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Search of human proteins with 62241040
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|62241040 leucine rich repeat containing 8 family, member A
[Homo sapiens]
(810 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|62241040 leucine rich repeat containing 8 family, member A [H... 1635 0.0
gi|187829877 leucine rich repeat containing 8 family, member A [... 1635 0.0
gi|187829871 leucine rich repeat containing 8 family, member A [... 1635 0.0
gi|19923729 leucine rich repeat containing 8 family, member C [H... 956 0.0
gi|197333692 leucine rich repeat containing 8 family, member B [... 956 0.0
gi|21245134 leucine rich repeat containing 8 family, member B [H... 956 0.0
gi|197333706 leucine rich repeat containing 8 family, member D [... 926 0.0
gi|34222199 leucine rich repeat containing 8 family, member D [H... 926 0.0
gi|40217803 leucine rich repeat containing 8 family, member E [H... 858 0.0
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 130 6e-30
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom... 124 3e-28
gi|45827729 scribble isoform b [Homo sapiens] 121 2e-27
gi|45827731 scribble isoform a [Homo sapiens] 121 2e-27
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 119 1e-26
gi|16904383 leucine rich repeat containing 7 [Homo sapiens] 118 3e-26
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 115 2e-25
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 115 2e-25
gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens] 109 1e-23
gi|238908508 leucine-rich repeat and death domain-containing pro... 103 6e-22
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 102 1e-21
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 101 2e-21
gi|4503743 flightless I homolog [Homo sapiens] 101 3e-21
gi|33285015 leucine rich repeat containing 28 [Homo sapiens] 100 4e-21
gi|61742786 leucine rich repeat and death domain containing prot... 100 7e-21
gi|61742784 leucine rich repeat and death domain containing prot... 100 7e-21
gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens] 94 5e-19
gi|21389431 leucine rich repeat containing 39 [Homo sapiens] 93 9e-19
gi|4758460 glycoprotein V (platelet) [Homo sapiens] 92 2e-18
gi|157743290 leucine rich repeat containing 30 [Homo sapiens] 92 3e-18
gi|193788651 leucine rich repeat containing 69 [Homo sapiens] 90 1e-17
>gi|62241040 leucine rich repeat containing 8 family, member A [Homo
sapiens]
Length = 810
Score = 1635 bits (4234), Expect = 0.0
Identities = 810/810 (100%), Positives = 810/810 (100%)
Query: 1 MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCKWV 60
MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCKWV
Sbjct: 1 MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCKWV 60
Query: 61 TKDSCNDSFRGWAAPGPEPTYPNSTILPTPDTGPTGIKYDLDRHQYNYVDAVCYENRLHW 120
TKDSCNDSFRGWAAPGPEPTYPNSTILPTPDTGPTGIKYDLDRHQYNYVDAVCYENRLHW
Sbjct: 61 TKDSCNDSFRGWAAPGPEPTYPNSTILPTPDTGPTGIKYDLDRHQYNYVDAVCYENRLHW 120
Query: 121 FAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVEE 180
FAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVEE
Sbjct: 121 FAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVEE 180
Query: 181 SDPKPAFSKMNGSMDKKSSTVSEDVEATVPMLQRTKSRIEQGIVDRSETGVLDKKEGEQA 240
SDPKPAFSKMNGSMDKKSSTVSEDVEATVPMLQRTKSRIEQGIVDRSETGVLDKKEGEQA
Sbjct: 181 SDPKPAFSKMNGSMDKKSSTVSEDVEATVPMLQRTKSRIEQGIVDRSETGVLDKKEGEQA 240
Query: 241 KALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFILIICYTVYYVHNIKFDVDCTVDIE 300
KALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFILIICYTVYYVHNIKFDVDCTVDIE
Sbjct: 241 KALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFILIICYTVYYVHNIKFDVDCTVDIE 300
Query: 301 SLTGYRTYRCAHPLATLFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESIREES 360
SLTGYRTYRCAHPLATLFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESIREES
Sbjct: 301 SLTGYRTYRCAHPLATLFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESIREES 360
Query: 361 SYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQRL 420
SYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQRL
Sbjct: 361 SYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQRL 420
Query: 421 TKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTA 480
TKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTA
Sbjct: 421 TKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTA 480
Query: 481 AKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGL 540
AKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGL
Sbjct: 481 AKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGL 540
Query: 541 RELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIR 600
RELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIR
Sbjct: 541 RELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIR 600
Query: 601 CDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGN 660
CDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGN
Sbjct: 601 CDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGN 660
Query: 661 LTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRI 720
LTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRI
Sbjct: 661 LTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRI 720
Query: 721 ETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK 780
ETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK
Sbjct: 721 ETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK 780
Query: 781 RSGLVVEEDLFNTLPPEVKERLWRADKEQA 810
RSGLVVEEDLFNTLPPEVKERLWRADKEQA
Sbjct: 781 RSGLVVEEDLFNTLPPEVKERLWRADKEQA 810
>gi|187829877 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 1635 bits (4234), Expect = 0.0
Identities = 810/810 (100%), Positives = 810/810 (100%)
Query: 1 MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCKWV 60
MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCKWV
Sbjct: 1 MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCKWV 60
Query: 61 TKDSCNDSFRGWAAPGPEPTYPNSTILPTPDTGPTGIKYDLDRHQYNYVDAVCYENRLHW 120
TKDSCNDSFRGWAAPGPEPTYPNSTILPTPDTGPTGIKYDLDRHQYNYVDAVCYENRLHW
Sbjct: 61 TKDSCNDSFRGWAAPGPEPTYPNSTILPTPDTGPTGIKYDLDRHQYNYVDAVCYENRLHW 120
Query: 121 FAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVEE 180
FAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVEE
Sbjct: 121 FAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVEE 180
Query: 181 SDPKPAFSKMNGSMDKKSSTVSEDVEATVPMLQRTKSRIEQGIVDRSETGVLDKKEGEQA 240
SDPKPAFSKMNGSMDKKSSTVSEDVEATVPMLQRTKSRIEQGIVDRSETGVLDKKEGEQA
Sbjct: 181 SDPKPAFSKMNGSMDKKSSTVSEDVEATVPMLQRTKSRIEQGIVDRSETGVLDKKEGEQA 240
Query: 241 KALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFILIICYTVYYVHNIKFDVDCTVDIE 300
KALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFILIICYTVYYVHNIKFDVDCTVDIE
Sbjct: 241 KALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFILIICYTVYYVHNIKFDVDCTVDIE 300
Query: 301 SLTGYRTYRCAHPLATLFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESIREES 360
SLTGYRTYRCAHPLATLFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESIREES
Sbjct: 301 SLTGYRTYRCAHPLATLFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESIREES 360
Query: 361 SYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQRL 420
SYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQRL
Sbjct: 361 SYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQRL 420
Query: 421 TKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTA 480
TKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTA
Sbjct: 421 TKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTA 480
Query: 481 AKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGL 540
AKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGL
Sbjct: 481 AKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGL 540
Query: 541 RELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIR 600
RELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIR
Sbjct: 541 RELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIR 600
Query: 601 CDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGN 660
CDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGN
Sbjct: 601 CDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGN 660
Query: 661 LTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRI 720
LTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRI
Sbjct: 661 LTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRI 720
Query: 721 ETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK 780
ETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK
Sbjct: 721 ETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK 780
Query: 781 RSGLVVEEDLFNTLPPEVKERLWRADKEQA 810
RSGLVVEEDLFNTLPPEVKERLWRADKEQA
Sbjct: 781 RSGLVVEEDLFNTLPPEVKERLWRADKEQA 810
>gi|187829871 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 1635 bits (4234), Expect = 0.0
Identities = 810/810 (100%), Positives = 810/810 (100%)
Query: 1 MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCKWV 60
MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCKWV
Sbjct: 1 MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCKWV 60
Query: 61 TKDSCNDSFRGWAAPGPEPTYPNSTILPTPDTGPTGIKYDLDRHQYNYVDAVCYENRLHW 120
TKDSCNDSFRGWAAPGPEPTYPNSTILPTPDTGPTGIKYDLDRHQYNYVDAVCYENRLHW
Sbjct: 61 TKDSCNDSFRGWAAPGPEPTYPNSTILPTPDTGPTGIKYDLDRHQYNYVDAVCYENRLHW 120
Query: 121 FAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVEE 180
FAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVEE
Sbjct: 121 FAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVEE 180
Query: 181 SDPKPAFSKMNGSMDKKSSTVSEDVEATVPMLQRTKSRIEQGIVDRSETGVLDKKEGEQA 240
SDPKPAFSKMNGSMDKKSSTVSEDVEATVPMLQRTKSRIEQGIVDRSETGVLDKKEGEQA
Sbjct: 181 SDPKPAFSKMNGSMDKKSSTVSEDVEATVPMLQRTKSRIEQGIVDRSETGVLDKKEGEQA 240
Query: 241 KALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFILIICYTVYYVHNIKFDVDCTVDIE 300
KALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFILIICYTVYYVHNIKFDVDCTVDIE
Sbjct: 241 KALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFILIICYTVYYVHNIKFDVDCTVDIE 300
Query: 301 SLTGYRTYRCAHPLATLFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESIREES 360
SLTGYRTYRCAHPLATLFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESIREES
Sbjct: 301 SLTGYRTYRCAHPLATLFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESIREES 360
Query: 361 SYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQRL 420
SYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQRL
Sbjct: 361 SYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQRL 420
Query: 421 TKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTA 480
TKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTA
Sbjct: 421 TKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTA 480
Query: 481 AKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGL 540
AKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGL
Sbjct: 481 AKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGL 540
Query: 541 RELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIR 600
RELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIR
Sbjct: 541 RELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIR 600
Query: 601 CDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGN 660
CDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGN
Sbjct: 601 CDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGN 660
Query: 661 LTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRI 720
LTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRI
Sbjct: 661 LTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRI 720
Query: 721 ETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK 780
ETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK
Sbjct: 721 ETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK 780
Query: 781 RSGLVVEEDLFNTLPPEVKERLWRADKEQA 810
RSGLVVEEDLFNTLPPEVKERLWRADKEQA
Sbjct: 781 RSGLVVEEDLFNTLPPEVKERLWRADKEQA 810
>gi|19923729 leucine rich repeat containing 8 family, member C [Homo
sapiens]
Length = 803
Score = 956 bits (2471), Expect = 0.0
Identities = 466/806 (57%), Positives = 614/806 (76%), Gaps = 10/806 (1%)
Query: 1 MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCKWV 60
MIPVTE R F++ QPA+R+LKPWWDVFTDY+S+ MLMI VFG TLQV QDK+ICLP +
Sbjct: 1 MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKR-- 58
Query: 61 TKDSCNDSFRGWAAPGPEPTYPNSTILPTPDTGPT----GIKYDLDRHQYNYVDAVCYEN 116
+ + N S + T P P+P T G+K DLD QY++++ +CYE
Sbjct: 59 VQPAQNHSSLSNVSQAVASTTPLPPPKPSPANPITVEMKGLKTDLDLQQYSFINQMCYER 118
Query: 117 RLHWFAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSET 176
LHW+AKYFPYLVL+HTL+F+ CSNFWFKFP +SSK+EHF+SIL KCFDSPWTTRALSE
Sbjct: 119 ALHWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFISILGKCFDSPWTTRALSEV 178
Query: 177 VVEESDPKPAFSKMNGSMDKKSSTVSEDVEATVPMLQRTKSRIEQGIVDRSETGVLDKKE 236
E+S+ K ++ N +S+T+ E ++ Q KS E+ +VD+S G LDKKE
Sbjct: 179 SGEDSEEKD--NRKNNM--NRSNTIQSGPEGSLVNSQSLKSIPEKFVVDKSTAGALDKKE 234
Query: 237 GEQAKALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFILIICYTVYYVHNIKFDVDCT 296
GEQAKALFEKVKKFR HVEEGDI+Y +Y+RQT++KVIKF++II Y V ++F VDC
Sbjct: 235 GEQAKALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCN 294
Query: 297 VDIESLTGYRTYRCAHPLATLFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESI 356
VDI+ +TGY+ + C H +A LF L+ Y+ V YGL C+YTL+W+ RSL++YSFE +
Sbjct: 295 VDIQDMTGYKNFSCNHTMAHLFSKLSFCYLCFVSIYGLTCLYTLYWLFYRSLREYSFEYV 354
Query: 357 REESSYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKL 416
R+E+ DIPDVKNDFAFMLH+IDQYDPLYSKRFAVFLSEVSENKL+QLNLNNEWT DKL
Sbjct: 355 RQETGIDDIPDVKNDFAFMLHMIDQYDPLYSKRFAVFLSEVSENKLKQLNLNNEWTPDKL 414
Query: 417 RQRLTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWL 476
RQ+L NA ++LEL L MLSG+PDTVF++ EL+ LKLE+I +V IP +IAQL L+EL L
Sbjct: 415 RQKLQTNAHNRLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSL 474
Query: 477 YHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIV 536
+ + KI + AL+FL+ENL+ L +KF D++E+P W+Y L+ LEEL+L G+LS + +R +
Sbjct: 475 HQCSVKIHSAALSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVT 534
Query: 537 IDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTEL 596
++ LR+LK LK+L +KSN+SK+PQ V DV HLQK+ I+N+GTKL++LN+LKKM NLTEL
Sbjct: 535 LESLRDLKSLKILSIKSNVSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTEL 594
Query: 597 ELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPI 656
EL+ CDLERIPH++FSL +LQE+DLK+NNLK+IEEI+SFQHL +LT LKLW+N I YIP
Sbjct: 595 ELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPE 654
Query: 657 QIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAIT 716
I LT+LERL + NKIE +P+ LF C K+RYLDLS+N++ F+P +IG+LQ+LQ +IT
Sbjct: 655 HIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSIT 714
Query: 717 ANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGEC 776
N++E+LP EL+ C+KL+ L +G N L L ++G L L+ ++++GN E LP ELG+C
Sbjct: 715 CNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDC 774
Query: 777 PLLKRSGLVVEEDLFNTLPPEVKERL 802
LKR+GLVVE+ LF TLP +V+E++
Sbjct: 775 RALKRAGLVVEDALFETLPSDVREQM 800
>gi|197333692 leucine rich repeat containing 8 family, member B
[Homo sapiens]
Length = 803
Score = 956 bits (2471), Expect = 0.0
Identities = 474/803 (59%), Positives = 612/803 (76%), Gaps = 8/803 (0%)
Query: 1 MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMIC-LPCKW 59
MI +TEL+ AD Q +Y ILKPWWDVF YI+++ML++AV G LQ+TQ +++C LPCK
Sbjct: 1 MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLCCLPCKV 60
Query: 60 VTKDSCNDSFRGWAAPGPEPTYPNSTILPTPDTGPTGIKYDLDRHQYNYVDAVCYENRLH 119
+ C + A + P TP P I+ DL R QY+Y+DAVCYE +LH
Sbjct: 61 EFDNHCAVPWDILKASMNTSSNPG-----TPLPLPLRIQNDLHRQQYSYIDAVCYEKQLH 115
Query: 120 WFAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVE 179
WFAK+FPYLVLLHTLIF ACSNFW +P TSS+LEHFV+IL KCFDSPWTTRALSETV E
Sbjct: 116 WFAKFFPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVAILHKCFDSPWTTRALSETVAE 175
Query: 180 ESDPKPAFSKMNGSMDKKSSTVSEDVEATVPMLQRTKSRIEQGIVDRSETGVLDKKEGEQ 239
+S SK + SS S D+++ L + +E ++ + VLDKKEGEQ
Sbjct: 176 QSVRPLKLSKSKILLS--SSGCSADIDSGKQSLPYPQPGLESAGIESPTSSVLDKKEGEQ 233
Query: 240 AKALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFILIICYTVYYVHNIKFDVDCTVDI 299
AKA+FEKVK+FR HVE+ DI+YR+Y++Q I+KVI F+LII Y Y++ +I ++DC+VD+
Sbjct: 234 AKAIFEKVKRFRMHVEQKDIIYRVYLKQIIVKVILFVLIITYVPYFLTHITLEIDCSVDV 293
Query: 300 ESLTGYRTYRCAHPLATLFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESIREE 359
++ TGY+ Y+C + LA +FK+LASFY+ LVI YGL Y+LWWMLR SLK+YSFE++RE+
Sbjct: 294 QAFTGYKRYQCVYSLAEIFKVLASFYVILVILYGLTSSYSLWWMLRSSLKQYSFEALREK 353
Query: 360 SSYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQR 419
S+YSDIPDVKNDFAF+LHL DQYDPLYSKRF++FLSEVSENKL+Q+NLNNEWT++KL+ +
Sbjct: 354 SNYSDIPDVKNDFAFILHLADQYDPLYSKRFSIFLSEVSENKLKQINLNNEWTVEKLKSK 413
Query: 420 LTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHT 479
L KNAQDK+ELHLFML+G+PD VF+L E+EVL LELIP+V +P +++QL LKEL +YH+
Sbjct: 414 LVKNAQDKIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHS 473
Query: 480 AAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDG 539
+ ++ PALAFL ENL+ L +KFT++ +IP W++ LK L+EL+L+G + E + ++G
Sbjct: 474 SLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEG 533
Query: 540 LRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELI 599
++LK L+ L LKS+LS++PQVVTD+ LQKLS++NEG+KL+VLN+LKKM NL LELI
Sbjct: 534 FQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELI 593
Query: 600 RCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIG 659
CDLERIPHSIFSL+NL E+DL++NNLKT+EEIISFQHL L+CLKLW+N+IAYIP QIG
Sbjct: 594 SCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIG 653
Query: 660 NLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANR 719
L+NLE+L L+ N IE +P QLF C KL YLDLS+N+LTF+P +I L NLQ A+T N
Sbjct: 654 ALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNN 713
Query: 720 IETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLL 779
IE LP LFQC+KL+ L LG N L +L VGEL+NLT +EL GN LE LP EL C L
Sbjct: 714 IEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSL 773
Query: 780 KRSGLVVEEDLFNTLPPEVKERL 802
KR+ L+VEE+L NTLP V ERL
Sbjct: 774 KRNCLIVEENLLNTLPLPVTERL 796
>gi|21245134 leucine rich repeat containing 8 family, member B [Homo
sapiens]
Length = 803
Score = 956 bits (2471), Expect = 0.0
Identities = 474/803 (59%), Positives = 612/803 (76%), Gaps = 8/803 (0%)
Query: 1 MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMIC-LPCKW 59
MI +TEL+ AD Q +Y ILKPWWDVF YI+++ML++AV G LQ+TQ +++C LPCK
Sbjct: 1 MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLCCLPCKV 60
Query: 60 VTKDSCNDSFRGWAAPGPEPTYPNSTILPTPDTGPTGIKYDLDRHQYNYVDAVCYENRLH 119
+ C + A + P TP P I+ DL R QY+Y+DAVCYE +LH
Sbjct: 61 EFDNHCAVPWDILKASMNTSSNPG-----TPLPLPLRIQNDLHRQQYSYIDAVCYEKQLH 115
Query: 120 WFAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVE 179
WFAK+FPYLVLLHTLIF ACSNFW +P TSS+LEHFV+IL KCFDSPWTTRALSETV E
Sbjct: 116 WFAKFFPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVAILHKCFDSPWTTRALSETVAE 175
Query: 180 ESDPKPAFSKMNGSMDKKSSTVSEDVEATVPMLQRTKSRIEQGIVDRSETGVLDKKEGEQ 239
+S SK + SS S D+++ L + +E ++ + VLDKKEGEQ
Sbjct: 176 QSVRPLKLSKSKILLS--SSGCSADIDSGKQSLPYPQPGLESAGIESPTSSVLDKKEGEQ 233
Query: 240 AKALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFILIICYTVYYVHNIKFDVDCTVDI 299
AKA+FEKVK+FR HVE+ DI+YR+Y++Q I+KVI F+LII Y Y++ +I ++DC+VD+
Sbjct: 234 AKAIFEKVKRFRMHVEQKDIIYRVYLKQIIVKVILFVLIITYVPYFLTHITLEIDCSVDV 293
Query: 300 ESLTGYRTYRCAHPLATLFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESIREE 359
++ TGY+ Y+C + LA +FK+LASFY+ LVI YGL Y+LWWMLR SLK+YSFE++RE+
Sbjct: 294 QAFTGYKRYQCVYSLAEIFKVLASFYVILVILYGLTSSYSLWWMLRSSLKQYSFEALREK 353
Query: 360 SSYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQR 419
S+YSDIPDVKNDFAF+LHL DQYDPLYSKRF++FLSEVSENKL+Q+NLNNEWT++KL+ +
Sbjct: 354 SNYSDIPDVKNDFAFILHLADQYDPLYSKRFSIFLSEVSENKLKQINLNNEWTVEKLKSK 413
Query: 420 LTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHT 479
L KNAQDK+ELHLFML+G+PD VF+L E+EVL LELIP+V +P +++QL LKEL +YH+
Sbjct: 414 LVKNAQDKIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHS 473
Query: 480 AAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDG 539
+ ++ PALAFL ENL+ L +KFT++ +IP W++ LK L+EL+L+G + E + ++G
Sbjct: 474 SLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEG 533
Query: 540 LRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELI 599
++LK L+ L LKS+LS++PQVVTD+ LQKLS++NEG+KL+VLN+LKKM NL LELI
Sbjct: 534 FQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELI 593
Query: 600 RCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIG 659
CDLERIPHSIFSL+NL E+DL++NNLKT+EEIISFQHL L+CLKLW+N+IAYIP QIG
Sbjct: 594 SCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIG 653
Query: 660 NLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANR 719
L+NLE+L L+ N IE +P QLF C KL YLDLS+N+LTF+P +I L NLQ A+T N
Sbjct: 654 ALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNN 713
Query: 720 IETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLL 779
IE LP LFQC+KL+ L LG N L +L VGEL+NLT +EL GN LE LP EL C L
Sbjct: 714 IEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSL 773
Query: 780 KRSGLVVEEDLFNTLPPEVKERL 802
KR+ L+VEE+L NTLP V ERL
Sbjct: 774 KRNCLIVEENLLNTLPLPVTERL 796
>gi|197333706 leucine rich repeat containing 8 family, member D
[Homo sapiens]
Length = 858
Score = 926 bits (2392), Expect = 0.0
Identities = 460/846 (54%), Positives = 612/846 (72%), Gaps = 44/846 (5%)
Query: 1 MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPC--- 57
M + E+ D QP YRILKPWWDVF DY+++VMLM+A+F GT+Q+T+D+++CLP
Sbjct: 1 MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPS 60
Query: 58 ------------KWVTKD---------------SCNDSFRGWAAPGPE----PTYPNSTI 86
VT + + ND G +A P+ TYP +
Sbjct: 61 PVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDF 120
Query: 87 -LPTPDT-----GPTGIKYDLDRHQYNYVDAVCYENRLHWFAKYFPYLVLLHTLIFLACS 140
LP + PTG K +LD QY +++ +CY L W++KYFPYL L+HT+I + S
Sbjct: 121 ALPNQEAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSS 180
Query: 141 NFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVEESDPKPAFSKMNGSMDKKSST 200
NFWFK+P+T SK+EHFVSIL KCF+SPWTT+ALSET E+S+ ++ K ST
Sbjct: 181 NFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVST 240
Query: 201 VSED--VEATVPMLQRT--KSRIEQGIVDRSETGVLDKKEGEQAKALFEKVKKFRTHVEE 256
S++ A+ PM+ +T K E+ +++ +LDKK+GEQAKALFEKV+KFR HVE+
Sbjct: 241 SSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVED 300
Query: 257 GDIVYRLYMRQTIIKVIKFILIICYTVYYVHNIKFDVDCTVDIESLTGYRTYRCAHPLAT 316
D++Y+LY+ QT+IK KFI I+CYT +V+ I F+ C +E L GY + C H +A
Sbjct: 301 SDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAY 360
Query: 317 LFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESIREESSYSDIPDVKNDFAFML 376
+ K L YIS++ YG IC+YTL+W+ R LK+YSFE +REESS+SDIPDVKNDFAF+L
Sbjct: 361 MLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLL 420
Query: 377 HLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQRLTKNAQDKLELHLFMLS 436
H++DQYD LYSKRF VFLSEVSENKLR+++LN+EWT +KLRQ +++NAQDK ELHLFMLS
Sbjct: 421 HMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLS 480
Query: 437 GIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLR 496
G+PD VFDL +L+VLKLELIP+ IP I+Q+T L+EL L H AK+E A +FLR++LR
Sbjct: 481 GVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLR 540
Query: 497 ALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLS 556
LH+KFTD+ EIP W+Y LK L EL+L GNL++ENN+ I ++ LREL+ LK+L +KSNL+
Sbjct: 541 CLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLT 600
Query: 557 KLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNL 616
K+P +TDV HL KL I+N+GTKL+VLNSLKKM N+ ELEL C+LERIPH+IFSL NL
Sbjct: 601 KVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNL 660
Query: 617 QEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEK 676
QE+DLK NN++TIEEIISFQHL RLTCLKLW+N I IP I ++ NLE LY + NK+E
Sbjct: 661 QELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLES 720
Query: 677 IPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRAL 736
+P +F +KLR LD+S+NN++ +P +IGLLQNLQ+L IT N+++ LP +LF+C KLR L
Sbjct: 721 LPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTL 780
Query: 737 HLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPP 796
+LG N + SLP +VG+L+ LTQ+EL+GN L+ LP +LG+C +LK+SGLVVE+ LF+TLP
Sbjct: 781 NLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPL 840
Query: 797 EVKERL 802
EVKE L
Sbjct: 841 EVKEAL 846
>gi|34222199 leucine rich repeat containing 8 family, member D [Homo
sapiens]
Length = 858
Score = 926 bits (2392), Expect = 0.0
Identities = 460/846 (54%), Positives = 612/846 (72%), Gaps = 44/846 (5%)
Query: 1 MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPC--- 57
M + E+ D QP YRILKPWWDVF DY+++VMLM+A+F GT+Q+T+D+++CLP
Sbjct: 1 MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPS 60
Query: 58 ------------KWVTKD---------------SCNDSFRGWAAPGPE----PTYPNSTI 86
VT + + ND G +A P+ TYP +
Sbjct: 61 PVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDF 120
Query: 87 -LPTPDT-----GPTGIKYDLDRHQYNYVDAVCYENRLHWFAKYFPYLVLLHTLIFLACS 140
LP + PTG K +LD QY +++ +CY L W++KYFPYL L+HT+I + S
Sbjct: 121 ALPNQEAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSS 180
Query: 141 NFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVEESDPKPAFSKMNGSMDKKSST 200
NFWFK+P+T SK+EHFVSIL KCF+SPWTT+ALSET E+S+ ++ K ST
Sbjct: 181 NFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVST 240
Query: 201 VSED--VEATVPMLQRT--KSRIEQGIVDRSETGVLDKKEGEQAKALFEKVKKFRTHVEE 256
S++ A+ PM+ +T K E+ +++ +LDKK+GEQAKALFEKV+KFR HVE+
Sbjct: 241 SSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVED 300
Query: 257 GDIVYRLYMRQTIIKVIKFILIICYTVYYVHNIKFDVDCTVDIESLTGYRTYRCAHPLAT 316
D++Y+LY+ QT+IK KFI I+CYT +V+ I F+ C +E L GY + C H +A
Sbjct: 301 SDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAY 360
Query: 317 LFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESIREESSYSDIPDVKNDFAFML 376
+ K L YIS++ YG IC+YTL+W+ R LK+YSFE +REESS+SDIPDVKNDFAF+L
Sbjct: 361 MLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLL 420
Query: 377 HLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQRLTKNAQDKLELHLFMLS 436
H++DQYD LYSKRF VFLSEVSENKLR+++LN+EWT +KLRQ +++NAQDK ELHLFMLS
Sbjct: 421 HMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLS 480
Query: 437 GIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLR 496
G+PD VFDL +L+VLKLELIP+ IP I+Q+T L+EL L H AK+E A +FLR++LR
Sbjct: 481 GVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLR 540
Query: 497 ALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLS 556
LH+KFTD+ EIP W+Y LK L EL+L GNL++ENN+ I ++ LREL+ LK+L +KSNL+
Sbjct: 541 CLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLT 600
Query: 557 KLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNL 616
K+P +TDV HL KL I+N+GTKL+VLNSLKKM N+ ELEL C+LERIPH+IFSL NL
Sbjct: 601 KVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNL 660
Query: 617 QEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEK 676
QE+DLK NN++TIEEIISFQHL RLTCLKLW+N I IP I ++ NLE LY + NK+E
Sbjct: 661 QELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLES 720
Query: 677 IPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRAL 736
+P +F +KLR LD+S+NN++ +P +IGLLQNLQ+L IT N+++ LP +LF+C KLR L
Sbjct: 721 LPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTL 780
Query: 737 HLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPP 796
+LG N + SLP +VG+L+ LTQ+EL+GN L+ LP +LG+C +LK+SGLVVE+ LF+TLP
Sbjct: 781 NLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPL 840
Query: 797 EVKERL 802
EVKE L
Sbjct: 841 EVKEAL 846
>gi|40217803 leucine rich repeat containing 8 family, member E [Homo
sapiens]
Length = 796
Score = 858 bits (2218), Expect = 0.0
Identities = 430/803 (53%), Positives = 573/803 (71%), Gaps = 11/803 (1%)
Query: 1 MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCKWV 60
MIPV E + F + QPA+++LKPWWDV +Y+++ MLMI VFG TLQVTQDK+ICLP +
Sbjct: 1 MIPVAEFKQFTEQQPAFKVLKPWWDVLAEYLTVAMLMIGVFGCTLQVTQDKIICLPNHEL 60
Query: 61 TKDSCNDSFRGWAAPG-PEPTYPNSTILPTPDTGPTGIKYDLDRHQYNYVDAVCYENRLH 119
++ + G PE + G+K +LD QY++++ +CYE LH
Sbjct: 61 QENLSEAPCQQLLPRGIPEQIGALQEV--------KGLKNNLDLQQYSFINQLCYETALH 112
Query: 120 WFAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVE 179
W+AKYFPYLV++HTLIF+ C++FWFKFP TSSK+EHF+SIL KCFDSPWTTRALSE E
Sbjct: 113 WYAKYFPYLVVIHTLIFMVCTSFWFKFPGTSSKIEHFISILGKCFDSPWTTRALSEVSGE 172
Query: 180 ESDPKPAFSKMNGSMDKKSSTVSEDVEATVPMLQRTKSRIEQGIVDRSETGVLDKKEGEQ 239
A + ++ + T +A ++ + E+ + + +LDKKEGEQ
Sbjct: 173 NQKGPAATERAAATIVAMAGTGPG--KAGEGEKEKVLAEPEKVVTEPPVVTLLDKKEGEQ 230
Query: 240 AKALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFILIICYTVYYVHNIKFDVDCTVDI 299
AKALFEKVKKFR HVEEGDI+Y +Y+RQT++KV KF+ I+ Y + YV I F V C V+
Sbjct: 231 AKALFEKVKKFRMHVEEGDILYTMYIRQTVLKVCKFLAILVYNLVYVEKISFLVACRVET 290
Query: 300 ESLTGYRTYRCAHPLATLFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESIREE 359
+TGY ++ C H A LF LA YIS V YGL C+YTL+W+ R LK+YSF S+REE
Sbjct: 291 SEVTGYASFCCNHTKAHLFSKLAFCYISFVCIYGLTCIYTLYWLFHRPLKEYSFRSVREE 350
Query: 360 SSYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQR 419
+ DIPDVKNDFAFMLHLIDQYD LYSKRFAVFLSEVSE++L+QLNLN+EWT +KLRQ+
Sbjct: 351 TGMGDIPDVKNDFAFMLHLIDQYDSLYSKRFAVFLSEVSESRLKQLNLNHEWTPEKLRQK 410
Query: 420 LTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHT 479
L +NA +LEL L ML G+PDTVF+L E+E L+LE I D+T PP ++QL L+EL L H+
Sbjct: 411 LQRNAAGRLELALCMLPGLPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHS 470
Query: 480 AAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDG 539
A++ FLR++L+ + +K +++E+PLW++ L+ LEELHL G E R ++
Sbjct: 471 PARLPFSLQVFLRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLES 530
Query: 540 LRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELI 599
LRELK+LKVL L+SN K+P VTDV HLQ+LS++N+G +L+ LNSLKK+A L ELEL+
Sbjct: 531 LRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELV 590
Query: 600 RCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIG 659
C LERIPH++FSL LQE+DLKDN+L++IEEI+SFQH +L L+LW+N IAY+P +
Sbjct: 591 ACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVR 650
Query: 660 NLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANR 719
L +LE+LYL+ NK+E +P+QL C LR LD+SHN L LP ++GLLQNLQ+LA++ N
Sbjct: 651 KLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNA 710
Query: 720 IETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLL 779
+E LP ELF CRKLR L LG+N L L VG L L+++EL+GNRLE LP ELG C L
Sbjct: 711 LEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGL 770
Query: 780 KRSGLVVEEDLFNTLPPEVKERL 802
K++GL+VE+ L+ LP EV++++
Sbjct: 771 KKAGLLVEDTLYQGLPAEVRDKM 793
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 130 bits (326), Expect = 6e-30
Identities = 128/425 (30%), Positives = 193/425 (45%), Gaps = 40/425 (9%)
Query: 397 VSENKLRQL--NLNNEWTLDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLE 454
+SEN L L +L+N L KLR L+L L IP V+ L L L L
Sbjct: 153 LSENSLTSLPDSLDN---LKKLRM---------LDLRHNKLREIPSVVYRLDSLTTLYLR 200
Query: 455 LIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYS 514
T+ I L+ L L + K + PA NL L + ++ +P I +
Sbjct: 201 FNRITTVEKDIKNLSKLSMLSIRENKIK-QLPAEIGELCNLITLDVAHNQLEHLPKEIGN 259
Query: 515 LKTLEELHLT-----------GNLSAEN------NRYIVID-GLRELKRLKVLRLKSN-L 555
+ L L GNLS+ + NR I L + L+ L L++N +
Sbjct: 260 CTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNI 319
Query: 556 SKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHN 615
S LP+ + V L L++ +L + + + + L + + +IP IFS
Sbjct: 320 STLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAK 379
Query: 616 -LQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKI 674
L ++++KDN L ++ + F + L L N + IP + L +LE L L+ N +
Sbjct: 380 VLSKLNMKDNQLTSLP--LDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLL 437
Query: 675 EKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLR 734
+K+P L RKLR LDL N L LP +I L++LQ L +T N++ TLP + L
Sbjct: 438 KKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLT 497
Query: 735 ALHLGNNVLQSLPSRVGELTNLTQIELRGN-RLECLPVELGECPLLKRSGLVVEEDLFNT 793
L LG N+L LP +G L NL ++ L N L LP EL C K S + +E +
Sbjct: 498 HLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCS--KLSIMSIENCPLSH 555
Query: 794 LPPEV 798
LPP++
Sbjct: 556 LPPQI 560
Score = 117 bits (294), Expect = 3e-26
Identities = 74/221 (33%), Positives = 120/221 (54%), Gaps = 4/221 (1%)
Query: 582 IVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRL 641
I+ +S+K++ LTEL L L+ +P + L NL + L +N+L ++ + S +L +L
Sbjct: 114 ILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPD--SLDNLKKL 171
Query: 642 TCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLP 701
L L +N + IP + L +L LYL N+I + + KL L + N + LP
Sbjct: 172 RMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLP 231
Query: 702 ADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIEL 761
A+IG L NL L + N++E LP E+ C ++ L L +N L LP +G L++L+++ L
Sbjct: 232 AEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGL 291
Query: 762 RGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEVKERL 802
R NRL +P L +C L+ L +E + +TLP + L
Sbjct: 292 RYNRLSAIPRSLAKCSALEE--LNLENNNISTLPESLLSSL 330
Score = 109 bits (273), Expect = 9e-24
Identities = 104/385 (27%), Positives = 178/385 (46%), Gaps = 62/385 (16%)
Query: 461 IPPSIAQLTGLKELWLY---------HTAAKIEAPALAFLREN--------------LRA 497
+P SI +LT L EL+LY + LA L EN LR
Sbjct: 115 LPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLA-LSENSLTSLPDSLDNLKKLRM 173
Query: 498 LHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVID-GLRELKRLKVLRLKSNLS 556
L ++ ++EIP +Y L +L L+L NR ++ ++ L +L +L ++ N
Sbjct: 174 LDLRHNKLREIPSVVYRLDSLTTLYL------RFNRITTVEKDIKNLSKLSMLSIREN-- 225
Query: 557 KLPQVVTDVG---------------VHLQK--------LSINNEGTKLIVL-NSLKKMAN 592
K+ Q+ ++G HL K +++ + +L+ L +++ +++
Sbjct: 226 KIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSS 285
Query: 593 LTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIA 652
L+ L L L IP S+ L+E++L++NN+ T+ E + L +L L L N
Sbjct: 286 LSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESL-LSSLVKLNSLTLARNCFQ 344
Query: 653 YIPI-QIGNLTNLERLYLNRNKIEKIPTQLFYCRK-LRYLDLSHNNLTFLPADIGLLQNL 710
P+ + + L + N+I KIP +F K L L++ N LT LP D G ++
Sbjct: 345 LYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSM 404
Query: 711 QNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLP 770
L + N++ +P ++ L L L NN+L+ LP +G L L +++L N+LE LP
Sbjct: 405 VELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLP 464
Query: 771 VELGECPLLKRSGLVVEEDLFNTLP 795
E+ L++ LV+ + TLP
Sbjct: 465 NEIAYLKDLQK--LVLTNNQLTTLP 487
Score = 99.8 bits (247), Expect = 9e-21
Identities = 56/162 (34%), Positives = 89/162 (54%), Gaps = 2/162 (1%)
Query: 615 NLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKI 674
N +DL ++ + S + L +LT L L+ N + +P ++G L NL L L+ N +
Sbjct: 101 NSMRLDLSKRSIHILPS--SIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSL 158
Query: 675 EKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLR 734
+P L +KLR LDL HN L +P+ + L +L L + NRI T+ ++ KL
Sbjct: 159 TSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLS 218
Query: 735 ALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGEC 776
L + N ++ LP+ +GEL NL +++ N+LE LP E+G C
Sbjct: 219 MLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNC 260
Score = 43.5 bits (101), Expect = 8e-04
Identities = 26/73 (35%), Positives = 37/73 (50%)
Query: 708 QNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLE 767
+N L ++ I LP + + +L L+L +N LQSLP+ VG L NL + L N L
Sbjct: 100 ENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLT 159
Query: 768 CLPVELGECPLLK 780
LP L L+
Sbjct: 160 SLPDSLDNLKKLR 172
>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
sapiens]
Length = 560
Score = 124 bits (312), Expect = 3e-28
Identities = 89/263 (33%), Positives = 137/263 (52%), Gaps = 29/263 (11%)
Query: 508 IPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGV 567
IPL I++ LEE+HL ENN+ I +E++RLK +R+ +
Sbjct: 40 IPLEIFTFTELEEVHL------ENNQIEEIP--QEIQRLKNIRV---------------L 76
Query: 568 HLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLK 627
+L K ++ + L +L+SL+ + +L+ + L + LH L+E+ L +LK
Sbjct: 77 YLDKNNLRSLCPALGLLSSLESL-DLSYNPIFSSSLVVVSF----LHALRELRLYQTDLK 131
Query: 628 TIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKL 687
I +I F++LH L L L NH+ +P +I N T L +YL RN+ E P +L L
Sbjct: 132 EIPVVI-FKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTL 190
Query: 688 RYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLP 747
+DL N + +P +IG L LQ + +N + LP L QC +L L L +N+L S+P
Sbjct: 191 EIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIP 250
Query: 748 SRVGELTNLTQIELRGNRLECLP 770
EL +T+I L GNRLE +P
Sbjct: 251 KSFAELRKMTEIGLSGNRLEKVP 273
Score = 117 bits (292), Expect = 6e-26
Identities = 120/429 (27%), Positives = 192/429 (44%), Gaps = 73/429 (17%)
Query: 435 LSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRE- 493
L+ IP +F ELE + LE IP I +L ++ L+L + PAL L
Sbjct: 37 LTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPALGLLSSL 96
Query: 494 ----------------------NLRALHIKFTDIKEIPLWIY-SLKTLEELHLTGN---- 526
LR L + TD+KEIP+ I+ +L LE L LTGN
Sbjct: 97 ESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKC 156
Query: 527 -------------LSAENNRYIVI-DGLRELKRLKVLRLKSNLSKLPQVVTDVG--VHLQ 570
+ + N++ V L L L+++ L N K+ + ++G LQ
Sbjct: 157 LPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDEN--KIGAIPEEIGHLTGLQ 214
Query: 571 KLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIE 630
K + + ++ SL + + L+ L+L L IP S L + EI L N L+ +
Sbjct: 215 KFYMASNNLPVLPA-SLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVP 273
Query: 631 EII---------------------SFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYL 669
+I SF+ L L L L NH+ + P+QI L NLE L L
Sbjct: 274 RLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGL 333
Query: 670 NRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITAN---RIETLPPE 726
+ NKI ++P++L KL+ L L+ N P ++ L +L+ L I + ++ +P
Sbjct: 334 DDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEH 393
Query: 727 LFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVV 786
+ + + L+ L++ NN L+ LP +G + NL ++ R N L+ LP + + LK L +
Sbjct: 394 IRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKE--LRL 451
Query: 787 EEDLFNTLP 795
E++L LP
Sbjct: 452 EDNLLTHLP 460
Score = 101 bits (251), Expect = 3e-21
Identities = 99/375 (26%), Positives = 173/375 (46%), Gaps = 30/375 (8%)
Query: 423 NAQDKLELHLFMLSGIPDTVF-DLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAA 481
+A +L L+ L IP +F +L LE+L L +P I T L+E++L
Sbjct: 118 HALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQF 177
Query: 482 KIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGN--------------L 527
++ L L L + + I IP I L L++ ++ N L
Sbjct: 178 EVFPQELCVLY-TLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQL 236
Query: 528 S----AENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQVVTD-VGVHLQKLSINNEGTKL 581
S + N + + EL+++ + L N L K+P+++ +HL L + N G
Sbjct: 237 SVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHL--LYLGNTGLHR 294
Query: 582 IVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRL 641
+ S + + NL L+L + L P I +L NL+ + L DN + + + L +L
Sbjct: 295 L-RGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELG--SLSKL 351
Query: 642 TCLKLWYNHIAYIPIQIGNLTNLERLYLNRN---KIEKIPTQLFYCRKLRYLDLSHNNLT 698
L L N P ++ +L +LE+LY+ ++ K+ +P + + L+ L + +N+L
Sbjct: 352 KILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLE 411
Query: 699 FLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQ 758
+LP +G + NL+ L N ++ LP + Q + L+ L L +N+L LP + L NL
Sbjct: 412 YLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKV 471
Query: 759 IELRGNRLECLPVEL 773
+ L N +E P E+
Sbjct: 472 LTLMDNPMEEPPKEV 486
Score = 48.9 bits (115), Expect = 2e-05
Identities = 24/76 (31%), Positives = 46/76 (60%)
Query: 689 YLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPS 748
++D S+ +LT +P +I L+ + + N+IE +P E+ + + +R L+L N L+SL
Sbjct: 29 FIDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCP 88
Query: 749 RVGELTNLTQIELRGN 764
+G L++L ++L N
Sbjct: 89 ALGLLSSLESLDLSYN 104
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 121 bits (304), Expect = 2e-27
Identities = 98/316 (31%), Positives = 160/316 (50%), Gaps = 12/316 (3%)
Query: 484 EAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLREL 543
E P F NLR L + +I+ +P + + L EL ++ N E + + ++
Sbjct: 50 ELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPE-----IPESIKFC 104
Query: 544 KRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCD 602
K L++ N LS+LP T + L L++N+ + + + +ANL LEL
Sbjct: 105 KALEIADFSGNPLSRLPDGFTQLR-SLAHLALNDVSLQALP-GDVGNLANLVTLELRENL 162
Query: 603 LERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLT 662
L+ +P S+ L L+++DL N+L+ + + + L L L L N ++ +P ++GNL
Sbjct: 163 LKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGA--LPNLRELWLDRNQLSALPPELGNLR 220
Query: 663 NLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIET 722
L L ++ N++E++P +L L L LS N L LP IG L+ L L + NR+
Sbjct: 221 RLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCE 280
Query: 723 LPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRS 782
+ + C L L L N+L +LP +G+LT LT + + N LE LP E+G C L S
Sbjct: 281 VTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVAL--S 338
Query: 783 GLVVEEDLFNTLPPEV 798
L + ++ LPPE+
Sbjct: 339 VLSLRDNRLAVLPPEL 354
Score = 112 bits (280), Expect = 1e-24
Identities = 105/364 (28%), Positives = 163/364 (44%), Gaps = 35/364 (9%)
Query: 435 LSGIPDTVFDLVE-LEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRE 493
L +P+ ++ LE L L+ +P +L L++L L + P +A +
Sbjct: 24 LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83
Query: 494 NLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKS 553
L L + DI EIP I K LE +GN + + DG +L+ L L L
Sbjct: 84 -LVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSR-----LPDGFTQLRSLAHLALND 137
Query: 554 -NLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFS 612
+L LP V ++ +L L + K + SL + L +L+L DLE +P ++ +
Sbjct: 138 VSLQALPGDVGNLA-NLVTLELRENLLKSLPA-SLSFLVKLEQLDLGGNDLEVLPDTLGA 195
Query: 613 LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRN 672
L NL+E+ L N L + + +L RL CL + N + +P ++G L L L L++N
Sbjct: 196 LPNLRELWLDRNQLSALPPELG--NLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN 253
Query: 673 KIEKIPTQLFY-----------------------CRKLRYLDLSHNNLTFLPADIGLLQN 709
+ ++P + C L L L+ N L LP +G L
Sbjct: 254 LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTK 313
Query: 710 LQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECL 769
L NL + N +E LPPE+ C L L L +N L LP + T L +++ GNRL+ L
Sbjct: 314 LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSL 373
Query: 770 PVEL 773
P L
Sbjct: 374 PFAL 377
Score = 104 bits (260), Expect = 3e-22
Identities = 84/274 (30%), Positives = 136/274 (49%), Gaps = 14/274 (5%)
Query: 505 IKEIPLWIYS--LKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQV 561
+K IPLW + ++++++ H + E + R + L+ L L +N L +LP+
Sbjct: 2 LKCIPLWRCNRHVESVDKRHCSLQAVPE-------EIYRYSRSLEELLLDANQLRELPKP 54
Query: 562 VTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDL 621
+ ++L+KL +++ + + + L EL++ R D+ IP SI L+ D
Sbjct: 55 FFRL-LNLRKLGLSDNEIQRLP-PEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADF 112
Query: 622 KDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQL 681
N L + + F L L L L + +P +GNL NL L L N ++ +P L
Sbjct: 113 SGNPLSRLPD--GFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASL 170
Query: 682 FYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNN 741
+ KL LDL N+L LP +G L NL+ L + N++ LPPEL R+L L + N
Sbjct: 171 SFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSEN 230
Query: 742 VLQSLPSRVGELTNLTQIELRGNRLECLPVELGE 775
L+ LP+ +G L LT + L N L LP +G+
Sbjct: 231 RLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQ 264
Score = 100 bits (248), Expect = 7e-21
Identities = 66/199 (33%), Positives = 105/199 (52%), Gaps = 5/199 (2%)
Query: 601 CDLERIPHSIFSL-HNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIG 659
C L+ +P I+ +L+E+ L N L+ + + F L L L L N I +P ++
Sbjct: 22 CSLQAVPEEIYRYSRSLEELLLDANQLRELPK--PFFRLLNLRKLGLSDNEIQRLPPEVA 79
Query: 660 NLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANR 719
N L L ++RN I +IP + +C+ L D S N L+ LP L++L +LA+
Sbjct: 80 NFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVS 139
Query: 720 IETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLL 779
++ LP ++ L L L N+L+SLP+ + L L Q++L GN LE LP LG P L
Sbjct: 140 LQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNL 199
Query: 780 KRSGLVVEEDLFNTLPPEV 798
+ L ++ + + LPPE+
Sbjct: 200 RE--LWLDRNQLSALPPEL 216
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 121 bits (304), Expect = 2e-27
Identities = 98/316 (31%), Positives = 160/316 (50%), Gaps = 12/316 (3%)
Query: 484 EAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLREL 543
E P F NLR L + +I+ +P + + L EL ++ N E + + ++
Sbjct: 50 ELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPE-----IPESIKFC 104
Query: 544 KRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCD 602
K L++ N LS+LP T + L L++N+ + + + +ANL LEL
Sbjct: 105 KALEIADFSGNPLSRLPDGFTQLR-SLAHLALNDVSLQALP-GDVGNLANLVTLELRENL 162
Query: 603 LERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLT 662
L+ +P S+ L L+++DL N+L+ + + + L L L L N ++ +P ++GNL
Sbjct: 163 LKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGA--LPNLRELWLDRNQLSALPPELGNLR 220
Query: 663 NLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIET 722
L L ++ N++E++P +L L L LS N L LP IG L+ L L + NR+
Sbjct: 221 RLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCE 280
Query: 723 LPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRS 782
+ + C L L L N+L +LP +G+LT LT + + N LE LP E+G C L S
Sbjct: 281 VTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVAL--S 338
Query: 783 GLVVEEDLFNTLPPEV 798
L + ++ LPPE+
Sbjct: 339 VLSLRDNRLAVLPPEL 354
Score = 112 bits (280), Expect = 1e-24
Identities = 105/364 (28%), Positives = 163/364 (44%), Gaps = 35/364 (9%)
Query: 435 LSGIPDTVFDLVE-LEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRE 493
L +P+ ++ LE L L+ +P +L L++L L + P +A +
Sbjct: 24 LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83
Query: 494 NLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKS 553
L L + DI EIP I K LE +GN + + DG +L+ L L L
Sbjct: 84 -LVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSR-----LPDGFTQLRSLAHLALND 137
Query: 554 -NLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFS 612
+L LP V ++ +L L + K + SL + L +L+L DLE +P ++ +
Sbjct: 138 VSLQALPGDVGNLA-NLVTLELRENLLKSLPA-SLSFLVKLEQLDLGGNDLEVLPDTLGA 195
Query: 613 LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRN 672
L NL+E+ L N L + + +L RL CL + N + +P ++G L L L L++N
Sbjct: 196 LPNLRELWLDRNQLSALPPELG--NLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN 253
Query: 673 KIEKIPTQLFY-----------------------CRKLRYLDLSHNNLTFLPADIGLLQN 709
+ ++P + C L L L+ N L LP +G L
Sbjct: 254 LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTK 313
Query: 710 LQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECL 769
L NL + N +E LPPE+ C L L L +N L LP + T L +++ GNRL+ L
Sbjct: 314 LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSL 373
Query: 770 PVEL 773
P L
Sbjct: 374 PFAL 377
Score = 104 bits (260), Expect = 3e-22
Identities = 84/274 (30%), Positives = 136/274 (49%), Gaps = 14/274 (5%)
Query: 505 IKEIPLWIYS--LKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQV 561
+K IPLW + ++++++ H + E + R + L+ L L +N L +LP+
Sbjct: 2 LKCIPLWRCNRHVESVDKRHCSLQAVPE-------EIYRYSRSLEELLLDANQLRELPKP 54
Query: 562 VTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDL 621
+ ++L+KL +++ + + + L EL++ R D+ IP SI L+ D
Sbjct: 55 FFRL-LNLRKLGLSDNEIQRLP-PEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADF 112
Query: 622 KDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQL 681
N L + + F L L L L + +P +GNL NL L L N ++ +P L
Sbjct: 113 SGNPLSRLPD--GFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASL 170
Query: 682 FYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNN 741
+ KL LDL N+L LP +G L NL+ L + N++ LPPEL R+L L + N
Sbjct: 171 SFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSEN 230
Query: 742 VLQSLPSRVGELTNLTQIELRGNRLECLPVELGE 775
L+ LP+ +G L LT + L N L LP +G+
Sbjct: 231 RLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQ 264
Score = 100 bits (248), Expect = 7e-21
Identities = 66/199 (33%), Positives = 105/199 (52%), Gaps = 5/199 (2%)
Query: 601 CDLERIPHSIFSL-HNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIG 659
C L+ +P I+ +L+E+ L N L+ + + F L L L L N I +P ++
Sbjct: 22 CSLQAVPEEIYRYSRSLEELLLDANQLRELPK--PFFRLLNLRKLGLSDNEIQRLPPEVA 79
Query: 660 NLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANR 719
N L L ++RN I +IP + +C+ L D S N L+ LP L++L +LA+
Sbjct: 80 NFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVS 139
Query: 720 IETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLL 779
++ LP ++ L L L N+L+SLP+ + L L Q++L GN LE LP LG P L
Sbjct: 140 LQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNL 199
Query: 780 KRSGLVVEEDLFNTLPPEV 798
+ L ++ + + LPPE+
Sbjct: 200 RE--LWLDRNQLSALPPEL 216
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 119 bits (297), Expect = 1e-26
Identities = 99/341 (29%), Positives = 162/341 (47%), Gaps = 35/341 (10%)
Query: 459 VTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTL 518
V +P I + E L E P F LR L + +I+ +P I + L
Sbjct: 25 VYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQL 84
Query: 519 EELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNE 577
EL ++ N E + + + K L+V N L++LP+
Sbjct: 85 VELDVSRNEIPE-----IPESISFCKALQVADFSGNPLTRLPE----------------- 122
Query: 578 GTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQH 637
S ++ NLT L + L+ +P +I +L+NL ++L++N L + + S
Sbjct: 123 --------SFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPD--SLTQ 172
Query: 638 LHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNL 697
L RL L L N I +P IG L +L+ L+L+ N++ ++P ++ + L LD+S N L
Sbjct: 173 LRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRL 232
Query: 698 TFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLT 757
LP +I L +L +L I+ N +ET+P + + +KL L + N L LP VGE +LT
Sbjct: 233 ERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLT 292
Query: 758 QIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEV 798
++ L N+L LP +G+ L K S L + + +LP E+
Sbjct: 293 ELVLTENQLLTLPKSIGK--LKKLSNLNADRNKLVSLPKEI 331
Score = 118 bits (295), Expect = 3e-26
Identities = 97/340 (28%), Positives = 167/340 (49%), Gaps = 12/340 (3%)
Query: 438 IPDTVFDLVE-LEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLR 496
+P+ ++ LE L L+ +P QL L++L L + P +A + L
Sbjct: 27 VPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQ-LV 85
Query: 497 ALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKS-NL 555
L + +I EIP I K L+ +GN + + EL+ L L + +L
Sbjct: 86 ELDVSRNEIPEIPESISFCKALQVADFSGNPLTR-----LPESFPELQNLTCLSVNDISL 140
Query: 556 SKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHN 615
LP+ + ++ +L L + E + +SL ++ L EL+L ++ +P SI +L +
Sbjct: 141 QSLPENIGNL-YNLASLELR-ENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLH 198
Query: 616 LQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIE 675
L+++ L N L + + I +L L CL + N + +P +I LT+L L +++N +E
Sbjct: 199 LKDLWLDGNQLSELPQEIG--NLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLE 256
Query: 676 KIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRA 735
IP + +KL L + N LT LP +G ++L L +T N++ TLP + + +KL
Sbjct: 257 TIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSN 316
Query: 736 LHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGE 775
L+ N L SLP +G +LT +R NRL +P E+ +
Sbjct: 317 LNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQ 356
Score = 116 bits (290), Expect = 1e-25
Identities = 87/268 (32%), Positives = 135/268 (50%), Gaps = 7/268 (2%)
Query: 534 YIVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMAN 592
Y+ + R + L+ L L +N L +LP+ + V L+KL +++ + + +
Sbjct: 26 YVPEEIYRYARSLEELLLDANQLRELPEQFFQL-VKLRKLGLSDNEIQRLP-PEIANFMQ 83
Query: 593 LTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIA 652
L EL++ R ++ IP SI LQ D N L + E SF L LTCL + +
Sbjct: 84 LVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPE--SFPELQNLTCLSVNDISLQ 141
Query: 653 YIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQN 712
+P IGNL NL L L N + +P L R+L LDL +N + LP IG L +L++
Sbjct: 142 SLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKD 201
Query: 713 LAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVE 772
L + N++ LP E+ + L L + N L+ LP + LT+LT + + N LE +P
Sbjct: 202 LWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDG 261
Query: 773 LGECPLLKRSGLVVEEDLFNTLPPEVKE 800
+G+ L K S L V+++ LP V E
Sbjct: 262 IGK--LKKLSILKVDQNRLTQLPEAVGE 287
Score = 110 bits (274), Expect = 7e-24
Identities = 105/350 (30%), Positives = 165/350 (47%), Gaps = 13/350 (3%)
Query: 426 DKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEA 485
++L L L +P+ F LV+L L L +PP IA L EL ++ E
Sbjct: 39 EELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVEL----DVSRNEI 94
Query: 486 PALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKR 545
P + +AL + D PL E +LT + + + + + L
Sbjct: 95 PEIPESISFCKALQV--ADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYN 152
Query: 546 LKVLRLKSNL-SKLPQVVTDVGVHLQKLSI-NNEGTKLIVLNSLKKMANLTELELIRCDL 603
L L L+ NL + LP +T + L++L + NNE L S+ + +L +L L L
Sbjct: 153 LASLELRENLLTYLPDSLTQLR-RLEELDLGNNEIYNLP--ESIGALLHLKDLWLDGNQL 209
Query: 604 ERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTN 663
+P I +L NL +D+ +N L+ + E IS L LT L + N + IP IG L
Sbjct: 210 SELPQEIGNLKNLLCLDVSENRLERLPEEIS--GLTSLTDLVISQNLLETIPDGIGKLKK 267
Query: 664 LERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETL 723
L L +++N++ ++P + C L L L+ N L LP IG L+ L NL N++ +L
Sbjct: 268 LSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSL 327
Query: 724 PPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVEL 773
P E+ C L + +N L +P+ V + T L +++ GNRL LP+ L
Sbjct: 328 PKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSL 377
Score = 71.2 bits (173), Expect = 4e-12
Identities = 75/290 (25%), Positives = 139/290 (47%), Gaps = 12/290 (4%)
Query: 435 LSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLREN 494
L+ +P++ +L L L + I ++P +I L L L L +L LR
Sbjct: 117 LTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRR- 175
Query: 495 LRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN 554
L L + +I +P I +L L++L L GN +E + I LK L L + N
Sbjct: 176 LEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEI-----GNLKNLLCLDVSEN 230
Query: 555 -LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSL 613
L +LP+ ++ + L L I+ + I + + K+ L+ L++ + L ++P ++
Sbjct: 231 RLERLPEEISGL-TSLTDLVISQNLLETIP-DGIGKLKKLSILKVDQNRLTQLPEAVGEC 288
Query: 614 HNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNK 673
+L E+ L +N L T+ + I L +L+ L N + +P +IG +L + N+
Sbjct: 289 ESLTELVLTENQLLTLPKSIG--KLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNR 346
Query: 674 IEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETL 723
+ +IP ++ +L LD++ N L LP + L+ L+ L ++ N+ + L
Sbjct: 347 LTRIPAEVSQATELHVLDVAGNRLLHLPLSLTALK-LKALWLSDNQSQPL 395
>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
Length = 1537
Score = 118 bits (295), Expect = 3e-26
Identities = 103/361 (28%), Positives = 166/361 (45%), Gaps = 37/361 (10%)
Query: 476 LYHTAAKIEA-PALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRY 534
LY A +IE P F + LR L I D+ +P I SL L+EL ++ N E
Sbjct: 51 LYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQE---- 106
Query: 535 IVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANL 593
+ ++ K L ++ N +SKLP T + ++L +L +N+ + + N ++ L
Sbjct: 107 -FPENIKCCKCLTIIEASVNPISKLPDGFTQL-LNLTQLYLNDAFLEFLPAN-FGRLVKL 163
Query: 594 TELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEII-------------------- 633
LEL L+ +P S+ L L+ +DL +N + E++
Sbjct: 164 RILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLP 223
Query: 634 -SFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDL 692
S L L L + N I + + I LE L L+ N ++++P + +KL L +
Sbjct: 224 GSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKV 283
Query: 693 SHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGE 752
N LT LP IG L L+ + N +E+LP + LR L + N L LP +G
Sbjct: 284 DDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGS 343
Query: 753 LTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLP---PEVKE--RLWRADK 807
N+T + LR N+LE LP E+G+ + K L + ++ LP ++KE LW +D
Sbjct: 344 CKNVTVMSLRSNKLEFLPEEIGQ--MQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDN 401
Query: 808 E 808
+
Sbjct: 402 Q 402
Score = 116 bits (290), Expect = 1e-25
Identities = 88/289 (30%), Positives = 149/289 (51%), Gaps = 9/289 (3%)
Query: 493 ENLRALHIKFTDIKEIPLWIYSL-KTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRL 551
E + L ++++P +++ +TLEEL+L N E + + + L++L +
Sbjct: 22 EIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLF--NCQALRKLSIP-- 77
Query: 552 KSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIF 611
++LS LP + + V+L++L I+ G + N +K LT +E + ++P
Sbjct: 78 DNDLSNLPTTIASL-VNLKELDISKNGVQEFPEN-IKCCKCLTIIEASVNPISKLPDGFT 135
Query: 612 SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNR 671
L NL ++ L D L+ + +F L +L L+L NH+ +P + L LERL L
Sbjct: 136 QLLNLTQLYLNDAFLEFLPA--NFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGN 193
Query: 672 NKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCR 731
N+ ++P L + LR L + +N L LP IG L+ L L ++ NRIET+ ++ C
Sbjct: 194 NEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCE 253
Query: 732 KLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK 780
L L L +N+LQ LP +G L LT +++ N+L LP +G LL+
Sbjct: 254 ALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLE 302
Score = 111 bits (277), Expect = 3e-24
Identities = 99/394 (25%), Positives = 177/394 (44%), Gaps = 55/394 (13%)
Query: 399 ENKLRQLNLNNEWTLDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDLVELE--------- 449
E L +L L+ + +Q A KL + LS +P T+ LV L+
Sbjct: 45 ERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGV 104
Query: 450 --------------VLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENL 495
+++ + P +P QL L +L+L + PA L
Sbjct: 105 QEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEF-LPANFGRLVKL 163
Query: 496 RALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNL 555
R L ++ +K +P ++ L LE L L N
Sbjct: 164 RILELRENHLKTLPKSMHKLAQLERLDLGNN---------------------------EF 196
Query: 556 SKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHN 615
+LP+V+ + +L++L ++N +++ S+ K+ L L++ + +E + I
Sbjct: 197 GELPEVLDQIQ-NLRELWMDNNALQVLP-GSIGKLKMLVYLDMSKNRIETVDMDISGCEA 254
Query: 616 LQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIE 675
L+++ L N L+ + + I L +LT LK+ N + +P IGNL+ LE + N++E
Sbjct: 255 LEDLLLSSNMLQQLPDSIGL--LKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELE 312
Query: 676 KIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRA 735
+P+ + Y LR L + N L LP +IG +N+ +++ +N++E LP E+ Q +KLR
Sbjct: 313 SLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRV 372
Query: 736 LHLGNNVLQSLPSRVGELTNLTQIELRGNRLECL 769
L+L +N L++LP +L L + L N+ + L
Sbjct: 373 LNLSDNRLKNLPFSFTKLKELAALWLSDNQSKAL 406
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 115 bits (287), Expect = 2e-25
Identities = 101/349 (28%), Positives = 168/349 (48%), Gaps = 17/349 (4%)
Query: 426 DKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEA 485
++L L + +P +F+ L L L T+P SIA L L+EL + + E
Sbjct: 49 EELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQ-EF 107
Query: 486 PALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVI--DGLREL 543
P + L + I ++P L L +L+L N+ ++ L
Sbjct: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYL-------NDAFLEFLPANFGRL 160
Query: 544 KRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSI-NNEGTKLIVLNSLKKMANLTELELIRC 601
+L++L L+ N L LP+ + + L++L + +NE T+ V L++++ L E +
Sbjct: 161 TKLQILELRENQLKMLPKTMNRL-TQLERLDLGSNEFTE--VPEVLEQLSGLKEFWMDAN 217
Query: 602 DLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNL 661
L IP I SL L +D+ NN++ +EE IS L L L N + +P IG+L
Sbjct: 218 RLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGIST--CENLQDLLLSSNSLQQLPETIGSL 275
Query: 662 TNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIE 721
N+ L ++ N++ +P + + LD S N + LP+ IG L NL+ A N ++
Sbjct: 276 KNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQ 335
Query: 722 TLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLP 770
LPPE+ + + L L +N L++LP +G++ L I L NRL+ LP
Sbjct: 336 QLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLP 384
Score = 110 bits (276), Expect = 4e-24
Identities = 88/300 (29%), Positives = 147/300 (49%), Gaps = 19/300 (6%)
Query: 493 ENLRALHIKFTDIKEIPLWIYSL-KTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRL 551
E + L ++++P I++ KTLEEL+L N E + + + L L L
Sbjct: 22 ETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLF-----NCQSLHKLSL 76
Query: 552 KSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSI 610
N L+ LP + ++ ++L++L ++ G + N +K LT +E + ++P
Sbjct: 77 PDNDLTTLPASIANL-INLRELDVSKNGIQEFPEN-IKNCKVLTIVEASVNPISKLPDGF 134
Query: 611 FSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLN 670
L NL ++ L D L+ + +F L +L L+L N + +P + LT LERL L
Sbjct: 135 SQLLNLTQLYLNDAFLEFLPA--NFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLG 192
Query: 671 RNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQC 730
N+ ++P L L+ + N LTF+P IG L+ L L ++ N IE + + C
Sbjct: 193 SNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTC 252
Query: 731 RKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDL 790
L+ L L +N LQ LP +G L N+T +++ N+L LP +G GL+ E+L
Sbjct: 253 ENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIG--------GLISVEEL 304
Score = 110 bits (276), Expect = 4e-24
Identities = 96/333 (28%), Positives = 156/333 (46%), Gaps = 40/333 (12%)
Query: 476 LYHTAAKIEA-PALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRY 534
LY A +IE P F ++L L + D+ +P I +L L EL ++ N E
Sbjct: 51 LYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQE---- 106
Query: 535 IVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANL 593
+ ++ K L ++ N +SKLP + + ++L +L +N+ + + N ++ L
Sbjct: 107 -FPENIKNCKVLTIVEASVNPISKLPDGFSQL-LNLTQLYLNDAFLEFLPAN-FGRLTKL 163
Query: 594 TELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWY---NH 650
LEL L+ +P ++ L L+ +DL N + E+ L +L+ LK ++ N
Sbjct: 164 QILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEV-----LEQLSGLKEFWMDANR 218
Query: 651 IAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNL 710
+ +IP IG+L L L +++N IE + + C L+ L LS N+L LP IG L+N+
Sbjct: 219 LTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNI 278
Query: 711 QNLAITANR-----------------------IETLPPELFQCRKLRALHLGNNVLQSLP 747
L I N+ +E LP + Q LR +N LQ LP
Sbjct: 279 TTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLP 338
Query: 748 SRVGELTNLTQIELRGNRLECLPVELGECPLLK 780
+G N+T + L N+LE LP E+G+ LK
Sbjct: 339 PEIGSWKNITVLFLHSNKLETLPEEMGDMQKLK 371
Score = 90.1 bits (222), Expect = 7e-18
Identities = 83/329 (25%), Positives = 148/329 (44%), Gaps = 36/329 (10%)
Query: 439 PDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRAL 498
P+ + + L +++ + P +P +QL L +L+L + PA L+ L
Sbjct: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEF-LPANFGRLTKLQIL 166
Query: 499 HIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN-LSK 557
++ +K +P + L LE L L N E V + L +L LK + +N L+
Sbjct: 167 ELRENQLKMLPKTMNRLTQLERLDLGSNEFTE-----VPEVLEQLSGLKEFWMDANRLTF 221
Query: 558 LPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQ 617
+P + + L L ++ +++ + NL +L L L+++P +I SL N+
Sbjct: 222 IPGFIGSLK-QLTYLDVSKNNIEMVE-EGISTCENLQDLLLSSNSLQQLPETIGSLKNIT 279
Query: 618 EIDLKDNNLKTIEEIIS-FQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEK 676
+ + +N L + + I + L C +N + +P IG LTN
Sbjct: 280 TLKIDENQLMYLPDSIGGLISVEELDCS---FNEVEALPSSIGQLTN------------- 323
Query: 677 IPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRAL 736
LR HN L LP +IG +N+ L + +N++ETLP E+ +KL+ +
Sbjct: 324 ----------LRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVI 373
Query: 737 HLGNNVLQSLPSRVGELTNLTQIELRGNR 765
+L +N L++LP +L LT + L N+
Sbjct: 374 NLSDNRLKNLPFSFTKLQQLTAMWLSDNQ 402
Score = 89.4 bits (220), Expect = 1e-17
Identities = 94/327 (28%), Positives = 149/327 (45%), Gaps = 61/327 (18%)
Query: 402 LRQLNLNNEWT--LDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDV 459
L QL LN+ + L RLTK LEL L +P T+ L +LE L L
Sbjct: 140 LTQLYLNDAFLEFLPANFGRLTK--LQILELRENQLKMLPKTMNRLTQLERLDLGSNEFT 197
Query: 460 TIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLE 519
+P + QL+GLKE W+ +A L F IP +I SLK L
Sbjct: 198 EVPEVLEQLSGLKEFWM-------DANRLTF-----------------IPGFIGSLKQLT 233
Query: 520 ELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEG 578
L ++ +NN +V +G+ + L+ L L SN L +LP+ +
Sbjct: 234 YLDVS-----KNNIEMVEEGISTCENLQDLLLSSNSLQQLPETI---------------- 272
Query: 579 TKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHL 638
SLK N+T L++ L +P SI L +++E+D N ++ + I L
Sbjct: 273 ------GSLK---NITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIG--QL 321
Query: 639 HRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT 698
L +N++ +P +IG+ N+ L+L+ NK+E +P ++ +KL+ ++LS N L
Sbjct: 322 TNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLK 381
Query: 699 FLPADIGLLQNLQNLAITANRIETLPP 725
LP LQ L + ++ N+ + L P
Sbjct: 382 NLPFSFTKLQQLTAMWLSDNQSKPLIP 408
Score = 88.6 bits (218), Expect = 2e-17
Identities = 58/157 (36%), Positives = 80/157 (50%), Gaps = 5/157 (3%)
Query: 642 TCLKLWYNH--IAYIPIQIGNLTN-LERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT 698
T L Y+H + +P +I LE LYL+ N+IE++P QLF C+ L L L N+LT
Sbjct: 23 TVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLT 82
Query: 699 FLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQ 758
LPA I L NL+ L ++ N I+ P + C+ L + N + LP +L NLTQ
Sbjct: 83 TLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQ 142
Query: 759 IELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLP 795
+ L LE LP G L K L + E+ LP
Sbjct: 143 LYLNDAFLEFLPANFGR--LTKLQILELRENQLKMLP 177
>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
Length = 1371
Score = 115 bits (287), Expect = 2e-25
Identities = 101/349 (28%), Positives = 168/349 (48%), Gaps = 17/349 (4%)
Query: 426 DKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEA 485
++L L + +P +F+ L L L T+P SIA L L+EL + + E
Sbjct: 49 EELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQ-EF 107
Query: 486 PALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVI--DGLREL 543
P + L + I ++P L L +L+L N+ ++ L
Sbjct: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYL-------NDAFLEFLPANFGRL 160
Query: 544 KRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSI-NNEGTKLIVLNSLKKMANLTELELIRC 601
+L++L L+ N L LP+ + + L++L + +NE T+ V L++++ L E +
Sbjct: 161 TKLQILELRENQLKMLPKTMNRL-TQLERLDLGSNEFTE--VPEVLEQLSGLKEFWMDAN 217
Query: 602 DLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNL 661
L IP I SL L +D+ NN++ +EE IS L L L N + +P IG+L
Sbjct: 218 RLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGIST--CENLQDLLLSSNSLQQLPETIGSL 275
Query: 662 TNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIE 721
N+ L ++ N++ +P + + LD S N + LP+ IG L NL+ A N ++
Sbjct: 276 KNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQ 335
Query: 722 TLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLP 770
LPPE+ + + L L +N L++LP +G++ L I L NRL+ LP
Sbjct: 336 QLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLP 384
Score = 110 bits (276), Expect = 4e-24
Identities = 88/300 (29%), Positives = 147/300 (49%), Gaps = 19/300 (6%)
Query: 493 ENLRALHIKFTDIKEIPLWIYSL-KTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRL 551
E + L ++++P I++ KTLEEL+L N E + + + L L L
Sbjct: 22 ETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLF-----NCQSLHKLSL 76
Query: 552 KSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSI 610
N L+ LP + ++ ++L++L ++ G + N +K LT +E + ++P
Sbjct: 77 PDNDLTTLPASIANL-INLRELDVSKNGIQEFPEN-IKNCKVLTIVEASVNPISKLPDGF 134
Query: 611 FSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLN 670
L NL ++ L D L+ + +F L +L L+L N + +P + LT LERL L
Sbjct: 135 SQLLNLTQLYLNDAFLEFLPA--NFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLG 192
Query: 671 RNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQC 730
N+ ++P L L+ + N LTF+P IG L+ L L ++ N IE + + C
Sbjct: 193 SNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTC 252
Query: 731 RKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDL 790
L+ L L +N LQ LP +G L N+T +++ N+L LP +G GL+ E+L
Sbjct: 253 ENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIG--------GLISVEEL 304
Score = 110 bits (276), Expect = 4e-24
Identities = 96/333 (28%), Positives = 156/333 (46%), Gaps = 40/333 (12%)
Query: 476 LYHTAAKIEA-PALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRY 534
LY A +IE P F ++L L + D+ +P I +L L EL ++ N E
Sbjct: 51 LYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQE---- 106
Query: 535 IVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANL 593
+ ++ K L ++ N +SKLP + + ++L +L +N+ + + N ++ L
Sbjct: 107 -FPENIKNCKVLTIVEASVNPISKLPDGFSQL-LNLTQLYLNDAFLEFLPAN-FGRLTKL 163
Query: 594 TELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWY---NH 650
LEL L+ +P ++ L L+ +DL N + E+ L +L+ LK ++ N
Sbjct: 164 QILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEV-----LEQLSGLKEFWMDANR 218
Query: 651 IAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNL 710
+ +IP IG+L L L +++N IE + + C L+ L LS N+L LP IG L+N+
Sbjct: 219 LTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNI 278
Query: 711 QNLAITANR-----------------------IETLPPELFQCRKLRALHLGNNVLQSLP 747
L I N+ +E LP + Q LR +N LQ LP
Sbjct: 279 TTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLP 338
Query: 748 SRVGELTNLTQIELRGNRLECLPVELGECPLLK 780
+G N+T + L N+LE LP E+G+ LK
Sbjct: 339 PEIGSWKNITVLFLHSNKLETLPEEMGDMQKLK 371
Score = 90.1 bits (222), Expect = 7e-18
Identities = 83/329 (25%), Positives = 148/329 (44%), Gaps = 36/329 (10%)
Query: 439 PDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRAL 498
P+ + + L +++ + P +P +QL L +L+L + PA L+ L
Sbjct: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEF-LPANFGRLTKLQIL 166
Query: 499 HIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN-LSK 557
++ +K +P + L LE L L N E V + L +L LK + +N L+
Sbjct: 167 ELRENQLKMLPKTMNRLTQLERLDLGSNEFTE-----VPEVLEQLSGLKEFWMDANRLTF 221
Query: 558 LPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQ 617
+P + + L L ++ +++ + NL +L L L+++P +I SL N+
Sbjct: 222 IPGFIGSLK-QLTYLDVSKNNIEMVE-EGISTCENLQDLLLSSNSLQQLPETIGSLKNIT 279
Query: 618 EIDLKDNNLKTIEEIIS-FQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEK 676
+ + +N L + + I + L C +N + +P IG LTN
Sbjct: 280 TLKIDENQLMYLPDSIGGLISVEELDCS---FNEVEALPSSIGQLTN------------- 323
Query: 677 IPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRAL 736
LR HN L LP +IG +N+ L + +N++ETLP E+ +KL+ +
Sbjct: 324 ----------LRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVI 373
Query: 737 HLGNNVLQSLPSRVGELTNLTQIELRGNR 765
+L +N L++LP +L LT + L N+
Sbjct: 374 NLSDNRLKNLPFSFTKLQQLTAMWLSDNQ 402
Score = 89.4 bits (220), Expect = 1e-17
Identities = 94/327 (28%), Positives = 149/327 (45%), Gaps = 61/327 (18%)
Query: 402 LRQLNLNNEWT--LDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDV 459
L QL LN+ + L RLTK LEL L +P T+ L +LE L L
Sbjct: 140 LTQLYLNDAFLEFLPANFGRLTK--LQILELRENQLKMLPKTMNRLTQLERLDLGSNEFT 197
Query: 460 TIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLE 519
+P + QL+GLKE W+ +A L F IP +I SLK L
Sbjct: 198 EVPEVLEQLSGLKEFWM-------DANRLTF-----------------IPGFIGSLKQLT 233
Query: 520 ELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEG 578
L ++ +NN +V +G+ + L+ L L SN L +LP+ +
Sbjct: 234 YLDVS-----KNNIEMVEEGISTCENLQDLLLSSNSLQQLPETI---------------- 272
Query: 579 TKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHL 638
SLK N+T L++ L +P SI L +++E+D N ++ + I L
Sbjct: 273 ------GSLK---NITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIG--QL 321
Query: 639 HRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT 698
L +N++ +P +IG+ N+ L+L+ NK+E +P ++ +KL+ ++LS N L
Sbjct: 322 TNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLK 381
Query: 699 FLPADIGLLQNLQNLAITANRIETLPP 725
LP LQ L + ++ N+ + L P
Sbjct: 382 NLPFSFTKLQQLTAMWLSDNQSKPLIP 408
Score = 88.6 bits (218), Expect = 2e-17
Identities = 58/157 (36%), Positives = 80/157 (50%), Gaps = 5/157 (3%)
Query: 642 TCLKLWYNH--IAYIPIQIGNLTN-LERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT 698
T L Y+H + +P +I LE LYL+ N+IE++P QLF C+ L L L N+LT
Sbjct: 23 TVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLT 82
Query: 699 FLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQ 758
LPA I L NL+ L ++ N I+ P + C+ L + N + LP +L NLTQ
Sbjct: 83 TLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQ 142
Query: 759 IELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLP 795
+ L LE LP G L K L + E+ LP
Sbjct: 143 LYLNDAFLEFLPANFGR--LTKLQILELRENQLKMLP 177
>gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens]
Length = 277
Score = 109 bits (272), Expect = 1e-23
Identities = 67/186 (36%), Positives = 100/186 (53%), Gaps = 4/186 (2%)
Query: 615 NLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKI 674
N E+D+ D + + ++ L +T L L +N + +P I L NLE L N+I
Sbjct: 16 NQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQI 75
Query: 675 EKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRI--ETLPPELFQCRK 732
E++PTQ+ +KL++L+L N L LP G L L+ L +T N + +LP F
Sbjct: 76 EELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTT 135
Query: 733 LRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFN 792
LRAL+L +N + LP +G+LT L + LR N L LP E+GE LK L ++ +
Sbjct: 136 LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKE--LHIQGNRLT 193
Query: 793 TLPPEV 798
LPPE+
Sbjct: 194 VLPPEL 199
Score = 97.1 bits (240), Expect = 6e-20
Identities = 74/238 (31%), Positives = 117/238 (49%), Gaps = 39/238 (16%)
Query: 544 KRLKVLRLKSNLSKLPQV-VTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCD 602
K LK L +S P+V ++D G+ + ++ +N L ++++T+L L
Sbjct: 3 KSLKKLVEESREKNQPEVDMSDRGI-----------SNMLDVNGLFTLSHITQLVLSHNK 51
Query: 603 LERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLT 662
L +P +I L NL E+++F + N I +P QI +L
Sbjct: 52 LTMVPPNIAELKNL--------------EVLNF-----------FNNQIEELPTQISSLQ 86
Query: 663 NLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT--FLPADIGLLQNLQNLAITANRI 720
L+ L L N++ +P L LDL++NNL+ LP + L L+ L ++ N
Sbjct: 87 KLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDF 146
Query: 721 ETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPL 778
E LPP++ + KL+ L L +N L SLP +GELT L ++ ++GNRL LP ELG L
Sbjct: 147 EILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDL 204
Score = 59.7 bits (143), Expect = 1e-08
Identities = 54/187 (28%), Positives = 81/187 (43%), Gaps = 26/187 (13%)
Query: 522 HLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTK 580
H+T + + N +V + ELK L+VL +N + +LP ++ LQKL N G
Sbjct: 41 HITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISS----LQKLKHLNLGMN 96
Query: 581 LIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHR 640
L +P SL L+ +DL NNL +F +L
Sbjct: 97 R---------------------LNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTT 135
Query: 641 LTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFL 700
L L L N +P IG LT L+ L L N + +P ++ +L+ L + N LT L
Sbjct: 136 LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVL 195
Query: 701 PADIGLL 707
P ++G L
Sbjct: 196 PPELGNL 202
Score = 40.0 bits (92), Expect = 0.009
Identities = 51/191 (26%), Positives = 82/191 (42%), Gaps = 9/191 (4%)
Query: 344 LRRSLKKYSFESIREESSYSDIPD--VKN----DFAFMLHLIDQYDPLYSKRFAVFLSEV 397
+ +SLKK ES + D+ D + N + F L I Q ++K V +
Sbjct: 1 MSKSLKKLVEESREKNQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIA 60
Query: 398 SENKLRQLNLNNEWTLDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLEL-- 455
L LN N + Q + L L + L+ +P L LEVL L
Sbjct: 61 ELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNN 120
Query: 456 IPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSL 515
+ + ++P + LT L+ L+L +I P + L + L+ L ++ D+ +P I L
Sbjct: 121 LSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTK-LQILSLRDNDLISLPKEIGEL 179
Query: 516 KTLEELHLTGN 526
L+ELH+ GN
Sbjct: 180 TQLKELHIQGN 190
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 103 bits (257), Expect = 6e-22
Identities = 129/511 (25%), Positives = 212/511 (41%), Gaps = 38/511 (7%)
Query: 285 YVHNIKFDVDCTVDIESLT----GYRTYRCAHPLATLFKILASFYISLVIFYGLICMYT- 339
Y+ N D++C ++E L+ R P ++L Y L F +C
Sbjct: 245 YIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPK 304
Query: 340 -----LWWMLRRSLKKYSFESIREESSYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFL 394
L L SL K IRE + + N F+ I Q + + A
Sbjct: 305 LISLDLTGNLISSLPK----EIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNK 360
Query: 395 SEVSENKLRQLNLNNEWTLDKLRQRLTKNAQDKLELHLFM---------LSGIPDTVFDL 445
EV +K+ LDK L KN +K+ + L+ +P + L
Sbjct: 361 LEVISHKIENFRELRILILDK---NLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKL 417
Query: 446 VELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDI 505
L L + V I I+ L + L + P + + + + + I
Sbjct: 418 NNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIIT-DVPIEIKNCQKIIKIELSYNKI 476
Query: 506 KEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDV 565
PL + +L +L L + GN +E I +D + K+L L L N +
Sbjct: 477 MYFPLGLCALDSLYYLSVNGNYISE----IPVD-ISFSKQLLHLELSENKLLIFSEHFCS 531
Query: 566 GVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNN 625
++L+ L + K I S+ M +L L L E P + +L NLQ +DL +N
Sbjct: 532 LINLKYLDLGKNQIKKIPA-SISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQ 590
Query: 626 LKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNR---NKIEKIPTQLF 682
L+ I I +L + L N + PI++ L +LE+L +++ K+ ++P +L
Sbjct: 591 LQKISSDIC--NLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELS 648
Query: 683 YCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNV 742
+L+ LD+S+N + +P +IG L+NL +L N+I LPP L L+ L+L N
Sbjct: 649 NMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNN 708
Query: 743 LQSLPSRVGELTNLTQIELRGNRLECLPVEL 773
L +LPS + + +L +I N L PVE+
Sbjct: 709 LTALPSAIYNIFSLKEINFDDNPLLRPPVEI 739
Score = 100 bits (249), Expect = 5e-21
Identities = 112/397 (28%), Positives = 175/397 (44%), Gaps = 37/397 (9%)
Query: 428 LELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPA 487
L+L ++S +P + +L LE L ++ + I QL +KEL L ++ +
Sbjct: 308 LDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHK 367
Query: 488 LAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLK 547
+ RE LR L + +K IP I LE L L+ N E +YI L L++L
Sbjct: 368 IENFRE-LRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYI--HKLNNLRKLH 424
Query: 548 VLRLKSNLSKLPQVVTDVGVHLQKL-SINNEGTKLI-VLNSLKKMANLTELELIRCDLER 605
V R +N+ K +TD HL + S+ G + V +K + ++EL +
Sbjct: 425 VNR--NNMVK----ITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMY 478
Query: 606 IPHSIFSLHNLQEIDLKDNNLKTIEEIISF--QHLH-------------------RLTCL 644
P + +L +L + + N + I ISF Q LH L L
Sbjct: 479 FPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYL 538
Query: 645 KLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADI 704
L N I IP I N+ +L L L NK E P +L L+ LDLS N L + +DI
Sbjct: 539 DLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDI 598
Query: 705 GLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQ---IEL 761
L+ +Q L ++N+ P EL Q + L L++ + L GEL+N+TQ +++
Sbjct: 599 CNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDI 658
Query: 762 RGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEV 798
N + +P +GE L L + + LPP +
Sbjct: 659 SNNAIREIPRNIGE--LRNLVSLHAYNNQISYLPPSL 693
Score = 92.0 bits (227), Expect = 2e-18
Identities = 100/396 (25%), Positives = 163/396 (41%), Gaps = 72/396 (18%)
Query: 468 LTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTL--------- 518
L GL+ L L P+ L NLR L++ I IP I L +
Sbjct: 187 LLGLEILSLQENGLS-SLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNY 245
Query: 519 -----EELHLTGNLS----AENNRYIVIDGLRELKRLKVLRLKSN--------------- 554
+L GNL +N + D L LK L+VL L+ N
Sbjct: 246 IENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKL 305
Query: 555 ---------LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLER 605
+S LP+ + ++ L +N+ T L V + ++ + EL+L LE
Sbjct: 306 ISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAV--EIFQLLKIKELQLADNKLEV 363
Query: 606 IPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLE 665
I H I + L+ + L N LK I E IS + L CL L N + +P I L NL
Sbjct: 364 ISHKIENFRELRILILDKNLLKNIPEKISCCAM--LECLSLSDNKLTELPKYIHKLNNLR 421
Query: 666 RLYLNRNKIEKI-----------------------PTQLFYCRKLRYLDLSHNNLTFLPA 702
+L++NRN + KI P ++ C+K+ ++LS+N + + P
Sbjct: 422 KLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPL 481
Query: 703 DIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELR 762
+ L +L L++ N I +P ++ ++L L L N L L NL ++L
Sbjct: 482 GLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLG 541
Query: 763 GNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEV 798
N+++ +P + ++ L++ + F T P E+
Sbjct: 542 KNQIKKIPASISN--MISLHVLILCCNKFETFPREL 575
Score = 89.0 bits (219), Expect = 2e-17
Identities = 59/187 (31%), Positives = 97/187 (51%), Gaps = 4/187 (2%)
Query: 613 LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRN 672
L L+ + L++N L ++ I Q LH L L + +NHI++IP +I L N+ +L+ N
Sbjct: 187 LLGLEILSLQENGLSSLPSEI--QLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNN 244
Query: 673 KIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRK 732
IE P+ L L L L N L +P + L+ L+ L + N++ T P L K
Sbjct: 245 YIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPK 304
Query: 733 LRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFN 792
L +L L N++ SLP + EL NL + + N+L L VE+ + LLK L + ++
Sbjct: 305 LISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQ--LLKIKELQLADNKLE 362
Query: 793 TLPPEVK 799
+ +++
Sbjct: 363 VISHKIE 369
Score = 84.7 bits (208), Expect = 3e-16
Identities = 72/261 (27%), Positives = 127/261 (48%), Gaps = 7/261 (2%)
Query: 522 HLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVG--VHLQKLSINNEGT 579
+ T NL A+ + D L+ +K +K L L N K Q D G + L+ LS+ G
Sbjct: 143 NFTVNLEAKGLQEFPKDILK-IKYVKYLYLDKNQIKTFQGA-DSGDLLGLEILSLQENGL 200
Query: 580 KLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLH 639
+ + ++ + NL L + + IP I L N++++ +N ++ + L
Sbjct: 201 SSLP-SEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPS--DLECLG 257
Query: 640 RLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTF 699
L L L N + +IP + +L L L L N++ P L + KL LDL+ N ++
Sbjct: 258 NLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISS 317
Query: 700 LPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQI 759
LP +I L+NL+ L + N++ L E+FQ K++ L L +N L+ + ++ L +
Sbjct: 318 LPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRIL 377
Query: 760 ELRGNRLECLPVELGECPLLK 780
L N L+ +P ++ C +L+
Sbjct: 378 ILDKNLLKNIPEKISCCAMLE 398
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 102 bits (255), Expect = 1e-21
Identities = 68/227 (29%), Positives = 120/227 (52%), Gaps = 5/227 (2%)
Query: 554 NLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSL 613
NLS++PQ V + V + + + N+ + +LT+L + L+ + + L
Sbjct: 47 NLSEVPQCVWRINVDIPEEA--NQNLSFGATERWWEQTDLTKLIISNNKLQSLTDDLRLL 104
Query: 614 HNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNK 673
L +D+ DN L ++ I + L L L + +N + +P +I NL NL+ LYL N+
Sbjct: 105 PALTVLDIHDNQLTSLPSAI--RELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNE 162
Query: 674 IEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKL 733
+ I L LDLS+N+LT +PA L +L L +++N +++LP E+ + ++L
Sbjct: 163 LTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRL 222
Query: 734 RALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK 780
+ L +N+L+++P + + +L + LR N+L LP E C LLK
Sbjct: 223 KHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLP-EFPSCSLLK 268
Score = 83.6 bits (205), Expect = 7e-16
Identities = 116/442 (26%), Positives = 199/442 (45%), Gaps = 66/442 (14%)
Query: 397 VSENKLRQL-----NLNNEWTLDKLRQRLT---------KNAQDKLELHLFMLSGIPDTV 442
VS NKL+ L NL N L LT N +D L+L L+ +P +
Sbjct: 135 VSHNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLED-LDLSNNHLTTVPASF 193
Query: 443 FDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKF 502
L L L L ++P I ++ LK L + P LA + E+L L+++
Sbjct: 194 SSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGM-ESLELLYLRR 252
Query: 503 TDIKEIPLWIYSLKTLEELHLTGN----LSAEN----NRYIVIDGLRE------------ 542
++ +P + S L+ELH+ N L AE+ N +V+D LR+
Sbjct: 253 NKLRFLPEFP-SCSLLKELHVGENQIEMLEAEHLKHLNSILVLD-LRDNKLKSVPDEIIL 310
Query: 543 LKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLI-----------VLNSLK-- 588
L+ L+ L L +N +S LP + ++ HL+ L++ + I VL L+
Sbjct: 311 LRSLERLDLSNNDISSLPYSLGNL--HLKFLALEGNPLRTIRREIISKGTQEVLKYLRSK 368
Query: 589 -------KMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTI-EEIISFQHLHR 640
+ + TE + R+ +I ++ L+ +D D I +E+ +
Sbjct: 369 IKDDGPSQSESATETAMTLPSESRV--NIHAIITLKILDYSDKQATLIPDEVFDAVKSNI 426
Query: 641 LTCLKLWYNHIAYIPIQIGNLTNL-ERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTF 699
+T + N + IP ++ L + + L+ NK+ I +L +KL +LDL +N L
Sbjct: 427 VTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNS 486
Query: 700 LPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSL-PSRVGELTNLTQ 758
LP ++ L LQ + ++ NR + LP L++ L + + NN + S+ P ++ + NLT
Sbjct: 487 LPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTT 546
Query: 759 IELRGNRLECLPVELGECPLLK 780
++L+ N L +P ELG C L+
Sbjct: 547 LDLQNNDLLQIPPELGNCVNLR 568
Score = 76.3 bits (186), Expect = 1e-13
Identities = 48/160 (30%), Positives = 78/160 (48%), Gaps = 25/160 (15%)
Query: 662 TNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIE 721
T+L +L ++ NK++ + L L LD+ N LT LP+ I L+NLQ L ++ N+++
Sbjct: 82 TDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLK 141
Query: 722 TLPPELFQCRKLRALH-----------------------LGNNVLQSLPSRVGELTNLTQ 758
LP E+ R L+ L+ L NN L ++P+ L++L +
Sbjct: 142 ILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVR 201
Query: 759 IELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEV 798
+ L N L+ LP E+ LK L +L T+PPE+
Sbjct: 202 LNLSSNELKSLPAEINRMKRLKH--LDCNSNLLETIPPEL 239
Score = 67.4 bits (163), Expect = 5e-11
Identities = 93/404 (23%), Positives = 164/404 (40%), Gaps = 64/404 (15%)
Query: 400 NKLRQLNLNNEWTLDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDV 459
+ L L+L+N + ++ +L L L +P + + L+ L
Sbjct: 174 SNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLE 233
Query: 460 TIPPSIAQLTGLKELWLYHTAAKI--EAPALAFLRE---------NLRALHIKFTD---- 504
TIPP +A + L+ L+L + E P+ + L+E L A H+K +
Sbjct: 234 TIPPELAGMESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSILV 293
Query: 505 -------IKEIPLWIYSLKTLEELHLTGN----------------LSAENN------RYI 535
+K +P I L++LE L L+ N L+ E N R I
Sbjct: 294 LDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLHLKFLALEGNPLRTIRREI 353
Query: 536 VIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGT--KLIVLNSLKKMANL 593
+ G +E+ + ++K + + T+ + L S N L +L+ K A L
Sbjct: 354 ISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQATL 413
Query: 594 --------------TELELIRCDLERIPHSIFSLHNL-QEIDLKDNNLKTIEEIISFQHL 638
T + + L IP + L + ++DL N L I + L
Sbjct: 414 IPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFIS--LELCVL 471
Query: 639 HRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT 698
+LT L L N + +P ++ +L L+ + L+ N+ + +P L+ L + +S+N +
Sbjct: 472 QKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVG 531
Query: 699 FL-PADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNN 741
+ P + +++NL L + N + +PPEL C LR L L N
Sbjct: 532 SVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGN 575
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 101 bits (252), Expect = 2e-21
Identities = 73/240 (30%), Positives = 121/240 (50%), Gaps = 7/240 (2%)
Query: 559 PQVVTDVGV-HLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSL-HNL 616
PQ+V + ++ L++ N G + + + +L L L R R+P ++ L H+L
Sbjct: 54 PQLVLPANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHL 113
Query: 617 QEIDLKDNNLKTI-EEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIE 675
E+D+ N L + E++S L L L L +N + +P Q+G L +LE L ++ N++
Sbjct: 114 TELDVSHNRLTALGAEVVSA--LRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLA 171
Query: 676 KIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRA 735
+P L +LR LD+ HN LT P + L L+ L +++NR+ LP ++ R L+
Sbjct: 172 HLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKI 231
Query: 736 LHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLP 795
L L L +LP+ EL +L + L N L+ LP + LK L + +LF P
Sbjct: 232 LWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKM--LNLSSNLFEEFP 289
Score = 99.0 bits (245), Expect = 2e-20
Identities = 90/343 (26%), Positives = 159/343 (46%), Gaps = 26/343 (7%)
Query: 449 EVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEI 508
+ L+ P + +P ++ + L L + + L +LR L ++ +
Sbjct: 46 DALESPASPQLVLPANLGDIEALN---LGNNGLEEVPEGLGSALGSLRVLVLRRNRFARL 102
Query: 509 PLWIYSLKTLEELHLTGNLSAENNRYI-----VIDGLRELKRLKVLRLKSNLSKLPQVVT 563
P + L HLT L +NR V+ LREL++L + ++LP +
Sbjct: 103 PPAVAELGH----HLT-ELDVSHNRLTALGAEVVSALRELRKLNLSH-----NQLPALPA 152
Query: 564 DVGV--HLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDL 621
+G HL++L ++ + +SL ++ L L++ L P + L L+E+D+
Sbjct: 153 QLGALAHLEELDVSFNRLAHLP-DSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDV 211
Query: 622 KDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQL 681
N L+ + E IS L L L L + +P L +LE L L+ N ++ +P Q
Sbjct: 212 SSNRLRGLPEDISA--LRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQF 269
Query: 682 FYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNN 741
++L+ L+LS N PA + L L+ L ++ N++ ++P + +L L L NN
Sbjct: 270 SCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNN 329
Query: 742 VLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGL 784
++ LP + ELT L ++ L+GN++ LP G+ L R GL
Sbjct: 330 RIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQ---LSRVGL 369
Score = 45.8 bits (107), Expect = 2e-04
Identities = 57/266 (21%), Positives = 114/266 (42%), Gaps = 31/266 (11%)
Query: 361 SYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQRL 420
S++ +P + + HL ++ D +++ + S ++LR L++++ RQ L
Sbjct: 143 SHNQLPALPAQLGALAHL-EELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLL 201
Query: 421 TKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTA 480
A ++L++ L G+P+ + L L++L L T+P +L L+ L L +
Sbjct: 202 QLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNG 261
Query: 481 AKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGL 540
+ PA + L+ L++ +E P + L LEEL+L+ N
Sbjct: 262 LQ-ALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRN-------------- 306
Query: 541 RELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIR 600
L+ +P +++ +G L L ++N + + +S+ ++ L EL L
Sbjct: 307 -------------QLTSVPSLISGLG-RLLTLWLDNNRIRYLP-DSIVELTGLEELVLQG 351
Query: 601 CDLERIPHSIFSLHNLQEIDLKDNNL 626
+ +P L + +KDN L
Sbjct: 352 NQIAVLPDHFGQLSRVGLWKIKDNPL 377
>gi|4503743 flightless I homolog [Homo sapiens]
Length = 1269
Score = 101 bits (251), Expect = 3e-21
Identities = 98/343 (28%), Positives = 156/343 (45%), Gaps = 13/343 (3%)
Query: 428 LELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEA-P 486
L+L+ L +P+ + L +LE L + T+ ++ L L+ + + K P
Sbjct: 38 LKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVP 97
Query: 487 ALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRL 546
F ++L L + + E P + + K + L+L+ N + I+ L L
Sbjct: 98 DDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFIN----LTDL 153
Query: 547 KVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELEL--IRCDL 603
L L N L LP + + VHLQ L +N L L M L L L +
Sbjct: 154 LYLDLSENRLESLPPQMRRL-VHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQ 212
Query: 604 ERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTN 663
+P S+ L NL ++DL N+L + E + L L L L N I + + I +
Sbjct: 213 SNLPTSLEGLSNLADVDLSCNDLTRVPECL--YTLPSLRRLNLSSNQITELSLCIDQWVH 270
Query: 664 LERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTF--LPADIGLLQNLQNLAITANRIE 721
+E L L+RN++ +P+ + KL+ L L+ N L F LP+ IG L NL+ N +E
Sbjct: 271 VETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLE 330
Query: 722 TLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGN 764
+P L +C KLR L L N L +LP + LT + +++R N
Sbjct: 331 LVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVREN 373
Score = 85.1 bits (209), Expect = 2e-16
Identities = 92/339 (27%), Positives = 161/339 (47%), Gaps = 47/339 (13%)
Query: 494 NLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDG-LRELKRLKVLRLK 552
+LR L + T + +P + +L+ LE +LS +N + G L L L+ + +
Sbjct: 34 SLRWLKLNRTGLCYLPEELAALQKLE------HLSVSHNNLTTLHGELSSLPSLRAIVAR 87
Query: 553 SNLSKLPQVVTDVGVHLQKLSI----NNEGTKLIVLNSLKKMANLTELELIRCDLERIPH 608
+N K V D+ L LS+ +N+ T+ L+ N+ L L ++ IP+
Sbjct: 88 ANSLKNSGVPDDI-FKLDDLSVLDLSHNQLTECP--RELENAKNMLVLNLSHNSIDTIPN 144
Query: 609 SIF-SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPI-QIGNLTNLER 666
+F +L +L +DL +N L+++ + L L L L N + + + Q+ +T L+
Sbjct: 145 QLFINLTDLLYLDLSENRLESLPP--QMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQT 202
Query: 667 LYLNRNKIEK--IPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRI---- 720
L+L + + +PT L L +DLS N+LT +P + L +L+ L +++N+I
Sbjct: 203 LHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELS 262
Query: 721 -------------------ETLPPELFQCRKLRALHLGNNVL--QSLPSRVGELTNLTQI 759
+LP + + KL+ L+L +N L LPS +G+LTNL +
Sbjct: 263 LCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEF 322
Query: 760 ELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEV 798
N LE +P L CP L++ LV+ ++ TLP +
Sbjct: 323 MAANNNLELVPESLCRCPKLRK--LVLNKNHLVTLPEAI 359
Score = 84.0 bits (206), Expect = 5e-16
Identities = 84/323 (26%), Positives = 146/323 (45%), Gaps = 44/323 (13%)
Query: 436 SGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENL 495
SG+PD +F L +L VL L S QLT E P +N+
Sbjct: 94 SGVPDDIFKLDDLSVLDL----------SHNQLT--------------ECPRELENAKNM 129
Query: 496 RALHIKFTDIKEIPLWIY-SLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN 554
L++ I IP ++ +L L L L+ EN + +R L L+ L L N
Sbjct: 130 LVLNLSHNSIDTIPNQLFINLTDLLYLDLS-----ENRLESLPPQMRRLVHLQTLVLNGN 184
Query: 555 ------LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPH 608
L +LP + +HL+ + + T+ + SL+ ++NL +++L DL R+P
Sbjct: 185 PLLHAQLRQLPAMTALQTLHLR----STQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPE 240
Query: 609 SIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLY 668
+++L +L+ ++L N + + I Q +H T L L N + +P I L+ L++LY
Sbjct: 241 CLYTLPSLRRLNLSSNQITELSLCID-QWVHVET-LNLSRNQLTSLPSAICKLSKLKKLY 298
Query: 669 LNRNKIE--KIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPE 726
LN NK++ +P+ + L ++NNL +P + L+ L + N + TLP
Sbjct: 299 LNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEA 358
Query: 727 LFQCRKLRALHLGNNVLQSLPSR 749
+ ++ L + N +P +
Sbjct: 359 IHFLTEIEVLDVRENPNLVMPPK 381
Score = 68.6 bits (166), Expect = 2e-11
Identities = 43/149 (28%), Positives = 77/149 (51%), Gaps = 3/149 (2%)
Query: 653 YIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQN 712
Y P + +T+L L LNR + +P +L +KL +L +SHNNLT L ++ L +L+
Sbjct: 24 YFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRA 83
Query: 713 LAITANRIET--LPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLP 770
+ AN ++ +P ++F+ L L L +N L P + N+ + L N ++ +P
Sbjct: 84 IVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIP 143
Query: 771 VELGECPLLKRSGLVVEEDLFNTLPPEVK 799
+L L L + E+ +LPP+++
Sbjct: 144 NQL-FINLTDLLYLDLSENRLESLPPQMR 171
>gi|33285015 leucine rich repeat containing 28 [Homo sapiens]
Length = 367
Score = 100 bits (250), Expect = 4e-21
Identities = 60/162 (37%), Positives = 96/162 (59%), Gaps = 1/162 (0%)
Query: 613 LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRN 672
L L+ + +K N+L ++ E ++ Q L L L L N+I +P IG+L L+ L L+ N
Sbjct: 40 LQYLERLYMKRNSLTSLPENLA-QKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDN 98
Query: 673 KIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRK 732
+E + ++ R LR+L L++N L FLP ++G L+ LQ L I+ NR+ TLP L C
Sbjct: 99 ALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLS 158
Query: 733 LRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELG 774
L+ L + N L +P + +L +L ++ + GNRL LP++LG
Sbjct: 159 LQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLG 200
Score = 96.3 bits (238), Expect = 1e-19
Identities = 62/198 (31%), Positives = 112/198 (56%), Gaps = 5/198 (2%)
Query: 554 NLSKLP-QVVTDVGV-HLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIF 611
NL P +++ D G+ +L++L + + N +K+ NL EL L ++ +P +I
Sbjct: 26 NLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIG 85
Query: 612 SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNR 671
SL LQ +DL DN L+ + I L L L+L N + ++P ++G+L L+ L ++
Sbjct: 86 SLVKLQCLDLSDNALEIVCPEIG--RLRALRHLRLANNQLQFLPPEVGDLKELQTLDIST 143
Query: 672 NKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCR 731
N++ +P +L C L+YL + N L ++P + L +L L++ NR+ LP +L + R
Sbjct: 144 NRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSR 203
Query: 732 KLRALHLGNNV-LQSLPS 748
+L+ +++ NN+ L+ LPS
Sbjct: 204 ELQYVYVDNNIHLKGLPS 221
Score = 82.0 bits (201), Expect = 2e-15
Identities = 55/148 (37%), Positives = 77/148 (52%), Gaps = 4/148 (2%)
Query: 633 ISFQHLHRLTCLKLWYNHIAYIPIQI---GNLTNLERLYLNRNKIEKIPTQLFY-CRKLR 688
IS L + L L Y ++ + P+++ L LERLY+ RN + +P L L
Sbjct: 9 ISVARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLV 68
Query: 689 YLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPS 748
L L NN+ +P IG L LQ L ++ N +E + PE+ + R LR L L NN LQ LP
Sbjct: 69 ELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPP 128
Query: 749 RVGELTNLTQIELRGNRLECLPVELGEC 776
VG+L L +++ NRL LP L C
Sbjct: 129 EVGDLKELQTLDISTNRLLTLPERLHMC 156
Score = 73.2 bits (178), Expect = 9e-13
Identities = 56/180 (31%), Positives = 88/180 (48%), Gaps = 4/180 (2%)
Query: 593 LTELELIRCDLERIPHSIFS-LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHI 651
L L + R L +P ++ L NL E+ L NN+ + E I L +L CL L N +
Sbjct: 43 LERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIG--SLVKLQCLDLSDNAL 100
Query: 652 AYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQ 711
+ +IG L L L L N+++ +P ++ ++L+ LD+S N L LP + + +LQ
Sbjct: 101 EIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQ 160
Query: 712 NLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGN-RLECLP 770
L + NR+ +P L Q L L + N L LP +G L + + N L+ LP
Sbjct: 161 YLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNNIHLKGLP 220
Score = 35.0 bits (79), Expect = 0.28
Identities = 43/169 (25%), Positives = 76/169 (44%), Gaps = 9/169 (5%)
Query: 412 TLDKLRQRLTKNAQDKLELHLFM--LSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLT 469
+L L + L + + +EL+L + +P+ + LV+L+ L L + P I +L
Sbjct: 52 SLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLR 111
Query: 470 GLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSA 529
L+ L L + + P + L+E L+ L I + +P ++ +L+ L + N
Sbjct: 112 ALRHLRLANNQLQFLPPEVGDLKE-LQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLW 170
Query: 530 ENNRYIV-IDGLREL----KRLKVLRLKSNLSK-LPQVVTDVGVHLQKL 572
R++ + L EL RL L L S+ L V D +HL+ L
Sbjct: 171 YVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNNIHLKGL 219
>gi|61742786 leucine rich repeat and death domain containing protein
isoform 3 [Homo sapiens]
Length = 893
Score = 100 bits (248), Expect = 7e-21
Identities = 63/185 (34%), Positives = 103/185 (55%), Gaps = 2/185 (1%)
Query: 599 IRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQI 658
+R L +P + L +L +DL N+L+T+ + + L L L +N ++ +P +
Sbjct: 110 LRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVL--QMRGLGALLLSHNCLSELPEAL 167
Query: 659 GNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITAN 718
G L L L + N+++ +P L L+ LDLS N L LP +IG L +L L + +N
Sbjct: 168 GALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASN 227
Query: 719 RIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPL 778
R+++LP L R LR L L +N+L S+P+ + L LT+++LR N+L LP EL + P
Sbjct: 228 RLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPF 287
Query: 779 LKRSG 783
++ G
Sbjct: 288 VRLQG 292
Score = 89.7 bits (221), Expect = 1e-17
Identities = 55/161 (34%), Positives = 85/161 (52%), Gaps = 2/161 (1%)
Query: 638 LHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNL 697
L L L L +N + +P + + L L L+ N + ++P L L +L ++HN L
Sbjct: 124 LAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRL 183
Query: 698 TFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLT 757
LP +G L LQ L ++ N ++TLPPE+ L L+L +N LQSLP+ + L +L
Sbjct: 184 QTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLR 243
Query: 758 QIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEV 798
+ L N L +P +L PLL R L + ++ LPPE+
Sbjct: 244 LLVLHSNLLASVPADLARLPLLTR--LDLRDNQLRDLPPEL 282
Score = 70.5 bits (171), Expect = 6e-12
Identities = 43/102 (42%), Positives = 61/102 (59%), Gaps = 2/102 (1%)
Query: 697 LTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNL 756
LT LPA + L +L +L ++ N +ETLP + Q R L AL L +N L LP +G L L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
Query: 757 TQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEV 798
T + + NRL+ LP LG L+R L + ++L +TLPPE+
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQR--LDLSQNLLDTLPPEI 213
Score = 37.7 bits (86), Expect = 0.043
Identities = 58/221 (26%), Positives = 90/221 (40%), Gaps = 33/221 (14%)
Query: 412 TLDKLRQRLTKNAQDKLELHLFM---LSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQL 468
+L LR + K Q + L + L+ +P + L L L L T+P + Q+
Sbjct: 88 SLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQM 147
Query: 469 TGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLS 528
GL L L H AL L L L + ++ +P + +L TL+ L L+ NL
Sbjct: 148 RGLGALLLSHNCLSELPEALGALPA-LTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 206
Query: 529 AENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLK 588
+ I GL L L + + L LP + + +L+VL+S
Sbjct: 207 --DTLPPEIGGLGSLLELNLA--SNRLQSLPASLAGL-----------RSLRLLVLHS-- 249
Query: 589 KMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTI 629
NL L + DL R+P L +DL+DN L+ +
Sbjct: 250 ---NL--LASVPADLARLPL-------LTRLDLRDNQLRDL 278
>gi|61742784 leucine rich repeat and death domain containing protein
isoform 1 [Homo sapiens]
Length = 910
Score = 100 bits (248), Expect = 7e-21
Identities = 63/185 (34%), Positives = 103/185 (55%), Gaps = 2/185 (1%)
Query: 599 IRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQI 658
+R L +P + L +L +DL N+L+T+ + + L L L +N ++ +P +
Sbjct: 110 LRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVL--QMRGLGALLLSHNCLSELPEAL 167
Query: 659 GNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITAN 718
G L L L + N+++ +P L L+ LDLS N L LP +IG L +L L + +N
Sbjct: 168 GALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASN 227
Query: 719 RIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPL 778
R+++LP L R LR L L +N+L S+P+ + L LT+++LR N+L LP EL + P
Sbjct: 228 RLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPF 287
Query: 779 LKRSG 783
++ G
Sbjct: 288 VRLQG 292
Score = 89.7 bits (221), Expect = 1e-17
Identities = 55/161 (34%), Positives = 85/161 (52%), Gaps = 2/161 (1%)
Query: 638 LHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNL 697
L L L L +N + +P + + L L L+ N + ++P L L +L ++HN L
Sbjct: 124 LAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRL 183
Query: 698 TFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLT 757
LP +G L LQ L ++ N ++TLPPE+ L L+L +N LQSLP+ + L +L
Sbjct: 184 QTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLR 243
Query: 758 QIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEV 798
+ L N L +P +L PLL R L + ++ LPPE+
Sbjct: 244 LLVLHSNLLASVPADLARLPLLTR--LDLRDNQLRDLPPEL 282
Score = 70.5 bits (171), Expect = 6e-12
Identities = 43/102 (42%), Positives = 61/102 (59%), Gaps = 2/102 (1%)
Query: 697 LTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNL 756
LT LPA + L +L +L ++ N +ETLP + Q R L AL L +N L LP +G L L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
Query: 757 TQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEV 798
T + + NRL+ LP LG L+R L + ++L +TLPPE+
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQR--LDLSQNLLDTLPPEI 213
Score = 37.7 bits (86), Expect = 0.043
Identities = 58/221 (26%), Positives = 90/221 (40%), Gaps = 33/221 (14%)
Query: 412 TLDKLRQRLTKNAQDKLELHLFM---LSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQL 468
+L LR + K Q + L + L+ +P + L L L L T+P + Q+
Sbjct: 88 SLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQM 147
Query: 469 TGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLS 528
GL L L H AL L L L + ++ +P + +L TL+ L L+ NL
Sbjct: 148 RGLGALLLSHNCLSELPEALGALPA-LTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 206
Query: 529 AENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLK 588
+ I GL L L + + L LP + + +L+VL+S
Sbjct: 207 --DTLPPEIGGLGSLLELNLA--SNRLQSLPASLAGL-----------RSLRLLVLHS-- 249
Query: 589 KMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTI 629
NL L + DL R+P L +DL+DN L+ +
Sbjct: 250 ---NL--LASVPADLARLPL-------LTRLDLRDNQLRDL 278
>gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens]
Length = 224
Score = 94.0 bits (232), Expect = 5e-19
Identities = 58/147 (39%), Positives = 82/147 (55%), Gaps = 4/147 (2%)
Query: 654 IPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNL 713
+P I L NLE L N+IE++PTQ+ +KL++L+L N L LP G L L+ L
Sbjct: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
Query: 714 AITANRI--ETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPV 771
+T N + +LP F LRAL+L +N + LP +G+LT L + LR N L LP
Sbjct: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
Query: 772 ELGECPLLKRSGLVVEEDLFNTLPPEV 798
E+GE LK L ++ + LPPE+
Sbjct: 122 EIGELTQLKE--LHIQGNRLTVLPPEL 146
Score = 92.8 bits (229), Expect = 1e-18
Identities = 55/143 (38%), Positives = 79/143 (55%), Gaps = 2/143 (1%)
Query: 638 LHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNL 697
L L L + N I +P QI +L L+ L L N++ +P L LDL++NNL
Sbjct: 9 LKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNL 68
Query: 698 T--FLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTN 755
+ LP + L L+ L ++ N E LPP++ + KL+ L L +N L SLP +GELT
Sbjct: 69 SENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQ 128
Query: 756 LTQIELRGNRLECLPVELGECPL 778
L ++ ++GNRL LP ELG L
Sbjct: 129 LKELHIQGNRLTVLPPELGNLDL 151
Score = 55.1 bits (131), Expect = 3e-07
Identities = 51/174 (29%), Positives = 75/174 (43%), Gaps = 26/174 (14%)
Query: 535 IVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANL 593
+V + ELK L+VL +N + +LP ++ LQKL N G
Sbjct: 1 MVPPNIAELKNLEVLNFFNNQIEELPTQISS----LQKLKHLNLGMNR------------ 44
Query: 594 TELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAY 653
L +P SL L+ +DL NNL +F +L L L L N
Sbjct: 45 ---------LNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEI 95
Query: 654 IPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLL 707
+P IG LT L+ L L N + +P ++ +L+ L + N LT LP ++G L
Sbjct: 96 LPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 149
Score = 41.2 bits (95), Expect = 0.004
Identities = 50/176 (28%), Positives = 76/176 (43%), Gaps = 30/176 (17%)
Query: 486 PALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKR 545
P +A L+ NL L+ I+E+P I SL+ L+ L+L N + G L
Sbjct: 4 PNIAELK-NLEVLNFFNNQIEELPTQISSLQKLKHLNL-----GMNRLNTLPRGFGSLPA 57
Query: 546 LKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLER 605
L+VL L N LS N+ L +L+ L L D E
Sbjct: 58 LEVLDLTYN----------------NLSENSLPGNFFYLTTLR------ALYLSDNDFEI 95
Query: 606 IPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNL 661
+P I L LQ + L+DN+L ++ + I L +L L + N + +P ++GNL
Sbjct: 96 LPPDIGKLTKLQILSLRDNDLISLPKEIG--ELTQLKELHIQGNRLTVLPPELGNL 149
Score = 38.1 bits (87), Expect = 0.033
Identities = 31/101 (30%), Positives = 51/101 (50%), Gaps = 3/101 (2%)
Query: 428 LELHLFMLSGIPDTVFDLVELEVLKLEL--IPDVTIPPSIAQLTGLKELWLYHTAAKIEA 485
L L + L+ +P L LEVL L + + ++P + LT L+ L+L +I
Sbjct: 38 LNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILP 97
Query: 486 PALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGN 526
P + L + L+ L ++ D+ +P I L L+ELH+ GN
Sbjct: 98 PDIGKLTK-LQILSLRDNDLISLPKEIGELTQLKELHIQGN 137
>gi|21389431 leucine rich repeat containing 39 [Homo sapiens]
Length = 335
Score = 93.2 bits (230), Expect = 9e-19
Identities = 76/238 (31%), Positives = 121/238 (50%), Gaps = 5/238 (2%)
Query: 544 KRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDL 603
K +++ + +L+KL + VT + L I E K + +SL K+ L E +L R L
Sbjct: 38 KLVRIWEERVSLTKLREKVTREDGRVI-LKIEKEEWKTLP-SSLLKLNQLQEWQLHRTGL 95
Query: 604 ERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTN 663
+IP I NL +DL N + I I L RL L L YN I +P ++ N +
Sbjct: 96 LKIPEFIGRFQNLIVLDLSRNTISEIPPGIGL--LTRLQELILSYNKIKTVPKELSNCAS 153
Query: 664 LERLYLNRNK-IEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIET 722
LE+L L N+ I +P +L KL +LDLS N+ T +P + + L+ L + +N++E
Sbjct: 154 LEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQ 213
Query: 723 LPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK 780
LP + + + L L L N + LP + + NL + L N+L+ +PV + E L+
Sbjct: 214 LPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLR 271
Score = 87.4 bits (215), Expect = 5e-17
Identities = 71/218 (32%), Positives = 103/218 (47%), Gaps = 12/218 (5%)
Query: 551 LKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSI 610
L S+L KL Q LQ+ ++ G L + + + NL L+L R + IP I
Sbjct: 75 LPSSLLKLNQ--------LQEWQLHRTGL-LKIPEFIGRFQNLIVLDLSRNTISEIPPGI 125
Query: 611 FSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNH-IAYIPIQIGNLTNLERLYL 669
L LQE+ L N +KT+ + +S + L L+L N I +P ++ NL L L L
Sbjct: 126 GLLTRLQELILSYNKIKTVPKELS--NCASLEKLELAVNRDICDLPQELSNLLKLTHLDL 183
Query: 670 NRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQ 729
+ N IP + L +LD+ N L LP I +QNL L + N I LP +
Sbjct: 184 SMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISN 243
Query: 730 CRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLE 767
+ L L L NN LQ +P + E+ NL + R N L+
Sbjct: 244 MKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLK 281
Score = 72.4 bits (176), Expect = 2e-12
Identities = 67/248 (27%), Positives = 110/248 (44%), Gaps = 31/248 (12%)
Query: 450 VLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIP 509
+LK+E T+P S+ +L L+E W H ++ P +NL L + I EIP
Sbjct: 64 ILKIEKEEWKTLPSSLLKLNQLQE-WQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIP 122
Query: 510 LWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHL 569
I L L+EL L+ N K V + SN + L ++
Sbjct: 123 PGIGLLTRLQELILSYN-----------------KIKTVPKELSNCASLEKL-------- 157
Query: 570 QKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTI 629
+L++N + L L + LT L+L D IP ++ ++ L+ +D+ N L+ +
Sbjct: 158 -ELAVNRDICDL--PQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQL 214
Query: 630 EEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRY 689
+ I + + L L L N I +P I N+ NL L L+ NK++ IP + LR+
Sbjct: 215 PDTI--ERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRF 272
Query: 690 LDLSHNNL 697
++ N L
Sbjct: 273 VNFRDNPL 280
>gi|4758460 glycoprotein V (platelet) [Homo sapiens]
Length = 560
Score = 92.0 bits (227), Expect = 2e-18
Identities = 99/353 (28%), Positives = 171/353 (48%), Gaps = 42/353 (11%)
Query: 439 PDTVFDLVELEVLKLELIPDVTIPPSIA-QLTGLKELWLYHTAAKIEAPALAFLRENLRA 497
P T DL++L+ L+L +P ++ ++ L++L+L H A + + NL+
Sbjct: 91 PGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQE 150
Query: 498 LHIKFTDIKEIPLWIYS-LKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLS 556
L + + +P +++ L+ L+ L L+GN NL+
Sbjct: 151 LALNQNQLDFLPASLFTNLENLKLLDLSGN---------------------------NLT 183
Query: 557 KLPQVVTDVGVHLQKLSINNEGTKLIVLNS--LKKMANLTELELIRCDLERIPHSIFS-L 613
LP+ + L++L +++ +L+ L+S L + LTEL+ R + I F L
Sbjct: 184 HLPKGLLGAQAKLERLLLHSN--RLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRL 241
Query: 614 HNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIP-IQIGNLTNLERLYLNRN 672
NL + L N+L + + F H H LT L L+ N +A +P + G + L+ L+LNR
Sbjct: 242 PNLSSLTLSRNHLAFLPSAL-FLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRT 300
Query: 673 KIEKIPTQLF-YCRKLRYLDLSHN-NLTFLP-ADIGLLQNLQNLAITANRIETLPPELFQ 729
++ +P F +LRYL ++ + L+ LP L LQ LA+ +N + LP L +
Sbjct: 301 QLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLR 360
Query: 730 -CRKLRALHLGNNVLQSLPSRV-GELTNLTQIELRGNRLECLPVEL-GECPLL 779
KLR + L N L++LP + L++L ++L N+LE LP ++ G P L
Sbjct: 361 GLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRL 413
Score = 60.5 bits (145), Expect = 6e-09
Identities = 58/210 (27%), Positives = 94/210 (44%), Gaps = 29/210 (13%)
Query: 569 LQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFS-LHNLQEIDLKDNNLK 627
LQ+L I++ + + + L L L R + +P ++ + L+++ L N L+
Sbjct: 76 LQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALR 135
Query: 628 TIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLF-YCRK 686
I++ + FQ L NL+ L LN+N+++ +P LF
Sbjct: 136 GIDQNM-FQ-----------------------KLVNLQELALNQNQLDFLPASLFTNLEN 171
Query: 687 LRYLDLSHNNLTFLPAD-IGLLQNLQNLAITANRIETLPPELF-QCRKLRALHLGNNVLQ 744
L+ LDLS NNLT LP +G L+ L + +NR+ +L L L L N ++
Sbjct: 172 LKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIR 231
Query: 745 SL-PSRVGELTNLTQIELRGNRLECLPVEL 773
S+ P L NL+ + L N L LP L
Sbjct: 232 SIAPGAFDRLPNLSSLTLSRNHLAFLPSAL 261
>gi|157743290 leucine rich repeat containing 30 [Homo sapiens]
Length = 301
Score = 91.7 bits (226), Expect = 3e-18
Identities = 60/212 (28%), Positives = 105/212 (49%), Gaps = 4/212 (1%)
Query: 587 LKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKL 646
LK+ + L+ + IP ++ L +Q+++L N L+ + + L R+ L L
Sbjct: 44 LKRGMHHVSFSLVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVG--KLTRIVVLNL 101
Query: 647 WYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGL 706
N + +P ++ L L+ L++N N + ++P +L CRKL L LSHN L+ LPA
Sbjct: 102 CGNRLKSLPREVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFAD 161
Query: 707 LQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRL 766
L L+ L ++ N +P +F ++L LH+G+N L+++ + L +L GN +
Sbjct: 162 LSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNI 221
Query: 767 ECLPVELGECPLLKRSGLVVEEDLFNTLPPEV 798
P L C + L + + TLP E+
Sbjct: 222 HSFPRSL--CLVTSLELLNLNNNDIQTLPSEL 251
Score = 58.9 bits (141), Expect = 2e-08
Identities = 70/273 (25%), Positives = 109/273 (39%), Gaps = 64/273 (23%)
Query: 435 LSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLREN 494
++ IPD ++ L E++ L L +PP + +LT + L L K P L +
Sbjct: 60 MTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLK-SLPREVSLLQC 118
Query: 495 LRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN 554
L+ L + + E+P + + LE L L+ N
Sbjct: 119 LKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNC--------------------------- 151
Query: 555 LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLH 614
LS+LP D+ L+KL+++N IP +FSL
Sbjct: 152 LSQLPACFADLS-RLRKLNLSNN------------------------FFAHIPMCVFSLK 186
Query: 615 NLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKI 674
L + + N L+ I E S QHL L N+I P + +T+LE L LN N I
Sbjct: 187 ELIFLHVGSNRLENIAE--SIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDI 244
Query: 675 EKIPTQL-FYCRKLRY--------LDLSHNNLT 698
+ +P++L CR +R L +SHN L+
Sbjct: 245 QTLPSELHLLCRLVRIAWNPMDKGLHISHNPLS 277
>gi|193788651 leucine rich repeat containing 69 [Homo sapiens]
Length = 347
Score = 89.7 bits (221), Expect = 1e-17
Identities = 75/248 (30%), Positives = 115/248 (46%), Gaps = 17/248 (6%)
Query: 519 EELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEG 578
E L + +N + I ++G K+ ++ S L KLP + T V LQ NN
Sbjct: 3 ERLLIKALSGGKNTKIITLNGK------KMTKMPSALGKLPGLKTLV---LQ----NNLI 49
Query: 579 TKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHL 638
K V L + LT L L LE +P + L +L+ + L N + + L
Sbjct: 50 PK--VCPELCNLTQLTTLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPG-ACDGL 106
Query: 639 HRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT 698
L L L NH+ +P ++ L +L + +N N++ IP +L + L L L++N L
Sbjct: 107 QNLILLNLNNNHLTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLI 166
Query: 699 FLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQ 758
+P +I L+ LQ L + N I LP EL +KLR L + N++Q PS +L L +
Sbjct: 167 CIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDL-KLRE 225
Query: 759 IELRGNRL 766
GN L
Sbjct: 226 FYCEGNPL 233
Score = 76.6 bits (187), Expect = 8e-14
Identities = 57/212 (26%), Positives = 102/212 (48%), Gaps = 12/212 (5%)
Query: 569 LQKLSINNEGTKLIVLNSLK---------KMANLTELELIRCDLERIPHSIFSLHNLQEI 619
L K + TK+I LN K K+ L L L + ++ + +L L +
Sbjct: 6 LIKALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTL 65
Query: 620 DLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIA-YIPIQIGNLTNLERLYLNRNKIEKIP 678
+L +N L+ + E ++L L L L N I + P L NL L LN N + ++P
Sbjct: 66 NLGNNLLEEVPE--EMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLP 123
Query: 679 TQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHL 738
++ + L Y+ +++N L +P ++ L+NL L + N++ +P E+ +KL+ L L
Sbjct: 124 QEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLL 183
Query: 739 GNNVLQSLPSRVGELTNLTQIELRGNRLECLP 770
N + LP + +L L +++ GN ++ P
Sbjct: 184 ARNNIGVLPEELCDLKKLRILDIAGNIIQIFP 215
Score = 72.4 bits (176), Expect = 2e-12
Identities = 51/159 (32%), Positives = 80/159 (50%), Gaps = 3/159 (1%)
Query: 641 LTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT-F 699
L L L N I + ++ NLT L L L N +E++P ++ Y L+ L LS N + F
Sbjct: 39 LKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRF 98
Query: 700 LPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQI 759
P LQNL L + N + LP E+ + + L + + N L S+P + L NL ++
Sbjct: 99 APGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVEL 158
Query: 760 ELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEV 798
+L N+L C+P E+ L K L++ + LP E+
Sbjct: 159 QLNYNQLICIPEEIKF--LKKLQKLLLARNNIGVLPEEL 195
Score = 58.9 bits (141), Expect = 2e-08
Identities = 66/245 (26%), Positives = 104/245 (42%), Gaps = 60/245 (24%)
Query: 461 IPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEE 520
+P ++ +L GLK L L + P L L + L L++ ++E+P + L +L+
Sbjct: 29 MPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQ-LTTLNLGNNLLEEVPEEMKYLTSLKN 87
Query: 521 LHLTGNLSAENNRYI--VIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNE 577
LHL+GN R+ DG L+ L +L L +N L++LPQ V+
Sbjct: 88 LHLSGNRIC---RFAPGACDG---LQNLILLNLNNNHLTQLPQEVS-------------- 127
Query: 578 GTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQH 637
++ +LT + + L IP + L NL E+ L N L I E I F
Sbjct: 128 -----------RLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKF-- 174
Query: 638 LHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNL 697
L L++L L RN I +P +L +KLR LD++ N +
Sbjct: 175 -----------------------LKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNII 211
Query: 698 TFLPA 702
P+
Sbjct: 212 QIFPS 216
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.139 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,688,939
Number of Sequences: 37866
Number of extensions: 1331216
Number of successful extensions: 5796
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 113
Number of HSP's successfully gapped in prelim test: 156
Number of HSP's that attempted gapping in prelim test: 3884
Number of HSP's gapped (non-prelim): 859
length of query: 810
length of database: 18,247,518
effective HSP length: 110
effective length of query: 700
effective length of database: 14,082,258
effective search space: 9857580600
effective search space used: 9857580600
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.