Search of human proteins with 5901990

Search of human proteins with 5901990

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|5901990 katanin p60 subunit A 1 [Homo sapiens]
         (491 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|5901990 katanin p60 subunit A 1 [Homo sapiens]                     979   0.0  
gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens]               638   0.0  
gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens]               638   0.0  
gi|226371754 katanin p60 subunit A-like 2 [Homo sapiens]              276   4e-74
gi|31742536 fidgetin-like 1 [Homo sapiens]                            253   2e-67
gi|112789543 fidgetin-like 1 [Homo sapiens]                           253   2e-67
gi|7019569 vacuolar protein sorting factor 4A [Homo sapiens]          248   7e-66
gi|11875211 spastin isoform 1 [Homo sapiens]                          246   3e-65
gi|40806170 spastin isoform 2 [Homo sapiens]                          244   1e-64
gi|17865802 vacuolar protein sorting factor 4B [Homo sapiens]         243   3e-64
gi|31377644 ATPase family, AAA domain containing 1 [Homo sapiens]     189   4e-48
gi|6005942 valosin-containing protein [Homo sapiens]                  187   1e-47
gi|64084766 fidgetin [Homo sapiens]                                   186   3e-47
gi|157671927 spermatogenesis associated 5 [Homo sapiens]              173   4e-43
gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens]            168   9e-42
gi|229577436 spermatogenesis associated 5-like 1 [Homo sapiens]       166   3e-41
gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]           163   4e-40
gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens]            161   1e-39
gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens]           159   4e-39
gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens]                 159   4e-39
gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens]                 159   4e-39
gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens]   157   2e-38
gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens]            155   8e-38
gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]     154   2e-37
gi|4506209 proteasome 26S ATPase subunit 2 [Homo sapiens]             147   2e-35
gi|4505725 peroxin1 [Homo sapiens]                                    147   2e-35
gi|21327685 YME1-like 1 isoform 1 [Homo sapiens]                      145   6e-35
gi|7657689 YME1-like 1 isoform 3 [Homo sapiens]                       145   6e-35
gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit ...   144   1e-34
gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo sapi...   144   1e-34

>gi|5901990 katanin p60 subunit A 1 [Homo sapiens]
          Length = 491

 Score =  979 bits (2531), Expect = 0.0
 Identities = 491/491 (100%), Positives = 491/491 (100%)

Query: 1   MSLLMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTYLQQKWQQVWQEIN 60
           MSLLMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTYLQQKWQQVWQEIN
Sbjct: 1   MSLLMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTYLQQKWQQVWQEIN 60

Query: 61  VEAKHVKDIMKTLESFKLDSTPLKAAQHDLPASEGEVWSMPVPVERRPSPGPRKRQSSQY 120
           VEAKHVKDIMKTLESFKLDSTPLKAAQHDLPASEGEVWSMPVPVERRPSPGPRKRQSSQY
Sbjct: 61  VEAKHVKDIMKTLESFKLDSTPLKAAQHDLPASEGEVWSMPVPVERRPSPGPRKRQSSQY 120

Query: 121 SDPKSHGNRPSTTVRVHRSSAQNVHNDRGKAVRCREKKEQNKGREEKNKSPAAVTEPETN 180
           SDPKSHGNRPSTTVRVHRSSAQNVHNDRGKAVRCREKKEQNKGREEKNKSPAAVTEPETN
Sbjct: 121 SDPKSHGNRPSTTVRVHRSSAQNVHNDRGKAVRCREKKEQNKGREEKNKSPAAVTEPETN 180

Query: 181 KFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRR 240
           KFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRR
Sbjct: 181 KFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRR 240

Query: 241 PWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFY 300
           PWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFY
Sbjct: 241 PWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFY 300

Query: 301 SPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATN 360
           SPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATN
Sbjct: 301 SPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATN 360

Query: 361 FPWDIDEALRRRLEKRIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGAD 420
           FPWDIDEALRRRLEKRIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGAD
Sbjct: 361 FPWDIDEALRRRLEKRIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGAD 420

Query: 421 ITNVCRDASLMAMRRRIEGLTPEEIRNLSKEEMHMPTTMEDFEMALKKVSKSVSAADIER 480
           ITNVCRDASLMAMRRRIEGLTPEEIRNLSKEEMHMPTTMEDFEMALKKVSKSVSAADIER
Sbjct: 421 ITNVCRDASLMAMRRRIEGLTPEEIRNLSKEEMHMPTTMEDFEMALKKVSKSVSAADIER 480

Query: 481 YEKWIFEFGSC 491
           YEKWIFEFGSC
Sbjct: 481 YEKWIFEFGSC 491


>gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens]
          Length = 490

 Score =  638 bits (1646), Expect = 0.0
 Identities = 331/495 (66%), Positives = 383/495 (77%), Gaps = 11/495 (2%)

Query: 1   MSLLMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTYLQQKWQQVWQEIN 60
           M+L  I +N K  REYALLGNYDS+MVYYQGV+ Q+ ++  SV+D  ++ KWQQV QE+ 
Sbjct: 1   MNLAEICDNAKKGREYALLGNYDSSMVYYQGVMQQIQRHCQSVRDPAIKGKWQQVRQELL 60

Query: 61  VEAKHVKDIMKTLESFKLDSTP-LKAAQHDLPASEGEVWSMPVPVERRPSPGPRK--RQS 117
            E + VK I+ TLESFK+D  P    +  D P  +  VW  PVP E R  P  R+  R+ 
Sbjct: 61  EEYEQVKSIVSTLESFKIDKPPDFPVSCQDEPFRDPAVWPPPVPAEHRAPPQIRRPNREV 120

Query: 118 SQYSDPKSHGNRPSTTVRVHRSSAQNVHNDRGKAVRCREKKEQNKGREEKNKSPA--AVT 175
                  +         R H  S         K    R+K  + +GR++K +       +
Sbjct: 121 RPLRKEMAGVGARGPVGRAHPISKSE------KPSTSRDKDYRARGRDDKGRKNMQDGAS 174

Query: 176 EPETNKFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFF 235
           + E  KFD  GYDKDLVEALERDI+S+NP++ WDDIADL EAKKLL+EAVVLPMWMP+FF
Sbjct: 175 DGEMPKFDGAGYDKDLVEALERDIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFF 234

Query: 236 KGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFE 295
           KGIRRPWKGVLMVGPPGTGKT+LAKAVATEC TTFFNVSSSTLTSKYRGESEKLVRLLFE
Sbjct: 235 KGIRRPWKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFE 294

Query: 296 MARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMV 355
           MARFY+P TIFIDEIDSICSRRGTS+EHEASRRVK+ELL+QMDGVGG  ENDDPSKMVMV
Sbjct: 295 MARFYAPTTIFIDEIDSICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMV 354

Query: 356 LAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEG 415
           LAATNFPWDIDEALRRRLEKRIYIPLP+AKGR ELL+I+LRE+EL  D+ L  IAE +EG
Sbjct: 355 LAATNFPWDIDEALRRRLEKRIYIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEG 414

Query: 416 YSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSKEEMHMPTTMEDFEMALKKVSKSVSA 475
           YSGADITNVCRDASLMAMRRRI GL+PEEIR LSKEE+ MP T  DFE+ALKK++KSVSA
Sbjct: 415 YSGADITNVCRDASLMAMRRRINGLSPEEIRALSKEELQMPVTKGDFELALKKIAKSVSA 474

Query: 476 ADIERYEKWIFEFGS 490
           AD+E+YEKW+ EFGS
Sbjct: 475 ADLEKYEKWMVEFGS 489


>gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens]
          Length = 490

 Score =  638 bits (1646), Expect = 0.0
 Identities = 331/495 (66%), Positives = 383/495 (77%), Gaps = 11/495 (2%)

Query: 1   MSLLMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTYLQQKWQQVWQEIN 60
           M+L  I +N K  REYALLGNYDS+MVYYQGV+ Q+ ++  SV+D  ++ KWQQV QE+ 
Sbjct: 1   MNLAEICDNAKKGREYALLGNYDSSMVYYQGVMQQIQRHCQSVRDPAIKGKWQQVRQELL 60

Query: 61  VEAKHVKDIMKTLESFKLDSTP-LKAAQHDLPASEGEVWSMPVPVERRPSPGPRK--RQS 117
            E + VK I+ TLESFK+D  P    +  D P  +  VW  PVP E R  P  R+  R+ 
Sbjct: 61  EEYEQVKSIVSTLESFKIDKPPDFPVSCQDEPFRDPAVWPPPVPAEHRAPPQIRRPNREV 120

Query: 118 SQYSDPKSHGNRPSTTVRVHRSSAQNVHNDRGKAVRCREKKEQNKGREEKNKSPA--AVT 175
                  +         R H  S         K    R+K  + +GR++K +       +
Sbjct: 121 RPLRKEMAGVGARGPVGRAHPISKSE------KPSTSRDKDYRARGRDDKGRKNMQDGAS 174

Query: 176 EPETNKFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFF 235
           + E  KFD  GYDKDLVEALERDI+S+NP++ WDDIADL EAKKLL+EAVVLPMWMP+FF
Sbjct: 175 DGEMPKFDGAGYDKDLVEALERDIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFF 234

Query: 236 KGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFE 295
           KGIRRPWKGVLMVGPPGTGKT+LAKAVATEC TTFFNVSSSTLTSKYRGESEKLVRLLFE
Sbjct: 235 KGIRRPWKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFE 294

Query: 296 MARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMV 355
           MARFY+P TIFIDEIDSICSRRGTS+EHEASRRVK+ELL+QMDGVGG  ENDDPSKMVMV
Sbjct: 295 MARFYAPTTIFIDEIDSICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMV 354

Query: 356 LAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEG 415
           LAATNFPWDIDEALRRRLEKRIYIPLP+AKGR ELL+I+LRE+EL  D+ L  IAE +EG
Sbjct: 355 LAATNFPWDIDEALRRRLEKRIYIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEG 414

Query: 416 YSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSKEEMHMPTTMEDFEMALKKVSKSVSA 475
           YSGADITNVCRDASLMAMRRRI GL+PEEIR LSKEE+ MP T  DFE+ALKK++KSVSA
Sbjct: 415 YSGADITNVCRDASLMAMRRRINGLSPEEIRALSKEELQMPVTKGDFELALKKIAKSVSA 474

Query: 476 ADIERYEKWIFEFGS 490
           AD+E+YEKW+ EFGS
Sbjct: 475 ADLEKYEKWMVEFGS 489


>gi|226371754 katanin p60 subunit A-like 2 [Homo sapiens]
          Length = 466

 Score =  276 bits (705), Expect = 4e-74
 Identities = 146/312 (46%), Positives = 214/312 (68%), Gaps = 18/312 (5%)

Query: 189 KDLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMV 248
           ++L   + RDI   NPN++W+DI  L  AK+L+KEAVV P+  P+ F GI  PWKG+L+ 
Sbjct: 162 RELAAVVSRDIYLHNPNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGILSPWKGLLLY 221

Query: 249 GPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFID 308
           GPPGTGKTLLAKAVATECKTTFFN+S+ST+ SK+RG+SEKLVR+LFE+AR+++P+TIF+D
Sbjct: 222 GPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLD 281

Query: 309 EIDSICSRRGTSE--EHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDID 366
           E++S+ S+RGT+   EHE S R+K ELLVQMDG+  + +      +V VLAA+N PW++D
Sbjct: 282 ELESVMSQRGTASGGEHEGSLRMKTELLVQMDGLARSED------LVFVLAASNLPWELD 335

Query: 367 EALRRRLEKRIYIPLPSAKGREELLRISL------RELELADDVDLASIAENMEGYSGAD 420
            A+ RRLEKRI + LPS + R+ ++   L      R LEL  +++ + +++  EGYSG+D
Sbjct: 336 CAMLRRLEKRILVDLPSREARQAMIYHWLPPVSKSRALELHTELEYSVLSQETEGYSGSD 395

Query: 421 ITNVCRDASLMAMRRRIEGLT--PEEIRNLSKEEMHMPTTMEDFEMALKKVSKSVSAADI 478
           I  VCR+A++  +R+  + L     E  +L + ++ + TT +  ++       + + A  
Sbjct: 396 IKLVCREAAMRPVRKIFDALENHQSESSDLPRIQLDIVTTADFLDVLTHTKPSAKNLA-- 453

Query: 479 ERYEKWIFEFGS 490
           +RY  W  EF S
Sbjct: 454 QRYSDWQREFES 465


>gi|31742536 fidgetin-like 1 [Homo sapiens]
          Length = 674

 Score =  253 bits (647), Expect = 2e-67
 Identities = 144/338 (42%), Positives = 205/338 (60%), Gaps = 24/338 (7%)

Query: 159 EQNKGREEK--NKSPAAVTEPETNKFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVE 216
           EQN G + K     P     P   +  +   +  ++E +  +I+   P V W+DIA +  
Sbjct: 351 EQNGGMQCKPYGAGPTEPAHPVDERLKNL--EPKMIELIMNEIMDHGPPVNWEDIAGVEF 408

Query: 217 AKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSS 276
           AK  +KE VV PM  P+ F G+R P KG+L+ GPPGTGKTL+ K +A++   TFF++S+S
Sbjct: 409 AKATIKEIVVWPMLRPDIFTGLRGPPKGILLFGPPGTGKTLIGKCIASQSGATFFSISAS 468

Query: 277 TLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQ 336
           +LTSK+ GE EK+VR LF +AR   PA IFIDEIDS+ S+RG   EHE+SRR+K E LVQ
Sbjct: 469 SLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLLSQRGDG-EHESSRRIKTEFLVQ 527

Query: 337 MDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREEL-LRISL 395
           +DG   +SE+      ++V+ ATN P +IDEA RRRL KR+YIPLP A  R+++ + +  
Sbjct: 528 LDGATTSSED-----RILVVGATNRPQEIDEAARRRLVKRLYIPLPEASARKQIVINLMS 582

Query: 396 RELELADDVDLASIAENMEGYSGADITNVCRDASLMAMR----RRIEGLTPEEIRNLSKE 451
           +E     + ++  I +  + +SGAD+T +CR+ASL  +R      I  +TP+++R     
Sbjct: 583 KEQCCLSEEEIEQIVQQSDAFSGADMTQLCREASLGPIRSLQTADIATITPDQVR----- 637

Query: 452 EMHMPTTMEDFEMALKKVSKSVSAADIERYEKWIFEFG 489
               P    DFE A + V  SVS  D+E YE W   FG
Sbjct: 638 ----PIAYIDFENAFRTVRPSVSPKDLELYENWNKTFG 671


>gi|112789543 fidgetin-like 1 [Homo sapiens]
          Length = 674

 Score =  253 bits (647), Expect = 2e-67
 Identities = 144/338 (42%), Positives = 205/338 (60%), Gaps = 24/338 (7%)

Query: 159 EQNKGREEK--NKSPAAVTEPETNKFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVE 216
           EQN G + K     P     P   +  +   +  ++E +  +I+   P V W+DIA +  
Sbjct: 351 EQNGGMQCKPYGAGPTEPAHPVDERLKNL--EPKMIELIMNEIMDHGPPVNWEDIAGVEF 408

Query: 217 AKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSS 276
           AK  +KE VV PM  P+ F G+R P KG+L+ GPPGTGKTL+ K +A++   TFF++S+S
Sbjct: 409 AKATIKEIVVWPMLRPDIFTGLRGPPKGILLFGPPGTGKTLIGKCIASQSGATFFSISAS 468

Query: 277 TLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQ 336
           +LTSK+ GE EK+VR LF +AR   PA IFIDEIDS+ S+RG   EHE+SRR+K E LVQ
Sbjct: 469 SLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLLSQRGDG-EHESSRRIKTEFLVQ 527

Query: 337 MDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREEL-LRISL 395
           +DG   +SE+      ++V+ ATN P +IDEA RRRL KR+YIPLP A  R+++ + +  
Sbjct: 528 LDGATTSSED-----RILVVGATNRPQEIDEAARRRLVKRLYIPLPEASARKQIVINLMS 582

Query: 396 RELELADDVDLASIAENMEGYSGADITNVCRDASLMAMR----RRIEGLTPEEIRNLSKE 451
           +E     + ++  I +  + +SGAD+T +CR+ASL  +R      I  +TP+++R     
Sbjct: 583 KEQCCLSEEEIEQIVQQSDAFSGADMTQLCREASLGPIRSLQTADIATITPDQVR----- 637

Query: 452 EMHMPTTMEDFEMALKKVSKSVSAADIERYEKWIFEFG 489
               P    DFE A + V  SVS  D+E YE W   FG
Sbjct: 638 ----PIAYIDFENAFRTVRPSVSPKDLELYENWNKTFG 671


>gi|7019569 vacuolar protein sorting factor 4A [Homo sapiens]
          Length = 437

 Score =  248 bits (634), Expect = 7e-66
 Identities = 138/296 (46%), Positives = 185/296 (62%), Gaps = 15/296 (5%)

Query: 153 RCREKKEQNKGREEKNKSPAAVTEPETNKFDSTGYD-----KDLVEALERDIISQNPNVR 207
           R  + K+  + +E+  K P    + E    DS         K L E L   ++ + PN+R
Sbjct: 66  RAEKLKDYLRSKEKHGKKPVKENQSEGKGSDSDSEGDNPEKKKLQEQLMGAVVMEKPNIR 125

Query: 208 WDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATEC- 266
           W+D+A L  AK+ LKEAV+LP+  P  F G R PW+G+L+ GPPGTGK+ LAKAVATE  
Sbjct: 126 WNDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEAN 185

Query: 267 KTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEAS 326
            +TFF+VSSS L SK+ GESEKLV+ LFE+AR + P+ IFIDE+DS+C  R  +E  EA+
Sbjct: 186 NSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRNENES-EAA 244

Query: 327 RRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKG 386
           RR+K E LVQM GVG  ++        +VL ATN PW +D A+RRR EKRIYIPLP    
Sbjct: 245 RRIKTEFLVQMQGVGNNNDG------TLVLGATNIPWVLDSAIRRRFEKRIYIPLPEEAA 298

Query: 387 REELLRISLREL-ELADDVDLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLT 441
           R ++ R+ L        D ++  +A   EGYSGADI+ + RD SLM   R+++  T
Sbjct: 299 RAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADISIIVRD-SLMQPVRKVQSAT 353


>gi|11875211 spastin isoform 1 [Homo sapiens]
          Length = 616

 Score =  246 bits (629), Expect = 3e-65
 Identities = 158/415 (38%), Positives = 227/415 (54%), Gaps = 20/415 (4%)

Query: 79  DSTPLKAAQHDLPASEGEVWSMPVPVERRPSPGPRKRQSSQYSDP--KSHGNRPSTTVRV 136
           DST L      L +  G V     P+    +  PR +   +        H   PS +   
Sbjct: 214 DSTNLACRNGHLQSESGAVPKRKDPLTHTSNSLPRSKTVMKTGSAGLSGHHRAPSYS--- 270

Query: 137 HRSSAQNVHNDRGKAVRCREKKEQNKGREEKNKSPAAVTEPETNKFDSTGYDKDLVEALE 196
             S    V    G A     K      R  K  +P   T  + +  +    D +L   + 
Sbjct: 271 GLSMVSGVKQGSGPAPTTH-KGTPKTNRTNKPSTPTTATRKKKDLKNFRNVDSNLANLIM 329

Query: 197 RDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKT 256
            +I+     V++DDIA    AK+ L+E V+LP   PE F G+R P +G+L+ GPPG GKT
Sbjct: 330 NEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPARGLLLFGPPGNGKT 389

Query: 257 LLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDS-ICS 315
           +LAKAVA E   TFFN+S+++LTSKY GE EKLVR LF +AR   P+ IFIDE+DS +C 
Sbjct: 390 MLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCE 449

Query: 316 RRGTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRRRLEK 375
           RR    EH+ASRR+K E L++ DGV   S  DD    V+V+ ATN P ++DEA+ RR  K
Sbjct: 450 RR--EGEHDASRRLKTEFLIEFDGV--QSAGDD---RVLVMGATNRPQELDEAVLRRFIK 502

Query: 376 RIYIPLPSAKGREELLR-ISLRELELADDVDLASIAENMEGYSGADITNVCRDASLMAMR 434
           R+Y+ LP+ + R  LL+ +  ++       +LA +A   +GYSG+D+T + +DA+L  +R
Sbjct: 503 RVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIR 562

Query: 435 RRIEGLTPEEIRNLSKEEMHMPTTMEDFEMALKKVSKSVSAADIERYEKWIFEFG 489
                L PE+++N+S  EM     + DF  +LKK+ +SVS   +E Y +W  +FG
Sbjct: 563 E----LKPEQVKNMSASEMR-NIRLSDFTESLKKIKRSVSPQTLEAYIRWNKDFG 612


>gi|40806170 spastin isoform 2 [Homo sapiens]
          Length = 584

 Score =  244 bits (623), Expect = 1e-64
 Identities = 140/328 (42%), Positives = 203/328 (61%), Gaps = 14/328 (4%)

Query: 164 REEKNKSPAAVTEPETNKFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVEAKKLLKE 223
           R  K  +P   T  + +  +    D +L   +  +I+     V++DDIA    AK+ L+E
Sbjct: 265 RTNKPSTPTTATRKKKDLKNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQE 324

Query: 224 AVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYR 283
            V+LP   PE F G+R P +G+L+ GPPG GKT+LAKAVA E   TFFN+S+++LTSKY 
Sbjct: 325 IVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYV 384

Query: 284 GESEKLVRLLFEMARFYSPATIFIDEIDS-ICSRRGTSEEHEASRRVKAELLVQMDGVGG 342
           GE EKLVR LF +AR   P+ IFIDE+DS +C RR    EH+ASRR+K E L++ DGV  
Sbjct: 385 GEGEKLVRALFAVARELQPSIIFIDEVDSLLCERR--EGEHDASRRLKTEFLIEFDGV-- 440

Query: 343 TSENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLR-ISLRELELA 401
            S  DD    V+V+ ATN P ++DEA+ RR  KR+Y+ LP+ + R  LL+ +  ++    
Sbjct: 441 QSAGDD---RVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPL 497

Query: 402 DDVDLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSKEEMHMPTTMED 461
              +LA +A   +GYSG+D+T + +DA+L  +R     L PE+++N+S  EM     + D
Sbjct: 498 TQKELAQLARMTDGYSGSDLTALAKDAALGPIRE----LKPEQVKNMSASEMR-NIRLSD 552

Query: 462 FEMALKKVSKSVSAADIERYEKWIFEFG 489
           F  +LKK+ +SVS   +E Y +W  +FG
Sbjct: 553 FTESLKKIKRSVSPQTLEAYIRWNKDFG 580


>gi|17865802 vacuolar protein sorting factor 4B [Homo sapiens]
          Length = 444

 Score =  243 bits (620), Expect = 3e-64
 Identities = 139/314 (44%), Positives = 192/314 (61%), Gaps = 23/314 (7%)

Query: 153 RCREKKEQNKGREEKNKSPAAVTEPETNKFDSTGYDKD------------LVEALERDII 200
           R  + KE  K +E+K + P  V E + +  D  G D D            L   L+  I+
Sbjct: 68  RAEKLKEYLKNKEKKAQKP--VKEGQPSPADEKGNDSDGEGESDDPEKKKLQNQLQGAIV 125

Query: 201 SQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAK 260
            + PNV+W D+A L  AK+ LKEAV+LP+  P  F G R PW+G+L+ GPPGTGK+ LAK
Sbjct: 126 IERPNVKWSDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAK 185

Query: 261 AVATEC-KTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGT 319
           AVATE   +TFF++SSS L SK+ GESEKLV+ LF++AR   P+ IFIDEIDS+C  R +
Sbjct: 186 AVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSR-S 244

Query: 320 SEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYI 379
             E EA+RR+K E LVQM GVG   +ND     ++VL ATN PW +D A+RRR EKRIYI
Sbjct: 245 ENESEAARRIKTEFLVQMQGVG--VDNDG----ILVLGATNIPWVLDSAIRRRFEKRIYI 298

Query: 380 PLPSAKGREELLRISLRELELA-DDVDLASIAENMEGYSGADITNVCRDASLMAMRRRIE 438
           PLP    R  + ++ L   + +  + D   +    +GYSGADI+ + RDA +  +R+   
Sbjct: 299 PLPEPHARAAMFKLHLGTTQNSLTEADFRELGRKTDGYSGADISIIVRDALMQPVRKVQS 358

Query: 439 GLTPEEIRNLSKEE 452
               +++R  S+ +
Sbjct: 359 ATHFKKVRGPSRAD 372


>gi|31377644 ATPase family, AAA domain containing 1 [Homo sapiens]
          Length = 361

 Score =  189 bits (481), Expect = 4e-48
 Identities = 109/276 (39%), Positives = 161/276 (58%), Gaps = 12/276 (4%)

Query: 203 NPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIR--RPWKGVLMVGPPGTGKTLLAK 260
           N +V W DIA L +    LK+ V+LP+     F+  R  +P KGVL+ GPPG GKTL+AK
Sbjct: 85  NMHVTWSDIAGLDDVITDLKDTVILPIKKKHLFENSRLLQPPKGVLLYGPPGCGKTLIAK 144

Query: 261 AVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTS 320
           A A E    F N+  STLT K+ GES+KL   +F +A    P+ IFIDEIDS    R +S
Sbjct: 145 ATAKEAGCRFINLQPSTLTDKWYGESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNR-SS 203

Query: 321 EEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIP 380
            +HEA+  +KA+ +   DG+     + D S  V+V+ ATN P D+D A+ RR+  R +I 
Sbjct: 204 SDHEATAMMKAQFMSLWDGL-----DTDHSCQVIVMGATNRPQDLDSAIMRRMPTRFHIN 258

Query: 381 LPSAKGREELLRISLRELELADDVDLASIAENMEGYSGADITNVCRDASLMAMRRRIEGL 440
            P+ K RE +L++ L+   +   VDL  +A+  +G+SG+D+  +CRDA+L+ +R  +   
Sbjct: 259 QPALKQREAILKLILKNENVDRHVDLLEVAQETDGFSGSDLKEMCRDAALLCVREYVNST 318

Query: 441 TPEEIRNLSKEEMHMPTTMEDFEMALKKVSKSVSAA 476
           + E       E+   P   +D   A++K+ KS  AA
Sbjct: 319 SEES----HDEDEIRPVQQQDLHRAIEKMKKSKDAA 350


>gi|6005942 valosin-containing protein [Homo sapiens]
          Length = 806

 Score =  187 bits (476), Expect = 1e-47
 Identities = 120/304 (39%), Positives = 170/304 (55%), Gaps = 30/304 (9%)

Query: 197 RDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPE-FFKGIRRPWKGVLMVGPPGTGK 255
           R+ + + P V W+DI  L + K+ L+E V  P+  P+ F K    P KGVL  GPPG GK
Sbjct: 465 RETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGK 524

Query: 256 TLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICS 315
           TLLAKA+A EC+  F ++    L + + GESE  VR +F+ AR  +P  +F DE+DSI  
Sbjct: 525 TLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAK 584

Query: 316 RRG--TSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRR-- 371
            RG    +   A+ RV  ++L +MDG+          K V ++ ATN P  ID A+ R  
Sbjct: 585 ARGGNIGDGGGAADRVINQILTEMDGM-------STKKNVFIIGATNRPDIIDPAILRPG 637

Query: 372 RLEKRIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGADITNVCRDASLM 431
           RL++ IYIPLP  K R  +L+ +LR+  +A DVDL  +A+   G+SGAD+T +C+ A  +
Sbjct: 638 RLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKL 697

Query: 432 AMRRRIEGLTPEEIRNLSKEEMHMPTTME-------------DFEMALKKVSKSVSAADI 478
           A+R  IE     EIR   +E    P+ ME              FE A++   +SVS  DI
Sbjct: 698 AIRESIE----SEIRR-ERERQTNPSAMEVEEDDPVPEIRRDHFEEAMRFARRSVSDNDI 752

Query: 479 ERYE 482
            +YE
Sbjct: 753 RKYE 756



 Score =  179 bits (454), Expect = 5e-45
 Identities = 119/312 (38%), Positives = 178/312 (57%), Gaps = 21/312 (6%)

Query: 166 EKNKSPAAVTEPETNKFDSTGYDKDLVEALERDIISQNPN-VRWDDIADLVEAKKLLKEA 224
           E + SP  +  P+T      G      E ++R+   ++ N V +DDI    +    +KE 
Sbjct: 167 ETDPSPYCIVAPDT-VIHCEG------EPIKREDEEESLNEVGYDDIGGCRKQLAQIKEM 219

Query: 225 VVLPMWMPEFFKGIR-RPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYR 283
           V LP+  P  FK I  +P +G+L+ GPPGTGKTL+A+AVA E    FF ++   + SK  
Sbjct: 220 VELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLA 279

Query: 284 GESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGT 343
           GESE  +R  FE A   +PA IFIDE+D+I  +R      E  RR+ ++LL  MDG+   
Sbjct: 280 GESESNLRKAFEEAEKNAPAIIFIDELDAIAPKR-EKTHGEVERRIVSQLLTLMDGLKQR 338

Query: 344 SENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYIPLPSAKGREELLRISLRELELA 401
           +        V+V+AATN P  ID ALRR  R ++ + I +P A GR E+L+I  + ++LA
Sbjct: 339 AH-------VIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLA 391

Query: 402 DDVDLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSKEEMH-MPTTME 460
           DDVDL  +A    G+ GAD+  +C +A+L A+R++++ L   E   +  E M+ +  TM+
Sbjct: 392 DDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMD-LIDLEDETIDAEVMNSLAVTMD 450

Query: 461 DFEMALKKVSKS 472
           DF  AL + + S
Sbjct: 451 DFRWALSQSNPS 462


>gi|64084766 fidgetin [Homo sapiens]
          Length = 759

 Score =  186 bits (473), Expect = 3e-47
 Identities = 121/387 (31%), Positives = 203/387 (52%), Gaps = 29/387 (7%)

Query: 109 SPGPRKRQSSQYSDPK-SHGNRPSTTVRVHRSSAQNVHNDRGKAVRCREKKEQNKGREEK 167
           S   R      YS  K S G+R S +   + S   + H D  + +       Q  G    
Sbjct: 393 SQSSRALTPPSYSTAKNSLGSRSSESFGKYTSPVMSEHGDEHRQLLSHPM--QGPGLRAA 450

Query: 168 NKSPAAVTEPETNKFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVL 227
             S  +V E   N       D  L++ +  +II+Q P V W+DIA L   K ++KE V+ 
Sbjct: 451 TSSNHSVDEQLKNT------DTHLIDLVTNEIITQGPPVDWNDIAGLDLVKAVIKEEVLW 504

Query: 228 PMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESE 287
           P+   + F G+    + +L+ GP GTGKTLL + +A++   TFF ++ S L +K+ GE+E
Sbjct: 505 PVLRSDAFSGLTALPRSILLFGPRGTGKTLLGRCIASQLGATFFKIAGSGLVAKWLGEAE 564

Query: 288 KLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGTSEND 347
           K++   F +AR   P+ IF+ +ID + S +  +EEH    R++ E L+Q+D V  ++E+ 
Sbjct: 565 KIIHASFLVARCRQPSVIFVSDIDMLLSSQ-VNEEHSPVSRMRTEFLMQLDTVLTSAED- 622

Query: 348 DPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELL-RISLRELELADDVDL 406
                ++V+ AT+ P +IDE+LRR   KR+ IPLP +  R +++ ++  +     +D + 
Sbjct: 623 ----QIVVICATSKPEEIDESLRRYFMKRLLIPLPDSTARHQIIVQLLSQHNYCLNDKEF 678

Query: 407 ASIAENMEGYSGADITNVCRDA---SLMAM-RRRIEGLTPEEIRNLSKEEMHMPTTMEDF 462
           A + +  EG+SG D+ ++C++A    L AM    +  + P ++R         P T +DF
Sbjct: 679 ALLVQRTEGFSGLDVAHLCQEAVVGPLHAMPATDLSAIMPSQLR---------PVTYQDF 729

Query: 463 EMALKKVSKSVSAADIERYEKWIFEFG 489
           E A  K+  S+S  +++ Y +W   FG
Sbjct: 730 ENAFCKIQPSISQKELDMYVEWNKMFG 756


>gi|157671927 spermatogenesis associated 5 [Homo sapiens]
          Length = 893

 Score =  173 bits (438), Expect = 4e-43
 Identities = 103/254 (40%), Positives = 150/254 (59%), Gaps = 13/254 (5%)

Query: 190 DLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFF--KGIRRPWKGVLM 247
           D+  +  R+I    PNV W DI  L   K  L++AV  P+  PE F   GI+ P KGVL+
Sbjct: 608 DIRPSAMREIAIDVPNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPP-KGVLL 666

Query: 248 VGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFI 307
            GPPG  KT++AKA+A E    F  +    L +KY GESE+ VR  F  AR  +P+ IF 
Sbjct: 667 YGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIFF 726

Query: 308 DEIDSICSRRGTS-EEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDID 366
           DE+D++   RG+S      + RV A+LL +MDG+       +  K V +LAATN P  ID
Sbjct: 727 DELDALAVERGSSLGAGNVADRVLAQLLTEMDGI-------EQLKDVTILAATNRPDRID 779

Query: 367 EALRR--RLEKRIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGADITNV 424
           +AL R  R+++ IY+PLP A  R E+ ++    + ++++VDL  +    + YSGA+I  V
Sbjct: 780 KALMRPGRIDRIIYVPLPDAATRREIFKLQFHSMPVSNEVDLDELILQTDAYSGAEIVAV 839

Query: 425 CRDASLMAMRRRIE 438
           CR+A+L+A+   I+
Sbjct: 840 CREAALLALEEDIQ 853



 Score =  156 bits (394), Expect = 5e-38
 Identities = 102/275 (37%), Positives = 156/275 (56%), Gaps = 20/275 (7%)

Query: 206 VRWDDIADLVEAKKLLKEAVVLPMWMPEFFK--GIRRPWKGVLMVGPPGTGKTLLAKAVA 263
           V +D I  L    K ++E + LP+  PE FK  GI  P +GVL+ GPPGTGKT++A+AVA
Sbjct: 350 VTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAP-RGVLLYGPPGTGKTMIARAVA 408

Query: 264 TECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEH 323
            E       ++   + SK+ GE+E  +R +F  A    P+ IFIDE+D++C +R    ++
Sbjct: 409 NEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKR-EGAQN 467

Query: 324 EASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYIPL 381
           E  +RV A LL  MDG+G    ++     V+VL ATN P  +D ALRR  R +K I I +
Sbjct: 468 EVEKRVVASLLTLMDGIG----SEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIGV 523

Query: 382 PSAKGREELLRISLREL-ELADDVDLASIAENMEGYSGADITNVCRDASLMAMRRRIE-- 438
           P+A+ R ++L+  LR +  L  + +L  +A +  GY GAD+  +C +A L A+RR ++  
Sbjct: 524 PNAQDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRRILKKQ 583

Query: 439 -GLTPEEIRNLSKEEMHMPTTMEDFEMALKKVSKS 472
             L   ++  L K       T++DF  A+  +  S
Sbjct: 584 PNLPDVKVAGLVK------ITLKDFLQAMNDIRPS 612


>gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens]
          Length = 406

 Score =  168 bits (426), Expect = 9e-42
 Identities = 113/292 (38%), Positives = 163/292 (55%), Gaps = 31/292 (10%)

Query: 199 IISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFK--GIRRPWKGVLMVGPPGTGKT 256
           ++ + P+  ++ I  L +  K +KE + LP+  PE F+  GI +P KGVL+ GPPGTGKT
Sbjct: 139 MVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQP-KGVLLYGPPGTGKT 197

Query: 257 LLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSR 316
           LLA+AVA     TF  VS S L  K+ GE  ++VR LF MAR ++P+ IF+DEIDSI S 
Sbjct: 198 LLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGSS 257

Query: 317 R--GTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRR--R 372
           R  G S      +R   ELL Q+DG   T       K + V+ ATN    +D AL R  R
Sbjct: 258 RLEGGSGGDSEVQRTMLELLNQLDGFEAT-------KNIKVIMATNRIDILDSALLRPGR 310

Query: 373 LEKRIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGADITNVCRDASLMA 432
           ++++I  P P+ + R ++L+I  R++ L   ++L  IAE M G SGA++  VC +A + A
Sbjct: 311 IDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYA 370

Query: 433 MRRRIEGLTPEEIRNLSKEEMHMPTTMEDFEMALKKVSKSVSAADIERYEKW 484
           +R R                  +  T EDFEMA+ KV +  S  ++   + W
Sbjct: 371 LRER-----------------RVHVTQEDFEMAVAKVMQKDSEKNMSIKKLW 405


>gi|229577436 spermatogenesis associated 5-like 1 [Homo sapiens]
          Length = 753

 Score =  166 bits (421), Expect = 3e-41
 Identities = 119/348 (34%), Positives = 184/348 (52%), Gaps = 39/348 (11%)

Query: 154 CREKKEQNKGREEKNKSPAAVTEPETNKFDSTGYDKDLVEALERDIIS--QNPNVRWDDI 211
           CRE         EKN+       P  ++ D     K++  +  R +I       V W++I
Sbjct: 412 CREAAMHALLHSEKNQD-----NPVIDEIDFLEAFKNIQPSSFRSVIGLMDIKPVDWEEI 466

Query: 212 ADLVEAKKLLKEAVVLPMWMP-EFFK-GIRRPWKGVLMVGPPGTGKTLLAKAVATECKTT 269
             L + K  LK+++  P+  P EF + G+ +P KGVL+ GPPG  KT L +A+AT C  +
Sbjct: 467 GGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQP-KGVLLYGPPGCAKTTLVRALATSCHCS 525

Query: 270 FFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEH-EASRR 328
           F +VS + L S + G+SEK++  +F  AR  +PA +F+DEIDSI   R  S+   +   R
Sbjct: 526 FVSVSGADLFSPFVGDSEKVLSQIFRQARASTPAILFLDEIDSILGARSASKTGCDVQER 585

Query: 329 VKAELLVQMDGVG-------GTSENDDP-----SKMVMVLAATNFPWDIDEALRR--RLE 374
           V + LL ++DGVG       G+  +        ++ VM++AATN P  +D AL R  RL+
Sbjct: 586 VLSVLLNELDGVGLKTIERRGSKSSQQEFQEVFNRSVMIIAATNRPDVLDTALLRPGRLD 645

Query: 375 KRIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGADITNVCRDASLMAMR 434
           K IYIP P  KGR  +L++  + + +  DV L ++A     +SGAD+ N+C +A+L+A++
Sbjct: 646 KIIYIPPPDHKGRLSILKVCTKTMPIGPDVSLENLAAETCFFSGADLRNLCTEAALLALQ 705

Query: 435 RRIEGLTPEEIRNLSKEEMHMPTTMEDFEMALKKVSKSVSAADIERYE 482
               GL    ++             E F  +LK V  S+S  D+  YE
Sbjct: 706 E--NGLDATTVK------------QEHFLKSLKTVKPSLSCKDLALYE 739



 Score =  134 bits (338), Expect = 1e-31
 Identities = 85/230 (36%), Positives = 132/230 (57%), Gaps = 18/230 (7%)

Query: 211 IADLVEAKKLLKEAVVLPMWMPEFFK--GIRRPWKGVLMVGPPGTGKTLLAKAVATECKT 268
           +  L EA   L+E + LP+  P      G+  P +GVL+ GPPG GKT L +AVA E   
Sbjct: 202 LGGLSEAADSLRELLRLPLRYPRALTALGLAVP-RGVLLAGPPGVGKTQLVRAVAREAGA 260

Query: 269 TFFNVSSSTLTSKYRGESEKLVRLLFEMARFYS---PATIFIDEIDSICSRRGTSEEHEA 325
               VS+  L     GE+E+ VR +F+ AR  +   P+ +F+DE+D++C +RG+      
Sbjct: 261 ELLAVSAPALQGSRPGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQRGS---RAP 317

Query: 326 SRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYIPLPS 383
             RV A++L  +DG  G  E       V+V+ ATN P  +D ALRR  R ++ + I  P+
Sbjct: 318 ESRVVAQVLTLLDGASGDRE-------VVVVGATNRPDALDPALRRPGRFDREVVIGTPT 370

Query: 384 AKGREELLRISLRELELADDVDLASIAENMEGYSGADITNVCRDASLMAM 433
            K R+E+L++   ++ ++  VDL  +AE   GY GAD+T +CR+A++ A+
Sbjct: 371 LKQRKEILQVITSKMPISSHVDLGLLAEMTVGYVGADLTALCREAAMHAL 420


>gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]
          Length = 403

 Score =  163 bits (412), Expect = 4e-40
 Identities = 108/288 (37%), Positives = 162/288 (56%), Gaps = 32/288 (11%)

Query: 192 VEALERDIISQNP-NVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRR-PWKGVLMVG 249
           V+ L  ++  ++P NV + +I  L E  + L+E + LP+  PE F+ +   P KG L+ G
Sbjct: 129 VDPLVYNMSHEDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYG 188

Query: 250 PPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDE 309
           PPGTGKTLLA+AVA++    F  V SS++  KY GES +L+R +F  AR + P  IF+DE
Sbjct: 189 PPGTGKTLLARAVASQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDE 248

Query: 310 IDSICSRR---GTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDID 366
           ID+I  RR   GTS + E  R +  ELL QMDG        D    V ++ ATN P  +D
Sbjct: 249 IDAIGGRRFSEGTSADREIQRTL-MELLNQMDGF-------DTLHRVKMIMATNRPDTLD 300

Query: 367 EALRR--RLEKRIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGADITNV 424
            AL R  RL+++I+I LP+ + R ++L+I    +    ++D  +I +  +G++GAD+ NV
Sbjct: 301 PALLRPGRLDRKIHIDLPNEQARLDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNV 360

Query: 425 CRDASLMAMRRRIEGLTPEEIRNLSKEEMHMPTTMEDFEMALKKVSKS 472
           C +A + A+R                   H     EDF  A++KV+ S
Sbjct: 361 CTEAGMFAIRAD-----------------HDFVVQEDFMKAVRKVADS 391


>gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens]
          Length = 440

 Score =  161 bits (408), Expect = 1e-39
 Identities = 103/260 (39%), Positives = 149/260 (57%), Gaps = 15/260 (5%)

Query: 200 ISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFK--GIRRPWKGVLMVGPPGTGKTL 257
           + + P   + DI  L    + +KE+V LP+  PE+++  GI+ P KGV++ GPPGTGKTL
Sbjct: 176 VEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPP-KGVILYGPPGTGKTL 234

Query: 258 LAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRR 317
           LAKAVA +   TF  V  S L  KY G+  KLVR LF +A  ++P+ +FIDEID+I ++R
Sbjct: 235 LAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKR 294

Query: 318 --GTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRR--RL 373
               S      +R   ELL Q+DG     +       V V+ ATN    +D AL R  R+
Sbjct: 295 YDSNSGGEREIQRTMLELLNQLDGFDSRGD-------VKVIMATNRIETLDPALIRPGRI 347

Query: 374 EKRIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGADITNVCRDASLMAM 433
           +++I  PLP  K ++ + +I    + LADDV L  +    +  SGADI  +C +A LMA+
Sbjct: 348 DRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMAL 407

Query: 434 RRRIEGLTPEEIRNLSKEEM 453
           R R   +T E+ +  SKE +
Sbjct: 408 RERRMKVTNEDFKK-SKENV 426


>gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens]
          Length = 980

 Score =  159 bits (403), Expect = 4e-39
 Identities = 106/294 (36%), Positives = 159/294 (54%), Gaps = 19/294 (6%)

Query: 204 PNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFK-GIRRPWKGVLMVGPPGTGKTLLAKAV 262
           P+V W D+  L E KK + E + LP+  PE    G+RR   G+L+ GPPGTGKTLLAKAV
Sbjct: 700 PSVSWHDVGGLQEVKKEILETIQLPLEHPELLSLGLRR--SGLLLHGPPGTGKTLLAKAV 757

Query: 263 ATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTS-E 321
           ATEC  TF +V    L + Y G+SE+ VR +F  AR  +P  IF DE+DS+   RG S +
Sbjct: 758 ATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGD 817

Query: 322 EHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYI 379
                 RV ++LL ++DG+  T +       V V+ ATN P  +D AL R  R +K +++
Sbjct: 818 SGGVMDRVVSQLLAELDGLHSTQD-------VFVIGATNRPDLLDPALLRPGRFDKLVFV 870

Query: 380 PLPSAKGRE-ELLRISLRELELADDVDLASIAENM-EGYSGADITNVCRDASLMAMRRRI 437
                +  +  +L    R+ +L   V L ++ +      +GAD+ ++C DA   A++RR+
Sbjct: 871 GANEDRASQLRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRRV 930

Query: 438 EGLTPEEIRNLSKEEMHMPTTMEDFEMALKKVSKSVSAADIERYEKWIFEFGSC 491
             L       L      +  TMED   A  ++  SVS  ++ RY++   +F +C
Sbjct: 931 HDLE----EGLEPGSSALMLTMEDLLQAAARLQPSVSEQELLRYKRIQRKFAAC 980



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 66/239 (27%), Positives = 98/239 (41%), Gaps = 18/239 (7%)

Query: 245 VLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPAT 304
           VL+ GPPG GKT +  A  +        V  S+L ++  G  E  ++ +F  AR   PA 
Sbjct: 466 VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAV 525

Query: 305 IFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLA--ATNFP 362
           + +  +D +   R    E      V   LL+  D +     N  P  MV+     A + P
Sbjct: 526 LLLTAVDLLGRDRDGLGEDARVMAVLRHLLLNEDPL-----NSCPPLMVVATTSRAQDLP 580

Query: 363 WDIDEALRRRLEKRIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGADIT 422
            D+  A    LE    +P  S   R  +LR     L L  +V+LA +A    G+   D+ 
Sbjct: 581 ADVQTAFPHELE----VPALSEGQRLSILRALTAHLPLGQEVNLAQLARRCAGFVVGDLY 636

Query: 423 NVCRDASLMAMRR-----RIEGLTPEEIRNLSKEEMHMPTTMEDFEMALKKVSKSVSAA 476
            +   +S  A  R        GLT E+   L       P   EDF  AL+++  + S A
Sbjct: 637 ALLTHSSRAACTRIKNSGLAGGLTEEDEGELC--AAGFPLLAEDFGQALEQLQTAHSQA 693


>gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens]
          Length = 750

 Score =  159 bits (403), Expect = 4e-39
 Identities = 108/289 (37%), Positives = 165/289 (57%), Gaps = 24/289 (8%)

Query: 204 PNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFK--GIRRPWKGVLMVGPPGTGKTLLAKA 261
           PNV W DI  L + ++ L  A++ P+  P+ FK  G+  P  GVL+ GPPG GKTLLAKA
Sbjct: 470 PNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTP-AGVLLAGPPGCGKTLLAKA 528

Query: 262 VATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSE 321
           VA E    F +V    L + Y GESE+ VR +F+ A+  +P  IF DE+D++C RR +  
Sbjct: 529 VANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRR-SDR 587

Query: 322 EHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYI 379
           E  AS RV  +LL +MDG+       +  + V ++AATN P  ID A+ R  RL+K +++
Sbjct: 588 ETGASVRVVNQLLTEMDGL-------EARQQVFIMAATNRPDIIDPAILRPGRLDKTLFV 640

Query: 380 PLPSAKGREELLRISLR---ELELADDVDLASIAENM--EGYSGADITNVCRDASLMAMR 434
            LP    R  +L+   +   +  L  DV+L +IA ++  + Y+GAD++ + R+AS+ A+R
Sbjct: 641 GLPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALR 700

Query: 435 RRIEGLTPEEIRNLSKEEMHMPTTMEDFEMALKKVSKSVSAADIERYEK 483
           + +        +    E+  +  + + FE A KKV  S+S  D   YE+
Sbjct: 701 QEMAR------QKSGNEKGELKVSHKHFEEAFKKVRSSISKKDQIMYER 743



 Score =  138 bits (347), Expect = 1e-32
 Identities = 113/385 (29%), Positives = 191/385 (49%), Gaps = 35/385 (9%)

Query: 91  PASEGEVWSMPVPVERRPSPG-------PRKRQSSQYSD---PKSHGNRPSTTVRVHRSS 140
           P    +  S+P+    + S G       P  ++ S + D    KS+  +P T ++  + S
Sbjct: 45  PRISSKTGSIPLKTPAKDSEGGWFIDKTPSVKKDSFFLDLSCEKSNPKKPITEIQDSKDS 104

Query: 141 AQNVHNDRGKAVRCREKKEQNKGREEKNKSPAAVTEPETNKFDSTGYDKDLVEALERDII 200
           +    + +      R+ K +NKG + K +    V      + ++    K     LE  I 
Sbjct: 105 SLLESDMK------RKGKLKNKGSKRKKEDLQEVD----GEIEAVLQKKAKARGLEFQI- 153

Query: 201 SQNPNVRWDDIA-DLVEAKKLLKEAVVLPMWMPEFFKGIRR-PWKGVLMVGPPGTGKTLL 258
               NV+++D+  + +  K++ K  +++ M  PE +  +   P +GVL+ GPPG GKTLL
Sbjct: 154 ---SNVKFEDVGGNDMTLKEVCK--MLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLL 208

Query: 259 AKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRG 318
           A A+A E       V++  + S   GESE+ +R LFE A   +P  IFIDEID+I  +R 
Sbjct: 209 AHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKRE 268

Query: 319 TSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRR--RLEKR 376
            + + +  RR+ A+LL  MD +     N   +  V+V+ ATN P  +D ALRR  R ++ 
Sbjct: 269 VASK-DMERRIVAQLLTCMDDL----NNVAATARVLVIGATNRPDSLDPALRRAGRFDRE 323

Query: 377 IYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGADITNVCRDASLMAMRRR 436
           I + +P    RE +L+   R+L L    D   +A    G+ GAD+  +CR+A++ A+ R 
Sbjct: 324 ICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRV 383

Query: 437 IEGLTPEEIRNLSKEEMHMPTTMED 461
           +  L  ++ +N   E++      E+
Sbjct: 384 LMKLQEQQKKNPEMEDLPSKGVQEE 408


>gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens]
          Length = 856

 Score =  159 bits (403), Expect = 4e-39
 Identities = 108/289 (37%), Positives = 165/289 (57%), Gaps = 24/289 (8%)

Query: 204 PNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFK--GIRRPWKGVLMVGPPGTGKTLLAKA 261
           PNV W DI  L + ++ L  A++ P+  P+ FK  G+  P  GVL+ GPPG GKTLLAKA
Sbjct: 576 PNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTP-AGVLLAGPPGCGKTLLAKA 634

Query: 262 VATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSE 321
           VA E    F +V    L + Y GESE+ VR +F+ A+  +P  IF DE+D++C RR +  
Sbjct: 635 VANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRR-SDR 693

Query: 322 EHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYI 379
           E  AS RV  +LL +MDG+       +  + V ++AATN P  ID A+ R  RL+K +++
Sbjct: 694 ETGASVRVVNQLLTEMDGL-------EARQQVFIMAATNRPDIIDPAILRPGRLDKTLFV 746

Query: 380 PLPSAKGREELLRISLR---ELELADDVDLASIAENM--EGYSGADITNVCRDASLMAMR 434
            LP    R  +L+   +   +  L  DV+L +IA ++  + Y+GAD++ + R+AS+ A+R
Sbjct: 747 GLPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALR 806

Query: 435 RRIEGLTPEEIRNLSKEEMHMPTTMEDFEMALKKVSKSVSAADIERYEK 483
           + +        +    E+  +  + + FE A KKV  S+S  D   YE+
Sbjct: 807 QEMAR------QKSGNEKGELKVSHKHFEEAFKKVRSSISKKDQIMYER 849



 Score =  138 bits (347), Expect = 1e-32
 Identities = 113/385 (29%), Positives = 191/385 (49%), Gaps = 35/385 (9%)

Query: 91  PASEGEVWSMPVPVERRPSPG-------PRKRQSSQYSD---PKSHGNRPSTTVRVHRSS 140
           P    +  S+P+    + S G       P  ++ S + D    KS+  +P T ++  + S
Sbjct: 151 PRISSKTGSIPLKTPAKDSEGGWFIDKTPSVKKDSFFLDLSCEKSNPKKPITEIQDSKDS 210

Query: 141 AQNVHNDRGKAVRCREKKEQNKGREEKNKSPAAVTEPETNKFDSTGYDKDLVEALERDII 200
           +    + +      R+ K +NKG + K +    V      + ++    K     LE  I 
Sbjct: 211 SLLESDMK------RKGKLKNKGSKRKKEDLQEVD----GEIEAVLQKKAKARGLEFQI- 259

Query: 201 SQNPNVRWDDIA-DLVEAKKLLKEAVVLPMWMPEFFKGIRR-PWKGVLMVGPPGTGKTLL 258
               NV+++D+  + +  K++ K  +++ M  PE +  +   P +GVL+ GPPG GKTLL
Sbjct: 260 ---SNVKFEDVGGNDMTLKEVCK--MLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLL 314

Query: 259 AKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRG 318
           A A+A E       V++  + S   GESE+ +R LFE A   +P  IFIDEID+I  +R 
Sbjct: 315 AHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKRE 374

Query: 319 TSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRR--RLEKR 376
            + + +  RR+ A+LL  MD +     N   +  V+V+ ATN P  +D ALRR  R ++ 
Sbjct: 375 VASK-DMERRIVAQLLTCMDDL----NNVAATARVLVIGATNRPDSLDPALRRAGRFDRE 429

Query: 377 IYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGADITNVCRDASLMAMRRR 436
           I + +P    RE +L+   R+L L    D   +A    G+ GAD+  +CR+A++ A+ R 
Sbjct: 430 ICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRV 489

Query: 437 IEGLTPEEIRNLSKEEMHMPTTMED 461
           +  L  ++ +N   E++      E+
Sbjct: 490 LMKLQEQQKKNPEMEDLPSKGVQEE 514


>gi|153792536 ATPase family, AAA domain containing 2B [Homo sapiens]
          Length = 1458

 Score =  157 bits (397), Expect = 2e-38
 Identities = 124/403 (30%), Positives = 192/403 (47%), Gaps = 35/403 (8%)

Query: 89  DLPASEGEVWSMPVPVERRPSPGPRKRQSSQYSDPKSHGNRPSTTVRVHRSSAQNVHNDR 148
           ++  +EGE    P  + +R +     R  +    P     R +T   +HRS A+  H  R
Sbjct: 271 EVEEAEGEENDRPYNLRQRKTVD---RYQAPPIVPAHQKKRENTLFDIHRSPARRSHIRR 327

Query: 149 GK-AVRCREKKEQNKGREEKNKSPAAVTEPETNKFDSTGYDKDLVEALER---------- 197
            K A+   +    ++ R E+ KS + +              +DL   + R          
Sbjct: 328 KKHAIHSSDTTSSDEERFERRKSKS-MARARNRCLPMNFRAEDLASGILRERVKVGASLA 386

Query: 198 --DIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIR-RPWKGVLMVGPPGTG 254
             D ++ + +VR+D I  L      LKE VV P+  PE F+  + +P +G L  GPPGTG
Sbjct: 387 DVDPMNIDKSVRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTG 446

Query: 255 KTLLAKAVATEC-----KTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDE 309
           KTL+A+A+A EC     K  FF    +   SK+ GESE+ +RLLF+ A    P+ IF DE
Sbjct: 447 KTLVARALANECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDE 506

Query: 310 IDSICSRRGTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEAL 369
           ID +   R +S + +    + + LL  MDG+    E       ++V+ ATN    ID AL
Sbjct: 507 IDGLAPVR-SSRQDQIHSSIVSTLLALMDGLDNRGE-------IVVIGATNRLDSIDPAL 558

Query: 370 RR--RLEKRIYIPLPSAKGREELLRISLRELE-LADDVDLASIAENMEGYSGADITNVCR 426
           RR  R ++     LP  K R+ +L+I  R+      D  L  +AE   GY GADI  +C 
Sbjct: 559 RRPGRFDREFLFNLPDQKARKHILQIHTRDWNPKLSDAFLGELAEKCVGYCGADIKALCT 618

Query: 427 DASLMAMRRRIEGLTPEEIRNLSKEEMHMPTTMEDFEMALKKV 469
           +A+L+A+RRR   +       L  +   +  + +DF  A++ +
Sbjct: 619 EAALIALRRRYPQIYASS-HKLQLDVSSIVLSAQDFYHAMQNI 660


>gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens]
          Length = 439

 Score =  155 bits (392), Expect = 8e-38
 Identities = 103/282 (36%), Positives = 160/282 (56%), Gaps = 21/282 (7%)

Query: 168 NKSPAAVTEPETNKFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVL 227
           NK    + E    ++DS       V+A+E D   + P  ++ DI  L +  + L EA+VL
Sbjct: 154 NKDSYLILETLPTEYDSR------VKAMEVD---ERPTEQYSDIGGLDKQIQELVEAIVL 204

Query: 228 PMWMPEFFKGIR-RPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGES 286
           PM   E F+ +  +P KGVLM GPPGTGKTLLA+A A + K TF  ++   L   + G+ 
Sbjct: 205 PMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDG 264

Query: 287 EKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEE--HEASRRVKAELLVQMDGVGGTS 344
            KLVR  F +A+  +P+ IFIDE+D+I ++R  SE+      +R   ELL Q+DG     
Sbjct: 265 AKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGF---- 320

Query: 345 ENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYIPLPSAKGREELLRISLRELELAD 402
               P+  V V+AATN    +D AL R  RL+++I  P+P+ + R  +++I  R++ ++ 
Sbjct: 321 ---QPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSP 377

Query: 403 DVDLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEE 444
           DV+   +A   + ++GA    VC +A ++A+RR    LT E+
Sbjct: 378 DVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHED 419


>gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]
          Length = 1390

 Score =  154 bits (389), Expect = 2e-37
 Identities = 103/282 (36%), Positives = 156/282 (55%), Gaps = 20/282 (7%)

Query: 198 DIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIR-RPWKGVLMVGPPGTGKT 256
           D +  + +VR+D +  L      LKE VV P+  PE F+  + +P +G L  GPPGTGKT
Sbjct: 415 DPMQLDSSVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKT 474

Query: 257 LLAKAVATEC-----KTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEID 311
           L+A+A+A EC     +  FF    +   SK+ GESE+ +RLLF+ A    P+ IF DEID
Sbjct: 475 LVARALANECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEID 534

Query: 312 SICSRRGTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRR 371
            +   R +S + +    + + LL  MDG+    E       ++V+ ATN    ID ALRR
Sbjct: 535 GLAPVR-SSRQDQIHSSIVSTLLALMDGLDSRGE-------IVVIGATNRLDSIDPALRR 586

Query: 372 --RLEKRIYIPLPSAKGREELLRISLRELELAD-DVDLASIAENMEGYSGADITNVCRDA 428
             R ++     LP  + R+E+L+I  R+      D  L  +AEN  GY GADI ++C +A
Sbjct: 587 PGRFDREFLFSLPDKEARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSICAEA 646

Query: 429 SLMAMRRRIEGL-TPEEIRNLSKEEMHMPTTMEDFEMALKKV 469
           +L A+RRR   + T  E   L    +++  + +DFE+A++K+
Sbjct: 647 ALCALRRRYPQIYTTSEKLQLDLSSINI--SAKDFEVAMQKM 686


>gi|4506209 proteasome 26S ATPase subunit 2 [Homo sapiens]
          Length = 433

 Score =  147 bits (372), Expect = 2e-35
 Identities = 102/279 (36%), Positives = 143/279 (51%), Gaps = 31/279 (11%)

Query: 200 ISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIR-RPWKGVLMVGPPGTGKTLL 258
           + + P+V + D+    E  + L+E V  P+  PE F  +   P KGVL+ GPPGTGKTL 
Sbjct: 166 VEEKPDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLC 225

Query: 259 AKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRR- 317
           A+AVA      F  V  S L  KY GE  ++VR LFEMAR      IF DEID+I   R 
Sbjct: 226 ARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARF 285

Query: 318 --GTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRR--RL 373
             G   ++E  +R   EL+ Q+DG        DP   + VL ATN P  +D AL R  RL
Sbjct: 286 DDGAGGDNEV-QRTMLELINQLDGF-------DPRGNIKVLMATNRPDTLDPALMRPGRL 337

Query: 374 EKRIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGADITNVCRDASLMAM 433
           +++I   LP  +GR  + +I  R + +  D+    +A      +GA+I +VC +A + A+
Sbjct: 338 DRKIEFSLPDLEGRTHIFKIHARSMSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAI 397

Query: 434 RRRIEGLTPEEIRNLSKEEMHMPTTMEDFEMALKKVSKS 472
           R R         R ++ E        +DF  A+ KV KS
Sbjct: 398 RAR---------RKIATE--------KDFLEAVNKVIKS 419


>gi|4505725 peroxin1 [Homo sapiens]
          Length = 1283

 Score =  147 bits (371), Expect = 2e-35
 Identities = 94/229 (41%), Positives = 128/229 (55%), Gaps = 11/229 (4%)

Query: 208  WDDIADLVEAKKLLKEAVVLPMWMPEFFKGIR-RPWKGVLMVGPPGTGKTLLAKAVATEC 266
            WD I  L E +++L + + LP   PE F  +  R   G+L+ GPPGTGKTLLA  +A E 
Sbjct: 839  WDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARES 898

Query: 267  KTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEAS 326
            +  F +V    L SKY G SE+ VR +F  A+   P  +F DE +SI  RRG  +    +
Sbjct: 899  RMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRG-HDNTGVT 957

Query: 327  RRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYIPLPSA 384
             RV  +LL Q+DGV G        + V VLAAT+ P  ID AL R  RL+K +Y P P  
Sbjct: 958  DRVVNQLLTQLDGVEGL-------QGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQ 1010

Query: 385  KGREELLRISLRELELADDVDLASIAENMEGYSGADITNVCRDASLMAM 433
              R E+L +    L LADDVDL  +A   + ++GAD+  +  +A L A+
Sbjct: 1011 VSRLEILNVLSDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQLEAL 1059



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 53/240 (22%), Positives = 98/240 (40%), Gaps = 32/240 (13%)

Query: 245 VLMVGPPGTGKTLLAKAVATECKTTF-------FNVSSSTLTSKYRGESEKLVRLLFEMA 297
           +L+ G  G+GK+ LAKA+   CK  F         V    L  K     +K + + F  A
Sbjct: 595 LLLTGGKGSGKSTLAKAI---CKEAFDKLDAHVERVDCKALRGKRLENIQKTLEVAFSEA 651

Query: 298 RFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLA 357
            +  P+ + +D++D I       E   +   V+++ L          E      +V ++A
Sbjct: 652 VWMQPSVVLLDDLDLIAGLPAVPEHEHSPDAVQSQRLAHALN-DMIKEFISMGSLVALIA 710

Query: 358 ATNFPWDIDEALRRRLEKRIY-----IPLPSAKGREELLRISLR-----ELELADDVDLA 407
            +     +   L       I+     I  P+ + R E+L   ++     ++    D+DL 
Sbjct: 711 TSQSQQSLHPLLVSAQGVHIFQCVQHIQPPNQEQRCEILCNVIKNKLDCDINKFTDLDLQ 770

Query: 408 SIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSKEEMHMPTTMEDFEMALK 467
            +A+   G+   D T V  D ++ +   R         +++S  E  + TT+ DF+ AL+
Sbjct: 771 HVAKETGGFVARDFT-VLVDRAIHSRLSR---------QSISTREKLVLTTL-DFQKALR 819


>gi|21327685 YME1-like 1 isoform 1 [Homo sapiens]
          Length = 773

 Score =  145 bits (367), Expect = 6e-35
 Identities = 100/278 (35%), Positives = 154/278 (55%), Gaps = 16/278 (5%)

Query: 202 QNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFK--GIRRPWKGVLMVGPPGTGKTLLA 259
           Q  NV ++ +  + EAK+ L+E V   +  P+ F   G + P KG+L+VGPPGTGKTLLA
Sbjct: 332 QMKNVTFEHVKGVEEAKQELQEVVEF-LKNPQKFTILGGKLP-KGILLVGPPGTGKTLLA 389

Query: 260 KAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGT 319
           +AVA E    F+  S S     + G     +R LF  A+  +P  IFIDE+DS+  +R  
Sbjct: 390 RAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIE 449

Query: 320 SEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRI 377
           S  H  SR+   +LL +MDG         P++ V+++ ATNFP  +D AL R  R + ++
Sbjct: 450 SPMHPYSRQTINQLLAEMDGF-------KPNEGVIIIGATNFPEALDNALIRPGRFDMQV 502

Query: 378 YIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGADITNVCRDASLMAMRRRI 437
            +P P  KGR E+L+  L +++    VD   IA    G+SGA++ N+   A+L A     
Sbjct: 503 TVPRPDVKGRTEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGK 562

Query: 438 EGLTPEEIRNLSKEEMHMPTTMEDFEMALKKVSKSVSA 475
           E +T +E+   SK+++ M       E+  K  +K+++A
Sbjct: 563 EMVTMKEL-EFSKDKILMGPERRSVEIDNK--NKTITA 597


>gi|7657689 YME1-like 1 isoform 3 [Homo sapiens]
          Length = 716

 Score =  145 bits (367), Expect = 6e-35
 Identities = 100/278 (35%), Positives = 154/278 (55%), Gaps = 16/278 (5%)

Query: 202 QNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFK--GIRRPWKGVLMVGPPGTGKTLLA 259
           Q  NV ++ +  + EAK+ L+E V   +  P+ F   G + P KG+L+VGPPGTGKTLLA
Sbjct: 275 QMKNVTFEHVKGVEEAKQELQEVVEF-LKNPQKFTILGGKLP-KGILLVGPPGTGKTLLA 332

Query: 260 KAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGT 319
           +AVA E    F+  S S     + G     +R LF  A+  +P  IFIDE+DS+  +R  
Sbjct: 333 RAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIE 392

Query: 320 SEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRI 377
           S  H  SR+   +LL +MDG         P++ V+++ ATNFP  +D AL R  R + ++
Sbjct: 393 SPMHPYSRQTINQLLAEMDGF-------KPNEGVIIIGATNFPEALDNALIRPGRFDMQV 445

Query: 378 YIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGADITNVCRDASLMAMRRRI 437
            +P P  KGR E+L+  L +++    VD   IA    G+SGA++ N+   A+L A     
Sbjct: 446 TVPRPDVKGRTEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGK 505

Query: 438 EGLTPEEIRNLSKEEMHMPTTMEDFEMALKKVSKSVSA 475
           E +T +E+   SK+++ M       E+  K  +K+++A
Sbjct: 506 EMVTMKEL-EFSKDKILMGPERRSVEIDNK--NKTITA 540


>gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit 4
           [Homo sapiens]
          Length = 414

 Score =  144 bits (364), Expect = 1e-34
 Identities = 92/239 (38%), Positives = 137/239 (57%), Gaps = 14/239 (5%)

Query: 202 QNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIR-RPWKGVLMVGPPGTGKTLLAK 260
           Q P+V + DI  +   K+ ++EAV LP+   E +K I   P +GVLM GPPG GKT+LAK
Sbjct: 154 QKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAK 213

Query: 261 AVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRR--- 317
           AVA      F  V  S    KY GE  ++VR +F +A+  +PA IFIDEID+I ++R   
Sbjct: 214 AVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDA 273

Query: 318 GTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRR--RLEK 375
            T  + E  +R+  ELL QMDG        D +  V V+ ATN    +D AL R  RL++
Sbjct: 274 QTGADREV-QRILLELLNQMDGF-------DQNVNVKVIMATNRADTLDPALLRPGRLDR 325

Query: 376 RIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGADITNVCRDASLMAMR 434
           +I  PLP  + +  +      ++ L+++VDL       +  SGADI ++C+++ ++A+R
Sbjct: 326 KIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVR 384


>gi|24430155 proteasome 26S ATPase subunit 4 isoform 2 [Homo
           sapiens]
          Length = 387

 Score =  144 bits (364), Expect = 1e-34
 Identities = 92/239 (38%), Positives = 137/239 (57%), Gaps = 14/239 (5%)

Query: 202 QNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIR-RPWKGVLMVGPPGTGKTLLAK 260
           Q P+V + DI  +   K+ ++EAV LP+   E +K I   P +GVLM GPPG GKT+LAK
Sbjct: 127 QKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAK 186

Query: 261 AVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRR--- 317
           AVA      F  V  S    KY GE  ++VR +F +A+  +PA IFIDEID+I ++R   
Sbjct: 187 AVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDA 246

Query: 318 GTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRR--RLEK 375
            T  + E  +R+  ELL QMDG        D +  V V+ ATN    +D AL R  RL++
Sbjct: 247 QTGADREV-QRILLELLNQMDGF-------DQNVNVKVIMATNRADTLDPALLRPGRLDR 298

Query: 376 RIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGADITNVCRDASLMAMR 434
           +I  PLP  + +  +      ++ L+++VDL       +  SGADI ++C+++ ++A+R
Sbjct: 299 KIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVR 357


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.130    0.375 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,314,658
Number of Sequences: 37866
Number of extensions: 837520
Number of successful extensions: 4157
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 58
Number of HSP's successfully gapped in prelim test: 80
Number of HSP's that attempted gapping in prelim test: 3872
Number of HSP's gapped (non-prelim): 223
length of query: 491
length of database: 18,247,518
effective HSP length: 106
effective length of query: 385
effective length of database: 14,233,722
effective search space: 5479982970
effective search space used: 5479982970
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.