Search of human proteins with 50363228

Search of human proteins with 50363228

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|50363228 RAB11 family interacting protein 1 isoform 1 [Homo
sapiens]
         (649 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|50363228 RAB11 family interacting protein 1 isoform 1 [Homo s...  1268   0.0  
gi|50659104 RAB11 family interacting protein 1 isoform 3 [Homo s...  1060   0.0  
gi|24308075 RAB11 family interacting protein 5 (class I) [Homo s...   311   1e-84
gi|7662394 RAB11 family interacting protein 2 (class I) [Homo sa...   253   4e-67
gi|50363230 RAB11 family interacting protein 1 isoform 2 [Homo s...   221   2e-57
gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo...    53   8e-07
gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Hom...    53   8e-07
gi|122937247 unc-13 homolog A [Homo sapiens]                           49   1e-05
gi|122937514 unc-13 homolog C [Homo sapiens]                           49   1e-05
gi|110611226 UNC13 (C. elegans)-like [Homo sapiens]                    48   3e-05
gi|92859638 synaptotagmin V [Homo sapiens]                             46   1e-04
gi|209447073 synaptotagmin I [Homo sapiens]                            45   2e-04
gi|5032139 synaptotagmin I [Homo sapiens]                              45   2e-04
gi|209447070 synaptotagmin I [Homo sapiens]                            45   2e-04
gi|4759026 RAS protein activator like 1 [Homo sapiens]                 45   3e-04
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa...    44   4e-04
gi|194294523 intersectin 2 isoform 3 [Homo sapiens]                    44   4e-04
gi|194294521 intersectin 2 isoform 1 [Homo sapiens]                    44   4e-04
gi|211059429 synaptotagmin II [Homo sapiens]                           44   5e-04
gi|31543670 synaptotagmin II [Homo sapiens]                            44   5e-04
gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2...    44   6e-04
gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1...    44   6e-04
gi|104526627 triadin [Homo sapiens]                                    43   8e-04
gi|56550039 myeloid/lymphoid or mixed-lineage leukemia protein [...    42   0.002
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]    42   0.002
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]    42   0.002
gi|239741684 PREDICTED: ankyrin repeat domain 36 [Homo sapiens]        41   0.003
gi|50083281 KIAA1853 protein [Homo sapiens]                            41   0.003
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]        41   0.003
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]    41   0.004

>gi|50363228 RAB11 family interacting protein 1 isoform 1 [Homo
           sapiens]
          Length = 649

 Score = 1268 bits (3281), Expect = 0.0
 Identities = 649/649 (100%), Positives = 649/649 (100%)

Query: 1   MSLMVSAGRGLGAVWSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERS 60
           MSLMVSAGRGLGAVWSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERS
Sbjct: 1   MSLMVSAGRGLGAVWSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERS 60

Query: 61  LGAPVWREEATFELPSLLSSGPAAAATLQLTVLHRALLGLDKFLGRAEVDLRDLHRDQGR 120
           LGAPVWREEATFELPSLLSSGPAAAATLQLTVLHRALLGLDKFLGRAEVDLRDLHRDQGR
Sbjct: 61  LGAPVWREEATFELPSLLSSGPAAAATLQLTVLHRALLGLDKFLGRAEVDLRDLHRDQGR 120

Query: 121 RKTQWYKLKSKPGKKDKERGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGK 180
           RKTQWYKLKSKPGKKDKERGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGK
Sbjct: 121 RKTQWYKLKSKPGKKDKERGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGK 180

Query: 181 NKDSGSDTASAIIPSTTPSVDSDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPT 240
           NKDSGSDTASAIIPSTTPSVDSDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPT
Sbjct: 181 NKDSGSDTASAIIPSTTPSVDSDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPT 240

Query: 241 SKPEKVLLRPGDFQSQWDEDDNEDESSSASDVMSHKRTASTDLKQLNQVNFTLPKKEGLS 300
           SKPEKVLLRPGDFQSQWDEDDNEDESSSASDVMSHKRTASTDLKQLNQVNFTLPKKEGLS
Sbjct: 241 SKPEKVLLRPGDFQSQWDEDDNEDESSSASDVMSHKRTASTDLKQLNQVNFTLPKKEGLS 300

Query: 301 FLGGLRSKNDVLSRSNVCINGNHVYLEQPEAKGEIKDSSPSSSPSPKGFRKKHLFSSTEN 360
           FLGGLRSKNDVLSRSNVCINGNHVYLEQPEAKGEIKDSSPSSSPSPKGFRKKHLFSSTEN
Sbjct: 301 FLGGLRSKNDVLSRSNVCINGNHVYLEQPEAKGEIKDSSPSSSPSPKGFRKKHLFSSTEN 360

Query: 361 LAAGSWKEPAEGGGLSSDRQLSESSTKDSLKSMTLPSYRPAPLVSGDLRENMAPANSEAT 420
           LAAGSWKEPAEGGGLSSDRQLSESSTKDSLKSMTLPSYRPAPLVSGDLRENMAPANSEAT
Sbjct: 361 LAAGSWKEPAEGGGLSSDRQLSESSTKDSLKSMTLPSYRPAPLVSGDLRENMAPANSEAT 420

Query: 421 KEAKESKKPESRRSSLLSLMTGKKDVAKGSEGENPLTVPGREKEGMLMGVKPGEDASGPA 480
           KEAKESKKPESRRSSLLSLMTGKKDVAKGSEGENPLTVPGREKEGMLMGVKPGEDASGPA
Sbjct: 421 KEAKESKKPESRRSSLLSLMTGKKDVAKGSEGENPLTVPGREKEGMLMGVKPGEDASGPA 480

Query: 481 EDLVRRSEKDTAAVVSRQGSSLNLFEDVQITEPEAEPESKSEPRPPISSPRAPQTRAVKP 540
           EDLVRRSEKDTAAVVSRQGSSLNLFEDVQITEPEAEPESKSEPRPPISSPRAPQTRAVKP
Sbjct: 481 EDLVRRSEKDTAAVVSRQGSSLNLFEDVQITEPEAEPESKSEPRPPISSPRAPQTRAVKP 540

Query: 541 RLHPVKPMNATATKVANCSLGTATIISENLNNEVMMKKYSPSDPAFAYAQLTHDELIQLV 600
           RLHPVKPMNATATKVANCSLGTATIISENLNNEVMMKKYSPSDPAFAYAQLTHDELIQLV
Sbjct: 541 RLHPVKPMNATATKVANCSLGTATIISENLNNEVMMKKYSPSDPAFAYAQLTHDELIQLV 600

Query: 601 LKQKETISKKEFQVRELEDYIDNLLVRVMEETPNILRIPTQVGKKAGKM 649
           LKQKETISKKEFQVRELEDYIDNLLVRVMEETPNILRIPTQVGKKAGKM
Sbjct: 601 LKQKETISKKEFQVRELEDYIDNLLVRVMEETPNILRIPTQVGKKAGKM 649


>gi|50659104 RAB11 family interacting protein 1 isoform 3 [Homo
           sapiens]
          Length = 1283

 Score = 1060 bits (2741), Expect = 0.0
 Identities = 544/552 (98%), Positives = 544/552 (98%)

Query: 1   MSLMVSAGRGLGAVWSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERS 60
           MSLMVSAGRGLGAVWSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERS
Sbjct: 1   MSLMVSAGRGLGAVWSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERS 60

Query: 61  LGAPVWREEATFELPSLLSSGPAAAATLQLTVLHRALLGLDKFLGRAEVDLRDLHRDQGR 120
           LGAPVWREEATFELPSLLSSGPAAAATLQLTVLHRALLGLDKFLGRAEVDLRDLHRDQGR
Sbjct: 61  LGAPVWREEATFELPSLLSSGPAAAATLQLTVLHRALLGLDKFLGRAEVDLRDLHRDQGR 120

Query: 121 RKTQWYKLKSKPGKKDKERGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGK 180
           RKTQWYKLKSKPGKKDKERGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGK
Sbjct: 121 RKTQWYKLKSKPGKKDKERGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGK 180

Query: 181 NKDSGSDTASAIIPSTTPSVDSDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPT 240
           NKDSGSDTASAIIPSTTPSVDSDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPT
Sbjct: 181 NKDSGSDTASAIIPSTTPSVDSDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPT 240

Query: 241 SKPEKVLLRPGDFQSQWDEDDNEDESSSASDVMSHKRTASTDLKQLNQVNFTLPKKEGLS 300
           SKPEKVLLRPGDFQSQWDEDDNEDESSSASDVMSHKRTASTDLKQLNQVNFTLPKKEGLS
Sbjct: 241 SKPEKVLLRPGDFQSQWDEDDNEDESSSASDVMSHKRTASTDLKQLNQVNFTLPKKEGLS 300

Query: 301 FLGGLRSKNDVLSRSNVCINGNHVYLEQPEAKGEIKDSSPSSSPSPKGFRKKHLFSSTEN 360
           FLGGLRSKNDVLSRSNVCINGNHVYLEQPEAKGEIKDSSPSSSPSPKGFRKKHLFSSTEN
Sbjct: 301 FLGGLRSKNDVLSRSNVCINGNHVYLEQPEAKGEIKDSSPSSSPSPKGFRKKHLFSSTEN 360

Query: 361 LAAGSWKEPAEGGGLSSDRQLSESSTKDSLKSMTLPSYRPAPLVSGDLRENMAPANSEAT 420
           LAAGSWKEPAEGGGLSSDRQLSESSTKDSLKSMTLPSYRPAPLVSGDLRENMAPANSEAT
Sbjct: 361 LAAGSWKEPAEGGGLSSDRQLSESSTKDSLKSMTLPSYRPAPLVSGDLRENMAPANSEAT 420

Query: 421 KEAKESKKPESRRSSLLSLMTGKKDVAKGSEGENPLTVPGREKEGMLMGVKPGEDASGPA 480
           KEAKESKKPESRRSSLLSLMTGKKDVAKGSEGENPLTVPGREKEGMLMGVKPGEDASGPA
Sbjct: 421 KEAKESKKPESRRSSLLSLMTGKKDVAKGSEGENPLTVPGREKEGMLMGVKPGEDASGPA 480

Query: 481 EDLVRRSEKDTAAVVSRQGSSLNLFEDVQITEPEAEPESKSEPRPPISSPRAPQTRAVKP 540
           EDLVRRSEKDTAAVVSRQGSSLNLFEDVQITEPEAEPESKSEPRPPISSPRAPQTRAVKP
Sbjct: 481 EDLVRRSEKDTAAVVSRQGSSLNLFEDVQITEPEAEPESKSEPRPPISSPRAPQTRAVKP 540

Query: 541 RLHPVKPMNATA 552
           RL        TA
Sbjct: 541 RLEVSPEAQPTA 552



 Score =  223 bits (569), Expect = 3e-58
 Identities = 138/248 (55%), Positives = 155/248 (62%), Gaps = 18/248 (7%)

Query: 415  ANSEATKEAKESKKPESRRSSLLSLMTGKKDVAKGSEGENPL------TVPGREKEGMLM 468
            A SE T E    K    + SSL   + G      G E E P+        PG   +  + 
Sbjct: 1041 APSEQTTEFGIHKPHLGKSSSLDKQLPGPS----GGEEEKPMGNGSPSPPPGTSLDNPVP 1096

Query: 469  GVKPGED-------ASGPAEDLVRRSEKDTAAVVSRQGSSLNLFEDVQITEPEAEPESKS 521
               P E         S    D    S  ++    + +GS+  + E+    +P  +     
Sbjct: 1097 SPSPSEIFPVTHSFPSSAHSDTHHTSTAESQKKATAEGSAGRV-ENFGKRKPLLQAWVSP 1155

Query: 522  EPRPPISSPRAPQTRAVKPRLHPVKPMNATATKVANCSLGTATIISENLNNEVMMKKYSP 581
                P+S+     T + K RLHPVKPMNATATKVANCSLGTATIISENLNNEVMMKKYSP
Sbjct: 1156 SETHPVSAQPGAGTGSAKHRLHPVKPMNATATKVANCSLGTATIISENLNNEVMMKKYSP 1215

Query: 582  SDPAFAYAQLTHDELIQLVLKQKETISKKEFQVRELEDYIDNLLVRVMEETPNILRIPTQ 641
            SDPAFAYAQLTHDELIQLVLKQKETISKKEFQVRELEDYIDNLLVRVMEETPNILRIPTQ
Sbjct: 1216 SDPAFAYAQLTHDELIQLVLKQKETISKKEFQVRELEDYIDNLLVRVMEETPNILRIPTQ 1275

Query: 642  VGKKAGKM 649
            VGKKAGKM
Sbjct: 1276 VGKKAGKM 1283


>gi|24308075 RAB11 family interacting protein 5 (class I) [Homo
           sapiens]
          Length = 653

 Score =  311 bits (797), Expect = 1e-84
 Identities = 238/669 (35%), Positives = 339/669 (50%), Gaps = 80/669 (11%)

Query: 15  WSPTHVQVTVLQARGLRAK--GPGGTSDAYAVIQVGKEKYATSVSERSLGAPVWREEATF 72
           W PTHVQVTVL+ARGLR K  G G TSDAY VIQVG+EKY+TSV E++ G P WREE +F
Sbjct: 16  WLPTHVQVTVLRARGLRGKSSGAGSTSDAYTVIQVGREKYSTSVVEKTHGCPEWREECSF 75

Query: 73  ELP-----SLL-----SSGPA-------AAATLQLTVLHRALLGLDKFLGRAEVDLRDLH 115
           ELP      LL      +GPA       AA  L LT +HR+L+G+DKFLG+A V L ++ 
Sbjct: 76  ELPPGALDGLLRAQEADAGPAPWAASSAAACELVLTTMHRSLIGVDKFLGQATVALDEVF 135

Query: 116 RDQGRRKTQWYKLKSKPGKKDKERGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKD 175
                + TQWYKL SKPGKK+KERGEIEV IQF RNN++ASMFDLSMKDK R+PF K++D
Sbjct: 136 GAGRAQHTQWYKLHSKPGKKEKERGEIEVTIQFTRNNLSASMFDLSMKDKPRSPFSKIRD 195

Query: 176 KIKGKNKDSGSDTASAIIPSTTPSVDSDDESVVK-DKKKKSKIKTLLSKSNLQK------ 228
           K+KGK K    ++ASAI+PS+    D D  S+ K  K K   ++  L KS+L +      
Sbjct: 196 KMKGKKK-YDLESASAILPSSAIE-DPDLGSLGKMGKAKGFFLRNKLRKSSLTQSNTSLG 253

Query: 229 --TPLSQSMSVLPTSKPEKVLLRPGDFQSQWDEDDNEDESSSASDVMSHKRTASTDLKQL 286
             + LS +   L    P   LL     +S W   +   +S+ +  + +HKRT S +  Q+
Sbjct: 254 SDSTLSSASGSLAYQGPGAELLTRSPSRSSWLSTEGGRDSAQSPKLFTHKRTYSDEANQM 313

Query: 287 NQVNFTLPKKEGLSFLGGLRSKNDVLSRSNVCINGNHVYLEQPEAKGEIKDSSPSSSPSP 346
                  P +  L   G L    D  SRS++C+NG+H+Y E+P+     + S   S PS 
Sbjct: 314 R----VAPPRALLDLQGHL----DAASRSSLCVNGSHIYNEEPQGPVRHRSSISGSLPSS 365

Query: 347 KGFRKKHLFSSTENLAA--GSWKEPAEGGGLSSDRQLSESSTKDSLKSMTLPSYRP---- 400
              +      S E   +   +W   +     SS+  L +       K +   +  P    
Sbjct: 366 GSLQAVSSRFSEEGPRSTDDTWPRGSRSNS-SSEAVLGQEELSAQAKVLAPGASHPGEEE 424

Query: 401 -APLVSGDLRENMAP--ANSEATKEAKESKKPESRRSSLLSLMTGKKDVAKGSEGENPLT 457
            A L  G   +   P  A+SEA  E KE  + E R+  +       + +++   G     
Sbjct: 425 GARLPEGKPVQVATPIVASSEAVAE-KEGARKEERKPRMGLFHHHHQGLSRSELGRRSSL 483

Query: 458 VPGREKEGMLMGVKPGEDASGPAEDLVRRSEKDTAAVVSRQGSSLNLFEDVQITE-PEAE 516
               EK G ++G  P   +SG  +                + S   L E    T+ P   
Sbjct: 484 ---GEKGGPILGASPHHSSSGEEK---------------AKSSWFGLREAKDPTQKPSPH 525

Query: 517 PESKSEPRPPISSPRAPQTR-----AVKPRLHPVKPMNATATK-VANCSLGTATIISENL 570
           P       P   SP   Q+R     A+   L  +K + + + + V         + ++ L
Sbjct: 526 PVKPLSAAPVEGSPDRKQSRSSLSIALSSGLEKLKTVTSGSIQPVTQAPQAGQMVDTKRL 585

Query: 571 NNEVMMKKYSPSDPAFAYAQLTHDELIQLVLKQKETISKKEFQVRELEDYIDNLLVRVME 630
            +  ++      D +  Y  LTHDELI L+L+++  +S+++  V+ELE YID LLVR+ME
Sbjct: 586 KDSAVL------DQSAKYYHLTHDELISLLLQRERELSQRDEHVQELESYIDRLLVRIME 639

Query: 631 ETPNILRIP 639
            +P +L+IP
Sbjct: 640 TSPTLLQIP 648


>gi|7662394 RAB11 family interacting protein 2 (class I) [Homo
           sapiens]
          Length = 512

 Score =  253 bits (646), Expect = 4e-67
 Identities = 160/345 (46%), Positives = 208/345 (60%), Gaps = 21/345 (6%)

Query: 15  WSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERSLGAPVWREEATFEL 74
           W PTHVQVTVLQA+ L+ KG  GT+D Y +IQ+GKEKY+TSV+E++L  PVW+EEA+FEL
Sbjct: 10  WFPTHVQVTVLQAKDLKPKGKSGTNDTYTIIQLGKEKYSTSVAEKTL-EPVWKEEASFEL 68

Query: 75  PSLLSSGPAAAATLQLTVLHRALLGLDKFLGRAEVDLRDLHRDQGRRKTQWYKLKSKPGK 134
           P LL  G      L L V+HR+L+GLDKFLG+  ++L D+  D+ RRKT+W++L+SK GK
Sbjct: 69  PGLLIQGSPEKYILFLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWFRLESKQGK 128

Query: 135 KDKERGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKG-KNKDSGSDTASAII 193
           + K RGEI+V+IQFMRNNMTASMFDLSMKDK+R+PF KLKDK+KG KN  + SDT+SAII
Sbjct: 129 RIKNRGEIKVNIQFMRNNMTASMFDLSMKDKTRSPFAKLKDKMKGRKNDGTFSDTSSAII 188

Query: 194 PST-TPSVDSDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPTSKPEKVLLRPGD 252
           PST  P  +S+  S     K K K   LL    L     + SMS L  S      L+ G 
Sbjct: 189 PSTHMPDANSEFSSGEIQMKSKPKKPFLLGPQRLSS---AHSMSDLSGSHMSSEKLKAGT 245

Query: 253 FQS------QWDEDDNEDESSSASDVMSHKRTASTDLKQLNQVNFTLPKKEGLSFLGGLR 306
                    Q D      ES S      H+RT S D  ++NQ +  + + E L F     
Sbjct: 246 IGQTHLLGHQLDSFGTVPESGSLKS--PHRRTLSFDTSKMNQPDSIVDEGE-LCF----G 298

Query: 307 SKNDVLSRSNVCINGNHVYLEQPEAKGEIKDSSPSSSPSPKGFRK 351
            +ND    +NV  +    +   P  K   ++SS +   S   F K
Sbjct: 299 RQNDPF--TNVTASLPQKFATLPRKKNPFEESSETWDSSMNLFSK 341



 Score = 83.6 bits (205), Expect = 5e-16
 Identities = 38/69 (55%), Positives = 53/69 (76%)

Query: 580 SPSDPAFAYAQLTHDELIQLVLKQKETISKKEFQVRELEDYIDNLLVRVMEETPNILRIP 639
           +P D    Y  LT++E++Q ++K KE + +K+  +RELEDYIDNLLVRVMEETP+ILR+P
Sbjct: 440 NPFDATAGYRSLTYEEVLQELVKHKELLRRKDTHIRELEDYIDNLLVRVMEETPSILRVP 499

Query: 640 TQVGKKAGK 648
            +  +KAGK
Sbjct: 500 YEPSRKAGK 508


>gi|50363230 RAB11 family interacting protein 1 isoform 2 [Homo
           sapiens]
          Length = 612

 Score =  221 bits (563), Expect = 2e-57
 Identities = 137/248 (55%), Positives = 154/248 (62%), Gaps = 18/248 (7%)

Query: 415 ANSEATKEAKESKKPESRRSSLLSLMTGKKDVAKGSEGENPL------TVPGREKEGMLM 468
           A SE T E    K    + SSL   + G      G E E P+        PG   +  + 
Sbjct: 370 APSEQTTEFGIHKPHLGKSSSLDKQLPGPS----GGEEEKPMGNGSPSPPPGTSLDNPVP 425

Query: 469 GVKPGED-------ASGPAEDLVRRSEKDTAAVVSRQGSSLNLFEDVQITEPEAEPESKS 521
              P E         S    D    S  ++    + +GS+  + E+    +P  +     
Sbjct: 426 SPSPSEIFPVTHSFPSSAHSDTHHTSTAESQKKATAEGSAGRV-ENFGKRKPLLQAWVSP 484

Query: 522 EPRPPISSPRAPQTRAVKPRLHPVKPMNATATKVANCSLGTATIISENLNNEVMMKKYSP 581
               P+S+     T + K RLHPVKPMNA ATKVANCSLGTATIISENLNNEVMMKKYSP
Sbjct: 485 SETHPVSAQPGAGTGSAKHRLHPVKPMNAMATKVANCSLGTATIISENLNNEVMMKKYSP 544

Query: 582 SDPAFAYAQLTHDELIQLVLKQKETISKKEFQVRELEDYIDNLLVRVMEETPNILRIPTQ 641
           SDPAFAYAQLTHDELIQLVLKQKETISKKEFQVRELEDYIDNLLVRVMEETPNILRIPTQ
Sbjct: 545 SDPAFAYAQLTHDELIQLVLKQKETISKKEFQVRELEDYIDNLLVRVMEETPNILRIPTQ 604

Query: 642 VGKKAGKM 649
           VGKKAGKM
Sbjct: 605 VGKKAGKM 612


>gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo
           sapiens]
          Length = 778

 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 30/99 (30%), Positives = 49/99 (49%), Gaps = 7/99 (7%)

Query: 20  VQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERSLGAPVWREEATFELPSLLS 79
           V +T+++ R L+A    G SD Y   ++G +KY + +  ++L  P WRE+  F L     
Sbjct: 251 VSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLN-PQWREQFDFHLYE--- 306

Query: 80  SGPAAAATLQLTVLHRALLGLDKFLGRAEVDLRDLHRDQ 118
                   + +T   +     D F+GR +VDL  L R+Q
Sbjct: 307 ---ERGGVIDITAWDKDAGKRDDFIGRCQVDLSALSREQ 342



 Score = 38.5 bits (88), Expect = 0.020
 Identities = 28/96 (29%), Positives = 46/96 (47%), Gaps = 9/96 (9%)

Query: 20  VQVTVLQARGLRAKGPGGTSDAYAVIQV-GKEKYATSVSERSLGAPVWREEATFELPSLL 78
           + +T+ + + L A+  GGTSD Y   ++ GKE + + +  ++L  PVW E+A   +  L 
Sbjct: 42  LDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSKIIHKNLN-PVWEEKACILVDHL- 99

Query: 79  SSGPAAAATLQLTVLHRALLGLDKFLGRAEVDLRDL 114
                    L + V        D F+G A +DL  L
Sbjct: 100 ------REPLYIKVFDYDFGLQDDFMGSAFLDLTQL 129


>gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Homo
           sapiens]
          Length = 999

 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 30/99 (30%), Positives = 49/99 (49%), Gaps = 7/99 (7%)

Query: 20  VQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERSLGAPVWREEATFELPSLLS 79
           V +T+++ R L+A    G SD Y   ++G +KY + +  ++L  P WRE+  F L     
Sbjct: 472 VSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLN-PQWREQFDFHLYE--- 527

Query: 80  SGPAAAATLQLTVLHRALLGLDKFLGRAEVDLRDLHRDQ 118
                   + +T   +     D F+GR +VDL  L R+Q
Sbjct: 528 ---ERGGVIDITAWDKDAGKRDDFIGRCQVDLSALSREQ 563



 Score = 38.5 bits (88), Expect = 0.020
 Identities = 28/96 (29%), Positives = 46/96 (47%), Gaps = 9/96 (9%)

Query: 20  VQVTVLQARGLRAKGPGGTSDAYAVIQV-GKEKYATSVSERSLGAPVWREEATFELPSLL 78
           + +T+ + + L A+  GGTSD Y   ++ GKE + + +  ++L  PVW E+A   +  L 
Sbjct: 263 LDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSKIIHKNLN-PVWEEKACILVDHL- 320

Query: 79  SSGPAAAATLQLTVLHRALLGLDKFLGRAEVDLRDL 114
                    L + V        D F+G A +DL  L
Sbjct: 321 ------REPLYIKVFDYDFGLQDDFMGSAFLDLTQL 350


>gi|122937247 unc-13 homolog A [Homo sapiens]
          Length = 1791

 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 40/126 (31%), Positives = 57/126 (45%), Gaps = 14/126 (11%)

Query: 15  WSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERSLGAPVWREEATFEL 74
           WS   + +TV+ A+GL+AK   G+SD Y  +QVGK K  T     +L  PVW E   FE 
Sbjct: 762 WS-AKISITVVCAQGLQAKDKTGSSDPYVTVQVGKTKKRTKTIYGNLN-PVWEENFHFEC 819

Query: 75  PSLLSSGPAAAAT------LQLTVLHRALLGLDKFLGRAEVDLRDLHRDQGRRKTQWYKL 128
            +  SS             ++  V  R     D FLG+  +++R L  +       WY L
Sbjct: 820 HN--SSDRIKVRVWDEDDDIKSRVKQRFKRESDDFLGQTIIEVRTLSGEM----DVWYNL 873

Query: 129 KSKPGK 134
             +  K
Sbjct: 874 DKRTDK 879


>gi|122937514 unc-13 homolog C [Homo sapiens]
          Length = 2214

 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 38/124 (30%), Positives = 56/124 (45%), Gaps = 10/124 (8%)

Query: 15   WSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERSLGAPVWREEATFEL 74
            WS   + +TV+ A+GL+AK   G+SD Y  +QVGK K  T     +L  PVW E+  FE 
Sbjct: 1218 WS-AKITITVVSAQGLQAKDKTGSSDPYVTVQVGKNKRRTKTIFGNLN-PVWDEKFYFEC 1275

Query: 75   PSLLSSGPAAA----ATLQLTVLHRALLGLDKFLGRAEVDLRDLHRDQGRRKTQWYKLKS 130
             +               ++  V        D FLG+  V++R L  +       WY L+ 
Sbjct: 1276 HNSTDRIKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTLSGEM----DVWYNLEK 1331

Query: 131  KPGK 134
            +  K
Sbjct: 1332 RTDK 1335


>gi|110611226 UNC13 (C. elegans)-like [Homo sapiens]
          Length = 1591

 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 39/126 (30%), Positives = 58/126 (46%), Gaps = 14/126 (11%)

Query: 15  WSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERSLGAPVWREEATFEL 74
           WS   + +TV+ A+GL+AK   G+SD Y  +QV K K  T     +L  PVW E+  FE 
Sbjct: 598 WS-AKITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLN-PVWEEKFHFEC 655

Query: 75  PSLLSSGPAAAAT------LQLTVLHRALLGLDKFLGRAEVDLRDLHRDQGRRKTQWYKL 128
            +  SS             ++  V  R     D FLG+  +++R L  +       WY L
Sbjct: 656 HN--SSDRIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEM----DVWYNL 709

Query: 129 KSKPGK 134
           + +  K
Sbjct: 710 EKRTDK 715


>gi|92859638 synaptotagmin V [Homo sapiens]
          Length = 386

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 41/162 (25%), Positives = 74/162 (45%), Gaps = 20/162 (12%)

Query: 22  VTVLQARGLRAKGPGGTSDAYAVIQV---GKEKYATSVSERSLGAPVWREEATFELPSLL 78
           V +LQA GL A   GG+SD Y  + +    + +Y T V  ++L  P + E   F++P + 
Sbjct: 127 VGILQAMGLAALDLGGSSDPYVRVYLLPDKRRRYETKVHRQTLN-PHFGETFAFKVPYVE 185

Query: 79  SSGPAAAATLQLTVLHRALLGLDKF-----LGRAEVDLRDLHRDQGRRKTQWYKLKSKPG 133
             G          VL  A+   D+F     +G   V +  +  D GR    W +L++ P 
Sbjct: 186 LGG---------RVLVMAVYDFDRFSRNDAIGEVRVPMSSV--DLGRPVQAWRELQAAPR 234

Query: 134 KKDKERGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKD 175
           ++ ++ G+I   ++++      ++  L  K+  +   G L D
Sbjct: 235 EEQEKLGDICFSLRYVPTAGKLTVIVLEAKNLKKMDVGGLSD 276



 Score = 39.3 bits (90), Expect = 0.011
 Identities = 35/123 (28%), Positives = 57/123 (46%), Gaps = 20/123 (16%)

Query: 22  VTVLQARGLRAKGPGGTSDAYA---VIQVGKE--KYATSVSERSLGAPVWREEATFELPS 76
           V VL+A+ L+    GG SD Y    ++Q GK+  K  T++ + +L  P + E  +FE+P 
Sbjct: 258 VIVLEAKNLKKMDVGGLSDPYVKVHLLQGGKKVRKKKTTIKKNTLN-PYYNEAFSFEVP- 315

Query: 77  LLSSGPAAAATLQLTVLHRALLGLDKFLGRAEVDL----------RDLHRDQGRRKTQWY 126
                      ++LTVL    LG ++ +GR  V             D+  +  R   QW+
Sbjct: 316 ---CDQVQKVQVELTVLDYDKLGKNEAIGRVAVGAAAGGAGLRHWADMLANPRRPIAQWH 372

Query: 127 KLK 129
            L+
Sbjct: 373 SLR 375


>gi|209447073 synaptotagmin I [Homo sapiens]
          Length = 422

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 40/157 (25%), Positives = 72/157 (45%), Gaps = 10/157 (6%)

Query: 22  VTVLQARGLRAKGPGGTSDAYA---VIQVGKEKYATSVSERSLGAPVWREEATFELPSLL 78
           V ++QA  L A   GGTSD Y    ++   K+K+ T V  ++L  PV+ E+ TF++P   
Sbjct: 161 VGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKFETKVHRKTLN-PVFNEQFTFKVPYSE 219

Query: 79  SSGPAAAATLQLTVLHRALLGLDKFLGRAEVDLRDLHRDQGRRKTQWYKLKSKPGKKDKE 138
             G     TL + V           +G  +V +  +  D G    +W  L+S   ++ ++
Sbjct: 220 LGG----KTLVMAVYDFDRFSKHDIIGEFKVPMNTV--DFGHVTEEWRDLQSAEKEEQEK 273

Query: 139 RGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKD 175
            G+I   ++++      ++  L  K+  +   G L D
Sbjct: 274 LGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSD 310



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 30/129 (23%), Positives = 58/129 (44%), Gaps = 14/129 (10%)

Query: 22  VTVLQARGLRAKGPGGTSDAYA---VIQVGK--EKYATSVSERSLGAPVWREEATFELPS 76
           V +L+A+ L+    GG SD Y    ++Q GK  +K  T++ + +L  P + E  +FE+P 
Sbjct: 292 VVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLN-PYYNESFSFEVP- 349

Query: 77  LLSSGPAAAATLQLTVLHRALLGLDKFLGRAEVDLRDLHRDQGRRKTQWYKLKSKPGKKD 136
                      + +TVL    +G +  +G+  V     +   G     W  + + P +  
Sbjct: 350 ---FEQIQKVQVVVTVLDYDKIGKNDAIGKVFVG----YNSTGAELRHWSDMLANPRRPI 402

Query: 137 KERGEIEVD 145
            +   ++V+
Sbjct: 403 AQWHTLQVE 411


>gi|5032139 synaptotagmin I [Homo sapiens]
          Length = 422

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 40/157 (25%), Positives = 72/157 (45%), Gaps = 10/157 (6%)

Query: 22  VTVLQARGLRAKGPGGTSDAYA---VIQVGKEKYATSVSERSLGAPVWREEATFELPSLL 78
           V ++QA  L A   GGTSD Y    ++   K+K+ T V  ++L  PV+ E+ TF++P   
Sbjct: 161 VGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKFETKVHRKTLN-PVFNEQFTFKVPYSE 219

Query: 79  SSGPAAAATLQLTVLHRALLGLDKFLGRAEVDLRDLHRDQGRRKTQWYKLKSKPGKKDKE 138
             G     TL + V           +G  +V +  +  D G    +W  L+S   ++ ++
Sbjct: 220 LGG----KTLVMAVYDFDRFSKHDIIGEFKVPMNTV--DFGHVTEEWRDLQSAEKEEQEK 273

Query: 139 RGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKD 175
            G+I   ++++      ++  L  K+  +   G L D
Sbjct: 274 LGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSD 310



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 30/129 (23%), Positives = 58/129 (44%), Gaps = 14/129 (10%)

Query: 22  VTVLQARGLRAKGPGGTSDAYA---VIQVGK--EKYATSVSERSLGAPVWREEATFELPS 76
           V +L+A+ L+    GG SD Y    ++Q GK  +K  T++ + +L  P + E  +FE+P 
Sbjct: 292 VVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLN-PYYNESFSFEVP- 349

Query: 77  LLSSGPAAAATLQLTVLHRALLGLDKFLGRAEVDLRDLHRDQGRRKTQWYKLKSKPGKKD 136
                      + +TVL    +G +  +G+  V     +   G     W  + + P +  
Sbjct: 350 ---FEQIQKVQVVVTVLDYDKIGKNDAIGKVFVG----YNSTGAELRHWSDMLANPRRPI 402

Query: 137 KERGEIEVD 145
            +   ++V+
Sbjct: 403 AQWHTLQVE 411


>gi|209447070 synaptotagmin I [Homo sapiens]
          Length = 422

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 40/157 (25%), Positives = 72/157 (45%), Gaps = 10/157 (6%)

Query: 22  VTVLQARGLRAKGPGGTSDAYA---VIQVGKEKYATSVSERSLGAPVWREEATFELPSLL 78
           V ++QA  L A   GGTSD Y    ++   K+K+ T V  ++L  PV+ E+ TF++P   
Sbjct: 161 VGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKFETKVHRKTLN-PVFNEQFTFKVPYSE 219

Query: 79  SSGPAAAATLQLTVLHRALLGLDKFLGRAEVDLRDLHRDQGRRKTQWYKLKSKPGKKDKE 138
             G     TL + V           +G  +V +  +  D G    +W  L+S   ++ ++
Sbjct: 220 LGG----KTLVMAVYDFDRFSKHDIIGEFKVPMNTV--DFGHVTEEWRDLQSAEKEEQEK 273

Query: 139 RGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKD 175
            G+I   ++++      ++  L  K+  +   G L D
Sbjct: 274 LGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSD 310



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 30/129 (23%), Positives = 58/129 (44%), Gaps = 14/129 (10%)

Query: 22  VTVLQARGLRAKGPGGTSDAYA---VIQVGK--EKYATSVSERSLGAPVWREEATFELPS 76
           V +L+A+ L+    GG SD Y    ++Q GK  +K  T++ + +L  P + E  +FE+P 
Sbjct: 292 VVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLN-PYYNESFSFEVP- 349

Query: 77  LLSSGPAAAATLQLTVLHRALLGLDKFLGRAEVDLRDLHRDQGRRKTQWYKLKSKPGKKD 136
                      + +TVL    +G +  +G+  V     +   G     W  + + P +  
Sbjct: 350 ---FEQIQKVQVVVTVLDYDKIGKNDAIGKVFVG----YNSTGAELRHWSDMLANPRRPI 402

Query: 137 KERGEIEVD 145
            +   ++V+
Sbjct: 403 AQWHTLQVE 411


>gi|4759026 RAS protein activator like 1 [Homo sapiens]
          Length = 804

 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 40/133 (30%), Positives = 60/133 (45%), Gaps = 11/133 (8%)

Query: 20  VQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYA-TSVSERSLGAPVWREEATFELPSLL 78
           + V V++ R L AK   G+SD Y +++V  E  A T+   RSLG P W EE T  LP   
Sbjct: 7   LNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLG-PFWGEEYTVHLPLDF 65

Query: 79  SSGPAAAATLQLTVLHRALLGLDKFLGRAEVDLRDLHRDQGRRKTQWYKLKSKPGKKDKE 138
                    L   VL    +G D  +G+  +    +  D  R    W  L S+     + 
Sbjct: 66  HQ-------LAFYVLDEDTVGHDDIIGKISLSREAITADP-RGIDSWINL-SRVDPDAEV 116

Query: 139 RGEIEVDIQFMRN 151
           +GEI + +Q + +
Sbjct: 117 QGEICLSVQMLED 129


>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
           sapiens]
          Length = 699

 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 66/273 (24%), Positives = 112/273 (41%), Gaps = 40/273 (14%)

Query: 199 SVDSDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPTSKP-------EKVLLRPG 251
           S DS D    +D +  SK       S+ +    ++S +V P + P       +K+L R  
Sbjct: 362 SSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKA 421

Query: 252 DFQSQWDEDDNEDESSSASDVMSHKRTASTDLKQLNQVNFTLPKKEGLSFLGGLRSKNDV 311
           D  S      +E+ESSS+ +  + K  A+T  K   +   +LP K+     G   S +D 
Sbjct: 422 DSSS------SEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQ--GSRDSSSDS 473

Query: 312 LSRSNVCINGNHVYLEQPEAKGEIKDSSPSSSPSPKGFRKKHLFSSTENLAAGSWKEPAE 371
            S S+          E+ E K        +S  + K   +K    +  +  A + K  AE
Sbjct: 474 DSSSS----------EEEEEK--------TSKSAVKKKPQKVAGGAAPSKPASAKKGKAE 515

Query: 372 GGGLSSDRQLSESSTKDSLKSMTLPSYRP-APLVSGDLRENMAPANSEATKEAKESKKPE 430
               SS    SE   ++ LK    P  RP AP  +G     +   N +A K ++E ++ E
Sbjct: 516 SSNSSSSDDSSEEE-EEKLKGKGSP--RPQAPKANG--TSALTAQNGKAAKNSEEEEE-E 569

Query: 431 SRRSSLLSLMTGKKDVAKGSEGENPLTVPGREK 463
            ++++++   +G     K +E       P  +K
Sbjct: 570 KKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKK 602



 Score = 36.2 bits (82), Expect = 0.097
 Identities = 93/500 (18%), Positives = 176/500 (35%), Gaps = 52/500 (10%)

Query: 125 WYKLKSKPGKKDKERGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGKNKDS 184
           W K    P +K +  G +    +  +   ++   D S +++        K  +  K    
Sbjct: 57  WLKSAKVPERKLQANGPVAKKAK--KKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGL 114

Query: 185 GSDTASAIIPSTTPSVDSDDESVVKDKKKKSKIKTLLSKSNLQKTPL---------SQSM 235
               A+A    ++ S +S D+   +D+KK+   K +  ++   K P          S S 
Sbjct: 115 PPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSS 174

Query: 236 SVLPTSKPEKVLLRPGDFQSQWD------------------EDDNEDESSSASDVMSHKR 277
           S     K +K  + P   ++Q                       +   SSS+SD    ++
Sbjct: 175 SEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEK 234

Query: 278 TASTDLKQLNQVNFTLPKKEGLSFLGGLRSKNDVLSRSNVCINGNHVYLEQPEAKGEIKD 337
            A+T  K       T+PKK+ ++    +++      +S+   + +    E+ +   + K 
Sbjct: 235 AAATPKK-------TVPKKQVVA-KAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKP 286

Query: 338 SSPSSSPSPKGFRKKHLFSSTENLAAGSWKEPAEGGGLSSDRQLSESSTKDSLKSMTLPS 397
              SS P P     K    +     A   ++P E    SSD   S+SS+++  K  T   
Sbjct: 287 GPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDE--SDSSSEEEKKPPTKAV 344

Query: 398 YRPAPLVSGDLRENMAPANSEATKEAKESKKPESRRSSLLSLMTGKKDVAKGSEGENPLT 457
              A       ++    ++  +  ++ E  +  S+ +      + K  V   S    P  
Sbjct: 345 VSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAA 404

Query: 458 VPGREKEGMLMGVKPGEDASGPAEDLVRRSEKDTAAVVSRQGSSLNLFEDVQI---TEPE 514
            P +   G    +    D+S   E+     E+ T  +V+           + +     P+
Sbjct: 405 APKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQ 464

Query: 515 AEPESKSEPRPPISSPRAPQT--RAVKPR-------LHPVKPMNATATKVANCSLGTATI 565
              +S S+     S     +T   AVK +         P KP +A   K  + +  ++  
Sbjct: 465 GSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDD 524

Query: 566 ISENLNNEVMMKKYSPSDPA 585
            SE    E +  K SP   A
Sbjct: 525 SSEE-EEEKLKGKGSPRPQA 543



 Score = 35.0 bits (79), Expect = 0.22
 Identities = 32/143 (22%), Positives = 55/143 (38%), Gaps = 5/143 (3%)

Query: 402 PLVSGDLRENMAPANSEATKEAKESKKPESRRSSLLSLMTGKKDVAKGSEGENPLTVPGR 461
           PLV G LR+N     +    +A  + + ++  SSLL + +     AK  E +     P  
Sbjct: 16  PLVLGFLRDNQLSEVANKFAKATGATQQDANASSLLDIYSFWLKSAKVPERKLQANGPVA 75

Query: 462 EKEGMLMGVKPGEDASGPAEDLVRRSEKDTAAVVSRQG-----SSLNLFEDVQITEPEAE 516
           +K          ED+S   E++     K  A    R G     ++    E     E   +
Sbjct: 76  KKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDD 135

Query: 517 PESKSEPRPPISSPRAPQTRAVK 539
            + + + + P+     PQ +A K
Sbjct: 136 DDEEDQKKQPVQKGVKPQAKAAK 158


>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
          Length = 1670

 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 29/99 (29%), Positives = 44/99 (44%), Gaps = 7/99 (7%)

Query: 20   VQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERSLGAPVWREEATFELPSLLS 79
            + V V++A  L+A  P G S+ Y  I +G + Y T   + +L  P W     F +  L  
Sbjct: 1544 LMVHVIEATELKACKPNGKSNPYCEISMGSQSYTTRTIQDTLN-PKWNFNCQFFIKDLYQ 1602

Query: 80   SGPAAAATLQLTVLHRALLGLDKFLGRAEVDLRDLHRDQ 118
                    L LT+  R     D FLGR E+ +  +  +Q
Sbjct: 1603 D------VLCLTLFDRDQFSPDDFLGRTEIPVAKIRTEQ 1635


>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
          Length = 1697

 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 29/99 (29%), Positives = 44/99 (44%), Gaps = 7/99 (7%)

Query: 20   VQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERSLGAPVWREEATFELPSLLS 79
            + V V++A  L+A  P G S+ Y  I +G + Y T   + +L  P W     F +  L  
Sbjct: 1571 LMVHVIEATELKACKPNGKSNPYCEISMGSQSYTTRTIQDTLN-PKWNFNCQFFIKDLYQ 1629

Query: 80   SGPAAAATLQLTVLHRALLGLDKFLGRAEVDLRDLHRDQ 118
                    L LT+  R     D FLGR E+ +  +  +Q
Sbjct: 1630 D------VLCLTLFDRDQFSPDDFLGRTEIPVAKIRTEQ 1662


>gi|211059429 synaptotagmin II [Homo sapiens]
          Length = 419

 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 40/157 (25%), Positives = 70/157 (44%), Gaps = 10/157 (6%)

Query: 22  VTVLQARGLRAKGPGGTSDAYA---VIQVGKEKYATSVSERSLGAPVWREEATFELPSLL 78
           V VLQA  L A   GGTSD Y    ++   K+KY T V  ++L  P + E  TF++P   
Sbjct: 158 VGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTLN-PAFNETFTFKVPYQE 216

Query: 79  SSGPAAAATLQLTVLHRALLGLDKFLGRAEVDLRDLHRDQGRRKTQWYKLKSKPGKKDKE 138
             G     TL + +           +G  +V +  +  D G+   +W  L+    ++ ++
Sbjct: 217 LGG----KTLVMAIYDFDRFSKHDIIGEVKVPMNTV--DLGQPIEEWRDLQGGEKEEPEK 270

Query: 139 RGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKD 175
            G+I   ++++      ++  L  K+  +   G L D
Sbjct: 271 LGDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSD 307



 Score = 36.2 bits (82), Expect = 0.097
 Identities = 36/123 (29%), Positives = 60/123 (48%), Gaps = 20/123 (16%)

Query: 22  VTVLQARGLRAKGPGGTSDAYA---VIQVGK--EKYATSVSERSLGAPVWREEATFELPS 76
           V +L+A+ L+    GG SD Y    ++Q GK  +K  T+V +++L  P + E  +FE+P 
Sbjct: 289 VCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLN-PYFNESFSFEIP- 346

Query: 77  LLSSGPAAAATLQLTVLHRALLGLDKFLGRAEV-------DLR---DLHRDQGRRKTQWY 126
                      + +TVL    LG ++ +G+  V       +LR   D+  +  R   QW+
Sbjct: 347 ---FEQIQKVQVVVTVLDYDKLGKNEAIGKIFVGSNATGTELRHWSDMLANPRRPIAQWH 403

Query: 127 KLK 129
            LK
Sbjct: 404 SLK 406


>gi|31543670 synaptotagmin II [Homo sapiens]
          Length = 419

 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 40/157 (25%), Positives = 70/157 (44%), Gaps = 10/157 (6%)

Query: 22  VTVLQARGLRAKGPGGTSDAYA---VIQVGKEKYATSVSERSLGAPVWREEATFELPSLL 78
           V VLQA  L A   GGTSD Y    ++   K+KY T V  ++L  P + E  TF++P   
Sbjct: 158 VGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTLN-PAFNETFTFKVPYQE 216

Query: 79  SSGPAAAATLQLTVLHRALLGLDKFLGRAEVDLRDLHRDQGRRKTQWYKLKSKPGKKDKE 138
             G     TL + +           +G  +V +  +  D G+   +W  L+    ++ ++
Sbjct: 217 LGG----KTLVMAIYDFDRFSKHDIIGEVKVPMNTV--DLGQPIEEWRDLQGGEKEEPEK 270

Query: 139 RGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKD 175
            G+I   ++++      ++  L  K+  +   G L D
Sbjct: 271 LGDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSD 307



 Score = 36.2 bits (82), Expect = 0.097
 Identities = 36/123 (29%), Positives = 60/123 (48%), Gaps = 20/123 (16%)

Query: 22  VTVLQARGLRAKGPGGTSDAYA---VIQVGK--EKYATSVSERSLGAPVWREEATFELPS 76
           V +L+A+ L+    GG SD Y    ++Q GK  +K  T+V +++L  P + E  +FE+P 
Sbjct: 289 VCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLN-PYFNESFSFEIP- 346

Query: 77  LLSSGPAAAATLQLTVLHRALLGLDKFLGRAEV-------DLR---DLHRDQGRRKTQWY 126
                      + +TVL    LG ++ +G+  V       +LR   D+  +  R   QW+
Sbjct: 347 ---FEQIQKVQVVVTVLDYDKLGKNEAIGKIFVGSNATGTELRHWSDMLANPRRPIAQWH 403

Query: 127 KLK 129
            LK
Sbjct: 404 SLK 406


>gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2
           [Homo sapiens]
          Length = 1481

 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 102/445 (22%), Positives = 164/445 (36%), Gaps = 79/445 (17%)

Query: 163 KDKSR---NPFGKLKDKIKGKNKDSGSDT-----ASAIIPSTTPSVDS--DDESVVKDKK 212
           K+KS+   +  G +KD+I G +K S  +T     A     S+  S  S    E   K+++
Sbjct: 130 KEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERE 189

Query: 213 KKSKIKTLLSKSNLQKTPLSQSMSVLPTSKPEKVLLRPGDFQSQ----------WDEDDN 262
            KS  K        ++TP S      P  +      +  D   Q           D D +
Sbjct: 190 LKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLS 249

Query: 263 EDESSSASDVMSHKRT-ASTDLKQLNQVNFTLPKKEGLSFLGGLRSKNDVLSRSNVCING 321
              S ++S+  S+K++  ST  +Q    + + P KE  ++    RS +    R       
Sbjct: 250 PSRSHTSSNYDSYKKSPGSTSRRQ----SVSPPYKEPSAYQSSTRSPSPYSRRQ----RS 301

Query: 322 NHVYLEQPEAKGEIKDSSPSSSPSPKGFRKKHL-FSSTENLAAGSWKEPAEGGGLSSDRQ 380
              Y  +  +  E   S    SPSP G R+    F S  +L+             S    
Sbjct: 302 VSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSPA 361

Query: 381 LSESSTKDSLKSMTLPSYRPAPLVSGDLRENMAPANSEATKEAKESKKPESRRSSLLSLM 440
            S  S+  S K  +    R + +    L     P NS    E    KK E   ++  + M
Sbjct: 362 YSRHSSSHSKKKRSSSRSRHSSISPVRL-----PLNSSLGAELSRKKK-ERAAAAAAAKM 415

Query: 441 TGKKDVAKGSEGENPLTVPGREK---EGMLMGVKPGE-------DASGPAEDLVR----- 485
            GK+  +KGS    P+ +P +E    E    G++  +       + S P  +LV      
Sbjct: 416 DGKE--SKGS----PVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLN 469

Query: 486 ---RSEKDTAAVVSRQGSSLNLFEDVQ----------------ITEPEAEPESKS--EPR 524
              ++  DT  V   + S  +L +D++                +T  E E   K    P 
Sbjct: 470 TEVKNSSDTGKVKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPL 529

Query: 525 PPISSPRAP-QTRAVKPRLHPVKPM 548
           P I+SP  P  T    P+  P+ P+
Sbjct: 530 PTIASPPPPLPTTTPPPQTPPLPPL 554


>gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1
           [Homo sapiens]
          Length = 1490

 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 102/445 (22%), Positives = 164/445 (36%), Gaps = 79/445 (17%)

Query: 163 KDKSR---NPFGKLKDKIKGKNKDSGSDT-----ASAIIPSTTPSVDS--DDESVVKDKK 212
           K+KS+   +  G +KD+I G +K S  +T     A     S+  S  S    E   K+++
Sbjct: 130 KEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERE 189

Query: 213 KKSKIKTLLSKSNLQKTPLSQSMSVLPTSKPEKVLLRPGDFQSQ----------WDEDDN 262
            KS  K        ++TP S      P  +      +  D   Q           D D +
Sbjct: 190 LKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLS 249

Query: 263 EDESSSASDVMSHKRT-ASTDLKQLNQVNFTLPKKEGLSFLGGLRSKNDVLSRSNVCING 321
              S ++S+  S+K++  ST  +Q    + + P KE  ++    RS +    R       
Sbjct: 250 PSRSHTSSNYDSYKKSPGSTSRRQ----SVSPPYKEPSAYQSSTRSPSPYSRRQ----RS 301

Query: 322 NHVYLEQPEAKGEIKDSSPSSSPSPKGFRKKHL-FSSTENLAAGSWKEPAEGGGLSSDRQ 380
              Y  +  +  E   S    SPSP G R+    F S  +L+             S    
Sbjct: 302 VSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSPA 361

Query: 381 LSESSTKDSLKSMTLPSYRPAPLVSGDLRENMAPANSEATKEAKESKKPESRRSSLLSLM 440
            S  S+  S K  +    R + +    L     P NS    E    KK E   ++  + M
Sbjct: 362 YSRHSSSHSKKKRSSSRSRHSSISPVRL-----PLNSSLGAELSRKKK-ERAAAAAAAKM 415

Query: 441 TGKKDVAKGSEGENPLTVPGREK---EGMLMGVKPGE-------DASGPAEDLVR----- 485
            GK+  +KGS    P+ +P +E    E    G++  +       + S P  +LV      
Sbjct: 416 DGKE--SKGS----PVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLN 469

Query: 486 ---RSEKDTAAVVSRQGSSLNLFEDVQ----------------ITEPEAEPESKS--EPR 524
              ++  DT  V   + S  +L +D++                +T  E E   K    P 
Sbjct: 470 TEVKNSSDTGKVKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPL 529

Query: 525 PPISSPRAP-QTRAVKPRLHPVKPM 548
           P I+SP  P  T    P+  P+ P+
Sbjct: 530 PTIASPPPPLPTTTPPPQTPPLPPL 554


>gi|104526627 triadin [Homo sapiens]
          Length = 729

 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 73/377 (19%), Positives = 142/377 (37%), Gaps = 31/377 (8%)

Query: 112 RDLHRDQGRRKTQWYKLKSKPGKK-DKERGEIEVDIQFMRNNMTASMFDLSMK-DKSRNP 169
           +D  ++  ++  +  +++   GKK +K+   +E      + +   S   +  K ++++  
Sbjct: 373 KDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEE 432

Query: 170 FG--KLKDKIKGKNKDSGSDTASAIIPSTTPSVDSDDESVVKDKKKKSKIKTLLSKSNLQ 227
            G   +K  + GK ++  + T    I        S   S++KDK+          K   +
Sbjct: 433 IGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTS---SILKDKEP--------IKGKEE 481

Query: 228 KTPLSQSMSVLPTSKPEKVLLRPGDFQSQWDEDDNEDESSSASDVMSHKRTASTDLKQLN 287
           K P S       T K EK+     + + +  +   + E      +    + A ++  Q++
Sbjct: 482 KVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIH 541

Query: 288 QVNFTLPKKEGLSFLGGLRSKNDVLSRSNVCINGNHVYLEQPEAKGEIKDSSPSS----- 342
           + +   P+K     +   + +  VL +    +        +P  K E ++  P S     
Sbjct: 542 KQDIVKPEKT----VSHGKPEEKVLKQVKA-VTIEKTAKPKPTKKAEHREREPPSIKTDK 596

Query: 343 -SPSPKGFRKKHLFSSTENLAAGSWKEPAEGGGLSSDRQLSESSTKDSLKSMTLPSYRPA 401
             P+PKG     +  S +     S KE  E   +   R+   S+ K+SL+   +      
Sbjct: 597 PKPTPKG--TSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKP 654

Query: 402 PLVSGDLRENMAPANSEATKEAKESKKPESRRSSLLSLMTGKKDVAKGSEGENPLTVPGR 461
             VS D+ +   PA+ +A KE  E   P  ++S +        D   G   + P T   R
Sbjct: 655 ARVSKDVED--VPASKKA-KEGTEDVSPTKQKSPISFFQCVYLDGYNGYGFQFPFTPADR 711

Query: 462 EKEGMLMGVKPGEDASG 478
             E       PG+   G
Sbjct: 712 PGESSGQANSPGQKQQG 728



 Score = 29.6 bits (65), Expect = 9.1
 Identities = 62/329 (18%), Positives = 113/329 (34%), Gaps = 64/329 (19%)

Query: 327 EQPEAKGEIKDS-SPSSSPSPKGFRKKHLFSSTENLAAGSWKEPAEGGGLSSDRQLSESS 385
           E+PE K   K+       P  K   K+   + T   +    K+  +GG     +Q + + 
Sbjct: 178 EKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTA-AK 236

Query: 386 TKDSLKSMTLPS-----------------------YRPAPLVSGDLRENMAPANSEATKE 422
            K+  K+ + P                        Y     V GDL+   +PA       
Sbjct: 237 VKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPT 296

Query: 423 AKESKKPESRRSSLLSLMTGKKDVAKGSEGENPLTVPGREKEGMLMGVKPGEDASGPAED 482
            + S+   +  S  L    G+K  A     E  +T   ++KE                ED
Sbjct: 297 EQASRPTPA--SPALEEKEGEKKKA-----EKKVTSETKKKE---------------KED 334

Query: 483 LVRRSEKDTAAVVSR---------QGSSLNLFEDVQITEPEAEPESKSEPRP-PISSPRA 532
           + ++SEK+TA  V +         +  ++ +       + E + +SK   +P  +  P+ 
Sbjct: 335 IKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKG 394

Query: 533 PQTRAVKPRLHPVKPMNATATKVANCSLGTATIISENLNNEVMMKKYSPSDPAFAYAQLT 592
            +    +  + P K      +  ++  +   T  ++     V +KK  P        +  
Sbjct: 395 KKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTV 454

Query: 593 HDEL-------IQLVLKQKETISKKEFQV 614
             E+          +LK KE I  KE +V
Sbjct: 455 EQEIRKEKSGKTSSILKDKEPIKGKEEKV 483


>gi|56550039 myeloid/lymphoid or mixed-lineage leukemia protein [Homo
            sapiens]
          Length = 3969

 Score = 42.0 bits (97), Expect = 0.002
 Identities = 96/433 (22%), Positives = 169/433 (39%), Gaps = 63/433 (14%)

Query: 186  SDTASAIIPSTTPSVDSDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPTSKPEK 245
            S  +S+ +  +T S+ S      K      ++ +LL K+  Q   + +S S+  T +P+ 
Sbjct: 992  STPSSSTVKHSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQLCKIEKSKSLKQTDQPK- 1050

Query: 246  VLLRPGDFQSQWDEDDNEDESSSASDVMSHKRTASTDLKQLNQVN-------FTLPKKEG 298
                     +Q  E D+ + S     +    R A+  L +   V          LP +E 
Sbjct: 1051 ---------AQGQESDSSETSVRGPRIKHVCRRAAVALGRKRAVFPDDMPTLSALPWEER 1101

Query: 299  LSFLGGLRSKNDVLSRSNVCINGNHVYLEQP--EAKGEIKDSSPSSSPSPKGFRKKHLFS 356
               L  + + +    +S++  + +   L  P    K   ++ +P   P  KG R +    
Sbjct: 1102 EKILSSMGNDD----KSSIAGSEDAEPLAPPIKPIKPVTRNKAPQEPPVKKGRRSRRCGQ 1157

Query: 357  STE-------NLAAGSWKEPAEGGGLSSDRQLSESSTKDSLKSMTLPSYRPAPLVSGDLR 409
                       +      +P + GG +  +Q  +     +L+ M   +Y           
Sbjct: 1158 CPGCQVPEDCGVCTNCLDKP-KFGGRNIKKQCCKMRKCQNLQWMPSKAYL---------- 1206

Query: 410  ENMAPANSEATKEAKESKKPESRRSSLLSLM---------TGKKDVA-KGSEGENPLTVP 459
            +  A A  +  K++K S+K +S+ SS++  +         + ++D A K S  E P   P
Sbjct: 1207 QKQAKAVKKKEKKSKTSEKKDSKESSVVKNVVDSSQKPTPSAREDPAPKKSSSEPPPRKP 1266

Query: 460  GREK--EGMLMGVKP-GEDASGPAEDLVRRSEKDTAAVVSRQGSSLNL-FEDVQITEPEA 515
              EK  EG +    P  + A+ PA     +     A V+  Q  +     ++V  T P +
Sbjct: 1267 VEEKSEEGNVSAPGPESKQATTPASRKSSKQVSQPALVIPPQPPTTGPPRKEVPKTTP-S 1325

Query: 516  EPESKSEPRPPISSPRAPQTRAVKPRLH-PVKPMNATATKVANC----SLGTATIISENL 570
            EP+ K +P PP S P   + + V PR   PVK       K        + GT  I+S  L
Sbjct: 1326 EPKKK-QPPPPESGPEQSKQKKVAPRPSIPVKQKPKEKEKPPPVNKQENAGTLNILS-TL 1383

Query: 571  NNEVMMKKYSPSD 583
            +N    K+  P+D
Sbjct: 1384 SNGNSSKQKIPAD 1396



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 47/208 (22%), Positives = 73/208 (35%), Gaps = 28/208 (13%)

Query: 366 WKEPAE----GGGLSSDRQLSESSTKDSLKSMTLPSYRPAPLVSGDL--RENMAPANSEA 419
           W+ PA     GGG    R+    + +  + ++ LP   P P V G         PA + A
Sbjct: 7   WRFPARPGTTGGGGGGGRRGLGGAPRQRVPALLLP---PGPPVGGGGPGAPPSPPAVAAA 63

Query: 420 TKEAKESKKPESRRSSLLSLMTGKKDVAKGSEGENPLTVPGREKEGMLMGVKPGEDASGP 479
              A  S       ++  S  +     +  S   +  + P       L+ V PG DA+  
Sbjct: 64  AAAAGSSGAGVPGGAAAASAASSSSASSSSSSSSSASSGPA------LLRVGPGFDAALQ 117

Query: 480 AEDLVRRSEKDTAAVVSRQGSSLNLFED-----------VQITEPEAEPESKSEPRPPIS 528
               +  + +   AV    G      ED           V++  P   P  K+ PR P  
Sbjct: 118 VSAAIGTNLRRFRAVFGESGGGGGSGEDEQFLGFGSDEEVRVRSPTRSPSVKTSPRKPRG 177

Query: 529 SPRAPQTR--AVKPRLHPVKPMNATATK 554
            PR+   R  A+        P+N + TK
Sbjct: 178 RPRSGSDRNSAILSDPSVFSPLNKSETK 205



 Score = 32.0 bits (71), Expect = 1.8
 Identities = 69/325 (21%), Positives = 122/325 (37%), Gaps = 42/325 (12%)

Query: 268  SASDVMSHKRTAS-TDLKQLNQV-NFTLPKKEGLSFLGGLRSKNDVLSRSNVCINGNHVY 325
            S ++V S   T + TDL+   +V +  L      + LG   S +  L R+ V +   + +
Sbjct: 2220 SRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSH 2279

Query: 326  LEQPEAKGEIKDSSPSS----SPSPKGFRKKHLFSSTENLAAGSWKEPAEGGGLSSDRQL 381
            L+   +  E+K SS S     S S KG + K L S +   +A +   P    G+      
Sbjct: 2280 LDG-SSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYP----GIPKLAPQ 2334

Query: 382  SESSTKDSLKSMTLPSYRPAPLVSGDLRE-------------NMAPANSEATKEAKESKK 428
              ++T   L    + S+     VS   +E             N    ++++T+ A  S  
Sbjct: 2335 VHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPD 2394

Query: 429  PE-----------SRRSSLLSLMTGKKDVAKGSEGENPLTVPGREKEGMLMGVKPGEDAS 477
             +           S RSS+++   G     +  +G+       +EK      ++PG+  +
Sbjct: 2395 EDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTT 2454

Query: 478  GPAEDLVRRSEKDTAAVVSRQGS------SLNLFEDVQITEPEAEPESKSEPRPPISSPR 531
            G   +L +    D        G       S +   D  ++ P        +        +
Sbjct: 2455 GEEGNL-KPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQ 2513

Query: 532  APQTRAVKPRLHPVKPMNATATKVA 556
            AP+ R VK  L P+K  N + +K A
Sbjct: 2514 APRKRTVKVTLTPLKMENESQSKNA 2538


>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
          Length = 2454

 Score = 41.6 bits (96), Expect = 0.002
 Identities = 88/403 (21%), Positives = 147/403 (36%), Gaps = 87/403 (21%)

Query: 129  KSKPGKKDKERGEIEVDIQFMRNNMTASMFDL---SMKDKSRNPFGKLKDKIK-GKNKDS 184
            KSK G   +E+   ++  +  R     S  D    SMK+   N   K   +I+  + ++ 
Sbjct: 1043 KSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNL 1102

Query: 185  GSDTASAIIPSTTPSVDSDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPTSKPE 244
             S   +  I S + S D+++ S  +D KKK +  +   K+ + K     S   L TS   
Sbjct: 1103 SSKRNTKEIQSGSSSSDAEESS--EDNKKKKQRTSSKKKAVIVKEKKRNS---LRTSTKR 1157

Query: 245  KVLLRPGDFQSQWDEDDNEDESSSASDVMSHKRTASTDLKQLNQVNFTLPKKEGLSFLGG 304
            K      D  S    D  +D+ +S  +        S+D +++  V   L       F   
Sbjct: 1158 K----QADITSSSSSDIEDDDQNSIGE-------GSSDEQKIKPVTENLVLSSHTGFCQS 1206

Query: 305  LRSKNDVLSRSNVCINGNHVYLEQPEAKGEIKDSSPSSSPSPKGFRKKHLFSSTENLAA- 363
              S ++ LS+S                   + D    + P  +  +K  L     NL++ 
Sbjct: 1207 --SGDEALSKS---------------VPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSD 1249

Query: 364  --GSWKEPAEGGGLSSDRQLSESSTKDSLKSMTLPSYRPAPLVSGDLRENMAPANSEATK 421
              GS  +  E G   + +Q  E+   +  K+                       NSE+  
Sbjct: 1250 EDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQV---------------------NSESDS 1288

Query: 422  EAKESKKPESRRSSLLSLMTGKKDVAKGSEGENPLTVPGREKEGMLMGVKPGEDASGPAE 481
            +++ESKKP  R      L+  K  V+ G  GE   T P   KE                +
Sbjct: 1289 DSEESKKPRYRH----RLLRHKLTVSDGESGEEKKTKPKEHKE---------------VK 1329

Query: 482  DLVRRSEKDTAAVVSRQGSSLNLFEDVQITEPEAEPESKSEPR 524
               RR        VS + S  + F++  ++E  +E E +  PR
Sbjct: 1330 GRNRRK-------VSSEDSEDSDFQESGVSEEVSESEDEQRPR 1365



 Score = 31.2 bits (69), Expect = 3.1
 Identities = 27/102 (26%), Positives = 47/102 (46%), Gaps = 11/102 (10%)

Query: 196 TTPSVDSDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPTSKPEKVLLRPGDFQS 255
           T P   + DE   +  K+K K+   + K    K   + S S +   KP K+   P   QS
Sbjct: 632 TNPVTSNSDEECNETVKEKQKLSVPVRK----KDKRNSSDSAIDNPKPNKL---PKSKQS 684

Query: 256 QW-DEDDNEDESSS---ASDVMSHKRTASTDLKQLNQVNFTL 293
           +  D++ + DE  +       MSH  ++ TD+ +++  + TL
Sbjct: 685 ETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTL 726


>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
          Length = 2492

 Score = 41.6 bits (96), Expect = 0.002
 Identities = 88/403 (21%), Positives = 147/403 (36%), Gaps = 87/403 (21%)

Query: 129  KSKPGKKDKERGEIEVDIQFMRNNMTASMFDL---SMKDKSRNPFGKLKDKIK-GKNKDS 184
            KSK G   +E+   ++  +  R     S  D    SMK+   N   K   +I+  + ++ 
Sbjct: 1081 KSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNL 1140

Query: 185  GSDTASAIIPSTTPSVDSDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPTSKPE 244
             S   +  I S + S D+++ S  +D KKK +  +   K+ + K     S   L TS   
Sbjct: 1141 SSKRNTKEIQSGSSSSDAEESS--EDNKKKKQRTSSKKKAVIVKEKKRNS---LRTSTKR 1195

Query: 245  KVLLRPGDFQSQWDEDDNEDESSSASDVMSHKRTASTDLKQLNQVNFTLPKKEGLSFLGG 304
            K      D  S    D  +D+ +S  +        S+D +++  V   L       F   
Sbjct: 1196 K----QADITSSSSSDIEDDDQNSIGE-------GSSDEQKIKPVTENLVLSSHTGFCQS 1244

Query: 305  LRSKNDVLSRSNVCINGNHVYLEQPEAKGEIKDSSPSSSPSPKGFRKKHLFSSTENLAA- 363
              S ++ LS+S                   + D    + P  +  +K  L     NL++ 
Sbjct: 1245 --SGDEALSKS---------------VPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSD 1287

Query: 364  --GSWKEPAEGGGLSSDRQLSESSTKDSLKSMTLPSYRPAPLVSGDLRENMAPANSEATK 421
              GS  +  E G   + +Q  E+   +  K+                       NSE+  
Sbjct: 1288 EDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQV---------------------NSESDS 1326

Query: 422  EAKESKKPESRRSSLLSLMTGKKDVAKGSEGENPLTVPGREKEGMLMGVKPGEDASGPAE 481
            +++ESKKP  R      L+  K  V+ G  GE   T P   KE                +
Sbjct: 1327 DSEESKKPRYRH----RLLRHKLTVSDGESGEEKKTKPKEHKE---------------VK 1367

Query: 482  DLVRRSEKDTAAVVSRQGSSLNLFEDVQITEPEAEPESKSEPR 524
               RR        VS + S  + F++  ++E  +E E +  PR
Sbjct: 1368 GRNRRK-------VSSEDSEDSDFQESGVSEEVSESEDEQRPR 1403



 Score = 31.2 bits (69), Expect = 3.1
 Identities = 27/102 (26%), Positives = 47/102 (46%), Gaps = 11/102 (10%)

Query: 196 TTPSVDSDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPTSKPEKVLLRPGDFQS 255
           T P   + DE   +  K+K K+   + K    K   + S S +   KP K+   P   QS
Sbjct: 670 TNPVTSNSDEECNETVKEKQKLSVPVRK----KDKRNSSDSAIDNPKPNKL---PKSKQS 722

Query: 256 QW-DEDDNEDESSS---ASDVMSHKRTASTDLKQLNQVNFTL 293
           +  D++ + DE  +       MSH  ++ TD+ +++  + TL
Sbjct: 723 ETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTL 764


>gi|239741684 PREDICTED: ankyrin repeat domain 36 [Homo sapiens]
          Length = 1524

 Score = 41.2 bits (95), Expect = 0.003
 Identities = 96/468 (20%), Positives = 156/468 (33%), Gaps = 77/468 (16%)

Query: 161 SMKDKSRNPFGKLK------DKIKGKNKDSGSDTASAI----IPSTTPSVDSDDESVVKD 210
           +M+ K   P GK+       +K    +KDS S+ A+ I    I  T  S     E    D
Sbjct: 252 AMRRKDSPPPGKVSSQKQPAEKATSDDKDSVSNIATEIKEGPISGTVSSQKQPAEKATSD 311

Query: 211 KKKK-SKIKTLLSKSNLQKTPLSQSMSVLPTSKPEKVLLRP------GDFQSQWDEDDNE 263
           +K   S I T + K     T   Q  S       +KV L        G  +S       +
Sbjct: 312 EKDSVSNIATEIKKGQQSGTVSPQKQSAWKVIFKKKVSLLNIATRIMGGGKSGTVSSQKQ 371

Query: 264 DESSSASDVMSHKRTASTDLKQLNQVNFTLPKKEGLSFLGGLRSKNDVLSRSNVCINGNH 323
             S + SD        +T++K   Q      +K+    L     + D  S SN+      
Sbjct: 372 PASKATSDKTDSALNIATEIKDGLQCGTVSSQKQPA--LKATTDEED--SVSNIAT---- 423

Query: 324 VYLEQPEAKGEIKDSSPSSSPSPKGFRKKHLFSSTENLAAGSWKEPAEGGGLSSDRQLSE 383
                     EIKD   S + S                   S K+PA          +S 
Sbjct: 424 ----------EIKDGEKSGTVS-------------------SQKQPALKATTDEKDSVSN 454

Query: 384 SST--KDSLKSMTLPSYRPAPLVSGDLRENMAPANSEATKEAKESKKPESRRSSLLSLMT 441
            +T  KD  KS T+ S +P  L +    E    + +   K+ ++S+   SR+   L   +
Sbjct: 455 IATEIKDGEKSGTVSSQKPPALTATSDEEGSVLSIARENKDGEKSRTVSSRKKPALKATS 514

Query: 442 GKKD----VAKGSEGENPLTVPGREKEGMLMGVKPGEDASGPAEDLVRRSEKDTAAVVSR 497
            +KD    + +G +          +K   L G                  E+D+   ++R
Sbjct: 515 DEKDSFSNITRGKKDGEISRKVSSQKPPTLKGTS---------------DEEDSVLGIAR 559

Query: 498 QGSSLNLFEDVQITEPEAEPESKSEPRPPISSPRAPQTRAVKPRLHPVKPMNATATKVAN 557
           +         V   +P     S +E    ++  R  +      R+   K  +  AT    
Sbjct: 560 ENKDGEKSRTVSSEKPPGLKASSAEKDSVLNIARGKKDGEKTKRVSSRKKPSLEATSDEK 619

Query: 558 CSLGTATIISENLNNEVMMKKYSPSDPAFAYAQLTHDELIQLVLKQKE 605
            S   + I  E  + E+  K  S   PA        D ++ +  + K+
Sbjct: 620 DSF--SNITREKKDGEISRKVSSQKPPALKGTSDEEDSVLGIARENKD 665


>gi|50083281 KIAA1853 protein [Homo sapiens]
          Length = 611

 Score = 41.2 bits (95), Expect = 0.003
 Identities = 66/314 (21%), Positives = 108/314 (34%), Gaps = 46/314 (14%)

Query: 166 SRNPFGKLKDKIKGKNKDSGSDTASAIIPSTTPSVDSDDESVVKDKKKKSKIKTLLSKSN 225
           S +P  K K K   K+K   S +      S++P     DE     K+ K + ++   KS+
Sbjct: 127 SPSPVKKKKKKSSKKHKRRRSFSKKRRHSSSSPKSKRRDE-----KRHKKQSRSRPRKSH 181

Query: 226 LQKTPLSQSMSVLPTSKPEKVLLRPGDFQSQWDEDDNEDESSSASDVMSHKRTASTDLKQ 285
             +     S S    S+P     R               E    S     +R + T  K 
Sbjct: 182 RHRHHRCPSRSQSSESRPSSCESR---------HRGRSPEEGQKSRRRHSRRCSKTLCKD 232

Query: 286 LNQVNFTLPKKEGLSFLGGLRSKNDVLSRSNVC--INGNHVYLEQPEAKGEIKDSSPSSS 343
             +   + P  + L  LG L ++  +    +           L     + +  DS   +S
Sbjct: 233 SPEAQSSRPPSQPLQMLGYLSARGVITGSGSAADLFTKTASPLTTSRGRSQEYDSGNDTS 292

Query: 344 PSPKGFRKKHLFSSTENLAAGSWKEPAEGGGLSSDRQLSESSTKDSLKSMTLPSYRPAPL 403
             P         + T +  +   ++ +  GGLS  R+L+  +T DS  S T  S    P 
Sbjct: 293 SPPS--------TQTSSARSRGQEKGSPSGGLSKSRELNSGNTSDSGNSFTTSS----PQ 340

Query: 404 VSGDLRENMAPANS------------EATKEAKESKKPESRRSSLL------SLMTGKKD 445
             G + EN++P +             E  +  K S  P + RSS +      S     + 
Sbjct: 341 NKGAMLENLSPTSRGRESRGFQSPCLECAEVKKSSLVPSTARSSPMKGCSRSSSYASTRS 400

Query: 446 VAKGSEGENPLTVP 459
            +  S   NP   P
Sbjct: 401 SSHSSRSPNPRASP 414


>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
          Length = 2752

 Score = 41.2 bits (95), Expect = 0.003
 Identities = 56/235 (23%), Positives = 87/235 (37%), Gaps = 25/235 (10%)

Query: 327 EQPEAKGEIKDSSPSSSPSPKGFRKKHLFSSTENLAAGSWKEPAEGGGLSSDRQLSESST 386
           E P+    +++SS S SP+PK  +KK          + S +   +        +    S 
Sbjct: 166 EPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESK 225

Query: 387 KDSLKSMTLPSYRPAPLVSGDLRENMAPANSEATKEAKESKKPESRRSSLLSLMTGKKDV 446
           K   +S T  S R +         +  PA    ++ A  S   +S  SS  S    +   
Sbjct: 226 KRKHRSPTPKSKRKSKDKKRKRSRSTTPA--PKSRRAHRSTSADSASSSDTSRSRSRSAA 283

Query: 447 AK----GSEGENPLTVPGREKEGMLMGVKPGEDASGPAEDLVRRSEKDTAAVVSRQGSSL 502
           AK       G +P    GR  EG     +PG  ++       R S  +TA   ++Q SS 
Sbjct: 284 AKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTST------QRPSSPETA---TKQPSS- 333

Query: 503 NLFED-------VQITEPEAEPE-SKSEPRPPISSPRAPQTRAVKPRLHPVKPMN 549
             +ED          T P   PE S + P PP  +P   +     P+     P++
Sbjct: 334 -PYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLS 387



 Score = 36.2 bits (82), Expect = 0.097
 Identities = 42/202 (20%), Positives = 71/202 (35%), Gaps = 13/202 (6%)

Query: 327  EQPEAKGEIKDSSPSSSPSPKGFRKKHLFSSTENLAAGSWKEPAEGGGLSSDRQLSESST 386
            +QP A   ++ +    S S          SS+ + ++ S    +  G  SSD + S    
Sbjct: 2516 QQPSALAALQPAKERRSSSSSSSS-----SSSSSSSSSSSSSSSSSGSSSSDSEGSSLPV 2570

Query: 387  KDSLKSMTLPSYRPAPLVSGDLRENMAPANSEATKEAKESKKPESRRSSLLSLMTGKKDV 446
            +  +    +PS  PAP     +RE   P  + A ++ + S    S  SS  S  +     
Sbjct: 2571 QPEVALKRVPSPTPAP--KEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSS 2628

Query: 447  AKGSEGENPLTVPGREKEGMLMGVKPGEDA-SGPAEDL-----VRRSEKDTAAVVSRQGS 500
            +  S   +  +             KPG  A   PA         RRS      + S + S
Sbjct: 2629 SSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDS 2688

Query: 501  SLNLFEDVQITEPEAEPESKSE 522
                +  V+   P  +P  + +
Sbjct: 2689 RSLSYSPVERRRPSPQPSPRDQ 2710



 Score = 34.7 bits (78), Expect = 0.28
 Identities = 120/602 (19%), Positives = 218/602 (36%), Gaps = 85/602 (14%)

Query: 16   SPTHVQVTVL-QARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERSLGAPVWREEATFEL 74
            SP H   T   + R   ++ P   S +    + G+ + ++ V+E +  +P+ ++   F  
Sbjct: 1064 SPDHRSDTSSPEVRQSHSESPSLQSKSQTSPKGGRSRSSSPVTELASRSPIRQDRGEFSA 1123

Query: 75   PSLLSSGPAAAAT-LQLTVLHRALLGLDKFLGRAEVDLRDLHRDQGRRKTQWYKLKSKPG 133
              +L SG +   +  Q        +  +  LG++ ++  +  +++     Q     S P 
Sbjct: 1124 SPMLKSGMSPEQSRFQSDSSSYPTVDSNSLLGQSRLETAE-SKEKMALPPQEDATASPPR 1182

Query: 134  KKDKERGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGKNKDSGSDTASAII 193
            +KDK          F   +   S   L  KD  R P          +   +GS   +   
Sbjct: 1183 QKDKFS-------PFPVQDRPES--SLVFKDTLRTP--------PRERSGAGSSPETKEQ 1225

Query: 194  PSTTPSVDSDDESVVKDKKKKSKIKTLLS--KSNLQKTPLSQSMSVLPTSKPEKVLLRPG 251
             S  P+   D+E +   +K +     +LS   S L++   S   S     +   V L   
Sbjct: 1226 NSALPTSSQDEELMEVVEKSEEPAGQILSHLSSELKEMSTSNFESSPEVEERPAVSLTLD 1285

Query: 252  DFQSQWDEDDNEDESSSAS-----DVMSHKRTASTDLKQLN-----------------QV 289
              QSQ   +  E  S ++S         HK  +++ L++ +                   
Sbjct: 1286 QSQSQASLEAVEVPSMASSWGGPHFSPEHKELSNSPLRENSFGSPLEFRNSGPLGTEMNT 1345

Query: 290  NFTLPKKEGLS--FLGGLRSKNDVLSRSNVCINGNHVYLE-QPEAKGEIKDSSPSSSPSP 346
             F+   KE L+  FL  L +   +  +     +  H   E  P+A  +   SS  S  SP
Sbjct: 1346 GFSSEVKEDLNGPFLNQLETDPSLDMKEQSTRSSGHSSSELSPDAVEKAGMSSNQSISSP 1405

Query: 347  -------KGFRKKHLFSSTENLAAGSWKEPAEGGGLSSDRQLSESSTKDSLKSMTLPSYR 399
                      R++   +S+  +  G  + P+      S   L + S   S  S++  S  
Sbjct: 1406 VLDAVPRTPSRERSSSASSPEMKDGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPG 1465

Query: 400  PAPLVSGDLRENMAPANSEATKEAKESKKPESRRSSLLSL----MTGKKDVAKGSEGE-- 453
               +     R      +S   K   ++ +P SR  S   L    +T +++   GSE    
Sbjct: 1466 MKDIPRTPSRGRSECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRE-RSGSESSVD 1524

Query: 454  ------NPLTVPGREKEGMLMGVKPGEDASGPAEDLVRRSEKDTAAVV-------SRQGS 500
                   PL    R      + VKP   ++ P E     S  D+ A         SR GS
Sbjct: 1525 QKTVARTPLGQRSRSGSSQELDVKP---SASPQERSESDSSPDSKAKTRTPLRQRSRSGS 1581

Query: 501  SLNLFEDVQIT--------EPEAEPESKSEPRPPISSPRAPQTRAVKPRLHPVKPMNATA 552
            S  +    +++         PE + + ++ PR    S  +P+ +A  PR  P +  + ++
Sbjct: 1582 SPEVDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSS 1641

Query: 553  TK 554
            +K
Sbjct: 1642 SK 1643



 Score = 29.6 bits (65), Expect = 9.1
 Identities = 55/237 (23%), Positives = 83/237 (35%), Gaps = 21/237 (8%)

Query: 313 SRSNVCINGNHVYLEQPEAKGEIKDSSPSSSPSPKGFR----------KKHLFSSTENLA 362
           SRS   +     +   P+ +G    SS   + S    R          KK   SS  + +
Sbjct: 702 SRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRS 761

Query: 363 AGSWKEPAEGGGLSSDRQLSESSTKDSLKSMTLPSYRPAPLVSGDLRENMAPANSEATKE 422
             S +  A+   LS  R LS SS     KS T P    +       +    P  S ++  
Sbjct: 762 LSSPRSKAKSR-LSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSS 820

Query: 423 A--KESKKPESRRSSLLSLMTGKKDVAKGSEGENPLTVPGREKEGMLMGVKPGEDASGPA 480
              K+  K  SR+S   S    K  V  G+          +  E  +   +     S P 
Sbjct: 821 PPPKQKSKTPSRQSHSSSSPHPK--VKSGTPPRQGSITSPQANEQSVTPQRRSCFESSPD 878

Query: 481 EDLVRRSEKDTAAVVSRQGSSLNLFEDVQITEPEAEPESKSEPRPPISSPRAPQTRA 537
            +L  R    T +  S  GSS    +    T P   P   S P+P + +  +P+ R+
Sbjct: 879 PELKSR----TPSRHSCSGSSPPRVKSS--TPPRQSPSRSSSPQPKVKAIISPRQRS 929


>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
          Length = 1301

 Score = 40.8 bits (94), Expect = 0.004
 Identities = 61/326 (18%), Positives = 109/326 (33%), Gaps = 14/326 (4%)

Query: 130 SKPGKKDKERGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGKNKDSGSDTA 189
           S   K D  + E +      +++ +    D +  D S N      D     N    SD++
Sbjct: 619 SSDSKSDSSKSESDSSDSDSKSDSS----DSNSSDSSDN--SDSSDSSNSSNSSDSSDSS 672

Query: 190 -SAIIPSTTPSVDSDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPTSKPEKVLL 248
            S+   S++ S +S D S   D    S+       S+   +  S S +   +        
Sbjct: 673 DSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSS 732

Query: 249 RPGDFQSQWDEDDNEDESSSASDVMSHKRTASTDLKQLNQVNFTLPKKEGLSFLGGLRSK 308
              D  +  D  D+ D S+S+    S   + S+D    +  + +                
Sbjct: 733 DSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNS-------SDS 785

Query: 309 NDVLSRSNVCINGNHVYLEQPEAKGEIKDSSPSSSPSPKGFRKKHLFSSTENLAAGSWKE 368
           ND  + S+   + N           +  DSS S S +          S + N +  S   
Sbjct: 786 NDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSS 845

Query: 369 PAEGGGLSSDRQLSESSTKDSLKSMTLPSYRPAPLVSGDLRENMAPANSEATKEAKESKK 428
            +  G  S     S+SS        +  S       S D  E+   ++S  +  + +S  
Sbjct: 846 DSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDS 905

Query: 429 PESRRSSLLSLMTGKKDVAKGSEGEN 454
            +S  SS  S  +   D ++ S   +
Sbjct: 906 SDSSNSSDSSDSSNSSDSSESSNSSD 931



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 73/412 (17%), Positives = 141/412 (34%), Gaps = 18/412 (4%)

Query: 132 PGKKDKERGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGKNKDSGSDTASA 191
           P   D+  G  + + +   +N ++S  D S         G   D    ++ DS S + + 
Sbjct: 465 PNSSDESNGNDDANSE--SDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTN 522

Query: 192 IIPSTTPSVDSDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPTSKPEKVLLRPG 251
              S     + +D++   DK    K K+  S S+   +  S   S    S          
Sbjct: 523 NSDSNGNGNNGNDDN---DKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSS------- 572

Query: 252 DFQSQWDEDDNEDESSSASDVMSHKRTASTDLKQLNQVNFTLPKKEGLSFLGGLRSKNDV 311
           D  S  D D ++ +SS +SD  S   + S+D    +  + +    +              
Sbjct: 573 DSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESD 632

Query: 312 LSRSNVCINGNHVYLEQPEAKGEIKDSSPS--SSPSPKGFRKKHLFSSTENLAAGSWKEP 369
            S S+   + +           +  DSS S  SS S          SS+++  +    + 
Sbjct: 633 SSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDS 692

Query: 370 AEGGGLSSDRQLSESSTKDSLKSMTLPSYRPAPLVSGDLRENMAPANSEATKEAKESK-- 427
           ++    S     S+SS  DS  S    +   +   S +  ++   +NS  + ++ +S   
Sbjct: 693 SDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNS 752

Query: 428 --KPESRRSSLLSLMTGKKDVAKGSEGENPLTVPGREKEGMLMGVKPGEDASGPAEDLVR 485
               +S  SS  S  +   D +  S+  N                    D+S  ++    
Sbjct: 753 SDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDS 812

Query: 486 RSEKDTAAVVSRQGSSLNLFEDVQITEPEAEPESKSEPRPPISSPRAPQTRA 537
               D+ +  S   S+ +   D   +   ++    S+     SS R+  + +
Sbjct: 813 SDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNS 864



 Score = 32.3 bits (72), Expect = 1.4
 Identities = 58/281 (20%), Positives = 91/281 (32%), Gaps = 21/281 (7%)

Query: 175  DKIKGKNKDSGSDTASAIIPSTTPSVDSDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQS 234
            D     +  + SD++ +   S + S +S D S   D    S        S+      S S
Sbjct: 796  DSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDS 855

Query: 235  MSVLPTSKPEKVLLRPGDFQSQWDEDDNEDESSSASDVMSHKRTASTDLKQLNQVNFTLP 294
             +   +S          D     D  ++ D S S+    S   + S+D    N  +    
Sbjct: 856  SNRSDSSNSS-------DSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSS--NSSDSDSS 906

Query: 295  KKEGLSFLGGLRSKNDVLSRSNVCINGNHVYLEQPEAKGEIKDSSPSSSPSPKGFRKKHL 354
                 S      + +D    SN   N N           +  DSS SS  S         
Sbjct: 907  DSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSS 966

Query: 355  FSSTENLAAGSWKEPAEGGGLSSDRQLSESSTKDSLKSMTLPSYRPAPLVSGDLRENMAP 414
             SS  N +  S    +     SSD   S  S+  S  S            S D  ++   
Sbjct: 967  DSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSS-----------DSSDSSDSSDS 1015

Query: 415  AN-SEATKEAKESKKPESRRSSLLSLMTGKKDVAKGSEGEN 454
            +N S+++  +  S   +S  SS  S  +   D +  S+  N
Sbjct: 1016 SNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSN 1056



 Score = 32.0 bits (71), Expect = 1.8
 Identities = 48/210 (22%), Positives = 81/210 (38%), Gaps = 27/210 (12%)

Query: 251 GDFQSQWDEDDNEDESSSASDVMSHKRTASTDLKQLNQVNFTLPKKEGLSFLGGLRSKND 310
           GD  +  DE +  D+++S SD  S  R  ++     ++ N       G    G     +D
Sbjct: 462 GDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDN-----GNGSDSKGAEDDDSD 516

Query: 311 VLSRSNVC------INGNHVYLEQPEAKGEIKDSSPSSSPSPKGFRKKHLFSSTENLAAG 364
             S +N         NGN    +    KG+  DSS S S            SS  + ++ 
Sbjct: 517 STSDTNNSDSNGNGNNGNDDNDKSDSGKGK-SDSSDSDSSD----------SSNSSDSSD 565

Query: 365 SWKEPAEGGGLSSDRQLSESSTKDSLKSMTLPSYRPAPLVSGDLRENMAPANSEATKEAK 424
           S    +     SSD   S+S + DS  S +  S       S D  ++   ++S  + ++ 
Sbjct: 566 SSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSN-----SSDSSDSSDSSDSSDSSDSS 620

Query: 425 ESKKPESRRSSLLSLMTGKKDVAKGSEGEN 454
           +SK   S+  S  S    K D +  +  ++
Sbjct: 621 DSKSDSSKSESDSSDSDSKSDSSDSNSSDS 650


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.308    0.126    0.345 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,730,470
Number of Sequences: 37866
Number of extensions: 1251056
Number of successful extensions: 6530
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 63
Number of HSP's successfully gapped in prelim test: 299
Number of HSP's that attempted gapping in prelim test: 5889
Number of HSP's gapped (non-prelim): 894
length of query: 649
length of database: 18,247,518
effective HSP length: 109
effective length of query: 540
effective length of database: 14,120,124
effective search space: 7624866960
effective search space used: 7624866960
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.