Guide to the Human Genome
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Name: IRS1 Sequence: fasta or formatted (1242aa) NCBI GI: 5031805
Description:

insulin receptor substrate 1

Referenced in:

Bromodomain Family
Pancreas and Insulin

Composition:

amino acid map
 Amino acid        Percentage    Count  Longest homopolymer
 A alanine             8.0         99           3
 C cysteine            1.7         21           1
 D aspartate           3.9         49           2
 E glutamate           5.2         64           3
 F phenylalanine       2.3         28           3
 G glycine            10.4        129           5
 H histidine           3.8         47           2
 I isoleucine          2.3         28           2
 K lysine              3.3         41           2
 L leucine             6.3         78           2
 M methionine          2.6         32           3
 N asparagine          2.8         35           2
 P proline            10.1        126           7
 Q glutamine           3.5         44           6
 R arginine            6.9         86           3
 S serine             14.7        182           7
 T threonine           4.8         60           1
 V valine              4.3         54           2
 W tryptophan          0.6          7           1
 Y tyrosine            2.6         32           2
Comparative genomics:

Search single species RefSeq proteins at NCBI
   H. sapiens
   M. musculus
   D. rerio
   C. intestinalis
   S. purpuratus
   D. melanogaster
   C. elegans
   A. thaliana
   S. cerevisiae
   E. coli W3110
   A. pernix K1

Search summary

comparative genomics plot

   Figure data

Additional searches of
RefSeq proteins at NCBI

   All
   Eukaryotes
   Bacteria
   Archaea
   Viruses
   Primates
   Mammals
   Vertebrates

Related human proteins:
Protein          Relative score         Description

Self-match            1.000   insulin receptor substrate 1 
IRS2                  0.264   insulin receptor substrate 2 
IRS4                  0.116   insulin receptor substrate 4 
ATN1                  0.016   atrophin-1 
ATN1                  0.016   atrophin-1 
MUC12                 0.014   PREDICTED: mucin 12 
MUC12                 0.013   PREDICTED: mucin 12, cell surface associated 
TCF3                  0.012   transcription factor 3 isoform E47 
TCF3                  0.012   transcription factor 3 isoform E12 
SRRM2                 0.011   splicing coactivator subunit SRm300 
GAB2                  0.010   GRB2-associated binding protein 2 isoform a 
TNRC18                0.010   trinucleotide repeat containing 18 
DOK4                  0.010   docking protein 4 
SCAF1                 0.010   SR-related CTD-associated factor 1 
LOC100130716          0.010   PREDICTED: similar to mucin 11 
FLJ37078              0.010   hypothetical protein LOC222183 
NACA                  0.010   nascent polypeptide-associated complex alpha subuni...
LOC100130716          0.010   PREDICTED: similar to Mucin-12 
MED1                  0.009   mediator complex subunit 1 
FNDC1                 0.009   fibronectin type III domain containing 1 
GAB1                  0.009   GRB2-associated binding protein 1 isoform b 
GAB1                  0.009   GRB2-associated binding protein 1 isoform a 
POLR2A                0.009   DNA-directed RNA polymerase II A 
LOC100133756          0.009   PREDICTED: hypothetical protein, partial 
TSC22D2               0.009   TSC22 domain family, member 2 
GAB4                  0.008   GRB2-associated binding protein family, member 4 [Ho...
GAB3                  0.008   Gab3 protein isoform 1 
HOXA10                0.008   homeobox A10 isoform a 
GAB3                  0.008   Gab3 protein isoform 2 
NHSL1                 0.008   NHS-like 1 
Human BLASTP results (used to prepare the table)

Gene descriptions are from NCBI RefSeq. Search results were obtained with NCBI BLAST and RefSeq entries. When identical proteins are present, the self-match may not be listed first in BLASTP output. In such cases, the table above has been reordered to place it first.

See About the Figures for the scoring system used in the figure above right. The same scoring system was used in the table of BLASTP results.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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