Search of human proteins with 61742829

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|61742829 disrupted in schizophrenia 1 isoform S [Homo
sapiens]
         (678 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|61742829 disrupted in schizophrenia 1 isoform S [Homo sapiens]    1357   0.0  
gi|61742825 disrupted in schizophrenia 1 isoform Lv [Homo sapiens]   1318   0.0  
gi|61742823 disrupted in schizophrenia 1 isoform L [Homo sapiens]    1318   0.0  
gi|61742827 disrupted in schizophrenia 1 isoform Es [Homo sapiens]    720   0.0  
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]                56   1e-07
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]    50   7e-06
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]             50   9e-06
gi|21735548 centrosomal protein 2 [Homo sapiens]                       49   1e-05
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...    49   2e-05
gi|10440566 leucine zipper, putative tumor suppressor 1 [Homo sa...    49   2e-05
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...    49   2e-05
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    48   3e-05
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    48   3e-05
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...    48   3e-05
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...    48   3e-05
gi|63252898 tropomyosin 1 alpha chain isoform 1 [Homo sapiens]         48   3e-05
gi|156104874 envoplakin [Homo sapiens]                                 47   6e-05
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...    47   8e-05
gi|32698688 citron [Homo sapiens]                                      47   8e-05
gi|46592991 GRIP1 associated protein 1 isoform 1 [Homo sapiens]        46   1e-04
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ...    46   1e-04
gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapi...    46   1e-04
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]         46   1e-04
gi|223555975 tropomyosin 4 isoform 1 [Homo sapiens]                    45   2e-04
gi|205277396 dynactin 1 isoform 4 [Homo sapiens]                       45   2e-04
gi|205277392 dynactin 1 isoform 3 [Homo sapiens]                       45   2e-04
gi|13259508 dynactin 1 isoform 2 [Homo sapiens]                        45   2e-04
gi|13259510 dynactin 1 isoform 1 [Homo sapiens]                        45   2e-04
gi|31982906 cingulin-like 1 [Homo sapiens]                             45   2e-04
gi|63252896 tropomyosin 1 alpha chain isoform 3 [Homo sapiens]         45   3e-04

>gi|61742829 disrupted in schizophrenia 1 isoform S [Homo sapiens]
          Length = 678

 Score = 1357 bits (3512), Expect = 0.0
 Identities = 678/678 (100%), Positives = 678/678 (100%)

Query: 1   MPGGGPQGAPAAAGGGGVSHRAGSRDCLPPAACFRRRRLARRPGYMRSSTGPGIGFLSPA 60
           MPGGGPQGAPAAAGGGGVSHRAGSRDCLPPAACFRRRRLARRPGYMRSSTGPGIGFLSPA
Sbjct: 1   MPGGGPQGAPAAAGGGGVSHRAGSRDCLPPAACFRRRRLARRPGYMRSSTGPGIGFLSPA 60

Query: 61  VGTLFRFPGGVSGEESHHSESRARQCGLDSRGLLVRSPVSKSAAAPTVTSVRGTSAHFGI 120
           VGTLFRFPGGVSGEESHHSESRARQCGLDSRGLLVRSPVSKSAAAPTVTSVRGTSAHFGI
Sbjct: 61  VGTLFRFPGGVSGEESHHSESRARQCGLDSRGLLVRSPVSKSAAAPTVTSVRGTSAHFGI 120

Query: 121 QLRGGTRLPDRLSWPCGPGSAGWQQEFAAMDSSETLDASWEAACSDGARRVRAAGSLPSA 180
           QLRGGTRLPDRLSWPCGPGSAGWQQEFAAMDSSETLDASWEAACSDGARRVRAAGSLPSA
Sbjct: 121 QLRGGTRLPDRLSWPCGPGSAGWQQEFAAMDSSETLDASWEAACSDGARRVRAAGSLPSA 180

Query: 181 ELSSNSCSPGCGPEVPPTPPGSHSAFTSSFSFIRLSLGSAGERGEAEGCPPSREAESHCQ 240
           ELSSNSCSPGCGPEVPPTPPGSHSAFTSSFSFIRLSLGSAGERGEAEGCPPSREAESHCQ
Sbjct: 181 ELSSNSCSPGCGPEVPPTPPGSHSAFTSSFSFIRLSLGSAGERGEAEGCPPSREAESHCQ 240

Query: 241 SPQEMGAKAASLDGPHEDPRCLSRPFSLLATRVSADLAQAARNSSRPERDMHSLPDMDPG 300
           SPQEMGAKAASLDGPHEDPRCLSRPFSLLATRVSADLAQAARNSSRPERDMHSLPDMDPG
Sbjct: 241 SPQEMGAKAASLDGPHEDPRCLSRPFSLLATRVSADLAQAARNSSRPERDMHSLPDMDPG 300

Query: 301 SSSSLDPSLAGCGGDGSSGSGDAHSWDTLLRKWEPVLRDCLLRNRRQMEVISLRLKLQKL 360
           SSSSLDPSLAGCGGDGSSGSGDAHSWDTLLRKWEPVLRDCLLRNRRQMEVISLRLKLQKL
Sbjct: 301 SSSSLDPSLAGCGGDGSSGSGDAHSWDTLLRKWEPVLRDCLLRNRRQMEVISLRLKLQKL 360

Query: 361 QEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQVQAALRRGA 420
           QEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQVQAALRRGA
Sbjct: 361 QEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQVQAALRRGA 420

Query: 421 TQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLE 480
           TQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLE
Sbjct: 421 TQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLE 480

Query: 481 AKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPP 540
           AKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPP
Sbjct: 481 AKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPP 540

Query: 541 ETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNH 600
           ETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNH
Sbjct: 541 ETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNH 600

Query: 601 FWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAY 660
           FWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAY
Sbjct: 601 FWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAY 660

Query: 661 GYKYCDAESWTQRSQQLA 678
           GYKYCDAESWTQRSQQLA
Sbjct: 661 GYKYCDAESWTQRSQQLA 678


>gi|61742825 disrupted in schizophrenia 1 isoform Lv [Homo sapiens]
          Length = 832

 Score = 1318 bits (3411), Expect = 0.0
 Identities = 660/660 (100%), Positives = 660/660 (100%)

Query: 1   MPGGGPQGAPAAAGGGGVSHRAGSRDCLPPAACFRRRRLARRPGYMRSSTGPGIGFLSPA 60
           MPGGGPQGAPAAAGGGGVSHRAGSRDCLPPAACFRRRRLARRPGYMRSSTGPGIGFLSPA
Sbjct: 1   MPGGGPQGAPAAAGGGGVSHRAGSRDCLPPAACFRRRRLARRPGYMRSSTGPGIGFLSPA 60

Query: 61  VGTLFRFPGGVSGEESHHSESRARQCGLDSRGLLVRSPVSKSAAAPTVTSVRGTSAHFGI 120
           VGTLFRFPGGVSGEESHHSESRARQCGLDSRGLLVRSPVSKSAAAPTVTSVRGTSAHFGI
Sbjct: 61  VGTLFRFPGGVSGEESHHSESRARQCGLDSRGLLVRSPVSKSAAAPTVTSVRGTSAHFGI 120

Query: 121 QLRGGTRLPDRLSWPCGPGSAGWQQEFAAMDSSETLDASWEAACSDGARRVRAAGSLPSA 180
           QLRGGTRLPDRLSWPCGPGSAGWQQEFAAMDSSETLDASWEAACSDGARRVRAAGSLPSA
Sbjct: 121 QLRGGTRLPDRLSWPCGPGSAGWQQEFAAMDSSETLDASWEAACSDGARRVRAAGSLPSA 180

Query: 181 ELSSNSCSPGCGPEVPPTPPGSHSAFTSSFSFIRLSLGSAGERGEAEGCPPSREAESHCQ 240
           ELSSNSCSPGCGPEVPPTPPGSHSAFTSSFSFIRLSLGSAGERGEAEGCPPSREAESHCQ
Sbjct: 181 ELSSNSCSPGCGPEVPPTPPGSHSAFTSSFSFIRLSLGSAGERGEAEGCPPSREAESHCQ 240

Query: 241 SPQEMGAKAASLDGPHEDPRCLSRPFSLLATRVSADLAQAARNSSRPERDMHSLPDMDPG 300
           SPQEMGAKAASLDGPHEDPRCLSRPFSLLATRVSADLAQAARNSSRPERDMHSLPDMDPG
Sbjct: 241 SPQEMGAKAASLDGPHEDPRCLSRPFSLLATRVSADLAQAARNSSRPERDMHSLPDMDPG 300

Query: 301 SSSSLDPSLAGCGGDGSSGSGDAHSWDTLLRKWEPVLRDCLLRNRRQMEVISLRLKLQKL 360
           SSSSLDPSLAGCGGDGSSGSGDAHSWDTLLRKWEPVLRDCLLRNRRQMEVISLRLKLQKL
Sbjct: 301 SSSSLDPSLAGCGGDGSSGSGDAHSWDTLLRKWEPVLRDCLLRNRRQMEVISLRLKLQKL 360

Query: 361 QEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQVQAALRRGA 420
           QEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQVQAALRRGA
Sbjct: 361 QEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQVQAALRRGA 420

Query: 421 TQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLE 480
           TQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLE
Sbjct: 421 TQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLE 480

Query: 481 AKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPP 540
           AKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPP
Sbjct: 481 AKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPP 540

Query: 541 ETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNH 600
           ETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNH
Sbjct: 541 ETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNH 600

Query: 601 FWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAY 660
           FWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAY
Sbjct: 601 FWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAY 660


>gi|61742823 disrupted in schizophrenia 1 isoform L [Homo sapiens]
          Length = 854

 Score = 1318 bits (3411), Expect = 0.0
 Identities = 660/660 (100%), Positives = 660/660 (100%)

Query: 1   MPGGGPQGAPAAAGGGGVSHRAGSRDCLPPAACFRRRRLARRPGYMRSSTGPGIGFLSPA 60
           MPGGGPQGAPAAAGGGGVSHRAGSRDCLPPAACFRRRRLARRPGYMRSSTGPGIGFLSPA
Sbjct: 1   MPGGGPQGAPAAAGGGGVSHRAGSRDCLPPAACFRRRRLARRPGYMRSSTGPGIGFLSPA 60

Query: 61  VGTLFRFPGGVSGEESHHSESRARQCGLDSRGLLVRSPVSKSAAAPTVTSVRGTSAHFGI 120
           VGTLFRFPGGVSGEESHHSESRARQCGLDSRGLLVRSPVSKSAAAPTVTSVRGTSAHFGI
Sbjct: 61  VGTLFRFPGGVSGEESHHSESRARQCGLDSRGLLVRSPVSKSAAAPTVTSVRGTSAHFGI 120

Query: 121 QLRGGTRLPDRLSWPCGPGSAGWQQEFAAMDSSETLDASWEAACSDGARRVRAAGSLPSA 180
           QLRGGTRLPDRLSWPCGPGSAGWQQEFAAMDSSETLDASWEAACSDGARRVRAAGSLPSA
Sbjct: 121 QLRGGTRLPDRLSWPCGPGSAGWQQEFAAMDSSETLDASWEAACSDGARRVRAAGSLPSA 180

Query: 181 ELSSNSCSPGCGPEVPPTPPGSHSAFTSSFSFIRLSLGSAGERGEAEGCPPSREAESHCQ 240
           ELSSNSCSPGCGPEVPPTPPGSHSAFTSSFSFIRLSLGSAGERGEAEGCPPSREAESHCQ
Sbjct: 181 ELSSNSCSPGCGPEVPPTPPGSHSAFTSSFSFIRLSLGSAGERGEAEGCPPSREAESHCQ 240

Query: 241 SPQEMGAKAASLDGPHEDPRCLSRPFSLLATRVSADLAQAARNSSRPERDMHSLPDMDPG 300
           SPQEMGAKAASLDGPHEDPRCLSRPFSLLATRVSADLAQAARNSSRPERDMHSLPDMDPG
Sbjct: 241 SPQEMGAKAASLDGPHEDPRCLSRPFSLLATRVSADLAQAARNSSRPERDMHSLPDMDPG 300

Query: 301 SSSSLDPSLAGCGGDGSSGSGDAHSWDTLLRKWEPVLRDCLLRNRRQMEVISLRLKLQKL 360
           SSSSLDPSLAGCGGDGSSGSGDAHSWDTLLRKWEPVLRDCLLRNRRQMEVISLRLKLQKL
Sbjct: 301 SSSSLDPSLAGCGGDGSSGSGDAHSWDTLLRKWEPVLRDCLLRNRRQMEVISLRLKLQKL 360

Query: 361 QEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQVQAALRRGA 420
           QEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQVQAALRRGA
Sbjct: 361 QEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQVQAALRRGA 420

Query: 421 TQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLE 480
           TQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLE
Sbjct: 421 TQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLE 480

Query: 481 AKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPP 540
           AKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPP
Sbjct: 481 AKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPP 540

Query: 541 ETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNH 600
           ETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNH
Sbjct: 541 ETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNH 600

Query: 601 FWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAY 660
           FWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAY
Sbjct: 601 FWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAY 660


>gi|61742827 disrupted in schizophrenia 1 isoform Es [Homo sapiens]
          Length = 369

 Score =  720 bits (1859), Expect = 0.0
 Identities = 350/355 (98%), Positives = 352/355 (99%)

Query: 1   MPGGGPQGAPAAAGGGGVSHRAGSRDCLPPAACFRRRRLARRPGYMRSSTGPGIGFLSPA 60
           MPGGGPQGAPAAAGGGGVSHRAGSRDCLPPAACFRRRRLARRPGYMRSSTGPGIGFLSPA
Sbjct: 1   MPGGGPQGAPAAAGGGGVSHRAGSRDCLPPAACFRRRRLARRPGYMRSSTGPGIGFLSPA 60

Query: 61  VGTLFRFPGGVSGEESHHSESRARQCGLDSRGLLVRSPVSKSAAAPTVTSVRGTSAHFGI 120
           VGTLFRFPGGVSGEESHHSESRARQCGLDSRGLLVRSPVSKSAAAPTVTSVRGTSAHFGI
Sbjct: 61  VGTLFRFPGGVSGEESHHSESRARQCGLDSRGLLVRSPVSKSAAAPTVTSVRGTSAHFGI 120

Query: 121 QLRGGTRLPDRLSWPCGPGSAGWQQEFAAMDSSETLDASWEAACSDGARRVRAAGSLPSA 180
           QLRGGTRLPDRLSWPCGPGSAGWQQEFAAMDSSETLDASWEAACSDGARRVRAAGSLPSA
Sbjct: 121 QLRGGTRLPDRLSWPCGPGSAGWQQEFAAMDSSETLDASWEAACSDGARRVRAAGSLPSA 180

Query: 181 ELSSNSCSPGCGPEVPPTPPGSHSAFTSSFSFIRLSLGSAGERGEAEGCPPSREAESHCQ 240
           ELSSNSCSPGCGPEVPPTPPGSHSAFTSSFSFIRLSLGSAGERGEAEGCPPSREAESHCQ
Sbjct: 181 ELSSNSCSPGCGPEVPPTPPGSHSAFTSSFSFIRLSLGSAGERGEAEGCPPSREAESHCQ 240

Query: 241 SPQEMGAKAASLDGPHEDPRCLSRPFSLLATRVSADLAQAARNSSRPERDMHSLPDMDPG 300
           SPQEMGAKAASLDGPHEDPRCLSRPFSLLATRVSADLAQAARNSSRPERDMHSLPDMDPG
Sbjct: 241 SPQEMGAKAASLDGPHEDPRCLSRPFSLLATRVSADLAQAARNSSRPERDMHSLPDMDPG 300

Query: 301 SSSSLDPSLAGCGGDGSSGSGDAHSWDTLLRKWEPVLRDCLLRNRRQMEVISLRL 355
           SSSSLDPSLAGCGGDGSSGSGDAHSWDTLLRKWEPVLRDCLLRNRRQME+  + L
Sbjct: 301 SSSSLDPSLAGCGGDGSSGSGDAHSWDTLLRKWEPVLRDCLLRNRRQMELEPIAL 355


>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
          Length = 2017

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 138/623 (22%), Positives = 242/623 (38%), Gaps = 124/623 (19%)

Query: 145  QEFAAMDSSE------TLDASWEAACSDGARRVRAAGSLPSAELSSNSCSPGCGPEVPPT 198
            QE AA+++ +      TL    +A  SD    V+ +GS  +A+ +SN    G   +  P+
Sbjct: 436  QEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTAD-ASNGSLRGLSGQRTPS 494

Query: 199  PPGSHSAFTSSFSFIRLSLGSAGERGEAEGCPPS-----------------REAESHCQS 241
            PP   S             G +  RG +  C  S                 ++     ++
Sbjct: 495  PPRRSSP----------GRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEA 544

Query: 242  PQE-MGAKAASLDGPHEDPRCLSRPFSLLATRVSADLAQAARNSSRPERDMHSLPDMDPG 300
             Q+ +G     L     + R L      L  +    + QA  ++ R  + + S  ++   
Sbjct: 545  SQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAM-QAHEDAQREVQRLRSANELLSR 603

Query: 301  SSSSLDPSLAGCGGDGSSGSGDAHSWDTLLRKWEPVLRDCLLRNRRQMEVISLRLKLQKL 360
              S+L                 AHS     ++ E + ++       Q E+   R +L++ 
Sbjct: 604  EKSNL-----------------AHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEE 646

Query: 361  QEDAVENDD--YDKAETLQQRLEDLEQEKISLHFQLPSRQPALS------SFLGHLAAQV 412
            QEDAV++      + E   ++LE LE ++  L  +L   + ALS        L    A+V
Sbjct: 647  QEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEV 706

Query: 413  QAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEK-------QQL 465
              AL +    +   + + T LR E    E + QDSL       + L Q+K        QL
Sbjct: 707  AEALTKAEAGRVELELSMTKLRAE----EASLQDSLSKLSALNESLAQDKLDLNRLVAQL 762

Query: 466  QKEIEALQARMFVLE-----AKDQQLRREIEEQEQQLQWQGCDLTPLVGQLS-------L 513
            ++E  ALQ R    E     A+++Q R E    EQ++  QG + +  V + +       L
Sbjct: 763  EEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQL 822

Query: 514  GQLQEVSKALQDTLASAGQ--IPFHAEPPETIRSLQERIKSLNLSLKE----------IT 561
              L+     LQ+ LA   +       E  +  R  Q ++++L  + +E          + 
Sbjct: 823  PTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLA 882

Query: 562  TKVCMSEKFCSTLRKKVNDIETQLPAL-------------LEAKMHAI--SGNHFWTAKD 606
             ++  +E+   TL ++   +  +  AL             LEA+   +   G     AK+
Sbjct: 883  VQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKE 942

Query: 607  -LTEEIRSL------TSEREGLE-GLLSKLLVLSSRNV-----KKLGSVKEDYNRLRREV 653
             LT E+  L      T E+  L+  L+++ LV + R       ++  + +ED  RL+RE 
Sbjct: 943  TLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREK 1002

Query: 654  EHQETAYGYKYCDAESWTQRSQQ 676
            E        +    +S  QR Q+
Sbjct: 1003 EAAWRELEAERAQLQSQLQREQE 1025



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 76/316 (24%), Positives = 134/316 (42%), Gaps = 45/316 (14%)

Query: 343  RNRRQMEVISLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALS 402
            R  R +   + RL+L+K   +A+E   ++    +Q++L  LE  +  L  +  +   A  
Sbjct: 890  REGRTLSEEATRLRLEK---EALEGSLFE----VQRQLAQLEARREQLEAEGQALLLAKE 942

Query: 403  SFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLL--EPTAQDSLHVSITRRDWLLQ 460
            +  G LA   Q  +   ATQ+ +  D      M  +L+  E  AQ SL       +   +
Sbjct: 943  TLTGELAGLRQQII---ATQEKASLDKEL---MAQKLVQAEREAQASLREQRAAHE---E 993

Query: 461  EKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVS 520
            + Q+LQ+E EA       LEA+  QL+ +++ ++++L               L +L+   
Sbjct: 994  DLQRLQREKEAAWRE---LEAERAQLQSQLQREQEEL---------------LARLEAEK 1035

Query: 521  KALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVND 580
            + L + +A+  Q     E  E +  L E  K   LSLKE + K  +SEK   T R  +  
Sbjct: 1036 EELSEEIAALQQ-----ERDEGL-LLAESEKQQALSLKE-SEKTALSEKLMGT-RHSLAT 1087

Query: 581  IETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLG 640
            I  ++    +    +       T   LT E+R L ++RE      ++ +       + LG
Sbjct: 1088 ISLEMER-QKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLG 1146

Query: 641  SVKEDYNRLRREVEHQ 656
              ++   R   E+  Q
Sbjct: 1147 KQRDSCLREAEELRTQ 1162



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 86/387 (22%), Positives = 158/387 (40%), Gaps = 28/387 (7%)

Query: 268  LLATRVSADLAQAARNSSRPERDMHSLPDMDPGSSSSLDPSLAGCGGDGSSGSGDAHSWD 327
            L+ TR S  LA  +    R +RD  S  + D  + ++L   L          +  AH+ +
Sbjct: 1078 LMGTRHS--LATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAA-AHAQE 1134

Query: 328  TLLRKWEPVLRDC-LLRNRRQMEVISLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQE 386
              +R+ +   RD    R+    E   LR +L +L EDA +    +  E  ++  E  E  
Sbjct: 1135 --VRRLQEQARDLGKQRDSCLREAEELRTQL-RLLEDARDGLRRELLEAQRKLRESQEGR 1191

Query: 387  KISLHFQLPSRQPA--LSSFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTA 444
            ++        RQ A  L   LG   A+ + ALRR   +  S        R+  +L     
Sbjct: 1192 EVQ-------RQEAGELRRSLGE-GAKEREALRRSNEELRSAVKKAESERISLKLANEDK 1243

Query: 445  QDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDL 504
            +  L +    R  + +E  +L+  ++ ++        + Q+LRR+++  + +    G +L
Sbjct: 1244 EQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGREL 1303

Query: 505  TPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPPETIR-SLQERIKSLNLSLKEITTK 563
              L G+L+LG+  E  ++ ++TL    ++       E +R  LQ   + L     E  T+
Sbjct: 1304 AELQGRLALGERAE-KESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTR 1362

Query: 564  VCMSEKFCSTLRKKVNDIETQLPAL--LEAKMHAISGNHFWTAKDLTEEIRSLTSEREGL 621
                 +   +L +     + QL     LE K+ A        A +L   + +     +GL
Sbjct: 1363 ---ERRLLGSLEEARGTEKQQLDHARGLELKLEAARAE----AAELGLRLSAAEGRAQGL 1415

Query: 622  EGLLSKLLVLSSRNVKKLGSVKEDYNR 648
            E  L+++ V       +LG ++    R
Sbjct: 1416 EAELARVEVQRRAAEAQLGGLRSALRR 1442



 Score = 38.5 bits (88), Expect = 0.021
 Identities = 71/319 (22%), Positives = 129/319 (40%), Gaps = 36/319 (11%)

Query: 360  LQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQVQAALRRG 419
            LQE++V   + ++  TL Q +  LE+   +   +L + Q  +S    +   +++   RR 
Sbjct: 1583 LQEESVRRSERERRATLDQ-VATLERSLQATESELRASQEKISKMKAN-ETKLEGDKRRL 1640

Query: 420  ATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVL 479
                 + +     L ++ R LE   Q S  + ++ R+    + Q LQ  +++LQ ++   
Sbjct: 1641 KEVLDASESRTVKLELQRRSLEGELQRS-RLGLSDRE---AQAQALQDRVDSLQRQVADS 1696

Query: 480  EAKDQQLR----------REIEEQEQQLQWQGCDLTPLVGQ--LSLGQLQEVSKALQDTL 527
            E K   L+           ++EE E  L+ +   LT  + Q   SL   ++ +  LQ  L
Sbjct: 1697 EVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKAL 1756

Query: 528  ASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIET---- 583
             +              + LQER+ +   +L E   +     +   TLR +V D+E     
Sbjct: 1757 TAC---------EHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVE 1807

Query: 584  ---QLPALLEAKMHAISGN--HFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKK 638
               QL  L E       G      T + L +E R L      L+  L++L        + 
Sbjct: 1808 AEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERS 1867

Query: 639  LGSVKEDYNRLRREVEHQE 657
               +++D   LRR ++  E
Sbjct: 1868 ALRLEKDRVALRRTLDKVE 1886



 Score = 38.5 bits (88), Expect = 0.021
 Identities = 68/268 (25%), Positives = 120/268 (44%), Gaps = 45/268 (16%)

Query: 345  RRQMEVI------SLRLKLQK------LQEDAVENDDYD-KAETLQQRLEDLEQEKISLH 391
            RR  EV+      +++L+LQ+      LQ   +   D + +A+ LQ R++ L+++     
Sbjct: 1638 RRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSE 1697

Query: 392  FQLPSRQPALSSFLGHLAA--QVQAALR---RGATQQASGDDTHTPLRMEPRLLEPTAQD 446
             +  + Q  +    G LA   + + ALR   RG T+          L      L  T   
Sbjct: 1698 VKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEA---------LAQSSASLNSTRDK 1748

Query: 447  SLHV--SITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDL 504
            +LH+  ++T  +    ++Q LQ+ ++A  AR  + EA+ Q     + EQ Q L+ +  DL
Sbjct: 1749 NLHLQKALTACE---HDRQVLQERLDA--ARQALSEARKQS--SSLGEQVQTLRGEVADL 1801

Query: 505  TPLVGQLSLGQLQEVSKAL-QDTLASAGQIPFHAEPPETIRSLQERIKSLNLSL------ 557
              L    + GQLQ++ + L Q     A  +    +  +  R LQER+ SL  +L      
Sbjct: 1802 E-LQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAE 1860

Query: 558  -KEITTKVCMSEKFCSTLRKKVNDIETQ 584
             +E+       EK    LR+ ++ +E +
Sbjct: 1861 KREVERSALRLEKDRVALRRTLDKVERE 1888



 Score = 35.0 bits (79), Expect = 0.23
 Identities = 39/158 (24%), Positives = 72/158 (45%), Gaps = 8/158 (5%)

Query: 347  QMEVISLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLG 406
            +++ +    +LQ+L+E   +  + + A      ++ L+ E+  L  +L S Q AL+    
Sbjct: 1802 ELQRVEAEGQLQQLREVLRQRQEGEAAAL--NTVQKLQDERRLLQERLGSLQRALAQLEA 1859

Query: 407  HLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQ----EK 462
                  ++ALR    + A         R + R  E T +  L     R D  L     E 
Sbjct: 1860 EKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVR--LSAEKGRLDRTLTGAELEL 1917

Query: 463  QQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQ 500
             + Q++I+ L+A++ VLE      + E++ Q+QQL+ Q
Sbjct: 1918 AEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQ 1955



 Score = 34.3 bits (77), Expect = 0.39
 Identities = 64/308 (20%), Positives = 124/308 (40%), Gaps = 65/308 (21%)

Query: 375 TLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLR 434
           TL+  ++ LE   +     L +R  A  + +  L A ++  + R  +Q  S         
Sbjct: 14  TLETVIQTLESSVLCQEKGLGARDLAQDAQITSLPALIREIVTRNLSQPES--------- 64

Query: 435 MEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREI---- 490
             P LL  T   SL         L +E Q LQ+E+  ++  +    A+  +L  +     
Sbjct: 65  --PVLLPATEMASLLS-------LQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVS 115

Query: 491 EEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERI 550
           E  EQ L+ +  +L     +  + Q  E+ + LQ+  AS  +          +++ QE  
Sbjct: 116 ERLEQALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRR---------KLQAYQEGQ 166

Query: 551 KSLNLSLKEITTKVCMSEKFCSTLRKKV------------------NDIETQLPALLEAK 592
           +     ++ +  K+   +K CS L +++                   D+E+ L  L E +
Sbjct: 167 QRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQ 226

Query: 593 MHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRRE 652
             + S            ++ ++  E+    G  ++ L   S +++K   V  D+ R R+E
Sbjct: 227 QRSAS----------LAQVNAMLREQLDQAGSANQAL---SEDIRK---VTNDWTRCRKE 270

Query: 653 VEHQETAY 660
           +EH+E A+
Sbjct: 271 LEHREAAW 278


>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
          Length = 1498

 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 72/310 (23%), Positives = 127/310 (40%), Gaps = 46/310 (14%)

Query: 345  RRQMEVISLRLKLQKLQEDAVENDDYDKAETLQQ----------RLEDLEQEKISLHFQL 394
            ++QM+ I  +   QK+  +A   D   K + + +           L++L QE + +H + 
Sbjct: 835  KKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEK 894

Query: 395  PSRQPALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITR 454
             + +  LS  L    AQV+        Q  +  + H     + R    T   SL     +
Sbjct: 895  RTAEAELSR-LHREVAQVR--------QHMADLEGHLQSAQKERDEMETHLQSLQFDKEQ 945

Query: 455  RDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTP-------- 506
               + +  + L+K+IE LQ          Q+ R+ I EQ+Q+++  G DLT         
Sbjct: 946  MVAVTEANEALKKQIEELQ----------QEARKAITEQKQKMRRLGSDLTSAQKEMKTK 995

Query: 507  ------LVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEI 560
                   VG LS  +LQE   A +   A  GQ+       ++  +L ERI++L   L+ +
Sbjct: 996  HKAYENAVGILS-RRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAV 1054

Query: 561  T-TKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNHF-WTAKDLTEEIRSLTSER 618
            + +K  + ++    +     ++E     +LE +        F    K L E  + L  E 
Sbjct: 1055 SHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALEL 1114

Query: 619  EGLEGLLSKL 628
            E  +G L+ L
Sbjct: 1115 EHEKGKLTGL 1124



 Score = 33.5 bits (75), Expect = 0.66
 Identities = 70/319 (21%), Positives = 116/319 (36%), Gaps = 50/319 (15%)

Query: 347 QMEVISLRLKLQ-KLQEDAVENDDY--DKAETLQQRLEDLEQEKISLHFQLPSRQPALSS 403
           Q+  +S +L+ Q +    + +  D    + +TL+Q   DLE+    L   L ++  +L+S
Sbjct: 441 QLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLAS 500

Query: 404 FLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLL---EPTAQDSLHVSITRRDWLLQ 460
                                S +D         RL+   E   +  L    T  D L Q
Sbjct: 501 ---------------------SNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHD-LRQ 538

Query: 461 EKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVS 520
           +   LQ +++ +Q     L +K +  + EI   +   QW          Q  L   QE  
Sbjct: 539 QMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWY---------QQQLALAQEAR 589

Query: 521 KALQDTLA--SAGQIPFHAEPPETIRSLQERIKSLNLSL-KEITTKVCMSEKFCSTLRKK 577
             LQ  +A    GQ+        T   L E +K  N+SL +++T     S K    +  +
Sbjct: 590 VRLQGEMAHIQVGQM--------TQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQ 641

Query: 578 VNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSR-NV 636
           +  IE  +    EA    I        +DL   +     ERE L+ +      L  +   
Sbjct: 642 LQGIEADM-LDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQ 700

Query: 637 KKLGSVKEDYNRLRREVEH 655
            KL  ++ D      + EH
Sbjct: 701 VKLTLLQRDQQLEALQQEH 719



 Score = 33.1 bits (74), Expect = 0.86
 Identities = 51/218 (23%), Positives = 90/218 (41%), Gaps = 37/218 (16%)

Query: 330  LRKWEPVLRDCLLRNRRQMEVISLRLKLQKLQEDAVENDDYDK--AETLQQRLEDLEQEK 387
            LR+   +L   L +  R+ +++ L L++Q + +   E D   K   + LQ  LE  +++ 
Sbjct: 1131 LREHNSILETALAK--READLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKV 1188

Query: 388  ISLHFQLPSRQ----------PALSSFLGHLAAQVQAALRRGATQQASGDDTH------- 430
             SL  Q+ + +           A S  L  +  ++QA        QA  DD         
Sbjct: 1189 NSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHS 1248

Query: 431  ----------TPLRMEPRLLEPTAQDSLH---VSITRRDWLLQEKQQLQKEIEALQARMF 477
                         R + +LL+    + L    V     + L  E  Q ++EI++L+ +  
Sbjct: 1249 QEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQ-- 1306

Query: 478  VLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQ 515
             L+  +QQ R+E+E  +Q LQ    +L      LS+ Q
Sbjct: 1307 -LDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQ 1343



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 58/277 (20%), Positives = 111/277 (40%), Gaps = 35/277 (12%)

Query: 380 LEDLEQEKISLHFQLPSRQPALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRL 439
           LE L+ E +SL  QL   Q       G +AAQ+Q        Q+A+       ++    +
Sbjct: 610 LEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAA----FMQIQEAKTM 665

Query: 440 LEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQW 499
           +E   Q        R +    E+++LQ+  ++  +    LE + +Q++  + +++QQL+ 
Sbjct: 666 VEEDLQ-------RRLEEFEGERERLQRMADSAAS----LEQQLEQVKLTLLQRDQQLEA 714

Query: 500 QGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKE 559
              +   L+ QL+L Q     +ALQ                +++ +LQ     L   L E
Sbjct: 715 LQQEHLDLMKQLTLTQ-----EALQSR-------------EQSLDALQTHYDELQARLGE 756

Query: 560 ITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNHFWT--AKDLTEEIRSLTSE 617
           +  +    E     L+ +   +E  L A    K     G        ++ +E +  L  E
Sbjct: 757 LQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREE 816

Query: 618 REGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVE 654
                G +  L   ++   K++  +KE + + +  VE
Sbjct: 817 LAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVE 853



 Score = 30.4 bits (67), Expect = 5.6
 Identities = 61/292 (20%), Positives = 116/292 (39%), Gaps = 40/292 (13%)

Query: 373 AETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQVQAALRRGATQQASGDDTHTP 432
           AET ++ L+ L+ EK+ L  QL +           L+ +   AL+  A  QA      T 
Sbjct: 401 AETQEEMLQVLK-EKMRLEGQLEA-----------LSLEASQALKEKAELQAQLAALSTK 448

Query: 433 LRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEE 492
           L+ +         +  H S  R+D        L  E++ L+   + LE     L+  +E 
Sbjct: 449 LQAQV--------ECSHSSQQRQD-------SLSSEVDTLKQSCWDLERAMTDLQNMLEA 493

Query: 493 QEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLAS--AGQIPFHAEPPETIRSLQERI 550
           +   L     DL     Q++  Q Q +   ++D   S  +     H +  + + +LQ ++
Sbjct: 494 KNASLASSNNDL-----QVAEEQYQRLMAKVEDMQRSMLSKDNTVH-DLRQQMTALQSQL 547

Query: 551 KSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEE 610
           + + L    +T+K+  S+   S+L+      + QL    EA++             +T+ 
Sbjct: 548 QQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQA 607

Query: 611 --IRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAY 660
             +  L  E   L     +L     R++K+ G +      +  ++  QE A+
Sbjct: 608 GLLEHLKLENVSLS---QQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAF 656


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 82/340 (24%), Positives = 135/340 (39%), Gaps = 48/340 (14%)

Query: 337 LRDCLLRNRRQMEVISLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPS 396
           L   LL   RQ+     RLK Q+        D   +   LQ +L  LE++          
Sbjct: 419 LHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQL--------K 470

Query: 397 RQPALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQD--SLHVSITR 454
            +   S+ L H   Q+    ++   QQA    T   LR     LE   +        I  
Sbjct: 471 EKVTNSTELQH---QLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQN 527

Query: 455 RDWLLQEKQQ----LQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQ 510
            + LLQ+ ++    L+KE E L A++   E +   L  +++E+   LQ Q   LT     
Sbjct: 528 LEALLQKSKENISLLEKEREDLYAKIQAGEGETAVL-NQLQEKNHTLQEQVTQLTE---- 582

Query: 511 LSLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKF 570
             L    E  K  Q+ L    Q     E    +R+ Q+R+ SL  S+ E+ +++  S   
Sbjct: 583 -KLKNQSESHKQAQENLHDQVQ-----EQKAHLRAAQDRVLSLETSVNELNSQLNES--- 633

Query: 571 CSTLRKKVNDIETQLPALLEAKMHAISG---------NHFWTA----KDLTEEIRSLTSE 617
               ++KV+ ++ Q+ A  E  + A +          NH  TA    +D  +E+  +T++
Sbjct: 634 ----KEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQ 689

Query: 618 REGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQE 657
            + +   L       S+    L   KE Y  L ++ E  E
Sbjct: 690 LDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELE 729



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 61/333 (18%), Positives = 133/333 (39%), Gaps = 46/333 (13%)

Query: 355 LKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQV-- 412
           L+ Q+ + D +  D   + ++L+Q+LE+ + E    +F +   +         LA ++  
Sbjct: 119 LQQQEAKPDGLVTDSSAELQSLEQQLEEAQTE----NFNIKQMKDLFEQKAAQLATEIAD 174

Query: 413 -------QAALRRGATQQASG------------DDTHTPLRMEPRLLEPTA--QDSLHVS 451
                  + +LR  A Q+ +              D  T L   P + +     ++ + V 
Sbjct: 175 IKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQ 234

Query: 452 ITRRDWLLQ---EKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLV 508
               +  L+   E ++L+ E + LQ++    EA   QLR E+ +  Q++     +L  L 
Sbjct: 235 TLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKL- 293

Query: 509 GQLSLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSE 568
            + S+ +L + ++ L + L    Q             L+E+    ++S K I   +   +
Sbjct: 294 -KSSVNELTQKNQTLTENLLKKEQ---------DYTKLEEKHNEESVSKKNIQATLHQKD 343

Query: 569 KFCSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKL 628
             C  L+ +++  ET L      ++H          + L EE+  + ++ + L+    +L
Sbjct: 344 LDCQQLQSRLSASETSL-----HRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQL 398

Query: 629 LVLSSRNVKKLGSVKEDYNRLRREVEHQETAYG 661
                   +    ++ + N+L  ++   E   G
Sbjct: 399 QQQREEKEQHGLQLQSEINQLHSKLLETERQLG 431



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 50/238 (21%), Positives = 101/238 (42%), Gaps = 15/238 (6%)

Query: 361  QEDAVENDDYD-KAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQVQAALRRG 419
            QE  +++++ + + +T    L+ ++ EK +L  +L + +  LS     L        +  
Sbjct: 821  QETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKEN 880

Query: 420  ATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQ---QLQKEIEALQARM 476
               +A+  D     +     L+   +++L      +  L +EK+   QL+ E+ ++Q ++
Sbjct: 881  QKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQL 940

Query: 477  FVL-------EAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQ--EVSKALQDTL 527
                      E ++QQL+  I E +Q  + +   +  L G+L +  LQ  E+   LQ  L
Sbjct: 941  IQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQL 1000

Query: 528  ASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQL 585
              A Q    A   E I  LQ   +    + K++ +     E      R+ +  +E +L
Sbjct: 1001 TQAAQ--ELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKL 1056



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 61/315 (19%), Positives = 136/315 (43%), Gaps = 47/315 (14%)

Query: 341  LLRNRRQMEVISLRLKLQKLQEDAVENDDYDKAETLQQR---LEDLEQEKISLHFQLPSR 397
            L+ NR Q+   +  ++  K  +  +E D   K + LQ+R   L+D+++EK     +L + 
Sbjct: 1063 LISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNE 1122

Query: 398  QPALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDW 457
            +  L+        +++    +  T+      +H   ++E        +D+       +  
Sbjct: 1123 KSKLAEI-----EEIKCRQEKEITKLNEELKSH---KLESIKEITNLKDA-------KQL 1167

Query: 458  LLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQ 517
            L+Q+K +LQ + ++L+A +   +   Q L+ +++++E++L+ +  +    +      +++
Sbjct: 1168 LIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLH----SEIK 1223

Query: 518  EVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKK 577
            E    ++             +  E    L  +I +LN +L  +  +   S++  S L K+
Sbjct: 1224 EKEVGMK-------------KHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQ 1270

Query: 578  VNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVK 637
             +D+  ++ A+LEA           T ++  +E R+L       EG + KL        +
Sbjct: 1271 TDDLRGEI-AVLEA-----------TVQNNQDERRALLERCLKGEGEIEKLQTKVLELQR 1318

Query: 638  KLGSVKEDYNRLRRE 652
            KL +       L RE
Sbjct: 1319 KLDNTTAAVQELGRE 1333



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 63/293 (21%), Positives = 115/293 (39%), Gaps = 36/293 (12%)

Query: 356 KLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISL---HFQLPSRQPALSSFLGHLAAQV 412
           +LQKL+     N+   K +TL + L   EQ+   L   H +    +  + + L       
Sbjct: 289 ELQKLKSSV--NELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDC 346

Query: 413 QAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEAL 472
           Q    R +  + S    H  L  +    +   ++   V  T+   L  E +QLQ++ E  
Sbjct: 347 QQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVE-TKYQHLKAEFKQLQQQREEK 405

Query: 473 QARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQ 532
           +     L+++  QL  ++ E E+QL           G+ + G+L+E  +   + L     
Sbjct: 406 EQHGLQLQSEINQLHSKLLETERQL-----------GE-AHGRLKEQRQLSSEKL----- 448

Query: 533 IPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAK 592
                +  + +  LQ ++  L   LKE   KV  S +    L K     + Q     +A 
Sbjct: 449 ----MDKEQQVADLQLKLSRLEEQLKE---KVTNSTELQHQLDKTKQQHQEQ-----QAL 496

Query: 593 MHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKED 645
             + +        DL + +R +  + + ++  L  LL  S  N+  L   +ED
Sbjct: 497 QQSTTAKLREAQNDLEQVLRQIGDKDQKIQN-LEALLQKSKENISLLEKERED 548


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 54/187 (28%), Positives = 85/187 (45%), Gaps = 25/187 (13%)

Query: 352  SLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSF--LGHLA 409
            S RL  Q++QE   E  +Y++ +      ++LE+EK SL   L  ++  L        + 
Sbjct: 1025 SQRLVEQEVQEKLRETQEYNRIQ------KELEREKASLTLSLMEKEQRLLVLQEADSIR 1078

Query: 410  AQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEI 469
             Q  +ALR+   Q+A G+      +ME  LL    ++         D+L QE Q L+ E+
Sbjct: 1079 QQELSALRQDM-QEAQGEQKELSAQME--LLRQEVKEK------EADFLAQEAQLLE-EL 1128

Query: 470  EA-------LQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKA 522
            EA       L+A ++  EAK  QL+  +   E QL+    +  P     +  QL  +  A
Sbjct: 1129 EASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSA 1188

Query: 523  LQDTLAS 529
            LQ  L S
Sbjct: 1189 LQQALGS 1195



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 41/161 (25%), Positives = 80/161 (49%), Gaps = 8/161 (4%)

Query: 345  RRQMEVISLRLKLQKLQEDAVE---NDDYDKAET-LQQRLEDLEQEKISLHFQLPSRQPA 400
            R +ME + +RLK Q+ + +A++    ++  +AE+ L Q   + E+E++SL   L   Q  
Sbjct: 882  REKME-LEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKE 940

Query: 401  LSSFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQ---DSLHVSITRRDW 457
            L+     L    Q    +   +Q +     T L+   R L+  A+   D L         
Sbjct: 941  LADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSS 1000

Query: 458  LLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQ 498
            LLQ+K  LQK++E L++++   +   + + +E++E+ ++ Q
Sbjct: 1001 LLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQ 1041



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 87/355 (24%), Positives = 147/355 (41%), Gaps = 56/355 (15%)

Query: 346  RQMEVISLRLKLQKLQED-AVENDDYDKAETL--QQRLEDLEQEKISLHFQLPSRQPALS 402
            R  E+   + + ++L+E+ AVE       E +    R E  EQEK  L  Q    + A  
Sbjct: 1857 RHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQE 1916

Query: 403  SFLGHLAAQ-----VQAALR-RGATQQASGDDTHTPLRMEP--RLLEPTAQDSL---HVS 451
              +   A Q      QA L+ R    +A   ++ +    E   R      Q++L   H +
Sbjct: 1917 HEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAA 1976

Query: 452  ITRRDWLLQEKQQLQKEIEA----LQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPL 507
            +  ++  L E+ +L + +EA    LQA +   +A  +QL   +  QE ++Q Q  DL   
Sbjct: 1977 LQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQ--DL--- 2031

Query: 508  VGQLSLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMS 567
                   + QE  + LQ  LA         +  E +R  QER + L  SL +   +  + 
Sbjct: 2032 -------RYQEDVQQLQQALA---------QRDEELRHQQEREQLLEKSLAQRVQENMIQ 2075

Query: 568  EKFCSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSL--TSEREGLEGL- 624
            EK      ++  +I     ++ E ++         T     +EI  L  T +R  LE L 
Sbjct: 2076 EKQNLGQEREEEEIRGLHQSVRELQL---------TLAQKEQEILELRETQQRNNLEALP 2126

Query: 625  -LSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAYGYKYCDAESWTQRSQQLA 678
               K   +  +++K L S++    RL+RE+E  + A          W +++Q LA
Sbjct: 2127 HSHKTSPMEEQSLK-LDSLEP---RLQRELERLQAALRQTEAREIEWREKAQDLA 2177



 Score = 37.7 bits (86), Expect = 0.035
 Identities = 74/352 (21%), Positives = 144/352 (40%), Gaps = 56/352 (15%)

Query: 338  RDCLLRNRRQMEVISLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSR 397
            ++ L+R +  +EV        +LQ  AVE D  D AE LQ      E  + SL F+   +
Sbjct: 731  KEALVREKAALEV--------RLQ--AVERDRQDLAEQLQGLSSAKELLESSL-FEAQQQ 779

Query: 398  QPALSSFLGHLAAQVQAALRRGATQQASGD--------DTHTPLRMEPR----------- 438
               +    G L  Q+Q   +  A +   G+        DT      + R           
Sbjct: 780  NSVIEVTKGQLEVQIQTVTQ--AKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAE 837

Query: 439  ------LLEPTAQDSLHVSITRRDWLLQE---KQQLQKEIEALQARMFVLEAKDQQLRRE 489
                  L +  A     V+  R  W  +    +Q+L K +E+L+     LE + ++ + E
Sbjct: 838  QEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTE 897

Query: 490  IEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQER 549
            +E  + Q + +       + Q+ L   +E    L+  L +  ++   A+  + +  L++ 
Sbjct: 898  MEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKEL---ADASQQLERLRQD 954

Query: 550  IKSLNLSLKEITTKVCMS--EKFCSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDL 607
            +K   L  +E TT +  +  ++    L++        L AL E      S +      DL
Sbjct: 955  MKVQKLKEQE-TTGILQTQLQEAQRELKEAARQHRDDLAALQEE-----SSSLLQDKMDL 1008

Query: 608  TEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETA 659
             +++  L S+    +   S+ LV   + V++     ++YNR+++E+E ++ +
Sbjct: 1009 QKQVEDLKSQLVAQDD--SQRLV--EQEVQEKLRETQEYNRIQKELEREKAS 1056



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 51/250 (20%), Positives = 104/250 (41%), Gaps = 28/250 (11%)

Query: 455 RDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQ---LQWQGCDLTPLVGQL 511
           RD L  +   LQ E+++L     +L+   ++LR+++E  EQ+   L+    +L  L G  
Sbjct: 444 RDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVEL-QLQGDS 502

Query: 512 SLGQLQEVSKALQDTLASAGQIP-----FHAEPPETIR---SLQERIKSLNL-------S 556
           + GQ +E  + L   +    ++        A+  E++    +L+E ++S +L        
Sbjct: 503 AQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQE 562

Query: 557 LKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAK---------DL 607
             E+T  +  +E+  + L    N ++T++  L  A +   + N                L
Sbjct: 563 QTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQL 622

Query: 608 TEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAYGYKYCDA 667
            EE +S+ S  E  E   + L V  +   K+  ++ E    L  +++  E A      D 
Sbjct: 623 EEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADL 682

Query: 668 ESWTQRSQQL 677
               +  +++
Sbjct: 683 RDIQEEKEEI 692



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 61/317 (19%), Positives = 125/317 (39%), Gaps = 65/317 (20%)

Query: 348 MEVISLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPS---RQPALSSF 404
           ++ + L  +L +L+E+          +++  R+E  EQ + +L   L     R+ AL   
Sbjct: 610 LDKVGLNQQLLQLEEEN---------QSVCSRMEAAEQARNALQVDLAEAEKRREALWEK 660

Query: 405 LGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQ 464
             HL AQ+Q A   GA  QA   D                             + +EK++
Sbjct: 661 NTHLEAQLQKAEEAGAELQADLRD-----------------------------IQEEKEE 691

Query: 465 LQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSL--GQLQEVSKA 522
           +QK++   + +      + +QL +E + QE+ L     +   LV + +    +LQ V + 
Sbjct: 692 IQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERD 751

Query: 523 LQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIE 582
            QD                    L E+++ L+ + + + + +  +++  S +      +E
Sbjct: 752 RQD--------------------LAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLE 791

Query: 583 TQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSV 642
            Q+  + +AK   I G       +L  E      ER+     L++        +++  + 
Sbjct: 792 VQIQTVTQAK-EVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAA 850

Query: 643 KE-DYNRLRREVEHQET 658
            E + N+LR + E + +
Sbjct: 851 HEKEVNQLREKWEKERS 867



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 48/191 (25%), Positives = 80/191 (41%), Gaps = 43/191 (22%)

Query: 338  RDCLLRNRRQMEVISLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSR 397
            RD  LR++++ E +  +   Q++QE+ ++       E  ++ +  L Q    L   L  +
Sbjct: 2047 RDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQK 2106

Query: 398  QPALSSFLGHLAAQVQAALRRGATQQASGDD----THTPLRMEPRLLEPTAQDSLHVSIT 453
            +              Q  L    TQQ +  +    +H    ME + L+    DSL     
Sbjct: 2107 E--------------QEILELRETQQRNNLEALPHSHKTSPMEEQSLK---LDSL----- 2144

Query: 454  RRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSL 513
                    + +LQ+E+E LQA +   EA      REIE +E+    Q   L+    + S+
Sbjct: 2145 --------EPRLQRELERLQAALRQTEA------REIEWREKA---QDLALSLAQTKASV 2187

Query: 514  GQLQEVSKALQ 524
              LQEV+  LQ
Sbjct: 2188 SSLQEVAMFLQ 2198



 Score = 31.2 bits (69), Expect = 3.3
 Identities = 67/309 (21%), Positives = 123/309 (39%), Gaps = 44/309 (14%)

Query: 326  WDTLLRKWEPVLRDCLLRNRRQM-----EVISLRLKLQKLQEDAVENDDYDKAETLQQRL 380
            W T  ++   VLRD + +   ++     E   +  +LQ LQ    +N +  +    + + 
Sbjct: 1253 WKT--QQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQE--EKSKWEGKQ 1308

Query: 381  EDLEQEKISLHFQLPSRQPALS-SFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRL 439
              LE E + LH  + S Q  L  + L  + AQ +  L + A +  +    H    +    
Sbjct: 1309 NSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEAR 1368

Query: 440  LEPTAQDSLHVSI-TRRDWLLQEKQQLQKEIE-----------------ALQARMFVL-- 479
             + +A   L   + T R  L  + ++++ E E                 ALQ  + +L  
Sbjct: 1369 AQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQ 1428

Query: 480  -----EAKDQQLRREIEEQEQQLQWQGCDLTPLVGQL-----SLGQLQEVSKALQDTLAS 529
                 E + + LR +I+E E+Q + Q   L  L   L      +   QE  + L+   + 
Sbjct: 1429 TLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSV 1488

Query: 530  AGQIPFHAEPPETIRSLQ-ERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPAL 588
               +P   +  E   ++Q E+I+ L    K+  T+  + E     L KK   IE+Q   +
Sbjct: 1489 LEHLPMAVQEREQKLTVQREQIRELE---KDRETQRNVLEHQLLELEKKDQMIESQRGQV 1545

Query: 589  LEAKMHAIS 597
             + K   ++
Sbjct: 1546 QDLKKQLVT 1554



 Score = 30.0 bits (66), Expect = 7.3
 Identities = 50/247 (20%), Positives = 106/247 (42%), Gaps = 47/247 (19%)

Query: 376  LQQRLEDLEQEKISLHFQLPSRQPALSSF---LGHLAAQVQAALRRGATQQASGDDTHTP 432
            LQ+  + LEQ+   LH ++      LS     +  L  Q+Q A  +G  ++ S       
Sbjct: 1748 LQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQS------- 1800

Query: 433  LRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEE 492
              ++ +L E  AQ +L       + L QE+QQ Q + E ++ +   L+   +Q    ++E
Sbjct: 1801 --LQSQLDE--AQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKE 1856

Query: 493  QEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKS 552
            +  +LQ                  +E ++ L++ LA  G+          +++L+E +  
Sbjct: 1857 RHGELQ----------------DHKEQARRLEEELAVEGR---------RVQALEEVLGD 1891

Query: 553  LNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIR 612
            L    +E    +   ++ C+   ++  + E +  AL ++ + A +       K+  +E+ 
Sbjct: 1892 LRAESREQEKALLALQQQCA---EQAQEHEVETRALQDSWLQAQA-----VLKERDQELE 1943

Query: 613  SLTSERE 619
            +L +E +
Sbjct: 1944 ALRAESQ 1950


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 83/397 (20%), Positives = 176/397 (44%), Gaps = 63/397 (15%)

Query: 326  WDTLLRKWEPVLRDCLLRNRRQMEVISLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQ 385
            W  L  K +P+L+       R+ E+ S++ +  +L+E A+E  +  + E L++++  L Q
Sbjct: 829  WMKLYFKIKPLLKSA----EREKEMASMKEEFTRLKE-ALEKSEARRKE-LEEKMVSLLQ 882

Query: 386  EKISLHFQLPSRQPALSSF------LGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRL 439
            EK  L  Q+ + Q  L+        L     Q++A ++    +    ++ +  L  + R 
Sbjct: 883  EKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRK 942

Query: 440  LEPTAQ------DSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLE---AKDQQLRREI 490
            LE          D L +++ + +   +EK   + +++ L   M  L+   AK  + ++ +
Sbjct: 943  LEDECSELKRDIDDLELTLAKVE---KEKHATENKVKNLTEEMAGLDEIIAKLTKEKKAL 999

Query: 491  EEQEQQ----LQWQGCDLTPLV-GQLSL--------GQLQEVSKALQDTLASAGQIPFHA 537
            +E  QQ    LQ +   +  L   ++ L        G L++  K   D   +  ++    
Sbjct: 1000 QEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDL 1059

Query: 538  E-PPETIRSLQ-------ERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPAL- 588
            +   E+I  L+       ER+K  +  L  +  ++   +   S L+KK+ +++ ++  L 
Sbjct: 1060 KLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELE 1119

Query: 589  --LEAKMHAISGNHFWTAKDLTEEIRS-LTSEREGLEGLLSKLLVLSSRNVKKLGSVKED 645
              LEA+          TA+   E++RS L+ E E +   L +    +S  ++     + +
Sbjct: 1120 EELEAER---------TARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAE 1170

Query: 646  YNRLRREVE-----HQETAYGYKYCDAESWTQRSQQL 677
            + ++RR++E     H+ TA   +   A+S  +  +Q+
Sbjct: 1171 FQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQI 1207



 Score = 35.4 bits (80), Expect = 0.17
 Identities = 37/199 (18%), Positives = 84/199 (42%), Gaps = 16/199 (8%)

Query: 458  LLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQ 517
            L Q  Q+ ++ +EA+ A+   LE    +L+ EIE+    ++             +   L 
Sbjct: 1393 LAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNA---------AAAALD 1443

Query: 518  EVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKK 577
            +  +     LA   Q   + E    + S Q+  +SL+  L ++      S +   T +++
Sbjct: 1444 KKQRNFDKILAEWKQ--KYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRE 1501

Query: 578  VNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVK 637
              +++ ++  L E       G+   T  +L +  + L +E+  L+  L +          
Sbjct: 1502 NKNLQEEISDLTEQ-----LGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEG 1556

Query: 638  KLGSVKEDYNRLRREVEHQ 656
            K+   + ++N+++ E+E +
Sbjct: 1557 KILRAQLEFNQIKAEIERK 1575


>gi|10440566 leucine zipper, putative tumor suppressor 1 [Homo
           sapiens]
          Length = 596

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 84/338 (24%), Positives = 141/338 (41%), Gaps = 50/338 (14%)

Query: 274 SADLAQAARNSSRPERDMHSLPDMDPGSSSSLDPSLAGCGGDGSSGSGDAHSWDTLLRKW 333
           S  L+ + RNS      M SLP     SS  LDP +   G     G G AH+    +   
Sbjct: 168 SGALSDSGRNS------MSSLPTHSTSSSYQLDPLVTPVGPTSRFG-GSAHNITQGI--- 217

Query: 334 EPVLRDCLLRNRRQMEVISLRLKLQKLQE---------DAVENDDYDKAETLQQRLEDLE 384
             VL+D  + + + +       KL    +           +  D+    E L+Q+L  LE
Sbjct: 218 --VLQDSNMMSLKALSFSDGGSKLGHSNKADKGPSCVRSPISTDECSIQE-LEQKL--LE 272

Query: 385 QEKISLHFQLPSRQPALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTA 444
           +E      Q    +  L+S L +     +        +   G+      +   R     A
Sbjct: 273 REGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQKSQR-----A 327

Query: 445 QDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRRE---IEEQEQQLQWQG 501
           Q  LH+ + +   L QEK+QL++E+E+L     +LE K +   RE        ++ QW+ 
Sbjct: 328 QQVLHLQVLQ---LQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEV 384

Query: 502 CDLTPLVGQLSLGQLQEVSKALQDTLASAGQI-PFHAEPPET---IRSLQERIKSLN--L 555
           C  +   G++SL + Q++ ++  +  A A +I    A+  +T   +  L+ R + L   L
Sbjct: 385 CQKS---GEISLLK-QQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQDLEGAL 440

Query: 556 SLKEITTKVCMSE-----KFCSTLRKKVNDIETQLPAL 588
             K +  +VC +E          LR+KVN +E +L  L
Sbjct: 441 RTKGLELEVCENELQRKKNEAELLREKVNLLEQELQEL 478



 Score = 31.2 bits (69), Expect = 3.3
 Identities = 47/190 (24%), Positives = 81/190 (42%), Gaps = 40/190 (21%)

Query: 337 LRDCLLRNRRQMEVISLR-------LKLQKLQEDAVEND---DYDKAETLQQRLEDLEQE 386
           L+  L   R ++E + LR       L+ + L+ +  EN+     ++AE L++++  LEQE
Sbjct: 415 LKAQLKDTRGKLEGLELRTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQE 474

Query: 387 KISLHFQ-----------LPSRQPALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLRM 435
              L  Q            P   PAL   L  L A+++   R+G  Q +SG         
Sbjct: 475 LQELRAQAALARDMGPPTFPEDVPALQRELERLRAELREE-RQGHDQMSSG--------- 524

Query: 436 EPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRR-EIEEQE 494
                    Q    V    ++ ++Q ++QLQ+   A+  R   LE   QQL R +   + 
Sbjct: 525 --------FQHERLVWKEEKEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAGEP 576

Query: 495 QQLQWQGCDL 504
            ++  +G D+
Sbjct: 577 LEVDLEGADI 586


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 70/356 (19%), Positives = 152/356 (42%), Gaps = 45/356 (12%)

Query: 344  NRRQMEVISL-RLKLQKLQE-----DAVENDDYDKAE---TLQQRLEDLEQEKISLHFQL 394
            +++++E+  + +L L+K ++       +E  D    E   ++ +++  L +EK SL  ++
Sbjct: 869  SQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEI 928

Query: 395  PSRQPALSSFLGHLAA---------QVQAALRRGATQQA-SGDDTHTPLRMEPRLLEPTA 444
             + +  L+       A         +V + L++   + + +G  +   L+ E  LL+   
Sbjct: 929  KTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKEN 988

Query: 445  QD---SLHVSITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQG 501
            +     L  ++  R  LLQ   +L++E+  L+          +  R E+EE ++  ++  
Sbjct: 989  EQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSE 1048

Query: 502  CDLTPLVGQLSLG----------QLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIK 551
              +T    ++ +           +LQ + K L++ LA+  Q  F A   +  ++LQ++  
Sbjct: 1049 KCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQ--FQALVKQMNQTLQDKTN 1106

Query: 552  SLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEI 611
             ++L   EI+    + +K  ++     +     L           +G+      +L E+I
Sbjct: 1107 QIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKI 1166

Query: 612  RSLTSEREGLEGLLSKLLVLSSRNVKK-----------LGSVKEDYNRLRREVEHQ 656
             +L  E+E L+  L + L      +KK           L   K+DYNRL+ + + Q
Sbjct: 1167 LALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQ 1222



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 70/344 (20%), Positives = 142/344 (41%), Gaps = 29/344 (8%)

Query: 338  RDCLLRNRRQMEVISLRLKLQK---LQEDAVENDDY-DKAETLQQRLEDLEQEKISLHFQ 393
            RD ++ + +Q+E   L + L+K   +QE A EN+   ++   L+  ++DL  E   L  +
Sbjct: 2473 RDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAE 2532

Query: 394  LPSRQPALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSIT 453
            L   +  L+  +    +Q +  L     Q    ++ +  L  + +  E   +D       
Sbjct: 2533 LIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANED------L 2586

Query: 454  RRDW--LLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQL 511
            RR +  L +EKQ L KEIE+L+  +        QL R++   +++           V + 
Sbjct: 2587 RRSFNALQEEKQDLSKEIESLKVSI-------SQLTRQVTALQEEGTLGLYHAQLKVKEE 2639

Query: 512  SLGQLQEVSKALQDTLASAGQ--IPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEK 569
             + +L  +  + Q  +A   +  +    E  + +  +++++K     LK +     +   
Sbjct: 2640 EVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKK---ELKHLHHDAGIMRN 2696

Query: 570  FCSTLRKKVNDIETQLPALLEAKMHAISGNHFWTA--KDLTEEIRSLTSEREGLEGLLSK 627
               T  ++V ++   L  + +  +     N   TA  +     + SL + R+     L +
Sbjct: 2697 ETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDE 2756

Query: 628  LLVLSSRNVKKLGSVKED--YNRLRREVEHQETAYGYKYCDAES 669
            L      ++K+L  +KE    NR  R+    ETA+     +  S
Sbjct: 2757 LKRKYDASLKELAQLKEQGLLNR-ERDALLSETAFSMNSTEENS 2799



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 58/273 (21%), Positives = 117/273 (42%), Gaps = 33/273 (12%)

Query: 347 QMEVISLRLKLQKLQE-DAVENDDYDKAETLQQRLEDLEQEK-ISLHFQLPSRQPALSSF 404
           +ME+  ++ KLQ+ +E  +       +A+  Q      E E+ + +  QL  ++  +S+ 
Sbjct: 143 EMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTL 202

Query: 405 LGHLA-AQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQ 463
              L+  Q + A ++   ++ +  +T   L  E  LL+   Q  +   + ++  +LQ K 
Sbjct: 203 QAQLSQTQAEQAAQQVVREKDARFETQVRLH-EDELLQLVTQADVETEMQQKLRVLQRKL 261

Query: 464 Q---------------LQKEIEALQARMFVLEAKDQQLRRE---------IEEQEQQLQW 499
           +               LQ+E+ A + R  +L  + QQ+  E          E +E ++  
Sbjct: 262 EEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILL 321

Query: 500 QGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKE 559
           +  +L     +LS   LQE    L +    AGQ    AE      +L+++ K+    ++E
Sbjct: 322 EKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQA--QAELESRYSALEQKHKA---EMEE 376

Query: 560 ITTKVCMSEKFCSTLRKKVNDIETQLPALLEAK 592
            T+ +   +K    L+   + ++ Q   LL+ K
Sbjct: 377 KTSHILSLQKTGQELQSACDALKDQNSKLLQDK 409



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 79/366 (21%), Positives = 142/366 (38%), Gaps = 71/366 (19%)

Query: 350  VISLRLKLQK---LQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLG 406
            V++  LKL+K     +++V++    K E L++RLE  E++ +     +  +  AL     
Sbjct: 2094 VLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKV 2153

Query: 407  HLA---AQVQAALRRGATQ----QASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDW-- 457
            HL     ++Q  L +   +    Q + D T T L    + +     D   V    + W  
Sbjct: 2154 HLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWER 2213

Query: 458  ----------------------LLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQ 495
                                  L  + +Q+   +E L+  +  LE  D+Q+     + E 
Sbjct: 2214 KFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLE-HDKQIWESKAQTEV 2272

Query: 496  QLQWQGCDL-----TPLVGQL------------SLGQLQEVSKALQDTLASAGQIPFHAE 538
            QLQ + CD        L+ QL             L +L+   K+L+D L          +
Sbjct: 2273 QLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCK 2332

Query: 539  PPE-----TIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKM 593
              +      IR  +  I++   S +++ T +  S +  S L +++N  E ++ +LL  K 
Sbjct: 2333 EQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKE 2392

Query: 594  HAISGNHFWTAKDLTEEIRSLTSEREGLEGLLS----KLLVLSSRN---VKKLGSVKEDY 646
             AI          + E  +    E + LE LLS    + +VL   N   V K   + E  
Sbjct: 2393 EAIQ-------VAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETL 2445

Query: 647  NRLRRE 652
              +++E
Sbjct: 2446 KTIKKE 2451



 Score = 36.6 bits (83), Expect = 0.078
 Identities = 36/143 (25%), Positives = 66/143 (46%), Gaps = 20/143 (13%)

Query: 460  QEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEV 519
            QEKQ+L  ++ + +A     E + Q+  +E+EE +++++           Q  + +L+E 
Sbjct: 1641 QEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMR-----KFAKSKQQKILELEEE 1695

Query: 520  SKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVN 579
            +  L+  +  AG         +T +   E + S N S+KE   +V M  +   TL KK  
Sbjct: 1696 NDRLRAEVHPAG---------DTAKECMETLLSSNASMKEELERVKMEYE---TLSKKFQ 1743

Query: 580  DIETQLPALLEAKM---HAISGN 599
             + ++  +L E      H I GN
Sbjct: 1744 SLMSEKDSLSEEVQDLKHQIEGN 1766



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 70/340 (20%), Positives = 144/340 (42%), Gaps = 37/340 (10%)

Query: 344  NRRQMEVISLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSS 403
            N    ++  L+ ++  L+E+  +N ++ +          LE EK +L  Q+ ++   L  
Sbjct: 1836 NNYLQQIDQLKERIAGLEEEKQKNKEFSQT---------LENEKNTLLSQISTKDGELKM 1886

Query: 404  F------LGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDW 457
                   +  L  Q+Q  L R    + + ++    L  E RL+   A+ +  +    +D 
Sbjct: 1887 LQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDL--EERLMNQLAELNGSIGNYCQDV 1944

Query: 458  LLQE--KQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQW------QGCDLTPLVG 509
               +   + L+ E++ L+  +  LE + QQL +E  + E +++       QG    P  G
Sbjct: 1945 TDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEP--G 2002

Query: 510  QLSLG-QLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSE 568
              S   +LQE+ K  Q  +    +     +  E I +L+  +K+L     E    + +++
Sbjct: 2003 NKSHAKELQELLKEKQQEVKQLQKDCIRYQ--EKISALERTVKALEFVQTESQKDLEITK 2060

Query: 569  KFCSTL---RKKVNDIETQLPALLE---AKMHAISGNHFWTAKDLTEEIRSLTSE-REGL 621
            +  +     RKK          LL+   ++   +  ++    K+L     S+ S+ ++  
Sbjct: 2061 ENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKD 2120

Query: 622  EGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAYG 661
            E L  +L     +++K+  +++E  + LRRE  H E   G
Sbjct: 2121 EDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIG 2160



 Score = 33.1 bits (74), Expect = 0.86
 Identities = 69/388 (17%), Positives = 154/388 (39%), Gaps = 56/388 (14%)

Query: 267  SLLATRVSADLAQAARNSSRPERDMHSLPDMDPGSSSSLDPSLAGCGGDGSSGSGDAHSW 326
            +LL  ++  +L++  +     E +   L +      + L+ S+    G+      DA   
Sbjct: 1895 NLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSI----GNYCQDVTDAQIK 1950

Query: 327  DTLLRKWEPVLRDC----------LLRNRRQMEVISLRLKLQKLQEDAVENDDYDKAETL 376
            + LL      L+ C          L++ + ++E    +  L+K+Q    E  +   A+ L
Sbjct: 1951 NELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKEL 2010

Query: 377  QQRLEDLEQEKISLHFQLPSRQPALSSF------LGHLAAQVQAALRRGATQQASGDDTH 430
            Q+ L++ +QE   L       Q  +S+       L  +  + Q  L       A   +  
Sbjct: 2011 QELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHR 2070

Query: 431  TPLRME----PRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQL 486
               + E      LL+ T  ++  V        L+ K++LQ   E+++++M   + KD+ L
Sbjct: 2071 KKAQAELASFKVLLDDTQSEAARVLADN----LKLKKELQSNKESVKSQM---KQKDEDL 2123

Query: 487  RREIEEQEQQ--------------LQWQGCDLTPLVG--QLSLGQLQEVSKALQDTL-AS 529
             R +E+ E++              L+ +   L   +G  Q++L +  +  + LQ+ L ++
Sbjct: 2124 ERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDST 2183

Query: 530  AGQIPFHAEPPETIRSLQERI--------KSLNLSLKEITTKVCMSEKFCSTLRKKVNDI 581
              Q+    +   +++  ++R+        +  + +++    ++ + E  CS L+ ++  +
Sbjct: 2184 VTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQM 2243

Query: 582  ETQLPALLEAKMHAISGNHFWTAKDLTE 609
               +  L             W +K  TE
Sbjct: 2244 SIHMEELKINISRLEHDKQIWESKAQTE 2271



 Score = 31.2 bits (69), Expect = 3.3
 Identities = 48/227 (21%), Positives = 96/227 (42%), Gaps = 33/227 (14%)

Query: 458  LLQEKQQLQKEI-EALQARMFVL---EAKDQQLRREIEEQ-------EQQLQWQGCDLTP 506
            L +EK+QLQK++ EAL +R  +L   + K++ LR E+++Q       ++Q   Q  +   
Sbjct: 1169 LEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENEN 1228

Query: 507  LVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCM 566
            +  QL   Q+Q V +++   L S  Q        E+  S     + L  + ++  T+  +
Sbjct: 1229 IGDQLRQLQIQ-VRESIDGKLPSTDQ-------QESCSSTPGLEEPLFKATEQHHTQPVL 1280

Query: 567  SEKFCSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLS 626
                C        D              A+ G    +   +  +++ + +E+  LE  +S
Sbjct: 1281 ESNLCPDWPSHSEDAS------------ALQGG--TSVAQIKAQLKEIEAEKVELELKVS 1326

Query: 627  KLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAYGYKYCDAESWTQR 673
                  ++  +++  ++E  N+   E+E  +T        AES  Q+
Sbjct: 1327 STTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQK 1373



 Score = 30.4 bits (67), Expect = 5.6
 Identities = 66/327 (20%), Positives = 120/327 (36%), Gaps = 43/327 (13%)

Query: 282  RNSSRPERDMHSLPDMDPGSSSSLDPSLAGCGGDGSSGSGDAHSWDTLLRKWEPVLRDCL 341
            R S   ++   + P   P    SL  +++    D           D LL++ + + +  L
Sbjct: 2856 RKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDR----------DRLLKELKNLQQQYL 2905

Query: 342  LRNRRQMEVISLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPAL 401
              N+   E+  L+ +LQ+ Q         DK +  Q   E+L QE +S   +L   +   
Sbjct: 2906 QINQEITELHPLKAQLQEYQ---------DKTKAFQIMQEELRQENLSWQHELHQLRMEK 2956

Query: 402  SSFLGH---LAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEP-------TAQDSLHVS 451
            SS+  H   +  Q   A+     Q +   +    LR      +P        A      S
Sbjct: 2957 SSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSAS 3016

Query: 452  ITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLR---REIEEQEQQLQWQGCDLTPLV 508
                  L+ E + L+ ++      +   E + QQL     ++ E++  L  Q CD +  +
Sbjct: 3017 PDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSL 3076

Query: 509  --GQLSLGQLQE----VSKALQDTLASAGQIPFHAEPPET-----IRSLQERIKSLNLSL 557
               Q   G L      + K +Q+  A    I      P+       +S  E ++    S 
Sbjct: 3077 RENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSF 3136

Query: 558  KEITTKVCMSEKFCSTLRKKVNDIETQ 584
             E   ++C + +  + LRK + +   Q
Sbjct: 3137 SEAQQQLCNTRQEVNELRKLLEEERDQ 3163


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 76/324 (23%), Positives = 126/324 (38%), Gaps = 52/324 (16%)

Query: 342  LRNRRQMEVISLRLKLQ---KLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQ 398
            LR +R+ EV  L+  L    +  E  V+      A+ +++  E LEQ K +    L   +
Sbjct: 1168 LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA-KANLDKNK 1226

Query: 399  PALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWL 458
              L      LA +++         QA  +  H   ++E ++ E   Q         R  L
Sbjct: 1227 QTLEKENADLAGELRVL------GQAKQEVEHKKKKLEAQVQE--LQSKCSDGERARAEL 1278

Query: 459  LQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQ-----WQGCDLTPLVGQLSL 513
              +  +LQ E+E++   +   E K  +L +++     QLQ      Q      L     L
Sbjct: 1279 NDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKL 1338

Query: 514  GQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCST 573
             QL+E   +LQD L          E  E  ++L+  I +LN+ L              S 
Sbjct: 1339 RQLEEERNSLQDQL---------DEEMEAKQNLERHISTLNIQL--------------SD 1375

Query: 574  LRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSS 633
             +KK+ D  + + AL E K            K   +EI +LT + E       KL    +
Sbjct: 1376 SKKKLQDFASTVEALEEGK------------KRFQKEIENLTQQYEEKAAAYDKLEKTKN 1423

Query: 634  RNVKKLGSVKEDYNRLRREVEHQE 657
            R  ++L  +  D +  R+ V + E
Sbjct: 1424 RLQQELDDLVVDLDNQRQLVSNLE 1447



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 73/346 (21%), Positives = 143/346 (41%), Gaps = 59/346 (17%)

Query: 343  RNRRQMEVISLRLKLQKLQEDAVENDDYD-----KAETLQQRLEDL------EQEKISLH 391
            R + Q+E ++   K++KL+++ +  DD +     + + L++R+ DL      E+EK    
Sbjct: 966  RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL 1025

Query: 392  FQLPSRQPALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVS 451
             +L ++  ++ S       +++  L++        + +   L    R LE  A D     
Sbjct: 1026 TKLKNKHESMIS-------ELEVRLKK-------EEKSRQELEKLKRKLEGDASDFHEQI 1071

Query: 452  ITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQL 511
               +  + + K QL K+ E LQA +        +L  EI ++   L+     +  L G +
Sbjct: 1072 ADLQAQIAELKMQLAKKEEELQAAL-------ARLDDEIAQKNNALK----KIRELEGHI 1120

Query: 512  SLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFC 571
            S          LQ+ L S       AE  +  R L E +++L   L++        ++  
Sbjct: 1121 S---------DLQEDLDSERAARNKAEKQK--RDLGEELEALKTELEDTLDSTATQQELR 1169

Query: 572  S------TLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLE--- 622
            +      T+ KK  D ET+     EA++  +   H    ++LTE++      +  L+   
Sbjct: 1170 AKREQEVTVLKKALDEETRSH---EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNK 1226

Query: 623  GLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAYGYKYCDAE 668
              L K     +  ++ LG  K++    ++++E Q      K  D E
Sbjct: 1227 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGE 1272



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 66/330 (20%), Positives = 130/330 (39%), Gaps = 34/330 (10%)

Query: 343  RNRRQMEVISLRLKLQKLQEDAVENDDYDKAET-LQQRLEDLEQEKISLHFQLPSRQPAL 401
            + R Q E+ +L    Q+ +E A   D  +K +  LQQ L+DL  + +    QL S     
Sbjct: 1394 KKRFQKEIENLT---QQYEEKAAAYDKLEKTKNRLQQELDDLVVD-LDNQRQLVSNLEKK 1449

Query: 402  SSFLGHLAAQVQAALRRGATQ----QASGDDTHTPLRMEPRLLEPTAQDSLHVSITRR-- 455
                  L A+ +    + A +    +A   +  T      R LE   +    +  T +  
Sbjct: 1450 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1509

Query: 456  ----DWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQ-WQGCDLTPLVGQ 510
                + L+  K  + K +  L+     LE + ++++ ++EE E +LQ  +   L   V  
Sbjct: 1510 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNM 1569

Query: 511  LSL-GQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEK 569
             +L GQ +   +A  +            +  E  R LQ ++      L++   +  ++  
Sbjct: 1570 QALKGQFERDLQARDE------------QNEEKRRQLQRQLHEYETELEDERKQRALAAA 1617

Query: 570  FCSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLL 629
                L   + D+E Q  + ++ +  AI        + L  +++    E E       ++ 
Sbjct: 1618 AKKKLEGDLKDLELQADSAIKGREEAIK-----QLRKLQAQMKDFQRELEDARASRDEIF 1672

Query: 630  VLSSRNVKKLGSVKEDYNRLRREVEHQETA 659
              +  N KK  S++ D  +L+ ++   E A
Sbjct: 1673 ATAKENEKKAKSLEADLMQLQEDLAAAERA 1702



 Score = 35.4 bits (80), Expect = 0.17
 Identities = 50/264 (18%), Positives = 108/264 (40%), Gaps = 40/264 (15%)

Query: 427  DDTHTPLRMEPRLLEPTAQDSLHVSITRRDW---LLQEKQQLQKEIEALQARMFVLEAKD 483
            +  H+ L  E  LL+   Q    +     +    L  +KQ+L++ +  ++AR+   E + 
Sbjct: 879  EQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRG 938

Query: 484  QQLRRE----------IEEQ--EQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAG 531
            QQL+ E          +EEQ  E++   Q   L  +  +  + +L++    + D      
Sbjct: 939  QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ----- 993

Query: 532  QIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLP----- 586
                + +  +  + L+ERI  L  +L E   K     K  +     ++++E +L      
Sbjct: 994  ----NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1049

Query: 587  ----ALLEAKMHAISGNHFWTAKDLTEEI----RSLTSEREGLEGLLSKL---LVLSSRN 635
                  L+ K+   + +      DL  +I      L  + E L+  L++L   +   +  
Sbjct: 1050 RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNA 1109

Query: 636  VKKLGSVKEDYNRLRREVEHQETA 659
            +KK+  ++   + L+ +++ +  A
Sbjct: 1110 LKKIRELEGHISDLQEDLDSERAA 1133



 Score = 33.1 bits (74), Expect = 0.86
 Identities = 64/277 (23%), Positives = 114/277 (41%), Gaps = 53/277 (19%)

Query: 338  RDCLLRNRRQMEVISLRLKLQK-LQEDAVENDDYDKAETL----QQRLE-DLEQEKISLH 391
            RD   R+ +  E    R +LQ+ L E   E +D  K   L    +++LE DL+  ++   
Sbjct: 1578 RDLQARDEQNEEK---RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1634

Query: 392  FQLPSRQPALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLR--------MEPRLLEPT 443
              +  R+ A+   L  L AQ++   R     +AS D+     +        +E  L++  
Sbjct: 1635 SAIKGREEAIKQ-LRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ-- 1691

Query: 444  AQDSLHVSITRRDWLLQEKQQLQKEI-------EALQARMFVLEAKDQQLRREIEEQEQQ 496
             Q+ L  +   R     EK++L +E+        ALQ     LEA+  QL  E+EE++  
Sbjct: 1692 LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1751

Query: 497  LQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLS 556
            ++                    V KA Q     + ++       +   S +++++  N  
Sbjct: 1752 ME---------------AMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN-- 1794

Query: 557  LKEITTKV-----CMSEKFCST---LRKKVNDIETQL 585
             KE+ +K+      +  KF ST   L  K+  +E Q+
Sbjct: 1795 -KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQV 1830


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 76/324 (23%), Positives = 126/324 (38%), Gaps = 52/324 (16%)

Query: 342  LRNRRQMEVISLRLKLQ---KLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQ 398
            LR +R+ EV  L+  L    +  E  V+      A+ +++  E LEQ K +    L   +
Sbjct: 1175 LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA-KANLDKNK 1233

Query: 399  PALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWL 458
              L      LA +++         QA  +  H   ++E ++ E   Q         R  L
Sbjct: 1234 QTLEKENADLAGELRVL------GQAKQEVEHKKKKLEAQVQE--LQSKCSDGERARAEL 1285

Query: 459  LQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQ-----WQGCDLTPLVGQLSL 513
              +  +LQ E+E++   +   E K  +L +++     QLQ      Q      L     L
Sbjct: 1286 NDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKL 1345

Query: 514  GQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCST 573
             QL+E   +LQD L          E  E  ++L+  I +LN+ L              S 
Sbjct: 1346 RQLEEERNSLQDQL---------DEEMEAKQNLERHISTLNIQL--------------SD 1382

Query: 574  LRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSS 633
             +KK+ D  + + AL E K            K   +EI +LT + E       KL    +
Sbjct: 1383 SKKKLQDFASTVEALEEGK------------KRFQKEIENLTQQYEEKAAAYDKLEKTKN 1430

Query: 634  RNVKKLGSVKEDYNRLRREVEHQE 657
            R  ++L  +  D +  R+ V + E
Sbjct: 1431 RLQQELDDLVVDLDNQRQLVSNLE 1454



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 73/346 (21%), Positives = 143/346 (41%), Gaps = 59/346 (17%)

Query: 343  RNRRQMEVISLRLKLQKLQEDAVENDDYD-----KAETLQQRLEDL------EQEKISLH 391
            R + Q+E ++   K++KL+++ +  DD +     + + L++R+ DL      E+EK    
Sbjct: 973  RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL 1032

Query: 392  FQLPSRQPALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVS 451
             +L ++  ++ S       +++  L++        + +   L    R LE  A D     
Sbjct: 1033 TKLKNKHESMIS-------ELEVRLKK-------EEKSRQELEKLKRKLEGDASDFHEQI 1078

Query: 452  ITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQL 511
               +  + + K QL K+ E LQA +        +L  EI ++   L+     +  L G +
Sbjct: 1079 ADLQAQIAELKMQLAKKEEELQAAL-------ARLDDEIAQKNNALK----KIRELEGHI 1127

Query: 512  SLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFC 571
            S          LQ+ L S       AE  +  R L E +++L   L++        ++  
Sbjct: 1128 S---------DLQEDLDSERAARNKAEKQK--RDLGEELEALKTELEDTLDSTATQQELR 1176

Query: 572  S------TLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLE--- 622
            +      T+ KK  D ET+     EA++  +   H    ++LTE++      +  L+   
Sbjct: 1177 AKREQEVTVLKKALDEETRSH---EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNK 1233

Query: 623  GLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAYGYKYCDAE 668
              L K     +  ++ LG  K++    ++++E Q      K  D E
Sbjct: 1234 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGE 1279



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 66/330 (20%), Positives = 130/330 (39%), Gaps = 34/330 (10%)

Query: 343  RNRRQMEVISLRLKLQKLQEDAVENDDYDKAET-LQQRLEDLEQEKISLHFQLPSRQPAL 401
            + R Q E+ +L    Q+ +E A   D  +K +  LQQ L+DL  + +    QL S     
Sbjct: 1401 KKRFQKEIENLT---QQYEEKAAAYDKLEKTKNRLQQELDDLVVD-LDNQRQLVSNLEKK 1456

Query: 402  SSFLGHLAAQVQAALRRGATQ----QASGDDTHTPLRMEPRLLEPTAQDSLHVSITRR-- 455
                  L A+ +    + A +    +A   +  T      R LE   +    +  T +  
Sbjct: 1457 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1516

Query: 456  ----DWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQ-WQGCDLTPLVGQ 510
                + L+  K  + K +  L+     LE + ++++ ++EE E +LQ  +   L   V  
Sbjct: 1517 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNM 1576

Query: 511  LSL-GQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEK 569
             +L GQ +   +A  +            +  E  R LQ ++      L++   +  ++  
Sbjct: 1577 QALKGQFERDLQARDE------------QNEEKRRQLQRQLHEYETELEDERKQRALAAA 1624

Query: 570  FCSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLL 629
                L   + D+E Q  + ++ +  AI        + L  +++    E E       ++ 
Sbjct: 1625 AKKKLEGDLKDLELQADSAIKGREEAIK-----QLRKLQAQMKDFQRELEDARASRDEIF 1679

Query: 630  VLSSRNVKKLGSVKEDYNRLRREVEHQETA 659
              +  N KK  S++ D  +L+ ++   E A
Sbjct: 1680 ATAKENEKKAKSLEADLMQLQEDLAAAERA 1709



 Score = 35.4 bits (80), Expect = 0.17
 Identities = 50/264 (18%), Positives = 108/264 (40%), Gaps = 40/264 (15%)

Query: 427  DDTHTPLRMEPRLLEPTAQDSLHVSITRRDW---LLQEKQQLQKEIEALQARMFVLEAKD 483
            +  H+ L  E  LL+   Q    +     +    L  +KQ+L++ +  ++AR+   E + 
Sbjct: 886  EQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRG 945

Query: 484  QQLRRE----------IEEQ--EQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAG 531
            QQL+ E          +EEQ  E++   Q   L  +  +  + +L++    + D      
Sbjct: 946  QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ----- 1000

Query: 532  QIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLP----- 586
                + +  +  + L+ERI  L  +L E   K     K  +     ++++E +L      
Sbjct: 1001 ----NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1056

Query: 587  ----ALLEAKMHAISGNHFWTAKDLTEEI----RSLTSEREGLEGLLSKL---LVLSSRN 635
                  L+ K+   + +      DL  +I      L  + E L+  L++L   +   +  
Sbjct: 1057 RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNA 1116

Query: 636  VKKLGSVKEDYNRLRREVEHQETA 659
            +KK+  ++   + L+ +++ +  A
Sbjct: 1117 LKKIRELEGHISDLQEDLDSERAA 1140



 Score = 33.1 bits (74), Expect = 0.86
 Identities = 64/277 (23%), Positives = 114/277 (41%), Gaps = 53/277 (19%)

Query: 338  RDCLLRNRRQMEVISLRLKLQK-LQEDAVENDDYDKAETL----QQRLE-DLEQEKISLH 391
            RD   R+ +  E    R +LQ+ L E   E +D  K   L    +++LE DL+  ++   
Sbjct: 1585 RDLQARDEQNEEK---RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1641

Query: 392  FQLPSRQPALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLR--------MEPRLLEPT 443
              +  R+ A+   L  L AQ++   R     +AS D+     +        +E  L++  
Sbjct: 1642 SAIKGREEAIKQ-LRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ-- 1698

Query: 444  AQDSLHVSITRRDWLLQEKQQLQKEI-------EALQARMFVLEAKDQQLRREIEEQEQQ 496
             Q+ L  +   R     EK++L +E+        ALQ     LEA+  QL  E+EE++  
Sbjct: 1699 LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1758

Query: 497  LQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLS 556
            ++                    V KA Q     + ++       +   S +++++  N  
Sbjct: 1759 ME---------------AMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN-- 1801

Query: 557  LKEITTKV-----CMSEKFCST---LRKKVNDIETQL 585
             KE+ +K+      +  KF ST   L  K+  +E Q+
Sbjct: 1802 -KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQV 1837


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 76/324 (23%), Positives = 126/324 (38%), Gaps = 52/324 (16%)

Query: 342  LRNRRQMEVISLRLKLQ---KLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQ 398
            LR +R+ EV  L+  L    +  E  V+      A+ +++  E LEQ K +    L   +
Sbjct: 1175 LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA-KANLDKNK 1233

Query: 399  PALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWL 458
              L      LA +++         QA  +  H   ++E ++ E   Q         R  L
Sbjct: 1234 QTLEKENADLAGELRVL------GQAKQEVEHKKKKLEAQVQE--LQSKCSDGERARAEL 1285

Query: 459  LQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQ-----WQGCDLTPLVGQLSL 513
              +  +LQ E+E++   +   E K  +L +++     QLQ      Q      L     L
Sbjct: 1286 NDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKL 1345

Query: 514  GQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCST 573
             QL+E   +LQD L          E  E  ++L+  I +LN+ L              S 
Sbjct: 1346 RQLEEERNSLQDQL---------DEEMEAKQNLERHISTLNIQL--------------SD 1382

Query: 574  LRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSS 633
             +KK+ D  + + AL E K            K   +EI +LT + E       KL    +
Sbjct: 1383 SKKKLQDFASTVEALEEGK------------KRFQKEIENLTQQYEEKAAAYDKLEKTKN 1430

Query: 634  RNVKKLGSVKEDYNRLRREVEHQE 657
            R  ++L  +  D +  R+ V + E
Sbjct: 1431 RLQQELDDLVVDLDNQRQLVSNLE 1454



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 73/346 (21%), Positives = 143/346 (41%), Gaps = 59/346 (17%)

Query: 343  RNRRQMEVISLRLKLQKLQEDAVENDDYD-----KAETLQQRLEDL------EQEKISLH 391
            R + Q+E ++   K++KL+++ +  DD +     + + L++R+ DL      E+EK    
Sbjct: 973  RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL 1032

Query: 392  FQLPSRQPALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVS 451
             +L ++  ++ S       +++  L++        + +   L    R LE  A D     
Sbjct: 1033 TKLKNKHESMIS-------ELEVRLKK-------EEKSRQELEKLKRKLEGDASDFHEQI 1078

Query: 452  ITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQL 511
               +  + + K QL K+ E LQA +        +L  EI ++   L+     +  L G +
Sbjct: 1079 ADLQAQIAELKMQLAKKEEELQAAL-------ARLDDEIAQKNNALK----KIRELEGHI 1127

Query: 512  SLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFC 571
            S          LQ+ L S       AE  +  R L E +++L   L++        ++  
Sbjct: 1128 S---------DLQEDLDSERAARNKAEKQK--RDLGEELEALKTELEDTLDSTATQQELR 1176

Query: 572  S------TLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLE--- 622
            +      T+ KK  D ET+     EA++  +   H    ++LTE++      +  L+   
Sbjct: 1177 AKREQEVTVLKKALDEETRSH---EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNK 1233

Query: 623  GLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAYGYKYCDAE 668
              L K     +  ++ LG  K++    ++++E Q      K  D E
Sbjct: 1234 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGE 1279



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 66/330 (20%), Positives = 130/330 (39%), Gaps = 34/330 (10%)

Query: 343  RNRRQMEVISLRLKLQKLQEDAVENDDYDKAET-LQQRLEDLEQEKISLHFQLPSRQPAL 401
            + R Q E+ +L    Q+ +E A   D  +K +  LQQ L+DL  + +    QL S     
Sbjct: 1401 KKRFQKEIENLT---QQYEEKAAAYDKLEKTKNRLQQELDDLVVD-LDNQRQLVSNLEKK 1456

Query: 402  SSFLGHLAAQVQAALRRGATQ----QASGDDTHTPLRMEPRLLEPTAQDSLHVSITRR-- 455
                  L A+ +    + A +    +A   +  T      R LE   +    +  T +  
Sbjct: 1457 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1516

Query: 456  ----DWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQ-WQGCDLTPLVGQ 510
                + L+  K  + K +  L+     LE + ++++ ++EE E +LQ  +   L   V  
Sbjct: 1517 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNM 1576

Query: 511  LSL-GQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEK 569
             +L GQ +   +A  +            +  E  R LQ ++      L++   +  ++  
Sbjct: 1577 QALKGQFERDLQARDE------------QNEEKRRQLQRQLHEYETELEDERKQRALAAA 1624

Query: 570  FCSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLL 629
                L   + D+E Q  + ++ +  AI        + L  +++    E E       ++ 
Sbjct: 1625 AKKKLEGDLKDLELQADSAIKGREEAIK-----QLRKLQAQMKDFQRELEDARASRDEIF 1679

Query: 630  VLSSRNVKKLGSVKEDYNRLRREVEHQETA 659
              +  N KK  S++ D  +L+ ++   E A
Sbjct: 1680 ATAKENEKKAKSLEADLMQLQEDLAAAERA 1709



 Score = 35.4 bits (80), Expect = 0.17
 Identities = 50/264 (18%), Positives = 108/264 (40%), Gaps = 40/264 (15%)

Query: 427  DDTHTPLRMEPRLLEPTAQDSLHVSITRRDW---LLQEKQQLQKEIEALQARMFVLEAKD 483
            +  H+ L  E  LL+   Q    +     +    L  +KQ+L++ +  ++AR+   E + 
Sbjct: 886  EQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRG 945

Query: 484  QQLRRE----------IEEQ--EQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAG 531
            QQL+ E          +EEQ  E++   Q   L  +  +  + +L++    + D      
Sbjct: 946  QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ----- 1000

Query: 532  QIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLP----- 586
                + +  +  + L+ERI  L  +L E   K     K  +     ++++E +L      
Sbjct: 1001 ----NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1056

Query: 587  ----ALLEAKMHAISGNHFWTAKDLTEEI----RSLTSEREGLEGLLSKL---LVLSSRN 635
                  L+ K+   + +      DL  +I      L  + E L+  L++L   +   +  
Sbjct: 1057 RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNA 1116

Query: 636  VKKLGSVKEDYNRLRREVEHQETA 659
            +KK+  ++   + L+ +++ +  A
Sbjct: 1117 LKKIRELEGHISDLQEDLDSERAA 1140



 Score = 33.1 bits (74), Expect = 0.86
 Identities = 64/277 (23%), Positives = 114/277 (41%), Gaps = 53/277 (19%)

Query: 338  RDCLLRNRRQMEVISLRLKLQK-LQEDAVENDDYDKAETL----QQRLE-DLEQEKISLH 391
            RD   R+ +  E    R +LQ+ L E   E +D  K   L    +++LE DL+  ++   
Sbjct: 1585 RDLQARDEQNEEK---RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1641

Query: 392  FQLPSRQPALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLR--------MEPRLLEPT 443
              +  R+ A+   L  L AQ++   R     +AS D+     +        +E  L++  
Sbjct: 1642 SAIKGREEAIKQ-LRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ-- 1698

Query: 444  AQDSLHVSITRRDWLLQEKQQLQKEI-------EALQARMFVLEAKDQQLRREIEEQEQQ 496
             Q+ L  +   R     EK++L +E+        ALQ     LEA+  QL  E+EE++  
Sbjct: 1699 LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1758

Query: 497  LQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLS 556
            ++                    V KA Q     + ++       +   S +++++  N  
Sbjct: 1759 ME---------------AMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN-- 1801

Query: 557  LKEITTKV-----CMSEKFCST---LRKKVNDIETQL 585
             KE+ +K+      +  KF ST   L  K+  +E Q+
Sbjct: 1802 -KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQV 1837


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 76/324 (23%), Positives = 126/324 (38%), Gaps = 52/324 (16%)

Query: 342  LRNRRQMEVISLRLKLQ---KLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQ 398
            LR +R+ EV  L+  L    +  E  V+      A+ +++  E LEQ K +    L   +
Sbjct: 1168 LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA-KANLDKNK 1226

Query: 399  PALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWL 458
              L      LA +++         QA  +  H   ++E ++ E   Q         R  L
Sbjct: 1227 QTLEKENADLAGELRVL------GQAKQEVEHKKKKLEAQVQE--LQSKCSDGERARAEL 1278

Query: 459  LQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQ-----WQGCDLTPLVGQLSL 513
              +  +LQ E+E++   +   E K  +L +++     QLQ      Q      L     L
Sbjct: 1279 NDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKL 1338

Query: 514  GQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCST 573
             QL+E   +LQD L          E  E  ++L+  I +LN+ L              S 
Sbjct: 1339 RQLEEERNSLQDQL---------DEEMEAKQNLERHISTLNIQL--------------SD 1375

Query: 574  LRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSS 633
             +KK+ D  + + AL E K            K   +EI +LT + E       KL    +
Sbjct: 1376 SKKKLQDFASTVEALEEGK------------KRFQKEIENLTQQYEEKAAAYDKLEKTKN 1423

Query: 634  RNVKKLGSVKEDYNRLRREVEHQE 657
            R  ++L  +  D +  R+ V + E
Sbjct: 1424 RLQQELDDLVVDLDNQRQLVSNLE 1447



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 73/346 (21%), Positives = 143/346 (41%), Gaps = 59/346 (17%)

Query: 343  RNRRQMEVISLRLKLQKLQEDAVENDDYD-----KAETLQQRLEDL------EQEKISLH 391
            R + Q+E ++   K++KL+++ +  DD +     + + L++R+ DL      E+EK    
Sbjct: 966  RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL 1025

Query: 392  FQLPSRQPALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVS 451
             +L ++  ++ S       +++  L++        + +   L    R LE  A D     
Sbjct: 1026 TKLKNKHESMIS-------ELEVRLKK-------EEKSRQELEKLKRKLEGDASDFHEQI 1071

Query: 452  ITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQL 511
               +  + + K QL K+ E LQA +        +L  EI ++   L+     +  L G +
Sbjct: 1072 ADLQAQIAELKMQLAKKEEELQAAL-------ARLDDEIAQKNNALK----KIRELEGHI 1120

Query: 512  SLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFC 571
            S          LQ+ L S       AE  +  R L E +++L   L++        ++  
Sbjct: 1121 S---------DLQEDLDSERAARNKAEKQK--RDLGEELEALKTELEDTLDSTATQQELR 1169

Query: 572  S------TLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLE--- 622
            +      T+ KK  D ET+     EA++  +   H    ++LTE++      +  L+   
Sbjct: 1170 AKREQEVTVLKKALDEETRSH---EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNK 1226

Query: 623  GLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAYGYKYCDAE 668
              L K     +  ++ LG  K++    ++++E Q      K  D E
Sbjct: 1227 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGE 1272



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 66/330 (20%), Positives = 130/330 (39%), Gaps = 34/330 (10%)

Query: 343  RNRRQMEVISLRLKLQKLQEDAVENDDYDKAET-LQQRLEDLEQEKISLHFQLPSRQPAL 401
            + R Q E+ +L    Q+ +E A   D  +K +  LQQ L+DL  + +    QL S     
Sbjct: 1394 KKRFQKEIENLT---QQYEEKAAAYDKLEKTKNRLQQELDDLVVD-LDNQRQLVSNLEKK 1449

Query: 402  SSFLGHLAAQVQAALRRGATQ----QASGDDTHTPLRMEPRLLEPTAQDSLHVSITRR-- 455
                  L A+ +    + A +    +A   +  T      R LE   +    +  T +  
Sbjct: 1450 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1509

Query: 456  ----DWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQ-WQGCDLTPLVGQ 510
                + L+  K  + K +  L+     LE + ++++ ++EE E +LQ  +   L   V  
Sbjct: 1510 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNM 1569

Query: 511  LSL-GQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEK 569
             +L GQ +   +A  +            +  E  R LQ ++      L++   +  ++  
Sbjct: 1570 QALKGQFERDLQARDE------------QNEEKRRQLQRQLHEYETELEDERKQRALAAA 1617

Query: 570  FCSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLL 629
                L   + D+E Q  + ++ +  AI        + L  +++    E E       ++ 
Sbjct: 1618 AKKKLEGDLKDLELQADSAIKGREEAIK-----QLRKLQAQMKDFQRELEDARASRDEIF 1672

Query: 630  VLSSRNVKKLGSVKEDYNRLRREVEHQETA 659
              +  N KK  S++ D  +L+ ++   E A
Sbjct: 1673 ATAKENEKKAKSLEADLMQLQEDLAAAERA 1702



 Score = 35.4 bits (80), Expect = 0.17
 Identities = 50/264 (18%), Positives = 108/264 (40%), Gaps = 40/264 (15%)

Query: 427  DDTHTPLRMEPRLLEPTAQDSLHVSITRRDW---LLQEKQQLQKEIEALQARMFVLEAKD 483
            +  H+ L  E  LL+   Q    +     +    L  +KQ+L++ +  ++AR+   E + 
Sbjct: 879  EQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRG 938

Query: 484  QQLRRE----------IEEQ--EQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAG 531
            QQL+ E          +EEQ  E++   Q   L  +  +  + +L++    + D      
Sbjct: 939  QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ----- 993

Query: 532  QIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLP----- 586
                + +  +  + L+ERI  L  +L E   K     K  +     ++++E +L      
Sbjct: 994  ----NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1049

Query: 587  ----ALLEAKMHAISGNHFWTAKDLTEEI----RSLTSEREGLEGLLSKL---LVLSSRN 635
                  L+ K+   + +      DL  +I      L  + E L+  L++L   +   +  
Sbjct: 1050 RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNA 1109

Query: 636  VKKLGSVKEDYNRLRREVEHQETA 659
            +KK+  ++   + L+ +++ +  A
Sbjct: 1110 LKKIRELEGHISDLQEDLDSERAA 1133



 Score = 33.1 bits (74), Expect = 0.86
 Identities = 64/277 (23%), Positives = 114/277 (41%), Gaps = 53/277 (19%)

Query: 338  RDCLLRNRRQMEVISLRLKLQK-LQEDAVENDDYDKAETL----QQRLE-DLEQEKISLH 391
            RD   R+ +  E    R +LQ+ L E   E +D  K   L    +++LE DL+  ++   
Sbjct: 1578 RDLQARDEQNEEK---RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1634

Query: 392  FQLPSRQPALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLR--------MEPRLLEPT 443
              +  R+ A+   L  L AQ++   R     +AS D+     +        +E  L++  
Sbjct: 1635 SAIKGREEAIKQ-LRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ-- 1691

Query: 444  AQDSLHVSITRRDWLLQEKQQLQKEI-------EALQARMFVLEAKDQQLRREIEEQEQQ 496
             Q+ L  +   R     EK++L +E+        ALQ     LEA+  QL  E+EE++  
Sbjct: 1692 LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1751

Query: 497  LQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLS 556
            ++                    V KA Q     + ++       +   S +++++  N  
Sbjct: 1752 ME---------------AMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN-- 1794

Query: 557  LKEITTKV-----CMSEKFCST---LRKKVNDIETQL 585
             KE+ +K+      +  KF ST   L  K+  +E Q+
Sbjct: 1795 -KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQV 1830


>gi|63252898 tropomyosin 1 alpha chain isoform 1 [Homo sapiens]
          Length = 284

 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 65/290 (22%), Positives = 119/290 (41%), Gaps = 37/290 (12%)

Query: 348 MEVISLRLKLQKLQE----DAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSS 403
           M+ I  ++++ KL +    D  E  + DK +  + R + LE E +SL  +L   +  L  
Sbjct: 1   MDAIKKKMQMLKLDKENALDRAEQAEADK-KAAEDRSKQLEDELVSLQKKLKGTEDELDK 59

Query: 404 FLGHLA-AQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEK 462
           +   L  AQ +  L       A  D      R++        ++ L  +  R    LQ+ 
Sbjct: 60  YSEALKDAQEKLELAEKKATDAEADVASLNRRIQ------LVEEELDRAQERLATALQKL 113

Query: 463 QQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQW----------------------- 499
           ++ +K  +  +  M V+E++ Q+   ++E QE QL+                        
Sbjct: 114 EEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIE 173

Query: 500 QGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEP-PETIRSLQERIKSLNLSLK 558
              +      +LS G+  E+ + L+    +   +   AE   +     +E IK L+  LK
Sbjct: 174 SDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLK 233

Query: 559 EITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLT 608
           E  T+   +E+  + L K ++D+E +L A  + K  AIS        D+T
Sbjct: 234 EAETRAEFAERSVTKLEKSIDDLEDELYA-QKLKYKAISEELDHALNDMT 282


>gi|156104874 envoplakin [Homo sapiens]
          Length = 2033

 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 77/355 (21%), Positives = 153/355 (43%), Gaps = 40/355 (11%)

Query: 341  LLRNRRQMEVISL--RLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQ 398
            ++R+ R  EV+    RLK Q  +         ++   LQ   ++  +E+  +  +  S++
Sbjct: 1257 VVRHERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVETKTVSKE 1316

Query: 399  PALSS---FLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSL----HVS 451
                     L   A +++  +R  A ++ + +D    L+ +  LLE    +       V 
Sbjct: 1317 VVRHEKDPVLEKEAERLRQEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVV 1376

Query: 452  ITRRDWLLQEKQ-QLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQ 510
            +T++D  L+E+  +L   ++    R   LE + QQLR  +EEQE  L +Q      L  +
Sbjct: 1377 VTQKDPKLREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVE 1436

Query: 511  LSLGQL----QEVSK---ALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTK 563
              L QL    QE+ K    +Q+ +     +    +P      L++  ++L   L +  T+
Sbjct: 1437 RELRQLTLRIQELEKRPPTVQEKIIMEEVVKLEKDP-----DLEKSTEALRWDLDQEKTQ 1491

Query: 564  VCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEG 623
            V       + L ++  +++ Q+  L +AK            K + +E+  +  +R  LE 
Sbjct: 1492 V-------TELNRECKNLQVQIDVLQKAKSQ---------EKTIYKEVIRVQKDRV-LED 1534

Query: 624  LLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAYGYKYCDAESWTQRSQQLA 678
              +++  + +R      + +E+  RLR  ++  ET  G  +   ES  QR++  A
Sbjct: 1535 ERARVWEMLNRERTARQAREEEARRLRERIDRAET-LGRTWSREESELQRARDQA 1588



 Score = 34.3 bits (77), Expect = 0.39
 Identities = 69/332 (20%), Positives = 137/332 (41%), Gaps = 50/332 (15%)

Query: 334  EPVLRDCLLRNRRQMEVISLRLKLQ-KLQEDAVENDDYDKAET-LQQRLEDLEQ------ 385
            E V+   +++  + +E++     L+ +++EDA      ++A   LQ R+EDLE+      
Sbjct: 1072 EKVVVKEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAEEAVAKLQARIEDLERAISSVE 1131

Query: 386  -EKISLHFQLPSRQPALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLR-MEPRLLEPT 443
             + I    +   + P L      L + ++    + AT      D H+    +E +  +  
Sbjct: 1132 PKVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELSDLHSKYSVVEKQRPKVQ 1191

Query: 444  AQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCD 503
             Q+ +H        + Q   + ++EI  L+A++  +  K   + +E+E+          D
Sbjct: 1192 LQERVHE-------IFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLLP-------D 1237

Query: 504  LTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTK 563
            L  L  Q    + +EV++          ++  H   PE +R + +R+K+    L E+   
Sbjct: 1238 LEVLRAQKPTVEYKEVTQ----------EVVRHERSPEVLREI-DRLKA---QLNELVNS 1283

Query: 564  VCMSEKFCSTL-------RKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTS 616
               S++    L       R++   +ET+  +  E   H         A+ L +E+R    
Sbjct: 1284 HGRSQEQLIRLQGERDEWRRERAKVETKTVS-KEVVRHEKDPVLEKEAERLRQEVREAAQ 1342

Query: 617  EREGLEG----LLSKLLVLSSRNVKKLGSVKE 644
            +R   E     L SK L+L  R  ++   V+E
Sbjct: 1343 KRRAAEDAVYELQSKRLLLERRKPEEKVVVQE 1374


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 58/208 (27%), Positives = 93/208 (44%), Gaps = 33/208 (15%)

Query: 462  KQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSK 521
            K++ QK  + L        AK +  R+E+EE+   L  +  DL     QL   Q+Q  S+
Sbjct: 854  KEEFQKTKDEL--------AKSEAKRKELEEKLVTLVQEKNDL-----QL---QVQAESE 897

Query: 522  ALQDTLASAGQI---PFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKV 578
             L D      Q+    F  E    I+ + ER +       E+T K    E  CS L+K +
Sbjct: 898  NLLDAEERCDQLIKAKFQLEAK--IKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI 955

Query: 579  NDIETQLPALLEAKMHAISGNHFWTAKDLTEE-------IRSLTSEREGLEGLLSKLLVL 631
            +D+E  L A +E + HA         K+LTEE       I  LT E++ L+    + L  
Sbjct: 956  DDLELTL-AKVEKEKHATENK----VKNLTEELSGLDETIAKLTREKKALQEAHQQALDD 1010

Query: 632  SSRNVKKLGSVKEDYNRLRREVEHQETA 659
                  K+ S+ +  ++L ++VE  E++
Sbjct: 1011 LQAEEDKVNSLNKTKSKLEQQVEDLESS 1038



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 72/329 (21%), Positives = 148/329 (44%), Gaps = 38/329 (11%)

Query: 361  QEDAVENDDYDKAETLQQRLEDLE----QEKISLHFQLPSRQPALSSFLGHLAAQVQAAL 416
            +ED V + +  K++ L+Q++EDLE    QEK  L   L   +  L   L  LA +    L
Sbjct: 1014 EEDKVNSLNKTKSK-LEQQVEDLESSLEQEK-KLRVDLERNKRKLEGDL-KLAQESILDL 1070

Query: 417  RRGATQQASGDDTHTPLRMEPRLLEPTAQD--SLHVSITRRDWLLQEK-QQLQKEIEALQ 473
                 Q    D+       E   L+   +D  +L +   ++   LQ + ++L++EIEA +
Sbjct: 1071 ENDKQQL---DERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAER 1127

Query: 474  ARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQD----TLAS 529
            A     E +     RE+EE  ++L+  G  +T    +L+  +  E  K  +D    TL  
Sbjct: 1128 ATRAKTEKQRSDYARELEELSERLEEAG-GVTSTQIELNKKREAEFLKLRRDLEEATLQH 1186

Query: 530  AGQI-PFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPAL 588
               +     +  +++  L E+I +L    +++       EK  S  + +++D+ + + ++
Sbjct: 1187 EAMVAALRKKHADSVAELGEQIDNLQRVKQKL-------EKEKSEFKLEIDDLSSSMESV 1239

Query: 589  LEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNR 648
             ++K      N     + L +++     + E ++  LS+L    SR       ++ +   
Sbjct: 1240 SKSK-----ANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSR-------LQTEAGE 1287

Query: 649  LRREVEHQETAYGYKYCDAESWTQRSQQL 677
            L R++E +E+         +++TQ++++L
Sbjct: 1288 LSRQLEEKESIVSQLSRSKQAFTQQTEEL 1316


>gi|32698688 citron [Homo sapiens]
          Length = 2027

 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 74/354 (20%), Positives = 147/354 (41%), Gaps = 47/354 (13%)

Query: 359  KLQEDAVENDDYDKA--ETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQVQAAL 416
            K+ ++ ++ D  DK   E + QR E+   EK  +  +  +   A+ S +  L  ++    
Sbjct: 726  KVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELS 785

Query: 417  RRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEAL---- 472
                    S   T   ++ +  ++    Q   ++  T+   L  + ++L++++E +    
Sbjct: 786  EANKLAANSSLFTQRNMKAQEEMISELRQQKFYLE-TQAGKLEAQNRKLEEQLEKISHQD 844

Query: 473  ---QARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLAS 529
               + R+  LE + +++  E EEQ+ +L+ Q  +L     QLSL + +    ALQ   A+
Sbjct: 845  HSDKNRLLELETRLREVSLEHEEQKLELKRQLTEL-----QLSLQERESQLTALQAARAA 899

Query: 530  AGQIPFHA--EPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPA 587
                   A  E  ET    +E I++L     EI  K       C+     + D+E QL  
Sbjct: 900  LESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTV----ITDLEEQLNQ 955

Query: 588  LLEAKMHAISGNHFWTAKDLTE---------EIRS---------------LTSEREGLEG 623
            L E     ++  +F+ +K L E         ++RS               LTS+++ +E 
Sbjct: 956  LTEDNAE-LNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEA 1014

Query: 624  LLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAYGYKYCDAESWTQRSQQL 677
            L +   +L  + V  L ++ ++     R+ E   +  G +    E   +  Q++
Sbjct: 1015 LKTTCTMLEEQ-VMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRM 1067



 Score = 30.4 bits (67), Expect = 5.6
 Identities = 48/177 (27%), Positives = 68/177 (38%), Gaps = 32/177 (18%)

Query: 356  KLQKLQEDAVENDDYDKAETLQ--QRLEDL----EQEKISLHFQLPSRQPALSSFLGHLA 409
            KL++  E     D  DK   L+   RL ++    E++K+ L  QL   Q +L      L 
Sbjct: 832  KLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLT 891

Query: 410  A-QVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQ--------DSLHVSITRRDWLLQ 460
            A Q   A      +QA  +   T    E  +   TA         D+L  S T    L +
Sbjct: 892  ALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEE 951

Query: 461  EKQQLQKEIEALQARMFVLE--------AKDQ---------QLRREIEEQEQQLQWQ 500
            +  QL ++   L  + F L         A D+          LRREI E+E QL  Q
Sbjct: 952  QLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQ 1008


>gi|46592991 GRIP1 associated protein 1 isoform 1 [Homo sapiens]
          Length = 841

 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 84/358 (23%), Positives = 141/358 (39%), Gaps = 47/358 (13%)

Query: 344 NRRQMEVISLRLKLQKLQE---------DAVENDDYDKAETLQQRLEDLEQEKISLHFQL 394
           +R Q E+  L  KL+K QE         + + ND  +K E LQQR E   + +++   +L
Sbjct: 222 SRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKL 281

Query: 395 PSRQPALSSFLGHLAAQVQ------AALRRGATQQASGDDTHTPLRMEPRLLEPTA---- 444
                A +  L  L  Q Q      AA  R    Q S        ++E  L E  A    
Sbjct: 282 QQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTS 341

Query: 445 -----------QDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQ 493
                         L++   +   L  E QQ Q E E L  +   L ++ Q+  R     
Sbjct: 342 LAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRL 401

Query: 494 EQQLQWQGCDLTPLVGQLSLGQLQ-EVSKALQDTLA--SAGQIPFHAEPPETIRSLQER- 549
            +QLQ  G +   L  +L   +   E  KA+ D LA  +  +   H E    +R   E+ 
Sbjct: 402 LEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKE 461

Query: 550 ----IKSLNLSLKEI-TTKVCMSEKFCSTLRK---KVNDIET--QLPALLEAKMHAISGN 599
                      L+E+   K    E+    +R+   +  ++ET  Q    L+A++H++ G 
Sbjct: 462 VLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGA 521

Query: 600 HFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQE 657
             W  + L E   SL  +++  E  L +      ++  +L   +E+   +R ++E  +
Sbjct: 522 KGWFERRLKEAEESLQQQQQEQEEALKQ---CREQHAAELKGKEEELQDVRDQLEQAQ 576



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 34/185 (18%), Positives = 72/185 (38%), Gaps = 9/185 (4%)

Query: 485 QLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQI---------PF 535
           +L+ E+E++E++L W+         Q    +LQE    L + L    +            
Sbjct: 193 ELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETL 252

Query: 536 HAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHA 595
             +    I  LQ+R ++ + +    T K+    +  +    ++ D          A + A
Sbjct: 253 FNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAAALRA 312

Query: 596 ISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEH 655
           +       + D  E++  L +E   L   L+ L  + +   ++L  ++E    L  E++ 
Sbjct: 313 LQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQ 372

Query: 656 QETAY 660
           Q+  Y
Sbjct: 373 QQAEY 377


>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
            sapiens]
          Length = 1939

 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 55/206 (26%), Positives = 91/206 (44%), Gaps = 25/206 (12%)

Query: 460  QEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEV 519
            +E   +++E E  +  +   EAK    R+E+EE+   L  +  DL     QL   Q+Q  
Sbjct: 851  KEMANMKEEFEKTKEELAKTEAK----RKELEEKMVTLMQEKNDL-----QL---QVQAE 898

Query: 520  SKALQDTLASAGQ-IPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKV 578
            + AL D      Q I    +    I+ + ER +       E+T K    E  CS L+K +
Sbjct: 899  ADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI 958

Query: 579  NDIETQLPALLEAKMHAISGNHFWTAKDLTEE-------IRSLTSEREGLEGLLSKLLVL 631
            +D+E  L A +E + HA         K+LTEE       I  LT E++ L+    + L  
Sbjct: 959  DDLELTL-AKVEKEKHATENK----VKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDD 1013

Query: 632  SSRNVKKLGSVKEDYNRLRREVEHQE 657
                  K+ ++ +   +L ++V+  E
Sbjct: 1014 LQMEEDKVNTLTKAKTKLEQQVDDLE 1039



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 58/321 (18%), Positives = 141/321 (43%), Gaps = 34/321 (10%)

Query: 371  DKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQVQAALR--RGATQQASGDD 428
            DK  TL +    LEQ+   L   L  ++  L   L     +++  L+  + +T     D 
Sbjct: 1019 DKVNTLTKAKTKLEQQVDDLEGSL-EQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDK 1077

Query: 429  THTPLRMEPRLLEPTA-------QDSLHVSITRRDWLLQEK-QQLQKEIEALQARMFVLE 480
                 +++ +  E +        + +L + + ++   LQ + ++L++EIEA +A     E
Sbjct: 1078 QQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAE 1137

Query: 481  AKDQQLRREIEEQEQQLQWQGCDLTPLV--GQLSLGQLQEVSKALQDTLA--SAGQIPFH 536
             +   L RE+EE  ++L+  G   +  +   +    + Q++ + L+++     A      
Sbjct: 1138 KQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALR 1197

Query: 537  AEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAI 596
             +  +++  L E+I SL    +++       EK  S L+ ++ND+ + +  + +AK    
Sbjct: 1198 KKHADSVAELGEQIDSLQRVKQKL-------EKEKSELKMEINDLASNMETVSKAK---- 1246

Query: 597  SGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQ 656
              N     + L +++  + ++ E  + L+++L    +R       +  +     R+++ +
Sbjct: 1247 -ANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKAR-------LHTESGEFSRQLDEK 1298

Query: 657  ETAYGYKYCDAESWTQRSQQL 677
            +          +++TQ+ ++L
Sbjct: 1299 DAMVSQLSRGKQAFTQQIEEL 1319



 Score = 30.0 bits (66), Expect = 7.3
 Identities = 36/199 (18%), Positives = 83/199 (41%), Gaps = 16/199 (8%)

Query: 458  LLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQ 517
            L Q  Q  ++ +EA+ ++   LE   Q+L+ E+E+    ++             +   L 
Sbjct: 1397 LAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNA---------ACIALD 1447

Query: 518  EVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKK 577
            +  +     LA   Q   + E    + + Q+  +SL+  L ++      S     TL+++
Sbjct: 1448 KKQRNFDKVLAEWKQ--KYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRE 1505

Query: 578  VNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVK 637
              +++ ++  L E    A  G H     +L +  + L  E+  L+  L +          
Sbjct: 1506 NKNLQQEISDLTE--QIAEGGKHI---HELEKVKKQLDHEKSELQTSLEEAEASLEHEEG 1560

Query: 638  KLGSVKEDYNRLRREVEHQ 656
            K+  ++ + N+++ E++ +
Sbjct: 1561 KILRIQLELNQVKSEIDRK 1579


>gi|157738667 FYVE and coiled-coil domain containing 1 [Homo
           sapiens]
          Length = 1478

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 74/308 (24%), Positives = 127/308 (41%), Gaps = 57/308 (18%)

Query: 329 LLRKWEPVLRDCLLRNRRQMEVISLRLKLQKLQEDAVEND-DYDKA-ETLQQRLEDLEQE 386
           L ++WE       +    Q  V  L+  LQ L+  A E + DY  A   L+  L+ L QE
Sbjct: 298 LQKQWE-------VTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQPLAQE 350

Query: 387 KISLHFQLPSRQPALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQD 446
             +    L  +   L+SF G LA   Q A     T+                  EP   D
Sbjct: 351 LEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQ---------------EPIPSD 395

Query: 447 SLHVSITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTP 506
           +            QE Q+L ++++AL+     +E  ++Q   ++E+  ++LQ +      
Sbjct: 396 A-----------AQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKE----- 439

Query: 507 LVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERI---KSLNLSLKEITTK 563
              + SL +L +    LQ+ L+  GQ     E  +  R LQE +    S    L E+  +
Sbjct: 440 -DARASLERLVKEMAPLQEELSGKGQ-----EADQLWRRLQELLAHTSSWEEELAELRRE 493

Query: 564 VCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLE- 622
               ++    L ++V  +  QL   LE ++  +S +      DL E+ + L  +++ L  
Sbjct: 494 KKQQQEEKELLEQEVRSLTRQL-QFLETQLAQVSQH----VSDLEEQKKQLIQDKDHLSQ 548

Query: 623 --GLLSKL 628
             G+L +L
Sbjct: 549 QVGMLERL 556



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 82/390 (21%), Positives = 147/390 (37%), Gaps = 113/390 (28%)

Query: 345  RRQMEVISLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSF 404
            R Q +V+ L+ K++         DD DK ++     E + +E  +L  QL  +  AL+  
Sbjct: 787  RLQAQVVDLQAKMRAAL------DDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNR- 839

Query: 405  LGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQ 464
              H+   +Q + R GA Q+   D                                 E QQ
Sbjct: 840  -AHVQELLQCSEREGALQEERAD---------------------------------EAQQ 865

Query: 465  LQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQL------------- 511
             ++E+ ALQ  +   +   ++ + E  E ++QL     D   L  Q+             
Sbjct: 866  REEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQVCALTVEKERVEEA 925

Query: 512  ------------------------SLGQLQEVSKALQDTL----ASAGQIP----FHAEP 539
                                     +  LQ+  ++LQ+ L    A+AG +P      A+ 
Sbjct: 926  LACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQA 985

Query: 540  PETIRSLQERIK--------SLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEA 591
             +  +SLQE            L+  + +  +++  + + C +LR ++ +   QL A  EA
Sbjct: 986  EQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEA 1045

Query: 592  --KMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRL 649
              K+ A       T  D+ E++ S TS        L++      R  K+  +++ED  R 
Sbjct: 1046 VEKLKA-------TQADMGEKL-SCTSNH------LAECQAAMLRKDKEGAALREDLERT 1091

Query: 650  RREVEHQET---AYGYKYCDAESWTQRSQQ 676
            ++E+E   T    Y  K C   +  +R+ Q
Sbjct: 1092 QKELEKATTKIQEYYNKLCQEVTNRERNDQ 1121



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 43/159 (27%), Positives = 70/159 (44%), Gaps = 31/159 (19%)

Query: 340  CLLRNRRQMEVISLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQP 399
            C L   ++    +L   +Q+LQ DA E    ++ E L++++  L+QEK SL  +L + + 
Sbjct: 913  CALTVEKERVEEALACAVQELQ-DAKEAASRER-EGLERQVAGLQQEKESLQEKLKAAKA 970

Query: 400  ALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLL 459
            A  S  G  A   QA  R  + Q+A+  + +T                            
Sbjct: 971  AAGSLPGLQAQLAQAEQRAQSLQEAAHQELNT---------------------------- 1002

Query: 460  QEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQ 498
              K QL  EI   Q+R+     + + LR ++EEQ +QLQ
Sbjct: 1003 -LKFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQ 1040



 Score = 35.0 bits (79), Expect = 0.23
 Identities = 68/351 (19%), Positives = 141/351 (40%), Gaps = 51/351 (14%)

Query: 359 KLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQ--VQAAL 416
           K +++ + +D   + + L ++L+ LE+E+  +      +   L   +  L  +   +A+L
Sbjct: 386 KGRQEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASL 445

Query: 417 RRGATQQA--------SGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQ--EKQQLQ 466
            R   + A         G +     R    LL  T+     ++  RR+   Q  EK+ L+
Sbjct: 446 ERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLE 505

Query: 467 KEIEALQARMFVLEAKDQQLRR---EIEEQEQQLQWQGCDLTPLVGQLS----------- 512
           +E+ +L  ++  LE +  Q+ +   ++EEQ++QL      L+  VG L            
Sbjct: 506 QEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELP 565

Query: 513 -LGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFC 571
             G+  E    +  +L  A       +P E  R LQE        L +   +    E+  
Sbjct: 566 VAGEKNEALVPVNSSLQEA-----WGKPEEEQRGLQE------AQLDDTKVQEGSQEE-- 612

Query: 572 STLRKKVNDIETQLP------ALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLL 625
             LR+   ++E +L        LLE K+ A+  ++    + L +   ++      LE   
Sbjct: 613 -ELRQANRELEKELQNVVGRNQLLEGKLQALQADY----QALQQRESAIQGSLASLEAEQ 667

Query: 626 SKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAYGYKYCDAESWTQRSQQ 676
           + +  L  +    L +V++    ++ ++  +E     K  + +   +  +Q
Sbjct: 668 ASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQ 718



 Score = 34.7 bits (78), Expect = 0.30
 Identities = 65/292 (22%), Positives = 114/292 (39%), Gaps = 61/292 (20%)

Query: 357 LQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQVQAAL 416
           LQ+ Q D  +  +  + E L+Q   +LE+E  ++      R   L   L  L A  QA  
Sbjct: 595 LQEAQLDDTKVQEGSQEEELRQANRELEKELQNV----VGRNQLLEGKLQALQADYQALQ 650

Query: 417 RRGATQQAS--------GDDTHTPLRMEPRLLEPT-AQDSLHVSITRRDWLLQEKQQLQK 467
           +R +  Q S            H   +ME  LL    A++++   +  ++ +LQ K     
Sbjct: 651 QRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSK----- 705

Query: 468 EIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTL 527
                       E + QQLR E+E+ +Q  + +  +L  L       Q Q+ ++ ++   
Sbjct: 706 ------------EGECQQLREEVEQCQQLAEARHRELRALE-----SQCQQQTQLIEVLT 748

Query: 528 ASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPA 587
           A  GQ       P T    +E    L LS  ++     + +     L+ +V D++ ++ A
Sbjct: 749 AEKGQ---QGVGPPTDNEARELAAQLALSQAQLE----VHQGEVQRLQAQVVDLQAKMRA 801

Query: 588 LLE---------AKMHAISGNHFWTAKDLTEEIRSLT----------SEREG 620
            L+         +   A+   H    + L E+  +L           SEREG
Sbjct: 802 ALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREG 853



 Score = 33.1 bits (74), Expect = 0.86
 Identities = 55/249 (22%), Positives = 102/249 (40%), Gaps = 32/249 (12%)

Query: 456 DWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQ----------GCDLT 505
           D +  E  QL+   + L+ RM  L+ ++Q+LR  + +Q +QLQ +             LT
Sbjct: 233 DEMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLT 292

Query: 506 PLVGQLSLGQLQEVSKALQDTL-------------ASAGQIPFHAEPPETIRSLQERIKS 552
            LV +L   +  EV++A Q+T+             A+  +  +H         LQ   + 
Sbjct: 293 CLVAELQ--KQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQPLAQE 350

Query: 553 LNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIR 612
           L  +   +  K      F   L       +T      + +   I  +     ++L E+++
Sbjct: 351 LEATRDSLDKKNQHLASFPGWLAMAQQKADTASDT--KGRQEPIPSDAAQEMQELGEKLQ 408

Query: 613 SLTSEREGLEGLLSKLLVLSSRNVKKLGSVKED----YNRLRREVEHQETAYGYKYCDAE 668
           +L  ER  +E +  +      + VK+L  +KED      RL +E+   +     K  +A+
Sbjct: 409 ALERERTKVEEVNRQQSAQLEQLVKEL-QLKEDARASLERLVKEMAPLQEELSGKGQEAD 467

Query: 669 SWTQRSQQL 677
              +R Q+L
Sbjct: 468 QLWRRLQEL 476


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 76/299 (25%), Positives = 131/299 (43%), Gaps = 34/299 (11%)

Query: 345 RRQMEVISLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSF 404
           R   +V SL  +L  L    ++  D + A   QQ      +EK +   Q   +Q   S  
Sbjct: 495 RLTAQVASLTSELTTLNA-TIQQQDQELAGLKQQA-----KEKQAQLAQTLQQQEQASQG 548

Query: 405 LGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQ 464
           L H   Q+ ++L++   Q     +     R +      TA +    S+  RD  L++ + 
Sbjct: 549 LRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEA 608

Query: 465 LQKE----IEALQARMFVL-EAKDQ------QLRREIEEQEQQL-QWQGCDLTPLVGQ-L 511
           L+KE    +E LQ ++ V  EA+D       Q +RE  E  +++ + Q C  T    Q  
Sbjct: 609 LEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHE 668

Query: 512 SLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFC 571
           +  Q+ E+   L+     A +    A+  +    LQE++++L  SLK   TK  + E+  
Sbjct: 669 AQAQVAELELQLRSEQQKATEKERVAQEKD---QLQEQLQALKESLK--VTKGSLEEE-- 721

Query: 572 STLRKKVNDIETQLPAL--LEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKL 628
              R+  + +E Q   +  L+A+  ++   H    K+L EE     + R+GLE  L +L
Sbjct: 722 --KRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEE----RAGRKGLEARLQQL 774



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 75/333 (22%), Positives = 133/333 (39%), Gaps = 30/333 (9%)

Query: 345  RRQMEVISLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSF 404
            ++Q +  SL   L+  +    E D     ETLQ +LE+  QE       L   Q AL+S 
Sbjct: 1138 KQQEQADSLERSLEAERASRAERDS--ALETLQGQLEEKAQE-------LGHSQSALAS- 1187

Query: 405  LGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQ 464
                 AQ + A  R   Q  S  +     ++     E   ++SL +S    +  +  +Q 
Sbjct: 1188 -----AQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSL-ISSLEEEVSILNRQV 1241

Query: 465  LQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQ 524
            L+KE E+ + +  V+   ++   +++EE+ + LQ +    +    + S    +EV    +
Sbjct: 1242 LEKEGESKELKRLVMAESEKS--QKLEERLRLLQAETASNSARAAERSSALREEVQSLRE 1299

Query: 525  DTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQ 584
            +   +  Q        + + S  ER + L   LK    K    E+  STL+ +    +  
Sbjct: 1300 E---AEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQAL 1356

Query: 585  LPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKE 644
            +  LL AK H         A         L   ++   GL ++LL    R  ++LG +  
Sbjct: 1357 VSELLPAK-HLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELL----RAQRELGELIP 1411

Query: 645  DYNRLRREVEHQETAYGYKYCDAESWTQRSQQL 677
                LR++V  QE        +  S+ ++   L
Sbjct: 1412 ----LRQKVAEQERTAQQLRAEKASYAEQLSML 1440



 Score = 38.5 bits (88), Expect = 0.021
 Identities = 60/273 (21%), Positives = 105/273 (38%), Gaps = 37/273 (13%)

Query: 371 DKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQVQAALRRGATQQASGDDTH 430
           +K E LQ +L  LE+    L    P  +      LG +  Q++   +  AT  A+    +
Sbjct: 378 EKNEILQGKLSQLEEHLSQLQDNPPQEK---GEVLGDVL-QLETLKQEAATLAAN----N 429

Query: 431 TPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREI 490
           T L+    +LE          +  R    +EKQQL   I  LQ+ +         L +  
Sbjct: 430 TQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSI-------SNLSQAK 482

Query: 491 EEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERI 550
           EE EQ  Q  G  LT  V  L+  +L  ++  +Q             +  + +  L+++ 
Sbjct: 483 EELEQASQAHGARLTAQVASLT-SELTTLNATIQ-------------QQDQELAGLKQQA 528

Query: 551 KSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEE 610
           K     L +   +    E+    LR +V  + + L    E ++  ++     T +D  ++
Sbjct: 529 KEKQAQLAQTLQQ---QEQASQGLRHQVEQLSSSLKQ-KEQQLKEVAEKQEATRQDHAQQ 584

Query: 611 IRSLTSEREG----LEGLLSKLLVLSSRNVKKL 639
           + +   ERE      +  L +L  L      KL
Sbjct: 585 LATAAEEREASLRERDAALKQLEALEKEKAAKL 617



 Score = 35.4 bits (80), Expect = 0.17
 Identities = 43/176 (24%), Positives = 78/176 (44%), Gaps = 15/176 (8%)

Query: 455 RDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLG 514
           ++WL +++ QL+KE+ A       LE K++ L+ ++ + E+ L  Q  D  P      LG
Sbjct: 353 QEWL-EKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLS-QLQDNPPQEKGEVLG 410

Query: 515 ---QLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFC 571
              QL+ + +      A+  Q+    E  ET R  QE          ++  +    E+  
Sbjct: 411 DVLQLETLKQEAATLAANNTQLQARVEMLETERGQQE---------AKLLAERGHFEEEK 461

Query: 572 STLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSK 627
             L   + D+++ +  L +AK      +    A+ LT ++ SLTSE   L   + +
Sbjct: 462 QQLSSLITDLQSSISNLSQAKEELEQASQAHGAR-LTAQVASLTSELTTLNATIQQ 516



 Score = 33.9 bits (76), Expect = 0.51
 Identities = 53/225 (23%), Positives = 94/225 (41%), Gaps = 14/225 (6%)

Query: 341  LLRNRRQMEVISLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPA 400
            +L  R++ +    +L  Q  Q +  + +   + E L ++L D +Q       +L + Q A
Sbjct: 1519 VLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQ-A 1577

Query: 401  LSSFLGHLAAQVQAALRRGATQQASGDDT--HTPLRMEPRLLEPTAQDSLHVSITRRDWL 458
                    A ++QA L     Q +  +    H  L+ME       A+   +  +  +   
Sbjct: 1578 QGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQ--- 1634

Query: 459  LQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLG--QL 516
            L+  +QLQKE + L+A    L  + QQ   + +E EQ  +     +  L  Q++    QL
Sbjct: 1635 LRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQL 1694

Query: 517  QEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEIT 561
            +++ K    T A        +  P+    L   I SL+LS +E T
Sbjct: 1695 RDLGKFQVATDA------LKSREPQAKPQLDLSIDSLDLSCEEGT 1733



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 69/306 (22%), Positives = 125/306 (40%), Gaps = 39/306 (12%)

Query: 337  LRDCLLRNRRQM-EVISLRLKLQKLQEDA----VENDDYDKAETLQQRLEDLEQEKISLH 391
            LR  LLR +R++ E+I LR K+ + +  A     E   Y +  ++ ++   L  E+    
Sbjct: 1395 LRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEE---- 1450

Query: 392  FQLPSRQPALSSFLGHLAAQVQAALRRGATQQ---ASGDDTHTPLRMEPRLLEPTAQDSL 448
                +R     + LG    +V+    R    Q   A   D  T L    R  + TA++ L
Sbjct: 1451 ----NRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARE-L 1505

Query: 449  HVSITRRDW----LLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEE---------QEQ 495
             V   + +     +L+E+Q+ Q+E + L A++  LE   ++  +++EE         Q  
Sbjct: 1506 EVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQAS 1565

Query: 496  QLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAE----PPETIRSLQERIK 551
            ++Q Q        G  S  + Q +   L +  A   Q    AE      E  ++  +  K
Sbjct: 1566 KVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKK 1625

Query: 552  SLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEI 611
              N  L+E    +   +K    LR +   +  +L    +A +         T + LT ++
Sbjct: 1626 QQNQELQEQLRSLEQLQKENKELRAEAERLGHELQ---QAGLKTKEAEQ--TCRHLTAQV 1680

Query: 612  RSLTSE 617
            RSL ++
Sbjct: 1681 RSLEAQ 1686



 Score = 31.2 bits (69), Expect = 3.3
 Identities = 74/353 (20%), Positives = 130/353 (36%), Gaps = 61/353 (17%)

Query: 343 RNRRQMEVISLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALS 402
           ++  Q +V  L L+L+  Q+ A E              E + QEK  L  QL + + +L 
Sbjct: 666 QHEAQAQVAELELQLRSEQQKATEK-------------ERVAQEKDQLQEQLQALKESLK 712

Query: 403 SFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEK 462
              G L  +     RR A          + L+ E R L                  +++ 
Sbjct: 713 VTKGSLEEEK----RRAADALEEQQRCISELKAETRSL------------------VEQH 750

Query: 463 QQLQKEIEALQARMFVLEAKDQQ-----------LRREIEEQEQQLQWQGCDLTPLVGQL 511
           ++ +KE+E  +A    LEA+ QQ           LRRE+ E          +   LV ++
Sbjct: 751 KRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEV 810

Query: 512 SLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFC 571
           +  +     +  +D+     Q  + A   E + +L+E  +     L+E   KV   E   
Sbjct: 811 AAWR-----ERYEDSQQEEAQ--YGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHS 863

Query: 572 STLRKKVNDIETQLPALLEAKMHAISGNHFWTAK------DLTEEIRSLTSEREGLEGLL 625
                +  +   +L A L   +  +        K       L E++ + + E   LE L+
Sbjct: 864 ELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLV 923

Query: 626 SKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAYGYKYCDAESWTQRSQQLA 678
            K         ++L  VKE      R+ E  E   G ++C  ++  Q  ++ A
Sbjct: 924 RKAGEQQETASREL--VKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREA 974


>gi|223555975 tropomyosin 4 isoform 1 [Homo sapiens]
          Length = 284

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 57/268 (21%), Positives = 110/268 (41%), Gaps = 38/268 (14%)

Query: 348 MEVISLRLKLQKL-QEDAVENDDYDKAE--TLQQRLEDLEQEKISLHFQLPSRQPALSSF 404
           ME I  ++++ KL +E+A++  +  +A+    + + + +E+E   L  +L   +  L  +
Sbjct: 1   MEAIKKKMQMLKLDKENAIDRAEQAEADKKAAEDKCKQVEEELTHLQKKLKGTEDELDKY 60

Query: 405 LGHLA-AQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQ 463
              L  AQ +  L       A GD      R++        ++ L  +  R    LQ+ +
Sbjct: 61  SEDLKDAQEKLELTEKKASDAEGDVAALNRRIQ------LVEEELDRAQERLATALQKLE 114

Query: 464 QLQKEIEALQARMFVLEAKDQQLRREIEEQEQQL-------------------------- 497
           + +K  +  +  M V+E +  +   ++E QE QL                          
Sbjct: 115 EAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADRKYEEVARKLVILEG 174

Query: 498 QWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSL 557
           + +  +    V +L  G L+E  K + + L S           E     +E IK L+  L
Sbjct: 175 ELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKED--KYEEEIKLLSDKL 232

Query: 558 KEITTKVCMSEKFCSTLRKKVNDIETQL 585
           KE  T+   +E+  + L K ++D+E +L
Sbjct: 233 KEAETRAEFAERTVAKLEKTIDDLEEKL 260


>gi|205277396 dynactin 1 isoform 4 [Homo sapiens]
          Length = 1139

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 74/340 (21%), Positives = 147/340 (43%), Gaps = 38/340 (11%)

Query: 300 GSSSSLDPSLAGCGGDGSSGSGDAHSWDTLLRKWEPVLRDCLLRNRRQM--------EVI 351
           G+SSSL PS +   G+ SS      +   L     P++   +L +   +        E  
Sbjct: 28  GASSSLGPSGSASAGELSSSEPSTPAQTPLAA---PIIPTPVLTSPGAVPPLPSPSKEEE 84

Query: 352 SLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQ 411
            LR +++ L+E  +E     +AE  + +L++LE+ KI L      +     S +    A 
Sbjct: 85  GLRAQVRDLEEK-LETLRLKRAED-KAKLKELEKHKIQLE-----QVQEWKSKMQEQQAD 137

Query: 412 VQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQ--DSLHVSITRRDWLLQEKQQLQKEI 469
           +Q  L+    +          L  + R +E  A   D++ ++   ++   +  + LQ+E+
Sbjct: 138 LQRRLKEARKEAKEA------LEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEV 191

Query: 470 EALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLAS 529
           EAL+ R+  L    + L+ EIEE       +G D         L QL+E +  L+D L  
Sbjct: 192 EALKERVDELTTDLEILKAEIEE-------KGSD--GAASSYQLKQLEEQNARLKDALVR 242

Query: 530 AGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALL 589
              +   +E  E ++ LQ+ ++  N  L+ +  +    ++  S     +++++ Q+ A L
Sbjct: 243 MRDLS-SSEKQEHVK-LQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAAL 300

Query: 590 EA-KMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKL 628
            A +M  +  +     ++   E+R    + E +  +  +L
Sbjct: 301 GAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDEL 340


>gi|205277392 dynactin 1 isoform 3 [Homo sapiens]
          Length = 1253

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 74/340 (21%), Positives = 147/340 (43%), Gaps = 38/340 (11%)

Query: 300 GSSSSLDPSLAGCGGDGSSGSGDAHSWDTLLRKWEPVLRDCLLRNRRQM--------EVI 351
           G+SSSL PS +   G+ SS      +   L     P++   +L +   +        E  
Sbjct: 142 GASSSLGPSGSASAGELSSSEPSTPAQTPLAA---PIIPTPVLTSPGAVPPLPSPSKEEE 198

Query: 352 SLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQ 411
            LR +++ L+E  +E     +AE  + +L++LE+ KI L      +     S +    A 
Sbjct: 199 GLRAQVRDLEEK-LETLRLKRAED-KAKLKELEKHKIQLE-----QVQEWKSKMQEQQAD 251

Query: 412 VQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQ--DSLHVSITRRDWLLQEKQQLQKEI 469
           +Q  L+    +          L  + R +E  A   D++ ++   ++   +  + LQ+E+
Sbjct: 252 LQRRLKEARKEAKEA------LEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEV 305

Query: 470 EALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLAS 529
           EAL+ R+  L    + L+ EIEE       +G D         L QL+E +  L+D L  
Sbjct: 306 EALKERVDELTTDLEILKAEIEE-------KGSD--GAASSYQLKQLEEQNARLKDALVR 356

Query: 530 AGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALL 589
              +   +E  E ++ LQ+ ++  N  L+ +  +    ++  S     +++++ Q+ A L
Sbjct: 357 MRDLS-SSEKQEHVK-LQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAAL 414

Query: 590 EA-KMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKL 628
            A +M  +  +     ++   E+R    + E +  +  +L
Sbjct: 415 GAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDEL 454


>gi|13259508 dynactin 1 isoform 2 [Homo sapiens]
          Length = 1144

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 74/340 (21%), Positives = 147/340 (43%), Gaps = 38/340 (11%)

Query: 300 GSSSSLDPSLAGCGGDGSSGSGDAHSWDTLLRKWEPVLRDCLLRNRRQM--------EVI 351
           G+SSSL PS +   G+ SS      +   L     P++   +L +   +        E  
Sbjct: 28  GASSSLGPSGSASAGELSSSEPSTPAQTPLAA---PIIPTPVLTSPGAVPPLPSPSKEEE 84

Query: 352 SLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQ 411
            LR +++ L+E  +E     +AE  + +L++LE+ KI L      +     S +    A 
Sbjct: 85  GLRAQVRDLEEK-LETLRLKRAED-KAKLKELEKHKIQLE-----QVQEWKSKMQEQQAD 137

Query: 412 VQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQ--DSLHVSITRRDWLLQEKQQLQKEI 469
           +Q  L+    +          L  + R +E  A   D++ ++   ++   +  + LQ+E+
Sbjct: 138 LQRRLKEARKEAKEA------LEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEV 191

Query: 470 EALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLAS 529
           EAL+ R+  L    + L+ EIEE       +G D         L QL+E +  L+D L  
Sbjct: 192 EALKERVDELTTDLEILKAEIEE-------KGSD--GAASSYQLKQLEEQNARLKDALVR 242

Query: 530 AGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALL 589
              +   +E  E ++ LQ+ ++  N  L+ +  +    ++  S     +++++ Q+ A L
Sbjct: 243 MRDLS-SSEKQEHVK-LQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAAL 300

Query: 590 EA-KMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKL 628
            A +M  +  +     ++   E+R    + E +  +  +L
Sbjct: 301 GAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDEL 340


>gi|13259510 dynactin 1 isoform 1 [Homo sapiens]
          Length = 1278

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 74/340 (21%), Positives = 147/340 (43%), Gaps = 38/340 (11%)

Query: 300 GSSSSLDPSLAGCGGDGSSGSGDAHSWDTLLRKWEPVLRDCLLRNRRQM--------EVI 351
           G+SSSL PS +   G+ SS      +   L     P++   +L +   +        E  
Sbjct: 162 GASSSLGPSGSASAGELSSSEPSTPAQTPLAA---PIIPTPVLTSPGAVPPLPSPSKEEE 218

Query: 352 SLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQ 411
            LR +++ L+E  +E     +AE  + +L++LE+ KI L      +     S +    A 
Sbjct: 219 GLRAQVRDLEEK-LETLRLKRAED-KAKLKELEKHKIQLE-----QVQEWKSKMQEQQAD 271

Query: 412 VQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQ--DSLHVSITRRDWLLQEKQQLQKEI 469
           +Q  L+    +          L  + R +E  A   D++ ++   ++   +  + LQ+E+
Sbjct: 272 LQRRLKEARKEAKEA------LEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEV 325

Query: 470 EALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLAS 529
           EAL+ R+  L    + L+ EIEE       +G D         L QL+E +  L+D L  
Sbjct: 326 EALKERVDELTTDLEILKAEIEE-------KGSD--GAASSYQLKQLEEQNARLKDALVR 376

Query: 530 AGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALL 589
              +   +E  E ++ LQ+ ++  N  L+ +  +    ++  S     +++++ Q+ A L
Sbjct: 377 MRDLS-SSEKQEHVK-LQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAAL 434

Query: 590 EA-KMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKL 628
            A +M  +  +     ++   E+R    + E +  +  +L
Sbjct: 435 GAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDEL 474


>gi|31982906 cingulin-like 1 [Homo sapiens]
          Length = 1302

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 53/201 (26%), Positives = 93/201 (46%), Gaps = 24/201 (11%)

Query: 341  LLRNRRQMEVISLRLKLQKLQEDAVENDDYDKAETLQQRL--EDLEQEKISLHFQ---LP 395
            L   R   +++S R+   + Q + + N      E LQ+R   +DLE +KISL  Q   L 
Sbjct: 1077 LEEERNNSDLLSERISRSREQMEQLRN------ELLQERAARQDLECDKISLERQNKDLK 1130

Query: 396  SR----QPALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQ------ 445
            SR    + +  S    L  Q++A +     +  S +     L++  R LE   +      
Sbjct: 1131 SRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQV 1190

Query: 446  DSLHVSIT-RRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDL 504
            D  H+S+T ++D L    + +++++E  +  +  LE+  ++L+RE+EEQ    +     L
Sbjct: 1191 DDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQL 1250

Query: 505  TPLVGQLSLGQLQEVSKALQD 525
              +   L L +L   SK L D
Sbjct: 1251 NSMKKDLRLKKLP--SKVLDD 1269



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 76/368 (20%), Positives = 152/368 (41%), Gaps = 38/368 (10%)

Query: 314 GDGSSGSGDAHSWDTLLRKWEPVLRDCLLRNRRQMEVIS----------LRLKLQKLQED 363
           G+  + +  +   D L +K +  +    L+ + Q+EV +          +R  L++L+  
Sbjct: 598 GNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQ 657

Query: 364 AVENDDYDKAETLQQRLEDLEQE---KISLHFQLPSRQPALSSFLGHLAAQVQAALRRGA 420
              N+  ++  TLQQRLE+ E E    +   FQ+   +    + +  L  Q+        
Sbjct: 658 --HNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELD 715

Query: 421 TQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLE 480
           + + S D     L  E    +   QD L     + D L + +++L     AL+  +   +
Sbjct: 716 SAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHD 775

Query: 481 AKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPP 540
            +  +L+ + + + Q L+    + T  V  L+       + + QD   +  ++    E  
Sbjct: 776 QEMDKLKEQYDAELQALRESVEEATKNVEVLA----SRSNTSEQDQAGTEMRVKLLQEEN 831

Query: 541 ETIR----SLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAI 596
           E ++     L+ R+  L   ++++      +++   TL+K     E ++  L EA +HA 
Sbjct: 832 EKLQGRSEELERRVAQLQRQIEDLKGDEAKAKE---TLKK----YEGEIRQLEEALVHAR 884

Query: 597 SGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLS---SRNVKKLGSVKEDYNRLRREV 653
                   K+     R+L +E E  +G LS+        S  +K+    KE   RL+ E+
Sbjct: 885 K-----EEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEM 939

Query: 654 EHQETAYG 661
           E++    G
Sbjct: 940 ENERWHLG 947



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 57/290 (19%), Positives = 118/290 (40%), Gaps = 24/290 (8%)

Query: 300  GSSSSLDPSLAGCGGDGSSGSGDAHSWDTLLRKWEPVLR---DCLLRNRRQ-MEVISLRL 355
            G S  L+  +A          GD       L+K+E  +R   + L+  R++  E +S R 
Sbjct: 836  GRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARR 895

Query: 356  KLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQVQAA 415
             L+   E A  N      E  Q++L +  +E+     QL   +  + +   HL   ++  
Sbjct: 896  ALENELEAAQGNLSQTTQE--QKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEK- 952

Query: 416  LRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQAR 475
            L++          T T        LE   Q   +    RR+    ++Q  +K +EA ++R
Sbjct: 953  LQKEMADIVEASRTST--------LELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSR 1004

Query: 476  MFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPF 535
            +  ++ +D+    E E ++ Q   +  D      QL    L++  K L+  L +   +  
Sbjct: 1005 LTAMKMQDEMRLMEEELRDYQ---RAQDEALTKRQL----LEQTLKDLEYELEAKSHL-- 1055

Query: 536  HAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQL 585
              +    ++ +++++  L + L+E      +  +  S  R+++  +  +L
Sbjct: 1056 KDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNEL 1105



 Score = 30.8 bits (68), Expect = 4.3
 Identities = 22/102 (21%), Positives = 48/102 (47%), Gaps = 2/102 (1%)

Query: 575 RKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSR 634
           ++KVN +  ++  L      +  GN+   A + T E++ L  ++  L   +++L      
Sbjct: 575 KRKVNLVFEKIQTLKSRAAGSAQGNN--QACNSTSEVKDLLEQKSKLTIEVAELQRQLQL 632

Query: 635 NVKKLGSVKEDYNRLRREVEHQETAYGYKYCDAESWTQRSQQ 676
            VK   ++KE+  R+R  +E   + +  K  +  +  QR ++
Sbjct: 633 EVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEE 674


>gi|63252896 tropomyosin 1 alpha chain isoform 3 [Homo sapiens]
          Length = 284

 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 57/267 (21%), Positives = 110/267 (41%), Gaps = 36/267 (13%)

Query: 348 MEVISLRLKLQKLQE----DAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSS 403
           M+ I  ++++ KL +    D  E  + DK +  + R + LE E +SL  +L   +  L  
Sbjct: 1   MDAIKKKMQMLKLDKENALDRAEQAEADK-KAAEDRSKQLEDELVSLQKKLKGTEDELDK 59

Query: 404 FLGHLA-AQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEK 462
           +   L  AQ +  L       A  D      R++        ++ L  +  R    LQ+ 
Sbjct: 60  YSEALKDAQEKLELAEKKATDAEADVASLNRRIQ------LVEEELDRAQERLATALQKL 113

Query: 463 QQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQW----------------------- 499
           ++ +K  +  +  M V+E++ Q+   ++E QE QL+                        
Sbjct: 114 EEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIE 173

Query: 500 QGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEP-PETIRSLQERIKSLNLSLK 558
              +      +LS G+  E+ + L+    +   +   AE   +     +E IK L+  LK
Sbjct: 174 SDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLK 233

Query: 559 EITTKVCMSEKFCSTLRKKVNDIETQL 585
           E  T+   +E+  + L K ++D+E ++
Sbjct: 234 EAETRAEFAERSVTKLEKSIDDLEEKV 260


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.130    0.382 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,893,581
Number of Sequences: 37866
Number of extensions: 1467692
Number of successful extensions: 9450
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 77
Number of HSP's successfully gapped in prelim test: 533
Number of HSP's that attempted gapping in prelim test: 7809
Number of HSP's gapped (non-prelim): 1765
length of query: 678
length of database: 18,247,518
effective HSP length: 109
effective length of query: 569
effective length of database: 14,120,124
effective search space: 8034350556
effective search space used: 8034350556
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.