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Search of human proteins with 55741473
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin
protein ligase 2 [Homo sapiens]
(1572 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin prote... 3177 0.0
gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens] 1675 0.0
gi|114520609 neural precursor cell expressed, developmentally do... 454 e-127
gi|114520607 neural precursor cell expressed, developmentally do... 454 e-127
gi|21361472 neural precursor cell expressed, developmentally dow... 430 e-120
gi|222352094 neural precursor cell expressed, developmentally do... 430 e-120
gi|222352092 neural precursor cell expressed, developmentally do... 430 e-120
gi|222352090 neural precursor cell expressed, developmentally do... 430 e-120
gi|222352183 neural precursor cell expressed, developmentally do... 400 e-111
gi|222352088 neural precursor cell expressed, developmentally do... 400 e-111
gi|222352086 neural precursor cell expressed, developmentally do... 400 e-111
gi|222352084 neural precursor cell expressed, developmentally do... 400 e-111
gi|222352082 neural precursor cell expressed, developmentally do... 400 e-111
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i... 379 e-104
gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [... 377 e-104
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi... 374 e-103
gi|40806211 WW domain containing E3 ubiquitin protein ligase 2 i... 363 e-100
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa... 363 e-100
gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [H... 360 5e-99
gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H... 360 5e-99
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens] 310 9e-84
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu... 265 3e-70
gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens] 190 8e-48
gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens] 190 8e-48
gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens] 190 8e-48
gi|7657152 hect domain and RLD 3 [Homo sapiens] 183 1e-45
gi|190341084 HECT domain containing 2 isoform a [Homo sapiens] 183 1e-45
gi|35493952 ubiquitin protein ligase E3B [Homo sapiens] 182 3e-45
gi|35493959 ubiquitin protein ligase E3B [Homo sapiens] 182 3e-45
gi|87116668 hypothetical protein LOC9870 [Homo sapiens] 180 8e-45
>gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin protein
ligase 2 [Homo sapiens]
Length = 1572
Score = 3177 bits (8237), Expect = 0.0
Identities = 1572/1572 (100%), Positives = 1572/1572 (100%)
Query: 1 MASSAREHLLFVRRRNPQMRYTLSPENLQSLAAQSSMPENMTLQRANSDTDLVTSESRSS 60
MASSAREHLLFVRRRNPQMRYTLSPENLQSLAAQSSMPENMTLQRANSDTDLVTSESRSS
Sbjct: 1 MASSAREHLLFVRRRNPQMRYTLSPENLQSLAAQSSMPENMTLQRANSDTDLVTSESRSS 60
Query: 61 LTASMYEYTLGQAQNLIIFWDIKEEVDPSDWIGLYHIDENSPANFWDSKNRGVTGTQKGQ 120
LTASMYEYTLGQAQNLIIFWDIKEEVDPSDWIGLYHIDENSPANFWDSKNRGVTGTQKGQ
Sbjct: 61 LTASMYEYTLGQAQNLIIFWDIKEEVDPSDWIGLYHIDENSPANFWDSKNRGVTGTQKGQ 120
Query: 121 IVWRIEPGPYFMEPEIKICFKYYHGISGALRATTPCITVKNPAVMMGAEGMEGGASGNLH 180
IVWRIEPGPYFMEPEIKICFKYYHGISGALRATTPCITVKNPAVMMGAEGMEGGASGNLH
Sbjct: 121 IVWRIEPGPYFMEPEIKICFKYYHGISGALRATTPCITVKNPAVMMGAEGMEGGASGNLH 180
Query: 181 SRKLVSFTLSDLRAVGLKKGMFFNPDPYLKMSIQPGKKSSFPTCAHHGQERRSTIISNTT 240
SRKLVSFTLSDLRAVGLKKGMFFNPDPYLKMSIQPGKKSSFPTCAHHGQERRSTIISNTT
Sbjct: 181 SRKLVSFTLSDLRAVGLKKGMFFNPDPYLKMSIQPGKKSSFPTCAHHGQERRSTIISNTT 240
Query: 241 NPIWHREKYSFFALLTDVLEIEIKDKFAKSRPIIKRFLGKLTIPVQRLLERQAIGDQMLS 300
NPIWHREKYSFFALLTDVLEIEIKDKFAKSRPIIKRFLGKLTIPVQRLLERQAIGDQMLS
Sbjct: 241 NPIWHREKYSFFALLTDVLEIEIKDKFAKSRPIIKRFLGKLTIPVQRLLERQAIGDQMLS 300
Query: 301 YNLGRRLPADHVSGYLQFKVEVTSSVHEDASPEAVGTILGVNSVNGDLGSPSDDEDMPGS 360
YNLGRRLPADHVSGYLQFKVEVTSSVHEDASPEAVGTILGVNSVNGDLGSPSDDEDMPGS
Sbjct: 301 YNLGRRLPADHVSGYLQFKVEVTSSVHEDASPEAVGTILGVNSVNGDLGSPSDDEDMPGS 360
Query: 361 HHDSQVCSNGPVSEDSAADGTPKHSFRTSSTLEIDTEELTSTSSRTSPPRGRQDSLNDYL 420
HHDSQVCSNGPVSEDSAADGTPKHSFRTSSTLEIDTEELTSTSSRTSPPRGRQDSLNDYL
Sbjct: 361 HHDSQVCSNGPVSEDSAADGTPKHSFRTSSTLEIDTEELTSTSSRTSPPRGRQDSLNDYL 420
Query: 421 DAIEHNGHSRPGTATCSERSMGASPKLRSSFPTDTRLNAMLHIDSDEEDHEFQQDLGYPS 480
DAIEHNGHSRPGTATCSERSMGASPKLRSSFPTDTRLNAMLHIDSDEEDHEFQQDLGYPS
Sbjct: 421 DAIEHNGHSRPGTATCSERSMGASPKLRSSFPTDTRLNAMLHIDSDEEDHEFQQDLGYPS 480
Query: 481 SLEEEGGLIMFSRASRADDGSLTSQTKLEDNPVENEEASTHEAASFEDKPENLPELAESS 540
SLEEEGGLIMFSRASRADDGSLTSQTKLEDNPVENEEASTHEAASFEDKPENLPELAESS
Sbjct: 481 SLEEEGGLIMFSRASRADDGSLTSQTKLEDNPVENEEASTHEAASFEDKPENLPELAESS 540
Query: 541 LPAGPAPEEGEGGPEPQPSADQGSAELCGSQEVDQPTSGADTGTSDASGGSRRAVSETES 600
LPAGPAPEEGEGGPEPQPSADQGSAELCGSQEVDQPTSGADTGTSDASGGSRRAVSETES
Sbjct: 541 LPAGPAPEEGEGGPEPQPSADQGSAELCGSQEVDQPTSGADTGTSDASGGSRRAVSETES 600
Query: 601 LDQGSEPSQVSSETEPSDPARTESVSEASTRPEGESDLECADSSCNESVTTQLSSVDTRC 660
LDQGSEPSQVSSETEPSDPARTESVSEASTRPEGESDLECADSSCNESVTTQLSSVDTRC
Sbjct: 601 LDQGSEPSQVSSETEPSDPARTESVSEASTRPEGESDLECADSSCNESVTTQLSSVDTRC 660
Query: 661 SSLESARFPETPAFSSQEEEDGACAAEPTSSGPAEGSQESVCTAGSLPVVQVPSGEDEGP 720
SSLESARFPETPAFSSQEEEDGACAAEPTSSGPAEGSQESVCTAGSLPVVQVPSGEDEGP
Sbjct: 661 SSLESARFPETPAFSSQEEEDGACAAEPTSSGPAEGSQESVCTAGSLPVVQVPSGEDEGP 720
Query: 721 GAESATVPDQEELGEVWQRRGSLEGAAAAAESPPQEEGSAGEAQGTCEGATAQEEGATGG 780
GAESATVPDQEELGEVWQRRGSLEGAAAAAESPPQEEGSAGEAQGTCEGATAQEEGATGG
Sbjct: 721 GAESATVPDQEELGEVWQRRGSLEGAAAAAESPPQEEGSAGEAQGTCEGATAQEEGATGG 780
Query: 781 SQANGHQPLRSLPSVRQDVSRYQRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTA 840
SQANGHQPLRSLPSVRQDVSRYQRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTA
Sbjct: 781 SQANGHQPLRSLPSVRQDVSRYQRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTA 840
Query: 841 PPAPQVLQRSNSIQQMEQLNRRYQSIRRTMTNERPEENTNAIDGAGEEADFHQASADFRR 900
PPAPQVLQRSNSIQQMEQLNRRYQSIRRTMTNERPEENTNAIDGAGEEADFHQASADFRR
Sbjct: 841 PPAPQVLQRSNSIQQMEQLNRRYQSIRRTMTNERPEENTNAIDGAGEEADFHQASADFRR 900
Query: 901 ENILPHSTSRSRITLLLQSPPVKFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRD 960
ENILPHSTSRSRITLLLQSPPVKFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRD
Sbjct: 901 ENILPHSTSRSRITLLLQSPPVKFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRD 960
Query: 961 THHFERYQHNRDLVGFLNMFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPL 1020
THHFERYQHNRDLVGFLNMFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPL
Sbjct: 961 THHFERYQHNRDLVGFLNMFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPL 1020
Query: 1021 QSSRPTSALVHRQHLTRQRSHSAGEVGEDSRHAGPPVLPRPSSTFNTVSRPQYQDMVPVA 1080
QSSRPTSALVHRQHLTRQRSHSAGEVGEDSRHAGPPVLPRPSSTFNTVSRPQYQDMVPVA
Sbjct: 1021 QSSRPTSALVHRQHLTRQRSHSAGEVGEDSRHAGPPVLPRPSSTFNTVSRPQYQDMVPVA 1080
Query: 1081 YNDKIVAFLRQPNIFEILQERQPDLTRNHSLREKIQFIRTEGTPGLVRLSSDADLVMLLS 1140
YNDKIVAFLRQPNIFEILQERQPDLTRNHSLREKIQFIRTEGTPGLVRLSSDADLVMLLS
Sbjct: 1081 YNDKIVAFLRQPNIFEILQERQPDLTRNHSLREKIQFIRTEGTPGLVRLSSDADLVMLLS 1140
Query: 1141 LFEEEIMSYVPPHALLHPSYCQSPRGSPVSSPQNSPGTQRANARAPAPYKRDFEAKLRNF 1200
LFEEEIMSYVPPHALLHPSYCQSPRGSPVSSPQNSPGTQRANARAPAPYKRDFEAKLRNF
Sbjct: 1141 LFEEEIMSYVPPHALLHPSYCQSPRGSPVSSPQNSPGTQRANARAPAPYKRDFEAKLRNF 1200
Query: 1201 YRKLETKGYGQGPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSG 1260
YRKLETKGYGQGPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSG
Sbjct: 1201 YRKLETKGYGQGPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSG 1260
Query: 1261 PSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIH 1320
PSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIH
Sbjct: 1261 PSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIH 1320
Query: 1321 QYLLDAFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDNDIHDILDLTFTVNEEVF 1380
QYLLDAFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDNDIHDILDLTFTVNEEVF
Sbjct: 1321 QYLLDAFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDNDIHDILDLTFTVNEEVF 1380
Query: 1381 GQITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSV 1440
GQITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSV
Sbjct: 1381 GQITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSV 1440
Query: 1441 FDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFV 1500
FDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFV
Sbjct: 1441 FDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFV 1500
Query: 1501 TGTSSIPYEGFASLRGSNGPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLL 1560
TGTSSIPYEGFASLRGSNGPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLL
Sbjct: 1501 TGTSSIPYEGFASLRGSNGPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLL 1560
Query: 1561 TAVEETSTFGLE 1572
TAVEETSTFGLE
Sbjct: 1561 TAVEETSTFGLE 1572
>gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens]
Length = 1606
Score = 1675 bits (4339), Expect = 0.0
Identities = 928/1659 (55%), Positives = 1103/1659 (66%), Gaps = 161/1659 (9%)
Query: 1 MASSAREHLLFVRRRNPQMRYTLSPENLQSLAAQSSMPENMTLQRANSDTDLVTSESRSS 60
MAS +R R + P +RY+ +P+ ++ + + +T+ R+ SDTDLVTS+SRS+
Sbjct: 22 MASPSRNSQSRRRCKEP-LRYSYNPDQFHNMDLRGGPHDGVTIPRSTSDTDLVTSDSRST 80
Query: 61 LTASMYEYTLGQAQNLIIFWDIKEEVDPSDWIGLYHIDENSPANFWDSKNRGVTGTQKGQ 120
L S Y++G +Q+L+I WDIKEEVD DWIG+Y IDE NF D KNRGV G+ +GQ
Sbjct: 81 LMVSSSYYSIGHSQDLVIHWDIKEEVDAGDWIGMYLIDEVLSENFLDYKNRGVNGSHRGQ 140
Query: 121 IVWRIEPGPYFMEPEIKICFKYYHGISGALRATTPCITVKNPAV----MMGAEGMEGGAS 176
I+W+I+ YF+EPE KICFKYYHG+SGALRATTP +TVKN A +GA+ G
Sbjct: 141 IIWKIDASSYFVEPETKICFKYYHGVSGALRATTPSVTVKNSAAPIFKSIGADETVQGQG 200
Query: 177 GNLHSRKLVSFTLSDLRAVGLKKGMFFNPDPYLKMSIQPGKKSSFPTCAHHGQERRSTII 236
SR+L+SF+LSD +A+GLKKGMFFNPDPYLK+SIQPGK S FP HHGQERRS II
Sbjct: 201 ----SRRLISFSLSDFQAMGLKKGMFFNPDPYLKISIQPGKHSIFPALPHHGQERRSKII 256
Query: 237 SNTTNPIWHREKYSFFALLTDVLEIEIKDKFAKSRPIIKRFLGKLTIPVQRLLERQAIGD 296
NT NPIW E++SF +L TDVLEIE+KDKFAKSRPIIKRFLGKL++PVQRLLER AIGD
Sbjct: 257 GNTVNPIWQAEQFSFVSLPTDVLEIEVKDKFAKSRPIIKRFLGKLSMPVQRLLERHAIGD 316
Query: 297 QMLSYNLGRRLPADHVSGYLQFKVEVTSSVHEDASPEAVGT----ILGVNSVNGDLGSPS 352
+++SY LGRRLP DHVSG LQF+ E+TSS+H D ++ T +S +L
Sbjct: 317 RVVSYTLGRRLPTDHVSGQLQFRFEITSSIHPDDEEISLSTEPESAQIQDSPMNNLMESG 376
Query: 353 DDEDMPGSHHDSQVCSNGPVSEDSAADGTPKHSFRTSSTLE---IDTE------------ 397
E + S+ + E S DG S S E + TE
Sbjct: 377 SGEPRSEAPESSESWKPEQLGEGSVPDGPGNQSIELSRPAEEAAVITEAGDQGMVSVGPE 436
Query: 398 ---ELTSTSSRTSPPRGRQDSLNDYLDAIEHNGHSRPGTATCSERSMGASPKLRSSFPTD 454
EL + + P + L + LD E A+ G +P P +
Sbjct: 437 GAGELLAQVQKDIQPAPSAEELAEQLDLGEE--------ASALLLEDGEAPASTKEEPLE 488
Query: 455 TRLNAMLHIDSDEEDHEFQQDLGYPSSLEEEGGLIMFSRASRADDGSLTSQTKLEDNPVE 514
+EE+ E Q++ G S+LE+ G + S+ +++ PV
Sbjct: 489 EEATTQSRAGREEEEKE-QEEEGDVSTLEQGEGRLQLR-------ASVKRKSRPCSLPVS 540
Query: 515 NEEASTHEAASFEDKPEN----LPELAES--SLPAGPAPEEGEGGPEPQPSADQGSAELC 568
E A + P + L S S G A EE +G E D S+E
Sbjct: 541 ELETVIASACGDPETPRTHYIRIHTLLHSMPSAQGGSAAEEEDGAEEESTLKD--SSEKD 598
Query: 569 GSQEVD-------------QPTSGADTGTSDA--SGGSRRAVSETESLDQGSEPSQVSSE 613
G EVD + GA GT+ SGG +++ + D + PS
Sbjct: 599 GLSEVDTVAADPSALEEDREEPEGATPGTAHPGHSGGHFPSLANGAAQDGDTHPS----- 653
Query: 614 TEPSDPARTESVSEASTRPEGESDLECADSSCNESVTTQLSSVDTRC------------- 660
T S S++S R G+ E D+SC S T C
Sbjct: 654 --------TGSESDSSPRQGGDHSCEGCDASCCSPSCYSSSCYSTSCYSSSCYSASCYSP 705
Query: 661 --------------SSLESARFPETPAFSSQEEEDGACAAEPTSSGPAEGSQESVCTAGS 706
SS++SA+ E+ FSSQ++E+ +A ESV +
Sbjct: 706 SCYNGNRFASHTRFSSVDSAKISESTVFSSQDDEEEENSAF-----------ESVPDSMQ 754
Query: 707 LPVVQVPSGEDEGPGAESATVPDQEELGEVWQRRGSLEGAAAAAESPPQEEGSAGEAQGT 766
P + S GP + P G +E + ESP G + +G
Sbjct: 755 SPELDPESTNGAGPWQDELAAPS-----------GHVERSPEGLESPVA--GPSNRREGE 801
Query: 767 CEGATAQEEGATGGSQANGHQPLRSLPSVRQDVSRYQRVDEALPPNWEARIDSHGRIFYV 826
C + QP+ LPS+R + Y +DE LPPNWEARIDSHGR+FYV
Sbjct: 802 CP-------------ILHNSQPVSQLPSLRPEHHHYPTIDEPLPPNWEARIDSHGRVFYV 848
Query: 827 DHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLNRRYQSIRRTMTNERPEENTNAID--- 883
DHVNRTTTWQRPTA P ++RS SIQQMEQLNRRYQ+I+RT+ ER EE++ +
Sbjct: 849 DHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRTIATERSEEDSGSQSCEQ 908
Query: 884 ---------GAGEEADFHQASADFRRENILPHSTSRSRITLLLQSPPVKFLISPEFFTVL 934
G+ EA+ Q+S D RRE L S+ +ITLLLQSP VKF+ +PEFFTVL
Sbjct: 909 APAGGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQ-KITLLLQSPAVKFITNPEFFTVL 967
Query: 935 HSNPSAYRMFTNNTCLKHMITKVRRDTHHFERYQHNRDLVGFLNMFANKQLELPRGWEMK 994
H+N SAYR+FT++TCLKHMI KVRRD +FERYQHNRDLV F+NMFA+ +LELPRGWE+K
Sbjct: 968 HANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLELPRGWEIK 1027
Query: 995 HDHQGKAFFVDHNSRTTTFIDPRLPLQSSRPTSALVHRQHLTRQRSHSAGEVGEDSRHAG 1054
D QGK+FFVDHNSR TTFIDPR+PLQ+ R + L HRQHL R RS+SAGE E SR+ G
Sbjct: 1028 TDQQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEASEVSRNRG 1087
Query: 1055 PPVLPRPSSTFNTVSRPQYQ-DMVPVAYNDKIVAFLRQPNIFEILQERQPDLTRNHSLRE 1113
+L RP + R Q+Q + +P+AYNDKIVAFLRQPNIFE+LQERQP L RNH+LRE
Sbjct: 1088 ASLLARPGHSLVAAIRSQHQHESLPLAYNDKIVAFLRQPNIFEMLQERQPSLARNHTLRE 1147
Query: 1114 KIQFIRTEGTPGLVRLSSDADLVMLLSLFEEEIMSYVPPHALLHPSYCQSPRGSPVSSPQ 1173
KI +IRTEG GL +LS DADLV+LLSLFEEEIMSYVP A HP Y SPR SP SSPQ
Sbjct: 1148 KIHYIRTEGNHGLEKLSCDADLVILLSLFEEEIMSYVPLQAAFHPGYSFSPRCSPCSSPQ 1207
Query: 1174 NSPGTQRANARAPAPYKRDFEAKLRNFYRKLETKGYGQGPGKLKLIIRRDHLLEDAFNQI 1233
NSPG QRA+ARAP+PY+RDFEAKLRNFYRKLE KG+GQGPGK+KLIIRRDHLLE FNQ+
Sbjct: 1208 NSPGLQRASARAPSPYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQV 1267
Query: 1234 MGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQI 1293
M YSRK+LQRNKLYVTFVGEEGLDYSGPSREFFFL+S+ELFNPYYGLFEYSANDTYTVQI
Sbjct: 1268 MAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQI 1327
Query: 1294 SPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRILCDLSDLEYLDEEF 1353
SPMSAFV+NH EWFRFSGRILGLALIHQYLLDAFFTRPFYKALLR+ CDLSDLEYLDEEF
Sbjct: 1328 SPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEF 1387
Query: 1354 HQSLQWMKDNDIHDILDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIERMVKWR 1413
HQSLQWMKDN+I DILDLTFTVNEEVFGQ+TERELK GGAN VTEKNKKEYIERMVKWR
Sbjct: 1388 HQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWR 1447
Query: 1414 IERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHD 1473
+ERGVVQQTE+LVRGFYEVVD+RLVSVFDARELELVIAGTAEIDL+DWRNNTEYRGGYHD
Sbjct: 1448 VERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHD 1507
Query: 1474 NHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPRRFCVEKWGKITA 1533
H+VIRWFWAAVERFNNEQRLRLLQFVTGTSS+PYEGFA+LRGSNG RRFC+EKWGKIT+
Sbjct: 1508 GHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITS 1567
Query: 1534 LPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGLE 1572
LPRAHTCFNRLDLPPYPS+SMLYEKLLTAVEETSTFGLE
Sbjct: 1568 LPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE 1606
>gi|114520609 neural precursor cell expressed, developmentally
down-regulated 4 isoform 1 [Homo sapiens]
Length = 900
Score = 454 bits (1167), Expect = e-127
Identities = 282/771 (36%), Positives = 400/771 (51%), Gaps = 65/771 (8%)
Query: 803 QRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLNRR 862
Q+ LPP WE R D GR +YV+H +R T W+RPT PQ +++ E N +
Sbjct: 187 QQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPT----PQ-----DNLTDAENGNIQ 237
Query: 863 YQSIRRTMTNERPEENTNAIDGAGEEADFHQASADFRRENILPHSTSRSRITLLLQSPPV 922
Q+ R T + E T ++D ++ D +T S PP
Sbjct: 238 LQAQRAFTTRRQISEETESVDNRESSENWEIIRED--------EATMYSN-QAFPSPPPS 288
Query: 923 KFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHHFERYQHNRDLVGFLNMFAN 982
L P T L +A N+ + + + + + L +
Sbjct: 289 SNLDVP---THLAEELNARLTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLP 345
Query: 983 KQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPLQSSRPTSALVHRQHLTRQRSHS 1042
LP GWE K D +G++++VDHNSRTTT+ P + A V LT +S
Sbjct: 346 TSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTV--------QATVETSQLTSSQSS- 396
Query: 1043 AGEVGEDSRHAGPPVLPRPSSTFNTVSRPQY--QDMVPVAYNDKIVAFLRQPNIFEILQE 1100
AGP S + V++P Q +P + + PN +
Sbjct: 397 ----------AGPQSQASTSDSGQQVTQPSEIEQGFLPKGWEVR-----HAPNGRPFFID 441
Query: 1101 RQPDLTRNHSLREKIQFIRTEGTPGLVRLSSDADLVMLLSLFEEEIMSYVPPHALLHPSY 1160
T R KI G L + DL L +EE + + H
Sbjct: 442 HNTKTTTWEDPRLKIP----AHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYINH--- 494
Query: 1161 CQSPRGSPVSSPQNSPGTQRANARAPA-PYKRDFEAKLRNFYRKLETKGYGQGPGKLKLI 1219
+ + P + PA PY RD++ K F RKL K P K ++
Sbjct: 495 ------NIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKL--KKQNDIPNKFEMK 546
Query: 1220 IRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYG 1279
+RR +LED++ +IMG R D + +L++ F GE+GLDY G +RE+FFL+S+E+FNPYYG
Sbjct: 547 LRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYG 606
Query: 1280 LFEYSANDTYTVQISPMSAFVDNHH-EWFRFSGRILGLALIHQYLLDAFFTRPFYKALLR 1338
LFEYSA D YT+QI+P S + H +F+F GR+ G+A+ H LLD FF RPFYK +L
Sbjct: 607 LFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLH 666
Query: 1339 ILCDLSDLEYLDEEFHQSLQWMKDNDIHDILDLTFTVNEEVFGQITERELKPGGANIPVT 1398
L D+E +D E++ SL+W+ +ND + LDL F ++EE+FGQ + ELK GG+ I VT
Sbjct: 667 KPITLHDMESVDSEYYNSLRWILENDPTE-LDLRFIIDEELFGQTHQHELKNGGSEIVVT 725
Query: 1399 EKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDL 1458
KNKKEYI +++WR + +Q + GF+E++ L+ +FD ELEL++ G ++D+
Sbjct: 726 NKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDV 785
Query: 1459 SDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSN 1518
+DWR +T+Y+ GY NH VI+WFW AV ++E+R+RLLQFVTGTS +P GFA L GSN
Sbjct: 786 NDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSN 845
Query: 1519 GPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTF 1569
GP+ F VE+WG LPRAHTCFNRLDLPPY SF L++KL A+E T F
Sbjct: 846 GPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGF 896
Score = 46.6 bits (109), Expect = 2e-04
Identities = 23/70 (32%), Positives = 35/70 (50%), Gaps = 1/70 (1%)
Query: 770 ATAQEEGATGGSQANGHQPLRSLPSVRQDVSRYQRVDEA-LPPNWEARIDSHGRIFYVDH 828
AT + T + G Q S Q V++ +++ LP WE R +GR F++DH
Sbjct: 383 ATVETSQLTSSQSSAGPQSQASTSDSGQQVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDH 442
Query: 829 VNRTTTWQRP 838
+TTTW+ P
Sbjct: 443 NTKTTTWEDP 452
>gi|114520607 neural precursor cell expressed, developmentally
down-regulated 4 isoform 2 [Homo sapiens]
Length = 1247
Score = 454 bits (1167), Expect = e-127
Identities = 282/771 (36%), Positives = 400/771 (51%), Gaps = 65/771 (8%)
Query: 803 QRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLNRR 862
Q+ LPP WE R D GR +YV+H +R T W+RPT PQ +++ E N +
Sbjct: 534 QQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPT----PQ-----DNLTDAENGNIQ 584
Query: 863 YQSIRRTMTNERPEENTNAIDGAGEEADFHQASADFRRENILPHSTSRSRITLLLQSPPV 922
Q+ R T + E T ++D ++ D +T S PP
Sbjct: 585 LQAQRAFTTRRQISEETESVDNRESSENWEIIRED--------EATMYSN-QAFPSPPPS 635
Query: 923 KFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHHFERYQHNRDLVGFLNMFAN 982
L P T L +A N+ + + + + + L +
Sbjct: 636 SNLDVP---THLAEELNARLTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLP 692
Query: 983 KQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPLQSSRPTSALVHRQHLTRQRSHS 1042
LP GWE K D +G++++VDHNSRTTT+ P + A V LT +S
Sbjct: 693 TSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTV--------QATVETSQLTSSQSS- 743
Query: 1043 AGEVGEDSRHAGPPVLPRPSSTFNTVSRPQY--QDMVPVAYNDKIVAFLRQPNIFEILQE 1100
AGP S + V++P Q +P + + PN +
Sbjct: 744 ----------AGPQSQASTSDSGQQVTQPSEIEQGFLPKGWEVR-----HAPNGRPFFID 788
Query: 1101 RQPDLTRNHSLREKIQFIRTEGTPGLVRLSSDADLVMLLSLFEEEIMSYVPPHALLHPSY 1160
T R KI G L + DL L +EE + + H
Sbjct: 789 HNTKTTTWEDPRLKIP----AHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYINH--- 841
Query: 1161 CQSPRGSPVSSPQNSPGTQRANARAPA-PYKRDFEAKLRNFYRKLETKGYGQGPGKLKLI 1219
+ + P + PA PY RD++ K F RKL K P K ++
Sbjct: 842 ------NIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKL--KKQNDIPNKFEMK 893
Query: 1220 IRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYG 1279
+RR +LED++ +IMG R D + +L++ F GE+GLDY G +RE+FFL+S+E+FNPYYG
Sbjct: 894 LRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYG 953
Query: 1280 LFEYSANDTYTVQISPMSAFVDNHH-EWFRFSGRILGLALIHQYLLDAFFTRPFYKALLR 1338
LFEYSA D YT+QI+P S + H +F+F GR+ G+A+ H LLD FF RPFYK +L
Sbjct: 954 LFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLH 1013
Query: 1339 ILCDLSDLEYLDEEFHQSLQWMKDNDIHDILDLTFTVNEEVFGQITERELKPGGANIPVT 1398
L D+E +D E++ SL+W+ +ND + LDL F ++EE+FGQ + ELK GG+ I VT
Sbjct: 1014 KPITLHDMESVDSEYYNSLRWILENDPTE-LDLRFIIDEELFGQTHQHELKNGGSEIVVT 1072
Query: 1399 EKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDL 1458
KNKKEYI +++WR + +Q + GF+E++ L+ +FD ELEL++ G ++D+
Sbjct: 1073 NKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDV 1132
Query: 1459 SDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSN 1518
+DWR +T+Y+ GY NH VI+WFW AV ++E+R+RLLQFVTGTS +P GFA L GSN
Sbjct: 1133 NDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSN 1192
Query: 1519 GPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTF 1569
GP+ F VE+WG LPRAHTCFNRLDLPPY SF L++KL A+E T F
Sbjct: 1193 GPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGF 1243
Score = 46.6 bits (109), Expect = 2e-04
Identities = 23/70 (32%), Positives = 35/70 (50%), Gaps = 1/70 (1%)
Query: 770 ATAQEEGATGGSQANGHQPLRSLPSVRQDVSRYQRVDEA-LPPNWEARIDSHGRIFYVDH 828
AT + T + G Q S Q V++ +++ LP WE R +GR F++DH
Sbjct: 730 ATVETSQLTSSQSSAGPQSQASTSDSGQQVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDH 789
Query: 829 VNRTTTWQRP 838
+TTTW+ P
Sbjct: 790 NTKTTTWEDP 799
>gi|21361472 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 3 [Homo sapiens]
Length = 955
Score = 430 bits (1106), Expect = e-120
Identities = 285/788 (36%), Positives = 419/788 (53%), Gaps = 58/788 (7%)
Query: 809 LPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQ--LNRRYQSI 866
LPP WE ++D+ GR +YV+H NRTT W RP+ + N+I+Q+ Q +RR++S
Sbjct: 195 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSS--ESDNNIRQINQEAAHRRFRSR 252
Query: 867 RRTMTNERPEENTNAIDGAGEEADFHQASADFRRENILPHSTSRSRITLLLQSPPVK--F 924
R + PE + +G + S + NI S + L L PP
Sbjct: 253 RHISEDLEPEPS----EGGDVPEPWETISEEV---NIAGDS-----LGLALPPPPASPGS 300
Query: 925 LISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHHFERYQHNRDLV---GFLN--- 978
SP+ L S T ++ + + ++R+ R D V G L
Sbjct: 301 RTSPQ---ELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS 357
Query: 979 -MFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPL-QSSRPTSALVHRQHLT 1036
+ + LP GWE + D +G+ ++V+HN+RTTT+ P + L + SA HL
Sbjct: 358 VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLI 417
Query: 1037 -----RQRSHSAGEVGEDSRHAGPPVLPRPSSTFNTVSRPQYQDMVPVAYND-----KIV 1086
R RS S+ V + G P + +T+S PQ P YN K+
Sbjct: 418 EPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ--PSPYNSPKPQHKVT 475
Query: 1087 -AFLRQPNIFEILQERQPDLTRNHSLREKIQFIRTEGTPGLVRLSS--DADLVMLLSLFE 1143
+FL I +P +++ + R + + +S DL L +E
Sbjct: 476 QSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWE 535
Query: 1144 EEIMSYVPPHALLHPSYCQSPRGSPVSSPQNSPGTQRANARAPA-PYKRDFEAKLRNFYR 1202
E I + H S + P Q PA PY R+F+ K F +
Sbjct: 536 ERIHLDGRTFYIDHNSKI---------TQWEDPRLQNPAITGPAVPYSREFKQKYDYFRK 586
Query: 1203 KLETKGYGQGPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPS 1262
KL K P + ++ + R+++ E+++ +IM R D+ + +L++ F E+GLDY G +
Sbjct: 587 KL--KKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVA 644
Query: 1263 REFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHH-EWFRFSGRILGLALIHQ 1321
RE+FFL+S+E+FNPYYGLFEYSA D YT+QI+P S + H +F F GR+ GLA+ H
Sbjct: 645 REWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHG 704
Query: 1322 YLLDAFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDNDIHDILDLTFTVNEEVFG 1381
LLD FF RPFYK +L L+D+E +D E++ SL+W+ +ND + LDL F ++EE FG
Sbjct: 705 KLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFG 763
Query: 1382 QITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVF 1441
Q + +LKP G+ I VT +NK+EYI+ +++WR V +Q + + GF E++ L+ +F
Sbjct: 764 QTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIF 823
Query: 1442 DARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVT 1501
D ELEL++ G ++D++DWR ++ Y+ GY NH VI+WFW AV + E+R+RLLQFVT
Sbjct: 824 DENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVT 883
Query: 1502 GTSSIPYEGFASLRGSNGPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLT 1561
GTS +P GFA L GSNGP+ F +E+WG LPRAHTCFNRLDLPPY +F L EKLL
Sbjct: 884 GTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLM 943
Query: 1562 AVEETSTF 1569
AVE F
Sbjct: 944 AVENAQGF 951
Score = 71.6 bits (174), Expect = 6e-12
Identities = 88/343 (25%), Positives = 121/343 (35%), Gaps = 105/343 (30%)
Query: 687 EPTSSG----PAEGSQESVCTAGSLPVVQVPSGEDEGPGAESATVPDQEELGEVWQRRGS 742
EP+ G P E E V AG + +P P A + +EL E RR
Sbjct: 262 EPSEGGDVPEPWETISEEVNIAGDSLGLALPP-----PPASPGSRTSPQELSEELSRRLQ 316
Query: 743 L--EGAAAAAESPPQEEGSAGEAQGTCEGATAQEEGATGGSQANGHQPLRSLPSVRQDVS 800
+ + S Q E S+ + A A++ GH P PSV
Sbjct: 317 ITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQ----------GHLPP---PSVA---- 359
Query: 801 RYQRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLN 860
Y LP WE R D+ GR +YV+H NRTTTW RP I Q+ +
Sbjct: 360 -YVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP--------------IMQLAE-- 402
Query: 861 RRYQSIRRTMTNERPEENTNAIDGAGEEADFHQASADFRRENILPHSTSRSRITLL---- 916
+ G+ ++ H RR P S S +TL
Sbjct: 403 -------------------DGASGSATNSNNHLIEPQIRR----PRSLSSPTVTLSAPLE 439
Query: 917 -LQSPPVKFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHHFERYQHNRDLVG 975
+ PV+ + PS Y N+ +H +T
Sbjct: 440 GAKDSPVRRAVKDTLSNPQSPQPSPY----NSPKPQHKVT-------------------- 475
Query: 976 FLNMFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRL 1018
Q LP GWEM+ G+ FF+DHN++TTT+ DPRL
Sbjct: 476 --------QSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRL 510
Score = 32.7 bits (73), Expect = 2.8
Identities = 30/126 (23%), Positives = 53/126 (42%), Gaps = 12/126 (9%)
Query: 198 KKGMFFNPDPYLKMSIQPGKKSSFPTCAHHGQERRSTIISNTTNPIWHREKYSFFALLTD 257
KK +F DPY+K+S+ ++ ++ I T NP W+ E Y
Sbjct: 34 KKDIFGASDPYVKLSLYVADENRELALV------QTKTIKKTLNPKWNEEFYFRVNPSNH 87
Query: 258 VLEIEIKDKFAKSRPIIKRFLGKLTIPVQRLLERQAIGDQMLSYNLGRRLPADH---VSG 314
L E+ F ++R FLG++ +P+ L ++ ++ P H V G
Sbjct: 88 RLLFEV---FDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKG 144
Query: 315 YLQFKV 320
+L+ K+
Sbjct: 145 FLRLKM 150
>gi|222352094 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 430 bits (1106), Expect = e-120
Identities = 285/788 (36%), Positives = 419/788 (53%), Gaps = 58/788 (7%)
Query: 809 LPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQ--LNRRYQSI 866
LPP WE ++D+ GR +YV+H NRTT W RP+ + N+I+Q+ Q +RR++S
Sbjct: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSS--ESDNNIRQINQEAAHRRFRSR 131
Query: 867 RRTMTNERPEENTNAIDGAGEEADFHQASADFRRENILPHSTSRSRITLLLQSPPVK--F 924
R + PE + +G + S + NI S + L L PP
Sbjct: 132 RHISEDLEPEPS----EGGDVPEPWETISEEV---NIAGDS-----LGLALPPPPASPGS 179
Query: 925 LISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHHFERYQHNRDLV---GFLN--- 978
SP+ L S T ++ + + ++R+ R D V G L
Sbjct: 180 RTSPQ---ELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS 236
Query: 979 -MFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPL-QSSRPTSALVHRQHLT 1036
+ + LP GWE + D +G+ ++V+HN+RTTT+ P + L + SA HL
Sbjct: 237 VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLI 296
Query: 1037 -----RQRSHSAGEVGEDSRHAGPPVLPRPSSTFNTVSRPQYQDMVPVAYND-----KIV 1086
R RS S+ V + G P + +T+S PQ P YN K+
Sbjct: 297 EPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ--PSPYNSPKPQHKVT 354
Query: 1087 -AFLRQPNIFEILQERQPDLTRNHSLREKIQFIRTEGTPGLVRLSS--DADLVMLLSLFE 1143
+FL I +P +++ + R + + +S DL L +E
Sbjct: 355 QSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWE 414
Query: 1144 EEIMSYVPPHALLHPSYCQSPRGSPVSSPQNSPGTQRANARAPA-PYKRDFEAKLRNFYR 1202
E I + H S + P Q PA PY R+F+ K F +
Sbjct: 415 ERIHLDGRTFYIDHNSKI---------TQWEDPRLQNPAITGPAVPYSREFKQKYDYFRK 465
Query: 1203 KLETKGYGQGPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPS 1262
KL K P + ++ + R+++ E+++ +IM R D+ + +L++ F E+GLDY G +
Sbjct: 466 KL--KKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVA 523
Query: 1263 REFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHH-EWFRFSGRILGLALIHQ 1321
RE+FFL+S+E+FNPYYGLFEYSA D YT+QI+P S + H +F F GR+ GLA+ H
Sbjct: 524 REWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHG 583
Query: 1322 YLLDAFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDNDIHDILDLTFTVNEEVFG 1381
LLD FF RPFYK +L L+D+E +D E++ SL+W+ +ND + LDL F ++EE FG
Sbjct: 584 KLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFG 642
Query: 1382 QITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVF 1441
Q + +LKP G+ I VT +NK+EYI+ +++WR V +Q + + GF E++ L+ +F
Sbjct: 643 QTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIF 702
Query: 1442 DARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVT 1501
D ELEL++ G ++D++DWR ++ Y+ GY NH VI+WFW AV + E+R+RLLQFVT
Sbjct: 703 DENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVT 762
Query: 1502 GTSSIPYEGFASLRGSNGPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLT 1561
GTS +P GFA L GSNGP+ F +E+WG LPRAHTCFNRLDLPPY +F L EKLL
Sbjct: 763 GTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLM 822
Query: 1562 AVEETSTF 1569
AVE F
Sbjct: 823 AVENAQGF 830
Score = 71.6 bits (174), Expect = 6e-12
Identities = 88/343 (25%), Positives = 121/343 (35%), Gaps = 105/343 (30%)
Query: 687 EPTSSG----PAEGSQESVCTAGSLPVVQVPSGEDEGPGAESATVPDQEELGEVWQRRGS 742
EP+ G P E E V AG + +P P A + +EL E RR
Sbjct: 141 EPSEGGDVPEPWETISEEVNIAGDSLGLALPP-----PPASPGSRTSPQELSEELSRRLQ 195
Query: 743 L--EGAAAAAESPPQEEGSAGEAQGTCEGATAQEEGATGGSQANGHQPLRSLPSVRQDVS 800
+ + S Q E S+ + A A++ GH P PSV
Sbjct: 196 ITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQ----------GHLPP---PSVA---- 238
Query: 801 RYQRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLN 860
Y LP WE R D+ GR +YV+H NRTTTW RP I Q+ +
Sbjct: 239 -YVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP--------------IMQLAE-- 281
Query: 861 RRYQSIRRTMTNERPEENTNAIDGAGEEADFHQASADFRRENILPHSTSRSRITLL---- 916
+ G+ ++ H RR P S S +TL
Sbjct: 282 -------------------DGASGSATNSNNHLIEPQIRR----PRSLSSPTVTLSAPLE 318
Query: 917 -LQSPPVKFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHHFERYQHNRDLVG 975
+ PV+ + PS Y N+ +H +T
Sbjct: 319 GAKDSPVRRAVKDTLSNPQSPQPSPY----NSPKPQHKVT-------------------- 354
Query: 976 FLNMFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRL 1018
Q LP GWEM+ G+ FF+DHN++TTT+ DPRL
Sbjct: 355 --------QSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRL 389
>gi|222352092 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 430 bits (1106), Expect = e-120
Identities = 285/788 (36%), Positives = 419/788 (53%), Gaps = 58/788 (7%)
Query: 809 LPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQ--LNRRYQSI 866
LPP WE ++D+ GR +YV+H NRTT W RP+ + N+I+Q+ Q +RR++S
Sbjct: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSS--ESDNNIRQINQEAAHRRFRSR 131
Query: 867 RRTMTNERPEENTNAIDGAGEEADFHQASADFRRENILPHSTSRSRITLLLQSPPVK--F 924
R + PE + +G + S + NI S + L L PP
Sbjct: 132 RHISEDLEPEPS----EGGDVPEPWETISEEV---NIAGDS-----LGLALPPPPASPGS 179
Query: 925 LISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHHFERYQHNRDLV---GFLN--- 978
SP+ L S T ++ + + ++R+ R D V G L
Sbjct: 180 RTSPQ---ELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS 236
Query: 979 -MFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPL-QSSRPTSALVHRQHLT 1036
+ + LP GWE + D +G+ ++V+HN+RTTT+ P + L + SA HL
Sbjct: 237 VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLI 296
Query: 1037 -----RQRSHSAGEVGEDSRHAGPPVLPRPSSTFNTVSRPQYQDMVPVAYND-----KIV 1086
R RS S+ V + G P + +T+S PQ P YN K+
Sbjct: 297 EPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ--PSPYNSPKPQHKVT 354
Query: 1087 -AFLRQPNIFEILQERQPDLTRNHSLREKIQFIRTEGTPGLVRLSS--DADLVMLLSLFE 1143
+FL I +P +++ + R + + +S DL L +E
Sbjct: 355 QSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWE 414
Query: 1144 EEIMSYVPPHALLHPSYCQSPRGSPVSSPQNSPGTQRANARAPA-PYKRDFEAKLRNFYR 1202
E I + H S + P Q PA PY R+F+ K F +
Sbjct: 415 ERIHLDGRTFYIDHNSKI---------TQWEDPRLQNPAITGPAVPYSREFKQKYDYFRK 465
Query: 1203 KLETKGYGQGPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPS 1262
KL K P + ++ + R+++ E+++ +IM R D+ + +L++ F E+GLDY G +
Sbjct: 466 KL--KKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVA 523
Query: 1263 REFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHH-EWFRFSGRILGLALIHQ 1321
RE+FFL+S+E+FNPYYGLFEYSA D YT+QI+P S + H +F F GR+ GLA+ H
Sbjct: 524 REWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHG 583
Query: 1322 YLLDAFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDNDIHDILDLTFTVNEEVFG 1381
LLD FF RPFYK +L L+D+E +D E++ SL+W+ +ND + LDL F ++EE FG
Sbjct: 584 KLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFG 642
Query: 1382 QITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVF 1441
Q + +LKP G+ I VT +NK+EYI+ +++WR V +Q + + GF E++ L+ +F
Sbjct: 643 QTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIF 702
Query: 1442 DARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVT 1501
D ELEL++ G ++D++DWR ++ Y+ GY NH VI+WFW AV + E+R+RLLQFVT
Sbjct: 703 DENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVT 762
Query: 1502 GTSSIPYEGFASLRGSNGPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLT 1561
GTS +P GFA L GSNGP+ F +E+WG LPRAHTCFNRLDLPPY +F L EKLL
Sbjct: 763 GTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLM 822
Query: 1562 AVEETSTF 1569
AVE F
Sbjct: 823 AVENAQGF 830
Score = 71.6 bits (174), Expect = 6e-12
Identities = 88/343 (25%), Positives = 121/343 (35%), Gaps = 105/343 (30%)
Query: 687 EPTSSG----PAEGSQESVCTAGSLPVVQVPSGEDEGPGAESATVPDQEELGEVWQRRGS 742
EP+ G P E E V AG + +P P A + +EL E RR
Sbjct: 141 EPSEGGDVPEPWETISEEVNIAGDSLGLALPP-----PPASPGSRTSPQELSEELSRRLQ 195
Query: 743 L--EGAAAAAESPPQEEGSAGEAQGTCEGATAQEEGATGGSQANGHQPLRSLPSVRQDVS 800
+ + S Q E S+ + A A++ GH P PSV
Sbjct: 196 ITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQ----------GHLPP---PSVA---- 238
Query: 801 RYQRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLN 860
Y LP WE R D+ GR +YV+H NRTTTW RP I Q+ +
Sbjct: 239 -YVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP--------------IMQLAE-- 281
Query: 861 RRYQSIRRTMTNERPEENTNAIDGAGEEADFHQASADFRRENILPHSTSRSRITLL---- 916
+ G+ ++ H RR P S S +TL
Sbjct: 282 -------------------DGASGSATNSNNHLIEPQIRR----PRSLSSPTVTLSAPLE 318
Query: 917 -LQSPPVKFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHHFERYQHNRDLVG 975
+ PV+ + PS Y N+ +H +T
Sbjct: 319 GAKDSPVRRAVKDTLSNPQSPQPSPY----NSPKPQHKVT-------------------- 354
Query: 976 FLNMFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRL 1018
Q LP GWEM+ G+ FF+DHN++TTT+ DPRL
Sbjct: 355 --------QSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRL 389
>gi|222352090 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 5 [Homo sapiens]
Length = 947
Score = 430 bits (1106), Expect = e-120
Identities = 285/788 (36%), Positives = 419/788 (53%), Gaps = 58/788 (7%)
Query: 809 LPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQ--LNRRYQSI 866
LPP WE ++D+ GR +YV+H NRTT W RP+ + N+I+Q+ Q +RR++S
Sbjct: 187 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSS--ESDNNIRQINQEAAHRRFRSR 244
Query: 867 RRTMTNERPEENTNAIDGAGEEADFHQASADFRRENILPHSTSRSRITLLLQSPPVK--F 924
R + PE + +G + S + NI S + L L PP
Sbjct: 245 RHISEDLEPEPS----EGGDVPEPWETISEEV---NIAGDS-----LGLALPPPPASPGS 292
Query: 925 LISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHHFERYQHNRDLV---GFLN--- 978
SP+ L S T ++ + + ++R+ R D V G L
Sbjct: 293 RTSPQ---ELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS 349
Query: 979 -MFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPL-QSSRPTSALVHRQHLT 1036
+ + LP GWE + D +G+ ++V+HN+RTTT+ P + L + SA HL
Sbjct: 350 VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLI 409
Query: 1037 -----RQRSHSAGEVGEDSRHAGPPVLPRPSSTFNTVSRPQYQDMVPVAYND-----KIV 1086
R RS S+ V + G P + +T+S PQ P YN K+
Sbjct: 410 EPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ--PSPYNSPKPQHKVT 467
Query: 1087 -AFLRQPNIFEILQERQPDLTRNHSLREKIQFIRTEGTPGLVRLSS--DADLVMLLSLFE 1143
+FL I +P +++ + R + + +S DL L +E
Sbjct: 468 QSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWE 527
Query: 1144 EEIMSYVPPHALLHPSYCQSPRGSPVSSPQNSPGTQRANARAPA-PYKRDFEAKLRNFYR 1202
E I + H S + P Q PA PY R+F+ K F +
Sbjct: 528 ERIHLDGRTFYIDHNSKI---------TQWEDPRLQNPAITGPAVPYSREFKQKYDYFRK 578
Query: 1203 KLETKGYGQGPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPS 1262
KL K P + ++ + R+++ E+++ +IM R D+ + +L++ F E+GLDY G +
Sbjct: 579 KL--KKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVA 636
Query: 1263 REFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHH-EWFRFSGRILGLALIHQ 1321
RE+FFL+S+E+FNPYYGLFEYSA D YT+QI+P S + H +F F GR+ GLA+ H
Sbjct: 637 REWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHG 696
Query: 1322 YLLDAFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDNDIHDILDLTFTVNEEVFG 1381
LLD FF RPFYK +L L+D+E +D E++ SL+W+ +ND + LDL F ++EE FG
Sbjct: 697 KLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFG 755
Query: 1382 QITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVF 1441
Q + +LKP G+ I VT +NK+EYI+ +++WR V +Q + + GF E++ L+ +F
Sbjct: 756 QTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIF 815
Query: 1442 DARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVT 1501
D ELEL++ G ++D++DWR ++ Y+ GY NH VI+WFW AV + E+R+RLLQFVT
Sbjct: 816 DENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVT 875
Query: 1502 GTSSIPYEGFASLRGSNGPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLT 1561
GTS +P GFA L GSNGP+ F +E+WG LPRAHTCFNRLDLPPY +F L EKLL
Sbjct: 876 GTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLM 935
Query: 1562 AVEETSTF 1569
AVE F
Sbjct: 936 AVENAQGF 943
Score = 71.6 bits (174), Expect = 6e-12
Identities = 88/343 (25%), Positives = 121/343 (35%), Gaps = 105/343 (30%)
Query: 687 EPTSSG----PAEGSQESVCTAGSLPVVQVPSGEDEGPGAESATVPDQEELGEVWQRRGS 742
EP+ G P E E V AG + +P P A + +EL E RR
Sbjct: 254 EPSEGGDVPEPWETISEEVNIAGDSLGLALPP-----PPASPGSRTSPQELSEELSRRLQ 308
Query: 743 L--EGAAAAAESPPQEEGSAGEAQGTCEGATAQEEGATGGSQANGHQPLRSLPSVRQDVS 800
+ + S Q E S+ + A A++ GH P PSV
Sbjct: 309 ITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQ----------GHLPP---PSVA---- 351
Query: 801 RYQRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLN 860
Y LP WE R D+ GR +YV+H NRTTTW RP I Q+ +
Sbjct: 352 -YVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP--------------IMQLAE-- 394
Query: 861 RRYQSIRRTMTNERPEENTNAIDGAGEEADFHQASADFRRENILPHSTSRSRITLL---- 916
+ G+ ++ H RR P S S +TL
Sbjct: 395 -------------------DGASGSATNSNNHLIEPQIRR----PRSLSSPTVTLSAPLE 431
Query: 917 -LQSPPVKFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHHFERYQHNRDLVG 975
+ PV+ + PS Y N+ +H +T
Sbjct: 432 GAKDSPVRRAVKDTLSNPQSPQPSPY----NSPKPQHKVT-------------------- 467
Query: 976 FLNMFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRL 1018
Q LP GWEM+ G+ FF+DHN++TTT+ DPRL
Sbjct: 468 --------QSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRL 502
Score = 32.7 bits (73), Expect = 2.8
Identities = 30/126 (23%), Positives = 53/126 (42%), Gaps = 12/126 (9%)
Query: 198 KKGMFFNPDPYLKMSIQPGKKSSFPTCAHHGQERRSTIISNTTNPIWHREKYSFFALLTD 257
KK +F DPY+K+S+ ++ ++ I T NP W+ E Y
Sbjct: 26 KKDIFGASDPYVKLSLYVADENRELALV------QTKTIKKTLNPKWNEEFYFRVNPSNH 79
Query: 258 VLEIEIKDKFAKSRPIIKRFLGKLTIPVQRLLERQAIGDQMLSYNLGRRLPADH---VSG 314
L E+ F ++R FLG++ +P+ L ++ ++ P H V G
Sbjct: 80 RLLFEV---FDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKG 136
Query: 315 YLQFKV 320
+L+ K+
Sbjct: 137 FLRLKM 142
>gi|222352183 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 400 bits (1027), Expect = e-111
Identities = 237/599 (39%), Positives = 342/599 (57%), Gaps = 30/599 (5%)
Query: 987 LPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPL-QSSRPTSALVHRQHLT-----RQRS 1040
LP GWE + D +G+ ++V+HN+RTTT+ P + L + SA HL R RS
Sbjct: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 325
Query: 1041 HSAGEVGEDSRHAGPPVLPRPSSTFNTVSRPQYQDMVPVAYND-----KIV-AFLRQPNI 1094
S+ V + G P + +T+S PQ P YN K+ +FL
Sbjct: 326 LSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ--PSPYNSPKPQHKVTQSFLPPGWE 383
Query: 1095 FEILQERQPDLTRNHSLREKIQFIRTEGTPGLVRLSS--DADLVMLLSLFEEEIMSYVPP 1152
I +P +++ + R + + +S DL L +EE I
Sbjct: 384 MRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRT 443
Query: 1153 HALLHPSYCQSPRGSPVSSPQNSPGTQRANARAPA-PYKRDFEAKLRNFYRKLETKGYGQ 1211
+ H S + P Q PA PY R+F+ K F +KL K
Sbjct: 444 FYIDHNSKI---------TQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKL--KKPAD 492
Query: 1212 GPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSR 1271
P + ++ + R+++ E+++ +IM R D+ + +L++ F E+GLDY G +RE+FFL+S+
Sbjct: 493 IPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSK 552
Query: 1272 ELFNPYYGLFEYSANDTYTVQISPMSAFVDNHH-EWFRFSGRILGLALIHQYLLDAFFTR 1330
E+FNPYYGLFEYSA D YT+QI+P S + H +F F GR+ GLA+ H LLD FF R
Sbjct: 553 EMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIR 612
Query: 1331 PFYKALLRILCDLSDLEYLDEEFHQSLQWMKDNDIHDILDLTFTVNEEVFGQITERELKP 1390
PFYK +L L+D+E +D E++ SL+W+ +ND + LDL F ++EE FGQ + +LKP
Sbjct: 613 PFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKP 671
Query: 1391 GGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVI 1450
G+ I VT +NK+EYI+ +++WR V +Q + + GF E++ L+ +FD ELEL++
Sbjct: 672 NGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLM 731
Query: 1451 AGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEG 1510
G ++D++DWR ++ Y+ GY NH VI+WFW AV + E+R+RLLQFVTGTS +P G
Sbjct: 732 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 791
Query: 1511 FASLRGSNGPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTF 1569
FA L GSNGP+ F +E+WG LPRAHTCFNRLDLPPY +F L EKLL AVE F
Sbjct: 792 FAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850
Score = 72.4 bits (176), Expect = 3e-12
Identities = 89/355 (25%), Positives = 123/355 (34%), Gaps = 109/355 (30%)
Query: 687 EPTSSG----PAEGSQESVCTAGSLPVVQVPSGEDEGPGAESATVPDQEELGEVWQRRGS 742
EP+ G P E E V AG + +P P A + +EL E RR
Sbjct: 141 EPSEGGDVPEPWETISEEVNIAGDSLGLALPP-----PPASPGSRTSPQELSEELSRRLQ 195
Query: 743 L--EGAAAAAESPPQEEGSAGEAQGTCEGATAQEEGATGGSQANGHQPLRSLPSVRQDVS 800
+ + S Q E S+ + A A++ GH P S P+ R S
Sbjct: 196 ITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQ----------GHLPPPSAPAGRARSS 245
Query: 801 R------------YQRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQ 848
Y LP WE R D+ GR +YV+H NRTTTW RP
Sbjct: 246 TVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP---------- 295
Query: 849 RSNSIQQMEQLNRRYQSIRRTMTNERPEENTNAIDGAGEEADFHQASADFRRENILPHST 908
I Q+ + + G+ ++ H RR P S
Sbjct: 296 ----IMQLAE---------------------DGASGSATNSNNHLIEPQIRR----PRSL 326
Query: 909 SRSRITLL-----LQSPPVKFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHH 963
S +TL + PV+ + PS Y N+ +H +T
Sbjct: 327 SSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPY----NSPKPQHKVT-------- 374
Query: 964 FERYQHNRDLVGFLNMFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRL 1018
Q LP GWEM+ G+ FF+DHN++TTT+ DPRL
Sbjct: 375 --------------------QSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRL 409
Score = 57.0 bits (136), Expect = 1e-07
Identities = 28/70 (40%), Positives = 42/70 (60%), Gaps = 4/70 (5%)
Query: 809 LPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQ--LNRRYQSI 866
LPP WE ++D+ GR +YV+H NRTT W RP+ + N+I+Q+ Q +RR++S
Sbjct: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSS--ESDNNIRQINQEAAHRRFRSR 131
Query: 867 RRTMTNERPE 876
R + PE
Sbjct: 132 RHISEDLEPE 141
Score = 42.7 bits (99), Expect = 0.003
Identities = 16/30 (53%), Positives = 20/30 (66%)
Query: 809 LPPNWEARIDSHGRIFYVDHVNRTTTWQRP 838
LPP WE RI GR FY+DH ++ T W+ P
Sbjct: 429 LPPGWEERIHLDGRTFYIDHNSKITQWEDP 458
Score = 42.0 bits (97), Expect = 0.005
Identities = 23/64 (35%), Positives = 34/64 (53%), Gaps = 1/64 (1%)
Query: 987 LPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPLQSSRPTSALVH-RQHLTRQRSHSAGE 1045
LP GWE K D+ G+ ++V+HN+RTT + P L SS + + Q +R S
Sbjct: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRH 133
Query: 1046 VGED 1049
+ ED
Sbjct: 134 ISED 137
>gi|222352088 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 4 [Homo sapiens]
Length = 967
Score = 400 bits (1027), Expect = e-111
Identities = 237/599 (39%), Positives = 342/599 (57%), Gaps = 30/599 (5%)
Query: 987 LPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPL-QSSRPTSALVHRQHLT-----RQRS 1040
LP GWE + D +G+ ++V+HN+RTTT+ P + L + SA HL R RS
Sbjct: 379 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 438
Query: 1041 HSAGEVGEDSRHAGPPVLPRPSSTFNTVSRPQYQDMVPVAYND-----KIV-AFLRQPNI 1094
S+ V + G P + +T+S PQ P YN K+ +FL
Sbjct: 439 LSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ--PSPYNSPKPQHKVTQSFLPPGWE 496
Query: 1095 FEILQERQPDLTRNHSLREKIQFIRTEGTPGLVRLSS--DADLVMLLSLFEEEIMSYVPP 1152
I +P +++ + R + + +S DL L +EE I
Sbjct: 497 MRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRT 556
Query: 1153 HALLHPSYCQSPRGSPVSSPQNSPGTQRANARAPA-PYKRDFEAKLRNFYRKLETKGYGQ 1211
+ H S + P Q PA PY R+F+ K F +KL K
Sbjct: 557 FYIDHNSKI---------TQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKL--KKPAD 605
Query: 1212 GPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSR 1271
P + ++ + R+++ E+++ +IM R D+ + +L++ F E+GLDY G +RE+FFL+S+
Sbjct: 606 IPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSK 665
Query: 1272 ELFNPYYGLFEYSANDTYTVQISPMSAFVDNHH-EWFRFSGRILGLALIHQYLLDAFFTR 1330
E+FNPYYGLFEYSA D YT+QI+P S + H +F F GR+ GLA+ H LLD FF R
Sbjct: 666 EMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIR 725
Query: 1331 PFYKALLRILCDLSDLEYLDEEFHQSLQWMKDNDIHDILDLTFTVNEEVFGQITERELKP 1390
PFYK +L L+D+E +D E++ SL+W+ +ND + LDL F ++EE FGQ + +LKP
Sbjct: 726 PFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKP 784
Query: 1391 GGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVI 1450
G+ I VT +NK+EYI+ +++WR V +Q + + GF E++ L+ +FD ELEL++
Sbjct: 785 NGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLM 844
Query: 1451 AGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEG 1510
G ++D++DWR ++ Y+ GY NH VI+WFW AV + E+R+RLLQFVTGTS +P G
Sbjct: 845 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 904
Query: 1511 FASLRGSNGPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTF 1569
FA L GSNGP+ F +E+WG LPRAHTCFNRLDLPPY +F L EKLL AVE F
Sbjct: 905 FAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 963
Score = 72.4 bits (176), Expect = 3e-12
Identities = 89/355 (25%), Positives = 123/355 (34%), Gaps = 109/355 (30%)
Query: 687 EPTSSG----PAEGSQESVCTAGSLPVVQVPSGEDEGPGAESATVPDQEELGEVWQRRGS 742
EP+ G P E E V AG + +P P A + +EL E RR
Sbjct: 254 EPSEGGDVPEPWETISEEVNIAGDSLGLALPP-----PPASPGSRTSPQELSEELSRRLQ 308
Query: 743 L--EGAAAAAESPPQEEGSAGEAQGTCEGATAQEEGATGGSQANGHQPLRSLPSVRQDVS 800
+ + S Q E S+ + A A++ GH P S P+ R S
Sbjct: 309 ITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQ----------GHLPPPSAPAGRARSS 358
Query: 801 R------------YQRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQ 848
Y LP WE R D+ GR +YV+H NRTTTW RP
Sbjct: 359 TVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP---------- 408
Query: 849 RSNSIQQMEQLNRRYQSIRRTMTNERPEENTNAIDGAGEEADFHQASADFRRENILPHST 908
I Q+ + + G+ ++ H RR P S
Sbjct: 409 ----IMQLAE---------------------DGASGSATNSNNHLIEPQIRR----PRSL 439
Query: 909 SRSRITLL-----LQSPPVKFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHH 963
S +TL + PV+ + PS Y N+ +H +T
Sbjct: 440 SSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPY----NSPKPQHKVT-------- 487
Query: 964 FERYQHNRDLVGFLNMFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRL 1018
Q LP GWEM+ G+ FF+DHN++TTT+ DPRL
Sbjct: 488 --------------------QSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRL 522
Score = 57.0 bits (136), Expect = 1e-07
Identities = 28/70 (40%), Positives = 42/70 (60%), Gaps = 4/70 (5%)
Query: 809 LPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQ--LNRRYQSI 866
LPP WE ++D+ GR +YV+H NRTT W RP+ + N+I+Q+ Q +RR++S
Sbjct: 187 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSS--ESDNNIRQINQEAAHRRFRSR 244
Query: 867 RRTMTNERPE 876
R + PE
Sbjct: 245 RHISEDLEPE 254
Score = 42.7 bits (99), Expect = 0.003
Identities = 16/30 (53%), Positives = 20/30 (66%)
Query: 809 LPPNWEARIDSHGRIFYVDHVNRTTTWQRP 838
LPP WE RI GR FY+DH ++ T W+ P
Sbjct: 542 LPPGWEERIHLDGRTFYIDHNSKITQWEDP 571
Score = 42.0 bits (97), Expect = 0.005
Identities = 23/64 (35%), Positives = 34/64 (53%), Gaps = 1/64 (1%)
Query: 987 LPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPLQSSRPTSALVH-RQHLTRQRSHSAGE 1045
LP GWE K D+ G+ ++V+HN+RTT + P L SS + + Q +R S
Sbjct: 187 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRH 246
Query: 1046 VGED 1049
+ ED
Sbjct: 247 ISED 250
Score = 32.7 bits (73), Expect = 2.8
Identities = 30/126 (23%), Positives = 53/126 (42%), Gaps = 12/126 (9%)
Query: 198 KKGMFFNPDPYLKMSIQPGKKSSFPTCAHHGQERRSTIISNTTNPIWHREKYSFFALLTD 257
KK +F DPY+K+S+ ++ ++ I T NP W+ E Y
Sbjct: 26 KKDIFGASDPYVKLSLYVADENRELALV------QTKTIKKTLNPKWNEEFYFRVNPSNH 79
Query: 258 VLEIEIKDKFAKSRPIIKRFLGKLTIPVQRLLERQAIGDQMLSYNLGRRLPADH---VSG 314
L E+ F ++R FLG++ +P+ L ++ ++ P H V G
Sbjct: 80 RLLFEV---FDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKG 136
Query: 315 YLQFKV 320
+L+ K+
Sbjct: 137 FLRLKM 142
>gi|222352086 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 1 [Homo sapiens]
Length = 975
Score = 400 bits (1027), Expect = e-111
Identities = 237/599 (39%), Positives = 342/599 (57%), Gaps = 30/599 (5%)
Query: 987 LPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPL-QSSRPTSALVHRQHLT-----RQRS 1040
LP GWE + D +G+ ++V+HN+RTTT+ P + L + SA HL R RS
Sbjct: 387 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 446
Query: 1041 HSAGEVGEDSRHAGPPVLPRPSSTFNTVSRPQYQDMVPVAYND-----KIV-AFLRQPNI 1094
S+ V + G P + +T+S PQ P YN K+ +FL
Sbjct: 447 LSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ--PSPYNSPKPQHKVTQSFLPPGWE 504
Query: 1095 FEILQERQPDLTRNHSLREKIQFIRTEGTPGLVRLSS--DADLVMLLSLFEEEIMSYVPP 1152
I +P +++ + R + + +S DL L +EE I
Sbjct: 505 MRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRT 564
Query: 1153 HALLHPSYCQSPRGSPVSSPQNSPGTQRANARAPA-PYKRDFEAKLRNFYRKLETKGYGQ 1211
+ H S + P Q PA PY R+F+ K F +KL K
Sbjct: 565 FYIDHNSKI---------TQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKL--KKPAD 613
Query: 1212 GPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSR 1271
P + ++ + R+++ E+++ +IM R D+ + +L++ F E+GLDY G +RE+FFL+S+
Sbjct: 614 IPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSK 673
Query: 1272 ELFNPYYGLFEYSANDTYTVQISPMSAFVDNHH-EWFRFSGRILGLALIHQYLLDAFFTR 1330
E+FNPYYGLFEYSA D YT+QI+P S + H +F F GR+ GLA+ H LLD FF R
Sbjct: 674 EMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIR 733
Query: 1331 PFYKALLRILCDLSDLEYLDEEFHQSLQWMKDNDIHDILDLTFTVNEEVFGQITERELKP 1390
PFYK +L L+D+E +D E++ SL+W+ +ND + LDL F ++EE FGQ + +LKP
Sbjct: 734 PFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKP 792
Query: 1391 GGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVI 1450
G+ I VT +NK+EYI+ +++WR V +Q + + GF E++ L+ +FD ELEL++
Sbjct: 793 NGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLM 852
Query: 1451 AGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEG 1510
G ++D++DWR ++ Y+ GY NH VI+WFW AV + E+R+RLLQFVTGTS +P G
Sbjct: 853 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 912
Query: 1511 FASLRGSNGPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTF 1569
FA L GSNGP+ F +E+WG LPRAHTCFNRLDLPPY +F L EKLL AVE F
Sbjct: 913 FAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 971
Score = 72.4 bits (176), Expect = 3e-12
Identities = 89/355 (25%), Positives = 123/355 (34%), Gaps = 109/355 (30%)
Query: 687 EPTSSG----PAEGSQESVCTAGSLPVVQVPSGEDEGPGAESATVPDQEELGEVWQRRGS 742
EP+ G P E E V AG + +P P A + +EL E RR
Sbjct: 262 EPSEGGDVPEPWETISEEVNIAGDSLGLALPP-----PPASPGSRTSPQELSEELSRRLQ 316
Query: 743 L--EGAAAAAESPPQEEGSAGEAQGTCEGATAQEEGATGGSQANGHQPLRSLPSVRQDVS 800
+ + S Q E S+ + A A++ GH P S P+ R S
Sbjct: 317 ITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQ----------GHLPPPSAPAGRARSS 366
Query: 801 R------------YQRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQ 848
Y LP WE R D+ GR +YV+H NRTTTW RP
Sbjct: 367 TVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP---------- 416
Query: 849 RSNSIQQMEQLNRRYQSIRRTMTNERPEENTNAIDGAGEEADFHQASADFRRENILPHST 908
I Q+ + + G+ ++ H RR P S
Sbjct: 417 ----IMQLAE---------------------DGASGSATNSNNHLIEPQIRR----PRSL 447
Query: 909 SRSRITLL-----LQSPPVKFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHH 963
S +TL + PV+ + PS Y N+ +H +T
Sbjct: 448 SSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPY----NSPKPQHKVT-------- 495
Query: 964 FERYQHNRDLVGFLNMFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRL 1018
Q LP GWEM+ G+ FF+DHN++TTT+ DPRL
Sbjct: 496 --------------------QSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRL 530
Score = 57.0 bits (136), Expect = 1e-07
Identities = 28/70 (40%), Positives = 42/70 (60%), Gaps = 4/70 (5%)
Query: 809 LPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQ--LNRRYQSI 866
LPP WE ++D+ GR +YV+H NRTT W RP+ + N+I+Q+ Q +RR++S
Sbjct: 195 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSS--ESDNNIRQINQEAAHRRFRSR 252
Query: 867 RRTMTNERPE 876
R + PE
Sbjct: 253 RHISEDLEPE 262
Score = 42.7 bits (99), Expect = 0.003
Identities = 16/30 (53%), Positives = 20/30 (66%)
Query: 809 LPPNWEARIDSHGRIFYVDHVNRTTTWQRP 838
LPP WE RI GR FY+DH ++ T W+ P
Sbjct: 550 LPPGWEERIHLDGRTFYIDHNSKITQWEDP 579
Score = 42.0 bits (97), Expect = 0.005
Identities = 23/64 (35%), Positives = 34/64 (53%), Gaps = 1/64 (1%)
Query: 987 LPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPLQSSRPTSALVH-RQHLTRQRSHSAGE 1045
LP GWE K D+ G+ ++V+HN+RTT + P L SS + + Q +R S
Sbjct: 195 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRH 254
Query: 1046 VGED 1049
+ ED
Sbjct: 255 ISED 258
Score = 32.7 bits (73), Expect = 2.8
Identities = 30/126 (23%), Positives = 53/126 (42%), Gaps = 12/126 (9%)
Query: 198 KKGMFFNPDPYLKMSIQPGKKSSFPTCAHHGQERRSTIISNTTNPIWHREKYSFFALLTD 257
KK +F DPY+K+S+ ++ ++ I T NP W+ E Y
Sbjct: 34 KKDIFGASDPYVKLSLYVADENRELALV------QTKTIKKTLNPKWNEEFYFRVNPSNH 87
Query: 258 VLEIEIKDKFAKSRPIIKRFLGKLTIPVQRLLERQAIGDQMLSYNLGRRLPADH---VSG 314
L E+ F ++R FLG++ +P+ L ++ ++ P H V G
Sbjct: 88 RLLFEV---FDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKG 144
Query: 315 YLQFKV 320
+L+ K+
Sbjct: 145 FLRLKM 150
>gi|222352084 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 400 bits (1027), Expect = e-111
Identities = 237/599 (39%), Positives = 342/599 (57%), Gaps = 30/599 (5%)
Query: 987 LPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPL-QSSRPTSALVHRQHLT-----RQRS 1040
LP GWE + D +G+ ++V+HN+RTTT+ P + L + SA HL R RS
Sbjct: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 325
Query: 1041 HSAGEVGEDSRHAGPPVLPRPSSTFNTVSRPQYQDMVPVAYND-----KIV-AFLRQPNI 1094
S+ V + G P + +T+S PQ P YN K+ +FL
Sbjct: 326 LSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ--PSPYNSPKPQHKVTQSFLPPGWE 383
Query: 1095 FEILQERQPDLTRNHSLREKIQFIRTEGTPGLVRLSS--DADLVMLLSLFEEEIMSYVPP 1152
I +P +++ + R + + +S DL L +EE I
Sbjct: 384 MRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRT 443
Query: 1153 HALLHPSYCQSPRGSPVSSPQNSPGTQRANARAPA-PYKRDFEAKLRNFYRKLETKGYGQ 1211
+ H S + P Q PA PY R+F+ K F +KL K
Sbjct: 444 FYIDHNSKI---------TQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKL--KKPAD 492
Query: 1212 GPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSR 1271
P + ++ + R+++ E+++ +IM R D+ + +L++ F E+GLDY G +RE+FFL+S+
Sbjct: 493 IPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSK 552
Query: 1272 ELFNPYYGLFEYSANDTYTVQISPMSAFVDNHH-EWFRFSGRILGLALIHQYLLDAFFTR 1330
E+FNPYYGLFEYSA D YT+QI+P S + H +F F GR+ GLA+ H LLD FF R
Sbjct: 553 EMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIR 612
Query: 1331 PFYKALLRILCDLSDLEYLDEEFHQSLQWMKDNDIHDILDLTFTVNEEVFGQITERELKP 1390
PFYK +L L+D+E +D E++ SL+W+ +ND + LDL F ++EE FGQ + +LKP
Sbjct: 613 PFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKP 671
Query: 1391 GGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVI 1450
G+ I VT +NK+EYI+ +++WR V +Q + + GF E++ L+ +FD ELEL++
Sbjct: 672 NGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLM 731
Query: 1451 AGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEG 1510
G ++D++DWR ++ Y+ GY NH VI+WFW AV + E+R+RLLQFVTGTS +P G
Sbjct: 732 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 791
Query: 1511 FASLRGSNGPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTF 1569
FA L GSNGP+ F +E+WG LPRAHTCFNRLDLPPY +F L EKLL AVE F
Sbjct: 792 FAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850
Score = 72.4 bits (176), Expect = 3e-12
Identities = 89/355 (25%), Positives = 123/355 (34%), Gaps = 109/355 (30%)
Query: 687 EPTSSG----PAEGSQESVCTAGSLPVVQVPSGEDEGPGAESATVPDQEELGEVWQRRGS 742
EP+ G P E E V AG + +P P A + +EL E RR
Sbjct: 141 EPSEGGDVPEPWETISEEVNIAGDSLGLALPP-----PPASPGSRTSPQELSEELSRRLQ 195
Query: 743 L--EGAAAAAESPPQEEGSAGEAQGTCEGATAQEEGATGGSQANGHQPLRSLPSVRQDVS 800
+ + S Q E S+ + A A++ GH P S P+ R S
Sbjct: 196 ITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQ----------GHLPPPSAPAGRARSS 245
Query: 801 R------------YQRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQ 848
Y LP WE R D+ GR +YV+H NRTTTW RP
Sbjct: 246 TVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP---------- 295
Query: 849 RSNSIQQMEQLNRRYQSIRRTMTNERPEENTNAIDGAGEEADFHQASADFRRENILPHST 908
I Q+ + + G+ ++ H RR P S
Sbjct: 296 ----IMQLAE---------------------DGASGSATNSNNHLIEPQIRR----PRSL 326
Query: 909 SRSRITLL-----LQSPPVKFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHH 963
S +TL + PV+ + PS Y N+ +H +T
Sbjct: 327 SSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPY----NSPKPQHKVT-------- 374
Query: 964 FERYQHNRDLVGFLNMFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRL 1018
Q LP GWEM+ G+ FF+DHN++TTT+ DPRL
Sbjct: 375 --------------------QSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRL 409
Score = 57.0 bits (136), Expect = 1e-07
Identities = 28/70 (40%), Positives = 42/70 (60%), Gaps = 4/70 (5%)
Query: 809 LPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQ--LNRRYQSI 866
LPP WE ++D+ GR +YV+H NRTT W RP+ + N+I+Q+ Q +RR++S
Sbjct: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSS--ESDNNIRQINQEAAHRRFRSR 131
Query: 867 RRTMTNERPE 876
R + PE
Sbjct: 132 RHISEDLEPE 141
Score = 42.7 bits (99), Expect = 0.003
Identities = 16/30 (53%), Positives = 20/30 (66%)
Query: 809 LPPNWEARIDSHGRIFYVDHVNRTTTWQRP 838
LPP WE RI GR FY+DH ++ T W+ P
Sbjct: 429 LPPGWEERIHLDGRTFYIDHNSKITQWEDP 458
Score = 42.0 bits (97), Expect = 0.005
Identities = 23/64 (35%), Positives = 34/64 (53%), Gaps = 1/64 (1%)
Query: 987 LPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPLQSSRPTSALVH-RQHLTRQRSHSAGE 1045
LP GWE K D+ G+ ++V+HN+RTT + P L SS + + Q +R S
Sbjct: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRH 133
Query: 1046 VGED 1049
+ ED
Sbjct: 134 ISED 137
>gi|222352082 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 400 bits (1027), Expect = e-111
Identities = 237/599 (39%), Positives = 342/599 (57%), Gaps = 30/599 (5%)
Query: 987 LPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPL-QSSRPTSALVHRQHLT-----RQRS 1040
LP GWE + D +G+ ++V+HN+RTTT+ P + L + SA HL R RS
Sbjct: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 325
Query: 1041 HSAGEVGEDSRHAGPPVLPRPSSTFNTVSRPQYQDMVPVAYND-----KIV-AFLRQPNI 1094
S+ V + G P + +T+S PQ P YN K+ +FL
Sbjct: 326 LSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ--PSPYNSPKPQHKVTQSFLPPGWE 383
Query: 1095 FEILQERQPDLTRNHSLREKIQFIRTEGTPGLVRLSS--DADLVMLLSLFEEEIMSYVPP 1152
I +P +++ + R + + +S DL L +EE I
Sbjct: 384 MRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRT 443
Query: 1153 HALLHPSYCQSPRGSPVSSPQNSPGTQRANARAPA-PYKRDFEAKLRNFYRKLETKGYGQ 1211
+ H S + P Q PA PY R+F+ K F +KL K
Sbjct: 444 FYIDHNSKI---------TQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKL--KKPAD 492
Query: 1212 GPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSR 1271
P + ++ + R+++ E+++ +IM R D+ + +L++ F E+GLDY G +RE+FFL+S+
Sbjct: 493 IPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSK 552
Query: 1272 ELFNPYYGLFEYSANDTYTVQISPMSAFVDNHH-EWFRFSGRILGLALIHQYLLDAFFTR 1330
E+FNPYYGLFEYSA D YT+QI+P S + H +F F GR+ GLA+ H LLD FF R
Sbjct: 553 EMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIR 612
Query: 1331 PFYKALLRILCDLSDLEYLDEEFHQSLQWMKDNDIHDILDLTFTVNEEVFGQITERELKP 1390
PFYK +L L+D+E +D E++ SL+W+ +ND + LDL F ++EE FGQ + +LKP
Sbjct: 613 PFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKP 671
Query: 1391 GGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVI 1450
G+ I VT +NK+EYI+ +++WR V +Q + + GF E++ L+ +FD ELEL++
Sbjct: 672 NGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLM 731
Query: 1451 AGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEG 1510
G ++D++DWR ++ Y+ GY NH VI+WFW AV + E+R+RLLQFVTGTS +P G
Sbjct: 732 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 791
Query: 1511 FASLRGSNGPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTF 1569
FA L GSNGP+ F +E+WG LPRAHTCFNRLDLPPY +F L EKLL AVE F
Sbjct: 792 FAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850
Score = 72.4 bits (176), Expect = 3e-12
Identities = 89/355 (25%), Positives = 123/355 (34%), Gaps = 109/355 (30%)
Query: 687 EPTSSG----PAEGSQESVCTAGSLPVVQVPSGEDEGPGAESATVPDQEELGEVWQRRGS 742
EP+ G P E E V AG + +P P A + +EL E RR
Sbjct: 141 EPSEGGDVPEPWETISEEVNIAGDSLGLALPP-----PPASPGSRTSPQELSEELSRRLQ 195
Query: 743 L--EGAAAAAESPPQEEGSAGEAQGTCEGATAQEEGATGGSQANGHQPLRSLPSVRQDVS 800
+ + S Q E S+ + A A++ GH P S P+ R S
Sbjct: 196 ITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQ----------GHLPPPSAPAGRARSS 245
Query: 801 R------------YQRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQ 848
Y LP WE R D+ GR +YV+H NRTTTW RP
Sbjct: 246 TVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP---------- 295
Query: 849 RSNSIQQMEQLNRRYQSIRRTMTNERPEENTNAIDGAGEEADFHQASADFRRENILPHST 908
I Q+ + + G+ ++ H RR P S
Sbjct: 296 ----IMQLAE---------------------DGASGSATNSNNHLIEPQIRR----PRSL 326
Query: 909 SRSRITLL-----LQSPPVKFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHH 963
S +TL + PV+ + PS Y N+ +H +T
Sbjct: 327 SSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPY----NSPKPQHKVT-------- 374
Query: 964 FERYQHNRDLVGFLNMFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRL 1018
Q LP GWEM+ G+ FF+DHN++TTT+ DPRL
Sbjct: 375 --------------------QSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRL 409
Score = 57.0 bits (136), Expect = 1e-07
Identities = 28/70 (40%), Positives = 42/70 (60%), Gaps = 4/70 (5%)
Query: 809 LPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQ--LNRRYQSI 866
LPP WE ++D+ GR +YV+H NRTT W RP+ + N+I+Q+ Q +RR++S
Sbjct: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSS--ESDNNIRQINQEAAHRRFRSR 131
Query: 867 RRTMTNERPE 876
R + PE
Sbjct: 132 RHISEDLEPE 141
Score = 42.7 bits (99), Expect = 0.003
Identities = 16/30 (53%), Positives = 20/30 (66%)
Query: 809 LPPNWEARIDSHGRIFYVDHVNRTTTWQRP 838
LPP WE RI GR FY+DH ++ T W+ P
Sbjct: 429 LPPGWEERIHLDGRTFYIDHNSKITQWEDP 458
Score = 42.0 bits (97), Expect = 0.005
Identities = 23/64 (35%), Positives = 34/64 (53%), Gaps = 1/64 (1%)
Query: 987 LPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPLQSSRPTSALVH-RQHLTRQRSHSAGE 1045
LP GWE K D+ G+ ++V+HN+RTT + P L SS + + Q +R S
Sbjct: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRH 133
Query: 1046 VGED 1049
+ ED
Sbjct: 134 ISED 137
>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
isoform 1 [Homo sapiens]
Length = 870
Score = 379 bits (972), Expect = e-104
Identities = 230/589 (39%), Positives = 324/589 (55%), Gaps = 53/589 (8%)
Query: 987 LPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPLQSSRPTSALVHR-QHLTRQRSHSAGE 1045
LP GWE + D +G+ ++VDHN+RTTT+ RPT+ V + QR+ G
Sbjct: 332 LPPGWEKRTDPRGRFYYVDHNTRTTTW---------QRPTAEYVRNYEQWQSQRNQLQGA 382
Query: 1046 VGEDSRHAGPPVLPRPSSTFNTVSRPQYQDMVPVAYNDKIVAFLRQPNIFEILQERQPDL 1105
+ +H L + SS + + + P+ P +E Q+
Sbjct: 383 M----QHFSQRFLYQSSS-----ASTDHDPLGPL------------PPGWEKRQDNGRVY 421
Query: 1106 TRNHSLRE-KIQFIRTEGTPGLVRLSSDADLVMLLSLFEEEIMSYVPPHALLHPSYCQSP 1164
NH+ R + + RT+G L ++ + E + Y H ++
Sbjct: 422 YVNHNTRTTQWEDPRTQGMIQEPALPPGWEMK-----YTSEGVRYFVDHNTRTTTFKDPR 476
Query: 1165 RGSPVSSPQNSPGTQRANARAPAPYKRDFEAKLRNFYRKLETKGYGQGPGKLKLIIRRDH 1224
G + Q SPG Y R F K F + P +K+ + R
Sbjct: 477 PGFESGTKQGSPGA----------YDRSFRWKYHQFRFLCHSNAL---PSHVKISVSRQT 523
Query: 1225 LLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYS 1284
L ED+F QIM DL+R +LY+ GEEGLDY G +RE+FFL+S E+ NP Y LFEY+
Sbjct: 524 LFEDSFQQIMNMKPYDLRR-RLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYA 582
Query: 1285 ANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRILCDLS 1344
+ Y +QI+P S+ +H +FRF GR + +AL H +D FT PFYK +L L
Sbjct: 583 GKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLK 642
Query: 1345 DLEYLDEEFHQSLQWMKDNDIHDI-LDLTFTVNEEVFGQITERELKPGGANIPVTEKNKK 1403
DLE +D EF+ S+ W+K+N++ + L+L F + E+ G++T ELK GG +I VTE+NK+
Sbjct: 643 DLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKE 702
Query: 1404 EYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRN 1463
EYI + WR RGV +QT++ + GF EV + FD +ELEL++ G EID+SDW+
Sbjct: 703 EYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQK 762
Query: 1464 NTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPRRF 1523
+T YR Y N I+WFW V+ +NE+R+RLLQFVTGT +P GFA L GSNGP++F
Sbjct: 763 STIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKF 821
Query: 1524 CVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGLE 1572
C++K GK T LPR+HTCFNRLDLPPY S+ L EKLL A+EET FG E
Sbjct: 822 CIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEETEGFGQE 870
Score = 76.3 bits (186), Expect = 2e-13
Identities = 80/307 (26%), Positives = 124/307 (40%), Gaps = 67/307 (21%)
Query: 745 GAAAAAESPPQEEGSAGEAQGTCEG----ATAQEEGATGGSQANGHQPLRSLP------- 793
GA + P + G +G A GT AT EE + G + PL P
Sbjct: 213 GARSRHRQPVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPPAAPLSVTPNPNTTSL 272
Query: 794 --------------SVRQDVSRYQRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPT 839
S Q + + +ALP WE R +GR++YVDH +TTTW+RP
Sbjct: 273 PAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP- 331
Query: 840 APPAPQVLQRSNSIQQMEQLNRRYQSIRRTMTNERPEENTNAIDGAGEEADFHQASADFR 899
PP + +R++ + ++ RT T +RP +A++
Sbjct: 332 LPPGWE--KRTDPRGRFYYVDHN----TRTTTWQRP-------------------TAEYV 366
Query: 900 RENILPHSTSRSRITLLLQSPPVKFLISPEFFTVLHSN----PSAYRMFTNNTCLKHMIT 955
R N + R+++ +Q +FL + H P + +N + ++
Sbjct: 367 R-NYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWEKRQDNGRVYYVNH 425
Query: 956 KVRRDTHHFERYQHNRDLVGFLNMFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFID 1015
R R Q G + ++ LP GWEMK+ +G +FVDHN+RTTTF D
Sbjct: 426 NTRTTQWEDPRTQ------GMI-----QEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKD 474
Query: 1016 PRLPLQS 1022
PR +S
Sbjct: 475 PRPGFES 481
Score = 62.0 bits (149), Expect = 4e-09
Identities = 68/260 (26%), Positives = 94/260 (36%), Gaps = 30/260 (11%)
Query: 585 SDASGGSRRAVSETESLDQGSEPSQVSSETEPSDPARTESVSEASTRPEGESDLECADSS 644
S SGG + ++D G+ P+ + P+R S + + PE +
Sbjct: 130 SVVSGGELTIFLDGPTVDLGNVPNGSALTDGSQLPSRDSSGTAVA--PENRHQPPSTNCF 187
Query: 645 CNESVTTQLSSVDTRCSSLESARFPETPAFSSQEEEDGACAAEPTSSGPAEGSQESVCTA 704
S T + S R + + P + Q ++ SG A G+ T
Sbjct: 188 GGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSG------HSGLANGTVNDEPTT 241
Query: 705 GSLPVVQVPSGEDEGPGAESATVPDQEELGEVWQRRGSLEGAAAAAESPPQEEGSAGEAQ 764
+ P G P A + P+ SL A AE EE S Q
Sbjct: 242 ATDPEEPSVVGVTSPPAAPLSVTPNPNTT--------SLPAPATPAEG---EEPSTSGTQ 290
Query: 765 GTCEGATAQEEGATGGSQANGHQPLRSLPSVR----QDVSRYQRVDEALPPNWEARIDSH 820
A A + G Q R LP+ R ++ + LPP WE R D
Sbjct: 291 QLPAAAQAPDALPAGWEQ-------RELPNGRVYYVDHNTKTTTWERPLPPGWEKRTDPR 343
Query: 821 GRIFYVDHVNRTTTWQRPTA 840
GR +YVDH RTTTWQRPTA
Sbjct: 344 GRFYYVDHNTRTTTWQRPTA 363
Score = 43.9 bits (102), Expect = 0.001
Identities = 76/335 (22%), Positives = 111/335 (33%), Gaps = 72/335 (21%)
Query: 563 GSAELCGSQEVDQPTSGADTGTSDASGGSRRAVSETESLDQGSEPSQVSSETEPSDPART 622
GSA GSQ + +SG + R T S + S + + PA
Sbjct: 154 GSALTDGSQLPSRDSSGTAVAPEN-----RHQPPSTNCFGGRSRTHRHSGASARTTPATG 208
Query: 623 ESVSEASTRPE------GESDLECADSSCNESVTTQLSSVDTRCSSLESARFPETPAFSS 676
E A +R G S L A+ + N+ TT + D S+ P PA
Sbjct: 209 EQSPGARSRHRQPVKNSGHSGL--ANGTVNDEPTT---ATDPEEPSVVGVTSP--PAAPL 261
Query: 677 QEEEDGACAAEPTSSGPAEGSQESVCTAGSLPVV--------------QVPSGEDEGPGA 722
+ + P + PAEG + S LP ++P+G
Sbjct: 262 SVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDH 321
Query: 723 ESATVPDQEELGEVWQRRGSLEG-----------------AAAAAESPPQEEGSAGEAQG 765
+ T + L W++R G A + Q + + QG
Sbjct: 322 NTKTTTWERPLPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQG 381
Query: 766 TCEGATAQEEGATGGSQANGHQPLRSLP---SVRQDVSRYQRVDE--------------- 807
+ + Q S + H PL LP RQD R V+
Sbjct: 382 AMQHFS-QRFLYQSSSASTDHDPLGPLPPGWEKRQDNGRVYYVNHNTRTTQWEDPRTQGM 440
Query: 808 ----ALPPNWEARIDSHGRIFYVDHVNRTTTWQRP 838
ALPP WE + S G ++VDH RTTT++ P
Sbjct: 441 IQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDP 475
>gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [Homo
sapiens]
Length = 922
Score = 377 bits (968), Expect = e-104
Identities = 231/589 (39%), Positives = 324/589 (55%), Gaps = 52/589 (8%)
Query: 987 LPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPLQSSRPTSALVHR-QHLTRQRSHSAGE 1045
LP GWE + D + + ++VDHN+RTTT+ RPT V + QR+ G
Sbjct: 383 LPPGWERRVDDRRRVYYVDHNTRTTTW---------QRPTMESVRNFEQWQSQRNQLQGA 433
Query: 1046 VGEDSRHAGPPVLPRPSSTFNTVSRPQYQDMVPVAYNDKIVAFLRQPNIFEILQERQPDL 1105
+ + FN R Y + A ND P + +
Sbjct: 434 MQQ----------------FN--QRYLYSASMLAAENDPYGPL--PPGWEKRVDSTDRVY 473
Query: 1106 TRNHSLRE-KIQFIRTEGTPGLVRLSSDADLVMLLSLFEEEIMSYVPPHALLHPSYCQSP 1164
NH+ + + + RT+G L ++ + E + Y H ++ + P
Sbjct: 474 FVNHNTKTTQWEDPRTQGLQNEEPLPEGWEI-----RYTREGVRYFVDHNTRTTTF-KDP 527
Query: 1165 RGSPVSSPQNSPGTQRANARAPAPYKRDFEAKLRNFYRKLETKGYGQGPGKLKLIIRRDH 1224
R S + P Y+R F KL +F ++ P +K+ + R
Sbjct: 528 RNGKSSVTKGGP---------QIAYERGFRWKLAHFRYLCQSNAL---PSHVKINVSRQT 575
Query: 1225 LLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYS 1284
L ED+F QIM DL+R +LYV F GEEGLDY G +RE+FFL+S E+ NP Y LFEY+
Sbjct: 576 LFEDSFQQIMALKPYDLRR-RLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYA 634
Query: 1285 ANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRILCDLS 1344
+ Y +QI+P S +H +F F GR + +AL H +D F+ PFYK +L +
Sbjct: 635 GKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIK 694
Query: 1345 DLEYLDEEFHQSLQWMKDNDIHDI-LDLTFTVNEEVFGQITERELKPGGANIPVTEKNKK 1403
DLE +D EF+ SL W++DN+I + L++ F+V+ E+ G++T +LK GG+NI VTE+NK
Sbjct: 695 DLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKD 754
Query: 1404 EYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRN 1463
EYI M +WR RGV +QT++ + GF EVV + + FD +ELE+++ G E+DL+DW+
Sbjct: 755 EYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQR 814
Query: 1464 NTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPRRF 1523
NT YR Y N I WFW V+ +NE R+RLLQFVTGT +P GFA L GSNGP++F
Sbjct: 815 NTVYRH-YTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKF 873
Query: 1524 CVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGLE 1572
C+EK GK T LPR+HTCFNRLDLPPY S+ L EKLL A+EET FG E
Sbjct: 874 CIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE 922
Score = 63.9 bits (154), Expect = 1e-09
Identities = 61/222 (27%), Positives = 84/222 (37%), Gaps = 52/222 (23%)
Query: 685 AAEPTSSGPAE----GSQESVCTAGSLPVVQVPSGEDEG---PGAESATVPDQ--EELGE 735
A +P +S PA+ G S + V P +E P S TV D +E+
Sbjct: 229 APKPLASEPADDTVNGESSSFAPTDNASVTGTPVVSEENALSPNCTSTTVEDPPVQEILT 288
Query: 736 VWQRRGSLEGAAAAAESPPQEEGSAGEAQGTCEGATAQEEGATGGSQANGHQPLRSLPSV 795
+ + +A ES EA+ E T+ ++ A QP + V
Sbjct: 289 SSENNECIPSTSAELES---------EARSILEPDTSNSRSSSAFEAAKSRQPDGCMDPV 339
Query: 796 RQDVSRY----------QRVD--------------------EALPPNWEARIDSHGRIFY 825
RQ QR D + LPP WE R+D R++Y
Sbjct: 340 RQQSGNANTETLPSGWEQRKDPHGRTYYVDHNTRTTTWERPQPLPPGWERRVDDRRRVYY 399
Query: 826 VDHVNRTTTWQRPTAPPA---PQVLQRSNSIQ-QMEQLNRRY 863
VDH RTTTWQRPT Q + N +Q M+Q N+RY
Sbjct: 400 VDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRY 441
Score = 47.8 bits (112), Expect = 9e-05
Identities = 32/111 (28%), Positives = 50/111 (45%), Gaps = 18/111 (16%)
Query: 809 LPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLNRRYQSIR- 867
LPP WE R+DS R+++V+H +TT W+ P Q LQ + + ++ + +R
Sbjct: 458 LPPGWEKRVDSTDRVYFVNHNTKTTQWE----DPRTQGLQNEEPLPEGWEIRYTREGVRY 513
Query: 868 ------RTMTNERPEENTNAIDGAGE----EADFHQASADFR---RENILP 905
RT T + P +++ G E F A FR + N LP
Sbjct: 514 FVDHNTRTTTFKDPRNGKSSVTKGGPQIAYERGFRWKLAHFRYLCQSNALP 564
Score = 43.1 bits (100), Expect = 0.002
Identities = 16/31 (51%), Positives = 23/31 (74%)
Query: 987 LPRGWEMKHDHQGKAFFVDHNSRTTTFIDPR 1017
LP GWE + D G+ ++VDHN+RTTT+ P+
Sbjct: 351 LPSGWEQRKDPHGRTYYVDHNTRTTTWERPQ 381
Score = 42.0 bits (97), Expect = 0.005
Identities = 26/79 (32%), Positives = 40/79 (50%), Gaps = 16/79 (20%)
Query: 963 HFERYQHNRD-LVGFLNMFANKQL--------------ELPRGWEMKHDHQGKAFFVDHN 1007
+FE++Q R+ L G + F + L LP GWE + D + +FV+HN
Sbjct: 419 NFEQWQSQRNQLQGAMQQFNQRYLYSASMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHN 478
Query: 1008 SRTTTFIDPRLP-LQSSRP 1025
++TT + DPR LQ+ P
Sbjct: 479 TKTTQWEDPRTQGLQNEEP 497
Score = 35.8 bits (81), Expect = 0.34
Identities = 15/33 (45%), Positives = 20/33 (60%)
Query: 806 DEALPPNWEARIDSHGRIFYVDHVNRTTTWQRP 838
+E LP WE R G ++VDH RTTT++ P
Sbjct: 495 EEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDP 527
>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapiens]
Length = 862
Score = 374 bits (960), Expect = e-103
Identities = 188/385 (48%), Positives = 260/385 (67%), Gaps = 6/385 (1%)
Query: 1189 YKRDFEAKLRNFYRKLETKGYGQGPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYV 1248
Y RDF+AK++ F + P +K+ + R L ED+F QIM +S +DL+R +L+V
Sbjct: 483 YVRDFKAKVQYFRFWCQQLAM---PQHIKITVTRKTLFEDSFQQIMSFSPQDLRR-RLWV 538
Query: 1249 TFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFR 1308
F GEEGLDY G +RE+FFL+S E+ NP Y LFEY+ D Y +QI+P S +H ++FR
Sbjct: 539 IFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFR 598
Query: 1309 FSGRILGLALIHQYLLDAFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDNDIHDI 1368
F GR + +AL H +D F+ PFYK +L L DLE +D EF+ SL W+K+N+I +
Sbjct: 599 FIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEEC 658
Query: 1369 -LDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVR 1427
L++ F+V++E+ G+I +LKP G NI VTE+NK+EYI + +WR+ RGV +QT++
Sbjct: 659 DLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFE 718
Query: 1428 GFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVER 1487
GF E++ + + FDA+ELE+++ G EIDL+DW+ + YR Y I WFW V+
Sbjct: 719 GFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRH-YARTSKQIMWFWQFVKE 777
Query: 1488 FNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPRRFCVEKWGKITALPRAHTCFNRLDLP 1547
+NE+R+RLLQFVTGT +P GFA L GSNGP++FC+EK GK LPR+HTCFNRLDLP
Sbjct: 778 IDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLP 837
Query: 1548 PYPSFSMLYEKLLTAVEETSTFGLE 1572
PY S+ L EKLL A+EET FG E
Sbjct: 838 PYKSYEQLKEKLLFAIEETEGFGQE 862
Score = 88.2 bits (217), Expect = 6e-17
Identities = 84/295 (28%), Positives = 124/295 (42%), Gaps = 64/295 (21%)
Query: 738 QRRGSLEGAAAAAESPPQEEGSAGEAQGTCEGATAQEEGATGG-------SQANGHQPLR 790
+R S+ G+ +A + +GS+ + T EGAT G S +G +PL
Sbjct: 224 RRPASVNGSPSATS---ESDGSSTGSLPPTNTNTNTSEGATSGLIIPLTISGGSGPRPLN 280
Query: 791 SLPSVRQDVSRYQRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRS 850
+ LPP WE R+D HGR++YVDHV + TTW RP P P +R
Sbjct: 281 PVTQA------------PLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPE--PLPPGWER- 325
Query: 851 NSIQQMEQLNRRY--QSIRRTMTNERP--EENTNAIDGAGEEADFHQASADFRRENILPH 906
+++ + R Y RT T +RP E N + + A F + I +
Sbjct: 326 ----RVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGN 381
Query: 907 ----STSRSRITLLLQSPPVKFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTH 962
+TS+S+ F L P + T++ + + R T
Sbjct: 382 QDLFATSQSKE-----------------FDPLGPLPPGWEKRTDSNGRVYFVNHNTRIT- 423
Query: 963 HFERYQHNRDLVGFLNMFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPR 1017
+++ R G LN + LP GWEM+ G +FVDHN RTTT+IDPR
Sbjct: 424 ---QWEDPRSQ-GQLN-----EKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPR 469
Score = 48.1 bits (113), Expect = 7e-05
Identities = 84/351 (23%), Positives = 125/351 (35%), Gaps = 47/351 (13%)
Query: 559 SADQGSAELCGSQEVDQPTSGADTGTSDASGGSRRAVSETESLDQGSEPSQVSSETEPSD 618
SA Q E T+G+D DA G R VS S PS + +PS
Sbjct: 159 SASQNDDGSRSKDETRVSTNGSDD-PEDAGAGENRRVSGNNS------PSLSNGGFKPSR 211
Query: 619 PAR-TESVSEASTRPEGESDLECADSSCNESVTTQLSSVDTRCSSLESAR----FPETPA 673
P R + RP + A S + S T L +T ++ E A P T +
Sbjct: 212 PPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEGATSGLIIPLTIS 271
Query: 674 FSSQEEEDGACAAEPTSSGPAE-GSQESVCTAGSLPVVQVPSGEDEGPGAESATVPDQEE 732
S G P + P G ++ V G + V E T D+ E
Sbjct: 272 GGS-----GPRPLNPVTQAPLPPGWEQRVDQHGRVYYVD---------HVEKRTTWDRPE 317
Query: 733 -LGEVWQRRGSLEGAAAAAESPPQEEGSAGEAQGTCEGATAQEEGATGGSQANGHQPLRS 791
L W+RR G + + + + T E E+ SQ G +
Sbjct: 318 PLPPGWERRVDNMGRIYYVDHFTR---TTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFN 374
Query: 792 LPSV--RQDVSRYQRVDE-----ALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTA---- 840
+ QD+ + E LPP WE R DS+GR+++V+H R T W+ P +
Sbjct: 375 QRFIYGNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQL 434
Query: 841 --PPAPQVLQRSNSIQQMEQLNRRYQSIRRTMTNERPEENTNAIDGAGEEA 889
P P+ + ++ + RRT T P +A+D + A
Sbjct: 435 NEKPLPEGWEMRFTVDGIPYF---VDHNRRTTTYIDPRTGKSALDNGPQIA 482
Score = 39.7 bits (91), Expect = 0.023
Identities = 16/32 (50%), Positives = 23/32 (71%)
Query: 987 LPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRL 1018
LP GWE + D+ G+ ++VDH +RTTT+ P L
Sbjct: 319 LPPGWERRVDNMGRIYYVDHFTRTTTWQRPTL 350
>gi|40806211 WW domain containing E3 ubiquitin protein ligase 2
isoform 2 [Homo sapiens]
Length = 431
Score = 363 bits (931), Expect = e-100
Identities = 186/389 (47%), Positives = 251/389 (64%), Gaps = 6/389 (1%)
Query: 1185 APAPYKRDFEAKLRNFYRKLETKGYGQGPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRN 1244
+P Y R F K F + P +K+ + R L ED+F QIM DL+R
Sbjct: 48 SPGAYDRSFRWKYHQFRFLCHSNAL---PSHVKISVSRQTLFEDSFQQIMNMKPYDLRR- 103
Query: 1245 KLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHH 1304
+LY+ GEEGLDY G +RE+FFL+S E+ NP Y LFEY+ + Y +QI+P S+ +H
Sbjct: 104 RLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHL 163
Query: 1305 EWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDND 1364
+FRF GR + +AL H +D FT PFYK +L L DLE +D EF+ S+ W+K+N+
Sbjct: 164 TYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENN 223
Query: 1365 IHDI-LDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTE 1423
+ + L+L F + E+ G++T ELK GG +I VTE+NK+EYI + WR RGV +QT+
Sbjct: 224 LEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTK 283
Query: 1424 SLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWA 1483
+ + GF EV + FD +ELEL++ G EID+SDW+ +T YR Y N I+WFW
Sbjct: 284 AFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQ 342
Query: 1484 AVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPRRFCVEKWGKITALPRAHTCFNR 1543
V+ +NE+R+RLLQFVTGT +P GFA L GSNGP++FC++K GK T LPR+HTCFNR
Sbjct: 343 VVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNR 402
Query: 1544 LDLPPYPSFSMLYEKLLTAVEETSTFGLE 1572
LDLPPY S+ L EKLL A+EET FG E
Sbjct: 403 LDLPPYKSYEQLREKLLYAIEETEGFGQE 431
Score = 51.6 bits (122), Expect = 6e-06
Identities = 22/36 (61%), Positives = 27/36 (75%)
Query: 987 LPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPLQS 1022
LP GWEMK+ +G +FVDHN+RTTTF DPR +S
Sbjct: 7 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFES 42
Score = 39.3 bits (90), Expect = 0.030
Identities = 16/33 (48%), Positives = 22/33 (66%)
Query: 806 DEALPPNWEARIDSHGRIFYVDHVNRTTTWQRP 838
+ ALPP WE + S G ++VDH RTTT++ P
Sbjct: 4 EPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDP 36
>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
sapiens]
Length = 748
Score = 363 bits (931), Expect = e-100
Identities = 181/385 (47%), Positives = 255/385 (66%), Gaps = 5/385 (1%)
Query: 1189 YKRDFEAKLRNFYRKLETKGYGQGPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYV 1248
YKRD KL+ ++L + G ++ + R+ + E+++ Q+M KDL + +L +
Sbjct: 368 YKRDLVQKLKILRQELSQQQ--PQAGHCRIEVSREEIFEESYRQVMKMRPKDLWK-RLMI 424
Query: 1249 TFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFR 1308
F GEEGLDY G +RE+ +L+S E+ NPYYGLF+YS +D YT+QI+P SA H +F
Sbjct: 425 KFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFH 484
Query: 1309 FSGRILGLALIHQYLLDAFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDNDIHDI 1368
F GRI+G+A+ H + +D FT PFYK LL L D+E +D + H SL W+ +NDI +
Sbjct: 485 FVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGV 544
Query: 1369 LDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRG 1428
LD TF V +G+I + ELKP G +IPV E+NKKEY+ V WR RG+ Q +L +G
Sbjct: 545 LDHTFCVEHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKG 604
Query: 1429 FYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERF 1488
F EV+ L+ FD +ELEL+I G +ID++DW+ NT + D++IV +WFW AVE F
Sbjct: 605 FNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKVNTRLKHCTPDSNIV-KWFWKAVEFF 663
Query: 1489 NNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPRRFCVEKWGKIT-ALPRAHTCFNRLDLP 1547
+ E+R RLLQFVTG+S +P +GF +L+G+ GPR F + + T LP+AHTCFNR+D+P
Sbjct: 664 DEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIP 723
Query: 1548 PYPSFSMLYEKLLTAVEETSTFGLE 1572
PY S+ LYEKLLTA+EET F +E
Sbjct: 724 PYESYEKLYEKLLTAIEETCGFAVE 748
Score = 73.6 bits (179), Expect = 1e-12
Identities = 65/218 (29%), Positives = 88/218 (40%), Gaps = 48/218 (22%)
Query: 806 DEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLNRRYQS 865
D LP WE R + GRI Y++H+ RTT W+RPT P + Y S
Sbjct: 156 DNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPAS------------------EYSS 197
Query: 866 IRRTMT----NERPEENTNAIDGAGEEADFHQASADFRRENILPHSTSRSRITLLLQSPP 921
R ++ P TN G+ +D A R + H SR L +PP
Sbjct: 198 PGRPLSCFVDENTPISGTNGAT-CGQSSDPRLAERRVRSQR---HRNYMSRTHL--HTPP 251
Query: 922 VKFLISPEFFTVLHSNPSAYRMFTNNTCLKHMI-TKVRRDTHHFERYQHNRDLVGFLNMF 980
P Y T + + T+ T H R RDL N+
Sbjct: 252 --------------DLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVP--RDLS---NIN 292
Query: 981 ANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRL 1018
+ LP GWE+++ G+ +FVDHN+RTT F DPRL
Sbjct: 293 CEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRL 330
Score = 44.3 bits (103), Expect = 0.001
Identities = 25/68 (36%), Positives = 37/68 (54%), Gaps = 2/68 (2%)
Query: 793 PSVRQDVSRYQRVDEA-LPPNWEARIDSHGRIFYVDHVNRTTTWQRP-TAPPAPQVLQRS 850
P V +D+S + LPP WE R + GR+++VDH NRTT + P + VL R
Sbjct: 282 PRVPRDLSNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQ 341
Query: 851 NSIQQMEQ 858
N ++ +Q
Sbjct: 342 NQLKDQQQ 349
Score = 32.7 bits (73), Expect = 2.8
Identities = 12/34 (35%), Positives = 22/34 (64%)
Query: 986 ELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLP 1019
+LP G+E + QG+ +F+ + +T+ DPR+P
Sbjct: 252 DLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVP 285
Score = 31.2 bits (69), Expect = 8.3
Identities = 16/49 (32%), Positives = 24/49 (48%), Gaps = 4/49 (8%)
Query: 986 ELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPLQS----SRPTSALV 1030
+LP GWE + G+ +++H +RTT + P P RP S V
Sbjct: 158 DLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFV 206
>gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [Homo
sapiens]
Length = 757
Score = 360 bits (925), Expect = 5e-99
Identities = 192/424 (45%), Positives = 268/424 (63%), Gaps = 11/424 (2%)
Query: 1153 HALLHPSYCQSPRGSPVSSPQNSPGTQRANARAPAPYKRDFEAKLRNFYRKLETKGYGQG 1212
H + H + P P+ P S G+ Y+RD KL+ +L +
Sbjct: 341 HIMNHQCQLKEP-SQPLPLP--SEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQ--PQ 395
Query: 1213 PGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRE 1272
G ++ + R+ + E+++ QIM KDL++ +L V F GEEGLDY G +RE+ +L+ E
Sbjct: 396 AGHCRIEVSREEIFEESYRQIMKMRPKDLKK-RLMVKFRGEEGLDYGGVAREWLYLLCHE 454
Query: 1273 LFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAFFTRPF 1332
+ NPYYGLF+YS ++ Y +QI+P S+ +H +F F GRI+GLA+ H + ++ FT PF
Sbjct: 455 MLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPF 514
Query: 1333 YKALLRILCDLSDLEYLDEEFHQSLQWMKDNDIHDILDLTFTVNEEVFGQITERELKPGG 1392
YK LL LSDLE +D E H+SL W+ +NDI +LD TF V FG+I + ELKP G
Sbjct: 515 YKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNG 574
Query: 1393 ANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAG 1452
N+PVTE+NKKEY+ V WR RG+ Q +L +GF E++ L+ FD +ELEL+I G
Sbjct: 575 RNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGG 634
Query: 1453 TAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFA 1512
+IDL+DW++NT + D++IV RWFW AVE F+ E+R RLLQFVTG++ +P +GF
Sbjct: 635 LDKIDLNDWKSNTRLKHCVADSNIV-RWFWQAVETFDEERRARLLQFVTGSTRVPLQGFK 693
Query: 1513 SLRGSN---GPRRFCVEKWGKIT-ALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETST 1568
+L+GS GPR F + T LP+AHTCFNR+D+PPY S+ LYEKLLTAVEET
Sbjct: 694 ALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCG 753
Query: 1569 FGLE 1572
F +E
Sbjct: 754 FAVE 757
Score = 47.4 bits (111), Expect = 1e-04
Identities = 19/32 (59%), Positives = 24/32 (75%)
Query: 987 LPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRL 1018
LP GWE++ G+ +FVDHN+RTT F DPRL
Sbjct: 308 LPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL 339
Score = 43.5 bits (101), Expect = 0.002
Identities = 29/100 (29%), Positives = 44/100 (44%), Gaps = 20/100 (20%)
Query: 809 LPPNWEARIDSHGRIFYVDHVNRTTTWQRP------------TAPPAPQVLQRSNSIQQM 856
LPP WE R GRI++VDH NRTT + P P P L S++
Sbjct: 308 LPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDE 367
Query: 857 EQLNRRYQS--------IRRTMTNERPEENTNAIDGAGEE 888
E +RY+ +R ++ ++P+ I+ + EE
Sbjct: 368 ELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREE 407
Score = 33.5 bits (75), Expect = 1.7
Identities = 14/37 (37%), Positives = 23/37 (62%)
Query: 986 ELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPLQS 1022
ELP G+E + QG+ +F+ + +T+ DPR+P S
Sbjct: 235 ELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPS 271
>gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo
sapiens]
Length = 731
Score = 360 bits (925), Expect = 5e-99
Identities = 192/424 (45%), Positives = 268/424 (63%), Gaps = 11/424 (2%)
Query: 1153 HALLHPSYCQSPRGSPVSSPQNSPGTQRANARAPAPYKRDFEAKLRNFYRKLETKGYGQG 1212
H + H + P P+ P S G+ Y+RD KL+ +L +
Sbjct: 315 HIMNHQCQLKEP-SQPLPLP--SEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQ--PQ 369
Query: 1213 PGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRE 1272
G ++ + R+ + E+++ QIM KDL++ +L V F GEEGLDY G +RE+ +L+ E
Sbjct: 370 AGHCRIEVSREEIFEESYRQIMKMRPKDLKK-RLMVKFRGEEGLDYGGVAREWLYLLCHE 428
Query: 1273 LFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAFFTRPF 1332
+ NPYYGLF+YS ++ Y +QI+P S+ +H +F F GRI+GLA+ H + ++ FT PF
Sbjct: 429 MLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPF 488
Query: 1333 YKALLRILCDLSDLEYLDEEFHQSLQWMKDNDIHDILDLTFTVNEEVFGQITERELKPGG 1392
YK LL LSDLE +D E H+SL W+ +NDI +LD TF V FG+I + ELKP G
Sbjct: 489 YKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNG 548
Query: 1393 ANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAG 1452
N+PVTE+NKKEY+ V WR RG+ Q +L +GF E++ L+ FD +ELEL+I G
Sbjct: 549 RNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGG 608
Query: 1453 TAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFA 1512
+IDL+DW++NT + D++IV RWFW AVE F+ E+R RLLQFVTG++ +P +GF
Sbjct: 609 LDKIDLNDWKSNTRLKHCVADSNIV-RWFWQAVETFDEERRARLLQFVTGSTRVPLQGFK 667
Query: 1513 SLRGSN---GPRRFCVEKWGKIT-ALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETST 1568
+L+GS GPR F + T LP+AHTCFNR+D+PPY S+ LYEKLLTAVEET
Sbjct: 668 ALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCG 727
Query: 1569 FGLE 1572
F +E
Sbjct: 728 FAVE 731
Score = 47.4 bits (111), Expect = 1e-04
Identities = 19/32 (59%), Positives = 24/32 (75%)
Query: 987 LPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRL 1018
LP GWE++ G+ +FVDHN+RTT F DPRL
Sbjct: 282 LPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL 313
Score = 46.2 bits (108), Expect = 2e-04
Identities = 58/219 (26%), Positives = 85/219 (38%), Gaps = 41/219 (18%)
Query: 693 PAEGSQESVCTAGSLPVVQVPSGEDEGPGAESATVPDQEELGEVWQRRGSLE---GAAAA 749
P S + G+ V+ PS +D+ A+ PD RGSL+
Sbjct: 181 PYTDSTGAAAGGGNCRFVESPS-QDQRLQAQRLRNPDV---------RGSLQTPQNRPHG 230
Query: 750 AESPPQEEGSAGEAQGTCEGATAQEEGATGGSQANGHQPLRSLPSVRQDVSRYQRVDEAL 809
+SP EG E + T +G TG S + + R L SV D L
Sbjct: 231 HQSPELPEGY--EQRTTVQGQVYFLHTQTGVSTWHDPRIPRDLNSVNCDELG------PL 282
Query: 810 PPNWEARIDSHGRIFYVDHVNRTTTWQRP------------TAPPAPQVLQRSNSIQQME 857
PP WE R GRI++VDH NRTT + P P P L S++ E
Sbjct: 283 PPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDEE 342
Query: 858 QLNRRYQS--------IRRTMTNERPEENTNAIDGAGEE 888
+RY+ +R ++ ++P+ I+ + EE
Sbjct: 343 LPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREE 381
Score = 33.1 bits (74), Expect = 2.2
Identities = 13/34 (38%), Positives = 22/34 (64%)
Query: 986 ELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLP 1019
ELP G+E + QG+ +F+ + +T+ DPR+P
Sbjct: 235 ELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIP 268
>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
Length = 4374
Score = 310 bits (793), Expect = 9e-84
Identities = 163/383 (42%), Positives = 239/383 (62%), Gaps = 5/383 (1%)
Query: 1192 DFEAKLRNFYRKLETKGYGQGPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFV 1251
DF+ K + F ++LE G + + +RRDH+ ED++ ++ S +++ +N+LY+ F
Sbjct: 3993 DFDVKRKYFRQELERLDEGLRKEDMAVHVRRDHVFEDSYRELHRKSPEEM-KNRLYIVFE 4051
Query: 1252 GEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSG 1311
GEEG D G RE++ ++SRE+FNP Y LF S D T I+P S NH +F+F G
Sbjct: 4052 GEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVG 4111
Query: 1312 RILGLALIHQYLLDAFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDNDIHDI-LD 1370
RI+ A+ LL+ +FTR FYK +L +D+E D F+Q L ++ +ND+ + D
Sbjct: 4112 RIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGYD 4171
Query: 1371 LTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFY 1430
LTF+ + FG R+LKP GANI VTE+NKKEY+ + + R+ + +Q + + GFY
Sbjct: 4172 LTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFY 4231
Query: 1431 EVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNN 1490
E++ RL+S+F +ELEL+I+G ID+ D ++NTEY Y N I I+WFW A+ F+
Sbjct: 4232 EIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYH-KYQSNSIQIQWFWRALRSFDQ 4290
Query: 1491 EQRLRLLQFVTGTSSIPYEGFASLRGSNGPRRFCVEKWGKIT-ALPRAHTCFNRLDLPPY 1549
R + LQFVTGTS +P +GFA+L G NG ++F + + + T LP AHTCFN+LDLP Y
Sbjct: 4291 ADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAY 4350
Query: 1550 PSFSMLYEKLLTAVEETST-FGL 1571
SF L LL A++E S FGL
Sbjct: 4351 ESFEKLRHMLLLAIQECSEGFGL 4373
Score = 38.5 bits (88), Expect = 0.052
Identities = 64/270 (23%), Positives = 101/270 (37%), Gaps = 40/270 (14%)
Query: 437 SERSMGASPKLRSSFPTDTRLNAMLHIDSDE-----EDHEFQQDLGYPSSLEEEGGLIMF 491
+E+++ + S+PT +S E + + Q L P +L E +
Sbjct: 2730 TEQNLSDGTPMPDSYPTTPSSTDAATSESKETLGTLQSSQQQPTLPTPPALGE----VPQ 2785
Query: 492 SRASRADDGSLTSQTKLEDNPVENEEASTHEAASFEDKPENLPELAESSLPAGPAPEEGE 551
S A +G ++Q + PVE EE +P E + L PAP
Sbjct: 2786 ELQSPAGEGGSSTQLLM---PVEPEELGP-------TRPSGEAETTQMEL--SPAPTITS 2833
Query: 552 GGPEPQPSADQGSAELCGSQEVDQPTSGADTGTSD-ASGGSRRAVSETESLDQGSEPSQV 610
PE +D +A V G+ TS AS AV +T + +P
Sbjct: 2834 LSPERAEDSDALTA-------VSSQLEGSPMDTSSLASCTLEEAVGDTSAAGSSEQPRAG 2886
Query: 611 SSETEPSDPA------RTESVSEASTRPEGESDLECADSSCNESVTTQLSSVDTRCSSLE 664
SS + PA R++ E++ PE S ++SS +S D+R LE
Sbjct: 2887 SSTPGDAPPAVAEVQGRSDGSGESAQPPEDSSPPASSESSSTRDSAVAISGADSR-GILE 2945
Query: 665 SARFPETPAFSSQEEEDGACAAEPTSSGPA 694
P+ SS+EE+ A + P P+
Sbjct: 2946 E----PLPSTSSEEEDPLAGISLPEGVDPS 2971
>gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiquitin
protein ligase 1 [Homo sapiens]
Length = 909
Score = 265 bits (677), Expect = 3e-70
Identities = 144/348 (41%), Positives = 216/348 (62%), Gaps = 5/348 (1%)
Query: 1218 LIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPY 1277
L++ RD + + + + L++ + V F GEEG+ G RE+F ++S E+ NP
Sbjct: 555 LLVHRDSIFRSSCEVVSKANCAKLKQG-IAVRFHGEEGMG-QGVVREWFDILSNEIVNPD 612
Query: 1278 YGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAFFTRPFYKALL 1337
Y LF SA+ T T Q + S +H +FRF+G+ILGLAL H+ L++ +FTR FYK +L
Sbjct: 613 YALFTQSADGT-TFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHIL 671
Query: 1338 RILCDLSDLEYLDEEFHQSLQWMKDNDIHDI-LDLTFTVNEEVFGQITERELKPGGANIP 1396
I + D+ +D E+ ++LQW+ DNDI D+ L+LTF+V +VFG + E LKPGG +I
Sbjct: 672 GIPVNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSIL 731
Query: 1397 VTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEI 1456
VT+ NK EY++ + + R+ R + Q + ++GF+ + L+ +FD ELEL+++G EI
Sbjct: 732 VTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEI 791
Query: 1457 DLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRG 1516
D+SDW NTEY GY VI+WFW VE E+R+ LLQFVTG+S +P+ GFA++ G
Sbjct: 792 DVSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMG 851
Query: 1517 SNGPRRFCVEKWGKI-TALPRAHTCFNRLDLPPYPSFSMLYEKLLTAV 1563
+G + F + LP + TC N L LP YPS +L ++LL A+
Sbjct: 852 GSGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVAL 899
Score = 32.7 bits (73), Expect = 2.8
Identities = 15/27 (55%), Positives = 19/27 (70%)
Query: 856 MEQLNRRYQSIRRTMTNERPEENTNAI 882
MEQLNR +S+RR T E PE+N A+
Sbjct: 5 MEQLNRLTRSLRRARTVELPEDNETAV 31
>gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]
Length = 872
Score = 190 bits (483), Expect = 8e-48
Identities = 125/366 (34%), Positives = 191/366 (52%), Gaps = 24/366 (6%)
Query: 1216 LKLIIRRDHLLEDAF---NQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRE 1272
L+L +RRDH+++DA I + DL++ +LYV F GE+G+D G S+EFF LV E
Sbjct: 520 LRLKVRRDHIIDDALVRLEMIAMENPADLKK-QLYVEFEGEQGVDEGGVSKEFFQLVVEE 578
Query: 1273 LFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAFFTRPF 1332
+FNP G+F Y + T +P S + F G +LGLA+ + +LD F
Sbjct: 579 IFNPDIGMFTYDES-TKLFWFNPSSFETEGQ---FTLIGIVLGLAIYNNCILDVHFPMVV 634
Query: 1333 YKALLRILCDLSDLEYLDEEFHQSLQWMKD--NDIHDILDLTFTVNE-EVFGQITERELK 1389
Y+ L+ DL +QSL+ + + ++ D + +TF +++ ++FG +LK
Sbjct: 635 YRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLK 694
Query: 1390 PGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVV-DARLVSVFDARELEL 1448
G IP+T +N+KE++ + + + V +Q ++ RGF+ V ++ L +F E+EL
Sbjct: 695 ENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIEL 754
Query: 1449 VIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPY 1508
+I G+ +D TEY GGY + ++IR FW V F +EQ+ LQF TGT P
Sbjct: 755 LICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPV 814
Query: 1509 EGFASLR---GSNGPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEE 1565
G L+ NGP LP +HTCFN L LP Y S L E+LL A+
Sbjct: 815 GGLGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITY 865
Query: 1566 TSTFGL 1571
FG+
Sbjct: 866 AKGFGM 871
>gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]
Length = 852
Score = 190 bits (483), Expect = 8e-48
Identities = 125/366 (34%), Positives = 191/366 (52%), Gaps = 24/366 (6%)
Query: 1216 LKLIIRRDHLLEDAF---NQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRE 1272
L+L +RRDH+++DA I + DL++ +LYV F GE+G+D G S+EFF LV E
Sbjct: 500 LRLKVRRDHIIDDALVRLEMIAMENPADLKK-QLYVEFEGEQGVDEGGVSKEFFQLVVEE 558
Query: 1273 LFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAFFTRPF 1332
+FNP G+F Y + T +P S + F G +LGLA+ + +LD F
Sbjct: 559 IFNPDIGMFTYDES-TKLFWFNPSSFETEGQ---FTLIGIVLGLAIYNNCILDVHFPMVV 614
Query: 1333 YKALLRILCDLSDLEYLDEEFHQSLQWMKD--NDIHDILDLTFTVNE-EVFGQITERELK 1389
Y+ L+ DL +QSL+ + + ++ D + +TF +++ ++FG +LK
Sbjct: 615 YRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLK 674
Query: 1390 PGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVV-DARLVSVFDARELEL 1448
G IP+T +N+KE++ + + + V +Q ++ RGF+ V ++ L +F E+EL
Sbjct: 675 ENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIEL 734
Query: 1449 VIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPY 1508
+I G+ +D TEY GGY + ++IR FW V F +EQ+ LQF TGT P
Sbjct: 735 LICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPV 794
Query: 1509 EGFASLR---GSNGPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEE 1565
G L+ NGP LP +HTCFN L LP Y S L E+LL A+
Sbjct: 795 GGLGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITY 845
Query: 1566 TSTFGL 1571
FG+
Sbjct: 846 AKGFGM 851
>gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]
Length = 875
Score = 190 bits (483), Expect = 8e-48
Identities = 125/366 (34%), Positives = 191/366 (52%), Gaps = 24/366 (6%)
Query: 1216 LKLIIRRDHLLEDAF---NQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRE 1272
L+L +RRDH+++DA I + DL++ +LYV F GE+G+D G S+EFF LV E
Sbjct: 523 LRLKVRRDHIIDDALVRLEMIAMENPADLKK-QLYVEFEGEQGVDEGGVSKEFFQLVVEE 581
Query: 1273 LFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAFFTRPF 1332
+FNP G+F Y + T +P S + F G +LGLA+ + +LD F
Sbjct: 582 IFNPDIGMFTYDES-TKLFWFNPSSFETEGQ---FTLIGIVLGLAIYNNCILDVHFPMVV 637
Query: 1333 YKALLRILCDLSDLEYLDEEFHQSLQWMKD--NDIHDILDLTFTVNE-EVFGQITERELK 1389
Y+ L+ DL +QSL+ + + ++ D + +TF +++ ++FG +LK
Sbjct: 638 YRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLK 697
Query: 1390 PGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVV-DARLVSVFDARELEL 1448
G IP+T +N+KE++ + + + V +Q ++ RGF+ V ++ L +F E+EL
Sbjct: 698 ENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIEL 757
Query: 1449 VIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPY 1508
+I G+ +D TEY GGY + ++IR FW V F +EQ+ LQF TGT P
Sbjct: 758 LICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPV 817
Query: 1509 EGFASLR---GSNGPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEE 1565
G L+ NGP LP +HTCFN L LP Y S L E+LL A+
Sbjct: 818 GGLGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITY 868
Query: 1566 TSTFGL 1571
FG+
Sbjct: 869 AKGFGM 874
>gi|7657152 hect domain and RLD 3 [Homo sapiens]
Length = 1050
Score = 183 bits (465), Expect = 1e-45
Identities = 119/381 (31%), Positives = 193/381 (50%), Gaps = 16/381 (4%)
Query: 1195 AKLRNFYRKLETKGYGQGPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEE 1254
A L+N + L + L L +RR++L+ DA ++ +S DL++ L V F GEE
Sbjct: 681 ANLQNVFMLLTLEPLLARSPFLVLHVRRNNLVGDALRELSIHSDIDLKK-PLKVIFDGEE 739
Query: 1255 GLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRIL 1314
+D G ++EFF L+ +EL NP YG+F Y D+ + S + FV+ H WF G
Sbjct: 740 AVDAGGVTKEFFLLLLKELLNPIYGMFTYY-QDSNLLWFSD-TCFVE--HNWFHLIGITC 795
Query: 1315 GLALIHQYLLDAFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKD---NDIHDILDL 1371
GLA+ + ++D F YK LL + L DL+ L +SLQ + D D+ + L
Sbjct: 796 GLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCL 855
Query: 1372 TFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYE 1431
FT+ E +G I +++L PGG N+ V + N++E+++ V + + V + + GF +
Sbjct: 856 NFTICRESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLK 915
Query: 1432 VVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNE 1491
V +++ +F EL ++ G + + + Y+G Y H ++ FW F E
Sbjct: 916 VCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLE 975
Query: 1492 QRLRLLQFVTGTSSIPYEGFASLRGSNGPRRFCVEKWGK-ITALPRAHTCFNRLDLPPYP 1550
++ + L F+TG+ IP G ASL + ++ LP AHTC+N LDLP Y
Sbjct: 976 KKKKFLLFLTGSDRIPIYGMASL-------QIVIQSTASGEEYLPVAHTCYNLLDLPKYS 1028
Query: 1551 SFSMLYEKLLTAVEETSTFGL 1571
S +L +L A++ F L
Sbjct: 1029 SKEILSARLTQALDNYEGFSL 1049
>gi|190341084 HECT domain containing 2 isoform a [Homo sapiens]
Length = 776
Score = 183 bits (464), Expect = 1e-45
Identities = 123/374 (32%), Positives = 197/374 (52%), Gaps = 31/374 (8%)
Query: 1216 LKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFN 1275
L + +RR HL+ D+ +++ R DL++ KL VTFVGE GLD G ++E+F L+ R++F+
Sbjct: 417 LNMKVRRTHLVSDSLDELTR-KRADLKK-KLKVTFVGEAGLDMGGLTKEWFLLLIRQIFH 474
Query: 1276 PYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAFFTRPFYKA 1335
P YG+F Y D++ S DN+ E FR G ++GLA+ + LD F YK
Sbjct: 475 PDYGMFTYH-KDSHCHWFSSFKC--DNYSE-FRLVGILMGLAVYNSITLDIRFPPCCYKK 530
Query: 1336 LLRI------------LCDLS--DLEYLDEEFHQSLQWM--KDNDIHDILDLTFTVNEEV 1379
LL +C+++ DL + E L + + ++ + TF V +E
Sbjct: 531 LLSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEE 590
Query: 1380 FGQITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVS 1439
FG I LKPGG I VT +N+KEY++ + + + + +Q + GF+ V + +
Sbjct: 591 FGIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALM 650
Query: 1440 VFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQF 1499
+ E+E+++ G+ ++D+ + +T+Y GY + I++FW V F + + +LL F
Sbjct: 651 LLRPEEVEILVCGSPDLDMHALQRSTQY-DGYAKTDLTIKYFWDVVLGFPLDLQKKLLHF 709
Query: 1500 VTGTSSIPYEGFASLRGSNGPRRFCVEKWGKIT-ALPRAHTCFNRLDLPPYPSFSMLYEK 1558
TG+ +P G A L F + K T LP AHTCFN+L LPPY S L +K
Sbjct: 710 TTGSDRVPVGGMADL-------NFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQK 762
Query: 1559 LLTAVEETSTFGLE 1572
L+ + + FGLE
Sbjct: 763 LIIGISNSEGFGLE 776
>gi|35493952 ubiquitin protein ligase E3B [Homo sapiens]
Length = 1068
Score = 182 bits (461), Expect = 3e-45
Identities = 131/393 (33%), Positives = 193/393 (49%), Gaps = 37/393 (9%)
Query: 1213 PGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVG-----EEGLDYSGPSREFFF 1267
P + IRR +LED + Q+ S+ + + + V FV E G+D G +EF
Sbjct: 678 PHVTHITIRRSRMLEDGYEQLRQLSQHAM-KGVIRVKFVNDLGVDEAGIDQDGVFKEFLE 736
Query: 1268 LVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAF 1327
+ + +F+P LF+ ++ D + SP S +N+ + F F G++LG A+ ++D
Sbjct: 737 EIIKRVFDPALNLFKTTSGDE-RLYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVP 795
Query: 1328 FTRPFYKALLR-----ILCDLSDLEYLDEEFHQSLQWMK--DNDIHDILDLTFTVNEEVF 1380
F F LL + +L LD EF+++L +K D DI D L LT + +E+V
Sbjct: 796 FASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITD-LGLTLSYDEDVM 854
Query: 1381 GQITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSV 1440
GQ+ EL PGG IPVT +NK YI M +R+ + QT +L+ GF ++ + +
Sbjct: 855 GQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRM 914
Query: 1441 FDARELELVIAG-TAEIDLSDWRNNTEYRGGYHDNHIVIRWFW-AAVERFNNEQRLRLLQ 1498
F EL+ +I+G AEIDL D + +T Y GG+H +H VI W W F ++R L+
Sbjct: 915 FSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERAMFLK 974
Query: 1499 FVTGTSSIPYEGFASLR--------------------GSNGPRRFCVEKWGKITALPRAH 1538
FVT S P GFA L+ GS F + K LP +
Sbjct: 975 FVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSS 1034
Query: 1539 TCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGL 1571
TCFN L LP Y S+L EKL A+ + F L
Sbjct: 1035 TCFNLLKLPNYSKKSVLREKLRYAISMNTGFEL 1067
>gi|35493959 ubiquitin protein ligase E3B [Homo sapiens]
Length = 1068
Score = 182 bits (461), Expect = 3e-45
Identities = 131/393 (33%), Positives = 193/393 (49%), Gaps = 37/393 (9%)
Query: 1213 PGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVG-----EEGLDYSGPSREFFF 1267
P + IRR +LED + Q+ S+ + + + V FV E G+D G +EF
Sbjct: 678 PHVTHITIRRSRMLEDGYEQLRQLSQHAM-KGVIRVKFVNDLGVDEAGIDQDGVFKEFLE 736
Query: 1268 LVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAF 1327
+ + +F+P LF+ ++ D + SP S +N+ + F F G++LG A+ ++D
Sbjct: 737 EIIKRVFDPALNLFKTTSGDE-RLYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVP 795
Query: 1328 FTRPFYKALLR-----ILCDLSDLEYLDEEFHQSLQWMK--DNDIHDILDLTFTVNEEVF 1380
F F LL + +L LD EF+++L +K D DI D L LT + +E+V
Sbjct: 796 FASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITD-LGLTLSYDEDVM 854
Query: 1381 GQITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSV 1440
GQ+ EL PGG IPVT +NK YI M +R+ + QT +L+ GF ++ + +
Sbjct: 855 GQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRM 914
Query: 1441 FDARELELVIAG-TAEIDLSDWRNNTEYRGGYHDNHIVIRWFW-AAVERFNNEQRLRLLQ 1498
F EL+ +I+G AEIDL D + +T Y GG+H +H VI W W F ++R L+
Sbjct: 915 FSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERAMFLK 974
Query: 1499 FVTGTSSIPYEGFASLR--------------------GSNGPRRFCVEKWGKITALPRAH 1538
FVT S P GFA L+ GS F + K LP +
Sbjct: 975 FVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSS 1034
Query: 1539 TCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGL 1571
TCFN L LP Y S+L EKL A+ + F L
Sbjct: 1035 TCFNLLKLPNYSKKSVLREKLRYAISMNTGFEL 1067
>gi|87116668 hypothetical protein LOC9870 [Homo sapiens]
Length = 823
Score = 180 bits (457), Expect = 8e-45
Identities = 128/387 (33%), Positives = 202/387 (52%), Gaps = 24/387 (6%)
Query: 1193 FEAKLRNFYRKLETKGYGQGPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVG 1252
F+ K+ F R+L + K+ L + R LLE + +S D +N V F
Sbjct: 439 FQDKVNFFQRELRQVHMKRPHSKVTLKVSRHALLESSLKATRNFSISDWSKN-FEVVFQD 497
Query: 1253 EEGLDYSGPSREFFFLVSRELFNPYYGLF-EYSANDTYTVQISPMSAFVDNHHEWFRFSG 1311
EE LD+ GP RE+F L+ + LF+ LF +S N+ V +P + + F+G
Sbjct: 498 EEALDWGGPRREWFELICKALFDTTNQLFTRFSDNNQALVHPNPNRP-AHLRLKMYEFAG 556
Query: 1312 RILGLALI-------HQYLLDAFFTRPFYKALLRILCDLSDLEYLDEEFHQS-LQWMKDN 1363
R++G L ++ L+ A FTR F ++ + E D EF++S + ++ +N
Sbjct: 557 RLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFILNN 616
Query: 1364 DIHDILDLTFTVNEEVF---GQITER-ELKPGGANIPVTEKNKKEYIERMVKWRIERGVV 1419
D+ + ++L F EE + GQ+ + EL GGA PVT NK Y+ + ++R+ V
Sbjct: 617 DMSE-MELVFA--EEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRLASQVK 673
Query: 1420 QQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGG-YHDNHIVI 1478
++ E ++G E+V L+++FD ELEL++ GT +I +SD++ + GG +H V+
Sbjct: 674 EEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHFREKVM 733
Query: 1479 RWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPRRFCVEKWGKITALPRAH 1538
RWFW V E+ RLLQF TG+S +P GFA+L S F + + LP AH
Sbjct: 734 RWFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAALCPS-----FQIIAAPTHSTLPTAH 788
Query: 1539 TCFNRLDLPPYPSFSMLYEKLLTAVEE 1565
TCFN+L LP Y S+ ++ L A+ E
Sbjct: 789 TCFNQLCLPTYDSYEEVHRMLQLAISE 815
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.131 0.385
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 65,988,574
Number of Sequences: 37866
Number of extensions: 3315083
Number of successful extensions: 14389
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 107
Number of HSP's successfully gapped in prelim test: 618
Number of HSP's that attempted gapping in prelim test: 11819
Number of HSP's gapped (non-prelim): 2571
length of query: 1572
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1456
effective length of database: 13,855,062
effective search space: 20172970272
effective search space used: 20172970272
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.