Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 58331117
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|58331117 ankyrin repeat domain 16 isoform c [Homo sapiens]
(304 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|58331117 ankyrin repeat domain 16 isoform c [Homo sapiens] 634 0.0
gi|58331113 ankyrin repeat domain 16 isoform a [Homo sapiens] 585 e-167
gi|58331111 ankyrin repeat domain 16 isoform a [Homo sapiens] 585 e-167
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 102 4e-22
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 102 5e-22
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 101 9e-22
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 100 1e-21
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 100 1e-21
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 100 1e-21
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 100 1e-21
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 100 1e-21
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 100 1e-21
gi|110431370 espin [Homo sapiens] 100 1e-21
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 99 5e-21
gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Ho... 98 1e-20
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 97 2e-20
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 96 3e-20
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 96 3e-20
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 96 3e-20
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 96 4e-20
gi|10863929 ribonuclease L [Homo sapiens] 93 3e-19
gi|30348954 mindbomb homolog 1 [Homo sapiens] 92 6e-19
gi|24308163 fem-1 homolog a [Homo sapiens] 91 1e-18
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 91 2e-18
gi|18079216 CASK interacting protein 1 [Homo sapiens] 90 3e-18
gi|223634006 hypothetical protein LOC441869 [Homo sapiens] 86 5e-17
gi|17864094 feminization 1 homolog a [Homo sapiens] 86 5e-17
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 84 2e-16
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ... 84 2e-16
gi|155969701 espin-like [Homo sapiens] 81 1e-15
>gi|58331117 ankyrin repeat domain 16 isoform c [Homo sapiens]
Length = 304
Score = 634 bits (1635), Expect = 0.0
Identities = 304/304 (100%), Positives = 304/304 (100%)
Query: 1 MAQPGDPRRLCRLVQEGRLRALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAW 60
MAQPGDPRRLCRLVQEGRLRALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAW
Sbjct: 1 MAQPGDPRRLCRLVQEGRLRALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAW 60
Query: 61 GMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVI 120
GMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVI
Sbjct: 61 GMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVI 120
Query: 121 QELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAM 180
QELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAM
Sbjct: 121 QELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAM 180
Query: 181 HGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGA 240
HGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGA
Sbjct: 181 HGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGA 240
Query: 241 QALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKPCIWPVQVSTWPVPSFS 300
QALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKPCIWPVQVSTWPVPSFS
Sbjct: 241 QALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKPCIWPVQVSTWPVPSFS 300
Query: 301 CSRD 304
CSRD
Sbjct: 301 CSRD 304
>gi|58331113 ankyrin repeat domain 16 isoform a [Homo sapiens]
Length = 361
Score = 585 bits (1508), Expect = e-167
Identities = 283/283 (100%), Positives = 283/283 (100%)
Query: 1 MAQPGDPRRLCRLVQEGRLRALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAW 60
MAQPGDPRRLCRLVQEGRLRALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAW
Sbjct: 1 MAQPGDPRRLCRLVQEGRLRALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAW 60
Query: 61 GMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVI 120
GMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVI
Sbjct: 61 GMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVI 120
Query: 121 QELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAM 180
QELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAM
Sbjct: 121 QELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAM 180
Query: 181 HGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGA 240
HGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGA
Sbjct: 181 HGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGA 240
Query: 241 QALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAK 283
QALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAK
Sbjct: 241 QALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAK 283
Score = 49.7 bits (117), Expect = 3e-06
Identities = 62/218 (28%), Positives = 96/218 (44%), Gaps = 22/218 (10%)
Query: 42 HCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLK 101
H A+R G +L YL + ++ + PLH AA GH + V+ LL R C
Sbjct: 142 HIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKR-----CQY 196
Query: 102 KADW------TPLMMACTRKNLGVIQELV-EHGANPLLKNKDGWNSFHIASREGDPLILQ 154
+ D+ T LM A ++ V + L+ EHGA ++ G + H A+ G ++
Sbjct: 197 EPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIR 256
Query: 155 YLLT---VCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMD 211
+L++ V T + + T LH AA GH ++ LL + + +D +AL
Sbjct: 257 FLVSELGVDVDVRATSTHL--TALHYAAKEGHTSTIQTLLS-LGADINSKDEKNRSALHL 313
Query: 212 AIQCGHIDVARLLLDEHGACLSAEDSLG--AQALHRAA 247
A H+ A+ LL +ED G AQ L R A
Sbjct: 314 ACAGQHLACAKFLL--QSGLKDSEDITGTLAQQLPRRA 349
Score = 43.9 bits (102), Expect = 2e-04
Identities = 29/109 (26%), Positives = 50/109 (45%), Gaps = 1/109 (0%)
Query: 20 RALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEA-TNRDYKRPLHEA 78
R L +E A G LH AA G + + +L G+D++ + LH A
Sbjct: 222 RLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYA 281
Query: 79 ASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHG 127
A GH ++ LL GA ++ + + + L +AC ++L + L++ G
Sbjct: 282 AKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSG 330
>gi|58331111 ankyrin repeat domain 16 isoform a [Homo sapiens]
Length = 361
Score = 585 bits (1508), Expect = e-167
Identities = 283/283 (100%), Positives = 283/283 (100%)
Query: 1 MAQPGDPRRLCRLVQEGRLRALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAW 60
MAQPGDPRRLCRLVQEGRLRALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAW
Sbjct: 1 MAQPGDPRRLCRLVQEGRLRALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAW 60
Query: 61 GMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVI 120
GMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVI
Sbjct: 61 GMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVI 120
Query: 121 QELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAM 180
QELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAM
Sbjct: 121 QELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAM 180
Query: 181 HGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGA 240
HGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGA
Sbjct: 181 HGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGA 240
Query: 241 QALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAK 283
QALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAK
Sbjct: 241 QALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAK 283
Score = 49.7 bits (117), Expect = 3e-06
Identities = 62/218 (28%), Positives = 96/218 (44%), Gaps = 22/218 (10%)
Query: 42 HCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLK 101
H A+R G +L YL + ++ + PLH AA GH + V+ LL R C
Sbjct: 142 HIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKR-----CQY 196
Query: 102 KADW------TPLMMACTRKNLGVIQELV-EHGANPLLKNKDGWNSFHIASREGDPLILQ 154
+ D+ T LM A ++ V + L+ EHGA ++ G + H A+ G ++
Sbjct: 197 EPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIR 256
Query: 155 YLLT---VCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMD 211
+L++ V T + + T LH AA GH ++ LL + + +D +AL
Sbjct: 257 FLVSELGVDVDVRATSTHL--TALHYAAKEGHTSTIQTLLS-LGADINSKDEKNRSALHL 313
Query: 212 AIQCGHIDVARLLLDEHGACLSAEDSLG--AQALHRAA 247
A H+ A+ LL +ED G AQ L R A
Sbjct: 314 ACAGQHLACAKFLL--QSGLKDSEDITGTLAQQLPRRA 349
Score = 43.9 bits (102), Expect = 2e-04
Identities = 29/109 (26%), Positives = 50/109 (45%), Gaps = 1/109 (0%)
Query: 20 RALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEA-TNRDYKRPLHEA 78
R L +E A G LH AA G + + +L G+D++ + LH A
Sbjct: 222 RLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYA 281
Query: 79 ASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHG 127
A GH ++ LL GA ++ + + + L +AC ++L + L++ G
Sbjct: 282 AKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQSG 330
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 102 bits (254), Expect = 4e-22
Identities = 81/248 (32%), Positives = 121/248 (48%), Gaps = 6/248 (2%)
Query: 36 AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
+G T +H AA GH ++++ L G TN + LH AA G + VRYL+ GA
Sbjct: 432 SGLTPIHVAAFMGHVNIVSQLMHH-GASPNTTNVRGETALHMAARSGQAEVVRYLVQDGA 490
Query: 96 AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQY 155
V+ K D TPL ++ ++Q+L++ GA+P G+ H+++REG + +
Sbjct: 491 QVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAF 550
Query: 156 LLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQC 215
LL + +K TPLH AA +G LE +LL++ PD G+T L A
Sbjct: 551 LLD-HGASLSITTKKGFTPLHVAAKYGKLEVANLLLQK-SASPDAAGKSGLTPLHVAAHY 608
Query: 216 GHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHL 275
+ VA LLLD+ GA A G LH AA Q + L+ E G D + T +
Sbjct: 609 DNQKVALLLLDQ-GASPHAAAKNGYTPLHIAAKKNQMDIATTLL-EYGADANA-VTRQGI 665
Query: 276 TALHYAAK 283
++H AA+
Sbjct: 666 ASVHLAAQ 673
Score = 96.3 bits (238), Expect = 3e-20
Identities = 80/245 (32%), Positives = 120/245 (48%), Gaps = 8/245 (3%)
Query: 39 TLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVD 98
T LH AA GH V L + + A + PLH A + LL GA++
Sbjct: 369 TALHVAAHCGHYKVAKVLLDKKA-NPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQ 427
Query: 99 CLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLT 158
+ ++ TP+ +A ++ ++ +L+ HGA+P N G + H+A+R G +++YL
Sbjct: 428 AVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYL-- 485
Query: 159 VCPGAW-KTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGH 217
V GA + ++K +TPLH +A G + V+ LL++ P+ G T L + + GH
Sbjct: 486 VQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQ-GASPNAATTSGYTPLHLSAREGH 544
Query: 218 IDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTA 277
DVA LLD HGA LS G LH AA G+ E L+ + D A + LT
Sbjct: 545 EDVAAFLLD-HGASLSITTKKGFTPLHVAAKYGKLEVANLLLQK-SASPDA-AGKSGLTP 601
Query: 278 LHYAA 282
LH AA
Sbjct: 602 LHVAA 606
Score = 92.8 bits (229), Expect = 3e-19
Identities = 78/243 (32%), Positives = 117/243 (48%), Gaps = 8/243 (3%)
Query: 41 LHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCL 100
LH AAR A L + + + ++ PLH AA G+ + LL R AAVD
Sbjct: 206 LHIAARKDDTKAAALLLQN-DNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFT 264
Query: 101 KKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLL-TV 159
+ D TPL +A R N +++ L++ GA K +DG H +R G +++ LL
Sbjct: 265 ARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRA 324
Query: 160 CPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHID 219
P KT++ + +PLH A HL V++LL+ D N +TAL A CGH
Sbjct: 325 APILSKTKNGL--SPLHMATQGDHLNCVQLLLQH-NVPVDDVTNDYLTALHVAAHCGHYK 381
Query: 220 VARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALH 279
VA++LLD+ A +A+ G LH A + + + L+ G + T + LT +H
Sbjct: 382 VAKVLLDKK-ANPNAKALNGFTPLHIACKKNRIKVMELLLKH-GASIQA-VTESGLTPIH 438
Query: 280 YAA 282
AA
Sbjct: 439 VAA 441
Score = 90.5 bits (223), Expect = 2e-18
Identities = 72/248 (29%), Positives = 122/248 (49%), Gaps = 12/248 (4%)
Query: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
G LH A++ GH +V++ L + +++A + LH A+ G + V+ L+ GA
Sbjct: 74 GLNALHLASKEGHVEVVSELLQREA-NVDAATKKGNTALHIASLAGQAEVVKVLVTNGAN 132
Query: 97 VDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYL 156
V+ + +TPL MA +L V++ L+++GA+ L +DG+ +A ++G ++ L
Sbjct: 133 VNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLL 192
Query: 157 LTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCG 216
L T+ K+R LH AA +A +LL+ D G T L A G
Sbjct: 193 LEN-----DTKGKVRLPALHIAARKDDTKAAALLLQN-DNNADVESKSGFTPLHIAAHYG 246
Query: 217 HIDVARLLLDEHGAC-LSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHL 275
+I+VA LLL+ A +A + + LH A+ G ++ L+ + G +D + T L
Sbjct: 247 NINVATLLLNRAAAVDFTARNDI--TPLHVASKRGNANMVKLLL-DRGAKIDAK-TRDGL 302
Query: 276 TALHYAAK 283
T LH A+
Sbjct: 303 TPLHCGAR 310
Score = 87.4 bits (215), Expect = 1e-17
Identities = 65/188 (34%), Positives = 88/188 (46%), Gaps = 3/188 (1%)
Query: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
G T LH AA+ D+ L E +G D A R +H AA GH D V LLGR A
Sbjct: 631 GYTPLHIAAKKNQMDIATTLLE-YGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNAN 689
Query: 97 VDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYL 156
V+ K+ TPL +A + V + LV GA+ + K G+ H+ G+ I+ +L
Sbjct: 690 VNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFL 749
Query: 157 LTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCG 216
L ++K TPLH AA GH + VLL+ P+ G TAL A + G
Sbjct: 750 LQHSAKV-NAKTKNGYTPLHQAAQQGHTHIINVLLQN-NASPNELTVNGNTALGIARRLG 807
Query: 217 HIDVARLL 224
+I V L
Sbjct: 808 YISVVDTL 815
Score = 82.4 bits (202), Expect = 4e-16
Identities = 76/272 (27%), Positives = 113/272 (41%), Gaps = 40/272 (14%)
Query: 24 EELQAAGGCPGPA---GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAAS 80
++L G P A G T LH +AR GH DV A+L + G + T + PLH AA
Sbjct: 516 QQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDH-GASLSITTKKGFTPLHVAAK 574
Query: 81 MGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWN- 139
G + LL + A+ D K+ TPL +A N V L++ GA+P K+G+
Sbjct: 575 YGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTP 634
Query: 140 --------------------------------SFHIASREGDPLILQYLLTVCPGAWKTE 167
S H+A++EG ++ LL
Sbjct: 635 LHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANV-NLS 693
Query: 168 SKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDE 227
+K TPLH AA + +VL+ + + D + G T L G+I + LL +
Sbjct: 694 NKSGLTPLHLAAQEDRVNVAEVLVNQGAH-VDAQTKMGYTPLHVGCHYGNIKIVNFLL-Q 751
Query: 228 HGACLSAEDSLGAQALHRAAVTGQDEAIRFLV 259
H A ++A+ G LH+AA G I L+
Sbjct: 752 HSAKVNAKTKNGYTPLHQAAQQGHTHIINVLL 783
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 102 bits (253), Expect = 5e-22
Identities = 72/239 (30%), Positives = 121/239 (50%), Gaps = 14/239 (5%)
Query: 33 PGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLG 92
P G T LH AA G+ + L L G D ++ + PLH AA+ + C+ L+G
Sbjct: 401 PDDFGRTCLHAAAAGGNLECLNLLLNT-GADFNKKDKFGRSPLHYAAANCNYQCLFALVG 459
Query: 93 RGAAVDCLKKADWTPLMMACTRKNLG-VIQELVEHGANPLLKNKDGWNSFHIASREGDPL 151
GA+V+ L + TPL A T G ++ L+ + ANP +++K G+N+ H ++ G L
Sbjct: 460 SGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRL 519
Query: 152 ILQYLLTVCP-----------GAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDY 200
LQ + + P ++++ +PLH AA HGH +A++VL++ + D
Sbjct: 520 CLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSL-LDLDV 578
Query: 201 RDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLV 259
R++ G T L A GH++ +L+++ + L + L +H AA G E +R L+
Sbjct: 579 RNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLI 637
Score = 86.7 bits (213), Expect = 2e-17
Identities = 73/247 (29%), Positives = 112/247 (45%), Gaps = 8/247 (3%)
Query: 36 AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
AG T LH AA GH +++ L G +I A ++ +R +H AA MGH + V+ L+ GA
Sbjct: 139 AGRTALHHAAFSGHGEMVKLLLSR-GANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGA 197
Query: 96 AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQY 155
V C K +TPL A + + V++ L++ G + N G H+A G +++
Sbjct: 198 EVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNE 257
Query: 156 LLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQC 215
L+ C +++ TPLH AA H LL + + + G T L
Sbjct: 258 LID-CGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALH 316
Query: 216 GHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRAT---- 271
G ++ ++ + GA + ED G LH AA G + I L++ G D R
Sbjct: 317 GRFSRSQTII-QSGAVIDCEDKNGNTPLHIAARYGHELLINTLITS-GADTAKRGIHGMF 374
Query: 272 STHLTAL 278
HL AL
Sbjct: 375 PLHLAAL 381
Score = 86.3 bits (212), Expect = 3e-17
Identities = 81/254 (31%), Positives = 116/254 (45%), Gaps = 13/254 (5%)
Query: 33 PGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRD-CVRYLL 91
P G+T LH A +G V+ L + G + N PLH AA+ H C+ L+
Sbjct: 235 PNAYGNTPLHVACYNGQDVVVNELIDC-GAIVNQKNEKGFTPLHFAAASTHGALCLELLV 293
Query: 92 GRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPL 151
G GA V+ K TPL M Q +++ GA ++K+G HIA+R G L
Sbjct: 294 GNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHEL 353
Query: 152 ILQYLLTVCPGAWKTESKIR-RTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALM 210
++ L+T GA + I PLH AA+ G + + LL ++ D D+ G T L
Sbjct: 354 LINTLIT--SGADTAKRGIHGMFPLHLAALSGFSDCCRKLLS-SGFDIDTPDDFGRTCLH 410
Query: 211 DAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGV--DVDV 268
A G+++ LLL+ GA + +D G LH AA + + LV D+D
Sbjct: 411 AAAAGGNLECLNLLLNT-GADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDE 469
Query: 269 RATSTHLTALHYAA 282
R T LHYAA
Sbjct: 470 RG----CTPLHYAA 479
Score = 85.9 bits (211), Expect = 4e-17
Identities = 68/236 (28%), Positives = 107/236 (45%), Gaps = 47/236 (19%)
Query: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDI-----------EATNRDYKRPLHEAASMGHRD 85
G +H +A +GHR L +A +D+ ++ NR PLH AA GH
Sbjct: 505 GYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQ 564
Query: 86 CVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIAS 145
+ L+ +D + TPL +A + ++ + L+ GA+ L+K+
Sbjct: 565 ALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKD----------- 613
Query: 146 REGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRC--QYEPDYRDN 203
Y+L +RTP+H AA +GH E +++L+ Q D +D
Sbjct: 614 ---------YIL-------------KRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDG 651
Query: 204 CGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLV 259
G T LM ++ GH D LL++ GA + A+D G ALHR AVTG +E + L+
Sbjct: 652 NGQTPLMLSVLNGHTDCVYSLLNK-GANVDAKDKWGRTALHRGAVTGHEECVDALL 706
Score = 83.2 bits (204), Expect = 3e-16
Identities = 77/282 (27%), Positives = 112/282 (39%), Gaps = 44/282 (15%)
Query: 41 LHCAARHGHRDVLAYLAEAWGMDIEATN-------------------------------R 69
LH AA HGH L L ++ +D++ N +
Sbjct: 554 LHLAAYHGHHQALEVLVQSL-LDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVK 612
Query: 70 DY---KRPLHEAASMGHRDCVRYLLGRGA---AVDCLKKADWTPLMMACTRKNLGVIQEL 123
DY + P+H AA+ GH +C+R L+G AVD TPLM++ + + L
Sbjct: 613 DYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSL 672
Query: 124 VEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGH 183
+ GAN K+K G + H + G + LL +S+ RTP+H +A GH
Sbjct: 673 LNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSR-GRTPIHLSAACGH 731
Query: 184 LEAVKVLLKRC---QYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGA 240
+ + LL+ P DN G TAL A GH LLL++ +
Sbjct: 732 IGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQE--VFQKTEGNAF 789
Query: 241 QALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAA 282
LH A + + A L+ LG + S T LH AA
Sbjct: 790 SPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAA 831
Score = 81.6 bits (200), Expect = 8e-16
Identities = 63/206 (30%), Positives = 103/206 (50%), Gaps = 6/206 (2%)
Query: 63 DIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADW-TPLMMACTRKNLGVIQ 121
D+ + + + PLH AA +G + + L+ GA V+ K + W TPL A + +Q
Sbjct: 33 DVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNA-KDSKWLTPLHRAVASCSEEAVQ 91
Query: 122 ELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMH 181
L++H A+ ++K+ HIA+ + L+ + + RT LH AA
Sbjct: 92 VLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNV-NVSDRAGRTALHHAAFS 150
Query: 182 GHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQ 241
GH E VK+LL R + D A+ A GHI+V +LL+ HGA ++ +D
Sbjct: 151 GHGEMVKLLLSRGANINAF-DKKDRRAIHWAAYMGHIEVVKLLV-SHGAEVTCKDKKSYT 208
Query: 242 ALHRAAVTGQDEAIRFLVSELGVDVD 267
LH AA +G +++L+ +LGVD++
Sbjct: 209 PLHAAASSGMISVVKYLL-DLGVDMN 233
Score = 79.3 bits (194), Expect = 4e-15
Identities = 71/250 (28%), Positives = 115/250 (46%), Gaps = 10/250 (4%)
Query: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
G T L + +GH D + L G +++A ++ + LH A GH +CV LL GA
Sbjct: 653 GQTPLMLSVLNGHTDCVYSLLNK-GANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAK 711
Query: 97 VDCLKKADWTPLMMACTRKNLGVIQELVEHGA----NPLLKNKDGWNSFHIASREGDPLI 152
TP+ ++ ++GV+ L++ A NP + G+ + H A G
Sbjct: 712 CLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETC 771
Query: 153 LQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYE-PDYRDNCGVTALMD 211
++ LL KTE +PLH A ++ + A ++L+ + D+ G T L
Sbjct: 772 VELLLEQ-EVFQKTEGNAF-SPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHA 829
Query: 212 AIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRAT 271
A H++ +LLL H A +++ DS G L AA GQ + LVS ++ ++
Sbjct: 830 AAFTDHVECLQLLLS-HNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDN 888
Query: 272 STHLTALHYA 281
S + TALH A
Sbjct: 889 SKN-TALHLA 897
Score = 78.6 bits (192), Expect = 6e-15
Identities = 72/244 (29%), Positives = 113/244 (46%), Gaps = 6/244 (2%)
Query: 39 TLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVD 98
T LH AA G +++ L + G + A + + PLH A + + V+ LL A V+
Sbjct: 43 TPLHAAAYLGDAEIIELLILS-GARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVN 101
Query: 99 CLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLT 158
K TPL +A K + + LV +N + ++ G + H A+ G +++ LL+
Sbjct: 102 ARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLS 161
Query: 159 VCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHI 218
+ K RR +H AA GH+E VK+L+ E +D T L A G I
Sbjct: 162 RGANINAFDKKDRRA-IHWAAYMGHIEVVKLLVSH-GAEVTCKDKKSYTPLHAAASSGMI 219
Query: 219 DVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTAL 278
V + LLD G ++ ++ G LH A GQD + L+ + G V+ + T L
Sbjct: 220 SVVKYLLD-LGVDMNEPNAYGNTPLHVACYNGQDVVVNELI-DCGAIVN-QKNEKGFTPL 276
Query: 279 HYAA 282
H+AA
Sbjct: 277 HFAA 280
Score = 74.7 bits (182), Expect = 9e-14
Identities = 62/222 (27%), Positives = 104/222 (46%), Gaps = 6/222 (2%)
Query: 63 DIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQE 122
++ ++R + LH AA GH + V+ LL RGA ++ K D + A ++ V++
Sbjct: 132 NVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKL 191
Query: 123 LVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTE-SKIRRTPLHTAAMH 181
LV HGA K+K + H A+ G +++YLL + G E + TPLH A +
Sbjct: 192 LVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDL--GVDMNEPNAYGNTPLHVACYN 249
Query: 182 GHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQ 241
G V L+ C + ++ G T L A H + LL +GA ++ + G
Sbjct: 250 GQDVVVNELID-CGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKT 308
Query: 242 ALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAK 283
LH A+ G+ + ++ + G +D + + T LH AA+
Sbjct: 309 PLHMTALHGRFSRSQTII-QSGAVIDCEDKNGN-TPLHIAAR 348
Score = 67.0 bits (162), Expect = 2e-11
Identities = 78/253 (30%), Positives = 102/253 (40%), Gaps = 16/253 (6%)
Query: 32 CPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLL 91
C G+T LH AAR+GH ++ L + G D PLH AA G DC R LL
Sbjct: 334 CEDKNGNTPLHIAARYGHELLINTLITS-GADTAKRGIHGMFPLHLAALSGFSDCCRKLL 392
Query: 92 GRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPL 151
G +D T L A NL + L+ GA+ K+K G + H A+ +
Sbjct: 393 SSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQ 452
Query: 152 ILQYLLTVCPGAWKTESKIRR-TPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALM 210
L L V GA + R TPLH AA L R P RD G A+
Sbjct: 453 CLFAL--VGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVH 510
Query: 211 DAIQCGHIDVARLLLDEHGACLSAEDS-----------LGAQALHRAAVTGQDEAIRFLV 259
+ GH +L+ E + E S LH AA G +A+ LV
Sbjct: 511 YSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLV 570
Query: 260 SELGVDVDVRATS 272
L +D+DVR +S
Sbjct: 571 QSL-LDLDVRNSS 582
Score = 62.0 bits (149), Expect = 6e-10
Identities = 71/272 (26%), Positives = 108/272 (39%), Gaps = 35/272 (12%)
Query: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
G T LH AA H + L G D+ ++D K PLH A G + ++ GA
Sbjct: 272 GFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAV 331
Query: 97 VDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYL 156
+DC K TPL +A + +I L+ GA+ + G H+A+ G + L
Sbjct: 332 IDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKL 391
Query: 157 LTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTAL-MDAIQC 215
L+ T RT LH AA G+LE + +LL + + +D G + L A C
Sbjct: 392 LSSGFDI-DTPDDFGRTCLHAAAAGGNLECLNLLLNTGA-DFNKKDKFGRSPLHYAAANC 449
Query: 216 GHIDVARLL--------LDEHGA--------------CLS----------AEDSLGAQAL 243
+ + L+ LDE G CL D G A+
Sbjct: 450 NYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAV 509
Query: 244 HRAAVTGQDEAIRFLVSELGVDVDVRATSTHL 275
H +A G ++ + SE +DV + + T +
Sbjct: 510 HYSAAYGHRLCLQLIASETPLDVLMETSGTDM 541
Score = 57.4 bits (137), Expect = 2e-08
Identities = 46/157 (29%), Positives = 70/157 (44%), Gaps = 8/157 (5%)
Query: 41 LHCAARHGHRDVLAYLAEAWGMDI-EATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDC 99
LHCA + + L + G I AT+ + PLH AA H +C++ LL A V+
Sbjct: 792 LHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNS 851
Query: 100 LKKADWTPLMMACTRKNLGVIQELVEHGANPL-LKNKDGWNSFHIASREGDP----LILQ 154
+ TPLMMA ++ LV + L L++ + H+A +G LIL+
Sbjct: 852 VDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILE 911
Query: 155 YLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLL 191
+ + +TPLH AA +G V+ LL
Sbjct: 912 KITD--RNLINATNAALQTPLHVAARNGLTMVVQELL 946
Score = 55.1 bits (131), Expect = 8e-08
Identities = 68/236 (28%), Positives = 101/236 (42%), Gaps = 17/236 (7%)
Query: 37 GDTLLHCAARHGHRDVL-AYLAEAWGMDIE---ATNRDYKRPLHEAASMGHRDCVRYLLG 92
G T +H +A GH VL A L A MD A N Y LH A GH CV LL
Sbjct: 719 GRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTA-LHWACYNGHETCVELLLE 777
Query: 93 RGAAVDCLKKAD---WTPLMMACTRKNLGVIQELVEHGANPLLKNKD--GWNSFHIASRE 147
+ + +K + ++PL A N G + L++ ++ D G H A+
Sbjct: 778 Q----EVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFT 833
Query: 148 GDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVT 207
LQ LL+ +S +TPL AA +G V++L+ E +DN T
Sbjct: 834 DHVECLQLLLSHNAQVNSVDST-GKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNT 892
Query: 208 ALMDAIQCGHIDVARLLLDE--HGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSE 261
AL A GH A L+L++ ++A ++ LH AA G ++ L+ +
Sbjct: 893 ALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGK 948
Score = 40.4 bits (93), Expect = 0.002
Identities = 28/82 (34%), Positives = 41/82 (50%), Gaps = 2/82 (2%)
Query: 38 DTLLHCAARHGHR-DVLAYLAEAWGMD-IEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
+T LH A GH L L + + I ATN + PLH AA G V+ LLG+GA
Sbjct: 891 NTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGA 950
Query: 96 AVDCLKKADWTPLMMACTRKNL 117
+V + + +TP + K++
Sbjct: 951 SVLAVDENGYTPALACAPNKDV 972
Score = 36.2 bits (82), Expect = 0.037
Identities = 27/105 (25%), Positives = 46/105 (43%), Gaps = 3/105 (2%)
Query: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA- 95
G T L AA +G + + L + ++ + LH A S GH +L +
Sbjct: 856 GKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITD 915
Query: 96 --AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGW 138
++ A TPL +A V+QEL+ GA+ L +++G+
Sbjct: 916 RNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGY 960
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 101 bits (251), Expect = 9e-22
Identities = 83/244 (34%), Positives = 123/244 (50%), Gaps = 8/244 (3%)
Query: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
G T L AA GH DV+ L E G D++ T+ + + PL AASMGH V LL GAA
Sbjct: 748 GMTPLLVAAYEGHVDVVDLLLEG-GADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAA 806
Query: 97 VDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYL 156
VD + T L +A + N+ V++ L++ G + ++ GW H+A+ EG LI + L
Sbjct: 807 VDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEAL 866
Query: 157 LTVCPGAWKTE-SKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQC 215
+ GA E R P A+ GH + V++LL+ + D R G AL A
Sbjct: 867 IE--QGARTNEIDNDGRIPFILASQEGHYDCVQILLEN-KSNIDQRGYDGRNALRVAALE 923
Query: 216 GHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHL 275
GH D+ LL HGA ++ +D+ G L+ A+ Q + + E G +V+ + +
Sbjct: 924 GHRDIVELLF-SHGADVNCKDADGRPTLYILALENQLTMAEYFL-ENGANVEA-SDAEGR 980
Query: 276 TALH 279
TALH
Sbjct: 981 TALH 984
Score = 95.5 bits (236), Expect = 5e-20
Identities = 71/216 (32%), Positives = 112/216 (51%), Gaps = 6/216 (2%)
Query: 44 AARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKA 103
A++ GH D + L E +I+ D + L AA GHRD V L GA V+C K A
Sbjct: 887 ASQEGHYDCVQILLENKS-NIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNC-KDA 944
Query: 104 DWTPLMMACTRKN-LGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPG 162
D P + +N L + + +E+GAN + +G + H++ +G ++Q L+
Sbjct: 945 DGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHAD 1004
Query: 163 AWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVAR 222
+++ +R+ L +AA GH++ V++L++ D+ N G TAL A Q GHIDV +
Sbjct: 1005 VNAADNE-KRSALQSAAWQGHVKVVQLLIEHGAV-VDHTCNQGATALCIAAQEGHIDVVQ 1062
Query: 223 LLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFL 258
+LL EHGA + D G A+ AA G + I+ L
Sbjct: 1063 VLL-EHGADPNHADQFGRTAMRVAAKNGHSQIIKLL 1097
Score = 90.9 bits (224), Expect = 1e-18
Identities = 81/250 (32%), Positives = 119/250 (47%), Gaps = 10/250 (4%)
Query: 36 AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
AG T LH AA GHR + L E E N D + P A+ GH DCV+ LL +
Sbjct: 846 AGWTPLHMAAFEGHRLICEALIEQGARTNEIDN-DGRIPFILASQEGHYDCVQILLENKS 904
Query: 96 AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQY 155
+D L +A + +++ L HGA+ K+ DG + +I + E + +Y
Sbjct: 905 NIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEY 964
Query: 156 LLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYR--DNCGVTALMDAI 213
L ++++ RT LH + GH+E V+VL+ Y D DN +AL A
Sbjct: 965 FLENGANVEASDAE-GRTALHVSCWQGHMEMVQVLI---AYHADVNAADNEKRSALQSAA 1020
Query: 214 QCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATST 273
GH+ V +LL+ EHGA + + GA AL AA G + ++ L+ E G D + A
Sbjct: 1021 WQGHVKVVQLLI-EHGAVVDHTCNQGATALCIAAQEGHIDVVQVLL-EHGADPN-HADQF 1077
Query: 274 HLTALHYAAK 283
TA+ AAK
Sbjct: 1078 GRTAMRVAAK 1087
Score = 78.6 bits (192), Expect = 6e-15
Identities = 75/229 (32%), Positives = 104/229 (45%), Gaps = 11/229 (4%)
Query: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
G T L AAR GH V+ L G +I T++D L AA GH + V LL G
Sbjct: 578 GHTPLTLAARQGHTKVVNCLIGC-GANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVK 636
Query: 97 VDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYL 156
VDC T L A + ++ L++HGA + +G + A+ G I+++L
Sbjct: 637 VDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHL 696
Query: 157 LTVCPGAWKTESKI-RRTPLHTAAM-----HGHLEAVKVLLKRCQYEPDYRDNCGVTALM 210
L GA + RT L AA+ GH V +L+ R E D+ D G+T L+
Sbjct: 697 LD--HGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDR-GAEVDHCDKDGMTPLL 753
Query: 211 DAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLV 259
A GH+DV LLL E GA + D+ G L AA G + L+
Sbjct: 754 VAAYEGHVDVVDLLL-EGGADVDHTDNNGRTPLLAAASMGHASVVNTLL 801
Score = 68.6 bits (166), Expect = 7e-12
Identities = 65/212 (30%), Positives = 98/212 (46%), Gaps = 9/212 (4%)
Query: 61 GMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVI 120
G + + + + L AA G D V L+ RGA ++ TPL +A + + V+
Sbjct: 535 GASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVV 594
Query: 121 QELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAM 180
L+ GAN ++DGW + A+ G ++ LL ++ RT L AA
Sbjct: 595 NCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADAD-SRTALRAAAW 653
Query: 181 HGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGA 240
GH + V LL+ E + DN G TAL+ A GH ++ LLD HGA ++ ED G
Sbjct: 654 GGHEDIVLNLLQH-GAEVNKADNEGRTALIAAAYMGHREIVEHLLD-HGAEVNHEDVDGR 711
Query: 241 QALHRAAV-----TGQDEAIRFLVSELGVDVD 267
AL AA+ G + L+ + G +VD
Sbjct: 712 TALSVAALCVPASKGHASVVSLLI-DRGAEVD 742
Score = 62.0 bits (149), Expect = 6e-10
Identities = 37/120 (30%), Positives = 62/120 (51%), Gaps = 1/120 (0%)
Query: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
G T LH + GH +++ L A+ D+ A + + + L AA GH V+ L+ GA
Sbjct: 979 GRTALHVSCWQGHMEMVQVLI-AYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAV 1037
Query: 97 VDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYL 156
VD T L +A ++ V+Q L+EHGA+P ++ G + +A++ G I++ L
Sbjct: 1038 VDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLL 1097
Score = 61.6 bits (148), Expect = 8e-10
Identities = 57/188 (30%), Positives = 86/188 (45%), Gaps = 4/188 (2%)
Query: 80 SMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWN 139
++ D +R LL GA+V+ T L A +L V+ LV GA+ +++ G
Sbjct: 521 ALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHT 580
Query: 140 SFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPD 199
+A+R+G ++ L+ C + T L +AA GH E V LL + D
Sbjct: 581 PLTLAARQGHTKVVNCLIG-CGANINHTDQDGWTALRSAAWGGHTEVVSALL-YAGVKVD 638
Query: 200 YRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLV 259
D TAL A GH D+ LL +HGA ++ D+ G AL AA G E + L+
Sbjct: 639 CADADSRTALRAAAWGGHEDIVLNLL-QHGAEVNKADNEGRTALIAAAYMGHREIVEHLL 697
Query: 260 SELGVDVD 267
G +V+
Sbjct: 698 DH-GAEVN 704
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 100 bits (250), Expect = 1e-21
Identities = 76/234 (32%), Positives = 114/234 (48%), Gaps = 7/234 (2%)
Query: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
G T LH AA GH ++ L G +++A R+ + PLH A G +++LL GA
Sbjct: 494 GKTPLHVAAYFGHVSLVKLLTSQ-GAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAV 552
Query: 97 VDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYL 156
D L ++ + PL A R + + L+ +GA+ L GW H+A+ +G L + +L
Sbjct: 553 PDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGH-LEIIHL 611
Query: 157 LTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQ-C 215
L + TPLH AA HG EAV L +C +P+ + G T L A+Q
Sbjct: 612 LAESHANMGALGAVNWTPLHLAARHGE-EAVVSALLQCGADPNAAEQSGWTPLHLAVQRS 670
Query: 216 GHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVR 269
+ V LL EH A + A + +G H AA+ G ++ LV E G +DV+
Sbjct: 671 TFLSVINLL--EHHANVHARNKVGWTPAHLAALKGNTAILKVLV-EAGAQLDVQ 721
Score = 95.9 bits (237), Expect = 4e-20
Identities = 83/251 (33%), Positives = 109/251 (43%), Gaps = 7/251 (2%)
Query: 32 CPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLL 91
C +G T L AA+ D+ A L A G D + D PLH AA G R LL
Sbjct: 390 CQTASGYTPLLIAAQDQQPDLCALLL-AHGADANRVDEDGWAPLHFAAQNGDDGTARLLL 448
Query: 92 GRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPL 151
GA VD ++ WTPL +A V + LV A+P L +G H+A+ G
Sbjct: 449 DHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVS 508
Query: 152 ILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMD 211
+++ LLT + + RTPLH A G + A++ LLK PD D G L
Sbjct: 509 LVK-LLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAV-PDALDQSGYGPLHT 566
Query: 212 AIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLV---SELGVDVDV 268
A G + ++LL +GA L G LH AA G E I L + +G V
Sbjct: 567 AAARGKYLICKMLL-RYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAV 625
Query: 269 RATSTHLTALH 279
T HL A H
Sbjct: 626 NWTPLHLAARH 636
Score = 81.3 bits (199), Expect = 1e-15
Identities = 60/188 (31%), Positives = 91/188 (48%), Gaps = 7/188 (3%)
Query: 74 PLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLK 133
PLH + G + VR LL VDC + +TPL++A + + L+ HGA+
Sbjct: 365 PLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRV 424
Query: 134 NKDGWNSFHIASREGDPLILQYLLT--VCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLL 191
++DGW H A++ GD + LL C A + E TPLH AA + ++L+
Sbjct: 425 DEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREG---WTPLHLAAQNNFENVARLLV 481
Query: 192 KRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQ 251
R Q +P+ + G T L A GH+ + +LL + GA L A+ LH A G+
Sbjct: 482 SR-QADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQ-GAELDAQQRNLRTPLHLAVERGK 539
Query: 252 DEAIRFLV 259
AI+ L+
Sbjct: 540 VRAIQHLL 547
Score = 70.5 bits (171), Expect = 2e-12
Identities = 45/125 (36%), Positives = 65/125 (52%), Gaps = 1/125 (0%)
Query: 33 PGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLG 92
P G T LH AA GH +++ LAE+ ++ A PLH AA G V LL
Sbjct: 589 PTHQGWTPLHLAAYKGHLEIIHLLAESHA-NMGALGAVNWTPLHLAARHGEEAVVSALLQ 647
Query: 93 RGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLI 152
GA + +++ WTPL +A R + L+EH AN +NK GW H+A+ +G+ I
Sbjct: 648 CGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAI 707
Query: 153 LQYLL 157
L+ L+
Sbjct: 708 LKVLV 712
Score = 52.4 bits (124), Expect = 5e-07
Identities = 42/135 (31%), Positives = 57/135 (42%), Gaps = 1/135 (0%)
Query: 22 LKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASM 81
L E A G G T LH AARHG V++ L + G D A + PLH A
Sbjct: 611 LLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQC-GADPNAAEQSGWTPLHLAVQR 669
Query: 82 GHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSF 141
V LL A V K WTP +A + N +++ LVE GA +++
Sbjct: 670 STFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPL 729
Query: 142 HIASREGDPLILQYL 156
+A R I+ +L
Sbjct: 730 QLALRSRKQGIMSFL 744
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 100 bits (250), Expect = 1e-21
Identities = 84/246 (34%), Positives = 127/246 (51%), Gaps = 8/246 (3%)
Query: 39 TLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVD 98
T LHCAAR+GH + L + G I+A ++ P+H AA H DCVR LL A +D
Sbjct: 307 TPLHCAARNGHVRISEILLDH-GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 365
Query: 99 CLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLL- 157
+ TPL +A + V + L++ GA P + +G+ HIA ++ +++ LL
Sbjct: 366 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 425
Query: 158 TVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGH 217
T TES + TPLH A+ GHL VK LL+R P+ + T L A + GH
Sbjct: 426 TGASIDAVTESGL--TPLHVASFMGHLPIVKNLLQR-GASPNVSNVKVETPLHMAARAGH 482
Query: 218 IDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTA 277
+VA+ LL ++ A ++A+ LH AA G ++ L+ E + ++ T+ H T
Sbjct: 483 TEVAKYLL-QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL-ENNANPNLATTAGH-TP 539
Query: 278 LHYAAK 283
LH AA+
Sbjct: 540 LHIAAR 545
Score = 97.1 bits (240), Expect = 2e-20
Identities = 83/250 (33%), Positives = 119/250 (47%), Gaps = 10/250 (4%)
Query: 36 AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
+G T LH A+ GH ++ L + G +N + PLH AA GH + +YLL A
Sbjct: 436 SGLTPLHVASFMGHLPIVKNLLQR-GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 494
Query: 96 AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGD-PLILQ 154
V+ K D TPL A + +++ L+E+ ANP L G HIA+REG +L
Sbjct: 495 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLA 554
Query: 155 YLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQ 214
L A T+ TPLH AA +G + ++LL+R P+ G+T L A+
Sbjct: 555 LLEKEASQACMTKKGF--TPLHVAAKYGKVRVAELLLER-DAHPNAAGKNGLTPLHVAVH 611
Query: 215 CGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTH 274
++D+ +LLL G+ S + G LH AA Q E R L+ G A S
Sbjct: 612 HNNLDIVKLLLPRGGSPHSPAWN-GYTPLHIAAKQNQVEVARSLLQYGG---SANAESVQ 667
Query: 275 -LTALHYAAK 283
+T LH AA+
Sbjct: 668 GVTPLHLAAQ 677
Score = 96.7 bits (239), Expect = 2e-20
Identities = 74/243 (30%), Positives = 121/243 (49%), Gaps = 10/243 (4%)
Query: 41 LHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCL 100
LH A++ GH ++ L + +E T + LH AA G + VR L+ GA V+
Sbjct: 82 LHLASKEGHVKMVVELLHK-EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQ 140
Query: 101 KKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVC 160
+ +TPL MA +L V++ L+E+GAN + +DG+ +A ++G ++ +L+
Sbjct: 141 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLIN-- 198
Query: 161 PGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDV 220
+ T+ K+R LH AA + VLL+ PD G T L A +++V
Sbjct: 199 ---YGTKGKVRLPALHIAARNDDTRTAAVLLQN-DPNPDVLSKTGFTPLHIAAHYENLNV 254
Query: 221 ARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHY 280
A+LLL+ GA ++ G LH A+ G +R L+ + G ++ + T LT LH
Sbjct: 255 AQLLLN-RGASVNFTPQNGITPLHIASRRGNVIMVRLLL-DRGAQIETK-TKDELTPLHC 311
Query: 281 AAK 283
AA+
Sbjct: 312 AAR 314
Score = 88.2 bits (217), Expect = 8e-18
Identities = 80/247 (32%), Positives = 117/247 (47%), Gaps = 6/247 (2%)
Query: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
G T LH AA + + +V L G + T ++ PLH A+ G+ VR LL RGA
Sbjct: 239 GFTPLHIAAHYENLNVAQLLLNR-GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 297
Query: 97 VDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYL 156
++ K + TPL A ++ + + L++HGA K K+G + H+A+ +GD L L
Sbjct: 298 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA-QGDHLDCVRL 356
Query: 157 LTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCG 216
L + TPLH AA GH KVLL + +P+ R G T L A +
Sbjct: 357 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK-GAKPNSRALNGFTPLHIACKKN 415
Query: 217 HIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLT 276
H+ V LLL + GA + A G LH A+ G ++ L+ + G +V T
Sbjct: 416 HVRVMELLL-KTGASIDAVTESGLTPLHVASFMGHLPIVKNLL-QRGASPNVSNVKVE-T 472
Query: 277 ALHYAAK 283
LH AA+
Sbjct: 473 PLHMAAR 479
Score = 87.4 bits (215), Expect = 1e-17
Identities = 69/235 (29%), Positives = 109/235 (46%), Gaps = 4/235 (1%)
Query: 25 ELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHR 84
E +A+ C G T LH AA++G V L E A ++ PLH A +
Sbjct: 557 EKEASQACMTKKGFTPLHVAAKYGKVRVAELLLER-DAHPNAAGKNGLTPLHVAVHHNNL 615
Query: 85 DCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIA 144
D V+ LL RG + +TPL +A + + V + L+++G + ++ G H+A
Sbjct: 616 DIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA 675
Query: 145 SREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNC 204
++EG ++ LL+ +K TPLH A GH+ VL+K D
Sbjct: 676 AQEGHAEMVALLLSKQANG-NLGNKSGLTPLHLVAQEGHVPVADVLIKH-GVMVDATTRM 733
Query: 205 GVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLV 259
G T L A G+I + + LL +H A ++A+ LG LH+AA G + + L+
Sbjct: 734 GYTPLHVASHYGNIKLVKFLL-QHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 787
Score = 78.6 bits (192), Expect = 6e-15
Identities = 66/219 (30%), Positives = 102/219 (46%), Gaps = 8/219 (3%)
Query: 14 VQEGRLRALKEELQAAGGCPGPA--GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDY 71
V L +K L G PA G T LH AA+ +V L + +G A +
Sbjct: 610 VHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ-YGGSANAESVQG 668
Query: 72 KRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPL 131
PLH AA GH + V LL + A + K+ TPL + ++ V L++HG
Sbjct: 669 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 728
Query: 132 LKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLL 191
+ G+ H+AS G+ ++++LL ++K+ +PLH AA GH + V +LL
Sbjct: 729 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADV-NAKTKLGYSPLHQAAQQGHTDIVTLLL 787
Query: 192 KRCQYEPDYRDNCGVTALMDAIQCGHI---DVARLLLDE 227
K P+ + G T L A + G+I DV +++ DE
Sbjct: 788 KN-GASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDE 825
Score = 52.0 bits (123), Expect = 7e-07
Identities = 54/186 (29%), Positives = 84/186 (45%), Gaps = 5/186 (2%)
Query: 93 RGAAVDCLKKADW-TPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPL 151
R + D KKAD T + A NL + + +G + N++G N H+AS+EG
Sbjct: 33 RNRSRDRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVK 92
Query: 152 ILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMD 211
++ LL +T +K T LH AA+ G E V+ L+ + + G T L
Sbjct: 93 MVVELLHK-EIILETTTKKGNTALHIAALAGQDEVVRELV-NYGANVNAQSQKGFTPLYM 150
Query: 212 AIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRAT 271
A Q H++V + LL E+GA + G L A G + + L++ G VR
Sbjct: 151 AAQENHLEVVKFLL-ENGANQNVATEDGFTPLAVALQQGHENVVAHLIN-YGTKGKVRLP 208
Query: 272 STHLTA 277
+ H+ A
Sbjct: 209 ALHIAA 214
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 100 bits (250), Expect = 1e-21
Identities = 84/246 (34%), Positives = 127/246 (51%), Gaps = 8/246 (3%)
Query: 39 TLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVD 98
T LHCAAR+GH + L + G I+A ++ P+H AA H DCVR LL A +D
Sbjct: 274 TPLHCAARNGHVRISEILLDH-GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332
Query: 99 CLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLL- 157
+ TPL +A + V + L++ GA P + +G+ HIA ++ +++ LL
Sbjct: 333 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 392
Query: 158 TVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGH 217
T TES + TPLH A+ GHL VK LL+R P+ + T L A + GH
Sbjct: 393 TGASIDAVTESGL--TPLHVASFMGHLPIVKNLLQR-GASPNVSNVKVETPLHMAARAGH 449
Query: 218 IDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTA 277
+VA+ LL ++ A ++A+ LH AA G ++ L+ E + ++ T+ H T
Sbjct: 450 TEVAKYLL-QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL-ENNANPNLATTAGH-TP 506
Query: 278 LHYAAK 283
LH AA+
Sbjct: 507 LHIAAR 512
Score = 97.1 bits (240), Expect = 2e-20
Identities = 83/250 (33%), Positives = 119/250 (47%), Gaps = 10/250 (4%)
Query: 36 AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
+G T LH A+ GH ++ L + G +N + PLH AA GH + +YLL A
Sbjct: 403 SGLTPLHVASFMGHLPIVKNLLQR-GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461
Query: 96 AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGD-PLILQ 154
V+ K D TPL A + +++ L+E+ ANP L G HIA+REG +L
Sbjct: 462 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLA 521
Query: 155 YLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQ 214
L A T+ TPLH AA +G + ++LL+R P+ G+T L A+
Sbjct: 522 LLEKEASQACMTKKGF--TPLHVAAKYGKVRVAELLLER-DAHPNAAGKNGLTPLHVAVH 578
Query: 215 CGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTH 274
++D+ +LLL G+ S + G LH AA Q E R L+ G A S
Sbjct: 579 HNNLDIVKLLLPRGGSPHSPAWN-GYTPLHIAAKQNQVEVARSLLQYGG---SANAESVQ 634
Query: 275 -LTALHYAAK 283
+T LH AA+
Sbjct: 635 GVTPLHLAAQ 644
Score = 96.7 bits (239), Expect = 2e-20
Identities = 74/243 (30%), Positives = 121/243 (49%), Gaps = 10/243 (4%)
Query: 41 LHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCL 100
LH A++ GH ++ L + +E T + LH AA G + VR L+ GA V+
Sbjct: 49 LHLASKEGHVKMVVELLHK-EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQ 107
Query: 101 KKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVC 160
+ +TPL MA +L V++ L+E+GAN + +DG+ +A ++G ++ +L+
Sbjct: 108 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLIN-- 165
Query: 161 PGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDV 220
+ T+ K+R LH AA + VLL+ PD G T L A +++V
Sbjct: 166 ---YGTKGKVRLPALHIAARNDDTRTAAVLLQN-DPNPDVLSKTGFTPLHIAAHYENLNV 221
Query: 221 ARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHY 280
A+LLL+ GA ++ G LH A+ G +R L+ + G ++ + T LT LH
Sbjct: 222 AQLLLN-RGASVNFTPQNGITPLHIASRRGNVIMVRLLL-DRGAQIETK-TKDELTPLHC 278
Query: 281 AAK 283
AA+
Sbjct: 279 AAR 281
Score = 88.2 bits (217), Expect = 8e-18
Identities = 80/247 (32%), Positives = 117/247 (47%), Gaps = 6/247 (2%)
Query: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
G T LH AA + + +V L G + T ++ PLH A+ G+ VR LL RGA
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNR-GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264
Query: 97 VDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYL 156
++ K + TPL A ++ + + L++HGA K K+G + H+A+ +GD L L
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA-QGDHLDCVRL 323
Query: 157 LTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCG 216
L + TPLH AA GH KVLL + +P+ R G T L A +
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK-GAKPNSRALNGFTPLHIACKKN 382
Query: 217 HIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLT 276
H+ V LLL + GA + A G LH A+ G ++ L+ + G +V T
Sbjct: 383 HVRVMELLL-KTGASIDAVTESGLTPLHVASFMGHLPIVKNLL-QRGASPNVSNVKVE-T 439
Query: 277 ALHYAAK 283
LH AA+
Sbjct: 440 PLHMAAR 446
Score = 87.4 bits (215), Expect = 1e-17
Identities = 69/235 (29%), Positives = 109/235 (46%), Gaps = 4/235 (1%)
Query: 25 ELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHR 84
E +A+ C G T LH AA++G V L E A ++ PLH A +
Sbjct: 524 EKEASQACMTKKGFTPLHVAAKYGKVRVAELLLER-DAHPNAAGKNGLTPLHVAVHHNNL 582
Query: 85 DCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIA 144
D V+ LL RG + +TPL +A + + V + L+++G + ++ G H+A
Sbjct: 583 DIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA 642
Query: 145 SREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNC 204
++EG ++ LL+ +K TPLH A GH+ VL+K D
Sbjct: 643 AQEGHAEMVALLLSKQANG-NLGNKSGLTPLHLVAQEGHVPVADVLIKH-GVMVDATTRM 700
Query: 205 GVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLV 259
G T L A G+I + + LL +H A ++A+ LG LH+AA G + + L+
Sbjct: 701 GYTPLHVASHYGNIKLVKFLL-QHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754
Score = 78.6 bits (192), Expect = 6e-15
Identities = 66/219 (30%), Positives = 102/219 (46%), Gaps = 8/219 (3%)
Query: 14 VQEGRLRALKEELQAAGGCPGPA--GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDY 71
V L +K L G PA G T LH AA+ +V L + +G A +
Sbjct: 577 VHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ-YGGSANAESVQG 635
Query: 72 KRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPL 131
PLH AA GH + V LL + A + K+ TPL + ++ V L++HG
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695
Query: 132 LKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLL 191
+ G+ H+AS G+ ++++LL ++K+ +PLH AA GH + V +LL
Sbjct: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADV-NAKTKLGYSPLHQAAQQGHTDIVTLLL 754
Query: 192 KRCQYEPDYRDNCGVTALMDAIQCGHI---DVARLLLDE 227
K P+ + G T L A + G+I DV +++ DE
Sbjct: 755 KN-GASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDE 792
Score = 48.9 bits (115), Expect = 6e-06
Identities = 48/172 (27%), Positives = 77/172 (44%), Gaps = 4/172 (2%)
Query: 106 TPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWK 165
T + A NL + + +G + N++G N H+AS+EG ++ LL +
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK-EIILE 72
Query: 166 TESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLL 225
T +K T LH AA+ G E V+ L+ + + G T L A Q H++V + LL
Sbjct: 73 TTTKKGNTALHIAALAGQDEVVRELV-NYGANVNAQSQKGFTPLYMAAQENHLEVVKFLL 131
Query: 226 DEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTA 277
E+GA + G L A G + + L++ G VR + H+ A
Sbjct: 132 -ENGANQNVATEDGFTPLAVALQQGHENVVAHLIN-YGTKGKVRLPALHIAA 181
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 100 bits (250), Expect = 1e-21
Identities = 84/246 (34%), Positives = 127/246 (51%), Gaps = 8/246 (3%)
Query: 39 TLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVD 98
T LHCAAR+GH + L + G I+A ++ P+H AA H DCVR LL A +D
Sbjct: 274 TPLHCAARNGHVRISEILLDH-GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332
Query: 99 CLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLL- 157
+ TPL +A + V + L++ GA P + +G+ HIA ++ +++ LL
Sbjct: 333 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 392
Query: 158 TVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGH 217
T TES + TPLH A+ GHL VK LL+R P+ + T L A + GH
Sbjct: 393 TGASIDAVTESGL--TPLHVASFMGHLPIVKNLLQR-GASPNVSNVKVETPLHMAARAGH 449
Query: 218 IDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTA 277
+VA+ LL ++ A ++A+ LH AA G ++ L+ E + ++ T+ H T
Sbjct: 450 TEVAKYLL-QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL-ENNANPNLATTAGH-TP 506
Query: 278 LHYAAK 283
LH AA+
Sbjct: 507 LHIAAR 512
Score = 97.1 bits (240), Expect = 2e-20
Identities = 83/250 (33%), Positives = 119/250 (47%), Gaps = 10/250 (4%)
Query: 36 AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
+G T LH A+ GH ++ L + G +N + PLH AA GH + +YLL A
Sbjct: 403 SGLTPLHVASFMGHLPIVKNLLQR-GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461
Query: 96 AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGD-PLILQ 154
V+ K D TPL A + +++ L+E+ ANP L G HIA+REG +L
Sbjct: 462 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLA 521
Query: 155 YLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQ 214
L A T+ TPLH AA +G + ++LL+R P+ G+T L A+
Sbjct: 522 LLEKEASQACMTKKGF--TPLHVAAKYGKVRVAELLLER-DAHPNAAGKNGLTPLHVAVH 578
Query: 215 CGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTH 274
++D+ +LLL G+ S + G LH AA Q E R L+ G A S
Sbjct: 579 HNNLDIVKLLLPRGGSPHSPAWN-GYTPLHIAAKQNQVEVARSLLQYGG---SANAESVQ 634
Query: 275 -LTALHYAAK 283
+T LH AA+
Sbjct: 635 GVTPLHLAAQ 644
Score = 96.7 bits (239), Expect = 2e-20
Identities = 74/243 (30%), Positives = 121/243 (49%), Gaps = 10/243 (4%)
Query: 41 LHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCL 100
LH A++ GH ++ L + +E T + LH AA G + VR L+ GA V+
Sbjct: 49 LHLASKEGHVKMVVELLHK-EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQ 107
Query: 101 KKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVC 160
+ +TPL MA +L V++ L+E+GAN + +DG+ +A ++G ++ +L+
Sbjct: 108 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLIN-- 165
Query: 161 PGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDV 220
+ T+ K+R LH AA + VLL+ PD G T L A +++V
Sbjct: 166 ---YGTKGKVRLPALHIAARNDDTRTAAVLLQN-DPNPDVLSKTGFTPLHIAAHYENLNV 221
Query: 221 ARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHY 280
A+LLL+ GA ++ G LH A+ G +R L+ + G ++ + T LT LH
Sbjct: 222 AQLLLN-RGASVNFTPQNGITPLHIASRRGNVIMVRLLL-DRGAQIETK-TKDELTPLHC 278
Query: 281 AAK 283
AA+
Sbjct: 279 AAR 281
Score = 88.2 bits (217), Expect = 8e-18
Identities = 80/247 (32%), Positives = 117/247 (47%), Gaps = 6/247 (2%)
Query: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
G T LH AA + + +V L G + T ++ PLH A+ G+ VR LL RGA
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNR-GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264
Query: 97 VDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYL 156
++ K + TPL A ++ + + L++HGA K K+G + H+A+ +GD L L
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA-QGDHLDCVRL 323
Query: 157 LTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCG 216
L + TPLH AA GH KVLL + +P+ R G T L A +
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK-GAKPNSRALNGFTPLHIACKKN 382
Query: 217 HIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLT 276
H+ V LLL + GA + A G LH A+ G ++ L+ + G +V T
Sbjct: 383 HVRVMELLL-KTGASIDAVTESGLTPLHVASFMGHLPIVKNLL-QRGASPNVSNVKVE-T 439
Query: 277 ALHYAAK 283
LH AA+
Sbjct: 440 PLHMAAR 446
Score = 87.4 bits (215), Expect = 1e-17
Identities = 69/235 (29%), Positives = 109/235 (46%), Gaps = 4/235 (1%)
Query: 25 ELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHR 84
E +A+ C G T LH AA++G V L E A ++ PLH A +
Sbjct: 524 EKEASQACMTKKGFTPLHVAAKYGKVRVAELLLER-DAHPNAAGKNGLTPLHVAVHHNNL 582
Query: 85 DCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIA 144
D V+ LL RG + +TPL +A + + V + L+++G + ++ G H+A
Sbjct: 583 DIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA 642
Query: 145 SREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNC 204
++EG ++ LL+ +K TPLH A GH+ VL+K D
Sbjct: 643 AQEGHAEMVALLLSKQANG-NLGNKSGLTPLHLVAQEGHVPVADVLIKH-GVMVDATTRM 700
Query: 205 GVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLV 259
G T L A G+I + + LL +H A ++A+ LG LH+AA G + + L+
Sbjct: 701 GYTPLHVASHYGNIKLVKFLL-QHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754
Score = 78.6 bits (192), Expect = 6e-15
Identities = 66/219 (30%), Positives = 102/219 (46%), Gaps = 8/219 (3%)
Query: 14 VQEGRLRALKEELQAAGGCPGPA--GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDY 71
V L +K L G PA G T LH AA+ +V L + +G A +
Sbjct: 577 VHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ-YGGSANAESVQG 635
Query: 72 KRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPL 131
PLH AA GH + V LL + A + K+ TPL + ++ V L++HG
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695
Query: 132 LKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLL 191
+ G+ H+AS G+ ++++LL ++K+ +PLH AA GH + V +LL
Sbjct: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADV-NAKTKLGYSPLHQAAQQGHTDIVTLLL 754
Query: 192 KRCQYEPDYRDNCGVTALMDAIQCGHI---DVARLLLDE 227
K P+ + G T L A + G+I DV +++ DE
Sbjct: 755 KN-GASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDE 792
Score = 48.9 bits (115), Expect = 6e-06
Identities = 48/172 (27%), Positives = 77/172 (44%), Gaps = 4/172 (2%)
Query: 106 TPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWK 165
T + A NL + + +G + N++G N H+AS+EG ++ LL +
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK-EIILE 72
Query: 166 TESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLL 225
T +K T LH AA+ G E V+ L+ + + G T L A Q H++V + LL
Sbjct: 73 TTTKKGNTALHIAALAGQDEVVRELV-NYGANVNAQSQKGFTPLYMAAQENHLEVVKFLL 131
Query: 226 DEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTA 277
E+GA + G L A G + + L++ G VR + H+ A
Sbjct: 132 -ENGANQNVATEDGFTPLAVALQQGHENVVAHLIN-YGTKGKVRLPALHIAA 181
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 100 bits (250), Expect = 1e-21
Identities = 84/246 (34%), Positives = 127/246 (51%), Gaps = 8/246 (3%)
Query: 39 TLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVD 98
T LHCAAR+GH + L + G I+A ++ P+H AA H DCVR LL A +D
Sbjct: 274 TPLHCAARNGHVRISEILLDH-GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332
Query: 99 CLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLL- 157
+ TPL +A + V + L++ GA P + +G+ HIA ++ +++ LL
Sbjct: 333 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 392
Query: 158 TVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGH 217
T TES + TPLH A+ GHL VK LL+R P+ + T L A + GH
Sbjct: 393 TGASIDAVTESGL--TPLHVASFMGHLPIVKNLLQR-GASPNVSNVKVETPLHMAARAGH 449
Query: 218 IDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTA 277
+VA+ LL ++ A ++A+ LH AA G ++ L+ E + ++ T+ H T
Sbjct: 450 TEVAKYLL-QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL-ENNANPNLATTAGH-TP 506
Query: 278 LHYAAK 283
LH AA+
Sbjct: 507 LHIAAR 512
Score = 97.1 bits (240), Expect = 2e-20
Identities = 83/250 (33%), Positives = 119/250 (47%), Gaps = 10/250 (4%)
Query: 36 AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
+G T LH A+ GH ++ L + G +N + PLH AA GH + +YLL A
Sbjct: 403 SGLTPLHVASFMGHLPIVKNLLQR-GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461
Query: 96 AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGD-PLILQ 154
V+ K D TPL A + +++ L+E+ ANP L G HIA+REG +L
Sbjct: 462 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLA 521
Query: 155 YLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQ 214
L A T+ TPLH AA +G + ++LL+R P+ G+T L A+
Sbjct: 522 LLEKEASQACMTKKGF--TPLHVAAKYGKVRVAELLLER-DAHPNAAGKNGLTPLHVAVH 578
Query: 215 CGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTH 274
++D+ +LLL G+ S + G LH AA Q E R L+ G A S
Sbjct: 579 HNNLDIVKLLLPRGGSPHSPAWN-GYTPLHIAAKQNQVEVARSLLQYGG---SANAESVQ 634
Query: 275 -LTALHYAAK 283
+T LH AA+
Sbjct: 635 GVTPLHLAAQ 644
Score = 96.7 bits (239), Expect = 2e-20
Identities = 74/243 (30%), Positives = 121/243 (49%), Gaps = 10/243 (4%)
Query: 41 LHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCL 100
LH A++ GH ++ L + +E T + LH AA G + VR L+ GA V+
Sbjct: 49 LHLASKEGHVKMVVELLHK-EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQ 107
Query: 101 KKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVC 160
+ +TPL MA +L V++ L+E+GAN + +DG+ +A ++G ++ +L+
Sbjct: 108 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLIN-- 165
Query: 161 PGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDV 220
+ T+ K+R LH AA + VLL+ PD G T L A +++V
Sbjct: 166 ---YGTKGKVRLPALHIAARNDDTRTAAVLLQN-DPNPDVLSKTGFTPLHIAAHYENLNV 221
Query: 221 ARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHY 280
A+LLL+ GA ++ G LH A+ G +R L+ + G ++ + T LT LH
Sbjct: 222 AQLLLN-RGASVNFTPQNGITPLHIASRRGNVIMVRLLL-DRGAQIETK-TKDELTPLHC 278
Query: 281 AAK 283
AA+
Sbjct: 279 AAR 281
Score = 88.2 bits (217), Expect = 8e-18
Identities = 80/247 (32%), Positives = 117/247 (47%), Gaps = 6/247 (2%)
Query: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
G T LH AA + + +V L G + T ++ PLH A+ G+ VR LL RGA
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNR-GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264
Query: 97 VDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYL 156
++ K + TPL A ++ + + L++HGA K K+G + H+A+ +GD L L
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA-QGDHLDCVRL 323
Query: 157 LTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCG 216
L + TPLH AA GH KVLL + +P+ R G T L A +
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK-GAKPNSRALNGFTPLHIACKKN 382
Query: 217 HIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLT 276
H+ V LLL + GA + A G LH A+ G ++ L+ + G +V T
Sbjct: 383 HVRVMELLL-KTGASIDAVTESGLTPLHVASFMGHLPIVKNLL-QRGASPNVSNVKVE-T 439
Query: 277 ALHYAAK 283
LH AA+
Sbjct: 440 PLHMAAR 446
Score = 87.4 bits (215), Expect = 1e-17
Identities = 69/235 (29%), Positives = 109/235 (46%), Gaps = 4/235 (1%)
Query: 25 ELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHR 84
E +A+ C G T LH AA++G V L E A ++ PLH A +
Sbjct: 524 EKEASQACMTKKGFTPLHVAAKYGKVRVAELLLER-DAHPNAAGKNGLTPLHVAVHHNNL 582
Query: 85 DCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIA 144
D V+ LL RG + +TPL +A + + V + L+++G + ++ G H+A
Sbjct: 583 DIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA 642
Query: 145 SREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNC 204
++EG ++ LL+ +K TPLH A GH+ VL+K D
Sbjct: 643 AQEGHAEMVALLLSKQANG-NLGNKSGLTPLHLVAQEGHVPVADVLIKH-GVMVDATTRM 700
Query: 205 GVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLV 259
G T L A G+I + + LL +H A ++A+ LG LH+AA G + + L+
Sbjct: 701 GYTPLHVASHYGNIKLVKFLL-QHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754
Score = 78.6 bits (192), Expect = 6e-15
Identities = 66/219 (30%), Positives = 102/219 (46%), Gaps = 8/219 (3%)
Query: 14 VQEGRLRALKEELQAAGGCPGPA--GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDY 71
V L +K L G PA G T LH AA+ +V L + +G A +
Sbjct: 577 VHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ-YGGSANAESVQG 635
Query: 72 KRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPL 131
PLH AA GH + V LL + A + K+ TPL + ++ V L++HG
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695
Query: 132 LKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLL 191
+ G+ H+AS G+ ++++LL ++K+ +PLH AA GH + V +LL
Sbjct: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADV-NAKTKLGYSPLHQAAQQGHTDIVTLLL 754
Query: 192 KRCQYEPDYRDNCGVTALMDAIQCGHI---DVARLLLDE 227
K P+ + G T L A + G+I DV +++ DE
Sbjct: 755 KN-GASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDE 792
Score = 48.9 bits (115), Expect = 6e-06
Identities = 48/172 (27%), Positives = 77/172 (44%), Gaps = 4/172 (2%)
Query: 106 TPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWK 165
T + A NL + + +G + N++G N H+AS+EG ++ LL +
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK-EIILE 72
Query: 166 TESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLL 225
T +K T LH AA+ G E V+ L+ + + G T L A Q H++V + LL
Sbjct: 73 TTTKKGNTALHIAALAGQDEVVRELV-NYGANVNAQSQKGFTPLYMAAQENHLEVVKFLL 131
Query: 226 DEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTA 277
E+GA + G L A G + + L++ G VR + H+ A
Sbjct: 132 -ENGANQNVATEDGFTPLAVALQQGHENVVAHLIN-YGTKGKVRLPALHIAA 181
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 100 bits (250), Expect = 1e-21
Identities = 84/246 (34%), Positives = 127/246 (51%), Gaps = 8/246 (3%)
Query: 39 TLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVD 98
T LHCAAR+GH + L + G I+A ++ P+H AA H DCVR LL A +D
Sbjct: 274 TPLHCAARNGHVRISEILLDH-GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332
Query: 99 CLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLL- 157
+ TPL +A + V + L++ GA P + +G+ HIA ++ +++ LL
Sbjct: 333 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 392
Query: 158 TVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGH 217
T TES + TPLH A+ GHL VK LL+R P+ + T L A + GH
Sbjct: 393 TGASIDAVTESGL--TPLHVASFMGHLPIVKNLLQR-GASPNVSNVKVETPLHMAARAGH 449
Query: 218 IDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTA 277
+VA+ LL ++ A ++A+ LH AA G ++ L+ E + ++ T+ H T
Sbjct: 450 TEVAKYLL-QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL-ENNANPNLATTAGH-TP 506
Query: 278 LHYAAK 283
LH AA+
Sbjct: 507 LHIAAR 512
Score = 97.1 bits (240), Expect = 2e-20
Identities = 83/250 (33%), Positives = 119/250 (47%), Gaps = 10/250 (4%)
Query: 36 AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
+G T LH A+ GH ++ L + G +N + PLH AA GH + +YLL A
Sbjct: 403 SGLTPLHVASFMGHLPIVKNLLQR-GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461
Query: 96 AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGD-PLILQ 154
V+ K D TPL A + +++ L+E+ ANP L G HIA+REG +L
Sbjct: 462 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLA 521
Query: 155 YLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQ 214
L A T+ TPLH AA +G + ++LL+R P+ G+T L A+
Sbjct: 522 LLEKEASQACMTKKGF--TPLHVAAKYGKVRVAELLLER-DAHPNAAGKNGLTPLHVAVH 578
Query: 215 CGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTH 274
++D+ +LLL G+ S + G LH AA Q E R L+ G A S
Sbjct: 579 HNNLDIVKLLLPRGGSPHSPAWN-GYTPLHIAAKQNQVEVARSLLQYGG---SANAESVQ 634
Query: 275 -LTALHYAAK 283
+T LH AA+
Sbjct: 635 GVTPLHLAAQ 644
Score = 96.7 bits (239), Expect = 2e-20
Identities = 74/243 (30%), Positives = 121/243 (49%), Gaps = 10/243 (4%)
Query: 41 LHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCL 100
LH A++ GH ++ L + +E T + LH AA G + VR L+ GA V+
Sbjct: 49 LHLASKEGHVKMVVELLHK-EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQ 107
Query: 101 KKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVC 160
+ +TPL MA +L V++ L+E+GAN + +DG+ +A ++G ++ +L+
Sbjct: 108 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLIN-- 165
Query: 161 PGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDV 220
+ T+ K+R LH AA + VLL+ PD G T L A +++V
Sbjct: 166 ---YGTKGKVRLPALHIAARNDDTRTAAVLLQN-DPNPDVLSKTGFTPLHIAAHYENLNV 221
Query: 221 ARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHY 280
A+LLL+ GA ++ G LH A+ G +R L+ + G ++ + T LT LH
Sbjct: 222 AQLLLN-RGASVNFTPQNGITPLHIASRRGNVIMVRLLL-DRGAQIETK-TKDELTPLHC 278
Query: 281 AAK 283
AA+
Sbjct: 279 AAR 281
Score = 88.2 bits (217), Expect = 8e-18
Identities = 80/247 (32%), Positives = 117/247 (47%), Gaps = 6/247 (2%)
Query: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
G T LH AA + + +V L G + T ++ PLH A+ G+ VR LL RGA
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNR-GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264
Query: 97 VDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYL 156
++ K + TPL A ++ + + L++HGA K K+G + H+A+ +GD L L
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAA-QGDHLDCVRL 323
Query: 157 LTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCG 216
L + TPLH AA GH KVLL + +P+ R G T L A +
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK-GAKPNSRALNGFTPLHIACKKN 382
Query: 217 HIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLT 276
H+ V LLL + GA + A G LH A+ G ++ L+ + G +V T
Sbjct: 383 HVRVMELLL-KTGASIDAVTESGLTPLHVASFMGHLPIVKNLL-QRGASPNVSNVKVE-T 439
Query: 277 ALHYAAK 283
LH AA+
Sbjct: 440 PLHMAAR 446
Score = 87.4 bits (215), Expect = 1e-17
Identities = 69/235 (29%), Positives = 109/235 (46%), Gaps = 4/235 (1%)
Query: 25 ELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHR 84
E +A+ C G T LH AA++G V L E A ++ PLH A +
Sbjct: 524 EKEASQACMTKKGFTPLHVAAKYGKVRVAELLLER-DAHPNAAGKNGLTPLHVAVHHNNL 582
Query: 85 DCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIA 144
D V+ LL RG + +TPL +A + + V + L+++G + ++ G H+A
Sbjct: 583 DIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA 642
Query: 145 SREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNC 204
++EG ++ LL+ +K TPLH A GH+ VL+K D
Sbjct: 643 AQEGHAEMVALLLSKQANG-NLGNKSGLTPLHLVAQEGHVPVADVLIKH-GVMVDATTRM 700
Query: 205 GVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLV 259
G T L A G+I + + LL +H A ++A+ LG LH+AA G + + L+
Sbjct: 701 GYTPLHVASHYGNIKLVKFLL-QHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754
Score = 78.6 bits (192), Expect = 6e-15
Identities = 66/219 (30%), Positives = 102/219 (46%), Gaps = 8/219 (3%)
Query: 14 VQEGRLRALKEELQAAGGCPGPA--GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDY 71
V L +K L G PA G T LH AA+ +V L + +G A +
Sbjct: 577 VHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ-YGGSANAESVQG 635
Query: 72 KRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPL 131
PLH AA GH + V LL + A + K+ TPL + ++ V L++HG
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695
Query: 132 LKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLL 191
+ G+ H+AS G+ ++++LL ++K+ +PLH AA GH + V +LL
Sbjct: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADV-NAKTKLGYSPLHQAAQQGHTDIVTLLL 754
Query: 192 KRCQYEPDYRDNCGVTALMDAIQCGHI---DVARLLLDE 227
K P+ + G T L A + G+I DV +++ DE
Sbjct: 755 KN-GASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDE 792
Score = 48.9 bits (115), Expect = 6e-06
Identities = 48/172 (27%), Positives = 77/172 (44%), Gaps = 4/172 (2%)
Query: 106 TPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWK 165
T + A NL + + +G + N++G N H+AS+EG ++ LL +
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK-EIILE 72
Query: 166 TESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLL 225
T +K T LH AA+ G E V+ L+ + + G T L A Q H++V + LL
Sbjct: 73 TTTKKGNTALHIAALAGQDEVVRELV-NYGANVNAQSQKGFTPLYMAAQENHLEVVKFLL 131
Query: 226 DEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTA 277
E+GA + G L A G + + L++ G VR + H+ A
Sbjct: 132 -ENGANQNVATEDGFTPLAVALQQGHENVVAHLIN-YGTKGKVRLPALHIAA 181
>gi|110431370 espin [Homo sapiens]
Length = 854
Score = 100 bits (250), Expect = 1e-21
Identities = 85/275 (30%), Positives = 128/275 (46%), Gaps = 10/275 (3%)
Query: 15 QEGRLRALKEELQAAGGCPGPAGDTL----LHCAARHGHRDVLAYLAEAWGMDIEATNRD 70
++G L L+ L AAG D L +H AAR G L +L E + A R+
Sbjct: 11 RQGELDVLRS-LHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARARN 69
Query: 71 YKRPLHEAASMGHRDCVRYLLGRGAA-VDCLKKADWTPLMMACTRKNLGVIQELVEHGA- 128
P H+A++ GH C+++LL +G V + T L +A + V+ L+ HG
Sbjct: 70 GATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGG 129
Query: 129 NPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVK 188
+P G H A+ +GD L+ L+ P ++K TPL+ A GHLE +
Sbjct: 130 DPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQ 189
Query: 189 VLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAV 248
L++ C +P R + G+T L A Q GH V L+ LS +D GA A+H AA
Sbjct: 190 YLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAAS 249
Query: 249 TGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAK 283
G + + +L+ G ++ A T LH AA+
Sbjct: 250 RGHTKVLSWLLLHGG---EISADLWGGTPLHDAAE 281
Score = 68.9 bits (167), Expect = 5e-12
Identities = 68/237 (28%), Positives = 98/237 (41%), Gaps = 39/237 (16%)
Query: 26 LQAAGGC----PGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASM 81
L + GGC +G T+LH AAR GH +V+ +L G D A P+H AA+
Sbjct: 89 LLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAK 148
Query: 82 GHRDCVRYLLGR-GAAVDCLKKADWTPLMMACTRKNLGVIQELVEH-GANPLLKNKDGWN 139
G +R L+ V+ K TPL +AC +L V Q LV+ GA+P + DG
Sbjct: 149 GDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMT 208
Query: 140 SFHIASREGDPLILQYLLTVCPGAWKTESKIRRT-------------------------- 173
H A++ G ++ +L++ + + K T
Sbjct: 209 PLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISA 268
Query: 174 ------PLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLL 224
PLH AA +G LE ++L+ E D RD G TA + GH R L
Sbjct: 269 DLWGGTPLHDAAENGELECCQILVVN-GAELDVRDRDGYTAADLSDFNGHSHCTRYL 324
Score = 60.5 bits (145), Expect = 2e-09
Identities = 47/151 (31%), Positives = 70/151 (46%), Gaps = 10/151 (6%)
Query: 15 QEGRLRALKEELQAAGGCPGPA---GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDY 71
QEG L + +Q G P G T LH AA+ GH V+ +L + + ++D
Sbjct: 181 QEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDG 240
Query: 72 KRPLHEAASMGHRDCVRYLLGRGAAVDCLKKAD-W--TPLMMACTRKNLGVIQELVEHGA 128
+H AAS GH + +LL G + AD W TPL A L Q LV +GA
Sbjct: 241 ATAMHFAASRGHTKVLSWLLLHGGEIS----ADLWGGTPLHDAAENGELECCQILVVNGA 296
Query: 129 NPLLKNKDGWNSFHIASREGDPLILQYLLTV 159
++++DG+ + ++ G +YL TV
Sbjct: 297 ELDVRDRDGYTAADLSDFNGHSHCTRYLRTV 327
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 99.0 bits (245), Expect = 5e-21
Identities = 84/276 (30%), Positives = 126/276 (45%), Gaps = 32/276 (11%)
Query: 5 GDPRRLCRLVQEGRLRALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDI 64
GD R+ RLV + A AG P LH AA G +DV+ +L + G ++
Sbjct: 193 GDVSRVKRLVDAANVNAK----DMAGRKSSP-----LHFAAGFGRKDVVEHLLQM-GANV 242
Query: 65 EATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELV 124
A + PLH A S GH + V LL +GA + ++TPL A + + V L+
Sbjct: 243 HARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLL 302
Query: 125 EHGANPLLKNKDGWNSFHI--------------------ASREGDPLILQYLLTVCPGAW 164
+HGA+P ++N DG ++ + A+R G+ L LLT
Sbjct: 303 QHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNC 362
Query: 165 KTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLL 224
+ TPLH AA + + V++LL+ + +D G+ L +A GH +V LL
Sbjct: 363 HASDGRKSTPLHLAAGYNRVRIVQLLLQH-GADVHAKDKGGLVPLHNACSYGHYEVTELL 421
Query: 225 LDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVS 260
L +HGAC++A D LH AA + E L+S
Sbjct: 422 L-KHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLS 456
Score = 89.7 bits (221), Expect = 3e-18
Identities = 70/242 (28%), Positives = 110/242 (45%), Gaps = 23/242 (9%)
Query: 39 TLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVD 98
T LH AA + V+ YL G D+ A ++ PLH A S GH + L+ GA+V+
Sbjct: 686 TPLHFAAGYNRVSVVEYLLHH-GADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVN 744
Query: 99 CLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASR---------EGD 149
+TPL A + + + L++HGA+P KN+DG + GD
Sbjct: 745 VADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGD 804
Query: 150 PLILQYLLTVCPGAWK---TESKIR--------RTPLHTAAMHGHLEAVKVLLKRCQYEP 198
+L C + T I TPLH AA + +LE + LL+ +
Sbjct: 805 AALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGA-DV 863
Query: 199 DYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFL 258
+ +D G+ L +A GH+D+A LL+ ++ C++A D LH AA G+ + L
Sbjct: 864 NAQDKGGLIPLHNAASYGHVDIAALLI-KYNTCVNATDKWAFTPLHEAAQKGRTQLCALL 922
Query: 259 VS 260
++
Sbjct: 923 LA 924
Score = 84.3 bits (207), Expect = 1e-16
Identities = 78/268 (29%), Positives = 121/268 (45%), Gaps = 26/268 (9%)
Query: 16 EGRLRALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPL 75
E +L AL L T LH AA + ++ L + G D+ A ++ PL
Sbjct: 348 EEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQH-GADVHAKDKGGLVPL 406
Query: 76 HEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNK 135
H A S GH + LL GA V+ + +TPL A ++ + V L+ HGA+P L N
Sbjct: 407 HNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNC 466
Query: 136 DGWNSFHI---------------------ASREGDPLILQYLLTVCPGAWKTESKIRRTP 174
G ++ + A+RE D ++ L + +K + + T
Sbjct: 467 HGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFK-QPQSHETA 525
Query: 175 LH--TAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACL 232
LH A++H + V LL R + ++ +T L A + H DV +L +HGA +
Sbjct: 526 LHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVME-VLHKHGAKM 584
Query: 233 SAEDSLGAQALHRAAVTGQDEAIRFLVS 260
+A D+LG ALHRAA+ G + R L+S
Sbjct: 585 NALDTLGQTALHRAALAGHLQTCRLLLS 612
Score = 73.9 bits (180), Expect = 2e-13
Identities = 65/250 (26%), Positives = 104/250 (41%), Gaps = 30/250 (12%)
Query: 38 DTLLHCAAR--HGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
+T LHCA H R + L G ++ N+D+ PLH AA H D + L GA
Sbjct: 523 ETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGA 582
Query: 96 AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHI------------ 143
++ L T L A +L + L+ +G++P + + G+ + +
Sbjct: 583 KMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSES 642
Query: 144 --------------ASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKV 189
AS+ GD ++ L + + TPLH AA + + V+
Sbjct: 643 TPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEY 702
Query: 190 LLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVT 249
LL + +D G+ L +A GH +VA LL+ HGA ++ D LH AA
Sbjct: 703 LLHH-GADVHAKDKGGLVPLHNACSYGHYEVAELLV-RHGASVNVADLWKFTPLHEAAAK 760
Query: 250 GQDEAIRFLV 259
G+ E + L+
Sbjct: 761 GKYEICKLLL 770
Score = 62.0 bits (149), Expect = 6e-10
Identities = 37/109 (33%), Positives = 56/109 (51%), Gaps = 1/109 (0%)
Query: 39 TLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVD 98
T LH AA + + +V YL E G D+ A ++ PLH AAS GH D L+ V+
Sbjct: 839 TPLHLAAGYNNLEVAEYLLEH-GADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVN 897
Query: 99 CLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASRE 147
K +TPL A + + L+ HGA+P +KN++G +A+ +
Sbjct: 898 ATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATAD 946
Score = 37.0 bits (84), Expect = 0.022
Identities = 30/121 (24%), Positives = 50/121 (41%)
Query: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
GD L AA+ G + L ++ T PLH AA + + YLL GA
Sbjct: 803 GDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGAD 862
Query: 97 VDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYL 156
V+ K PL A + ++ + L+++ +K + H A+++G + L
Sbjct: 863 VNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALL 922
Query: 157 L 157
L
Sbjct: 923 L 923
>gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Homo
sapiens]
Length = 587
Score = 97.8 bits (242), Expect = 1e-20
Identities = 88/286 (30%), Positives = 129/286 (45%), Gaps = 18/286 (6%)
Query: 4 PGDPRRLCRLVQEGRLRALKEELQAAGGC--PGPAGDTLLHCAARHGHRDVLAYLAEAWG 61
P DP L + +++G ALK ++ P G LH AA +G L L A+
Sbjct: 57 PADP--LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYP 114
Query: 62 MDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQ 121
I+ + ++ A GH DC+ LL GA D K+ TPL AC RKN ++
Sbjct: 115 GTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVK 174
Query: 122 ELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESK--IRRTPLHTAA 179
LV+H A+ + GW + H + D ++Q L++ G K ESK TPL AA
Sbjct: 175 ILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVS---GGAKVESKNAYGITPLFVAA 231
Query: 180 MHGHLEAVKVLLKRCQYEPDYRDNC--GVTALMDAIQCGHIDVARLLLDEHGACLSAEDS 237
G LEA++ L K Y D +AL +A + H +V LL + GA + +
Sbjct: 232 QSGQLEALRFLAK---YGADINTQASDNASALYEACKNEHEEVVEFLLSQ-GADANKTNK 287
Query: 238 LGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAK 283
G LH A+ G ++ L L V R + ++ LH AA+
Sbjct: 288 DGLLPLHIASKKGNYRIVQML---LPVTSRTRIRRSGVSPLHLAAE 330
Score = 69.7 bits (169), Expect = 3e-12
Identities = 63/209 (30%), Positives = 98/209 (46%), Gaps = 26/209 (12%)
Query: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
G T LH + +V+ L G +E+ N PL AA G + +R+L GA
Sbjct: 190 GWTALHESVSRNDLEVMQILVSG-GAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGAD 248
Query: 97 VDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYL 156
++ + + L AC ++ V++ L+ GA+ NKDG HIAS++G+ I+Q L
Sbjct: 249 INTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQML 308
Query: 157 LTVCPGAWKTESKIRRT---PLHTAAMHGHLEAVKVLL------------KRCQYEPDYR 201
L V + ++IRR+ PLH AA H E ++ LL +R + D R
Sbjct: 309 LPVT-----SRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRR 363
Query: 202 DNCGVTALMDAIQCGHIDVARLLLDEHGA 230
+AL A+ ++ LLL +HGA
Sbjct: 364 S----SALYFAVVNNNVYATELLL-QHGA 387
Score = 33.1 bits (74), Expect = 0.31
Identities = 45/186 (24%), Positives = 71/186 (38%), Gaps = 47/186 (25%)
Query: 15 QEGRLRALKEELQAAGGCPGPAGD--TLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYK 72
Q G+L AL+ + A D + L+ A ++ H +V+ +L G D TN+D
Sbjct: 232 QSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQ-GADANKTNKDGL 290
Query: 73 RPLHEAASMGHRDCVRYLL----------------------GRGAAVDCLKKADW---TP 107
PLH A+ G+ V+ LL ++ L A + TP
Sbjct: 291 LPLHIASKKGNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTP 350
Query: 108 LM----------------MACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPL 151
L A N+ + L++HGA+P N+D + +A R G
Sbjct: 351 LAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGADP---NRDVISPLLVAIRHGCLR 407
Query: 152 ILQYLL 157
+Q LL
Sbjct: 408 TMQLLL 413
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 97.1 bits (240), Expect = 2e-20
Identities = 82/248 (33%), Positives = 114/248 (45%), Gaps = 10/248 (4%)
Query: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
G T LH A R V+ L A + + A + D LH AA G R LL + A+
Sbjct: 471 GSTPLHMAVERRVRGVVELLL-ARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNAS 529
Query: 97 VDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYL 156
V+ + TP+ +AC +++ L+ G + L+ KD W H A+ +G I++ L
Sbjct: 530 VNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVK-L 588
Query: 157 LTVCPG-AWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQC 215
L PG + ++ RTPLH AA GH ++L+ C + + T L A +
Sbjct: 589 LAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCS-DVNVCSLLAQTPLHVAAET 647
Query: 216 GHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRA----T 271
GH ARLLL GA A S G ALH AA G ++ LV E DV R T
Sbjct: 648 GHTSTARLLL-HRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEE-KADVLARGPLNQT 705
Query: 272 STHLTALH 279
+ HL A H
Sbjct: 706 ALHLAAAH 713
Score = 95.1 bits (235), Expect = 7e-20
Identities = 77/246 (31%), Positives = 114/246 (46%), Gaps = 8/246 (3%)
Query: 39 TLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVD 98
T LH AA++G L E + + + + P+H A G + VR LL RG V
Sbjct: 506 TALHFAAQNGDESSTRLLLEK-NASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVS 564
Query: 99 CLKKADWTPLMMACTRKNLGVIQELVEH-GANPLLKNKDGWNSFHIASREGDPLILQYLL 157
K W PL A + +L +++ L + G + + DG H+A++ G + + L+
Sbjct: 565 LQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILI 624
Query: 158 TVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGH 217
+C S + +TPLH AA GH ++LL R + + G TAL A + GH
Sbjct: 625 DLCSDV-NVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSD-GYTALHLAARNGH 682
Query: 218 IDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTA 277
+ +LL++E L A L ALH AA G E + LVS DV L+A
Sbjct: 683 LATVKLLVEEKADVL-ARGPLNQTALHLAAAHGHSEVVEELVS---ADVIDLFDEQGLSA 738
Query: 278 LHYAAK 283
LH AA+
Sbjct: 739 LHLAAQ 744
Score = 83.2 bits (204), Expect = 3e-16
Identities = 62/209 (29%), Positives = 99/209 (47%), Gaps = 4/209 (1%)
Query: 75 LHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKN 134
LH A G +C ++LL A + + TPL MA R+ GV++ L+ + K+
Sbjct: 442 LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD 501
Query: 135 KDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRC 194
+D W + H A++ GD + LL + + + RTP+H A HG V++LL+R
Sbjct: 502 EDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFE-GRTPMHVACQHGQENIVRILLRR- 559
Query: 195 QYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEA 254
+ + L A GH+ + +LL + G ++A+ G LH AA G
Sbjct: 560 GVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRV 619
Query: 255 IRFLVSELGVDVDVRATSTHLTALHYAAK 283
R L+ +L DV+V + T LH AA+
Sbjct: 620 ARILI-DLCSDVNVCSLLAQ-TPLHVAAE 646
Score = 82.4 bits (202), Expect = 4e-16
Identities = 67/209 (32%), Positives = 93/209 (44%), Gaps = 5/209 (2%)
Query: 41 LHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCL 100
LH AA GH ++ LA+ G+ + A D + PLH AA GH R L+ + V+
Sbjct: 574 LHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVC 633
Query: 101 KKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVC 160
TPL +A + + L+ GA DG+ + H+A+R G L LL
Sbjct: 634 SLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGH-LATVKLLVEE 692
Query: 161 PGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDV 220
+ +T LH AA HGH E V+ L+ D D G++AL A Q H
Sbjct: 693 KADVLARGPLNQTALHLAAAHGHSEVVEELVSADVI--DLFDEQGLSALHLAAQGRHAQT 750
Query: 221 ARLLLDEHGACLSAEDSLGAQALHRAAVT 249
LL HGA ++ + SL Q H A T
Sbjct: 751 VETLL-RHGAHINLQ-SLKFQGGHGPAAT 777
Score = 37.7 bits (86), Expect = 0.013
Identities = 24/65 (36%), Positives = 31/65 (47%), Gaps = 2/65 (3%)
Query: 34 GPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGR 93
GP T LH AA HGH +V+ L A +D+ + LH AA H V LL
Sbjct: 700 GPLNQTALHLAAAHGHSEVVEELVSADVIDL--FDEQGLSALHLAAQGRHAQTVETLLRH 757
Query: 94 GAAVD 98
GA ++
Sbjct: 758 GAHIN 762
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 96.3 bits (238), Expect = 3e-20
Identities = 82/248 (33%), Positives = 121/248 (48%), Gaps = 6/248 (2%)
Query: 36 AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
+G T +H AA GH +++ L + G + TN + LH AA G + VR LL GA
Sbjct: 409 SGLTPIHVAAFMGHLNIVLLLLQN-GASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA 467
Query: 96 AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQY 155
VD + + TPL +A ++Q L++H A+P +G+ HI++REG +
Sbjct: 468 LVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASV 527
Query: 156 LLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQC 215
LL A +K TPLH AA +G L+ K+LL+R + D G+T L A
Sbjct: 528 LLE-AGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQR-RAAADSAGKNGLTPLHVAAHY 585
Query: 216 GHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHL 275
+ VA LLL E GA A G LH AA Q + L++ G + ++ T +
Sbjct: 586 DNQKVALLLL-EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN-YGAETNI-VTKQGV 642
Query: 276 TALHYAAK 283
T LH A++
Sbjct: 643 TPLHLASQ 650
Score = 88.6 bits (218), Expect = 6e-18
Identities = 74/222 (33%), Positives = 108/222 (48%), Gaps = 7/222 (3%)
Query: 62 MDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQ 121
M + T PLH AA G+ + LL RGAAVD + TPL +A R N +++
Sbjct: 203 MMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVK 262
Query: 122 ELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLL-TVCPGAWKTESKIRRTPLHTAAM 180
L++ G K +DG H A+R G +++ LL P +T++ + +PLH AA
Sbjct: 263 LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGL--SPLHMAAQ 320
Query: 181 HGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGA 240
H+E VK LL+ D + +TAL A CGH V +LLLD+ A +A G
Sbjct: 321 GDHVECVKHLLQHKAPVDDVTLDY-LTALHVAAHCGHYRVTKLLLDKR-ANPNARALNGF 378
Query: 241 QALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAA 282
LH A + + + LV + G + T + LT +H AA
Sbjct: 379 TPLHIACKKNRIKVMELLV-KYGASIQA-ITESGLTPIHVAA 418
Score = 86.3 bits (212), Expect = 3e-17
Identities = 79/249 (31%), Positives = 119/249 (47%), Gaps = 8/249 (3%)
Query: 36 AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
+G T LH AA +G+ +V L G ++ T R+ PLH A+ G+ + V+ LL RG
Sbjct: 211 SGFTPLHIAAHYGNVNVATLLLNR-GAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGG 269
Query: 96 AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQY 155
+D + TPL A + V++ L+E GA L + K+G + H+A++ +++
Sbjct: 270 QIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKH 329
Query: 156 LLT-VCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQ 214
LL P T + T LH AA GH K+LL + + P+ R G T L A +
Sbjct: 330 LLQHKAPVDDVTLDYL--TALHVAAHCGHYRVTKLLLDK-RANPNARALNGFTPLHIACK 386
Query: 215 CGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTH 274
I V LL+ ++GA + A G +H AA G + L+ G DV
Sbjct: 387 KNRIKVMELLV-KYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQN-GASPDVTNIRGE 444
Query: 275 LTALHYAAK 283
TALH AA+
Sbjct: 445 -TALHMAAR 452
Score = 85.1 bits (209), Expect = 7e-17
Identities = 82/249 (32%), Positives = 113/249 (45%), Gaps = 10/249 (4%)
Query: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
G T LH A + V+ L + +G I+A P+H AA MGH + V LL GA+
Sbjct: 377 GFTPLHIACKKNRIKVMELLVK-YGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGAS 435
Query: 97 VDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYL 156
D T L MA + V++ L+ +GA + ++ HIASR G I+Q L
Sbjct: 436 PDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL 495
Query: 157 L--TVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQ 214
L P A T TPLH +A G ++ VLL+ G T L A +
Sbjct: 496 LQHMAHPDAATTNG---YTPLHISAREGQVDVASVLLE-AGAAHSLATKKGFTPLHVAAK 551
Query: 215 CGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTH 274
G +DVA+LLL A SA + G LH AA ++ + L+ E G A + +
Sbjct: 552 YGSLDVAKLLLQRRAAADSAGKN-GLTPLHVAA-HYDNQKVALLLLEKGASPHATAKNGY 609
Query: 275 LTALHYAAK 283
T LH AAK
Sbjct: 610 -TPLHIAAK 617
Score = 85.1 bits (209), Expect = 7e-17
Identities = 77/253 (30%), Positives = 116/253 (45%), Gaps = 7/253 (2%)
Query: 27 QAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDC 86
+AA G G T LH AA + ++ V L E G AT ++ PLH AA
Sbjct: 565 RAAADSAGKNGLTPLHVAAHYDNQKVALLLLEK-GASPHATAKNGYTPLHIAAKKNQMQI 623
Query: 87 VRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASR 146
LL GA + + K TPL +A + ++ L++ GAN + K G S H+A++
Sbjct: 624 ASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQ 683
Query: 147 EGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGV 206
E D + + +LT +K+ TPL A +G+++ V LLK+ + + G
Sbjct: 684 E-DKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ-GANVNAKTKNGY 741
Query: 207 TALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDV 266
T L A Q GH + +LL +HGA +A + G AL A G + L V
Sbjct: 742 TPLHQAAQQGHTHIINVLL-QHGAKPNATTANGNTALAIAKRLGYISVVDTLKV---VTE 797
Query: 267 DVRATSTHLTALH 279
+V T+T +T H
Sbjct: 798 EVTTTTTTITEKH 810
Score = 81.6 bits (200), Expect = 8e-16
Identities = 83/278 (29%), Positives = 128/278 (46%), Gaps = 45/278 (16%)
Query: 44 AARHGHRD-VLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKK 102
AAR G+ D V+ YL G+DI N++ LH AA GH V+ LLGRG++VD K
Sbjct: 17 AARAGNLDKVVEYLKG--GIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK 74
Query: 103 ADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPG 162
T L +A V++ LV+ GAN ++++G+ ++A++E +++YLL G
Sbjct: 75 KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE--NG 132
Query: 163 A-WKTESKIRRTPLHTAAMHGHLEAVKVLLK----------------------------R 193
A T ++ TPL A GH +AV +LL+ +
Sbjct: 133 ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 192
Query: 194 CQYEPDYRD--------NCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHR 245
+ D + G T L A G+++VA LLL+ GA + G LH
Sbjct: 193 NDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLN-RGAAVDFTARNGITPLHV 251
Query: 246 AAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAK 283
A+ G ++ L+ + G +D + T LT LH AA+
Sbjct: 252 ASKRGNTNMVKLLL-DRGGQIDAK-TRDGLTPLHCAAR 287
Score = 61.2 bits (147), Expect = 1e-09
Identities = 59/185 (31%), Positives = 88/185 (47%), Gaps = 10/185 (5%)
Query: 100 LKKADWTPLMMACTRK-NLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLT 158
L+K+D + R NL + E ++ G + N++G N+ H+A++EG ++Q LL
Sbjct: 5 LQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG 64
Query: 159 VCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHI 218
+ + +K T LH A++ G E VKVL+K N G T L A Q HI
Sbjct: 65 -RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQN-GFTPLYMAAQENHI 122
Query: 219 DVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTAL 278
DV + LL E+GA S G L A G ++A+ L+ D + L AL
Sbjct: 123 DVVKYLL-ENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN-----DTKG-KVRLPAL 175
Query: 279 HYAAK 283
H AA+
Sbjct: 176 HIAAR 180
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 96.3 bits (238), Expect = 3e-20
Identities = 82/248 (33%), Positives = 121/248 (48%), Gaps = 6/248 (2%)
Query: 36 AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
+G T +H AA GH +++ L + G + TN + LH AA G + VR LL GA
Sbjct: 430 SGLTPIHVAAFMGHLNIVLLLLQN-GASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA 488
Query: 96 AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQY 155
VD + + TPL +A ++Q L++H A+P +G+ HI++REG +
Sbjct: 489 LVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASV 548
Query: 156 LLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQC 215
LL A +K TPLH AA +G L+ K+LL+R + D G+T L A
Sbjct: 549 LLE-AGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQR-RAAADSAGKNGLTPLHVAAHY 606
Query: 216 GHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHL 275
+ VA LLL E GA A G LH AA Q + L++ G + ++ T +
Sbjct: 607 DNQKVALLLL-EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN-YGAETNI-VTKQGV 663
Query: 276 TALHYAAK 283
T LH A++
Sbjct: 664 TPLHLASQ 671
Score = 88.6 bits (218), Expect = 6e-18
Identities = 74/222 (33%), Positives = 108/222 (48%), Gaps = 7/222 (3%)
Query: 62 MDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQ 121
M + T PLH AA G+ + LL RGAAVD + TPL +A R N +++
Sbjct: 224 MMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVK 283
Query: 122 ELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLL-TVCPGAWKTESKIRRTPLHTAAM 180
L++ G K +DG H A+R G +++ LL P +T++ + +PLH AA
Sbjct: 284 LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGL--SPLHMAAQ 341
Query: 181 HGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGA 240
H+E VK LL+ D + +TAL A CGH V +LLLD+ A +A G
Sbjct: 342 GDHVECVKHLLQHKAPVDDVTLDY-LTALHVAAHCGHYRVTKLLLDKR-ANPNARALNGF 399
Query: 241 QALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAA 282
LH A + + + LV + G + T + LT +H AA
Sbjct: 400 TPLHIACKKNRIKVMELLV-KYGASIQA-ITESGLTPIHVAA 439
Score = 86.3 bits (212), Expect = 3e-17
Identities = 79/249 (31%), Positives = 119/249 (47%), Gaps = 8/249 (3%)
Query: 36 AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
+G T LH AA +G+ +V L G ++ T R+ PLH A+ G+ + V+ LL RG
Sbjct: 232 SGFTPLHIAAHYGNVNVATLLLNR-GAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGG 290
Query: 96 AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQY 155
+D + TPL A + V++ L+E GA L + K+G + H+A++ +++
Sbjct: 291 QIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKH 350
Query: 156 LLT-VCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQ 214
LL P T + T LH AA GH K+LL + + P+ R G T L A +
Sbjct: 351 LLQHKAPVDDVTLDYL--TALHVAAHCGHYRVTKLLLDK-RANPNARALNGFTPLHIACK 407
Query: 215 CGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTH 274
I V LL+ ++GA + A G +H AA G + L+ G DV
Sbjct: 408 KNRIKVMELLV-KYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQN-GASPDVTNIRGE 465
Query: 275 LTALHYAAK 283
TALH AA+
Sbjct: 466 -TALHMAAR 473
Score = 85.1 bits (209), Expect = 7e-17
Identities = 82/249 (32%), Positives = 113/249 (45%), Gaps = 10/249 (4%)
Query: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
G T LH A + V+ L + +G I+A P+H AA MGH + V LL GA+
Sbjct: 398 GFTPLHIACKKNRIKVMELLVK-YGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGAS 456
Query: 97 VDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYL 156
D T L MA + V++ L+ +GA + ++ HIASR G I+Q L
Sbjct: 457 PDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL 516
Query: 157 L--TVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQ 214
L P A T TPLH +A G ++ VLL+ G T L A +
Sbjct: 517 LQHMAHPDAATTNG---YTPLHISAREGQVDVASVLLE-AGAAHSLATKKGFTPLHVAAK 572
Query: 215 CGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTH 274
G +DVA+LLL A SA + G LH AA ++ + L+ E G A + +
Sbjct: 573 YGSLDVAKLLLQRRAAADSAGKN-GLTPLHVAA-HYDNQKVALLLLEKGASPHATAKNGY 630
Query: 275 LTALHYAAK 283
T LH AAK
Sbjct: 631 -TPLHIAAK 638
Score = 85.1 bits (209), Expect = 7e-17
Identities = 77/253 (30%), Positives = 116/253 (45%), Gaps = 7/253 (2%)
Query: 27 QAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDC 86
+AA G G T LH AA + ++ V L E G AT ++ PLH AA
Sbjct: 586 RAAADSAGKNGLTPLHVAAHYDNQKVALLLLEK-GASPHATAKNGYTPLHIAAKKNQMQI 644
Query: 87 VRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASR 146
LL GA + + K TPL +A + ++ L++ GAN + K G S H+A++
Sbjct: 645 ASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQ 704
Query: 147 EGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGV 206
E D + + +LT +K+ TPL A +G+++ V LLK+ + + G
Sbjct: 705 E-DKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ-GANVNAKTKNGY 762
Query: 207 TALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDV 266
T L A Q GH + +LL +HGA +A + G AL A G + L V
Sbjct: 763 TPLHQAAQQGHTHIINVLL-QHGAKPNATTANGNTALAIAKRLGYISVVDTLKV---VTE 818
Query: 267 DVRATSTHLTALH 279
+V T+T +T H
Sbjct: 819 EVTTTTTTITEKH 831
Score = 81.6 bits (200), Expect = 8e-16
Identities = 83/278 (29%), Positives = 128/278 (46%), Gaps = 45/278 (16%)
Query: 44 AARHGHRD-VLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKK 102
AAR G+ D V+ YL G+DI N++ LH AA GH V+ LLGRG++VD K
Sbjct: 38 AARAGNLDKVVEYLKG--GIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK 95
Query: 103 ADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPG 162
T L +A V++ LV+ GAN ++++G+ ++A++E +++YLL G
Sbjct: 96 KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE--NG 153
Query: 163 A-WKTESKIRRTPLHTAAMHGHLEAVKVLLK----------------------------R 193
A T ++ TPL A GH +AV +LL+ +
Sbjct: 154 ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 213
Query: 194 CQYEPDYRD--------NCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHR 245
+ D + G T L A G+++VA LLL+ GA + G LH
Sbjct: 214 NDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLN-RGAAVDFTARNGITPLHV 272
Query: 246 AAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAK 283
A+ G ++ L+ + G +D + T LT LH AA+
Sbjct: 273 ASKRGNTNMVKLLL-DRGGQIDAK-TRDGLTPLHCAAR 308
Score = 61.2 bits (147), Expect = 1e-09
Identities = 59/184 (32%), Positives = 87/184 (47%), Gaps = 10/184 (5%)
Query: 101 KKADWTPLMMACTRK-NLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTV 159
KK+D + R NL + E ++ G + N++G N+ H+A++EG ++Q LL
Sbjct: 27 KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG- 85
Query: 160 CPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHID 219
+ + +K T LH A++ G E VKVL+K N G T L A Q HID
Sbjct: 86 RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQN-GFTPLYMAAQENHID 144
Query: 220 VARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALH 279
V + LL E+GA S G L A G ++A+ L+ D + L ALH
Sbjct: 145 VVKYLL-ENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN-----DTKG-KVRLPALH 197
Query: 280 YAAK 283
AA+
Sbjct: 198 IAAR 201
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 96.3 bits (238), Expect = 3e-20
Identities = 82/248 (33%), Positives = 121/248 (48%), Gaps = 6/248 (2%)
Query: 36 AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
+G T +H AA GH +++ L + G + TN + LH AA G + VR LL GA
Sbjct: 430 SGLTPIHVAAFMGHLNIVLLLLQN-GASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA 488
Query: 96 AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQY 155
VD + + TPL +A ++Q L++H A+P +G+ HI++REG +
Sbjct: 489 LVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASV 548
Query: 156 LLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQC 215
LL A +K TPLH AA +G L+ K+LL+R + D G+T L A
Sbjct: 549 LLE-AGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQR-RAAADSAGKNGLTPLHVAAHY 606
Query: 216 GHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHL 275
+ VA LLL E GA A G LH AA Q + L++ G + ++ T +
Sbjct: 607 DNQKVALLLL-EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN-YGAETNI-VTKQGV 663
Query: 276 TALHYAAK 283
T LH A++
Sbjct: 664 TPLHLASQ 671
Score = 88.6 bits (218), Expect = 6e-18
Identities = 74/222 (33%), Positives = 108/222 (48%), Gaps = 7/222 (3%)
Query: 62 MDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQ 121
M + T PLH AA G+ + LL RGAAVD + TPL +A R N +++
Sbjct: 224 MMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVK 283
Query: 122 ELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLL-TVCPGAWKTESKIRRTPLHTAAM 180
L++ G K +DG H A+R G +++ LL P +T++ + +PLH AA
Sbjct: 284 LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGL--SPLHMAAQ 341
Query: 181 HGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGA 240
H+E VK LL+ D + +TAL A CGH V +LLLD+ A +A G
Sbjct: 342 GDHVECVKHLLQHKAPVDDVTLDY-LTALHVAAHCGHYRVTKLLLDKR-ANPNARALNGF 399
Query: 241 QALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAA 282
LH A + + + LV + G + T + LT +H AA
Sbjct: 400 TPLHIACKKNRIKVMELLV-KYGASIQA-ITESGLTPIHVAA 439
Score = 86.3 bits (212), Expect = 3e-17
Identities = 79/249 (31%), Positives = 119/249 (47%), Gaps = 8/249 (3%)
Query: 36 AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
+G T LH AA +G+ +V L G ++ T R+ PLH A+ G+ + V+ LL RG
Sbjct: 232 SGFTPLHIAAHYGNVNVATLLLNR-GAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGG 290
Query: 96 AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQY 155
+D + TPL A + V++ L+E GA L + K+G + H+A++ +++
Sbjct: 291 QIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKH 350
Query: 156 LLT-VCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQ 214
LL P T + T LH AA GH K+LL + + P+ R G T L A +
Sbjct: 351 LLQHKAPVDDVTLDYL--TALHVAAHCGHYRVTKLLLDK-RANPNARALNGFTPLHIACK 407
Query: 215 CGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTH 274
I V LL+ ++GA + A G +H AA G + L+ G DV
Sbjct: 408 KNRIKVMELLV-KYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQN-GASPDVTNIRGE 465
Query: 275 LTALHYAAK 283
TALH AA+
Sbjct: 466 -TALHMAAR 473
Score = 85.1 bits (209), Expect = 7e-17
Identities = 82/249 (32%), Positives = 113/249 (45%), Gaps = 10/249 (4%)
Query: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
G T LH A + V+ L + +G I+A P+H AA MGH + V LL GA+
Sbjct: 398 GFTPLHIACKKNRIKVMELLVK-YGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGAS 456
Query: 97 VDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYL 156
D T L MA + V++ L+ +GA + ++ HIASR G I+Q L
Sbjct: 457 PDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL 516
Query: 157 L--TVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQ 214
L P A T TPLH +A G ++ VLL+ G T L A +
Sbjct: 517 LQHMAHPDAATTNG---YTPLHISAREGQVDVASVLLE-AGAAHSLATKKGFTPLHVAAK 572
Query: 215 CGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTH 274
G +DVA+LLL A SA + G LH AA ++ + L+ E G A + +
Sbjct: 573 YGSLDVAKLLLQRRAAADSAGKN-GLTPLHVAA-HYDNQKVALLLLEKGASPHATAKNGY 630
Query: 275 LTALHYAAK 283
T LH AAK
Sbjct: 631 -TPLHIAAK 638
Score = 85.1 bits (209), Expect = 7e-17
Identities = 77/253 (30%), Positives = 116/253 (45%), Gaps = 7/253 (2%)
Query: 27 QAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDC 86
+AA G G T LH AA + ++ V L E G AT ++ PLH AA
Sbjct: 586 RAAADSAGKNGLTPLHVAAHYDNQKVALLLLEK-GASPHATAKNGYTPLHIAAKKNQMQI 644
Query: 87 VRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASR 146
LL GA + + K TPL +A + ++ L++ GAN + K G S H+A++
Sbjct: 645 ASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQ 704
Query: 147 EGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGV 206
E D + + +LT +K+ TPL A +G+++ V LLK+ + + G
Sbjct: 705 E-DKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ-GANVNAKTKNGY 762
Query: 207 TALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDV 266
T L A Q GH + +LL +HGA +A + G AL A G + L V
Sbjct: 763 TPLHQAAQQGHTHIINVLL-QHGAKPNATTANGNTALAIAKRLGYISVVDTLKV---VTE 818
Query: 267 DVRATSTHLTALH 279
+V T+T +T H
Sbjct: 819 EVTTTTTTITEKH 831
Score = 81.6 bits (200), Expect = 8e-16
Identities = 83/278 (29%), Positives = 128/278 (46%), Gaps = 45/278 (16%)
Query: 44 AARHGHRD-VLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKK 102
AAR G+ D V+ YL G+DI N++ LH AA GH V+ LLGRG++VD K
Sbjct: 38 AARAGNLDKVVEYLKG--GIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK 95
Query: 103 ADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPG 162
T L +A V++ LV+ GAN ++++G+ ++A++E +++YLL G
Sbjct: 96 KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE--NG 153
Query: 163 A-WKTESKIRRTPLHTAAMHGHLEAVKVLLK----------------------------R 193
A T ++ TPL A GH +AV +LL+ +
Sbjct: 154 ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 213
Query: 194 CQYEPDYRD--------NCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHR 245
+ D + G T L A G+++VA LLL+ GA + G LH
Sbjct: 214 NDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLN-RGAAVDFTARNGITPLHV 272
Query: 246 AAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAK 283
A+ G ++ L+ + G +D + T LT LH AA+
Sbjct: 273 ASKRGNTNMVKLLL-DRGGQIDAK-TRDGLTPLHCAAR 308
Score = 61.2 bits (147), Expect = 1e-09
Identities = 59/184 (32%), Positives = 87/184 (47%), Gaps = 10/184 (5%)
Query: 101 KKADWTPLMMACTRK-NLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTV 159
KK+D + R NL + E ++ G + N++G N+ H+A++EG ++Q LL
Sbjct: 27 KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG- 85
Query: 160 CPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHID 219
+ + +K T LH A++ G E VKVL+K N G T L A Q HID
Sbjct: 86 RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQN-GFTPLYMAAQENHID 144
Query: 220 VARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALH 279
V + LL E+GA S G L A G ++A+ L+ D + L ALH
Sbjct: 145 VVKYLL-ENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN-----DTKG-KVRLPALH 197
Query: 280 YAAK 283
AA+
Sbjct: 198 IAAR 201
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 95.9 bits (237), Expect = 4e-20
Identities = 73/242 (30%), Positives = 113/242 (46%), Gaps = 23/242 (9%)
Query: 39 TLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVD 98
T LH AA G +DV+ YL + G +++A + PLH A S GH + V LL GA +
Sbjct: 60 TPLHFAAGFGRKDVVEYLLQN-GANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPN 118
Query: 99 CLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIA-------------- 144
++TPL A + + V L++HGA P ++N DG + +A
Sbjct: 119 ARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKK 178
Query: 145 ------SREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEP 198
+R G+ + LLT + TPLH AA + ++ V++LL+ +
Sbjct: 179 DELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQH-GADV 237
Query: 199 DYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFL 258
+D + L +A GH +V LL+ +HGAC++A D LH AA + E L
Sbjct: 238 HAKDKGDLVPLHNACSYGHYEVTELLV-KHGACVNAMDLWQFTPLHEAASKNRVEVCSLL 296
Query: 259 VS 260
+S
Sbjct: 297 LS 298
Score = 93.2 bits (230), Expect = 3e-19
Identities = 72/242 (29%), Positives = 110/242 (45%), Gaps = 23/242 (9%)
Query: 39 TLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVD 98
T LH AA + V+ YL + G D+ A ++ PLH A S GH + L+ GA V+
Sbjct: 528 TPLHFAAGYNRVSVVEYLLQH-GADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVN 586
Query: 99 CLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIAS---------REGD 149
+TPL A + + + L++HGA+P KN+DG + GD
Sbjct: 587 VADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGD 646
Query: 150 PLILQYLLTVCPGAWKTESK-----------IRRTPLHTAAMHGHLEAVKVLLKRCQYEP 198
+L C K S TPLH AA + +LE + LL+ +
Sbjct: 647 AALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQH-GADV 705
Query: 199 DYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFL 258
+ +D G+ L +A GH+DVA LL+ ++ AC++A D LH AA G+ + L
Sbjct: 706 NAQDKGGLIPLHNAASYGHVDVAALLI-KYNACVNATDKWAFTPLHEAAQKGRTQLCALL 764
Query: 259 VS 260
++
Sbjct: 765 LA 766
Score = 72.0 bits (175), Expect = 6e-13
Identities = 64/250 (25%), Positives = 107/250 (42%), Gaps = 30/250 (12%)
Query: 38 DTLLHCAARHGH--RDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
+T LHCAA + R + L G +I +++ PLH A+ H D V ++ A
Sbjct: 365 ETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEA 424
Query: 96 AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHI------------ 143
V+ L T L A +L + L+ +G +P + + G+ + +
Sbjct: 425 KVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEG 484
Query: 144 --------------ASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKV 189
A++ GD ++ L TV + + TPLH AA + + V+
Sbjct: 485 ISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEY 544
Query: 190 LLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVT 249
LL+ + +D G+ L +A GH +VA LL+ +HGA ++ D LH AA
Sbjct: 545 LLQH-GADVHAKDKGGLVPLHNACSYGHYEVAELLV-KHGAVVNVADLWKFTPLHEAAAK 602
Query: 250 GQDEAIRFLV 259
G+ E + L+
Sbjct: 603 GKYEICKLLL 612
Score = 69.3 bits (168), Expect = 4e-12
Identities = 66/245 (26%), Positives = 112/245 (45%), Gaps = 26/245 (10%)
Query: 39 TLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVD 98
T LH AA + ++ L + G D+ A ++ PLH A S GH + L+ GA V+
Sbjct: 213 TPLHLAAGYNRVKIVQLLLQH-GADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVN 271
Query: 99 CLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHI--------------- 143
+ +TPL A ++ + V L+ +GA+P L N ++ +
Sbjct: 272 AMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFK 331
Query: 144 ------ASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKV--LLKRCQ 195
A+RE D ++ L++ +K + T LH AA + + ++ LL R
Sbjct: 332 GHSLLQAAREADVTRIKKHLSLEMVNFK-HPQTHETALHCAAASPYPKRKQICELLLRKG 390
Query: 196 YEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAI 255
+ + +T L A + H DV +++ +H A ++A D+LG +LHRAA G +
Sbjct: 391 ANINEKTKEFLTPLHVASEKAHNDVVEVVV-KHEAKVNALDNLGQTSLHRAAYCGHLQTC 449
Query: 256 RFLVS 260
R L+S
Sbjct: 450 RLLLS 454
Score = 62.8 bits (151), Expect = 4e-10
Identities = 38/109 (34%), Positives = 56/109 (51%), Gaps = 1/109 (0%)
Query: 39 TLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVD 98
T LH AA + + +V YL + G D+ A ++ PLH AAS GH D L+ A V+
Sbjct: 681 TPLHLAAGYNNLEVAEYLLQH-GADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVN 739
Query: 99 CLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASRE 147
K +TPL A + + L+ HGA+P LKN++G + S +
Sbjct: 740 ATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSAD 788
Score = 44.7 bits (104), Expect = 1e-04
Identities = 62/252 (24%), Positives = 102/252 (40%), Gaps = 31/252 (12%)
Query: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
GD L AA+ G + L+ ++ T + PLH AA + + YLL GA
Sbjct: 645 GDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGAD 704
Query: 97 VDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYL 156
V+ K PL A + ++ V L+++ A +K + H A+++G + L
Sbjct: 705 VNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALL 764
Query: 157 LTVCPGAWKT-ESKIRRTPLHTAAMHGHLEAVKVLLKRCQ--------YEPDYRDNC--- 204
L GA T +++ +TPL + + V LL Y+P +
Sbjct: 765 L--AHGADPTLKNQEGQTPLDLVS----ADDVSALLTAAMPPSALPSCYKPQVLNGVRSP 818
Query: 205 GVTALMDAIQCG-----------HIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDE 253
G TA DA+ G +D E + +S+ + GA +L + V G D
Sbjct: 819 GATA--DALSSGPSSPSSLSAASSLDNLSGSFSELSSVVSSSGTEGASSLEKKEVPGVDF 876
Query: 254 AIRFLVSELGVD 265
+I V LG++
Sbjct: 877 SITQFVRNLGLE 888
>gi|10863929 ribonuclease L [Homo sapiens]
Length = 741
Score = 93.2 bits (230), Expect = 3e-19
Identities = 69/199 (34%), Positives = 108/199 (54%), Gaps = 16/199 (8%)
Query: 85 DCVRYLLGRGAAVDCLKK-ADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHI 143
D V+ LL GA V+ ++ WTPL A +++ L+ HGA+P+L+ K+G F +
Sbjct: 39 DLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFIL 98
Query: 144 ASREGDPLILQYLLTVCPGAWKTESKIRR-TPLHTAAMHGHLEAVKVLLKR--------- 193
A+ G +L+ L+ GA E T AA++G ++A+K L KR
Sbjct: 99 AAIAGSVKLLKLFLS--KGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRK 156
Query: 194 CQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQD- 252
+ + + G TALMDA + GH++V ++LLDE GA ++A D++G AL A ++ D
Sbjct: 157 TKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDS 216
Query: 253 --EAIRFLVSELGVDVDVR 269
EAI L+ + G DV+VR
Sbjct: 217 DVEAITHLLLDHGADVNVR 235
Score = 45.1 bits (105), Expect = 8e-05
Identities = 32/93 (34%), Positives = 46/93 (49%), Gaps = 4/93 (4%)
Query: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPL-HEAASMGHRDC---VRYLLG 92
G T L AA GH +VL L + G D+ A + + L H S D LL
Sbjct: 168 GATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLD 227
Query: 93 RGAAVDCLKKADWTPLMMACTRKNLGVIQELVE 125
GA V+ + TPL++A +K+LG++Q L+E
Sbjct: 228 HGADVNVRGERGKTPLILAVEKKHLGLVQRLLE 260
Score = 38.5 bits (88), Expect = 0.007
Identities = 45/162 (27%), Positives = 75/162 (46%), Gaps = 14/162 (8%)
Query: 77 EAASMGHRDCVRYLLGRGAAVDC----------LKKADWTPLMMACTRKNLGVIQELV-E 125
EAA G +++L RGA V+ L+K T LM A + ++ V++ L+ E
Sbjct: 131 EAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDE 190
Query: 126 HGANPLLKNKDGWNSFH---IASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHG 182
GA+ + G N+ ++S + D + +LL + +TPL A
Sbjct: 191 MGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKK 250
Query: 183 HLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLL 224
HL V+ LL++ E + D+ G TAL+ A++ +A LL
Sbjct: 251 HLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELL 292
Score = 31.6 bits (70), Expect = 0.91
Identities = 27/96 (28%), Positives = 41/96 (42%), Gaps = 7/96 (7%)
Query: 34 GPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGR 93
G G T L A H ++ L E ++I T+ D K L A + + L R
Sbjct: 236 GERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKR 295
Query: 94 GAAVDCLKKADWTPLMMACTRK-NLGVIQELVEHGA 128
GA+ DC L+M R + +++ L+ HGA
Sbjct: 296 GASTDC------GDLVMTARRNYDHSLVKVLLSHGA 325
>gi|30348954 mindbomb homolog 1 [Homo sapiens]
Length = 1006
Score = 92.0 bits (227), Expect = 6e-19
Identities = 65/212 (30%), Positives = 103/212 (48%), Gaps = 4/212 (1%)
Query: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
GD +H AA G + + D+ A N+ + PLH A + GH V+ LL G
Sbjct: 497 GDRAVHHAA-FGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCH 555
Query: 97 VDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYL 156
TPL A ++K ++ L+E GA+ + N +G+N+ H A+ G+P ++ L
Sbjct: 556 PSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVL 615
Query: 157 LTVCPGAWKTESK--IRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQ 214
L+ P W + K T LH AA++ H+E ++L+ + D ++ TAL A++
Sbjct: 616 LSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVE 675
Query: 215 CGHIDVARLLLDEHGACLSAEDSLGAQALHRA 246
H + RLL+ GA L +D G LH A
Sbjct: 676 RQHTQIVRLLV-RAGAKLDIQDKDGDTPLHEA 706
Score = 42.4 bits (98), Expect = 5e-04
Identities = 27/87 (31%), Positives = 39/87 (44%)
Query: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
G T LH AA + H +V L +++ N + + LH A H VR L+ GA
Sbjct: 632 GYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAK 691
Query: 97 VDCLKKADWTPLMMACTRKNLGVIQEL 123
+D K TPL A L +++L
Sbjct: 692 LDIQDKDGDTPLHEALRHHTLSQLRQL 718
>gi|24308163 fem-1 homolog a [Homo sapiens]
Length = 669
Score = 91.3 bits (225), Expect = 1e-18
Identities = 78/231 (33%), Positives = 114/231 (49%), Gaps = 22/231 (9%)
Query: 9 RLCRLVQEGRLRALKEELQ---AAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIE 65
+L + + GR R +EL A GG P L AAR+GH DV+ YL + G +E
Sbjct: 17 QLLQKLLSGRSREELDELTGEVAGGGTP-------LLIAARYGHLDVVEYLVDRCGASVE 69
Query: 66 ATNRDY--------KRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNL 117
A + PL A++ GH D VR LL RGA+V+ + + TPL AC +L
Sbjct: 70 AGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHL 129
Query: 118 GVIQELV-EHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLH 176
V++ LV EH A+ + N+ G I+ +G I +YLL + +K T LH
Sbjct: 130 EVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAK-GNTALH 188
Query: 177 TAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDE 227
A G LE +++LL C+ + RD G+T L+ A GH ++ L+ E
Sbjct: 189 DCAESGSLEILQLLL-GCKARME-RDGYGMTPLLAASVTGHTNIVEYLIQE 237
Score = 52.8 bits (125), Expect = 4e-07
Identities = 54/185 (29%), Positives = 81/185 (43%), Gaps = 23/185 (12%)
Query: 108 LMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTE 167
L+ +R+ L + V G PLL IA+R G +++YL+ C + +
Sbjct: 22 LLSGRSREELDELTGEVAGGGTPLL----------IAARYGHLDVVEYLVDRCGASVEAG 71
Query: 168 SKIR--------RTPLHTAAMHGHLEAVKVLLKR-CQYEPDYRDNCGVTALMDAIQCGHI 218
+ PL A+ GHL+ V+ LL+R R N T L A GH+
Sbjct: 72 GSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNS--TPLRAACFDGHL 129
Query: 219 DVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTAL 278
+V R L+ EH A L + G L + G E R+L+ E G V+ R+ + TAL
Sbjct: 130 EVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLL-EQGAQVNRRSAKGN-TAL 187
Query: 279 HYAAK 283
H A+
Sbjct: 188 HDCAE 192
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 90.5 bits (223), Expect = 2e-18
Identities = 89/314 (28%), Positives = 122/314 (38%), Gaps = 69/314 (21%)
Query: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
G T LH AA +GH +++ L A G +I A ++ +R LH AA MGH D V L+ GA
Sbjct: 115 GRTALHHAALNGHVEMVNLLL-AKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAE 173
Query: 97 VDCLKKADWTPLMMACTR---------KNLG------------------------VIQEL 123
V C K +TPL A + NLG V+ EL
Sbjct: 174 VTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNEL 233
Query: 124 VEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGH 183
+++GAN N +G+ H A+ + LL +SK ++PLH A+HG
Sbjct: 234 IDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGR 293
Query: 184 LEAVKVLLKR------------------CQYEPDYRDNCGVTALMDAIQCG--------- 216
+ L++ +Y + N T+ D +CG
Sbjct: 294 FTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHL 353
Query: 217 -----HIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRAT 271
H D R LL G + D G LH AA G E I+ L S G D +
Sbjct: 354 AALNAHSDCCRKLLSS-GFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSS-GADFH-KKD 410
Query: 272 STHLTALHYAAKPC 285
T LHYAA C
Sbjct: 411 KCGRTPLHYAAANC 424
Score = 88.6 bits (218), Expect = 6e-18
Identities = 79/248 (31%), Positives = 114/248 (45%), Gaps = 9/248 (3%)
Query: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRD-CVRYLLGRGA 95
G+T LH A +G V+ L + +G ++ N + PLH AA+ H C+ L+ GA
Sbjct: 214 GNTALHIACYNGQDAVVNELID-YGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGA 272
Query: 96 AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQY 155
V+ K +PL M Q L+++G +KDG H+A+R G L++
Sbjct: 273 DVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINT 332
Query: 156 LLTVCPGAWKTESKIRRT-PLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQ 214
L T GA + I PLH AA++ H + + LL +E D D G T L A
Sbjct: 333 LRT--SGADTAKCGIHSMFPLHLAALNAHSDCCRKLLS-SGFEIDTPDKFGRTCLHAAAA 389
Query: 215 CGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTH 274
G+++ + LL GA +D G LH AA I LV+ G +V+
Sbjct: 390 GGNVECIK-LLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVT-TGANVN-ETDDWG 446
Query: 275 LTALHYAA 282
TALHYAA
Sbjct: 447 RTALHYAA 454
Score = 87.4 bits (215), Expect = 1e-17
Identities = 65/219 (29%), Positives = 108/219 (49%), Gaps = 5/219 (2%)
Query: 63 DIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQE 122
D+ + + + PLH AA +G + + L+ GA V+ TPL A ++ +Q
Sbjct: 8 DVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQV 67
Query: 123 LVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHG 182
L++H A+ ++K+ H+A+ + ++ + + RT LH AA++G
Sbjct: 68 LIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSV-NVSDRGGRTALHHAALNG 126
Query: 183 HLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQA 242
H+E V +LL + + D AL A GH+DV LL++ HGA ++ +D G
Sbjct: 127 HVEMVNLLLAKGANINAF-DKKDRRALHWAAYMGHLDVVALLIN-HGAEVTCKDKKGYTP 184
Query: 243 LHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYA 281
LH AA GQ ++ L++ LGV++D TALH A
Sbjct: 185 LHAAASNGQINVVKHLLN-LGVEID-EINVYGNTALHIA 221
Score = 86.7 bits (213), Expect = 2e-17
Identities = 72/250 (28%), Positives = 110/250 (44%), Gaps = 41/250 (16%)
Query: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDY-KRPLHEAASMGHRDCVRYLLGRGA 95
G +H AA +GHR L L E E ++ K PLH AA GH + LL
Sbjct: 507 GYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLV 566
Query: 96 AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQY 155
+D + T L +A + + ++ L+ GA+ +K
Sbjct: 567 DLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVK---------------------- 604
Query: 156 LLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEP--DYRDNCGVTALMDAI 213
++ +RTPLH + ++GH +++LL+ D +D G T LM A+
Sbjct: 605 -----------DNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAV 653
Query: 214 QCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRA-TS 272
GHID LLL++ A + D LG ALHR +TG +E ++ L+ + +V + S
Sbjct: 654 AYGHIDAVSLLLEKE-ANVDTVDILGCTALHRGIMTGHEECVQMLLEQ---EVSILCKDS 709
Query: 273 THLTALHYAA 282
T LHYAA
Sbjct: 710 RGRTPLHYAA 719
Score = 83.2 bits (204), Expect = 3e-16
Identities = 75/259 (28%), Positives = 123/259 (47%), Gaps = 37/259 (14%)
Query: 33 PGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLG 92
P G T LH AA G+ + + L + G D ++ + PLH AA+ H C+ L+
Sbjct: 376 PDKFGRTCLHAAAAGGNVECIKLLQSS-GADFHKKDKCGRTPLHYAAANCHFHCIETLVT 434
Query: 93 RGAAVDCLKKADW--TPLMMACT------RKNLG----------------------VIQE 122
GA V+ + DW T L A + LG ++
Sbjct: 435 TGANVN--ETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEF 492
Query: 123 LVEHGANPLLKNKDGWNSFHIASREGDPLILQYLL-TVCPGAWKTESKIRRTPLHTAAMH 181
L+++ ANP +++K+G+NS H A+ G L+ LL G +++S ++PLH AA +
Sbjct: 493 LLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYN 552
Query: 182 GHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQ 241
GH +A++VLL+ + D RD G TAL A GH + L++ GA + +D++ +
Sbjct: 553 GHHQALEVLLQSL-VDLDIRDEKGRTALDLAAFKGHTECVEALINP-GASIFVKDNVTKR 610
Query: 242 A-LHRAAVTGQDEAIRFLV 259
LH + + G +R L+
Sbjct: 611 TPLHASVINGHTLCLRLLL 629
Score = 77.4 bits (189), Expect = 1e-14
Identities = 73/256 (28%), Positives = 110/256 (42%), Gaps = 23/256 (8%)
Query: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
G T L A +GH D ++ L E +++ + LH GH +CV+ LL + +
Sbjct: 645 GQTPLMLAVAYGHIDAVSLLLEKEA-NVDTVDILGCTALHRGIMTGHEECVQMLLEQEVS 703
Query: 97 VDCLKKADWTPLMMACTRKNLGVIQELVEHGANP---LLKNKDGWNSFHIASREGDPLIL 153
+ C TPL A R + + EL++ + K+ G+ H A G+ +
Sbjct: 704 ILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCI 763
Query: 154 QYLLTVCPGAWKTESKIRR-------TPLHTAAMHGHLEAVKVLLKRCQYE-PDYRDNCG 205
+ LL E K R TPLH A ++ H +LL RD+ G
Sbjct: 764 EVLL---------EQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKG 814
Query: 206 VTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVD 265
T L A H++ +LLL H A ++A D+ G AL AA GQ A+ LV+ D
Sbjct: 815 RTPLRAAAFADHVECLQLLL-RHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQAD 873
Query: 266 VDVRATSTHLTALHYA 281
+ V+ + T LH A
Sbjct: 874 LTVKDKDLN-TPLHLA 888
Score = 74.3 bits (181), Expect = 1e-13
Identities = 69/244 (28%), Positives = 113/244 (46%), Gaps = 6/244 (2%)
Query: 39 TLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVD 98
T LH AA G +++ L + G + A + + PLH A + + V+ L+ A V+
Sbjct: 18 TPLHVAAFLGDAEIIELLILS-GARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVN 76
Query: 99 CLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLT 158
K TPL +A K + + ++ ++ + ++ G + H A+ G ++ LL
Sbjct: 77 ARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLA 136
Query: 159 VCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHI 218
+ K RR LH AA GHL+ V +L+ E +D G T L A G I
Sbjct: 137 KGANINAFDKKDRRA-LHWAAYMGHLDVVALLINH-GAEVTCKDKKGYTPLHAAASNGQI 194
Query: 219 DVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTAL 278
+V + LL+ G + + G ALH A GQD + L+ + G +V+ + + T L
Sbjct: 195 NVVKHLLN-LGVEIDEINVYGNTALHIACYNGQDAVVNELI-DYGANVN-QPNNNGFTPL 251
Query: 279 HYAA 282
H+AA
Sbjct: 252 HFAA 255
Score = 73.2 bits (178), Expect = 3e-13
Identities = 85/296 (28%), Positives = 117/296 (39%), Gaps = 34/296 (11%)
Query: 17 GRLRALKEELQAAG--GCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRP 74
GR + +Q G C G+T LH AAR+GH ++L G D P
Sbjct: 292 GRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGH-ELLINTLRTSGADTAKCGIHSMFP 350
Query: 75 LHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKN 134
LH AA H DC R LL G +D K T L A N+ I+ L GA+ K+
Sbjct: 351 LHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKD 410
Query: 135 KDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAA-------------MH 181
K G H A+ ++ L+T +T+ RT LH AA H
Sbjct: 411 KCGRTPLHYAAANCHFHCIETLVTTGANVNETDD-WGRTALHYAAASDMDRNKTILGNAH 469
Query: 182 GHLEAVK--------------VLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDE 227
+ E ++ L + P RD G ++ A GH LLL+
Sbjct: 470 DNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLER 529
Query: 228 HGACLSAEDSLGAQA-LHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAA 282
+ DS ++ LH AA G +A+ L+ L VD+D+R TAL AA
Sbjct: 530 TNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSL-VDLDIRDEKGR-TALDLAA 583
Score = 71.2 bits (173), Expect = 1e-12
Identities = 63/221 (28%), Positives = 98/221 (44%), Gaps = 6/221 (2%)
Query: 64 IEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQEL 123
+ ++R + LH AA GH + V LL +GA ++ K D L A +L V+ L
Sbjct: 108 VNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALL 167
Query: 124 VEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKI-RRTPLHTAAMHG 182
+ HGA K+K G+ H A+ G ++++LL + G E + T LH A +G
Sbjct: 168 INHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNL--GVEIDEINVYGNTALHIACYNG 225
Query: 183 HLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQA 242
V L+ + +N G T L A H + LL +GA ++ + G
Sbjct: 226 QDAVVNELID-YGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSP 284
Query: 243 LHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAK 283
LH AV G+ + L+ G ++D T LH AA+
Sbjct: 285 LHMTAVHGRFTRSQTLIQN-GGEIDC-VDKDGNTPLHVAAR 323
Score = 48.1 bits (113), Expect = 9e-06
Identities = 43/163 (26%), Positives = 64/163 (39%), Gaps = 4/163 (2%)
Query: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGR--G 94
G T LH A +G+ + + L E N PLH A H +C LLG
Sbjct: 747 GYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPF--TPLHCAIINDHGNCASLLLGAIDS 804
Query: 95 AAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQ 154
+ V C TPL A ++ +Q L+ H A + G + +A+ G +
Sbjct: 805 SIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVD 864
Query: 155 YLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYE 197
L+ + K TPLH A GH + ++L + Q E
Sbjct: 865 ILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDE 907
Score = 36.6 bits (83), Expect = 0.028
Identities = 18/58 (31%), Positives = 27/58 (46%)
Query: 36 AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGR 93
+G T L AA +G + L + D+ ++D PLH A S GH C +L +
Sbjct: 846 SGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDK 903
>gi|18079216 CASK interacting protein 1 [Homo sapiens]
Length = 1431
Score = 89.7 bits (221), Expect = 3e-18
Identities = 79/293 (26%), Positives = 138/293 (47%), Gaps = 19/293 (6%)
Query: 5 GDPRRLCRLVQEGRLRALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDI 64
G +RL + + G+ + L + P G + LH AA +G+ ++++ L EA +
Sbjct: 17 GTAQRLLQRPRPGKAKLLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAA-V 75
Query: 65 EATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELV 124
+ + RPLH AA G ++ ++ +L G+AV+ PL +A + V + L+
Sbjct: 76 DIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLL 135
Query: 125 EHGANPLLKNKDGWNSFHIASREGDPLILQYLLT--VC-----PGAWKTESKIRRTPLHT 177
+H +NP + + G +A G ++Q LL+ +C P +PLH
Sbjct: 136 QHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHL 195
Query: 178 AAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDS 237
AA +GH++ +++LL + + + + G TAL +A CG +V RLLLD G ++
Sbjct: 196 AAKNGHIDIIRLLL-QAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDS-GINAHVRNT 252
Query: 238 LGAQAL---HRAAVTGQDEAIRFLVSELGVDVDVRATSTH-----LTALHYAA 282
AL H+ + I+ L+ E + VRAT + LT+L+ A
Sbjct: 253 YSQTALDIVHQFTTSQASREIKQLLREASAALQVRATKDYCNNYDLTSLNVKA 305
>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
Length = 399
Score = 85.5 bits (210), Expect = 5e-17
Identities = 84/252 (33%), Positives = 110/252 (43%), Gaps = 17/252 (6%)
Query: 36 AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
AG T LH A GH ++ L + G + A +R + LHEAA GH LL RGA
Sbjct: 73 AGRTPLHLAVLRGHAPLVRLLLQR-GAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGA 131
Query: 96 AVDCLKKADWTPLMMACTRKNLGVIQELVEH-GANPLLKNKD---GWNSFHIASREGDPL 151
+ TPL A + + L+E G P + GW + H A+ G
Sbjct: 132 SAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLA 191
Query: 152 ILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMD 211
+L+ L G L AA G A++ LL R D RD G TAL
Sbjct: 192 VLELLAAGGAGL--------DGALLVAAAAGRGAALRFLLARGA-RVDARDGAGATALGL 242
Query: 212 AIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRAT 271
A G +LL HGA D G ALHRAA G A++ LV++ G +VD R T
Sbjct: 243 AAALGRSQDIEVLLG-HGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQ-GAEVDARDT 300
Query: 272 STHLTALHYAAK 283
LT LH+A++
Sbjct: 301 -LGLTPLHHASR 311
Score = 76.3 bits (186), Expect = 3e-14
Identities = 79/243 (32%), Positives = 105/243 (43%), Gaps = 54/243 (22%)
Query: 26 LQAAGGCPGPA--------GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHE 77
L+A G PGPA G T H AA G VL LA A G ++ L
Sbjct: 160 LEAPG--PGPAAAEAEDARGWTAAHWAAAGGRLAVLELLA-AGGAGLDGA-------LLV 209
Query: 78 AASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDG 137
AA+ G +R+LL RGA VD A T L +A I+ L+ HGA+P ++++ G
Sbjct: 210 AAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHG 269
Query: 138 WNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYE 197
R+ LH AA GHL AV++L+ + E
Sbjct: 270 ----------------------------------RSALHRAAARGHLLAVQLLVTQGA-E 294
Query: 198 PDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRF 257
D RD G+T L A + GH++VA LLD GA + A L LH AA G +
Sbjct: 295 VDARDTLGLTPLHHASREGHVEVAGCLLD-RGAQVDATGWLRKTPLHLAAERGHGPTVGL 353
Query: 258 LVS 260
L+S
Sbjct: 354 LLS 356
Score = 60.1 bits (144), Expect = 2e-09
Identities = 64/182 (35%), Positives = 81/182 (44%), Gaps = 17/182 (9%)
Query: 17 GRLRALKEELQAAGGCPGPAG-DTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPL 75
GRL L EL AAGG AG D L AA G L +L A G ++A + L
Sbjct: 188 GRLAVL--ELLAAGG----AGLDGALLVAAAAGRGAALRFLL-ARGARVDARDGAGATAL 240
Query: 76 HEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNK 135
AA++G + LLG GA + + L A R +L +Q LV GA ++
Sbjct: 241 GLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDT 300
Query: 136 DGWNSFHIASREGDPLILQYLLT----VCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLL 191
G H ASREG + LL V W +R+TPLH AA GH V +LL
Sbjct: 301 LGLTPLHHASREGHVEVAGCLLDRGAQVDATGW-----LRKTPLHLAAERGHGPTVGLLL 355
Query: 192 KR 193
R
Sbjct: 356 SR 357
Score = 58.9 bits (141), Expect = 5e-09
Identities = 50/160 (31%), Positives = 71/160 (44%), Gaps = 7/160 (4%)
Query: 105 WTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGD-PLILQYLLTVCPGA 163
W L+ A R G++ +L+ GA+ ++ G H+A G PL+ L P
Sbjct: 42 WGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVG 101
Query: 164 WKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARL 223
+ RT LH AA HGH ++LL+R R G+T L A GH +A
Sbjct: 102 --AVDRAGRTALHEAAWHGHSRVAELLLQR-GASAAARSGTGLTPLHWAAALGHTLLAAR 158
Query: 224 LLDEHG---ACLSAEDSLGAQALHRAAVTGQDEAIRFLVS 260
LL+ G A AED+ G A H AA G+ + L +
Sbjct: 159 LLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAA 198
Score = 49.3 bits (116), Expect = 4e-06
Identities = 38/115 (33%), Positives = 53/115 (46%), Gaps = 4/115 (3%)
Query: 24 EELQAAGGCPGPA---GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAAS 80
E L G PG G + LH AA GH + L G +++A + PLH A+
Sbjct: 253 EVLLGHGADPGIRDRHGRSALHRAAARGHL-LAVQLLVTQGAEVDARDTLGLTPLHHASR 311
Query: 81 MGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNK 135
GH + LL RGA VD TPL +A R + + L+ GA+P L+ +
Sbjct: 312 EGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQ 366
>gi|17864094 feminization 1 homolog a [Homo sapiens]
Length = 617
Score = 85.5 bits (210), Expect = 5e-17
Identities = 71/216 (32%), Positives = 104/216 (48%), Gaps = 15/216 (6%)
Query: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDIE---ATNRDYKR-----PLHEAASMGHRDCVR 88
G T L AAR+GH D++ +L E IE + N D + PL A++ GH V+
Sbjct: 41 GATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQ 100
Query: 89 YLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREG 148
LL GA+V+ + TPL AC +L +++ LVEH A+ + N+ G I+ +G
Sbjct: 101 SLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKG 160
Query: 149 DPLILQYLLTVCPGAWKTESKIR-RTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVT 207
I QYLL GA ++ T LH A G L+ +K+LL C +D G+T
Sbjct: 161 HKEIAQYLLE--KGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKME--KDGYGMT 216
Query: 208 ALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQAL 243
L+ A GH ++ L H A S + + A L
Sbjct: 217 PLLSASVTGHTNIVDFL--THHAQTSKTERINALEL 250
Score = 29.3 bits (64), Expect = 4.5
Identities = 18/47 (38%), Positives = 22/47 (46%), Gaps = 1/47 (2%)
Query: 52 VLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVD 98
V A L E G D+ + D PLH AA H D + L+ GA D
Sbjct: 510 VTAILIEC-GADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFD 555
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 84.0 bits (206), Expect = 2e-16
Identities = 77/285 (27%), Positives = 129/285 (45%), Gaps = 39/285 (13%)
Query: 12 RLVQEGRLRAL-----KEELQAAG---GCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMD 63
+L+ G+L ++ E + +AG P G T LH AA G+ + L L + G D
Sbjct: 390 KLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSS-GAD 448
Query: 64 IEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAV-----------------DCLKKADW- 105
+ ++ + PLH AA+ G C L+ GA V D ++A+
Sbjct: 449 LRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPH 508
Query: 106 ----------TPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQY 155
PL + ++ ++ L+++GA+P L+++ G+ + H A+ G+ L+
Sbjct: 509 TPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLEL 568
Query: 156 LLTVCPGAWK-TESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQ 214
LL + + ES I +PLH AA +GH EA+K L + D RD+ G TAL A +
Sbjct: 569 LLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETL-VNLDVRDHKGRTALFLATE 627
Query: 215 CGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLV 259
G + +L + L E LH AA +G +++ L+
Sbjct: 628 RGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLI 672
Score = 79.0 bits (193), Expect = 5e-15
Identities = 63/205 (30%), Positives = 97/205 (47%), Gaps = 9/205 (4%)
Query: 61 GMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWT----PLMMACTRKN 116
G D +R +H AA+ G+R + LL + +CL+ + T PL +A +
Sbjct: 540 GADPSLRDRQGYTAVHYAAAYGNRQNLELLLEM--SFNCLEDVESTIPVSPLHLAAYNGH 597
Query: 117 LGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLH 176
++ L E N +++ G + +A+ G ++ L A E K + TPLH
Sbjct: 598 CEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLH 657
Query: 177 TAAMHGHLEAVKVLLKRCQYE--PDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSA 234
AA GH +++ +L+ + D D G T LM AI GH+D LLL E G+ A
Sbjct: 658 AAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLL-EKGSTADA 716
Query: 235 EDSLGAQALHRAAVTGQDEAIRFLV 259
D G ALHR AVTG ++ + L+
Sbjct: 717 ADLRGRTALHRGAVTGCEDCLAALL 741
Score = 77.4 bits (189), Expect = 1e-14
Identities = 80/270 (29%), Positives = 112/270 (41%), Gaps = 27/270 (10%)
Query: 33 PGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAA-SMGHRDCVRYLL 91
P G+T LH A G V L A G ++ N PLH AA S C+ L+
Sbjct: 235 PNAFGNTALHIACYLGQDAVAIELVNA-GANVNQPNDKGFTPLHVAAVSTNGALCLELLV 293
Query: 92 GRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPL 151
GA V+ K +PL MA Q L+++G+ +K G H+A+R G L
Sbjct: 294 NNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHEL 353
Query: 152 ILQYLLTVCPGAWKTESKIR-RTPLHTAAMHGHLEAVKVLLKRCQ--------------- 195
++ L+T GA I PLH A + G + + LL Q
Sbjct: 354 LISTLMT--NGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLS 411
Query: 196 --YEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDE 253
++ + DN G T L A G+++ LLL GA L D G LH AA G +
Sbjct: 412 AGFDINTPDNLGRTCLHAAASGGNVECLNLLLSS-GADLRRRDKFGRTPLHYAAANGSYQ 470
Query: 254 -AIRFLVSELGVDVDVRATSTHLTALHYAA 282
A+ + + GV+ A + LHYAA
Sbjct: 471 CAVTLVTAGAGVN---EADCKGCSPLHYAA 497
Score = 73.9 bits (180), Expect = 2e-13
Identities = 87/287 (30%), Positives = 119/287 (41%), Gaps = 27/287 (9%)
Query: 17 GRLRALKEELQAAG---GCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKR 73
G L LK L A G GC G LLH AA G +V+ YL G +I+ N
Sbjct: 184 GHLEVLKL-LVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLR-MGAEIDEPNAFGNT 241
Query: 74 PLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQE-LVEHGANPLL 132
LH A +G L+ GA V+ +TPL +A N + E LV +GA+
Sbjct: 242 ALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNY 301
Query: 133 KNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLK 192
++K+G + H+A+ G +L K TPLH AA +GH + L+
Sbjct: 302 QSKEGKSPLHMAAIHG-RFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMT 360
Query: 193 RCQYEPDYRDNCGVTALMDAIQCGHIDVARLLL-------------DEH----GACLSAE 235
+ R + L A+ G D R LL +EH G ++
Sbjct: 361 N-GADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTP 419
Query: 236 DSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAA 282
D+LG LH AA G E + L+S G D+ R T LHYAA
Sbjct: 420 DNLGRTCLHAAASGGNVECLNLLLSS-GADLR-RRDKFGRTPLHYAA 464
Score = 73.6 bits (179), Expect = 2e-13
Identities = 64/219 (29%), Positives = 103/219 (47%), Gaps = 5/219 (2%)
Query: 63 DIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQE 122
+I +++ + PLH AA +G ++ LL GA V+ TPL A +N V+
Sbjct: 33 NINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGL 92
Query: 123 LVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHG 182
L+ H A+ ++K H+A+ + L + + + R+ LH A G
Sbjct: 93 LLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLL-SSLNVADRSGRSALHHAVHSG 151
Query: 183 HLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQA 242
HLE V +LL + + D L A GH++V +LL+ GA L +D G
Sbjct: 152 HLETVNLLLNK-GASLNVCDKKERQPLHWAAFLGHLEVLKLLV-ARGADLGCKDRKGYGL 209
Query: 243 LHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYA 281
LH AA +GQ E +++L+ +G ++D + TALH A
Sbjct: 210 LHTAAASGQIEVVKYLL-RMGAEID-EPNAFGNTALHIA 246
Score = 73.2 bits (178), Expect = 3e-13
Identities = 72/244 (29%), Positives = 109/244 (44%), Gaps = 6/244 (2%)
Query: 39 TLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVD 98
T LH AA G +L L + G ++ A + + PLH AA+ + + LL A V+
Sbjct: 43 TPLHAAAYVGDVPILQLLLMS-GANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVN 101
Query: 99 CLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLT 158
K TPL +A + + L ++ + ++ G ++ H A G + LL
Sbjct: 102 ARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLN 161
Query: 159 VCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHI 218
+ K R PLH AA GHLE +K+L+ R + +D G L A G I
Sbjct: 162 K-GASLNVCDKKERQPLHWAAFLGHLEVLKLLVAR-GADLGCKDRKGYGLLHTAAASGQI 219
Query: 219 DVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTAL 278
+V + LL GA + ++ G ALH A GQD A+ + G +V+ + T L
Sbjct: 220 EVVKYLL-RMGAEIDEPNAFGNTALHIACYLGQD-AVAIELVNAGANVN-QPNDKGFTPL 276
Query: 279 HYAA 282
H AA
Sbjct: 277 HVAA 280
Score = 70.1 bits (170), Expect = 2e-12
Identities = 70/246 (28%), Positives = 111/246 (45%), Gaps = 7/246 (2%)
Query: 39 TLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVD 98
T LH AA + LA + +R + LH A GH + V LL +GA+++
Sbjct: 109 TPLHVAAANRATKCAEALAPLLS-SLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLN 167
Query: 99 CLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLT 158
K + PL A +L V++ LV GA+ K++ G+ H A+ G +++YLL
Sbjct: 168 VCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLR 227
Query: 159 VCPGAWKTE-SKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGH 217
+ GA E + T LH A G +AV + L + ++ G T L A +
Sbjct: 228 M--GAEIDEPNAFGNTALHIACYLGQ-DAVAIELVNAGANVNQPNDKGFTPLHVAAVSTN 284
Query: 218 IDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTA 277
+ LL +GA ++ + G LH AA+ G+ + L+ G ++D A T
Sbjct: 285 GALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQN-GSEIDC-ADKFGNTP 342
Query: 278 LHYAAK 283
LH AA+
Sbjct: 343 LHVAAR 348
Score = 69.3 bits (168), Expect = 4e-12
Identities = 76/281 (27%), Positives = 113/281 (40%), Gaps = 40/281 (14%)
Query: 39 TLLHCAARHGHRDVLAYLAEAWGM-DIEATNRDY-KRPLHEAASMGHRDCVRYLLGRGAA 96
T LH AA GH D L L ++ DI Y + PL A GH DCV LL +G+
Sbjct: 654 TPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGST 713
Query: 97 VDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYL 156
D T L + L++H A L ++ G H+AS G +L+ L
Sbjct: 714 ADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTL 773
Query: 157 LTVCPGAWKTESKI---RRTPLHTAAMHGHLEAVKVLLKRCQYE---------------- 197
L ++ + +P+H A+ GH + +++LL+ +
Sbjct: 774 LQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVIN 833
Query: 198 -----------------PDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGA 240
+ RD G T L A ++ R+LL +H A ++A D G
Sbjct: 834 NQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLL-QHQAEVNATDHTGR 892
Query: 241 QALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYA 281
AL AA GQ A+ FL+ D+ V + + TALH A
Sbjct: 893 TALMTAAENGQTAAVEFLLYRGKADLTVLDENKN-TALHLA 932
Score = 66.2 bits (160), Expect = 3e-11
Identities = 76/285 (26%), Positives = 115/285 (40%), Gaps = 40/285 (14%)
Query: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
G T L A +GH D + L E G +A + + LH A G DC+ LL A
Sbjct: 688 GQTPLMLAIMNGHVDCVHLLLEK-GSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAF 746
Query: 97 VDCLKKADWTPLMMACTRKNLGVIQELVEHG--ANPLLKNKD--GWNSFHIASREGDPLI 152
V C TP+ +A + V++ L++ +PL D G++ H AS G
Sbjct: 747 VLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDC 806
Query: 153 LQYLLTVCPGAW---------------------------------KTESKIRRTPLHTAA 179
L+ LL P ++ + RTPLH AA
Sbjct: 807 LELLLEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAA 866
Query: 180 MHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLG 239
++ +++LL+ Q E + D+ G TALM A + G LL A L+ D
Sbjct: 867 FADNVSGLRMLLQH-QAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENK 925
Query: 240 AQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHL-TALHYAAK 283
ALH A G ++ +++E + AT++ L LH AA+
Sbjct: 926 NTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAAR 970
Score = 61.2 bits (147), Expect = 1e-09
Identities = 74/283 (26%), Positives = 104/283 (36%), Gaps = 47/283 (16%)
Query: 32 CPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLL 91
C G+T LH AAR+GH +++ L G D PLH A G DC R LL
Sbjct: 334 CADKFGNTPLHVAARYGHELLISTLMTN-GADTARRGIHDMFPLHLAVLFGFSDCCRKLL 392
Query: 92 GRGAAVDCLKKAD------------------WTPLMMACTRKNLGVIQELVEHGANPLLK 133
G + T L A + N+ + L+ GA+ +
Sbjct: 393 SSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRR 452
Query: 134 NKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESK-------------IRRTPLHTAAM 180
+K G H A+ G L+T G + + K RR HT +
Sbjct: 453 DKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSS 512
Query: 181 HGHLEAVKVLLKRCQY-------------EPDYRDNCGVTALMDAIQCGHIDVARLLLDE 227
H E + R + +P RD G TA+ A G+ LLL+
Sbjct: 513 HDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEM 572
Query: 228 HGACLS-AEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVR 269
CL E ++ LH AA G EA++ L L V++DVR
Sbjct: 573 SFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETL-VNLDVR 614
Score = 60.8 bits (146), Expect = 1e-09
Identities = 56/193 (29%), Positives = 88/193 (45%), Gaps = 4/193 (2%)
Query: 74 PLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLK 133
PL +A + VR LL + ++ L + TPL A ++ ++Q L+ GAN K
Sbjct: 11 PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
Query: 134 NKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKR 193
+ H A+ + +L LL K+ +TPLH AA + + + L
Sbjct: 71 DTLWLTPLHRAAASRNEKVLGLLLAHSADV-NARDKLWQTPLHVAAANRATKCAEALAPL 129
Query: 194 CQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDE 253
+ D G +AL A+ GH++ LLL++ GA L+ D Q LH AA G E
Sbjct: 130 LS-SLNVADRSGRSALHHAVHSGHLETVNLLLNK-GASLNVCDKKERQPLHWAAFLGHLE 187
Query: 254 AIRFLVSELGVDV 266
++ LV+ G D+
Sbjct: 188 VLKLLVAR-GADL 199
Score = 42.4 bits (98), Expect = 5e-04
Identities = 30/114 (26%), Positives = 45/114 (39%), Gaps = 3/114 (2%)
Query: 27 QAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDC 86
QA G T L AA +G + +L D+ + + LH A S GH C
Sbjct: 881 QAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKC 940
Query: 87 VRYLLGRG---AAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDG 137
+L ++ A PL +A V+Q L+ HGA L +++G
Sbjct: 941 ALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEG 994
Score = 40.4 bits (93), Expect = 0.002
Identities = 29/82 (35%), Positives = 38/82 (46%), Gaps = 2/82 (2%)
Query: 38 DTLLHCAARHGHRD-VLAYLAEAWGMD-IEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
+T LH A GH L LAE + I ATN + PLH AA G V+ LL GA
Sbjct: 926 NTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGA 985
Query: 96 AVDCLKKADWTPLMMACTRKNL 117
V + + TP + K++
Sbjct: 986 TVLAVDEEGHTPALACAPNKDV 1007
>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
sapiens]
Length = 522
Score = 83.6 bits (205), Expect = 2e-16
Identities = 63/218 (28%), Positives = 104/218 (47%), Gaps = 9/218 (4%)
Query: 12 RLVQEGRLRALKEELQAAGGCP----GPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEAT 67
R + G+L AL + GC G+T LH AA GH VL L + G+D+E
Sbjct: 165 RAAEHGQLDAL--DFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDI-GLDLEEQ 221
Query: 68 NRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHG 127
N + LH AA H DCV+ LL G+ V+ L + + + L A + V + L+ G
Sbjct: 222 NAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAG 281
Query: 128 ANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAV 187
+ + G + H+A R P +++ L+ +++ ++TPLH AA H +
Sbjct: 282 GCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNR-QQTPLHLAAEHAWQDIA 340
Query: 188 KVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLL 225
+LL + + RD G TAL A++ H+ + +++
Sbjct: 341 DMLL-IAGVDLNLRDKQGKTALAVAVRSNHVSLVDMII 377
Score = 81.3 bits (199), Expect = 1e-15
Identities = 80/256 (31%), Positives = 123/256 (48%), Gaps = 22/256 (8%)
Query: 41 LHCAARHGHRDVLAYLAEAWGMDIEATNRDY--KRPLHEAASMGHRDCVRYLLGRGAAVD 98
LH AAR + + + E G + R++ + LH AA GH VR LL AAVD
Sbjct: 19 LHEAARQNN---VGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVD 75
Query: 99 ------CLKKA----DWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREG 148
L +A L+++ +L ++Q LV GA ++KDG H A+++G
Sbjct: 76 EEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKG 135
Query: 149 DPLILQYLLTVCPG-AWKTESKIRRTPLHTAAMHGHLEAVKVLL-KRCQYEPDYRDNCGV 206
+L +++ A K+ RT H AA HG L+A+ L+ C + + +D G
Sbjct: 136 HVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDH--NVKDKEGN 193
Query: 207 TALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDV 266
TAL A GH+ V + L+D G L +++ G ALH AA + ++ L+ G V
Sbjct: 194 TALHLAAGRGHMAVLQRLVD-IGLDLEEQNAEGLTALHSAAGGSHPDCVQLLL-RAGSTV 251
Query: 267 DVRATSTHLTALHYAA 282
+ T +L+ LHYAA
Sbjct: 252 NA-LTQKNLSCLHYAA 266
Score = 76.3 bits (186), Expect = 3e-14
Identities = 74/246 (30%), Positives = 117/246 (47%), Gaps = 19/246 (7%)
Query: 32 CPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDY-----KRPLHEAASMGHRDC 86
C G TLLHCAA+ GH VLA++ E D+E D+ + H AA G D
Sbjct: 119 CESKDGLTLLHCAAQKGHVPVLAFIME----DLEDVALDHVDKLGRTAFHRAAEHGQLDA 174
Query: 87 VRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASR 146
+ +L+G G + K T L +A R ++ V+Q LV+ G + +N +G + H A+
Sbjct: 175 LDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAG 234
Query: 147 EGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKR--CQYEPDYRDNC 204
P +Q LL K + LH AA+ G + +VL+ C D++
Sbjct: 235 GSHPDCVQLLLRAGSTVNALTQK-NLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQ--- 290
Query: 205 GVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAV-TGQDEAIRFLVSELG 263
G + L A++ + RLL++ + ++A D+ LH AA QD A L++ G
Sbjct: 291 GASPLHLAVRHNFPALVRLLINS-DSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIA--G 347
Query: 264 VDVDVR 269
VD+++R
Sbjct: 348 VDLNLR 353
>gi|155969701 espin-like [Homo sapiens]
Length = 1005
Score = 80.9 bits (198), Expect = 1e-15
Identities = 71/242 (29%), Positives = 113/242 (46%), Gaps = 4/242 (1%)
Query: 44 AARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKA 103
AA+ G L L EA + T+ +H A GH DCV++L+ R +
Sbjct: 9 AAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRAH 68
Query: 104 DW-TPLMMACTRKNLGVIQELVEHGANPLL-KNKDGWNSFHIASREGDPLILQYLLTVCP 161
+ TP A +L + LV G L ++ G + H+A+R G P+++++LL
Sbjct: 69 NGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEGH 128
Query: 162 GAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVA 221
A E++ PLH AA+ G L +K+L + R G + L A Q GH+ +A
Sbjct: 129 SA-TLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLA 187
Query: 222 RLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYA 281
+ L+ + GA + G ALH AA G + +LV+ + + R + TALH+A
Sbjct: 188 QFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTAR-DNEGATALHFA 246
Query: 282 AK 283
A+
Sbjct: 247 AR 248
Score = 79.3 bits (194), Expect = 4e-15
Identities = 79/283 (27%), Positives = 116/283 (40%), Gaps = 7/283 (2%)
Query: 19 LRALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEA 78
++ L + Q G G T H AA G L +L G ++ + PLH A
Sbjct: 52 VKFLVQRAQLPGNQRAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLA 111
Query: 79 ASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVE-HGANPLLKNKDG 137
A GH V +LL G + + PL A +L ++ L HG++ + + G
Sbjct: 112 ARFGHPVLVEWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSG 171
Query: 138 WNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYE 197
+ ++A +EG + Q+L+ C + + LH AA GH V L+
Sbjct: 172 ASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIG 231
Query: 198 PDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRF 257
RDN G TAL A + GH + LL L DS G LH AA GQ E +
Sbjct: 232 LTARDNEGATALHFAARGGHTPILDRLLLMGTPIL--RDSWGGTPLHDAAENGQMECCQT 289
Query: 258 LVSELGVDVDVRATSTHLT---ALHYAAKPCIWPVQVSTWPVP 297
LVS VD +R + A ++ + C ++ PVP
Sbjct: 290 LVSH-HVDPSLRDEDGYTAADLAEYHGHRDCAQYLREVAQPVP 331
Score = 76.3 bits (186), Expect = 3e-14
Identities = 66/250 (26%), Positives = 109/250 (43%), Gaps = 10/250 (4%)
Query: 2 AQPGDPRRLCRLVQEGRLRALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAWG 61
A+ GD L RL++ G L G G L+H A R GH D + +L +
Sbjct: 10 AKDGDVATLERLLEAGAL---------GPGITDALGAGLVHHATRAGHLDCVKFLVQRAQ 60
Query: 62 MDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA-VDCLKKADWTPLMMACTRKNLGVI 120
+ + P H+AA+ G + +L+ G + + +PL +A + ++
Sbjct: 61 LPGNQRAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLV 120
Query: 121 QELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAM 180
+ L+ G + L+ ++G H A+ GD L+ L + ++ +PL+ A
Sbjct: 121 EWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQ 180
Query: 181 HGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGA 240
GHL + L+K C + R G++AL A GH + L+ L+A D+ GA
Sbjct: 181 EGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGA 240
Query: 241 QALHRAAVTG 250
ALH AA G
Sbjct: 241 TALHFAARGG 250
Score = 50.4 bits (119), Expect = 2e-06
Identities = 35/119 (29%), Positives = 54/119 (45%)
Query: 143 IASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRD 202
+A+++GD L+ LL + +H A GHL+ VK L++R Q + R
Sbjct: 8 VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRA 67
Query: 203 NCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSE 261
+ G T DA G + L+ E G L +D+ G LH AA G + +L+ E
Sbjct: 68 HNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHE 126
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.136 0.436
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,795,036
Number of Sequences: 37866
Number of extensions: 559759
Number of successful extensions: 5010
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 297
Number of HSP's successfully gapped in prelim test: 46
Number of HSP's that attempted gapping in prelim test: 1288
Number of HSP's gapped (non-prelim): 1476
length of query: 304
length of database: 18,247,518
effective HSP length: 102
effective length of query: 202
effective length of database: 14,385,186
effective search space: 2905807572
effective search space used: 2905807572
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.