjct: 155 SVLDGAVVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVP 214

Query: 224 TVYGVS-PNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEE 282
             + +S    D+WE++R  I +  +LG GQ+GEV+EG+W   +  VAVKTLK  +M+  +
Sbjct: 215 APFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNN-TTPVAVKTLKPGSMDPND 273

Query: 283 FLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLY 342
           FL+EA +MK ++HP L+QL  VCT E P YIITE M +G+L +YL+     +++    + 
Sbjct: 274 FLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVD 333

Query: 343 MATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM---TGDTYTAHAGA 399
           MA Q++S M YLE +N+IHRDLAARN LVGE+++ KVADFGL+R+      D Y +    
Sbjct: 334 MAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEI 393

Query: 400 KFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRME 459
           K P+KWTAPE++  NKFSIKSDVW+FG+LL+EI TYG  PY G+  +QV ++L ++YR+ 
Sbjct: 394 KLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLP 453

Query: 460 RPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQ-ESSISD 504
           +P  CP++ Y +M  CW   P +RP+F  +    E  F+ +SS SD
Sbjct: 454 QPSNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYFETDSSYSD 499


>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
          Length = 543

 Score =  369 bits (947), Expect = e-102
 Identities = 198/442 (44%), Positives = 281/442 (63%), Gaps = 15/442 (3%)

Query: 65  LFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQT--KNGQGWVPSNYITPVNSL 122
           +FVALYD+ A     LS  KGE+ +++  N  G+W EA++      G++PSNY+ P +S+
Sbjct: 95  IFVALYDYEARTTEDLSFKKGERFQIIN-NTEGDWWEARSIATGKNGYIPSNYVAPADSI 153

Query: 123 EKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLR-----YEGRVYHYR 175
           +   WY G + R  AE LL +  N  G FLVRESE++ G  S+S+R         V HY+
Sbjct: 154 QAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYK 213

Query: 176 INTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKW 235
           I    +G  Y+++ ++F+TL +LV H++  ADGL   L    P   KP   G++   D W
Sbjct: 214 IRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTV-KPQTQGLAK--DAW 270

Query: 236 EMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 295
           E+ R  + ++ KLG G +GEV+ G W   +  VA+KTLK  TM  E FL+EA +MK+++H
Sbjct: 271 EIPRESLRLEVKLGQGCFGEVWMGTWNG-TTKVAIKTLKPGTMMPEAFLQEAQIMKKLRH 329

Query: 296 PNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLE 355
             LV L  V + EP  YI+TEFM+ G+LLD+L+E + + +    L+ MA QI+  M Y+E
Sbjct: 330 DKLVPLYAVVSEEP-IYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIE 388

Query: 356 KKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNK 415
           + N+IHRDL A N LVGEN + K+ADFGL+RL+  + YTA  GAKFPIKWTAPE+  Y +
Sbjct: 389 RMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 448

Query: 416 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRAC 475
           F+IKSDVW+FG+L  E+ T G  PYPG+   +V E +E+ YRM  P+GCPE ++ELM  C
Sbjct: 449 FTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLC 508

Query: 476 WQWNPSDRPSFAEIHQAFETMF 497
           W+ +P +RP+F  I    E  F
Sbjct: 509 WKKDPDERPTFEYIQSFLEDYF 530


>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
          Length = 537

 Score =  365 bits (937), Expect = e-100
 Identities = 195/443 (44%), Positives = 280/443 (63%), Gaps = 14/443 (3%)

Query: 65  LFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQ--TKNGQGWVPSNYITPVNSL 122
           LFVALYD+ A  ++ LS  KGEK ++L  +  G+W EA+  T    G++PSNY+ PV+S+
Sbjct: 86  LFVALYDYEARTEDDLSFHKGEKFQILN-SSEGDWWEARSLTTGETGYIPSNYVAPVDSI 144

Query: 123 EKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLR-----YEGRVYHYR 175
           +   WY G + R  AE  L S  N  G+FL+RESE++ G  S+S+R         V HY+
Sbjct: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK 204

Query: 176 INTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVS-PNYDK 234
           I    +G  Y+++ ++F TL +LV H+S  A GL   L  P  K   P +  +S    D 
Sbjct: 205 IRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHK-GMPRLTDLSVKTKDV 263

Query: 235 WEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK 294
           WE+ R  + +  +LG GQ+GEV+ G W   +  VA+KTLK  TM  E FL+EA +MK++K
Sbjct: 264 WEIPRESLQLIKRLGNGQFGEVWMGTWNG-NTKVAIKTLKPGTMSPESFLEEAQIMKKLK 322

Query: 295 HPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYL 354
           H  LVQL  V + EP  YI+TE+M  G+LLD+L++   + +    L+ MA Q+++ M Y+
Sbjct: 323 HDKLVQLYAVVSEEP-IYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYI 381

Query: 355 EKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYN 414
           E+ N+IHRDL + N LVG   + K+ADFGL+RL+  + YTA  GAKFPIKWTAPE+  Y 
Sbjct: 382 ERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 441

Query: 415 KFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRA 474
           +F+IKSDVW+FG+LL E+ T G  PYPG++  +V E +E+ YRM  P+ CP  ++ELM  
Sbjct: 442 RFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIH 501

Query: 475 CWQWNPSDRPSFAEIHQAFETMF 497
           CW+ +P +RP+F  +    E  F
Sbjct: 502 CWKKDPEERPTFEYLQSFLEDYF 524


>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score =  364 bits (935), Expect = e-100
 Identities = 197/452 (43%), Positives = 278/452 (61%), Gaps = 15/452 (3%)

Query: 55  LAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNG--QGWVP 112
           + G S     LF+ALYD+ A  ++ L+ TKGEK  +L  N  G+W EA++ +    G +P
Sbjct: 71  IRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILN-NTEGDWWEARSLSSGKTGCIP 129

Query: 113 SNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLR---- 166
           SNY+ PV+S++   WY G + R  AE  L S  N  G+FL+RESE++ G  S+S+R    
Sbjct: 130 SNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQ 189

Query: 167 -YEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTV 225
                V HY+I     G  Y+++  +FN++ ELV H+  V DGL   L  P     KP  
Sbjct: 190 TRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIM-KPQT 248

Query: 226 YGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLK 285
            G++   D WE+ R+ IT++ +LG G +G+V+ G W   S  VAVKTLK  TM  + FL+
Sbjct: 249 LGLAK--DAWEISRSSITLERRLGTGCFGDVWLGTWNG-STKVAVKTLKPGTMSPKAFLE 305

Query: 286 EAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMAT 345
           EA VMK ++H  LVQL  V + EP  YI+TEFM +G+LLD+L+    Q++    L+ MA 
Sbjct: 306 EAQVMKLLRHDKLVQLYAVVSEEP-IYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAA 364

Query: 346 QISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKW 405
           Q++  M Y+E+ N+IHRDL A N LVGE    K+ADFGL+RL+  D Y    G+KFPIKW
Sbjct: 365 QVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKW 424

Query: 406 TAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP 465
           TAPE+  + +F+IKSDVW+FG+LL E+ T G  PYPG++  +V E +E+ Y M  P GCP
Sbjct: 425 TAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCP 484

Query: 466 EKVYELMRACWQWNPSDRPSFAEIHQAFETMF 497
             +YE M   W+ +P +RP+F  +    E  F
Sbjct: 485 ASLYEAMEQTWRLDPEERPTFEYLQSFLEDYF 516


>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score =  364 bits (935), Expect = e-100
 Identities = 197/452 (43%), Positives = 278/452 (61%), Gaps = 15/452 (3%)

Query: 55  LAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNG--QGWVP 112
           + G S     LF+ALYD+ A  ++ L+ TKGEK  +L  N  G+W EA++ +    G +P
Sbjct: 71  IRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILN-NTEGDWWEARSLSSGKTGCIP 129

Query: 113 SNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLR---- 166
           SNY+ PV+S++   WY G + R  AE  L S  N  G+FL+RESE++ G  S+S+R    
Sbjct: 130 SNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQ 189

Query: 167 -YEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTV 225
                V HY+I     G  Y+++  +FN++ ELV H+  V DGL   L  P     KP  
Sbjct: 190 TRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIM-KPQT 248

Query: 226 YGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLK 285
            G++   D WE+ R+ IT++ +LG G +G+V+ G W   S  VAVKTLK  TM  + FL+
Sbjct: 249 LGLAK--DAWEISRSSITLERRLGTGCFGDVWLGTWNG-STKVAVKTLKPGTMSPKAFLE 305

Query: 286 EAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMAT 345
           EA VMK ++H  LVQL  V + EP  YI+TEFM +G+LLD+L+    Q++    L+ MA 
Sbjct: 306 EAQVMKLLRHDKLVQLYAVVSEEP-IYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAA 364

Query: 346 QISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKW 405
           Q++  M Y+E+ N+IHRDL A N LVGE    K+ADFGL+RL+  D Y    G+KFPIKW
Sbjct: 365 QVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKW 424

Query: 406 TAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP 465
           TAPE+  + +F+IKSDVW+FG+LL E+ T G  PYPG++  +V E +E+ Y M  P GCP
Sbjct: 425 TAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCP 484

Query: 466 EKVYELMRACWQWNPSDRPSFAEIHQAFETMF 497
             +YE M   W+ +P +RP+F  +    E  F
Sbjct: 485 ASLYEAMEQTWRLDPEERPTFEYLQSFLEDYF 516


>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score =  364 bits (935), Expect = e-100
 Identities = 197/452 (43%), Positives = 278/452 (61%), Gaps = 15/452 (3%)

Query: 55  LAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNG--QGWVP 112
           + G S     LF+ALYD+ A  ++ L+ TKGEK  +L  N  G+W EA++ +    G +P
Sbjct: 71  IRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILN-NTEGDWWEARSLSSGKTGCIP 129

Query: 113 SNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLR---- 166
           SNY+ PV+S++   WY G + R  AE  L S  N  G+FL+RESE++ G  S+S+R    
Sbjct: 130 SNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQ 189

Query: 167 -YEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTV 225
                V HY+I     G  Y+++  +FN++ ELV H+  V DGL   L  P     KP  
Sbjct: 190 TRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIM-KPQT 248

Query: 226 YGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLK 285
            G++   D WE+ R+ IT++ +LG G +G+V+ G W   S  VAVKTLK  TM  + FL+
Sbjct: 249 LGLAK--DAWEISRSSITLERRLGTGCFGDVWLGTWNG-STKVAVKTLKPGTMSPKAFLE 305

Query: 286 EAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMAT 345
           EA VMK ++H  LVQL  V + EP  YI+TEFM +G+LLD+L+    Q++    L+ MA 
Sbjct: 306 EAQVMKLLRHDKLVQLYAVVSEEP-IYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAA 364

Query: 346 QISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKW 405
           Q++  M Y+E+ N+IHRDL A N LVGE    K+ADFGL+RL+  D Y    G+KFPIKW
Sbjct: 365 QVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKW 424

Query: 406 TAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP 465
           TAPE+  + +F+IKSDVW+FG+LL E+ T G  PYPG++  +V E +E+ Y M  P GCP
Sbjct: 425 TAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCP 484

Query: 466 EKVYELMRACWQWNPSDRPSFAEIHQAFETMF 497
             +YE M   W+ +P +RP+F  +    E  F
Sbjct: 485 ASLYEAMEQTWRLDPEERPTFEYLQSFLEDYF 516


>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
           sapiens]
          Length = 536

 Score =  363 bits (933), Expect = e-100
 Identities = 196/450 (43%), Positives = 280/450 (62%), Gaps = 13/450 (2%)

Query: 56  AGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQ-GWVPSN 114
           AGP       FVALYD+ +  +  LS  KGE+L+++       W       GQ G++PSN
Sbjct: 79  AGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSN 138

Query: 115 YITPVNSLEKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISL----RYE 168
           Y+ P +S++   WY G ++R  +E LL +  N  G+FLVRESE++ G   +S+      +
Sbjct: 139 YVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAK 198

Query: 169 G-RVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYG 227
           G  V HY+I     G  Y++S ++FN+L +LV ++S  ADGL   L    P  +KP   G
Sbjct: 199 GLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT-SKPQTQG 257

Query: 228 VSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEA 287
           ++   D WE+ R  + ++ KLG G +GEV+ G W   +  VA+KTLK  TM  E FL+EA
Sbjct: 258 LAK--DAWEIPRESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGTMSPEAFLQEA 314

Query: 288 AVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQI 347
            VMK+++H  LVQL  V + EP  YI+TE+M+ G+LLD+L+    + +    L+ MA QI
Sbjct: 315 QVMKKLRHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQI 373

Query: 348 SSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTA 407
           +S M Y+E+ N++HRDL A N LVGEN + KVADFGL+RL+  + YTA  GAKFPIKWTA
Sbjct: 374 ASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTA 433

Query: 408 PESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEK 467
           PE+  Y +F+IKSDVW+FG+LL E+ T G  PYPG+   +V + +E+ YRM  P  CPE 
Sbjct: 434 PEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPES 493

Query: 468 VYELMRACWQWNPSDRPSFAEIHQAFETMF 497
           +++LM  CW+  P +RP+F  +    E  F
Sbjct: 494 LHDLMCQCWRKEPEERPTFEYLQAFLEDYF 523


>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
           sapiens]
          Length = 536

 Score =  363 bits (933), Expect = e-100
 Identities = 196/450 (43%), Positives = 280/450 (62%), Gaps = 13/450 (2%)

Query: 56  AGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQ-GWVPSN 114
           AGP       FVALYD+ +  +  LS  KGE+L+++       W       GQ G++PSN
Sbjct: 79  AGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSN 138

Query: 115 YITPVNSLEKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISL----RYE 168
           Y+ P +S++   WY G ++R  +E LL +  N  G+FLVRESE++ G   +S+      +
Sbjct: 139 YVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAK 198

Query: 169 G-RVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYG 227
           G  V HY+I     G  Y++S ++FN+L +LV ++S  ADGL   L    P  +KP   G
Sbjct: 199 GLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT-SKPQTQG 257

Query: 228 VSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEA 287
           ++   D WE+ R  + ++ KLG G +GEV+ G W   +  VA+KTLK  TM  E FL+EA
Sbjct: 258 LAK--DAWEIPRESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGTMSPEAFLQEA 314

Query: 288 AVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQI 347
            VMK+++H  LVQL  V + EP  YI+TE+M+ G+LLD+L+    + +    L+ MA QI
Sbjct: 315 QVMKKLRHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQI 373

Query: 348 SSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTA 407
           +S M Y+E+ N++HRDL A N LVGEN + KVADFGL+RL+  + YTA  GAKFPIKWTA
Sbjct: 374 ASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTA 433

Query: 408 PESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEK 467
           PE+  Y +F+IKSDVW+FG+LL E+ T G  PYPG+   +V + +E+ YRM  P  CPE 
Sbjct: 434 PEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPES 493

Query: 468 VYELMRACWQWNPSDRPSFAEIHQAFETMF 497
           +++LM  CW+  P +RP+F  +    E  F
Sbjct: 494 LHDLMCQCWRKEPEERPTFEYLQAFLEDYF 523


>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
          Length = 534

 Score =  362 bits (930), Expect = e-100
 Identities = 194/442 (43%), Positives = 279/442 (63%), Gaps = 15/442 (3%)

Query: 65  LFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQ--TKNGQGWVPSNYITPVNSL 122
           LFVALYD+ A  ++ LS  KGEK ++L  +  G+W EA+  T    G++PSNY+ PV+S+
Sbjct: 86  LFVALYDYEARTEDDLSFHKGEKFQILN-SSEGDWWEARSLTTGETGYIPSNYVAPVDSI 144

Query: 123 EKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLR-----YEGRVYHYR 175
           +   WY G + R  AE  L S  N  G+FL+RESE++ G  S+S+R         V HY+
Sbjct: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK 204

Query: 176 INTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKW 235
           I    +G  Y+++ ++F TL +LV H+S  ADGL   L   A     P   G++   D W
Sbjct: 205 IRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCT-PQTSGLAK--DAW 261

Query: 236 EMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 295
           E+ R  + ++ KLG G + EV+ G W   +  VA+KTLK  TM  E FL+EA +MK++KH
Sbjct: 262 EVARRSLCLEKKLGQGCFAEVWLGTWNG-NTKVAIKTLKPGTMSPESFLEEAQIMKKLKH 320

Query: 296 PNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLE 355
             LVQL  V + EP  YI+TE+M  G+LLD+L++   + +    L+ MA Q+++ M Y+E
Sbjct: 321 DKLVQLYAVVSEEP-IYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIE 379

Query: 356 KKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNK 415
           + N+IHRDL + N LVG   + K+ADFGL+RL+  + YTA  GAKFPIKWTAPE+  Y +
Sbjct: 380 RMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 439

Query: 416 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRAC 475
           F+IKSDVW+FG+LL E+ T G  PYPG++  +V E +E+ YRM  P+ CP  ++ELM  C
Sbjct: 440 FTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHC 499

Query: 476 WQWNPSDRPSFAEIHQAFETMF 497
           W+ +P +RP+F  +    E  F
Sbjct: 500 WKKDPEERPTFEYLQSFLEDYF 521


>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
           [Homo sapiens]
          Length = 509

 Score =  359 bits (921), Expect = 9e-99
 Identities = 195/443 (44%), Positives = 280/443 (63%), Gaps = 17/443 (3%)

Query: 64  NLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQ--TKNGQGWVPSNYITPVNS 121
           NL +AL+ +  S D  L   KGE+LR+L    +GEW +AQ  T   +G++P N++   NS
Sbjct: 64  NLVIALHSYEPSHDGDLGFEKGEQLRIL--EQSGEWWKAQSLTTGQEGFIPFNFVAKANS 121

Query: 122 LEKHSWYHGPVSRNAAE-YLLSSG-INGSFLVRESESSPGQRSISLR----YEGRVY-HY 174
           LE   W+   +SR  AE  LL+ G  +GSFL+RESES+ G  S+S+R     +G V  HY
Sbjct: 122 LEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHY 181

Query: 175 RINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDK 234
           +I    +G  Y+S    F  L ELV H++  +DGL T L  P   +     +      D+
Sbjct: 182 KIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWE----DE 237

Query: 235 WEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK 294
           WE+ R  + +  +LG GQ+GEV+ G +  ++  VAVK+LK+ +M  + FL EA +MK+++
Sbjct: 238 WEVPRETLKLVERLGAGQFGEVWMGYYNGHT-KVAVKSLKQGSMSPDAFLAEANLMKQLQ 296

Query: 295 HPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYL 354
           H  LV+L  V T+EP  YIITE+M  G+L+D+L+  +  ++    LL MA QI+  M ++
Sbjct: 297 HQRLVRLYAVVTQEP-IYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFI 355

Query: 355 EKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYN 414
           E++N+IHRDL A N LV +    K+ADFGL+RL+  + YTA  GAKFPIKWTAPE++ Y 
Sbjct: 356 EERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYG 415

Query: 415 KFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRA 474
            F+IKSDVW+FG+LL EI T+G  PYPG+   +V + LE+ YRM RP+ CPE++Y+LMR 
Sbjct: 416 TFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRL 475

Query: 475 CWQWNPSDRPSFAEIHQAFETMF 497
           CW+  P DRP+F  +    E  F
Sbjct: 476 CWKERPEDRPTFDYLRSVLEDFF 498


>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
           [Homo sapiens]
          Length = 509

 Score =  359 bits (921), Expect = 9e-99
 Identities = 195/443 (44%), Positives = 280/443 (63%), Gaps = 17/443 (3%)

Query: 64  NLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQ--TKNGQGWVPSNYITPVNS 121
           NL +AL+ +  S D  L   KGE+LR+L    +GEW +AQ  T   +G++P N++   NS
Sbjct: 64  NLVIALHSYEPSHDGDLGFEKGEQLRIL--EQSGEWWKAQSLTTGQEGFIPFNFVAKANS 121

Query: 122 LEKHSWYHGPVSRNAAE-YLLSSG-INGSFLVRESESSPGQRSISLR----YEGRVY-HY 174
           LE   W+   +SR  AE  LL+ G  +GSFL+RESES+ G  S+S+R     +G V  HY
Sbjct: 122 LEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHY 181

Query: 175 RINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDK 234
           +I    +G  Y+S    F  L ELV H++  +DGL T L  P   +     +      D+
Sbjct: 182 KIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWE----DE 237

Query: 235 WEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK 294
           WE+ R  + +  +LG GQ+GEV+ G +  ++  VAVK+LK+ +M  + FL EA +MK+++
Sbjct: 238 WEVPRETLKLVERLGAGQFGEVWMGYYNGHT-KVAVKSLKQGSMSPDAFLAEANLMKQLQ 296

Query: 295 HPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYL 354
           H  LV+L  V T+EP  YIITE+M  G+L+D+L+  +  ++    LL MA QI+  M ++
Sbjct: 297 HQRLVRLYAVVTQEP-IYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFI 355

Query: 355 EKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYN 414
           E++N+IHRDL A N LV +    K+ADFGL+RL+  + YTA  GAKFPIKWTAPE++ Y 
Sbjct: 356 EERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYG 415

Query: 415 KFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRA 474
            F+IKSDVW+FG+LL EI T+G  PYPG+   +V + LE+ YRM RP+ CPE++Y+LMR 
Sbjct: 416 TFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRL 475

Query: 475 CWQWNPSDRPSFAEIHQAFETMF 497
           CW+  P DRP+F  +    E  F
Sbjct: 476 CWKERPEDRPTFDYLRSVLEDFF 498


>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
          Length = 526

 Score =  358 bits (918), Expect = 2e-98
 Identities = 196/444 (44%), Positives = 279/444 (62%), Gaps = 21/444 (4%)

Query: 65  LFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQT--KNGQGWVPSNYITPVNSL 122
           + VALYD+ A     LS  KG+++ VL    +GEW +A++     +G++PSNY+  V+SL
Sbjct: 82  IVVALYDYEAIHHEDLSFQKGDQMVVL--EESGEWWKARSLATRKEGYIPSNYVARVDSL 139

Query: 123 EKHSWYHGPVSRNAAE-YLLSSG-INGSFLVRESESSPGQRSISLR-YEGR----VYHYR 175
           E   W+   +SR  AE  LL+ G + GSF++R+SE++ G  S+S+R Y+ R    V HY+
Sbjct: 140 ETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYK 199

Query: 176 INTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYP--APKRNKPTVYGVSPNYD 233
           I T  +G  Y+S  S F+TL ELV H+    DGL   L  P  + K  KP         D
Sbjct: 200 IRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPW------EKD 253

Query: 234 KWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEI 293
            WE+ R  + ++ KLG GQ+GEV+   + K++  VAVKT+K  +M VE FL EA VMK +
Sbjct: 254 AWEIPRESLKLEKKLGAGQFGEVWMATYNKHT-KVAVKTMKPGSMSVEAFLAEANVMKTL 312

Query: 294 KHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEY 353
           +H  LV+L  V T+EP  YIITEFM  G+LLD+L+     +     L+  + QI+  M +
Sbjct: 313 QHDKLVKLHAVVTKEP-IYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAF 371

Query: 354 LEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAY 413
           +E++N+IHRDL A N LV  + + K+ADFGL+R++  + YTA  GAKFPIKWTAPE++ +
Sbjct: 372 IEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINF 431

Query: 414 NKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMR 473
             F+IKSDVW+FG+LL EI TYG  PYPG+   +V   LE+ YRM RPE CPE++Y +M 
Sbjct: 432 GSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMM 491

Query: 474 ACWQWNPSDRPSFAEIHQAFETMF 497
            CW+  P +RP+F  I    +  +
Sbjct: 492 RCWKNRPEERPTFEYIQSVLDDFY 515


>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
           isoform B [Homo sapiens]
          Length = 491

 Score =  350 bits (899), Expect = 3e-96
 Identities = 199/500 (39%), Positives = 295/500 (59%), Gaps = 31/500 (6%)

Query: 9   VGCKSKKGLSSSSSCYLEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVA 68
           +GC   KG  S S   ++   Q    S   P       R+ +K+       E   ++ VA
Sbjct: 1   MGCIKSKGKDSLSDDGVDLKTQPVPESQLLP-----GQRFQTKD------PEEQGDIVVA 49

Query: 69  LYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQT--KNGQGWVPSNYITPVNSLEKHS 126
           LY +     + LS  KGEK++VL    +GEW +A++     +G++PSNY+  +N+LE   
Sbjct: 50  LYPYDGIHPDDLSFKKGEKMKVL--EEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEE 107

Query: 127 WYHGPVSRNAAE-YLLSSGIN-GSFLVRESESSPGQRSISLRYEGRVY-----HYRINTA 179
           W+   ++R  AE  LL+ G + G+FL+RESE+  G  S+S+R    V+     HY+I + 
Sbjct: 108 WFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSL 167

Query: 180 SDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYP--APKRNKPTVYGVSPNYDKWEM 237
            +G  Y+S    F  +++++ H+   ADGL   L     +PK  KP       + D WE+
Sbjct: 168 DNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPW------DKDAWEI 221

Query: 238 ERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPN 297
            R  I +  +LG GQ+GEV+ G +   S  VAVKTLK  TM V+ FL+EA +MK ++H  
Sbjct: 222 PRESIKLVKRLGAGQFGEVWMGYYNN-STKVAVKTLKPGTMSVQAFLEEANLMKTLQHDK 280

Query: 298 LVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK 357
           LV+L  V TRE P YIITE+M  G+LLD+L+     +V    L+  + QI+  M Y+E+K
Sbjct: 281 LVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERK 340

Query: 358 NFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFS 417
           N+IHRDL A N LV E+ + K+ADFGL+R++  + YTA  GAKFPIKWTAPE++ +  F+
Sbjct: 341 NYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFT 400

Query: 418 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQ 477
           IKSDVW+FG+LL+EI TYG  PYPG   + V   L + YRM R E CP+++Y++M+ CW+
Sbjct: 401 IKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWK 460

Query: 478 WNPSDRPSFAEIHQAFETMF 497
               +RP+F  +    +  +
Sbjct: 461 EKAEERPTFDYLQSVLDDFY 480


>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
           isoform A [Homo sapiens]
          Length = 512

 Score =  348 bits (894), Expect = 1e-95
 Identities = 188/449 (41%), Positives = 278/449 (61%), Gaps = 20/449 (4%)

Query: 60  ENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQT--KNGQGWVPSNYIT 117
           E   ++ VALY +     + LS  KGEK++VL    +GEW +A++     +G++PSNY+ 
Sbjct: 62  EEQGDIVVALYPYDGIHPDDLSFKKGEKMKVL--EEHGEWWKAKSLLTKKEGFIPSNYVA 119

Query: 118 PVNSLEKHSWYHGPVSRNAAE-YLLSSGIN-GSFLVRESESSPGQRSISLRYEGRVY--- 172
            +N+LE   W+   ++R  AE  LL+ G + G+FL+RESE+  G  S+S+R    V+   
Sbjct: 120 KLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDV 179

Query: 173 --HYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYP--APKRNKPTVYGV 228
             HY+I +  +G  Y+S    F  +++++ H+   ADGL   L     +PK  KP     
Sbjct: 180 IKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPW---- 235

Query: 229 SPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAA 288
             + D WE+ R  I +  +LG GQ+GEV+ G +   S  VAVKTLK  TM V+ FL+EA 
Sbjct: 236 --DKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNN-STKVAVKTLKPGTMSVQAFLEEAN 292

Query: 289 VMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQIS 348
           +MK ++H  LV+L  V TRE P YIITE+M  G+LLD+L+     +V    L+  + QI+
Sbjct: 293 LMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIA 352

Query: 349 SAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAP 408
             M Y+E+KN+IHRDL A N LV E+ + K+ADFGL+R++  + YTA  GAKFPIKWTAP
Sbjct: 353 EGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAP 412

Query: 409 ESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKV 468
           E++ +  F+IKSDVW+FG+LL+EI TYG  PYPG   + V   L + YRM R E CP+++
Sbjct: 413 EAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDEL 472

Query: 469 YELMRACWQWNPSDRPSFAEIHQAFETMF 497
           Y++M+ CW+    +RP+F  +    +  +
Sbjct: 473 YDIMKMCWKEKAEERPTFDYLQSVLDDFY 501


>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
          Length = 659

 Score =  340 bits (873), Expect = 3e-93
 Identities = 185/444 (41%), Positives = 268/444 (60%), Gaps = 13/444 (2%)

Query: 52  ENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQ-GW 110
           E   A  S ++    VALYD++    N L + KG++  +L  + N  W  A+ KNGQ G+
Sbjct: 205 EPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEES-NLPWWRARDKNGQEGY 263

Query: 111 VPSNYITPV-NSLEKHSWYHGPVSRNAAEYLLSS-GINGSFLVRESESSPGQRSISLRY- 167
           +PSNY+T   +S+E + WY   ++R+ AE LL   G  G F+VR+S S  G+ ++S+   
Sbjct: 264 IPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDS-SKAGKYTVSVFAK 322

Query: 168 -----EGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNK 222
                +G + HY + +    + Y++ +  F+T+ EL+++H   + GLI+ L YP  ++NK
Sbjct: 323 STGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNK 382

Query: 223 PTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEE 282
                    Y  WE++  D+T   +LG GQ+G V  G W+     VA+K +KE +M  +E
Sbjct: 383 NAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIKEGSMSEDE 441

Query: 283 FLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLY 342
           F++EA VM  + H  LVQL GVCT++ P +IITE+M  G LL+YLRE  R       LL 
Sbjct: 442 FIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREM-RHRFQTQQLLE 500

Query: 343 MATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFP 402
           M   +  AMEYLE K F+HRDLAARNCLV +  +VKV+DFGLSR +  D YT+  G+KFP
Sbjct: 501 MCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFP 560

Query: 403 IKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPE 462
           ++W+ PE L Y+KFS KSD+WAFGVL+WEI + G  PY     S+  E + +  R+ RP 
Sbjct: 561 VRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPH 620

Query: 463 GCPEKVYELMRACWQWNPSDRPSF 486
              EKVY +M +CW     +RP+F
Sbjct: 621 LASEKVYTIMYSCWHEKADERPTF 644


>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
          Length = 505

 Score =  340 bits (872), Expect = 4e-93
 Identities = 191/457 (41%), Positives = 273/457 (59%), Gaps = 18/457 (3%)

Query: 60  ENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQT--KNGQGWVPSNYIT 117
           + D +  VALYD+ A  D  L + KGEKL+VL     G+W  A++     +G+VPSN++ 
Sbjct: 57  DEDKHFVVALYDYTAMNDRDLQMLKGEKLQVL--KGTGDWWLARSLVTGREGYVPSNFVA 114

Query: 118 PVNSLEKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLR---YEGR-V 171
            V SLE   W+     R  AE  L + IN  GSFL+RESE++ G  S+S++    +G  +
Sbjct: 115 RVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELI 174

Query: 172 YHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPN 231
            HY+I    +G  Y+S    F +L  LV H+S   DGL   L  P  +      +     
Sbjct: 175 KHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWA---- 230

Query: 232 YDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMK 291
            D+WE+ R  + +  KLG GQ+GEV+ G +K  ++ VA+KTLKE TM  E FL EA VMK
Sbjct: 231 QDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKN-NMKVAIKTLKEGTMSPEAFLGEANVMK 289

Query: 292 EIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAM 351
            ++H  LV+L  V T+EP  YI+TE+M  G LLD+L+      ++   L+ M+ QI+  M
Sbjct: 290 ALQHERLVRLYAVVTKEP-IYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGM 348

Query: 352 EYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL 411
            Y+E+ N IHRDL A N LV E    K+ADFGL+R++  + YTA  GAKFPIKWTAPE++
Sbjct: 349 AYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSE-YTAQEGAKFPIKWTAPEAI 407

Query: 412 AYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYE- 470
            +  F+IK+DVW+FGVLL E+ TYG  PYPG+   +V   LE+ YRM RP+ CP ++Y  
Sbjct: 408 HFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRG 467

Query: 471 LMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVE 507
           ++  CW+  P +RP+F  +    E  +  +    E++
Sbjct: 468 VIAECWRSRPEERPTFEFLQSVLEDFYTATERQYELQ 504


>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
          Length = 631

 Score =  337 bits (865), Expect = 3e-92
 Identities = 183/453 (40%), Positives = 279/453 (61%), Gaps = 20/453 (4%)

Query: 60  ENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNG-QGWVPSNYIT- 117
           +N   + VA+YDF A+  + L + +G++  +L  N +  W  A+ K G +G++PSNY+T 
Sbjct: 178 DNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKN-DVHWWRARDKYGNEGYIPSNYVTG 236

Query: 118 -PVNSLEKHSWYHGPVSRNAAEYLL-SSGINGSFLVRESESSPGQRSISL--RYEG---- 169
              N+L+++ WY   ++R+ AE LL S    G F+VR+S S PG  ++SL  ++ G    
Sbjct: 237 KKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSS 295

Query: 170 --RVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNK--PTV 225
             R YH +  T S  K Y++ +  F ++ E++ +H   A GL+T L YP   + K  PT 
Sbjct: 296 GFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTT 355

Query: 226 YGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLK 285
            G S  Y+KWE+  +++T   +LG G +G V  G W+     VA+K ++E  M  E+F++
Sbjct: 356 AGFS--YEKWEINPSELTFMRELGSGLFGVVRLGKWRA-QYKVAIKAIREGAMCEEDFIE 412

Query: 286 EAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMAT 345
           EA VM ++ HP LVQL GVCT++ P YI+TEFM  G LL++LR+  +   +  VLL M  
Sbjct: 413 EAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQ-RQGHFSRDVLLSMCQ 471

Query: 346 QISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKW 405
            +   MEYLE+ +FIHRDLAARNCLV E  +VKV+DFG++R +  D YT+ +GAKFP+KW
Sbjct: 472 DVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKW 531

Query: 406 TAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP 465
             PE   Y++FS KSDVW+FGVL+WE+ T G  P+      +V  ++ + +R+ +P+   
Sbjct: 532 CPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLAS 591

Query: 466 EKVYELMRACWQWNPSDRPSFAEIHQAFETMFQ 498
             VYE+M  CWQ  P  RPSF ++ +  + + +
Sbjct: 592 NYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVE 624


>gi|148596974 TXK tyrosine kinase [Homo sapiens]
          Length = 527

 Score =  333 bits (854), Expect = 5e-91
 Identities = 177/437 (40%), Positives = 265/437 (60%), Gaps = 18/437 (4%)

Query: 68  ALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNG-QGWVPSNYITP--VNSLEK 124
           ALYDF+      L++ + E+  +L   +N  W +A+ + G +G +PSNY+T   + +LE 
Sbjct: 89  ALYDFLPREPCNLALRRAEEYLILE-KYNPHWWKARDRLGNEGLIPSNYVTENKITNLEI 147

Query: 125 HSWYHGPVSRNAAEYLL-SSGINGSFLVRESESSPGQRSISL------RYEGRVYHYRIN 177
           + WYH  ++RN AE+LL      G+F+VR+S    G  +IS+        E  + HY+I 
Sbjct: 148 YEWYHRNITRNQAEHLLRQESKEGAFIVRDSRHL-GSYTISVFMGARRSTEAAIKHYQIK 206

Query: 178 TASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNK--PTVYGVSPNYDKW 235
               G+ YV+    F ++ EL+ +H   A GL+T L YP        P   G S  Y+KW
Sbjct: 207 KNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFS--YEKW 264

Query: 236 EMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 295
           E++ +++    ++G GQ+G V+ G W+ + + VA+K + E +M  E+F++EA VM ++ H
Sbjct: 265 EIDPSELAFIKEIGSGQFGVVHLGEWRSH-IQVAIKAINEGSMSEEDFIEEAKVMMKLSH 323

Query: 296 PNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLE 355
             LVQL GVC +  P YI+TEFM  G LL+YLRE N+ ++   +LL +   I   MEYLE
Sbjct: 324 SKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRE-NKGKLRKEMLLSVCQDICEGMEYLE 382

Query: 356 KKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNK 415
           +  +IHRDLAARNCLV    +VK++DFG++R +  D Y +  GAKFPIKW+ PE   +NK
Sbjct: 383 RNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNK 442

Query: 416 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRAC 475
           +S KSDVW+FGVL+WE+ T G  P+      QV E + + +R+ RP   P  +YE+M +C
Sbjct: 443 YSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSC 502

Query: 476 WQWNPSDRPSFAEIHQA 492
           W   P  RP+FAE+ +A
Sbjct: 503 WHEKPEGRPTFAELLRA 519


>gi|18250298 src-related kinase lacking C-terminal regulatory
           tyrosine and N-terminal myristylation sites [Homo
           sapiens]
          Length = 488

 Score =  312 bits (800), Expect = 1e-84
 Identities = 176/445 (39%), Positives = 253/445 (56%), Gaps = 17/445 (3%)

Query: 54  LLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQ---GW 110
           L A P    P LF+ALYDF A     LS+ +G++L  L     G +  A+  +GQ   G 
Sbjct: 44  LPAEPCSPFPQLFLALYDFTARCGGELSVRRGDRLCAL--EEGGGYIFARRLSGQPSAGL 101

Query: 111 VPSNYITPVN--SLEKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLR 166
           VP  ++   +  +L    WY   VSR  A+ LL S  N  G+FL+R SESS G  S+S+R
Sbjct: 102 VPITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVR 161

Query: 167 YEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVY 226
            + +V HYR++ A+DG LY+     F  L EL+ ++      +   L  P   +      
Sbjct: 162 AQAKVCHYRVSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQPCMPQK----- 216

Query: 227 GVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKE 286
             +P  D WE   ++  +  KLG G +GEV+EG+W   SL VA+K +K   M++ +  KE
Sbjct: 217 --APRQDVWERPHSEFALGRKLGEGYFGEVWEGLWLG-SLPVAIKVIKSANMKLTDLAKE 273

Query: 287 AAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQ 346
              +K ++H  L++L  VC+   P YI+TE M  GNL  +L     + +    LL  A Q
Sbjct: 274 IQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQ 333

Query: 347 ISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWT 406
           ++  M YLE++  +HRDLAARN LV +    KVADFGL+RL+  D Y+  + +K P+KWT
Sbjct: 334 VAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWT 393

Query: 407 APESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPE 466
           APE+  Y  FS KSDVW+FGVLL E+ TYG  PY G+   +  + + + YR+ RP  CP 
Sbjct: 394 APEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPA 453

Query: 467 KVYELMRACWQWNPSDRPSFAEIHQ 491
           +VY LM  CW+ +P +RPSFA + +
Sbjct: 454 EVYVLMLECWRSSPEERPSFATLRE 478


>gi|187475373 c-src tyrosine kinase [Homo sapiens]
          Length = 450

 Score =  312 bits (799), Expect = 1e-84
 Identities = 175/437 (40%), Positives = 256/437 (58%), Gaps = 19/437 (4%)

Query: 67  VALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNG-QGWVPSNYITPVNSLEKH 125
           +A Y+F  + +  L   KG+ L ++    +  W +A+ K G +G +P+NY+     ++  
Sbjct: 15  IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAG 74

Query: 126 S------WYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTA 179
           +      W+HG ++R  AE LL     G FLVRES + PG  ++ +  +G+V HYRI   
Sbjct: 75  TKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYH 134

Query: 180 SDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDK-WEME 238
           +  KL +  E  F  L +LV H+++ ADGL T L    PK  + TV      Y   W + 
Sbjct: 135 AS-KLSIDEEVYFENLMQLVEHYTSDADGLCTRLI--KPKVMEGTVAAQDEFYRSGWALN 191

Query: 239 RTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNL 298
             ++ +   +G G++G+V  G ++     VAVK +K D    + FL EA+VM +++H NL
Sbjct: 192 MKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDAT-AQAFLAEASVMTQLRHSNL 248

Query: 299 VQLLGVCTREPP-FYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK 357
           VQLLGV   E    YI+TE+M  G+L+DYLR   R  +    LL  +  +  AMEYLE  
Sbjct: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308

Query: 358 NFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFS 417
           NF+HRDLAARN LV E+++ KV+DFGL++  +    T     K P+KWTAPE+L   KFS
Sbjct: 309 NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEALREKKFS 364

Query: 418 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQ 477
            KSDVW+FG+LLWEI ++G  PYP I L  V   +EK Y+M+ P+GCP  VYE+M+ CW 
Sbjct: 365 TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWH 424

Query: 478 WNPSDRPSFAEIHQAFE 494
            + + RPSF ++ +  E
Sbjct: 425 LDAAMRPSFLQLREQLE 441


>gi|4758078 c-src tyrosine kinase [Homo sapiens]
          Length = 450

 Score =  312 bits (799), Expect = 1e-84
 Identities = 175/437 (40%), Positives = 256/437 (58%), Gaps = 19/437 (4%)

Query: 67  VALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNG-QGWVPSNYITPVNSLEKH 125
           +A Y+F  + +  L   KG+ L ++    +  W +A+ K G +G +P+NY+     ++  
Sbjct: 15  IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAG 74

Query: 126 S------WYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTA 179
           +      W+HG ++R  AE LL     G FLVRES + PG  ++ +  +G+V HYRI   
Sbjct: 75  TKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYH 134

Query: 180 SDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDK-WEME 238
           +  KL +  E  F  L +LV H+++ ADGL T L    PK  + TV      Y   W + 
Sbjct: 135 AS-KLSIDEEVYFENLMQLVEHYTSDADGLCTRLI--KPKVMEGTVAAQDEFYRSGWALN 191

Query: 239 RTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNL 298
             ++ +   +G G++G+V  G ++     VAVK +K D    + FL EA+VM +++H NL
Sbjct: 192 MKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDAT-AQAFLAEASVMTQLRHSNL 248

Query: 299 VQLLGVCTREPP-FYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK 357
           VQLLGV   E    YI+TE+M  G+L+DYLR   R  +    LL  +  +  AMEYLE  
Sbjct: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308

Query: 358 NFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFS 417
           NF+HRDLAARN LV E+++ KV+DFGL++  +    T     K P+KWTAPE+L   KFS
Sbjct: 309 NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEALREKKFS 364

Query: 418 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQ 477
            KSDVW+FG+LLWEI ++G  PYP I L  V   +EK Y+M+ P+GCP  VYE+M+ CW 
Sbjct: 365 TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWH 424

Query: 478 WNPSDRPSFAEIHQAFE 494
            + + RPSF ++ +  E
Sbjct: 425 LDAAMRPSFLQLREQLE 441


>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
          Length = 620

 Score =  309 bits (792), Expect = 8e-84
 Identities = 167/445 (37%), Positives = 264/445 (59%), Gaps = 21/445 (4%)

Query: 60  ENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNG-QGWVPSNYITP 118
           E +  + +ALYD+  +    L++ + E+  +L  +    W   Q +NG +G+VPS+Y+  
Sbjct: 170 EPEETVVIALYDYQTNDPQELALRRNEEYCLLDSSEI-HWWRVQDRNGHEGYVPSSYLVE 228

Query: 119 V--NSLEKHSWYHGPVSRNAAE-YLLSSGINGSFLVRESESSPGQRSISLRYEGRVY--- 172
              N+LE + WY+  +SR+ AE  LL +G  G+F+VR+S ++ G  ++S+  +  V    
Sbjct: 229 KSPNNLETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRTA-GTYTVSVFTKAVVSENN 287

Query: 173 ----HYRINTASDG--KLYVSSESRFNTLAELVHHHSTVADGLITTLHYPA--PKRNKPT 224
               HY I   +D   + YV+ +  F+++  L+++H     GL+T L YP    ++  P 
Sbjct: 288 PCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPV 347

Query: 225 VYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFL 284
             G+   Y KW ++ +++T   ++G GQ+G V+ G W      VA+KT++E  M  E+F+
Sbjct: 348 TAGL--RYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKD-KVAIKTIREGAMSEEDFI 404

Query: 285 KEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMA 344
           +EA VM ++ HP LVQL GVC  + P  ++ EFM +G L DYLR   R    A  LL M 
Sbjct: 405 EEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRT-QRGLFAAETLLGMC 463

Query: 345 TQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIK 404
             +   M YLE+   IHRDLAARNCLVGEN ++KV+DFG++R +  D YT+  G KFP+K
Sbjct: 464 LDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVK 523

Query: 405 WTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGC 464
           W +PE  +++++S KSDVW+FGVL+WE+ + G  PY     S+V E +   +R+ +P   
Sbjct: 524 WASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLA 583

Query: 465 PEKVYELMRACWQWNPSDRPSFAEI 489
              VY++M  CW+  P DRP+F+ +
Sbjct: 584 STHVYQIMNHCWKERPEDRPAFSRL 608


>gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]
          Length = 482

 Score =  303 bits (775), Expect = 8e-82
 Identities = 175/442 (39%), Positives = 249/442 (56%), Gaps = 67/442 (15%)

Query: 65  LFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQ--TKNGQGWVPSNYITPVNSL 122
           LFVALYD+ A  ++ LS  KGEK ++L  +  G+W EA+  T    G++PSNY+ PV+S+
Sbjct: 86  LFVALYDYEARTEDDLSFHKGEKFQILN-SSEGDWWEARSLTTGETGYIPSNYVAPVDSI 144

Query: 123 EKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLR-----YEGRVYHYR 175
           +   WY G + R  AE  L S  N  G+FL+RESE++ G  S+S+R         V HY+
Sbjct: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK 204

Query: 176 INTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKW 235
           I    +G  Y                        ITT                     + 
Sbjct: 205 IRKLDNGGYY------------------------ITT---------------------RA 219

Query: 236 EMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 295
           + E     ++H          Y G W   +  VA+KTLK  TM  E FL+EA +MK++KH
Sbjct: 220 QFETLQQLVQH----------YSGTWNG-NTKVAIKTLKPGTMSPESFLEEAQIMKKLKH 268

Query: 296 PNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLE 355
             LVQL  V + EP  YI+TE+M  G+LLD+L++   + +    L+ MA Q+++ M Y+E
Sbjct: 269 DKLVQLYAVVSEEP-IYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIE 327

Query: 356 KKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNK 415
           + N+IHRDL + N LVG   + K+ADFGL+RL+  + YTA  GAKFPIKWTAPE+  Y +
Sbjct: 328 RMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 387

Query: 416 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRAC 475
           F+IKSDVW+FG+LL E+ T G  PYPG++  +V E +E+ YRM  P+ CP  ++ELM  C
Sbjct: 388 FTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHC 447

Query: 476 WQWNPSDRPSFAEIHQAFETMF 497
           W+ +P +RP+F  +    E  F
Sbjct: 448 WKKDPEERPTFEYLQSFLEDYF 469


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.129    0.375 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 50,638,092
Number of Sequences: 37866
Number of extensions: 2847857
Number of successful extensions: 23319
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 846
Number of HSP's successfully gapped in prelim test: 1611
Number of HSP's that attempted gapping in prelim test: 13822
Number of HSP's gapped (non-prelim): 7385
length of query: 1130
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1017
effective length of database: 13,968,660
effective search space: 14206127220
effective search space used: 14206127220
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.