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Search of human proteins with 134244585
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|134244585 putative neuronal cell adhesion molecule [Homo
sapiens]
(814 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|134244585 putative neuronal cell adhesion molecule [Homo sapi... 1640 0.0
gi|239747467 PREDICTED: similar to hCG1996527 [Homo sapiens] 525 e-149
gi|239741341 PREDICTED: similar to hCG1996527 [Homo sapiens] 525 e-149
gi|169162264 PREDICTED: similar to hCG1996527 [Homo sapiens] 522 e-148
gi|83281200 protogenin [Homo sapiens] 478 e-134
gi|19882241 immunoglobulin superfamily, DCC subclass, member 4 [... 397 e-110
gi|110431348 deleted in colorectal carcinoma [Homo sapiens] 256 8e-68
gi|157311649 neogenin homolog 1 [Homo sapiens] 241 3e-63
gi|15147240 brother of CDO [Homo sapiens] 178 2e-44
gi|75709184 contactin 3 [Homo sapiens] 177 3e-44
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 172 1e-42
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 172 1e-42
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 172 1e-42
gi|19743806 roundabout 1 isoform b [Homo sapiens] 168 2e-41
gi|4506569 roundabout 1 isoform a [Homo sapiens] 168 2e-41
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 167 4e-41
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 167 4e-41
gi|7657361 contactin 6 [Homo sapiens] 164 4e-40
gi|224994173 roundabout 1 isoform d [Homo sapiens] 163 7e-40
gi|224994171 roundabout 1 isoform c [Homo sapiens] 163 7e-40
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 163 7e-40
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ... 163 7e-40
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ... 162 1e-39
gi|222352127 sidekick 2 [Homo sapiens] 161 2e-39
gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo... 161 3e-39
gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo ... 161 3e-39
gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo s... 161 3e-39
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ... 159 1e-38
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ... 159 1e-38
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 158 2e-38
>gi|134244585 putative neuronal cell adhesion molecule [Homo
sapiens]
Length = 814
Score = 1640 bits (4247), Expect = 0.0
Identities = 814/814 (100%), Positives = 814/814 (100%)
Query: 1 MAVQRAASPRRPPAPLWPRLLLPLLLLLLPAPSEGLGHSAELAFAVEPSDDVAVPGQPIV 60
MAVQRAASPRRPPAPLWPRLLLPLLLLLLPAPSEGLGHSAELAFAVEPSDDVAVPGQPIV
Sbjct: 1 MAVQRAASPRRPPAPLWPRLLLPLLLLLLPAPSEGLGHSAELAFAVEPSDDVAVPGQPIV 60
Query: 61 LDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRLEPGGSPSDEGDYECVAQ 120
LDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRLEPGGSPSDEGDYECVAQ
Sbjct: 61 LDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRLEPGGSPSDEGDYECVAQ 120
Query: 121 NRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGLPKPLITWEKNRVPID 180
NRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGLPKPLITWEKNRVPID
Sbjct: 121 NRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGLPKPLITWEKNRVPID 180
Query: 181 TDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLTVSGSGSGAYKEPAI 240
TDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLTVSGSGSGAYKEPAI
Sbjct: 181 TDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLTVSGSGSGAYKEPAI 240
Query: 241 LVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEGIQVLGTGNLIISDVTVQ 300
LVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEGIQVLGTGNLIISDVTVQ
Sbjct: 241 LVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEGIQVLGTGNLIISDVTVQ 300
Query: 301 HSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPH 360
HSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPH
Sbjct: 301 HSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPH 360
Query: 361 VTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTVLWA 420
VTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTVLWA
Sbjct: 361 VTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTVLWA 420
Query: 421 EGLPGPPRNVRAVSVSSTEVRVSWSEPLANTKEIIGYVLHIRKAADPPELEYQEAVSKST 480
EGLPGPPRNVRAVSVSSTEVRVSWSEPLANTKEIIGYVLHIRKAADPPELEYQEAVSKST
Sbjct: 421 EGLPGPPRNVRAVSVSSTEVRVSWSEPLANTKEIIGYVLHIRKAADPPELEYQEAVSKST 480
Query: 481 FQHLVSDLEPSTAYSFYIKAYTPRGASSASVPTLASTLGEAPAPPPLSVRVLGSSSLQLL 540
FQHLVSDLEPSTAYSFYIKAYTPRGASSASVPTLASTLGEAPAPPPLSVRVLGSSSLQLL
Sbjct: 481 FQHLVSDLEPSTAYSFYIKAYTPRGASSASVPTLASTLGEAPAPPPLSVRVLGSSSLQLL 540
Query: 541 WEPWPRLAQHEGGFKLFYRPASKTSFTGPILLPGTVSSYNLSQLDPTAVYEVKLLAYNQH 600
WEPWPRLAQHEGGFKLFYRPASKTSFTGPILLPGTVSSYNLSQLDPTAVYEVKLLAYNQH
Sbjct: 541 WEPWPRLAQHEGGFKLFYRPASKTSFTGPILLPGTVSSYNLSQLDPTAVYEVKLLAYNQH 600
Query: 601 GDGNATVRFVSLRGASERTALSPPCDCRKEEAANQTSTTGIVIGIHIGVTCIIFCVLFLL 660
GDGNATVRFVSLRGASERTALSPPCDCRKEEAANQTSTTGIVIGIHIGVTCIIFCVLFLL
Sbjct: 601 GDGNATVRFVSLRGASERTALSPPCDCRKEEAANQTSTTGIVIGIHIGVTCIIFCVLFLL 660
Query: 661 FGQRGRVLLCKDVENQLSPPQGPRSQRDPGILALNGARRGQRGQLGRDEKRVDMKELEQL 720
FGQRGRVLLCKDVENQLSPPQGPRSQRDPGILALNGARRGQRGQLGRDEKRVDMKELEQL
Sbjct: 661 FGQRGRVLLCKDVENQLSPPQGPRSQRDPGILALNGARRGQRGQLGRDEKRVDMKELEQL 720
Query: 721 FPPASAAGQPDPRPTQDPAAPAPCEETQLSVLPLQGCGLMEGKTTEAKTTEATAPCAGLA 780
FPPASAAGQPDPRPTQDPAAPAPCEETQLSVLPLQGCGLMEGKTTEAKTTEATAPCAGLA
Sbjct: 721 FPPASAAGQPDPRPTQDPAAPAPCEETQLSVLPLQGCGLMEGKTTEAKTTEATAPCAGLA 780
Query: 781 AAPPPPDGGPGLLSEGQASRPAAARVTQPAHSEQ 814
AAPPPPDGGPGLLSEGQASRPAAARVTQPAHSEQ
Sbjct: 781 AAPPPPDGGPGLLSEGQASRPAAARVTQPAHSEQ 814
>gi|239747467 PREDICTED: similar to hCG1996527 [Homo sapiens]
Length = 654
Score = 525 bits (1353), Expect = e-149
Identities = 313/698 (44%), Positives = 409/698 (58%), Gaps = 107/698 (15%)
Query: 26 LLLLPAPSEGLGHSAELAFAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPES 85
LLLL P G +ELAF E D VAV P+VL C+VEG PPV I+W+++ + L
Sbjct: 3 LLLLLLPGWGCAAGSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANE 62
Query: 86 THSTLLANGSLMIRHFRLEPG--GSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHV 143
+ TL+ +GSL H P PS +Y CVAQNR+G +VSR+AR+Q A++S FH
Sbjct: 63 SGVTLMPDGSL---HLAALPSRRSLPSRAHEYHCVAQNRYGRLVSRRARVQLASLSRFHQ 119
Query: 144 HPQATVGEEGGVARFQCQIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAED 203
HP++ E GGVA FQC I G+P+P I+WE N ++T N R TLLP G+L IT + D
Sbjct: 120 HPESIEVERGGVACFQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTD 179
Query: 204 GGIFHCVASNIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATG 263
G + CVA N+AS R S A+LT+S +EP IL GP+NLTLTVHQTAVLEC+AT
Sbjct: 180 MGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATS 239
Query: 264 NPRPIVSWSRLDGRPIGVEGIQV---LGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTA 320
+P P+VSWSRLDGR IGVEGIQV L TGNL+ISDV+VQHSGVYVCAANRPGT VRRTA
Sbjct: 240 HPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTA 299
Query: 321 QGRLVVQ--------------------------------------APA---------EFV 333
QG L+VQ AP+ EFV
Sbjct: 300 QGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFV 359
Query: 334 QHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPE 393
Q PQS+S+P G++A+FTC AQG P + WLKNG+VL PG ++RL +NNSTL ++G+ E
Sbjct: 360 QWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVE 419
Query: 394 DEAIYQCVAENSAGSSQASARLTVLWAEGLPGPPRNVRAVSVSSTEVRVSWSEPLANTKE 453
DEAIYQCVAENS GS+QASARL V P P S+ V + P ++++
Sbjct: 420 DEAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGPACHGSLYFCHSSVLGATP-PSSRD 478
Query: 454 IIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKAYTPRGASSASVPT 513
IIGYVLH+R +P E QEA+SK T +H+ S+LEP+TAY+ +++AY+ GAS S P
Sbjct: 479 IIGYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQDSAPI 538
Query: 514 LASTLGEAPAPPPLSVRVLGSSSLQLLWEPWPRLAQHEGGFKLFYRPASKTSFTGPILLP 573
AST+G LG +L L P+ L
Sbjct: 539 FASTMGSN----------LG-EALNL-----------------------------PVPLK 558
Query: 574 GTVSSYNLSQLDPTAVYEVKLLAYNQHGDGNATVRFVSLR-------GASERTALSPPCD 626
+S +L+ +P A+Y++KL A+N +GDGN++ R VSLR + T C
Sbjct: 559 ACLSQCDLAP-EPAALYDIKLQAFNGNGDGNSSARCVSLRDVPLATPDGTVSTESKTGCS 617
Query: 627 CRKEEAANQTSTTGIVIGIHIGVTCIIFCVLFLLFGQR 664
C + E+ + G+V+GIH+G+ +I C+L L G R
Sbjct: 618 CSQGES---SPLPGVVVGIHVGLAALIICLLCLFLGWR 652
>gi|239741341 PREDICTED: similar to hCG1996527 [Homo sapiens]
Length = 654
Score = 525 bits (1353), Expect = e-149
Identities = 313/698 (44%), Positives = 409/698 (58%), Gaps = 107/698 (15%)
Query: 26 LLLLPAPSEGLGHSAELAFAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPES 85
LLLL P G +ELAF E D VAV P+VL C+VEG PPV I+W+++ + L
Sbjct: 3 LLLLLLPGWGCAAGSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANE 62
Query: 86 THSTLLANGSLMIRHFRLEPG--GSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHV 143
+ TL+ +GSL H P PS +Y CVAQNR+G +VSR+AR+Q A++S FH
Sbjct: 63 SGVTLMPDGSL---HLAALPSRRSLPSRAHEYHCVAQNRYGRLVSRQARVQLASLSRFHQ 119
Query: 144 HPQATVGEEGGVARFQCQIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAED 203
HP++ E GGVARFQC I G+P+P I+WE N ++T N R TLLP G+L IT + D
Sbjct: 120 HPESIEVERGGVARFQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTD 179
Query: 204 GGIFHCVASNIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATG 263
G + CVA N+AS R S A+LT+S +EP IL GP+NLTLTVHQTAVLEC+AT
Sbjct: 180 MGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATS 239
Query: 264 NPRPIVSWSRLDGRPIGVEGIQV---LGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTA 320
+P P+VSWSRLDGR IGVEGIQV L TGNL+ISDV+VQHSGVYVCAANRPGT VRRTA
Sbjct: 240 HPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTA 299
Query: 321 QGRLVVQ--------------------------------------APA---------EFV 333
QG L+VQ AP+ EFV
Sbjct: 300 QGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFV 359
Query: 334 QHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPE 393
Q PQS+S+P G++A+FTC AQG P + WLKNG+VL PG ++RL +NNSTL ++G+ E
Sbjct: 360 QWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVE 419
Query: 394 DEAIYQCVAENSAGSSQASARLTVLWAEGLPGPPRNVRAVSVSSTEVRVSWSEPLANTKE 453
DEAIYQCVAENS GS+QASARL V P P S+ V + P ++++
Sbjct: 420 DEAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGPACHGSLYFCHSSVLGATP-PSSRD 478
Query: 454 IIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKAYTPRGASSASVPT 513
IIGYVLH+R +P E QEA+SK T +H+ S+LEP+TAY+ +++AY+ GAS S P
Sbjct: 479 IIGYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQDSAPI 538
Query: 514 LASTLGEAPAPPPLSVRVLGSSSLQLLWEPWPRLAQHEGGFKLFYRPASKTSFTGPILLP 573
AST+G LG +L L P+ L
Sbjct: 539 FASTMGSN----------LG-EALNL-----------------------------PVPLK 558
Query: 574 GTVSSYNLSQLDPTAVYEVKLLAYNQHGDGNATVRFVSL-------RGASERTALSPPCD 626
+S +L+ +P A+Y++KL A+N +GDGN++ R VSL + T C
Sbjct: 559 ACLSQCDLAP-EPAALYDIKLQAFNGNGDGNSSARCVSLCDVPLATPDGTVSTESKTGCS 617
Query: 627 CRKEEAANQTSTTGIVIGIHIGVTCIIFCVLFLLFGQR 664
C + E+ + G+V+GIH+G+ +I C+L L G R
Sbjct: 618 CSQGES---SPLPGVVVGIHVGLAALIICLLCLFLGWR 652
>gi|169162264 PREDICTED: similar to hCG1996527 [Homo sapiens]
Length = 654
Score = 522 bits (1345), Expect = e-148
Identities = 312/698 (44%), Positives = 408/698 (58%), Gaps = 107/698 (15%)
Query: 26 LLLLPAPSEGLGHSAELAFAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPES 85
LLLL P G +ELAF E D VAV P+VL C+VEG PPV I+W+++ + L
Sbjct: 3 LLLLLLPGWGCAAGSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANE 62
Query: 86 THSTLLANGSLMIRHFRLEPG--GSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHV 143
+ TL+ +GSL H P PS +Y CVAQNR+G +VSR+AR+Q A++S FH
Sbjct: 63 SGVTLMPDGSL---HLAALPSRRSLPSRAHEYHCVAQNRYGRLVSRQARVQLASLSRFHQ 119
Query: 144 HPQATVGEEGGVARFQCQIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAED 203
HP++ E GGVA FQC I G+P+P I+WE N ++T N R TLLP G+L IT + D
Sbjct: 120 HPESIEVERGGVACFQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTD 179
Query: 204 GGIFHCVASNIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATG 263
G + CVA N+AS R S A+LT+S +EP IL GP+NLTLTVHQTAVLEC+AT
Sbjct: 180 MGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATS 239
Query: 264 NPRPIVSWSRLDGRPIGVEGIQV---LGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTA 320
+P P+VSWSRLDGR IGVEGIQV L TGNL+ISDV+VQHSGVYVCAANRPGT VRRTA
Sbjct: 240 HPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTA 299
Query: 321 QGRLVVQ--------------------------------------APA---------EFV 333
QG L+VQ AP+ EFV
Sbjct: 300 QGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFV 359
Query: 334 QHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPE 393
Q PQS+S+P G++A+FTC AQG P + WLKNG+VL PG ++RL +NNSTL ++G+ E
Sbjct: 360 QWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVE 419
Query: 394 DEAIYQCVAENSAGSSQASARLTVLWAEGLPGPPRNVRAVSVSSTEVRVSWSEPLANTKE 453
DEAIYQCVAENS GS+QASARL V P P S+ V + P ++++
Sbjct: 420 DEAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGPACHGSLYFCHSSVLGATP-PSSRD 478
Query: 454 IIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKAYTPRGASSASVPT 513
IIGYVLH+R +P E QEA+SK T +H+ S+LEP+TAY+ +++AY+ GAS S P
Sbjct: 479 IIGYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQDSAPI 538
Query: 514 LASTLGEAPAPPPLSVRVLGSSSLQLLWEPWPRLAQHEGGFKLFYRPASKTSFTGPILLP 573
AST+G LG +L L P+ L
Sbjct: 539 FASTMGSN----------LG-EALNL-----------------------------PVPLK 558
Query: 574 GTVSSYNLSQLDPTAVYEVKLLAYNQHGDGNATVRFVSL-------RGASERTALSPPCD 626
+S +L+ +P A+Y++KL A+N +GDGN++ R VSL + T C
Sbjct: 559 ACLSQCDLAP-EPAALYDIKLQAFNGNGDGNSSARCVSLCDVPLATPDGTVSTESKTGCS 617
Query: 627 CRKEEAANQTSTTGIVIGIHIGVTCIIFCVLFLLFGQR 664
C + E+ + G+V+GIH+G+ +I C+L L G R
Sbjct: 618 CSQGES---SPLPGVVVGIHVGLAALIICLLCLFLGWR 652
>gi|83281200 protogenin [Homo sapiens]
Length = 1150
Score = 478 bits (1229), Expect = e-134
Identities = 266/608 (43%), Positives = 366/608 (60%), Gaps = 12/608 (1%)
Query: 7 ASPRRPPAPLWP--RLLLPLLLLLLPAPSEGLGHSAELAFAVEPSDDVAVPGQPIVLDCR 64
A P RP A L P LL LLLLLL +P G+ +EL+F EP D P+VLDC+
Sbjct: 2 APPLRPLARLRPPGMLLRALLLLLLLSPLPGVWCFSELSFVKEPQDVTVTRKDPVVLDCQ 61
Query: 65 VEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFG 124
G P+++TW KNG ++ E+ +L+NGSL I G SDEG Y+C+A N++G
Sbjct: 62 AHGEVPIKVTWLKNGAKMSENKRIEVLSNGSLYISEVEGRRG-EQSDEGFYQCLAMNKYG 120
Query: 125 LVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGLPKPLITWEKNRVPIDTDNE 184
++S+KA + +T+S F V P +T EGGVARF C+I P +ITWE NR + +
Sbjct: 121 AILSQKAHLALSTISAFEVQPISTEVHEGGVARFACKISSHPPAVITWEFNRTTLPMTMD 180
Query: 185 RYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLTV-SGSGSGAYKEPAILVG 243
R T LP GVLQI + D G + C+A+ +A R S A LTV S ++ P I+ G
Sbjct: 181 RITALPTGVLQIYDVSQRDSGNYRCIAATVAHRRKSMEASLTVIPAKESKSFHTPTIIAG 240
Query: 244 PENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEGIQVLGTGNLIISDVTVQHSG 303
P+N+T ++HQT VLEC+ATGNP+PI+SWSRLD + I V +VLG GNL+ISDV +QH+G
Sbjct: 241 PQNITTSLHQTVVLECMATGNPKPIISWSRLDHKSIDVFNTRVLGNGNLMISDVRLQHAG 300
Query: 304 VYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTW 363
VYVC A PGTR A L V AP FV+ P+S++RP TA F CQA+G P P ++W
Sbjct: 301 VYVCRATTPGTRNFTVAMATLTVLAPPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSW 360
Query: 364 LKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAEGL 423
LKNG+ + G R+K NS L I+ I PED+AIYQC+AENS GS + ARLTV+ +E
Sbjct: 361 LKNGRKIHSNG--RIKMYNSKLVINQIIPEDDAIYQCMAENSQGSILSRARLTVVMSEDR 418
Query: 424 PGPPRNVRAVSVSSTEVRVSWSEPLANTKEIIGYVLHIRKAADPPELEYQEAVSKSTFQH 483
P P NV A ++SS+ + ++W PL N+ ++I Y +H KA EYQ + T +
Sbjct: 419 PSAPYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHY 478
Query: 484 LVSDLEPSTAYSFYIKAYTPRGASSASVPTLASTLGEAP-APPPLSVRVLGSSSLQLLWE 542
++ DLEP++ Y+FYI AY P GAS S +TL + P PP +S+ + + + W
Sbjct: 479 IIDDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPEISLTSRSPTDILISWL 538
Query: 543 PWPRLAQHEGGFKLFYRPASKTSFTGPIL---LPGTVSSYNLSQLDPTAVYEVKLLAYNQ 599
P P A++ G + YR + + S I LPGT Y L L P +VY V++ A +
Sbjct: 539 PIP--AKYRRGQVVLYRLSFRLSTENSIQVLELPGTTHEYLLEGLKPDSVYLVRITAATR 596
Query: 600 HGDGNATV 607
G G ++V
Sbjct: 597 VGLGESSV 604
Score = 83.6 bits (205), Expect = 7e-16
Identities = 90/365 (24%), Positives = 150/365 (41%), Gaps = 31/365 (8%)
Query: 374 GHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSS-QASARLTVLWAEGL-------PG 425
G + L + T+SG+ P + + +A N+ QA ++ + P
Sbjct: 664 GPIFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQADQTVSTPGCVSVRDRMVPPPP 723
Query: 426 PPRNVRAVSVSSTEVRVSWSEPLANTKEIIGYVLHIRKAADPPELEYQEAV---SKSTFQ 482
PP ++ A + +S+ + + W P +II Y + +P L+ V S
Sbjct: 724 PPHHLYAKANTSSSIFLHWRRPAFTAAQIINYTIR----CNPVGLQNASLVLYLQTSETH 779
Query: 483 HLVSDLEPSTAYSFYIKAYTPRGASSASVPTLASTLGEAPAPPPLSVRV--LGSSSLQLL 540
LV LEP+T Y F ++ + + +S S STL EAPA PP+ V+V + + +
Sbjct: 780 MLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLPEAPAGPPVGVKVTLIEDDTALVS 839
Query: 541 WEPWPRLAQHEGGFKLFY--RPASKTSFTGPILLPGTVSSYNLSQLDPTAVYEVKLLAYN 598
W+P + + Y R A + G ++ L L VY VK+ A N
Sbjct: 840 WKPPDGPETVVTRYTILYASRKAWIAGEWQVLHREGAITMALLENLVAGNVYIVKISASN 899
Query: 599 QHGDG---NATVRFVSLRGASERTALSPPCDCRKEEA------ANQTSTTGIVIGIHIGV 649
+ G+G N+ V + SE D + +Q S TGI +G+ I +
Sbjct: 900 EVGEGPFSNSVELAVLPKETSESNQRPKRLDSADAKVYSGYYHLDQKSMTGIAVGVGIAL 959
Query: 650 TCIIFCVLFLLFGQRGRVLLCKDVENQLSPPQGPRSQRDPGILALNGARRGQRGQLGRDE 709
TCI+ CVL L++ + R Q Q PR+ + + N + G +G +E
Sbjct: 960 TCILICVLILIYRSKARKSSASKTA-QNGTQQLPRT--SASLASGNEVGKNLEGAVGNEE 1016
Query: 710 KRVDM 714
+ M
Sbjct: 1017 SLMPM 1021
Score = 71.2 bits (173), Expect = 4e-12
Identities = 127/581 (21%), Positives = 214/581 (36%), Gaps = 84/581 (14%)
Query: 57 QPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRLEPGGSPSDEGDYE 116
Q +VL+C G P I+W + + + ++ +L NG+LMI RL+ G Y
Sbjct: 250 QTVVLECMATGNPKPIISWSRLDHKSIDVFNTRVLGNGNLMISDVRLQHAGV------YV 303
Query: 117 CVAQNRFGLVVSRKARIQAATMS-----DFHVHPQATVGEEGGVARFQCQIHGLPKPLIT 171
C A +R + AT++ F P++ G ARF CQ G+P P ++
Sbjct: 304 CRATTPG----TRNFTVAMATLTVLAPPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMS 359
Query: 172 WEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLTVSGSG 231
W KN I ++ K L I + ED I+ C+A N +S ARLTV S
Sbjct: 360 WLKNGRKIHSNGRIKMYNSK--LVINQIIPEDDAIYQCMAENSQGSILSR-ARLTVVMSE 416
Query: 232 ---SGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWS--RLDGRPIGVEGIQV 286
S Y A + + L + N ++++S + + E QV
Sbjct: 417 DRPSAPYNVHAETMSSSAILLAWERPLY-------NSDKVIAYSVHYMKAEGLNNEEYQV 469
Query: 287 L---GTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQ-HPQSISRP 342
+ T + II D+ + + A P + + V Q E V P IS
Sbjct: 470 VIGNDTTHYIIDDLEPASNYTFYIVAYMP---MGASQMSDHVTQNTLEDVPLRPPEISLT 526
Query: 343 AGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTIS-----------GIG 391
+ + P + + GQV+ RL NS + G+
Sbjct: 527 SRSPTDILISWLPIPAKY----RRGQVVLYRLSFRLSTENSIQVLELPGTTHEYLLEGLK 582
Query: 392 PEDEAIYQCVAENSAGSSQASARLTVLWAEGLPGPPRNVRAVS--------VSSTEVRVS 443
P+ + + A G ++S +W +V+A ++ T + V
Sbjct: 583 PDSVYLVRITAATRVGLGESS-----VWTSHRTPKATSVKAPKSPELHLEPLNCTTISVR 637
Query: 444 WSEPLANTKEIIGYVLHIRKAAD----PPELEYQEAVSKSTFQHLVSDLEPSTAYSFYIK 499
W + + +T I GY L+ ++ P L+ ++ + + +S L+P Y +
Sbjct: 638 WQQDVEDTAAIQGYKLYYKEEGQQENGPIFLDTKDLL------YTLSGLDPRRKYHVRLL 691
Query: 500 AYTP-----RGASSASVPTLASTLGEAPAPPP----LSVRVLGSSSLQLLWEPWPRLAQH 550
AY + + S P S PPP L + SSS+ L W A
Sbjct: 692 AYNNIDDGYQADQTVSTPGCVSVRDRMVPPPPPPHHLYAKANTSSSIFLHWRRPAFTAAQ 751
Query: 551 EGGFKLFYRPASKTSFTGPILLPGTVSSYNLSQLDPTAVYE 591
+ + P + + + L + + + L+P YE
Sbjct: 752 IINYTIRCNPVGLQNASLVLYLQTSETHMLVQGLEPNTKYE 792
>gi|19882241 immunoglobulin superfamily, DCC subclass, member 4
[Homo sapiens]
Length = 1250
Score = 397 bits (1021), Expect = e-110
Identities = 244/605 (40%), Positives = 334/605 (55%), Gaps = 24/605 (3%)
Query: 19 RLLLPLLLLLLPAPSEGL---GHSAELAFAVEPSDDVAVPGQPIVLDCRVEGT---PPVR 72
R LL L LL A E L + EL+ V P + P Q VL+C + PP R
Sbjct: 10 RGLLALTFCLLAARGELLLPQETTVELSCGVGPLQVILGPEQAAVLNCSLGAAAAGPPTR 69
Query: 73 ITWRKNGVELPESTHSTLLANGSLMIRHFRLEPGGSPSD--------EGDYECVAQNRFG 124
+TW K+G L E H LL NGSL + L P GS EG+Y C+A G
Sbjct: 70 VTWSKDGDTLLEHDHLHLLPNGSLWLSQ-PLAPNGSDESVPEAVGVIEGNYSCLAHGPLG 128
Query: 125 LVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGLPKPLITWEKNRVPIDTDNE 184
++ S+ A ++ AT++DF +HP++ EE G ARF+C I GLP P+ITWEK++V + +
Sbjct: 129 VLASQTAVVKLATLADFSLHPESQTVEENGTARFECHIEGLPAPIITWEKDQVTLP-EEP 187
Query: 185 RYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLTVSGSGSGAY---KEPAIL 241
R +LP GVLQI ++ D G + CVA+N A S A L+V+ GS A ++ I+
Sbjct: 188 RLIVLPNGVLQILDVQESDAGPYRCVATNSARQHFSQEALLSVAHRGSLASTRGQDVVIV 247
Query: 242 VGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEGIQVLGTGNLIISDVTVQH 301
PEN T+ Q+ V+ECVA+ +P P VSW R DG+PI + I VLG NL+I++ H
Sbjct: 248 AAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGKPISTDVI-VLGRTNLLIANAQPWH 306
Query: 302 SGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHV 361
SGVYVC AN+P TR TA L V A Q P+++SR +TA F C+A GEP P +
Sbjct: 307 SGVYVCRANKPRTRDFATAAAELRVLAAPAITQAPEALSRTRASTARFVCRASGEPRPAL 366
Query: 362 TWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAE 421
WL NG L P G V+++ +L I+ IG +D YQCVAENSAG + A+A L V+ E
Sbjct: 367 RWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSAGMACAAASLAVVVRE 426
Query: 422 GLPGPPRNVRAVSVSSTEVRVSWSEPLANTKEIIGYVLHIRKAADPPELEYQEAVSKSTF 481
GLP P V A +SS+ V V+W P ++++IIG+ LH +KA +EYQ AV+ T
Sbjct: 427 GLPSAPTRVTATPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTT 486
Query: 482 QHLVSDLEPSTAYSFYIKAYTPRGASSASVPTLASTLGEAP-APPPLSVRVLGSSSLQLL 540
+ V DLEP+T Y FY+ AY+ GAS S P L TL + P A P LS+ S +++
Sbjct: 487 ELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQLSLSSPNPSDIRVA 546
Query: 541 WEPWPRLAQHEG--GFKLFYRPASKTSFTGPILLPGTVSSYNLSQLDPTAVYEVKLLAYN 598
W P P + +K+ Y K + G + L+ L P VY V++ A
Sbjct: 547 WLPLPPSLSNGQVVKYKIEY-GLGKEDQIFSTEVRGNETQLMLNSLQPNKVYRVRISAGT 605
Query: 599 QHGDG 603
G G
Sbjct: 606 AAGFG 610
Score = 146 bits (369), Expect = 7e-35
Identities = 156/620 (25%), Positives = 246/620 (39%), Gaps = 90/620 (14%)
Query: 44 FAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRL 103
F++ P +C +EG P ITW K+ V LPE +L NG L I +
Sbjct: 145 FSLHPESQTVEENGTARFECHIEGLPAPIITWEKDQVTLPEEPRLIVLPNGVLQILDVQ- 203
Query: 104 EPGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFH----------VHPQATVGEEG 153
SD G Y CVA N S++A + A P+ T G
Sbjct: 204 -----ESDAGPYRCVATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSG 258
Query: 154 GVARFQCQIHGLPKPLITW-EKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVAS 212
+C P P ++W ++ PI TD +L + L I + G++ C A+
Sbjct: 259 QSVVMECVASADPTPFVSWVRQDGKPISTD---VIVLGRTNLLIANAQPWHSGVYVCRAN 315
Query: 213 NIASIRISHGA-RLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSW 271
+ + A L V + PAI PE L+ T TA C A+G PRP + W
Sbjct: 316 KPRTRDFATAAAELRVLAA-------PAITQAPEALSRTRASTARFVCRASGEPRPALRW 368
Query: 272 SRLDGRPIGVEG-IQVLGTG-NLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQ-- 327
+G P+ G ++V G G +L+I+ + +Q +G Y C A A +VV+
Sbjct: 369 LH-NGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSAGMACAAASLAVVVREG 427
Query: 328 ---APAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVR------- 377
AP P S S A P H + Q++G H +
Sbjct: 428 LPSAPTRVTATPLSSSA--------VLVAWERPEMH-----SEQIIGFSLHYQKARGMDN 474
Query: 378 ------LKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAEGLPGPPRNVR 431
+ N+ + L + + P + + VA + G+S+ S V + +P +
Sbjct: 475 VEYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQLS 534
Query: 432 AVSVSSTEVRVSWSE--PLANTKEIIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLE 489
S + +++RV+W P + +++ Y I + + V + Q +++ L+
Sbjct: 535 LSSPNPSDIRVAWLPLPPSLSNGQVVKY--KIEYGLGKEDQIFSTEVRGNETQLMLNSLQ 592
Query: 490 PSTAYSFYIKAYTPRGASSAS------VPTLASTLGEAPAPPPLSVRVLGSSSLQLLWEP 543
P+ Y I A T G + S P++ + AP L V+ SL + W+P
Sbjct: 593 PNKVYRVRISAGTAAGFGAPSQWMHHRTPSMHNQSHVPFAPAELKVQAK-MESLVVSWQP 651
Query: 544 WPRLAQHEGGFKLFYRPASKTSFT----------------GPILLPGTVSSYNLSQLDPT 587
P Q G +KL++R GP+ L V Y L+QL P
Sbjct: 652 PPHPTQISG-YKLYWREVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPG 710
Query: 588 AVYEVKLLAYNQHGDGNATV 607
+YEVKL+A+N+H DG A V
Sbjct: 711 RLYEVKLVAFNKHEDGYAAV 730
Score = 72.8 bits (177), Expect = 1e-12
Identities = 187/834 (22%), Positives = 289/834 (34%), Gaps = 181/834 (21%)
Query: 63 CRVEGTPPVRITWRKNGVEL-PESTHSTLLANGSLMIRHFRLEPGGSPSDEGDYECVAQN 121
CR G P + W NG L P GSL+I L+ D G Y+CVA+N
Sbjct: 356 CRASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQ------DAGYYQCVAEN 409
Query: 122 RFGLVVSRKARIQAATMSDFHVHPQATVGEEG---GVARFQCQIHGLPKPLITWEKNRVP 178
G+ + AA++ A V EG R L+ WE+ +
Sbjct: 410 SAGMACA------AASL--------AVVVREGLPSAPTRVTATPLSSSAVLVAWERPEMH 455
Query: 179 IDT--------------DNERYTLLPKG---VLQITGLRAEDGGIFHCVASNIASIRISH 221
+ DN Y LQ+ L F+ VA
Sbjct: 456 SEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQVRDLEPNTDYEFYVVA---------- 505
Query: 222 GARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPI-VSWSRL-----D 275
S G+ PA++ +++ Q ++ ++ NP I V+W L +
Sbjct: 506 -----YSQLGASRTSTPALVHTLDDVPSAAPQLSL----SSPNPSDIRVAWLPLPPSLSN 556
Query: 276 GRPIGVEGIQVLGTGNLIISDVTVQHSGVYVCAANRPGT--RVRRTAQGRLVVQAPAEFV 333
G+ + + LG + I S + + + +P RVR +A AP++++
Sbjct: 557 GQVVKYKIEYGLGKEDQIFSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWM 616
Query: 334 QHP----QSISRPAGTTAMFTCQAQGE-------PPPHVTWLK---------------NG 367
H + S A QA+ E PPPH T + NG
Sbjct: 617 HHRTPSMHNQSHVPFAPAELKVQAKMESLVVSWQPPPHPTQISGYKLYWREVGAEEEANG 676
Query: 368 QVLGPG--------GHVRLKNNNSTLTISGIGPEDEAIYQCVAENS---------AGSSQ 410
L G G VRLK ++ + P + VA N G ++
Sbjct: 677 DRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTE 736
Query: 411 ASARLTVLWAEGLPGPPRNVRAVSVSSTEVRVSWSEPLANTKEIIGYVLHIRKAADPPEL 470
+ + G P PP +V A S SST + + W +P T +I+ Y + P L
Sbjct: 737 KAPAPDMPIQRGPPLPPAHVHAESNSSTSIWLRWKKPDFTTVKIVNYTVRF----SPWGL 792
Query: 471 EYQEAVSKSTFQH---LVSDLEPSTAYSFYIKAYTPRGASSASVPTLASTLGEAPAPPPL 527
V+ T L+ L+P T Y F ++++ STL + P+ PP
Sbjct: 793 RNASLVTYYTSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPSTPPS 852
Query: 528 SVRV--LGSSSLQLLWEPWPRLAQHEGGFKLFYRPASKTSFTGP------ILLPGTVSSY 579
+R+ L S+++L W P G + Y ++ T P + G + S
Sbjct: 853 DLRLSPLTPSTVRLHWCP----PTEPNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSA 908
Query: 580 NLSQLDPTAVYEVKLLAYNQHGDGNATVRFVSLRGASERTALSPPCDCRKEEAANQTSTT 639
+ L+ Y K+ A + G G + R + E+ + ++ + S T
Sbjct: 909 EVHGLESDTRYFFKMGARTEVGPGPFS-RLQDVITLQEKLS----------DSLDMHSVT 957
Query: 640 GIVIGIHIGVTCIIFCVLFLLFGQRGRVLLCKDVENQLSPPQGPRSQRDPGILALNGARR 699
GI++G+ +G+ C++ C+ L R L G S PG AL
Sbjct: 958 GIIVGVCLGLLCLLACMCAGLRRSPHRESL-----------PGLSSTATPGNPALY---- 1002
Query: 700 GQRGQLGRDEKRVDMKELEQLFPPASAAGQPDPRPTQDPAAPAPCEETQLSVLPLQGCGL 759
R +LG ELE L P P P +D A V L G G+
Sbjct: 1003 -SRARLGPPSPPA-AHELESLVHPHPQDWSPPPSDVEDRA----------EVHSLMGGGV 1050
Query: 760 MEGKTTEAKTTEATAPC----AGLAAAPPPPDGGPGLLSEGQASRPAAARVTQP 809
EG++ + P AG A P GP RPA R P
Sbjct: 1051 SEGRSHSKRKISWAQPSGLSWAGSWAGCELPQAGP---------RPALTRALLP 1095
>gi|110431348 deleted in colorectal carcinoma [Homo sapiens]
Length = 1447
Score = 256 bits (653), Expect = 8e-68
Identities = 192/589 (32%), Positives = 281/589 (47%), Gaps = 42/589 (7%)
Query: 42 LAFAVEPSDDVAVPGQPIVLDCRVE---GTPPVRITWRKNGVELP--ESTHSTLLANGSL 96
L F EPSD V + G ++LDC E G P ++ W+K+G+ L L+NGSL
Sbjct: 40 LRFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIK--WKKDGIHLALGMDERKQQLSNGSL 97
Query: 97 MIRHFRLEPGGSPSDEGDYECVAQ-NRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGV 155
+I++ P DEG Y+C A G ++SR A++ A F ++ G
Sbjct: 98 LIQNILHSRHHKP-DEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDT 156
Query: 156 ARFQCQIHGLPKPLITWEKNR---VPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVAS 212
+C++ G P P I W+KN+ PI D+ R +LP G LQI+ L+ D GI+ C A
Sbjct: 157 VLLKCEVIGEPMPTIHWQKNQQDLTPIPGDS-RVVVLPSGALQISRLQPGDIGIYRCSAR 215
Query: 213 NIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWS 272
N AS R + A + + S G +++ L P N+ + AVLEC +G P P +W
Sbjct: 216 NPASSRTGNEAEVRIL-SDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWL 274
Query: 273 RLDGRPIGVEGIQV-------LGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLV 325
R G E IQ+ LG NL+IS+VT SG+Y C + +A+ L
Sbjct: 275 R------GEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAE--LT 326
Query: 326 VQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTL 385
V P F+ HP ++ F C G+P P V W+KNG V+ P + ++ S L
Sbjct: 327 VLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIV-GGSNL 385
Query: 386 TISGIGPEDEAIYQCVAENSAGSSQASARL-----TVLWAEGLPGPPRNVRAVSVSSTEV 440
I G+ DE YQCVAEN AG++Q SA+L + + LP PR+V V VSS V
Sbjct: 386 RILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFV 445
Query: 441 RVSWSEPLANTKEIIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKA 500
R+SW P I + + + D E + Q V +L+P Y+F + A
Sbjct: 446 RLSWRPPAEAKGNIQTFTVFFSREGDNRE-RALNTTQPGSLQLTVGNLKPEAMYTFRVVA 504
Query: 501 YTPRGASSASVPTLASTLGEAPAPPPL-SVRVLGSS--SLQLLWEPWPRLAQHEGGFKLF 557
Y G +S P +T E P P+ +++ + +S S+ + WEP G++LF
Sbjct: 505 YNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPAYANGPVQGYRLF 564
Query: 558 YRPASKTSFTGPILLPGTVSSYNLSQLDPTAVYEVKLLAYNQHGDGNAT 606
S T I + G SY L L Y ++ LAYN++G G +T
Sbjct: 565 CTEVS-TGKEQNIEVDGL--SYKLEGLKKFTEYSLRFLAYNRYGPGVST 610
Score = 112 bits (279), Expect = 2e-24
Identities = 147/617 (23%), Positives = 246/617 (39%), Gaps = 64/617 (10%)
Query: 37 GHSAELAFAVEPSDDVAVPGQPIVLDCRVEGTPPVRITW-RKNGVELPESTHSTLLANGS 95
G +L F PS+ VA+ G+ VL+C V G PP TW R V S +LL +
Sbjct: 235 GLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSN 294
Query: 96 LMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGV 155
L+I + + D G Y CV + +S A + F HP E
Sbjct: 295 LLISNV------TDDDSGMYTCVVTYK-NENISASAELTVLVPPWFLNHPSNLYAYESMD 347
Query: 156 ARFQCQIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASN-- 213
F+C + G P P + W KN + ++ + ++ L+I G+ D G + CVA N
Sbjct: 348 IEFECTVSGKPVPTVNWMKNG-DVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEA 406
Query: 214 -----IASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPI 268
A + + A + S S +LV + L+ A A GN +
Sbjct: 407 GNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPA----EAKGNIQTF 462
Query: 269 VSWSRLDGRPIGVEGIQVLGTGNLIISDVTVQHSGVY---VCAANR--PGTR---VRRTA 320
+ +G + G+L ++ ++ +Y V A N PG ++
Sbjct: 463 TVFFSREG-DNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVAT 521
Query: 321 QGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLG--------- 371
Q L V P E +Q A +T+ + EPP + NG V G
Sbjct: 522 QPELQVPGPVENLQ--------AVSTSPTSILITWEPPAYA----NGPVQGYRLFCTEVS 569
Query: 372 PGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAEGLP-GPPRNV 430
G ++ + + + G+ E + +A N G ++ +TV+ +P PP+NV
Sbjct: 570 TGKEQNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNV 629
Query: 431 RAVSVSSTEVRVSWSEPLANTKE--IIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDL 488
V+S ++VSW P + T+ I GY + RK E+ E + + +L + L
Sbjct: 630 SLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEM---ETLEPNNLWYLFTGL 686
Query: 489 EPSTAYSFYIKAYTPRGASSAS----VPTLASTLGEAPAP-PPLSVRVLGSSSLQLL-WE 542
E + YSF + A T G S T + L E+ P P S+ V ++ ++ W
Sbjct: 687 EKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTNCIIMSWT 746
Query: 543 PWPRLAQHEGGFKLFYRPASKTSFTGPILLPGTVSSYNLSQLDPTAVYEVKLLAYNQHGD 602
P G+ + Y S + T + + Y++ +L+ ++ Y + L A+N G+
Sbjct: 747 PPLNPNIVVRGYIIGYGVGSPYAET--VRVDSKQRYYSIERLESSSHYVISLKAFNNAGE 804
Query: 603 GNATVRFVSLRGASERT 619
G + R ++ T
Sbjct: 805 GVPLYESATTRSITDPT 821
Score = 70.9 bits (172), Expect = 5e-12
Identities = 62/215 (28%), Positives = 97/215 (45%), Gaps = 17/215 (7%)
Query: 223 ARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPR-PIVSWSRLDGRPIGV 281
A L V+G A+ L P + +L+C A + P++ W + DG + +
Sbjct: 25 AHLQVTGFQIKAFTALRFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKK-DGIHLAL 83
Query: 282 ---EGIQVLGTGNLIISDVTVQH-----SGVYVCAANR--PGTRVRRTAQGRLVVQAPAE 331
E Q L G+L+I ++ G+Y C A+ G+ + RTA ++ V P
Sbjct: 84 GMDERKQQLSNGSLLIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTA--KVAVAGPLR 141
Query: 332 FVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLG--PGGHVRLKNNNSTLTISG 389
F+ +S++ G T + C+ GEP P + W KN Q L PG + + L IS
Sbjct: 142 FLSQTESVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISR 201
Query: 390 IGPEDEAIYQCVAENSAGSSQAS-ARLTVLWAEGL 423
+ P D IY+C A N A S + A + +L GL
Sbjct: 202 LQPGDIGIYRCSARNPASSRTGNEAEVRILSDPGL 236
Score = 43.1 bits (100), Expect = 0.001
Identities = 42/188 (22%), Positives = 78/188 (41%), Gaps = 12/188 (6%)
Query: 426 PPRNVRAVSVSSTEVRVSWSEPLA----NTKEIIGYVLHIRKAADPPELEYQEAVSKSTF 481
PP V+AV+++ VRVSW++ T E+ Y + R + E ++
Sbjct: 846 PPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSE--DTTSL 903
Query: 482 QHLVSDLEPSTAYSFYIKAYTPRGASSASVPTLASTLGEAPAPPPLSVRVLGSS----SL 537
+ + L+P+T Y F + R +S+ S+ A+T AP P + V+ ++
Sbjct: 904 SYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAV 963
Query: 538 QLLWEPWPRLAQHEGGFKLFYRPASKTSFTGPIL--LPGTVSSYNLSQLDPTAVYEVKLL 595
+ W+P + LFY I+ + G ++ + L+ +Y ++
Sbjct: 964 IVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQ 1023
Query: 596 AYNQHGDG 603
A N G G
Sbjct: 1024 ARNSKGVG 1031
>gi|157311649 neogenin homolog 1 [Homo sapiens]
Length = 1461
Score = 241 bits (614), Expect = 3e-63
Identities = 174/596 (29%), Positives = 275/596 (46%), Gaps = 29/596 (4%)
Query: 44 FAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNG--VELPESTHSTLLANGSLMIRHF 101
F VEP D ++V G ++L+C P +I W+K+G + L LL +GSL I +
Sbjct: 55 FLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNV 114
Query: 102 RLEPGGSPSDEGDYECVAQ-NRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQC 160
P DEG Y+CVA G ++SR A++ A + F P+ + G A C
Sbjct: 115 VHSKHNKP-DEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNC 173
Query: 161 QIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRIS 220
+++ P + WE+NR P+ D +R LP G+L I+ DGG++ CV + + S
Sbjct: 174 EVNADLVPFVRWEQNRQPLLLD-DRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYS 232
Query: 221 HGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSR----LDG 276
L V + L P L + Q VL CVA+G P P + W + LD
Sbjct: 233 DEVELKVLPDPE-VISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDT 291
Query: 277 RPIGVEGIQVLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHP 336
E + +L G+L ISDVT +G Y C A+ + AQ L VQA EF++ P
Sbjct: 292 E--SSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIE--AQAELTVQAQPEFLKQP 347
Query: 337 QSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEA 396
+I +F C+ G+P P V W+KNG ++ P + ++ ++ L + G+ DE
Sbjct: 348 TNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHN-LQVLGLVKSDEG 406
Query: 397 IYQCVAENSAGSSQASARLTVL-----WAEGLPGPPRNVRAVSVSSTEVRVSWSEPLANT 451
YQC+AEN G++QA A+L +L LP PR+V A VS+ ++++W P ++
Sbjct: 407 FYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDP 466
Query: 452 K-EIIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKAYTPRGASSAS 510
+ + Y + K E + Q + +L P+T Y F + A G+ +S
Sbjct: 467 HGDNLTYSVFYTKEGIARE-RVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESS 525
Query: 511 VPTLASTLGEAPAP---PPLSVRVLGSSSLQLLWEPWPRLAQHEGGFKLFYRPASKTSFT 567
P T E P P L +S+ + WE +KL+Y
Sbjct: 526 APLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKGTDKEQ 585
Query: 568 GPILLPGTVSSYNLSQLDPTAVYEVKLLAYNQHGDGNATVRFVSLRGASERTALSP 623
+ + SY ++ L Y +++AYN+HG G +T V++R S+ + +P
Sbjct: 586 D---VDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPD-VAVRTLSDVPSAAP 637
Score = 179 bits (455), Expect = 7e-45
Identities = 161/588 (27%), Positives = 243/588 (41%), Gaps = 45/588 (7%)
Query: 44 FAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRL 103
F +P G +L+C V + W +N L L +G L+I +
Sbjct: 154 FTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISN--- 210
Query: 104 EPGGSPSDEGDYECVAQN----RFGLVVSRKARIQAATMSD--FHVHPQATVGEEGGVAR 157
+ D G Y CV ++ ++ V K +SD F P V G
Sbjct: 211 ---ATEGDGGLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVV 267
Query: 158 FQCQIHGLPKPLITWEKNRVPIDTDN-ERYTLLPKGVLQITGLRAEDGGIFHCVASNIAS 216
C GLP P I W KN +DT++ ER LL G L+I+ + +D G + C+A N +
Sbjct: 268 LPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADN-GN 326
Query: 217 IRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDG 276
I A LTV +P L P N+ V EC TG P P V W +
Sbjct: 327 ETIEAQAELTVQA-------QPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGD 379
Query: 277 RPIGVEGIQVLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHP 336
I + +++ NL + + G Y C A + AQ ++ APA P
Sbjct: 380 MVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLP 439
Query: 337 QS----ISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNST------LT 386
+ ++ T + PH L G R + N++ +T
Sbjct: 440 SAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVT 499
Query: 387 ISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAEG--LPGPPRNVRAVSVSSTEVRVSW 444
I + P I++ +A+N GS ++SA L V LPGP N+RA + S T + V+W
Sbjct: 500 IQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTW 559
Query: 445 SEPLANTKEIIGYVL-HIRKAADPPELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKAYTP 503
P++ EI Y L ++ K D ++ V S+ + ++ L+ T YSF + AY
Sbjct: 560 ETPVSGNGEIQNYKLYYMEKGTDK-----EQDVDVSSHSYTINGLKKYTEYSFRVVAYNK 614
Query: 504 RGASSASVPTLASTLGEAP--APPPLSVRVLGSSSLQLLWEPWPRLAQHEG---GFKLFY 558
G ++ TL + P AP LS+ V S S+ + W+P P A G G+K+ Y
Sbjct: 615 HGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQP-PAPATQNGQITGYKIRY 673
Query: 559 RPASKTSFTGPILLPGTVSSYNLSQLDPTAVYEVKLLAYNQHGDGNAT 606
R AS+ S L+ GT S + LD Y ++ A +G G AT
Sbjct: 674 RKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPAT 721
Score = 115 bits (289), Expect = 1e-25
Identities = 149/598 (24%), Positives = 235/598 (39%), Gaps = 60/598 (10%)
Query: 40 AELAFAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKN--GVELPESTHSTLLANGSLM 97
++L F +PS V V GQ +VL C G P I W KN ++ S LLA GSL
Sbjct: 247 SDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLE 306
Query: 98 IRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVAR 157
I + D G Y C+A N + +A + +F P E
Sbjct: 307 ISDV------TEDDAGTYFCIADNG-NETIEAQAELTVQAQPEFLKQPTNIYAHESMDIV 359
Query: 158 FQCQIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNI--- 214
F+C++ G P P + W KN + ++ + ++ + LQ+ GL D G + C+A N
Sbjct: 360 FECEVTGKPTPTVKWVKNGDMV-IPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGN 418
Query: 215 ----ASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVS 270
A + I A T S A LV + LT A +P
Sbjct: 419 AQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPA-------SDPHGDNL 471
Query: 271 WSRLDGRPIGVEGIQVLGTGNLIISDVTVQH---SGVY---VCAANRPGT-------RVR 317
+ G+ +V T + VT+Q+ + VY V A N+ G+ RV
Sbjct: 472 TYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVE 531
Query: 318 RTAQGRLVVQAP--AEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGH 375
+ +L AP + P SI+ T GE + + G
Sbjct: 532 TQPEVQLPGPAPNLRAYAASPTSIT----VTWETPVSGNGEIQNYKLYYME---KGTDKE 584
Query: 376 VRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAEGLP-GPPRNVRAVS 434
+ ++ + TI+G+ E ++ VA N G ++ + V +P P+N+
Sbjct: 585 QDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEV 644
Query: 435 VSSTEVRVSWSEPLANTK--EIIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPST 492
+S + + W P T+ +I GY + RKA+ ++ + VS + L+ L+ T
Sbjct: 645 RNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVT-ETLVSGTQLSQLIEGLDRGT 703
Query: 493 AYSFYIKAYTPRGASSA----SVPTLASTLGEA---PAPPPLSVRVLGSSSLQLLWEPWP 545
Y+F + A T G A S T S L E P L VR L +S+ + W P
Sbjct: 704 EYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPL-VTSIVVSWTPPE 762
Query: 546 RLAQHEGGFKLFYRPASKTSFTGPILLPGTVSSYNLSQLDPTAVYEVKLLAYNQHGDG 603
G+ + Y S + T I + Y + LDP++ Y + L A+N G+G
Sbjct: 763 NQNIVVRGYAIGYGIGSPHAQT--IKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEG 818
Score = 98.6 bits (244), Expect = 2e-20
Identities = 132/543 (24%), Positives = 208/543 (38%), Gaps = 65/543 (11%)
Query: 131 ARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGLPKPLITWEKNRVPID-TDNERYTLL 189
A I+ T F V P T+ G C + P P I W+K+ ++ ++R LL
Sbjct: 45 ASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLL 104
Query: 190 PKGVLQITGL-----RAEDGGIFHCVAS--NIASIRISHGARLTVSGSGSGAYKEPAILV 242
P G L I+ + D G + CVA+ ++ +I IS A+L V+G P
Sbjct: 105 PDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTI-ISRTAKLIVAGL-------PRFTS 156
Query: 243 GPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEGIQVLGTGNLIISDVTVQHS 302
PE ++ A+L C + P V W + + + + L +G L+IS+ T
Sbjct: 157 QPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDG 216
Query: 303 GVYVCAANRPGTRVRRTAQGRLVVQAP-----AEFVQHPQSISRPAGTTAMFTCQAQGEP 357
G+Y C G V+ P F++ P + R G + C A G P
Sbjct: 217 GLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLP 276
Query: 358 PPHVTWLKNGQVLGPGGHVRL-KNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLT 416
P + W+KN + L RL +L IS + +D Y C+A+N + +A A LT
Sbjct: 277 TPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELT 336
Query: 417 VLWAEGLPGPPRNVRAVS----VSSTEVRVSWSEPLANTKEIIGYVLHIRKAADPPELEY 472
V P N+ A V EV +P K + + I +Y
Sbjct: 337 VQAQPEFLKQPTNIYAHESMDIVFECEVT---GKPTPTVKWVKNGDMVIPS-------DY 386
Query: 473 QEAVSKSTFQHLVSDLEPSTAYSFYIKAYTPRGASSASVPTL-----ASTLGEAP-APPP 526
+ V + Q V L S + A G + A + +T G P AP
Sbjct: 387 FKIVKEHNLQ--VLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRD 444
Query: 527 LSVRVLGSSSLQLLWEPWPRLAQHEGG--FKLFY-------RPASKTSFTGPILLPGTVS 577
+ ++ + ++L W P H + +FY TS G +
Sbjct: 445 VVASLVSTRFIKLTWRT-PASDPHGDNLTYSVFYTKEGIARERVENTSHPGEM------- 496
Query: 578 SYNLSQLDPTAVYEVKLLAYNQHGDGNATVRFVSLRGASE-RTALSPPCDCRKEEAANQT 636
+ L P VY +++A N+HG G ++ LR ++ L P + AA+ T
Sbjct: 497 QVTIQNLMPATVYIFRVMAQNKHGSGESS---APLRVETQPEVQLPGPAPNLRAYAASPT 553
Query: 637 STT 639
S T
Sbjct: 554 SIT 556
Score = 50.1 bits (118), Expect = 8e-06
Identities = 44/187 (23%), Positives = 81/187 (43%), Gaps = 10/187 (5%)
Query: 426 PPRNVRAVSVSSTEVRVSWSE-PLANTKEIIG--YVLHIRKAADPPELEYQEAVSKSTFQ 482
PP V+A +S +R++W++ L ++I Y K P +Y+ A + +T
Sbjct: 856 PPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNA-NATTLS 914
Query: 483 HLVSDLEPSTAYSFYIKAYTPRGASSASVPTLASTLGEAPAPPPLSVRVLGS----SSLQ 538
+LV+ L+P+T Y F + R +S+ S+ +T P PP V V+ ++
Sbjct: 915 YLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTII 974
Query: 539 LLWEPWPRLAQHEGGFKLFYRPASKTSFTGPILLP--GTVSSYNLSQLDPTAVYEVKLLA 596
+ W+P G+ ++Y ++ P G ++ + +L Y K+ A
Sbjct: 975 VNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQA 1034
Query: 597 YNQHGDG 603
N G G
Sbjct: 1035 RNSKGMG 1041
>gi|15147240 brother of CDO [Homo sapiens]
Length = 1114
Score = 178 bits (452), Expect = 2e-44
Identities = 175/613 (28%), Positives = 267/613 (43%), Gaps = 87/613 (14%)
Query: 18 PRLLLPLLLLLLPAPSEGLGHSAELAFAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRK 77
P + L LLL L ++ V+P+ V PG ++L C VE P + +TWR
Sbjct: 14 PEVTLACLLLATAGCFADLNEVPQVT--VQPASTVQKPGGTVILGCVVE-PPRMNVTWRL 70
Query: 78 NGVELPESTHS--TLLANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQA 135
NG EL S + L+ +G+L+I + G Y+CVA+ G V S A +
Sbjct: 71 NGKELNGSDDALGVLITHGTLVITAL------NNHTVGRYQCVARMPAGAVASVPATVTL 124
Query: 136 ATMSDFHVHPQATVG-EEGGVARFQCQI-HGLPKPLITWEKNRVPIDTDNERYTLLPKGV 193
A + DF + Q + +EG A C + PK + + + ++ Y ++P G
Sbjct: 125 ANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGN 184
Query: 194 LQITGLRAEDGGIFHCVASNIASIRISHGA---RLTVSGSGSGAYKEPAILVGPENLTLT 250
LQI ED G++ C A N + + RL V S + A + I+ PE T+
Sbjct: 185 LQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAAR---IIYPPEAQTII 241
Query: 251 VH--QTAVLECVATGNPRPIVSWSRLDGRPIGVEGIQVLGTGNLIISDVTVQHSGVYVCA 308
V Q+ +LECVA+G P P V+W++ G + L NL+I + + SG Y C
Sbjct: 242 VTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNKTRFL-LSNLLIDTTSEEDSGTYRCM 300
Query: 309 AN----RPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWL 364
A+ +PG V + V P E + P G +A TC+ +G PPP V WL
Sbjct: 301 ADNGVGQPGAAV---ILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWL 357
Query: 365 KNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAEGLP 424
+N L +RL L + +GPEDE +YQC+AEN GS+ A +L P
Sbjct: 358 RNAVPLISSQRLRLSRR--ALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRT----SRP 411
Query: 425 G-PPRNVRAVSVSSTEVRVSWSEPLANTKEIIGYVLHIRKAADPPELEYQEAVSKSTFQH 483
PR + +++ VS S+ L N +++ L Q A+ +
Sbjct: 412 SITPRLWQDAELATGTPPVSPSK-LGNPEQM---------------LRGQPALPR----- 450
Query: 484 LVSDLEPSTAYSFYIKAYTPRGASSASVPTLASTLGEAPAPPPL-SVRVLGSSSLQLLWE 542
P T+ G +S P A AP L S R + S +L+W
Sbjct: 451 ------PPTSV----------GPASPQCPGEKGQGAPAEAPIILSSPRTSKTDSYELVWR 494
Query: 543 PWPRLAQHEGGFK---LFY----RPASKTSFTGPIL-LPGTVSSYNLSQLDPTAVYEVKL 594
P +HEG + L+Y R + +S I +P L++LDP ++YEV++
Sbjct: 495 P-----RHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSLYEVEM 549
Query: 595 LAYNQHGDGNATV 607
AYN G+G +
Sbjct: 550 AAYNCAGEGQTAM 562
Score = 41.6 bits (96), Expect = 0.003
Identities = 45/218 (20%), Positives = 84/218 (38%), Gaps = 17/218 (7%)
Query: 424 PGPPRNVRAVSVSSTEVRVSWSEPLANTKEIIGYVLHIRKAADPPE-LEYQEAVSKSTFQ 482
P P + S T V V+W I + + +K + + A+ S
Sbjct: 606 PEAPDRPTISTASETSVYVTWIPRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLS 665
Query: 483 HLVSDLEPSTAYSFYIKAYTPRGASSASVPT-------LASTLGEAPAPPPLSV--RVLG 533
++ LE T+Y F ++A G S S P+ + + E P P +
Sbjct: 666 VEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVN 725
Query: 534 SSSLQLLWEPWPRLAQHEG--GFKLFYRPASKTSFTG--PILLPGTVSSYNLSQLDPTAV 589
+++ L W P + GF ++YRP + + ++ G +++S L P
Sbjct: 726 ETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQPETS 785
Query: 590 YEVKLLAYNQHGD---GNATVRFVSLRGASERTALSPP 624
Y++K+ +N+ G+ N + R +S + PP
Sbjct: 786 YDIKMQCFNEGGESEFSNVMICETKARKSSGQPGRLPP 823
Score = 34.3 bits (77), Expect = 0.48
Identities = 47/220 (21%), Positives = 79/220 (35%), Gaps = 36/220 (16%)
Query: 336 PQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRL------KNNNSTLTISG 389
P++ RP +TA E +VTW+ G P R+ K + L S
Sbjct: 606 PEAPDRPTISTA-------SETSVYVTWIPRGNGGFPIQSFRVEYKKLKKVGDWILATSA 658
Query: 390 IGPEDEAI------------YQCVAENSAGSSQASARLTVLWAEGLPGP--------PRN 429
I P ++ ++ A N G S+ SA G G P
Sbjct: 659 IPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYI 718
Query: 430 VRAVSVSSTEVRVSWSEPLA--NTKEIIGYVLHIRKAADPPELEYQ-EAVSKSTFQHLVS 486
+V+ T + + W A N I G+ ++ R + +Y+ + V + H +S
Sbjct: 719 TFTDAVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSIS 778
Query: 487 DLEPSTAYSFYIKAYTPRGASSASVPTLASTLGEAPAPPP 526
L+P T+Y ++ + G S S + T + P
Sbjct: 779 HLQPETSYDIKMQCFNEGGESEFSNVMICETKARKSSGQP 818
>gi|75709184 contactin 3 [Homo sapiens]
Length = 1028
Score = 177 bits (449), Expect = 3e-44
Identities = 168/612 (27%), Positives = 258/612 (42%), Gaps = 50/612 (8%)
Query: 53 AVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLA-NGSLMIRHFRLEPGGSPSD 111
A G + L+C G P +I WR++ LP S+ L +G L I +F+ E D
Sbjct: 239 AAKGSTVKLECFALGNPIPQINWRRSD-GLPFSSKIKLRKFSGVLEIPNFQQE------D 291
Query: 112 EGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGLPKPLIT 171
G YEC+A+N G V+R A + + E + ++C+ G PKP
Sbjct: 292 AGSYECIAENSRGKNVARGRLTYYAKPHWVQLIKDVEIAVEDSLY-WECRASGKPKPSYR 350
Query: 172 WEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLTVSGSG 231
W KN + E T + G L I+ L D G+F C+A N + S A L V S
Sbjct: 351 WLKNGAALVL--EERTQIENGALTISNLSVTDSGMFQCIAENKHGLVYS-SAELKVVASA 407
Query: 232 SGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEGIQVLGTGN 291
K P + + + V L+C +PR + SW + D E I +L G
Sbjct: 408 PDFSKNPM----KKLVQVQVGSLVSLDCKPRASPRALSSWKKGDVSVQEHERISLLNDGG 463
Query: 292 LIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTC 351
L I++VT +G Y C A + T LVV P P ++ G + + C
Sbjct: 464 LKIANVTKADAGTYTCMAENQFGKANGTTH--LVVTEPTRITLAPSNMDVSVGESVILPC 521
Query: 352 QAQGEPPPHV--TWLKNGQVLG---PGGHVRLKNNNST--LTISGIGPEDEAIYQCVAEN 404
Q Q +P + TW NG + G H +S+ L I I + Y C+ +
Sbjct: 522 QVQHDPLLDIIFTWYFNGALADFKKDGSHFEKVGGSSSGDLMIRNIQLKHSGKYVCMVQT 581
Query: 405 SAGSSQASARLTVLWAEGLPGPPRNVRAVSVSSTEVRVSWSEPLANTKEIIGYVLHIRKA 464
S ++A L V G PGPP NV+ ++ T ++SW E N +I Y + +A
Sbjct: 582 GVDSVSSAADLIV---RGSPGPPENVKVDEITDTTAQLSWKEGKDNHSPVISYSI---QA 635
Query: 465 ADPPELEYQ------EAVSKSTFQHLVSDLEPSTAYSFYIKAYTPRGASSASVPTLASTL 518
P + +Q E + T V +L P Y F + A G S+P+
Sbjct: 636 RTPFSVGWQTVTTVPEVIDGKTHTATVVELNPWVEYEFRVVASNKIGGGEPSLPSEKVRT 695
Query: 519 GEA-PAPPPLSVRVLGSSSLQLL--WEPWPRLAQH-EG-GFKLFYRPASKTSFTGPILLP 573
EA P PP V G S +L+ W+P P Q+ EG G+ + +RP T++ ++
Sbjct: 696 EEAVPEVPPSEVNGGGGSRSELVITWDPVPEELQNGEGFGYVVAFRPLGVTTWIQTVVTS 755
Query: 574 GTVSSY--NLSQLDPTAVYEVKLLAYNQHGDGNATVRFVSLRGASERTALSPPCDCRKEE 631
Y + P + YEVK+ YN G+G + ++ A E ++P +
Sbjct: 756 PDTPRYVFRNESIVPYSPYEVKVGVYNNKGEGPFS-PVTTVFSAEEEPTVAP-----SQV 809
Query: 632 AANQTSTTGIVI 643
+AN S++ I +
Sbjct: 810 SANSLSSSEIEV 821
Score = 148 bits (373), Expect = 2e-35
Identities = 119/390 (30%), Positives = 176/390 (45%), Gaps = 28/390 (7%)
Query: 44 FAVEPSDDVAVPG---QPIVLDCRVEGTPPVRITWRKNGVELPEST-HSTLLANGSLMIR 99
F EPS+ + G + I L C G P W+ NG ++ S H L G+L++
Sbjct: 28 FIKEPSNSIFPVGSEDKKITLHCEARGNPSPHYRWQLNGSDIDMSMEHRYKLNGGNLVV- 86
Query: 100 HFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVG-EEGGVARF 158
+ P + D G Y+C A N G +VSR+A++Q A + +F ++TV EG
Sbjct: 87 ---INPNRN-WDTGTYQCFATNSLGTIVSREAKLQFAYLENFKTKMRSTVSVREGQGVVL 142
Query: 159 QCQIHGLPKP-----LITWEKNRVP--IDTDNERYTLLPKGVLQITGLRAEDGGIFHCVA 211
C P P W N P ++ D+ R+ G L I+ + D G + CV
Sbjct: 143 LCG----PPPHSGELSYAWIFNEYPSFVEEDSRRFVSQETGHLYISKVEPSDVGNYTCVV 198
Query: 212 SNIASIRISHGAR--LTVSGSGSGAYKEPAILVG-PENLTLTVHQTAVLECVATGNPRPI 268
+++ + G+ L + G EP I V PE L T LEC A GNP P
Sbjct: 199 TSMVTNARVLGSPTPLVLRSDGVMGEYEPKIEVQFPETLPAAKGSTVKLECFALGNPIPQ 258
Query: 269 VSWSRLDGRPIGVEGIQVLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQA 328
++W R DG P + +G L I + + +G Y C A +R + A+GRL A
Sbjct: 259 INWRRSDGLPFSSKIKLRKFSGVLEIPNFQQEDAGSYECIAEN--SRGKNVARGRLTYYA 316
Query: 329 PAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTIS 388
+VQ + + + + C+A G+P P WLKNG L R + N LTIS
Sbjct: 317 KPHWVQLIKDVEIAVEDSLYWECRASGKPKPSYRWLKNGAALVL--EERTQIENGALTIS 374
Query: 389 GIGPEDEAIYQCVAENSAGSSQASARLTVL 418
+ D ++QC+AEN G +SA L V+
Sbjct: 375 NLSVTDSGMFQCIAENKHGLVYSSAELKVV 404
Score = 77.8 bits (190), Expect = 4e-14
Identities = 143/595 (24%), Positives = 228/595 (38%), Gaps = 76/595 (12%)
Query: 56 GQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRLEPGGSPSDEGDY 115
G + LDC+ +P +W+K V + E +LL +G L I + + +D G Y
Sbjct: 424 GSLVSLDCKPRASPRALSSWKKGDVSVQEHERISLLNDGGLKIANV------TKADAGTY 477
Query: 116 ECVAQNRFG-------LVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGLPKP 168
C+A+N+FG LVV+ RI A + +VGE + Q Q L
Sbjct: 478 TCMAENQFGKANGTTHLVVTEPTRITLAPSN-----MDVSVGESV-ILPCQVQHDPLLDI 531
Query: 169 LITWEKNRVPIDTDN-----ERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGA 223
+ TW N D E+ G L I ++ + G + C+ +S A
Sbjct: 532 IFTWYFNGALADFKKDGSHFEKVGGSSSGDLMIRNIQLKHSGKYVCMVQTGVD-SVSSAA 590
Query: 224 RLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEG 283
L V GS P V + +T T Q + E N P++S+S P V G
Sbjct: 591 DLIVRGSPG-----PPENVKVDEITDTTAQLSWKE--GKDNHSPVISYSIQARTPFSV-G 642
Query: 284 IQVLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRL---VVQAPAEFVQHPQSIS 340
Q + T +I T H+ V R A ++ P+E V+ +++
Sbjct: 643 WQTVTTVPEVIDGKT--HTATVVELNPWVEYEFRVVASNKIGGGEPSLPSEKVRTEEAVP 700
Query: 341 RPAGTTAMFTCQAQGEPPPHVTW------LKNGQVLGPGGHVRLKNNNSTLTIS------ 388
+ ++ E +TW L+NG+ G G V + T I
Sbjct: 701 EVPPSEVNGGGGSRSELV--ITWDPVPEELQNGE--GFGYVVAFRPLGVTTWIQTVVTSP 756
Query: 389 ----------GIGPEDEAIYQCVAENSAGSSQASARLTVLWAEGLPG-PPRNVRAVSVSS 437
I P + N+ G S TV AE P P V A S+SS
Sbjct: 757 DTPRYVFRNESIVPYSPYEVKVGVYNNKGEGPFSPVTTVFSAEEEPTVAPSQVSANSLSS 816
Query: 438 TEVRVSWSE---PLANTKEIIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPSTAY 494
+E+ VSW+ L+N ++GY + E + V+ + + L+ + AY
Sbjct: 817 SEIEVSWNTIPWKLSNG-HLLGYEVRYWNGGGKEESSSKMKVAGNETSARLRGLKSNLAY 875
Query: 495 SFYIKAYTPRGASSASVPTLASTLGEAPAPPPLSVRVLGSSSLQLL-WEPWPRLAQHE-- 551
++AY GA S +T P+ PP +V + + LL WE +
Sbjct: 876 YTAVRAYNSAGAGPFSATVNVTTKKTPPSQPPGNVVWNATDTKVLLNWEQVKAMENESEV 935
Query: 552 GGFKLFYRPASKTSFTGPILLPGTVSSYNLSQLDPTAVYEVKLLAYNQHGDGNAT 606
G+K+FYR +S+ + +L S+ + + + EVK A GDG ++
Sbjct: 936 TGYKVFYRTSSQNNV--QVLNTNKTSAELVLPIKEDYIIEVK--ATTDGGDGTSS 986
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 172 bits (436), Expect = 1e-42
Identities = 121/384 (31%), Positives = 177/384 (46%), Gaps = 22/384 (5%)
Query: 55 PGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRLEPGGSPSDEGD 114
PGQ +VL+C VE P +ITW ++G+ L E H+ G R +L+ S +D GD
Sbjct: 2405 PGQ-LVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERG----RFLQLQ-ALSTADSGD 2458
Query: 115 YECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGLPKPLITWEK 174
Y C A+N G S R++ T+ P A A CQ G+P PL++W K
Sbjct: 2459 YSCTARNAAGST-SVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRK 2517
Query: 175 NRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLTVSGSGSGA 234
+RVP+D + R+ +LP+G L+I + A+D G + C+ASN A G
Sbjct: 2518 DRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASN--------SAGSDRQGRDLRV 2569
Query: 235 YKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVE----GIQVLGTG 290
+ PAI P NLTLT H A+L C A+G+P+P+V W + DG+ + ++L +
Sbjct: 2570 LEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWK-DGQKLDFRLQQGAYRLLPSN 2628
Query: 291 NLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFT 350
L+++ Q S + C + R Q + V P + + T
Sbjct: 2629 ALLLTAPGPQDSAQFECVVSNEVGEAHRLYQ--VTVHVPPTIADDQTDFTVTMMAPVVLT 2686
Query: 351 CQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQ 410
C + G P P V+W K G LG G + + L I P Y C A NSAG +
Sbjct: 2687 CHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAH 2746
Query: 411 ASARLTVLWAEGLPGPPRNVRAVS 434
LTV + + P VRAV+
Sbjct: 2747 KHVFLTVQASPVVKPLPSVVRAVA 2770
Score = 157 bits (398), Expect = 3e-38
Identities = 124/385 (32%), Positives = 179/385 (46%), Gaps = 46/385 (11%)
Query: 47 EPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRLEPG 106
+P++ PG P+ L C +GTP ITW K+G L T L N S R R+
Sbjct: 2310 QPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQAL------TRLENNSRATRVLRVR-- 2361
Query: 107 GSPSDEGDYECVAQNRFGLV-VSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGL 165
D G Y C+A++ G + S + R+QA P+ VG G +C +
Sbjct: 2362 ----DAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAE 2417
Query: 166 PKPLITWEKNRVPIDTDNERYTLLPK--GVLQITGLRAEDGGIFHCVASNIASIRISHGA 223
P P ITW ++ + + D +T P+ LQ+ L D G + C A N A
Sbjct: 2418 PAPKITWHRDGIVLQED--AHTQFPERGRFLQLQALSTADSGDYSCTARNAA-------- 2467
Query: 224 RLTVSGSGSGAYK-----EPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRP 278
GS S A++ P I GP + ++V+QTA+L C A G P P+VSW R D P
Sbjct: 2468 -----GSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSW-RKDRVP 2521
Query: 279 IGVEG--IQVLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGR-LVVQAPAEFVQH 335
+ ++L G+L I V Q +G Y+C A+ R QGR L V P
Sbjct: 2522 LDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDR---QGRDLRVLEPPAIAPS 2578
Query: 336 PQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLG---PGGHVRLKNNNSTLTISGIGP 392
P +++ A T A+ C+A G P P V W K+GQ L G RL +N+ L ++ GP
Sbjct: 2579 PSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNA-LLLTAPGP 2637
Query: 393 EDEAIYQCVAENSAGSSQASARLTV 417
+D A ++CV N G + ++TV
Sbjct: 2638 QDSAQFECVVSNEVGEAHRLYQVTV 2662
Score = 152 bits (383), Expect = 2e-36
Identities = 114/398 (28%), Positives = 180/398 (45%), Gaps = 26/398 (6%)
Query: 48 PSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRLEPGG 107
PS AV + ++L C G P ITW+K G+ + + +L G L I H
Sbjct: 2763 PSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAH------A 2816
Query: 108 SPSDEGDYECVAQNRFGLVVSR-KARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGLP 166
SP D G+Y C+A+N G + + + +Q + + + +T EG A C+ G P
Sbjct: 2817 SPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTT--EGSHAFLPCKARGSP 2874
Query: 167 KPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLT 226
+P ITW+K+ P+ ++T+ P G L + L +D G + C A N R LT
Sbjct: 2875 EPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVG-RARRRVHLT 2933
Query: 227 VSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEGI-Q 285
+ P P + +L + L C A G+P P + W+ ++ RP+ EG+ +
Sbjct: 2934 I-------LVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWT-VNDRPV-TEGVSE 2984
Query: 286 VLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRL--VVQAPAEFVQHPQSISRPA 343
G L + V+ + SG YVC A RV RT V +AP + + P
Sbjct: 2985 QDGGSTLQRAAVSREDSGTYVCWAE---NRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPV 3041
Query: 344 GTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAE 403
G + C +G+P P + W+K+G L G H+R + N +LTI +D YQC+AE
Sbjct: 3042 GGSIQLDCVVRGDPVPDIHWIKDGLPL-RGSHLRHQLQNGSLTIHRTERDDAGRYQCLAE 3100
Query: 404 NSAGSSQASARLTVLWAEGLPGPPRNVRAVSVSSTEVR 441
N G ++ L + A P+++ S +R
Sbjct: 3101 NEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALR 3138
Score = 136 bits (342), Expect = 9e-32
Identities = 120/397 (30%), Positives = 169/397 (42%), Gaps = 40/397 (10%)
Query: 39 SAELAFAVE-----------PSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVEL-PEST 86
S +AF VE P+ +V+V Q +L C+ +G P ++WRK+ V L P S
Sbjct: 2469 STSVAFRVEIHTVPTIRSGPPAVNVSV-NQTALLPCQADGVPAPLVSWRKDRVPLDPRSP 2527
Query: 87 HSTLLANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKAR-IQAATMSDFHVHP 145
+L GSL I+ + D G Y C+A N G R+ R ++ P
Sbjct: 2528 RFEILPEGSLRIQPVLAQ------DAGHYLCLASNSAGS--DRQGRDLRVLEPPAIAPSP 2579
Query: 146 QATVGEEGGVARFQCQIHGLPKPLITWEKNRVPIDTDNER--YTLLPKGVLQITGLRAED 203
A C+ G PKPL+ W K+ +D ++ Y LLP L +T +D
Sbjct: 2580 SNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQD 2639
Query: 204 GGIFHCVASNIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATG 263
F CV SN + RL + P I + T+T+ VL C +TG
Sbjct: 2640 SAQFECVVSN----EVGEAHRLYQVT----VHVPPTIADDQTDFTVTMMAPVVLTCHSTG 2691
Query: 264 NPRPIVSWSRLDGRPIGVEG--IQVLGTGNLIISDVTVQHSGVYVCAA-NRPGTRVRRTA 320
P P VSWS+ G +G G +V +G L I H+G Y C+A N G +
Sbjct: 2692 IPAPTVSWSKA-GAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVF 2750
Query: 321 QGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKN 380
L VQA P + A + C+A G P P +TW K G + G ++
Sbjct: 2751 ---LTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLP 2807
Query: 381 NNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTV 417
L I+ PED Y C+A+NSAGS+ RL V
Sbjct: 2808 GGQ-LRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVV 2843
Score = 130 bits (328), Expect = 4e-30
Identities = 108/394 (27%), Positives = 180/394 (45%), Gaps = 41/394 (10%)
Query: 52 VAVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANG-SLMIRHFRLEPGGSPS 110
V+ PG+ + + C V G+PP+ ++W K+G+ LP S + L +G +L I +L +
Sbjct: 2133 VSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQL------A 2186
Query: 111 DEGDYECVAQNRFGLVVSR-KARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGLPKPL 169
D G + CVA + G+ ++Q + + V G + C+ G+P PL
Sbjct: 2187 DAGIFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPL 2246
Query: 170 ITWEKNRVPIDTDNERYTLLPKGV-LQITGLRAEDGGIFHCVASNIASIRISHGARLTVS 228
++W K+ P+ + + L +G LQ+ + A D G + CVA + A H +LTV
Sbjct: 2247 VSWMKDGEPLLSQS-----LEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRH-FQLTVM 2300
Query: 229 GSGSGAYKEPAILVG---PENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEGIQ 285
EP + P L+LT L C A G P+P ++W + DG + +
Sbjct: 2301 --------EPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHK-DG-----QALT 2346
Query: 286 VLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFV--QHPQSISRPA 343
L + + V+ +G+Y C A P + ++ + R VQAP V + P+ + A
Sbjct: 2347 RLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVR--VQAPPNIVGPRGPRFVVGLA 2404
Query: 344 GTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAE 403
+ C + EP P +TW ++G VL H + L + + D Y C A
Sbjct: 2405 PGQLVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTAR 2464
Query: 404 NSAGSSQASARLTVLWAEGL-PGPPRNVRAVSVS 436
N+AGS+ + R+ + + GPP AV+VS
Sbjct: 2465 NAAGSTSVAFRVEIHTVPTIRSGPP----AVNVS 2494
Score = 122 bits (307), Expect = 1e-27
Identities = 131/530 (24%), Positives = 209/530 (39%), Gaps = 75/530 (14%)
Query: 59 IVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRLEPGGSPSDEGDYECV 118
+ L+C PP I W K+G + S+ +L G L+ +++P SD G Y CV
Sbjct: 1466 LTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLL----QIQPT-QVSDSGRYLCV 1520
Query: 119 AQN-------RFGLVVSRKARIQAATMSDFHVHPQATVGEE---GGVARFQ--------- 159
A N F +++ Q + DF + EE GGV ++
Sbjct: 1521 ATNVAGEDDQDFNVLIQVPPMFQK--VGDFSAAFEILSREEEARGGVTEYREIVENNPAY 1578
Query: 160 --CQIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASI 217
C + +P P +TW + P+ +E L VLQI +RAE+ G + C ASN
Sbjct: 1579 LYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGE 1638
Query: 218 RISHGARLTVSGSGSGAYKEPAILVGP-----ENLTLTVHQTAVLECVATGNPRPIVSWS 272
H L ++ P +++G E +T+ T L+C A GNP P +SW
Sbjct: 1639 DWLHYELLVLT---------PPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWL 1689
Query: 273 RLDGRPIGVEG-IQVLGTGNLI-ISDVTVQHSGVYVCAA-NRPGTRVRRTAQGRLVVQAP 329
+ +G P +QVL G ++ +S V + Y+C A N+ G+ + L VQ P
Sbjct: 1690 Q-NGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFT---LRVQVP 1745
Query: 330 AEFVQHP-QSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTIS 388
+ ++ ++ C P P VTW K+ Q L G V L TL +
Sbjct: 1746 PRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLG 1805
Query: 389 GIGPEDEAIYQCVAENSAGSSQASARLTVLWAEGLPGPPRNV----------RAVSVSST 438
D +Y C A N+AG Q +L+VL PR +AV T
Sbjct: 1806 RARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCET 1865
Query: 439 ----EVRVSW---SEPLANTKEIIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPS 491
E V+W +PL ++ + E++ + K + VS++
Sbjct: 1866 DALPEPTVTWYKDGQPL-----VLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGE 1920
Query: 492 TAYSFYIKAYTPRGASSASVPTLASTLGEAPAPPPLSVRVLGSSSLQLLW 541
+F + P + T++ G +P L+ V G + + W
Sbjct: 1921 AVRTFTLTVQVPPTFENPKTETVSQVAG---SPLVLTCDVSGVPAPTVTW 1967
Score = 120 bits (302), Expect = 4e-27
Identities = 109/416 (26%), Positives = 170/416 (40%), Gaps = 56/416 (13%)
Query: 30 PAPSEGLGHSAELAFAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVE-LPESTHS 88
PAP LG A + + + G + L C G P ++ W K+ LP H
Sbjct: 213 PAPPSVLGAGAA-------QEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHL 265
Query: 89 TLLANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQAT 148
+ +G ++ R+ G DEG Y+CVA + G Q A VH T
Sbjct: 266 QVQEDGQVL----RIT-GSHVGDEGRYQCVAFSPAG---------QQARDFQLRVHAPPT 311
Query: 149 V---GEEGGVARFQ-------CQIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITG 198
+ E G VA + C+ G+P P ITW K+ + T + LQ+
Sbjct: 312 IWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGR 371
Query: 199 LRAEDGGIFHCVASNIA-----SIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQ 253
++ D G++ C ASN + R+ T+ G+G Y A+ P
Sbjct: 372 AQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRP--------- 422
Query: 254 TAVLECVATGNPRPIVSWSRLDGRPIGVEGIQVLGTGNLII--SDVTVQHSGVYVCAANR 311
LECVA G+P P +SW +G P+ L T ++ SG+Y C A+
Sbjct: 423 -VALECVARGHPSPTLSWHH-EGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASS 480
Query: 312 PGTRVRRTAQGRLVVQAPAEFV--QHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQV 369
P Q + VQ P + + + ++ G CQA G P P + WL+NG+
Sbjct: 481 PAGEA--VLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRP 538
Query: 370 LGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTV--LWAEGL 423
V++ + +TL I + + ++ C A N AG++ A ++V WA G+
Sbjct: 539 AEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGV 594
Score = 117 bits (293), Expect = 4e-26
Identities = 109/417 (26%), Positives = 160/417 (38%), Gaps = 40/417 (9%)
Query: 56 GQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRLEPGGSPSDEGDY 115
G P L C G P +I+WRK+G LP L + S + R L + EG Y
Sbjct: 986 GHPTSLSCECRGVPFPKISWRKDGQPLPGEGAG--LQHVSAVGRLLYLGQA-QLAQEGTY 1042
Query: 116 ECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEE---------GGVARFQCQIHGLP 166
C N G + HV PQ E GVA +C G P
Sbjct: 1043 TCECSNVVG-------NSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKP 1095
Query: 167 KPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLT 226
P +TWE++ P+ + L + +A G + CVA N+A R L+
Sbjct: 1096 PPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAG-RAERKFELS 1154
Query: 227 VSGSGSGAYKEPAILVGP----ENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPI--G 280
V P L+G N+T +H L C A G P P + W R + P+ G
Sbjct: 1155 VL--------VPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGE-EPVSPG 1205
Query: 281 VEGIQVLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSIS 340
+ + G L ++ Q SG+Y C A+ RR ++V E + I
Sbjct: 1206 EDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIK 1265
Query: 341 RPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQC 400
G TA C G P P +TW K+G+ L G + + L + Y C
Sbjct: 1266 VLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSC 1325
Query: 401 VAENSAGSSQASARLTVLWAEGLPGPPRNVRAVSVSSTEVRVSWSEPLANTKEIIGY 457
+A N+ G +L+VL A + G A + EV V+ + P++ E + +
Sbjct: 1326 IAANAVGEKTKHFQLSVLLAPTILG-----GAEDSADEEVTVTVNNPISLICEALAF 1377
Score = 115 bits (288), Expect = 2e-25
Identities = 112/401 (27%), Positives = 170/401 (42%), Gaps = 28/401 (6%)
Query: 27 LLLPAPSEGLGHSAELAFAVEPSDDVAVPGQPIV-LDCRVEGTPPVRITWRKNGVELPES 85
LL+ P LG + EL ++V V V L C G P I+W +NG+ S
Sbjct: 1645 LLVLTPPVILGDTEELV------EEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPS 1698
Query: 86 THSTLLANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSR-KARIQAATMSDFHVH 144
+L +G ++ +D Y CVA+N+ G R+Q
Sbjct: 1699 PRLQVLEDGQVL-----QVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDL 1753
Query: 145 PQATVGEEGGVARFQCQIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDG 204
Q T V+ C +H P P +TW K+ + E + L LQ+ R D
Sbjct: 1754 EQVTAILNSSVS-LPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDS 1812
Query: 205 GIFHCVASNIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLT-VHQTAVLECVATG 263
G++ C A N A R +L+V A+++ GP++ L V AVL C
Sbjct: 1813 GMYTCEALNAAG-RDQKLVQLSVLVPP--AFRQAPR--GPQDAVLVRVGDKAVLSCETDA 1867
Query: 264 NPRPIVSWSRLDGRPIGV-EGIQVLGTGN-LIISDVTVQHSGVYVCAANRPGTRVRRTAQ 321
P P V+W + DG+P+ + + Q L G L I + V G+Y C + RT
Sbjct: 1868 LPEPTVTWYK-DGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFT 1926
Query: 322 GRLVVQAPAEFVQHP--QSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLK 379
L VQ P F ++P +++S+ AG+ + TC G P P VTWLK+ + +
Sbjct: 1927 --LTVQVPPTF-ENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVV 1983
Query: 380 NNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTVLWA 420
+ L +S + P Y CVAEN+ ++ + VL A
Sbjct: 1984 SRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVA 2024
Score = 114 bits (285), Expect = 4e-25
Identities = 105/380 (27%), Positives = 150/380 (39%), Gaps = 34/380 (8%)
Query: 53 AVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLL-ANGSLMIRHFRLEPGGSPSD 111
A+ + L C V P +TW K+ L LL +L + RL SD
Sbjct: 1758 AILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARL------SD 1811
Query: 112 EGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQ----ATVGEEGGVARFQCQIHGLPK 167
G Y C A N G + ++ F P+ A + G A C+ LP+
Sbjct: 1812 SGMYTCEALNAAGRD-QKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPE 1870
Query: 168 PLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLTV 227
P +TW K+ P+ L L+I + D G++ C SN+A + LTV
Sbjct: 1871 PTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAV-RTFTLTV 1929
Query: 228 SGSGSGAYKEPAILVGPENLTLTVHQTA----VLECVATGNPRPIVSWSRLDGRPI---G 280
+ P P+ T TV Q A VL C +G P P V+W + D P+
Sbjct: 1930 --------QVPPTFENPK--TETVSQVAGSPLVLTCDVSGVPAPTVTWLK-DRMPVESSA 1978
Query: 281 VEGIQVLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSIS 340
V G+ G G L +S + +G Y C A R+ ++V +
Sbjct: 1979 VHGVVSRG-GRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHH 2037
Query: 341 RPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGP--GGHVRLKNNNSTLTISGIGPEDEAIY 398
G C+A G+PPP V WLK+G LG G H+R + +L + G+ D Y
Sbjct: 2038 VLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAY 2097
Query: 399 QCVAENSAGSSQASARLTVL 418
CVA N AG + VL
Sbjct: 2098 TCVAHNPAGEDARLHTVNVL 2117
Score = 112 bits (279), Expect = 2e-24
Identities = 142/553 (25%), Positives = 212/553 (38%), Gaps = 88/553 (15%)
Query: 38 HSAELAFAVEPSDDVAVPGQPIV-LDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSL 96
H+ + + +VAV +V L C G P ITW K+G LP ST G
Sbjct: 307 HAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGG-- 364
Query: 97 MIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGG-- 154
R +L S SD G Y C A N G + AT D +V P T+ GG
Sbjct: 365 --RQLQLGRAQS-SDAGVYTCKASNAVGAA-------EKATRLDVYVPP--TIEGAGGRP 412
Query: 155 ---------VARFQCQIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGG 205
+C G P P ++W +P+ NE VL++ G
Sbjct: 413 YVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSG 472
Query: 206 IFHCVASNIASIRI-SHGARLTVSGSGSGAYKEPAILV--GPENLTLTVHQTAVLECVAT 262
++ CVAS+ A + + + V P +LV G +T V Q L C A+
Sbjct: 473 LYSCVASSPAGEAVLQYSVEVQVP---------PQLLVAEGLGQVTTIVGQPLELPCQAS 523
Query: 263 GNPRPIVSWSRLDGRPIG-VEGIQVLGTGNLI-ISDVTVQHSGVYVC-AANRPGT---RV 316
G+P P + W + +GRP + G+QV G + I V + HSG++ C A N GT V
Sbjct: 524 GSPVPTIQWLQ-NGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEV 582
Query: 317 RRTAQGRL---VVQAPAEFV----QHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQV 369
+ G V++ P +H S A +PP W G +
Sbjct: 583 EVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSL 642
Query: 370 LG-PGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAEGLPGPPR 428
G P G + L I + DE IY C A N AG S+ L VL + P
Sbjct: 643 WGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPV 702
Query: 429 NVRAVSVSSTEVR----------VSW---SEPLAN----TKEIIGYVLHIRKAADPPELE 471
N + +S + VSW +P+++ T + G VL I +A
Sbjct: 703 NKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQA------- 755
Query: 472 YQEAVSKSTFQHLVSDLEPSTAYSFYIKAYTPRGAS---SASVPTLASTLGEAPAPPPLS 528
+ +++ + S++ ST + ++ P + S P L +T P L+
Sbjct: 756 --QLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNT------PVRLT 807
Query: 529 VRVLGSSSLQLLW 541
G+ S L+W
Sbjct: 808 CNATGAPSPTLMW 820
Score = 109 bits (272), Expect = 1e-23
Identities = 90/319 (28%), Positives = 132/319 (41%), Gaps = 17/319 (5%)
Query: 111 DEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGLPKPLI 170
DEG Y C A N G R+ ++ + P E +C G+P P +
Sbjct: 668 DEGIYTCAATNLAG-ESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDV 726
Query: 171 TWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIA-SIRISHGARLTVSG 229
+W K P+ + + VL+I + D G + CVASN+A S + +G R+ V
Sbjct: 727 SWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPP 786
Query: 230 SGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPI---GVEGIQV 286
P L GP + V+ L C ATG P P + W + DG P+ G G+QV
Sbjct: 787 R----ITLPPSLPGP----VLVNTPVRLTCNATGAPSPTLMWLK-DGNPVSPAGTPGLQV 837
Query: 287 LGTGNLI-ISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGT 345
G ++ ++ SG Y C A R+ L V P + ++S A
Sbjct: 838 FPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVV--LQVHMPPSILGEELNVSVVANE 895
Query: 346 TAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENS 405
+ CQ+ PPP ++W K+G+ L P V L + + L + D Y C A N
Sbjct: 896 SVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQ 955
Query: 406 AGSSQASARLTVLWAEGLP 424
AG S+ L V A P
Sbjct: 956 AGRSEKHYNLNVWVAPVFP 974
Score = 108 bits (271), Expect = 2e-23
Identities = 100/366 (27%), Positives = 146/366 (39%), Gaps = 26/366 (7%)
Query: 56 GQPIVLDCRVEGTPPVRITWRKNGVELPESTHS-TLLANGSLMIRHFRLEPGGSPSDEGD 114
G L C+ G+P ITW K+G + + T+ +G L++++ + D G
Sbjct: 2861 GSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQ------DAGT 2914
Query: 115 YECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGLPKPLITWEK 174
Y C A+N G R+ + + F P G +C G P P I W
Sbjct: 2915 YTCTAENAVGRA-RRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTV 2973
Query: 175 NRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLTVSGSGSGA 234
N P+ LQ + ED G + C A N R+ ++
Sbjct: 2974 NDRPVTEGVSEQD--GGSTLQRAAVSREDSGTYVCWAEN----RVGRTQAVSFVH----- 3022
Query: 235 YKEPAILVGP--ENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPI-GVEGIQVLGTGN 291
KE +L G L V + L+CV G+P P + W + DG P+ G L G+
Sbjct: 3023 VKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIK-DGLPLRGSHLRHQLQNGS 3081
Query: 292 LIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTC 351
L I +G Y C A ++ LV+Q+ F PQ ++ +G C
Sbjct: 3082 LTIHRTERDDAGRYQCLAENEMGVAKKVVI--LVLQSAPVFQVEPQDMTVRSGDDVALRC 3139
Query: 352 QAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQA 411
QA GEP P + WL+ GQ L +R + S L + + D Y CVA N GS+ A
Sbjct: 3140 QATGEPTPTIEWLQAGQPLRASRRLRTLPDGS-LWLENVETGDAGTYDCVAHNLLGSATA 3198
Query: 412 SARLTV 417
A L V
Sbjct: 3199 RAFLVV 3204
Score = 107 bits (266), Expect = 6e-23
Identities = 113/420 (26%), Positives = 168/420 (40%), Gaps = 43/420 (10%)
Query: 24 LLLLLLPAPSEGLGHSAELAFAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELP 83
L +LL P G SA+ V ++ PI L C P ITW K+G
Sbjct: 1340 LSVLLAPTILGGAEDSADEEVTVTVNN-------PISLICEALAFPSPNITWMKDGAPFE 1392
Query: 84 ESTHSTLL-ANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFH 142
S + LL L I + + E D G Y CV N G V S
Sbjct: 1393 ASRNIQLLPGTHGLQILNAQKE------DAGQYTCVVTNELGEAVKNYHVEVLIPPSISK 1446
Query: 143 VHPQATVGEE------GGVARFQCQIHGLPKPLITWEKNRVPIDTDNERYTLLPKG-VLQ 195
P VG + +C+ +P P I W K+ P+ T + R +L +G +LQ
Sbjct: 1447 DDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPV-TPSSRLQVLGEGRLLQ 1505
Query: 196 ITGLRAEDGGIFHCVASNIA-------SIRISHGARLTVSGSGSGAYK-----EPAILVG 243
I + D G + CVA+N+A ++ I G S A++ E A
Sbjct: 1506 IQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGV 1565
Query: 244 PENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEGIQVLGTGNLI-ISDVTVQHS 302
E + + A L C P P ++W R D + + VL G ++ I V +++
Sbjct: 1566 TEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENA 1625
Query: 303 GVYVC-AANRPGTRVRRTAQGRLVVQAPAEFV----QHPQSISRPAGTTAMFTCQAQGEP 357
G Y C A+N G L+V P + + + ++ A +T C A G P
Sbjct: 1626 GRYSCKASNEVG---EDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNP 1682
Query: 358 PPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTV 417
P ++WL+NG P +++ + L +S D A Y CVAEN AGS++ L V
Sbjct: 1683 VPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRV 1742
Score = 104 bits (260), Expect = 3e-22
Identities = 106/392 (27%), Positives = 151/392 (38%), Gaps = 42/392 (10%)
Query: 49 SDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRLEPGGS 108
+D V V G + L C G P ++W K+G E S L G + +LE G+
Sbjct: 2223 NDVVVVRGSLVELPCEARGVPLPLVSWMKDG----EPLLSQSLEQGPSL----QLEAVGA 2274
Query: 109 PSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGE----EGGVARFQCQIHG 164
D G Y CVA + G + Q M H+ E G C G
Sbjct: 2275 -GDSGTYSCVAVSEAG---EARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQG 2330
Query: 165 LPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGAR 224
P+P ITW K D + T L LR D G++ C+A + A I R
Sbjct: 2331 TPQPNITWHK-------DGQALTRLENNSRATRVLRVRDAGLYTCLAESPAG-AIEKSFR 2382
Query: 225 LTVSGSGSGAYKEPAILVGPENLTLTVHQT---AVLECVATGNPRPIVSWSRLDGRPIGV 281
+ V + P +VGP V VLEC P P ++W R DG +
Sbjct: 2383 VRV--------QAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHR-DGIVLQE 2433
Query: 282 EG-IQVLGTGNLI-ISDVTVQHSGVYVCAA-NRPGTRVRRTAQGRLVVQAPAEFVQHPQS 338
+ Q G + + ++ SG Y C A N G+ + R+ + P +
Sbjct: 2434 DAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGS---TSVAFRVEIHTVPTIRSGPPA 2490
Query: 339 ISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIY 398
++ TA+ CQA G P P V+W K+ L P +L I + +D Y
Sbjct: 2491 VNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHY 2550
Query: 399 QCVAENSAGSSQASARLTVLWAEGLPGPPRNV 430
C+A NSAGS + L VL + P N+
Sbjct: 2551 LCLASNSAGSDRQGRDLRVLEPPAIAPSPSNL 2582
Score = 103 bits (257), Expect = 6e-22
Identities = 96/391 (24%), Positives = 153/391 (39%), Gaps = 30/391 (7%)
Query: 41 ELAFAVEPSDDVAVPGQPIV-LDCRVEGTPPVRITWRKNGVELPESTHSTLLANG-SLMI 98
++A EP V+V + L+C G PP +TW ++G + L G SL +
Sbjct: 1066 QIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHV 1125
Query: 99 RHFRLEPGGSPSDEGDYECVAQNRFGLVVSR---KARIQAATMSDFHVHPQATVGEEGGV 155
+ G Y CVA+N G + + + D T +
Sbjct: 1126 ER------AQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPL 1179
Query: 156 ARFQCQIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIA 215
C+ G+P P I W + P+ + Y L +L++T + +D G++ C+ASN A
Sbjct: 1180 TLL-CEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEA 1238
Query: 216 S-IRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRL 274
R + + V S E I V QTA L C TG+P+P ++W +
Sbjct: 1239 GEARRNFSVEVLVPPSIENEDLEEVIKV-------LDGQTAHLMCNVTGHPQPKLTWFK- 1290
Query: 275 DGRPIGVEGIQVLGTGNLIIS--DVTVQHSGVYVC-AANRPGTRVRRTAQGRLVVQAPAE 331
DGRP+ + +++ + +G Y C AAN G + + V+ AP
Sbjct: 1291 DGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLS--VLLAPTI 1348
Query: 332 FVQHPQSISRPAGTTA----MFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTI 387
S T C+A P P++TW+K+G +++L L I
Sbjct: 1349 LGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQI 1408
Query: 388 SGIGPEDEAIYQCVAENSAGSSQASARLTVL 418
ED Y CV N G + + + VL
Sbjct: 1409 LNAQKEDAGQYTCVVTNELGEAVKNYHVEVL 1439
Score = 102 bits (253), Expect = 2e-21
Identities = 103/402 (25%), Positives = 163/402 (40%), Gaps = 37/402 (9%)
Query: 48 PSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRLEPGG 107
P + + + L+C G PP ++W K + T+ +G ++ R+E
Sbjct: 701 PVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVL----RIEQA- 755
Query: 108 SPSDEGDYECVAQN-------RFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQC 160
SD G Y CVA N R+GL V+ RI V V R C
Sbjct: 756 QLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPV-------RLTC 808
Query: 161 QIHGLPKPLITWEKNRVPID-TDNERYTLLPKG-VLQITGLRAEDGGIFHCVASNIASIR 218
G P P + W K+ P+ + P G VL + RA D G + CVA +
Sbjct: 809 NATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVG-E 867
Query: 219 ISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRP 278
L V + P+IL N+++ +++ LEC + P P++SW + DGRP
Sbjct: 868 DRQDVVLQV-------HMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWK-DGRP 919
Query: 279 IGVE-GIQVLGTGNLIISD-VTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHP 336
+ G+ + L+ D V +G Y C A R + + V AP ++
Sbjct: 920 LEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVWV-APVFPLRES 978
Query: 337 QSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGP---E 393
+++ G +C+ +G P P ++W K+GQ L PG L++ ++ + +G
Sbjct: 979 HTLTVREGHPTSLSCECRGVPFPKISWRKDGQPL-PGEGAGLQHVSAVGRLLYLGQAQLA 1037
Query: 394 DEAIYQCVAENSAGSSQASARLTVLWAEGLPGPPRNVRAVSV 435
E Y C N G+S +L V + GP VSV
Sbjct: 1038 QEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSV 1079
Score = 99.4 bits (246), Expect = 1e-20
Identities = 109/410 (26%), Positives = 155/410 (37%), Gaps = 52/410 (12%)
Query: 63 CRVEGTPPVRITWRKNGVELPESTHS--TLLANGSLMIRHFRLEPGGSPSDEGDYECVAQ 120
C GTP ++TWRK P +L GSL + SP+D GDYEC A
Sbjct: 24 CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASV------SPADSGDYECQAT 77
Query: 121 NRFGLVVSRKARIQAATMSDFHVHPQATV-GEEGGVARFQCQIHGLPKPLITWEKNR--- 176
N G R + S +A V G G +C +G P P I W K+
Sbjct: 78 NEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLV 137
Query: 177 -VPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLTVSGSGSGAY 235
VP+ + L G Q+ G R D G + + I+ R GS
Sbjct: 138 GVPLGWAGYGWDL---GWGQVGGHRLLDEG----QSLHFPRIQPGRSGRRGAQAGGSAQT 190
Query: 236 KEP--AILVG---------------PENLTLTVHQTAV--------LECVATGNPRPIVS 270
K P A L G P L Q + L+C +G P P V
Sbjct: 191 KAPWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVE 250
Query: 271 WSRLDGRPI--GVEGIQVLGTGNLI-ISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQ 327
W++ D +P+ G +QV G ++ I+ V G Y C A P + R Q R+
Sbjct: 251 WTK-DRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAP 309
Query: 328 APAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTI 387
++ C+A+G P P++TW K+G +L V L +
Sbjct: 310 PTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQL 369
Query: 388 SGIGPEDEAIYQCVAENSAGSSQASARLTVL---WAEGLPGPPRNVRAVS 434
D +Y C A N+ G+++ + RL V EG G P V+AV+
Sbjct: 370 GRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVA 419
Score = 93.2 bits (230), Expect = 9e-19
Identities = 113/446 (25%), Positives = 167/446 (37%), Gaps = 57/446 (12%)
Query: 56 GQPIVLDCRVEGTPPVRITWRKN----GVELPESTHSTLLANGSL---------MIRHF- 101
GQ + L+C G P I W K+ GV L + + L G + HF
Sbjct: 111 GQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFP 170
Query: 102 RLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHV----------HPQATVGE 151
R++PG S AQ + Q T F Q +G
Sbjct: 171 RIQPGRSGRRGAQAGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGL 230
Query: 152 EGGVARFQCQIHGLPKPLITWEKNRVPIDTDNERYTLLPKG-VLQITGLRAEDGGIFHCV 210
G QC G+P P + W K+R P+ + G VL+ITG D G + CV
Sbjct: 231 AGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCV 290
Query: 211 ASNIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLE--CVATGNPRPI 268
A + A + + +L V + P I E + V + +++ C A G P P
Sbjct: 291 AFSPAG-QQARDFQLRV-------HAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPN 342
Query: 269 VSWSRLDGR--PIGVEGIQVLGTGNLIISDVTVQHSGVYVC-AANRPGTRVRRTAQGRLV 325
++W + DG P + + G L + +GVY C A+N G + T RL
Sbjct: 343 ITWFK-DGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKAT---RLD 398
Query: 326 VQAPAEFV---QHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNN 382
V P P + AG C A+G P P ++W G + RL+ +
Sbjct: 399 VYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDG 458
Query: 383 STLTISGIGPEDEAIYQCVAENSAGSS--QASARLTV----LWAEGL------PGPPRNV 430
S L + G +Y CVA + AG + Q S + V L AEGL G P +
Sbjct: 459 SVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLEL 518
Query: 431 RAVSVSSTEVRVSWSEPLANTKEIIG 456
+ S + W + +E+ G
Sbjct: 519 PCQASGSPVPTIQWLQNGRPAEELAG 544
Score = 92.4 bits (228), Expect = 1e-18
Identities = 108/411 (26%), Positives = 154/411 (37%), Gaps = 52/411 (12%)
Query: 54 VPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGS-LMIRHFRLEPGGSPSDE 112
+ GQP+ L C+ G+P I W +NG E + + G+ L I H L+ G
Sbjct: 511 IVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGL---- 566
Query: 113 GDYECVAQNRFGLV-----VSRKARIQAATM--------------SDFHVHPQATVGEEG 153
+ C A N G VS + S F V
Sbjct: 567 --FACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGW 624
Query: 154 GVARFQCQIHGLPKPLITW-EKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVAS 212
G + G P W E +P+ Y+L P LQI + D GI+ C A+
Sbjct: 625 GAHPKPPLVEGWCSPGSLWGEPTGIPV-----AYSLPPP--LQIEKVDLRDEGIYTCAAT 677
Query: 213 NIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWS 272
N+A A + P I GP N + + + LEC+A+G P P VSW
Sbjct: 678 NLAGESKREVALKVLV--------PPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWF 729
Query: 273 RLDGRPIGVEGIQVLGTGNLI-ISDVTVQHSGVYVC-AANRPGTRVRRTAQGRLVVQAPA 330
+ G+ V G ++ I + +G Y C A+N G+ R L V P
Sbjct: 730 KGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYG---LRVNVPP 786
Query: 331 EFVQHPQSISRPA--GTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLK--NNNSTLT 386
+ P S+ P T TC A G P P + WLK+G + P G L+ LT
Sbjct: 787 R-ITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLT 845
Query: 387 ISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAEGLPGPPRNVRAVSVSS 437
++ D Y CVA ++ G + L V + G NV V+ S
Sbjct: 846 LASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANES 896
Score = 83.2 bits (204), Expect = 9e-16
Identities = 89/304 (29%), Positives = 124/304 (40%), Gaps = 47/304 (15%)
Query: 148 TVGEEGGVARFQCQIHGLPKPLITWEKNRVPIDTDNER-YTLLPKGVLQITGLRAEDGGI 206
TVG E G C HG PKP +TW K + +L +G L + + D G
Sbjct: 16 TVGLEAG----GCGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGD 71
Query: 207 FHCVASNIASIRISHGARLTVSGSGSGAYKEPAILVGPE--NLTLTVHQTAVLECVATGN 264
+ C A+N S A+L V Y P+I N++ Q+ LEC A G
Sbjct: 72 YECQATNEVG-STSRRAKLVV-------YVPPSIREDGRKANVSGMAGQSLTLECDANGF 123
Query: 265 PRPIVSW---SRLDGRPIGVEGI-QVLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTA 320
P P + W ++L G P+G G LG G + + + ++ +PG RR A
Sbjct: 124 PVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHF-PRIQPGRSGRRGA 182
Query: 321 Q--GRLVVQAP-----AEFVQHP-------------------QSISRPAGTTAMFTCQAQ 354
Q G +AP A F Q P Q + AG C
Sbjct: 183 QAGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTS 242
Query: 355 GEPPPHVTWLKNGQVLGPGG-HVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASA 413
G P P V W K+ Q + PGG H++++ + L I+G DE YQCVA + AG
Sbjct: 243 GVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDF 302
Query: 414 RLTV 417
+L V
Sbjct: 303 QLRV 306
Score = 81.6 bits (200), Expect = 3e-15
Identities = 73/274 (26%), Positives = 111/274 (40%), Gaps = 30/274 (10%)
Query: 44 FAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRL 103
F P D G + L C G+P RI W N + E GS + R
Sbjct: 2940 FTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQ--DGGSTLQR---- 2993
Query: 104 EPGGSPSDEGDYECVAQNRFG------LVVSRKARIQAATMSDFHVHPQATVGEEGGVAR 157
S D G Y C A+NR G V ++A + + V P GG +
Sbjct: 2994 -AAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEP------VGGSIQ 3046
Query: 158 FQCQIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASI 217
C + G P P I W K+ +P+ + R+ L G L I +D G + C+A N +
Sbjct: 3047 LDCVVRGDPVPDIHWIKDGLPLRGSHLRHQ-LQNGSLTIHRTERDDAGRYQCLAEN--EM 3103
Query: 218 RISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGR 277
++ + V S P V P+++T+ L C ATG P P + W + G+
Sbjct: 3104 GVAKKVVILVLQSA------PVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQA-GQ 3156
Query: 278 PI-GVEGIQVLGTGNLIISDVTVQHSGVYVCAAN 310
P+ ++ L G+L + +V +G Y C A+
Sbjct: 3157 PLRASRRLRTLPDGSLWLENVETGDAGTYDCVAH 3190
Score = 48.5 bits (114), Expect = 2e-05
Identities = 30/86 (34%), Positives = 39/86 (45%), Gaps = 6/86 (6%)
Query: 44 FAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRL 103
F VEP D G + L C+ G P I W + G L S L +GSL + + +
Sbjct: 3120 FQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLEN--V 3177
Query: 104 EPGGSPSDEGDYECVAQNRFGLVVSR 129
E G D G Y+CVA N G +R
Sbjct: 3178 ETG----DAGTYDCVAHNLLGSATAR 3199
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 172 bits (436), Expect = 1e-42
Identities = 121/384 (31%), Positives = 177/384 (46%), Gaps = 22/384 (5%)
Query: 55 PGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRLEPGGSPSDEGD 114
PGQ +VL+C VE P +ITW ++G+ L E H+ G R +L+ S +D GD
Sbjct: 3596 PGQ-LVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERG----RFLQLQ-ALSTADSGD 3649
Query: 115 YECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGLPKPLITWEK 174
Y C A+N G S R++ T+ P A A CQ G+P PL++W K
Sbjct: 3650 YSCTARNAAGST-SVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRK 3708
Query: 175 NRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLTVSGSGSGA 234
+RVP+D + R+ +LP+G L+I + A+D G + C+ASN A G
Sbjct: 3709 DRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASN--------SAGSDRQGRDLRV 3760
Query: 235 YKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVE----GIQVLGTG 290
+ PAI P NLTLT H A+L C A+G+P+P+V W + DG+ + ++L +
Sbjct: 3761 LEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWK-DGQKLDFRLQQGAYRLLPSN 3819
Query: 291 NLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFT 350
L+++ Q S + C + R Q + V P + + T
Sbjct: 3820 ALLLTAPGPQDSAQFECVVSNEVGEAHRLYQ--VTVHVPPTIADDQTDFTVTMMAPVVLT 3877
Query: 351 CQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQ 410
C + G P P V+W K G LG G + + L I P Y C A NSAG +
Sbjct: 3878 CHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAH 3937
Query: 411 ASARLTVLWAEGLPGPPRNVRAVS 434
LTV + + P VRAV+
Sbjct: 3938 KHVFLTVQASPVVKPLPSVVRAVA 3961
Score = 157 bits (398), Expect = 3e-38
Identities = 124/385 (32%), Positives = 179/385 (46%), Gaps = 46/385 (11%)
Query: 47 EPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRLEPG 106
+P++ PG P+ L C +GTP ITW K+G L T L N S R R+
Sbjct: 3501 QPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQAL------TRLENNSRATRVLRVR-- 3552
Query: 107 GSPSDEGDYECVAQNRFGLV-VSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGL 165
D G Y C+A++ G + S + R+QA P+ VG G +C +
Sbjct: 3553 ----DAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAE 3608
Query: 166 PKPLITWEKNRVPIDTDNERYTLLPK--GVLQITGLRAEDGGIFHCVASNIASIRISHGA 223
P P ITW ++ + + D +T P+ LQ+ L D G + C A N A
Sbjct: 3609 PAPKITWHRDGIVLQED--AHTQFPERGRFLQLQALSTADSGDYSCTARNAA-------- 3658
Query: 224 RLTVSGSGSGAYK-----EPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRP 278
GS S A++ P I GP + ++V+QTA+L C A G P P+VSW R D P
Sbjct: 3659 -----GSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSW-RKDRVP 3712
Query: 279 IGVEG--IQVLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGR-LVVQAPAEFVQH 335
+ ++L G+L I V Q +G Y+C A+ R QGR L V P
Sbjct: 3713 LDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDR---QGRDLRVLEPPAIAPS 3769
Query: 336 PQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLG---PGGHVRLKNNNSTLTISGIGP 392
P +++ A T A+ C+A G P P V W K+GQ L G RL +N+ L ++ GP
Sbjct: 3770 PSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNA-LLLTAPGP 3828
Query: 393 EDEAIYQCVAENSAGSSQASARLTV 417
+D A ++CV N G + ++TV
Sbjct: 3829 QDSAQFECVVSNEVGEAHRLYQVTV 3853
Score = 152 bits (383), Expect = 2e-36
Identities = 114/398 (28%), Positives = 180/398 (45%), Gaps = 26/398 (6%)
Query: 48 PSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRLEPGG 107
PS AV + ++L C G P ITW+K G+ + + +L G L I H
Sbjct: 3954 PSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAH------A 4007
Query: 108 SPSDEGDYECVAQNRFGLVVSR-KARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGLP 166
SP D G+Y C+A+N G + + + +Q + + + +T EG A C+ G P
Sbjct: 4008 SPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTT--EGSHAFLPCKARGSP 4065
Query: 167 KPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLT 226
+P ITW+K+ P+ ++T+ P G L + L +D G + C A N R LT
Sbjct: 4066 EPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVG-RARRRVHLT 4124
Query: 227 VSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEGI-Q 285
+ P P + +L + L C A G+P P + W+ ++ RP+ EG+ +
Sbjct: 4125 I-------LVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWT-VNDRPV-TEGVSE 4175
Query: 286 VLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRL--VVQAPAEFVQHPQSISRPA 343
G L + V+ + SG YVC A RV RT V +AP + + P
Sbjct: 4176 QDGGSTLQRAAVSREDSGTYVCWAE---NRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPV 4232
Query: 344 GTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAE 403
G + C +G+P P + W+K+G L G H+R + N +LTI +D YQC+AE
Sbjct: 4233 GGSIQLDCVVRGDPVPDIHWIKDGLPL-RGSHLRHQLQNGSLTIHRTERDDAGRYQCLAE 4291
Query: 404 NSAGSSQASARLTVLWAEGLPGPPRNVRAVSVSSTEVR 441
N G ++ L + A P+++ S +R
Sbjct: 4292 NEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALR 4329
Score = 137 bits (344), Expect = 5e-32
Identities = 124/412 (30%), Positives = 182/412 (44%), Gaps = 40/412 (9%)
Query: 48 PSDDVAV-PGQPIVLDCRVEGTPPVRITWRKNGVELPEST-HSTLLANGSLMIRHFRLEP 105
P+ +V V PG+ VL CRV G P +TW ++ LP ST LA+ SL I
Sbjct: 522 PAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEI------S 575
Query: 106 GGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGL 165
G P+D G Y+CVA N G V + +H + +G + C G
Sbjct: 576 GIIPTDGGRYQCVASNANG-VTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGY 634
Query: 166 PKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARL 225
P P I+W + + D+ R + +G L I G+ ED G + C A+N
Sbjct: 635 PTPHISWSRESQALQEDS-RIHVDAQGTLIIQGVAPEDAGNYSCQATNEVG--------- 684
Query: 226 TVSGSGSGAYKEPAILVGPENLTL-TVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEGI 284
T + + Y +P + + L V + AVL C A+G P P V W R G +
Sbjct: 685 TDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYR--GGLEMILAP 742
Query: 285 QVLGTGNLIISDVTVQHSGVYVC-AANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPA 343
+ +G L I + +G Y C A N G +A+ +L V + + P+ ++
Sbjct: 743 EGSSSGKLRIPAAQERDAGTYTCRAVNELGD---ASAEIQLAVGHAPQLTELPRDVTVEL 799
Query: 344 GTTAMFTCQAQGEPPPHVTWLKN-----GQVLGPGGHVRLKNNNS-TLTISGIGPEDEAI 397
G +A+ C+A G PPP VTW + G LG G R + +S L + PED+A
Sbjct: 800 GRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAP 859
Query: 398 YQCVAENSAGSSQASARLTVLWAEGLPGPPRNVRAVSVSSTEVRVSWSEPLA 449
Y C A N G QA ARL V PP+ ++ S+ VRV +P++
Sbjct: 860 YVCEARNVFGKVQAEARLIVTG----HAPPQ----IASSAPTVRVLEGQPVS 903
Score = 136 bits (342), Expect = 9e-32
Identities = 120/397 (30%), Positives = 169/397 (42%), Gaps = 40/397 (10%)
Query: 39 SAELAFAVE-----------PSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVEL-PEST 86
S +AF VE P+ +V+V Q +L C+ +G P ++WRK+ V L P S
Sbjct: 3660 STSVAFRVEIHTVPTIRSGPPAVNVSV-NQTALLPCQADGVPAPLVSWRKDRVPLDPRSP 3718
Query: 87 HSTLLANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKAR-IQAATMSDFHVHP 145
+L GSL I+ + D G Y C+A N G R+ R ++ P
Sbjct: 3719 RFEILPEGSLRIQPVLAQ------DAGHYLCLASNSAGS--DRQGRDLRVLEPPAIAPSP 3770
Query: 146 QATVGEEGGVARFQCQIHGLPKPLITWEKNRVPIDTDNER--YTLLPKGVLQITGLRAED 203
A C+ G PKPL+ W K+ +D ++ Y LLP L +T +D
Sbjct: 3771 SNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQD 3830
Query: 204 GGIFHCVASNIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATG 263
F CV SN + RL + P I + T+T+ VL C +TG
Sbjct: 3831 SAQFECVVSN----EVGEAHRLYQVT----VHVPPTIADDQTDFTVTMMAPVVLTCHSTG 3882
Query: 264 NPRPIVSWSRLDGRPIGVEG--IQVLGTGNLIISDVTVQHSGVYVCAA-NRPGTRVRRTA 320
P P VSWS+ G +G G +V +G L I H+G Y C+A N G +
Sbjct: 3883 IPAPTVSWSKA-GAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVF 3941
Query: 321 QGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKN 380
L VQA P + A + C+A G P P +TW K G + G ++
Sbjct: 3942 ---LTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLP 3998
Query: 381 NNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTV 417
L I+ PED Y C+A+NSAGS+ RL V
Sbjct: 3999 GGQ-LRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVV 4034
Score = 130 bits (328), Expect = 4e-30
Identities = 108/394 (27%), Positives = 180/394 (45%), Gaps = 41/394 (10%)
Query: 52 VAVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANG-SLMIRHFRLEPGGSPS 110
V+ PG+ + + C V G+PP+ ++W K+G+ LP S + L +G +L I +L +
Sbjct: 3324 VSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQL------A 3377
Query: 111 DEGDYECVAQNRFGLVVSR-KARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGLPKPL 169
D G + CVA + G+ ++Q + + V G + C+ G+P PL
Sbjct: 3378 DAGIFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPL 3437
Query: 170 ITWEKNRVPIDTDNERYTLLPKGV-LQITGLRAEDGGIFHCVASNIASIRISHGARLTVS 228
++W K+ P+ + + L +G LQ+ + A D G + CVA + A H +LTV
Sbjct: 3438 VSWMKDGEPLLSQS-----LEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRH-FQLTVM 3491
Query: 229 GSGSGAYKEPAILVG---PENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEGIQ 285
EP + P L+LT L C A G P+P ++W + DG + +
Sbjct: 3492 --------EPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHK-DG-----QALT 3537
Query: 286 VLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFV--QHPQSISRPA 343
L + + V+ +G+Y C A P + ++ + R VQAP V + P+ + A
Sbjct: 3538 RLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVR--VQAPPNIVGPRGPRFVVGLA 3595
Query: 344 GTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAE 403
+ C + EP P +TW ++G VL H + L + + D Y C A
Sbjct: 3596 PGQLVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTAR 3655
Query: 404 NSAGSSQASARLTVLWAEGL-PGPPRNVRAVSVS 436
N+AGS+ + R+ + + GPP AV+VS
Sbjct: 3656 NAAGSTSVAFRVEIHTVPTIRSGPP----AVNVS 3685
Score = 124 bits (311), Expect = 4e-28
Identities = 122/436 (27%), Positives = 173/436 (39%), Gaps = 76/436 (17%)
Query: 37 GHSAELAFAVEPSDDVAVPGQPIVLDCRV-EGTPPVRITWRKNGVELPESTHSTLLANGS 95
GH+ + P+ V + GQP+ L C V G P W K+G LP + ++ A+GS
Sbjct: 881 GHAPPQIASSAPTVRV-LEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGS 939
Query: 96 LMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQAT--VGEEG 153
L + E G Y CVA N G S+ ++ +HP AT + EG
Sbjct: 940 LHLDRALQEHAGR------YSCVATNTAG---SQHRDVELVVQVPPRIHPTATHHITNEG 990
Query: 154 GVARFQCQIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASN 213
A C G+P P ITW K + + Y + +G L I A+D G + C A+N
Sbjct: 991 VPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATN 1050
Query: 214 IASIRISHGARLTVS-----------------------------------------GSGS 232
S RL+V+ GS S
Sbjct: 1051 TVGFS-SQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSAS 1109
Query: 233 -----GAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEGIQVL 287
G P + GP L + V + L CVA GNP P +SWS+ DG + G Q
Sbjct: 1110 HRYVLGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSK-DGVVLQGRGPQ-- 1166
Query: 288 GTGNLIISDVTVQHSGVYVC-AANRPGTRVRRTAQGRLVVQAPAEFVQHPQS--ISRPAG 344
G++ + + +G Y C A+N G L V P + S + R AG
Sbjct: 1167 --GSVHFAAIRTSDAGRYRCEASNSAGVDAWEV---ELRVLEPPHWGADETSGLLERVAG 1221
Query: 345 TTAMFTCQAQGEPPPHVTWLK---NGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCV 401
A C A+G P P VTW K + + G G L+ +L ++ + P D Y+C
Sbjct: 1222 ENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLE--EGSLFLASVSPADSGDYECQ 1279
Query: 402 AENSAGSSQASARLTV 417
A N GS+ A+L V
Sbjct: 1280 ATNEVGSTSRRAKLVV 1295
Score = 122 bits (307), Expect = 1e-27
Identities = 131/530 (24%), Positives = 209/530 (39%), Gaps = 75/530 (14%)
Query: 59 IVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRLEPGGSPSDEGDYECV 118
+ L+C PP I W K+G + S+ +L G L+ +++P SD G Y CV
Sbjct: 2657 LTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLL----QIQPT-QVSDSGRYLCV 2711
Query: 119 AQN-------RFGLVVSRKARIQAATMSDFHVHPQATVGEE---GGVARFQ--------- 159
A N F +++ Q + DF + EE GGV ++
Sbjct: 2712 ATNVAGEDDQDFNVLIQVPPMFQK--VGDFSAAFEILSREEEARGGVTEYREIVENNPAY 2769
Query: 160 --CQIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASI 217
C + +P P +TW + P+ +E L VLQI +RAE+ G + C ASN
Sbjct: 2770 LYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGE 2829
Query: 218 RISHGARLTVSGSGSGAYKEPAILVGP-----ENLTLTVHQTAVLECVATGNPRPIVSWS 272
H L ++ P +++G E +T+ T L+C A GNP P +SW
Sbjct: 2830 DWLHYELLVLT---------PPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWL 2880
Query: 273 RLDGRPIGVEG-IQVLGTGNLI-ISDVTVQHSGVYVCAA-NRPGTRVRRTAQGRLVVQAP 329
+ +G P +QVL G ++ +S V + Y+C A N+ G+ + L VQ P
Sbjct: 2881 Q-NGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFT---LRVQVP 2936
Query: 330 AEFVQHP-QSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTIS 388
+ ++ ++ C P P VTW K+ Q L G V L TL +
Sbjct: 2937 PRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLG 2996
Query: 389 GIGPEDEAIYQCVAENSAGSSQASARLTVLWAEGLPGPPRNV----------RAVSVSST 438
D +Y C A N+AG Q +L+VL PR +AV T
Sbjct: 2997 RARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCET 3056
Query: 439 ----EVRVSW---SEPLANTKEIIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPS 491
E V+W +PL ++ + E++ + K + VS++
Sbjct: 3057 DALPEPTVTWYKDGQPL-----VLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGE 3111
Query: 492 TAYSFYIKAYTPRGASSASVPTLASTLGEAPAPPPLSVRVLGSSSLQLLW 541
+F + P + T++ G +P L+ V G + + W
Sbjct: 3112 AVRTFTLTVQVPPTFENPKTETVSQVAG---SPLVLTCDVSGVPAPTVTW 3158
Score = 121 bits (303), Expect = 3e-27
Identities = 110/421 (26%), Positives = 173/421 (41%), Gaps = 58/421 (13%)
Query: 25 LLLLLPAPSEGLGHSAELAFAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVE-LP 83
LL+L P G G + E+ + + G + L C G P ++ W K+ LP
Sbjct: 1401 LLVLTPPSVLGAGAAQEV---------LGLAGADVELQCWTSGVPTPQVEWTKDRQPVLP 1451
Query: 84 ESTHSTLLANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHV 143
H + +G ++ R+ G DEG Y+CVA + G Q A V
Sbjct: 1452 GGPHLQVQEDGQVL----RIT-GSHVGDEGRYQCVAFSPAG---------QQARDFQLRV 1497
Query: 144 HPQATV---GEEGGVARFQ-------CQIHGLPKPLITWEKNRVPIDTDNERYTLLPKGV 193
H T+ E G VA + C+ G+P P ITW K+ + T +
Sbjct: 1498 HAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQ 1557
Query: 194 LQITGLRAEDGGIFHCVASNIA-----SIRISHGARLTVSGSGSGAYKEPAILVGPENLT 248
LQ+ ++ D G++ C ASN + R+ T+ G+G Y A+ P
Sbjct: 1558 LQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRP---- 1613
Query: 249 LTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEGIQVLGTGNLII--SDVTVQHSGVYV 306
LECVA G+P P +SW +G P+ L T ++ SG+Y
Sbjct: 1614 ------VALECVARGHPSPTLSWHH-EGLPVAESNESRLETDGSVLRLESPGEASSGLYS 1666
Query: 307 CAANRPGTRVRRTAQGRLVVQAPAEFV--QHPQSISRPAGTTAMFTCQAQGEPPPHVTWL 364
C A+ P Q + VQ P + + + ++ G CQA G P P + WL
Sbjct: 1667 CVASSPAGEA--VLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWL 1724
Query: 365 KNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTV--LWAEG 422
+NG+ V++ + +TL I + + ++ C A N AG++ A ++V WA G
Sbjct: 1725 QNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPG 1784
Query: 423 L 423
+
Sbjct: 1785 V 1785
Score = 117 bits (293), Expect = 4e-26
Identities = 109/417 (26%), Positives = 160/417 (38%), Gaps = 40/417 (9%)
Query: 56 GQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRLEPGGSPSDEGDY 115
G P L C G P +I+WRK+G LP L + S + R L + EG Y
Sbjct: 2177 GHPTSLSCECRGVPFPKISWRKDGQPLPGEGAG--LQHVSAVGRLLYLGQA-QLAQEGTY 2233
Query: 116 ECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEE---------GGVARFQCQIHGLP 166
C N G + HV PQ E GVA +C G P
Sbjct: 2234 TCECSNVVG-------NSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKP 2286
Query: 167 KPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLT 226
P +TWE++ P+ + L + +A G + CVA N+A R L+
Sbjct: 2287 PPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAG-RAERKFELS 2345
Query: 227 VSGSGSGAYKEPAILVGP----ENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPI--G 280
V P L+G N+T +H L C A G P P + W R + P+ G
Sbjct: 2346 VL--------VPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGE-EPVSPG 2396
Query: 281 VEGIQVLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSIS 340
+ + G L ++ Q SG+Y C A+ RR ++V E + I
Sbjct: 2397 EDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIK 2456
Query: 341 RPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQC 400
G TA C G P P +TW K+G+ L G + + L + Y C
Sbjct: 2457 VLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSC 2516
Query: 401 VAENSAGSSQASARLTVLWAEGLPGPPRNVRAVSVSSTEVRVSWSEPLANTKEIIGY 457
+A N+ G +L+VL A + G A + EV V+ + P++ E + +
Sbjct: 2517 IAANAVGEKTKHFQLSVLLAPTILG-----GAEDSADEEVTVTVNNPISLICEALAF 2568
Score = 115 bits (289), Expect = 1e-25
Identities = 107/386 (27%), Positives = 156/386 (40%), Gaps = 68/386 (17%)
Query: 90 LLANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQATV 149
LL +GSL + ++ D G YEC A N G R + V PQ
Sbjct: 1078 LLPSGSLRLAQVQV------GDSGHYECTASNPAGSASHRY-------VLGVQVPPQVQP 1124
Query: 150 GEE------GGVARFQCQIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAED 203
G G C G P+P ++W K+ V + P+G + +R D
Sbjct: 1125 GPRVLKVLVGEALDLNCVAEGNPEPQLSWSKDGVVLQGRG------PQGSVHFAAIRTSD 1178
Query: 204 GGIFHCVASNIASIRISHGARLTVSGSGSGAYKEPAIL--VGPENLTLTVHQTAVLECVA 261
G + C ASN A + + GA + +L V EN A L C A
Sbjct: 1179 AGRYRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLERVAGEN--------ASLPCPA 1230
Query: 262 TGNPRPIVSWSR------LDGRPIGVEGIQVLGTGNLIISDVTVQHSGVYVC-AANRPGT 314
G P+P V+W + L G+P G+ VL G+L ++ V+ SG Y C A N G+
Sbjct: 1231 RGTPKPQVTWRKGPSSEPLHGQP----GVAVLEEGSLFLASVSPADSGDYECQATNEVGS 1286
Query: 315 RVRRTAQGRLVVQAPAEFVQHPQ--SISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGP 372
RR +LVV P + + ++S AG + C A G P P + WLK+ Q++G
Sbjct: 1287 TSRRA---KLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGV 1343
Query: 373 ----------------GGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLT 416
GGH RL + +L I D +Y C AEN AG++Q L
Sbjct: 1344 PLGWAGYGWDLGWGQVGGH-RLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLL 1402
Query: 417 VLWAEGLPGPPRNVRAVSVSSTEVRV 442
VL + G + ++ +V +
Sbjct: 1403 VLTPPSVLGAGAAQEVLGLAGADVEL 1428
Score = 115 bits (288), Expect = 2e-25
Identities = 112/401 (27%), Positives = 170/401 (42%), Gaps = 28/401 (6%)
Query: 27 LLLPAPSEGLGHSAELAFAVEPSDDVAVPGQPIV-LDCRVEGTPPVRITWRKNGVELPES 85
LL+ P LG + EL ++V V V L C G P I+W +NG+ S
Sbjct: 2836 LLVLTPPVILGDTEELV------EEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPS 2889
Query: 86 THSTLLANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSR-KARIQAATMSDFHVH 144
+L +G ++ +D Y CVA+N+ G R+Q
Sbjct: 2890 PRLQVLEDGQVL-----QVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDL 2944
Query: 145 PQATVGEEGGVARFQCQIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDG 204
Q T V+ C +H P P +TW K+ + E + L LQ+ R D
Sbjct: 2945 EQVTAILNSSVS-LPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDS 3003
Query: 205 GIFHCVASNIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLT-VHQTAVLECVATG 263
G++ C A N A R +L+V A+++ GP++ L V AVL C
Sbjct: 3004 GMYTCEALNAAG-RDQKLVQLSVLVPP--AFRQAPR--GPQDAVLVRVGDKAVLSCETDA 3058
Query: 264 NPRPIVSWSRLDGRPIGV-EGIQVLGTGN-LIISDVTVQHSGVYVCAANRPGTRVRRTAQ 321
P P V+W + DG+P+ + + Q L G L I + V G+Y C + RT
Sbjct: 3059 LPEPTVTWYK-DGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFT 3117
Query: 322 GRLVVQAPAEFVQHP--QSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLK 379
L VQ P F ++P +++S+ AG+ + TC G P P VTWLK+ + +
Sbjct: 3118 --LTVQVPPTF-ENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVV 3174
Query: 380 NNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTVLWA 420
+ L +S + P Y CVAEN+ ++ + VL A
Sbjct: 3175 SRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVA 3215
Score = 114 bits (285), Expect = 4e-25
Identities = 105/380 (27%), Positives = 150/380 (39%), Gaps = 34/380 (8%)
Query: 53 AVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLL-ANGSLMIRHFRLEPGGSPSD 111
A+ + L C V P +TW K+ L LL +L + RL SD
Sbjct: 2949 AILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARL------SD 3002
Query: 112 EGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQ----ATVGEEGGVARFQCQIHGLPK 167
G Y C A N G + ++ F P+ A + G A C+ LP+
Sbjct: 3003 SGMYTCEALNAAGRD-QKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPE 3061
Query: 168 PLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLTV 227
P +TW K+ P+ L L+I + D G++ C SN+A + LTV
Sbjct: 3062 PTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAV-RTFTLTV 3120
Query: 228 SGSGSGAYKEPAILVGPENLTLTVHQTA----VLECVATGNPRPIVSWSRLDGRPI---G 280
+ P P+ T TV Q A VL C +G P P V+W + D P+
Sbjct: 3121 --------QVPPTFENPK--TETVSQVAGSPLVLTCDVSGVPAPTVTWLK-DRMPVESSA 3169
Query: 281 VEGIQVLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSIS 340
V G+ G G L +S + +G Y C A R+ ++V +
Sbjct: 3170 VHGVVSRG-GRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHH 3228
Query: 341 RPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGP--GGHVRLKNNNSTLTISGIGPEDEAIY 398
G C+A G+PPP V WLK+G LG G H+R + +L + G+ D Y
Sbjct: 3229 VLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAY 3288
Query: 399 QCVAENSAGSSQASARLTVL 418
CVA N AG + VL
Sbjct: 3289 TCVAHNPAGEDARLHTVNVL 3308
Score = 113 bits (282), Expect = 8e-25
Identities = 101/377 (26%), Positives = 145/377 (38%), Gaps = 26/377 (6%)
Query: 57 QPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRLEPGGSPSDEGDYE 116
QP+++ C V P R+ R+ L E H N S I S ++EG YE
Sbjct: 442 QPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILR------ASKAEEGTYE 495
Query: 117 CVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGLPKPLITWEKNR 176
C A +R G ++ + P TV G A C++ G +TW ++
Sbjct: 496 CTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSP-GETAVLSCRVLGEAPYNLTWVRDW 554
Query: 177 VPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLTVSGSGSGAYK 236
+ R L L+I+G+ DGG + CVASN + T + +
Sbjct: 555 RVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGV--------TRASVWLLVRE 606
Query: 237 EPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEGIQVLGTGNLIISD 296
P + + + + + C A+G P P +SWSR I V G LII
Sbjct: 607 APQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQG 666
Query: 297 VTVQHSGVYVC-AANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQG 355
V + +G Y C A N GT L P + G A+ C+A G
Sbjct: 667 VAPEDAGNYSCQATNEVGTDQETVT---LYYTDPPSVSAVNAVVLVAVGEEAVLVCEASG 723
Query: 356 EPPPHVTWLKNG--QVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASA 413
PPP V W + G +L P G +++ L I D Y C A N G + A
Sbjct: 724 VPPPRVIWYRGGLEMILAPEG-----SSSGKLRIPAAQERDAGTYTCRAVNELGDASAEI 778
Query: 414 RLTVLWAEGLPGPPRNV 430
+L V A L PR+V
Sbjct: 779 QLAVGHAPQLTELPRDV 795
Score = 113 bits (282), Expect = 8e-25
Identities = 114/408 (27%), Positives = 164/408 (40%), Gaps = 43/408 (10%)
Query: 54 VPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHS--TLLANGSLMIRHFRLEPGGSPSD 111
V G+ L C GTP ++TWRK P +L GSL + SP+D
Sbjct: 1219 VAGENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASV------SPAD 1272
Query: 112 EGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQATV-GEEGGVARFQCQIHGLPKPLI 170
GDYEC A N G R + S +A V G G +C +G P P I
Sbjct: 1273 SGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEI 1332
Query: 171 TWEKNR----VPIDTDNERYTL----------LPKGV-LQITGLRAEDGGIFHCVASNIA 215
W K+ VP+ + L L +G L ++ D G++ C A N A
Sbjct: 1333 VWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQA 1392
Query: 216 SI--RISHGARLTV-SGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWS 272
R H LT S G+GA +E L G + L+C +G P P V W+
Sbjct: 1393 GTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGAD---------VELQCWTSGVPTPQVEWT 1443
Query: 273 RLDGRPI--GVEGIQVLGTGNLI-ISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAP 329
+ D +P+ G +QV G ++ I+ V G Y C A P + R Q R+
Sbjct: 1444 K-DRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPT 1502
Query: 330 AEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISG 389
++ C+A+G P P++TW K+G +L V L +
Sbjct: 1503 IWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGR 1562
Query: 390 IGPEDEAIYQCVAENSAGSSQASARLTVL---WAEGLPGPPRNVRAVS 434
D +Y C A N+ G+++ + RL V EG G P V+AV+
Sbjct: 1563 AQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVA 1610
Score = 112 bits (279), Expect = 2e-24
Identities = 107/377 (28%), Positives = 144/377 (38%), Gaps = 40/377 (10%)
Query: 56 GQPIVLDCRVEGTPPVRITWRKNGVEL---PESTHSTLLANGSLMIRHFRLEPGGSPSDE 112
G+ VL C G PP R+ W + G+E+ PE + S G L I P D
Sbjct: 712 GEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSS-----GKLRI------PAAQERDA 760
Query: 113 GDYECVAQNRFGLVVSRKARIQAAT--MSDFHVHPQATVGEEGGVARFQCQIHGLPKPLI 170
G Y C A N G A IQ A P+ E G A C+ G P P +
Sbjct: 761 GTYTCRAVNELG---DASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTV 817
Query: 171 TWEK-NRVPIDTD-----NERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGAR 224
TW + + P+ R GVL + ED + C A N+ ++ AR
Sbjct: 818 TWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFG-KVQAEAR 876
Query: 225 LTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVA-TGNPRPIVSWSRLDGRPIGVEG 283
L V+G + P I + + Q L C+ G P P W + DGRP+
Sbjct: 877 LIVTG-----HAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLK-DGRPLPPGS 930
Query: 284 IQ-VLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRP 342
+ G+L + +H+G Y C A R + LVVQ P HP +
Sbjct: 931 RHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVE--LVVQVPPRI--HPTATHHI 986
Query: 343 A--GTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQC 400
G A C A G P P +TW K L G + TL I+ +D Y C
Sbjct: 987 TNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVC 1046
Query: 401 VAENSAGSSQASARLTV 417
A N+ G S RL+V
Sbjct: 1047 TATNTVGFSSQEMRLSV 1063
Score = 112 bits (279), Expect = 2e-24
Identities = 142/553 (25%), Positives = 212/553 (38%), Gaps = 88/553 (15%)
Query: 38 HSAELAFAVEPSDDVAVPGQPIV-LDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSL 96
H+ + + +VAV +V L C G P ITW K+G LP ST G
Sbjct: 1498 HAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGG-- 1555
Query: 97 MIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGG-- 154
R +L S SD G Y C A N G + AT D +V P T+ GG
Sbjct: 1556 --RQLQLGRAQS-SDAGVYTCKASNAVGAA-------EKATRLDVYVPP--TIEGAGGRP 1603
Query: 155 ---------VARFQCQIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGG 205
+C G P P ++W +P+ NE VL++ G
Sbjct: 1604 YVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSG 1663
Query: 206 IFHCVASNIASIRI-SHGARLTVSGSGSGAYKEPAILV--GPENLTLTVHQTAVLECVAT 262
++ CVAS+ A + + + V P +LV G +T V Q L C A+
Sbjct: 1664 LYSCVASSPAGEAVLQYSVEVQVP---------PQLLVAEGLGQVTTIVGQPLELPCQAS 1714
Query: 263 GNPRPIVSWSRLDGRPIG-VEGIQVLGTGNLI-ISDVTVQHSGVYVC-AANRPGT---RV 316
G+P P + W + +GRP + G+QV G + I V + HSG++ C A N GT V
Sbjct: 1715 GSPVPTIQWLQ-NGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEV 1773
Query: 317 RRTAQGRL---VVQAPAEFV----QHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQV 369
+ G V++ P +H S A +PP W G +
Sbjct: 1774 EVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSL 1833
Query: 370 LG-PGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAEGLPGPPR 428
G P G + L I + DE IY C A N AG S+ L VL + P
Sbjct: 1834 WGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPV 1893
Query: 429 NVRAVSVSSTEVR----------VSW---SEPLAN----TKEIIGYVLHIRKAADPPELE 471
N + +S + VSW +P+++ T + G VL I +A
Sbjct: 1894 NKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQA------- 1946
Query: 472 YQEAVSKSTFQHLVSDLEPSTAYSFYIKAYTPRGAS---SASVPTLASTLGEAPAPPPLS 528
+ +++ + S++ ST + ++ P + S P L +T P L+
Sbjct: 1947 --QLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNT------PVRLT 1998
Query: 529 VRVLGSSSLQLLW 541
G+ S L+W
Sbjct: 1999 CNATGAPSPTLMW 2011
Score = 109 bits (272), Expect = 1e-23
Identities = 90/319 (28%), Positives = 132/319 (41%), Gaps = 17/319 (5%)
Query: 111 DEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGLPKPLI 170
DEG Y C A N G R+ ++ + P E +C G+P P +
Sbjct: 1859 DEGIYTCAATNLAG-ESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDV 1917
Query: 171 TWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIA-SIRISHGARLTVSG 229
+W K P+ + + VL+I + D G + CVASN+A S + +G R+ V
Sbjct: 1918 SWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPP 1977
Query: 230 SGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPI---GVEGIQV 286
P L GP + V+ L C ATG P P + W + DG P+ G G+QV
Sbjct: 1978 R----ITLPPSLPGP----VLVNTPVRLTCNATGAPSPTLMWLK-DGNPVSPAGTPGLQV 2028
Query: 287 LGTGNLI-ISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGT 345
G ++ ++ SG Y C A R+ L V P + ++S A
Sbjct: 2029 FPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVV--LQVHMPPSILGEELNVSVVANE 2086
Query: 346 TAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENS 405
+ CQ+ PPP ++W K+G+ L P V L + + L + D Y C A N
Sbjct: 2087 SVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQ 2146
Query: 406 AGSSQASARLTVLWAEGLP 424
AG S+ L V A P
Sbjct: 2147 AGHSEKHYNLNVWVAPVFP 2165
Score = 108 bits (271), Expect = 2e-23
Identities = 100/366 (27%), Positives = 146/366 (39%), Gaps = 26/366 (7%)
Query: 56 GQPIVLDCRVEGTPPVRITWRKNGVELPESTHS-TLLANGSLMIRHFRLEPGGSPSDEGD 114
G L C+ G+P ITW K+G + + T+ +G L++++ + D G
Sbjct: 4052 GSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQ------DAGT 4105
Query: 115 YECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGLPKPLITWEK 174
Y C A+N G R+ + + F P G +C G P P I W
Sbjct: 4106 YTCTAENAVGRA-RRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTV 4164
Query: 175 NRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLTVSGSGSGA 234
N P+ LQ + ED G + C A N R+ ++
Sbjct: 4165 NDRPVTEGVSEQD--GGSTLQRAAVSREDSGTYVCWAEN----RVGRTQAVSFVH----- 4213
Query: 235 YKEPAILVGP--ENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPI-GVEGIQVLGTGN 291
KE +L G L V + L+CV G+P P + W + DG P+ G L G+
Sbjct: 4214 VKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIK-DGLPLRGSHLRHQLQNGS 4272
Query: 292 LIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTC 351
L I +G Y C A ++ LV+Q+ F PQ ++ +G C
Sbjct: 4273 LTIHRTERDDAGRYQCLAENEMGVAKKVVI--LVLQSAPVFQVEPQDMTVRSGDDVALRC 4330
Query: 352 QAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQA 411
QA GEP P + WL+ GQ L +R + S L + + D Y CVA N GS+ A
Sbjct: 4331 QATGEPTPTIEWLQAGQPLRASRRLRTLPDGS-LWLENVETGDAGTYDCVAHNLLGSATA 4389
Query: 412 SARLTV 417
A L V
Sbjct: 4390 RAFLVV 4395
Score = 107 bits (266), Expect = 6e-23
Identities = 113/420 (26%), Positives = 168/420 (40%), Gaps = 43/420 (10%)
Query: 24 LLLLLLPAPSEGLGHSAELAFAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELP 83
L +LL P G SA+ V ++ PI L C P ITW K+G
Sbjct: 2531 LSVLLAPTILGGAEDSADEEVTVTVNN-------PISLICEALAFPSPNITWMKDGAPFE 2583
Query: 84 ESTHSTLL-ANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFH 142
S + LL L I + + E D G Y CV N G V S
Sbjct: 2584 ASRNIQLLPGTHGLQILNAQKE------DAGQYTCVVTNELGEAVKNYHVEVLIPPSISK 2637
Query: 143 VHPQATVGEE------GGVARFQCQIHGLPKPLITWEKNRVPIDTDNERYTLLPKG-VLQ 195
P VG + +C+ +P P I W K+ P+ T + R +L +G +LQ
Sbjct: 2638 DDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPV-TPSSRLQVLGEGRLLQ 2696
Query: 196 ITGLRAEDGGIFHCVASNIA-------SIRISHGARLTVSGSGSGAYK-----EPAILVG 243
I + D G + CVA+N+A ++ I G S A++ E A
Sbjct: 2697 IQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGV 2756
Query: 244 PENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEGIQVLGTGNLI-ISDVTVQHS 302
E + + A L C P P ++W R D + + VL G ++ I V +++
Sbjct: 2757 TEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENA 2816
Query: 303 GVYVC-AANRPGTRVRRTAQGRLVVQAPAEFV----QHPQSISRPAGTTAMFTCQAQGEP 357
G Y C A+N G L+V P + + + ++ A +T C A G P
Sbjct: 2817 GRYSCKASNEVG---EDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNP 2873
Query: 358 PPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTV 417
P ++WL+NG P +++ + L +S D A Y CVAEN AGS++ L V
Sbjct: 2874 VPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRV 2933
Score = 105 bits (262), Expect = 2e-22
Identities = 111/390 (28%), Positives = 160/390 (41%), Gaps = 54/390 (13%)
Query: 56 GQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRLEPGGSPSDEGDY 115
G+ + L+C EG P +++W K+GV L GS+ R SD G Y
Sbjct: 1134 GEALDLNCVAEGNPEPQLSWSKDGVVLQGRG-----PQGSVHFAAIR------TSDAGRY 1182
Query: 116 ECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVG----EEGGVARFQCQIHGLPKPLIT 171
C A N G+ ++ + H T G G A C G PKP +T
Sbjct: 1183 RCEASNSAGV---DAWEVELRVLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVT 1239
Query: 172 WEK--NRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLTVSG 229
W K + P+ +L +G L + + D G + C A+N S A+L V
Sbjct: 1240 WRKGPSSEPLH-GQPGVAVLEEGSLFLASVSPADSGDYECQATNEVG-STSRRAKLVV-- 1295
Query: 230 SGSGAYKEPAILVG--PENLTLTVHQTAVLECVATGNPRPIVSW---SRLDGRPIG---- 280
Y P+I N++ Q+ LEC A G P P + W ++L G P+G
Sbjct: 1296 -----YVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGY 1350
Query: 281 --------VEGIQVLGTG-NLIISDVTVQHSGVYVC-AANRPGTRVRRTAQGRLVVQAPA 330
V G ++L G +L + SG+Y C A N+ GT R L+V P
Sbjct: 1351 GWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQR---DFHLLVLTPP 1407
Query: 331 EFV--QHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGG-HVRLKNNNSTLTI 387
+ Q + AG C G P P V W K+ Q + PGG H++++ + L I
Sbjct: 1408 SVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRI 1467
Query: 388 SGIGPEDEAIYQCVAENSAGSSQASARLTV 417
+G DE YQCVA + AG +L V
Sbjct: 1468 TGSHVGDEGRYQCVAFSPAGQQARDFQLRV 1497
Score = 104 bits (260), Expect = 3e-22
Identities = 106/392 (27%), Positives = 151/392 (38%), Gaps = 42/392 (10%)
Query: 49 SDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRLEPGGS 108
+D V V G + L C G P ++W K+G E S L G + +LE G+
Sbjct: 3414 NDVVVVRGSLVELPCEARGVPLPLVSWMKDG----EPLLSQSLEQGPSL----QLEAVGA 3465
Query: 109 PSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGE----EGGVARFQCQIHG 164
D G Y CVA + G + Q M H+ E G C G
Sbjct: 3466 -GDSGTYSCVAVSEAG---EARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQG 3521
Query: 165 LPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGAR 224
P+P ITW K D + T L LR D G++ C+A + A I R
Sbjct: 3522 TPQPNITWHK-------DGQALTRLENNSRATRVLRVRDAGLYTCLAESPAG-AIEKSFR 3573
Query: 225 LTVSGSGSGAYKEPAILVGPENLTLTVHQT---AVLECVATGNPRPIVSWSRLDGRPIGV 281
+ V + P +VGP V VLEC P P ++W R DG +
Sbjct: 3574 VRV--------QAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHR-DGIVLQE 3624
Query: 282 EG-IQVLGTGNLI-ISDVTVQHSGVYVCAA-NRPGTRVRRTAQGRLVVQAPAEFVQHPQS 338
+ Q G + + ++ SG Y C A N G+ + R+ + P +
Sbjct: 3625 DAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGS---TSVAFRVEIHTVPTIRSGPPA 3681
Query: 339 ISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIY 398
++ TA+ CQA G P P V+W K+ L P +L I + +D Y
Sbjct: 3682 VNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHY 3741
Query: 399 QCVAENSAGSSQASARLTVLWAEGLPGPPRNV 430
C+A NSAGS + L VL + P N+
Sbjct: 3742 LCLASNSAGSDRQGRDLRVLEPPAIAPSPSNL 3773
Score = 103 bits (257), Expect = 6e-22
Identities = 96/391 (24%), Positives = 153/391 (39%), Gaps = 30/391 (7%)
Query: 41 ELAFAVEPSDDVAVPGQPIV-LDCRVEGTPPVRITWRKNGVELPESTHSTLLANG-SLMI 98
++A EP V+V + L+C G PP +TW ++G + L G SL +
Sbjct: 2257 QIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHV 2316
Query: 99 RHFRLEPGGSPSDEGDYECVAQNRFGLVVSR---KARIQAATMSDFHVHPQATVGEEGGV 155
+ G Y CVA+N G + + + D T +
Sbjct: 2317 ER------AQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPL 2370
Query: 156 ARFQCQIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIA 215
C+ G+P P I W + P+ + Y L +L++T + +D G++ C+ASN A
Sbjct: 2371 TLL-CEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEA 2429
Query: 216 S-IRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRL 274
R + + V S E I V QTA L C TG+P+P ++W +
Sbjct: 2430 GEARRNFSVEVLVPPSIENEDLEEVIKV-------LDGQTAHLMCNVTGHPQPKLTWFK- 2481
Query: 275 DGRPIGVEGIQVLGTGNLIIS--DVTVQHSGVYVC-AANRPGTRVRRTAQGRLVVQAPAE 331
DGRP+ + +++ + +G Y C AAN G + + V+ AP
Sbjct: 2482 DGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLS--VLLAPTI 2539
Query: 332 FVQHPQSISRPAGTTA----MFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTI 387
S T C+A P P++TW+K+G +++L L I
Sbjct: 2540 LGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQI 2599
Query: 388 SGIGPEDEAIYQCVAENSAGSSQASARLTVL 418
ED Y CV N G + + + VL
Sbjct: 2600 LNAQKEDAGQYTCVVTNELGEAVKNYHVEVL 2630
Score = 100 bits (249), Expect = 5e-21
Identities = 104/403 (25%), Positives = 164/403 (40%), Gaps = 39/403 (9%)
Query: 48 PSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRLEPGG 107
P + + + L+C G PP ++W K + T+ +G ++ R+E
Sbjct: 1892 PVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVL----RIEQA- 1946
Query: 108 SPSDEGDYECVAQN-------RFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQC 160
SD G Y CVA N R+GL V+ RI V V R C
Sbjct: 1947 QLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPV-------RLTC 1999
Query: 161 QIHGLPKPLITWEKNRVPID-TDNERYTLLPKG-VLQITGLRAEDGGIFHCVASNIASIR 218
G P P + W K+ P+ + P G VL + RA D G + CVA +
Sbjct: 2000 NATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVG-E 2058
Query: 219 ISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRP 278
L V + P+IL N+++ +++ LEC + P P++SW + DGRP
Sbjct: 2059 DRQDVVLQV-------HMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWK-DGRP 2110
Query: 279 IGVE-GIQVLGTGNLIISD-VTVQHSGVYVCAA-NRPGTRVRRTAQGRLVVQAPAEFVQH 335
+ G+ + L+ D V +G Y C A N+ G + V AP ++
Sbjct: 2111 LEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWV--APVFPLRE 2168
Query: 336 PQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGP--- 392
+++ G +C+ +G P P ++W K+GQ L PG L++ ++ + +G
Sbjct: 2169 SHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPL-PGEGAGLQHVSAVGRLLYLGQAQL 2227
Query: 393 EDEAIYQCVAENSAGSSQASARLTVLWAEGLPGPPRNVRAVSV 435
E Y C N G+S +L V + GP VSV
Sbjct: 2228 AQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSV 2270
Score = 92.4 bits (228), Expect = 1e-18
Identities = 108/411 (26%), Positives = 154/411 (37%), Gaps = 52/411 (12%)
Query: 54 VPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGS-LMIRHFRLEPGGSPSDE 112
+ GQP+ L C+ G+P I W +NG E + + G+ L I H L+ G
Sbjct: 1702 IVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGL---- 1757
Query: 113 GDYECVAQNRFGLV-----VSRKARIQAATM--------------SDFHVHPQATVGEEG 153
+ C A N G VS + S F V
Sbjct: 1758 --FACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGW 1815
Query: 154 GVARFQCQIHGLPKPLITW-EKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVAS 212
G + G P W E +P+ Y+L P LQI + D GI+ C A+
Sbjct: 1816 GAHPKPPLVEGWCSPGSLWGEPTGIPV-----AYSLPPP--LQIEKVDLRDEGIYTCAAT 1868
Query: 213 NIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWS 272
N+A A + P I GP N + + + LEC+A+G P P VSW
Sbjct: 1869 NLAGESKREVALKVLV--------PPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWF 1920
Query: 273 RLDGRPIGVEGIQVLGTGNLI-ISDVTVQHSGVYVC-AANRPGTRVRRTAQGRLVVQAPA 330
+ G+ V G ++ I + +G Y C A+N G+ R L V P
Sbjct: 1921 KGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYG---LRVNVPP 1977
Query: 331 EFVQHPQSISRPA--GTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLK--NNNSTLT 386
+ P S+ P T TC A G P P + WLK+G + P G L+ LT
Sbjct: 1978 R-ITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLT 2036
Query: 387 ISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAEGLPGPPRNVRAVSVSS 437
++ D Y CVA ++ G + L V + G NV V+ S
Sbjct: 2037 LASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANES 2087
Score = 81.6 bits (200), Expect = 3e-15
Identities = 73/274 (26%), Positives = 111/274 (40%), Gaps = 30/274 (10%)
Query: 44 FAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRL 103
F P D G + L C G+P RI W N + E GS + R
Sbjct: 4131 FTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQ--DGGSTLQR---- 4184
Query: 104 EPGGSPSDEGDYECVAQNRFG------LVVSRKARIQAATMSDFHVHPQATVGEEGGVAR 157
S D G Y C A+NR G V ++A + + V P GG +
Sbjct: 4185 -AAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEP------VGGSIQ 4237
Query: 158 FQCQIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASI 217
C + G P P I W K+ +P+ + R+ L G L I +D G + C+A N +
Sbjct: 4238 LDCVVRGDPVPDIHWIKDGLPLRGSHLRHQ-LQNGSLTIHRTERDDAGRYQCLAEN--EM 4294
Query: 218 RISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGR 277
++ + V S P V P+++T+ L C ATG P P + W + G+
Sbjct: 4295 GVAKKVVILVLQSA------PVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQA-GQ 4347
Query: 278 PI-GVEGIQVLGTGNLIISDVTVQHSGVYVCAAN 310
P+ ++ L G+L + +V +G Y C A+
Sbjct: 4348 PLRASRRLRTLPDGSLWLENVETGDAGTYDCVAH 4381
Score = 66.2 bits (160), Expect = 1e-10
Identities = 89/393 (22%), Positives = 163/393 (41%), Gaps = 40/393 (10%)
Query: 225 LTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEG- 283
++ SG GA P + + P + +HQ ++ C + + P R +G E
Sbjct: 418 VSYSGVAPGA---PLVSMAPR-IHGYLHQPLLVSC-SVHSALPFRLQLRRGEARLGEERH 472
Query: 284 IQVLGTGNLIISDVTVQHSGVYVCAA-NRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRP 342
Q G + I + G Y C A +R GT A+ ++VV P + +++
Sbjct: 473 FQESGNSSWEILRASKAEEGTYECTAVSRAGTG---RAKAQIVVTDPPPQLVPAPNVTVS 529
Query: 343 AGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVA 402
G TA+ +C+ GE P ++TW+++ +VL + + +L ISGI P D YQCVA
Sbjct: 530 PGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVA 589
Query: 403 ENSAGSSQASARLTVLWAEGLPGPPRNVRAVSVSSTEVRVSWSEPLANTKEIIGY-VLHI 461
N+ G ++AS L V R VS+ ++ S + + GY HI
Sbjct: 590 SNANGVTRASVWLLV----------REAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHI 639
Query: 462 RKAADPPELEYQEAV---SKSTFQHLVSDLEPSTAYSFYIKAYTPRGASSASVPTLASTL 518
+ + L+ + ++ T ++ + P A ++ +A G +V +
Sbjct: 640 SWSRESQALQEDSRIHVDAQGTL--IIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDP 697
Query: 519 GEAPAPPPLSVRVLGSSSL---QLLWEPWPRLAQHEGGFKLFYRPASKTSFTGPILLPGT 575
A + + +G ++ + P PR+ + GG ++ P +S G + +P
Sbjct: 698 PSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSS--GKLRIPA- 754
Query: 576 VSSYNLSQLDPTAVYEVKLLAYNQHGDGNATVR 608
+Q Y + A N+ GD +A ++
Sbjct: 755 ------AQERDAGTYTCR--AVNELGDASAEIQ 779
Score = 48.5 bits (114), Expect = 2e-05
Identities = 30/86 (34%), Positives = 39/86 (45%), Gaps = 6/86 (6%)
Query: 44 FAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRL 103
F VEP D G + L C+ G P I W + G L S L +GSL + + +
Sbjct: 4311 FQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLEN--V 4368
Query: 104 EPGGSPSDEGDYECVAQNRFGLVVSR 129
E G D G Y+CVA N G +R
Sbjct: 4369 ETG----DAGTYDCVAHNLLGSATAR 4390
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 172 bits (436), Expect = 1e-42
Identities = 121/384 (31%), Positives = 177/384 (46%), Gaps = 22/384 (5%)
Query: 55 PGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRLEPGGSPSDEGD 114
PGQ +VL+C VE P +ITW ++G+ L E H+ G R +L+ S +D GD
Sbjct: 2314 PGQ-LVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERG----RFLQLQ-ALSTADSGD 2367
Query: 115 YECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGLPKPLITWEK 174
Y C A+N G S R++ T+ P A A CQ G+P PL++W K
Sbjct: 2368 YSCTARNAAGST-SVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRK 2426
Query: 175 NRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLTVSGSGSGA 234
+RVP+D + R+ +LP+G L+I + A+D G + C+ASN A G
Sbjct: 2427 DRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASN--------SAGSDRQGRDLRV 2478
Query: 235 YKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVE----GIQVLGTG 290
+ PAI P NLTLT H A+L C A+G+P+P+V W + DG+ + ++L +
Sbjct: 2479 LEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWK-DGQKLDFRLQQGAYRLLPSN 2537
Query: 291 NLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFT 350
L+++ Q S + C + R Q + V P + + T
Sbjct: 2538 ALLLTAPGPQDSAQFECVVSNEVGEAHRLYQ--VTVHVPPTIADDQTDFTVTMMAPVVLT 2595
Query: 351 CQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQ 410
C + G P P V+W K G LG G + + L I P Y C A NSAG +
Sbjct: 2596 CHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAH 2655
Query: 411 ASARLTVLWAEGLPGPPRNVRAVS 434
LTV + + P VRAV+
Sbjct: 2656 KHVFLTVQASPVVKPLPSVVRAVA 2679
Score = 157 bits (398), Expect = 3e-38
Identities = 124/385 (32%), Positives = 179/385 (46%), Gaps = 46/385 (11%)
Query: 47 EPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRLEPG 106
+P++ PG P+ L C +GTP ITW K+G L T L N S R R+
Sbjct: 2219 QPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQAL------TRLENNSRATRVLRVR-- 2270
Query: 107 GSPSDEGDYECVAQNRFGLV-VSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGL 165
D G Y C+A++ G + S + R+QA P+ VG G +C +
Sbjct: 2271 ----DAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAE 2326
Query: 166 PKPLITWEKNRVPIDTDNERYTLLPK--GVLQITGLRAEDGGIFHCVASNIASIRISHGA 223
P P ITW ++ + + D +T P+ LQ+ L D G + C A N A
Sbjct: 2327 PAPKITWHRDGIVLQED--AHTQFPERGRFLQLQALSTADSGDYSCTARNAA-------- 2376
Query: 224 RLTVSGSGSGAYK-----EPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRP 278
GS S A++ P I GP + ++V+QTA+L C A G P P+VSW R D P
Sbjct: 2377 -----GSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSW-RKDRVP 2430
Query: 279 IGVEG--IQVLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGR-LVVQAPAEFVQH 335
+ ++L G+L I V Q +G Y+C A+ R QGR L V P
Sbjct: 2431 LDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDR---QGRDLRVLEPPAIAPS 2487
Query: 336 PQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLG---PGGHVRLKNNNSTLTISGIGP 392
P +++ A T A+ C+A G P P V W K+GQ L G RL +N+ L ++ GP
Sbjct: 2488 PSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNA-LLLTAPGP 2546
Query: 393 EDEAIYQCVAENSAGSSQASARLTV 417
+D A ++CV N G + ++TV
Sbjct: 2547 QDSAQFECVVSNEVGEAHRLYQVTV 2571
Score = 152 bits (383), Expect = 2e-36
Identities = 114/398 (28%), Positives = 180/398 (45%), Gaps = 26/398 (6%)
Query: 48 PSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRLEPGG 107
PS AV + ++L C G P ITW+K G+ + + +L G L I H
Sbjct: 2672 PSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAH------A 2725
Query: 108 SPSDEGDYECVAQNRFGLVVSR-KARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGLP 166
SP D G+Y C+A+N G + + + +Q + + + +T EG A C+ G P
Sbjct: 2726 SPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTT--EGSHAFLPCKARGSP 2783
Query: 167 KPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLT 226
+P ITW+K+ P+ ++T+ P G L + L +D G + C A N R LT
Sbjct: 2784 EPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVG-RARRRVHLT 2842
Query: 227 VSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEGI-Q 285
+ P P + +L + L C A G+P P + W+ ++ RP+ EG+ +
Sbjct: 2843 I-------LVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWT-VNDRPV-TEGVSE 2893
Query: 286 VLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRL--VVQAPAEFVQHPQSISRPA 343
G L + V+ + SG YVC A RV RT V +AP + + P
Sbjct: 2894 QDGGSTLQRAAVSREDSGTYVCWAE---NRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPV 2950
Query: 344 GTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAE 403
G + C +G+P P + W+K+G L G H+R + N +LTI +D YQC+AE
Sbjct: 2951 GGSIQLDCVVRGDPVPDIHWIKDGLPL-RGSHLRHQLQNGSLTIRRTERDDAGRYQCLAE 3009
Query: 404 NSAGSSQASARLTVLWAEGLPGPPRNVRAVSVSSTEVR 441
N G ++ L + A P+++ S +R
Sbjct: 3010 NEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALR 3047
Score = 136 bits (342), Expect = 9e-32
Identities = 120/397 (30%), Positives = 169/397 (42%), Gaps = 40/397 (10%)
Query: 39 SAELAFAVE-----------PSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVEL-PEST 86
S +AF VE P+ +V+V Q +L C+ +G P ++WRK+ V L P S
Sbjct: 2378 STSVAFRVEIHTVPTIRSGPPAVNVSV-NQTALLPCQADGVPAPLVSWRKDRVPLDPRSP 2436
Query: 87 HSTLLANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKAR-IQAATMSDFHVHP 145
+L GSL I+ + D G Y C+A N G R+ R ++ P
Sbjct: 2437 RFEILPEGSLRIQPVLAQ------DAGHYLCLASNSAGS--DRQGRDLRVLEPPAIAPSP 2488
Query: 146 QATVGEEGGVARFQCQIHGLPKPLITWEKNRVPIDTDNER--YTLLPKGVLQITGLRAED 203
A C+ G PKPL+ W K+ +D ++ Y LLP L +T +D
Sbjct: 2489 SNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQD 2548
Query: 204 GGIFHCVASNIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATG 263
F CV SN + RL + P I + T+T+ VL C +TG
Sbjct: 2549 SAQFECVVSN----EVGEAHRLYQVT----VHVPPTIADDQTDFTVTMMAPVVLTCHSTG 2600
Query: 264 NPRPIVSWSRLDGRPIGVEG--IQVLGTGNLIISDVTVQHSGVYVCAA-NRPGTRVRRTA 320
P P VSWS+ G +G G +V +G L I H+G Y C+A N G +
Sbjct: 2601 IPAPTVSWSKA-GAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVF 2659
Query: 321 QGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKN 380
L VQA P + A + C+A G P P +TW K G + G ++
Sbjct: 2660 ---LTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLP 2716
Query: 381 NNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTV 417
L I+ PED Y C+A+NSAGS+ RL V
Sbjct: 2717 GGQ-LRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVV 2752
Score = 130 bits (328), Expect = 4e-30
Identities = 108/394 (27%), Positives = 180/394 (45%), Gaps = 41/394 (10%)
Query: 52 VAVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANG-SLMIRHFRLEPGGSPS 110
V+ PG+ + + C V G+PP+ ++W K+G+ LP S + L +G +L I +L +
Sbjct: 2042 VSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQL------A 2095
Query: 111 DEGDYECVAQNRFGLVVSR-KARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGLPKPL 169
D G + CVA + G+ ++Q + + V G + C+ G+P PL
Sbjct: 2096 DAGIFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPL 2155
Query: 170 ITWEKNRVPIDTDNERYTLLPKGV-LQITGLRAEDGGIFHCVASNIASIRISHGARLTVS 228
++W K+ P+ + + L +G LQ+ + A D G + CVA + A H +LTV
Sbjct: 2156 VSWMKDGEPLLSQS-----LEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRH-FQLTVM 2209
Query: 229 GSGSGAYKEPAILVG---PENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEGIQ 285
EP + P L+LT L C A G P+P ++W + DG + +
Sbjct: 2210 --------EPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHK-DG-----QALT 2255
Query: 286 VLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFV--QHPQSISRPA 343
L + + V+ +G+Y C A P + ++ + R VQAP V + P+ + A
Sbjct: 2256 RLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVR--VQAPPNIVGPRGPRFVVGLA 2313
Query: 344 GTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAE 403
+ C + EP P +TW ++G VL H + L + + D Y C A
Sbjct: 2314 PGQLVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTAR 2373
Query: 404 NSAGSSQASARLTVLWAEGL-PGPPRNVRAVSVS 436
N+AGS+ + R+ + + GPP AV+VS
Sbjct: 2374 NAAGSTSVAFRVEIHTVPTIRSGPP----AVNVS 2403
Score = 122 bits (307), Expect = 1e-27
Identities = 131/530 (24%), Positives = 209/530 (39%), Gaps = 75/530 (14%)
Query: 59 IVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRLEPGGSPSDEGDYECV 118
+ L+C PP I W K+G + S+ +L G L+ +++P SD G Y CV
Sbjct: 1375 LTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLL----QIQPT-QVSDSGRYLCV 1429
Query: 119 AQN-------RFGLVVSRKARIQAATMSDFHVHPQATVGEE---GGVARFQ--------- 159
A N F +++ Q + DF + EE GGV ++
Sbjct: 1430 ATNVAGEDDQDFNVLIQVPPMFQK--VGDFSAAFEILSREEEARGGVTEYREIVENNPAY 1487
Query: 160 --CQIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASI 217
C + +P P +TW + P+ +E L VLQI +RAE+ G + C ASN
Sbjct: 1488 LYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGE 1547
Query: 218 RISHGARLTVSGSGSGAYKEPAILVGP-----ENLTLTVHQTAVLECVATGNPRPIVSWS 272
H L ++ P +++G E +T+ T L+C A GNP P +SW
Sbjct: 1548 DWLHYELLVLT---------PPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWL 1598
Query: 273 RLDGRPIGVEG-IQVLGTGNLI-ISDVTVQHSGVYVCAA-NRPGTRVRRTAQGRLVVQAP 329
+ +G P +QVL G ++ +S V + Y+C A N+ G+ + L VQ P
Sbjct: 1599 Q-NGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFT---LRVQVP 1654
Query: 330 AEFVQHP-QSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTIS 388
+ ++ ++ C P P VTW K+ Q L G V L TL +
Sbjct: 1655 PRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLG 1714
Query: 389 GIGPEDEAIYQCVAENSAGSSQASARLTVLWAEGLPGPPRNV----------RAVSVSST 438
D +Y C A N+AG Q +L+VL PR +AV T
Sbjct: 1715 RARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCET 1774
Query: 439 ----EVRVSW---SEPLANTKEIIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPS 491
E V+W +PL ++ + E++ + K + VS++
Sbjct: 1775 DALPEPTVTWYKDGQPL-----VLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGE 1829
Query: 492 TAYSFYIKAYTPRGASSASVPTLASTLGEAPAPPPLSVRVLGSSSLQLLW 541
+F + P + T++ G +P L+ V G + + W
Sbjct: 1830 AVRTFTLTVQVPPTFENPKTETVSQVAG---SPLVLTCDVSGVPAPTVTW 1876
Score = 121 bits (303), Expect = 3e-27
Identities = 110/421 (26%), Positives = 173/421 (41%), Gaps = 58/421 (13%)
Query: 25 LLLLLPAPSEGLGHSAELAFAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVE-LP 83
LL+L P G G + E+ + + G + L C G P ++ W K+ LP
Sbjct: 119 LLVLTPPSVLGAGAAQEV---------LGLAGADVELQCWTSGVPTPQVEWTKDRQPVLP 169
Query: 84 ESTHSTLLANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHV 143
H + +G ++ R+ G DEG Y+CVA + G Q A V
Sbjct: 170 GGPHLQVQEDGQVL----RIT-GSHVGDEGRYQCVAFSPAG---------QQARDFQLRV 215
Query: 144 HPQATV---GEEGGVARFQ-------CQIHGLPKPLITWEKNRVPIDTDNERYTLLPKGV 193
H T+ E G VA + C+ G+P P ITW K+ + T +
Sbjct: 216 HAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQ 275
Query: 194 LQITGLRAEDGGIFHCVASNIA-----SIRISHGARLTVSGSGSGAYKEPAILVGPENLT 248
LQ+ ++ D G++ C ASN + R+ T+ G+G Y A+ P
Sbjct: 276 LQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRP---- 331
Query: 249 LTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEGIQVLGTGNLII--SDVTVQHSGVYV 306
LECVA G+P P +SW +G P+ L T ++ SG+Y
Sbjct: 332 ------VALECVARGHPSPTLSWHH-EGLPVAESNESRLETDGSVLRLESPGEASSGLYS 384
Query: 307 CAANRPGTRVRRTAQGRLVVQAPAEFV--QHPQSISRPAGTTAMFTCQAQGEPPPHVTWL 364
C A+ P Q + VQ P + + + ++ G CQA G P P + WL
Sbjct: 385 CVASSPAGEA--VLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWL 442
Query: 365 KNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTV--LWAEG 422
+NG+ V++ + +TL I + + ++ C A N AG++ A ++V WA G
Sbjct: 443 QNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPG 502
Query: 423 L 423
+
Sbjct: 503 V 503
Score = 117 bits (292), Expect = 6e-26
Identities = 109/417 (26%), Positives = 160/417 (38%), Gaps = 40/417 (9%)
Query: 56 GQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRLEPGGSPSDEGDY 115
G P L C G P +I+WRK+G LP L + S + R L + EG Y
Sbjct: 895 GHPTRLSCECRGVPFPKISWRKDGQPLPGEGAG--LQHVSAVGRLLYLGQA-QLAQEGTY 951
Query: 116 ECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEE---------GGVARFQCQIHGLP 166
C N G + HV PQ E GVA +C G P
Sbjct: 952 TCECSNVVG-------NSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKP 1004
Query: 167 KPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLT 226
P +TWE++ P+ + L + +A G + CVA N+A R L+
Sbjct: 1005 PPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAG-RAERKFELS 1063
Query: 227 VSGSGSGAYKEPAILVGP----ENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPI--G 280
V P L+G N+T +H L C A G P P + W R + P+ G
Sbjct: 1064 VL--------VPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGE-EPVSPG 1114
Query: 281 VEGIQVLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSIS 340
+ + G L ++ Q SG+Y C A+ RR ++V E + I
Sbjct: 1115 EDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIK 1174
Query: 341 RPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQC 400
G TA C G P P +TW K+G+ L G + + L + Y C
Sbjct: 1175 VLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSC 1234
Query: 401 VAENSAGSSQASARLTVLWAEGLPGPPRNVRAVSVSSTEVRVSWSEPLANTKEIIGY 457
+A N+ G +L+VL A + G A + EV V+ + P++ E + +
Sbjct: 1235 IAANAVGEKTKHFQLSVLLAPTILG-----GAEDSADEEVTVTVNNPISLICEALAF 1286
Score = 115 bits (288), Expect = 2e-25
Identities = 112/401 (27%), Positives = 170/401 (42%), Gaps = 28/401 (6%)
Query: 27 LLLPAPSEGLGHSAELAFAVEPSDDVAVPGQPIV-LDCRVEGTPPVRITWRKNGVELPES 85
LL+ P LG + EL ++V V V L C G P I+W +NG+ S
Sbjct: 1554 LLVLTPPVILGDTEELV------EEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPS 1607
Query: 86 THSTLLANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSR-KARIQAATMSDFHVH 144
+L +G ++ +D Y CVA+N+ G R+Q
Sbjct: 1608 PRLQVLEDGQVL-----QVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDL 1662
Query: 145 PQATVGEEGGVARFQCQIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDG 204
Q T V+ C +H P P +TW K+ + E + L LQ+ R D
Sbjct: 1663 EQVTAILNSSVS-LPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDS 1721
Query: 205 GIFHCVASNIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLT-VHQTAVLECVATG 263
G++ C A N A R +L+V A+++ GP++ L V AVL C
Sbjct: 1722 GMYTCEALNAAG-RDQKLVQLSVLVPP--AFRQAPR--GPQDAVLVRVGDKAVLSCETDA 1776
Query: 264 NPRPIVSWSRLDGRPIGV-EGIQVLGTGN-LIISDVTVQHSGVYVCAANRPGTRVRRTAQ 321
P P V+W + DG+P+ + + Q L G L I + V G+Y C + RT
Sbjct: 1777 LPEPTVTWYK-DGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFT 1835
Query: 322 GRLVVQAPAEFVQHP--QSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLK 379
L VQ P F ++P +++S+ AG+ + TC G P P VTWLK+ + +
Sbjct: 1836 --LTVQVPPTF-ENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVV 1892
Query: 380 NNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTVLWA 420
+ L +S + P Y CVAEN+ ++ + VL A
Sbjct: 1893 SRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVA 1933
Score = 114 bits (285), Expect = 4e-25
Identities = 97/374 (25%), Positives = 155/374 (41%), Gaps = 24/374 (6%)
Query: 54 VPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRLEPGGSPSDEG 113
V + + L+C+ PP ++W K+G L L A+ +L+ D G
Sbjct: 801 VANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALL-----QVDRADVWDAG 855
Query: 114 DYECVAQNRFGLVVSR-KARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGLPKPLITW 172
Y C A N+ G + A + TV EG R C+ G+P P I+W
Sbjct: 856 HYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTLTV-REGHPTRLSCECRGVPFPKISW 914
Query: 173 EKNRVPIDTDNE--RYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLTVSGS 230
K+ P+ + ++ +L + + G + C SN+ S +L V
Sbjct: 915 RKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVG-NSSQDLQLEVHVP 973
Query: 231 GS-GAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVE-GIQVLG 288
+EP P +++ A LEC ATG P P V+W R DG+P+G E G+Q+
Sbjct: 974 PQIAGPREP-----PTQVSVVQDGVATLECNATGKPPPTVTWER-DGQPVGAELGLQLQN 1027
Query: 289 TG-NLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFV---QHPQSISRPAG 344
G +L + H+G Y C A R R + L V P E + +I+
Sbjct: 1028 QGQSLHVERAQAAHTGRYSCVAENLAGRAERKFE--LSVLVPPELIGDLDPLTNITAALH 1085
Query: 345 TTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAEN 404
+ C+A G PPP + W + + + PG L L ++ +D +Y C+A N
Sbjct: 1086 SPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASN 1145
Query: 405 SAGSSQASARLTVL 418
AG ++ + + VL
Sbjct: 1146 EAGEARRNFSVEVL 1159
Score = 114 bits (285), Expect = 4e-25
Identities = 105/380 (27%), Positives = 150/380 (39%), Gaps = 34/380 (8%)
Query: 53 AVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLL-ANGSLMIRHFRLEPGGSPSD 111
A+ + L C V P +TW K+ L LL +L + RL SD
Sbjct: 1667 AILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARL------SD 1720
Query: 112 EGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQ----ATVGEEGGVARFQCQIHGLPK 167
G Y C A N G + ++ F P+ A + G A C+ LP+
Sbjct: 1721 SGMYTCEALNAAGRD-QKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPE 1779
Query: 168 PLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLTV 227
P +TW K+ P+ L L+I + D G++ C SN+A + LTV
Sbjct: 1780 PTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAV-RTFTLTV 1838
Query: 228 SGSGSGAYKEPAILVGPENLTLTVHQTA----VLECVATGNPRPIVSWSRLDGRPI---G 280
+ P P+ T TV Q A VL C +G P P V+W + D P+
Sbjct: 1839 --------QVPPTFENPK--TETVSQVAGSPLVLTCDVSGVPAPTVTWLK-DRMPVESSA 1887
Query: 281 VEGIQVLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSIS 340
V G+ G G L +S + +G Y C A R+ ++V +
Sbjct: 1888 VHGVVSRG-GRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHH 1946
Query: 341 RPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGP--GGHVRLKNNNSTLTISGIGPEDEAIY 398
G C+A G+PPP V WLK+G LG G H+R + +L + G+ D Y
Sbjct: 1947 VLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAY 2006
Query: 399 QCVAENSAGSSQASARLTVL 418
CVA N AG + VL
Sbjct: 2007 TCVAHNPAGEDARLHTVNVL 2026
Score = 113 bits (282), Expect = 8e-25
Identities = 108/396 (27%), Positives = 163/396 (41%), Gaps = 46/396 (11%)
Query: 58 PIVLDCRVEGTPPVRITWRKNGVEL-PESTHSTLLANGSLMIRHFRLEPGGSPSDEGDYE 116
P+ L C G P + W K+G + P T + G ++ SD G Y
Sbjct: 712 PVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVL----TLASARASDSGRYS 767
Query: 117 CVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVA-------RFQCQIHGLPKPL 169
CVA VS + + H+ P + +GEE V+ +CQ H +P P+
Sbjct: 768 CVA-------VSAVGEDRQDVVLQVHM-PPSILGEELNVSVVANESVALECQSHAMPPPV 819
Query: 170 ITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLTVSG 229
++W K+ P++ + K +LQ+ D G + C A N A H
Sbjct: 820 LSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKH-------- 871
Query: 230 SGSGAYKEPAILVGPENLTLTVHQ--TAVLECVATGNPRPIVSWSRLDGRPIGVEGI--- 284
+ P + E+ TLTV + L C G P P +SW R DG+P+ EG
Sbjct: 872 YNLNVWVAPVFPL-RESHTLTVREGHPTRLSCECRGVPFPKISW-RKDGQPLPGEGAGLQ 929
Query: 285 QVLGTGNLI-ISDVTVQHSGVYVCAANRPGTRVRRTAQG-RLVVQAPAEFV---QHPQSI 339
V G L+ + + G Y C + V ++Q +L V P + + P +
Sbjct: 930 HVSAVGRLLYLGQAQLAQEGTYTCECSNV---VGNSSQDLQLEVHVPPQIAGPREPPTQV 986
Query: 340 SRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQ 399
S A C A G+PPP VTW ++GQ +G ++L+N +L + Y
Sbjct: 987 SVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYS 1046
Query: 400 CVAENSAGSSQASARLTVLWAEGLPG---PPRNVRA 432
CVAEN AG ++ L+VL L G P N+ A
Sbjct: 1047 CVAENLAGRAERKFELSVLVPPELIGDLDPLTNITA 1082
Score = 112 bits (279), Expect = 2e-24
Identities = 142/553 (25%), Positives = 212/553 (38%), Gaps = 88/553 (15%)
Query: 38 HSAELAFAVEPSDDVAVPGQPIV-LDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSL 96
H+ + + +VAV +V L C G P ITW K+G LP ST G
Sbjct: 216 HAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGG-- 273
Query: 97 MIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGG-- 154
R +L S SD G Y C A N G + AT D +V P T+ GG
Sbjct: 274 --RQLQLGRAQS-SDAGVYTCKASNAVGAA-------EKATRLDVYVPP--TIEGAGGRP 321
Query: 155 ---------VARFQCQIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGG 205
+C G P P ++W +P+ NE VL++ G
Sbjct: 322 YVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSG 381
Query: 206 IFHCVASNIASIRI-SHGARLTVSGSGSGAYKEPAILV--GPENLTLTVHQTAVLECVAT 262
++ CVAS+ A + + + V P +LV G +T V Q L C A+
Sbjct: 382 LYSCVASSPAGEAVLQYSVEVQVP---------PQLLVAEGLGQVTTIVGQPLELPCQAS 432
Query: 263 GNPRPIVSWSRLDGRPIG-VEGIQVLGTGNLI-ISDVTVQHSGVYVC-AANRPGT---RV 316
G+P P + W + +GRP + G+QV G + I V + HSG++ C A N GT V
Sbjct: 433 GSPVPTIQWLQ-NGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEV 491
Query: 317 RRTAQGRL---VVQAPAEFV----QHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQV 369
+ G V++ P +H S A +PP W G +
Sbjct: 492 EVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSL 551
Query: 370 LG-PGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAEGLPGPPR 428
G P G + L I + DE IY C A N AG S+ L VL + P
Sbjct: 552 WGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPV 611
Query: 429 NVRAVSVSSTEVR----------VSW---SEPLAN----TKEIIGYVLHIRKAADPPELE 471
N + +S + VSW +P+++ T + G VL I +A
Sbjct: 612 NKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQA------- 664
Query: 472 YQEAVSKSTFQHLVSDLEPSTAYSFYIKAYTPRGAS---SASVPTLASTLGEAPAPPPLS 528
+ +++ + S++ ST + ++ P + S P L +T P L+
Sbjct: 665 --QLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNT------PVRLT 716
Query: 529 VRVLGSSSLQLLW 541
G+ S L+W
Sbjct: 717 CNATGAPSPTLMW 729
Score = 109 bits (272), Expect = 1e-23
Identities = 90/319 (28%), Positives = 132/319 (41%), Gaps = 17/319 (5%)
Query: 111 DEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGLPKPLI 170
DEG Y C A N G R+ ++ + P E +C G+P P +
Sbjct: 577 DEGIYTCAATNLAG-ESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDV 635
Query: 171 TWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIA-SIRISHGARLTVSG 229
+W K P+ + + VL+I + D G + CVASN+A S + +G R+ V
Sbjct: 636 SWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPP 695
Query: 230 SGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPI---GVEGIQV 286
P L GP + V+ L C ATG P P + W + DG P+ G G+QV
Sbjct: 696 R----ITLPPSLPGP----VLVNTPVRLTCNATGAPSPTLMWLK-DGNPVSPAGTPGLQV 746
Query: 287 LGTGNLI-ISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGT 345
G ++ ++ SG Y C A R+ L V P + ++S A
Sbjct: 747 FPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVV--LQVHMPPSILGEELNVSVVANE 804
Query: 346 TAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENS 405
+ CQ+ PPP ++W K+G+ L P V L + + L + D Y C A N
Sbjct: 805 SVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQ 864
Query: 406 AGSSQASARLTVLWAEGLP 424
AG S+ L V A P
Sbjct: 865 AGHSEKHYNLNVWVAPVFP 883
Score = 108 bits (271), Expect = 2e-23
Identities = 100/366 (27%), Positives = 146/366 (39%), Gaps = 26/366 (7%)
Query: 56 GQPIVLDCRVEGTPPVRITWRKNGVELPESTHS-TLLANGSLMIRHFRLEPGGSPSDEGD 114
G L C+ G+P ITW K+G + + T+ +G L++++ + D G
Sbjct: 2770 GSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQ------DAGT 2823
Query: 115 YECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGLPKPLITWEK 174
Y C A+N G R+ + + F P G +C G P P I W
Sbjct: 2824 YTCTAENAVGRA-RRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTV 2882
Query: 175 NRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLTVSGSGSGA 234
N P+ LQ + ED G + C A N R+ ++
Sbjct: 2883 NDRPVTEGVSEQD--GGSTLQRAAVSREDSGTYVCWAEN----RVGRTQAVSFVH----- 2931
Query: 235 YKEPAILVGP--ENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPI-GVEGIQVLGTGN 291
KE +L G L V + L+CV G+P P + W + DG P+ G L G+
Sbjct: 2932 VKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIK-DGLPLRGSHLRHQLQNGS 2990
Query: 292 LIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTC 351
L I +G Y C A ++ LV+Q+ F PQ ++ +G C
Sbjct: 2991 LTIRRTERDDAGRYQCLAENEMGVAKKVVI--LVLQSAPVFQVEPQDMTVRSGDDVALRC 3048
Query: 352 QAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQA 411
QA GEP P + WL+ GQ L +R + S L + + D Y CVA N GS+ A
Sbjct: 3049 QATGEPTPTIEWLQAGQPLRASRRLRTLPDGS-LWLENVETGDAGTYDCVAHNLLGSATA 3107
Query: 412 SARLTV 417
A L V
Sbjct: 3108 RAFLVV 3113
Score = 108 bits (270), Expect = 2e-23
Identities = 114/420 (27%), Positives = 169/420 (40%), Gaps = 43/420 (10%)
Query: 24 LLLLLLPAPSEGLGHSAELAFAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELP 83
L +LL P G SA+ V ++ PI L C P ITW K+G
Sbjct: 1249 LSVLLAPTILGGAEDSADEEVTVTVNN-------PISLICEALAFPSPNITWMKDGAPFE 1301
Query: 84 ESTHSTLL-ANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFH 142
S + LL L I + + E D G Y CV N G V S
Sbjct: 1302 ASRNIQLLPGTHGLQILNAQKE------DAGQYTCVVTNELGEAVKNYHVEVLIPPSISK 1355
Query: 143 VHPQATVGEE------GGVARFQCQIHGLPKPLITWEKNRVPIDTDNERYTLLPKG-VLQ 195
P A VG + +C+ +P P I W K+ P+ T + R +L +G +LQ
Sbjct: 1356 DDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPV-TPSSRLQVLGEGRLLQ 1414
Query: 196 ITGLRAEDGGIFHCVASNIA-------SIRISHGARLTVSGSGSGAYK-----EPAILVG 243
I + D G + CVA+N+A ++ I G S A++ E A
Sbjct: 1415 IQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGV 1474
Query: 244 PENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEGIQVLGTGNLI-ISDVTVQHS 302
E + + A L C P P ++W R D + + VL G ++ I V +++
Sbjct: 1475 TEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENA 1534
Query: 303 GVYVC-AANRPGTRVRRTAQGRLVVQAPAEFV----QHPQSISRPAGTTAMFTCQAQGEP 357
G Y C A+N G L+V P + + + ++ A +T C A G P
Sbjct: 1535 GRYSCKASNEVG---EDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNP 1591
Query: 358 PPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTV 417
P ++WL+NG P +++ + L +S D A Y CVAEN AGS++ L V
Sbjct: 1592 VPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRV 1651
Score = 104 bits (260), Expect = 3e-22
Identities = 106/392 (27%), Positives = 151/392 (38%), Gaps = 42/392 (10%)
Query: 49 SDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRLEPGGS 108
+D V V G + L C G P ++W K+G E S L G + +LE G+
Sbjct: 2132 NDVVVVRGSLVELPCEARGVPLPLVSWMKDG----EPLLSQSLEQGPSL----QLEAVGA 2183
Query: 109 PSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGE----EGGVARFQCQIHG 164
D G Y CVA + G + Q M H+ E G C G
Sbjct: 2184 -GDSGTYSCVAVSEAG---EARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQG 2239
Query: 165 LPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGAR 224
P+P ITW K D + T L LR D G++ C+A + A I R
Sbjct: 2240 TPQPNITWHK-------DGQALTRLENNSRATRVLRVRDAGLYTCLAESPAG-AIEKSFR 2291
Query: 225 LTVSGSGSGAYKEPAILVGPENLTLTVHQT---AVLECVATGNPRPIVSWSRLDGRPIGV 281
+ V + P +VGP V VLEC P P ++W R DG +
Sbjct: 2292 VRV--------QAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHR-DGIVLQE 2342
Query: 282 EG-IQVLGTGNLI-ISDVTVQHSGVYVCAA-NRPGTRVRRTAQGRLVVQAPAEFVQHPQS 338
+ Q G + + ++ SG Y C A N G+ + R+ + P +
Sbjct: 2343 DAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGS---TSVAFRVEIHTVPTIRSGPPA 2399
Query: 339 ISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIY 398
++ TA+ CQA G P P V+W K+ L P +L I + +D Y
Sbjct: 2400 VNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHY 2459
Query: 399 QCVAENSAGSSQASARLTVLWAEGLPGPPRNV 430
C+A NSAGS + L VL + P N+
Sbjct: 2460 LCLASNSAGSDRQGRDLRVLEPPAIAPSPSNL 2491
Score = 103 bits (258), Expect = 5e-22
Identities = 116/445 (26%), Positives = 171/445 (38%), Gaps = 68/445 (15%)
Query: 56 GQPIVLDCRVEGTPPVRITWRKN----GVELPESTHSTLLANGSLMIRHFRLEPGGS--- 108
GQ + L+C G P I W K+ GV L + + L G + H L+ G S
Sbjct: 33 GQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVG-GHRLLDEGQSLHF 91
Query: 109 ----PSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHV------------HPQATVGEE 152
D G Y C A+N+ G DFH+ Q +G
Sbjct: 92 PRIQEGDSGLYSCRAENQAG-----------TAQRDFHLLVLTPPSVLGAGAAQEVLGLA 140
Query: 153 GGVARFQCQIHGLPKPLITWEKNRVPIDTDNERYTLLPKG-VLQITGLRAEDGGIFHCVA 211
G QC G+P P + W K+R P+ + G VL+ITG D G + CVA
Sbjct: 141 GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVA 200
Query: 212 SNIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLE--CVATGNPRPIV 269
+ A + + +L V + P I E + V + +++ C A G P P +
Sbjct: 201 FSPAG-QQARDFQLRV-------HAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNI 252
Query: 270 SWSRLDGR--PIGVEGIQVLGTGNLIISDVTVQHSGVYVC-AANRPGTRVRRTAQGRLVV 326
+W + DG P + + G L + +GVY C A+N G + T RL V
Sbjct: 253 TWFK-DGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKAT---RLDV 308
Query: 327 QAPAEFV---QHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNS 383
P P + AG C A+G P P ++W G + RL+ + S
Sbjct: 309 YVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGS 368
Query: 384 TLTISGIGPEDEAIYQCVAENSAGSS--QASARLTV----LWAEGL------PGPPRNVR 431
L + G +Y CVA + AG + Q S + V L AEGL G P +
Sbjct: 369 VLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELP 428
Query: 432 AVSVSSTEVRVSWSEPLANTKEIIG 456
+ S + W + +E+ G
Sbjct: 429 CQASGSPVPTIQWLQNGRPAEELAG 453
Score = 103 bits (257), Expect = 6e-22
Identities = 96/391 (24%), Positives = 153/391 (39%), Gaps = 30/391 (7%)
Query: 41 ELAFAVEPSDDVAVPGQPIV-LDCRVEGTPPVRITWRKNGVELPESTHSTLLANG-SLMI 98
++A EP V+V + L+C G PP +TW ++G + L G SL +
Sbjct: 975 QIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHV 1034
Query: 99 RHFRLEPGGSPSDEGDYECVAQNRFGLVVSR---KARIQAATMSDFHVHPQATVGEEGGV 155
+ G Y CVA+N G + + + D T +
Sbjct: 1035 ER------AQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPL 1088
Query: 156 ARFQCQIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIA 215
C+ G+P P I W + P+ + Y L +L++T + +D G++ C+ASN A
Sbjct: 1089 TLL-CEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEA 1147
Query: 216 S-IRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRL 274
R + + V S E I V QTA L C TG+P+P ++W +
Sbjct: 1148 GEARRNFSVEVLVPPSIENEDLEEVIKV-------LDGQTAHLMCNVTGHPQPKLTWFK- 1199
Query: 275 DGRPIGVEGIQVLGTGNLIIS--DVTVQHSGVYVC-AANRPGTRVRRTAQGRLVVQAPAE 331
DGRP+ + +++ + +G Y C AAN G + + V+ AP
Sbjct: 1200 DGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLS--VLLAPTI 1257
Query: 332 FVQHPQSISRPAGTTA----MFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTI 387
S T C+A P P++TW+K+G +++L L I
Sbjct: 1258 LGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQI 1317
Query: 388 SGIGPEDEAIYQCVAENSAGSSQASARLTVL 418
ED Y CV N G + + + VL
Sbjct: 1318 LNAQKEDAGQYTCVVTNELGEAVKNYHVEVL 1348
Score = 92.4 bits (228), Expect = 1e-18
Identities = 108/411 (26%), Positives = 154/411 (37%), Gaps = 52/411 (12%)
Query: 54 VPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGS-LMIRHFRLEPGGSPSDE 112
+ GQP+ L C+ G+P I W +NG E + + G+ L I H L+ G
Sbjct: 420 IVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGL---- 475
Query: 113 GDYECVAQNRFGLV-----VSRKARIQAATM--------------SDFHVHPQATVGEEG 153
+ C A N G VS + S F V
Sbjct: 476 --FACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGW 533
Query: 154 GVARFQCQIHGLPKPLITW-EKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVAS 212
G + G P W E +P+ Y+L P LQI + D GI+ C A+
Sbjct: 534 GAHPKPPLVEGWCSPGSLWGEPTGIPV-----AYSLPPP--LQIEKVDLRDEGIYTCAAT 586
Query: 213 NIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWS 272
N+A A + P I GP N + + + LEC+A+G P P VSW
Sbjct: 587 NLAGESKREVALKVLV--------PPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWF 638
Query: 273 RLDGRPIGVEGIQVLGTGNLI-ISDVTVQHSGVYVC-AANRPGTRVRRTAQGRLVVQAPA 330
+ G+ V G ++ I + +G Y C A+N G+ R L V P
Sbjct: 639 KGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYG---LRVNVPP 695
Query: 331 EFVQHPQSISRPA--GTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLK--NNNSTLT 386
+ P S+ P T TC A G P P + WLK+G + P G L+ LT
Sbjct: 696 R-ITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLT 754
Query: 387 ISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAEGLPGPPRNVRAVSVSS 437
++ D Y CVA ++ G + L V + G NV V+ S
Sbjct: 755 LASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANES 805
Score = 82.0 bits (201), Expect = 2e-15
Identities = 73/274 (26%), Positives = 111/274 (40%), Gaps = 30/274 (10%)
Query: 44 FAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRL 103
F P D G + L C G+P RI W N + E GS + R
Sbjct: 2849 FTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQ--DGGSTLQR---- 2902
Query: 104 EPGGSPSDEGDYECVAQNRFG------LVVSRKARIQAATMSDFHVHPQATVGEEGGVAR 157
S D G Y C A+NR G V ++A + + V P GG +
Sbjct: 2903 -AAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEP------VGGSIQ 2955
Query: 158 FQCQIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASI 217
C + G P P I W K+ +P+ + R+ L G L I +D G + C+A N +
Sbjct: 2956 LDCVVRGDPVPDIHWIKDGLPLRGSHLRHQ-LQNGSLTIRRTERDDAGRYQCLAEN--EM 3012
Query: 218 RISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGR 277
++ + V S P V P+++T+ L C ATG P P + W + G+
Sbjct: 3013 GVAKKVVILVLQSA------PVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQA-GQ 3065
Query: 278 PI-GVEGIQVLGTGNLIISDVTVQHSGVYVCAAN 310
P+ ++ L G+L + +V +G Y C A+
Sbjct: 3066 PLRASRRLRTLPDGSLWLENVETGDAGTYDCVAH 3099
Score = 80.9 bits (198), Expect = 4e-15
Identities = 83/309 (26%), Positives = 125/309 (40%), Gaps = 34/309 (11%)
Query: 150 GEEGGVARFQCQIHGLPKPLITWEKNR----VPIDTDNERYTL----------LPKGV-L 194
G G +C +G P P I W K+ VP+ + L L +G L
Sbjct: 30 GMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSL 89
Query: 195 QITGLRAEDGGIFHCVASNIASI--RISHGARLTV-SGSGSGAYKEPAILVGPENLTLTV 251
++ D G++ C A N A R H LT S G+GA +E L G +
Sbjct: 90 HFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGAD------ 143
Query: 252 HQTAVLECVATGNPRPIVSWSRLDGRPI--GVEGIQVLGTGNLI-ISDVTVQHSGVYVCA 308
L+C +G P P V W++ D +P+ G +QV G ++ I+ V G Y C
Sbjct: 144 ---VELQCWTSGVPTPQVEWTK-DRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCV 199
Query: 309 ANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQ 368
A P + R Q R+ ++ C+A+G P P++TW K+G
Sbjct: 200 AFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGA 259
Query: 369 VLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTVL---WAEGLPG 425
+L V L + D +Y C A N+ G+++ + RL V EG G
Sbjct: 260 LLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGG 319
Query: 426 PPRNVRAVS 434
P V+AV+
Sbjct: 320 RPYVVKAVA 328
Score = 68.6 bits (166), Expect = 2e-11
Identities = 60/192 (31%), Positives = 86/192 (44%), Gaps = 23/192 (11%)
Query: 246 NLTLTVHQTAVLECVATGNPRPIVSW---SRLDGRPIG------------VEGIQVLGTG 290
N++ Q+ LEC A G P P + W ++L G P+G V G ++L G
Sbjct: 27 NVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEG 86
Query: 291 -NLIISDVTVQHSGVYVC-AANRPGTRVRRTAQGRLVVQAPAEFV--QHPQSISRPAGTT 346
+L + SG+Y C A N+ GT R L+V P + Q + AG
Sbjct: 87 QSLHFPRIQEGDSGLYSCRAENQAGTAQR---DFHLLVLTPPSVLGAGAAQEVLGLAGAD 143
Query: 347 AMFTCQAQGEPPPHVTWLKNGQVLGPGG-HVRLKNNNSTLTISGIGPEDEAIYQCVAENS 405
C G P P V W K+ Q + PGG H++++ + L I+G DE YQCVA +
Sbjct: 144 VELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSP 203
Query: 406 AGSSQASARLTV 417
AG +L V
Sbjct: 204 AGQQARDFQLRV 215
Score = 52.8 bits (125), Expect = 1e-06
Identities = 34/121 (28%), Positives = 52/121 (42%), Gaps = 17/121 (14%)
Query: 338 SISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLG----------------PGGHVRLKNN 381
++S AG + C A G P P + WLK+ Q++G GGH RL +
Sbjct: 27 NVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGH-RLLDE 85
Query: 382 NSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAEGLPGPPRNVRAVSVSSTEVR 441
+L I D +Y C AEN AG++Q L VL + G + ++ +V
Sbjct: 86 GQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVE 145
Query: 442 V 442
+
Sbjct: 146 L 146
Score = 48.5 bits (114), Expect = 2e-05
Identities = 30/86 (34%), Positives = 39/86 (45%), Gaps = 6/86 (6%)
Query: 44 FAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRL 103
F VEP D G + L C+ G P I W + G L S L +GSL + + +
Sbjct: 3029 FQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLEN--V 3086
Query: 104 EPGGSPSDEGDYECVAQNRFGLVVSR 129
E G D G Y+CVA N G +R
Sbjct: 3087 ETG----DAGTYDCVAHNLLGSATAR 3108
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 168 bits (425), Expect = 2e-41
Identities = 129/386 (33%), Positives = 173/386 (44%), Gaps = 30/386 (7%)
Query: 48 PSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPES-----THSTLLANGSLMIRHFR 102
PSD + G+P L+C+ EG P I W K G + +H LL +GSL R
Sbjct: 35 PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFF--LR 92
Query: 103 LEPGG-SPSDEGDYECVAQNRFGLVVSRKARIQAATM-SDFHVHPQATVGEEGGVARFQC 160
+ G S DEG Y CVA+N G VS A ++ A + DF +P + G A +C
Sbjct: 93 IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMEC 152
Query: 161 QI-HGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRI 219
Q G P+P I+W+K+ P+D +ER T+ G L IT R D G + CV +N+ R
Sbjct: 153 QPPRGHPEPTISWKKDGSPLDDKDERITIRG-GKLMITYTRKSDAGKYVCVGTNMVGERE 211
Query: 220 SHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPI 279
S A LTV + P+ + P NL +TV +A +C A G+P P V W + DG +
Sbjct: 212 SEVAELTV-------LERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE-L 263
Query: 280 GVEGIQVLGTGNLIISDVTVQHSGVYVCAA-NRPGTRVRRTAQGRLVVQAPAEFVQHPQS 338
++ L I VT G Y C A N G + A L VQ P FV P+
Sbjct: 264 PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVG---KAEASATLTVQEPPHFVVKPRD 320
Query: 339 ISRPAGTTAMFTCQAQGEPPPHVTWLKNG------QVLGPGGHVRLK-NNNSTLTISGIG 391
G T F C+A G P P + W + G P R + LTI+ +
Sbjct: 321 QVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQ 380
Query: 392 PEDEAIYQCVAENSAGSSQASARLTV 417
D Y C N AGS A L V
Sbjct: 381 RSDVGYYICQTLNVAGSIITKAYLEV 406
Score = 150 bits (379), Expect = 5e-36
Identities = 144/579 (24%), Positives = 226/579 (39%), Gaps = 70/579 (12%)
Query: 34 EGLGHSAELAFAV-------EPSDDVAVPGQPIVLDCRV-EGTPPVRITWRKNGVELPES 85
E + H+A L A+ PSD + G+P V++C+ G P I+W+K+G L +
Sbjct: 116 EAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDK 175
Query: 86 THSTLLANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHP 145
+ G LMI + R SD G Y CV N G S A + F P
Sbjct: 176 DERITIRGGKLMITYTR------KSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRP 229
Query: 146 QATVGEEGGVARFQCQIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGG 205
A F+C+ G P P + W K+ + RY + L+I + A D G
Sbjct: 230 SNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP--KSRYEIRDDHTLKIRKVTAGDMG 287
Query: 206 IFHCVASNIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNP 265
+ CVA N+ + A LTV + P +V P + + + +T +C ATGNP
Sbjct: 288 SYTCVAENMVG-KAEASATLTVQ-------EPPHFVVKPRDQVVALGRTVTFQCEATGNP 339
Query: 266 RPIVSWSRLDGR--------PIGVEGIQVLGTGNLIISDVTVQHSGVYVCAA-NRPGTRV 316
+P + W R + P V TG+L I++V G Y+C N G+ +
Sbjct: 340 QPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSII 399
Query: 317 RRT---AQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPG 373
+ + + P Q P + + T + +C A G P P + W K+G ++
Sbjct: 400 TKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQ 459
Query: 374 GHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTV------------LWAE 421
+ N L I D Y C+A +G + SA + V
Sbjct: 460 DSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPN 519
Query: 422 GLPGPPRNVRAVSVSSTEVRVSWSEPLANTKEIIGYVLHIRKAADPPELEYQEAVSKSTF 481
+P P VS V +SW L + Y++ A + A + T
Sbjct: 520 LIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQ-TVAENVKTE 578
Query: 482 QHLVSDLEPSTAYSFYIKAYTPRGASSAS-----------VPT--------LASTLGEAP 522
+ L+P+ Y F ++A G S S +PT + LG A
Sbjct: 579 TSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAV 638
Query: 523 APPPLSVRVLGSSSLQLLWEPWPRLAQHEGGFKLFYRPA 561
+ VL SSS+++ W + +Q+ G+K+ YRP+
Sbjct: 639 LHLH-NPTVLSSSSIEVHWTV-DQQSQYIQGYKILYRPS 675
Score = 120 bits (302), Expect = 4e-27
Identities = 93/287 (32%), Positives = 136/287 (47%), Gaps = 25/287 (8%)
Query: 144 HPQATVGEEGGVARFQCQIHGLPKPLITWEKNRVPIDTDNE----RYTLLPKGVL----Q 195
HP + +G A C+ G P P I W K ++TD + LLP G L
Sbjct: 34 HPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRI 93
Query: 196 ITGLRAE-DGGIFHCVASNIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQT 254
+ G ++ D G++ CVA N +SH A L V A P ++ + V +
Sbjct: 94 VHGRKSRPDEGVYVCVARNYLGEAVSHNASLEV------AILRDDFRQNPSDVMVAVGEP 147
Query: 255 AVLEC-VATGNPRPIVSWSRLDGRPIG--VEGIQVLGTGNLIISDVTVQHSGVYVC-AAN 310
AV+EC G+P P +SW + DG P+ E I + G G L+I+ +G YVC N
Sbjct: 148 AVMECQPPRGHPEPTISWKK-DGSPLDDKDERITIRG-GKLMITYTRKSDAGKYVCVGTN 205
Query: 311 RPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVL 370
G R A+ L V FV+ P +++ +A F C+A+G+P P V W K+ L
Sbjct: 206 MVGERESEVAE--LTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL 263
Query: 371 GPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTV 417
P +++++ TL I + D Y CVAEN G ++ASA LTV
Sbjct: 264 -PKSRYEIRDDH-TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 308
Score = 108 bits (271), Expect = 2e-23
Identities = 160/680 (23%), Positives = 259/680 (38%), Gaps = 76/680 (11%)
Query: 43 AFAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFR 102
+F PS+ C G P + WRK+ ELP+S + + + +L IR
Sbjct: 224 SFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYE-IRDDHTLKIRKV- 281
Query: 103 LEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQI 162
+ D G Y CVA+N G + A + F V P+ V G FQC+
Sbjct: 282 -----TAGDMGSYTCVAENMVGKAEA-SATLTVQEPPHFVVKPRDQVVALGRTVTFQCEA 335
Query: 163 HGLPKPLITWEKN-------RVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIA 215
G P+P I W + + R+++ G L IT ++ D G + C N+A
Sbjct: 336 TGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVA 395
Query: 216 SIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLD 275
I+ A L V+ + P I GP N T+ V T VL CVATG+P P + W R D
Sbjct: 396 GSIITK-AYLEVTDVIADR-PPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILW-RKD 452
Query: 276 GRPIGVEG--IQVLGTGNLIISDVTVQHSGVYVCAANRP---------------GTRVR- 317
G + + I+ L G L I + +G Y C A+ P G V+
Sbjct: 453 GVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQP 512
Query: 318 -RTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHV 376
R L+ AP++ +SR T + G P G
Sbjct: 513 PRPTDPNLIPSAPSK--PEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQT 570
Query: 377 RLKN-NNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAEGLPGPPRNVRAVSV 435
+N T I G+ P ++ A N+ G S S + + + + V V
Sbjct: 571 VAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQV 630
Query: 436 -----------------SSTEVRVSWSEPLANTKEIIGY-VLHIRKAADPPELEYQ--EA 475
SS+ + V W+ ++ I GY +L+ A+ E ++ E
Sbjct: 631 QRELGNAVLHLHNPTVLSSSSIEVHWTVD-QQSQYIQGYKILYRPSGANHGESDWLVFEV 689
Query: 476 VSKSTFQHLVSDLEPSTAYSFYIKAYTPRGASSASVPTLASTLGEAPAPPPLSVRVL--- 532
+ + ++ DL Y + + + S A TL EAP+ PP V V
Sbjct: 690 RTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKND 749
Query: 533 -GSSSLQLLWEPWPRLAQHEGGFKLFYRP---ASKTSFTGPILLPGTVSSYNLSQLDPTA 588
+++ + W+P P Q+ G Y+ ++T + + G+ S + L P
Sbjct: 750 GNGTAILVSWQPPPEDTQN--GMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGI 807
Query: 589 VYEVKLLAYNQHGDG-NATVRFVSLRGASERTALSPPCDCR-KEEAANQTSTTGIVIGIH 646
Y V++ A G G + +F+ L + +SP ++ ++ + G
Sbjct: 808 RYSVEVAASTGAGSGVKSEPQFIQL--DAHGNPVSPEDQVSLAQQISDVVKQPAFIAG-- 863
Query: 647 IGVTCIIFCVLFLLFGQRGR 666
IG C I ++F ++ R R
Sbjct: 864 IGAACWIILMVFSIWLYRHR 883
Score = 64.3 bits (155), Expect = 4e-10
Identities = 62/229 (27%), Positives = 93/229 (40%), Gaps = 20/229 (8%)
Query: 230 SGSGAYKE---PAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVE---- 282
SGS +E P I+ P +L ++ + A L C A G P P + W + G + +
Sbjct: 18 SGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYK-GGERVETDKDDP 76
Query: 283 --GIQVLGTGNLIISDV-----TVQHSGVYVCAA-NRPGTRVRRTAQGRLVVQAPAEFVQ 334
+L +G+L + + GVYVC A N G V A + + +F Q
Sbjct: 77 RSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD-DFRQ 135
Query: 335 HPQSISRPAGTTAMFTCQ-AQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPE 393
+P + G A+ CQ +G P P ++W K+G L R+ L I+
Sbjct: 136 NPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDE-RITIRGGKLMITYTRKS 194
Query: 394 DEAIYQCVAENSAGSSQAS-ARLTVLWAEGLPGPPRNVRAVSVSSTEVR 441
D Y CV N G ++ A LTVL P N+ S E +
Sbjct: 195 DAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFK 243
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 168 bits (425), Expect = 2e-41
Identities = 129/386 (33%), Positives = 173/386 (44%), Gaps = 30/386 (7%)
Query: 48 PSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPES-----THSTLLANGSLMIRHFR 102
PSD + G+P L+C+ EG P I W K G + +H LL +GSL R
Sbjct: 74 PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFF--LR 131
Query: 103 LEPGG-SPSDEGDYECVAQNRFGLVVSRKARIQAATM-SDFHVHPQATVGEEGGVARFQC 160
+ G S DEG Y CVA+N G VS A ++ A + DF +P + G A +C
Sbjct: 132 IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMEC 191
Query: 161 QI-HGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRI 219
Q G P+P I+W+K+ P+D +ER T+ G L IT R D G + CV +N+ R
Sbjct: 192 QPPRGHPEPTISWKKDGSPLDDKDERITIRG-GKLMITYTRKSDAGKYVCVGTNMVGERE 250
Query: 220 SHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPI 279
S A LTV + P+ + P NL +TV +A +C A G+P P V W + DG +
Sbjct: 251 SEVAELTV-------LERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE-L 302
Query: 280 GVEGIQVLGTGNLIISDVTVQHSGVYVCAA-NRPGTRVRRTAQGRLVVQAPAEFVQHPQS 338
++ L I VT G Y C A N G + A L VQ P FV P+
Sbjct: 303 PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVG---KAEASATLTVQEPPHFVVKPRD 359
Query: 339 ISRPAGTTAMFTCQAQGEPPPHVTWLKNG------QVLGPGGHVRLK-NNNSTLTISGIG 391
G T F C+A G P P + W + G P R + LTI+ +
Sbjct: 360 QVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQ 419
Query: 392 PEDEAIYQCVAENSAGSSQASARLTV 417
D Y C N AGS A L V
Sbjct: 420 RSDVGYYICQTLNVAGSIITKAYLEV 445
Score = 150 bits (379), Expect = 5e-36
Identities = 144/579 (24%), Positives = 226/579 (39%), Gaps = 70/579 (12%)
Query: 34 EGLGHSAELAFAV-------EPSDDVAVPGQPIVLDCRV-EGTPPVRITWRKNGVELPES 85
E + H+A L A+ PSD + G+P V++C+ G P I+W+K+G L +
Sbjct: 155 EAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDK 214
Query: 86 THSTLLANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHP 145
+ G LMI + R SD G Y CV N G S A + F P
Sbjct: 215 DERITIRGGKLMITYTR------KSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRP 268
Query: 146 QATVGEEGGVARFQCQIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGG 205
A F+C+ G P P + W K+ + RY + L+I + A D G
Sbjct: 269 SNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP--KSRYEIRDDHTLKIRKVTAGDMG 326
Query: 206 IFHCVASNIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNP 265
+ CVA N+ + A LTV + P +V P + + + +T +C ATGNP
Sbjct: 327 SYTCVAENMVG-KAEASATLTVQ-------EPPHFVVKPRDQVVALGRTVTFQCEATGNP 378
Query: 266 RPIVSWSRLDGR--------PIGVEGIQVLGTGNLIISDVTVQHSGVYVCAA-NRPGTRV 316
+P + W R + P V TG+L I++V G Y+C N G+ +
Sbjct: 379 QPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSII 438
Query: 317 RRT---AQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPG 373
+ + + P Q P + + T + +C A G P P + W K+G ++
Sbjct: 439 TKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQ 498
Query: 374 GHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTV------------LWAE 421
+ N L I D Y C+A +G + SA + V
Sbjct: 499 DSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPN 558
Query: 422 GLPGPPRNVRAVSVSSTEVRVSWSEPLANTKEIIGYVLHIRKAADPPELEYQEAVSKSTF 481
+P P VS V +SW L + Y++ A + A + T
Sbjct: 559 LIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQ-TVAENVKTE 617
Query: 482 QHLVSDLEPSTAYSFYIKAYTPRGASSAS-----------VPT--------LASTLGEAP 522
+ L+P+ Y F ++A G S S +PT + LG A
Sbjct: 618 TSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAV 677
Query: 523 APPPLSVRVLGSSSLQLLWEPWPRLAQHEGGFKLFYRPA 561
+ VL SSS+++ W + +Q+ G+K+ YRP+
Sbjct: 678 LHLH-NPTVLSSSSIEVHWTV-DQQSQYIQGYKILYRPS 714
Score = 120 bits (302), Expect = 4e-27
Identities = 93/287 (32%), Positives = 136/287 (47%), Gaps = 25/287 (8%)
Query: 144 HPQATVGEEGGVARFQCQIHGLPKPLITWEKNRVPIDTDNE----RYTLLPKGVL----Q 195
HP + +G A C+ G P P I W K ++TD + LLP G L
Sbjct: 73 HPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRI 132
Query: 196 ITGLRAE-DGGIFHCVASNIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQT 254
+ G ++ D G++ CVA N +SH A L V A P ++ + V +
Sbjct: 133 VHGRKSRPDEGVYVCVARNYLGEAVSHNASLEV------AILRDDFRQNPSDVMVAVGEP 186
Query: 255 AVLEC-VATGNPRPIVSWSRLDGRPIG--VEGIQVLGTGNLIISDVTVQHSGVYVC-AAN 310
AV+EC G+P P +SW + DG P+ E I + G G L+I+ +G YVC N
Sbjct: 187 AVMECQPPRGHPEPTISWKK-DGSPLDDKDERITIRG-GKLMITYTRKSDAGKYVCVGTN 244
Query: 311 RPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVL 370
G R A+ L V FV+ P +++ +A F C+A+G+P P V W K+ L
Sbjct: 245 MVGERESEVAE--LTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL 302
Query: 371 GPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTV 417
P +++++ TL I + D Y CVAEN G ++ASA LTV
Sbjct: 303 -PKSRYEIRDDH-TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 347
Score = 108 bits (271), Expect = 2e-23
Identities = 160/680 (23%), Positives = 259/680 (38%), Gaps = 76/680 (11%)
Query: 43 AFAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFR 102
+F PS+ C G P + WRK+ ELP+S + + + +L IR
Sbjct: 263 SFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYE-IRDDHTLKIRKV- 320
Query: 103 LEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQI 162
+ D G Y CVA+N G + A + F V P+ V G FQC+
Sbjct: 321 -----TAGDMGSYTCVAENMVGKAEA-SATLTVQEPPHFVVKPRDQVVALGRTVTFQCEA 374
Query: 163 HGLPKPLITWEKN-------RVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIA 215
G P+P I W + + R+++ G L IT ++ D G + C N+A
Sbjct: 375 TGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVA 434
Query: 216 SIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLD 275
I+ A L V+ + P I GP N T+ V T VL CVATG+P P + W R D
Sbjct: 435 GSIITK-AYLEVTDVIADR-PPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILW-RKD 491
Query: 276 GRPIGVEG--IQVLGTGNLIISDVTVQHSGVYVCAANRP---------------GTRVR- 317
G + + I+ L G L I + +G Y C A+ P G V+
Sbjct: 492 GVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQP 551
Query: 318 -RTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHV 376
R L+ AP++ +SR T + G P G
Sbjct: 552 PRPTDPNLIPSAPSK--PEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQT 609
Query: 377 RLKN-NNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAEGLPGPPRNVRAVSV 435
+N T I G+ P ++ A N+ G S S + + + + V V
Sbjct: 610 VAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQV 669
Query: 436 -----------------SSTEVRVSWSEPLANTKEIIGY-VLHIRKAADPPELEYQ--EA 475
SS+ + V W+ ++ I GY +L+ A+ E ++ E
Sbjct: 670 QRELGNAVLHLHNPTVLSSSSIEVHWTVD-QQSQYIQGYKILYRPSGANHGESDWLVFEV 728
Query: 476 VSKSTFQHLVSDLEPSTAYSFYIKAYTPRGASSASVPTLASTLGEAPAPPPLSVRVL--- 532
+ + ++ DL Y + + + S A TL EAP+ PP V V
Sbjct: 729 RTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKND 788
Query: 533 -GSSSLQLLWEPWPRLAQHEGGFKLFYRP---ASKTSFTGPILLPGTVSSYNLSQLDPTA 588
+++ + W+P P Q+ G Y+ ++T + + G+ S + L P
Sbjct: 789 GNGTAILVSWQPPPEDTQN--GMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGI 846
Query: 589 VYEVKLLAYNQHGDG-NATVRFVSLRGASERTALSPPCDCR-KEEAANQTSTTGIVIGIH 646
Y V++ A G G + +F+ L + +SP ++ ++ + G
Sbjct: 847 RYSVEVAASTGAGSGVKSEPQFIQL--DAHGNPVSPEDQVSLAQQISDVVKQPAFIAG-- 902
Query: 647 IGVTCIIFCVLFLLFGQRGR 666
IG C I ++F ++ R R
Sbjct: 903 IGAACWIILMVFSIWLYRHR 922
Score = 63.9 bits (154), Expect = 6e-10
Identities = 58/218 (26%), Positives = 88/218 (40%), Gaps = 17/218 (7%)
Query: 238 PAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVE------GIQVLGTGN 291
P I+ P +L ++ + A L C A G P P + W + G + + +L +G+
Sbjct: 68 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYK-GGERVETDKDDPRSHRMLLPSGS 126
Query: 292 LIISDV-----TVQHSGVYVCAA-NRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGT 345
L + + GVYVC A N G V A + + +F Q+P + G
Sbjct: 127 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD-DFRQNPSDVMVAVGE 185
Query: 346 TAMFTCQ-AQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAEN 404
A+ CQ +G P P ++W K+G L R+ L I+ D Y CV N
Sbjct: 186 PAVMECQPPRGHPEPTISWKKDGSPLDDKDE-RITIRGGKLMITYTRKSDAGKYVCVGTN 244
Query: 405 SAGSSQAS-ARLTVLWAEGLPGPPRNVRAVSVSSTEVR 441
G ++ A LTVL P N+ S E +
Sbjct: 245 MVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFK 282
Score = 47.0 bits (110), Expect = 7e-05
Identities = 30/102 (29%), Positives = 43/102 (42%), Gaps = 12/102 (11%)
Query: 329 PAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVL-----GPGGHVRLKNNNS 383
P V+HP + G A C+A+G P P + W K G+ + P H L + S
Sbjct: 67 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 126
Query: 384 TLTISGI----GPEDEAIYQCVAENSAG---SSQASARLTVL 418
+ + DE +Y CVA N G S AS + +L
Sbjct: 127 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAIL 168
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 167 bits (423), Expect = 4e-41
Identities = 132/387 (34%), Positives = 178/387 (45%), Gaps = 32/387 (8%)
Query: 48 PSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPES-----THSTLLANGSLMIRHFR 102
PSD + G+P L+C+ EG P I W K+G + +H LL +GSL R
Sbjct: 53 PSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFF--LR 110
Query: 103 LEPGG-SPSDEGDYECVAQNRFGLVVSRKARIQAATM-SDFHVHPQATVGEEGGVARFQC 160
+ G S DEG Y CVA+N G VSR A ++ A + DF +P V G A +C
Sbjct: 111 IVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILEC 170
Query: 161 QI-HGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRI 219
Q G P+P I W+K++V ID ER ++ G L I+ R D G++ CV +N+ R
Sbjct: 171 QPPRGHPEPTIYWKKDKVRIDDKEERISIRG-GKLMISNTRKSDAGMYTCVGTNMVGERD 229
Query: 220 SHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGR-P 278
S A LTV ++ P L P N + + C G+P+P V W + D P
Sbjct: 230 SDPAELTV-------FERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLP 282
Query: 279 IGVEGIQVLGTGNLIISDVTVQHSGVYVCAA-NRPGTRVRRTAQGRLVVQAPAEFVQHPQ 337
G I+ T L I G Y+C A NR G + A L V+AP +FV P+
Sbjct: 283 RGRYDIKDDYT--LRIKKTMSTDEGTYMCIAENRVG---KMEASATLTVRAPPQFVVRPR 337
Query: 338 SISRPAGTTAMFTCQAQGEPPPHVTWLKNG--QVLGPGGHVRLKNNNST-----LTISGI 390
G T F C+ +G P P V W K G +L P + + S LTI+ I
Sbjct: 338 DQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNI 397
Query: 391 GPEDEAIYQCVAENSAGSSQASARLTV 417
D Y C A AGS A A+L V
Sbjct: 398 QRSDAGYYICQALTVAGSILAKAQLEV 424
Score = 167 bits (423), Expect = 4e-41
Identities = 158/610 (25%), Positives = 238/610 (39%), Gaps = 85/610 (13%)
Query: 44 FAVEPSDDVAVPGQPIVLDCRV-EGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFR 102
F P+D V G+P +L+C+ G P I W+K+ V + + + G LMI + R
Sbjct: 151 FRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTR 210
Query: 103 LEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQI 162
SD G Y CV N G S A + F P V E F+CQ+
Sbjct: 211 ------KSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQV 264
Query: 163 HGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHG 222
G P+P + W+K+ D RY + L+I + D G + C+A N ++
Sbjct: 265 QGDPQPTVRWKKDDA--DLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVG-KMEAS 321
Query: 223 ARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVE 282
A LTV P +V P + + +T C GNP+P V W + + +
Sbjct: 322 ATLTVRAP-------PQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFP 374
Query: 283 G--------IQVLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGR----LVVQAPA 330
V TG+L I+++ +G Y+C A + AQ L + P
Sbjct: 375 NQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPP 434
Query: 331 EFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLK-NNNSTLTISG 389
+Q P + + TA+ C+A G+P P ++WLK G PG R TL I
Sbjct: 435 IILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTF-PGRDPRATIQEQGTLQIKN 493
Query: 390 IGPEDEAIYQCVAENSAGSSQASARLTVLWA----------EGLPGPPRNVRAVSVSSTE 439
+ D Y CVA +S+G + SA L V + LPGPP + V+
Sbjct: 494 LRISDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNS 553
Query: 440 VRVSWSEPLANTKEIIGYVLHIRKAADPPELEYQEAVSKS---------TFQHLVSDLEP 490
V +SW T Y++ + ++VS S T + V L P
Sbjct: 554 VTLSWQPGTPGTLPASAYIIE----------AFSQSVSNSWQTVANHVKTTLYTVRGLRP 603
Query: 491 STAYSFYIKAYTPRGASSASVPTLASTLGEAPAPPPLSVR-------------------V 531
+T Y F ++A P+G S S P + +PP V V
Sbjct: 604 NTIYLFMVRAINPQGLSDPS-PMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVV 662
Query: 532 LGSSSLQLLWEPWPRLAQHEGGFKLFYRPAS----KTSFTGPILLPGTVSSYNLSQLDPT 587
L +++Q+ W R Q G+++ YR S +S+ T S L L
Sbjct: 663 LTPTTVQVTWTV-DRQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKG 721
Query: 588 AVYEVKLLAY 597
YE+K+ Y
Sbjct: 722 VTYEIKVRPY 731
Score = 127 bits (320), Expect = 3e-29
Identities = 159/710 (22%), Positives = 274/710 (38%), Gaps = 77/710 (10%)
Query: 44 FAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRL 103
F P + V + + + C+V+G P + W+K+ +LP + + + +L I+
Sbjct: 243 FLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGRYD-IKDDYTLRIKKTM- 300
Query: 104 EPGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQIH 163
+DEG Y C+A+NR G + + A + F V P+ + +G F C+
Sbjct: 301 -----STDEGTYMCIAENRVGKMEA-SATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETK 354
Query: 164 GLPKPLITWEKNRVPI-------DTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIAS 216
G P+P + W+K N R ++ P G L IT ++ D G + C A +A
Sbjct: 355 GNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAG 414
Query: 217 IRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSR--- 273
++ A+L V+ + P IL GP N TL V TA+L+C ATG+P P++SW +
Sbjct: 415 SILAK-AQLEVTDVLTDR-PPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGF 472
Query: 274 -LDGRPIGVEGIQVLGTGNLIISDVTVQHSGVYVCAANRPG-----TRVRRTAQGRLVVQ 327
GR IQ GT L I ++ + +G Y C A + V + +
Sbjct: 473 TFPGRDPRAT-IQEQGT--LQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATIS 529
Query: 328 APAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTL-- 385
+ P S+P T P L + + N+ T+
Sbjct: 530 KNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSWQTVAN 589
Query: 386 -------TISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAEGLPGPPRNV-------- 430
T+ G+ P ++ A N G S S + + + P + V
Sbjct: 590 HVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKE 649
Query: 431 ---------RAVSVSSTEVRVSWSEPLANTKEIIGY-VLHIRKAADPPELEYQEAVSKST 480
V ++ T V+V+W+ + I GY V++ + + +Q +K
Sbjct: 650 LGDVLVRLHNPVVLTPTTVQVTWTVD-RQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVP 708
Query: 481 FQH--LVSDLEPSTAYSFYIKAYTPRGASSASVPTLASTLGEAPAPPPLSVRVL-----G 533
+ ++ +L+ Y ++ Y S T EAP+ PP SV VL
Sbjct: 709 TERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYN 768
Query: 534 SSSLQLLWEPWPRLAQHEGGFKLFYR---PASKTSFTGPILLPGTVSSYNLSQLDPTAVY 590
S+S+ + W+P P H+ G Y+ ++T F + + S + L P Y
Sbjct: 769 STSISVSWDPPP--PDHQNGIIQEYKIWCLGNETRFHINKTVDAAIRSVIIGGLFPGIQY 826
Query: 591 EVKLLAYNQHGDGNATVRFVSLRGASERTALSPPCDCRKEEAANQTSTTGIVIGIHIGVT 650
V++ A G G + + G ++ + E+ + + G IG
Sbjct: 827 RVEVAASTSAGVGVKSEPQPIIIGRRNEVVITENNNSITEQITDVVKQPAFIAG--IGGA 884
Query: 651 CIIFCVLFLLFGQRGRVLLCKDVENQLSPPQGPRSQRDPGILALNGARRG 700
C + + F ++ L + + + QR G L NG+R G
Sbjct: 885 CWVILMGFSIW------LYWRRKKRKGLSNYAVTFQRGDGGLMSNGSRPG 928
Score = 105 bits (262), Expect = 2e-22
Identities = 90/289 (31%), Positives = 127/289 (43%), Gaps = 29/289 (10%)
Query: 144 HPQATVGEEGGVARFQCQIHGLPKPLITWEKNRVPIDTDNE----RYTLLPKGVL----Q 195
HP + +G C+ G P P I W K+ ++TD + LLP G L
Sbjct: 52 HPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRI 111
Query: 196 ITGLRAE-DGGIFHCVASNIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQT 254
+ G R++ D G + CVA N +S A L V A P ++ + +
Sbjct: 112 VHGRRSKPDEGSYVCVARNYLGEAVSRNASLEV------ALLRDDFRQNPTDVVVAAGEP 165
Query: 255 AVLEC-VATGNPRPIVSWS----RLDGRPIGVEGIQVLGTGNLIISDVTVQHSGVYVC-A 308
A+LEC G+P P + W R+D + E I + G G L+IS+ +G+Y C
Sbjct: 166 AILECQPPRGHPEPTIYWKKDKVRIDDKE---ERISIRG-GKLMISNTRKSDAGMYTCVG 221
Query: 309 ANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQ 368
N G R A+ L V F++ P + F CQ QG+P P V W K+
Sbjct: 222 TNMVGERDSDPAE--LTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDA 279
Query: 369 VLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTV 417
L P G +K ++ TL I DE Y C+AEN G +ASA LTV
Sbjct: 280 DL-PRGRYDIK-DDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTV 326
Score = 60.1 bits (144), Expect = 8e-09
Identities = 57/206 (27%), Positives = 85/206 (41%), Gaps = 20/206 (9%)
Query: 229 GSGSGAYKE---PAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVE--- 282
G GS +E P I+ P ++ ++ + L C A G P P + W + DG + +
Sbjct: 35 GQGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYK-DGERVETDKDD 93
Query: 283 ---GIQVLGTGNLIISDV-----TVQHSGVYVCAA-NRPGTRVRRTAQGRLVVQAPAEFV 333
+L +G+L + + G YVC A N G V R A + + +F
Sbjct: 94 PRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRD-DFR 152
Query: 334 QHPQSISRPAGTTAMFTCQ-AQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGP 392
Q+P + AG A+ CQ +G P P + W K +V R+ L IS
Sbjct: 153 QNPTDVVVAAGEPAILECQPPRGHPEPTIYW-KKDKVRIDDKEERISIRGGKLMISNTRK 211
Query: 393 EDEAIYQCVAENSAGSSQAS-ARLTV 417
D +Y CV N G + A LTV
Sbjct: 212 SDAGMYTCVGTNMVGERDSDPAELTV 237
Score = 43.9 bits (102), Expect = 6e-04
Identities = 29/102 (28%), Positives = 42/102 (41%), Gaps = 12/102 (11%)
Query: 329 PAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVL-----GPGGHVRLKNNNS 383
P V+HP + G C+A+G P P + W K+G+ + P H L + S
Sbjct: 46 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 105
Query: 384 TLTISGI----GPEDEAIYQCVAENSAG---SSQASARLTVL 418
+ + DE Y CVA N G S AS + +L
Sbjct: 106 LFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALL 147
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 167 bits (423), Expect = 4e-41
Identities = 132/387 (34%), Positives = 178/387 (45%), Gaps = 32/387 (8%)
Query: 48 PSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPES-----THSTLLANGSLMIRHFR 102
PSD + G+P L+C+ EG P I W K+G + +H LL +GSL R
Sbjct: 37 PSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFF--LR 94
Query: 103 LEPGG-SPSDEGDYECVAQNRFGLVVSRKARIQAATM-SDFHVHPQATVGEEGGVARFQC 160
+ G S DEG Y CVA+N G VSR A ++ A + DF +P V G A +C
Sbjct: 95 IVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILEC 154
Query: 161 QI-HGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRI 219
Q G P+P I W+K++V ID ER ++ G L I+ R D G++ CV +N+ R
Sbjct: 155 QPPRGHPEPTIYWKKDKVRIDDKEERISIRG-GKLMISNTRKSDAGMYTCVGTNMVGERD 213
Query: 220 SHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGR-P 278
S A LTV ++ P L P N + + C G+P+P V W + D P
Sbjct: 214 SDPAELTV-------FERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLP 266
Query: 279 IGVEGIQVLGTGNLIISDVTVQHSGVYVCAA-NRPGTRVRRTAQGRLVVQAPAEFVQHPQ 337
G I+ T L I G Y+C A NR G + A L V+AP +FV P+
Sbjct: 267 RGRYDIKDDYT--LRIKKTMSTDEGTYMCIAENRVG---KMEASATLTVRAPPQFVVRPR 321
Query: 338 SISRPAGTTAMFTCQAQGEPPPHVTWLKNG--QVLGPGGHVRLKNNNST-----LTISGI 390
G T F C+ +G P P V W K G +L P + + S LTI+ I
Sbjct: 322 DQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNI 381
Query: 391 GPEDEAIYQCVAENSAGSSQASARLTV 417
D Y C A AGS A A+L V
Sbjct: 382 QRSDAGYYICQALTVAGSILAKAQLEV 408
Score = 167 bits (423), Expect = 4e-41
Identities = 158/610 (25%), Positives = 238/610 (39%), Gaps = 85/610 (13%)
Query: 44 FAVEPSDDVAVPGQPIVLDCRV-EGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFR 102
F P+D V G+P +L+C+ G P I W+K+ V + + + G LMI + R
Sbjct: 135 FRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTR 194
Query: 103 LEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQI 162
SD G Y CV N G S A + F P V E F+CQ+
Sbjct: 195 ------KSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQV 248
Query: 163 HGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHG 222
G P+P + W+K+ D RY + L+I + D G + C+A N ++
Sbjct: 249 QGDPQPTVRWKKDDA--DLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVG-KMEAS 305
Query: 223 ARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVE 282
A LTV P +V P + + +T C GNP+P V W + + +
Sbjct: 306 ATLTVRAP-------PQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFP 358
Query: 283 G--------IQVLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGR----LVVQAPA 330
V TG+L I+++ +G Y+C A + AQ L + P
Sbjct: 359 NQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPP 418
Query: 331 EFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLK-NNNSTLTISG 389
+Q P + + TA+ C+A G+P P ++WLK G PG R TL I
Sbjct: 419 IILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTF-PGRDPRATIQEQGTLQIKN 477
Query: 390 IGPEDEAIYQCVAENSAGSSQASARLTVLWA----------EGLPGPPRNVRAVSVSSTE 439
+ D Y CVA +S+G + SA L V + LPGPP + V+
Sbjct: 478 LRISDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNS 537
Query: 440 VRVSWSEPLANTKEIIGYVLHIRKAADPPELEYQEAVSKS---------TFQHLVSDLEP 490
V +SW T Y++ + ++VS S T + V L P
Sbjct: 538 VTLSWQPGTPGTLPASAYIIE----------AFSQSVSNSWQTVANHVKTTLYTVRGLRP 587
Query: 491 STAYSFYIKAYTPRGASSASVPTLASTLGEAPAPPPLSVR-------------------V 531
+T Y F ++A P+G S S P + +PP V V
Sbjct: 588 NTIYLFMVRAINPQGLSDPS-PMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVV 646
Query: 532 LGSSSLQLLWEPWPRLAQHEGGFKLFYRPAS----KTSFTGPILLPGTVSSYNLSQLDPT 587
L +++Q+ W R Q G+++ YR S +S+ T S L L
Sbjct: 647 LTPTTVQVTWTV-DRQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKG 705
Query: 588 AVYEVKLLAY 597
YE+K+ Y
Sbjct: 706 VTYEIKVRPY 715
Score = 127 bits (320), Expect = 3e-29
Identities = 159/710 (22%), Positives = 274/710 (38%), Gaps = 77/710 (10%)
Query: 44 FAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRL 103
F P + V + + + C+V+G P + W+K+ +LP + + + +L I+
Sbjct: 227 FLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGRYD-IKDDYTLRIKKTM- 284
Query: 104 EPGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQIH 163
+DEG Y C+A+NR G + + A + F V P+ + +G F C+
Sbjct: 285 -----STDEGTYMCIAENRVGKMEA-SATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETK 338
Query: 164 GLPKPLITWEKNRVPI-------DTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIAS 216
G P+P + W+K N R ++ P G L IT ++ D G + C A +A
Sbjct: 339 GNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAG 398
Query: 217 IRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSR--- 273
++ A+L V+ + P IL GP N TL V TA+L+C ATG+P P++SW +
Sbjct: 399 SILAK-AQLEVTDVLTDR-PPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGF 456
Query: 274 -LDGRPIGVEGIQVLGTGNLIISDVTVQHSGVYVCAANRPG-----TRVRRTAQGRLVVQ 327
GR IQ GT L I ++ + +G Y C A + V + +
Sbjct: 457 TFPGRDPRAT-IQEQGT--LQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATIS 513
Query: 328 APAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTL-- 385
+ P S+P T P L + + N+ T+
Sbjct: 514 KNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSWQTVAN 573
Query: 386 -------TISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAEGLPGPPRNV-------- 430
T+ G+ P ++ A N G S S + + + P + V
Sbjct: 574 HVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKE 633
Query: 431 ---------RAVSVSSTEVRVSWSEPLANTKEIIGY-VLHIRKAADPPELEYQEAVSKST 480
V ++ T V+V+W+ + I GY V++ + + +Q +K
Sbjct: 634 LGDVLVRLHNPVVLTPTTVQVTWTVD-RQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVP 692
Query: 481 FQH--LVSDLEPSTAYSFYIKAYTPRGASSASVPTLASTLGEAPAPPPLSVRVL-----G 533
+ ++ +L+ Y ++ Y S T EAP+ PP SV VL
Sbjct: 693 TERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYN 752
Query: 534 SSSLQLLWEPWPRLAQHEGGFKLFYR---PASKTSFTGPILLPGTVSSYNLSQLDPTAVY 590
S+S+ + W+P P H+ G Y+ ++T F + + S + L P Y
Sbjct: 753 STSISVSWDPPP--PDHQNGIIQEYKIWCLGNETRFHINKTVDAAIRSVIIGGLFPGIQY 810
Query: 591 EVKLLAYNQHGDGNATVRFVSLRGASERTALSPPCDCRKEEAANQTSTTGIVIGIHIGVT 650
V++ A G G + + G ++ + E+ + + G IG
Sbjct: 811 RVEVAASTSAGVGVKSEPQPIIIGRRNEVVITENNNSITEQITDVVKQPAFIAG--IGGA 868
Query: 651 CIIFCVLFLLFGQRGRVLLCKDVENQLSPPQGPRSQRDPGILALNGARRG 700
C + + F ++ L + + + QR G L NG+R G
Sbjct: 869 CWVILMGFSIW------LYWRRKKRKGLSNYAVTFQRGDGGLMSNGSRPG 912
Score = 105 bits (262), Expect = 2e-22
Identities = 90/289 (31%), Positives = 127/289 (43%), Gaps = 29/289 (10%)
Query: 144 HPQATVGEEGGVARFQCQIHGLPKPLITWEKNRVPIDTDNE----RYTLLPKGVL----Q 195
HP + +G C+ G P P I W K+ ++TD + LLP G L
Sbjct: 36 HPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRI 95
Query: 196 ITGLRAE-DGGIFHCVASNIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQT 254
+ G R++ D G + CVA N +S A L V A P ++ + +
Sbjct: 96 VHGRRSKPDEGSYVCVARNYLGEAVSRNASLEV------ALLRDDFRQNPTDVVVAAGEP 149
Query: 255 AVLEC-VATGNPRPIVSWS----RLDGRPIGVEGIQVLGTGNLIISDVTVQHSGVYVC-A 308
A+LEC G+P P + W R+D + E I + G G L+IS+ +G+Y C
Sbjct: 150 AILECQPPRGHPEPTIYWKKDKVRIDDKE---ERISIRG-GKLMISNTRKSDAGMYTCVG 205
Query: 309 ANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQ 368
N G R A+ L V F++ P + F CQ QG+P P V W K+
Sbjct: 206 TNMVGERDSDPAE--LTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDA 263
Query: 369 VLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTV 417
L P G +K ++ TL I DE Y C+AEN G +ASA LTV
Sbjct: 264 DL-PRGRYDIK-DDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTV 310
Score = 58.9 bits (141), Expect = 2e-08
Identities = 53/194 (27%), Positives = 80/194 (41%), Gaps = 17/194 (8%)
Query: 238 PAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVE------GIQVLGTGN 291
P I+ P ++ ++ + L C A G P P + W + DG + + +L +G+
Sbjct: 31 PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYK-DGERVETDKDDPRSHRMLLPSGS 89
Query: 292 LIISDV-----TVQHSGVYVCAA-NRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGT 345
L + + G YVC A N G V R A + + +F Q+P + AG
Sbjct: 90 LFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRD-DFRQNPTDVVVAAGE 148
Query: 346 TAMFTCQ-AQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAEN 404
A+ CQ +G P P + W K +V R+ L IS D +Y CV N
Sbjct: 149 PAILECQPPRGHPEPTIYW-KKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTN 207
Query: 405 SAGSSQAS-ARLTV 417
G + A LTV
Sbjct: 208 MVGERDSDPAELTV 221
Score = 43.9 bits (102), Expect = 6e-04
Identities = 29/102 (28%), Positives = 42/102 (41%), Gaps = 12/102 (11%)
Query: 329 PAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVL-----GPGGHVRLKNNNS 383
P V+HP + G C+A+G P P + W K+G+ + P H L + S
Sbjct: 30 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 89
Query: 384 TLTISGI----GPEDEAIYQCVAENSAG---SSQASARLTVL 418
+ + DE Y CVA N G S AS + +L
Sbjct: 90 LFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALL 131
>gi|7657361 contactin 6 [Homo sapiens]
Length = 1028
Score = 164 bits (414), Expect = 4e-40
Identities = 131/422 (31%), Positives = 188/422 (44%), Gaps = 41/422 (9%)
Query: 19 RLLLPLLLLL-LPAPSEGLGHSAELAFAVEPSDDVA---VPGQPIVLDCRVEGTPPVRIT 74
RLL L++LL L S G G + F EP D + + ++L+C G P
Sbjct: 2 RLLWKLVILLPLINSSAGDGLLSRPIFTQEPHDVIFPLDLSKSEVILNCAANGYPSPHYR 61
Query: 75 WRKNGVELPESTHSTLLANGSLMIRHFRLEPGG-------SPSDEGDYECVAQNRFGLVV 127
W++NG ++ + M H+RL+ G + D G Y+C+A N G ++
Sbjct: 62 WKQNGTDIDFT-----------MSYHYRLDGGSLAINSPHTDQDIGMYQCLATNLLGTIL 110
Query: 128 SRKARIQAATMSDFHVHPQATVG-EEGGVARFQCQIHGLPKPLI-------TWEKNRVPI 179
SRKA++Q A + DF ++TV EG C P P T+ N + +
Sbjct: 111 SRKAKLQFAYIEDFETKTRSTVSVREGQGVVLLCG----PPPHFGDLSYAWTFNDNPLYV 166
Query: 180 DTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHG--ARLTVSGSGSGAYKE 237
DN R+ G L I + D G + C +N + R G L G E
Sbjct: 167 QEDNRRFVSQETGNLYIAKVEPSDVGNYTCFITNKEAQRSVQGPPTPLVQRTDGVMGEYE 226
Query: 238 PAILVG-PENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEGIQVLGTGNLIISD 296
P I V PE + + LEC A GNP P +SW RLDG P+ + L I +
Sbjct: 227 PKIEVRFPETIQAAKDSSVKLECFALGNPVPDISWRRLDGSPLPGKVKYSKSQAILEIPN 286
Query: 297 VTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGE 356
+ G Y C A+ R R A+G+L+ AP E+ Q Q+ ++ C+A G+
Sbjct: 287 FQQEDEGFYECIASN--LRGRNLAKGQLIFYAPPEWEQKIQNTHLSIYDNLLWECKASGK 344
Query: 357 PPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLT 416
P P TWLKNG+ L P R++ N TL I+ + D +YQC AEN A+A L
Sbjct: 345 PNPWYTWLKNGERLNP--EERIQIENGTLIITMLNVSDSGVYQCAAENKYQIIYANAELR 402
Query: 417 VL 418
VL
Sbjct: 403 VL 404
Score = 142 bits (359), Expect = 1e-33
Identities = 154/591 (26%), Positives = 234/591 (39%), Gaps = 44/591 (7%)
Query: 48 PSDDVAVPGQPIVLDCRVEGTPPVRITWRK-NGVELPESTHSTLLANGSLMIRHFRLEPG 106
P A + L+C G P I+WR+ +G LP + + L I +F+ E
Sbjct: 234 PETIQAAKDSSVKLECFALGNPVPDISWRRLDGSPLPGKVKYSK-SQAILEIPNFQQE-- 290
Query: 107 GSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGLP 166
DEG YEC+A N G +++ I A ++ Q T ++C+ G P
Sbjct: 291 ----DEGFYECIASNLRGRNLAKGQLIFYAP-PEWEQKIQNTHLSIYDNLLWECKASGKP 345
Query: 167 KPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLT 226
P TW KN ++ E + G L IT L D G++ C A N I I A L
Sbjct: 346 NPWYTWLKNGERLNP--EERIQIENGTLIITMLNVSDSGVYQCAAENKYQI-IYANAELR 402
Query: 227 VSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEGIQV 286
V S K P + + V V+ C PR +SW R + I +
Sbjct: 403 VLASAPDFSKSPV----KKKSFVQVGGDIVIGCKPNAFPRAAISWKRGTETLRQSKRIFL 458
Query: 287 LGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTT 346
L G+L I ++T +G Y C A + T G L+V+ P + G +
Sbjct: 459 LEDGSLKIYNITRSDAGSYTCIATNQFGTAKNT--GSLIVKERTVITVPPSKMDVTVGES 516
Query: 347 AMFTCQAQGEPPPHVT--WLKNGQVL----GPGGHVRLKNNN-STLTISGIGPEDEAIYQ 399
+ CQ +P V W NG V+ G R+ + L I I Y
Sbjct: 517 IVLPCQVSHDPSIEVVFVWFFNGDVIDLKKGVAHFERIGGESVGDLMIRNIQLHHSGKYL 576
Query: 400 CVAENSAGSSQASARLTVLWAEGLPGPPRNVRAVSVSSTEVRVSWSEPLANTKEIIGYVL 459
C + + S A A + V G PGPP +V+ +SST ++SW N I + +
Sbjct: 577 CTVQTTLESLSAVADIIV---RGPPGPPEDVQVEDISSTTSQLSWRAGPDNNSPIQIFTI 633
Query: 460 HIRKAADPPELEYQ------EAVSKSTFQHLVSDLEPSTAYSFYIKAYTPRGASSASVPT 513
R P + +Q E ++ T+ V L P Y F + A G S P+
Sbjct: 634 QTRT---PFSVGWQAVATVPEILNGKTYNATVVGLSPWVEYEFRVVAGNSIGIGEPSEPS 690
Query: 514 -LASTLGEAPAPPPLSVRVLGSSSLQLL--WEPWPRLAQHEGGFK--LFYRPASKTSFTG 568
L T P P+++ G S +L+ WE P Q+ GF + +RP T+++
Sbjct: 691 ELLRTKASVPVVAPVNIHGGGGSRSELVITWESIPEELQNGEGFGYIIMFRPVGSTTWSK 750
Query: 569 PILLPGTVSS--YNLSQLDPTAVYEVKLLAYNQHGDGNATVRFVSLRGASE 617
+ S Y + P + +EVK+ YN G+G+ + + G E
Sbjct: 751 EKVSSVESSRFVYRNESIIPLSPFEVKVGVYNNEGEGSLSTVTIVYSGEDE 801
Score = 132 bits (332), Expect = 1e-30
Identities = 142/581 (24%), Positives = 246/581 (42%), Gaps = 63/581 (10%)
Query: 59 IVLDCRVEGTPPVRITWRKNGVEL-PESTHSTLLANGSLMIRHFRLEPGGSPSDEGDYEC 117
++ +C+ G P TW KNG L PE + NG+L+I + SD G Y+C
Sbjct: 335 LLWECKASGKPNPWYTWLKNGERLNPEERIQ--IENGTLIITMLNV------SDSGVYQC 386
Query: 118 VAQNRFGLVVSRKARIQAATMSDFHVHP--QATVGEEGGVARFQCQIHGLPKPLITWEKN 175
A+N++ ++ + A+ DF P + + + GG C+ + P+ I+W++
Sbjct: 387 AAENKYQIIYANAELRVLASAPDFSKSPVKKKSFVQVGGDIVIGCKPNAFPRAAISWKRG 446
Query: 176 RVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLTVSGSGSGAY 235
+ ++R LL G L+I + D G + C+A+N T +GS
Sbjct: 447 TETL-RQSKRIFLLEDGSLKIYNITRSDAGSYTCIATNQFG---------TAKNTGSLIV 496
Query: 236 KEPAIL-VGPENLTLTVHQTAVLECVATGNPR-PIVSWSRLDGRPI----GVEGIQVLG- 288
KE ++ V P + +TV ++ VL C + +P +V +G I GV + +G
Sbjct: 497 KERTVITVPPSKMDVTVGESIVLPCQVSHDPSIEVVFVWFFNGDVIDLKKGVAHFERIGG 556
Query: 289 --TGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTT 346
G+L+I ++ + HSG Y+C T +A ++V+ P + Q + + TT
Sbjct: 557 ESVGDLMIRNIQLHHSGKYLCTVQT--TLESLSAVADIIVRGPPGPPEDVQ-VEDISSTT 613
Query: 347 AMFTCQA-------------QGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPE 393
+ + +A Q P V W Q + + L T+ G+ P
Sbjct: 614 SQLSWRAGPDNNSPIQIFTIQTRTPFSVGW----QAVATVPEI-LNGKTYNATVVGLSPW 668
Query: 394 DEAIYQCVAENSAGSSQASARLTVLWAEGLPG--PPRNVRAVSVSSTEVRVSWS---EPL 448
E ++ VA NS G + S +L + P N+ S +E+ ++W E L
Sbjct: 669 VEYEFRVVAGNSIGIGEPSEPSELLRTKASVPVVAPVNIHGGGGSRSELVITWESIPEEL 728
Query: 449 ANTKEIIGYVLHIRKAADPP-ELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKAYTPRGAS 507
N E GY++ R E +V S F + + P + + + Y G
Sbjct: 729 QNG-EGFGYIIMFRPVGSTTWSKEKVSSVESSRFVYRNESIIPLSPFEVKVGVYNNEGEG 787
Query: 508 SASVPTLASTLGEAP--APPPLSVRVLGSSSLQLLWEP--WPRLAQHEGGFK-LFYRPAS 562
S S T+ + + P AP S++ +S +++ W W R G++ L++ S
Sbjct: 788 SLSTVTIVYSGEDEPQLAPRGTSLQSFSASEMEVSWNAIAWNRNTGRVLGYEVLYWTDDS 847
Query: 563 KTSFTGPILLPGTVSSYNLSQLDPTAVYEVKLLAYNQHGDG 603
K S G I + G V++ N++ L +Y + AYN G G
Sbjct: 848 KESMIGKIRVSGNVTTKNITGLKANTIYFASVRAYNTAGTG 888
Score = 68.6 bits (166), Expect = 2e-11
Identities = 140/605 (23%), Positives = 220/605 (36%), Gaps = 70/605 (11%)
Query: 56 GQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRLEPGGSPSDEGDY 115
G IV+ C+ P I+W++ L +S LL +GSL I + + SD G Y
Sbjct: 424 GGDIVIGCKPNAFPRAAISWKRGTETLRQSKRIFLLEDGSLKIYNI------TRSDAGSY 477
Query: 116 ECVAQNRFGLVVSRKARIQAATMSDFHVHPQ---ATVGEEGGVARFQCQIHGLP--KPLI 170
C+A N+FG + + I + V P TVGE CQ+ P + +
Sbjct: 478 TCIATNQFGTAKNTGSLI-VKERTVITVPPSKMDVTVGES---IVLPCQVSHDPSIEVVF 533
Query: 171 TWEKNRVPIDTDN-----ERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARL 225
W N ID ER G L I ++ G + C +S A +
Sbjct: 534 VWFFNGDVIDLKKGVAHFERIGGESVGDLMIRNIQLHHSGKYLCTVQTTLE-SLSAVADI 592
Query: 226 TVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEGIQ 285
V G P V E+++ T Q + N PI ++ P V G Q
Sbjct: 593 IVRGPPG-----PPEDVQVEDISSTTSQLSWR--AGPDNNSPIQIFTIQTRTPFSV-GWQ 644
Query: 286 VLGTGNLIISDVTVQHSGV----------YVCAANRPGTRVRRTAQGRLVVQAPAEFVQH 335
+ T I++ T + V V A N G L +A V
Sbjct: 645 AVATVPEILNGKTYNATVVGLSPWVEYEFRVVAGNSIGIGEPSEPSELLRTKASVPVVA- 703
Query: 336 PQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLG-------PGGHVRLKNNNSTLTIS 388
P +I G+ + + P L+NG+ G G K S++ S
Sbjct: 704 PVNIHGGGGSRSELVITWESIPEE----LQNGEGFGYIIMFRPVGSTTWSKEKVSSVESS 759
Query: 389 GIGPEDEAIY-------QCVAENSAGSSQASARLTVLWAEGLPG-PPRNVRAVSVSSTEV 440
+E+I + N+ G S V E P PR S S++E+
Sbjct: 760 RFVYRNESIIPLSPFEVKVGVYNNEGEGSLSTVTIVYSGEDEPQLAPRGTSLQSFSASEM 819
Query: 441 RVSWSEPL--ANTKEIIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPSTAYSFYI 498
VSW+ NT ++GY + + + VS + ++ L+ +T Y +
Sbjct: 820 EVSWNAIAWNRNTGRVLGYEVLYWTDDSKESMIGKIRVSGNVTTKNITGLKANTIYFASV 879
Query: 499 KAYTPRGASSASVPTLASTLGEAPAPPPLSVR-VLGSSSLQLLWEPWPRLAQHEG--GFK 555
+AY G +S P +T P+ PP ++ L +S L L WE + G+K
Sbjct: 880 RAYNTAGTGPSSPPVNVTTKKSPPSQPPANIAWKLTNSKLCLNWEHVKTMENESEVLGYK 939
Query: 556 LFYRP--ASKTSFTGPILLPGTVSSYNLSQLDPTAVYEVKLLAYNQHGDGNATVRFVSLR 613
+ YR SKT IL S+ L + + E++ ++ G + +R +
Sbjct: 940 ILYRQNRQSKTH----ILETNNTSAELLVPFEEDYLIEIRTVSDGGDGSSSEEIRIPKMS 995
Query: 614 GASER 618
S R
Sbjct: 996 SLSSR 1000
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 163 bits (412), Expect = 7e-40
Identities = 129/389 (33%), Positives = 173/389 (44%), Gaps = 33/389 (8%)
Query: 48 PSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPES-----THSTLLANGSLMIRHFR 102
PSD + G+P L+C+ EG P I W K G + +H LL +GSL R
Sbjct: 35 PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFF--LR 92
Query: 103 LEPGG-SPSDEGDYECVAQNRFGLVVSRKARIQAATM-SDFHVHPQATVGEEGGVARFQC 160
+ G S DEG Y CVA+N G VS A ++ A + DF +P + G A +C
Sbjct: 93 IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMEC 152
Query: 161 QI-HGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRI 219
Q G P+P I+W+K+ P+D +ER T+ G L IT R D G + CV +N+ R
Sbjct: 153 QPPRGHPEPTISWKKDGSPLDDKDERITIRG-GKLMITYTRKSDAGKYVCVGTNMVGERE 211
Query: 220 SHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPI 279
S A LTV + P+ + P NL +TV +A +C A G+P P V W + DG +
Sbjct: 212 SEVAELTV-------LERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE-L 263
Query: 280 GVEGIQVLGTGNLIISDVTVQHSGVYVCAA-NRPGTRVRRTAQGRLVVQA---PAEFVQH 335
++ L I VT G Y C A N G + A L VQ P FV
Sbjct: 264 PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVG---KAEASATLTVQVGSEPPHFVVK 320
Query: 336 PQSISRPAGTTAMFTCQAQGEPPPHVTWLKNG------QVLGPGGHVRLK-NNNSTLTIS 388
P+ G T F C+A G P P + W + G P R + LTI+
Sbjct: 321 PRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTIT 380
Query: 389 GIGPEDEAIYQCVAENSAGSSQASARLTV 417
+ D Y C N AGS A L V
Sbjct: 381 NVQRSDVGYYICQTLNVAGSIITKAYLEV 409
Score = 150 bits (379), Expect = 5e-36
Identities = 144/579 (24%), Positives = 226/579 (39%), Gaps = 67/579 (11%)
Query: 34 EGLGHSAELAFAV-------EPSDDVAVPGQPIVLDCRV-EGTPPVRITWRKNGVELPES 85
E + H+A L A+ PSD + G+P V++C+ G P I+W+K+G L +
Sbjct: 116 EAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDK 175
Query: 86 THSTLLANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHP 145
+ G LMI + R SD G Y CV N G S A + F P
Sbjct: 176 DERITIRGGKLMITYTR------KSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRP 229
Query: 146 QATVGEEGGVARFQCQIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGG 205
A F+C+ G P P + W K+ + RY + L+I + A D G
Sbjct: 230 SNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP--KSRYEIRDDHTLKIRKVTAGDMG 287
Query: 206 IFHCVASNIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNP 265
+ CVA N+ + A LTV + P +V P + + + +T +C ATGNP
Sbjct: 288 SYTCVAENMVG-KAEASATLTVQVGS----EPPHFVVKPRDQVVALGRTVTFQCEATGNP 342
Query: 266 RPIVSWSRLDGR--------PIGVEGIQVLGTGNLIISDVTVQHSGVYVCAA-NRPGTRV 316
+P + W R + P V TG+L I++V G Y+C N G+ +
Sbjct: 343 QPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSII 402
Query: 317 RRT---AQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPG 373
+ + + P Q P + + T + +C A G P P + W K+G ++
Sbjct: 403 TKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQ 462
Query: 374 GHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTV------------LWAE 421
+ N L I D Y C+A +G + SA + V
Sbjct: 463 DSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPN 522
Query: 422 GLPGPPRNVRAVSVSSTEVRVSWSEPLANTKEIIGYVLHIRKAADPPELEYQEAVSKSTF 481
+P P VS V +SW L + Y++ A + A + T
Sbjct: 523 LIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQ-TVAENVKTE 581
Query: 482 QHLVSDLEPSTAYSFYIKAYTPRGASSAS-----------VPT--------LASTLGEAP 522
+ L+P+ Y F ++A G S S +PT + LG A
Sbjct: 582 TSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAV 641
Query: 523 APPPLSVRVLGSSSLQLLWEPWPRLAQHEGGFKLFYRPA 561
+ VL SSS+++ W + +Q+ G+K+ YRP+
Sbjct: 642 LHLH-NPTVLSSSSIEVHWTV-DQQSQYIQGYKILYRPS 678
Score = 120 bits (302), Expect = 4e-27
Identities = 93/287 (32%), Positives = 136/287 (47%), Gaps = 25/287 (8%)
Query: 144 HPQATVGEEGGVARFQCQIHGLPKPLITWEKNRVPIDTDNE----RYTLLPKGVL----Q 195
HP + +G A C+ G P P I W K ++TD + LLP G L
Sbjct: 34 HPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRI 93
Query: 196 ITGLRAE-DGGIFHCVASNIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQT 254
+ G ++ D G++ CVA N +SH A L V A P ++ + V +
Sbjct: 94 VHGRKSRPDEGVYVCVARNYLGEAVSHNASLEV------AILRDDFRQNPSDVMVAVGEP 147
Query: 255 AVLEC-VATGNPRPIVSWSRLDGRPIG--VEGIQVLGTGNLIISDVTVQHSGVYVC-AAN 310
AV+EC G+P P +SW + DG P+ E I + G G L+I+ +G YVC N
Sbjct: 148 AVMECQPPRGHPEPTISWKK-DGSPLDDKDERITIRG-GKLMITYTRKSDAGKYVCVGTN 205
Query: 311 RPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVL 370
G R A+ L V FV+ P +++ +A F C+A+G+P P V W K+ L
Sbjct: 206 MVGERESEVAE--LTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL 263
Query: 371 GPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTV 417
P +++++ TL I + D Y CVAEN G ++ASA LTV
Sbjct: 264 -PKSRYEIRDDH-TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 308
Score = 107 bits (267), Expect = 4e-23
Identities = 161/682 (23%), Positives = 260/682 (38%), Gaps = 77/682 (11%)
Query: 43 AFAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFR 102
+F PS+ C G P + WRK+ ELP+S + + + +L IR
Sbjct: 224 SFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYE-IRDDHTLKIRKV- 281
Query: 103 LEPGGSPSDEGDYECVAQNRFGLV-VSRKARIQAATMSD-FHVHPQATVGEEGGVARFQC 160
+ D G Y CVA+N G S +Q + F V P+ V G FQC
Sbjct: 282 -----TAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQC 336
Query: 161 QIHGLPKPLITWEKN-------RVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASN 213
+ G P+P I W + + R+++ G L IT ++ D G + C N
Sbjct: 337 EATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLN 396
Query: 214 IASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSR 273
+A I+ A L V+ + P I GP N T+ V T VL CVATG+P P + W R
Sbjct: 397 VAGSIITK-AYLEVTDVIADR-PPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILW-R 453
Query: 274 LDGRPIGVEG--IQVLGTGNLIISDVTVQHSGVYVCAANRP---------------GTRV 316
DG + + I+ L G L I + +G Y C A+ P G V
Sbjct: 454 KDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPV 513
Query: 317 R--RTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGG 374
+ R L+ AP++ +SR T + G P G
Sbjct: 514 QPPRPTDPNLIPSAPSK--PEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSW 571
Query: 375 HVRLKN-NNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAEGLPGPPRNVRAV 433
+N T I G+ P ++ A N+ G S S + + + + V
Sbjct: 572 QTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHK 631
Query: 434 SV-----------------SSTEVRVSWSEPLANTKEIIGY-VLHIRKAADPPELEYQ-- 473
V SS+ + V W+ ++ I GY +L+ A+ E ++
Sbjct: 632 QVQRELGNAVLHLHNPTVLSSSSIEVHWTVD-QQSQYIQGYKILYRPSGANHGESDWLVF 690
Query: 474 EAVSKSTFQHLVSDLEPSTAYSFYIKAYTPRGASSASVPTLASTLGEAPAPPPLSVRVL- 532
E + + ++ DL Y + + + S A TL EAP+ PP V V
Sbjct: 691 EVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSK 750
Query: 533 ---GSSSLQLLWEPWPRLAQHEGGFKLFYRP---ASKTSFTGPILLPGTVSSYNLSQLDP 586
+++ + W+P P Q+ G Y+ ++T + + G+ S + L P
Sbjct: 751 NDGNGTAILVSWQPPPEDTQN--GMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVP 808
Query: 587 TAVYEVKLLAYNQHGDG-NATVRFVSLRGASERTALSPPCDCR-KEEAANQTSTTGIVIG 644
Y V++ A G G + +F+ L + +SP ++ ++ + G
Sbjct: 809 GIRYSVEVAASTGAGSGVKSEPQFIQL--DAHGNPVSPEDQVSLAQQISDVVKQPAFIAG 866
Query: 645 IHIGVTCIIFCVLFLLFGQRGR 666
IG C I ++F ++ R R
Sbjct: 867 --IGAACWIILMVFSIWLYRHR 886
Score = 64.3 bits (155), Expect = 4e-10
Identities = 62/229 (27%), Positives = 93/229 (40%), Gaps = 20/229 (8%)
Query: 230 SGSGAYKE---PAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVE---- 282
SGS +E P I+ P +L ++ + A L C A G P P + W + G + +
Sbjct: 18 SGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYK-GGERVETDKDDP 76
Query: 283 --GIQVLGTGNLIISDV-----TVQHSGVYVCAA-NRPGTRVRRTAQGRLVVQAPAEFVQ 334
+L +G+L + + GVYVC A N G V A + + +F Q
Sbjct: 77 RSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD-DFRQ 135
Query: 335 HPQSISRPAGTTAMFTCQ-AQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPE 393
+P + G A+ CQ +G P P ++W K+G L R+ L I+
Sbjct: 136 NPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDE-RITIRGGKLMITYTRKS 194
Query: 394 DEAIYQCVAENSAGSSQAS-ARLTVLWAEGLPGPPRNVRAVSVSSTEVR 441
D Y CV N G ++ A LTVL P N+ S E +
Sbjct: 195 DAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFK 243
>gi|224994171 roundabout 1 isoform c [Homo sapiens]
Length = 1606
Score = 163 bits (412), Expect = 7e-40
Identities = 129/389 (33%), Positives = 173/389 (44%), Gaps = 33/389 (8%)
Query: 48 PSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPES-----THSTLLANGSLMIRHFR 102
PSD + G+P L+C+ EG P I W K G + +H LL +GSL R
Sbjct: 35 PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFF--LR 92
Query: 103 LEPGG-SPSDEGDYECVAQNRFGLVVSRKARIQAATM-SDFHVHPQATVGEEGGVARFQC 160
+ G S DEG Y CVA+N G VS A ++ A + DF +P + G A +C
Sbjct: 93 IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMEC 152
Query: 161 QI-HGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRI 219
Q G P+P I+W+K+ P+D +ER T+ G L IT R D G + CV +N+ R
Sbjct: 153 QPPRGHPEPTISWKKDGSPLDDKDERITIRG-GKLMITYTRKSDAGKYVCVGTNMVGERE 211
Query: 220 SHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPI 279
S A LTV + P+ + P NL +TV +A +C A G+P P V W + DG +
Sbjct: 212 SEVAELTV-------LERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE-L 263
Query: 280 GVEGIQVLGTGNLIISDVTVQHSGVYVCAA-NRPGTRVRRTAQGRLVVQA---PAEFVQH 335
++ L I VT G Y C A N G + A L VQ P FV
Sbjct: 264 PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVG---KAEASATLTVQVGSEPPHFVVK 320
Query: 336 PQSISRPAGTTAMFTCQAQGEPPPHVTWLKNG------QVLGPGGHVRLK-NNNSTLTIS 388
P+ G T F C+A G P P + W + G P R + LTI+
Sbjct: 321 PRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTIT 380
Query: 389 GIGPEDEAIYQCVAENSAGSSQASARLTV 417
+ D Y C N AGS A L V
Sbjct: 381 NVQRSDVGYYICQTLNVAGSIITKAYLEV 409
Score = 150 bits (379), Expect = 5e-36
Identities = 144/579 (24%), Positives = 226/579 (39%), Gaps = 67/579 (11%)
Query: 34 EGLGHSAELAFAV-------EPSDDVAVPGQPIVLDCRV-EGTPPVRITWRKNGVELPES 85
E + H+A L A+ PSD + G+P V++C+ G P I+W+K+G L +
Sbjct: 116 EAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDK 175
Query: 86 THSTLLANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHP 145
+ G LMI + R SD G Y CV N G S A + F P
Sbjct: 176 DERITIRGGKLMITYTR------KSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRP 229
Query: 146 QATVGEEGGVARFQCQIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGG 205
A F+C+ G P P + W K+ + RY + L+I + A D G
Sbjct: 230 SNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP--KSRYEIRDDHTLKIRKVTAGDMG 287
Query: 206 IFHCVASNIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNP 265
+ CVA N+ + A LTV + P +V P + + + +T +C ATGNP
Sbjct: 288 SYTCVAENMVG-KAEASATLTVQVGS----EPPHFVVKPRDQVVALGRTVTFQCEATGNP 342
Query: 266 RPIVSWSRLDGR--------PIGVEGIQVLGTGNLIISDVTVQHSGVYVCAA-NRPGTRV 316
+P + W R + P V TG+L I++V G Y+C N G+ +
Sbjct: 343 QPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSII 402
Query: 317 RRT---AQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPG 373
+ + + P Q P + + T + +C A G P P + W K+G ++
Sbjct: 403 TKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQ 462
Query: 374 GHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTV------------LWAE 421
+ N L I D Y C+A +G + SA + V
Sbjct: 463 DSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPN 522
Query: 422 GLPGPPRNVRAVSVSSTEVRVSWSEPLANTKEIIGYVLHIRKAADPPELEYQEAVSKSTF 481
+P P VS V +SW L + Y++ A + A + T
Sbjct: 523 LIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQ-TVAENVKTE 581
Query: 482 QHLVSDLEPSTAYSFYIKAYTPRGASSAS-----------VPT--------LASTLGEAP 522
+ L+P+ Y F ++A G S S +PT + LG A
Sbjct: 582 TSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAV 641
Query: 523 APPPLSVRVLGSSSLQLLWEPWPRLAQHEGGFKLFYRPA 561
+ VL SSS+++ W + +Q+ G+K+ YRP+
Sbjct: 642 LHLH-NPTVLSSSSIEVHWTV-DQQSQYIQGYKILYRPS 678
Score = 120 bits (302), Expect = 4e-27
Identities = 93/287 (32%), Positives = 136/287 (47%), Gaps = 25/287 (8%)
Query: 144 HPQATVGEEGGVARFQCQIHGLPKPLITWEKNRVPIDTDNE----RYTLLPKGVL----Q 195
HP + +G A C+ G P P I W K ++TD + LLP G L
Sbjct: 34 HPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRI 93
Query: 196 ITGLRAE-DGGIFHCVASNIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQT 254
+ G ++ D G++ CVA N +SH A L V A P ++ + V +
Sbjct: 94 VHGRKSRPDEGVYVCVARNYLGEAVSHNASLEV------AILRDDFRQNPSDVMVAVGEP 147
Query: 255 AVLEC-VATGNPRPIVSWSRLDGRPIG--VEGIQVLGTGNLIISDVTVQHSGVYVC-AAN 310
AV+EC G+P P +SW + DG P+ E I + G G L+I+ +G YVC N
Sbjct: 148 AVMECQPPRGHPEPTISWKK-DGSPLDDKDERITIRG-GKLMITYTRKSDAGKYVCVGTN 205
Query: 311 RPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVL 370
G R A+ L V FV+ P +++ +A F C+A+G+P P V W K+ L
Sbjct: 206 MVGERESEVAE--LTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL 263
Query: 371 GPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTV 417
P +++++ TL I + D Y CVAEN G ++ASA LTV
Sbjct: 264 -PKSRYEIRDDH-TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 308
Score = 107 bits (267), Expect = 4e-23
Identities = 161/682 (23%), Positives = 260/682 (38%), Gaps = 77/682 (11%)
Query: 43 AFAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFR 102
+F PS+ C G P + WRK+ ELP+S + + + +L IR
Sbjct: 224 SFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYE-IRDDHTLKIRKV- 281
Query: 103 LEPGGSPSDEGDYECVAQNRFGLV-VSRKARIQAATMSD-FHVHPQATVGEEGGVARFQC 160
+ D G Y CVA+N G S +Q + F V P+ V G FQC
Sbjct: 282 -----TAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQC 336
Query: 161 QIHGLPKPLITWEKN-------RVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASN 213
+ G P+P I W + + R+++ G L IT ++ D G + C N
Sbjct: 337 EATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLN 396
Query: 214 IASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSR 273
+A I+ A L V+ + P I GP N T+ V T VL CVATG+P P + W R
Sbjct: 397 VAGSIITK-AYLEVTDVIADR-PPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILW-R 453
Query: 274 LDGRPIGVEG--IQVLGTGNLIISDVTVQHSGVYVCAANRP---------------GTRV 316
DG + + I+ L G L I + +G Y C A+ P G V
Sbjct: 454 KDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPV 513
Query: 317 R--RTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGG 374
+ R L+ AP++ +SR T + G P G
Sbjct: 514 QPPRPTDPNLIPSAPSK--PEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSW 571
Query: 375 HVRLKN-NNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAEGLPGPPRNVRAV 433
+N T I G+ P ++ A N+ G S S + + + + V
Sbjct: 572 QTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHK 631
Query: 434 SV-----------------SSTEVRVSWSEPLANTKEIIGY-VLHIRKAADPPELEYQ-- 473
V SS+ + V W+ ++ I GY +L+ A+ E ++
Sbjct: 632 QVQRELGNAVLHLHNPTVLSSSSIEVHWTVD-QQSQYIQGYKILYRPSGANHGESDWLVF 690
Query: 474 EAVSKSTFQHLVSDLEPSTAYSFYIKAYTPRGASSASVPTLASTLGEAPAPPPLSVRVL- 532
E + + ++ DL Y + + + S A TL EAP+ PP V V
Sbjct: 691 EVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSK 750
Query: 533 ---GSSSLQLLWEPWPRLAQHEGGFKLFYRP---ASKTSFTGPILLPGTVSSYNLSQLDP 586
+++ + W+P P Q+ G Y+ ++T + + G+ S + L P
Sbjct: 751 NDGNGTAILVSWQPPPEDTQN--GMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVP 808
Query: 587 TAVYEVKLLAYNQHGDG-NATVRFVSLRGASERTALSPPCDCR-KEEAANQTSTTGIVIG 644
Y V++ A G G + +F+ L + +SP ++ ++ + G
Sbjct: 809 GIRYSVEVAASTGAGSGVKSEPQFIQL--DAHGNPVSPEDQVSLAQQISDVVKQPAFIAG 866
Query: 645 IHIGVTCIIFCVLFLLFGQRGR 666
IG C I ++F ++ R R
Sbjct: 867 --IGAACWIILMVFSIWLYRHR 886
Score = 64.3 bits (155), Expect = 4e-10
Identities = 62/229 (27%), Positives = 93/229 (40%), Gaps = 20/229 (8%)
Query: 230 SGSGAYKE---PAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVE---- 282
SGS +E P I+ P +L ++ + A L C A G P P + W + G + +
Sbjct: 18 SGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYK-GGERVETDKDDP 76
Query: 283 --GIQVLGTGNLIISDV-----TVQHSGVYVCAA-NRPGTRVRRTAQGRLVVQAPAEFVQ 334
+L +G+L + + GVYVC A N G V A + + +F Q
Sbjct: 77 RSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD-DFRQ 135
Query: 335 HPQSISRPAGTTAMFTCQ-AQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPE 393
+P + G A+ CQ +G P P ++W K+G L R+ L I+
Sbjct: 136 NPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDE-RITIRGGKLMITYTRKS 194
Query: 394 DEAIYQCVAENSAGSSQAS-ARLTVLWAEGLPGPPRNVRAVSVSSTEVR 441
D Y CV N G ++ A LTVL P N+ S E +
Sbjct: 195 DAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFK 243
>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
sapiens]
Length = 1562
Score = 163 bits (412), Expect = 7e-40
Identities = 129/389 (33%), Positives = 173/389 (44%), Gaps = 33/389 (8%)
Query: 48 PSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPES-----THSTLLANGSLMIRHFR 102
PSD + G+P L+C+ EG P I W K G + +H LL +GSL R
Sbjct: 35 PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFF--LR 92
Query: 103 LEPGG-SPSDEGDYECVAQNRFGLVVSRKARIQAATM-SDFHVHPQATVGEEGGVARFQC 160
+ G S DEG Y CVA+N G VS A ++ A + DF +P + G A +C
Sbjct: 93 IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMEC 152
Query: 161 QI-HGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRI 219
Q G P+P I+W+K+ P+D +ER T+ G L IT R D G + CV +N+ R
Sbjct: 153 QPPRGHPEPTISWKKDGSPLDDKDERITIRG-GKLMITYTRKSDAGKYVCVGTNMVGERE 211
Query: 220 SHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPI 279
S A LTV + P+ + P NL +TV +A +C A G+P P V W + DG +
Sbjct: 212 SEVAELTV-------LERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE-L 263
Query: 280 GVEGIQVLGTGNLIISDVTVQHSGVYVCAA-NRPGTRVRRTAQGRLVVQA---PAEFVQH 335
++ L I VT G Y C A N G + A L VQ P FV
Sbjct: 264 PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVG---KAEASATLTVQVGSEPPHFVVK 320
Query: 336 PQSISRPAGTTAMFTCQAQGEPPPHVTWLKNG------QVLGPGGHVRLK-NNNSTLTIS 388
P+ G T F C+A G P P + W + G P R + LTI+
Sbjct: 321 PRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTIT 380
Query: 389 GIGPEDEAIYQCVAENSAGSSQASARLTV 417
+ D Y C N AGS A L V
Sbjct: 381 NVQRSDVGYYICQTLNVAGSIITKAYLEV 409
Score = 150 bits (379), Expect = 5e-36
Identities = 144/579 (24%), Positives = 226/579 (39%), Gaps = 67/579 (11%)
Query: 34 EGLGHSAELAFAV-------EPSDDVAVPGQPIVLDCRV-EGTPPVRITWRKNGVELPES 85
E + H+A L A+ PSD + G+P V++C+ G P I+W+K+G L +
Sbjct: 116 EAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDK 175
Query: 86 THSTLLANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHP 145
+ G LMI + R SD G Y CV N G S A + F P
Sbjct: 176 DERITIRGGKLMITYTR------KSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRP 229
Query: 146 QATVGEEGGVARFQCQIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGG 205
A F+C+ G P P + W K+ + RY + L+I + A D G
Sbjct: 230 SNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP--KSRYEIRDDHTLKIRKVTAGDMG 287
Query: 206 IFHCVASNIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNP 265
+ CVA N+ + A LTV + P +V P + + + +T +C ATGNP
Sbjct: 288 SYTCVAENMVG-KAEASATLTVQVGS----EPPHFVVKPRDQVVALGRTVTFQCEATGNP 342
Query: 266 RPIVSWSRLDGR--------PIGVEGIQVLGTGNLIISDVTVQHSGVYVCAA-NRPGTRV 316
+P + W R + P V TG+L I++V G Y+C N G+ +
Sbjct: 343 QPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSII 402
Query: 317 RRT---AQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPG 373
+ + + P Q P + + T + +C A G P P + W K+G ++
Sbjct: 403 TKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQ 462
Query: 374 GHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTV------------LWAE 421
+ N L I D Y C+A +G + SA + V
Sbjct: 463 DSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPN 522
Query: 422 GLPGPPRNVRAVSVSSTEVRVSWSEPLANTKEIIGYVLHIRKAADPPELEYQEAVSKSTF 481
+P P VS V +SW L + Y++ A + A + T
Sbjct: 523 LIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQ-TVAENVKTE 581
Query: 482 QHLVSDLEPSTAYSFYIKAYTPRGASSAS-----------VPT--------LASTLGEAP 522
+ L+P+ Y F ++A G S S +PT + LG A
Sbjct: 582 TSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAV 641
Query: 523 APPPLSVRVLGSSSLQLLWEPWPRLAQHEGGFKLFYRPA 561
+ VL SSS+++ W + +Q+ G+K+ YRP+
Sbjct: 642 LHLH-NPTVLSSSSIEVHWTV-DQQSQYIQGYKILYRPS 678
Score = 120 bits (302), Expect = 4e-27
Identities = 93/287 (32%), Positives = 136/287 (47%), Gaps = 25/287 (8%)
Query: 144 HPQATVGEEGGVARFQCQIHGLPKPLITWEKNRVPIDTDNE----RYTLLPKGVL----Q 195
HP + +G A C+ G P P I W K ++TD + LLP G L
Sbjct: 34 HPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRI 93
Query: 196 ITGLRAE-DGGIFHCVASNIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQT 254
+ G ++ D G++ CVA N +SH A L V A P ++ + V +
Sbjct: 94 VHGRKSRPDEGVYVCVARNYLGEAVSHNASLEV------AILRDDFRQNPSDVMVAVGEP 147
Query: 255 AVLEC-VATGNPRPIVSWSRLDGRPIG--VEGIQVLGTGNLIISDVTVQHSGVYVC-AAN 310
AV+EC G+P P +SW + DG P+ E I + G G L+I+ +G YVC N
Sbjct: 148 AVMECQPPRGHPEPTISWKK-DGSPLDDKDERITIRG-GKLMITYTRKSDAGKYVCVGTN 205
Query: 311 RPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVL 370
G R A+ L V FV+ P +++ +A F C+A+G+P P V W K+ L
Sbjct: 206 MVGERESEVAE--LTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL 263
Query: 371 GPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTV 417
P +++++ TL I + D Y CVAEN G ++ASA LTV
Sbjct: 264 -PKSRYEIRDDH-TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 308
Score = 107 bits (267), Expect = 4e-23
Identities = 161/682 (23%), Positives = 260/682 (38%), Gaps = 77/682 (11%)
Query: 43 AFAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFR 102
+F PS+ C G P + WRK+ ELP+S + + + +L IR
Sbjct: 224 SFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYE-IRDDHTLKIRKV- 281
Query: 103 LEPGGSPSDEGDYECVAQNRFGLV-VSRKARIQAATMSD-FHVHPQATVGEEGGVARFQC 160
+ D G Y CVA+N G S +Q + F V P+ V G FQC
Sbjct: 282 -----TAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQC 336
Query: 161 QIHGLPKPLITWEKN-------RVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASN 213
+ G P+P I W + + R+++ G L IT ++ D G + C N
Sbjct: 337 EATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLN 396
Query: 214 IASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSR 273
+A I+ A L V+ + P I GP N T+ V T VL CVATG+P P + W R
Sbjct: 397 VAGSIITK-AYLEVTDVIADR-PPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILW-R 453
Query: 274 LDGRPIGVEG--IQVLGTGNLIISDVTVQHSGVYVCAANRP---------------GTRV 316
DG + + I+ L G L I + +G Y C A+ P G V
Sbjct: 454 KDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPV 513
Query: 317 R--RTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGG 374
+ R L+ AP++ +SR T + G P G
Sbjct: 514 QPPRPTDPNLIPSAPSK--PEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSW 571
Query: 375 HVRLKN-NNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAEGLPGPPRNVRAV 433
+N T I G+ P ++ A N+ G S S + + + + V
Sbjct: 572 QTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHK 631
Query: 434 SV-----------------SSTEVRVSWSEPLANTKEIIGY-VLHIRKAADPPELEYQ-- 473
V SS+ + V W+ ++ I GY +L+ A+ E ++
Sbjct: 632 QVQRELGNAVLHLHNPTVLSSSSIEVHWTVD-QQSQYIQGYKILYRPSGANHGESDWLVF 690
Query: 474 EAVSKSTFQHLVSDLEPSTAYSFYIKAYTPRGASSASVPTLASTLGEAPAPPPLSVRVL- 532
E + + ++ DL Y + + + S A TL EAP+ PP V V
Sbjct: 691 EVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSK 750
Query: 533 ---GSSSLQLLWEPWPRLAQHEGGFKLFYRP---ASKTSFTGPILLPGTVSSYNLSQLDP 586
+++ + W+P P Q+ G Y+ ++T + + G+ S + L P
Sbjct: 751 NDGNGTAILVSWQPPPEDTQN--GMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVP 808
Query: 587 TAVYEVKLLAYNQHGDG-NATVRFVSLRGASERTALSPPCDCR-KEEAANQTSTTGIVIG 644
Y V++ A G G + +F+ L + +SP ++ ++ + G
Sbjct: 809 GIRYSVEVAASTGAGSGVKSEPQFIQL--DAHGNPVSPEDQVSLAQQISDVVKQPAFIAG 866
Query: 645 IHIGVTCIIFCVLFLLFGQRGR 666
IG C I ++F ++ R R
Sbjct: 867 --IGAACWIILMVFSIWLYRHR 886
Score = 64.3 bits (155), Expect = 4e-10
Identities = 62/229 (27%), Positives = 93/229 (40%), Gaps = 20/229 (8%)
Query: 230 SGSGAYKE---PAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVE---- 282
SGS +E P I+ P +L ++ + A L C A G P P + W + G + +
Sbjct: 18 SGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYK-GGERVETDKDDP 76
Query: 283 --GIQVLGTGNLIISDV-----TVQHSGVYVCAA-NRPGTRVRRTAQGRLVVQAPAEFVQ 334
+L +G+L + + GVYVC A N G V A + + +F Q
Sbjct: 77 RSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD-DFRQ 135
Query: 335 HPQSISRPAGTTAMFTCQ-AQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPE 393
+P + G A+ CQ +G P P ++W K+G L R+ L I+
Sbjct: 136 NPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDE-RITIRGGKLMITYTRKS 194
Query: 394 DEAIYQCVAENSAGSSQAS-ARLTVLWAEGLPGPPRNVRAVSVSSTEVR 441
D Y CV N G ++ A LTVL P N+ S E +
Sbjct: 195 DAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFK 243
>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
sapiens]
Length = 1615
Score = 163 bits (412), Expect = 7e-40
Identities = 129/389 (33%), Positives = 173/389 (44%), Gaps = 33/389 (8%)
Query: 48 PSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPES-----THSTLLANGSLMIRHFR 102
PSD + G+P L+C+ EG P I W K G + +H LL +GSL R
Sbjct: 35 PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFF--LR 92
Query: 103 LEPGG-SPSDEGDYECVAQNRFGLVVSRKARIQAATM-SDFHVHPQATVGEEGGVARFQC 160
+ G S DEG Y CVA+N G VS A ++ A + DF +P + G A +C
Sbjct: 93 IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMEC 152
Query: 161 QI-HGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRI 219
Q G P+P I+W+K+ P+D +ER T+ G L IT R D G + CV +N+ R
Sbjct: 153 QPPRGHPEPTISWKKDGSPLDDKDERITIRG-GKLMITYTRKSDAGKYVCVGTNMVGERE 211
Query: 220 SHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPI 279
S A LTV + P+ + P NL +TV +A +C A G+P P V W + DG +
Sbjct: 212 SEVAELTV-------LERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE-L 263
Query: 280 GVEGIQVLGTGNLIISDVTVQHSGVYVCAA-NRPGTRVRRTAQGRLVVQA---PAEFVQH 335
++ L I VT G Y C A N G + A L VQ P FV
Sbjct: 264 PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVG---KAEASATLTVQVGSEPPHFVVK 320
Query: 336 PQSISRPAGTTAMFTCQAQGEPPPHVTWLKNG------QVLGPGGHVRLK-NNNSTLTIS 388
P+ G T F C+A G P P + W + G P R + LTI+
Sbjct: 321 PRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTIT 380
Query: 389 GIGPEDEAIYQCVAENSAGSSQASARLTV 417
+ D Y C N AGS A L V
Sbjct: 381 NVQRSDVGYYICQTLNVAGSIITKAYLEV 409
Score = 150 bits (379), Expect = 5e-36
Identities = 144/579 (24%), Positives = 226/579 (39%), Gaps = 67/579 (11%)
Query: 34 EGLGHSAELAFAV-------EPSDDVAVPGQPIVLDCRV-EGTPPVRITWRKNGVELPES 85
E + H+A L A+ PSD + G+P V++C+ G P I+W+K+G L +
Sbjct: 116 EAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDK 175
Query: 86 THSTLLANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHP 145
+ G LMI + R SD G Y CV N G S A + F P
Sbjct: 176 DERITIRGGKLMITYTR------KSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRP 229
Query: 146 QATVGEEGGVARFQCQIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGG 205
A F+C+ G P P + W K+ + RY + L+I + A D G
Sbjct: 230 SNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP--KSRYEIRDDHTLKIRKVTAGDMG 287
Query: 206 IFHCVASNIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNP 265
+ CVA N+ + A LTV + P +V P + + + +T +C ATGNP
Sbjct: 288 SYTCVAENMVG-KAEASATLTVQVGS----EPPHFVVKPRDQVVALGRTVTFQCEATGNP 342
Query: 266 RPIVSWSRLDGR--------PIGVEGIQVLGTGNLIISDVTVQHSGVYVCAA-NRPGTRV 316
+P + W R + P V TG+L I++V G Y+C N G+ +
Sbjct: 343 QPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSII 402
Query: 317 RRT---AQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPG 373
+ + + P Q P + + T + +C A G P P + W K+G ++
Sbjct: 403 TKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQ 462
Query: 374 GHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTV------------LWAE 421
+ N L I D Y C+A +G + SA + V
Sbjct: 463 DSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPN 522
Query: 422 GLPGPPRNVRAVSVSSTEVRVSWSEPLANTKEIIGYVLHIRKAADPPELEYQEAVSKSTF 481
+P P VS V +SW L + Y++ A + A + T
Sbjct: 523 LIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQ-TVAENVKTE 581
Query: 482 QHLVSDLEPSTAYSFYIKAYTPRGASSAS-----------VPT--------LASTLGEAP 522
+ L+P+ Y F ++A G S S +PT + LG A
Sbjct: 582 TSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAV 641
Query: 523 APPPLSVRVLGSSSLQLLWEPWPRLAQHEGGFKLFYRPA 561
+ VL SSS+++ W + +Q+ G+K+ YRP+
Sbjct: 642 LHLH-NPTVLSSSSIEVHWTV-DQQSQYIQGYKILYRPS 678
Score = 120 bits (302), Expect = 4e-27
Identities = 93/287 (32%), Positives = 136/287 (47%), Gaps = 25/287 (8%)
Query: 144 HPQATVGEEGGVARFQCQIHGLPKPLITWEKNRVPIDTDNE----RYTLLPKGVL----Q 195
HP + +G A C+ G P P I W K ++TD + LLP G L
Sbjct: 34 HPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRI 93
Query: 196 ITGLRAE-DGGIFHCVASNIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQT 254
+ G ++ D G++ CVA N +SH A L V A P ++ + V +
Sbjct: 94 VHGRKSRPDEGVYVCVARNYLGEAVSHNASLEV------AILRDDFRQNPSDVMVAVGEP 147
Query: 255 AVLEC-VATGNPRPIVSWSRLDGRPIG--VEGIQVLGTGNLIISDVTVQHSGVYVC-AAN 310
AV+EC G+P P +SW + DG P+ E I + G G L+I+ +G YVC N
Sbjct: 148 AVMECQPPRGHPEPTISWKK-DGSPLDDKDERITIRG-GKLMITYTRKSDAGKYVCVGTN 205
Query: 311 RPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVL 370
G R A+ L V FV+ P +++ +A F C+A+G+P P V W K+ L
Sbjct: 206 MVGERESEVAE--LTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL 263
Query: 371 GPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTV 417
P +++++ TL I + D Y CVAEN G ++ASA LTV
Sbjct: 264 -PKSRYEIRDDH-TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 308
Score = 107 bits (267), Expect = 4e-23
Identities = 161/682 (23%), Positives = 260/682 (38%), Gaps = 77/682 (11%)
Query: 43 AFAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFR 102
+F PS+ C G P + WRK+ ELP+S + + + +L IR
Sbjct: 224 SFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYE-IRDDHTLKIRKV- 281
Query: 103 LEPGGSPSDEGDYECVAQNRFGLV-VSRKARIQAATMSD-FHVHPQATVGEEGGVARFQC 160
+ D G Y CVA+N G S +Q + F V P+ V G FQC
Sbjct: 282 -----TAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQC 336
Query: 161 QIHGLPKPLITWEKN-------RVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASN 213
+ G P+P I W + + R+++ G L IT ++ D G + C N
Sbjct: 337 EATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLN 396
Query: 214 IASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSR 273
+A I+ A L V+ + P I GP N T+ V T VL CVATG+P P + W R
Sbjct: 397 VAGSIITK-AYLEVTDVIADR-PPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILW-R 453
Query: 274 LDGRPIGVEG--IQVLGTGNLIISDVTVQHSGVYVCAANRP---------------GTRV 316
DG + + I+ L G L I + +G Y C A+ P G V
Sbjct: 454 KDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPV 513
Query: 317 R--RTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGG 374
+ R L+ AP++ +SR T + G P G
Sbjct: 514 QPPRPTDPNLIPSAPSK--PEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSW 571
Query: 375 HVRLKN-NNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAEGLPGPPRNVRAV 433
+N T I G+ P ++ A N+ G S S + + + + V
Sbjct: 572 QTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHK 631
Query: 434 SV-----------------SSTEVRVSWSEPLANTKEIIGY-VLHIRKAADPPELEYQ-- 473
V SS+ + V W+ ++ I GY +L+ A+ E ++
Sbjct: 632 QVQRELGNAVLHLHNPTVLSSSSIEVHWTVD-QQSQYIQGYKILYRPSGANHGESDWLVF 690
Query: 474 EAVSKSTFQHLVSDLEPSTAYSFYIKAYTPRGASSASVPTLASTLGEAPAPPPLSVRVL- 532
E + + ++ DL Y + + + S A TL EAP+ PP V V
Sbjct: 691 EVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSK 750
Query: 533 ---GSSSLQLLWEPWPRLAQHEGGFKLFYRP---ASKTSFTGPILLPGTVSSYNLSQLDP 586
+++ + W+P P Q+ G Y+ ++T + + G+ S + L P
Sbjct: 751 NDGNGTAILVSWQPPPEDTQN--GMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVP 808
Query: 587 TAVYEVKLLAYNQHGDG-NATVRFVSLRGASERTALSPPCDCR-KEEAANQTSTTGIVIG 644
Y V++ A G G + +F+ L + +SP ++ ++ + G
Sbjct: 809 GIRYSVEVAASTGAGSGVKSEPQFIQL--DAHGNPVSPEDQVSLAQQISDVVKQPAFIAG 866
Query: 645 IHIGVTCIIFCVLFLLFGQRGR 666
IG C I ++F ++ R R
Sbjct: 867 --IGAACWIILMVFSIWLYRHR 886
Score = 64.3 bits (155), Expect = 4e-10
Identities = 62/229 (27%), Positives = 93/229 (40%), Gaps = 20/229 (8%)
Query: 230 SGSGAYKE---PAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVE---- 282
SGS +E P I+ P +L ++ + A L C A G P P + W + G + +
Sbjct: 18 SGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYK-GGERVETDKDDP 76
Query: 283 --GIQVLGTGNLIISDV-----TVQHSGVYVCAA-NRPGTRVRRTAQGRLVVQAPAEFVQ 334
+L +G+L + + GVYVC A N G V A + + +F Q
Sbjct: 77 RSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD-DFRQ 135
Query: 335 HPQSISRPAGTTAMFTCQ-AQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPE 393
+P + G A+ CQ +G P P ++W K+G L R+ L I+
Sbjct: 136 NPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDE-RITIRGGKLMITYTRKS 194
Query: 394 DEAIYQCVAENSAGSSQAS-ARLTVLWAEGLPGPPRNVRAVSVSSTEVR 441
D Y CV N G ++ A LTVL P N+ S E +
Sbjct: 195 DAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFK 243
>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
isoform 4 precursor [Homo sapiens]
Length = 1505
Score = 162 bits (410), Expect = 1e-39
Identities = 157/576 (27%), Positives = 230/576 (39%), Gaps = 26/576 (4%)
Query: 44 FAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRL 103
F EP D + V G C+ G P R+TW K G ++ T+ + S R+
Sbjct: 35 FIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGAV-LRI 93
Query: 104 EPGGSPSDEGDYECVAQNRFG-------LVVSRKARIQAATMSDFHVHPQATVGEEGGVA 156
+P +P DE YECVAQN G L V R+ ++ + + + PQ V E A
Sbjct: 94 QPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSG-FPNIDMGPQLKVVERTRTA 152
Query: 157 RFQCQIHGLPKPLITWEKNRVPID--TDNERYTLLPKGVLQITGLRAEDGGIFHCVASNI 214
C G P P ITW K+ +P+D N R L G LQI D G + CVA+N
Sbjct: 153 TMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSEETDQGKYECVATNS 212
Query: 215 ASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRL 274
A +R S A L V P + P + + + CVA G+P P V W +
Sbjct: 213 AGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQ- 271
Query: 275 DGRPIGVEGIQVLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQ 334
+ E +G L ++DV + S Y C A + AQ + V++ +
Sbjct: 272 GAEDLTPEDDMPVGRNVLELTDV--KDSANYTCVAMSSLGVIEAVAQ--ITVKSLPKAPG 327
Query: 335 HPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTL--TISGIGP 392
P A T++ G P P ++ + G ++K + +T +I G+ P
Sbjct: 328 TPMVTENTA--TSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSP 385
Query: 393 EDEAIYQCVAENSAGSSQASARLTVLWAEGLPGP-PRNVRAVSVSSTEVRVSWSEPLANT 451
E A NS G S + E P PRNV+A +S+T + V W EP+
Sbjct: 386 NSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPN 445
Query: 452 KEIIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKAYTPRGASSASV 511
I GY ++ + P +Q+ + V L Y+ + A+T G S
Sbjct: 446 GLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSD 505
Query: 512 PTLASTLGEAPAPP-PLSVRVLGSSSLQLLWEPWPRLAQHEGGFKLFYRPASKTSFTGPI 570
P T P P L +S+ L W P PR + ++L +R G
Sbjct: 506 PIQVKTQQGVPGQPMNLRAEARSETSITLSWSP-PR-QESIIKYELLFREGDHGREVGRT 563
Query: 571 LLPGTVSSYNLSQLDPTAVYEVKLLAYNQHGDGNAT 606
P T SY + L P Y +L A + G G T
Sbjct: 564 FDPTT--SYVVEDLKPNTEYAFRLAARSPQGLGAFT 597
Score = 72.8 bits (177), Expect = 1e-12
Identities = 105/447 (23%), Positives = 172/447 (38%), Gaps = 71/447 (15%)
Query: 231 GSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEGIQVL--- 287
G A + P + P++ A C ATG+P+P V+W++ G+ + + + +
Sbjct: 26 GCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNK-KGKKVNSQRFETIEFD 84
Query: 288 ---GTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVV----QAPAEFV---QHPQ 337
G I T + VY C A + T +L V Q P+ F PQ
Sbjct: 85 ESAGAVLRIQPLRTPRDENVYECVAQNSVGEI--TVHAKLTVLREDQLPSGFPNIDMGPQ 142
Query: 338 SISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGP-GGHVRLKN-NNSTLTISGIGPEDE 395
TA C A G P P +TW K+ + P + R+K + L I D+
Sbjct: 143 LKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSEETDQ 202
Query: 396 AIYQCVAENSAGSSQAS-ARLTV-----------------LWAEGLPGPPRNVRAVSVSS 437
Y+CVA NSAG +S A L V + E +PG N+ V+V S
Sbjct: 203 GKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGS 262
Query: 438 TEVRVSWSEPLANTKEIIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPSTAYSFY 497
V W + A+ E V ++ + ++D++ S Y+
Sbjct: 263 PMPYVKWMQ-----------------GAEDLTPEDDMPVGRNVLE--LTDVKDSANYT-- 301
Query: 498 IKAYTPRGASSASVPTLASTLGEAPAPPPLSVRVLGSSSLQLLWEPWPRLAQHEGGFKLF 557
A + G A +L +AP P ++ ++S+ + W+ + + +
Sbjct: 302 CVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENT--ATSITITWD-----SGNPDPVSYY 354
Query: 558 YRPASKTSFTGPILLPG--TVSSYNLSQLDPTAVYEVKLLAYNQHGDGNATVRFVSLRGA 615
S GP + T + Y++ L P + YE+ + A N G G + V+ G
Sbjct: 355 VIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTG- 413
Query: 616 SERTALSPPCDCRKEEAANQTSTTGIV 642
E+ S P R +A ++TT IV
Sbjct: 414 -EQAPASAP---RNVQARMLSATTMIV 436
Score = 68.9 bits (167), Expect = 2e-11
Identities = 38/113 (33%), Positives = 56/113 (49%), Gaps = 4/113 (3%)
Query: 322 GRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNN 381
G + P F++ P+ +G A F CQA G+P P VTW K G+ + ++ +
Sbjct: 25 GGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFD 84
Query: 382 NSTLTISGI----GPEDEAIYQCVAENSAGSSQASARLTVLWAEGLPGPPRNV 430
S + I P DE +Y+CVA+NS G A+LTVL + LP N+
Sbjct: 85 ESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNI 137
>gi|222352127 sidekick 2 [Homo sapiens]
Length = 2172
Score = 161 bits (408), Expect = 2e-39
Identities = 158/581 (27%), Positives = 242/581 (41%), Gaps = 46/581 (7%)
Query: 46 VEPSDDVAVPG-QPIVLDCRVEGTPPVR--ITWRKNGVELPESTHSTLLANGSLMIRHFR 102
+ P + V G + L+C P ++ I W+K+GV L +G + + R
Sbjct: 219 IPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGV----------LLSGGISDHNRR 268
Query: 103 LE-PGGSPSDEGDYECVAQNRFGLVVS--RKARIQAATMSDFHVHPQATV-GEEGGVARF 158
L P + SD G YEC A R V S R A + F P+ + E V
Sbjct: 269 LTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDI 328
Query: 159 QCQIHGLPKPLITWEKNRVPIDTDN-ERYTLLPKGVLQITGLRAEDGGIFHCVASNIASI 217
CQ G+P P ITW K+ ++ + R+ G LQI+GL +D G+F C A N A
Sbjct: 329 PCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAG- 387
Query: 218 RISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSR---- 273
+ L V+ P I GP + T+ + VL C +G PRP ++W +
Sbjct: 388 EVQTSTYLAVTSIA------PNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERI 441
Query: 274 LDGRPIGVEGIQVLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFV 333
L + + L +G+L+IS + +G Y C A +R A LVV A
Sbjct: 442 LASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLAT--NSRGVDEASADLVVWARTRIT 499
Query: 334 QHPQSISRPAGTTAMFTCQAQGEPPPHV--TWLKNGQVLGPGGHVRLK-NNNSTLTISGI 390
+ PQ S GT A C +P + W K+G LG H R++ + N +L IS
Sbjct: 500 KPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQT 559
Query: 391 GPEDEAIYQCVAENSAGSSQASARLTVLWAEGLPGPPRNVRAV--SVSSTEVRVSWSEPL 448
D Y C ++ G+ SA L V LP P + A +V + ++W++P
Sbjct: 560 WSGDIGTYTCRVISAGGNDSRSAHLRV---RQLPHAPEHPVATLSTVERRAINLTWTKPF 616
Query: 449 ANTKEIIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKAYTPRGASS 508
+I Y+L + + P + K+T V L P+ +Y F + A G
Sbjct: 617 DGNSPLIRYILEMSENNAPWTVLLASVDPKAT-SVTVKGLVPARSYQFRLCAVNDVGKGQ 675
Query: 509 ASVPTLASTL-GEAPAPPPLSVRVLG--SSSLQLLWEPWPRLAQH---EGGFKLFYRPAS 562
S T +L E P PP +V G + S+ + W+P P Q+ +G +
Sbjct: 676 FSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGL 735
Query: 563 KTSFTGPILLPGTVSSYNLSQLDPTAVYEVKLLAYNQHGDG 603
+ + V++ L L YE+++ AYN G G
Sbjct: 736 PVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLG 776
Score = 124 bits (311), Expect = 4e-28
Identities = 112/392 (28%), Positives = 169/392 (43%), Gaps = 40/392 (10%)
Query: 44 FAVEP-SDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFR 102
F EP V + G +VL C EG+ P+ W N EL + + SL H
Sbjct: 28 FKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELTKFSLEYRYMITSLDRTH-- 85
Query: 103 LEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQC-Q 161
G Y C+ +NR G ++ R+ +Q A M F + G A + +
Sbjct: 86 ---------AGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIRAPR 136
Query: 162 IHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIAS--IRI 219
I P+P +TW ++ I + R + + L I A D G ++ A N + +
Sbjct: 137 IASFPQPQVTWFRDGRKIPPSS-RIAITLENTLVILSTVAPDAGRYYVQAVNDKNGDNKT 195
Query: 220 SHGARLTVSGSGSGAYK-EPAILVGPENLTLTVHQTAV-LECVATGNPRPIVS----WSR 273
S LTV G A P I++ P+N ++ + V LECVA N RP++ W +
Sbjct: 196 SQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVA--NARPLIKLHIIWKK 253
Query: 274 LDGRPIGVEGIQVLG-----TGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGR-LVVQ 327
+G+ + G L I + T +G Y C A + V +G L V
Sbjct: 254 --------DGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVL 305
Query: 328 APAEFVQHPQS-ISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKN-NNSTL 385
P +FV+ P+ I+ CQA+G PPP +TW K+ V+ R + N+ L
Sbjct: 306 EPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGL 365
Query: 386 TISGIGPEDEAIYQCVAENSAGSSQASARLTV 417
ISG+ P+D ++QC A N+AG Q S L V
Sbjct: 366 QISGLVPDDTGMFQCFARNAAGEVQTSTYLAV 397
Score = 112 bits (281), Expect = 1e-24
Identities = 140/587 (23%), Positives = 228/587 (38%), Gaps = 43/587 (7%)
Query: 44 FAVEPSDDVAVPGQPIV-LDCRVEGTPPVRITWRKNG--VELPESTHSTLLANGSLMIRH 100
F EP + + +V + C+ +G PP ITW K+ VE+ + T +G L I
Sbjct: 310 FVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQIS- 368
Query: 101 FRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQC 160
G P D G ++C A+N G V + + + P + +G C
Sbjct: 369 -----GLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLAC 423
Query: 161 QIHGLPKPLITWEKNRVPIDTDN---ERYTLLPKGVLQITGLRAEDGGIFHCVASNIASI 217
+ G P+P ITW+K + + + R+T L G L I+ D G + C+A+N +
Sbjct: 424 ETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGV 483
Query: 218 RISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVS--WSRLD 275
+ A L V + I P++ ++ A + C T +PR + W + D
Sbjct: 484 DEA-SADLVV-------WARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEK-D 534
Query: 276 GRPIGVEG---IQVLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRL--VVQAPA 330
G +G E I++ G+L IS G Y C G R+A R+ + AP
Sbjct: 535 GATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPE 594
Query: 331 EFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHV--RLKNNNSTLTIS 388
V ++ R A +T G P L+ + P + + +++T+
Sbjct: 595 HPVATLSTVERRA-INLTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVK 653
Query: 389 GIGPEDEAIYQCVAENSAGSSQAS--ARLTVLWAEGLPGPPRNVRAVSVSSTEVRVSWSE 446
G+ P ++ A N G Q S L E PP+NV A ++ + + W
Sbjct: 654 GLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQP 713
Query: 447 PLANTKEII--GYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKAYTPR 504
P + + I GY++ A P +++ L+ DL T Y + AY
Sbjct: 714 PPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSA 773
Query: 505 GASSASVPTLASTLGEAPAPPPLSV--RVLGSSSLQLLWE-PWPRLAQH-EGGFKLF-YR 559
G S TL P PP +V S++++ W P P+ G+KL +
Sbjct: 774 GLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWE 833
Query: 560 PASKTSFTGPILLPGTVSSYN---LSQLDPTAVYEVKLLAYNQHGDG 603
P + T P S + +S L Y +L + GDG
Sbjct: 834 PEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDG 880
Score = 95.5 bits (236), Expect = 2e-19
Identities = 145/600 (24%), Positives = 232/600 (38%), Gaps = 58/600 (9%)
Query: 48 PSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFR-LEPG 106
P D + G +VL C G P ITW+K +LA+GS+ + F LE G
Sbjct: 408 PLDSTVIDGMSVVLACETSGAPRPAITWQKG---------ERILASGSVQLPRFTPLESG 458
Query: 107 G---SP---SDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQC 160
SP SD G Y C+A N G V A + + PQ +G A C
Sbjct: 459 SLLISPTHISDAGTYTCLATNSRG-VDEASADLVVWARTRITKPPQDQSVIKGTQASMVC 517
Query: 161 QIHGLPKPLIT--WEKNRVPIDTDNE-RYTLLPKGVLQITGLRAEDGGIFHCVASNIASI 217
+ P+ I WEK+ + T++ R L G L I+ + D G + C + A
Sbjct: 518 GVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVIS-AGG 576
Query: 218 RISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNP---RPIVSWSRL 274
S A L V A L E + + T + GN R I+ S
Sbjct: 577 NDSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFD----GNSPLIRYILEMSEN 632
Query: 275 DGR-PIGVEGIQVLGTGNLIISDVTVQHSGVYVCAANRPGTRV--RRTAQGRLVVQAPAE 331
+ + + + T + V + +CA N G + T + L + P
Sbjct: 633 NAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTA 692
Query: 332 FVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLG------PGGHVRLKNNNSTL 385
PQ++ T Q Q P H + G ++ P G+ + KN
Sbjct: 693 ---PPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGY-QFKNITDA- 747
Query: 386 TISGIGPEDEAIY-----QCVAENSAGSSQASARLTVLWAEGLPG-PPRNVRAVSVSSTE 439
++ + ED I+ + A NSAG S+++T +G+P PP NV A + +ST
Sbjct: 748 DVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTT 807
Query: 440 VRVSWSEPLANTKEIIGYVLHIRKAADPPELEYQEAV--SKSTFQH-----LVSDLEPST 492
+R +W+ P + + I G + A PE E + + ++ FQ VS L+ T
Sbjct: 808 IRFTWNAP--SPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFT 865
Query: 493 AYSFYIKAYTPRGASSASVPTLASTLGEAPAPPP-LSVRVLGSSSLQLLWEPWPRLAQHE 551
Y + +T G S P L T + P P LS + +SL++ W+
Sbjct: 866 EYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGIL 925
Query: 552 GGFKLFYRPASKTSFTGPILLPGTVSSYNLSQLDPTAVYEVKLLAYNQHGDGNATVRFVS 611
G+++ + ++T+ LP Y ++ L Y +++ A G G + +S
Sbjct: 926 TGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTIS 985
Score = 59.3 bits (142), Expect = 1e-08
Identities = 63/249 (25%), Positives = 104/249 (41%), Gaps = 32/249 (12%)
Query: 386 TISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAE-GLPGPPRN--VRAVSVSSTEVRV 442
T +G+ PE +++ A+ G +A+ L V + P PP V+ V + V +
Sbjct: 1361 TATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLL 1420
Query: 443 SWSEPLANTKEIIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKAYT 502
SW + Y + R+ + +VS + +V L+P T+Y F +KA
Sbjct: 1421 SWEPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATN 1480
Query: 503 PRGASSASVPTLA-STLGEAP--APPPLSVRVLGSSSLQLLWEPWPRLAQHEG---GFKL 556
G S S + + +TL AP AP LSV ++S+ + W+P P + G GF++
Sbjct: 1481 DIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQP-PAEDKINGILLGFRI 1539
Query: 557 FYRPASKTSFTGPILL----PG------------------TVSSYNLSQLDPTAVYEVKL 594
YR G L PG +++ Y L L+ YE+++
Sbjct: 1540 RYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRM 1599
Query: 595 LAYNQHGDG 603
YN G+G
Sbjct: 1600 SVYNAVGEG 1608
Score = 58.9 bits (141), Expect = 2e-08
Identities = 111/527 (21%), Positives = 188/527 (35%), Gaps = 44/527 (8%)
Query: 48 PSDDVAVPGQPIVLDCRVEGTPPV--RITWRKNGVELPESTHSTLLA--NGSLMIRHFRL 103
P D + G + C V P V R W K+G L +H + NGSL I
Sbjct: 502 PQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTW- 560
Query: 104 EPGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVG--EEGGVARFQCQ 161
D G Y C + G SR A ++ + HP AT+ E + +
Sbjct: 561 -----SGDIGTYTCRVISAGGND-SRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTK 614
Query: 162 IHGLPKPLITWEKNRVPIDTDNERYTLL-----PKGV-LQITGLRAEDGGIFH-CVASNI 214
PLI + + + +N +T+L PK + + GL F C +++
Sbjct: 615 PFDGNSPLIRYI---LEMSENNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDV 671
Query: 215 ASIRISHGA-RLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSR 273
+ S R+++ A + I G N ++ + E G + +
Sbjct: 672 GKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYC 731
Query: 274 LDGRPIGVE--GIQVLGTGNLIISDVTV-QHSGVYVCAANRPGTRVRRTAQGRLVVQAPA 330
L G P+G + I NL++ D+ + + + V A N G V + +Q
Sbjct: 732 LAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVP 791
Query: 331 EFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNG------------QVLGPGGHVRL 378
TT FT A P + + G +V
Sbjct: 792 TVPPGNVHAEATNSTTIRFTWNAPS--PQFINGINQGYKLIAWEPEQEEEVTMVTARPNF 849
Query: 379 KNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAEGLPGPPRNVRAVSVSST 438
+++ +SG+ E + + G S V E +PGP ++ + T
Sbjct: 850 QDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDT 909
Query: 439 EVRVSWSEPLANTKEIIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPSTAYSFYI 498
++VSW EP + GY + + + + T ++ V+ L T Y+ +
Sbjct: 910 SLKVSWQEPGEKNGILTGYRISWEE-YNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEV 968
Query: 499 KAYTPRGASSASVPTLASTL-GEAPAPPP-LSVRVLGSSSLQLLWEP 543
A T +G S T++S + E P PP L + +G S+ L + P
Sbjct: 969 AAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQFRP 1015
Score = 56.2 bits (134), Expect = 1e-07
Identities = 57/231 (24%), Positives = 102/231 (44%), Gaps = 6/231 (2%)
Query: 386 TISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAEGLPGP-PRNVRAVSVSSTEVRVSW 444
TI + E Q A N+ GS S + E +P P NV A++ +S+ + V W
Sbjct: 1161 TIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRW 1220
Query: 445 SE-PLANTKEII-GYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKAYT 502
SE P A+ ++ GY + ++ + + S+ ++ L Y + A+T
Sbjct: 1221 SEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFT 1280
Query: 503 PRGASSAS-VPTLASTLGEAPAPP-PLSVRVLGSSSLQLLWEPWPRLAQHEGGFKLFYRP 560
G S S P L TL + P PP + + ++S++L+W+P +++ +R
Sbjct: 1281 RIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRL 1340
Query: 561 ASKTSFTGPI-LLPGTVSSYNLSQLDPTAVYEVKLLAYNQHGDGNATVRFV 610
+ T+ T + +L + Y + L P +VY ++ A + G G A V
Sbjct: 1341 NTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALV 1391
Score = 55.5 bits (132), Expect = 2e-07
Identities = 47/198 (23%), Positives = 83/198 (41%), Gaps = 7/198 (3%)
Query: 421 EGLPGPPRNVRAVSVSSTEVRVSWSEPLANTKEIIGYVLHIRKAADPPELEYQEAVSKST 480
+ +PGPP + V +T VR+ W P A I+ Y + R E ++ S
Sbjct: 1298 DDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSA 1357
Query: 481 FQHLVSDLEPSTAYSFYIKAYTPRGASSASVPTLAST----LGEAPAPPPLSVRVLGSSS 536
Q+ + L+P + Y F I A T +G A+ + +T + P+ P + + + S
Sbjct: 1358 RQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARS 1417
Query: 537 LQLLWEPWPRLAQHEGGFKLFYR--PASKTSFTGPILLPGTVSSYNLSQLDPTAVYEVKL 594
+ L WEP + + R P+ + + + SS+ + +L P Y+ ++
Sbjct: 1418 VLLSWEPGSDGLSPVRYYTIQTRELPSGRWALHS-ASVSHNASSFIVDRLKPFTSYKFRV 1476
Query: 595 LAYNQHGDGNATVRFVSL 612
A N GD + SL
Sbjct: 1477 KATNDIGDSEFSEESESL 1494
Score = 51.6 bits (122), Expect = 3e-06
Identities = 52/191 (27%), Positives = 84/191 (43%), Gaps = 17/191 (8%)
Query: 427 PRNVRAVSVSSTEVRVSWSEPLANTK-----EIIGYVLHIRKAADPPELEYQEAVSKSTF 481
P NV + S T + + W PL + E +GY + ++ + +
Sbjct: 1100 PANVSLRTASETSLWLRWM-PLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVER 1158
Query: 482 QHLVSDLEPSTAYSFYIKAYTPRGASSASVPTLASTLGEAPAPPPLSVRVLG--SSSLQL 539
+ + DLE T Y ++A+ G+ S + T P+ P +V L SSS+ +
Sbjct: 1159 DYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLV 1218
Query: 540 LWEPWPRLAQHEG---GFKLFYRPASKTSFTGP--ILLPGTVS-SYNLSQLDPTAVYEVK 593
W P A G G+K+ Y+ K S T P L+ G S S L+ L +YEV+
Sbjct: 1219 RWSEVPE-ADRNGLVLGYKVMYK--EKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQ 1275
Query: 594 LLAYNQHGDGN 604
+LA+ + GDG+
Sbjct: 1276 VLAFTRIGDGS 1286
Score = 51.2 bits (121), Expect = 4e-06
Identities = 61/250 (24%), Positives = 97/250 (38%), Gaps = 35/250 (14%)
Query: 378 LKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASAR-LTVLWAEGLPGPPRNVRAVSVS 436
L N ++G+ + A S G Q SA ++ LPGPP N+ ++
Sbjct: 946 LPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIG 1005
Query: 437 STEVRVSWSEPLANTKEI--------IGYV------LHIRKAADPPELEYQEAVSKSTFQ 482
V + + I +G V L I + ++ P+ E
Sbjct: 1006 PRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSME-------- 1057
Query: 483 HLVSDLEPSTAYSFYIKAYTPRGASSASVPTLASTLGEAP---APPPLSVRVLGSSSLQL 539
V DL P T YSF ++ G S S P+ +AP AP +S+R +SL L
Sbjct: 1058 --VPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWL 1115
Query: 540 LWEPWPRLAQHEG-----GFKLFYRPASKTSFTGPILLPGTVS-SYNLSQLDPTAVYEVK 593
W P P + ++ G G+K+ Y + T ++ V Y + L+ Y V+
Sbjct: 1116 RWMPLPEM-EYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQ 1174
Query: 594 LLAYNQHGDG 603
+ A+N G G
Sbjct: 1175 VQAFNAIGSG 1184
Score = 49.7 bits (117), Expect = 1e-05
Identities = 42/163 (25%), Positives = 71/163 (43%), Gaps = 4/163 (2%)
Query: 404 NSAGSSQASARLTVLWAEGLP-GPPRNVRAVSVSSTEVRVSWSEPLANTK--EIIGYVLH 460
N+ G +S V E +P PRNV ++T++ V+W P +++ +I GY ++
Sbjct: 1603 NAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIY 1662
Query: 461 IRKAADPPELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKAYTPRGASSASVPTLASTLGE 520
+A E + + + + +L TAY + A+ G S PT T
Sbjct: 1663 FWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQA 1722
Query: 521 AP-APPPLSVRVLGSSSLQLLWEPWPRLAQHEGGFKLFYRPAS 562
AP AP + L ++S+ + WE G++L Y P S
Sbjct: 1723 APSAPSSVKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPCS 1765
Score = 48.9 bits (115), Expect = 2e-05
Identities = 51/209 (24%), Positives = 81/209 (38%), Gaps = 8/209 (3%)
Query: 402 AENSAGSSQASARLTVLWAEGLPGPPRNVRAVSVSSTEVRVSWSEPLANTKEIIGYVLHI 461
A N+AG S + P P +V+ +++T V VSW P + GY L +
Sbjct: 1702 AFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGILEGYRL-V 1760
Query: 462 RKAADP----PELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKAYTPRGASSASVPTLAST 517
+ P ++ + S V DL Y F I+A T
Sbjct: 1761 YEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGPEIEANVTTGP 1820
Query: 518 LGEAPAPPPLSVRVLGSSSLQLLWEPWPRLAQHEGGFKLFYRPASKTSFTGPIL-LPGTV 576
AP PP + + V SS++ + W + + RP+ + + I +P V
Sbjct: 1821 GEGAPGPPGVPIIVRYSSAIAIHWSSGDPGKGPITRYVIEARPSDEGLWDILIKDIPKEV 1880
Query: 577 SSYNLSQ--LDPTAVYEVKLLAYNQHGDG 603
SSY S L P Y+ +++A N +G G
Sbjct: 1881 SSYTFSMDILKPGVSYDFRVIAVNDYGFG 1909
Score = 47.4 bits (111), Expect = 5e-05
Identities = 63/286 (22%), Positives = 113/286 (39%), Gaps = 37/286 (12%)
Query: 378 LKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASAR---LTVLWAEGLPGPPRNVRAVS 434
+ +N S+ + + P ++ A N G S+ S LT L A P + +V+
Sbjct: 1454 VSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAA--PDEAPTILSVT 1511
Query: 435 V-SSTEVRVSWSEPLANTKE--IIGYVLHIR------------KAADPPELEYQEAVSKS 479
++T V + W P + ++G+ + R + + P + E S
Sbjct: 1512 PHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMY 1571
Query: 480 TFQHL---------VSDLEPSTAYSFYIKAYTPRGASSASVPTLASTLGEAPAPPPLSVR 530
+ ++L + +L Y + Y G +S P P P +V
Sbjct: 1572 SMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVV 1631
Query: 531 VLGSSSLQL--LWEPWPRLAQHEG--GFKLFYRPASKTSFTGPI-LLPGTVSSYNLSQLD 585
V G+++ QL WEP P +Q+ G+K+++ A + + T + L +S L L
Sbjct: 1632 VHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLT 1691
Query: 586 PTAVYEVKLLAYNQHGDGNATVRFVSLRGASERTALSPPCDCRKEE 631
Y V + A+N GDG R +G +++ A S P + E
Sbjct: 1692 GYTAYMVSVAAFNAAGDG---PRSTPTQGQTQQAAPSAPSSVKFSE 1734
>gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo
sapiens]
Length = 1248
Score = 161 bits (407), Expect = 3e-39
Identities = 160/601 (26%), Positives = 253/601 (42%), Gaps = 54/601 (8%)
Query: 27 LLLPAPSEGLGHSAELAFAVEPSDD-VAVPGQPIVLDCRVEGTPPVRITWRKNGVELPES 85
L + A + + L F S VA+ GQP+VL+C EG P I W + +P
Sbjct: 222 LRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPAD 281
Query: 86 THSTLLANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVH- 144
+ N +L + L+ G D+G+Y C+A+N G +R A + + +H
Sbjct: 282 RVTYQNHNKTLQL----LKVG--EEDDGEYRCLAENSLGS--ARHAYYVTVEAAPYWLHK 333
Query: 145 PQATVGEEGGVARFQCQIHGLPKPLITWEKNRVPID--TDNERYTLLPKGVLQITGLRAE 202
PQ+ + G AR CQ+ G P+P +TW N +P++ +++Y + +G L ++ ++
Sbjct: 334 PQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRI-QRGALILSNVQPS 392
Query: 203 DGGIFHCVASNIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQ--TAVLECV 260
D + C A N HG L ++ + + PA ++ +N T Q TA L C
Sbjct: 393 DTMVTQCEARN------RHG--LLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCK 444
Query: 261 ATGNPRPIVSWSRLDGRPI-GVEGIQVLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRT 319
A G P P V W DG + E G L I D+ +G Y C A V T
Sbjct: 445 AFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNV--T 502
Query: 320 AQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEP--PPHVTWLKNGQVLGP-GGHV 376
L V+ + Q P+S G+ FTCQA +P P +TW +G+ L G
Sbjct: 503 IMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSD 562
Query: 377 RLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAEGLPGP-PRNVRA--V 433
+ + L I + D+ Y CVA ++ A+L V+ G PGP PR V +
Sbjct: 563 KYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVV---GSPGPVPRLVLSDLH 619
Query: 434 SVSSTEVRVSWSEPLANTKEIIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPSTA 493
++ ++VRVSWS + I Y + PE Y L P
Sbjct: 620 LLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVH 679
Query: 494 YSFYIKAYTPRGASSAS-VPTLASTLGEAPAPPPLSVRVLG--SSSLQLLWEP--WPRLA 548
Y+F + A G S V T AP P+ V+ G ++++ + W+P W
Sbjct: 680 YTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWN 739
Query: 549 QHEGGFKLFYRPA------SKTSFTGPILLPGTVSSYNLSQLDPTAVYEVKLLAYNQHGD 602
+ +++ +RP + + P L+ S++ YE+K+ A N G
Sbjct: 740 APQVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTF--------VPYEIKVQAVNSQGK 791
Query: 603 G 603
G
Sbjct: 792 G 792
Score = 108 bits (271), Expect = 2e-23
Identities = 113/435 (25%), Positives = 167/435 (38%), Gaps = 57/435 (13%)
Query: 16 LWPRLLL-PLLLLLLPAP---SEGLGHSAELAFAVEPSDDVAVPGQPIVLDCRVEGTPPV 71
+WP LL P LL+ +P + + V P+DD++ L C G P V
Sbjct: 8 VWPLLLCSPCLLIQIPEELMEPPVITEQSPRRLVVFPTDDIS-------LKCEASGKPEV 60
Query: 72 RITWRKNGVEL-------------PESTHSTLLANGSLMIRHFRLEPGGSPSDEGDYECV 118
+ W ++GV P S T+ N S + F +G Y C
Sbjct: 61 QFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRF----------QGIYRCF 110
Query: 119 AQNRFGLVVSRKARIQAATMSDFHVHPQATVG----EEGGVARFQCQIHGLPKPL-ITWE 173
A N+ G +S + R+ A + P+ TV EEG C +PL I W
Sbjct: 111 ASNKLGTAMSHEIRLMAEGAPKW---PKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWM 167
Query: 174 KNRVPIDTDNERYTLLPKGVLQITGLRAEDGG---IFHCVASNIASIRISHGARLTVSGS 230
+++ +ER T+ G L + D I H +I L V +
Sbjct: 168 NSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKAT 227
Query: 231 GSGAYKEPAILV---GPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEGIQVL 287
S ++P +L +L Q VLEC+A G P P + W R G P+ + +
Sbjct: 228 NSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSG-PMPADRVTYQ 286
Query: 288 GTGNLI-ISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTT 346
+ + V + G Y C A R + V+A ++ PQS G T
Sbjct: 287 NHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYY--VTVEAAPYWLHKPQSHLYGPGET 344
Query: 347 AMFTCQAQGEPPPHVTWLKNG---QVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAE 403
A CQ QG P P VTW NG + L R++ L +S + P D + QC A
Sbjct: 345 ARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQ--RGALILSNVQPSDTMVTQCEAR 402
Query: 404 NSAGSSQASARLTVL 418
N G A+A + V+
Sbjct: 403 NRHGLLLANAYIYVV 417
Score = 104 bits (260), Expect = 3e-22
Identities = 142/605 (23%), Positives = 246/605 (40%), Gaps = 80/605 (13%)
Query: 47 EPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPE--STHSTLLANGSLMIRHFRLE 104
+P + PG+ LDC+V+G P +TWR NG+ + E + G+L++ + +
Sbjct: 333 KPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQ-- 390
Query: 105 PGGSPSDEGDYECVAQNRFGLVVSRK----ARIQAATMSDFHVHPQATVGEEGGVARFQC 160
PSD +C A+NR GL+++ ++ A ++ Q + +G A C
Sbjct: 391 ----PSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILT---ADNQTYMAVQGSTAYLLC 443
Query: 161 QIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRIS 220
+ G P P + W +ER+ G L I L+A D G + C+A+N + ++
Sbjct: 444 KAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQN-NVT 502
Query: 221 HGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNP--RPIVSWSRLDGRP 278
A L V + I GP + C A+ +P +P ++W R DGR
Sbjct: 503 IMANLKVKDATQ-------ITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITW-RGDGRD 554
Query: 279 I---GVEGIQVLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAP------ 329
+ G + G L+I + G Y C A+ V AQ LVV +P
Sbjct: 555 LQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQ-LLVVGSPGPVPRL 613
Query: 330 --AEFVQHPQSISRPAGTTA--------MFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLK 379
++ QS R + + A + + + + W G+V G
Sbjct: 614 VLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPG-------- 665
Query: 380 NNNSTLTISGIGPEDEAIYQCVAENSAGSSQAS-ARLTVLWAEGLPGP-PRNVRAVSVSS 437
N T T + P ++ A N G + S TV+ E P P +V+ +
Sbjct: 666 --NQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNET 723
Query: 438 TEVRVSWSEPLA----NTKEIIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPSTA 493
T + ++W +PL N ++ V + P +QE + F +VS+
Sbjct: 724 TNMVITW-KPLRWMDWNAPQVQYRVQWRPQGTRGP---WQEQIVSDPFL-VVSNTSTFVP 778
Query: 494 YSFYIKAYTPRGASSASVPTLASTLGEAP-APPPLS-VRVLGSSSLQLLWEPWPRLAQHE 551
Y ++A +G T+ + + P A P L + +L SS++ + W P LAQ +
Sbjct: 779 YEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVD-LAQVK 837
Query: 552 GGFK----LFYRPASKTSFT------GPILLPGTVSSYNLSQLDPTAVYEVKLLAYNQHG 601
G + ++R S+ + +++P +S LS L P + Y +++ A+N G
Sbjct: 838 GHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRG 897
Query: 602 DGNAT 606
G A+
Sbjct: 898 SGPAS 902
Score = 63.5 bits (153), Expect = 7e-10
Identities = 118/514 (22%), Positives = 190/514 (36%), Gaps = 81/514 (15%)
Query: 48 PSDDVAVPGQPIVLDCRVEGTPPVR--ITWRKNGVELPESTHST--LLANGSLMIRHFRL 103
P + G + C+ P ++ ITWR +G +L E S + +G L+I
Sbjct: 519 PRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDY 578
Query: 104 EPGGSPSDEGDYECVAQNRFGLVVSRKARIQAAT--------MSDFHVHPQATVGEEGGV 155
SD+G+Y CVA +V SR + + +SD H+ Q+ V V
Sbjct: 579 ------SDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVR----V 628
Query: 156 ARFQCQIHGLP--KPLITWE-KNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVAS 212
+ + H P K I +E K P E++ L K T + H
Sbjct: 629 SWSPAEDHNAPIEKYDIEFEDKEMAP-----EKWYSLGKVPGNQTSTTLKLSPYVHYTFR 683
Query: 213 NIASIRISHGARLTVSGS----GSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPI 268
A + G VS + + K P + G N T + V T P
Sbjct: 684 VTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNM--------VITWKPLRW 735
Query: 269 VSWS------RLDGRPIGVEGI---QVLGTGNLIISDV-TVQHSGVYVCAANRPGTRVRR 318
+ W+ R+ RP G G Q++ L++S+ T + V A N G +
Sbjct: 736 MDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQG----K 791
Query: 319 TAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPP-------------HVTWLK 365
+ ++ + E +PQ+I G + + + P +VT+ +
Sbjct: 792 GPEPQVTIGYSGE--DYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWR 849
Query: 366 NGQVLGPG------GHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTVLW 419
G HV + N +++ +SG+ P + A N GS AS T
Sbjct: 850 EGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPAS-EFTFST 908
Query: 420 AEGLPGPPRNVRAVSVSSTEVRVSWSEPLANTKEIIGYVL--HIRKAADPPELEYQEAVS 477
EG+PG P + S+T + + W PL++ + GYVL H +L +
Sbjct: 909 PEGVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGKGQLSF-NLRD 967
Query: 478 KSTFQHLVSDLEPSTAYSFYIKAYTPRGASSASV 511
H ++DL P Y F ++A T G A V
Sbjct: 968 PELRTHNLTDLSPHLRYRFQLQATTKEGPGEAIV 1001
Score = 50.8 bits (120), Expect = 5e-06
Identities = 41/141 (29%), Positives = 64/141 (45%), Gaps = 14/141 (9%)
Query: 476 VSKSTFQHLVSDLEPSTAYSFYIKAYTPRGASSASVPTLASTLGEAPAPPPLSVRVLGSS 535
V +T ++S L P ++Y ++A+ RG+ AS T ++ G P L + ++
Sbjct: 868 VPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFSTPEGVPGHPEALHLECQSNT 927
Query: 536 SLQLLWEPWPRLAQHEG---GFKLFYRP-----ASKTSFTGPILLPGTVSSYNLSQLDPT 587
SL L W+P H G G+ L Y P + SF L + ++NL+ L P
Sbjct: 928 SLLLRWQP---PLSHNGVLTGYVLSYHPLDEGGKGQLSFN---LRDPELRTHNLTDLSPH 981
Query: 588 AVYEVKLLAYNQHGDGNATVR 608
Y +L A + G G A VR
Sbjct: 982 LRYRFQLQATTKEGPGEAIVR 1002
>gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo
sapiens]
Length = 1253
Score = 161 bits (407), Expect = 3e-39
Identities = 160/601 (26%), Positives = 253/601 (42%), Gaps = 54/601 (8%)
Query: 27 LLLPAPSEGLGHSAELAFAVEPSDD-VAVPGQPIVLDCRVEGTPPVRITWRKNGVELPES 85
L + A + + L F S VA+ GQP+VL+C EG P I W + +P
Sbjct: 227 LRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPAD 286
Query: 86 THSTLLANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVH- 144
+ N +L + L+ G D+G+Y C+A+N G +R A + + +H
Sbjct: 287 RVTYQNHNKTLQL----LKVG--EEDDGEYRCLAENSLGS--ARHAYYVTVEAAPYWLHK 338
Query: 145 PQATVGEEGGVARFQCQIHGLPKPLITWEKNRVPID--TDNERYTLLPKGVLQITGLRAE 202
PQ+ + G AR CQ+ G P+P +TW N +P++ +++Y + +G L ++ ++
Sbjct: 339 PQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRI-QRGALILSNVQPS 397
Query: 203 DGGIFHCVASNIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQ--TAVLECV 260
D + C A N HG L ++ + + PA ++ +N T Q TA L C
Sbjct: 398 DTMVTQCEARN------RHG--LLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCK 449
Query: 261 ATGNPRPIVSWSRLDGRPI-GVEGIQVLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRT 319
A G P P V W DG + E G L I D+ +G Y C A V T
Sbjct: 450 AFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNV--T 507
Query: 320 AQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEP--PPHVTWLKNGQVLGP-GGHV 376
L V+ + Q P+S G+ FTCQA +P P +TW +G+ L G
Sbjct: 508 IMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSD 567
Query: 377 RLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAEGLPGP-PRNVRA--V 433
+ + L I + D+ Y CVA ++ A+L V+ G PGP PR V +
Sbjct: 568 KYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVV---GSPGPVPRLVLSDLH 624
Query: 434 SVSSTEVRVSWSEPLANTKEIIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPSTA 493
++ ++VRVSWS + I Y + PE Y L P
Sbjct: 625 LLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVH 684
Query: 494 YSFYIKAYTPRGASSAS-VPTLASTLGEAPAPPPLSVRVLG--SSSLQLLWEP--WPRLA 548
Y+F + A G S V T AP P+ V+ G ++++ + W+P W
Sbjct: 685 YTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWN 744
Query: 549 QHEGGFKLFYRPA------SKTSFTGPILLPGTVSSYNLSQLDPTAVYEVKLLAYNQHGD 602
+ +++ +RP + + P L+ S++ YE+K+ A N G
Sbjct: 745 APQVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTF--------VPYEIKVQAVNSQGK 796
Query: 603 G 603
G
Sbjct: 797 G 797
Score = 114 bits (286), Expect = 3e-25
Identities = 118/434 (27%), Positives = 167/434 (38%), Gaps = 50/434 (11%)
Query: 16 LWPRLLL-PLLLLLLPAPSEGLGHSAELAFAVEPSDD--VAVPGQPIVLDCRVEGTPPVR 72
+WP LL P LL+ +P EG H E E S V P I L C G P V+
Sbjct: 8 VWPLLLCSPCLLIQIPEEYEG-HHVMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQ 66
Query: 73 ITWRKNGVEL-------------PESTHSTLLANGSLMIRHFRLEPGGSPSDEGDYECVA 119
W ++GV P S T+ N S + F +G Y C A
Sbjct: 67 FRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRF----------QGIYRCFA 116
Query: 120 QNRFGLVVSRKARIQAATMSDFHVHPQATVG----EEGGVARFQCQIHGLPKPL-ITWEK 174
N+ G +S + R+ A + P+ TV EEG C +PL I W
Sbjct: 117 SNKLGTAMSHEIRLMAEGAPKW---PKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMN 173
Query: 175 NRVPIDTDNERYTLLPKGVLQITGLRAEDGG---IFHCVASNIASIRISHGARLTVSGSG 231
+++ +ER T+ G L + D I H +I L V +
Sbjct: 174 SKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATN 233
Query: 232 SGAYKEPAILV---GPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEGIQVLG 288
S ++P +L +L Q VLEC+A G P P + W R G P+ + +
Sbjct: 234 SMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSG-PMPADRVTYQN 292
Query: 289 TGNLI-ISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTA 347
+ + V + G Y C A R + V+A ++ PQS G TA
Sbjct: 293 HNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYY--VTVEAAPYWLHKPQSHLYGPGETA 350
Query: 348 MFTCQAQGEPPPHVTWLKNG---QVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAEN 404
CQ QG P P VTW NG + L R++ L +S + P D + QC A N
Sbjct: 351 RLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQ--RGALILSNVQPSDTMVTQCEARN 408
Query: 405 SAGSSQASARLTVL 418
G A+A + V+
Sbjct: 409 RHGLLLANAYIYVV 422
Score = 104 bits (260), Expect = 3e-22
Identities = 142/605 (23%), Positives = 246/605 (40%), Gaps = 80/605 (13%)
Query: 47 EPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPE--STHSTLLANGSLMIRHFRLE 104
+P + PG+ LDC+V+G P +TWR NG+ + E + G+L++ + +
Sbjct: 338 KPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQ-- 395
Query: 105 PGGSPSDEGDYECVAQNRFGLVVSRK----ARIQAATMSDFHVHPQATVGEEGGVARFQC 160
PSD +C A+NR GL+++ ++ A ++ Q + +G A C
Sbjct: 396 ----PSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILT---ADNQTYMAVQGSTAYLLC 448
Query: 161 QIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRIS 220
+ G P P + W +ER+ G L I L+A D G + C+A+N + ++
Sbjct: 449 KAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQN-NVT 507
Query: 221 HGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNP--RPIVSWSRLDGRP 278
A L V + I GP + C A+ +P +P ++W R DGR
Sbjct: 508 IMANLKVKDATQ-------ITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITW-RGDGRD 559
Query: 279 I---GVEGIQVLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAP------ 329
+ G + G L+I + G Y C A+ V AQ LVV +P
Sbjct: 560 LQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQ-LLVVGSPGPVPRL 618
Query: 330 --AEFVQHPQSISRPAGTTA--------MFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLK 379
++ QS R + + A + + + + W G+V G
Sbjct: 619 VLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPG-------- 670
Query: 380 NNNSTLTISGIGPEDEAIYQCVAENSAGSSQAS-ARLTVLWAEGLPGP-PRNVRAVSVSS 437
N T T + P ++ A N G + S TV+ E P P +V+ +
Sbjct: 671 --NQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNET 728
Query: 438 TEVRVSWSEPLA----NTKEIIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPSTA 493
T + ++W +PL N ++ V + P +QE + F +VS+
Sbjct: 729 TNMVITW-KPLRWMDWNAPQVQYRVQWRPQGTRGP---WQEQIVSDPFL-VVSNTSTFVP 783
Query: 494 YSFYIKAYTPRGASSASVPTLASTLGEAP-APPPLS-VRVLGSSSLQLLWEPWPRLAQHE 551
Y ++A +G T+ + + P A P L + +L SS++ + W P LAQ +
Sbjct: 784 YEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVD-LAQVK 842
Query: 552 GGFK----LFYRPASKTSFT------GPILLPGTVSSYNLSQLDPTAVYEVKLLAYNQHG 601
G + ++R S+ + +++P +S LS L P + Y +++ A+N G
Sbjct: 843 GHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRG 902
Query: 602 DGNAT 606
G A+
Sbjct: 903 SGPAS 907
Score = 63.5 bits (153), Expect = 7e-10
Identities = 118/514 (22%), Positives = 190/514 (36%), Gaps = 81/514 (15%)
Query: 48 PSDDVAVPGQPIVLDCRVEGTPPVR--ITWRKNGVELPESTHST--LLANGSLMIRHFRL 103
P + G + C+ P ++ ITWR +G +L E S + +G L+I
Sbjct: 524 PRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDY 583
Query: 104 EPGGSPSDEGDYECVAQNRFGLVVSRKARIQAAT--------MSDFHVHPQATVGEEGGV 155
SD+G+Y CVA +V SR + + +SD H+ Q+ V V
Sbjct: 584 ------SDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVR----V 633
Query: 156 ARFQCQIHGLP--KPLITWE-KNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVAS 212
+ + H P K I +E K P E++ L K T + H
Sbjct: 634 SWSPAEDHNAPIEKYDIEFEDKEMAP-----EKWYSLGKVPGNQTSTTLKLSPYVHYTFR 688
Query: 213 NIASIRISHGARLTVSGS----GSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPI 268
A + G VS + + K P + G N T + V T P
Sbjct: 689 VTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNM--------VITWKPLRW 740
Query: 269 VSWS------RLDGRPIGVEGI---QVLGTGNLIISDV-TVQHSGVYVCAANRPGTRVRR 318
+ W+ R+ RP G G Q++ L++S+ T + V A N G +
Sbjct: 741 MDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQG----K 796
Query: 319 TAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPP-------------HVTWLK 365
+ ++ + E +PQ+I G + + + P +VT+ +
Sbjct: 797 GPEPQVTIGYSGE--DYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWR 854
Query: 366 NGQVLGPG------GHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTVLW 419
G HV + N +++ +SG+ P + A N GS AS T
Sbjct: 855 EGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPAS-EFTFST 913
Query: 420 AEGLPGPPRNVRAVSVSSTEVRVSWSEPLANTKEIIGYVL--HIRKAADPPELEYQEAVS 477
EG+PG P + S+T + + W PL++ + GYVL H +L +
Sbjct: 914 PEGVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGKGQLSF-NLRD 972
Query: 478 KSTFQHLVSDLEPSTAYSFYIKAYTPRGASSASV 511
H ++DL P Y F ++A T G A V
Sbjct: 973 PELRTHNLTDLSPHLRYRFQLQATTKEGPGEAIV 1006
Score = 50.8 bits (120), Expect = 5e-06
Identities = 41/141 (29%), Positives = 64/141 (45%), Gaps = 14/141 (9%)
Query: 476 VSKSTFQHLVSDLEPSTAYSFYIKAYTPRGASSASVPTLASTLGEAPAPPPLSVRVLGSS 535
V +T ++S L P ++Y ++A+ RG+ AS T ++ G P L + ++
Sbjct: 873 VPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFSTPEGVPGHPEALHLECQSNT 932
Query: 536 SLQLLWEPWPRLAQHEG---GFKLFYRP-----ASKTSFTGPILLPGTVSSYNLSQLDPT 587
SL L W+P H G G+ L Y P + SF L + ++NL+ L P
Sbjct: 933 SLLLRWQP---PLSHNGVLTGYVLSYHPLDEGGKGQLSFN---LRDPELRTHNLTDLSPH 986
Query: 588 AVYEVKLLAYNQHGDGNATVR 608
Y +L A + G G A VR
Sbjct: 987 LRYRFQLQATTKEGPGEAIVR 1007
>gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo
sapiens]
Length = 1257
Score = 161 bits (407), Expect = 3e-39
Identities = 160/601 (26%), Positives = 253/601 (42%), Gaps = 54/601 (8%)
Query: 27 LLLPAPSEGLGHSAELAFAVEPSDD-VAVPGQPIVLDCRVEGTPPVRITWRKNGVELPES 85
L + A + + L F S VA+ GQP+VL+C EG P I W + +P
Sbjct: 227 LRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPAD 286
Query: 86 THSTLLANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVH- 144
+ N +L + L+ G D+G+Y C+A+N G +R A + + +H
Sbjct: 287 RVTYQNHNKTLQL----LKVG--EEDDGEYRCLAENSLGS--ARHAYYVTVEAAPYWLHK 338
Query: 145 PQATVGEEGGVARFQCQIHGLPKPLITWEKNRVPID--TDNERYTLLPKGVLQITGLRAE 202
PQ+ + G AR CQ+ G P+P +TW N +P++ +++Y + +G L ++ ++
Sbjct: 339 PQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRI-QRGALILSNVQPS 397
Query: 203 DGGIFHCVASNIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQ--TAVLECV 260
D + C A N HG L ++ + + PA ++ +N T Q TA L C
Sbjct: 398 DTMVTQCEARN------RHG--LLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCK 449
Query: 261 ATGNPRPIVSWSRLDGRPI-GVEGIQVLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRT 319
A G P P V W DG + E G L I D+ +G Y C A V T
Sbjct: 450 AFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNV--T 507
Query: 320 AQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEP--PPHVTWLKNGQVLGP-GGHV 376
L V+ + Q P+S G+ FTCQA +P P +TW +G+ L G
Sbjct: 508 IMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSD 567
Query: 377 RLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAEGLPGP-PRNVRA--V 433
+ + L I + D+ Y CVA ++ A+L V+ G PGP PR V +
Sbjct: 568 KYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVV---GSPGPVPRLVLSDLH 624
Query: 434 SVSSTEVRVSWSEPLANTKEIIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPSTA 493
++ ++VRVSWS + I Y + PE Y L P
Sbjct: 625 LLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVH 684
Query: 494 YSFYIKAYTPRGASSAS-VPTLASTLGEAPAPPPLSVRVLG--SSSLQLLWEP--WPRLA 548
Y+F + A G S V T AP P+ V+ G ++++ + W+P W
Sbjct: 685 YTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWN 744
Query: 549 QHEGGFKLFYRPA------SKTSFTGPILLPGTVSSYNLSQLDPTAVYEVKLLAYNQHGD 602
+ +++ +RP + + P L+ S++ YE+K+ A N G
Sbjct: 745 APQVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTF--------VPYEIKVQAVNSQGK 796
Query: 603 G 603
G
Sbjct: 797 G 797
Score = 114 bits (286), Expect = 3e-25
Identities = 118/434 (27%), Positives = 167/434 (38%), Gaps = 50/434 (11%)
Query: 16 LWPRLLL-PLLLLLLPAPSEGLGHSAELAFAVEPSDD--VAVPGQPIVLDCRVEGTPPVR 72
+WP LL P LL+ +P EG H E E S V P I L C G P V+
Sbjct: 8 VWPLLLCSPCLLIQIPEEYEG-HHVMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQ 66
Query: 73 ITWRKNGVEL-------------PESTHSTLLANGSLMIRHFRLEPGGSPSDEGDYECVA 119
W ++GV P S T+ N S + F +G Y C A
Sbjct: 67 FRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRF----------QGIYRCFA 116
Query: 120 QNRFGLVVSRKARIQAATMSDFHVHPQATVG----EEGGVARFQCQIHGLPKPL-ITWEK 174
N+ G +S + R+ A + P+ TV EEG C +PL I W
Sbjct: 117 SNKLGTAMSHEIRLMAEGAPKW---PKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMN 173
Query: 175 NRVPIDTDNERYTLLPKGVLQITGLRAEDGG---IFHCVASNIASIRISHGARLTVSGSG 231
+++ +ER T+ G L + D I H +I L V +
Sbjct: 174 SKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATN 233
Query: 232 SGAYKEPAILV---GPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEGIQVLG 288
S ++P +L +L Q VLEC+A G P P + W R G P+ + +
Sbjct: 234 SMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSG-PMPADRVTYQN 292
Query: 289 TGNLI-ISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTA 347
+ + V + G Y C A R + V+A ++ PQS G TA
Sbjct: 293 HNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYY--VTVEAAPYWLHKPQSHLYGPGETA 350
Query: 348 MFTCQAQGEPPPHVTWLKNG---QVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAEN 404
CQ QG P P VTW NG + L R++ L +S + P D + QC A N
Sbjct: 351 RLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQ--RGALILSNVQPSDTMVTQCEARN 408
Query: 405 SAGSSQASARLTVL 418
G A+A + V+
Sbjct: 409 RHGLLLANAYIYVV 422
Score = 104 bits (260), Expect = 3e-22
Identities = 142/605 (23%), Positives = 246/605 (40%), Gaps = 80/605 (13%)
Query: 47 EPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPE--STHSTLLANGSLMIRHFRLE 104
+P + PG+ LDC+V+G P +TWR NG+ + E + G+L++ + +
Sbjct: 338 KPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQ-- 395
Query: 105 PGGSPSDEGDYECVAQNRFGLVVSRK----ARIQAATMSDFHVHPQATVGEEGGVARFQC 160
PSD +C A+NR GL+++ ++ A ++ Q + +G A C
Sbjct: 396 ----PSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILT---ADNQTYMAVQGSTAYLLC 448
Query: 161 QIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRIS 220
+ G P P + W +ER+ G L I L+A D G + C+A+N + ++
Sbjct: 449 KAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQN-NVT 507
Query: 221 HGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNP--RPIVSWSRLDGRP 278
A L V + I GP + C A+ +P +P ++W R DGR
Sbjct: 508 IMANLKVKDATQ-------ITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITW-RGDGRD 559
Query: 279 I---GVEGIQVLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAP------ 329
+ G + G L+I + G Y C A+ V AQ LVV +P
Sbjct: 560 LQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQ-LLVVGSPGPVPRL 618
Query: 330 --AEFVQHPQSISRPAGTTA--------MFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLK 379
++ QS R + + A + + + + W G+V G
Sbjct: 619 VLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPG-------- 670
Query: 380 NNNSTLTISGIGPEDEAIYQCVAENSAGSSQAS-ARLTVLWAEGLPGP-PRNVRAVSVSS 437
N T T + P ++ A N G + S TV+ E P P +V+ +
Sbjct: 671 --NQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNET 728
Query: 438 TEVRVSWSEPLA----NTKEIIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPSTA 493
T + ++W +PL N ++ V + P +QE + F +VS+
Sbjct: 729 TNMVITW-KPLRWMDWNAPQVQYRVQWRPQGTRGP---WQEQIVSDPFL-VVSNTSTFVP 783
Query: 494 YSFYIKAYTPRGASSASVPTLASTLGEAP-APPPLS-VRVLGSSSLQLLWEPWPRLAQHE 551
Y ++A +G T+ + + P A P L + +L SS++ + W P LAQ +
Sbjct: 784 YEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVD-LAQVK 842
Query: 552 GGFK----LFYRPASKTSFT------GPILLPGTVSSYNLSQLDPTAVYEVKLLAYNQHG 601
G + ++R S+ + +++P +S LS L P + Y +++ A+N G
Sbjct: 843 GHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRG 902
Query: 602 DGNAT 606
G A+
Sbjct: 903 SGPAS 907
Score = 63.5 bits (153), Expect = 7e-10
Identities = 118/514 (22%), Positives = 190/514 (36%), Gaps = 81/514 (15%)
Query: 48 PSDDVAVPGQPIVLDCRVEGTPPVR--ITWRKNGVELPESTHST--LLANGSLMIRHFRL 103
P + G + C+ P ++ ITWR +G +L E S + +G L+I
Sbjct: 524 PRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDY 583
Query: 104 EPGGSPSDEGDYECVAQNRFGLVVSRKARIQAAT--------MSDFHVHPQATVGEEGGV 155
SD+G+Y CVA +V SR + + +SD H+ Q+ V V
Sbjct: 584 ------SDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVR----V 633
Query: 156 ARFQCQIHGLP--KPLITWE-KNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVAS 212
+ + H P K I +E K P E++ L K T + H
Sbjct: 634 SWSPAEDHNAPIEKYDIEFEDKEMAP-----EKWYSLGKVPGNQTSTTLKLSPYVHYTFR 688
Query: 213 NIASIRISHGARLTVSGS----GSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPI 268
A + G VS + + K P + G N T + V T P
Sbjct: 689 VTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNM--------VITWKPLRW 740
Query: 269 VSWS------RLDGRPIGVEGI---QVLGTGNLIISDV-TVQHSGVYVCAANRPGTRVRR 318
+ W+ R+ RP G G Q++ L++S+ T + V A N G +
Sbjct: 741 MDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQG----K 796
Query: 319 TAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPP-------------HVTWLK 365
+ ++ + E +PQ+I G + + + P +VT+ +
Sbjct: 797 GPEPQVTIGYSGE--DYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWR 854
Query: 366 NGQVLGPG------GHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTVLW 419
G HV + N +++ +SG+ P + A N GS AS T
Sbjct: 855 EGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPAS-EFTFST 913
Query: 420 AEGLPGPPRNVRAVSVSSTEVRVSWSEPLANTKEIIGYVL--HIRKAADPPELEYQEAVS 477
EG+PG P + S+T + + W PL++ + GYVL H +L +
Sbjct: 914 PEGVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGKGQLSF-NLRD 972
Query: 478 KSTFQHLVSDLEPSTAYSFYIKAYTPRGASSASV 511
H ++DL P Y F ++A T G A V
Sbjct: 973 PELRTHNLTDLSPHLRYRFQLQATTKEGPGEAIV 1006
Score = 50.8 bits (120), Expect = 5e-06
Identities = 41/141 (29%), Positives = 64/141 (45%), Gaps = 14/141 (9%)
Query: 476 VSKSTFQHLVSDLEPSTAYSFYIKAYTPRGASSASVPTLASTLGEAPAPPPLSVRVLGSS 535
V +T ++S L P ++Y ++A+ RG+ AS T ++ G P L + ++
Sbjct: 873 VPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFSTPEGVPGHPEALHLECQSNT 932
Query: 536 SLQLLWEPWPRLAQHEG---GFKLFYRP-----ASKTSFTGPILLPGTVSSYNLSQLDPT 587
SL L W+P H G G+ L Y P + SF L + ++NL+ L P
Sbjct: 933 SLLLRWQP---PLSHNGVLTGYVLSYHPLDEGGKGQLSFN---LRDPELRTHNLTDLSPH 986
Query: 588 AVYEVKLLAYNQHGDGNATVR 608
Y +L A + G G A VR
Sbjct: 987 LRYRFQLQATTKEGPGEAIVR 1007
>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
isoform 2 precursor [Homo sapiens]
Length = 1910
Score = 159 bits (402), Expect = 1e-38
Identities = 157/576 (27%), Positives = 230/576 (39%), Gaps = 30/576 (5%)
Query: 44 FAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRL 103
F EP D + V G C+ G P R+TW K G ++ T+ + S R+
Sbjct: 35 FIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGAV-LRI 93
Query: 104 EPGGSPSDEGDYECVAQNRFG-------LVVSRKARIQAATMSDFHVHPQATVGEEGGVA 156
+P +P DE YECVAQN G L V R+ ++ + + + PQ V E A
Sbjct: 94 QPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSG-FPNIDMGPQLKVVERTRTA 152
Query: 157 RFQCQIHGLPKPLITWEKNRVPID--TDNERYTLLPKGVLQITGLRAEDGGIFHCVASNI 214
C G P P ITW K+ +P+D N R L G LQI D G + CVA+N
Sbjct: 153 TMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSEETDQGKYECVATNS 212
Query: 215 ASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRL 274
A +R S A L V P + P + + + CVA G+P P V W +
Sbjct: 213 AGVRYSSPANLYVRVRRVA----PRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQ- 267
Query: 275 DGRPIGVEGIQVLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQ 334
+ E +G L ++DV + S Y C A + AQ + V++ +
Sbjct: 268 GAEDLTPEDDMPVGRNVLELTDV--KDSANYTCVAMSSLGVIEAVAQ--ITVKSLPKAPG 323
Query: 335 HPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTL--TISGIGP 392
P A T++ G P P ++ + G ++K + +T +I G+ P
Sbjct: 324 TPMVTENTA--TSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSP 381
Query: 393 EDEAIYQCVAENSAGSSQASARLTVLWAEGLPGP-PRNVRAVSVSSTEVRVSWSEPLANT 451
E A NS G S + E P PRNV+A +S+T + V W EP+
Sbjct: 382 NSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPN 441
Query: 452 KEIIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKAYTPRGASSASV 511
I GY ++ + P +Q+ + V L Y+ + A+T G S
Sbjct: 442 GLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSD 501
Query: 512 PTLASTLGEAPAPP-PLSVRVLGSSSLQLLWEPWPRLAQHEGGFKLFYRPASKTSFTGPI 570
P T P P L +S+ L W P PR + ++L +R G
Sbjct: 502 PIQVKTQQGVPGQPMNLRAEARSETSITLSWSP-PR-QESIIKYELLFREGDHGREVGRT 559
Query: 571 LLPGTVSSYNLSQLDPTAVYEVKLLAYNQHGDGNAT 606
P T SY + L P Y +L A + G G T
Sbjct: 560 FDPTT--SYVVEDLKPNTEYAFRLAARSPQGLGAFT 593
Score = 116 bits (290), Expect = 1e-25
Identities = 143/573 (24%), Positives = 241/573 (42%), Gaps = 68/573 (11%)
Query: 63 CRVEGTPPVRITWRKNGVEL-PESTHSTL--LANGSLMIRHFRLEPGGSPSDEGDYECVA 119
C G P ITW K+ + + P +++ + L +G+L I +D+G YECVA
Sbjct: 156 CAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIE------SSEETDQGKYECVA 209
Query: 120 QNRFGLVVSRKARIQAATMS---DFHVHPQATVGEEGGVARFQCQIHGLPKPLITWEKNR 176
N G+ S A + F + P + GG C G P P + W +
Sbjct: 210 TNSAGVRYSSPANLYVRVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGA 269
Query: 177 VPIDTDNERYTLLPKG--VLQITGLRAEDGGIFHCVASNIASIRISHGARLTVSGSGSGA 234
+ +++ +P G VL++T ++ D + CVA + + I A++TV
Sbjct: 270 EDLTPEDD----MPVGRNVLELTDVK--DSANYTCVAMSSLGV-IEAVAQITVKSLP--- 319
Query: 235 YKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSW-----SRLDGRPIGVEGIQVLGT 289
K P + EN T++ +GNP P+ + S+ P ++ + + T
Sbjct: 320 -KAPGTPMVTENTA-----TSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIK--EDITT 371
Query: 290 GNLIISDVTVQHS-GVYVCAANRPG------TRVRRTAQGRLVVQAPAEFVQHPQSISRP 342
I ++ ++V A N G + V RT + QAPA ++ Q+
Sbjct: 372 TRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGE-----QAPASAPRNVQARMLS 426
Query: 343 AGTTAMFTCQAQGEPPPHVTWLKNGQVLGP----GGHVRLKNNNSTLTISGIGPEDEAI- 397
A TT + + EP + + + P G + ++S LT G EDE
Sbjct: 427 A-TTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYT 485
Query: 398 YQCVAENSAGSSQASARLTVLWAEGLPGPPRNVRAVSVSSTEVRVSWSEPLANTKEIIGY 457
+ +A S G S + V +G+PG P N+RA + S T + +SWS P + II Y
Sbjct: 486 VRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPP--RQESIIKY 543
Query: 458 VLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKAYTPRGASSASVPTLAST 517
L R+ E+ T ++V DL+P+T Y+F + A +P+G + + T
Sbjct: 544 ELLFREGDHGREVG---RTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRT 600
Query: 518 LGEAPAPPPLSVRVLG--SSSLQLLWEPWPRLAQHEG---GFKLFYRPASKTSFTGPIL- 571
L P+ PP V+ + S+++ + W P P H G G+ + YRP +
Sbjct: 601 LQSKPSAPPQDVKCVSVRSTAILVSWRP-PPPETHNGALVGYSVRYRPLGSEDPEPKEVN 659
Query: 572 -LPGTVSSYNLSQLDPTAVYEVKLLAYNQHGDG 603
+P T + L L+ Y + +A+ + G G
Sbjct: 660 GIPPTTTQILLEALEKWTQYRITTVAHTEVGPG 692
Score = 80.1 bits (196), Expect = 8e-15
Identities = 61/221 (27%), Positives = 101/221 (45%), Gaps = 12/221 (5%)
Query: 401 VAENSAGSSQASARLTVLWAEGLPG-PPRNVRAVSVSSTEVRVSWSEPLANTK--EIIGY 457
VA G S+ + V E +P PPR V A ++++T +RV W P + +I GY
Sbjct: 684 VAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGY 743
Query: 458 VLHI-----RKAADPPELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKAYTPRGASSASVP 512
+H +A PP ++ + + + ++++L+P TAYS + AYT +G + S P
Sbjct: 744 QVHYVRMEGAEARGPPRIK--DVMLADAQEMVITNLQPETAYSITVAAYTMKGDGARSKP 801
Query: 513 TLASTLGEAPAPPPLSVRVLGSSSLQLLWEPWPRLAQHEG-GFKLFYRPASKTSFTGPIL 571
+ T G P LSV+ SL WEP A+ + G++L + T +
Sbjct: 802 KVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPL-ATLE 860
Query: 572 LPGTVSSYNLSQLDPTAVYEVKLLAYNQHGDGNATVRFVSL 612
P + Y S + A Y +L A ++ G G +S+
Sbjct: 861 FPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSI 901
Score = 75.1 bits (183), Expect = 2e-13
Identities = 105/443 (23%), Positives = 173/443 (39%), Gaps = 67/443 (15%)
Query: 231 GSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEGIQVL--- 287
G A + P + P++ A C ATG+P+P V+W++ G+ + + + +
Sbjct: 26 GCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNK-KGKKVNSQRFETIEFD 84
Query: 288 ---GTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVV----QAPAEFV---QHPQ 337
G I T + VY C A + T +L V Q P+ F PQ
Sbjct: 85 ESAGAVLRIQPLRTPRDENVYECVAQNSVGEI--TVHAKLTVLREDQLPSGFPNIDMGPQ 142
Query: 338 SISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGP-GGHVRLKN-NNSTLTISGIGPEDE 395
TA C A G P P +TW K+ + P + R+K + L I D+
Sbjct: 143 LKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSEETDQ 202
Query: 396 AIYQCVAENSAG---SSQASARLTV-----------LWAEGLPGPPRNVRAVSVSSTEVR 441
Y+CVA NSAG SS A+ + V + E +PG N+ V+V S
Sbjct: 203 GKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPY 262
Query: 442 VSWSEPLANTKEIIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKAY 501
V W + A+ E V ++ + ++D++ S Y+ A
Sbjct: 263 VKWMQ-----------------GAEDLTPEDDMPVGRNVLE--LTDVKDSANYT--CVAM 301
Query: 502 TPRGASSASVPTLASTLGEAPAPPPLSVRVLGSSSLQLLWEPWPRLAQHEGGFKLFYRPA 561
+ G A +L +AP P ++ ++S+ + W+ + + +
Sbjct: 302 SSLGVIEAVAQITVKSLPKAPGTPMVTENT--ATSITITWD-----SGNPDPVSYYVIEY 354
Query: 562 SKTSFTGPILLPG--TVSSYNLSQLDPTAVYEVKLLAYNQHGDGNATVRFVSLRGASERT 619
S GP + T + Y++ L P + YE+ + A N G G + V+ G E+
Sbjct: 355 KSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTG--EQA 412
Query: 620 ALSPPCDCRKEEAANQTSTTGIV 642
S P R +A ++TT IV
Sbjct: 413 PASAP---RNVQARMLSATTMIV 432
Score = 73.6 bits (179), Expect = 7e-13
Identities = 63/263 (23%), Positives = 108/263 (41%), Gaps = 16/263 (6%)
Query: 357 PPPHVTWLKNGQVLGPGGHVRLKNNN----STLTISGIGPEDEAIYQCVAENSAGSSQAS 412
PP + +K + G H R ++ + + P E ++ A + G +
Sbjct: 534 PPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFT 593
Query: 413 ARLTVLWAEGLPG-PPRNVRAVSVSSTEVRVSWSEPLANTKE--IIGYVLHIRK-AADPP 468
+ + P PP++V+ VSV ST + VSW P T ++GY + R ++ P
Sbjct: 594 PVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDP 653
Query: 469 ELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKAYTPRGASSASVPTLASTLGEAPAPPPLS 528
E + + +T Q L+ LE T Y A+T G S P + T + P+ PP
Sbjct: 654 EPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRK 713
Query: 529 V--RVLGSSSLQLLWEPWPRLAQHE--GGFKLFYRPASKTSFTGP----ILLPGTVSSYN 580
V L ++++++LW QH G+++ Y GP ++
Sbjct: 714 VEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQEMV 773
Query: 581 LSQLDPTAVYEVKLLAYNQHGDG 603
++ L P Y + + AY GDG
Sbjct: 774 ITNLQPETAYSITVAAYTMKGDG 796
Score = 68.9 bits (167), Expect = 2e-11
Identities = 38/113 (33%), Positives = 56/113 (49%), Gaps = 4/113 (3%)
Query: 322 GRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNN 381
G + P F++ P+ +G A F CQA G+P P VTW K G+ + ++ +
Sbjct: 25 GGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFD 84
Query: 382 NSTLTISGI----GPEDEAIYQCVAENSAGSSQASARLTVLWAEGLPGPPRNV 430
S + I P DE +Y+CVA+NS G A+LTVL + LP N+
Sbjct: 85 ESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNI 137
Score = 46.2 bits (108), Expect = 1e-04
Identities = 44/182 (24%), Positives = 78/182 (42%), Gaps = 15/182 (8%)
Query: 386 TISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAEGLPGPPRNVRAV-SVSSTEVRVSW 444
T SG+ +++ A + G + +A + + + G P+ + A + S+ V + W
Sbjct: 869 TASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRW 928
Query: 445 SEPLANTKE--IIGYVLHIRKAA---DPPELEYQEAVSKSTFQHL-VSDLEPSTAYSFYI 498
P+ + I+ Y + +R+A E E A L + L+P TAY +
Sbjct: 929 LPPVPAERNGAIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQV 988
Query: 499 KAYTPRGASSASVPTLAST-LGEAPAPPPLSVRVLGSSSLQLLWE-------PWPRLAQH 550
+A+T RG S P T L + +P V+++ +S+ L WE P P Q+
Sbjct: 989 RAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQY 1048
Query: 551 EG 552
G
Sbjct: 1049 NG 1050
Score = 37.0 bits (84), Expect = 0.074
Identities = 65/299 (21%), Positives = 105/299 (35%), Gaps = 44/299 (14%)
Query: 323 RLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNN 382
R++ ++PA QH Q M +A+G P L + Q
Sbjct: 725 RVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQ-------------- 770
Query: 383 STLTISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAEGLPGPPRNVRAVSVSST---E 439
+ I+ + PE A G S V+ + G P +SV T
Sbjct: 771 -EMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRP----TLSVQQTPEGS 825
Query: 440 VRVSWSEPLANTKE--IIGYVLHIRKAADPP--ELEYQEAVSKSTFQHLVSDLEPSTAYS 495
+ W EP A T E ++GY L + P LE+ + + T S + Y
Sbjct: 826 LLARW-EPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYT----ASGVHKGATYV 880
Query: 496 FYIKAYTPRGASSASVPTLASTLGEAPAPPPLSVRVLGSSS---LQLLWEPWPRLAQHEG 552
F + A + RG + S + P P + G++S + L W P P A+ G
Sbjct: 881 FRLAARS-RGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLP-PVPAERNG 938
Query: 553 GFKLFYRPASKTSFTGPI--------LLPGTVSSYNLSQLDPTAVYEVKLLAYNQHGDG 603
+ + GP PG ++ L L P Y++++ A+ + G G
Sbjct: 939 AIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPG 997
>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
isoform 3 precursor [Homo sapiens]
Length = 1501
Score = 159 bits (402), Expect = 1e-38
Identities = 157/576 (27%), Positives = 230/576 (39%), Gaps = 30/576 (5%)
Query: 44 FAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRL 103
F EP D + V G C+ G P R+TW K G ++ T+ + S R+
Sbjct: 35 FIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGAV-LRI 93
Query: 104 EPGGSPSDEGDYECVAQNRFG-------LVVSRKARIQAATMSDFHVHPQATVGEEGGVA 156
+P +P DE YECVAQN G L V R+ ++ + + + PQ V E A
Sbjct: 94 QPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSG-FPNIDMGPQLKVVERTRTA 152
Query: 157 RFQCQIHGLPKPLITWEKNRVPID--TDNERYTLLPKGVLQITGLRAEDGGIFHCVASNI 214
C G P P ITW K+ +P+D N R L G LQI D G + CVA+N
Sbjct: 153 TMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSEETDQGKYECVATNS 212
Query: 215 ASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRL 274
A +R S A L V P + P + + + CVA G+P P V W +
Sbjct: 213 AGVRYSSPANLYVRVRRVA----PRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQ- 267
Query: 275 DGRPIGVEGIQVLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQ 334
+ E +G L ++DV + S Y C A + AQ + V++ +
Sbjct: 268 GAEDLTPEDDMPVGRNVLELTDV--KDSANYTCVAMSSLGVIEAVAQ--ITVKSLPKAPG 323
Query: 335 HPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTL--TISGIGP 392
P A T++ G P P ++ + G ++K + +T +I G+ P
Sbjct: 324 TPMVTENTA--TSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSP 381
Query: 393 EDEAIYQCVAENSAGSSQASARLTVLWAEGLPGP-PRNVRAVSVSSTEVRVSWSEPLANT 451
E A NS G S + E P PRNV+A +S+T + V W EP+
Sbjct: 382 NSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPN 441
Query: 452 KEIIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKAYTPRGASSASV 511
I GY ++ + P +Q+ + V L Y+ + A+T G S
Sbjct: 442 GLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSD 501
Query: 512 PTLASTLGEAPAPP-PLSVRVLGSSSLQLLWEPWPRLAQHEGGFKLFYRPASKTSFTGPI 570
P T P P L +S+ L W P PR + ++L +R G
Sbjct: 502 PIQVKTQQGVPGQPMNLRAEARSETSITLSWSP-PR-QESIIKYELLFREGDHGREVGRT 559
Query: 571 LLPGTVSSYNLSQLDPTAVYEVKLLAYNQHGDGNAT 606
P T SY + L P Y +L A + G G T
Sbjct: 560 FDPTT--SYVVEDLKPNTEYAFRLAARSPQGLGAFT 593
Score = 75.1 bits (183), Expect = 2e-13
Identities = 105/443 (23%), Positives = 173/443 (39%), Gaps = 67/443 (15%)
Query: 231 GSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEGIQVL--- 287
G A + P + P++ A C ATG+P+P V+W++ G+ + + + +
Sbjct: 26 GCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNK-KGKKVNSQRFETIEFD 84
Query: 288 ---GTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVV----QAPAEFV---QHPQ 337
G I T + VY C A + T +L V Q P+ F PQ
Sbjct: 85 ESAGAVLRIQPLRTPRDENVYECVAQNSVGEI--TVHAKLTVLREDQLPSGFPNIDMGPQ 142
Query: 338 SISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGP-GGHVRLKN-NNSTLTISGIGPEDE 395
TA C A G P P +TW K+ + P + R+K + L I D+
Sbjct: 143 LKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSEETDQ 202
Query: 396 AIYQCVAENSAG---SSQASARLTV-----------LWAEGLPGPPRNVRAVSVSSTEVR 441
Y+CVA NSAG SS A+ + V + E +PG N+ V+V S
Sbjct: 203 GKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPY 262
Query: 442 VSWSEPLANTKEIIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKAY 501
V W + A+ E V ++ + ++D++ S Y+ A
Sbjct: 263 VKWMQ-----------------GAEDLTPEDDMPVGRNVLE--LTDVKDSANYT--CVAM 301
Query: 502 TPRGASSASVPTLASTLGEAPAPPPLSVRVLGSSSLQLLWEPWPRLAQHEGGFKLFYRPA 561
+ G A +L +AP P ++ ++S+ + W+ + + +
Sbjct: 302 SSLGVIEAVAQITVKSLPKAPGTPMVTENT--ATSITITWD-----SGNPDPVSYYVIEY 354
Query: 562 SKTSFTGPILLPG--TVSSYNLSQLDPTAVYEVKLLAYNQHGDGNATVRFVSLRGASERT 619
S GP + T + Y++ L P + YE+ + A N G G + V+ G E+
Sbjct: 355 KSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTG--EQA 412
Query: 620 ALSPPCDCRKEEAANQTSTTGIV 642
S P R +A ++TT IV
Sbjct: 413 PASAP---RNVQARMLSATTMIV 432
Score = 68.9 bits (167), Expect = 2e-11
Identities = 38/113 (33%), Positives = 56/113 (49%), Gaps = 4/113 (3%)
Query: 322 GRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNN 381
G + P F++ P+ +G A F CQA G+P P VTW K G+ + ++ +
Sbjct: 25 GGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFD 84
Query: 382 NSTLTISGI----GPEDEAIYQCVAENSAGSSQASARLTVLWAEGLPGPPRNV 430
S + I P DE +Y+CVA+NS G A+LTVL + LP N+
Sbjct: 85 ESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNI 137
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform
2 precursor [Homo sapiens]
Length = 1899
Score = 158 bits (400), Expect = 2e-38
Identities = 176/657 (26%), Positives = 266/657 (40%), Gaps = 79/657 (12%)
Query: 19 RLLLPLLLLLLPAPSEGLGHSAELAFAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKN 78
RLLL LL L +E F P D V G C+ G P +I W K
Sbjct: 6 RLLLLLLTFFLRTDAE-----TPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 60
Query: 79 GVELPESTHSTLL---ANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFG-------LVVS 128
G ++ + +GS++ R++P +P DE YECVA N G L V
Sbjct: 61 GKKVSNQRFEVIEFDDGSGSVL----RIQPLRTPRDEAIYECVASNNVGEISVSTRLTVL 116
Query: 129 RKARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGLPKPLITWEKNRVPIDTDNE--RY 186
R+ +I + PQ V E A C G P P ITW K+ +P+DT N R
Sbjct: 117 REDQIPRG-FPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRI 175
Query: 187 TLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLTVSGSGSGAYKEPAILVGPEN 246
L G LQI D G + CVA+N A R S A L V P + P N
Sbjct: 176 KQLRSGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYV----RVRRVPPRFSIPPTN 231
Query: 247 LTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEGIQVLGTGNLIISDVTVQHSGVYV 306
+ + + CVA G+P P V W L + E +G L ++D V+ S Y
Sbjct: 232 HEIMPGGSVNITCVAVGSPMPYVKW-MLGAEDLTPEDDMPIGRNVLELND--VRQSANYT 288
Query: 307 CAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGT--------TAMFTCQAQGEPP 358
C A + G V++A A+ +++ +P GT T++ G P
Sbjct: 289 CVA--------MSTLG--VIEAIAQIT--VKALPKPPGTPVVTESTATSITLTWDSGNPE 336
Query: 359 PHVTWL-----KNGQVLGPGGHVRLKNNNST-LTISGIGPEDEAIYQCVAENSAGSSQAS 412
P ++ KN + L + + +T +++G+ P + ++ VA N+ G S
Sbjct: 337 PVSYYIIQHKPKNSEEL----YKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPS 392
Query: 413 ARLTVLWAEGLP-GPPRNVRAVSVSSTEVRVSWSEPLANTKEIIGYVLHIRKAADPPE-- 469
+ +E P PR+V+A +SST + V W EP +I GY + DP +
Sbjct: 393 EPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGY--RVYYTMDPTQHV 450
Query: 470 ---LEYQEAVSKSTFQHLVSDLEPSTAYSFYIKAYTPRGASSASVPTLASTLGEAPAPPP 526
+++ A S+ T + +L P YS + A+T G S T P P
Sbjct: 451 NNWMKHNVADSQIT---TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPG-QP 506
Query: 527 LSVRVLGSSSLQLLWEPWPRLAQHEGGFKLFYRPASKTSFTGPILLPGTVSSYNLSQLDP 586
L+ + S +L P + ++L Y+ + PGT SY L L P
Sbjct: 507 LNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGT--SYRLQGLKP 564
Query: 587 TAVYEVKLLAYNQHGDGNATVRFVSLRGASERTALSPPCDCRKEEAANQTSTTGIVI 643
++Y +L A + G G +T S RT S P ++ + S+T I++
Sbjct: 565 NSLYYFRLAARSPQGLGASTAEI------SARTMQSKPSAPPQDISCTSPSSTSILV 615
Score = 108 bits (271), Expect = 2e-23
Identities = 146/606 (24%), Positives = 239/606 (39%), Gaps = 69/606 (11%)
Query: 63 CRVEGTPPVRITWRKNGVELPESTHS---TLLANGSLMIRHFRLEPGGSPSDEGDYECVA 119
C G P ITW K+ + + S ++ L +G+L I SD+G YECVA
Sbjct: 147 CAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGALQIEQ------SEESDQGKYECVA 200
Query: 120 QNRFGLVVSRKARIQAATMS---DFHVHPQATVGEEGGVARFQCQIHGLPKPLITWEKNR 176
N G S A + F + P GG C G P P + W
Sbjct: 201 TNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGA 260
Query: 177 VPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLTVSGSGSGAYK 236
+ +++ + + VL++ +R + CVA + + I A++TV K
Sbjct: 261 EDLTPEDDMP--IGRNVLELNDVRQSAN--YTCVAMSTLGV-IEAIAQITVKALP----K 311
Query: 237 EPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEGI--QVLGTGNLII 294
P V E+ ++ T +GNP P VS+ + +P E + ++ G
Sbjct: 312 PPGTPVVTESTATSITLTW-----DSGNPEP-VSYYIIQHKPKNSEELYKEIDGVATTRY 365
Query: 295 SDVTVQHSGVY---VCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRP------AGT 345
S + Y V A N G R V+ +E Q P S R + T
Sbjct: 366 SVAGLSPYSDYEFRVVAVNNIG----RGPPSEPVLTQTSE--QAPSSAPRDVQARMLSST 419
Query: 346 TAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVR--LKNNNSTLTISGIG---PEDEAIYQC 400
T + + EP + + + P HV +K+N + I+ IG P+ +
Sbjct: 420 TILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKV 479
Query: 401 VAENSAGSSQASARLTVLWAEGLPGPPRNVRAVSVSSTEVRVSWSEPLANTKEIIGYVLH 460
+A S G S+ + V+ G+PG P N +A S T + +SW+ P ++T I Y L
Sbjct: 480 LAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDT--IANYELV 537
Query: 461 IRKAADPPELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKAYTPRGASSASVPTLASTLGE 520
+ D E Q + + + L+P++ Y F + A +P+G +++ A T+
Sbjct: 538 YK---DGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQS 594
Query: 521 APAPPPLSVRVLGSSSLQLL--WEPWPRLAQHEGGFKLFYRPASKTSFTGP-------IL 571
P+ PP + SS +L W+P P + + G Y T+ G +
Sbjct: 595 KPSAPPQDISCTSPSSTSILVSWQPPP--VEKQNGIITEY-SIKYTAVDGEDDKPHEILG 651
Query: 572 LPGTVSSYNLSQLDPTAVYEVKLLAYNQHGDGNATVRFVSLRGASERTALSPPCDCRKEE 631
+P + Y L QL+ Y + + A+ G G ++ L +E PP + E
Sbjct: 652 IPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSV--LIRTNEDVPSGPPRKV-EVE 708
Query: 632 AANQTS 637
A N TS
Sbjct: 709 AVNSTS 714
Score = 75.1 bits (183), Expect = 2e-13
Identities = 61/226 (26%), Positives = 98/226 (43%), Gaps = 16/226 (7%)
Query: 402 AENSAGSSQASARLTVLWAEGLP-GPPRNVRAVSVSSTEVRVSWSEPLANTK--EIIGYV 458
A G S + + E +P GPPR V +V+ST V+VSW P+ N + +I GY
Sbjct: 676 AHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQ 735
Query: 459 LH-IRKAADPPE---------LEYQEAVSKSTFQH--LVSDLEPSTAYSFYIKAYTPRGA 506
+H +R P+ L + T +H ++S L+P T+YS + AYT +G
Sbjct: 736 VHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGD 795
Query: 507 SSASVPTLASTLGEAPAPPPLSVRVLGSSSLQLLWEPWPRLAQHEGGFKLFYRPASKTSF 566
+ S P L ST G P P L + ++ + W P G++L +
Sbjct: 796 GARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPL 855
Query: 567 TGPILLPGTVSSYNLSQLDPTAVYEVKLLAYNQHGDGNATVRFVSL 612
T + + + + A Y +L A N+ G G V+ +S+
Sbjct: 856 T-TLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISI 900
Score = 57.0 bits (136), Expect = 7e-08
Identities = 64/237 (27%), Positives = 100/237 (42%), Gaps = 16/237 (6%)
Query: 385 LTISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAEGLPGPPRNVRAVSVSSTEVRVSW 444
+ ISG+ PE A + G S V +PG PR V + +T + + W
Sbjct: 772 MIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTAL-IQW 830
Query: 445 SEPLANTKEIIGYVLHI-RKAADP-PELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKAYT 502
P+ + GY L RK +P LE+ E T +D+ +Y F + A
Sbjct: 831 HPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFT----ATDIHKGASYVFRLSARN 886
Query: 503 PRGASSASVPTLASTLGEAPAPPPLSVRVLG--SSSLQLLWEPWPRLAQHEG---GFKLF 557
G V + S E P P ++ G S+S+QL W+P P LA+ G + L
Sbjct: 887 KVGFGEEMVKEI-SIPEEVPTGFPQNLHSEGTTSTSVQLSWQP-PVLAERNGIITKYTLL 944
Query: 558 YRPASKTSFTGPILLPGTVSSYNLSQLDPTAVYEVKLLAYNQHGDG--NATVRFVSL 612
YR + L+ ++ L+ L P Y+VK+ A+ G G + +V+F +L
Sbjct: 945 YRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTL 1001
Score = 44.7 bits (104), Expect = 4e-04
Identities = 34/148 (22%), Positives = 65/148 (43%), Gaps = 2/148 (1%)
Query: 397 IYQCVAENSAGSSQASARLTVLWAEGLPGPPRNVRAVSVSSTEVRVSWSEP-LANTKEII 455
+++ A N G + + + E G P+N+ + +ST V++SW P LA II
Sbjct: 879 VFRLSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGII 938
Query: 456 GYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKAYTPRGASSASVPTLA 515
+ + + P L ++ + + ++ L+P T Y ++A+T +G S
Sbjct: 939 TKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQF 998
Query: 516 STLG-EAPAPPPLSVRVLGSSSLQLLWE 542
TL + V+ + +S+ L WE
Sbjct: 999 RTLPVDQVFAKNFHVKAVMKTSVLLSWE 1026
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,021,715
Number of Sequences: 37866
Number of extensions: 2053088
Number of successful extensions: 18173
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 296
Number of HSP's successfully gapped in prelim test: 390
Number of HSP's that attempted gapping in prelim test: 9387
Number of HSP's gapped (non-prelim): 4294
length of query: 814
length of database: 18,247,518
effective HSP length: 111
effective length of query: 703
effective length of database: 14,044,392
effective search space: 9873207576
effective search space used: 9873207576
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.