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Search of human proteins with 5453607
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5453607 chaperonin containing TCP1, subunit 7 isoform a
[Homo sapiens]
(543 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5453607 chaperonin containing TCP1, subunit 7 isoform a [Homo... 1062 0.0
gi|58331185 chaperonin containing TCP1, subunit 7 isoform b [Hom... 677 0.0
gi|57863257 T-complex protein 1 isoform a [Homo sapiens] 302 6e-82
gi|5453603 chaperonin containing TCP1, subunit 2 [Homo sapiens] 297 1e-80
gi|38455427 chaperonin containing TCP1, subunit 4 (delta) [Homo ... 297 2e-80
gi|63162572 chaperonin containing TCP1, subunit 3 isoform a [Hom... 290 2e-78
gi|58761486 chaperonin containing TCP1, subunit 3 isoform b [Hom... 284 1e-76
gi|24307939 chaperonin containing TCP1, subunit 5 (epsilon) [Hom... 258 7e-69
gi|58761484 chaperonin containing TCP1, subunit 3 isoform c [Hom... 245 9e-65
gi|4502643 chaperonin containing TCP1, subunit 6A isoform a [Hom... 236 4e-62
gi|58331173 chaperonin containing TCP1, subunit 6B [Homo sapiens] 233 4e-61
gi|48762932 chaperonin containing TCP1, subunit 8 (theta) [Homo ... 206 3e-53
gi|57863259 T-complex protein 1 isoform b [Homo sapiens] 189 4e-48
gi|58331171 chaperonin containing TCP1, subunit 6A isoform b [Ho... 179 8e-45
gi|7657253 T-complex protein 1 [Homo sapiens] 129 9e-30
gi|41399285 chaperonin [Homo sapiens] 77 5e-14
gi|31542947 chaperonin [Homo sapiens] 77 5e-14
gi|121583483 phosphatidylinositol-3-phosphate 5-kinase type III ... 52 2e-06
gi|100816407 Bardet-Biedl syndrome 10 [Homo sapiens] 47 6e-05
gi|9055272 McKusick-Kaufman syndrome protein [Homo sapiens] 40 0.005
gi|25914754 McKusick-Kaufman syndrome protein [Homo sapiens] 40 0.005
gi|115527097 CDC42-binding protein kinase beta [Homo sapiens] 32 1.5
gi|40217788 Bardet-Biedl syndrome 12 [Homo sapiens] 32 1.9
gi|24234690 meiotic recombination 11 homolog A isoform 2 [Homo s... 31 3.3
gi|5031923 meiotic recombination 11 homolog A isoform 1 [Homo sa... 31 3.3
gi|226437568 apoptosis-inducing factor, mitochondrion-associated... 30 5.6
gi|65787454 apoptosis-inducing factor, mitochondrion-associated,... 30 5.6
gi|21389617 apoptosis-inducing factor, mitochondrion-associated,... 30 5.6
gi|51558724 ADAM metallopeptidase with thrombospondin type 1 mot... 30 5.6
gi|115527120 nebulin [Homo sapiens] 30 7.4
>gi|5453607 chaperonin containing TCP1, subunit 7 isoform a [Homo
sapiens]
Length = 543
Score = 1062 bits (2747), Expect = 0.0
Identities = 543/543 (100%), Positives = 543/543 (100%)
Query: 1 MMPTPVILLKEGTDSSQGIPQLVSNISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISN 60
MMPTPVILLKEGTDSSQGIPQLVSNISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISN
Sbjct: 1 MMPTPVILLKEGTDSSQGIPQLVSNISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISN 60
Query: 61 DGATILKLLDVVHPAAKTLVDIAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQI 120
DGATILKLLDVVHPAAKTLVDIAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQI
Sbjct: 61 DGATILKLLDVVHPAAKTLVDIAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQI 120
Query: 121 IIRAFRTATQLAVNKIKEIAVTVKKADKVEQRKLLEKCAMTALSSKLISQQKAFFAKMVV 180
IIRAFRTATQLAVNKIKEIAVTVKKADKVEQRKLLEKCAMTALSSKLISQQKAFFAKMVV
Sbjct: 121 IIRAFRTATQLAVNKIKEIAVTVKKADKVEQRKLLEKCAMTALSSKLISQQKAFFAKMVV 180
Query: 181 DAVMMLDDLLQLKMIGIKKVQGGALEDSQLVAGVAFKKTFSYAGFEMQPKKYHNPKIALL 240
DAVMMLDDLLQLKMIGIKKVQGGALEDSQLVAGVAFKKTFSYAGFEMQPKKYHNPKIALL
Sbjct: 181 DAVMMLDDLLQLKMIGIKKVQGGALEDSQLVAGVAFKKTFSYAGFEMQPKKYHNPKIALL 240
Query: 241 NVELELKAEKDNAEIRVHTVEDYQAIVDAEWNILYDKLEKIHHSGAKVVLSKLPIGDVAT 300
NVELELKAEKDNAEIRVHTVEDYQAIVDAEWNILYDKLEKIHHSGAKVVLSKLPIGDVAT
Sbjct: 241 NVELELKAEKDNAEIRVHTVEDYQAIVDAEWNILYDKLEKIHHSGAKVVLSKLPIGDVAT 300
Query: 301 QYFADRDMFCAGRVPEEDLKRTMMACGGSIQTSVNALSADVLGRCQVFEETQIGGERYNF 360
QYFADRDMFCAGRVPEEDLKRTMMACGGSIQTSVNALSADVLGRCQVFEETQIGGERYNF
Sbjct: 301 QYFADRDMFCAGRVPEEDLKRTMMACGGSIQTSVNALSADVLGRCQVFEETQIGGERYNF 360
Query: 361 FTGCPKAKTCTFILRGGAEQFMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYL 420
FTGCPKAKTCTFILRGGAEQFMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYL
Sbjct: 361 FTGCPKAKTCTFILRGGAEQFMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYL 420
Query: 421 RDYSRTIPGKQQLLIGAYAKALEIIPRQLCDNAGFDATNILNKLRARHAQGGTWYGVDIN 480
RDYSRTIPGKQQLLIGAYAKALEIIPRQLCDNAGFDATNILNKLRARHAQGGTWYGVDIN
Sbjct: 421 RDYSRTIPGKQQLLIGAYAKALEIIPRQLCDNAGFDATNILNKLRARHAQGGTWYGVDIN 480
Query: 481 NEDIADNFEAFVWEPAMVRINALTAASEAACLIVSVDETIKNPRSTVDAPTAAGRGRGRG 540
NEDIADNFEAFVWEPAMVRINALTAASEAACLIVSVDETIKNPRSTVDAPTAAGRGRGRG
Sbjct: 481 NEDIADNFEAFVWEPAMVRINALTAASEAACLIVSVDETIKNPRSTVDAPTAAGRGRGRG 540
Query: 541 RPH 543
RPH
Sbjct: 541 RPH 543
>gi|58331185 chaperonin containing TCP1, subunit 7 isoform b [Homo
sapiens]
Length = 339
Score = 677 bits (1746), Expect = 0.0
Identities = 337/337 (100%), Positives = 337/337 (100%)
Query: 207 DSQLVAGVAFKKTFSYAGFEMQPKKYHNPKIALLNVELELKAEKDNAEIRVHTVEDYQAI 266
DSQLVAGVAFKKTFSYAGFEMQPKKYHNPKIALLNVELELKAEKDNAEIRVHTVEDYQAI
Sbjct: 3 DSQLVAGVAFKKTFSYAGFEMQPKKYHNPKIALLNVELELKAEKDNAEIRVHTVEDYQAI 62
Query: 267 VDAEWNILYDKLEKIHHSGAKVVLSKLPIGDVATQYFADRDMFCAGRVPEEDLKRTMMAC 326
VDAEWNILYDKLEKIHHSGAKVVLSKLPIGDVATQYFADRDMFCAGRVPEEDLKRTMMAC
Sbjct: 63 VDAEWNILYDKLEKIHHSGAKVVLSKLPIGDVATQYFADRDMFCAGRVPEEDLKRTMMAC 122
Query: 327 GGSIQTSVNALSADVLGRCQVFEETQIGGERYNFFTGCPKAKTCTFILRGGAEQFMEETE 386
GGSIQTSVNALSADVLGRCQVFEETQIGGERYNFFTGCPKAKTCTFILRGGAEQFMEETE
Sbjct: 123 GGSIQTSVNALSADVLGRCQVFEETQIGGERYNFFTGCPKAKTCTFILRGGAEQFMEETE 182
Query: 387 RSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYLRDYSRTIPGKQQLLIGAYAKALEIIP 446
RSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYLRDYSRTIPGKQQLLIGAYAKALEIIP
Sbjct: 183 RSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYLRDYSRTIPGKQQLLIGAYAKALEIIP 242
Query: 447 RQLCDNAGFDATNILNKLRARHAQGGTWYGVDINNEDIADNFEAFVWEPAMVRINALTAA 506
RQLCDNAGFDATNILNKLRARHAQGGTWYGVDINNEDIADNFEAFVWEPAMVRINALTAA
Sbjct: 243 RQLCDNAGFDATNILNKLRARHAQGGTWYGVDINNEDIADNFEAFVWEPAMVRINALTAA 302
Query: 507 SEAACLIVSVDETIKNPRSTVDAPTAAGRGRGRGRPH 543
SEAACLIVSVDETIKNPRSTVDAPTAAGRGRGRGRPH
Sbjct: 303 SEAACLIVSVDETIKNPRSTVDAPTAAGRGRGRGRPH 339
>gi|57863257 T-complex protein 1 isoform a [Homo sapiens]
Length = 556
Score = 302 bits (773), Expect = 6e-82
Identities = 192/537 (35%), Positives = 294/537 (54%), Gaps = 28/537 (5%)
Query: 14 DSSQGIPQLVSNISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISNDGATILKLLDVVH 73
D S G N+ A IA V+++LGP G+DK++VD G TI+NDGATILKLL+V H
Sbjct: 10 DRSTGETIRSQNVMAAASIANIVKSSLGPVGLDKMLVDDIGDVTITNDGATILKLLEVEH 69
Query: 74 PAAKTLVDIAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAFRTATQLAV 133
PAAK L ++A QD EVGDGTTSV ++AAE LK V++ +HP +I +R A + AV
Sbjct: 70 PAAKVLCELADLQDKEVGDGTTSVVIIAAELLKNADELVKQKIHPTSVISGYRLACKEAV 129
Query: 134 NKIKEIAVTVKKADKVEQRKLLEKCAMTALSSKLISQQKAFFAKMVVDAVMML------- 186
I E + D++ R L A T++SSK+I FFA MVVDAV+ +
Sbjct: 130 RYINENLIV--NTDEL-GRDCLINAAKTSMSSKIIGINGDFFANMVVDAVLAIKYTDIRG 186
Query: 187 DDLLQLKMIGIKKVQGGALEDSQLVAGVAFKKTFSYAGFEMQPKKYHNPKIALLNVELEL 246
+ + I K G + +S L++G A G + PK+ N KIA L+ L+
Sbjct: 187 QPRYPVNSVNILKAHGRSQMESMLISGYALN---CVVGSQGMPKRIVNAKIACLDFSLQK 243
Query: 247 KAEKDNAEIRVHTVEDYQAIVDAEWNILYDKLEKIHHSGAKVVLSKLPIGDVATQYFADR 306
K ++ + E I E +I ++++KI +GA V+L+ I D+ +YF +
Sbjct: 244 TKMKLGVQVVITDPEKLDQIRQRESDITKERIQKILATGANVILTTGGIDDMCLKYFVEA 303
Query: 307 DMFCAGRVPEEDLKRTMMACGGSIQTSV------NALSADVLGRCQVFEETQIGGERYNF 360
RV + DLKR A G +I +++ A +LG+ + + +I +
Sbjct: 304 GAMAVRRVLKRDLKRIAKASGATILSTLANLEGEETFEAAMLGQAEEVVQERICDDELIL 363
Query: 361 FTGCPKAKTCTFILRGGAEQFMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYL 420
+ + ILRG + +E ERSLHDA+ +V+R +++ SVV GGGA+E LS YL
Sbjct: 364 IKNTKARTSASIILRGANDFMCDEMERSLHDALCVVKRVLESKSVVPGGGAVEAALSIYL 423
Query: 421 RDYSRTIPGKQQLLIGAYAKALEIIPRQLCDNAGFDATNILNKLRARHAQGGT------- 473
+Y+ ++ ++QL I +A++L +IP L NA D+T+++ KLRA H +
Sbjct: 424 ENYATSMGSREQLAIAEFARSLLVIPNTLAVNAAQDSTDLVAKLRAFHNEAQVNPERKNL 483
Query: 474 -WYGVDINNEDIADNFEAFVWEPAMVRINALTAASEAACLIVSVDETIK-NPRSTVD 528
W G+D++N DN +A V+EP +V++ +L A+EAA I+ +D+ IK +P S D
Sbjct: 484 KWIGLDLSNGKPRDNKQAGVFEPTIVKVKSLKFATEAAITILRIDDLIKLHPESKDD 540
>gi|5453603 chaperonin containing TCP1, subunit 2 [Homo sapiens]
Length = 535
Score = 297 bits (761), Expect = 1e-80
Identities = 183/527 (34%), Positives = 290/527 (55%), Gaps = 9/527 (1%)
Query: 5 PVILLKEGTDSSQGIPQLVSNISACQVIAEAVRTTLGPRGMDKLIVDGRGKAT--ISNDG 62
PV + K G D + +++ I + V++TLGP+GMDK+++ A+ ++NDG
Sbjct: 8 PVNIFKAGADEERAETARLTSFIGAIAIGDLVKSTLGPKGMDKILLSSGRDASLMVTNDG 67
Query: 63 ATILKLLDVVHPAAKTLVDIAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIII 122
ATILK + V +PAAK LVD+++ QD EVGDGTTSVT+LAAE L++ + + + +HPQ II
Sbjct: 68 ATILKNIGVDNPAAKVLVDMSRVQDDEVGDGTTSVTVLAAELLREAESLIAKKIHPQTII 127
Query: 123 RAFRTATQLAVNKIKEIAVTVKKADKVEQRKLLEKCAMTALSSKLISQQKAFFAKMVVDA 182
+R AT+ A + AV +D+V+ R+ L A T LSSKL++ K F K+ V+A
Sbjct: 128 AGWREATKAAREALLSSAVD-HGSDEVKFRQDLMNIAGTTLSSKLLTHHKDHFTKLAVEA 186
Query: 183 VMMLDDLLQLKMIGIKKVQGGALEDSQLVAGVAFKKTFSYAGFEMQPKKYHNPKIALLNV 242
V+ L L+ I I K GG+L DS L G K QPK+ N KI + N
Sbjct: 187 VLRLKGSGNLEAIHIIKKLGGSLADSYLDEGFLLDKKIGVN----QPKRIENAKILIANT 242
Query: 243 ELEL-KAEKDNAEIRVHTVEDYQAIVDAEWNILYDKLEKIHHSGAKVVLSKLPIGDVATQ 301
++ K + + +RV + I AE + +K+E+I G +++ I + Q
Sbjct: 243 GMDTDKIKIFGSRVRVDSTAKVAEIEHAEKEKMKEKVERILKHGINCFINRQLIYNYPEQ 302
Query: 302 YFADRDMFCAGRVPEEDLKRTMMACGGSIQTSVNALSADVLGRCQVFEETQIGGERYNFF 361
F + ++R + GG I ++ + LG C++ EE IG ++ F
Sbjct: 303 LFGAAGVMAIEHADFAGVERLALVTGGEIASTFDHPELVKLGSCKLIEEVMIGEDKLIHF 362
Query: 362 TGCPKAKTCTFILRGGAEQFMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYLR 421
+G + CT +LRG +Q ++E ERSLHDA+ ++ + +K+ V GGG EM ++ +
Sbjct: 363 SGVALGEACTIVLRGATQQILDEAERSLHDALCVLAQTVKDSRTVYGGGCSEMLMAHAVT 422
Query: 422 DYSRTIPGKQQLLIGAYAKALEIIPRQLCDNAGFDATNILNKLRARHAQGGTWYGVDINN 481
+ PGK+ + + +YAKAL ++P + DNAG+D+ +++ +LRA H++G T G+D+
Sbjct: 423 QLANRTPGKEAVAMESYAKALRMLPTIIADNAGYDSADLVAQLRAAHSEGNTTAGLDMRE 482
Query: 482 EDIADNFEAFVWEPAMVRINALTAASEAACLIVSVDETIK-NPRSTV 527
I D + E V+ L +A+EAA +I+ VD IK PR V
Sbjct: 483 GTIGDMAILGITESFQVKRQVLLSAAEAAEVILRVDNIIKAAPRKRV 529
>gi|38455427 chaperonin containing TCP1, subunit 4 (delta) [Homo
sapiens]
Length = 539
Score = 297 bits (760), Expect = 2e-80
Identities = 177/510 (34%), Positives = 290/510 (56%), Gaps = 22/510 (4%)
Query: 24 SNISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISNDGATILKLLDVVHPAAKTLVDIA 83
SNISA + +A+A+RT+LGP+GMDK+I DG+G TI+NDGATILK + V+HPAA+ LV+++
Sbjct: 36 SNISAAKAVADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQMQVLHPAARMLVELS 95
Query: 84 KSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAFRTATQLAVNKIKEIAVTV 143
K+QD E GDGTTSV ++A L +++G+HP II +F Q A+ K EI +
Sbjct: 96 KAQDIEAGDGTTSVVIIAGSLLDSCTKLLQKGIHPTIISESF----QKALEKGIEILTDM 151
Query: 144 KKADKVEQRKLLEKCAMTALSSKLISQQKAFFAKMVVDAVMMLDD-----LLQLKMIGIK 198
+ ++ R+ L A T+L+SK++SQ + + M V+AVM + D + L+ I I
Sbjct: 152 SRPVELSDRETLLNSATTSLNSKVVSQYSSLLSPMSVNAVMKVIDPATATSVDLRDIKIV 211
Query: 199 KVQGGALEDSQLVAGVAFKKTFSYAGFEMQPKKYHNPKIALLNVELEL-KAEKDNAEIRV 257
K GG ++D +LV G+ + S +G + KI L+ L K + DN +I V
Sbjct: 212 KKLGGTIDDCELVEGLVLTQKVSNSGI----TRVEKAKIGLIQFCLSAPKTDMDN-QIVV 266
Query: 258 HTVEDYQAIVDAEWNILYDKLEKIHHSGAKVVLSKLPI-----GDVATQYFADRDMFCAG 312
++ E + + +++I +G V+L + I D+A + +
Sbjct: 267 SDYAQMDRVLREERAYILNLVKQIKKTGCNVLLIQKSILRDALSDLALHFLNKMKIMVIK 326
Query: 313 RVPEEDLKRTMMACGGSIQTSVNALSADVLGRCQVFEETQIGGE-RYNFFTGCPK-AKTC 370
+ ED++ G ++ +AD+LG ++ EE + G + TGC KT
Sbjct: 327 DIEREDIEFICKTIGTKPVAHIDQFTADMLGSAELAEEVNLNGSGKLLKITGCASPGKTV 386
Query: 371 TFILRGGAEQFMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYLRDYSRTIPGK 430
T ++RG + +EE ERS+HDA+ ++R +K +++AGGGA E+EL+ L +YSRT+ G
Sbjct: 387 TIVVRGSNKLVIEEAERSIHDALCVIRCLVKKRALIAGGGAPEIELALRLTEYSRTLSGM 446
Query: 431 QQLLIGAYAKALEIIPRQLCDNAGFDATNILNKLRARHAQGGTWYGVDINNEDIADNFEA 490
+ + A+A A+E+IP L +NAG + + + +LR RHAQG G+++ I++ E
Sbjct: 447 ESYCVRAFADAMEVIPSTLAENAGLNPISTVTELRNRHAQGEKTAGINVRKGGISNILEE 506
Query: 491 FVWEPAMVRINALTAASEAACLIVSVDETI 520
V +P +V ++ALT A+E I+ +D+ +
Sbjct: 507 LVVQPLLVSVSALTLATETVRSILKIDDVV 536
>gi|63162572 chaperonin containing TCP1, subunit 3 isoform a [Homo
sapiens]
Length = 545
Score = 290 bits (743), Expect = 2e-78
Identities = 173/547 (31%), Positives = 287/547 (52%), Gaps = 18/547 (3%)
Query: 5 PVILLKEGTDSSQGIPQLVSNISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISNDGAT 64
PV++L + T G NI+A + IA+ +RT LGP+ M K+++D G ++NDG
Sbjct: 6 PVLVLSQNTKRESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNA 65
Query: 65 ILKLLDVVHPAAKTLVDIAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRA 124
IL+ + V HPAAK++++I+++QD EVGDGTTSV +LA E L + ++E+ +HP ++I A
Sbjct: 66 ILREIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVISA 125
Query: 125 FRTATQLAVNKIKEIAVTVKKADKVEQRKLLEKCAMTALSSKLISQQKAFFAKMVVDAVM 184
+R A ++ +K+I++ V +D ++ +++++K IS+ + + +DAV
Sbjct: 126 YRKALDDMISTLKKISIPVDISDSDMMLNIIN----SSITTKAISRWSSLACNIALDAVK 181
Query: 185 MLD-------DLLQLKMIGIKKVQGGALEDSQLVAGVAFKKTFSYAGFEMQPKKYHNPKI 237
M+ ++ K ++K+ GG +EDS ++ GV K ++ K NP+I
Sbjct: 182 MVQFEENGRKEIDIKKYARVEKIPGGIIEDSCVLRGVMINKDVTHPRMRRYIK---NPRI 238
Query: 238 ALLNVELELKAEKDNAEIRVHTVEDYQAIVDAEWNILYDKLEKIHHSGAKVVLSKLPIGD 297
LL+ LE K + +I + ED+ I+ E + E I VV+++ I D
Sbjct: 239 VLLDSSLEYKKGESQTDIEITREEDFTRILQMEEEYIQQLCEDIIQLKPDVVITEKGISD 298
Query: 298 VATQYFADRDMFCAGRVPEEDLKRTMMACGGSIQTSVNALSADVLGR-CQVFEETQIGGE 356
+A Y ++ RV + D R ACG I + L D +G + E +IG E
Sbjct: 299 LAQHYLMRANITAIRRVRKTDNNRIARACGARIVSRPEELREDDVGTGAGLLEIKKIGDE 358
Query: 357 RYNFFTGCPKAKTCTFILRGGAEQFMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMEL 416
+ F T C K CT +LRG +++ + E ER+L DA+ + R + + +V GGGA EM +
Sbjct: 359 YFTFITDCKDPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAV 418
Query: 417 SKYLRDYSRTIPGKQQLLIGAYAKALEIIPRQLCDNAGFDATNILNKLRARHAQGG--TW 474
+ L + S+ + G +Q A A+ALE+IPR L N G +L LRA+H Q TW
Sbjct: 419 AHALTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQENCETW 478
Query: 475 YGVDINNEDIADNFEAFVWEPAMVRINALTAASEAACLIVSVDETIKNPRSTVDAPTAAG 534
GV+ + D E +WEP V++ A E A L++ +D+ + + D + G
Sbjct: 479 -GVNGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIVSGHKKKGDDQSRQG 537
Query: 535 RGRGRGR 541
G+
Sbjct: 538 GAPDAGQ 544
>gi|58761486 chaperonin containing TCP1, subunit 3 isoform b [Homo
sapiens]
Length = 544
Score = 284 bits (727), Expect = 1e-76
Identities = 172/547 (31%), Positives = 286/547 (52%), Gaps = 19/547 (3%)
Query: 5 PVILLKEGTDSSQGIPQLVSNISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISNDGAT 64
PV++L + T G NI+A + IA+ +RT LGP+ M K+++D G ++NDG
Sbjct: 6 PVLVLSQNTKRESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNA 65
Query: 65 ILKLLDVVHPAAKTLVDIAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRA 124
IL+ + V HPAAK++++I+++QD EVGDGTTSV +L E L + ++E+ +HP ++I A
Sbjct: 66 ILREIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILG-EMLSVAEHFLEQQMHPTVVISA 124
Query: 125 FRTATQLAVNKIKEIAVTVKKADKVEQRKLLEKCAMTALSSKLISQQKAFFAKMVVDAVM 184
+R A ++ +K+I++ V +D ++ +++++K IS+ + + +DAV
Sbjct: 125 YRKALDDMISTLKKISIPVDISDSDMMLNIIN----SSITTKAISRWSSLACNIALDAVK 180
Query: 185 MLD-------DLLQLKMIGIKKVQGGALEDSQLVAGVAFKKTFSYAGFEMQPKKYHNPKI 237
M+ ++ K ++K+ GG +EDS ++ GV K ++ K NP+I
Sbjct: 181 MVQFEENGRKEIDIKKYARVEKIPGGIIEDSCVLRGVMINKDVTHPRMRRYIK---NPRI 237
Query: 238 ALLNVELELKAEKDNAEIRVHTVEDYQAIVDAEWNILYDKLEKIHHSGAKVVLSKLPIGD 297
LL+ LE K + +I + ED+ I+ E + E I VV+++ I D
Sbjct: 238 VLLDSSLEYKKGESQTDIEITREEDFTRILQMEEEYIQQLCEDIIQLKPDVVITEKGISD 297
Query: 298 VATQYFADRDMFCAGRVPEEDLKRTMMACGGSIQTSVNALSADVLGR-CQVFEETQIGGE 356
+A Y ++ RV + D R ACG I + L D +G + E +IG E
Sbjct: 298 LAQHYLMRANITAIRRVRKTDNNRIARACGARIVSRPEELREDDVGTGAGLLEIKKIGDE 357
Query: 357 RYNFFTGCPKAKTCTFILRGGAEQFMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMEL 416
+ F T C K CT +LRG +++ + E ER+L DA+ + R + + +V GGGA EM +
Sbjct: 358 YFTFITDCKDPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAV 417
Query: 417 SKYLRDYSRTIPGKQQLLIGAYAKALEIIPRQLCDNAGFDATNILNKLRARHAQGG--TW 474
+ L + S+ + G +Q A A+ALE+IPR L N G +L LRA+H Q TW
Sbjct: 418 AHALTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQENCETW 477
Query: 475 YGVDINNEDIADNFEAFVWEPAMVRINALTAASEAACLIVSVDETIKNPRSTVDAPTAAG 534
GV+ + D E +WEP V++ A E A L++ +D+ + + D + G
Sbjct: 478 -GVNGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIVSGHKKKGDDQSRQG 536
Query: 535 RGRGRGR 541
G+
Sbjct: 537 GAPDAGQ 543
>gi|24307939 chaperonin containing TCP1, subunit 5 (epsilon) [Homo
sapiens]
Length = 541
Score = 258 bits (660), Expect = 7e-69
Identities = 157/526 (29%), Positives = 286/526 (54%), Gaps = 14/526 (2%)
Query: 5 PVILLKEGTDSSQ--GIPQLVSNISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISNDG 62
P +++K+ S+ G+ L S+I A + +A +RT+LGP G+DK++VD G T++NDG
Sbjct: 15 PFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDG 74
Query: 63 ATILKLLDVVHPAAKTLVDIAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIII 122
ATIL ++DV H AK +V+++KSQD E+GDGTT V +LA L++ + ++ G+HP I
Sbjct: 75 ATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIA 134
Query: 123 RAFRTATQLAVNKIKEIAVTVKKADKVEQRKLLEKCAMTALSSKLISQQKAFFAKMVVDA 182
+ A ++A+ + +I+ +V ++ + L + A T L SK+++ A++ V+A
Sbjct: 135 DGYEQAARVAIEHLDKISDSV--LVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNA 192
Query: 183 VMMLDDL----LQLKMIGIKKVQGGALEDSQLVAGVAFKKTFSYAGFEMQPKKYHNPKIA 238
V+ + D+ + ++I ++ GG LED++L+ GV K FS+ PKK + KIA
Sbjct: 193 VLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSH---PQMPKKVEDAKIA 249
Query: 239 LLNVELELKAEKDNAEIRVHTVEDYQAIVDAEWNILYDKLEKIHHSGAKVVLSKLPIGDV 298
+L E K ++ V +VEDY+A+ E + +++I +GA + + + D
Sbjct: 250 ILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDE 309
Query: 299 ATQYFADRDMFCAGRVPEEDLKRTMMACGGSIQTSVNALSADVLGRCQVFEETQIG--GE 356
A ++ V +++ +A GG I + L+A+ LG + +E G +
Sbjct: 310 ANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKD 369
Query: 357 RYNFFTGCPKAKTCTFILRGGAEQFMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMEL 416
+ C ++ T +RGG + +EE +RSLHDA+ ++R I+++ VV GGGA E+
Sbjct: 370 KMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISC 429
Query: 417 SKYLRDYSRTIPGKQQLLIGAYAKALEIIPRQLCDNAGFDATNILNKLRARHA-QGGTWY 475
+ + + P +Q + A+A ALE+IP L +N+G + + ++RAR +
Sbjct: 430 ALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPAL 489
Query: 476 GVDINNEDIADNFEAFVWEPAMVRINALTAASEAACLIVSVDETIK 521
G+D ++ D + V E + + ++ A++ +I+ +D+ K
Sbjct: 490 GIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRK 535
>gi|58761484 chaperonin containing TCP1, subunit 3 isoform c [Homo
sapiens]
Length = 507
Score = 245 bits (625), Expect = 9e-65
Identities = 149/483 (30%), Positives = 249/483 (51%), Gaps = 18/483 (3%)
Query: 69 LDVVHPAAKTLVDIAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAFRTA 128
+ V HPAAK++++I+++QD EVGDGTTSV +LA E L + ++E+ +HP ++I A+R A
Sbjct: 32 IQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVISAYRKA 91
Query: 129 TQLAVNKIKEIAVTVKKADKVEQRKLLEKCAMTALSSKLISQQKAFFAKMVVDAVMMLD- 187
++ +K+I++ V +D ++ +++++K IS+ + + +DAV M+
Sbjct: 92 LDDMISTLKKISIPVDISDSDMMLNIIN----SSITTKAISRWSSLACNIALDAVKMVQF 147
Query: 188 ------DLLQLKMIGIKKVQGGALEDSQLVAGVAFKKTFSYAGFEMQPKKYHNPKIALLN 241
++ K ++K+ GG +EDS ++ GV K ++ K NP+I LL+
Sbjct: 148 EENGRKEIDIKKYARVEKIPGGIIEDSCVLRGVMINKDVTHPRMRRYIK---NPRIVLLD 204
Query: 242 VELELKAEKDNAEIRVHTVEDYQAIVDAEWNILYDKLEKIHHSGAKVVLSKLPIGDVATQ 301
LE K + +I + ED+ I+ E + E I VV+++ I D+A
Sbjct: 205 SSLEYKKGESQTDIEITREEDFTRILQMEEEYIQQLCEDIIQLKPDVVITEKGISDLAQH 264
Query: 302 YFADRDMFCAGRVPEEDLKRTMMACGGSIQTSVNALSADVLGR-CQVFEETQIGGERYNF 360
Y ++ RV + D R ACG I + L D +G + E +IG E + F
Sbjct: 265 YLMRANITAIRRVRKTDNNRIARACGARIVSRPEELREDDVGTGAGLLEIKKIGDEYFTF 324
Query: 361 FTGCPKAKTCTFILRGGAEQFMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYL 420
T C K CT +LRG +++ + E ER+L DA+ + R + + +V GGGA EM ++ L
Sbjct: 325 ITDCKDPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAVAHAL 384
Query: 421 RDYSRTIPGKQQLLIGAYAKALEIIPRQLCDNAGFDATNILNKLRARHAQGG--TWYGVD 478
+ S+ + G +Q A A+ALE+IPR L N G +L LRA+H Q TW GV+
Sbjct: 385 TEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQENCETW-GVN 443
Query: 479 INNEDIADNFEAFVWEPAMVRINALTAASEAACLIVSVDETIKNPRSTVDAPTAAGRGRG 538
+ D E +WEP V++ A E A L++ +D+ + + D + G
Sbjct: 444 GETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIVSGHKKKGDDQSRQGGAPD 503
Query: 539 RGR 541
G+
Sbjct: 504 AGQ 506
>gi|4502643 chaperonin containing TCP1, subunit 6A isoform a [Homo
sapiens]
Length = 531
Score = 236 bits (602), Expect = 4e-62
Identities = 148/518 (28%), Positives = 264/518 (50%), Gaps = 20/518 (3%)
Query: 22 LVSNISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISNDGATILKLLDVVHPAAKTLVD 81
L NISA + + + +RT LGP+G K++V G G ++ DG +L + + HP A +
Sbjct: 20 LAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLHEMQIQHPTASLIAK 79
Query: 82 IAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAFRTATQLAVNKIKEIAV 141
+A +QD GDGTTS L+ E LKQ Y+ EGLHP+II F A + A+ ++E+
Sbjct: 80 VATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIITEGFEAAKEKALQFLEEV-- 137
Query: 142 TVKKADKVEQRKLLEKCAMTALSSKLISQQKAFFAKMVVDAVMML---DDLLQLKMIGIK 198
K + R+ L A T+L +K+ ++ + VVD+++ + D+ + L MI I
Sbjct: 138 ---KVSREMDRETLIDVARTSLRTKVHAELADVLTEAVVDSILAIKKQDEPIDLFMIEIM 194
Query: 199 KVQGGALEDSQLVAGVAFKKTFSYAGFEMQPKKYHNPKIALLNVELELKAEKDNAEIRVH 258
+++ + D+ L+ G+ + + K+ + I NV LE + + N+
Sbjct: 195 EMKHKSETDTSLIRGLVLDHGARHPDMK---KRVEDAYILTCNVSLEYEKTEVNSGFFYK 251
Query: 259 TVEDYQAIVDAEWNILYDKLEKIHHSGAKV---------VLSKLPIGDVATQYFADRDMF 309
+ E+ + +V AE + D+++KI KV V+++ I + + +
Sbjct: 252 SAEEREKLVKAERKFIEDRVKKIIELKRKVCGDSDKGFVVINQKGIDPFSLDALSKEGIV 311
Query: 310 CAGRVPEEDLKRTMMACGGSIQTSVNALSADVLGRCQVFEETQIGGERYNFFTGCPKAKT 369
R +++R +ACGG S + LS D LG + E +G E++ F C ++
Sbjct: 312 ALRRAKRRNMERLTLACGGVALNSFDDLSPDCLGHAGLVYEYTLGEEKFTFIEKCNNPRS 371
Query: 370 CTFILRGGAEQFMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYLRDYSRTIPG 429
T +++G + + + + ++ D + V+ AI + VV G GA+E+ +++ L + ++ G
Sbjct: 372 VTLLIKGPNKHTLTQIKDAVRDGLRAVKNAIDDGCVVPGAGAVEVAMAEALIKHKPSVKG 431
Query: 430 KQQLLIGAYAKALEIIPRQLCDNAGFDATNILNKLRARHAQGGTWYGVDINNEDIADNFE 489
+ QL + A+A AL IIP+ L N+GFD L K++A H++ G GVD+N + E
Sbjct: 432 RAQLGVQAFADALLIIPKVLAQNSGFDLQETLVKIQAEHSESGQLVGVDLNTGEPMVAAE 491
Query: 490 AFVWEPAMVRINALTAASEAACLIVSVDETIKNPRSTV 527
VW+ V+ L + + A I+ VDE ++ S++
Sbjct: 492 VGVWDNYCVKKQLLHSCTVIATNILLVDEIMRAGMSSL 529
>gi|58331173 chaperonin containing TCP1, subunit 6B [Homo sapiens]
Length = 530
Score = 233 bits (593), Expect = 4e-61
Identities = 150/521 (28%), Positives = 264/521 (50%), Gaps = 26/521 (4%)
Query: 22 LVSNISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISNDGATILKLLDVVHPAAKTLVD 81
L NI A + + + +RT LGP+G K++V G G ++ DG +L + + HP A +
Sbjct: 20 LAVNICAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLDEMQIQHPTASLIAK 79
Query: 82 IAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAFRTATQLAVNKIKEIAV 141
+A +QD GDGTTS L+ E LKQ Y+ EGLHP+II F A A+ ++E+ V
Sbjct: 80 VATAQDDVTGDGTTSNVLIIGELLKQADLYISEGLHPRIIAEGFEAAKIKALEVLEEVKV 139
Query: 142 TVKKADKVEQRKLLEKCAMTALSSKLISQQKAFFAKMVVDAVMMLD------DLLQLKMI 195
T K +RK+L A T+L +K+ ++ ++VVD+V+ + DL ++++
Sbjct: 140 T-----KEMKRKILLDVARTSLQTKVHAELADVLTEVVVDSVLAVRRPGYPIDLFMVEIM 194
Query: 196 GIKKVQGGALEDSQLVAGVAFKKTFSYAGFEMQPKKYHNPKIALLNVELELKAEKDNAEI 255
+K G D++L+ G+ + + K+ + I + NV LE + + N+
Sbjct: 195 EMKHKLG---TDTKLIQGLVLDHGARHPDMK---KRVEDAFILICNVSLEYEKTEVNSGF 248
Query: 256 RVHTVEDYQAIVDAEWNILYDKLEKIHHSGAKV---------VLSKLPIGDVATQYFADR 306
T E+ + +V AE + D+++KI KV V+++ I + A
Sbjct: 249 FYKTAEEKEKLVKAERKFIEDRVQKIIDLKDKVCAQSNKGFVVINQKGIDPFSLDSLAKH 308
Query: 307 DMFCAGRVPEEDLKRTMMACGGSIQTSVNALSADVLGRCQVFEETQIGGERYNFFTGCPK 366
+ R +++R +ACGG S L+ D LG + E +G E++ F C
Sbjct: 309 GIVALRRAKRRNMERLSLACGGMAVNSFEDLTVDCLGHAGLVYEYTLGEEKFTFIEECVN 368
Query: 367 AKTCTFILRGGAEQFMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYLRDYSRT 426
+ T +++G + + + + ++ D + ++ AI++ +V G GAIE+ +++ L Y +
Sbjct: 369 PCSVTLLVKGPNKHTLTQVKDAIRDGLRAIKNAIEDGCMVPGAGAIEVAMAEALVTYKNS 428
Query: 427 IPGKQQLLIGAYAKALEIIPRQLCDNAGFDATNILNKLRARHAQGGTWYGVDINNEDIAD 486
I G+ +L + A+A AL IIP+ L NAG+D L K++A H + GVD+N +
Sbjct: 429 IKGRARLGVQAFADALLIIPKVLAQNAGYDPQETLVKVQAEHVESKQLVGVDLNTGEPMV 488
Query: 487 NFEAFVWEPAMVRINALTAASEAACLIVSVDETIKNPRSTV 527
+A VW+ V+ L + + A I+ VDE ++ S++
Sbjct: 489 AADAGVWDNYCVKKQLLHSCTVIATNILLVDEIMRAGMSSL 529
>gi|48762932 chaperonin containing TCP1, subunit 8 (theta) [Homo
sapiens]
Length = 548
Score = 206 bits (525), Expect = 3e-53
Identities = 143/523 (27%), Positives = 254/523 (48%), Gaps = 21/523 (4%)
Query: 8 LLKEGTDSSQGIPQLV-SNISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISNDGATIL 66
+LKEG G+ + V NI AC+ +A+ RT GP GM+K++++ K ++ND ATIL
Sbjct: 14 MLKEGAKHFSGLEEAVYRNIQACKELAQTTRTAYGPNGMNKMVINHLEKLFVTNDAATIL 73
Query: 67 KLLDVVHPAAKTLVDIAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAFR 126
+ L+V HPAAK +V + Q+ EVGDGT V + A L+ + + GL +I +
Sbjct: 74 RELEVQHPAAKMIVMASHMQEQEVGDGTNFVLVFAGALLELAEELLRIGLSVSEVIEGY- 132
Query: 127 TATQLAVNKIKEIAVTVKKADKVEQRKLLEKCAMTALSSKLISQQ---KAFFAKMVVDAV 183
++A K EI + R + E ++ L + ++S+Q + F AK++ A
Sbjct: 133 ---EIACRKAHEILPNLVCCSAKNLRDIDEVSSL--LRTSIMSKQYGNEVFLAKLIAQAC 187
Query: 184 MML---DDLLQLKMIGIKKVQGGALEDSQLVAGVAFKKTFSYAGFEMQPKKYHNPKIALL 240
+ + + I + K+ G + S ++ G+ FKK E + KIA+
Sbjct: 188 VSIFPDSGHFNVDNIRVCKILGSGISSSSVLHGMVFKKET-----EGDVTSVKDAKIAVY 242
Query: 241 NVELELKAEKDNAEIRVHTVEDYQAIVDAEWNILYDKLEKIHHSGAKVVLSKLPIGDVAT 300
+ + + + + T E+ E N++ +++ I +GA VV++ + D+A
Sbjct: 243 SCPFDGMITETKGTVLIKTAEELMNFSKGEENLMDAQVKAIADTGANVVVTGGKVADMAL 302
Query: 301 QYFADRDMFCAGRVPEEDLKRTMMACGGSIQTSVNALSADVLGRCQVFEETQIGGERYNF 360
Y ++ + DL+R G + + + +G C +++G +
Sbjct: 303 HYANKYNIMLVRLNSKWDLRRLCKTVGATALPRLTPPVLEEMGHCDSVYLSEVGDTQVVV 362
Query: 361 FTGCPK-AKTCTFILRGGAEQFMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKY 419
F + T +LRG + M++ ER++ D + + ++ +V GGGA E+EL+K
Sbjct: 363 FKHEKEDGAISTIVLRGSTDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAKQ 422
Query: 420 LRDYSRTIPGKQQLLIGAYAKALEIIPRQLCDNAGFDATNILNKLRARHAQGGTWYGVDI 479
+ Y T PG +Q I +A+A E IPR L +N+G A +++KL A H +G G+DI
Sbjct: 423 ITSYGETCPGLEQYAIKKFAEAFEAIPRALAENSGVKANEVISKLYAVHQEGNKNVGLDI 482
Query: 480 NNE--DIADNFEAFVWEPAMVRINALTAASEAACLIVSVDETI 520
E + D EA + + + + A+ A+ AA ++ VD+ I
Sbjct: 483 EAEVPAVKDMLEAGILDTYLGKYWAIKLATNAAVTVLRVDQII 525
>gi|57863259 T-complex protein 1 isoform b [Homo sapiens]
Length = 401
Score = 189 bits (481), Expect = 4e-48
Identities = 124/388 (31%), Positives = 204/388 (52%), Gaps = 25/388 (6%)
Query: 163 LSSKLISQQKAFFAKMVVDAVMML-------DDLLQLKMIGIKKVQGGALEDSQLVAGVA 215
+SSK+I FFA MVVDAV+ + + + I K G + +S L++G A
Sbjct: 1 MSSKIIGINGDFFANMVVDAVLAIKYTDIRGQPRYPVNSVNILKAHGRSQMESMLISGYA 60
Query: 216 FKKTFSYAGFEMQPKKYHNPKIALLNVELELKAEKDNAEIRVHTVEDYQAIVDAEWNILY 275
G + PK+ N KIA L+ L+ K ++ + E I E +I
Sbjct: 61 LN---CVVGSQGMPKRIVNAKIACLDFSLQKTKMKLGVQVVITDPEKLDQIRQRESDITK 117
Query: 276 DKLEKIHHSGAKVVLSKLPIGDVATQYFADRDMFCAGRVPEEDLKRTMMACGGSIQTSVN 335
++++KI +GA V+L+ I D+ +YF + RV + DLKR A G +I +++
Sbjct: 118 ERIQKILATGANVILTTGGIDDMCLKYFVEAGAMAVRRVLKRDLKRIAKASGATILSTLA 177
Query: 336 ALSAD------VLGRCQVFEETQIGGERYNFFTGCPKAKTCTFILRGGAEQFMEETERSL 389
L + +LG+ + + +I + + + ILRG + +E ERSL
Sbjct: 178 NLEGEETFEAAMLGQAEEVVQERICDDELILIKNTKARTSASIILRGANDFMCDEMERSL 237
Query: 390 HDAIMIVRRAIKNDSVVAGGGAIEMELSKYLRDYSRTIPGKQQLLIGAYAKALEIIPRQL 449
HDA+ +V+R +++ SVV GGGA+E LS YL +Y+ ++ ++QL I +A++L +IP L
Sbjct: 238 HDALCVVKRVLESKSVVPGGGAVEAALSIYLENYATSMGSREQLAIAEFARSLLVIPNTL 297
Query: 450 CDNAGFDATNILNKLRARHAQGGT--------WYGVDINNEDIADNFEAFVWEPAMVRIN 501
NA D+T+++ KLRA H + W G+D++N DN +A V+EP +V++
Sbjct: 298 AVNAAQDSTDLVAKLRAFHNEAQVNPERKNLKWIGLDLSNGKPRDNKQAGVFEPTIVKVK 357
Query: 502 ALTAASEAACLIVSVDETIK-NPRSTVD 528
+L A+EAA I+ +D+ IK +P S D
Sbjct: 358 SLKFATEAAITILRIDDLIKLHPESKDD 385
>gi|58331171 chaperonin containing TCP1, subunit 6A isoform b [Homo
sapiens]
Length = 486
Score = 179 bits (453), Expect = 8e-45
Identities = 130/518 (25%), Positives = 239/518 (46%), Gaps = 65/518 (12%)
Query: 22 LVSNISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISNDGATILKLLDVVHPAAKTLVD 81
L NISA + + + +RT LGP+G K++V G G ++ DG +L
Sbjct: 20 LAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLH-------------- 65
Query: 82 IAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAFRTATQLAVNKIKEIAV 141
E GLHP+II F A + A+ ++E+
Sbjct: 66 -------------------------------EMGLHPRIITEGFEAAKEKALQFLEEV-- 92
Query: 142 TVKKADKVEQRKLLEKCAMTALSSKLISQQKAFFAKMVVDAVMML---DDLLQLKMIGIK 198
K + R+ L A T+L +K+ ++ + VVD+++ + D+ + L MI I
Sbjct: 93 ---KVSREMDRETLIDVARTSLRTKVHAELADVLTEAVVDSILAIKKQDEPIDLFMIEIM 149
Query: 199 KVQGGALEDSQLVAGVAFKKTFSYAGFEMQPKKYHNPKIALLNVELELKAEKDNAEIRVH 258
+++ + D+ L+ G+ + + K+ + I NV LE + + N+
Sbjct: 150 EMKHKSETDTSLIRGLVLDHGARHPDMK---KRVEDAYILTCNVSLEYEKTEVNSGFFYK 206
Query: 259 TVEDYQAIVDAEWNILYDKLEKIHHSGAKV---------VLSKLPIGDVATQYFADRDMF 309
+ E+ + +V AE + D+++KI KV V+++ I + + +
Sbjct: 207 SAEEREKLVKAERKFIEDRVKKIIELKRKVCGDSDKGFVVINQKGIDPFSLDALSKEGIV 266
Query: 310 CAGRVPEEDLKRTMMACGGSIQTSVNALSADVLGRCQVFEETQIGGERYNFFTGCPKAKT 369
R +++R +ACGG S + LS D LG + E +G E++ F C ++
Sbjct: 267 ALRRAKRRNMERLTLACGGVALNSFDDLSPDCLGHAGLVYEYTLGEEKFTFIEKCNNPRS 326
Query: 370 CTFILRGGAEQFMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYLRDYSRTIPG 429
T +++G + + + + ++ D + V+ AI + VV G GA+E+ +++ L + ++ G
Sbjct: 327 VTLLIKGPNKHTLTQIKDAVRDGLRAVKNAIDDGCVVPGAGAVEVAMAEALIKHKPSVKG 386
Query: 430 KQQLLIGAYAKALEIIPRQLCDNAGFDATNILNKLRARHAQGGTWYGVDINNEDIADNFE 489
+ QL + A+A AL IIP+ L N+GFD L K++A H++ G GVD+N + E
Sbjct: 387 RAQLGVQAFADALLIIPKVLAQNSGFDLQETLVKIQAEHSESGQLVGVDLNTGEPMVAAE 446
Query: 490 AFVWEPAMVRINALTAASEAACLIVSVDETIKNPRSTV 527
VW+ V+ L + + A I+ VDE ++ S++
Sbjct: 447 VGVWDNYCVKKQLLHSCTVIATNILLVDEIMRAGMSSL 484
>gi|7657253 T-complex protein 1 [Homo sapiens]
Length = 557
Score = 129 bits (323), Expect = 9e-30
Identities = 117/512 (22%), Positives = 215/512 (41%), Gaps = 22/512 (4%)
Query: 20 PQLVSNISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISNDGATILKLLDVVHPAAKTL 79
P L+S+++A Q +A +R GP G K +V +G+ + IL+ L++ HPAA L
Sbjct: 31 PHLLSSLAAVQTLASVIRPCYGPHGRQKFLVTMKGETVCTGCATAILRALELEHPAAWLL 90
Query: 80 VDIAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAFRTATQLAVNKIKEI 139
+ ++Q GDGT V LL L+Q + ++ GL + A+ TAT + + +
Sbjct: 91 REAGQTQAENSGDGTAFVVLLTEALLEQAEQLLKAGLPRPQLREAYATATAEVLATLPSL 150
Query: 140 AVTVKKADKVEQRKLLEKCAMTALSSKLISQQKAFFAKMVVD---AVMMLDDLLQLKMIG 196
A ++ +E A+ ++ + K+V A+ LD + + +G
Sbjct: 151 A--IQSLGPLED----PSWALHSVMNTHTLSPMDHLTKLVAHACWAIKELDGSFKPERVG 204
Query: 197 IKKVQGGALEDSQLVAGVAFKKTFSYAGFEMQPKKYHNPKIALLNVELELKAEKDNAEIR 256
+ + GG LEDS L+ G+A ++AL A R
Sbjct: 205 VCALPGGTLEDSCLLPGLAISGKLC----GQMATVLSGARVALFACPFGPAHPNAPATAR 260
Query: 257 VHTVEDYQAIVDAEWNILYDKLEKIHHSGAKVVLSKLPIGDVATQYFADRDMFCAGRVPE 316
+ + D +L ++ ++ +G V + +G+V + D + +
Sbjct: 261 LSSPADLAQFSKGSDQLLEKQVGQLAAAGINVA---VVLGEVDEETLTLADKYGIVVIQA 317
Query: 317 EDLKRTMMACGGSIQTSV--NALSADVLGRCQVFEETQIG-GERYNFFTGCPKAKTCTFI 373
++ + T + L G+CQ ++G G F C T +
Sbjct: 318 RSWME-IIYLSEVLDTPLLPRLLPPQRPGKCQRVYRQELGDGLAVVFEWECTGTPALTVV 376
Query: 374 LRGGAEQFMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYLRDYSRTIPGKQQL 433
LRG Q + E++++ I + ++ ++ G GA EM L+K L D + G
Sbjct: 377 LRGATTQGLRSAEQAVYHGIDAYFQLCQDPRLIPGAGATEMALAKMLSDKGSRLEGPSGP 436
Query: 434 LIGAYAKALEIIPRQLCDNAGFDATNILNKLRARHAQGGTWYGVDINNEDIADNFEAFVW 493
A+A AL+ +P+ L +NAG ++++ ++ H G GV E I + + VW
Sbjct: 437 AFLAFAWALKYLPKTLAENAGLAVSDVMAEMSGVHQGGNLLMGV--GTEGIINVAQEGVW 494
Query: 494 EPAMVRINALTAASEAACLIVSVDETIKNPRS 525
+ +V+ A +E +V+VDE + +S
Sbjct: 495 DTLIVKAQGFRAVAEVVLQLVTVDEIVVAKKS 526
>gi|41399285 chaperonin [Homo sapiens]
Length = 573
Score = 76.6 bits (187), Expect = 5e-14
Identities = 120/546 (21%), Positives = 214/546 (39%), Gaps = 50/546 (9%)
Query: 26 ISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISNDGATILKLLDVVHP----AAKTLVD 81
+ ++A+AV T+GP+G +I G ++ DG T+ K +D+ AK + D
Sbjct: 41 LQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQD 100
Query: 82 IAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAFRTATQLAVNKIKEIAV 141
+A + + E GDGTT+ T+LA K+ + +G +P I R A + ++K+ +
Sbjct: 101 VANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSK 160
Query: 142 TVKKADKVEQRKLLEKCAMTALSSKLISQQKAFFAKMVV---DAVMMLDDLLQLKMIGIK 198
V +++ Q + + + + K K V+ D + D +L++I
Sbjct: 161 PVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLND---ELEIIEGM 217
Query: 199 KVQGGALEDSQLVAGVAFKKTFSYAGFEMQPKKYHNPKIALLNVELELKAEKDNAEIRVH 258
K G + + K F A + KK ++ ++ L+ + + V
Sbjct: 218 KFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKIS----SIQSIVPALEIANAHRKPLVI 273
Query: 259 TVEDYQAIVDAEWNILYDKLEKIHHSGAKVVLSKLP-IGDVATQYFADRDMFCAGRV-PE 316
ED +A ++ ++L+ G +VV K P GD D + G V E
Sbjct: 274 IAEDVDG--EALSTLVLNRLK----VGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGE 327
Query: 317 EDL--------KRTMMACGGSIQTSVNAL-------SADVLGRCQ-VFEETQIGGERY-- 358
E L + G I T +A+ A + R Q + E+ + Y
Sbjct: 328 EGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEK 387
Query: 359 -NFFTGCPKAKTCTFILRGGAEQFMEETERS--LHDAIMIVRRAIKNDSVVAGGGAIEME 415
K +L+ G +E E+ + DA+ R A++ + +V GGG +
Sbjct: 388 EKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVE-EGIVLGGGCALLR 446
Query: 416 LSKYLRDYSRTIPGKQQLLIGAYAKALEIIPRQLCDNAGFDATNILNKLRARHAQGGTWY 475
L D Q++ I + L+I + NAG + + I+ K+ Q +
Sbjct: 447 CIPAL-DSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKI----MQSSSEV 501
Query: 476 GVDINNEDIADNFEAFVWEPAMVRINALTAASEAACLIVSVDETIKN-PRSTVDAPTAAG 534
G D D + E + +P V AL A+ A L+ + + + P+ D A
Sbjct: 502 GYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAM 561
Query: 535 RGRGRG 540
G G G
Sbjct: 562 GGMGGG 567
>gi|31542947 chaperonin [Homo sapiens]
Length = 573
Score = 76.6 bits (187), Expect = 5e-14
Identities = 120/546 (21%), Positives = 214/546 (39%), Gaps = 50/546 (9%)
Query: 26 ISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISNDGATILKLLDVVHP----AAKTLVD 81
+ ++A+AV T+GP+G +I G ++ DG T+ K +D+ AK + D
Sbjct: 41 LQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQD 100
Query: 82 IAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAFRTATQLAVNKIKEIAV 141
+A + + E GDGTT+ T+LA K+ + +G +P I R A + ++K+ +
Sbjct: 101 VANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSK 160
Query: 142 TVKKADKVEQRKLLEKCAMTALSSKLISQQKAFFAKMVV---DAVMMLDDLLQLKMIGIK 198
V +++ Q + + + + K K V+ D + D +L++I
Sbjct: 161 PVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLND---ELEIIEGM 217
Query: 199 KVQGGALEDSQLVAGVAFKKTFSYAGFEMQPKKYHNPKIALLNVELELKAEKDNAEIRVH 258
K G + + K F A + KK ++ ++ L+ + + V
Sbjct: 218 KFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKIS----SIQSIVPALEIANAHRKPLVI 273
Query: 259 TVEDYQAIVDAEWNILYDKLEKIHHSGAKVVLSKLP-IGDVATQYFADRDMFCAGRV-PE 316
ED +A ++ ++L+ G +VV K P GD D + G V E
Sbjct: 274 IAEDVDG--EALSTLVLNRLK----VGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGE 327
Query: 317 EDL--------KRTMMACGGSIQTSVNAL-------SADVLGRCQ-VFEETQIGGERY-- 358
E L + G I T +A+ A + R Q + E+ + Y
Sbjct: 328 EGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEK 387
Query: 359 -NFFTGCPKAKTCTFILRGGAEQFMEETERS--LHDAIMIVRRAIKNDSVVAGGGAIEME 415
K +L+ G +E E+ + DA+ R A++ + +V GGG +
Sbjct: 388 EKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVE-EGIVLGGGCALLR 446
Query: 416 LSKYLRDYSRTIPGKQQLLIGAYAKALEIIPRQLCDNAGFDATNILNKLRARHAQGGTWY 475
L D Q++ I + L+I + NAG + + I+ K+ Q +
Sbjct: 447 CIPAL-DSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKI----MQSSSEV 501
Query: 476 GVDINNEDIADNFEAFVWEPAMVRINALTAASEAACLIVSVDETIKN-PRSTVDAPTAAG 534
G D D + E + +P V AL A+ A L+ + + + P+ D A
Sbjct: 502 GYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAM 561
Query: 535 RGRGRG 540
G G G
Sbjct: 562 GGMGGG 567
>gi|121583483 phosphatidylinositol-3-phosphate 5-kinase type III
isoform 2 [Homo sapiens]
Length = 2098
Score = 51.6 bits (122), Expect = 2e-06
Identities = 50/199 (25%), Positives = 83/199 (41%), Gaps = 15/199 (7%)
Query: 187 DDLLQLKMIGIKKVQGGALEDSQLVAGVAFKKTFSYAGFEMQPKKYHNPKIALLNVELEL 246
DD+ + + IKK+ GG DS +V G K ++ K NPKI LL +E
Sbjct: 657 DDMDIRQFVHIKKIPGGKKFDSVVVNGFVCTKNIAHKKMSSCIK---NPKILLLKCSIEY 713
Query: 247 KAEKDNAEIRVHTVEDYQAIVDAEWNILYDKLEKIHHSGAKVVLSKLPIGDVATQYFADR 306
++ + IV E L + +++I +VL + + +A +
Sbjct: 714 LYREETKFTCI------DPIVLQEREFLKNYVQRIVDVRPTLVLVEKTVSRIAQDMLLEH 767
Query: 307 DMFCAGRVPEEDLKR-TMMACGGSIQTSVNALSADVLGRC-----QVFEETQIGGERYNF 360
+ V + L+R + M G + + L+ LG C Q+F+ + F
Sbjct: 768 GITLVINVKSQVLERISRMTQGDLVMSMDQLLTKPHLGTCHKFYMQIFQLPNEQTKTLMF 827
Query: 361 FTGCPKAKTCTFILRGGAE 379
F GCP+ CT LRGG++
Sbjct: 828 FEGCPQHLGCTIKLRGGSD 846
>gi|100816407 Bardet-Biedl syndrome 10 [Homo sapiens]
Length = 723
Score = 46.6 bits (109), Expect = 6e-05
Identities = 81/427 (18%), Positives = 155/427 (36%), Gaps = 64/427 (14%)
Query: 26 ISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISNDGATILKLLDVVHPAAKTLVDIAKS 85
+ +V+ V +GP G L G+ +S +G +L+ L + HP A+ +VD S
Sbjct: 15 LQVAEVLEAIVSCCVGPEGRQVLCTKPTGEVLLSRNGGRLLEALHLEHPIARMIVDCVSS 74
Query: 86 QDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHP-------------------QIIIRAFR 126
+ GDG + + L+ + + P + I +A
Sbjct: 75 HLKKTGDGAKTFIIFLCHLLRGLHAITDREKDPLMCENIQTHGRHWKNCSRWKFISQALL 134
Query: 127 TATQLAVNKIKE-------IAVTVKKADKVEQRKLLEK------CAMTALSS-KLISQQ- 171
T ++ I + +++ ++ R LE C ++ K ISQ
Sbjct: 135 TFQTQILDGIMDQYLSRHFLSIFSSAKERTLCRSSLELLLEAYFCGRVGRNNHKFISQLM 194
Query: 172 -----KAFFAKMVVDAVMMLDDLLQLKMIGIKKVQGGALEDSQLVAGVAFKKTFSY---A 223
K K + ++DD +G V G + DS+++AG+ +K FS A
Sbjct: 195 CDYFFKCMTCKSGIGVFELVDDHFVELNVG---VTGLPVSDSRIIAGLVLQKDFSVYRPA 251
Query: 224 GFEMQ---PKKYHNPKIALLNVELELKAEKDNAEIRVHTVEDYQAIVDAEWNILYDKLEK 280
+M+ + P + E L +E + +E +AI ++
Sbjct: 252 DGDMRMVIVTETIQPLFSTSGSEFILNSEAQFQTSQFWIMEKTKAI-----------MKH 300
Query: 281 IHHSGAKVVLSKLPIGDVATQYFADRDMFCAGRVPEEDLKRTMMACGGSIQTSVNALSAD 340
+H K+++S + D+ + Y + + E++ G S A S
Sbjct: 301 LHSQNVKLLISSVKQPDLVSYYAGVNGISVVECLSSEEVSLIRRIIGLSPFVPPQAFSQC 360
Query: 341 VLGRCQVFEETQIGGERYNFFTGCPKAKTCTFI-----LRGGAEQFMEETERSLHDAIMI 395
+ + + + R + TC FI L G +E+ E +LH A+ +
Sbjct: 361 EIPNTALVKFCKPLILRSKRYVHLGLISTCAFIPHSIVLCGPVHGLIEQHEDALHGALKM 420
Query: 396 VRRAIKN 402
+R+ K+
Sbjct: 421 LRQLFKD 427
>gi|9055272 McKusick-Kaufman syndrome protein [Homo sapiens]
Length = 570
Score = 40.0 bits (92), Expect = 0.005
Identities = 84/449 (18%), Positives = 170/449 (37%), Gaps = 35/449 (7%)
Query: 31 VIAEAVRTTLGPRGMDKLIVDGRGK--ATISNDGATILKLLDVVHPAAKTLVDIAKSQDA 88
V+ V + GP G K + +G G T S A + LL V HP K L ++ +
Sbjct: 28 VLKRIVTSCYGPSGRLKQLHNGFGGYVCTTSQSSALLSHLL-VTHPILKILTASIQNHVS 86
Query: 89 EVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAFRTATQLAVNKIKEIAVTVKKADK 148
D +L ++ V+ GL P +IR + L ++ +K +
Sbjct: 87 SFSDCGLFTAILCCNLIENVQRL---GLTPTTVIRLNKHLLSLCISYLKSETCGCRIPVD 143
Query: 149 VEQRKLLEKCAMTALSSK----LISQQKAFFAKMVVDAVMML-----DDLLQLKMIGIKK 199
++L + L+SK L ++ + +++ A ++ + + L I
Sbjct: 144 FSSTQILLCLVRSILTSKPACMLTRKETEHVSALILRAFLLTIPENAEGHIILGKSLIVP 203
Query: 200 VQGGALEDSQLVAGVAFKKTFSYAGFEMQPKKYHNPKIALLNVEL--ELKAEKDNAEIRV 257
++G + DS ++ G+ + + + KK K+AL L + + +
Sbjct: 204 LKGQRVIDSTVLPGILIEMSEVQLMRLLPIKKSTALKVALFCTTLSGDTSDTGEGTVVVS 263
Query: 258 HTVEDYQAIVDAEWNILYDKLEKIHHSGAKVVLSKLPIGDVATQYFADRDMFCAGRVPEE 317
+ V A++D N+ ++ +VL + I Q+ + R+
Sbjct: 264 YGVSLENAVLDQLLNLG----RQLISDHVDLVLCQKVIHPSLKQFLNMHRIIAIDRIGVT 319
Query: 318 DLKRTMMACGGSIQTSVNALSADVLGRCQVFEETQIGGERYNFFTGCPKAKT-CTFILRG 376
++ G S+ ++ + G + + G + +FF P T C+ +L
Sbjct: 320 LMEPLTKMTGTQPIGSLGSICPNSYGSVKDVCTAKFGSK--HFFHLIPNEATICSLLLCN 377
Query: 377 GAEQFMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYLRDYSRTIP-------- 428
+ +E + + A+ +++ +K + GGG E L+ Y+R + P
Sbjct: 378 RNDTAWDELKLTCQTALHVLQLTLKEPWALLGGGCTETHLAAYIRHKTHNDPESILKDDE 437
Query: 429 ---GKQQLLIGAYAKALEIIPRQLCDNAG 454
+ QL+ A+ ALE + L + G
Sbjct: 438 CTQTELQLIAEAFCSALESVVGSLEHDGG 466
>gi|25914754 McKusick-Kaufman syndrome protein [Homo sapiens]
Length = 570
Score = 40.0 bits (92), Expect = 0.005
Identities = 84/449 (18%), Positives = 170/449 (37%), Gaps = 35/449 (7%)
Query: 31 VIAEAVRTTLGPRGMDKLIVDGRGK--ATISNDGATILKLLDVVHPAAKTLVDIAKSQDA 88
V+ V + GP G K + +G G T S A + LL V HP K L ++ +
Sbjct: 28 VLKRIVTSCYGPSGRLKQLHNGFGGYVCTTSQSSALLSHLL-VTHPILKILTASIQNHVS 86
Query: 89 EVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAFRTATQLAVNKIKEIAVTVKKADK 148
D +L ++ V+ GL P +IR + L ++ +K +
Sbjct: 87 SFSDCGLFTAILCCNLIENVQRL---GLTPTTVIRLNKHLLSLCISYLKSETCGCRIPVD 143
Query: 149 VEQRKLLEKCAMTALSSK----LISQQKAFFAKMVVDAVMML-----DDLLQLKMIGIKK 199
++L + L+SK L ++ + +++ A ++ + + L I
Sbjct: 144 FSSTQILLCLVRSILTSKPACMLTRKETEHVSALILRAFLLTIPENAEGHIILGKSLIVP 203
Query: 200 VQGGALEDSQLVAGVAFKKTFSYAGFEMQPKKYHNPKIALLNVEL--ELKAEKDNAEIRV 257
++G + DS ++ G+ + + + KK K+AL L + + +
Sbjct: 204 LKGQRVIDSTVLPGILIEMSEVQLMRLLPIKKSTALKVALFCTTLSGDTSDTGEGTVVVS 263
Query: 258 HTVEDYQAIVDAEWNILYDKLEKIHHSGAKVVLSKLPIGDVATQYFADRDMFCAGRVPEE 317
+ V A++D N+ ++ +VL + I Q+ + R+
Sbjct: 264 YGVSLENAVLDQLLNLG----RQLISDHVDLVLCQKVIHPSLKQFLNMHRIIAIDRIGVT 319
Query: 318 DLKRTMMACGGSIQTSVNALSADVLGRCQVFEETQIGGERYNFFTGCPKAKT-CTFILRG 376
++ G S+ ++ + G + + G + +FF P T C+ +L
Sbjct: 320 LMEPLTKMTGTQPIGSLGSICPNSYGSVKDVCTAKFGSK--HFFHLIPNEATICSLLLCN 377
Query: 377 GAEQFMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYLRDYSRTIP-------- 428
+ +E + + A+ +++ +K + GGG E L+ Y+R + P
Sbjct: 378 RNDTAWDELKLTCQTALHVLQLTLKEPWALLGGGCTETHLAAYIRHKTHNDPESILKDDE 437
Query: 429 ---GKQQLLIGAYAKALEIIPRQLCDNAG 454
+ QL+ A+ ALE + L + G
Sbjct: 438 CTQTELQLIAEAFCSALESVVGSLEHDGG 466
>gi|115527097 CDC42-binding protein kinase beta [Homo sapiens]
Length = 1711
Score = 32.0 bits (71), Expect = 1.5
Identities = 45/202 (22%), Positives = 76/202 (37%), Gaps = 21/202 (10%)
Query: 84 KSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAFRTATQ---LAVNKIKEIA 140
KSQ E+ D L EF + + E Q + R R + +A K+ +
Sbjct: 557 KSQAKELKDAHQQRKLALQEFSELNERMAELRAQKQKVSRQLRDKEEEMEVATQKVDAMR 616
Query: 141 VTVKKADKV--EQRKLLEKCAMTALSSKLISQQKAFFAKMVVDAVMMLDDLLQLKMIGIK 198
+++A+K+ E L+ A + + + F K M +L LK+
Sbjct: 617 QEMRRAEKLRKELEAQLDDAVAEASKERKLREHSENFCKQ------MESELEALKVKQGG 670
Query: 199 KVQGGALEDSQLVAGVAFKKTFSYAGFEMQPKKYHNPKIALLNVELELKAEKDNAEIRVH 258
+ G LE Q ++ + + +E + L+ E E N + VH
Sbjct: 671 RGAGATLEHQQEISKIKSELEKKVLFYEEE----------LVRREASHVLEVKNVKKEVH 720
Query: 259 TVEDYQAIVDAEWNILYDKLEK 280
E +Q + E +L DKLEK
Sbjct: 721 DSESHQLALQKEILMLKDKLEK 742
>gi|40217788 Bardet-Biedl syndrome 12 [Homo sapiens]
Length = 710
Score = 31.6 bits (70), Expect = 1.9
Identities = 44/200 (22%), Positives = 79/200 (39%), Gaps = 19/200 (9%)
Query: 33 AEAVRTTLGPRGMDKLIVDGR-GKATISNDGATILKLLDVVHPAAKTLVDIAKSQDAEVG 91
AE RT LGP K I+D ++ + + +L+ LD+ + L + ++Q+
Sbjct: 23 AETGRTFLGPLKSSKFIIDEECHESVLISSTVRLLESLDLTSAVGQLLNEAVQAQNNTYR 82
Query: 92 DGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAFRTATQLAVNKIKEIAVTVKKA-DKVE 150
G +++ L + V+ + G+ II+ ++ + V V D ++
Sbjct: 83 TGISTLLFLVGAWSSAVEECLHLGVPISIIVSVMSEGLNFCSEEVVSLHVPVHNIFDCMD 142
Query: 151 QRKLLEKCAMTALSSKLISQQKAFFAKMVVDAVMMLDDLLQLKMIGIKKVQGGALEDSQL 210
S+K SQ + F + + D L ++ G+K V L S L
Sbjct: 143 -------------STKTFSQLETFSVSLCPFLQVPSDTDLIEELHGLKDVASQTLTISNL 189
Query: 211 VAGVAFKKTFSYAGFEMQPK 230
+G K SY F+ Q K
Sbjct: 190 -SGRPLK---SYELFKPQTK 205
>gi|24234690 meiotic recombination 11 homolog A isoform 2 [Homo
sapiens]
Length = 680
Score = 30.8 bits (68), Expect = 3.3
Identities = 19/55 (34%), Positives = 26/55 (47%), Gaps = 9/55 (16%)
Query: 496 AMVRINALTAASEAACLIVSVDETIK---------NPRSTVDAPTAAGRGRGRGR 541
AM R AL + SE + S D+ + + ++ A T GRGRGRGR
Sbjct: 522 AMTRARALRSQSEESASAFSADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGR 576
>gi|5031923 meiotic recombination 11 homolog A isoform 1 [Homo
sapiens]
Length = 708
Score = 30.8 bits (68), Expect = 3.3
Identities = 19/55 (34%), Positives = 26/55 (47%), Gaps = 9/55 (16%)
Query: 496 AMVRINALTAASEAACLIVSVDETIK---------NPRSTVDAPTAAGRGRGRGR 541
AM R AL + SE + S D+ + + ++ A T GRGRGRGR
Sbjct: 522 AMTRARALRSQSEESASAFSADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGR 576
>gi|226437568 apoptosis-inducing factor, mitochondrion-associated, 3
isoform 3 [Homo sapiens]
Length = 604
Score = 30.0 bits (66), Expect = 5.6
Identities = 29/110 (26%), Positives = 49/110 (44%), Gaps = 7/110 (6%)
Query: 320 KRTMMACGGSIQTSVNALSADVLGRCQVFEET-QIGGERYNFFTGC-PKAKTCTFILRGG 377
K A G + T ++ DV + VF++ ++ + G PK +C G
Sbjct: 260 KEFFRAYGIEVLTEAQVVTVDVRTKKVVFKDGFKLEYSKLLLAPGSSPKTLSCK-----G 314
Query: 378 AEQFMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYLRDYSRTI 427
E T R+ DA +VR A + VV G G + ME++ YL + + ++
Sbjct: 315 KEVENVFTIRTPEDANRVVRLARGRNVVVVGAGFLGMEVAAYLTEKAHSV 364
>gi|65787454 apoptosis-inducing factor, mitochondrion-associated, 3
isoform 2 [Homo sapiens]
Length = 598
Score = 30.0 bits (66), Expect = 5.6
Identities = 29/110 (26%), Positives = 49/110 (44%), Gaps = 7/110 (6%)
Query: 320 KRTMMACGGSIQTSVNALSADVLGRCQVFEET-QIGGERYNFFTGC-PKAKTCTFILRGG 377
K A G + T ++ DV + VF++ ++ + G PK +C G
Sbjct: 254 KEFFRAYGIEVLTEAQVVTVDVRTKKVVFKDGFKLEYSKLLLAPGSSPKTLSCK-----G 308
Query: 378 AEQFMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYLRDYSRTI 427
E T R+ DA +VR A + VV G G + ME++ YL + + ++
Sbjct: 309 KEVENVFTIRTPEDANRVVRLARGRNVVVVGAGFLGMEVAAYLTEKAHSV 358
>gi|21389617 apoptosis-inducing factor, mitochondrion-associated, 3
isoform 1 [Homo sapiens]
Length = 605
Score = 30.0 bits (66), Expect = 5.6
Identities = 29/110 (26%), Positives = 49/110 (44%), Gaps = 7/110 (6%)
Query: 320 KRTMMACGGSIQTSVNALSADVLGRCQVFEET-QIGGERYNFFTGC-PKAKTCTFILRGG 377
K A G + T ++ DV + VF++ ++ + G PK +C G
Sbjct: 254 KEFFRAYGIEVLTEAQVVTVDVRTKKVVFKDGFKLEYSKLLLAPGSSPKTLSCK-----G 308
Query: 378 AEQFMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYLRDYSRTI 427
E T R+ DA +VR A + VV G G + ME++ YL + + ++
Sbjct: 309 KEVENVFTIRTPEDANRVVRLARGRNVVVVGAGFLGMEVAAYLTEKAHSV 358
>gi|51558724 ADAM metallopeptidase with thrombospondin type 1 motif,
12 preproprotein [Homo sapiens]
Length = 1594
Score = 30.0 bits (66), Expect = 5.6
Identities = 40/166 (24%), Positives = 69/166 (41%), Gaps = 33/166 (19%)
Query: 104 FLKQVK--PYVEEGLHPQIIIRAFRTATQLAVNKIKEIAVTVKKADKVEQRKLL--EKCA 159
F++ VK P VE G HP I+ R + V + KE +K + + Q++ L EK
Sbjct: 175 FIEPVKKHPLVEGGYHPHIVYR------RQKVPETKEPTCGLKDSVNISQKQELWREKWE 228
Query: 160 MTALSSKLISQQKAFFAKMVVDAVMMLDDLLQLKMIGIKKVQGGALEDSQLVAGVAFKKT 219
L S+ +S++ + V +++ D ++ G + V+ L +V G+
Sbjct: 229 RHNLPSRSLSRRSISKERWV--ETLVVADTKMIEYHGSENVESYILTIMNMVTGL----- 281
Query: 220 FSYAGFEMQPKKYHNPKIA----LLNVELELKAEKDNAEIRVHTVE 261
+HNP I ++ V L L E++ VH E
Sbjct: 282 ------------FHNPSIGNAIHIVVVRLILLEEEEQGLKIVHHAE 315
>gi|115527120 nebulin [Homo sapiens]
Length = 6669
Score = 29.6 bits (65), Expect = 7.4
Identities = 17/69 (24%), Positives = 30/69 (43%), Gaps = 3/69 (4%)
Query: 218 KTFSYAGFEMQPKKYHNPKIALLNVELELKAEKDNAEIRVHTVEDYQAIV---DAEWNIL 274
K + E PK H+ ++A + + E K +N + HT D ++ DA+ NI
Sbjct: 2074 KMVGFRSLEDDPKLVHSMQVAKMQSDREYKKNYENTKTSYHTPADMLSVTAAKDAQANIT 2133
Query: 275 YDKLEKIHH 283
+ + H
Sbjct: 2134 NTNYKHLIH 2142
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.379
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,876,648
Number of Sequences: 37866
Number of extensions: 704912
Number of successful extensions: 1896
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 1825
Number of HSP's gapped (non-prelim): 45
length of query: 543
length of database: 18,247,518
effective HSP length: 107
effective length of query: 436
effective length of database: 14,195,856
effective search space: 6189393216
effective search space used: 6189393216
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.