Guide to the Human Genome
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Name: POLE Sequence: fasta or formatted (2286aa) NCBI GI: 62198237
Description:

DNA-directed DNA polymerase epsilon

Referenced in:

DNA Polymerases

Composition:

amino acid map
 Amino acid        Percentage    Count  Longest homopolymer
 A alanine             7.0        161           3
 C cysteine            2.1         47           1
 D aspartate           5.4        124           2
 E glutamate           8.3        190           5
 F phenylalanine       4.4        101           2
 G glycine             4.9        113           2
 H histidine           2.7         61           2
 I isoleucine          5.4        123           2
 K lysine              5.8        133           3
 L leucine             9.8        225           3
 M methionine          2.4         56           2
 N asparagine          3.4         77           2
 P proline             4.8        109           3
 Q glutamine           4.5        102           2
 R arginine            6.3        144           3
 S serine              6.9        158           3
 T threonine           4.2         96           2
 V valine              6.6        150           2
 W tryptophan          1.4         33           1
 Y tyrosine            3.6         83           2
Comparative genomics:

Search single species RefSeq proteins at NCBI
   H. sapiens
   M. musculus
   D. rerio
   C. intestinalis
   S. purpuratus
   D. melanogaster
   C. elegans
   A. thaliana
   S. cerevisiae
   E. coli W3110
   A. pernix K1

Search summary

comparative genomics plot

   Figure data

Additional searches of
RefSeq proteins at NCBI

   All
   Eukaryotes
   Bacteria
   Archaea
   Viruses
   Primates
   Mammals
   Vertebrates

Related human proteins:
Protein          Relative score         Description

Self-match            1.000   DNA-directed DNA polymerase epsilon 
POLA1                 0.005   DNA-directed DNA polymerase alpha 1 
CCDC136               0.004   coiled-coil domain containing 136 
ZBTB7C                0.004   zinc finger and BTB domain containing 7C 
PTMA                  0.003   prothymosin, alpha isoform 1 
PTMA                  0.003   prothymosin, alpha isoform 2 
TTBK1                 0.003   tau tubulin kinase 1 
MYST4                 0.003   MYST histone acetyltransferase (monocytic leukemia)...
MICAL3                0.003   microtubule associated monoxygenase, calponin and L...
SLC24A1               0.003   solute carrier family 24 (sodium/potassium/calcium ex...
SHROOM4               0.003   shroom family member 4 
RYR1                  0.003   skeletal muscle ryanodine receptor isoform 2 
RYR1                  0.003   skeletal muscle ryanodine receptor isoform 1 
MCTP2                 0.003   multiple C2 domains, transmembrane 2 isoform 1 [Hom...
ZFHX3                 0.003   AT-binding transcription factor 1 
MYT1                  0.003   myelin transcription factor 1 
CHIC1                 0.003   cysteine-rich hydrophobic domain 1 
ARID4B                0.003   AT rich interactive domain 4B isoform 2 
ARID4B                0.003   AT rich interactive domain 4B isoform 1 
DCAF8L2               0.003   DDB1 and CUL4 associated factor 8-like 2 
C14orf37              0.003   hypothetical protein LOC145407 
FAM123B               0.003   family with sequence similarity 123B 
DAXX                  0.003   death-domain associated protein isoform a 
DAXX                  0.003   death-domain associated protein isoform a 
DAXX                  0.003   death-domain associated protein isoform b 
SUPT5H                0.003   suppressor of Ty 5 homolog isoform b 
SUPT5H                0.003   suppressor of Ty 5 homolog isoform a 
SUPT5H                0.003   suppressor of Ty 5 homolog isoform a 
SUPT5H                0.003   suppressor of Ty 5 homolog isoform a 
RANGAP1               0.003   Ran GTPase activating protein 1 
Human BLASTP results (used to prepare the table)

Gene descriptions are from NCBI RefSeq. Search results were obtained with NCBI BLAST and RefSeq entries. When identical proteins are present, the self-match may not be listed first in BLASTP output. In such cases, the table above has been reordered to place it first.

See About the Figures for the scoring system used in the figure above right. The same scoring system was used in the table of BLASTP results.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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