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Search of human proteins with 59806361
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|59806361 hypothetical protein LOC387104 [Homo sapiens]
(947 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|59806361 hypothetical protein LOC387104 [Homo sapiens] 1864 0.0
gi|163644316 hypothetical protein LOC23255 [Homo sapiens] 570 e-162
gi|66773344 hypothetical protein LOC140710 [Homo sapiens] 418 e-116
gi|40068464 AT rich interactive domain 1B (SWI1-like) isoform 2 ... 84 6e-16
gi|40068466 AT rich interactive domain 1B (SWI1-like) isoform 1 ... 84 6e-16
gi|40068462 AT rich interactive domain 1B (SWI1-like) isoform 3 ... 84 6e-16
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 84 8e-16
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 84 8e-16
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 84 8e-16
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 84 8e-16
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 83 1e-15
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 83 1e-15
gi|148612801 KIAA1009 protein [Homo sapiens] 76 1e-13
gi|58530840 desmoplakin isoform I [Homo sapiens] 75 2e-13
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 75 2e-13
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens] 75 3e-13
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 75 4e-13
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 75 4e-13
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 75 4e-13
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 75 4e-13
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 75 4e-13
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 75 4e-13
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 75 4e-13
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 75 4e-13
gi|148762940 DVL-binding protein DAPLE [Homo sapiens] 75 4e-13
gi|4502443 dystonin isoform 1e precursor [Homo sapiens] 74 8e-13
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 74 8e-13
gi|33457336 chromosome 14 open reading frame 4 [Homo sapiens] 74 8e-13
gi|21735548 centrosomal protein 2 [Homo sapiens] 72 2e-12
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 72 3e-12
>gi|59806361 hypothetical protein LOC387104 [Homo sapiens]
Length = 947
Score = 1864 bits (4829), Expect = 0.0
Identities = 947/947 (100%), Positives = 947/947 (100%)
Query: 1 MSQPPIGGAAPATAAASPAAAATEARLHPEGSSRKQQRAQSPARPRDSSLRQTIAATRSP 60
MSQPPIGGAAPATAAASPAAAATEARLHPEGSSRKQQRAQSPARPRDSSLRQTIAATRSP
Sbjct: 1 MSQPPIGGAAPATAAASPAAAATEARLHPEGSSRKQQRAQSPARPRDSSLRQTIAATRSP 60
Query: 61 VGAGTKLNSVRQQQLQQQQQQGNKTGSRTGPPASIRGGGGGAEKATPLAPKGAAPGAVQP 120
VGAGTKLNSVRQQQLQQQQQQGNKTGSRTGPPASIRGGGGGAEKATPLAPKGAAPGAVQP
Sbjct: 61 VGAGTKLNSVRQQQLQQQQQQGNKTGSRTGPPASIRGGGGGAEKATPLAPKGAAPGAVQP 120
Query: 121 VAGAEAAPAATLAALGGRRPGPPEEPPRELESVPSKLGEPPPLGEGGGGGGEGGGAGGGS 180
VAGAEAAPAATLAALGGRRPGPPEEPPRELESVPSKLGEPPPLGEGGGGGGEGGGAGGGS
Sbjct: 121 VAGAEAAPAATLAALGGRRPGPPEEPPRELESVPSKLGEPPPLGEGGGGGGEGGGAGGGS 180
Query: 181 GEREGGAPQPPPPRGWRGKGVRAQQRGGSGGEGASPSPSSSSAGKTPGTGSRNSGSGVAG 240
GEREGGAPQPPPPRGWRGKGVRAQQRGGSGGEGASPSPSSSSAGKTPGTGSRNSGSGVAG
Sbjct: 181 GEREGGAPQPPPPRGWRGKGVRAQQRGGSGGEGASPSPSSSSAGKTPGTGSRNSGSGVAG 240
Query: 241 GGSGGGGSYWKEGCLQSELIQFHLKKERAAAAAAAAQMHAKNGGGSSSRSSPVSGPPAVC 300
GGSGGGGSYWKEGCLQSELIQFHLKKERAAAAAAAAQMHAKNGGGSSSRSSPVSGPPAVC
Sbjct: 241 GGSGGGGSYWKEGCLQSELIQFHLKKERAAAAAAAAQMHAKNGGGSSSRSSPVSGPPAVC 300
Query: 301 ETLAVASASPMAAAAEGPQQSAEGSASGGGMQAAAPPSSQPHPQQLQEQEEMQEEMEKLR 360
ETLAVASASPMAAAAEGPQQSAEGSASGGGMQAAAPPSSQPHPQQLQEQEEMQEEMEKLR
Sbjct: 301 ETLAVASASPMAAAAEGPQQSAEGSASGGGMQAAAPPSSQPHPQQLQEQEEMQEEMEKLR 360
Query: 361 EENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERANKNCRILQYRLRKAERKR 420
EENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERANKNCRILQYRLRKAERKR
Sbjct: 361 EENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERANKNCRILQYRLRKAERKR 420
Query: 421 LRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTTEDENEKLRQQLIEVE 480
LRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTTEDENEKLRQQLIEVE
Sbjct: 421 LRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTTEDENEKLRQQLIEVE 480
Query: 481 IAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTEEDNEDLKCQLQFVKEEAALMR 540
IAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTEEDNEDLKCQLQFVKEEAALMR
Sbjct: 481 IAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTEEDNEDLKCQLQFVKEEAALMR 540
Query: 541 KKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGEAGGPPSTREAELKLRLRLVEEEANI 600
KKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGEAGGPPSTREAELKLRLRLVEEEANI
Sbjct: 541 KKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGEAGGPPSTREAELKLRLRLVEEEANI 600
Query: 601 LGRKIVELEVENRGLKAELDDLRGDDFNGSANPLMREQSESLSELRQHLQLVEDETELLR 660
LGRKIVELEVENRGLKAELDDLRGDDFNGSANPLMREQSESLSELRQHLQLVEDETELLR
Sbjct: 601 LGRKIVELEVENRGLKAELDDLRGDDFNGSANPLMREQSESLSELRQHLQLVEDETELLR 660
Query: 661 RNVADLEEQNKRITAELNKYKYKSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVM 720
RNVADLEEQNKRITAELNKYKYKSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVM
Sbjct: 661 RNVADLEEQNKRITAELNKYKYKSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVM 720
Query: 721 QLQYENRVLMSNMQRYDLASHLGIRGSPRDSDAESDAGKKESDDDSRPPHRKREGPIGGE 780
QLQYENRVLMSNMQRYDLASHLGIRGSPRDSDAESDAGKKESDDDSRPPHRKREGPIGGE
Sbjct: 721 QLQYENRVLMSNMQRYDLASHLGIRGSPRDSDAESDAGKKESDDDSRPPHRKREGPIGGE 780
Query: 781 SDSEEVRNIRCLTPTRSFYPAPGPWPKSFSDRQQMKDIRSEAERLGKTIDRLIADTSTII 840
SDSEEVRNIRCLTPTRSFYPAPGPWPKSFSDRQQMKDIRSEAERLGKTIDRLIADTSTII
Sbjct: 781 SDSEEVRNIRCLTPTRSFYPAPGPWPKSFSDRQQMKDIRSEAERLGKTIDRLIADTSTII 840
Query: 841 TEARIYVANGDLFGLMDEEDDGSRIREHELLYRINAQMKAFRKELQTFIDRLEVPKSADD 900
TEARIYVANGDLFGLMDEEDDGSRIREHELLYRINAQMKAFRKELQTFIDRLEVPKSADD
Sbjct: 841 TEARIYVANGDLFGLMDEEDDGSRIREHELLYRINAQMKAFRKELQTFIDRLEVPKSADD 900
Query: 901 RGAEEPISVSQMFQPIILLILILVLFSSLSYTTIFKLVFLFTLFFVL 947
RGAEEPISVSQMFQPIILLILILVLFSSLSYTTIFKLVFLFTLFFVL
Sbjct: 901 RGAEEPISVSQMFQPIILLILILVLFSSLSYTTIFKLVFLFTLFFVL 947
>gi|163644316 hypothetical protein LOC23255 [Homo sapiens]
Length = 1586
Score = 570 bits (1469), Expect = e-162
Identities = 313/539 (58%), Positives = 400/539 (74%), Gaps = 29/539 (5%)
Query: 377 MDEMRDTFFEEDACQLQEMRHELERANKNCRILQYRLRKAERKRLRYAQTGEIDGELLRS 436
M+EMRD++ EED QLQE+R EL+RANKNCRILQYRLRKAE+K L+ A+TG++DGEL+RS
Sbjct: 1 MEEMRDSYLEEDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRS 60
Query: 437 LEQDLKVAKDVSVRLHHELENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKEL 496
LEQDLKVAKDVSVRLHHEL+ VEEKR EDENE LRQQ+IEVEI+KQALQNELE++KE
Sbjct: 61 LEQDLKVAKDVSVRLHHELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNELERLKES 120
Query: 497 SLKRRGSKDLPKSEKKAQQTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHE 556
SLKRR ++++ K +K T ++D+ DL+CQLQF KEEA LMRKKMAK+ +EKD E E
Sbjct: 121 SLKRRSTREMYKEKK----TFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQE 176
Query: 557 LQKYRSFYGDLDSPLPKGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLK 616
LQKY+S YGD+DSPLP GEAGGPPSTREAELKLRL+LVEEEANILGRKIVELEVENRGLK
Sbjct: 177 LQKYKSLYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENRGLK 236
Query: 617 AELDDLRG---------DDFNGSANPLMREQSESLSELRQHLQLVEDETELLRRNVADLE 667
AE++D+RG D + ES +ELR+HLQ VE+E ELLRR+++++E
Sbjct: 237 AEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIE 296
Query: 668 EQNKRITAELNKYKY----KSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVMQLQ 723
+ N+++T EL+K+K+ + G LQEELK+ARLQI+ELSGKV++LQ
Sbjct: 297 DHNRQLTHELSKFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQ 356
Query: 724 YENRVLMSNMQRYDLASHLGIRG-SPRDSDAESDAGKKESD-DDSRPPHRKREGPIGGES 781
+EN L+SN+QR DLA+HLG+R SPRDSDAESDAGKKESD ++SR P KREGP+GGES
Sbjct: 357 HENHALLSNIQRCDLAAHLGLRAPSPRDSDAESDAGKKESDGEESRLPQPKREGPVGGES 416
Query: 782 DSEEV----RNIRCLTPTRSFYPAPGPWPKSFSDRQQMKDIRSEAERLGKTIDRLIADTS 837
DSEE+ P+ + P P K+ D + + ++ EA+RL +T++RLI DT
Sbjct: 417 DSEEMFEKTSGFGSGKPSEASEPCPTELLKAREDSEYLVTLKHEAQRLERTVERLITDTD 476
Query: 838 TIITEARIYVANGDLF---GLMDEEDDG-SRIREHELLYRINAQMKAFRKELQTFIDRL 892
+ + +A + G GL EE+ G +E +LL INA+MKAF+KELQ F++++
Sbjct: 477 SFLHDAGL--RGGAPLPGPGLQGEEEQGEGDQQEPQLLGTINAKMKAFKKELQAFLEQV 533
Score = 77.4 bits (189), Expect = 6e-14
Identities = 70/300 (23%), Positives = 136/300 (45%), Gaps = 39/300 (13%)
Query: 348 EQEEMQEEMEKLREENETLK--------------NEIDELR---------TEMDEMRDTF 384
E + ++E+ K +ENETL+ NE++ L+ EM + + TF
Sbjct: 78 ELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNELERLKESSLKRRSTREMYKEKKTF 137
Query: 385 FEEDA----CQLQEMRHELERANKNCRILQYRLRKAERKRLRYAQT-GEIDGELLRSLEQ 439
++D+ CQLQ + E K L + E++ +Y G++D L
Sbjct: 138 NQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDVDSPLPTGEAG 197
Query: 440 DLKVAKDVSVRLHHELENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLK 499
++ ++L +L E+E L ++++E+E+ + L+ E+E M+ +
Sbjct: 198 GPPSTREAELKLRLKL---------VEEEANILGRKIVELEVENRGLKAEMEDMRGQQER 248
Query: 500 RRGSKDLPKSEKKAQQTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQK 559
+D S + + E + +L+ LQFV+EEA L+R+ +++I+ + HEL K
Sbjct: 249 EGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSK 308
Query: 560 YRSFYGDLDSPLPKGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAEL 619
++ + P GE P + A L+ L+ + + L K+++L+ EN L + +
Sbjct: 309 FK--FEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHENHALLSNI 366
>gi|66773344 hypothetical protein LOC140710 [Homo sapiens]
Length = 1016
Score = 418 bits (1075), Expect = e-116
Identities = 251/544 (46%), Positives = 338/544 (62%), Gaps = 47/544 (8%)
Query: 377 MDEMRDTFFEEDACQLQEMRHELERANKNCRILQYRLRKAERKRLRYAQTGEIDGELLRS 436
M EMRD + EED QLQE+R +L++A+K CRILQYRLRKAER+ LR AQTG++DGEL+R
Sbjct: 1 MLEMRDVYMEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRG 60
Query: 437 LEQDLKVAKDVSVRLHHELENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKEL 496
LEQD+KV+KD+S+RLH ELE VE+KR E+ENE+LRQ+LIE E+AKQ LQ ELE+ +E
Sbjct: 61 LEQDVKVSKDISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREH 120
Query: 497 SLKRRGSKDLPKSEKKAQQTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHE 556
SLK+RG++ L K++KK T +ED+ DLKCQL F KEE+ALM KK+ K+ KE D + E
Sbjct: 121 SLKKRGTRSLGKADKK---TLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEE 177
Query: 557 LQKYRSFYGDLDSPLPKGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLK 616
L KYRS YGDLDS L E P +RE ELK+ L+LVEEEAN+L R+IVELEVENRGL+
Sbjct: 178 LLKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLR 237
Query: 617 AELDDLRGDDFNGSANPLMR---------EQSESLSELRQHLQLVEDETELLRRNVADLE 667
AE+DD++ D G P R E ESL+ELR+HLQ VE+E ELLRR+ A+LE
Sbjct: 238 AEMDDMK-DHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELE 296
Query: 668 EQNKRITAELNKYKYKSGGHDSARHHDNAK--TEALQEELKAARLQINELSGKVMQLQYE 725
+QNK + EL K++ D A D+ +E QEEL AA+LQI ELSGKV +LQYE
Sbjct: 297 DQNKLLLNELAKFR-SEHELDVALSEDSCSVLSEPSQEELAAAKLQIGELSGKVKKLQYE 355
Query: 726 NRVLMSNMQRYDLASHLGIRGSPRDSDAESDAGKKESDDDSRPPHRKREGPIGGESDSEE 785
NRVL+SN+QR DLAS +S E+D ++ + P+G +S
Sbjct: 356 NRVLLSNLQRCDLAS------------CQSTRPMLETDAEAGDSAQCVPAPLGETHESHA 403
Query: 786 VRNIRCLTPTRSFYPAPGPWPKSFSDRQQMKDIRSEAERLGKTIDRLIADTSTIITEARI 845
VR R + + + +R +A + K ID L+AD + R+
Sbjct: 404 VRLCRA------------------REAEVLPGLREQAALVSKAIDVLVADANGFTAGLRL 445
Query: 846 YVANGDL-FGLMDEEDDGSRIREHELLYRINAQMKAFRKELQTFIDRLEVPKSADDRGAE 904
+ N F L + D+ R+ +L++ I ++ ++EL F + + + +
Sbjct: 446 CLDNECADFRLHEAPDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQ 505
Query: 905 EPIS 908
E S
Sbjct: 506 ESFS 509
Score = 37.0 bits (84), Expect = 0.087
Identities = 27/104 (25%), Positives = 51/104 (49%), Gaps = 5/104 (4%)
Query: 317 GPQQSAEGSASGGGMQAAAPPSSQPHPQQLQEQEEM-QEEMEKLREENETLKNEIDELRT 375
GP+ SA GGG + + H Q ++E+ E+ + +L ++N+ L NE+ + R+
Sbjct: 252 GPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNKLLLNELAKFRS 311
Query: 376 EMDEMRDTFFEEDACQL--QEMRHELERANKNCRILQYRLRKAE 417
E + D ED+C + + + EL A L +++K +
Sbjct: 312 EHE--LDVALSEDSCSVLSEPSQEELAAAKLQIGELSGKVKKLQ 353
>gi|40068464 AT rich interactive domain 1B (SWI1-like) isoform 2
[Homo sapiens]
Length = 2191
Score = 84.0 bits (206), Expect = 6e-16
Identities = 93/332 (28%), Positives = 121/332 (36%), Gaps = 69/332 (20%)
Query: 66 KLNSVRQQQLQQQQQQGNKTGSR--TGPPASIRGGGGGAEKATPLAPKGAAPGAVQPVAG 123
+LN +QQQ QQQQQQ + + S+ G GGGA + P + GA AG
Sbjct: 51 QLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAG 110
Query: 124 AEAAPAATLAALGGRRPGPP-EEPPRELESVPSKLGEP-----------------PPLGE 165
+A P PGPP P + + P K+GEP PP+
Sbjct: 111 GQADP-----------PGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAV 159
Query: 166 GGGGGG----------------EGGGAGGGSG---EREGGAPQPPPPRGWRGKGVRAQQR 206
GGGGG GG GG +G ++ GG P G G+
Sbjct: 160 PGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSP-------GMGMMHSAS 212
Query: 207 GGSGGEGASPSP--------SSSSAGKTPGTGSRNSGSGVAGGGSGGGGSYWKEGCLQSE 258
+ G S P +S PG +G G GGG GGGGS G +
Sbjct: 213 AAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAG 272
Query: 259 LIQFHLKKERAAAAAAAAQMHAKNGGGSSSRSSPVSGPPAVCETLAVASASPMAAAAEGP 318
AAAAAAAA GGG S+ + + P A
Sbjct: 273 AGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAASL 332
Query: 319 QQSAEGSASGGGMQAAA----PPSSQPHPQQL 346
++A GSA+GG + A P + P QL
Sbjct: 333 SKAAAGSAAGGFQRFAGQNQHPSGATPTLNQL 364
Score = 74.7 bits (182), Expect = 4e-13
Identities = 81/283 (28%), Positives = 104/283 (36%), Gaps = 41/283 (14%)
Query: 91 PPASIRGGGGGAEKATPL-------APKGAAPGAV----------QPVAGAEAAPAATLA 133
PP ++ GGGGG AP PG Q G +A+ A
Sbjct: 155 PPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSASAA 214
Query: 134 ALGGRRPGPPEEPPRELESVPSKLGEPPP----LGEGGGGGGEGGGAGGGSGEREGGAPQ 189
A G PG + E P+ P G GGGGGG GGG GGGSG GG
Sbjct: 215 AAGA--PGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGG-GGGGGGGSGGGGGGGGA 271
Query: 190 PPPPRGWRGKGVRAQQRGGSGGEGASPSPSSSSAGKTPGTGSRNSGSGVAGGGSGGGGSY 249
G A + G G SSAG + R G G+ G GGG +
Sbjct: 272 GAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAAS 331
Query: 250 WKE---GCLQSELIQFHLKKERAAAA--------AAAAQMHAKNGGGSSSRSSPVSGPPA 298
+ G +F + + + A + + M GG SSP + PP
Sbjct: 332 LSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPP 391
Query: 299 VCETLAVASASPMAAAAEGPQQSAEGSASG---GGMQAAAPPS 338
+ + A+A A AA G QQ+A G G G AAA P+
Sbjct: 392 PSQPQSQAAA---AGAAAGGQQAAAGMGLGKDMGAQYAAASPA 431
Score = 37.4 bits (85), Expect = 0.067
Identities = 85/377 (22%), Positives = 118/377 (31%), Gaps = 89/377 (23%)
Query: 14 AAASPAAAATEARLHPEGSSRKQQRAQSPARPRDSSLRQTIAATRSPVGAGTKLNSVRQQ 73
AAASPA AA + R HP A SP P + R + V +L +
Sbjct: 426 AAASPAWAAAQQRSHP---------AMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSN 476
Query: 74 QLQQQQQQGNKTGSRTGPPASIRGGGGGAEKATPLAPKGAAPGAV------QPVAGAEAA 127
Q QQ G GPP R P+ +G PGA+ Q +A
Sbjct: 477 PHSQPQQSSPYPGGSYGPPGPQR---------YPIGIQGRTPGAMAGMQYPQQQDSGDAT 527
Query: 128 PAATLAALG--------------------GRRPGPPEEPPRE--LESVPSKLGEPPP--L 163
T + ++P PP PP+ L S + +P
Sbjct: 528 WKETFWLMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMS 587
Query: 164 GEGGGGGGEGGGAGGGSG---------EREGGAPQ--------PPPPRGWRGKGVRAQQR 206
EG G + A G ER P P V A
Sbjct: 588 QEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLPDLSGSIDDLPTGTEATLSSAVSASGS 647
Query: 207 GGSGGEGASPSPSSSSAGKTPGTGSRNSGSGVAGGGSGGGGSYWKEGCLQSELIQFHLKK 266
S G+ ++P+ S S +P S G + GS G + + G +
Sbjct: 648 TSSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPI----------- 696
Query: 267 ERAAAAAAAAQMHAKNGGGSSSRSSPVSGPPAVCETLAVASASPMAAAAEGPQQSAEGSA 326
+ A+ +QM + G S SS PA+ ++ MA PQ + G
Sbjct: 697 --SPASIPGSQMPPQPPGSQSESSS----HPALSQSPMPQERGFMAGTQRNPQMAQYGPQ 750
Query: 327 SGGGMQAAAPPSSQPHP 343
G PS PHP
Sbjct: 751 QTG-------PSMSPHP 760
Score = 30.4 bits (67), Expect = 8.2
Identities = 49/203 (24%), Positives = 73/203 (35%), Gaps = 33/203 (16%)
Query: 67 LNSVRQQQLQQQQQQGNKT-GSRTGPPASIRGGGGGAEKATPLAPKGAAP-----GAVQP 120
L S QQ+ Q QQ + G+R+ PP + G E + + + G++
Sbjct: 572 LPSQSQQRYQPQQDMSQEGYGTRSQPP--LAPGKPNHEDLNLIQQERPSSLPDLSGSIDD 629
Query: 121 V-AGAEAAPAATLAALG-----GRRPGPPEEP--PRELESVPSKLGEPPPLGEGGGGGGE 172
+ G EA ++ ++A G G + P + P P + S G P P G G
Sbjct: 630 LPTGTEATLSSAVSASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSN 689
Query: 173 GGGAGGGSGEREGGAPQPPPPRGWRGKGVRAQQRGGSGGEGASPSPSSSSAGKTPGT--- 229
+G S G+ PP P G Q S S SP G GT
Sbjct: 690 QSRSGPISPASIPGSQMPPQPPG--------SQSESSSHPALSQSPMPQERGFMAGTQRN 741
Query: 230 ------GSRNSGSGVAGGGSGGG 246
G + +G ++ S GG
Sbjct: 742 PQMAQYGPQQTGPSMSPHPSPGG 764
>gi|40068466 AT rich interactive domain 1B (SWI1-like) isoform 1
[Homo sapiens]
Length = 2231
Score = 84.0 bits (206), Expect = 6e-16
Identities = 93/332 (28%), Positives = 121/332 (36%), Gaps = 69/332 (20%)
Query: 66 KLNSVRQQQLQQQQQQGNKTGSR--TGPPASIRGGGGGAEKATPLAPKGAAPGAVQPVAG 123
+LN +QQQ QQQQQQ + + S+ G GGGA + P + GA AG
Sbjct: 51 QLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAG 110
Query: 124 AEAAPAATLAALGGRRPGPP-EEPPRELESVPSKLGEP-----------------PPLGE 165
+A P PGPP P + + P K+GEP PP+
Sbjct: 111 GQADP-----------PGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAV 159
Query: 166 GGGGGG----------------EGGGAGGGSG---EREGGAPQPPPPRGWRGKGVRAQQR 206
GGGGG GG GG +G ++ GG P G G+
Sbjct: 160 PGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSP-------GMGMMHSAS 212
Query: 207 GGSGGEGASPSP--------SSSSAGKTPGTGSRNSGSGVAGGGSGGGGSYWKEGCLQSE 258
+ G S P +S PG +G G GGG GGGGS G +
Sbjct: 213 AAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAG 272
Query: 259 LIQFHLKKERAAAAAAAAQMHAKNGGGSSSRSSPVSGPPAVCETLAVASASPMAAAAEGP 318
AAAAAAAA GGG S+ + + P A
Sbjct: 273 AGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAASL 332
Query: 319 QQSAEGSASGGGMQAAA----PPSSQPHPQQL 346
++A GSA+GG + A P + P QL
Sbjct: 333 SKAAAGSAAGGFQRFAGQNQHPSGATPTLNQL 364
Score = 74.7 bits (182), Expect = 4e-13
Identities = 81/283 (28%), Positives = 104/283 (36%), Gaps = 41/283 (14%)
Query: 91 PPASIRGGGGGAEKATPL-------APKGAAPGAV----------QPVAGAEAAPAATLA 133
PP ++ GGGGG AP PG Q G +A+ A
Sbjct: 155 PPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSASAA 214
Query: 134 ALGGRRPGPPEEPPRELESVPSKLGEPPP----LGEGGGGGGEGGGAGGGSGEREGGAPQ 189
A G PG + E P+ P G GGGGGG GGG GGGSG GG
Sbjct: 215 AAGA--PGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGG-GGGGGGGSGGGGGGGGA 271
Query: 190 PPPPRGWRGKGVRAQQRGGSGGEGASPSPSSSSAGKTPGTGSRNSGSGVAGGGSGGGGSY 249
G A + G G SSAG + R G G+ G GGG +
Sbjct: 272 GAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAAS 331
Query: 250 WKE---GCLQSELIQFHLKKERAAAA--------AAAAQMHAKNGGGSSSRSSPVSGPPA 298
+ G +F + + + A + + M GG SSP + PP
Sbjct: 332 LSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPP 391
Query: 299 VCETLAVASASPMAAAAEGPQQSAEGSASG---GGMQAAAPPS 338
+ + A+A A AA G QQ+A G G G AAA P+
Sbjct: 392 PSQPQSQAAA---AGAAAGGQQAAAGMGLGKDMGAQYAAASPA 431
Score = 42.7 bits (99), Expect = 0.002
Identities = 101/432 (23%), Positives = 143/432 (33%), Gaps = 86/432 (19%)
Query: 3 QPPI----GGAAPATA--------AASPAAAATEARLHPEGSSRKQQRAQSPARPRDSSL 50
QPP+ GG PA +A+PA+ R P Q QSP +
Sbjct: 154 QPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQ--QSPG------M 205
Query: 51 RQTIAATRSPVGAGTKLNSVRQQQLQQQQQQGNKTGSRTGPPASIRGGGGGAEKA-TPLA 109
+A+ + GA ++ ++ Q N + P A GGGGG +
Sbjct: 206 GMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGG 265
Query: 110 PKGAAPGAVQPVAGAEAAPAATLAALGGRRPGPP---EEPPRELESVPSKLGEPPPLGEG 166
G GA AGA AA AA AA G G + S P + G +G G
Sbjct: 266 GGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPG 325
Query: 167 GGGGGE------GGGAGG-----GSGEREGGAPQPPPPRGWRGKGVRAQQRGGSGGEGAS 215
GGG G AGG G + GA P + + GGS E +S
Sbjct: 326 GGGAASLSKAAAGSAAGGFQRFAGQNQHPSGAT-PTLNQLLTSPSPMMRSYGGSYPEYSS 384
Query: 216 PS--------PSSSSAGKTPGTGSRNSGSGVAGGGSGGGGSY------WKEGCLQSELIQ 261
PS P S +A G + + +G+ G G G Y W +S
Sbjct: 385 PSAPPPPPSQPQSQAAAAGAAAGGQQAAAGM-GLGKDMGAQYAAASPAWAAAQQRSHPAM 443
Query: 262 FHLKKERAAAAAAAAQMHAK-------NGGGSSSRSSPVS---------GPPAVCE-TLA 304
+ + M G GS+ S P GPP +
Sbjct: 444 SPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIG 503
Query: 305 VASASPMAAAA------EGPQQSAEGSASGGGMQAAAP------------PSSQPHPQQL 346
+ +P A A + P Q + SG Q P P +Q P Q
Sbjct: 504 IQGRTPGAMAGMQYPQQQMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQS 563
Query: 347 QEQEEMQEEMEK 358
Q++ + Q++M +
Sbjct: 564 QQRYQPQQDMSQ 575
Score = 42.4 bits (98), Expect = 0.002
Identities = 83/364 (22%), Positives = 116/364 (31%), Gaps = 76/364 (20%)
Query: 14 AAASPAAAATEARLHPEGSSRKQQRAQSPARPRDSSLRQTIAATRSPVGAGTKLNSVRQQ 73
AAASPA AA + R HP A SP P + R + V +L +
Sbjct: 426 AAASPAWAAAQQRSHP---------AMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSN 476
Query: 74 QLQQQQQQGNKTGSRTGPPASIRGGGGGAEKATPLAPKGAAPGAVQPVAGAEAAPAATLA 133
Q QQ G GPP R P+ +G PGA+ + +
Sbjct: 477 PHSQPQQSSPYPGGSYGPPGPQR---------YPIGIQGRTPGAMAGMQYPQQQMPPQYG 527
Query: 134 ALG-------------GRRPGPPEEPPRE--LESVPSKLGEPPP--LGEGGGGGGEGGGA 176
G ++P PP PP+ L S + +P EG G + A
Sbjct: 528 QQGVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLA 587
Query: 177 GGGSG---------EREGGAPQ--------PPPPRGWRGKGVRAQQRGGSGGEGASPSPS 219
G ER P P V A S G+ ++P+ S
Sbjct: 588 PGKPNHEDLNLIQQERPSSLPDLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQS 647
Query: 220 SSSAGKTPGTGSRNSGSGVAGGGSGGGGSYWKEGCLQSELIQFHLKKERAAAAAAAAQMH 279
S +P S G + GS G + + G + + A+ +QM
Sbjct: 648 PFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPI-------------SPASIPGSQMP 694
Query: 280 AKNGGGSSSRSSPVSGPPAVCETLAVASASPMAAAAEGPQQSAEGSASGGGMQAAAPPSS 339
+ G S SS PA+ ++ MA PQ + G G PS
Sbjct: 695 PQPPGSQSESSS----HPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTG-------PSM 743
Query: 340 QPHP 343
PHP
Sbjct: 744 SPHP 747
Score = 30.4 bits (67), Expect = 8.2
Identities = 49/203 (24%), Positives = 73/203 (35%), Gaps = 33/203 (16%)
Query: 67 LNSVRQQQLQQQQQQGNKT-GSRTGPPASIRGGGGGAEKATPLAPKGAAP-----GAVQP 120
L S QQ+ Q QQ + G+R+ PP + G E + + + G++
Sbjct: 559 LPSQSQQRYQPQQDMSQEGYGTRSQPP--LAPGKPNHEDLNLIQQERPSSLPDLSGSIDD 616
Query: 121 V-AGAEAAPAATLAALG-----GRRPGPPEEP--PRELESVPSKLGEPPPLGEGGGGGGE 172
+ G EA ++ ++A G G + P + P P + S G P P G G
Sbjct: 617 LPTGTEATLSSAVSASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSN 676
Query: 173 GGGAGGGSGEREGGAPQPPPPRGWRGKGVRAQQRGGSGGEGASPSPSSSSAGKTPGT--- 229
+G S G+ PP P G Q S S SP G GT
Sbjct: 677 QSRSGPISPASIPGSQMPPQPPG--------SQSESSSHPALSQSPMPQERGFMAGTQRN 728
Query: 230 ------GSRNSGSGVAGGGSGGG 246
G + +G ++ S GG
Sbjct: 729 PQMAQYGPQQTGPSMSPHPSPGG 751
>gi|40068462 AT rich interactive domain 1B (SWI1-like) isoform 3
[Homo sapiens]
Length = 2178
Score = 84.0 bits (206), Expect = 6e-16
Identities = 93/332 (28%), Positives = 121/332 (36%), Gaps = 69/332 (20%)
Query: 66 KLNSVRQQQLQQQQQQGNKTGSR--TGPPASIRGGGGGAEKATPLAPKGAAPGAVQPVAG 123
+LN +QQQ QQQQQQ + + S+ G GGGA + P + GA AG
Sbjct: 51 QLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAG 110
Query: 124 AEAAPAATLAALGGRRPGPP-EEPPRELESVPSKLGEP-----------------PPLGE 165
+A P PGPP P + + P K+GEP PP+
Sbjct: 111 GQADP-----------PGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAV 159
Query: 166 GGGGGG----------------EGGGAGGGSG---EREGGAPQPPPPRGWRGKGVRAQQR 206
GGGGG GG GG +G ++ GG P G G+
Sbjct: 160 PGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSP-------GMGMMHSAS 212
Query: 207 GGSGGEGASPSP--------SSSSAGKTPGTGSRNSGSGVAGGGSGGGGSYWKEGCLQSE 258
+ G S P +S PG +G G GGG GGGGS G +
Sbjct: 213 AAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAG 272
Query: 259 LIQFHLKKERAAAAAAAAQMHAKNGGGSSSRSSPVSGPPAVCETLAVASASPMAAAAEGP 318
AAAAAAAA GGG S+ + + P A
Sbjct: 273 AGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAASL 332
Query: 319 QQSAEGSASGGGMQAAA----PPSSQPHPQQL 346
++A GSA+GG + A P + P QL
Sbjct: 333 SKAAAGSAAGGFQRFAGQNQHPSGATPTLNQL 364
Score = 74.7 bits (182), Expect = 4e-13
Identities = 81/283 (28%), Positives = 104/283 (36%), Gaps = 41/283 (14%)
Query: 91 PPASIRGGGGGAEKATPL-------APKGAAPGAV----------QPVAGAEAAPAATLA 133
PP ++ GGGGG AP PG Q G +A+ A
Sbjct: 155 PPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSASAA 214
Query: 134 ALGGRRPGPPEEPPRELESVPSKLGEPPP----LGEGGGGGGEGGGAGGGSGEREGGAPQ 189
A G PG + E P+ P G GGGGGG GGG GGGSG GG
Sbjct: 215 AAGA--PGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGG-GGGGGGGSGGGGGGGGA 271
Query: 190 PPPPRGWRGKGVRAQQRGGSGGEGASPSPSSSSAGKTPGTGSRNSGSGVAGGGSGGGGSY 249
G A + G G SSAG + R G G+ G GGG +
Sbjct: 272 GAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAAS 331
Query: 250 WKE---GCLQSELIQFHLKKERAAAA--------AAAAQMHAKNGGGSSSRSSPVSGPPA 298
+ G +F + + + A + + M GG SSP + PP
Sbjct: 332 LSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPP 391
Query: 299 VCETLAVASASPMAAAAEGPQQSAEGSASG---GGMQAAAPPS 338
+ + A+A A AA G QQ+A G G G AAA P+
Sbjct: 392 PSQPQSQAAA---AGAAAGGQQAAAGMGLGKDMGAQYAAASPA 431
Score = 42.7 bits (99), Expect = 0.002
Identities = 101/432 (23%), Positives = 143/432 (33%), Gaps = 86/432 (19%)
Query: 3 QPPI----GGAAPATA--------AASPAAAATEARLHPEGSSRKQQRAQSPARPRDSSL 50
QPP+ GG PA +A+PA+ R P Q QSP +
Sbjct: 154 QPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQ--QSPG------M 205
Query: 51 RQTIAATRSPVGAGTKLNSVRQQQLQQQQQQGNKTGSRTGPPASIRGGGGGAEKA-TPLA 109
+A+ + GA ++ ++ Q N + P A GGGGG +
Sbjct: 206 GMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGG 265
Query: 110 PKGAAPGAVQPVAGAEAAPAATLAALGGRRPGPP---EEPPRELESVPSKLGEPPPLGEG 166
G GA AGA AA AA AA G G + S P + G +G G
Sbjct: 266 GGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPG 325
Query: 167 GGGGGE------GGGAGG-----GSGEREGGAPQPPPPRGWRGKGVRAQQRGGSGGEGAS 215
GGG G AGG G + GA P + + GGS E +S
Sbjct: 326 GGGAASLSKAAAGSAAGGFQRFAGQNQHPSGAT-PTLNQLLTSPSPMMRSYGGSYPEYSS 384
Query: 216 PS--------PSSSSAGKTPGTGSRNSGSGVAGGGSGGGGSY------WKEGCLQSELIQ 261
PS P S +A G + + +G+ G G G Y W +S
Sbjct: 385 PSAPPPPPSQPQSQAAAAGAAAGGQQAAAGM-GLGKDMGAQYAAASPAWAAAQQRSHPAM 443
Query: 262 FHLKKERAAAAAAAAQMHAK-------NGGGSSSRSSPVS---------GPPAVCE-TLA 304
+ + M G GS+ S P GPP +
Sbjct: 444 SPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIG 503
Query: 305 VASASPMAAAA------EGPQQSAEGSASGGGMQAAAP------------PSSQPHPQQL 346
+ +P A A + P Q + SG Q P P +Q P Q
Sbjct: 504 IQGRTPGAMAGMQYPQQQMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQS 563
Query: 347 QEQEEMQEEMEK 358
Q++ + Q++M +
Sbjct: 564 QQRYQPQQDMSQ 575
Score = 42.4 bits (98), Expect = 0.002
Identities = 83/364 (22%), Positives = 116/364 (31%), Gaps = 76/364 (20%)
Query: 14 AAASPAAAATEARLHPEGSSRKQQRAQSPARPRDSSLRQTIAATRSPVGAGTKLNSVRQQ 73
AAASPA AA + R HP A SP P + R + V +L +
Sbjct: 426 AAASPAWAAAQQRSHP---------AMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSN 476
Query: 74 QLQQQQQQGNKTGSRTGPPASIRGGGGGAEKATPLAPKGAAPGAVQPVAGAEAAPAATLA 133
Q QQ G GPP R P+ +G PGA+ + +
Sbjct: 477 PHSQPQQSSPYPGGSYGPPGPQR---------YPIGIQGRTPGAMAGMQYPQQQMPPQYG 527
Query: 134 ALG-------------GRRPGPPEEPPRE--LESVPSKLGEPPP--LGEGGGGGGEGGGA 176
G ++P PP PP+ L S + +P EG G + A
Sbjct: 528 QQGVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLA 587
Query: 177 GGGSG---------EREGGAPQ--------PPPPRGWRGKGVRAQQRGGSGGEGASPSPS 219
G ER P P V A S G+ ++P+ S
Sbjct: 588 PGKPNHEDLNLIQQERPSSLPDLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQS 647
Query: 220 SSSAGKTPGTGSRNSGSGVAGGGSGGGGSYWKEGCLQSELIQFHLKKERAAAAAAAAQMH 279
S +P S G + GS G + + G + + A+ +QM
Sbjct: 648 PFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPI-------------SPASIPGSQMP 694
Query: 280 AKNGGGSSSRSSPVSGPPAVCETLAVASASPMAAAAEGPQQSAEGSASGGGMQAAAPPSS 339
+ G S SS PA+ ++ MA PQ + G G PS
Sbjct: 695 PQPPGSQSESSS----HPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTG-------PSM 743
Query: 340 QPHP 343
PHP
Sbjct: 744 SPHP 747
Score = 30.4 bits (67), Expect = 8.2
Identities = 49/203 (24%), Positives = 73/203 (35%), Gaps = 33/203 (16%)
Query: 67 LNSVRQQQLQQQQQQGNKT-GSRTGPPASIRGGGGGAEKATPLAPKGAAP-----GAVQP 120
L S QQ+ Q QQ + G+R+ PP + G E + + + G++
Sbjct: 559 LPSQSQQRYQPQQDMSQEGYGTRSQPP--LAPGKPNHEDLNLIQQERPSSLPDLSGSIDD 616
Query: 121 V-AGAEAAPAATLAALG-----GRRPGPPEEP--PRELESVPSKLGEPPPLGEGGGGGGE 172
+ G EA ++ ++A G G + P + P P + S G P P G G
Sbjct: 617 LPTGTEATLSSAVSASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSN 676
Query: 173 GGGAGGGSGEREGGAPQPPPPRGWRGKGVRAQQRGGSGGEGASPSPSSSSAGKTPGT--- 229
+G S G+ PP P G Q S S SP G GT
Sbjct: 677 QSRSGPISPASIPGSQMPPQPPG--------SQSESSSHPALSQSPMPQERGFMAGTQRN 728
Query: 230 ------GSRNSGSGVAGGGSGGG 246
G + +G ++ S GG
Sbjct: 729 PQMAQYGPQQTGPSMSPHPSPGG 751
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 83.6 bits (205), Expect = 8e-16
Identities = 97/432 (22%), Positives = 193/432 (44%), Gaps = 48/432 (11%)
Query: 344 QQLQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERAN 403
+QLQ + E+ E E++R K E++E+ EM+ EE+ + Q+++ E ++
Sbjct: 894 EQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEAR----LEEEEDRGQQLQAERKKMA 949
Query: 404 KNCRILQYRLRKAERKRLRYAQTGEIDGEL-LRSLEQDLKVAKDVSVRLHHELENVEEK- 461
+ L+ +L + E R + Q ++ E ++ LE ++ V D + +L E + +EE+
Sbjct: 950 QQMLDLEEQLEEEEAARQKL-QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERI 1008
Query: 462 --RTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTE 519
TT E E+ + L +++ +++ +ELE + K R + K + + +
Sbjct: 1009 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1068
Query: 520 EDNEDLKCQLQFVKEEAALMRKKM----AKIDKEKDRFEHELQKYRSFYG-------DLD 568
E DL+ Q+ +K + A +++ A++D E + + L+K R G DLD
Sbjct: 1069 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1128
Query: 569 SPLP--------KGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEV-------ENR 613
S K + G + EL+ L + + ++ E+ V E R
Sbjct: 1129 SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1188
Query: 614 GLKAELDDLRGDDFNGSANPLMREQSESLSELRQHL----QLVEDET-------ELLRRN 662
+A++ ++R + A + EQ E + +L Q +E E +L +
Sbjct: 1189 SHEAQVQEMRQK--HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQA 1246
Query: 663 VADLEEQNKRITAELNKYKYKSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVMQL 722
++E + K++ A++ + + K + AR N K LQ E+++ +NE GK ++L
Sbjct: 1247 KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKL 1306
Query: 723 QYENRVLMSNMQ 734
+ L S +Q
Sbjct: 1307 AKDVASLSSQLQ 1318
Score = 66.2 bits (160), Expect = 1e-10
Identities = 109/471 (23%), Positives = 190/471 (40%), Gaps = 85/471 (18%)
Query: 331 MQAAAPPSSQPHPQQLQEQEEMQEE-MEKLREENETLKNEIDELRTEMDEMRDTFFEEDA 389
++ A ++ H Q+QE + + +E+L E+ E K + +D+ + T +E+A
Sbjct: 1179 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA----KANLDKNKQTLEKENA 1234
Query: 390 CQL----------QEMRHELERANKNCRILQYRLRKAERKRLRYA--------QTGEIDG 431
QE+ H+ ++ + LQ + ER R + + G
Sbjct: 1235 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1294
Query: 432 ELLRSLEQDLKVAKDVSVRLHHELE--------------NVEEKRTTTEDENEKLRQQLI 477
L + + +K+AKDV+ L +L+ NV K E+E L+ QL
Sbjct: 1295 MLNEAEGKAIKLAKDVA-SLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLD 1353
Query: 478 EVEIAKQALQNEL-----------EKMKELSL--------KRRGSKDLPK-----SEKKA 513
E AKQ L+ + +K+++ + K+R K++ EK A
Sbjct: 1354 EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAA 1413
Query: 514 QQTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPK 573
E+ L+ +L + + R+ ++ ++K++ +F+ L + ++ +
Sbjct: 1414 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1473
Query: 574 GEAGGPPSTREAELK-LRLRLVEEEANILGRKIVELEVENRGLKAELDDL--RGDDFNGS 630
EA RE E K L L EEA L K ELE N+ LKAE++DL DD +
Sbjct: 1474 AEA----EAREKETKALSLARALEEA--LEAK-EELERTNKMLKAEMEDLVSSKDDVGKN 1526
Query: 631 ANPL----------MREQSESLSELRQHLQLVEDETELLRRNVADLE---EQNKRITAEL 677
+ L M E L EL LQ ED L N+ L+ E++ + E
Sbjct: 1527 VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ 1586
Query: 678 NKYKYKSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVMQLQYENRV 728
N+ K + + + E Q L AA + E K ++LQ ++ +
Sbjct: 1587 NEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1637
Score = 58.9 bits (141), Expect = 2e-08
Identities = 79/338 (23%), Positives = 141/338 (41%), Gaps = 59/338 (17%)
Query: 346 LQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDT---------FFEEDACQLQEMR 396
++ +EE +++ KL+ + + + E+++ R DE+ T E D QLQE
Sbjct: 1637 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1696
Query: 397 HELERANKNCRI------------LQYRLRKAERKRLRYAQTGEIDGEL------LRSLE 438
ERA K + L R + KR A+ +++ EL + ++
Sbjct: 1697 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1756
Query: 439 QDLKVAKDVSVRLHHEL-------ENVEEKRTTTEDENEKLRQQLIEVE----------- 480
++ A + +L +EL + E R E +N++LR +L E+E
Sbjct: 1757 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1816
Query: 481 --IAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTEEDNEDLKCQLQFVKEEAAL 538
+ + Q E + +E K+ +K L + +KK ++ + ED + + KE+A
Sbjct: 1817 AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQV--EDERKMAEQYKEQAEK 1874
Query: 539 MRKKMAKIDKEKDRFEHELQKY----RSFYGDLDSPLPKGEAGGPPSTREAE-LKLRLRL 593
++ ++ ++ + E E Q+ R +LD EA G RE LK +LR
Sbjct: 1875 GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMG----REVNALKSKLRR 1930
Query: 594 VEEEANILGRKIVELEV-ENRGLKAELDDLRGDDFNGS 630
E + + R+ V EN E D R DFNG+
Sbjct: 1931 GNETSFVPSRRSGGRRVIENADGSEEETDTRDADFNGT 1968
Score = 58.5 bits (140), Expect = 3e-08
Identities = 91/421 (21%), Positives = 165/421 (39%), Gaps = 51/421 (12%)
Query: 347 QEQEEMQEEMEKLREENETLKNEIDELRTEMDEMR-------------DTFFEEDACQLQ 393
Q+ EE +KL + L+ E+D+L ++D R D E+
Sbjct: 1406 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1465
Query: 394 EMRHELERANKNCRILQYR---LRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVR 450
+ E +RA R + + L +A + L + E ++L++ +DL +KD +
Sbjct: 1466 KYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGK 1525
Query: 451 LHHELENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSE 510
HELE + + E + E+++ QL E+E +EL+ ++ L+ + K +
Sbjct: 1526 NVHELE---KSKRALETQMEEMKTQLEELE-------DELQATEDAKLRLEVNMQALKGQ 1575
Query: 511 KKAQQTPTEEDNEDLKCQLQ----FVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGD 566
+ +E NE+ + QLQ + E RK+ A K + E +L+
Sbjct: 1576 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL---Q 1632
Query: 567 LDSPLPKGEAGGPPSTREAELKLR-LRLVEEEANILGRKIVELEVEN----RGLKAELDD 621
DS + KG R+ + +++ + E+A +I EN + L+A+L
Sbjct: 1633 ADSAI-KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1691
Query: 622 LRGD-----DFNGSANPLMREQSESLSELRQHLQLVEDETELLRRNVADLEEQNKRITAE 676
L+ D A+ E +E L+ ++DE L +A LEE E
Sbjct: 1692 LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEE-------E 1744
Query: 677 LNKYKYKSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVMQLQYENRVLMSNMQRY 736
L + + + E L EL R + QL+ +N+ L S +
Sbjct: 1745 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM 1804
Query: 737 D 737
+
Sbjct: 1805 E 1805
Score = 57.8 bits (138), Expect = 5e-08
Identities = 76/370 (20%), Positives = 152/370 (41%), Gaps = 50/370 (13%)
Query: 347 QEQEEMQEEMEKLREENETLKNEIDELRTEMDE------------------MRDTFFEED 388
Q + ++Q E+ E+ L+ ++ E TE+++ ++D + D
Sbjct: 1575 QFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1634
Query: 389 AC--QLQEMRHELERANKNCRILQYRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKD 446
+ +E +L + + Q L A R T + + + +SLE DL
Sbjct: 1635 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL----- 1689
Query: 447 VSVRLHHELENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMK--------ELSL 498
++L +L E R + E E+L ++L + ALQ+E +++ EL
Sbjct: 1690 --MQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE 1747
Query: 499 KRRGSKDLPKSEKKAQQTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQ 558
++ + + +KA Q + NE + K E+A R+++ + +KE HE++
Sbjct: 1748 EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA--RQQLERQNKELRSKLHEME 1805
Query: 559 -----KYRSFYGDLDSPLPKGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENR 613
K++S L++ + + E RE + + L +++ + K + L+VE+
Sbjct: 1806 GAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK-SLKQKDKKL---KEILLQVEDE 1861
Query: 614 GLKAELDDLRGDDFNGSANPLMREQSESLSELRQHLQLVEDETELLRRNVADLEEQNKRI 673
AE + + N L R+ L E + Q + L+R + + E N+ +
Sbjct: 1862 RKMAEQYKEQAEKGNARVKQLKRQ----LEEAEEESQRINANRRKLQRELDEATESNEAM 1917
Query: 674 TAELNKYKYK 683
E+N K K
Sbjct: 1918 GREVNALKSK 1927
Score = 57.0 bits (136), Expect = 8e-08
Identities = 121/584 (20%), Positives = 231/584 (39%), Gaps = 87/584 (14%)
Query: 391 QLQEMRHELERANKNCRILQYRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVR 450
++Q EL++ + + + L++ E+K + + + E L++ + A+++ VR
Sbjct: 853 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 912
Query: 451 LH----------HE----LENVEEKRTTTEDENEKLRQQLI-------EVEIAKQALQ-- 487
L HE LE E++ + E +K+ QQ++ E E A+Q LQ
Sbjct: 913 LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE 972
Query: 488 ----------------------NELEKMKELSLKRRG--SKDLPKSEKKAQQ-TPTEEDN 522
N+L K ++L +R + +L + E+KA+ T + +
Sbjct: 973 KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1032
Query: 523 EDLKCQLQF-VKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGEAGGPPS 581
E + +L+ +K+E K +++K K + E + + DL + + E +
Sbjct: 1033 ESMISELEVRLKKE----EKSRQELEKLKRKLEGDASDFHEQIADLQAQI--AELKMQLA 1086
Query: 582 TREAELKLRLRLVEEE---ANILGRKIVELEVENRGLKAELDDLRGDDFNGSANPLMREQ 638
+E EL+ L +++E N +KI ELE L+ +LD R A R+
Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA--ARNKAEKQKRDL 1144
Query: 639 SESLSELRQHLQLVEDETELLRRNVADLEEQNKRITAELNKYKYKSGGHDSARHHDNAKT 698
E L L+ L+ D T +Q R E K + R H+
Sbjct: 1145 GEELEALKTELEDTLDST---------ATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1195
Query: 699 EALQEELKAARLQINELSGKVMQLQYENRVLMSNMQ-----RYDLASHLGIRGSPRDSDA 753
E Q+ +A + EL+ ++ Q + L N Q DLA L + G +
Sbjct: 1196 EMRQKHAQA----VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ--- 1248
Query: 754 ESDAGKKESDDDSRPPHRK-REGPIGGESDSEEVRNIR--CLTPTRSFYPAPGPWPKSFS 810
E + KK+ + + K +G +++V ++ + T A G K
Sbjct: 1249 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1308
Query: 811 DRQQMKDIRSEAERLGKTIDRLIADTSTIITEARIYVANGDLFGLMDEEDDGSRIREHEL 870
D + + + L + R + ST + + + L +DEE + + E
Sbjct: 1309 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQ--LEEERNSLQDQLDEEMEAKQNLERH- 1365
Query: 871 LYRINAQMKAFRKELQTFIDRLEVPKSADDRGAEEPISVSQMFQ 914
+ +N Q+ +K+LQ F +E + R +E +++Q ++
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1409
Score = 52.0 bits (123), Expect = 3e-06
Identities = 65/257 (25%), Positives = 125/257 (48%), Gaps = 34/257 (13%)
Query: 459 EEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPT 518
EE+ EDE +K +++ +Q +NEL+++++ + K+L + + +A +T
Sbjct: 851 EEEMQAKEDELQKTKER-------QQKAENELKELEQKHSQLTEEKNLLQEQLQA-ETEL 902
Query: 519 EEDNEDLKCQLQFVKEE-AALMRKKMAKIDKEKDR---FEHELQKYRSFYGDLDSPLPKG 574
+ E+++ +L K+E ++ + A++++E+DR + E +K DL+ L +
Sbjct: 903 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 962
Query: 575 EAGGPPSTREAELKLRLRLVEEEANI--LGRKIVELEVENRGLKAE---LDDLRGDDFNG 629
EA A KL+L V EA I L +I+ ++ +N L E L++ D
Sbjct: 963 EA--------ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1014
Query: 630 SANPLMREQSESLSELRQHLQLVEDETELLRRNVADLEEQNKRITAELNKYKYKSGGHDS 689
A E++++L++L+ + + E E+ + EE++++ EL K K K G S
Sbjct: 1015 LAEE--EEKAKNLTKLKNKHESMISELEVRLKK----EEKSRQ---ELEKLKRKLEGDAS 1065
Query: 690 ARHHDNAKTEALQEELK 706
H A +A ELK
Sbjct: 1066 DFHEQIADLQAQIAELK 1082
Score = 43.9 bits (102), Expect = 7e-04
Identities = 63/288 (21%), Positives = 117/288 (40%), Gaps = 42/288 (14%)
Query: 255 LQSELIQFHLKKERAAAAAAAAQMHAKNGGGSSSRSSPVSGPPAVCETLAVASASPMAAA 314
LQ+++ F ++E A A+ ++ A S + + E LA A + A
Sbjct: 1650 LQAQMKDF--QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1707
Query: 315 AEGPQQSAEGSASGGGMQAAAPPSSQPHPQQLQEQEEMQEE----------MEKLREENE 364
E + + E ++S G A + + Q +EE++EE + K ++ E
Sbjct: 1708 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1767
Query: 365 TLKNEIDELRT--EMDEMRDTFFEEDACQLQEMRHELERANKN----------CRILQYR 412
L NE+ R+ + +E E +L+ HE+E A K+ +I Q
Sbjct: 1768 QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE 1827
Query: 413 LRKAERKRLRYAQTGEIDG------ELLRSLEQDLKVAKDVSVR----------LHHELE 456
+ + R + A T + E+L +E + K+A+ + L +LE
Sbjct: 1828 EQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLE 1887
Query: 457 NVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSK 504
EE+ KL+++L E + +A+ E+ +K S RRG++
Sbjct: 1888 EAEEESQRINANRRKLQRELDEATESNEAMGREVNALK--SKLRRGNE 1933
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 83.6 bits (205), Expect = 8e-16
Identities = 97/432 (22%), Positives = 193/432 (44%), Gaps = 48/432 (11%)
Query: 344 QQLQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERAN 403
+QLQ + E+ E E++R K E++E+ EM+ EE+ + Q+++ E ++
Sbjct: 901 EQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEAR----LEEEEDRGQQLQAERKKMA 956
Query: 404 KNCRILQYRLRKAERKRLRYAQTGEIDGEL-LRSLEQDLKVAKDVSVRLHHELENVEEK- 461
+ L+ +L + E R + Q ++ E ++ LE ++ V D + +L E + +EE+
Sbjct: 957 QQMLDLEEQLEEEEAARQKL-QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERI 1015
Query: 462 --RTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTE 519
TT E E+ + L +++ +++ +ELE + K R + K + + +
Sbjct: 1016 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1075
Query: 520 EDNEDLKCQLQFVKEEAALMRKKM----AKIDKEKDRFEHELQKYRSFYG-------DLD 568
E DL+ Q+ +K + A +++ A++D E + + L+K R G DLD
Sbjct: 1076 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1135
Query: 569 SPLP--------KGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEV-------ENR 613
S K + G + EL+ L + + ++ E+ V E R
Sbjct: 1136 SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1195
Query: 614 GLKAELDDLRGDDFNGSANPLMREQSESLSELRQHL----QLVEDET-------ELLRRN 662
+A++ ++R + A + EQ E + +L Q +E E +L +
Sbjct: 1196 SHEAQVQEMRQK--HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQA 1253
Query: 663 VADLEEQNKRITAELNKYKYKSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVMQL 722
++E + K++ A++ + + K + AR N K LQ E+++ +NE GK ++L
Sbjct: 1254 KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKL 1313
Query: 723 QYENRVLMSNMQ 734
+ L S +Q
Sbjct: 1314 AKDVASLSSQLQ 1325
Score = 66.2 bits (160), Expect = 1e-10
Identities = 109/471 (23%), Positives = 190/471 (40%), Gaps = 85/471 (18%)
Query: 331 MQAAAPPSSQPHPQQLQEQEEMQEE-MEKLREENETLKNEIDELRTEMDEMRDTFFEEDA 389
++ A ++ H Q+QE + + +E+L E+ E K + +D+ + T +E+A
Sbjct: 1186 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA----KANLDKNKQTLEKENA 1241
Query: 390 CQL----------QEMRHELERANKNCRILQYRLRKAERKRLRYA--------QTGEIDG 431
QE+ H+ ++ + LQ + ER R + + G
Sbjct: 1242 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1301
Query: 432 ELLRSLEQDLKVAKDVSVRLHHELE--------------NVEEKRTTTEDENEKLRQQLI 477
L + + +K+AKDV+ L +L+ NV K E+E L+ QL
Sbjct: 1302 MLNEAEGKAIKLAKDVA-SLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLD 1360
Query: 478 EVEIAKQALQNEL-----------EKMKELSL--------KRRGSKDLPK-----SEKKA 513
E AKQ L+ + +K+++ + K+R K++ EK A
Sbjct: 1361 EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAA 1420
Query: 514 QQTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPK 573
E+ L+ +L + + R+ ++ ++K++ +F+ L + ++ +
Sbjct: 1421 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1480
Query: 574 GEAGGPPSTREAELK-LRLRLVEEEANILGRKIVELEVENRGLKAELDDL--RGDDFNGS 630
EA RE E K L L EEA L K ELE N+ LKAE++DL DD +
Sbjct: 1481 AEA----EAREKETKALSLARALEEA--LEAK-EELERTNKMLKAEMEDLVSSKDDVGKN 1533
Query: 631 ANPL----------MREQSESLSELRQHLQLVEDETELLRRNVADLE---EQNKRITAEL 677
+ L M E L EL LQ ED L N+ L+ E++ + E
Sbjct: 1534 VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ 1593
Query: 678 NKYKYKSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVMQLQYENRV 728
N+ K + + + E Q L AA + E K ++LQ ++ +
Sbjct: 1594 NEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1644
Score = 58.9 bits (141), Expect = 2e-08
Identities = 79/338 (23%), Positives = 141/338 (41%), Gaps = 59/338 (17%)
Query: 346 LQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDT---------FFEEDACQLQEMR 396
++ +EE +++ KL+ + + + E+++ R DE+ T E D QLQE
Sbjct: 1644 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1703
Query: 397 HELERANKNCRI------------LQYRLRKAERKRLRYAQTGEIDGEL------LRSLE 438
ERA K + L R + KR A+ +++ EL + ++
Sbjct: 1704 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1763
Query: 439 QDLKVAKDVSVRLHHEL-------ENVEEKRTTTEDENEKLRQQLIEVE----------- 480
++ A + +L +EL + E R E +N++LR +L E+E
Sbjct: 1764 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1823
Query: 481 --IAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTEEDNEDLKCQLQFVKEEAAL 538
+ + Q E + +E K+ +K L + +KK ++ + ED + + KE+A
Sbjct: 1824 AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQV--EDERKMAEQYKEQAEK 1881
Query: 539 MRKKMAKIDKEKDRFEHELQKY----RSFYGDLDSPLPKGEAGGPPSTREAE-LKLRLRL 593
++ ++ ++ + E E Q+ R +LD EA G RE LK +LR
Sbjct: 1882 GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMG----REVNALKSKLRR 1937
Query: 594 VEEEANILGRKIVELEV-ENRGLKAELDDLRGDDFNGS 630
E + + R+ V EN E D R DFNG+
Sbjct: 1938 GNETSFVPSRRSGGRRVIENADGSEEETDTRDADFNGT 1975
Score = 58.5 bits (140), Expect = 3e-08
Identities = 91/421 (21%), Positives = 165/421 (39%), Gaps = 51/421 (12%)
Query: 347 QEQEEMQEEMEKLREENETLKNEIDELRTEMDEMR-------------DTFFEEDACQLQ 393
Q+ EE +KL + L+ E+D+L ++D R D E+
Sbjct: 1413 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1472
Query: 394 EMRHELERANKNCRILQYR---LRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVR 450
+ E +RA R + + L +A + L + E ++L++ +DL +KD +
Sbjct: 1473 KYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGK 1532
Query: 451 LHHELENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSE 510
HELE + + E + E+++ QL E+E +EL+ ++ L+ + K +
Sbjct: 1533 NVHELE---KSKRALETQMEEMKTQLEELE-------DELQATEDAKLRLEVNMQALKGQ 1582
Query: 511 KKAQQTPTEEDNEDLKCQLQ----FVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGD 566
+ +E NE+ + QLQ + E RK+ A K + E +L+
Sbjct: 1583 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL---Q 1639
Query: 567 LDSPLPKGEAGGPPSTREAELKLR-LRLVEEEANILGRKIVELEVEN----RGLKAELDD 621
DS + KG R+ + +++ + E+A +I EN + L+A+L
Sbjct: 1640 ADSAI-KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1698
Query: 622 LRGD-----DFNGSANPLMREQSESLSELRQHLQLVEDETELLRRNVADLEEQNKRITAE 676
L+ D A+ E +E L+ ++DE L +A LEE E
Sbjct: 1699 LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEE-------E 1751
Query: 677 LNKYKYKSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVMQLQYENRVLMSNMQRY 736
L + + + E L EL R + QL+ +N+ L S +
Sbjct: 1752 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM 1811
Query: 737 D 737
+
Sbjct: 1812 E 1812
Score = 57.8 bits (138), Expect = 5e-08
Identities = 76/370 (20%), Positives = 152/370 (41%), Gaps = 50/370 (13%)
Query: 347 QEQEEMQEEMEKLREENETLKNEIDELRTEMDE------------------MRDTFFEED 388
Q + ++Q E+ E+ L+ ++ E TE+++ ++D + D
Sbjct: 1582 QFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1641
Query: 389 AC--QLQEMRHELERANKNCRILQYRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKD 446
+ +E +L + + Q L A R T + + + +SLE DL
Sbjct: 1642 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL----- 1696
Query: 447 VSVRLHHELENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMK--------ELSL 498
++L +L E R + E E+L ++L + ALQ+E +++ EL
Sbjct: 1697 --MQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE 1754
Query: 499 KRRGSKDLPKSEKKAQQTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQ 558
++ + + +KA Q + NE + K E+A R+++ + +KE HE++
Sbjct: 1755 EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA--RQQLERQNKELRSKLHEME 1812
Query: 559 -----KYRSFYGDLDSPLPKGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENR 613
K++S L++ + + E RE + + L +++ + K + L+VE+
Sbjct: 1813 GAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK-SLKQKDKKL---KEILLQVEDE 1868
Query: 614 GLKAELDDLRGDDFNGSANPLMREQSESLSELRQHLQLVEDETELLRRNVADLEEQNKRI 673
AE + + N L R+ L E + Q + L+R + + E N+ +
Sbjct: 1869 RKMAEQYKEQAEKGNARVKQLKRQ----LEEAEEESQRINANRRKLQRELDEATESNEAM 1924
Query: 674 TAELNKYKYK 683
E+N K K
Sbjct: 1925 GREVNALKSK 1934
Score = 57.0 bits (136), Expect = 8e-08
Identities = 121/584 (20%), Positives = 231/584 (39%), Gaps = 87/584 (14%)
Query: 391 QLQEMRHELERANKNCRILQYRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVR 450
++Q EL++ + + + L++ E+K + + + E L++ + A+++ VR
Sbjct: 860 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 919
Query: 451 LH----------HE----LENVEEKRTTTEDENEKLRQQLI-------EVEIAKQALQ-- 487
L HE LE E++ + E +K+ QQ++ E E A+Q LQ
Sbjct: 920 LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE 979
Query: 488 ----------------------NELEKMKELSLKRRG--SKDLPKSEKKAQQ-TPTEEDN 522
N+L K ++L +R + +L + E+KA+ T + +
Sbjct: 980 KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1039
Query: 523 EDLKCQLQF-VKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGEAGGPPS 581
E + +L+ +K+E K +++K K + E + + DL + + E +
Sbjct: 1040 ESMISELEVRLKKE----EKSRQELEKLKRKLEGDASDFHEQIADLQAQI--AELKMQLA 1093
Query: 582 TREAELKLRLRLVEEE---ANILGRKIVELEVENRGLKAELDDLRGDDFNGSANPLMREQ 638
+E EL+ L +++E N +KI ELE L+ +LD R A R+
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA--ARNKAEKQKRDL 1151
Query: 639 SESLSELRQHLQLVEDETELLRRNVADLEEQNKRITAELNKYKYKSGGHDSARHHDNAKT 698
E L L+ L+ D T +Q R E K + R H+
Sbjct: 1152 GEELEALKTELEDTLDST---------ATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1202
Query: 699 EALQEELKAARLQINELSGKVMQLQYENRVLMSNMQ-----RYDLASHLGIRGSPRDSDA 753
E Q+ +A + EL+ ++ Q + L N Q DLA L + G +
Sbjct: 1203 EMRQKHAQA----VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ--- 1255
Query: 754 ESDAGKKESDDDSRPPHRK-REGPIGGESDSEEVRNIR--CLTPTRSFYPAPGPWPKSFS 810
E + KK+ + + K +G +++V ++ + T A G K
Sbjct: 1256 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1315
Query: 811 DRQQMKDIRSEAERLGKTIDRLIADTSTIITEARIYVANGDLFGLMDEEDDGSRIREHEL 870
D + + + L + R + ST + + + L +DEE + + E
Sbjct: 1316 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQ--LEEERNSLQDQLDEEMEAKQNLERH- 1372
Query: 871 LYRINAQMKAFRKELQTFIDRLEVPKSADDRGAEEPISVSQMFQ 914
+ +N Q+ +K+LQ F +E + R +E +++Q ++
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1416
Score = 52.0 bits (123), Expect = 3e-06
Identities = 65/257 (25%), Positives = 125/257 (48%), Gaps = 34/257 (13%)
Query: 459 EEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPT 518
EE+ EDE +K +++ +Q +NEL+++++ + K+L + + +A +T
Sbjct: 858 EEEMQAKEDELQKTKER-------QQKAENELKELEQKHSQLTEEKNLLQEQLQA-ETEL 909
Query: 519 EEDNEDLKCQLQFVKEE-AALMRKKMAKIDKEKDR---FEHELQKYRSFYGDLDSPLPKG 574
+ E+++ +L K+E ++ + A++++E+DR + E +K DL+ L +
Sbjct: 910 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 969
Query: 575 EAGGPPSTREAELKLRLRLVEEEANI--LGRKIVELEVENRGLKAE---LDDLRGDDFNG 629
EA A KL+L V EA I L +I+ ++ +N L E L++ D
Sbjct: 970 EA--------ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1021
Query: 630 SANPLMREQSESLSELRQHLQLVEDETELLRRNVADLEEQNKRITAELNKYKYKSGGHDS 689
A E++++L++L+ + + E E+ + EE++++ EL K K K G S
Sbjct: 1022 LAEE--EEKAKNLTKLKNKHESMISELEVRLKK----EEKSRQ---ELEKLKRKLEGDAS 1072
Query: 690 ARHHDNAKTEALQEELK 706
H A +A ELK
Sbjct: 1073 DFHEQIADLQAQIAELK 1089
Score = 43.9 bits (102), Expect = 7e-04
Identities = 63/288 (21%), Positives = 117/288 (40%), Gaps = 42/288 (14%)
Query: 255 LQSELIQFHLKKERAAAAAAAAQMHAKNGGGSSSRSSPVSGPPAVCETLAVASASPMAAA 314
LQ+++ F ++E A A+ ++ A S + + E LA A + A
Sbjct: 1657 LQAQMKDF--QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1714
Query: 315 AEGPQQSAEGSASGGGMQAAAPPSSQPHPQQLQEQEEMQEE----------MEKLREENE 364
E + + E ++S G A + + Q +EE++EE + K ++ E
Sbjct: 1715 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1774
Query: 365 TLKNEIDELRT--EMDEMRDTFFEEDACQLQEMRHELERANKN----------CRILQYR 412
L NE+ R+ + +E E +L+ HE+E A K+ +I Q
Sbjct: 1775 QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE 1834
Query: 413 LRKAERKRLRYAQTGEIDG------ELLRSLEQDLKVAKDVSVR----------LHHELE 456
+ + R + A T + E+L +E + K+A+ + L +LE
Sbjct: 1835 EQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLE 1894
Query: 457 NVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSK 504
EE+ KL+++L E + +A+ E+ +K S RRG++
Sbjct: 1895 EAEEESQRINANRRKLQRELDEATESNEAMGREVNALK--SKLRRGNE 1940
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 83.6 bits (205), Expect = 8e-16
Identities = 97/432 (22%), Positives = 193/432 (44%), Gaps = 48/432 (11%)
Query: 344 QQLQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERAN 403
+QLQ + E+ E E++R K E++E+ EM+ EE+ + Q+++ E ++
Sbjct: 901 EQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEAR----LEEEEDRGQQLQAERKKMA 956
Query: 404 KNCRILQYRLRKAERKRLRYAQTGEIDGEL-LRSLEQDLKVAKDVSVRLHHELENVEEK- 461
+ L+ +L + E R + Q ++ E ++ LE ++ V D + +L E + +EE+
Sbjct: 957 QQMLDLEEQLEEEEAARQKL-QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERI 1015
Query: 462 --RTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTE 519
TT E E+ + L +++ +++ +ELE + K R + K + + +
Sbjct: 1016 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1075
Query: 520 EDNEDLKCQLQFVKEEAALMRKKM----AKIDKEKDRFEHELQKYRSFYG-------DLD 568
E DL+ Q+ +K + A +++ A++D E + + L+K R G DLD
Sbjct: 1076 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1135
Query: 569 SPLP--------KGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEV-------ENR 613
S K + G + EL+ L + + ++ E+ V E R
Sbjct: 1136 SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1195
Query: 614 GLKAELDDLRGDDFNGSANPLMREQSESLSELRQHL----QLVEDET-------ELLRRN 662
+A++ ++R + A + EQ E + +L Q +E E +L +
Sbjct: 1196 SHEAQVQEMRQK--HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQA 1253
Query: 663 VADLEEQNKRITAELNKYKYKSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVMQL 722
++E + K++ A++ + + K + AR N K LQ E+++ +NE GK ++L
Sbjct: 1254 KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKL 1313
Query: 723 QYENRVLMSNMQ 734
+ L S +Q
Sbjct: 1314 AKDVASLSSQLQ 1325
Score = 66.2 bits (160), Expect = 1e-10
Identities = 109/471 (23%), Positives = 190/471 (40%), Gaps = 85/471 (18%)
Query: 331 MQAAAPPSSQPHPQQLQEQEEMQEE-MEKLREENETLKNEIDELRTEMDEMRDTFFEEDA 389
++ A ++ H Q+QE + + +E+L E+ E K + +D+ + T +E+A
Sbjct: 1186 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA----KANLDKNKQTLEKENA 1241
Query: 390 CQL----------QEMRHELERANKNCRILQYRLRKAERKRLRYA--------QTGEIDG 431
QE+ H+ ++ + LQ + ER R + + G
Sbjct: 1242 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1301
Query: 432 ELLRSLEQDLKVAKDVSVRLHHELE--------------NVEEKRTTTEDENEKLRQQLI 477
L + + +K+AKDV+ L +L+ NV K E+E L+ QL
Sbjct: 1302 MLNEAEGKAIKLAKDVA-SLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLD 1360
Query: 478 EVEIAKQALQNEL-----------EKMKELSL--------KRRGSKDLPK-----SEKKA 513
E AKQ L+ + +K+++ + K+R K++ EK A
Sbjct: 1361 EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAA 1420
Query: 514 QQTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPK 573
E+ L+ +L + + R+ ++ ++K++ +F+ L + ++ +
Sbjct: 1421 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1480
Query: 574 GEAGGPPSTREAELK-LRLRLVEEEANILGRKIVELEVENRGLKAELDDL--RGDDFNGS 630
EA RE E K L L EEA L K ELE N+ LKAE++DL DD +
Sbjct: 1481 AEA----EAREKETKALSLARALEEA--LEAK-EELERTNKMLKAEMEDLVSSKDDVGKN 1533
Query: 631 ANPL----------MREQSESLSELRQHLQLVEDETELLRRNVADLE---EQNKRITAEL 677
+ L M E L EL LQ ED L N+ L+ E++ + E
Sbjct: 1534 VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ 1593
Query: 678 NKYKYKSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVMQLQYENRV 728
N+ K + + + E Q L AA + E K ++LQ ++ +
Sbjct: 1594 NEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1644
Score = 58.5 bits (140), Expect = 3e-08
Identities = 91/421 (21%), Positives = 165/421 (39%), Gaps = 51/421 (12%)
Query: 347 QEQEEMQEEMEKLREENETLKNEIDELRTEMDEMR-------------DTFFEEDACQLQ 393
Q+ EE +KL + L+ E+D+L ++D R D E+
Sbjct: 1413 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1472
Query: 394 EMRHELERANKNCRILQYR---LRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVR 450
+ E +RA R + + L +A + L + E ++L++ +DL +KD +
Sbjct: 1473 KYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGK 1532
Query: 451 LHHELENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSE 510
HELE + + E + E+++ QL E+E +EL+ ++ L+ + K +
Sbjct: 1533 NVHELE---KSKRALETQMEEMKTQLEELE-------DELQATEDAKLRLEVNMQALKGQ 1582
Query: 511 KKAQQTPTEEDNEDLKCQLQ----FVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGD 566
+ +E NE+ + QLQ + E RK+ A K + E +L+
Sbjct: 1583 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL---Q 1639
Query: 567 LDSPLPKGEAGGPPSTREAELKLR-LRLVEEEANILGRKIVELEVEN----RGLKAELDD 621
DS + KG R+ + +++ + E+A +I EN + L+A+L
Sbjct: 1640 ADSAI-KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1698
Query: 622 LRGD-----DFNGSANPLMREQSESLSELRQHLQLVEDETELLRRNVADLEEQNKRITAE 676
L+ D A+ E +E L+ ++DE L +A LEE E
Sbjct: 1699 LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEE-------E 1751
Query: 677 LNKYKYKSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVMQLQYENRVLMSNMQRY 736
L + + + E L EL R + QL+ +N+ L S +
Sbjct: 1752 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM 1811
Query: 737 D 737
+
Sbjct: 1812 E 1812
Score = 58.5 bits (140), Expect = 3e-08
Identities = 77/373 (20%), Positives = 153/373 (41%), Gaps = 50/373 (13%)
Query: 347 QEQEEMQEEMEKLREENETLKNEIDELRTEMDE------------------MRDTFFEED 388
Q + ++Q E+ E+ L+ ++ E TE+++ ++D + D
Sbjct: 1582 QFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1641
Query: 389 AC--QLQEMRHELERANKNCRILQYRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKD 446
+ +E +L + + Q L A R T + + + +SLE DL
Sbjct: 1642 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL----- 1696
Query: 447 VSVRLHHELENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMK--------ELSL 498
++L +L E R + E E+L ++L + ALQ+E +++ EL
Sbjct: 1697 --MQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE 1754
Query: 499 KRRGSKDLPKSEKKAQQTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQ 558
++ + + +KA Q + NE + K E+A R+++ + +KE HE++
Sbjct: 1755 EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA--RQQLERQNKELRSKLHEME 1812
Query: 559 -----KYRSFYGDLDSPLPKGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENR 613
K++S L++ + + E RE + + L +++ + K + L+VE+
Sbjct: 1813 GAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK-SLKQKDKKL---KEILLQVEDE 1868
Query: 614 GLKAELDDLRGDDFNGSANPLMREQSESLSELRQHLQLVEDETELLRRNVADLEEQNKRI 673
AE + + N L R+ L E + Q + L+R + + E N+ +
Sbjct: 1869 RKMAEQYKEQAEKGNARVKQLKRQ----LEEAEEESQRINANRRKLQRELDEATESNEAM 1924
Query: 674 TAELNKYKYKSGG 686
E+N K K G
Sbjct: 1925 GREVNALKSKLRG 1937
Score = 57.0 bits (136), Expect = 8e-08
Identities = 121/584 (20%), Positives = 231/584 (39%), Gaps = 87/584 (14%)
Query: 391 QLQEMRHELERANKNCRILQYRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVR 450
++Q EL++ + + + L++ E+K + + + E L++ + A+++ VR
Sbjct: 860 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 919
Query: 451 LH----------HE----LENVEEKRTTTEDENEKLRQQLI-------EVEIAKQALQ-- 487
L HE LE E++ + E +K+ QQ++ E E A+Q LQ
Sbjct: 920 LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE 979
Query: 488 ----------------------NELEKMKELSLKRRG--SKDLPKSEKKAQQ-TPTEEDN 522
N+L K ++L +R + +L + E+KA+ T + +
Sbjct: 980 KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1039
Query: 523 EDLKCQLQF-VKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGEAGGPPS 581
E + +L+ +K+E K +++K K + E + + DL + + E +
Sbjct: 1040 ESMISELEVRLKKE----EKSRQELEKLKRKLEGDASDFHEQIADLQAQI--AELKMQLA 1093
Query: 582 TREAELKLRLRLVEEE---ANILGRKIVELEVENRGLKAELDDLRGDDFNGSANPLMREQ 638
+E EL+ L +++E N +KI ELE L+ +LD R A R+
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA--ARNKAEKQKRDL 1151
Query: 639 SESLSELRQHLQLVEDETELLRRNVADLEEQNKRITAELNKYKYKSGGHDSARHHDNAKT 698
E L L+ L+ D T +Q R E K + R H+
Sbjct: 1152 GEELEALKTELEDTLDST---------ATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1202
Query: 699 EALQEELKAARLQINELSGKVMQLQYENRVLMSNMQ-----RYDLASHLGIRGSPRDSDA 753
E Q+ +A + EL+ ++ Q + L N Q DLA L + G +
Sbjct: 1203 EMRQKHAQA----VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ--- 1255
Query: 754 ESDAGKKESDDDSRPPHRK-REGPIGGESDSEEVRNIR--CLTPTRSFYPAPGPWPKSFS 810
E + KK+ + + K +G +++V ++ + T A G K
Sbjct: 1256 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1315
Query: 811 DRQQMKDIRSEAERLGKTIDRLIADTSTIITEARIYVANGDLFGLMDEEDDGSRIREHEL 870
D + + + L + R + ST + + + L +DEE + + E
Sbjct: 1316 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQ--LEEERNSLQDQLDEEMEAKQNLERH- 1372
Query: 871 LYRINAQMKAFRKELQTFIDRLEVPKSADDRGAEEPISVSQMFQ 914
+ +N Q+ +K+LQ F +E + R +E +++Q ++
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1416
Score = 52.0 bits (123), Expect = 3e-06
Identities = 65/257 (25%), Positives = 125/257 (48%), Gaps = 34/257 (13%)
Query: 459 EEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPT 518
EE+ EDE +K +++ +Q +NEL+++++ + K+L + + +A +T
Sbjct: 858 EEEMQAKEDELQKTKER-------QQKAENELKELEQKHSQLTEEKNLLQEQLQA-ETEL 909
Query: 519 EEDNEDLKCQLQFVKEE-AALMRKKMAKIDKEKDR---FEHELQKYRSFYGDLDSPLPKG 574
+ E+++ +L K+E ++ + A++++E+DR + E +K DL+ L +
Sbjct: 910 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 969
Query: 575 EAGGPPSTREAELKLRLRLVEEEANI--LGRKIVELEVENRGLKAE---LDDLRGDDFNG 629
EA A KL+L V EA I L +I+ ++ +N L E L++ D
Sbjct: 970 EA--------ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1021
Query: 630 SANPLMREQSESLSELRQHLQLVEDETELLRRNVADLEEQNKRITAELNKYKYKSGGHDS 689
A E++++L++L+ + + E E+ + EE++++ EL K K K G S
Sbjct: 1022 LAEE--EEKAKNLTKLKNKHESMISELEVRLKK----EEKSRQ---ELEKLKRKLEGDAS 1072
Query: 690 ARHHDNAKTEALQEELK 706
H A +A ELK
Sbjct: 1073 DFHEQIADLQAQIAELK 1089
Score = 42.0 bits (97), Expect = 0.003
Identities = 59/278 (21%), Positives = 111/278 (39%), Gaps = 40/278 (14%)
Query: 255 LQSELIQFHLKKERAAAAAAAAQMHAKNGGGSSSRSSPVSGPPAVCETLAVASASPMAAA 314
LQ+++ F ++E A A+ ++ A S + + E LA A + A
Sbjct: 1657 LQAQMKDF--QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1714
Query: 315 AEGPQQSAEGSASGGGMQAAAPPSSQPHPQQLQEQEEMQEE----------MEKLREENE 364
E + + E ++S G A + + Q +EE++EE + K ++ E
Sbjct: 1715 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1774
Query: 365 TLKNEIDELRT--EMDEMRDTFFEEDACQLQEMRHELERANKN----------CRILQYR 412
L NE+ R+ + +E E +L+ HE+E A K+ +I Q
Sbjct: 1775 QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE 1834
Query: 413 LRKAERKRLRYAQTGEIDG------ELLRSLEQDLKVAKDVSVR----------LHHELE 456
+ + R + A T + E+L +E + K+A+ + L +LE
Sbjct: 1835 EQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLE 1894
Query: 457 NVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMK 494
EE+ KL+++L E + +A+ E+ +K
Sbjct: 1895 EAEEESQRINANRRKLQRELDEATESNEAMGREVNALK 1932
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 83.6 bits (205), Expect = 8e-16
Identities = 97/432 (22%), Positives = 193/432 (44%), Gaps = 48/432 (11%)
Query: 344 QQLQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERAN 403
+QLQ + E+ E E++R K E++E+ EM+ EE+ + Q+++ E ++
Sbjct: 894 EQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEAR----LEEEEDRGQQLQAERKKMA 949
Query: 404 KNCRILQYRLRKAERKRLRYAQTGEIDGEL-LRSLEQDLKVAKDVSVRLHHELENVEEK- 461
+ L+ +L + E R + Q ++ E ++ LE ++ V D + +L E + +EE+
Sbjct: 950 QQMLDLEEQLEEEEAARQKL-QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERI 1008
Query: 462 --RTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTE 519
TT E E+ + L +++ +++ +ELE + K R + K + + +
Sbjct: 1009 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1068
Query: 520 EDNEDLKCQLQFVKEEAALMRKKM----AKIDKEKDRFEHELQKYRSFYG-------DLD 568
E DL+ Q+ +K + A +++ A++D E + + L+K R G DLD
Sbjct: 1069 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1128
Query: 569 SPLP--------KGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEV-------ENR 613
S K + G + EL+ L + + ++ E+ V E R
Sbjct: 1129 SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1188
Query: 614 GLKAELDDLRGDDFNGSANPLMREQSESLSELRQHL----QLVEDET-------ELLRRN 662
+A++ ++R + A + EQ E + +L Q +E E +L +
Sbjct: 1189 SHEAQVQEMRQK--HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQA 1246
Query: 663 VADLEEQNKRITAELNKYKYKSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVMQL 722
++E + K++ A++ + + K + AR N K LQ E+++ +NE GK ++L
Sbjct: 1247 KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKL 1306
Query: 723 QYENRVLMSNMQ 734
+ L S +Q
Sbjct: 1307 AKDVASLSSQLQ 1318
Score = 66.2 bits (160), Expect = 1e-10
Identities = 109/471 (23%), Positives = 190/471 (40%), Gaps = 85/471 (18%)
Query: 331 MQAAAPPSSQPHPQQLQEQEEMQEE-MEKLREENETLKNEIDELRTEMDEMRDTFFEEDA 389
++ A ++ H Q+QE + + +E+L E+ E K + +D+ + T +E+A
Sbjct: 1179 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA----KANLDKNKQTLEKENA 1234
Query: 390 CQL----------QEMRHELERANKNCRILQYRLRKAERKRLRYA--------QTGEIDG 431
QE+ H+ ++ + LQ + ER R + + G
Sbjct: 1235 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1294
Query: 432 ELLRSLEQDLKVAKDVSVRLHHELE--------------NVEEKRTTTEDENEKLRQQLI 477
L + + +K+AKDV+ L +L+ NV K E+E L+ QL
Sbjct: 1295 MLNEAEGKAIKLAKDVA-SLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLD 1353
Query: 478 EVEIAKQALQNEL-----------EKMKELSL--------KRRGSKDLPK-----SEKKA 513
E AKQ L+ + +K+++ + K+R K++ EK A
Sbjct: 1354 EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAA 1413
Query: 514 QQTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPK 573
E+ L+ +L + + R+ ++ ++K++ +F+ L + ++ +
Sbjct: 1414 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1473
Query: 574 GEAGGPPSTREAELK-LRLRLVEEEANILGRKIVELEVENRGLKAELDDL--RGDDFNGS 630
EA RE E K L L EEA L K ELE N+ LKAE++DL DD +
Sbjct: 1474 AEA----EAREKETKALSLARALEEA--LEAK-EELERTNKMLKAEMEDLVSSKDDVGKN 1526
Query: 631 ANPL----------MREQSESLSELRQHLQLVEDETELLRRNVADLE---EQNKRITAEL 677
+ L M E L EL LQ ED L N+ L+ E++ + E
Sbjct: 1527 VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ 1586
Query: 678 NKYKYKSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVMQLQYENRV 728
N+ K + + + E Q L AA + E K ++LQ ++ +
Sbjct: 1587 NEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1637
Score = 58.5 bits (140), Expect = 3e-08
Identities = 91/421 (21%), Positives = 165/421 (39%), Gaps = 51/421 (12%)
Query: 347 QEQEEMQEEMEKLREENETLKNEIDELRTEMDEMR-------------DTFFEEDACQLQ 393
Q+ EE +KL + L+ E+D+L ++D R D E+
Sbjct: 1406 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1465
Query: 394 EMRHELERANKNCRILQYR---LRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVR 450
+ E +RA R + + L +A + L + E ++L++ +DL +KD +
Sbjct: 1466 KYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGK 1525
Query: 451 LHHELENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSE 510
HELE + + E + E+++ QL E+E +EL+ ++ L+ + K +
Sbjct: 1526 NVHELE---KSKRALETQMEEMKTQLEELE-------DELQATEDAKLRLEVNMQALKGQ 1575
Query: 511 KKAQQTPTEEDNEDLKCQLQ----FVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGD 566
+ +E NE+ + QLQ + E RK+ A K + E +L+
Sbjct: 1576 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL---Q 1632
Query: 567 LDSPLPKGEAGGPPSTREAELKLR-LRLVEEEANILGRKIVELEVEN----RGLKAELDD 621
DS + KG R+ + +++ + E+A +I EN + L+A+L
Sbjct: 1633 ADSAI-KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1691
Query: 622 LRGD-----DFNGSANPLMREQSESLSELRQHLQLVEDETELLRRNVADLEEQNKRITAE 676
L+ D A+ E +E L+ ++DE L +A LEE E
Sbjct: 1692 LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEE-------E 1744
Query: 677 LNKYKYKSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVMQLQYENRVLMSNMQRY 736
L + + + E L EL R + QL+ +N+ L S +
Sbjct: 1745 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM 1804
Query: 737 D 737
+
Sbjct: 1805 E 1805
Score = 58.5 bits (140), Expect = 3e-08
Identities = 77/373 (20%), Positives = 153/373 (41%), Gaps = 50/373 (13%)
Query: 347 QEQEEMQEEMEKLREENETLKNEIDELRTEMDE------------------MRDTFFEED 388
Q + ++Q E+ E+ L+ ++ E TE+++ ++D + D
Sbjct: 1575 QFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1634
Query: 389 AC--QLQEMRHELERANKNCRILQYRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKD 446
+ +E +L + + Q L A R T + + + +SLE DL
Sbjct: 1635 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL----- 1689
Query: 447 VSVRLHHELENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMK--------ELSL 498
++L +L E R + E E+L ++L + ALQ+E +++ EL
Sbjct: 1690 --MQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE 1747
Query: 499 KRRGSKDLPKSEKKAQQTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQ 558
++ + + +KA Q + NE + K E+A R+++ + +KE HE++
Sbjct: 1748 EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA--RQQLERQNKELRSKLHEME 1805
Query: 559 -----KYRSFYGDLDSPLPKGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENR 613
K++S L++ + + E RE + + L +++ + K + L+VE+
Sbjct: 1806 GAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK-SLKQKDKKL---KEILLQVEDE 1861
Query: 614 GLKAELDDLRGDDFNGSANPLMREQSESLSELRQHLQLVEDETELLRRNVADLEEQNKRI 673
AE + + N L R+ L E + Q + L+R + + E N+ +
Sbjct: 1862 RKMAEQYKEQAEKGNARVKQLKRQ----LEEAEEESQRINANRRKLQRELDEATESNEAM 1917
Query: 674 TAELNKYKYKSGG 686
E+N K K G
Sbjct: 1918 GREVNALKSKLRG 1930
Score = 57.0 bits (136), Expect = 8e-08
Identities = 121/584 (20%), Positives = 231/584 (39%), Gaps = 87/584 (14%)
Query: 391 QLQEMRHELERANKNCRILQYRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVR 450
++Q EL++ + + + L++ E+K + + + E L++ + A+++ VR
Sbjct: 853 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 912
Query: 451 LH----------HE----LENVEEKRTTTEDENEKLRQQLI-------EVEIAKQALQ-- 487
L HE LE E++ + E +K+ QQ++ E E A+Q LQ
Sbjct: 913 LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE 972
Query: 488 ----------------------NELEKMKELSLKRRG--SKDLPKSEKKAQQ-TPTEEDN 522
N+L K ++L +R + +L + E+KA+ T + +
Sbjct: 973 KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1032
Query: 523 EDLKCQLQF-VKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGEAGGPPS 581
E + +L+ +K+E K +++K K + E + + DL + + E +
Sbjct: 1033 ESMISELEVRLKKE----EKSRQELEKLKRKLEGDASDFHEQIADLQAQI--AELKMQLA 1086
Query: 582 TREAELKLRLRLVEEE---ANILGRKIVELEVENRGLKAELDDLRGDDFNGSANPLMREQ 638
+E EL+ L +++E N +KI ELE L+ +LD R A R+
Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA--ARNKAEKQKRDL 1144
Query: 639 SESLSELRQHLQLVEDETELLRRNVADLEEQNKRITAELNKYKYKSGGHDSARHHDNAKT 698
E L L+ L+ D T +Q R E K + R H+
Sbjct: 1145 GEELEALKTELEDTLDST---------ATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1195
Query: 699 EALQEELKAARLQINELSGKVMQLQYENRVLMSNMQ-----RYDLASHLGIRGSPRDSDA 753
E Q+ +A + EL+ ++ Q + L N Q DLA L + G +
Sbjct: 1196 EMRQKHAQA----VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ--- 1248
Query: 754 ESDAGKKESDDDSRPPHRK-REGPIGGESDSEEVRNIR--CLTPTRSFYPAPGPWPKSFS 810
E + KK+ + + K +G +++V ++ + T A G K
Sbjct: 1249 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1308
Query: 811 DRQQMKDIRSEAERLGKTIDRLIADTSTIITEARIYVANGDLFGLMDEEDDGSRIREHEL 870
D + + + L + R + ST + + + L +DEE + + E
Sbjct: 1309 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQ--LEEERNSLQDQLDEEMEAKQNLERH- 1365
Query: 871 LYRINAQMKAFRKELQTFIDRLEVPKSADDRGAEEPISVSQMFQ 914
+ +N Q+ +K+LQ F +E + R +E +++Q ++
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1409
Score = 52.0 bits (123), Expect = 3e-06
Identities = 65/257 (25%), Positives = 125/257 (48%), Gaps = 34/257 (13%)
Query: 459 EEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPT 518
EE+ EDE +K +++ +Q +NEL+++++ + K+L + + +A +T
Sbjct: 851 EEEMQAKEDELQKTKER-------QQKAENELKELEQKHSQLTEEKNLLQEQLQA-ETEL 902
Query: 519 EEDNEDLKCQLQFVKEE-AALMRKKMAKIDKEKDR---FEHELQKYRSFYGDLDSPLPKG 574
+ E+++ +L K+E ++ + A++++E+DR + E +K DL+ L +
Sbjct: 903 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 962
Query: 575 EAGGPPSTREAELKLRLRLVEEEANI--LGRKIVELEVENRGLKAE---LDDLRGDDFNG 629
EA A KL+L V EA I L +I+ ++ +N L E L++ D
Sbjct: 963 EA--------ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1014
Query: 630 SANPLMREQSESLSELRQHLQLVEDETELLRRNVADLEEQNKRITAELNKYKYKSGGHDS 689
A E++++L++L+ + + E E+ + EE++++ EL K K K G S
Sbjct: 1015 LAEE--EEKAKNLTKLKNKHESMISELEVRLKK----EEKSRQ---ELEKLKRKLEGDAS 1065
Query: 690 ARHHDNAKTEALQEELK 706
H A +A ELK
Sbjct: 1066 DFHEQIADLQAQIAELK 1082
Score = 42.0 bits (97), Expect = 0.003
Identities = 59/278 (21%), Positives = 111/278 (39%), Gaps = 40/278 (14%)
Query: 255 LQSELIQFHLKKERAAAAAAAAQMHAKNGGGSSSRSSPVSGPPAVCETLAVASASPMAAA 314
LQ+++ F ++E A A+ ++ A S + + E LA A + A
Sbjct: 1650 LQAQMKDF--QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1707
Query: 315 AEGPQQSAEGSASGGGMQAAAPPSSQPHPQQLQEQEEMQEE----------MEKLREENE 364
E + + E ++S G A + + Q +EE++EE + K ++ E
Sbjct: 1708 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1767
Query: 365 TLKNEIDELRT--EMDEMRDTFFEEDACQLQEMRHELERANKN----------CRILQYR 412
L NE+ R+ + +E E +L+ HE+E A K+ +I Q
Sbjct: 1768 QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE 1827
Query: 413 LRKAERKRLRYAQTGEIDG------ELLRSLEQDLKVAKDVSVR----------LHHELE 456
+ + R + A T + E+L +E + K+A+ + L +LE
Sbjct: 1828 EQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLE 1887
Query: 457 NVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMK 494
EE+ KL+++L E + +A+ E+ +K
Sbjct: 1888 EAEEESQRINANRRKLQRELDEATESNEAMGREVNALK 1925
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 83.2 bits (204), Expect = 1e-15
Identities = 114/476 (23%), Positives = 198/476 (41%), Gaps = 117/476 (24%)
Query: 335 APPSSQPHPQQLQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQE 394
AP S H + E + KL EN++L ++ELRT +D + E +A ++ +
Sbjct: 445 APQKSLGH----EVNELTSSRLLKLEMENQSLTKTVEELRTTVDSV-----EGNASKILK 495
Query: 395 MRHELERANKNCRILQYRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHE 454
M E +R +K IL+ + + E++ L+ Q + +L++ Q K + +
Sbjct: 496 MEKENQRLSKKVEILENEIVQ-EKQSLQNCQN--LSKDLMKEKAQLEKTIETLR------ 546
Query: 455 LENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQ 514
EN E + E ENE L Q + + L + ++S + R KD+ K K
Sbjct: 547 -ENSERQIKILEQENEHLNQTV-----------SSLRQRSQISAEAR-VKDIEKENKILH 593
Query: 515 QTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKG 574
++ +KE ++ K++KI+ EK + + EL+ Y+ KG
Sbjct: 594 ES---------------IKETSS----KLSKIEFEKRQIKKELEHYKE----------KG 624
Query: 575 EAGGPPSTREAELKLRLRLVEEEANILGRKIV-----------------ELEVENRGLKA 617
E R EL+ L +E+E +L +KI ELE ENR LK
Sbjct: 625 E-------RAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKK 677
Query: 618 ELDDLRGDDFNGSANPLMREQSESLSELRQHLQLVEDETELLRRNV----------ADLE 667
LD + F Q ESL +++ QL E+ EL RRNV A L+
Sbjct: 678 TLDSFKNLTF----------QLESLE--KENSQLDEENLEL-RRNVESLKCASMKMAQLQ 724
Query: 668 EQNKRITAELNKYKY----------KSGGHDSARHHDNAKTEALQEELKAARLQINELSG 717
+NK + +E + K K+ + + + + + LQ+ L+ + +I +L
Sbjct: 725 LENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLES 784
Query: 718 KVMQLQYENRVLMSNMQRYDLASHLGIRGSPRDSDAESDAGKKESDDDSRPPHRKR 773
++ L+ EN+ L N++ ++S + + E + + E D KR
Sbjct: 785 ELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR 840
Score = 76.6 bits (187), Expect = 1e-13
Identities = 93/390 (23%), Positives = 173/390 (44%), Gaps = 50/390 (12%)
Query: 350 EEMQEEMEKLREENETLKNEIDEL-----RTEMDEMRDTFFEEDACQLQEMRHELERANK 404
++++ E++ L EN+TL+ ++EL R E E + E++ QL++ + +LE+ NK
Sbjct: 780 QQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENK 839
Query: 405 NCRILQYRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHH-ELENVEEKRT 463
R+ Q K + G ++ E ++L +++ + K+ VRL E EN E +
Sbjct: 840 --RLRQQAEIKDTTLEENNVKIGNLEKE-NKTLSKEIGIYKESCVRLKELEKENKELVKR 896
Query: 464 TTEDENE--KLRQQLIEVEIAKQALQNELEK----MKELSL-KRRGSKDLPKSEKKAQQT 516
T D LR+ L+ ++ Q + N+LEK ++++ L K R D ++ +
Sbjct: 897 ATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKL 956
Query: 517 PTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDL--------- 567
+ LK L+ +E+ A + ++ + + EL+ + Y L
Sbjct: 957 LESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERM 1016
Query: 568 --DSPLPKGEAG-----GPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELD 620
SP GE +TRE LK++ RL+E E R L+ E + LK +L
Sbjct: 1017 VQSSPPISGEDNKWERESQETTREL-LKVKDRLIEVE-----RNNATLQAEKQALKTQLK 1070
Query: 621 DLRGDDFNGSANPLMREQSESLSELRQHLQLVEDETELLRRNVADLEEQNKRITAELNKY 680
L + N Q++ L+ RQ + L E T L +N A L+ +N + ++
Sbjct: 1071 QLETQNNN--------LQAQILALQRQTVSLQEQNTTLQTQN-AKLQVENSTLNSQSTSL 1121
Query: 681 KYKSGG---HDSARHHDNAKTEALQEELKA 707
++ S+ ++N +E+LK+
Sbjct: 1122 MNQNAQLLIQQSSLENENESVIKEREDLKS 1151
Score = 70.1 bits (170), Expect = 9e-12
Identities = 102/451 (22%), Positives = 198/451 (43%), Gaps = 66/451 (14%)
Query: 347 QEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERANKNC 406
+ EE++ E+ L +ENE L+ +I L+ +++ E++ +L+ +L++ +
Sbjct: 625 ERAEELENELHHLEKENELLQKKITNLKITCEKIE--ALEQENSELERENRKLKKTLDSF 682
Query: 407 RILQYRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTTE 466
+ L ++L E++ +Q E + EL R++E LK A +L +LEN E E
Sbjct: 683 KNLTFQLESLEKEN---SQLDEENLELRRNVE-SLKCASMKMAQL--QLENKE-----LE 731
Query: 467 DENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRG--------SKDLPKSEKKAQQTPT 518
E E+L++ L + L+ +K + L + +G K L S KK QQ +
Sbjct: 732 SEKEQLKKGL-------ELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLES 784
Query: 519 EEDNEDLKCQ-LQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGEAG 577
E + +++ Q LQ EE + K++ +++KE E E + L+ + E
Sbjct: 785 ELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQ-------LEKDKKQLEKE 837
Query: 578 GPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAEL-----DDLRGDDFNGSAN 632
++AE+K EE N+ KI LE EN+ L E+ +R +
Sbjct: 838 NKRLRQQAEIK---DTTLEENNV---KIGNLEKENKTLSKEIGIYKESCVRLKELEKENK 891
Query: 633 PLMREQS---ESLSELRQHLQLVEDETELLRRNVADLEEQNKRITAELNKYKYKSGGHDS 689
L++ + ++L LR+ L + +T+ + ++ L + ++I + + D
Sbjct: 892 ELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDD 951
Query: 690 ARHH---------DNAKTEALQEELKAARLQINELSGKVMQLQYENRVLMSN----MQRY 736
+R+ E +E++ A ++ E + QL+ E + + N QR
Sbjct: 952 SRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQ 1011
Query: 737 DLASHLGIRGSPRDSDAESDAGKKESDDDSR 767
D ++ SP S E + ++ES + +R
Sbjct: 1012 D--EERMVQSSPPIS-GEDNKWERESQETTR 1039
Score = 65.5 bits (158), Expect = 2e-10
Identities = 81/396 (20%), Positives = 172/396 (43%), Gaps = 60/396 (15%)
Query: 347 QEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERANKNC 406
QE E+M+ E+++L++EN L ++ R DE+ E A ++ ++ E+ R +
Sbjct: 279 QELEQMEIELKRLQQENMNLLSDARSARMYRDEL--DALREKAVRVDKLESEVSRYKERL 336
Query: 407 RILQYRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENV---EEKRT 463
+++ + E L++D +V + L +LE +K
Sbjct: 337 HDIEFYKARVE------------------ELKEDNQVLLETKTMLEDQLEGTRARSDKLH 378
Query: 464 TTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTEEDNE 523
E EN +L+ +L ++E+ + + ++E++ E ++ L ++K++ +++
Sbjct: 379 ELEKENLQLKAKLHDMEMERDMDRKKIEELMEENM------TLEMAQKQSM-----DESL 427
Query: 524 DLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGEAGGPPSTR 583
L +L+ + + L + HE+ + S S L K E T+
Sbjct: 428 HLGWELEQISRTSELSEAPQKSLG-------HEVNELTS------SRLLKLEMENQSLTK 474
Query: 584 EAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDLRGDDFNGSANPLMREQSESLS 643
E +LR + E N KI+++E EN+ L +++ L ++ L Q+ S
Sbjct: 475 TVE-ELRTTVDSVEGN--ASKILKMEKENQRLSKKVEILE-NEIVQEKQSLQNCQNLSKD 530
Query: 644 ELRQHLQL---VEDETELLRRNVADLEEQNKRITAELNKYKYKSGGHDSARHHDNAKTEA 700
+++ QL +E E R + LE++N+ + ++ + +S AR D
Sbjct: 531 LMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKD------ 584
Query: 701 LQEELKAARLQINELSGKVMQLQYENRVLMSNMQRY 736
+++E K I E S K+ ++++E R + ++ Y
Sbjct: 585 IEKENKILHESIKETSSKLSKIEFEKRQIKKELEHY 620
Score = 45.4 bits (106), Expect = 2e-04
Identities = 106/516 (20%), Positives = 201/516 (38%), Gaps = 87/516 (16%)
Query: 432 ELLRSLEQDLKVAKDVSVR-LHHELENV------EEKRTTTEDENEKLRQQLIEVEIAKQ 484
E ++ L+ D K A ++ + H ENV E + ED L+ + ++
Sbjct: 143 ERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLID 202
Query: 485 ALQNELEKMKELSLKRRGSKDLPKSEKKAQQ---TPTEEDNE----------DLKCQLQF 531
E + ELS +R G LP + AQ +P + E D K +++
Sbjct: 203 ERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRR 262
Query: 532 VKEEAALMRKKMAKIDKEKDRFEHELQKY--------------RSFYGDLDSPLPKGEAG 577
+++E +++ +E ++ E EL++ R + +LD+ K
Sbjct: 263 LRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRV 322
Query: 578 GPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDLRGDDFNGSANPLMRE 637
+ + K RL +E ++ EL+ +N+ L E + D G+ R
Sbjct: 323 DKLESEVSRYKERLHDIE----FYKARVEELKEDNQVL-LETKTMLEDQLEGT-----RA 372
Query: 638 QSESLSEL-RQHLQL------VEDETELLRRNVADLEEQNKRITAEL-NKYKYKSGGHDS 689
+S+ L EL +++LQL +E E ++ R+ + +L E+N +T E+ K H
Sbjct: 373 RSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEEN--MTLEMAQKQSMDESLHLG 430
Query: 690 ARHHDNAKTEALQE-ELKAARLQINEL-SGKVMQLQYENRVLMSNMQRYDLASHLGIRGS 747
++T L E K+ ++NEL S ++++L+ EN+ L ++
Sbjct: 431 WELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTV------- 483
Query: 748 PRDSDAESDAGKKESDDDSRPPHRKREGPIGGESDSEEVRNIRCLTPTRSFYPAPGPWPK 807
E +A K + K+ + E E+ C ++ K
Sbjct: 484 ---DSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK 540
Query: 808 SF-----SDRQQMKDIRSEAERLGKTIDRLIADTSTIITEARIYVANGDLFGLMDEEDDG 862
+ + +Q+K + E E L +T+ L S I EAR+ D E +
Sbjct: 541 TIETLRENSERQIKILEQENEHLNQTVSSL-RQRSQISAEARV----------KDIEKEN 589
Query: 863 SRIRE-----HELLYRINAQMKAFRKELQTFIDRLE 893
+ E L +I + + +KEL+ + ++ E
Sbjct: 590 KILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGE 625
Score = 42.4 bits (98), Expect = 0.002
Identities = 75/375 (20%), Positives = 150/375 (40%), Gaps = 65/375 (17%)
Query: 331 MQAAAPPSSQPHPQQLQEQEEMQE---------EMEK----LREENETLKNEIDELRTEM 377
+Q++ P S + + + + QE +E E+E+ L+ E + LK ++ +L T+
Sbjct: 1017 VQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQN 1076
Query: 378 DEMRDTFF--EEDACQLQEMRHELERANKNCRILQYRLRKA------ERKRLRYAQTG-E 428
+ ++ + LQE L+ N ++ L + +L Q+ E
Sbjct: 1077 NNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLE 1136
Query: 429 IDGELLRSLEQDLKVAKDVSVRLHHELE-------------------------NVEEKRT 463
+ E + +DLK D ++ H +LE N+E +
Sbjct: 1137 NENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHR 1196
Query: 464 TTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKK--AQQTPTEED 521
ED +L +Q ++E ++ L+ E EKM L+ + + + KK +
Sbjct: 1197 DLEDRYNQLLKQKGQLEDLEKMLKVEQEKM---LLENKNHETVAAEYKKLCGENDRLNHT 1253
Query: 522 NEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGEAGGPPS 581
L + + ++ + ++ + E+ R E E K + Y LD K
Sbjct: 1254 YSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTK-------L 1306
Query: 582 TREAELKLRLR-LVEEEANILGRKIVELEVENRGLKAELDDLRGDDFNGSANPLMREQSE 640
+ EL +L+ +EEE L +I L ++NR L + ++ D + R+ +
Sbjct: 1307 NNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQ--NMESKDL---FHVEQRQYID 1361
Query: 641 SLSELRQHLQLVEDE 655
L+ELR+ + +E++
Sbjct: 1362 KLNELRRQKEKLEEK 1376
Score = 39.3 bits (90), Expect = 0.018
Identities = 56/224 (25%), Positives = 96/224 (42%), Gaps = 27/224 (12%)
Query: 345 QLQEQEEMQE-EMEKLREEN---ETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELE 400
QL++ E+M + E EK+ EN ET+ E +L E D + T+ QL + L+
Sbjct: 1211 QLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTY-----SQLLKETEVLQ 1265
Query: 401 RANKNCRILQYRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEE 460
+KN + L K E+ RL E + L+ Q L + S +L+++ E + +
Sbjct: 1266 TDHKNLKSLLNN-SKLEQTRL------EAEFSKLKEQYQQLDIT---STKLNNQCELLSQ 1315
Query: 461 KRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTEE 520
+ E+EN L Q+ + + + L + + K+L + +E + Q+ EE
Sbjct: 1316 LKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEE 1375
Query: 521 DNEDLKCQLQFV-----KEEAALMRKKMAKIDKEKDRFEHELQK 559
D Q +F + + KM K+ K K E QK
Sbjct: 1376 KIMD---QYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQK 1416
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 83.2 bits (204), Expect = 1e-15
Identities = 114/476 (23%), Positives = 198/476 (41%), Gaps = 117/476 (24%)
Query: 335 APPSSQPHPQQLQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQE 394
AP S H + E + KL EN++L ++ELRT +D + E +A ++ +
Sbjct: 445 APQKSLGH----EVNELTSSRLLKLEMENQSLTKTVEELRTTVDSV-----EGNASKILK 495
Query: 395 MRHELERANKNCRILQYRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHE 454
M E +R +K IL+ + + E++ L+ Q + +L++ Q K + +
Sbjct: 496 MEKENQRLSKKVEILENEIVQ-EKQSLQNCQN--LSKDLMKEKAQLEKTIETLR------ 546
Query: 455 LENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQ 514
EN E + E ENE L Q + + L + ++S + R KD+ K K
Sbjct: 547 -ENSERQIKILEQENEHLNQTV-----------SSLRQRSQISAEAR-VKDIEKENKILH 593
Query: 515 QTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKG 574
++ +KE ++ K++KI+ EK + + EL+ Y+ KG
Sbjct: 594 ES---------------IKETSS----KLSKIEFEKRQIKKELEHYKE----------KG 624
Query: 575 EAGGPPSTREAELKLRLRLVEEEANILGRKIV-----------------ELEVENRGLKA 617
E R EL+ L +E+E +L +KI ELE ENR LK
Sbjct: 625 E-------RAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKK 677
Query: 618 ELDDLRGDDFNGSANPLMREQSESLSELRQHLQLVEDETELLRRNV----------ADLE 667
LD + F Q ESL +++ QL E+ EL RRNV A L+
Sbjct: 678 TLDSFKNLTF----------QLESLE--KENSQLDEENLEL-RRNVESLKCASMKMAQLQ 724
Query: 668 EQNKRITAELNKYKY----------KSGGHDSARHHDNAKTEALQEELKAARLQINELSG 717
+NK + +E + K K+ + + + + + LQ+ L+ + +I +L
Sbjct: 725 LENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLES 784
Query: 718 KVMQLQYENRVLMSNMQRYDLASHLGIRGSPRDSDAESDAGKKESDDDSRPPHRKR 773
++ L+ EN+ L N++ ++S + + E + + E D KR
Sbjct: 785 ELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR 840
Score = 75.5 bits (184), Expect = 2e-13
Identities = 91/389 (23%), Positives = 171/389 (43%), Gaps = 49/389 (12%)
Query: 350 EEMQEEMEKLREENETLKNEIDEL-----RTEMDEMRDTFFEEDACQLQEMRHELERANK 404
++++ E++ L EN+TL+ ++EL R E E + E++ QL++ + +LE+ NK
Sbjct: 780 QQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENK 839
Query: 405 NCRILQYRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHH-ELENVEEKRT 463
R+ Q K + G ++ E ++L +++ + K+ VRL E EN E +
Sbjct: 840 --RLRQQAEIKDTTLEENNVKIGNLEKE-NKTLSKEIGIYKESCVRLKELEKENKELVKR 896
Query: 464 TTEDENE--KLRQQLIEVEIAKQALQNELEK----MKELSLKRRGSKDLPKSEKKAQQTP 517
T D LR+ L+ ++ Q + N+LEK ++++ L + +S +
Sbjct: 897 ATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLL 956
Query: 518 TEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDL---------- 567
+ LK L+ +E+ A + ++ + + EL+ + Y L
Sbjct: 957 ESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMV 1016
Query: 568 -DSPLPKGEAG-----GPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDD 621
SP GE +TRE LK++ RL+E E R L+ E + LK +L
Sbjct: 1017 QSSPPISGEDNKWERESQETTREL-LKVKDRLIEVE-----RNNATLQAEKQALKTQLKQ 1070
Query: 622 LRGDDFNGSANPLMREQSESLSELRQHLQLVEDETELLRRNVADLEEQNKRITAELNKYK 681
L + N Q++ L+ RQ + L E T L +N A L+ +N + ++
Sbjct: 1071 LETQNNN--------LQAQILALQRQTVSLQEQNTTLQTQN-AKLQVENSTLNSQSTSLM 1121
Query: 682 YKSGG---HDSARHHDNAKTEALQEELKA 707
++ S+ ++N +E+LK+
Sbjct: 1122 NQNAQLLIQQSSLENENESVIKEREDLKS 1150
Score = 69.3 bits (168), Expect = 2e-11
Identities = 107/455 (23%), Positives = 200/455 (43%), Gaps = 75/455 (16%)
Query: 347 QEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERANKNC 406
+ EE++ E+ L +ENE L+ +I L+ +++ E++ +L+ +L++ +
Sbjct: 625 ERAEELENELHHLEKENELLQKKITNLKITCEKIE--ALEQENSELERENRKLKKTLDSF 682
Query: 407 RILQYRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTTE 466
+ L ++L E++ +Q E + EL R++E LK A +L +LEN E E
Sbjct: 683 KNLTFQLESLEKEN---SQLDEENLELRRNVE-SLKCASMKMAQL--QLENKE-----LE 731
Query: 467 DENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRG--------SKDLPKSEKKAQQTPT 518
E E+L++ L + L+ +K + L + +G K L S KK QQ +
Sbjct: 732 SEKEQLKKGL-------ELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLES 784
Query: 519 EEDNEDLKCQ-LQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGEAG 577
E + +++ Q LQ EE + K++ +++KE E E + L+ + E
Sbjct: 785 ELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQ-------LEKDKKQLEKE 837
Query: 578 GPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAEL-----DDLRGDDFNGSAN 632
++AE+K EE N+ KI LE EN+ L E+ +R +
Sbjct: 838 NKRLRQQAEIK---DTTLEENNV---KIGNLEKENKTLSKEIGIYKESCVRLKELEKENK 891
Query: 633 PLMREQS---ESLSELRQHLQLVEDETELLRRNVADLEEQNKRITAELNKYKYKSGGHDS 689
L++ + ++L LR+ L + +T+ + ++ L + ++I LNK + HD
Sbjct: 892 ELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKI--GLNKERLL---HDE 946
Query: 690 ARHHDNAK-------------TEALQEELKAARLQINELSGKVMQLQYENRVLMSN---- 732
D K E +E++ A ++ E + QL+ E + + N
Sbjct: 947 QSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEAL 1006
Query: 733 MQRYDLASHLGIRGSPRDSDAESDAGKKESDDDSR 767
QR D ++ SP S E + ++ES + +R
Sbjct: 1007 KQRQD--EERMVQSSPPIS-GEDNKWERESQETTR 1038
Score = 65.5 bits (158), Expect = 2e-10
Identities = 81/396 (20%), Positives = 172/396 (43%), Gaps = 60/396 (15%)
Query: 347 QEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERANKNC 406
QE E+M+ E+++L++EN L ++ R DE+ E A ++ ++ E+ R +
Sbjct: 279 QELEQMEIELKRLQQENMNLLSDARSARMYRDEL--DALREKAVRVDKLESEVSRYKERL 336
Query: 407 RILQYRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENV---EEKRT 463
+++ + E L++D +V + L +LE +K
Sbjct: 337 HDIEFYKARVE------------------ELKEDNQVLLETKTMLEDQLEGTRARSDKLH 378
Query: 464 TTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTEEDNE 523
E EN +L+ +L ++E+ + + ++E++ E ++ L ++K++ +++
Sbjct: 379 ELEKENLQLKAKLHDMEMERDMDRKKIEELMEENM------TLEMAQKQSM-----DESL 427
Query: 524 DLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGEAGGPPSTR 583
L +L+ + + L + HE+ + S S L K E T+
Sbjct: 428 HLGWELEQISRTSELSEAPQKSLG-------HEVNELTS------SRLLKLEMENQSLTK 474
Query: 584 EAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDLRGDDFNGSANPLMREQSESLS 643
E +LR + E N KI+++E EN+ L +++ L ++ L Q+ S
Sbjct: 475 TVE-ELRTTVDSVEGN--ASKILKMEKENQRLSKKVEILE-NEIVQEKQSLQNCQNLSKD 530
Query: 644 ELRQHLQL---VEDETELLRRNVADLEEQNKRITAELNKYKYKSGGHDSARHHDNAKTEA 700
+++ QL +E E R + LE++N+ + ++ + +S AR D
Sbjct: 531 LMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKD------ 584
Query: 701 LQEELKAARLQINELSGKVMQLQYENRVLMSNMQRY 736
+++E K I E S K+ ++++E R + ++ Y
Sbjct: 585 IEKENKILHESIKETSSKLSKIEFEKRQIKKELEHY 620
Score = 45.4 bits (106), Expect = 2e-04
Identities = 106/516 (20%), Positives = 201/516 (38%), Gaps = 87/516 (16%)
Query: 432 ELLRSLEQDLKVAKDVSVR-LHHELENV------EEKRTTTEDENEKLRQQLIEVEIAKQ 484
E ++ L+ D K A ++ + H ENV E + ED L+ + ++
Sbjct: 143 ERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLID 202
Query: 485 ALQNELEKMKELSLKRRGSKDLPKSEKKAQQ---TPTEEDNE----------DLKCQLQF 531
E + ELS +R G LP + AQ +P + E D K +++
Sbjct: 203 ERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRR 262
Query: 532 VKEEAALMRKKMAKIDKEKDRFEHELQKY--------------RSFYGDLDSPLPKGEAG 577
+++E +++ +E ++ E EL++ R + +LD+ K
Sbjct: 263 LRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRV 322
Query: 578 GPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDLRGDDFNGSANPLMRE 637
+ + K RL +E ++ EL+ +N+ L E + D G+ R
Sbjct: 323 DKLESEVSRYKERLHDIE----FYKARVEELKEDNQVL-LETKTMLEDQLEGT-----RA 372
Query: 638 QSESLSEL-RQHLQL------VEDETELLRRNVADLEEQNKRITAEL-NKYKYKSGGHDS 689
+S+ L EL +++LQL +E E ++ R+ + +L E+N +T E+ K H
Sbjct: 373 RSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEEN--MTLEMAQKQSMDESLHLG 430
Query: 690 ARHHDNAKTEALQE-ELKAARLQINEL-SGKVMQLQYENRVLMSNMQRYDLASHLGIRGS 747
++T L E K+ ++NEL S ++++L+ EN+ L ++
Sbjct: 431 WELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTV------- 483
Query: 748 PRDSDAESDAGKKESDDDSRPPHRKREGPIGGESDSEEVRNIRCLTPTRSFYPAPGPWPK 807
E +A K + K+ + E E+ C ++ K
Sbjct: 484 ---DSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK 540
Query: 808 SF-----SDRQQMKDIRSEAERLGKTIDRLIADTSTIITEARIYVANGDLFGLMDEEDDG 862
+ + +Q+K + E E L +T+ L S I EAR+ D E +
Sbjct: 541 TIETLRENSERQIKILEQENEHLNQTVSSL-RQRSQISAEARV----------KDIEKEN 589
Query: 863 SRIRE-----HELLYRINAQMKAFRKELQTFIDRLE 893
+ E L +I + + +KEL+ + ++ E
Sbjct: 590 KILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGE 625
Score = 42.4 bits (98), Expect = 0.002
Identities = 75/375 (20%), Positives = 150/375 (40%), Gaps = 65/375 (17%)
Query: 331 MQAAAPPSSQPHPQQLQEQEEMQE---------EMEK----LREENETLKNEIDELRTEM 377
+Q++ P S + + + + QE +E E+E+ L+ E + LK ++ +L T+
Sbjct: 1016 VQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQN 1075
Query: 378 DEMRDTFF--EEDACQLQEMRHELERANKNCRILQYRLRKA------ERKRLRYAQTG-E 428
+ ++ + LQE L+ N ++ L + +L Q+ E
Sbjct: 1076 NNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLE 1135
Query: 429 IDGELLRSLEQDLKVAKDVSVRLHHELE-------------------------NVEEKRT 463
+ E + +DLK D ++ H +LE N+E +
Sbjct: 1136 NENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHR 1195
Query: 464 TTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKK--AQQTPTEED 521
ED +L +Q ++E ++ L+ E EKM L+ + + + KK +
Sbjct: 1196 DLEDRYNQLLKQKGQLEDLEKMLKVEQEKM---LLENKNHETVAAEYKKLCGENDRLNHT 1252
Query: 522 NEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGEAGGPPS 581
L + + ++ + ++ + E+ R E E K + Y LD K
Sbjct: 1253 YSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTK-------L 1305
Query: 582 TREAELKLRLR-LVEEEANILGRKIVELEVENRGLKAELDDLRGDDFNGSANPLMREQSE 640
+ EL +L+ +EEE L +I L ++NR L + ++ D + R+ +
Sbjct: 1306 NNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQ--NMESKDL---FHVEQRQYID 1360
Query: 641 SLSELRQHLQLVEDE 655
L+ELR+ + +E++
Sbjct: 1361 KLNELRRQKEKLEEK 1375
Score = 39.3 bits (90), Expect = 0.018
Identities = 56/224 (25%), Positives = 96/224 (42%), Gaps = 27/224 (12%)
Query: 345 QLQEQEEMQE-EMEKLREEN---ETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELE 400
QL++ E+M + E EK+ EN ET+ E +L E D + T+ QL + L+
Sbjct: 1210 QLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTY-----SQLLKETEVLQ 1264
Query: 401 RANKNCRILQYRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEE 460
+KN + L K E+ RL E + L+ Q L + S +L+++ E + +
Sbjct: 1265 TDHKNLKSLLNN-SKLEQTRL------EAEFSKLKEQYQQLDIT---STKLNNQCELLSQ 1314
Query: 461 KRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTEE 520
+ E+EN L Q+ + + + L + + K+L + +E + Q+ EE
Sbjct: 1315 LKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEE 1374
Query: 521 DNEDLKCQLQFV-----KEEAALMRKKMAKIDKEKDRFEHELQK 559
D Q +F + + KM K+ K K E QK
Sbjct: 1375 KIMD---QYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQK 1415
>gi|148612801 KIAA1009 protein [Homo sapiens]
Length = 1403
Score = 76.3 bits (186), Expect = 1e-13
Identities = 94/438 (21%), Positives = 194/438 (44%), Gaps = 46/438 (10%)
Query: 332 QAAAPPSSQPHPQQLQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQ 391
+AA P + + Q +E +E + ++ ++ENE L N++ +L+ + + + F+E+
Sbjct: 693 EAADPVTGEKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKENQSL 752
Query: 392 LQEMRHELERANKNCRILQYRLRKAERKR----------LRYAQTGEIDGELLRSLEQDL 441
E+ E+ +K+ R L + +E R LR AQ + SL +D+
Sbjct: 753 FSEVASLKEQMHKS-RFLSQVVEDSEPTRNQNFTDLLAELRMAQKEK------DSLLEDI 805
Query: 442 KVAKDVSVRLHHELENVEEKRTTTEDENEKLR-QQLIEVEIAKQALQNELEKM-KELSLK 499
K K L + E ++++R +D+ + ++L E++I ++ + E+ ++ K L
Sbjct: 806 KRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEKLYEIKILEETHKQEISRLQKRLQWY 865
Query: 500 RRGSKDLPKSEKKAQQTPTEEDNEDLKCQLQFVKEEAA--LMRKKMAKIDKEKDR----- 552
+ L K + ++ E+ E LK +++ +K E+ +R+K+ DK D
Sbjct: 866 AENQELLDKDALRLREA--NEEIEKLKLEIEKLKAESGNPSIRQKIRLKDKAADAKKIQD 923
Query: 553 FEHELQKY-----RSFYGDLDSPLPKGEAGGPPSTREAELKLRLRLVEEEANILGR---- 603
E ++++ R + L + + A G + + R+ + EA++ G+
Sbjct: 924 LERQVKEMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDA 983
Query: 604 --KIVELEVENRGLKAELDDLRGDDFNGSANPLMREQSESLSELRQHLQLVEDETELLRR 661
+ +E + + +K + + A L + S + L + L +++ ++ R
Sbjct: 984 KKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPRIKALEKELDDIKEAHQITVR 1043
Query: 662 NVADLEEQNKRITAELNKYKYKSGGHDSA-------RHHDNAKTEALQEELKAARLQINE 714
N+ + K AEL+ K D + H AK L EEL A + +I +
Sbjct: 1044 NLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQD 1103
Query: 715 LSGKVMQLQYENRVLMSN 732
LS V +LQ + R+++SN
Sbjct: 1104 LSKTVERLQKDRRMMLSN 1121
Score = 33.5 bits (75), Expect = 0.96
Identities = 47/239 (19%), Positives = 106/239 (44%), Gaps = 28/239 (11%)
Query: 340 QPHPQQLQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHEL 399
QPH E+ +E +L+ E E L +E +EL+ + + + + F + +
Sbjct: 1160 QPHTFTDSHVSEVLQENYRLKNELEGLISEKNELKMKSEAVMNQF-----------ENSM 1208
Query: 400 ERANKNCRILQYRLRKAERKRL-RYAQTGEIDGELLRSLEQDLKVAKDVSVRLH-----H 453
R ++ L+ + ++ + + ++ + E + K+A + H +
Sbjct: 1209 RRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELNRKIATQEVLIRHFQSQVN 1268
Query: 454 ELENVEEKRTTTEDENEKLRQQLIE-VEIAKQALQNELEKMKELSLKRRGSKDLPKSEKK 512
EL++ +E +E E L++++ + +E ++A +N +MK + K + +
Sbjct: 1269 ELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEMKHFVGLEKKIKQMEMRHAQ 1328
Query: 513 AQQTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPL 571
+Q E + ++ Q V+ E +K ++ + K+R EL+K+R+ +LDS L
Sbjct: 1329 REQ----ELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNR---ELEKFRT---ELDSIL 1377
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 75.5 bits (184), Expect = 2e-13
Identities = 87/397 (21%), Positives = 178/397 (44%), Gaps = 41/397 (10%)
Query: 344 QQLQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERAN 403
+ +Q+Q+ E+ + +++ E ++ ++RTE ++ A +Q+ E+ER
Sbjct: 1428 EDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLK 1487
Query: 404 K--NCRILQYRLRKAERKRLRYAQTG--EIDGELLRSLEQDLKVAKDVSVRLHHELENVE 459
+ + + + E RL+ Q + + ++ + LKV + RL + E V
Sbjct: 1488 QLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINK-LKVQEQELTRLRIDYERVS 1546
Query: 460 EKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTE 519
++RT + + + + L E+++ KQ ++ EL + LKR S+D K +K E
Sbjct: 1547 QERTVKDQDITRFQNSLKELQLQKQKVEEELNR-----LKRTASEDSCKRKK------LE 1595
Query: 520 EDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGEAGGP 579
E+ E ++ L+ + + +++ + K R E +L++ R LD L + +
Sbjct: 1596 EELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDV---LDGHLREKQ---- 1648
Query: 580 PSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDLRGDDFNGSANPLMREQS 639
T+E LR + E L R++++ E +K LR + F + + ++S
Sbjct: 1649 -RTQE-----ELRRLSSEVEALRRQLLQ---EQESVKQA--HLRNEHFQKA----IEDKS 1693
Query: 640 ESLSELRQHLQLVEDETELLRRNVADLEEQNKRITAELNKYKYKSGGHDSARHHDNAKTE 699
SL+E + ++ ++ TE L + LEE+ + + E Y G A NA
Sbjct: 1694 RSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLE---YDDLRRGRSEADSDKNATIL 1750
Query: 700 ALQEELKAARLQINELSGKVMQLQYENRVLMSNMQRY 736
L+ +L+ + + EL G + LQ E L ++++
Sbjct: 1751 ELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKF 1787
Score = 60.8 bits (146), Expect = 6e-09
Identities = 91/427 (21%), Positives = 187/427 (43%), Gaps = 52/427 (12%)
Query: 344 QQLQEQEEMQEEMEKLREENETLKNEI----DELRTEMDEMRDTFFEEDACQLQEMRHEL 399
Q+ + + ++ ++++L EN LK+EI D + ++ R EE+A Q + E+
Sbjct: 1227 QKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRA--EENALQQKACGSEI 1284
Query: 400 ERANKNCRI-LQYRLRKAERKRLRYAQTGEIDGELLRSLEQD---LKVAKDVSVRLHHEL 455
+ ++ I L+ +++ R+ Q+ E + ++ ++ LK + E
Sbjct: 1285 MQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEY 1344
Query: 456 EN-VEEKRTTTEDENEKLRQQL-IEVEIAKQAL-QNELEKMKELSLKR-------RGSKD 505
EN + + R ++E L+ Q E+ I K + Q ++K ++ S R R ++
Sbjct: 1345 ENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRS 1404
Query: 506 LPKSEKKAQQTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYG 565
L + K+ + T T+ L+ V+E+ + +++ + K + E EL++
Sbjct: 1405 LSEEIKRLKNTLTQTTE-----NLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRT 1459
Query: 566 DLDSPLPKG--EAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDLR 623
+ + +A + E++ +L+++E N RK LE EN L+ DL+
Sbjct: 1460 EESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETN--DRKC--LEDENARLQRVQYDLQ 1515
Query: 624 GDDFNGSANPL---MREQSESLSELRQHLQLVEDETEL-------LRRNVADLEEQNKRI 673
N SA ++ Q + L+ LR + V E + + ++ +L+ Q +++
Sbjct: 1516 --KANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKV 1573
Query: 674 TAELNKYKYKSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVMQL--QYENRVLMS 731
ELN+ K + D+ K + L+EEL+ R + E + K+ L Q E ++
Sbjct: 1574 EEELNRLKRTAS-------EDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVK 1626
Query: 732 NMQRYDL 738
DL
Sbjct: 1627 KRSEDDL 1633
Score = 55.1 bits (131), Expect = 3e-07
Identities = 60/264 (22%), Positives = 113/264 (42%), Gaps = 40/264 (15%)
Query: 332 QAAAPPSSQPHPQQLQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDA-- 389
Q A S+ + E E +Q E L +E+ L+ E+ LR E D++R E D+
Sbjct: 1686 QKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDK 1745
Query: 390 -CQLQEMRHELERANKNCRILQYRLRKAERKRLRYAQTGEIDGELLRSLEQD-------- 440
+ E+R +L+ +N LQ + +R+R Q EI+ ++LE
Sbjct: 1746 NATILELRSQLQISNNRTLELQGLINDLQRERENLRQ--EIEKFQKQALEASNRIQESKN 1803
Query: 441 ---------------LKVAKDVSVRLHHELENVEEKRTTTEDENEKLRQQLIEVEIAKQA 485
+KV + RL + + ++T E E +++Q+L E KQ
Sbjct: 1804 QCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAET-RVKQRL---ECEKQQ 1859
Query: 486 LQNELEKMK-ELSLKRRGSKDLPKSEKKAQQTPTEEDNEDLKCQLQFVKEEAALMRK--- 541
+QN+L + K + S K + + +K+++ +E + Q + + E RK
Sbjct: 1860 IQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLED 1919
Query: 542 ----KMAKIDKEKDRFEHELQKYR 561
++++ E+ R++ E+ K R
Sbjct: 1920 STRETQSQLETERSRYQREIDKLR 1943
Score = 47.0 bits (110), Expect = 8e-05
Identities = 79/379 (20%), Positives = 152/379 (40%), Gaps = 61/379 (16%)
Query: 351 EMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERANKNCRILQ 410
EM + +E L+ +N ++ +ELR D E+ + + + L++ C +
Sbjct: 1019 EMLKSLEDLKLKNTKIEVLEEELRLARDAN-----SENCNKNKFLDQNLQKYQAECSQFK 1073
Query: 411 YRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTTEDENE 470
+L E + + G+ + L +K + RL +E+E+ + +R + ED +
Sbjct: 1074 AKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFD 1133
Query: 471 KLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTEEDNEDLKCQLQ 530
+ + +++ A+Q + L K +SEK ++ E + E L+ LQ
Sbjct: 1134 QQKNDYDQLQKARQCEKENLGWQK------------LESEKAIKE--KEYEIERLRVLLQ 1179
Query: 531 FVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGEAGGPPSTREAELKLR 590
EE R+ ++ K ++ + E+ R+ Y + + + K T E+ ++
Sbjct: 1180 ---EEGTRKREYENELAKVRNHYNEEMSNLRNKY-ETEINITK--------TTIKEISMQ 1227
Query: 591 LRLVEEEANILGRKIVELEVENRGLKAELDDLRGDDFNGSANPLMREQS--------ESL 642
E+++ L ++ L ENR LK E+ L + E++ +
Sbjct: 1228 ---KEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEI 1284
Query: 643 SELRQHL-----QLVEDETELLRRNVADLEEQNKRITAELNKYKYKSGGHDSARHHDNAK 697
+ +QHL Q+++ +E R+ LEE K I D + + K
Sbjct: 1285 MQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTI-------------QDKNKEIERLK 1331
Query: 698 TEALQEELKAARLQINELS 716
E QEE K NELS
Sbjct: 1332 AE-FQEEAKRRWEYENELS 1349
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 75.5 bits (184), Expect = 2e-13
Identities = 105/486 (21%), Positives = 187/486 (38%), Gaps = 51/486 (10%)
Query: 255 LQSELIQFHLKKERAAAAAAAAQMHAKNGGGSSSRSSPVSGPPAVCETLAVASASPMAAA 314
L++EL + +++ A A + + G G SP P + A +P +
Sbjct: 1415 LEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPG----SPARDAPAEGS 1470
Query: 315 AEGPQQSAEGSASGGGMQAAAPPSSQPHPQQLQEQEEMQEEMEKLREENETLKNEIDELR 374
EG + S G + P++ P L + E ++ + + +E + + E DELR
Sbjct: 1471 GEGLNSPSTLECSPGSQPPSPGPATSPASPDL-DPEAVRGALREFLQELRSAQRERDELR 1529
Query: 375 TEMDEMRDTFFEEDACQLQEMRHELERANKNCRILQYRLRKAERKRLRYAQTGEIDGELL 434
T+ + QL EM E + A R LQ + ++E R +DG L
Sbjct: 1530 TQTSALNR--------QLAEMEAERDSATSRARQLQKAVAESEEARR------SVDGRL- 1574
Query: 435 RSLEQDLKVAKDVSVRLHHELENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMK 494
++ +L + ++ SVR E +R T D+ L + L E +A Q ++ KMK
Sbjct: 1575 SGVQAELALQEE-SVR------RSERERRATLDQVATLERSLQATESELRASQEKISKMK 1627
Query: 495 ELSLKRRGSKDLPKSEKKAQQTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFE 554
K G K ++ ++ ++ +K +LQ E L R ++ D+E
Sbjct: 1628 ANETKLEGDK------RRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREA---- 1677
Query: 555 HELQKYRSFYGDLDSPLPKGEA-GGPPSTREAELKLRLRLVEEEANILGRKIVELEVENR 613
+ Q + L + E G L L VEE L K+ L
Sbjct: 1678 -QAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALA 1736
Query: 614 GLKAELDDLRGDDFN--------GSANPLMREQ----SESLSELRQHLQLVEDETELLRR 661
A L+ R + + +++E+ ++LSE R+ + ++ + LR
Sbjct: 1737 QSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRG 1796
Query: 662 NVADLEEQNKRITAELNKYKYKSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVMQ 721
VADLE Q +L + + + LQ+E + + ++ L + Q
Sbjct: 1797 EVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQ 1856
Query: 722 LQYENR 727
L+ E R
Sbjct: 1857 LEAEKR 1862
Score = 68.6 bits (166), Expect = 3e-11
Identities = 117/573 (20%), Positives = 229/573 (39%), Gaps = 103/573 (17%)
Query: 353 QEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQ-LQEMRHELERANKNCR---- 407
Q++ E+LR+E E L+ +ELR + D + + +EDA Q +R ELER+++
Sbjct: 616 QQQAEELRQEREKLQAAQEELRRQRDRLEEE--QEDAVQDGARVRRELERSHRQLEQLEG 673
Query: 408 -------------------ILQYRLRKAER----KRLRYAQTGEIDGEL----LR----S 436
LQ + +AE+ + L A+ G ++ EL LR S
Sbjct: 674 KRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEAS 733
Query: 437 LEQDLKVAKDVSVRLHHELENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKEL 496
L+ L ++ L + ++ E+E L+ + + E + E E+++EL
Sbjct: 734 LQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEEL 793
Query: 497 SLKRRGSKDLPKSEKKAQQTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHE 556
L+ +++ + + E+ E L+ QL ++ E + +++++A++ ++ E E
Sbjct: 794 RLE----QEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQE 849
Query: 557 LQKYRSFYGDLDSPLPKGEAGGPPSTRE-AELKLRLRLVEEEANILGRKIVELEVENRGL 615
L++ R L + +E A L ++L E E L + L +E L
Sbjct: 850 LEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEAL 909
Query: 616 KAELDDLRGD-----------DFNGSANPLMREQ-SESLSELRQHLQLVEDETELLRRNV 663
+ L +++ + G A L +E + L+ LRQ + +++ L + +
Sbjct: 910 EGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELM 969
Query: 664 AD-LEEQNKRITAELNKYKYKSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVMQL 722
A L + + A L + + H+ + EA EL+A R Q+ QL
Sbjct: 970 AQKLVQAEREAQASLREQR---AAHEEDLQRLQREKEAAWRELEAERAQLQS------QL 1020
Query: 723 QYENRVLMSNM--QRYDLASHLGIRGSPRD-------SDAESDAGKKESDDDS------- 766
Q E L++ + ++ +L+ + RD S+ + KES+ +
Sbjct: 1021 QREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMG 1080
Query: 767 ----------RPPHRKREGPIGGESDSEEVR----NIRCLTPTRSFYPAPGPWPKSFSDR 812
+KR+ E D V +R L R A +
Sbjct: 1081 TRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAA--------AHA 1132
Query: 813 QQMKDIRSEAERLGKTIDRLIADTSTIITEARI 845
Q+++ ++ +A LGK D + + + T+ R+
Sbjct: 1133 QEVRRLQEQARDLGKQRDSCLREAEELRTQLRL 1165
Score = 58.2 bits (139), Expect = 4e-08
Identities = 87/386 (22%), Positives = 153/386 (39%), Gaps = 60/386 (15%)
Query: 268 RAAAAAAAAQMHAKNGGGSSSRSSPVSGPPAVCETLAVASASPMAAAAEGPQQSAEGSAS 327
R + A + +M + S + S A+ L A AAA Q+
Sbjct: 1082 RHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRR---- 1137
Query: 328 GGGMQAAAPPSSQPHPQQLQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRD--TFF 385
+Q A + L+E EE++ ++ L + + L+ E+ E + ++ E ++
Sbjct: 1138 ---LQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQ 1194
Query: 386 EEDACQLQEM-------RHELERANKNCRILQYRLRKAERKRLRYAQTGEIDGELLRSLE 438
++A +L+ R L R+N+ L+ ++KAE +R+ E + L LE
Sbjct: 1195 RQEAGELRRSLGEGAKEREALRRSNEE---LRSAVKKAESERISLKLANEDKEQKLALLE 1251
Query: 439 QDLKVAKDVSVRLHHELENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMK-ELS 497
+ + L L+ VE R E ++LR+Q+ ++ L EL +++ L+
Sbjct: 1252 EARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLA 1311
Query: 498 LKRRGSKDLPKSEKKAQQTPTEEDNEDLKCQLQFVKEEAAL--MRKKMAKIDKEKDRFEH 555
L R K E E L + + +K EA+L MR+++ ++ E
Sbjct: 1312 LGERAEK--------------ESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEG 1357
Query: 556 ELQ-KYRSFYGDLDSPLPKGEAGGPPS-----------------TREAELKLRLRLVEEE 597
E + + R G L+ EA G AEL LRL E
Sbjct: 1358 EFRTRERRLLGSLE------EARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGR 1411
Query: 598 ANILGRKIVELEVENRGLKAELDDLR 623
A L ++ +EV+ R +A+L LR
Sbjct: 1412 AQGLEAELARVEVQRRAAEAQLGGLR 1437
Score = 58.2 bits (139), Expect = 4e-08
Identities = 151/732 (20%), Positives = 284/732 (38%), Gaps = 93/732 (12%)
Query: 37 QRAQSPARPRDSSLRQTIAATRSPVGAGTKLNSVRQQQLQQQQQQGNKTGSRT-GPPASI 95
+RA+ +R LRQ + + + + V Q++LQ+Q+ + R G
Sbjct: 1314 ERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEA 1373
Query: 96 RGGGGGAEKATPLAPKGAAPGAVQPVAGAEAAPAAT-LAALGGRRPGPPEEPPRELESVP 154
RG EK +G A AEAA L+A GR G E R V
Sbjct: 1374 RG----TEKQQLDHARGLE--LKLEAARAEAAELGLRLSAAEGRAQGLEAELARV--EVQ 1425
Query: 155 SKLGEPPPLGEGGGGGGEGGGAGGGSGEREGGAPQPPPPRGWRGKGVRAQQRGGSGGEGA 214
+ E GG G G G AP+P P G R GSG
Sbjct: 1426 RRAAEAQL-----GGLRSALRRGLGLGRAPSPAPRPVP-----GSPARDAPAEGSGEGLN 1475
Query: 215 SPSPSSSSAGK---TPGTGSRNSGSGVAGGGSGGGGSYWKEGCLQSELIQFHLKKERAAA 271
SPS S G +PG + + + G + + ++ + L+ + +A
Sbjct: 1476 SPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSAL 1535
Query: 272 AAAAAQMHAKNGGGSSSRSSPVSGPPAVCETLAVASASPMAAAAEGPQQSAEGSASGGGM 331
A+M A+ +S A +E ++S +G SG
Sbjct: 1536 NRQLAEMEAERDSATS----------------RARQLQKAVAESEEARRSVDGRLSGVQA 1579
Query: 332 QAAAPPSSQPHPQQLQE---------QEEMQEEMEKLREENETL-KNEIDELRTEMDEMR 381
+ A S ++ + + +Q +LR E + K + +E + E D+ R
Sbjct: 1580 ELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRR 1639
Query: 382 DTFFEE--DACQLQEMRHELERANKNCRILQYRLRKAERKRLRYAQTGEIDGELLRSLEQ 439
+E DA + + ++ EL+R + + + RL ++R+ A +D + +
Sbjct: 1640 ---LKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADS 1696
Query: 440 DLKVAK-DVSV-RLHHELENVEEKR---------------------TTTEDENEKLRQQL 476
++K ++V RL+ L VEE +T D+N L++ L
Sbjct: 1697 EVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKAL 1756
Query: 477 IEVEIAKQALQNELEKMKE-LSLKRRGSKDLPKSEK--KAQQTPTEEDNEDLKCQLQFVK 533
E +Q LQ L+ ++ LS R+ S L + + + + E + + QLQ ++
Sbjct: 1757 TACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLR 1816
Query: 534 EEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGEAGGPPSTREAELKLRLRL 593
E ++ A + + E + + G L L + EA RE E + LRL
Sbjct: 1817 EVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEA----EKREVE-RSALRL 1871
Query: 594 VEEEANILGRKIVELEVENRGLKAELDDLRGDDFNGSANPLMREQSESLSELRQHLQLVE 653
E+ + R+ ++ +VE L++ D +R G + + L+E ++ +Q +E
Sbjct: 1872 --EKDRVALRRTLD-KVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLE 1928
Query: 654 DETELLRRNVA----DLEEQNKRITAELNKYKYKSGGHDSARHHDNAKTEALQEELKAAR 709
+ +L ++ + +++ Q +++ + + +S + R + A+ A ++ ++
Sbjct: 1929 AQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLE-ARERAHRQRVRGLE 1987
Query: 710 LQINELSGKVMQ 721
Q++ L G++ Q
Sbjct: 1988 EQVSTLKGQLQQ 1999
Score = 55.8 bits (133), Expect = 2e-07
Identities = 110/511 (21%), Positives = 192/511 (37%), Gaps = 118/511 (23%)
Query: 305 VASASPMAAAAEGPQQSAEGSASGGGMQAAAPPSSQPHPQQLQEQEEMQEE-----MEKL 359
VA +A +G Q+ AE +A Q ++L+ ++E+ + +
Sbjct: 759 VAQLEEEKSALQGRQRQAE-------QEATVAREEQERLEELRLEQEVARQGLEGSLRVA 811
Query: 360 REENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERANKNCRILQYRLRKAERK 419
+ E L+ ++ LR E ++++ + QL ELE+A + + L +A R+
Sbjct: 812 EQAQEALEQQLPTLRHERSQLQEQLAQLSR-QLSGREQELEQARREAQRQVEALERAARE 870
Query: 420 RLRYAQ----------TGEIDGELLRSLEQDLKVAKDVS----VRLHHELENVEEKRTTT 465
+ A+ E +G L L++ K+ + +L +E +R
Sbjct: 871 KEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQL 930
Query: 466 EDENEKL--------------RQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKS-- 509
E E + L RQQ+I + K +L EL K + +R L +
Sbjct: 931 EAEGQALLLAKETLTGELAGLRQQIIATQ-EKASLDKELMAQKLVQAEREAQASLREQRA 989
Query: 510 -----------EKKAQQTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQ 558
EK+A E + L+ QLQ +EE +A+++ EK+ E+
Sbjct: 990 AHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEEL------LARLEAEKEELSEEIA 1043
Query: 559 KYRSFYGDLDSPLPKGEAGGPPSTREAELKLRLRLVEEEANILGRKI---------VELE 609
+ + D L E+E + L L E E L K+ + LE
Sbjct: 1044 ALQQ---ERDEGL---------LLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLE 1091
Query: 610 VENR----------------GLKAELDDLRGDDFNGSANPL-----MREQSESLS----- 643
+E + L +EL DLR +A ++EQ+ L
Sbjct: 1092 MERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDS 1151
Query: 644 ------ELRQHLQLVEDETELLRRNVADLEEQNK-RITAELNKYKYKSGGHDSARHHDNA 696
ELR L+L+ED + LRR + LE Q K R + E + + + G + A
Sbjct: 1152 CLREAEELRTQLRLLEDARDGLRREL--LEAQRKLRESQEGREVQRQEAGELRRSLGEGA 1209
Query: 697 K-TEALQEELKAARLQINELSGKVMQLQYEN 726
K EAL+ + R + + + + L+ N
Sbjct: 1210 KEREALRRSNEELRSAVKKAESERISLKLAN 1240
Score = 46.2 bits (108), Expect = 1e-04
Identities = 113/500 (22%), Positives = 199/500 (39%), Gaps = 60/500 (12%)
Query: 348 EQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEE-DACQLQEMRHELERANKNC 406
EQ E E +E L + ELR ++ E + ++ + A Q + R
Sbjct: 119 EQALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQG 178
Query: 407 RILQYRLRKAERKRLRYAQTGEIDGELLRSLE--QDLKVAKDVSVRLHHELENVEEKRTT 464
+ILQY+ R +E ++ ++GE++ + LR E QDL+ A +RL E +++ +
Sbjct: 179 KILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESAL---IRLEEE----QQRSAS 231
Query: 465 TEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTEEDNED 524
N LR+QL + A QAL ++ K+ + D + K+ + E+
Sbjct: 232 LAQVNAMLREQLDQAGSANQALSEDIRKV---------TNDWTRCRKELEHREAAWRREE 282
Query: 525 LKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGE-AGGPPSTR 583
F E + L+ + ++ F + + + F + D GE A + +
Sbjct: 283 ESFNAYFSNEHSRLL-----LLWRQVVGFRRLVSEVKMF-TERDLLQLGGELARTSRAVQ 336
Query: 584 EAELKLR--LRLVEEEANILGRKIVELEVENRG-LKAELDDLRGDDFNGSANPLMREQSE 640
EA L L LRL E A E +E + L+A+L++ D + ++
Sbjct: 337 EAGLGLSTGLRLAESRA--------EAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQS 388
Query: 641 SLSELRQHLQLVEDETELLRRNVADLEEQ--NKRITAELNKYKYKSGGHDSARHHDNAKT 698
L + ++ E + R +LE+ NK +T +L +S R + A
Sbjct: 389 DLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEAL-------ESLRLQEQAAL 441
Query: 699 EALQEELKAARLQINELSGKVMQLQYENRVLMSNMQRYDLASHLGIRGSPRDSDAESDAG 758
E E+ + + + +L+ V+ E+ V +S +R AS+ +RG
Sbjct: 442 ET--EDGEGLQQTLRDLAQAVLS-DSESGVQLSGSERTADASNGSLRG--LSGQRTPSPP 496
Query: 759 KKESDDDSRPPHRKREGPIGGESDSEEVRNIRCLTPTRSF--YPAPGPWPKS----FSDR 812
++ S R P R GP SDS + I R G + S + R
Sbjct: 497 RRSSPGRGRSP---RRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLR 553
Query: 813 QQMKDIRSEAERLGKTIDRL 832
+Q+ D SE L + + RL
Sbjct: 554 KQLSDSESERRALEEQLQRL 573
Score = 43.1 bits (100), Expect = 0.001
Identities = 78/439 (17%), Positives = 178/439 (40%), Gaps = 69/439 (15%)
Query: 353 QEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERANKNCRILQYR 412
+ E E+ L+ +++E ++RD E Q+M+ +L++A+ + R+ +
Sbjct: 350 ESRAEAALEKQALLQAQLEE------QLRDKVLREKDLAQQQMQSDLDKADLSARVTELG 403
Query: 413 L--RKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVR------LHHELENVEEKRTT 464
L ++ E++ L Q + E L +LE L++ + ++ L L ++ + +
Sbjct: 404 LAVKRLEKQNLEKDQVNKDLTEKLEALES-LRLQEQAALETEDGEGLQQTLRDLAQAVLS 462
Query: 465 TEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTEEDN-- 522
+ +L + + +L+ L + S RR S +S ++ + +
Sbjct: 463 DSESGVQLSGSERTADASNGSLRG-LSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTL 521
Query: 523 --------------EDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYR------- 561
+D++ + + ++ +RK+++ + E+ E +LQ+ R
Sbjct: 522 ALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAM 581
Query: 562 SFYGDLDSPLPKGEAGGPPSTRE-AELKLRLRLVEEEANILGRKIVELEVENRGLKAELD 620
+ D + + + +RE + L L++ +++A L ++ +L+ L+ + D
Sbjct: 582 QAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRD 641
Query: 621 DL--RGDDFNGSANPLMREQSES-----------------LSELRQHLQLVEDETELLRR 661
L +D + RE S L E+R+ L + ++L+
Sbjct: 642 RLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQA 701
Query: 662 NVADLEE-----QNKRITAELNKYKYKSGGHDSARHHDNAKTEALQEELKAARLQINELS 716
A++ E + R+ EL+ K ++ +++ +K AL E L +L +N L
Sbjct: 702 EKAEVAEALTKAEAGRVELELSMTKLRA--EEASLQDSLSKLSALNESLAQDKLDLNRL- 758
Query: 717 GKVMQLQYENRVLMSNMQR 735
V QL+ E L ++
Sbjct: 759 --VAQLEEEKSALQGRQRQ 775
>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
Length = 1780
Score = 75.1 bits (183), Expect = 3e-13
Identities = 88/402 (21%), Positives = 176/402 (43%), Gaps = 62/402 (15%)
Query: 350 EEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERANKNCRIL 409
EE+++++EKL+ E + K+E + L+ + + +D +E +Q+++ EL+ N +
Sbjct: 1039 EELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDV- 1097
Query: 410 QYRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTTEDEN 469
++++ G+ L L Q + K ++ ELE + E + +
Sbjct: 1098 ----------QIQHVVEGK---RALSELTQGVTCYK-AKIK---ELETILETQKVECSHS 1140
Query: 470 EKLRQQLIEVEIAKQALQNELEKMKE-LSLKRRGSKDLPKSEKKAQQTPTEEDN--EDLK 526
KL Q ++E E L+ L++ +E L + +KDL E K ++ T+ N +D+K
Sbjct: 1141 AKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMK 1200
Query: 527 CQLQFVKEEAALMRKKMAKIDKE-------KDRFEHELQKYRSFYGDLDSPLPKGEAGGP 579
LQ +EE R++ K+ +E + +LQ+ Y DL L +
Sbjct: 1201 HLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAK---- 1256
Query: 580 PSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELD-------DLRGDDFNGSAN 632
+ +++ + ++ +E +L KI ELE + ELD L+ N
Sbjct: 1257 --KQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVE 1314
Query: 633 PLMREQSESLSELRQHLQLVED---------ETELLRRNVADLE-EQNKRITAELNKYKY 682
+++ + +L +++ED +T++ + V + + E+ +R+ EL K+K
Sbjct: 1315 EAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKE 1374
Query: 683 K------SGGHDSARHHDN-----AKTEALQEELKAARLQIN 713
K S + H+N K LQ+EL+ + + N
Sbjct: 1375 KCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYN 1416
Score = 42.0 bits (97), Expect = 0.003
Identities = 75/398 (18%), Positives = 164/398 (41%), Gaps = 62/398 (15%)
Query: 353 QEEMEKLREENETLKNEIDELRTEMD------EMRDTFFEEDACQLQEMRHELERANKNC 406
Q+E+ ++N TL E+ ++++ D ++ + +E ++ ++ +E+E A ++
Sbjct: 876 QQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSI 935
Query: 407 --RILQYRLRKAERKRLR----YAQTGEIDGELLRSL----EQDLKVAKDVSVRLHHELE 456
+ Q +L + LR +Q ID LR L E+D + + + L
Sbjct: 936 TNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLV 995
Query: 457 NVEEKRTTTEDEN---------EKLRQQLIEVEIAKQALQNELEKMKE----LSLKRRGS 503
+ + K ++ N E + ++ E+ A +++E++++ L + +G
Sbjct: 996 SKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGY 1055
Query: 504 KDLPKSEKKAQQTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSF 563
KD K+ + ++ ++ + +Q +KEE +++K +D + +H ++ R+
Sbjct: 1056 KDENNRLKEKEHKNQDDLLKEKETLIQQLKEE---LQEKNVTLDVQ---IQHVVEGKRAL 1109
Query: 564 YGDLDSPLPKGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDLR 623
S L +G +E E L + VE + K E D L
Sbjct: 1110 -----SELTQGVTCYKAKIKELETILETQKVEC---------------SHSAKLEQDILE 1149
Query: 624 GDDFNGSANPLMREQSESLSELRQHLQLVEDETELLRRNVADLEEQNKRITAELNKYKYK 683
+ ++ + +L E ++HLQ T+ L L+E+ ++T L K+
Sbjct: 1150 KES-------IILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHL 1202
Query: 684 SGGHDSARHHDNAKTEALQEELKAARLQINELSGKVMQ 721
+ + +TE L+EEL A+ + L + +
Sbjct: 1203 LQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQR 1240
Score = 40.8 bits (94), Expect = 0.006
Identities = 63/385 (16%), Positives = 157/385 (40%), Gaps = 19/385 (4%)
Query: 344 QQLQEQEEMQEEMEKLREENETLKNEIDE-LRTEMDEMRDTFFEEDACQL----QEMRHE 398
+ L E E++ EE+E E +DE L ++E + E+ +L ++++ +
Sbjct: 527 EDLMEDEDLVEELENAEETQNVETKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLKKK 586
Query: 399 LERANKNCRILQYRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENV 458
L K L++++R+ + + + + +L Q+ ++ ++ + R +++
Sbjct: 587 LINEKKEKLTLEFKIREEVTQEFT-QYWAQREADFKETLLQEREILEENAERRLAIFKDL 645
Query: 459 EEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPT 518
K T E+ + + +E E A L+ + ++K K +G K E K +
Sbjct: 646 VGKCDTREEAAKDICATKVETEEATACLELKFNQIKAELAKTKGELIKTKEELKKR---- 701
Query: 519 EEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGEAGG 578
E +++ L +L+ ++ +++ ++ D+ E + ++++ +++ +
Sbjct: 702 ENESDSLIQELETSNKKIITQNQRIKELINIIDQKEDTINEFQNLKSHMENTFKCNDKAD 761
Query: 579 PPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDLRGDDFNGSANPLMREQ 638
S + VE + + E + N + + D+ + + + E
Sbjct: 762 TSSLIINNKLICNETVEVPKDSKSKICSERKRVNEN-ELQQDEPPAKKGSIHVSSAITED 820
Query: 639 SESLSELRQHLQLVEDETELLRRNVADLEEQNKRITAELNKYKYKSGGHDSARHHDNAKT 698
+ E+R ++ +ED + L+E N+ + A L + + + N +
Sbjct: 821 QKKSEEVRPNIAEIED--------IRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQI 872
Query: 699 EALQEELKAARLQINELSGKVMQLQ 723
Q+EL + + LS +V Q+Q
Sbjct: 873 VHFQQELSLSEKKNLTLSKEVQQIQ 897
Score = 40.8 bits (94), Expect = 0.006
Identities = 91/458 (19%), Positives = 192/458 (41%), Gaps = 77/458 (16%)
Query: 340 QPHPQQLQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRD--TFFEED--------- 388
+P+ ++++ +QE E LR T++NE+ + E E+ F+++
Sbjct: 828 RPNIAEIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNL 887
Query: 389 --ACQLQEMRHELERANKNCRILQYRLRKAERKRLRYAQTGEI----------DGELLRS 436
+ ++Q+++ + A + + + ++ E K ++ + E +L+ +
Sbjct: 888 TLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHT 947
Query: 437 LEQDLKVAKDVSVRLHHELENVEEKRTTTEDEN------------EKLRQQLIEVEIAKQ 484
+L+ VS + +L N+ + +E++N + +Q+ E I +
Sbjct: 948 KIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEP 1007
Query: 485 ALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTEEDNEDLKCQLQFVKEEAALMRKKMA 544
+N E + S+K Q E+ E L+ +++ K+E +++K
Sbjct: 1008 NRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEH 1067
Query: 545 K----IDKEKD----RFEHELQKYRSFYGDLD-----------SPLPKGEAGGPPSTREA 585
K + KEK+ + + ELQ+ ++ D+ S L +G +E
Sbjct: 1068 KNQDDLLKEKETLIQQLKEELQE-KNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKEL 1126
Query: 586 ELKLRLRLVE------EEANILGRKIVELEVENRGLKAELDDLRGD-----DFNGSANPL 634
E L + VE E +IL ++ + L++E R LK + L+ D N L
Sbjct: 1127 ETILETQKVECSHSAKLEQDILEKESIILKLE-RNLKEFQEHLQDSVKNTKDLNVKELKL 1185
Query: 635 MREQSE---SLSELRQHLQLVEDETELLRRNVADLEEQNKRITAELNKYKYKSGGHDSAR 691
E ++ +L +++ LQL E+E E R+ L+E+ +A K D R
Sbjct: 1186 KEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLK-----ADLQR 1240
Query: 692 HHDNAKTEALQEELKAARLQINELSGKVMQLQYENRVL 729
++ L+E+L A+ QI ++ +V ++ E+++L
Sbjct: 1241 KEEDYAD--LKEKLTDAKKQIKQVQKEVSVMRDEDKLL 1276
Score = 32.7 bits (73), Expect = 1.6
Identities = 42/182 (23%), Positives = 83/182 (45%), Gaps = 21/182 (11%)
Query: 331 MQAAAPPSSQPHPQQLQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDA- 389
M+ Q +Q Q E EE+E+L E E K + ++L T+ ++ + E +
Sbjct: 1337 MRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTD 1396
Query: 390 --CQLQEMRHELERANKNCRILQYRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDV 447
+L ++ EL+ + + + R + E K + Q E E +R+ E K A+D
Sbjct: 1397 VLGKLTNLQDELQESEQ--KYNADRKKWLEEKMMLITQAKE--AENIRNKEMK-KYAEDR 1451
Query: 448 S--VRLHHELENVEEKRTTTEDENEKLRQQ----LIEVEIAKQAL-------QNELEKMK 494
+ +E+E + + T + + +K R++ + +EI +AL NE+E++K
Sbjct: 1452 ERFFKQQNEMEILTAQLTEKDSDLQKWREERDQLVAALEIQLKALISSNVQKDNEIEQLK 1511
Query: 495 EL 496
+
Sbjct: 1512 RI 1513
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 74.7 bits (182), Expect = 4e-13
Identities = 91/378 (24%), Positives = 162/378 (42%), Gaps = 28/378 (7%)
Query: 344 QQLQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERAN 403
QQ E E +EE E+ E + NE LR + +E+ ++ + E + E A
Sbjct: 1615 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA----QQKSLAQAEAEKQKEEAE 1670
Query: 404 KNCRILQYRLRKAERKRLRYAQTGEIDGELLRSLE----QDLKVAKDVSVRLHHELENVE 459
+ R R KAE + +R + E + E R L Q A+ +RL E E E
Sbjct: 1671 REAR----RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1726
Query: 460 EKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTE 519
++R E+E +L+++ +Q L+ EL K++ SK + E ++ ++
Sbjct: 1727 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1786
Query: 520 EDNEDLKCQLQFVKEEAALMR---------KKMAKIDKEKDRFEHELQKYRSFYGDLDSP 570
+ E + + + EEAA +R +++A+ D + R E E ++
Sbjct: 1787 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1846
Query: 571 LPKGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDLRGDDFNGS 630
K EA +EAE + RL E+EA R++ E ++ KA++++ S
Sbjct: 1847 RLKTEAEIALKEKEAENERLRRLAEDEA-FQRRRLEEQAAQH---KADIEERLAQLRKAS 1902
Query: 631 ANPLMREQSESLSELRQHLQLVEDETELLRRNVADLEEQNKRITAELNKYKYKSGGHDSA 690
+ L R++ LRQ Q+ E E+L + + + EL + +S D+
Sbjct: 1903 DSELERQKGLVEDTLRQRRQV---EEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1959
Query: 691 RHHDNAKTEALQEELKAA 708
R + A+ EA ++ AA
Sbjct: 1960 RSKEQAELEAARQRQLAA 1977
Score = 65.1 bits (157), Expect = 3e-10
Identities = 117/559 (20%), Positives = 225/559 (40%), Gaps = 118/559 (21%)
Query: 313 AAAEGPQQSAEGSASGGGMQAAAPPSSQPHPQQLQEQEEMQEEME-KLREENETLKNEID 371
AA E +Q AE A +A A ++ Q++QE+ +EE +++ +++ E+
Sbjct: 1367 AALEKQRQLAEAHAQA---KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ 1423
Query: 372 ELRTEMD-EMRDTFFEEDACQLQEMRHELERANKNCRILQYRLRKAERKRLRYAQTGEID 430
+LR + E++ + +A + +R E E R+++ +L ER+R G +
Sbjct: 1424 QLRQSSEAEIQAKARQAEAAERSRLRIEEE-----IRVVRLQLEATERQR------GGAE 1472
Query: 431 GELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTTEDENEKLRQQL---------IEVEI 481
GEL L E E ++ ++E E+LR+Q+ EVE+
Sbjct: 1473 GELQA---------------LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1517
Query: 482 AK----------------QAL---------------QNELEKMKELSLKRRGSKDLPKSE 510
A QAL Q E+E+ +++ + ++ ++E
Sbjct: 1518 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1577
Query: 511 KKAQQTPTEEDNEDLKCQLQ-------FVKEEAALMRKKMAKIDKEKDRFEHELQKY--- 560
++++ E L+ LQ ++EEA ++ A+ ++ ++ E EL+++
Sbjct: 1578 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1637
Query: 561 -------RSFYGDLDSPLPKGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENR 613
R ++ +A EAE + R R EE + R++ E E+E +
Sbjct: 1638 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1697
Query: 614 ------------GLKAELDDLRGDDFNGSANPLMREQ------------SESLSELRQHL 649
+ EL LR + G + E+ ++ EL L
Sbjct: 1698 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1757
Query: 650 QLVEDETELLRRNVADLEEQNKRITAELNKYKYKS-GGHDSARHHDNAKTEALQEELKAA 708
V E E+L + A EE++ R T+E +K + ++ G + A+ AL EE K
Sbjct: 1758 AKVRAEMEVLLASKARAEEES-RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1816
Query: 709 RLQINELSGKVMQLQYENRVLMSNMQRYDLASHLGIRG--SPRDSDAESDAGKKESDDDS 766
R E + + Q RVL + A+ L + ++ +AE++ ++ ++D++
Sbjct: 1817 RQLAEEDAAR--QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1874
Query: 767 RPPHRKREGPIGGESDSEE 785
R E ++D EE
Sbjct: 1875 FQRRRLEEQAAQHKADIEE 1893
Score = 64.7 bits (156), Expect = 4e-10
Identities = 90/418 (21%), Positives = 178/418 (42%), Gaps = 60/418 (14%)
Query: 344 QQLQEQEEMQEEMEKLRE----ENETLKNEIDELRTEMDEMRDTF------FEEDACQLQ 393
Q Q + +++E + +LR+ E E K +++ + ++ + FE+ A
Sbjct: 1883 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1942
Query: 394 EMRHELERANKNCRILQYRLRKAERKRLRYAQTGEIDGEL-LRSLEQDLKVAKDVSVRLH 452
E+ EL R N + LR E+ L A+ ++ E R E + +V K ++
Sbjct: 1943 ELELELGRIRSNA---EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE-- 1997
Query: 453 HELENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKK 512
E +R +E E+L+ ++ E ++ + E E ++L L + ++ ++E+K
Sbjct: 1998 ---EEAARQRKAALEEVERLKAKVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEK 2052
Query: 513 AQQTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLP 572
A ++ ++L+ LQ +E++ L D+ E + R + +
Sbjct: 2053 AHAFAVQQKEQELQQTLQ--QEQSVL------------DQLRGEAEAARRAAEEAEEARV 2098
Query: 573 KGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDLRGDDFNGSAN 632
+ E S R+ E RL+ EE R + E +AE + R +A
Sbjct: 2099 QAEREAAQSRRQVEEAERLKQSAEE-QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA- 2156
Query: 633 PLMREQSESLSELRQHLQL----------VEDETELLRRNVADLEEQNKRITAELNKYKY 682
+R++ + +E+ +H + VE E LR + + + Q + EL + K
Sbjct: 2157 --LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2214
Query: 683 KSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVMQLQYENRVLM----SNMQRY 736
++ ++AR ++EEL + R+Q+ ELS +++ ENR L+ N QR+
Sbjct: 2215 EAT--EAARQRSQ-----VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2265
Score = 62.4 bits (150), Expect = 2e-09
Identities = 93/427 (21%), Positives = 177/427 (41%), Gaps = 82/427 (19%)
Query: 344 QQLQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERAN 403
Q +QE ++ E E L+++ E + + L+ + ++M A QL E +R
Sbjct: 2317 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM--------AQQLAEETQGFQRTL 2368
Query: 404 KNCRILQYRLR-KAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHE-------- 454
+ R Q + +AER +LR A+ ++ K A+++ +LH
Sbjct: 2369 EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2428
Query: 455 --LENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKK 512
++ +E +R ++ + E+LR+ + E+E K+ LQ E K L LK + + + E+
Sbjct: 2429 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE---AKLLQLKSEEMQTV-QQEQL 2484
Query: 513 AQQTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLP 572
Q+T Q F+ E+ +L++++ I++EK + E Q
Sbjct: 2485 LQETQA--------LQQSFLSEKDSLLQRERF-IEQEKAKLEQLFQD------------- 2522
Query: 573 KGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDLRGDDFNGSAN 632
E+ +L EE+ R+ ++E E + L A +++ R A
Sbjct: 2523 -------------EVAKAQQLREEQQ----RQQQQMEQERQRLVASMEEARRRQH--EAE 2563
Query: 633 PLMREQSESLSEL----RQHLQLVEDETELLRRNVADLEEQNKRITA--------ELNKY 680
+R + E L +L RQ +L+ +E + LR + LEEQ++ A ++
Sbjct: 2564 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2623
Query: 681 KYKSGGHD-----SARHHDNAKTEALQEELKAARLQ-INELSGKVMQLQYENRVLMSNMQ 734
K G D +A + L+ ++ A RLQ LS + +Q + + +
Sbjct: 2624 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELA 2683
Query: 735 RYDLASH 741
R + H
Sbjct: 2684 RREDVRH 2690
Score = 58.5 bits (140), Expect = 3e-08
Identities = 113/541 (20%), Positives = 215/541 (39%), Gaps = 87/541 (16%)
Query: 268 RAAAAAAAAQMHAKNGGGSSSRS-SPVSGPPAVCETLAVASASPMAAAA----EGPQQSA 322
RAA A A++ A+ S R E A A A AAA E Q++A
Sbjct: 2088 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2147
Query: 323 ---EGSASGGGMQAAAPPSSQPHP----QQLQEQEEMQEEMEKLR---EENETLKNEIDE 372
+ + + AA + H Q L+++ ++++E+ LR EE + KN +DE
Sbjct: 2148 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2207
Query: 373 L-------RTEMDEMRDTFFEE------DACQLQEMRHELERANKNC---------RILQ 410
TE R EE +L +++ +E N+ R LQ
Sbjct: 2208 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2267
Query: 411 Y---RLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTTED 467
++++ + R + + L + E+DL + ++ ++ E ++ T +
Sbjct: 2268 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2327
Query: 468 ENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTEEDNEDLKC 527
E E L+QQ + + LQ + E+M ++ L + + Q+T E L+
Sbjct: 2328 EAELLQQQKELAQEQARRLQEDKEQM---------AQQLAEETQGFQRTLEAERQRQLE- 2377
Query: 528 QLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGE-AGGPPSTREAE 586
+ EA ++ ++A++ + + R E + Q++R ++ L + E A T
Sbjct: 2378 ----MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2433
Query: 587 LKLRLRLVEEEANILGRKIVELEVENRGL--KAELDDLRGDDFNGSANPLMREQSESLSE 644
L+++ + + +A L I ELE E L +A+L L+ ++ + +++++L +
Sbjct: 2434 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2493
Query: 645 --------LRQHLQLVEDETELL------------------RRNVADLEEQNKRITAELN 678
L Q + +E E L +R +E++ +R+ A +
Sbjct: 2494 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2553
Query: 679 KYKYKSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVMQLQYENRVLMSNMQRYDL 738
+ + + A K E LQ +L+ R Q EL + Q E L+ R L
Sbjct: 2554 EARRR---QHEAEEGVRRKQEELQ-QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2609
Query: 739 A 739
A
Sbjct: 2610 A 2610
Score = 47.0 bits (110), Expect = 8e-05
Identities = 86/434 (19%), Positives = 188/434 (43%), Gaps = 56/434 (12%)
Query: 358 KLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERANKNCRILQYRLRKAE 417
K++ +E++ E +LRT E+ + ++ + L R + R+ + + R E
Sbjct: 1304 KVQSGSESVIQEYVDLRTHYSELTTLTSQ----YIKFISETLRRMEEEERLAEQQ-RAEE 1358
Query: 418 RKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTTEDENEKLRQQLI 477
R+RL E+ +LE+ ++A+ + +E + ++E + + +
Sbjct: 1359 RERL---------AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1409
Query: 478 EVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTEEDNEDLKCQLQFVKEEAA 537
+ + K+++Q EL+++++ S + + KA+Q E + +L+ ++EE
Sbjct: 1410 DAQQQKRSIQEELQQLRQSS--------EAEIQAKARQAEAAE-----RSRLR-IEEEIR 1455
Query: 538 LMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGEAGGPPSTREAELKLRLRLVEEE 597
++R ++ ++++ E ELQ R + + EA + EAE +LR R V++E
Sbjct: 1456 VVRLQLEATERQRGGAEGELQALR-------ARAEEAEAQKRQAQEEAE-RLR-RQVQDE 1506
Query: 598 ANILGRKIVELEVENRGLKAELDDLRGDDFNGSANPLMREQSESLSELRQHLQLVEDETE 657
+ ++ E+E+ +R +KAE + R A +R Q+E +L + E E
Sbjct: 1507 SQ--RKRQAEVELASR-VKAEAEAAREKQRALQALEELRLQAEEAER-----RLRQAEVE 1558
Query: 658 LLRRNVADLEEQNKRITAELNKYKYKSGGHDSARHHDNAKTEALQEELKAARLQINELSG 717
R+ LE + AEL + ++ A+ E +E A Q+ E +
Sbjct: 1559 RARQVQVALETAQRSAEAELQSKR-------ASFAEKTAQLERSLQEEHVAVAQLREEAE 1611
Query: 718 KVMQLQYE----NRVLMSNMQRYDLASHLGIRGSPRDSDAESDAGKKESDDDSRPPHRKR 773
+ Q Q E ++R+ L ++ +R + + +++ + + +R
Sbjct: 1612 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1671
Query: 774 EGPIGGESDSEEVR 787
E G+++ + VR
Sbjct: 1672 EARRRGKAEEQAVR 1685
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 74.7 bits (182), Expect = 4e-13
Identities = 91/378 (24%), Positives = 162/378 (42%), Gaps = 28/378 (7%)
Query: 344 QQLQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERAN 403
QQ E E +EE E+ E + NE LR + +E+ ++ + E + E A
Sbjct: 1619 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA----QQKSLAQAEAEKQKEEAE 1674
Query: 404 KNCRILQYRLRKAERKRLRYAQTGEIDGELLRSLE----QDLKVAKDVSVRLHHELENVE 459
+ R R KAE + +R + E + E R L Q A+ +RL E E E
Sbjct: 1675 REAR----RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1730
Query: 460 EKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTE 519
++R E+E +L+++ +Q L+ EL K++ SK + E ++ ++
Sbjct: 1731 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1790
Query: 520 EDNEDLKCQLQFVKEEAALMR---------KKMAKIDKEKDRFEHELQKYRSFYGDLDSP 570
+ E + + + EEAA +R +++A+ D + R E E ++
Sbjct: 1791 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1850
Query: 571 LPKGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDLRGDDFNGS 630
K EA +EAE + RL E+EA R++ E ++ KA++++ S
Sbjct: 1851 RLKTEAEIALKEKEAENERLRRLAEDEA-FQRRRLEEQAAQH---KADIEERLAQLRKAS 1906
Query: 631 ANPLMREQSESLSELRQHLQLVEDETELLRRNVADLEEQNKRITAELNKYKYKSGGHDSA 690
+ L R++ LRQ Q+ E E+L + + + EL + +S D+
Sbjct: 1907 DSELERQKGLVEDTLRQRRQV---EEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1963
Query: 691 RHHDNAKTEALQEELKAA 708
R + A+ EA ++ AA
Sbjct: 1964 RSKEQAELEAARQRQLAA 1981
Score = 65.1 bits (157), Expect = 3e-10
Identities = 117/559 (20%), Positives = 225/559 (40%), Gaps = 118/559 (21%)
Query: 313 AAAEGPQQSAEGSASGGGMQAAAPPSSQPHPQQLQEQEEMQEEME-KLREENETLKNEID 371
AA E +Q AE A +A A ++ Q++QE+ +EE +++ +++ E+
Sbjct: 1371 AALEKQRQLAEAHAQA---KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ 1427
Query: 372 ELRTEMD-EMRDTFFEEDACQLQEMRHELERANKNCRILQYRLRKAERKRLRYAQTGEID 430
+LR + E++ + +A + +R E E R+++ +L ER+R G +
Sbjct: 1428 QLRQSSEAEIQAKARQAEAAERSRLRIEEE-----IRVVRLQLEATERQR------GGAE 1476
Query: 431 GELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTTEDENEKLRQQL---------IEVEI 481
GEL L E E ++ ++E E+LR+Q+ EVE+
Sbjct: 1477 GELQA---------------LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1521
Query: 482 AK----------------QAL---------------QNELEKMKELSLKRRGSKDLPKSE 510
A QAL Q E+E+ +++ + ++ ++E
Sbjct: 1522 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1581
Query: 511 KKAQQTPTEEDNEDLKCQLQ-------FVKEEAALMRKKMAKIDKEKDRFEHELQKY--- 560
++++ E L+ LQ ++EEA ++ A+ ++ ++ E EL+++
Sbjct: 1582 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1641
Query: 561 -------RSFYGDLDSPLPKGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENR 613
R ++ +A EAE + R R EE + R++ E E+E +
Sbjct: 1642 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1701
Query: 614 ------------GLKAELDDLRGDDFNGSANPLMREQ------------SESLSELRQHL 649
+ EL LR + G + E+ ++ EL L
Sbjct: 1702 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1761
Query: 650 QLVEDETELLRRNVADLEEQNKRITAELNKYKYKS-GGHDSARHHDNAKTEALQEELKAA 708
V E E+L + A EE++ R T+E +K + ++ G + A+ AL EE K
Sbjct: 1762 AKVRAEMEVLLASKARAEEES-RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1820
Query: 709 RLQINELSGKVMQLQYENRVLMSNMQRYDLASHLGIRG--SPRDSDAESDAGKKESDDDS 766
R E + + Q RVL + A+ L + ++ +AE++ ++ ++D++
Sbjct: 1821 RQLAEEDAAR--QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1878
Query: 767 RPPHRKREGPIGGESDSEE 785
R E ++D EE
Sbjct: 1879 FQRRRLEEQAAQHKADIEE 1897
Score = 64.7 bits (156), Expect = 4e-10
Identities = 90/418 (21%), Positives = 178/418 (42%), Gaps = 60/418 (14%)
Query: 344 QQLQEQEEMQEEMEKLRE----ENETLKNEIDELRTEMDEMRDTF------FEEDACQLQ 393
Q Q + +++E + +LR+ E E K +++ + ++ + FE+ A
Sbjct: 1887 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1946
Query: 394 EMRHELERANKNCRILQYRLRKAERKRLRYAQTGEIDGEL-LRSLEQDLKVAKDVSVRLH 452
E+ EL R N + LR E+ L A+ ++ E R E + +V K ++
Sbjct: 1947 ELELELGRIRSNA---EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE-- 2001
Query: 453 HELENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKK 512
E +R +E E+L+ ++ E ++ + E E ++L L + ++ ++E+K
Sbjct: 2002 ---EEAARQRKAALEEVERLKAKVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEK 2056
Query: 513 AQQTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLP 572
A ++ ++L+ LQ +E++ L D+ E + R + +
Sbjct: 2057 AHAFAVQQKEQELQQTLQ--QEQSVL------------DQLRGEAEAARRAAEEAEEARV 2102
Query: 573 KGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDLRGDDFNGSAN 632
+ E S R+ E RL+ EE R + E +AE + R +A
Sbjct: 2103 QAEREAAQSRRQVEEAERLKQSAEE-QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA- 2160
Query: 633 PLMREQSESLSELRQHLQL----------VEDETELLRRNVADLEEQNKRITAELNKYKY 682
+R++ + +E+ +H + VE E LR + + + Q + EL + K
Sbjct: 2161 --LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2218
Query: 683 KSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVMQLQYENRVLM----SNMQRY 736
++ ++AR ++EEL + R+Q+ ELS +++ ENR L+ N QR+
Sbjct: 2219 EAT--EAARQRSQ-----VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2269
Score = 62.4 bits (150), Expect = 2e-09
Identities = 93/427 (21%), Positives = 177/427 (41%), Gaps = 82/427 (19%)
Query: 344 QQLQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERAN 403
Q +QE ++ E E L+++ E + + L+ + ++M A QL E +R
Sbjct: 2321 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM--------AQQLAEETQGFQRTL 2372
Query: 404 KNCRILQYRLR-KAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHE-------- 454
+ R Q + +AER +LR A+ ++ K A+++ +LH
Sbjct: 2373 EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2432
Query: 455 --LENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKK 512
++ +E +R ++ + E+LR+ + E+E K+ LQ E K L LK + + + E+
Sbjct: 2433 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE---AKLLQLKSEEMQTV-QQEQL 2488
Query: 513 AQQTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLP 572
Q+T Q F+ E+ +L++++ I++EK + E Q
Sbjct: 2489 LQETQA--------LQQSFLSEKDSLLQRERF-IEQEKAKLEQLFQD------------- 2526
Query: 573 KGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDLRGDDFNGSAN 632
E+ +L EE+ R+ ++E E + L A +++ R A
Sbjct: 2527 -------------EVAKAQQLREEQQ----RQQQQMEQERQRLVASMEEARRRQH--EAE 2567
Query: 633 PLMREQSESLSEL----RQHLQLVEDETELLRRNVADLEEQNKRITA--------ELNKY 680
+R + E L +L RQ +L+ +E + LR + LEEQ++ A ++
Sbjct: 2568 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2627
Query: 681 KYKSGGHD-----SARHHDNAKTEALQEELKAARLQ-INELSGKVMQLQYENRVLMSNMQ 734
K G D +A + L+ ++ A RLQ LS + +Q + + +
Sbjct: 2628 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELA 2687
Query: 735 RYDLASH 741
R + H
Sbjct: 2688 RREDVRH 2694
Score = 58.5 bits (140), Expect = 3e-08
Identities = 113/541 (20%), Positives = 215/541 (39%), Gaps = 87/541 (16%)
Query: 268 RAAAAAAAAQMHAKNGGGSSSRS-SPVSGPPAVCETLAVASASPMAAAA----EGPQQSA 322
RAA A A++ A+ S R E A A A AAA E Q++A
Sbjct: 2092 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2151
Query: 323 ---EGSASGGGMQAAAPPSSQPHP----QQLQEQEEMQEEMEKLR---EENETLKNEIDE 372
+ + + AA + H Q L+++ ++++E+ LR EE + KN +DE
Sbjct: 2152 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2211
Query: 373 L-------RTEMDEMRDTFFEE------DACQLQEMRHELERANKNC---------RILQ 410
TE R EE +L +++ +E N+ R LQ
Sbjct: 2212 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2271
Query: 411 Y---RLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTTED 467
++++ + R + + L + E+DL + ++ ++ E ++ T +
Sbjct: 2272 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2331
Query: 468 ENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTEEDNEDLKC 527
E E L+QQ + + LQ + E+M ++ L + + Q+T E L+
Sbjct: 2332 EAELLQQQKELAQEQARRLQEDKEQM---------AQQLAEETQGFQRTLEAERQRQLE- 2381
Query: 528 QLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGE-AGGPPSTREAE 586
+ EA ++ ++A++ + + R E + Q++R ++ L + E A T
Sbjct: 2382 ----MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2437
Query: 587 LKLRLRLVEEEANILGRKIVELEVENRGL--KAELDDLRGDDFNGSANPLMREQSESLSE 644
L+++ + + +A L I ELE E L +A+L L+ ++ + +++++L +
Sbjct: 2438 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2497
Query: 645 --------LRQHLQLVEDETELL------------------RRNVADLEEQNKRITAELN 678
L Q + +E E L +R +E++ +R+ A +
Sbjct: 2498 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2557
Query: 679 KYKYKSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVMQLQYENRVLMSNMQRYDL 738
+ + + A K E LQ +L+ R Q EL + Q E L+ R L
Sbjct: 2558 EARRR---QHEAEEGVRRKQEELQ-QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2613
Query: 739 A 739
A
Sbjct: 2614 A 2614
Score = 47.0 bits (110), Expect = 8e-05
Identities = 86/434 (19%), Positives = 188/434 (43%), Gaps = 56/434 (12%)
Query: 358 KLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERANKNCRILQYRLRKAE 417
K++ +E++ E +LRT E+ + ++ + L R + R+ + + R E
Sbjct: 1308 KVQSGSESVIQEYVDLRTHYSELTTLTSQ----YIKFISETLRRMEEEERLAEQQ-RAEE 1362
Query: 418 RKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTTEDENEKLRQQLI 477
R+RL E+ +LE+ ++A+ + +E + ++E + + +
Sbjct: 1363 RERL---------AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1413
Query: 478 EVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTEEDNEDLKCQLQFVKEEAA 537
+ + K+++Q EL+++++ S + + KA+Q E + +L+ ++EE
Sbjct: 1414 DAQQQKRSIQEELQQLRQSS--------EAEIQAKARQAEAAE-----RSRLR-IEEEIR 1459
Query: 538 LMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGEAGGPPSTREAELKLRLRLVEEE 597
++R ++ ++++ E ELQ R + + EA + EAE +LR R V++E
Sbjct: 1460 VVRLQLEATERQRGGAEGELQALR-------ARAEEAEAQKRQAQEEAE-RLR-RQVQDE 1510
Query: 598 ANILGRKIVELEVENRGLKAELDDLRGDDFNGSANPLMREQSESLSELRQHLQLVEDETE 657
+ ++ E+E+ +R +KAE + R A +R Q+E +L + E E
Sbjct: 1511 SQ--RKRQAEVELASR-VKAEAEAAREKQRALQALEELRLQAEEAER-----RLRQAEVE 1562
Query: 658 LLRRNVADLEEQNKRITAELNKYKYKSGGHDSARHHDNAKTEALQEELKAARLQINELSG 717
R+ LE + AEL + ++ A+ E +E A Q+ E +
Sbjct: 1563 RARQVQVALETAQRSAEAELQSKR-------ASFAEKTAQLERSLQEEHVAVAQLREEAE 1615
Query: 718 KVMQLQYE----NRVLMSNMQRYDLASHLGIRGSPRDSDAESDAGKKESDDDSRPPHRKR 773
+ Q Q E ++R+ L ++ +R + + +++ + + +R
Sbjct: 1616 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1675
Query: 774 EGPIGGESDSEEVR 787
E G+++ + VR
Sbjct: 1676 EARRRGKAEEQAVR 1689
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 74.7 bits (182), Expect = 4e-13
Identities = 91/378 (24%), Positives = 162/378 (42%), Gaps = 28/378 (7%)
Query: 344 QQLQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERAN 403
QQ E E +EE E+ E + NE LR + +E+ ++ + E + E A
Sbjct: 1615 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA----QQKSLAQAEAEKQKEEAE 1670
Query: 404 KNCRILQYRLRKAERKRLRYAQTGEIDGELLRSLE----QDLKVAKDVSVRLHHELENVE 459
+ R R KAE + +R + E + E R L Q A+ +RL E E E
Sbjct: 1671 REAR----RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1726
Query: 460 EKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTE 519
++R E+E +L+++ +Q L+ EL K++ SK + E ++ ++
Sbjct: 1727 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1786
Query: 520 EDNEDLKCQLQFVKEEAALMR---------KKMAKIDKEKDRFEHELQKYRSFYGDLDSP 570
+ E + + + EEAA +R +++A+ D + R E E ++
Sbjct: 1787 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1846
Query: 571 LPKGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDLRGDDFNGS 630
K EA +EAE + RL E+EA R++ E ++ KA++++ S
Sbjct: 1847 RLKTEAEIALKEKEAENERLRRLAEDEA-FQRRRLEEQAAQH---KADIEERLAQLRKAS 1902
Query: 631 ANPLMREQSESLSELRQHLQLVEDETELLRRNVADLEEQNKRITAELNKYKYKSGGHDSA 690
+ L R++ LRQ Q+ E E+L + + + EL + +S D+
Sbjct: 1903 DSELERQKGLVEDTLRQRRQV---EEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1959
Query: 691 RHHDNAKTEALQEELKAA 708
R + A+ EA ++ AA
Sbjct: 1960 RSKEQAELEAARQRQLAA 1977
Score = 65.1 bits (157), Expect = 3e-10
Identities = 117/559 (20%), Positives = 225/559 (40%), Gaps = 118/559 (21%)
Query: 313 AAAEGPQQSAEGSASGGGMQAAAPPSSQPHPQQLQEQEEMQEEME-KLREENETLKNEID 371
AA E +Q AE A +A A ++ Q++QE+ +EE +++ +++ E+
Sbjct: 1367 AALEKQRQLAEAHAQA---KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ 1423
Query: 372 ELRTEMD-EMRDTFFEEDACQLQEMRHELERANKNCRILQYRLRKAERKRLRYAQTGEID 430
+LR + E++ + +A + +R E E R+++ +L ER+R G +
Sbjct: 1424 QLRQSSEAEIQAKARQAEAAERSRLRIEEE-----IRVVRLQLEATERQR------GGAE 1472
Query: 431 GELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTTEDENEKLRQQL---------IEVEI 481
GEL L E E ++ ++E E+LR+Q+ EVE+
Sbjct: 1473 GELQA---------------LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1517
Query: 482 AK----------------QAL---------------QNELEKMKELSLKRRGSKDLPKSE 510
A QAL Q E+E+ +++ + ++ ++E
Sbjct: 1518 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1577
Query: 511 KKAQQTPTEEDNEDLKCQLQ-------FVKEEAALMRKKMAKIDKEKDRFEHELQKY--- 560
++++ E L+ LQ ++EEA ++ A+ ++ ++ E EL+++
Sbjct: 1578 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1637
Query: 561 -------RSFYGDLDSPLPKGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENR 613
R ++ +A EAE + R R EE + R++ E E+E +
Sbjct: 1638 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1697
Query: 614 ------------GLKAELDDLRGDDFNGSANPLMREQ------------SESLSELRQHL 649
+ EL LR + G + E+ ++ EL L
Sbjct: 1698 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1757
Query: 650 QLVEDETELLRRNVADLEEQNKRITAELNKYKYKS-GGHDSARHHDNAKTEALQEELKAA 708
V E E+L + A EE++ R T+E +K + ++ G + A+ AL EE K
Sbjct: 1758 AKVRAEMEVLLASKARAEEES-RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1816
Query: 709 RLQINELSGKVMQLQYENRVLMSNMQRYDLASHLGIRG--SPRDSDAESDAGKKESDDDS 766
R E + + Q RVL + A+ L + ++ +AE++ ++ ++D++
Sbjct: 1817 RQLAEEDAAR--QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1874
Query: 767 RPPHRKREGPIGGESDSEE 785
R E ++D EE
Sbjct: 1875 FQRRRLEEQAAQHKADIEE 1893
Score = 64.7 bits (156), Expect = 4e-10
Identities = 90/418 (21%), Positives = 178/418 (42%), Gaps = 60/418 (14%)
Query: 344 QQLQEQEEMQEEMEKLRE----ENETLKNEIDELRTEMDEMRDTF------FEEDACQLQ 393
Q Q + +++E + +LR+ E E K +++ + ++ + FE+ A
Sbjct: 1883 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1942
Query: 394 EMRHELERANKNCRILQYRLRKAERKRLRYAQTGEIDGEL-LRSLEQDLKVAKDVSVRLH 452
E+ EL R N + LR E+ L A+ ++ E R E + +V K ++
Sbjct: 1943 ELELELGRIRSNA---EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE-- 1997
Query: 453 HELENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKK 512
E +R +E E+L+ ++ E ++ + E E ++L L + ++ ++E+K
Sbjct: 1998 ---EEAARQRKAALEEVERLKAKVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEK 2052
Query: 513 AQQTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLP 572
A ++ ++L+ LQ +E++ L D+ E + R + +
Sbjct: 2053 AHAFAVQQKEQELQQTLQ--QEQSVL------------DQLRGEAEAARRAAEEAEEARV 2098
Query: 573 KGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDLRGDDFNGSAN 632
+ E S R+ E RL+ EE R + E +AE + R +A
Sbjct: 2099 QAEREAAQSRRQVEEAERLKQSAEE-QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA- 2156
Query: 633 PLMREQSESLSELRQHLQL----------VEDETELLRRNVADLEEQNKRITAELNKYKY 682
+R++ + +E+ +H + VE E LR + + + Q + EL + K
Sbjct: 2157 --LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2214
Query: 683 KSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVMQLQYENRVLM----SNMQRY 736
++ ++AR ++EEL + R+Q+ ELS +++ ENR L+ N QR+
Sbjct: 2215 EAT--EAARQRSQ-----VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2265
Score = 62.4 bits (150), Expect = 2e-09
Identities = 93/427 (21%), Positives = 177/427 (41%), Gaps = 82/427 (19%)
Query: 344 QQLQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERAN 403
Q +QE ++ E E L+++ E + + L+ + ++M A QL E +R
Sbjct: 2317 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM--------AQQLAEETQGFQRTL 2368
Query: 404 KNCRILQYRLR-KAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHE-------- 454
+ R Q + +AER +LR A+ ++ K A+++ +LH
Sbjct: 2369 EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2428
Query: 455 --LENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKK 512
++ +E +R ++ + E+LR+ + E+E K+ LQ E K L LK + + + E+
Sbjct: 2429 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE---AKLLQLKSEEMQTV-QQEQL 2484
Query: 513 AQQTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLP 572
Q+T Q F+ E+ +L++++ I++EK + E Q
Sbjct: 2485 LQETQA--------LQQSFLSEKDSLLQRERF-IEQEKAKLEQLFQD------------- 2522
Query: 573 KGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDLRGDDFNGSAN 632
E+ +L EE+ R+ ++E E + L A +++ R A
Sbjct: 2523 -------------EVAKAQQLREEQQ----RQQQQMEQERQRLVASMEEARRRQH--EAE 2563
Query: 633 PLMREQSESLSEL----RQHLQLVEDETELLRRNVADLEEQNKRITA--------ELNKY 680
+R + E L +L RQ +L+ +E + LR + LEEQ++ A ++
Sbjct: 2564 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2623
Query: 681 KYKSGGHD-----SARHHDNAKTEALQEELKAARLQ-INELSGKVMQLQYENRVLMSNMQ 734
K G D +A + L+ ++ A RLQ LS + +Q + + +
Sbjct: 2624 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELA 2683
Query: 735 RYDLASH 741
R + H
Sbjct: 2684 RREDVRH 2690
Score = 58.5 bits (140), Expect = 3e-08
Identities = 113/541 (20%), Positives = 215/541 (39%), Gaps = 87/541 (16%)
Query: 268 RAAAAAAAAQMHAKNGGGSSSRS-SPVSGPPAVCETLAVASASPMAAAA----EGPQQSA 322
RAA A A++ A+ S R E A A A AAA E Q++A
Sbjct: 2088 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2147
Query: 323 ---EGSASGGGMQAAAPPSSQPHP----QQLQEQEEMQEEMEKLR---EENETLKNEIDE 372
+ + + AA + H Q L+++ ++++E+ LR EE + KN +DE
Sbjct: 2148 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2207
Query: 373 L-------RTEMDEMRDTFFEE------DACQLQEMRHELERANKNC---------RILQ 410
TE R EE +L +++ +E N+ R LQ
Sbjct: 2208 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2267
Query: 411 Y---RLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTTED 467
++++ + R + + L + E+DL + ++ ++ E ++ T +
Sbjct: 2268 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2327
Query: 468 ENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTEEDNEDLKC 527
E E L+QQ + + LQ + E+M ++ L + + Q+T E L+
Sbjct: 2328 EAELLQQQKELAQEQARRLQEDKEQM---------AQQLAEETQGFQRTLEAERQRQLE- 2377
Query: 528 QLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGE-AGGPPSTREAE 586
+ EA ++ ++A++ + + R E + Q++R ++ L + E A T
Sbjct: 2378 ----MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2433
Query: 587 LKLRLRLVEEEANILGRKIVELEVENRGL--KAELDDLRGDDFNGSANPLMREQSESLSE 644
L+++ + + +A L I ELE E L +A+L L+ ++ + +++++L +
Sbjct: 2434 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2493
Query: 645 --------LRQHLQLVEDETELL------------------RRNVADLEEQNKRITAELN 678
L Q + +E E L +R +E++ +R+ A +
Sbjct: 2494 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2553
Query: 679 KYKYKSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVMQLQYENRVLMSNMQRYDL 738
+ + + A K E LQ +L+ R Q EL + Q E L+ R L
Sbjct: 2554 EARRR---QHEAEEGVRRKQEELQ-QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2609
Query: 739 A 739
A
Sbjct: 2610 A 2610
Score = 47.0 bits (110), Expect = 8e-05
Identities = 86/434 (19%), Positives = 188/434 (43%), Gaps = 56/434 (12%)
Query: 358 KLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERANKNCRILQYRLRKAE 417
K++ +E++ E +LRT E+ + ++ + L R + R+ + + R E
Sbjct: 1304 KVQSGSESVIQEYVDLRTHYSELTTLTSQ----YIKFISETLRRMEEEERLAEQQ-RAEE 1358
Query: 418 RKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTTEDENEKLRQQLI 477
R+RL E+ +LE+ ++A+ + +E + ++E + + +
Sbjct: 1359 RERL---------AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1409
Query: 478 EVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTEEDNEDLKCQLQFVKEEAA 537
+ + K+++Q EL+++++ S + + KA+Q E + +L+ ++EE
Sbjct: 1410 DAQQQKRSIQEELQQLRQSS--------EAEIQAKARQAEAAE-----RSRLR-IEEEIR 1455
Query: 538 LMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGEAGGPPSTREAELKLRLRLVEEE 597
++R ++ ++++ E ELQ R + + EA + EAE +LR R V++E
Sbjct: 1456 VVRLQLEATERQRGGAEGELQALR-------ARAEEAEAQKRQAQEEAE-RLR-RQVQDE 1506
Query: 598 ANILGRKIVELEVENRGLKAELDDLRGDDFNGSANPLMREQSESLSELRQHLQLVEDETE 657
+ ++ E+E+ +R +KAE + R A +R Q+E +L + E E
Sbjct: 1507 SQ--RKRQAEVELASR-VKAEAEAAREKQRALQALEELRLQAEEAER-----RLRQAEVE 1558
Query: 658 LLRRNVADLEEQNKRITAELNKYKYKSGGHDSARHHDNAKTEALQEELKAARLQINELSG 717
R+ LE + AEL + ++ A+ E +E A Q+ E +
Sbjct: 1559 RARQVQVALETAQRSAEAELQSKR-------ASFAEKTAQLERSLQEEHVAVAQLREEAE 1611
Query: 718 KVMQLQYE----NRVLMSNMQRYDLASHLGIRGSPRDSDAESDAGKKESDDDSRPPHRKR 773
+ Q Q E ++R+ L ++ +R + + +++ + + +R
Sbjct: 1612 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1671
Query: 774 EGPIGGESDSEEVR 787
E G+++ + VR
Sbjct: 1672 EARRRGKAEEQAVR 1685
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 74.7 bits (182), Expect = 4e-13
Identities = 91/378 (24%), Positives = 162/378 (42%), Gaps = 28/378 (7%)
Query: 344 QQLQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERAN 403
QQ E E +EE E+ E + NE LR + +E+ ++ + E + E A
Sbjct: 1583 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA----QQKSLAQAEAEKQKEEAE 1638
Query: 404 KNCRILQYRLRKAERKRLRYAQTGEIDGELLRSLE----QDLKVAKDVSVRLHHELENVE 459
+ R R KAE + +R + E + E R L Q A+ +RL E E E
Sbjct: 1639 REAR----RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1694
Query: 460 EKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTE 519
++R E+E +L+++ +Q L+ EL K++ SK + E ++ ++
Sbjct: 1695 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1754
Query: 520 EDNEDLKCQLQFVKEEAALMR---------KKMAKIDKEKDRFEHELQKYRSFYGDLDSP 570
+ E + + + EEAA +R +++A+ D + R E E ++
Sbjct: 1755 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1814
Query: 571 LPKGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDLRGDDFNGS 630
K EA +EAE + RL E+EA R++ E ++ KA++++ S
Sbjct: 1815 RLKTEAEIALKEKEAENERLRRLAEDEA-FQRRRLEEQAAQH---KADIEERLAQLRKAS 1870
Query: 631 ANPLMREQSESLSELRQHLQLVEDETELLRRNVADLEEQNKRITAELNKYKYKSGGHDSA 690
+ L R++ LRQ Q+ E E+L + + + EL + +S D+
Sbjct: 1871 DSELERQKGLVEDTLRQRRQV---EEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1927
Query: 691 RHHDNAKTEALQEELKAA 708
R + A+ EA ++ AA
Sbjct: 1928 RSKEQAELEAARQRQLAA 1945
Score = 65.1 bits (157), Expect = 3e-10
Identities = 117/559 (20%), Positives = 225/559 (40%), Gaps = 118/559 (21%)
Query: 313 AAAEGPQQSAEGSASGGGMQAAAPPSSQPHPQQLQEQEEMQEEME-KLREENETLKNEID 371
AA E +Q AE A +A A ++ Q++QE+ +EE +++ +++ E+
Sbjct: 1335 AALEKQRQLAEAHAQA---KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ 1391
Query: 372 ELRTEMD-EMRDTFFEEDACQLQEMRHELERANKNCRILQYRLRKAERKRLRYAQTGEID 430
+LR + E++ + +A + +R E E R+++ +L ER+R G +
Sbjct: 1392 QLRQSSEAEIQAKARQAEAAERSRLRIEEE-----IRVVRLQLEATERQR------GGAE 1440
Query: 431 GELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTTEDENEKLRQQL---------IEVEI 481
GEL L E E ++ ++E E+LR+Q+ EVE+
Sbjct: 1441 GELQA---------------LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1485
Query: 482 AK----------------QAL---------------QNELEKMKELSLKRRGSKDLPKSE 510
A QAL Q E+E+ +++ + ++ ++E
Sbjct: 1486 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1545
Query: 511 KKAQQTPTEEDNEDLKCQLQ-------FVKEEAALMRKKMAKIDKEKDRFEHELQKY--- 560
++++ E L+ LQ ++EEA ++ A+ ++ ++ E EL+++
Sbjct: 1546 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1605
Query: 561 -------RSFYGDLDSPLPKGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENR 613
R ++ +A EAE + R R EE + R++ E E+E +
Sbjct: 1606 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1665
Query: 614 ------------GLKAELDDLRGDDFNGSANPLMREQ------------SESLSELRQHL 649
+ EL LR + G + E+ ++ EL L
Sbjct: 1666 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1725
Query: 650 QLVEDETELLRRNVADLEEQNKRITAELNKYKYKS-GGHDSARHHDNAKTEALQEELKAA 708
V E E+L + A EE++ R T+E +K + ++ G + A+ AL EE K
Sbjct: 1726 AKVRAEMEVLLASKARAEEES-RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1784
Query: 709 RLQINELSGKVMQLQYENRVLMSNMQRYDLASHLGIRG--SPRDSDAESDAGKKESDDDS 766
R E + + Q RVL + A+ L + ++ +AE++ ++ ++D++
Sbjct: 1785 RQLAEEDAAR--QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1842
Query: 767 RPPHRKREGPIGGESDSEE 785
R E ++D EE
Sbjct: 1843 FQRRRLEEQAAQHKADIEE 1861
Score = 64.7 bits (156), Expect = 4e-10
Identities = 90/418 (21%), Positives = 178/418 (42%), Gaps = 60/418 (14%)
Query: 344 QQLQEQEEMQEEMEKLRE----ENETLKNEIDELRTEMDEMRDTF------FEEDACQLQ 393
Q Q + +++E + +LR+ E E K +++ + ++ + FE+ A
Sbjct: 1851 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1910
Query: 394 EMRHELERANKNCRILQYRLRKAERKRLRYAQTGEIDGEL-LRSLEQDLKVAKDVSVRLH 452
E+ EL R N + LR E+ L A+ ++ E R E + +V K ++
Sbjct: 1911 ELELELGRIRSNA---EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE-- 1965
Query: 453 HELENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKK 512
E +R +E E+L+ ++ E ++ + E E ++L L + ++ ++E+K
Sbjct: 1966 ---EEAARQRKAALEEVERLKAKVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEK 2020
Query: 513 AQQTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLP 572
A ++ ++L+ LQ +E++ L D+ E + R + +
Sbjct: 2021 AHAFAVQQKEQELQQTLQ--QEQSVL------------DQLRGEAEAARRAAEEAEEARV 2066
Query: 573 KGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDLRGDDFNGSAN 632
+ E S R+ E RL+ EE R + E +AE + R +A
Sbjct: 2067 QAEREAAQSRRQVEEAERLKQSAEE-QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA- 2124
Query: 633 PLMREQSESLSELRQHLQL----------VEDETELLRRNVADLEEQNKRITAELNKYKY 682
+R++ + +E+ +H + VE E LR + + + Q + EL + K
Sbjct: 2125 --LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2182
Query: 683 KSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVMQLQYENRVLM----SNMQRY 736
++ ++AR ++EEL + R+Q+ ELS +++ ENR L+ N QR+
Sbjct: 2183 EAT--EAARQRSQ-----VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2233
Score = 62.4 bits (150), Expect = 2e-09
Identities = 93/427 (21%), Positives = 177/427 (41%), Gaps = 82/427 (19%)
Query: 344 QQLQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERAN 403
Q +QE ++ E E L+++ E + + L+ + ++M A QL E +R
Sbjct: 2285 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM--------AQQLAEETQGFQRTL 2336
Query: 404 KNCRILQYRLR-KAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHE-------- 454
+ R Q + +AER +LR A+ ++ K A+++ +LH
Sbjct: 2337 EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2396
Query: 455 --LENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKK 512
++ +E +R ++ + E+LR+ + E+E K+ LQ E K L LK + + + E+
Sbjct: 2397 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE---AKLLQLKSEEMQTV-QQEQL 2452
Query: 513 AQQTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLP 572
Q+T Q F+ E+ +L++++ I++EK + E Q
Sbjct: 2453 LQETQA--------LQQSFLSEKDSLLQRERF-IEQEKAKLEQLFQD------------- 2490
Query: 573 KGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDLRGDDFNGSAN 632
E+ +L EE+ R+ ++E E + L A +++ R A
Sbjct: 2491 -------------EVAKAQQLREEQQ----RQQQQMEQERQRLVASMEEARRRQH--EAE 2531
Query: 633 PLMREQSESLSEL----RQHLQLVEDETELLRRNVADLEEQNKRITA--------ELNKY 680
+R + E L +L RQ +L+ +E + LR + LEEQ++ A ++
Sbjct: 2532 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2591
Query: 681 KYKSGGHD-----SARHHDNAKTEALQEELKAARLQ-INELSGKVMQLQYENRVLMSNMQ 734
K G D +A + L+ ++ A RLQ LS + +Q + + +
Sbjct: 2592 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELA 2651
Query: 735 RYDLASH 741
R + H
Sbjct: 2652 RREDVRH 2658
Score = 58.5 bits (140), Expect = 3e-08
Identities = 113/541 (20%), Positives = 215/541 (39%), Gaps = 87/541 (16%)
Query: 268 RAAAAAAAAQMHAKNGGGSSSRS-SPVSGPPAVCETLAVASASPMAAAA----EGPQQSA 322
RAA A A++ A+ S R E A A A AAA E Q++A
Sbjct: 2056 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2115
Query: 323 ---EGSASGGGMQAAAPPSSQPHP----QQLQEQEEMQEEMEKLR---EENETLKNEIDE 372
+ + + AA + H Q L+++ ++++E+ LR EE + KN +DE
Sbjct: 2116 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2175
Query: 373 L-------RTEMDEMRDTFFEE------DACQLQEMRHELERANKNC---------RILQ 410
TE R EE +L +++ +E N+ R LQ
Sbjct: 2176 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2235
Query: 411 Y---RLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTTED 467
++++ + R + + L + E+DL + ++ ++ E ++ T +
Sbjct: 2236 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2295
Query: 468 ENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTEEDNEDLKC 527
E E L+QQ + + LQ + E+M ++ L + + Q+T E L+
Sbjct: 2296 EAELLQQQKELAQEQARRLQEDKEQM---------AQQLAEETQGFQRTLEAERQRQLE- 2345
Query: 528 QLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGE-AGGPPSTREAE 586
+ EA ++ ++A++ + + R E + Q++R ++ L + E A T
Sbjct: 2346 ----MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2401
Query: 587 LKLRLRLVEEEANILGRKIVELEVENRGL--KAELDDLRGDDFNGSANPLMREQSESLSE 644
L+++ + + +A L I ELE E L +A+L L+ ++ + +++++L +
Sbjct: 2402 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2461
Query: 645 --------LRQHLQLVEDETELL------------------RRNVADLEEQNKRITAELN 678
L Q + +E E L +R +E++ +R+ A +
Sbjct: 2462 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2521
Query: 679 KYKYKSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVMQLQYENRVLMSNMQRYDL 738
+ + + A K E LQ +L+ R Q EL + Q E L+ R L
Sbjct: 2522 EARRR---QHEAEEGVRRKQEELQ-QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2577
Query: 739 A 739
A
Sbjct: 2578 A 2578
Score = 47.0 bits (110), Expect = 8e-05
Identities = 86/434 (19%), Positives = 188/434 (43%), Gaps = 56/434 (12%)
Query: 358 KLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERANKNCRILQYRLRKAE 417
K++ +E++ E +LRT E+ + ++ + L R + R+ + + R E
Sbjct: 1272 KVQSGSESVIQEYVDLRTHYSELTTLTSQ----YIKFISETLRRMEEEERLAEQQ-RAEE 1326
Query: 418 RKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTTEDENEKLRQQLI 477
R+RL E+ +LE+ ++A+ + +E + ++E + + +
Sbjct: 1327 RERL---------AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1377
Query: 478 EVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTEEDNEDLKCQLQFVKEEAA 537
+ + K+++Q EL+++++ S + + KA+Q E + +L+ ++EE
Sbjct: 1378 DAQQQKRSIQEELQQLRQSS--------EAEIQAKARQAEAAE-----RSRLR-IEEEIR 1423
Query: 538 LMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGEAGGPPSTREAELKLRLRLVEEE 597
++R ++ ++++ E ELQ R + + EA + EAE +LR R V++E
Sbjct: 1424 VVRLQLEATERQRGGAEGELQALR-------ARAEEAEAQKRQAQEEAE-RLR-RQVQDE 1474
Query: 598 ANILGRKIVELEVENRGLKAELDDLRGDDFNGSANPLMREQSESLSELRQHLQLVEDETE 657
+ ++ E+E+ +R +KAE + R A +R Q+E +L + E E
Sbjct: 1475 SQ--RKRQAEVELASR-VKAEAEAAREKQRALQALEELRLQAEEAER-----RLRQAEVE 1526
Query: 658 LLRRNVADLEEQNKRITAELNKYKYKSGGHDSARHHDNAKTEALQEELKAARLQINELSG 717
R+ LE + AEL + ++ A+ E +E A Q+ E +
Sbjct: 1527 RARQVQVALETAQRSAEAELQSKR-------ASFAEKTAQLERSLQEEHVAVAQLREEAE 1579
Query: 718 KVMQLQYE----NRVLMSNMQRYDLASHLGIRGSPRDSDAESDAGKKESDDDSRPPHRKR 773
+ Q Q E ++R+ L ++ +R + + +++ + + +R
Sbjct: 1580 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1639
Query: 774 EGPIGGESDSEEVR 787
E G+++ + VR
Sbjct: 1640 EARRRGKAEEQAVR 1653
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 74.7 bits (182), Expect = 4e-13
Identities = 91/378 (24%), Positives = 162/378 (42%), Gaps = 28/378 (7%)
Query: 344 QQLQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERAN 403
QQ E E +EE E+ E + NE LR + +E+ ++ + E + E A
Sbjct: 1752 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA----QQKSLAQAEAEKQKEEAE 1807
Query: 404 KNCRILQYRLRKAERKRLRYAQTGEIDGELLRSLE----QDLKVAKDVSVRLHHELENVE 459
+ R R KAE + +R + E + E R L Q A+ +RL E E E
Sbjct: 1808 REAR----RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1863
Query: 460 EKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTE 519
++R E+E +L+++ +Q L+ EL K++ SK + E ++ ++
Sbjct: 1864 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1923
Query: 520 EDNEDLKCQLQFVKEEAALMR---------KKMAKIDKEKDRFEHELQKYRSFYGDLDSP 570
+ E + + + EEAA +R +++A+ D + R E E ++
Sbjct: 1924 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1983
Query: 571 LPKGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDLRGDDFNGS 630
K EA +EAE + RL E+EA R++ E ++ KA++++ S
Sbjct: 1984 RLKTEAEIALKEKEAENERLRRLAEDEA-FQRRRLEEQAAQH---KADIEERLAQLRKAS 2039
Query: 631 ANPLMREQSESLSELRQHLQLVEDETELLRRNVADLEEQNKRITAELNKYKYKSGGHDSA 690
+ L R++ LRQ Q+ E E+L + + + EL + +S D+
Sbjct: 2040 DSELERQKGLVEDTLRQRRQV---EEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 2096
Query: 691 RHHDNAKTEALQEELKAA 708
R + A+ EA ++ AA
Sbjct: 2097 RSKEQAELEAARQRQLAA 2114
Score = 65.1 bits (157), Expect = 3e-10
Identities = 117/559 (20%), Positives = 225/559 (40%), Gaps = 118/559 (21%)
Query: 313 AAAEGPQQSAEGSASGGGMQAAAPPSSQPHPQQLQEQEEMQEEME-KLREENETLKNEID 371
AA E +Q AE A +A A ++ Q++QE+ +EE +++ +++ E+
Sbjct: 1504 AALEKQRQLAEAHAQA---KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ 1560
Query: 372 ELRTEMD-EMRDTFFEEDACQLQEMRHELERANKNCRILQYRLRKAERKRLRYAQTGEID 430
+LR + E++ + +A + +R E E R+++ +L ER+R G +
Sbjct: 1561 QLRQSSEAEIQAKARQAEAAERSRLRIEEE-----IRVVRLQLEATERQR------GGAE 1609
Query: 431 GELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTTEDENEKLRQQL---------IEVEI 481
GEL L E E ++ ++E E+LR+Q+ EVE+
Sbjct: 1610 GELQA---------------LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1654
Query: 482 AK----------------QAL---------------QNELEKMKELSLKRRGSKDLPKSE 510
A QAL Q E+E+ +++ + ++ ++E
Sbjct: 1655 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1714
Query: 511 KKAQQTPTEEDNEDLKCQLQ-------FVKEEAALMRKKMAKIDKEKDRFEHELQKY--- 560
++++ E L+ LQ ++EEA ++ A+ ++ ++ E EL+++
Sbjct: 1715 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1774
Query: 561 -------RSFYGDLDSPLPKGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENR 613
R ++ +A EAE + R R EE + R++ E E+E +
Sbjct: 1775 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1834
Query: 614 ------------GLKAELDDLRGDDFNGSANPLMREQ------------SESLSELRQHL 649
+ EL LR + G + E+ ++ EL L
Sbjct: 1835 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1894
Query: 650 QLVEDETELLRRNVADLEEQNKRITAELNKYKYKS-GGHDSARHHDNAKTEALQEELKAA 708
V E E+L + A EE++ R T+E +K + ++ G + A+ AL EE K
Sbjct: 1895 AKVRAEMEVLLASKARAEEES-RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1953
Query: 709 RLQINELSGKVMQLQYENRVLMSNMQRYDLASHLGIRG--SPRDSDAESDAGKKESDDDS 766
R E + + Q RVL + A+ L + ++ +AE++ ++ ++D++
Sbjct: 1954 RQLAEEDAAR--QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 2011
Query: 767 RPPHRKREGPIGGESDSEE 785
R E ++D EE
Sbjct: 2012 FQRRRLEEQAAQHKADIEE 2030
Score = 64.7 bits (156), Expect = 4e-10
Identities = 90/418 (21%), Positives = 178/418 (42%), Gaps = 60/418 (14%)
Query: 344 QQLQEQEEMQEEMEKLRE----ENETLKNEIDELRTEMDEMRDTF------FEEDACQLQ 393
Q Q + +++E + +LR+ E E K +++ + ++ + FE+ A
Sbjct: 2020 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 2079
Query: 394 EMRHELERANKNCRILQYRLRKAERKRLRYAQTGEIDGEL-LRSLEQDLKVAKDVSVRLH 452
E+ EL R N + LR E+ L A+ ++ E R E + +V K ++
Sbjct: 2080 ELELELGRIRSNA---EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE-- 2134
Query: 453 HELENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKK 512
E +R +E E+L+ ++ E ++ + E E ++L L + ++ ++E+K
Sbjct: 2135 ---EEAARQRKAALEEVERLKAKVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEK 2189
Query: 513 AQQTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLP 572
A ++ ++L+ LQ +E++ L D+ E + R + +
Sbjct: 2190 AHAFAVQQKEQELQQTLQ--QEQSVL------------DQLRGEAEAARRAAEEAEEARV 2235
Query: 573 KGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDLRGDDFNGSAN 632
+ E S R+ E RL+ EE R + E +AE + R +A
Sbjct: 2236 QAEREAAQSRRQVEEAERLKQSAEE-QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA- 2293
Query: 633 PLMREQSESLSELRQHLQL----------VEDETELLRRNVADLEEQNKRITAELNKYKY 682
+R++ + +E+ +H + VE E LR + + + Q + EL + K
Sbjct: 2294 --LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2351
Query: 683 KSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVMQLQYENRVLM----SNMQRY 736
++ ++AR ++EEL + R+Q+ ELS +++ ENR L+ N QR+
Sbjct: 2352 EAT--EAARQRSQ-----VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2402
Score = 62.4 bits (150), Expect = 2e-09
Identities = 93/427 (21%), Positives = 177/427 (41%), Gaps = 82/427 (19%)
Query: 344 QQLQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERAN 403
Q +QE ++ E E L+++ E + + L+ + ++M A QL E +R
Sbjct: 2454 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM--------AQQLAEETQGFQRTL 2505
Query: 404 KNCRILQYRLR-KAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHE-------- 454
+ R Q + +AER +LR A+ ++ K A+++ +LH
Sbjct: 2506 EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2565
Query: 455 --LENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKK 512
++ +E +R ++ + E+LR+ + E+E K+ LQ E K L LK + + + E+
Sbjct: 2566 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE---AKLLQLKSEEMQTV-QQEQL 2621
Query: 513 AQQTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLP 572
Q+T Q F+ E+ +L++++ I++EK + E Q
Sbjct: 2622 LQETQA--------LQQSFLSEKDSLLQRERF-IEQEKAKLEQLFQD------------- 2659
Query: 573 KGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDLRGDDFNGSAN 632
E+ +L EE+ R+ ++E E + L A +++ R A
Sbjct: 2660 -------------EVAKAQQLREEQQ----RQQQQMEQERQRLVASMEEARRRQH--EAE 2700
Query: 633 PLMREQSESLSEL----RQHLQLVEDETELLRRNVADLEEQNKRITA--------ELNKY 680
+R + E L +L RQ +L+ +E + LR + LEEQ++ A ++
Sbjct: 2701 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2760
Query: 681 KYKSGGHD-----SARHHDNAKTEALQEELKAARLQ-INELSGKVMQLQYENRVLMSNMQ 734
K G D +A + L+ ++ A RLQ LS + +Q + + +
Sbjct: 2761 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELA 2820
Query: 735 RYDLASH 741
R + H
Sbjct: 2821 RREDVRH 2827
Score = 58.5 bits (140), Expect = 3e-08
Identities = 113/541 (20%), Positives = 215/541 (39%), Gaps = 87/541 (16%)
Query: 268 RAAAAAAAAQMHAKNGGGSSSRS-SPVSGPPAVCETLAVASASPMAAAA----EGPQQSA 322
RAA A A++ A+ S R E A A A AAA E Q++A
Sbjct: 2225 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2284
Query: 323 ---EGSASGGGMQAAAPPSSQPHP----QQLQEQEEMQEEMEKLR---EENETLKNEIDE 372
+ + + AA + H Q L+++ ++++E+ LR EE + KN +DE
Sbjct: 2285 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2344
Query: 373 L-------RTEMDEMRDTFFEE------DACQLQEMRHELERANKNC---------RILQ 410
TE R EE +L +++ +E N+ R LQ
Sbjct: 2345 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2404
Query: 411 Y---RLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTTED 467
++++ + R + + L + E+DL + ++ ++ E ++ T +
Sbjct: 2405 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2464
Query: 468 ENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTEEDNEDLKC 527
E E L+QQ + + LQ + E+M ++ L + + Q+T E L+
Sbjct: 2465 EAELLQQQKELAQEQARRLQEDKEQM---------AQQLAEETQGFQRTLEAERQRQLE- 2514
Query: 528 QLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGE-AGGPPSTREAE 586
+ EA ++ ++A++ + + R E + Q++R ++ L + E A T
Sbjct: 2515 ----MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2570
Query: 587 LKLRLRLVEEEANILGRKIVELEVENRGL--KAELDDLRGDDFNGSANPLMREQSESLSE 644
L+++ + + +A L I ELE E L +A+L L+ ++ + +++++L +
Sbjct: 2571 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2630
Query: 645 --------LRQHLQLVEDETELL------------------RRNVADLEEQNKRITAELN 678
L Q + +E E L +R +E++ +R+ A +
Sbjct: 2631 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2690
Query: 679 KYKYKSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVMQLQYENRVLMSNMQRYDL 738
+ + + A K E LQ +L+ R Q EL + Q E L+ R L
Sbjct: 2691 EARRR---QHEAEEGVRRKQEELQ-QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2746
Query: 739 A 739
A
Sbjct: 2747 A 2747
Score = 47.0 bits (110), Expect = 8e-05
Identities = 86/434 (19%), Positives = 188/434 (43%), Gaps = 56/434 (12%)
Query: 358 KLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERANKNCRILQYRLRKAE 417
K++ +E++ E +LRT E+ + ++ + L R + R+ + + R E
Sbjct: 1441 KVQSGSESVIQEYVDLRTHYSELTTLTSQ----YIKFISETLRRMEEEERLAEQQ-RAEE 1495
Query: 418 RKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTTEDENEKLRQQLI 477
R+RL E+ +LE+ ++A+ + +E + ++E + + +
Sbjct: 1496 RERL---------AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1546
Query: 478 EVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTEEDNEDLKCQLQFVKEEAA 537
+ + K+++Q EL+++++ S + + KA+Q E + +L+ ++EE
Sbjct: 1547 DAQQQKRSIQEELQQLRQSS--------EAEIQAKARQAEAAE-----RSRLR-IEEEIR 1592
Query: 538 LMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGEAGGPPSTREAELKLRLRLVEEE 597
++R ++ ++++ E ELQ R + + EA + EAE +LR R V++E
Sbjct: 1593 VVRLQLEATERQRGGAEGELQALR-------ARAEEAEAQKRQAQEEAE-RLR-RQVQDE 1643
Query: 598 ANILGRKIVELEVENRGLKAELDDLRGDDFNGSANPLMREQSESLSELRQHLQLVEDETE 657
+ ++ E+E+ +R +KAE + R A +R Q+E +L + E E
Sbjct: 1644 SQ--RKRQAEVELASR-VKAEAEAAREKQRALQALEELRLQAEEAER-----RLRQAEVE 1695
Query: 658 LLRRNVADLEEQNKRITAELNKYKYKSGGHDSARHHDNAKTEALQEELKAARLQINELSG 717
R+ LE + AEL + ++ A+ E +E A Q+ E +
Sbjct: 1696 RARQVQVALETAQRSAEAELQSKR-------ASFAEKTAQLERSLQEEHVAVAQLREEAE 1748
Query: 718 KVMQLQYE----NRVLMSNMQRYDLASHLGIRGSPRDSDAESDAGKKESDDDSRPPHRKR 773
+ Q Q E ++R+ L ++ +R + + +++ + + +R
Sbjct: 1749 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1808
Query: 774 EGPIGGESDSEEVR 787
E G+++ + VR
Sbjct: 1809 EARRRGKAEEQAVR 1822
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 74.7 bits (182), Expect = 4e-13
Identities = 91/378 (24%), Positives = 162/378 (42%), Gaps = 28/378 (7%)
Query: 344 QQLQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERAN 403
QQ E E +EE E+ E + NE LR + +E+ ++ + E + E A
Sbjct: 1593 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA----QQKSLAQAEAEKQKEEAE 1648
Query: 404 KNCRILQYRLRKAERKRLRYAQTGEIDGELLRSLE----QDLKVAKDVSVRLHHELENVE 459
+ R R KAE + +R + E + E R L Q A+ +RL E E E
Sbjct: 1649 REAR----RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1704
Query: 460 EKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTE 519
++R E+E +L+++ +Q L+ EL K++ SK + E ++ ++
Sbjct: 1705 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1764
Query: 520 EDNEDLKCQLQFVKEEAALMR---------KKMAKIDKEKDRFEHELQKYRSFYGDLDSP 570
+ E + + + EEAA +R +++A+ D + R E E ++
Sbjct: 1765 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1824
Query: 571 LPKGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDLRGDDFNGS 630
K EA +EAE + RL E+EA R++ E ++ KA++++ S
Sbjct: 1825 RLKTEAEIALKEKEAENERLRRLAEDEA-FQRRRLEEQAAQH---KADIEERLAQLRKAS 1880
Query: 631 ANPLMREQSESLSELRQHLQLVEDETELLRRNVADLEEQNKRITAELNKYKYKSGGHDSA 690
+ L R++ LRQ Q+ E E+L + + + EL + +S D+
Sbjct: 1881 DSELERQKGLVEDTLRQRRQV---EEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1937
Query: 691 RHHDNAKTEALQEELKAA 708
R + A+ EA ++ AA
Sbjct: 1938 RSKEQAELEAARQRQLAA 1955
Score = 65.1 bits (157), Expect = 3e-10
Identities = 117/559 (20%), Positives = 225/559 (40%), Gaps = 118/559 (21%)
Query: 313 AAAEGPQQSAEGSASGGGMQAAAPPSSQPHPQQLQEQEEMQEEME-KLREENETLKNEID 371
AA E +Q AE A +A A ++ Q++QE+ +EE +++ +++ E+
Sbjct: 1345 AALEKQRQLAEAHAQA---KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ 1401
Query: 372 ELRTEMD-EMRDTFFEEDACQLQEMRHELERANKNCRILQYRLRKAERKRLRYAQTGEID 430
+LR + E++ + +A + +R E E R+++ +L ER+R G +
Sbjct: 1402 QLRQSSEAEIQAKARQAEAAERSRLRIEEE-----IRVVRLQLEATERQR------GGAE 1450
Query: 431 GELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTTEDENEKLRQQL---------IEVEI 481
GEL L E E ++ ++E E+LR+Q+ EVE+
Sbjct: 1451 GELQA---------------LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1495
Query: 482 AK----------------QAL---------------QNELEKMKELSLKRRGSKDLPKSE 510
A QAL Q E+E+ +++ + ++ ++E
Sbjct: 1496 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1555
Query: 511 KKAQQTPTEEDNEDLKCQLQ-------FVKEEAALMRKKMAKIDKEKDRFEHELQKY--- 560
++++ E L+ LQ ++EEA ++ A+ ++ ++ E EL+++
Sbjct: 1556 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1615
Query: 561 -------RSFYGDLDSPLPKGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENR 613
R ++ +A EAE + R R EE + R++ E E+E +
Sbjct: 1616 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1675
Query: 614 ------------GLKAELDDLRGDDFNGSANPLMREQ------------SESLSELRQHL 649
+ EL LR + G + E+ ++ EL L
Sbjct: 1676 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1735
Query: 650 QLVEDETELLRRNVADLEEQNKRITAELNKYKYKS-GGHDSARHHDNAKTEALQEELKAA 708
V E E+L + A EE++ R T+E +K + ++ G + A+ AL EE K
Sbjct: 1736 AKVRAEMEVLLASKARAEEES-RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1794
Query: 709 RLQINELSGKVMQLQYENRVLMSNMQRYDLASHLGIRG--SPRDSDAESDAGKKESDDDS 766
R E + + Q RVL + A+ L + ++ +AE++ ++ ++D++
Sbjct: 1795 RQLAEEDAAR--QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1852
Query: 767 RPPHRKREGPIGGESDSEE 785
R E ++D EE
Sbjct: 1853 FQRRRLEEQAAQHKADIEE 1871
Score = 64.7 bits (156), Expect = 4e-10
Identities = 90/418 (21%), Positives = 178/418 (42%), Gaps = 60/418 (14%)
Query: 344 QQLQEQEEMQEEMEKLRE----ENETLKNEIDELRTEMDEMRDTF------FEEDACQLQ 393
Q Q + +++E + +LR+ E E K +++ + ++ + FE+ A
Sbjct: 1861 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1920
Query: 394 EMRHELERANKNCRILQYRLRKAERKRLRYAQTGEIDGEL-LRSLEQDLKVAKDVSVRLH 452
E+ EL R N + LR E+ L A+ ++ E R E + +V K ++
Sbjct: 1921 ELELELGRIRSNA---EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE-- 1975
Query: 453 HELENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKK 512
E +R +E E+L+ ++ E ++ + E E ++L L + ++ ++E+K
Sbjct: 1976 ---EEAARQRKAALEEVERLKAKVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEK 2030
Query: 513 AQQTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLP 572
A ++ ++L+ LQ +E++ L D+ E + R + +
Sbjct: 2031 AHAFAVQQKEQELQQTLQ--QEQSVL------------DQLRGEAEAARRAAEEAEEARV 2076
Query: 573 KGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDLRGDDFNGSAN 632
+ E S R+ E RL+ EE R + E +AE + R +A
Sbjct: 2077 QAEREAAQSRRQVEEAERLKQSAEE-QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA- 2134
Query: 633 PLMREQSESLSELRQHLQL----------VEDETELLRRNVADLEEQNKRITAELNKYKY 682
+R++ + +E+ +H + VE E LR + + + Q + EL + K
Sbjct: 2135 --LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2192
Query: 683 KSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVMQLQYENRVLM----SNMQRY 736
++ ++AR ++EEL + R+Q+ ELS +++ ENR L+ N QR+
Sbjct: 2193 EAT--EAARQRSQ-----VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2243
Score = 62.4 bits (150), Expect = 2e-09
Identities = 93/427 (21%), Positives = 177/427 (41%), Gaps = 82/427 (19%)
Query: 344 QQLQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERAN 403
Q +QE ++ E E L+++ E + + L+ + ++M A QL E +R
Sbjct: 2295 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM--------AQQLAEETQGFQRTL 2346
Query: 404 KNCRILQYRLR-KAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHE-------- 454
+ R Q + +AER +LR A+ ++ K A+++ +LH
Sbjct: 2347 EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2406
Query: 455 --LENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKK 512
++ +E +R ++ + E+LR+ + E+E K+ LQ E K L LK + + + E+
Sbjct: 2407 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE---AKLLQLKSEEMQTV-QQEQL 2462
Query: 513 AQQTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLP 572
Q+T Q F+ E+ +L++++ I++EK + E Q
Sbjct: 2463 LQETQA--------LQQSFLSEKDSLLQRERF-IEQEKAKLEQLFQD------------- 2500
Query: 573 KGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDLRGDDFNGSAN 632
E+ +L EE+ R+ ++E E + L A +++ R A
Sbjct: 2501 -------------EVAKAQQLREEQQ----RQQQQMEQERQRLVASMEEARRRQH--EAE 2541
Query: 633 PLMREQSESLSEL----RQHLQLVEDETELLRRNVADLEEQNKRITA--------ELNKY 680
+R + E L +L RQ +L+ +E + LR + LEEQ++ A ++
Sbjct: 2542 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2601
Query: 681 KYKSGGHD-----SARHHDNAKTEALQEELKAARLQ-INELSGKVMQLQYENRVLMSNMQ 734
K G D +A + L+ ++ A RLQ LS + +Q + + +
Sbjct: 2602 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELA 2661
Query: 735 RYDLASH 741
R + H
Sbjct: 2662 RREDVRH 2668
Score = 58.5 bits (140), Expect = 3e-08
Identities = 113/541 (20%), Positives = 215/541 (39%), Gaps = 87/541 (16%)
Query: 268 RAAAAAAAAQMHAKNGGGSSSRS-SPVSGPPAVCETLAVASASPMAAAA----EGPQQSA 322
RAA A A++ A+ S R E A A A AAA E Q++A
Sbjct: 2066 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2125
Query: 323 ---EGSASGGGMQAAAPPSSQPHP----QQLQEQEEMQEEMEKLR---EENETLKNEIDE 372
+ + + AA + H Q L+++ ++++E+ LR EE + KN +DE
Sbjct: 2126 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2185
Query: 373 L-------RTEMDEMRDTFFEE------DACQLQEMRHELERANKNC---------RILQ 410
TE R EE +L +++ +E N+ R LQ
Sbjct: 2186 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2245
Query: 411 Y---RLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTTED 467
++++ + R + + L + E+DL + ++ ++ E ++ T +
Sbjct: 2246 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2305
Query: 468 ENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTEEDNEDLKC 527
E E L+QQ + + LQ + E+M ++ L + + Q+T E L+
Sbjct: 2306 EAELLQQQKELAQEQARRLQEDKEQM---------AQQLAEETQGFQRTLEAERQRQLE- 2355
Query: 528 QLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGE-AGGPPSTREAE 586
+ EA ++ ++A++ + + R E + Q++R ++ L + E A T
Sbjct: 2356 ----MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2411
Query: 587 LKLRLRLVEEEANILGRKIVELEVENRGL--KAELDDLRGDDFNGSANPLMREQSESLSE 644
L+++ + + +A L I ELE E L +A+L L+ ++ + +++++L +
Sbjct: 2412 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2471
Query: 645 --------LRQHLQLVEDETELL------------------RRNVADLEEQNKRITAELN 678
L Q + +E E L +R +E++ +R+ A +
Sbjct: 2472 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2531
Query: 679 KYKYKSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVMQLQYENRVLMSNMQRYDL 738
+ + + A K E LQ +L+ R Q EL + Q E L+ R L
Sbjct: 2532 EARRR---QHEAEEGVRRKQEELQ-QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2587
Query: 739 A 739
A
Sbjct: 2588 A 2588
Score = 47.0 bits (110), Expect = 8e-05
Identities = 86/434 (19%), Positives = 188/434 (43%), Gaps = 56/434 (12%)
Query: 358 KLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERANKNCRILQYRLRKAE 417
K++ +E++ E +LRT E+ + ++ + L R + R+ + + R E
Sbjct: 1282 KVQSGSESVIQEYVDLRTHYSELTTLTSQ----YIKFISETLRRMEEEERLAEQQ-RAEE 1336
Query: 418 RKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTTEDENEKLRQQLI 477
R+RL E+ +LE+ ++A+ + +E + ++E + + +
Sbjct: 1337 RERL---------AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1387
Query: 478 EVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTEEDNEDLKCQLQFVKEEAA 537
+ + K+++Q EL+++++ S + + KA+Q E + +L+ ++EE
Sbjct: 1388 DAQQQKRSIQEELQQLRQSS--------EAEIQAKARQAEAAE-----RSRLR-IEEEIR 1433
Query: 538 LMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGEAGGPPSTREAELKLRLRLVEEE 597
++R ++ ++++ E ELQ R + + EA + EAE +LR R V++E
Sbjct: 1434 VVRLQLEATERQRGGAEGELQALR-------ARAEEAEAQKRQAQEEAE-RLR-RQVQDE 1484
Query: 598 ANILGRKIVELEVENRGLKAELDDLRGDDFNGSANPLMREQSESLSELRQHLQLVEDETE 657
+ ++ E+E+ +R +KAE + R A +R Q+E +L + E E
Sbjct: 1485 SQ--RKRQAEVELASR-VKAEAEAAREKQRALQALEELRLQAEEAER-----RLRQAEVE 1536
Query: 658 LLRRNVADLEEQNKRITAELNKYKYKSGGHDSARHHDNAKTEALQEELKAARLQINELSG 717
R+ LE + AEL + ++ A+ E +E A Q+ E +
Sbjct: 1537 RARQVQVALETAQRSAEAELQSKR-------ASFAEKTAQLERSLQEEHVAVAQLREEAE 1589
Query: 718 KVMQLQYE----NRVLMSNMQRYDLASHLGIRGSPRDSDAESDAGKKESDDDSRPPHRKR 773
+ Q Q E ++R+ L ++ +R + + +++ + + +R
Sbjct: 1590 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1649
Query: 774 EGPIGGESDSEEVR 787
E G+++ + VR
Sbjct: 1650 EARRRGKAEEQAVR 1663
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 74.7 bits (182), Expect = 4e-13
Identities = 91/378 (24%), Positives = 162/378 (42%), Gaps = 28/378 (7%)
Query: 344 QQLQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERAN 403
QQ E E +EE E+ E + NE LR + +E+ ++ + E + E A
Sbjct: 1601 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA----QQKSLAQAEAEKQKEEAE 1656
Query: 404 KNCRILQYRLRKAERKRLRYAQTGEIDGELLRSLE----QDLKVAKDVSVRLHHELENVE 459
+ R R KAE + +R + E + E R L Q A+ +RL E E E
Sbjct: 1657 REAR----RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1712
Query: 460 EKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTE 519
++R E+E +L+++ +Q L+ EL K++ SK + E ++ ++
Sbjct: 1713 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1772
Query: 520 EDNEDLKCQLQFVKEEAALMR---------KKMAKIDKEKDRFEHELQKYRSFYGDLDSP 570
+ E + + + EEAA +R +++A+ D + R E E ++
Sbjct: 1773 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1832
Query: 571 LPKGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDLRGDDFNGS 630
K EA +EAE + RL E+EA R++ E ++ KA++++ S
Sbjct: 1833 RLKTEAEIALKEKEAENERLRRLAEDEA-FQRRRLEEQAAQH---KADIEERLAQLRKAS 1888
Query: 631 ANPLMREQSESLSELRQHLQLVEDETELLRRNVADLEEQNKRITAELNKYKYKSGGHDSA 690
+ L R++ LRQ Q+ E E+L + + + EL + +S D+
Sbjct: 1889 DSELERQKGLVEDTLRQRRQV---EEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1945
Query: 691 RHHDNAKTEALQEELKAA 708
R + A+ EA ++ AA
Sbjct: 1946 RSKEQAELEAARQRQLAA 1963
Score = 65.1 bits (157), Expect = 3e-10
Identities = 117/559 (20%), Positives = 225/559 (40%), Gaps = 118/559 (21%)
Query: 313 AAAEGPQQSAEGSASGGGMQAAAPPSSQPHPQQLQEQEEMQEEME-KLREENETLKNEID 371
AA E +Q AE A +A A ++ Q++QE+ +EE +++ +++ E+
Sbjct: 1353 AALEKQRQLAEAHAQA---KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ 1409
Query: 372 ELRTEMD-EMRDTFFEEDACQLQEMRHELERANKNCRILQYRLRKAERKRLRYAQTGEID 430
+LR + E++ + +A + +R E E R+++ +L ER+R G +
Sbjct: 1410 QLRQSSEAEIQAKARQAEAAERSRLRIEEE-----IRVVRLQLEATERQR------GGAE 1458
Query: 431 GELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTTEDENEKLRQQL---------IEVEI 481
GEL L E E ++ ++E E+LR+Q+ EVE+
Sbjct: 1459 GELQA---------------LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1503
Query: 482 AK----------------QAL---------------QNELEKMKELSLKRRGSKDLPKSE 510
A QAL Q E+E+ +++ + ++ ++E
Sbjct: 1504 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1563
Query: 511 KKAQQTPTEEDNEDLKCQLQ-------FVKEEAALMRKKMAKIDKEKDRFEHELQKY--- 560
++++ E L+ LQ ++EEA ++ A+ ++ ++ E EL+++
Sbjct: 1564 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1623
Query: 561 -------RSFYGDLDSPLPKGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENR 613
R ++ +A EAE + R R EE + R++ E E+E +
Sbjct: 1624 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1683
Query: 614 ------------GLKAELDDLRGDDFNGSANPLMREQ------------SESLSELRQHL 649
+ EL LR + G + E+ ++ EL L
Sbjct: 1684 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1743
Query: 650 QLVEDETELLRRNVADLEEQNKRITAELNKYKYKS-GGHDSARHHDNAKTEALQEELKAA 708
V E E+L + A EE++ R T+E +K + ++ G + A+ AL EE K
Sbjct: 1744 AKVRAEMEVLLASKARAEEES-RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1802
Query: 709 RLQINELSGKVMQLQYENRVLMSNMQRYDLASHLGIRG--SPRDSDAESDAGKKESDDDS 766
R E + + Q RVL + A+ L + ++ +AE++ ++ ++D++
Sbjct: 1803 RQLAEEDAAR--QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1860
Query: 767 RPPHRKREGPIGGESDSEE 785
R E ++D EE
Sbjct: 1861 FQRRRLEEQAAQHKADIEE 1879
Score = 64.7 bits (156), Expect = 4e-10
Identities = 90/418 (21%), Positives = 178/418 (42%), Gaps = 60/418 (14%)
Query: 344 QQLQEQEEMQEEMEKLRE----ENETLKNEIDELRTEMDEMRDTF------FEEDACQLQ 393
Q Q + +++E + +LR+ E E K +++ + ++ + FE+ A
Sbjct: 1869 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1928
Query: 394 EMRHELERANKNCRILQYRLRKAERKRLRYAQTGEIDGEL-LRSLEQDLKVAKDVSVRLH 452
E+ EL R N + LR E+ L A+ ++ E R E + +V K ++
Sbjct: 1929 ELELELGRIRSNA---EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE-- 1983
Query: 453 HELENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKK 512
E +R +E E+L+ ++ E ++ + E E ++L L + ++ ++E+K
Sbjct: 1984 ---EEAARQRKAALEEVERLKAKVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEK 2038
Query: 513 AQQTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLP 572
A ++ ++L+ LQ +E++ L D+ E + R + +
Sbjct: 2039 AHAFAVQQKEQELQQTLQ--QEQSVL------------DQLRGEAEAARRAAEEAEEARV 2084
Query: 573 KGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDLRGDDFNGSAN 632
+ E S R+ E RL+ EE R + E +AE + R +A
Sbjct: 2085 QAEREAAQSRRQVEEAERLKQSAEE-QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA- 2142
Query: 633 PLMREQSESLSELRQHLQL----------VEDETELLRRNVADLEEQNKRITAELNKYKY 682
+R++ + +E+ +H + VE E LR + + + Q + EL + K
Sbjct: 2143 --LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2200
Query: 683 KSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVMQLQYENRVLM----SNMQRY 736
++ ++AR ++EEL + R+Q+ ELS +++ ENR L+ N QR+
Sbjct: 2201 EAT--EAARQRSQ-----VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2251
Score = 62.4 bits (150), Expect = 2e-09
Identities = 93/427 (21%), Positives = 177/427 (41%), Gaps = 82/427 (19%)
Query: 344 QQLQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERAN 403
Q +QE ++ E E L+++ E + + L+ + ++M A QL E +R
Sbjct: 2303 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM--------AQQLAEETQGFQRTL 2354
Query: 404 KNCRILQYRLR-KAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHE-------- 454
+ R Q + +AER +LR A+ ++ K A+++ +LH
Sbjct: 2355 EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2414
Query: 455 --LENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKK 512
++ +E +R ++ + E+LR+ + E+E K+ LQ E K L LK + + + E+
Sbjct: 2415 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE---AKLLQLKSEEMQTV-QQEQL 2470
Query: 513 AQQTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLP 572
Q+T Q F+ E+ +L++++ I++EK + E Q
Sbjct: 2471 LQETQA--------LQQSFLSEKDSLLQRERF-IEQEKAKLEQLFQD------------- 2508
Query: 573 KGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDLRGDDFNGSAN 632
E+ +L EE+ R+ ++E E + L A +++ R A
Sbjct: 2509 -------------EVAKAQQLREEQQ----RQQQQMEQERQRLVASMEEARRRQH--EAE 2549
Query: 633 PLMREQSESLSEL----RQHLQLVEDETELLRRNVADLEEQNKRITA--------ELNKY 680
+R + E L +L RQ +L+ +E + LR + LEEQ++ A ++
Sbjct: 2550 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2609
Query: 681 KYKSGGHD-----SARHHDNAKTEALQEELKAARLQ-INELSGKVMQLQYENRVLMSNMQ 734
K G D +A + L+ ++ A RLQ LS + +Q + + +
Sbjct: 2610 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELA 2669
Query: 735 RYDLASH 741
R + H
Sbjct: 2670 RREDVRH 2676
Score = 58.5 bits (140), Expect = 3e-08
Identities = 113/541 (20%), Positives = 215/541 (39%), Gaps = 87/541 (16%)
Query: 268 RAAAAAAAAQMHAKNGGGSSSRS-SPVSGPPAVCETLAVASASPMAAAA----EGPQQSA 322
RAA A A++ A+ S R E A A A AAA E Q++A
Sbjct: 2074 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2133
Query: 323 ---EGSASGGGMQAAAPPSSQPHP----QQLQEQEEMQEEMEKLR---EENETLKNEIDE 372
+ + + AA + H Q L+++ ++++E+ LR EE + KN +DE
Sbjct: 2134 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2193
Query: 373 L-------RTEMDEMRDTFFEE------DACQLQEMRHELERANKNC---------RILQ 410
TE R EE +L +++ +E N+ R LQ
Sbjct: 2194 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2253
Query: 411 Y---RLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTTED 467
++++ + R + + L + E+DL + ++ ++ E ++ T +
Sbjct: 2254 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2313
Query: 468 ENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTEEDNEDLKC 527
E E L+QQ + + LQ + E+M ++ L + + Q+T E L+
Sbjct: 2314 EAELLQQQKELAQEQARRLQEDKEQM---------AQQLAEETQGFQRTLEAERQRQLE- 2363
Query: 528 QLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGE-AGGPPSTREAE 586
+ EA ++ ++A++ + + R E + Q++R ++ L + E A T
Sbjct: 2364 ----MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2419
Query: 587 LKLRLRLVEEEANILGRKIVELEVENRGL--KAELDDLRGDDFNGSANPLMREQSESLSE 644
L+++ + + +A L I ELE E L +A+L L+ ++ + +++++L +
Sbjct: 2420 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2479
Query: 645 --------LRQHLQLVEDETELL------------------RRNVADLEEQNKRITAELN 678
L Q + +E E L +R +E++ +R+ A +
Sbjct: 2480 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2539
Query: 679 KYKYKSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVMQLQYENRVLMSNMQRYDL 738
+ + + A K E LQ +L+ R Q EL + Q E L+ R L
Sbjct: 2540 EARRR---QHEAEEGVRRKQEELQ-QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2595
Query: 739 A 739
A
Sbjct: 2596 A 2596
Score = 47.0 bits (110), Expect = 8e-05
Identities = 86/434 (19%), Positives = 188/434 (43%), Gaps = 56/434 (12%)
Query: 358 KLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERANKNCRILQYRLRKAE 417
K++ +E++ E +LRT E+ + ++ + L R + R+ + + R E
Sbjct: 1290 KVQSGSESVIQEYVDLRTHYSELTTLTSQ----YIKFISETLRRMEEEERLAEQQ-RAEE 1344
Query: 418 RKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTTEDENEKLRQQLI 477
R+RL E+ +LE+ ++A+ + +E + ++E + + +
Sbjct: 1345 RERL---------AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1395
Query: 478 EVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTEEDNEDLKCQLQFVKEEAA 537
+ + K+++Q EL+++++ S + + KA+Q E + +L+ ++EE
Sbjct: 1396 DAQQQKRSIQEELQQLRQSS--------EAEIQAKARQAEAAE-----RSRLR-IEEEIR 1441
Query: 538 LMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGEAGGPPSTREAELKLRLRLVEEE 597
++R ++ ++++ E ELQ R + + EA + EAE +LR R V++E
Sbjct: 1442 VVRLQLEATERQRGGAEGELQALR-------ARAEEAEAQKRQAQEEAE-RLR-RQVQDE 1492
Query: 598 ANILGRKIVELEVENRGLKAELDDLRGDDFNGSANPLMREQSESLSELRQHLQLVEDETE 657
+ ++ E+E+ +R +KAE + R A +R Q+E +L + E E
Sbjct: 1493 SQ--RKRQAEVELASR-VKAEAEAAREKQRALQALEELRLQAEEAER-----RLRQAEVE 1544
Query: 658 LLRRNVADLEEQNKRITAELNKYKYKSGGHDSARHHDNAKTEALQEELKAARLQINELSG 717
R+ LE + AEL + ++ A+ E +E A Q+ E +
Sbjct: 1545 RARQVQVALETAQRSAEAELQSKR-------ASFAEKTAQLERSLQEEHVAVAQLREEAE 1597
Query: 718 KVMQLQYE----NRVLMSNMQRYDLASHLGIRGSPRDSDAESDAGKKESDDDSRPPHRKR 773
+ Q Q E ++R+ L ++ +R + + +++ + + +R
Sbjct: 1598 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1657
Query: 774 EGPIGGESDSEEVR 787
E G+++ + VR
Sbjct: 1658 EARRRGKAEEQAVR 1671
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 74.7 bits (182), Expect = 4e-13
Identities = 91/378 (24%), Positives = 162/378 (42%), Gaps = 28/378 (7%)
Query: 344 QQLQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERAN 403
QQ E E +EE E+ E + NE LR + +E+ ++ + E + E A
Sbjct: 1642 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA----QQKSLAQAEAEKQKEEAE 1697
Query: 404 KNCRILQYRLRKAERKRLRYAQTGEIDGELLRSLE----QDLKVAKDVSVRLHHELENVE 459
+ R R KAE + +R + E + E R L Q A+ +RL E E E
Sbjct: 1698 REAR----RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1753
Query: 460 EKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTE 519
++R E+E +L+++ +Q L+ EL K++ SK + E ++ ++
Sbjct: 1754 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1813
Query: 520 EDNEDLKCQLQFVKEEAALMR---------KKMAKIDKEKDRFEHELQKYRSFYGDLDSP 570
+ E + + + EEAA +R +++A+ D + R E E ++
Sbjct: 1814 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1873
Query: 571 LPKGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDLRGDDFNGS 630
K EA +EAE + RL E+EA R++ E ++ KA++++ S
Sbjct: 1874 RLKTEAEIALKEKEAENERLRRLAEDEA-FQRRRLEEQAAQH---KADIEERLAQLRKAS 1929
Query: 631 ANPLMREQSESLSELRQHLQLVEDETELLRRNVADLEEQNKRITAELNKYKYKSGGHDSA 690
+ L R++ LRQ Q+ E E+L + + + EL + +S D+
Sbjct: 1930 DSELERQKGLVEDTLRQRRQV---EEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1986
Query: 691 RHHDNAKTEALQEELKAA 708
R + A+ EA ++ AA
Sbjct: 1987 RSKEQAELEAARQRQLAA 2004
Score = 65.1 bits (157), Expect = 3e-10
Identities = 117/559 (20%), Positives = 225/559 (40%), Gaps = 118/559 (21%)
Query: 313 AAAEGPQQSAEGSASGGGMQAAAPPSSQPHPQQLQEQEEMQEEME-KLREENETLKNEID 371
AA E +Q AE A +A A ++ Q++QE+ +EE +++ +++ E+
Sbjct: 1394 AALEKQRQLAEAHAQA---KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ 1450
Query: 372 ELRTEMD-EMRDTFFEEDACQLQEMRHELERANKNCRILQYRLRKAERKRLRYAQTGEID 430
+LR + E++ + +A + +R E E R+++ +L ER+R G +
Sbjct: 1451 QLRQSSEAEIQAKARQAEAAERSRLRIEEE-----IRVVRLQLEATERQR------GGAE 1499
Query: 431 GELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTTEDENEKLRQQL---------IEVEI 481
GEL L E E ++ ++E E+LR+Q+ EVE+
Sbjct: 1500 GELQA---------------LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1544
Query: 482 AK----------------QAL---------------QNELEKMKELSLKRRGSKDLPKSE 510
A QAL Q E+E+ +++ + ++ ++E
Sbjct: 1545 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1604
Query: 511 KKAQQTPTEEDNEDLKCQLQ-------FVKEEAALMRKKMAKIDKEKDRFEHELQKY--- 560
++++ E L+ LQ ++EEA ++ A+ ++ ++ E EL+++
Sbjct: 1605 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1664
Query: 561 -------RSFYGDLDSPLPKGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENR 613
R ++ +A EAE + R R EE + R++ E E+E +
Sbjct: 1665 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1724
Query: 614 ------------GLKAELDDLRGDDFNGSANPLMREQ------------SESLSELRQHL 649
+ EL LR + G + E+ ++ EL L
Sbjct: 1725 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1784
Query: 650 QLVEDETELLRRNVADLEEQNKRITAELNKYKYKS-GGHDSARHHDNAKTEALQEELKAA 708
V E E+L + A EE++ R T+E +K + ++ G + A+ AL EE K
Sbjct: 1785 AKVRAEMEVLLASKARAEEES-RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1843
Query: 709 RLQINELSGKVMQLQYENRVLMSNMQRYDLASHLGIRG--SPRDSDAESDAGKKESDDDS 766
R E + + Q RVL + A+ L + ++ +AE++ ++ ++D++
Sbjct: 1844 RQLAEEDAAR--QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1901
Query: 767 RPPHRKREGPIGGESDSEE 785
R E ++D EE
Sbjct: 1902 FQRRRLEEQAAQHKADIEE 1920
Score = 64.7 bits (156), Expect = 4e-10
Identities = 90/418 (21%), Positives = 178/418 (42%), Gaps = 60/418 (14%)
Query: 344 QQLQEQEEMQEEMEKLRE----ENETLKNEIDELRTEMDEMRDTF------FEEDACQLQ 393
Q Q + +++E + +LR+ E E K +++ + ++ + FE+ A
Sbjct: 1910 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1969
Query: 394 EMRHELERANKNCRILQYRLRKAERKRLRYAQTGEIDGEL-LRSLEQDLKVAKDVSVRLH 452
E+ EL R N + LR E+ L A+ ++ E R E + +V K ++
Sbjct: 1970 ELELELGRIRSNA---EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE-- 2024
Query: 453 HELENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKK 512
E +R +E E+L+ ++ E ++ + E E ++L L + ++ ++E+K
Sbjct: 2025 ---EEAARQRKAALEEVERLKAKVEEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEK 2079
Query: 513 AQQTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLP 572
A ++ ++L+ LQ +E++ L D+ E + R + +
Sbjct: 2080 AHAFAVQQKEQELQQTLQ--QEQSVL------------DQLRGEAEAARRAAEEAEEARV 2125
Query: 573 KGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDLRGDDFNGSAN 632
+ E S R+ E RL+ EE R + E +AE + R +A
Sbjct: 2126 QAEREAAQSRRQVEEAERLKQSAEE-QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA- 2183
Query: 633 PLMREQSESLSELRQHLQL----------VEDETELLRRNVADLEEQNKRITAELNKYKY 682
+R++ + +E+ +H + VE E LR + + + Q + EL + K
Sbjct: 2184 --LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA 2241
Query: 683 KSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVMQLQYENRVLM----SNMQRY 736
++ ++AR ++EEL + R+Q+ ELS +++ ENR L+ N QR+
Sbjct: 2242 EAT--EAARQRSQ-----VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF 2292
Score = 62.4 bits (150), Expect = 2e-09
Identities = 93/427 (21%), Positives = 177/427 (41%), Gaps = 82/427 (19%)
Query: 344 QQLQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERAN 403
Q +QE ++ E E L+++ E + + L+ + ++M A QL E +R
Sbjct: 2344 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM--------AQQLAEETQGFQRTL 2395
Query: 404 KNCRILQYRLR-KAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHE-------- 454
+ R Q + +AER +LR A+ ++ K A+++ +LH
Sbjct: 2396 EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2455
Query: 455 --LENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKK 512
++ +E +R ++ + E+LR+ + E+E K+ LQ E K L LK + + + E+
Sbjct: 2456 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE---AKLLQLKSEEMQTV-QQEQL 2511
Query: 513 AQQTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLP 572
Q+T Q F+ E+ +L++++ I++EK + E Q
Sbjct: 2512 LQETQA--------LQQSFLSEKDSLLQRERF-IEQEKAKLEQLFQD------------- 2549
Query: 573 KGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDLRGDDFNGSAN 632
E+ +L EE+ R+ ++E E + L A +++ R A
Sbjct: 2550 -------------EVAKAQQLREEQQ----RQQQQMEQERQRLVASMEEARRRQH--EAE 2590
Query: 633 PLMREQSESLSEL----RQHLQLVEDETELLRRNVADLEEQNKRITA--------ELNKY 680
+R + E L +L RQ +L+ +E + LR + LEEQ++ A ++
Sbjct: 2591 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2650
Query: 681 KYKSGGHD-----SARHHDNAKTEALQEELKAARLQ-INELSGKVMQLQYENRVLMSNMQ 734
K G D +A + L+ ++ A RLQ LS + +Q + + +
Sbjct: 2651 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELA 2710
Query: 735 RYDLASH 741
R + H
Sbjct: 2711 RREDVRH 2717
Score = 58.5 bits (140), Expect = 3e-08
Identities = 113/541 (20%), Positives = 215/541 (39%), Gaps = 87/541 (16%)
Query: 268 RAAAAAAAAQMHAKNGGGSSSRS-SPVSGPPAVCETLAVASASPMAAAA----EGPQQSA 322
RAA A A++ A+ S R E A A A AAA E Q++A
Sbjct: 2115 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2174
Query: 323 ---EGSASGGGMQAAAPPSSQPHP----QQLQEQEEMQEEMEKLR---EENETLKNEIDE 372
+ + + AA + H Q L+++ ++++E+ LR EE + KN +DE
Sbjct: 2175 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2234
Query: 373 L-------RTEMDEMRDTFFEE------DACQLQEMRHELERANKNC---------RILQ 410
TE R EE +L +++ +E N+ R LQ
Sbjct: 2235 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2294
Query: 411 Y---RLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTTED 467
++++ + R + + L + E+DL + ++ ++ E ++ T +
Sbjct: 2295 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2354
Query: 468 ENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTEEDNEDLKC 527
E E L+QQ + + LQ + E+M ++ L + + Q+T E L+
Sbjct: 2355 EAELLQQQKELAQEQARRLQEDKEQM---------AQQLAEETQGFQRTLEAERQRQLE- 2404
Query: 528 QLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGE-AGGPPSTREAE 586
+ EA ++ ++A++ + + R E + Q++R ++ L + E A T
Sbjct: 2405 ----MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2460
Query: 587 LKLRLRLVEEEANILGRKIVELEVENRGL--KAELDDLRGDDFNGSANPLMREQSESLSE 644
L+++ + + +A L I ELE E L +A+L L+ ++ + +++++L +
Sbjct: 2461 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2520
Query: 645 --------LRQHLQLVEDETELL------------------RRNVADLEEQNKRITAELN 678
L Q + +E E L +R +E++ +R+ A +
Sbjct: 2521 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2580
Query: 679 KYKYKSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVMQLQYENRVLMSNMQRYDL 738
+ + + A K E LQ +L+ R Q EL + Q E L+ R L
Sbjct: 2581 EARRR---QHEAEEGVRRKQEELQ-QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2636
Query: 739 A 739
A
Sbjct: 2637 A 2637
Score = 47.0 bits (110), Expect = 8e-05
Identities = 86/434 (19%), Positives = 188/434 (43%), Gaps = 56/434 (12%)
Query: 358 KLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERANKNCRILQYRLRKAE 417
K++ +E++ E +LRT E+ + ++ + L R + R+ + + R E
Sbjct: 1331 KVQSGSESVIQEYVDLRTHYSELTTLTSQ----YIKFISETLRRMEEEERLAEQQ-RAEE 1385
Query: 418 RKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTTEDENEKLRQQLI 477
R+RL E+ +LE+ ++A+ + +E + ++E + + +
Sbjct: 1386 RERL---------AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1436
Query: 478 EVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTEEDNEDLKCQLQFVKEEAA 537
+ + K+++Q EL+++++ S + + KA+Q E + +L+ ++EE
Sbjct: 1437 DAQQQKRSIQEELQQLRQSS--------EAEIQAKARQAEAAE-----RSRLR-IEEEIR 1482
Query: 538 LMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGEAGGPPSTREAELKLRLRLVEEE 597
++R ++ ++++ E ELQ R + + EA + EAE +LR R V++E
Sbjct: 1483 VVRLQLEATERQRGGAEGELQALR-------ARAEEAEAQKRQAQEEAE-RLR-RQVQDE 1533
Query: 598 ANILGRKIVELEVENRGLKAELDDLRGDDFNGSANPLMREQSESLSELRQHLQLVEDETE 657
+ ++ E+E+ +R +KAE + R A +R Q+E +L + E E
Sbjct: 1534 SQ--RKRQAEVELASR-VKAEAEAAREKQRALQALEELRLQAEEAER-----RLRQAEVE 1585
Query: 658 LLRRNVADLEEQNKRITAELNKYKYKSGGHDSARHHDNAKTEALQEELKAARLQINELSG 717
R+ LE + AEL + ++ A+ E +E A Q+ E +
Sbjct: 1586 RARQVQVALETAQRSAEAELQSKR-------ASFAEKTAQLERSLQEEHVAVAQLREEAE 1638
Query: 718 KVMQLQYE----NRVLMSNMQRYDLASHLGIRGSPRDSDAESDAGKKESDDDSRPPHRKR 773
+ Q Q E ++R+ L ++ +R + + +++ + + +R
Sbjct: 1639 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1698
Query: 774 EGPIGGESDSEEVR 787
E G+++ + VR
Sbjct: 1699 EARRRGKAEEQAVR 1712
>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
Length = 2028
Score = 74.7 bits (182), Expect = 4e-13
Identities = 82/397 (20%), Positives = 176/397 (44%), Gaps = 48/397 (12%)
Query: 346 LQEQEEMQEEMEKLREEN----ETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELER 401
++E+E++Q +ME L+ + + L+ E D L M +R+ +++++ E +
Sbjct: 535 IREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKA 594
Query: 402 ANKNCRILQYRLRKAE---RKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENV 458
++ +L + E R+ R + + GE LE++L+ ++ + RL ++ ++
Sbjct: 595 LHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSL 654
Query: 459 EEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPT 518
E T ++ E L + +++ + L+ L+ ++ +SL+ G
Sbjct: 655 E----TATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEG---------------L 695
Query: 519 EEDNEDL---KCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGE 575
E DN+ L +L+ + E K+A++++E + E E ++ R DL L K
Sbjct: 696 ERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNV-DLLKALGK-- 752
Query: 576 AGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDLRGDDFNGSANPLM 635
+ L+L + V E L + + + + L++EL +L + +
Sbjct: 753 -------KSERLELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEAE------RQAL 799
Query: 636 REQSESLSELRQHLQLVEDETELLRRNVADLEEQNKRITAELNKYKYKSGGHDSARHHDN 695
R E+L L+ E + + L + VA LE+ K + E + + D+
Sbjct: 800 RRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDST 859
Query: 696 AKTEALQEELKAARLQI---NELSGKVMQLQYENRVL 729
AK A+++E +A ++ + +GK+ +L+ +NR L
Sbjct: 860 AKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDL 896
Score = 65.5 bits (158), Expect = 2e-10
Identities = 83/392 (21%), Positives = 169/392 (43%), Gaps = 56/392 (14%)
Query: 348 EQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERANKNCR 407
E +++ E++K+++EN L + R DE+ E A +++ + EL R +
Sbjct: 283 EVDQLVLELQKVKQENIQLAADARSARAYRDELDS--LREKANRVERLELELTRCKEKLH 340
Query: 408 ILQYRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTTED 467
+ + KA + LR I+ + + LE+ L A+ ++H E
Sbjct: 341 DVDFY--KARMEELREDNIILIETKAM--LEEQLTAARARGDKVHE-----------LEK 385
Query: 468 ENEKLRQQLIEVEIAKQALQNELEKMKE--LSLKRRGSKDLPKSEKKAQQTPTEEDNEDL 525
EN +L+ +L ++E+ + + +E++ E + L+ + + +S + N DL
Sbjct: 386 ENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADL 445
Query: 526 K--CQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGEAGGPPSTR 583
+ FV E ++ K++KE + +Q R D+ L E+G
Sbjct: 446 SDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLR------DASLVLEESG------ 493
Query: 584 EAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDLRGDDFNGSANPLMREQSESLS 643
L+ +E+E + L +KI +L+ + E + D + L+RE+ + S
Sbjct: 494 -----LKCGELEKENHQLSKKIEKLQTQ-----LEREKQSNQDLETLSEELIREKEQLQS 543
Query: 644 ELRQHLQLVEDETELLRRNVADLEEQNKRITAELNKYKYKSGGHDSARHHDNAKTEALQE 703
++ L D+ R + DLE++ + + + +S AR D +++
Sbjct: 544 DMET---LKADKA----RQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKD------VEK 590
Query: 704 ELKAARLQINELSGKVMQLQYENRVLMSNMQR 735
E KA + E +GK+ QL++E R L ++++
Sbjct: 591 ENKALHQTVTEANGKLSQLEFEKRQLHRDLEQ 622
Score = 63.9 bits (154), Expect = 7e-10
Identities = 96/454 (21%), Positives = 187/454 (41%), Gaps = 73/454 (16%)
Query: 347 QEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQE------------ 394
+ E+++ E+++L+EEN L ++ L T +++ E QL+
Sbjct: 628 ERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQN 687
Query: 395 ---MRHELERANKNCRILQYRLRKAERKRLRYAQTG----EIDGELLRSLEQDLKVAKDV 447
LER NK LR+ + +R+ T E + + L +++L+ D+
Sbjct: 688 VSLQLEGLERDNKQLDAENLELRRLV-ETMRFTSTKLAQMERENQQLEREKEELRKNVDL 746
Query: 448 SVRLHHELENVEEKRTTTEDENEKLRQ--------------QLIEVEIAKQALQNELEKM 493
L + E +E + EN +L+Q +L E+E +QAL+ +LE +
Sbjct: 747 LKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEAERQALRRDLEAL 806
Query: 494 KELSLKRRGS-KDLPKSEKKAQQTPTEE---DNEDLKCQLQFVKEEAAL--MRKKMAKID 547
+ + + G+ KD E++ Q ++ + E + Q ++A L K++ ++
Sbjct: 807 RLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVE 866
Query: 548 KEKDRFEHELQKYRSFYGDLDSPLPKGEAGGPPSTREAELKLR-LRLVEEEANILGRKIV 606
KE + EL + R D L + E T++ + R L + E+ + K
Sbjct: 867 KESRALDKELARCR----DAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQ 922
Query: 607 EL---------EVENRGLKAELDDLRGDDFNGSANPLMREQSESLSELRQHLQLVEDETE 657
+L E+E GL EL L +D +GS + + S L+ L + E++
Sbjct: 923 QLSSELDKLSQELEKVGLNREL--LLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIV 980
Query: 658 LLRRNVADLEEQNKRITAELNKYKYK---------SGGH-DSARHHDNAKTEALQEELKA 707
LL + + N+++ +EL K + G H ++ H KT A + +A
Sbjct: 981 LLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEA 1040
Query: 708 -------ARLQINELSGKVMQLQYENRVLMSNMQ 734
A +++ + + ++L+ N L + Q
Sbjct: 1041 WGPGHKEATMELLRVKDRAIELERNNAALQAEKQ 1074
Score = 42.4 bits (98), Expect = 0.002
Identities = 92/452 (20%), Positives = 176/452 (38%), Gaps = 76/452 (16%)
Query: 346 LQEQEEMQEEMEKLRE-ENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERANK 404
LQE + + K+ E NE+ ++ E + + EE A +++ EL+ K
Sbjct: 946 LQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKK 1005
Query: 405 NCRILQYRLRKAERKRLRYAQTG------------------EIDGELLRSLEQDLKVAKD 446
C L+ + + + + E ELLR ++ +++ ++
Sbjct: 1006 ECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERN 1065
Query: 447 VSVRLHHELENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDL 506
+ L E + ++E+ E +N Q++ ++ LQ ++ + K +
Sbjct: 1066 -NAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENST 1124
Query: 507 PKSEKKA----------QQTPTEEDNEDLKCQLQFVKE--EAALMRKKMAKIDKEKDRFE 554
S+ A T E +NE L+ Q + + EA L + E+ E
Sbjct: 1125 LSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAE 1184
Query: 555 HE-LQKYRSFYGDLDSPLPK-----GEAGGPPSTREAELKLRLRLVEEEANILGRKIVEL 608
+E L + S L L GE G R+AEL+ R +++ E L ++
Sbjct: 1185 YEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTN 1244
Query: 609 EV---ENRGLKAELD-------DLRGD-------------DFNGSANPLMREQS--ESLS 643
+ EN+ L+ ELD L+G+ N + L R Q+ + L
Sbjct: 1245 ALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELK 1304
Query: 644 ELRQHLQL----VEDETELLRRNVADLEEQNKRITAEL------NKYKYKSGGHDSARHH 693
E Q + + +++ ELL R +LEE+N + +++ N+ + + ++H
Sbjct: 1305 EQHQTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYH 1364
Query: 694 DNAKTEALQEELKAARLQINELSGKVMQLQYE 725
+ K ++L A R +L K+M QY+
Sbjct: 1365 EEQKQYI--DKLNALRRHKEKLEEKIMD-QYK 1393
Score = 38.5 bits (88), Expect = 0.030
Identities = 43/223 (19%), Positives = 86/223 (38%), Gaps = 28/223 (12%)
Query: 342 HPQQLQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELER 401
H + E E +Q + E+L E L + + L T HE +
Sbjct: 1143 HTAKETENESLQRQQEQLTAAYEALLQDHEHLGT--------------------LHERQS 1182
Query: 402 ANKNCRILQYRLRKAERKRLR--YAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVE 459
A I Q+ K + L + + GE G++L+ + +L+ + V L+ +
Sbjct: 1183 AEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKR-KAELEEREKVLTTEREALQQEQ 1241
Query: 460 EKRTTTEDENEKLRQQLIEVEIAKQALQNELEKM----KELSLKRRGSKDLPKSEKKAQQ 515
EN++LR +L V L+ E E++ KEL ++ L + +A+
Sbjct: 1242 RTNALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQ-LELNRWQARF 1300
Query: 516 TPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQ 558
+E ++ + L + L+ + +++E ++Q
Sbjct: 1301 DELKEQHQTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQIQ 1343
Score = 31.6 bits (70), Expect = 3.7
Identities = 51/240 (21%), Positives = 79/240 (32%), Gaps = 36/240 (15%)
Query: 18 PAAAATEARLHPEGSSRKQQRAQSPA--RPRDSSLRQTIAATRSPVGAGTKLNSVRQQQL 75
P TEA P + R+ Q QS + RPR + + A S + ++ S+ L
Sbjct: 1753 PNFRLTEAEAPPSVAPRQAQPPQSLSLGRPRQAPVPPASHAPASRSASLSRAFSLASADL 1812
Query: 76 QQQ---QQQGNKTGSRTGPPASIRGGGGGAEKATPLAPKGAAPGAVQPVAGAEAAPAATL 132
+ + ++ + G P ++ G G+ AP + A E P
Sbjct: 1813 LRASGPEACKQESPQKLGAPEALGGRETGSHTLQSPAPPSSHSLA------RERTPLVGK 1866
Query: 133 AALGGRRPGPPEEP----------PRELESVPSKLGEPPPLGEGGGGGGEGGGAGGGS-- 180
A + PGP P P+E P P G G G+G S
Sbjct: 1867 AGSSCQGPGPRSRPLDTRRFSLAPPKEERLAPLHQSATAPAIATAGAGAAAAGSGSNSQL 1926
Query: 181 -------GEREGGAPQPPPPRGWRG------KGVRAQQRGGSGGEGASPSPSSSSAGKTP 227
P+ PP G G+ + G G+G S + S G++P
Sbjct: 1927 LHFSPAAAPAARTKPKAPPRSGEVATITPVRAGLSLSEGDGVPGQGCSEGLPAKSPGRSP 1986
>gi|4502443 dystonin isoform 1e precursor [Homo sapiens]
Length = 2649
Score = 73.6 bits (179), Expect = 8e-13
Identities = 90/410 (21%), Positives = 180/410 (43%), Gaps = 44/410 (10%)
Query: 344 QQLQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMR--DTFFEEDACQLQEMRHELER 401
+ +QE ++++ + E E+L +E +L+ E+D + E++ L H R
Sbjct: 1454 EAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSF-R 1512
Query: 402 ANKNCRILQYRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEEK 461
K LQ RK++ + ++ ++ E +LL++++ + K D RL+ ELE E
Sbjct: 1513 DEKELERLQICQRKSDHLKEQFEKSHE---QLLQNIKAE-KENNDKIQRLNEELEKSNEC 1568
Query: 462 RTTTEDENEKLRQQLIEVEIAKQALQNELE-----------KMKELSLKRRGSKDLPKS- 509
+ + E+L +Q E ++ Q +Q E E + + L ++ G KD +S
Sbjct: 1569 AEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRST 1628
Query: 510 -EKKAQQTPTEED-NEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDL 567
E +QT TE+D +KC + + + L+ + K D++ ++ ++ R+ +L
Sbjct: 1629 NEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAEL 1688
Query: 568 DSPLPKGEAGGP----PSTREAELKLRLRLVEEEANI-------LGRKIVELEVENRGLK 616
++ + G + EL RL+ V++E ++ RK+V + E+ K
Sbjct: 1689 NASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFK 1748
Query: 617 AELDDLRGDDFNGSANPLMREQ---SESLSELRQHLQLVEDETELLRRNVADLEEQNKRI 673
++F LM + +S +R ++ E + N E K +
Sbjct: 1749 QS-----AEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKEL 1803
Query: 674 TAELNKYK--YKSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVMQ 721
+L +Y+ + G H A H+ K + L++EL A + ++ L K+ Q
Sbjct: 1804 ERQLQQYREQMQQGQHMEANHYQ--KCQKLEDELIAQKREVENLKQKMDQ 1851
Score = 59.7 bits (143), Expect = 1e-08
Identities = 87/406 (21%), Positives = 173/406 (42%), Gaps = 49/406 (12%)
Query: 347 QEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERANKNC 406
+++ ++EE+ K+RE E +ELR + + D LQ++R E E
Sbjct: 1152 KQKSRVEEELPKVREAAE------NELRKQQRNVEDI-------SLQKIRAESEAK---- 1194
Query: 407 RILQYRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVA--KDVSVRLHHELENVEEKRTT 464
QYR R + A E++ ++E + K A ++ + ++LE R T
Sbjct: 1195 ---QYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRT 1251
Query: 465 TEDENEKLRQQLIEVEIAKQALQNELEKMKE-----LSLKRRGSKDLPKSEKKAQQTPTE 519
ED ++ L ++E K L EL + ++ L L ++ KDL ++ A++ E
Sbjct: 1252 LEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKE 1311
Query: 520 EDNEDLKC-----QLQFVKEEAAL---------MRKKMAKIDKEKDRFEHELQKYRSFYG 565
+ +L+ ++Q+ E AL + + + +E D+ + ++ +
Sbjct: 1312 KQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDK--QKAEELKQQVD 1369
Query: 566 DLDSPLPKGEAGGPPSTREAE-LKLRLRLVEEEANILGRKIVELEVENRGLKAELD--DL 622
+L + K E T E L+L EE+A +L K+ E R LK EL+ D
Sbjct: 1370 ELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQ 1429
Query: 623 RGDDFNGSANPLMREQSESLSELRQHLQLVEDETELLRRNVADLEEQNK---RITAELNK 679
++ L R+ +++ + + +Q D ++ R +LE N ++ E+++
Sbjct: 1430 AEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDR 1489
Query: 680 YKYKSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVMQLQYE 725
+ H N++ + ++E + RLQI + ++ Q+E
Sbjct: 1490 ITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFE 1535
Score = 58.5 bits (140), Expect = 3e-08
Identities = 92/419 (21%), Positives = 170/419 (40%), Gaps = 49/419 (11%)
Query: 346 LQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTF---FEEDACQLQEMRHELERA 402
++E+E + E+E++R+ L E + R ++E F EE+ + + L+R
Sbjct: 1204 VREKEAAERELERVRQ----LTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRK 1259
Query: 403 NKNCRILQYRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVE-EK 461
+ + L+ + K + R E +L++ +E+DL K V+ + E + +E E
Sbjct: 1260 DLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEA 1319
Query: 462 RTTTEDENEKLRQQLIEVEIAKQA--------LQNELEKMKELSLKRRGSKDLPKSEKKA 513
R + R+ + V QA LQ E +K K LK++ +L + +KA
Sbjct: 1320 RRKITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVD-ELTAANRKA 1378
Query: 514 QQTPTEEDNEDLKCQLQFV--KEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPL 571
+Q E E QL+ +E+A L++ K+ + + + EL++
Sbjct: 1379 EQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELER------------ 1426
Query: 572 PKGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDLRGDDFNGSA 631
K +A S + EL +L +A ++ +L+ R + EL+ L N
Sbjct: 1427 -KDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESL-----NHEK 1480
Query: 632 NPLMRE----------QSESLSELRQHLQLVEDETELLRRNVADLEEQNKRITAELNKYK 681
L RE +++ L + DE EL R + + ++ + + K
Sbjct: 1481 GKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQIC--QRKSDHLKEQFEKSH 1538
Query: 682 YKSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVMQLQYENRVLMSNMQRYDLAS 740
+ + A +N K + L EEL+ + L KV +L +N MQR S
Sbjct: 1539 EQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAES 1597
Score = 49.3 bits (116), Expect = 2e-05
Identities = 79/413 (19%), Positives = 161/413 (38%), Gaps = 61/413 (14%)
Query: 352 MQEEMEKLREENETLKNEIDEL----RTEMDEMRDTFFEEDACQLQEMRHELERANKNCR 407
+Q+E +K ++ E LK ++DEL R +MR+ +E +A QL++ E + R
Sbjct: 1352 LQQEHDK--QKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSE-----EKAR 1404
Query: 408 ILQYRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTTED 467
+L+ +L + LR L+ +L+ +L + + T
Sbjct: 1405 LLKDKLDETNNT--------------LRCLKLELERKDQAEKGYSQQLRELGRQLNQTTG 1450
Query: 468 ENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTEEDNEDLKC 527
+ E+ Q+ +++ K+ Q ELE + +G E++ + L
Sbjct: 1451 KAEEAMQEASDLKKIKRNYQLELESLNH----EKGKLQREVDRITRAHAVAEKNIQHLNS 1506
Query: 528 QLQFVKEEAALMRKKMA--KIDKEKDRFEHELQKYRSFYGDLDSPLPKGEAGGPPSTREA 585
Q+ ++E L R ++ K D K++FE ++ L +A + +
Sbjct: 1507 QIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQL----------LQNIKAEKENNDKIQ 1556
Query: 586 ELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDLRGDDFNGSANPLMREQS------ 639
L L E A +L +K+ EL +N K + ++ + S N ++ +Q+
Sbjct: 1557 RLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAE----SENIVLEKQTIQQRCE 1612
Query: 640 ----------ESLSELRQHLQLVEDETELLRRNVADLEEQNKRITAELNKYKYKSGGHDS 689
+ L +HL + +R + LEE + ++++K K +
Sbjct: 1613 ALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNI 1672
Query: 690 ARHHDNAKTEALQEELKAARLQINELSGKVMQLQYENRVLMSNMQRYDLASHL 742
+ + L EL A++ + KV Q + + L + +++ HL
Sbjct: 1673 IIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHL 1725
Score = 43.1 bits (100), Expect = 0.001
Identities = 77/414 (18%), Positives = 180/414 (43%), Gaps = 40/414 (9%)
Query: 349 QEEMQEEMEKLREEN--ETLKNEIDELRTEMDEMRDTF--FEEDACQLQEMRHELERANK 404
+ ++ EE + ++N E L + + + R+E+DE R F E++ + + + E+ + K
Sbjct: 866 ETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYK 925
Query: 405 NCRI-LQYRLRKAERKRLRYAQTG-EIDGEL--LRSLEQDLKVAKDVSVRLHHELENVEE 460
+ + KA++ R+ +ID L L + + LK +D +H L++ +
Sbjct: 926 ERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDT----YHPLDDWIQ 981
Query: 461 KRTTTE---DENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTP 517
+ TT+ EN+ + + ++ +Q + + E+ +K+ + K ++ T
Sbjct: 982 QVETTQRKIQENQPENSKTLATQLNQQKML-----VSEIEMKQSKMDECQKYAEQYSATV 1036
Query: 518 TEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPK--GE 575
+ + + + + ++ + ++++ ++ D E R+ Y L + + +
Sbjct: 1037 KDYELQTMTYRAMVDSQQKSPVKRR--RMQSSADLIIQEFMDLRTRYTALVTLMTQYIKF 1094
Query: 576 AGGPPSTREAELKLRLRLVEEE---ANILGRKIVELEVENRGLKAELDDLRGDDFNGSAN 632
AG E E R + E +++L R+ + +EN L ++ +L
Sbjct: 1095 AGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATV-LENSKLTGKISELER-----MVA 1148
Query: 633 PLMREQSESLSELRQHLQLVEDETELLRRNVADLEEQNKRITAELNKYKYK-----SGGH 687
L +++S EL + + E+E +RNV D+ Q R +E +Y+ +
Sbjct: 1149 ELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKE 1208
Query: 688 DSARHHDNAKTEALQEELKAARLQINELS--GKVMQLQYENRVLMSNMQRYDLA 739
+ R + + ++ E K A ++ N L+ ++ + + R L +++R DL+
Sbjct: 1209 AAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLS 1262
Score = 41.2 bits (95), Expect = 0.005
Identities = 30/139 (21%), Positives = 65/139 (46%), Gaps = 16/139 (11%)
Query: 347 QEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERANKNC 406
Q EE +++MEKL E +N+I +R + ++ E RA +N
Sbjct: 1749 QSAEEFRKKMEKLMESKVITENDISGIRLDF---------------VSLQQENSRAQENA 1793
Query: 407 RILQYRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTTE 466
++ + +++ ER+ +Y + + + + Q + +D + E+EN+++K
Sbjct: 1794 KLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQI 1853
Query: 467 DENEKLRQQLIEVEIAKQA 485
E+E + L++ EI K++
Sbjct: 1854 KEHEH-QLVLLQCEIQKKS 1871
Score = 32.3 bits (72), Expect = 2.1
Identities = 37/158 (23%), Positives = 74/158 (46%), Gaps = 24/158 (15%)
Query: 345 QLQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDAC--QLQEMRHELERA 402
++ EQE++++E+E+L+++ T+ N+ +E FF + A + +R EL
Sbjct: 779 RITEQEKLKKELERLKDDLGTITNKCEE-----------FFSQAAASSSVPTLRSELNVV 827
Query: 403 NKNCRILQYRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEEKR 462
+N + Y + +L+ +L++ + + K +L E E V +
Sbjct: 828 LQNMNQV-YSMSSTYIDKLKTVNL------VLKNTQAAEALVKLYETKLCEE-EAVIADK 879
Query: 463 TTTEDENEKLRQQLIEVEIAKQ---ALQNELEKMKELS 497
E+ L+Q EV+ +Q AL++EL+K K +S
Sbjct: 880 NNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAIS 917
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 73.6 bits (179), Expect = 8e-13
Identities = 87/408 (21%), Positives = 182/408 (44%), Gaps = 52/408 (12%)
Query: 346 LQEQEEMQEEMEKLREENETLKNEI---DELRTEMDEMRDTFFEED---ACQLQEMRHEL 399
L + E ++EM ++EE E K E+ + R E++E T +E Q+Q L
Sbjct: 843 LLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSL 902
Query: 400 ERANKNCRILQYRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVE 459
A + C L + E K ++ + + + ++++ L + +E
Sbjct: 903 ADAEERCDQLIKTKIQLEAK--------------IKEVTERAEDEEEINAELTAKKRKLE 948
Query: 460 EKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTE 519
++ + + + + L L +VE K A +N+++ + E + EKKA Q +
Sbjct: 949 DECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQ 1008
Query: 520 EDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGEAGGP 579
+ +DL+ + +++ + K K++++ D E L++ + DL+ K E G
Sbjct: 1009 QTLDDLQAE----EDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLE-GDL 1063
Query: 580 PSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDLRGDDFNGSANPLMREQS 639
+E+ + +E + L K+ + E E GL+++++D L +
Sbjct: 1064 KLAQESTMD-----IENDKQQLDEKLKKKEFEMSGLQSKIED---------EQALGMQLQ 1109
Query: 640 ESLSELRQHLQLVEDETELLRRNVADLEEQNKRITAELNKYKYK---SGGHDSARHHDNA 696
+ + EL+ ++ +E+E E R + A E+Q ++ EL + + +GG SA+ N
Sbjct: 1110 KKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNK 1169
Query: 697 KTEA----LQEELKAARLQINELSGKVMQLQYENRVL-----MSNMQR 735
K EA ++ +L+ A LQ +E + ++ ++ + V + N+QR
Sbjct: 1170 KREAEFQKMRRDLEEATLQ-HEATAATLRKKHADSVAELGEQIDNLQR 1216
Score = 66.2 bits (160), Expect = 1e-10
Identities = 82/380 (21%), Positives = 171/380 (45%), Gaps = 50/380 (13%)
Query: 347 QEQEEMQEEMEKLREENETLKNE----IDELRTEMDEMRDTFFEEDACQLQEMRHELERA 402
+E + E + KL +E + L+ +D+L+ E D++ + +L++ +LE +
Sbjct: 984 EEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT--LTKAKIKLEQQVDDLEGS 1041
Query: 403 NKNCRILQYRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEEKR 462
+ + ++ L +A+RK LE DLK+A++ ++ + ++ + ++EK
Sbjct: 1042 LEQEKKIRMDLERAKRK-----------------LEGDLKLAQESTMDIENDKQQLDEKL 1084
Query: 463 TTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTEEDN 522
E E L+ ++ + + LQ +K+KEL + ++ ++E +A + E+
Sbjct: 1085 KKKEFEMSGLQSKIEDEQALGMQLQ---KKIKELQARIEELEEEIEAE-RASRAKAEKQR 1140
Query: 523 EDLKCQLQFVK---EEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGEAGGP 579
DL +L+ + EEA +++K++ E E QK R DL+ + EA
Sbjct: 1141 SDLSRELEEISERLEEAGGATSAQIEMNKKR---EAEFQKMRR---DLEEATLQHEA--T 1192
Query: 580 PSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDLRGD-----DFNGSANPL 634
+T + + + E+ + L R +LE E +K E+DDL + G+ +
Sbjct: 1193 AATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKM 1252
Query: 635 MREQSESLSELRQHLQLVEDETELLRRNVADLEEQNKRITAELNKYKYKSGGHDSARHHD 694
R + LSE ++ + E +R + DL Q R+ E +Y + D+
Sbjct: 1253 CRALEDQLSE-------IKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQL 1305
Query: 695 NAKTEALQEELKAARLQINE 714
+ +A ++++ + Q+ E
Sbjct: 1306 SRGKQAFTQQIEELKRQLEE 1325
Score = 59.7 bits (143), Expect = 1e-08
Identities = 84/387 (21%), Positives = 176/387 (45%), Gaps = 49/387 (12%)
Query: 351 EMQEEMEKLREEN----ETLKNEID-ELRTEMDEMRDTFFEEDACQLQEMRHELERANKN 405
E EE+++++ + E++++ +D E+R+ D +R ++ L EM +L AN
Sbjct: 1582 EKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIR--LKKKMEGDLNEMEIQLNHAN-- 1637
Query: 406 CRILQYRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTT 465
R A Y T I + L+ L+ +D L +L VE +
Sbjct: 1638 --------RMAAEALRNYRNTQAILKDTQLHLDDALRSQED----LKEQLAMVERRANLL 1685
Query: 466 EDENEKLRQQLIEVEIAKQALQNEL-EKMKELSLKRRGSKDLPKSEKKAQQTPTEEDNED 524
+ E E+LR L + E +++ + EL + + + L + L ++KK E D
Sbjct: 1686 QAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKL-----ETDISQ 1740
Query: 525 LKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGEAGGPPSTRE 584
++ +++ + +EA +K K + EL+K + D + L + + + ++
Sbjct: 1741 IQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQ----DTSAHLERMKKNLEQTVKD 1796
Query: 585 AELKLRLRLVEEEANILGRK-IVELEVENRGLKAELDDLRGDDFNGSANPLMREQSESLS 643
L+ RL E+ A G+K I +LE R L+ E++ + + E++
Sbjct: 1797 --LQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQ------------KRNVEAVK 1842
Query: 644 ELRQHLQLVED---ETELLRRNVADLEEQNKRITAELNKYKYKSGGHDSARHHDNAKTEA 700
LR+H + V++ +TE R+N+ L++ ++ A++ YK ++ + + + +K
Sbjct: 1843 GLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRR 1902
Query: 701 LQEELKAARLQINELSGKVMQLQYENR 727
+Q EL+ A + + +V +L+ ++R
Sbjct: 1903 IQHELEEAEERADIAESQVNKLRVKSR 1929
Score = 55.8 bits (133), Expect = 2e-07
Identities = 129/642 (20%), Positives = 258/642 (40%), Gaps = 103/642 (16%)
Query: 348 EQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDAC-------QLQEMRHELE 400
++EE Q + L + L+ E E ++DE +DT + + Q++E++ +LE
Sbjct: 1266 KEEEQQRLINDLTAQRARLQTESGEYSRQLDE-KDTLVSQLSRGKQAFTQQIEELKRQLE 1324
Query: 401 RANKNCRILQYRLRKAERK----RLRYAQTGEIDGELLRSLEQ-DLKVAK------DVSV 449
K L + L+ + R +Y + E EL R++ + + +VA+ ++
Sbjct: 1325 EEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAI 1384
Query: 450 RLHHELENVEEKRTT----TEDENEKLRQQLIEVEIAKQALQNELEK-MKELSLKRRGSK 504
+ ELE ++K E+ E + + +E KQ LQNE+E M ++
Sbjct: 1385 QRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACA 1444
Query: 505 DLPKSEKKAQQTPTE--EDNEDLKCQLQFVKEEAALMRKKMAKI----DKEKDRFEHELQ 558
L K ++ + E + E+ +L+ ++E+ + ++ KI ++ D+ E +
Sbjct: 1445 ALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKR 1504
Query: 559 KYRSFYGDLDSPLPKGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELE--VENRGLK 616
+ ++ ++ + GG R EL+ + VE+E + L + E E +E+ K
Sbjct: 1505 ENKNLQQEISDLTEQIAEGG---KRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGK 1561
Query: 617 AELDDLRGDDFNGSANPLMREQSESLSEL-RQHLQLVED-----ETELLRRNVA------ 664
L + + + E+ E + ++ R H+++VE + E+ RN A
Sbjct: 1562 ILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKK 1621
Query: 665 ---DLEEQ-------NKRITAELNKYKYKSG-GHDSARHHDNA--KTEALQEELKAARLQ 711
DL E N+ L Y+ D+ H D+A E L+E+L +
Sbjct: 1622 MEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERR 1681
Query: 712 INELSGKVMQL-----QYENRVLMSNMQRYDLASHLGIRGSPRDSDAESDAGKKESDDDS 766
N L ++ +L Q E ++ + D + + + + S + KK+ + D
Sbjct: 1682 ANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINT---KKKLETDI 1738
Query: 767 RPPHRKREGPIGGESDSEEVRNIRCLTPTRSFYPAPGPWPKSFSDRQQMKDIRSEAERLG 826
+ E I ++EE + + +T + ++ +D + ER+
Sbjct: 1739 SQIQGEMEDIIQEARNAEE-KAKKAITDAAMM----------AEELKKEQDTSAHLERMK 1787
Query: 827 KTIDRLIADTSTIITEARIYVANG-------------DLFGLMDEEDDGS-----RIREH 868
K +++ + D + EA G +L G ++ E + +R+H
Sbjct: 1788 KNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKH 1847
Query: 869 -----ELLYRINAQMKAFRKELQTFIDRLEVPKSADDRGAEE 905
EL Y+ K + LQ +D+L+ + R AEE
Sbjct: 1848 ERKVKELTYQTEEDRKNILR-LQDLVDKLQAKVKSYKRQAEE 1888
Score = 46.2 bits (108), Expect = 1e-04
Identities = 55/287 (19%), Positives = 131/287 (45%), Gaps = 29/287 (10%)
Query: 346 LQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERANKN 405
L+ QE+++E++ + L+ EI+ELR +++ E + ++ E EL A++
Sbjct: 1665 LRSQEDLKEQLAMVERRANLLQAEIEELRATLEQ------TERSRKIAE--QELLDASER 1716
Query: 406 CRILQ-YRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEEKRTT 464
++L K+ +I GE + + Q+ + A++ + + + + E+
Sbjct: 1717 VQLLHTQNTSLINTKKKLETDISQIQGE-MEDIIQEARNAEEKAKKAITDAAMMAEELKK 1775
Query: 465 TEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTEEDNED 524
+D + L + +E + LQ+ L++ ++L+LK G K + K E + ++ E ++E
Sbjct: 1776 EQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALK-GGKKQIQKLEARVRELEGEVESEQ 1834
Query: 525 ---------LKCQLQFVKE---EAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLP 572
L+ + VKE + RK + ++ D+ + +++ Y+ + +
Sbjct: 1835 KRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAE---- 1890
Query: 573 KGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAEL 619
E ++ ++ L EE A+I ++ +L V++R + ++
Sbjct: 1891 --EQSNVNLSKFRRIQHELEEAEERADIAESQVNKLRVKSREVHTKI 1935
Score = 37.7 bits (86), Expect = 0.051
Identities = 42/185 (22%), Positives = 80/185 (43%), Gaps = 15/185 (8%)
Query: 301 ETLAVASASPMAAAAEGPQQSAEGSASGGGMQAAAPPSSQPHPQQLQEQEEM-----QEE 355
E A + + A AE ++ + SA M+ + + +L E E++ +++
Sbjct: 1756 EEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQ 1815
Query: 356 MEKLREENETLKNEID-ELRTEMDEMRDTFFEEDACQLQEMRHELERANKNCRILQYRLR 414
++KL L+ E++ E + ++ ++ E +++E+ ++ E KN LQ +
Sbjct: 1816 IQKLEARVRELEGEVESEQKRNVEAVKGLRKHER--KVKELTYQTEEDRKNILRLQDLVD 1873
Query: 415 KAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTTEDENEKLRQ 474
K + K Y + E E+ V R+ HELE EE+ E + KLR
Sbjct: 1874 KLQAKVKSYKRQAE-------EAEEQSNVNLSKFRRIQHELEEAEERADIAESQVNKLRV 1926
Query: 475 QLIEV 479
+ EV
Sbjct: 1927 KSREV 1931
>gi|33457336 chromosome 14 open reading frame 4 [Homo sapiens]
Length = 796
Score = 73.6 bits (179), Expect = 8e-13
Identities = 92/372 (24%), Positives = 133/372 (35%), Gaps = 45/372 (12%)
Query: 37 QRAQSPARP-----RDSSLRQTIAATRSPVGAGTKLNSVRQQQLQQQQQQGNKTGSRTGP 91
Q +SP P + +L AA + A + +QQQ QQQQQQ + +
Sbjct: 65 QDGRSPGPPPPVGVKTVALSAKEAAAAAAAAAAAAAAAQQQQQQQQQQQQQQQQQQQQQQ 124
Query: 92 PASIRGGGGGAEKATPLAPKGAAPGAVQPVAGAEAAPAATLAALGGRRPGPPEEPPRELE 151
+ G ++ A AP G + A A AA AA + PP
Sbjct: 125 QQQLNHVDGSSKPAVLAAPSGLERYGLSAAAAAAAAAAAAVEQRSRFEYPPP-------- 176
Query: 152 SVPSKLGEPPPLGEGGGGGGEGGGAGGGSGEREGGAPQPPPPRGWRGKGVRAQQRGGSGG 211
P LG G GG G P+P P G
Sbjct: 177 --------PVSLGSSSHTARLPNGLGG-----PNGFPKPTPEEG--------------PP 209
Query: 212 EGASPSPSSSSAGKTPGTGSRNSGSGVAGGGSGGGGSYWKEGCLQSELIQFHLKKERAAA 271
E SP+SSSA + + G V G + GGG + + L Q L +AA
Sbjct: 210 ELNRQSPNSSSAAASVASRRGTHGGLVTGLPNPGGGGGPQLTVPPNLLPQTLLNGPASAA 269
Query: 272 AAAAAQMHAKNGGGSSSRSSP-VSGPPAVCETLAVASASPMAAAAEGPQQSAEGSASGGG 330
HA G + + P G PA SA+ +A++ AE GG
Sbjct: 270 VLPPPPPHALGSRGPPTPAPPGAPGGPACLGGTPGVSATSSSASSSTSSSVAEVGVGAGG 329
Query: 331 MQAAAPPSSQPHPQQLQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDAC 390
+ P S Q +E +E Q E L E +E+L+N +E ++ +RDT C
Sbjct: 330 KR----PGSVSSTDQERELKEKQRNAEALAELSESLRNRAEEWASKPKMVRDTLLTLAGC 385
Query: 391 QLQEMRHELERA 402
E+R + + +
Sbjct: 386 TPYEVRFKKDHS 397
Score = 40.0 bits (92), Expect = 0.010
Identities = 44/139 (31%), Positives = 50/139 (35%), Gaps = 17/139 (12%)
Query: 107 PLAPKGAAPGAVQPVAGAEAAPAATLAALGGRRPGPPEEPPRELESVPSKLGEPPPLGEG 166
P AP G GA+ P AAP+ AA R+ EPP E KLGE +
Sbjct: 518 PSAPPGT--GALPP-----AAPSGRGAAASLRKRKASPEPPDSAEGA-LKLGEEQQRQQW 569
Query: 167 GGGGGEG------GGAGGGSGEREGGAPQPPPPRGWRGKGVRAQQRGGSGGEGASPSPSS 220
E G G GG P PPPP G R + G SP +
Sbjct: 570 MANQSEALKLTMSAGGFAAPGHAAGGPPPPPPPLGPHSN--RTTPPESAPQNGPSPMAAL 627
Query: 221 SSAGKTPGTG-SRNSGSGV 238
S T GT S GS V
Sbjct: 628 MSVADTLGTAHSPKDGSSV 646
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 72.4 bits (176), Expect = 2e-12
Identities = 112/521 (21%), Positives = 220/521 (42%), Gaps = 67/521 (12%)
Query: 251 KEGCLQSELIQFHLKKERAAAAAAAAQMHAKNGGGSSSR-SSPVSGPPAVCETL--AVAS 307
K+ L+SEL++ H + A++ G + A E L AV
Sbjct: 1307 KQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVE 1366
Query: 308 ASPMAAAAEGPQQSAEGSASGGGMQAAAPPSSQPHPQQLQEQEEMQEEMEKLREEN---- 363
A A+AA ++ + S ++ S + Q LQEQ E++ K +EN
Sbjct: 1367 ARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALL 1426
Query: 364 -----------ETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELE------RANKNC 406
ETL+ +I EL + EM+ E + L++ E++ + + C
Sbjct: 1427 TQTLAEREEEVETLRGQIQELEKQR-EMQKAALELLSLDLKKRNQEVDLQQEQIQELEKC 1485
Query: 407 RILQYRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTTE 466
R + L A ++R Q + E +R LE+D + ++V L H+L +E+K E
Sbjct: 1486 RSVLEHLPMAVQER---EQKLTVQREQIRELEKDRETQRNV---LEHQLLELEKKDQMIE 1539
Query: 467 DEN---EKLRQQLIEVEIAKQALQNELEKM---KELSLKRRGSKDLPKSEKKAQQTPTEE 520
+ + L++QL+ +E L+ KM ++L + G ++ + EE
Sbjct: 1540 SQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEE 1599
Query: 521 DNEDLKC---QLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGEAG 577
+++L+ Q+ ++ + ++ +++ + D+E ++++ + L L +
Sbjct: 1600 RSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLER---- 1655
Query: 578 GPPSTREAELKLRLRLVE--EEANILGRKIVELEVENRGLKAELDDLRGDDFNGSANPLM 635
R+ EL L+ ++ E+ KI+E ++E +K L + RG + + LM
Sbjct: 1656 -----RDQELMLQKERIQVLEDQRTRQTKILEEDLEQ--IKLSLRE-RGRELT-TQRQLM 1706
Query: 636 REQSE-----------SLSELRQHLQLVEDETELLRRNVADLEEQNKRITAELNKYKYKS 684
+E++E SL ++ L+ E E E + ++ +L+E ++ +L K
Sbjct: 1707 QERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKV 1766
Query: 685 GGHDSARHHDNAKTEALQEELKAARLQINELSGKVMQLQYE 725
G + LQ++L+ AR Q EL + +Q Q +
Sbjct: 1767 GETSLLLSQREQEIVVLQQQLQEAREQ-GELKEQSLQSQLD 1806
Score = 63.2 bits (152), Expect = 1e-09
Identities = 85/429 (19%), Positives = 178/429 (41%), Gaps = 59/429 (13%)
Query: 330 GMQAAAPPSSQPHPQQLQEQEEMQEEMEKLREENETLKNEIDELRTEMD----------- 378
G Q A Q H Q +E + +++ ++KL E +TL + +L+ E+D
Sbjct: 411 GCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQK 470
Query: 379 ---EMRDTF--FEEDACQLQEMRHELE------RANKNCRILQYRLRKAERKRLRYAQTG 427
E+R E++A +L+ + EL+ + K + + L ER+RL+ G
Sbjct: 471 AREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMG 530
Query: 428 EIDGELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTTEDENEKLRQQLIEVEIAKQALQ 487
++ + SL +L ++ H E E + +++T + Q + E+ ++ L+
Sbjct: 531 -LEAKQSESL-SELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLK 588
Query: 488 NELEKMKELSLKRRGSKD---LPKSEKKAQQTPTEEDNEDLKCQLQFVKEEAALMRKKMA 544
E+ ++ ++K + L K Q EE+N+ + +++ ++ ++ +A
Sbjct: 589 TEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLA 648
Query: 545 KIDKEKDRFEHELQKYRSFYGDLDSPLPKGEAGGPPSTREAELKLRLRLVEEEANILGRK 604
+ +K ++ + L++ L K E G AEL+ LR ++EE + +K
Sbjct: 649 EAEKRREALWEK-------NTHLEAQLQKAEEAG------AELQADLRDIQEEKEEIQKK 695
Query: 605 IVELEVENRGLKAELDDL-----RGDDFNGSA----NPLMREQS----------ESLSEL 645
+ E + +L+ L R ++ A L+RE++ +L
Sbjct: 696 LSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDL 755
Query: 646 RQHLQLVEDETELLRRNVADLEEQNKRITAELNKYKYKSGGHDSARHHDNAKTEALQEEL 705
+ LQ + ELL ++ + ++QN I + + + A+ + L+ EL
Sbjct: 756 AEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLEL 815
Query: 706 KAARLQINE 714
R Q +
Sbjct: 816 DTERSQAEQ 824
Score = 63.2 bits (152), Expect = 1e-09
Identities = 87/411 (21%), Positives = 174/411 (42%), Gaps = 56/411 (13%)
Query: 343 PQQLQEQEE----MQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRH- 397
P +QE+E+ +E++ +L ++ ET +N ++ E+ E +D E Q+Q+++
Sbjct: 1493 PMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLEL-EKKDQMIESQRGQVQDLKKQ 1551
Query: 398 ---------ELERANKNCRILQYRLRKAE--RKRLRYAQTGEIDGELLRSLEQDLKVAKD 446
ELE + Q +++ E R+ R A T L LE+ + +
Sbjct: 1552 LVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALT-----HLTLDLEERSQELQA 1606
Query: 447 VSVRLHHELEN----VEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRG 502
S ++H +LE+ + + + E + R+Q+ E++ K+ L +LE+ + + ++
Sbjct: 1607 QSSQIH-DLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKE 1665
Query: 503 SKDLPKSEKKAQQTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRS 562
+ + ++ Q EED E +K L+ E R+ M ++R E ++
Sbjct: 1666 RIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLM------QERAEEGKGPSKA 1719
Query: 563 FYGDLDSPLPKGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDL 622
G L+ +KL LR E+E I EL+ L+ +L L
Sbjct: 1720 QRGSLE-----------------HMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGL 1762
Query: 623 RGDDFNGSANPLMREQSESLSELRQHLQLVEDETELLRRNVADLEEQNKRITA----ELN 678
G + L+ ++ + + L+Q LQ ++ EL +++ ++ +R A EL
Sbjct: 1763 HRK--VGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELE 1820
Query: 679 KYKYKSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVMQLQYENRVL 729
+ + K +ALQ L+ A + + E G++ + + R L
Sbjct: 1821 ALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRL 1871
Score = 62.8 bits (151), Expect = 1e-09
Identities = 94/467 (20%), Positives = 184/467 (39%), Gaps = 45/467 (9%)
Query: 255 LQSELIQFHLKKERAAAAAAAAQMHAKNGGGSSSRSSPVSGPPAVCETLAV---ASASPM 311
L+ EL++ + E AA A A Q A+ ++ + V+ A L+ A A
Sbjct: 554 LEGELLRQE-QTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDK 612
Query: 312 AAAAEGPQQSAEGSASGGGMQAAAPPSSQPHPQQLQEQEEMQEEMEKLREENETLKNEID 371
+ Q E + S AA + L E E+ +E + + E + +
Sbjct: 613 VGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAE 672
Query: 372 ELRTEMD-EMRDTFFEEDACQ--LQEMRHELERANKNCRILQYRLRKAERKRLRYAQTGE 428
E E+ ++RD E++ Q L E RH+ E A L ++ E R Q E
Sbjct: 673 EAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKE 732
Query: 429 IDGELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTTEDENEKLRQQLIEVEIAKQALQN 488
+LE L+ + L +L+ + + E + +QQ +E+ K L+
Sbjct: 733 ALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEV 792
Query: 489 ELEKMKELSLKRRGSKDLPKSEKKAQQTPTEEDNEDLKCQL-QFVKEEAALMRKKMAKID 547
+++ + + +G K E +++ E++ + QL Q +E + ++ A +
Sbjct: 793 QIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHE 852
Query: 548 KEKDRFEHELQKYRSFYGDLDSPLPKGEAGGPPSTREAELKLRLRLVEEEANILGRKIVE 607
KE ++ + +K RS++ + EL L +E E L ++ E
Sbjct: 853 KEVNQLREKWEKERSWH-------------------QQELAKALESLEREKMELEMRLKE 893
Query: 608 LEVENRGLKAELDDLRGDDFNGSANPLMREQSESLSELRQHLQLVEDETELLRRNVADLE 667
+ E ++A+ ++ R + + + E +S L LQ ++ +AD
Sbjct: 894 QQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQ--------TQKELADAS 945
Query: 668 EQNKRITAELNKYKYKSGGHDSARHHDNAKTEALQEELKAARLQINE 714
+Q +R+ ++ K K + T LQ +L+ A+ ++ E
Sbjct: 946 QQLERLRQDMKVQKLK----------EQETTGILQTQLQEAQRELKE 982
Score = 57.8 bits (138), Expect = 5e-08
Identities = 88/446 (19%), Positives = 191/446 (42%), Gaps = 68/446 (15%)
Query: 350 EEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERANKNCRIL 409
+E +E+E LR E+++ +++ + R + +++ + A + +H LE+A
Sbjct: 1936 KERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQA------- 1988
Query: 410 QYRLRKAERKRLRYAQTGEIDGEL------LRSLEQDLKVAK----DVSVRLHHELENVE 459
E R A T + L R LE+ L++ + D +R +++ ++
Sbjct: 1989 -------ELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQ 2041
Query: 460 EKRTTTEDE--NEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGS--KDLPKSEKKAQQ 515
+ ++E +++ R+QL+E +A++ +N +++ + L +R + L +S ++ Q
Sbjct: 2042 QALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQL 2101
Query: 516 TPTEEDNEDLKCQ-------LQFV--KEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGD 566
T +++ E L+ + L+ + + + M ++ K+D + R + EL++ ++
Sbjct: 2102 TLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQ 2161
Query: 567 LDS-PLPKGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDLRGD 625
++ + E + A+ K + ++E A L ++E + E + L+ EL+ R
Sbjct: 2162 TEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTR-- 2219
Query: 626 DFNGSANPLMREQSESLSELRQHLQLVEDETELLRRNVADLEEQNKRITAELNKYKYKSG 685
+L + R H EL R EQ ++ E++ + +
Sbjct: 2220 --------------RALEKERLHSPGATSTAELGSRG-----EQGVQL-GEVSGVEAEPS 2259
Query: 686 GHDSARHHDNAKTEALQE-----ELKAARLQIN--ELSGKVMQLQYENRVLMSNMQRYDL 738
+ + E LQ+ E+ +RLQ + +L + Q++ E R L R
Sbjct: 2260 PDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQ 2319
Query: 739 ASHLGIRGSPRDSDAESDA-GKKESD 763
A L I + S + D G+K SD
Sbjct: 2320 AGSLEISKATASSPTQQDGRGQKNSD 2345
Score = 57.0 bits (136), Expect = 8e-08
Identities = 87/408 (21%), Positives = 174/408 (42%), Gaps = 51/408 (12%)
Query: 344 QQLQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERAN 403
++ QE + ++ L + L E+ E E+ R+ EE Q + + +LER +
Sbjct: 1599 ERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQI-EELQRQKEHLTQDLERRD 1657
Query: 404 KNCRILQYRLRKAERKRLRYAQTGEIDGELLRS---------------LEQDLKVAKDVS 448
+ + + R++ E +R R + E D E ++ +++ + K S
Sbjct: 1658 QELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPS 1717
Query: 449 VRLHHELENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELE----KMKELSLK-RRGS 503
LE+++ E E E ++ + E++ K L+ +L+ K+ E SL +
Sbjct: 1718 KAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQRE 1777
Query: 504 KDLPKSEKKAQQTPTEEDNEDLKCQLQFVKEEAALMRK--KMAKIDKEKDRFEHELQKYR 561
+++ +++ Q+ + + ++ Q Q + + AL ++ ++ + +E+ + + + ++ +
Sbjct: 1778 QEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVK 1837
Query: 562 SFYGDLDSPLPKGEAGGPPSTREAEL---KLRLRLVEEEANILGRKIVELEVENRGLKAE 618
L L +A R EL K + R +EEE + GR++ + L+
Sbjct: 1838 EKADALQGALE--QAHMTLKERHGELQDHKEQARRLEEELAVEGRRV-------QALEEV 1888
Query: 619 LDDLRGDDFNGSANPLMREQSESLSELRQHLQLVEDETELLRRNVADLEEQNKRITAELN 678
L DLR + REQ ++L L+Q E E+ R + D Q + + E +
Sbjct: 1889 LGDLRAES---------REQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERD 1939
Query: 679 -KYKYKSGGHDSARHHD---NAKTEALQEELKAARLQINELSGKVMQL 722
+ + S+RH + A+ EALQE L A L GK L
Sbjct: 1940 QELEALRAESQSSRHQEEAARARAEALQEALGKAHA---ALQGKEQHL 1984
Score = 53.1 bits (126), Expect = 1e-06
Identities = 84/395 (21%), Positives = 167/395 (42%), Gaps = 31/395 (7%)
Query: 344 QQLQEQEEMQEEMEKLREENET-LKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERA 402
Q QE++ ++ + +E +T L+ + E++++R+ + +E + QE+ LE
Sbjct: 821 QAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESL 880
Query: 403 NKNCRILQYRLRKAERK-RLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEEK 461
+ L+ RL++ + + AQ E + +L Q + V L L +++
Sbjct: 881 EREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKE 940
Query: 462 RTTTEDENEKLRQQLIEVEIAKQA----LQNEL-EKMKELSLKRRGSKDLPKSEKKAQQT 516
+ E+LRQ + ++ +Q LQ +L E +EL R +D + + + +
Sbjct: 941 LADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRD-DLAALQEESS 999
Query: 517 PTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGEA 576
+D DL+ Q++ +K + +++E E Q+Y +L+ + +A
Sbjct: 1000 SLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELE----REKA 1055
Query: 577 GGPPSTREAELKLRL-----RLVEEEANILGRKIVELEVENRGLKAELDDLRGD------ 625
S E E +L + + ++E + L + + E + E + L A+++ LR +
Sbjct: 1056 SLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEA 1115
Query: 626 DFNGSANPLMREQSES---LSELRQHLQLVEDETELLRRNVADLEEQNKRITAELNKYKY 682
DF L+ E S +LR L E + L+ + E Q + + AE
Sbjct: 1116 DFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAE-----Q 1170
Query: 683 KSGGHDSARHHDNAKTEALQEELKAARLQINELSG 717
+ G A+ + ALQ+ L + ELSG
Sbjct: 1171 QPGNQAQAQAQLASLYSALQQALGSVCESRPELSG 1205
Score = 52.0 bits (123), Expect = 3e-06
Identities = 80/388 (20%), Positives = 158/388 (40%), Gaps = 56/388 (14%)
Query: 346 LQEQEEM-QEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQL------------ 392
LQE + + Q+E+ LR++ + + E EL +M+ +R E++A L
Sbjct: 1071 LQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEA 1130
Query: 393 -----QEMRHELERANKNCRILQYRLRK---------AERKRLRYAQTGEIDGELLRSLE 438
Q++R L LQ RLR AE++ AQ L +L+
Sbjct: 1131 SHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQ 1190
Query: 439 QDLKVAKDVSVRLHHELENVEEKRTTTEDEN---EKLRQQLIEVEIAKQALQNELEKMKE 495
Q L + L ++ D+N ++ + ++ +A+ + L K+ +
Sbjct: 1191 QALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQ 1250
Query: 496 LSLKRRGSKDLPKSEKKAQQ---TPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDR 552
K + ++D+ + + + + T TE + + +LQ ++ + + +++ +K + +++
Sbjct: 1251 DLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNS 1310
Query: 553 FEHELQKYRSFYGDLDSPLPKGEAGGPPSTREAEL-------------KLRLRLVEEEAN 599
E EL + L S L + E + E EL L+ +VE A
Sbjct: 1311 LESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQ 1370
Query: 600 ILGRKIVE---------LEVENRGLKAELDDLRGDDFNGSANPLM-REQSESLSELRQHL 649
I+E L+++N +++E + + G + E+L+ L Q L
Sbjct: 1371 ASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTL 1430
Query: 650 QLVEDETELLRRNVADLEEQNKRITAEL 677
E+E E LR + +LE+Q + A L
Sbjct: 1431 AEREEEVETLRGQIQELEKQREMQKAAL 1458
Score = 52.0 bits (123), Expect = 3e-06
Identities = 90/424 (21%), Positives = 173/424 (40%), Gaps = 58/424 (13%)
Query: 339 SQPHP--QQLQEQ-EEMQEEMEKLREENETLKNEIDELRTEMDEMRDTF--FEEDACQLQ 393
SQ H Q LQ Q + QEE K + +L++E+ EL M ++ E + Q
Sbjct: 1281 SQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQ 1340
Query: 394 EMRHELERANKNCR---------------------ILQYRLRKAERKRLRYAQTGEIDGE 432
R L+ A +N IL+ LR A + E + E
Sbjct: 1341 GERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERE 1400
Query: 433 LLRSLEQ--DLKVAKDVSVRLHHELENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNEL 490
++L++ +LKVA+ + L L + + E+E E LR Q+ E+E ++ + L
Sbjct: 1401 RAQALQEQGELKVAQGKA--LQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAAL 1458
Query: 491 EKMKELSLKRRGSKDLPKSEKKAQQTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEK 550
E + L LK+R + + E+ + E L +Q +++ + R+++ +++K++
Sbjct: 1459 E-LLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDR 1517
Query: 551 DR----FEHELQKYRSFYGDLDSPLPKGEAGGPPSTREAELKLRLRLVEEEAN-----IL 601
+ EH+L + + + + + G ++ + L +E E N
Sbjct: 1518 ETQRNVLEHQLLEL-----EKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQ 1572
Query: 602 GRKIVELEVENRGLKAELDDLRGDDFNGSANPLMREQSESLSELRQH-------LQLVED 654
+ I ELE + + L L D S ++ QS + +L H LQ +
Sbjct: 1573 QKLIKELEGQRETQRVALTHLTLDLEERSQE--LQAQSSQIHDLESHSTVLARELQERDQ 1630
Query: 655 ETELLRRNVADLEEQNKRITAELNK----YKYKSGGHDSARHHDNAKTEALQEELKAARL 710
E + R + +L+ Q + +T +L + + +T+ L+E+L+ +L
Sbjct: 1631 EVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKL 1690
Query: 711 QINE 714
+ E
Sbjct: 1691 SLRE 1694
Score = 48.1 bits (113), Expect = 4e-05
Identities = 101/511 (19%), Positives = 200/511 (39%), Gaps = 61/511 (11%)
Query: 251 KEGCLQSELIQFHLKKERAAAAAAAAQMHAKNGGGSSSRSSPVSGPPAVCETLAVASASP 310
KE + E IQ ++ER A +A QM + R S + + LA AS
Sbjct: 892 KEQQTEMEAIQAQREEERTQAESALCQMQLET---EKERVSLLETLLQTQKELADASQQL 948
Query: 311 MAAAAEGPQQSAEGSASGGGMQAAAPPSSQPHPQQLQEQ-EEMQEEMEKLREENETLKNE 369
+ Q + + G +Q Q ++L+E + ++++ L+EE+ +L +
Sbjct: 949 ERLRQDMKVQKLKEQETTGILQTQL----QEAQRELKEAARQHRDDLAALQEESSSLLQD 1004
Query: 370 IDELRTEMDEMRDTFFEEDACQL---QEMRHELERANKNCRI----------LQYRLRKA 416
+L+ ++++++ +D Q QE++ +L + RI L L +
Sbjct: 1005 KMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEK 1064
Query: 417 ERKRLRYAQTGEIDGELLRSLEQDLKVA----KDVSVRLHHELENVEEKRTTTEDENEKL 472
E++ L + I + L +L QD++ A K++S ++ + V+EK + +L
Sbjct: 1065 EQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQL 1124
Query: 473 RQQLIEVEIAKQALQNEL----EKMKELSLKRRGSKDLPKSEKKAQQTPTEEDNEDLKCQ 528
++L I +Q L+ L K +L L+ R + +S+ +A + N+ + Q
Sbjct: 1125 LEELEASHITEQQLRASLWAQEAKAAQLQLRLRST----ESQLEALAAEQQPGNQ-AQAQ 1179
Query: 529 LQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGEAGGPPSTREAELK 588
Q +AL ++ + + + + S +G L + G + L
Sbjct: 1180 AQLASLYSAL-QQALGSVCESRPELSGGGDSAPSVWG-----LEPDQNGARSLFKRGPL- 1232
Query: 589 LRLRLVEEEANILGRKIVELEVENRGLKAELDDLRGDDFNGSANPLMREQSESLSELRQH 648
L A + + +L + + D LR + + +L +
Sbjct: 1233 ----LTALSAEAVASALHKLHQDLWKTQQTRDVLR----------------DQVQKLEER 1272
Query: 649 LQLVEDETELLRRNVADLEEQNKRITAELNKYKYKSGGHDSARHHDNAKTEALQEELKAA 708
L E E + + DL+ Q + E +K++ K +S + +LQ L+ A
Sbjct: 1273 LTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRA 1332
Query: 709 RLQINELSGKVMQLQYENRVLMSNMQRYDLA 739
LQ E G+ LQ L + ++ A
Sbjct: 1333 ELQRMEAQGERELLQAAKENLTAQVEHLQAA 1363
Score = 47.8 bits (112), Expect = 5e-05
Identities = 90/439 (20%), Positives = 177/439 (40%), Gaps = 70/439 (15%)
Query: 344 QQLQEQEEMQEEMEKLREENE----TLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHEL 399
Q+ QE +Q+++++ RE+ E +L++++DE + + + RD E + Q+ + +
Sbjct: 1775 QREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQ-RDQELEALQQEQQQAQGQE 1833
Query: 400 ERANKNCRILQYRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVE 459
ER + LQ L +A L+ +L+ K+ + RL EL
Sbjct: 1834 ERVKEKADALQGALEQAHM--------------TLKERHGELQDHKEQARRLEEELAVEG 1879
Query: 460 EKRTTTEDENEKLRQQLIEVEIAKQALQNE-LEKMKELSLKRRGSKDLPKSEKKAQQTPT 518
+ E+ LR + E E A ALQ + E+ +E ++ R +D S +AQ
Sbjct: 1880 RRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQD---SWLQAQAVLK 1936
Query: 519 EEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQK-YRSFYGDLDSPLPKGEAG 577
E D E L+ ++ E+ R + + + L K + + G L + E
Sbjct: 1937 ERDQE-----LEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELS 1991
Query: 578 GPPSTREAELKLRLRLVEEEANIL--GRKIVELEVENRGLKAELDDLRGDDFNGSANPLM 635
A L+ L + + L +I E E++++ L+ + D +
Sbjct: 1992 RSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQED--------------V 2037
Query: 636 REQSESLSELRQHLQLVEDETELLRRNVADLEEQNKRITAELNKYKYKSGGHDSARHHDN 695
++ ++L++ + L+ ++ +LL +++A ++N + N
Sbjct: 2038 QQLQQALAQRDEELRHQQEREQLLEKSLAQRVQEN------------------MIQEKQN 2079
Query: 696 AKTEALQEELKAARLQINELSGKVMQLQYENRVLMSNMQRYDLASHLGIRGSPRDSDAES 755
E +EE++ + EL + Q + E L QR +L + + S + S E
Sbjct: 2080 LGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEA---LPHSHKTSPMEE 2136
Query: 756 DAGKKESDDDSRPPHRKRE 774
+ K DS P +RE
Sbjct: 2137 QSLKL----DSLEPRLQRE 2151
Score = 47.4 bits (111), Expect = 6e-05
Identities = 71/345 (20%), Positives = 143/345 (41%), Gaps = 54/345 (15%)
Query: 417 ERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTTEDENEKLRQQL 476
+R L A + E L L QDL + L +++ +EE+ T TE E ++ +L
Sbjct: 1228 KRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTEL 1287
Query: 477 IEVEIAKQALQNELEKMK----------EL--------SLKRRGSK-DLPKSEKKAQQTP 517
+++ +Q QN+ EK K EL SL+ R + +L + E + ++
Sbjct: 1288 QDLQ--RQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGEREL 1345
Query: 518 TEEDNEDLKCQLQFVK----------------EEAALMRKKMAKIDKEKDRFEHELQKYR 561
+ E+L Q++ ++ EE + K+ E+ E E +
Sbjct: 1346 LQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQAL 1405
Query: 562 SFYGDLDSPLPKGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDD 621
G+L K G A L L EEE L +I ELE + KA L+
Sbjct: 1406 QEQGEL-----KVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALEL 1460
Query: 622 LRGDDFNGSANPLMREQSESLSELRQHLQLVEDETELLRRNVADLEEQNKRITAELNKYK 681
L D ++++++ + ++ +Q +E +L ++E+ +++T + + +
Sbjct: 1461 LSLD---------LKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIR 1511
Query: 682 YKSGGHDSARH---HDNAKTEALQEELKAARLQINELSGKVMQLQ 723
++ R+ H + E + +++ R Q+ +L +++ L+
Sbjct: 1512 ELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLE 1556
Score = 40.0 bits (92), Expect = 0.010
Identities = 103/567 (18%), Positives = 219/567 (38%), Gaps = 65/567 (11%)
Query: 351 EMQEEMEKLREENETLKNEIDELRTEMDEMRDTFF-EEDACQLQEMRHELERANKNCRIL 409
+++ MEK N+ L+ ++++L + RD +E Q+++ + ++ R+L
Sbjct: 119 QLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLL 178
Query: 410 QYRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDV---SVRLHHELENVEEKRTTTE 466
+R D +L+ + ++++ + +RL ++ E +
Sbjct: 179 SLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRM 238
Query: 467 DENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKK-------AQQTPTE 519
D E QL+ + Q L+ E + + ++ + DL K+E + A T ++
Sbjct: 239 DGREPA--QLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQ 296
Query: 520 EDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGEAGGP 579
+ NED + ++ ++E ++ ++ EHE + L +
Sbjct: 297 KQNEDYEKMIKALRETVEILETNHTEL------MEHE------------ASLSRNAQEEK 338
Query: 580 PSTREAELKLRLRLVEEEANILGRKIVELEVE-NRGLKAELDDLRGDDFNGSANPLMREQ 638
S ++ + +VEE NI E +E + + ++ D D ++ +
Sbjct: 339 LSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRR 398
Query: 639 SESLSELRQHLQLVEDETELLRRNVADLEEQNKRITAELNKYKYKSGGHDSARHHDNAKT 698
+++ +LRQ L ++ LL++ EE+ K + L K +G D+ +T
Sbjct: 399 RQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKL---TGERDTLA----GQT 451
Query: 699 EALQEELKAARLQINELSGKVMQLQYENRVLMSNMQRYDLAS-HLGIRGSPRDSDAESDA 757
LQ E+ + + L +L+ + VL R + L ++G +S
Sbjct: 452 VDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQG-------DSAQ 504
Query: 758 GKKESDDDS-----RPPHRKREGPIGGES-DSEEVRNIRCLTPTRSFYPAPGPWPKSFSD 811
G+KE + R R +E +G E+ SE + + L G
Sbjct: 505 GQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELL----- 559
Query: 812 RQQMKDIRSEAERLGKTIDRLIADTSTIITEARIYVANGDLFGLMDEEDDGSRIREHELL 871
RQ+ ++ + R ++I L + +T+ TE A ++E ++
Sbjct: 560 RQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKV------ 613
Query: 872 YRINAQMKAFRKELQTFIDRLEVPKSA 898
+N Q+ +E Q+ R+E + A
Sbjct: 614 -GLNQQLLQLEEENQSVCSRMEAAEQA 639
Score = 37.0 bits (84), Expect = 0.087
Identities = 53/265 (20%), Positives = 108/265 (40%), Gaps = 35/265 (13%)
Query: 334 AAPPSSQPHPQQLQE------QEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEE 387
A P S + P + Q + +Q E+E+L+ + E R + ++ + +
Sbjct: 2124 ALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQT 2183
Query: 388 DAC--QLQEMR-----HELERANKNCRI---LQYRLRKAERKRLRYAQTGEIDGELLRSL 437
A LQE+ LER ++ R+ L+ R E++RL ++ EL
Sbjct: 2184 KASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERL-HSPGATSTAELGSRG 2242
Query: 438 EQDLKVAKDVSVRLH------------HELENVEEKRTTTEDENEKLRQQLIEVEIAKQA 485
EQ +++ + V LE++++ E + +L++ +++ +
Sbjct: 2243 EQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQ 2302
Query: 486 LQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTEED-----NEDLKCQLQFVKEEAALMR 540
++ E K+K +++ + L S+ A +PT++D N D KC + KE L
Sbjct: 2303 VERERRKLKREAMRAAQAGSLEISKATAS-SPTQQDGRGQKNSDAKCVAELQKEVVLLQA 2361
Query: 541 KKMAKIDKEKDRFEHELQKYRSFYG 565
+ + +++D Q R G
Sbjct: 2362 QLTLERKQKQDYITRSAQTSRELAG 2386
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 71.6 bits (174), Expect = 3e-12
Identities = 111/553 (20%), Positives = 229/553 (41%), Gaps = 84/553 (15%)
Query: 346 LQEQEEMQEEMEKLREENETLKNEI---DELRTEMDEMRDTFFEED---ACQLQEMRHEL 399
L + E ++EM ++EE + K+E+ + R E++E T +E Q+Q L
Sbjct: 842 LLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSL 901
Query: 400 ERANKNCRILQYRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVE 459
A + C L + E K ++ + + + ++++ L + +E
Sbjct: 902 ADAEERCEQLIKNKIQLEAK--------------IKEVTERAEEEEEINAELTAKKRKLE 947
Query: 460 EKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTE 519
++ + + + + L L +VE K A +N+++ + E + EKKA Q +
Sbjct: 948 DECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQ 1007
Query: 520 EDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGEAGGP 579
+ +DL+ + +++ ++ K K++++ D E L++ + DL+ K E G
Sbjct: 1008 QTLDDLQAE----EDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLE-GDL 1062
Query: 580 PSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDLRGDDFNGSANPLMREQS 639
+E+ + + E + L K+ + E E L ++++D + + +
Sbjct: 1063 KLAQESTMDM-----ENDKQQLDEKLEKKEFEISNLISKIEDEQAVEI---------QLQ 1108
Query: 640 ESLSELRQHLQLVEDETELLRRNVADLEEQNKRITAELNKYKYK---SGGHDSARHHDNA 696
+ + EL+ ++ + +E E R + A E+Q ++ EL + + +GG SA+ N
Sbjct: 1109 KKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNK 1168
Query: 697 KTEALQEELKAARLQINELSGKVMQLQYENRVLMSNMQRYDLASHLG-----IRGSPRDS 751
K EA E + R + E + LQ+E V + D + LG ++ +
Sbjct: 1169 KREA---EFQKLRRDLEEAT-----LQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKL 1220
Query: 752 DAESDAGKKESDDDSRPPHRKREGPIGGESDSEEVRNIRCLTPTRSFYPAPGPWPKSFSD 811
+ E K E+DD S E+ S+ N+ + +S D
Sbjct: 1221 EKEKSELKMETDDLSS----------NAEAISKAKGNLEKMC-------------RSLED 1257
Query: 812 RQQMKDIRSEAERLGKTIDRLIADTSTIITEARIYVANGD----LFGLMDEEDDGSRIRE 867
Q+ +++++ E + I+ L A + + TEA Y D L + S +
Sbjct: 1258 --QVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQI 1315
Query: 868 HELLYRINAQMKA 880
EL +++ + KA
Sbjct: 1316 EELKHQLEEETKA 1328
Score = 63.2 bits (152), Expect = 1e-09
Identities = 90/387 (23%), Positives = 176/387 (45%), Gaps = 49/387 (12%)
Query: 351 EMQEEMEKLREEN----ETLKNEID-ELRTEMDEMRDTFFEEDACQLQEMRHELERANKN 405
E EE+++L+ + ET+++ +D E+R+ D +R E L EM +L AN
Sbjct: 1581 EKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEG--DLNEMEIQLNHAN-- 1636
Query: 406 CRILQYRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTT 465
R A Y T I E L+ L+ +D L +L VE +
Sbjct: 1637 --------RLAAESLRNYRNTQGILKETQLHLDDALRGQED----LKEQLAIVERRANLL 1684
Query: 466 EDENEKLRQQLIEVEIAKQALQNEL-EKMKELSLKRRGSKDLPKSEKKAQQTPTEEDNED 524
+ E E+L L + E +++ + EL + + + L + L ++KK E D
Sbjct: 1685 QAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKL-----ENDVSQ 1739
Query: 525 LKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGEAGGPPSTRE 584
L+ +++ V +E+ +K K + EL+K + D + L + + + ++
Sbjct: 1740 LQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQ----DTSAHLERMKKNLEQTVKD 1795
Query: 585 AELKLRLRLVEEEANILGRK-IVELEVENRGLKAELDDLRGDDFNGSANPLMREQSESLS 643
L+ RL E+ A G+K I +LE R L+ E+++ + + +E++
Sbjct: 1796 --LQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQ------------KRNAEAVK 1841
Query: 644 ELRQHLQLVED---ETELLRRNVADLEEQNKRITAELNKYKYKSGGHDSARHHDNAKTEA 700
LR+H + V++ +TE R+NV L++ ++ A++ YK ++ + + + +K
Sbjct: 1842 GLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRK 1901
Query: 701 LQEELKAARLQINELSGKVMQLQYENR 727
LQ EL+ A + + +V +L+ ++R
Sbjct: 1902 LQHELEEAEERADIAESQVNKLRVKSR 1928
Score = 62.4 bits (150), Expect = 2e-09
Identities = 133/639 (20%), Positives = 260/639 (40%), Gaps = 97/639 (15%)
Query: 348 EQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEE-------DACQLQEMRHELE 400
++EE Q + L + L+ E E ++DE +D + Q++E++H+LE
Sbjct: 1265 KEEEQQRLINDLTAQRARLQTEAGEYSRQLDE-KDALVSQLSRSKQASTQQIEELKHQLE 1323
Query: 401 RANKNCRILQYRLRKAERK----RLRYAQTGEIDGELLRSLEQ-DLKVA------KDVSV 449
K L + L+ + R +Y + E EL R+L + + +VA + ++
Sbjct: 1324 EETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAI 1383
Query: 450 RLHHELENVEEKRT----TTEDENEKLRQQLIEVEIAKQALQNELEK-MKELSLKRRGSK 504
+ ELE ++K E+ E + + +E KQ LQNE+E M ++
Sbjct: 1384 QRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACA 1443
Query: 505 DLPKSEKKAQQTPTE--EDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRS 562
L K ++ + +E + E+ + +L+ ++E+ + ++ K+ + +L+ R
Sbjct: 1444 ALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRR 1503
Query: 563 FYGDLD---SPLPKGEAGGPPSTREAELKLRLRLVEEEANI-LGRKIVELEVENRGLKAE 618
+L S L + A G E E K++ ++ +E+ I + E +E+ K
Sbjct: 1504 ENKNLQQEISDLTEQIAEGGKQIHELE-KIKKQVEQEKCEIQAALEEAEASLEHEEGKIL 1562
Query: 619 LDDLRGDDFNGSANPLMREQSESLSEL-RQHLQLVED-----ETELLRRNVA-------- 664
L + + + E+ E + +L R H ++VE + E+ RN A
Sbjct: 1563 RIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKME 1622
Query: 665 -DLEEQN------KRITAE-LNKYKYKSG-GHDSARHHDNA--KTEALQEELKAARLQIN 713
DL E R+ AE L Y+ G ++ H D+A E L+E+L + N
Sbjct: 1623 GDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRAN 1682
Query: 714 ELSGKVMQL-----QYENRVLMSNMQRYDLASHLGIRGSPRDSDAESDAGKKESDDDSRP 768
L ++ +L Q E ++ + D + + + + S + KK+ ++D
Sbjct: 1683 LLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINT---KKKLENDVSQ 1739
Query: 769 PHRKREGPIGGESDSEEVRNIRCLTPTRSFYPAPGPWPKSFSDRQQMKDIRSEAERLGKT 828
+ E I ES + E + + +T + ++ +D + ER+ K
Sbjct: 1740 LQSEVEEVI-QESRNAEEKAKKAITDAAMM----------AEELKKEQDTSAHLERMKKN 1788
Query: 829 IDRLIADTSTIITEARIYVANG-------------DLFGLMDEEDDGSR-----IREHE- 869
+++ + D + EA G +L G ++ E + +R+HE
Sbjct: 1789 LEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHER 1848
Query: 870 LLYRINAQMKAFRK---ELQTFIDRLEVPKSADDRGAEE 905
+ + Q + RK LQ +D+L+ + R AEE
Sbjct: 1849 RVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEE 1887
Score = 42.0 bits (97), Expect = 0.003
Identities = 60/300 (20%), Positives = 124/300 (41%), Gaps = 55/300 (18%)
Query: 346 LQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERANKN 405
L+ QE+++E++ + L+ EI+EL ++ + ER+ K
Sbjct: 1664 LRGQEDLKEQLAIVERRANLLQAEIEELWATLE-------------------QTERSRKI 1704
Query: 406 CRILQYRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTT 465
Q L +ER +L + Q + + LE D+ + + E N EEK
Sbjct: 1705 AE--QELLDASERVQLLHTQNTSLI-NTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKA 1761
Query: 466 --------------EDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEK 511
+D + L + +E + LQ+ L++ ++L+LK G K + K E
Sbjct: 1762 ITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALK-GGKKQIQKLEA 1820
Query: 512 KAQQTPTEEDNED---------LKCQLQFVKE---EAALMRKKMAKIDKEKDRFEHELQK 559
+ ++ E +NE L+ + VKE + RK + ++ D+ + +++
Sbjct: 1821 RVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKS 1880
Query: 560 YRSFYGDLDSPLPKGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAEL 619
Y+ + + E ++ +L+ L EE A+I ++ +L V++R + ++
Sbjct: 1881 YKRQAEEAE------EQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKI 1934
Score = 35.8 bits (81), Expect = 0.19
Identities = 41/165 (24%), Positives = 72/165 (43%), Gaps = 33/165 (20%)
Query: 344 QQLQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQ-------EMR 396
++L+++++ +E++++ L+ + +L+ +DE + Q+Q E+
Sbjct: 1770 EELKKEQDTSAHLERMKKN---LEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELE 1826
Query: 397 HELERANKNCRILQYRLRKAER--KRLRYAQTGEIDGELLR-------------SLEQDL 441
E+E K LRK ER K L Y QT E +LR S ++
Sbjct: 1827 GEVENEQKRNAEAVKGLRKHERRVKELTY-QTEEDRKNVLRLQDLVDKLQAKVKSYKRQA 1885
Query: 442 KVAKDVSV-------RLHHELENVEEKRTTTEDENEKLRQQLIEV 479
+ A++ S +L HELE EE+ E + KLR + EV
Sbjct: 1886 EEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVKSREV 1930
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.129 0.358
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,502,730
Number of Sequences: 37866
Number of extensions: 2723996
Number of successful extensions: 60304
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 866
Number of HSP's successfully gapped in prelim test: 2646
Number of HSP's that attempted gapping in prelim test: 21969
Number of HSP's gapped (non-prelim): 20645
length of query: 947
length of database: 18,247,518
effective HSP length: 112
effective length of query: 835
effective length of database: 14,006,526
effective search space: 11695449210
effective search space used: 11695449210
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.