Search of human proteins with 4885433

Search of human proteins with 4885433

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4885433 mitogen-activated protein kinase 8 interacting
protein 1 [Homo sapiens]
         (711 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4885433 mitogen-activated protein kinase 8 interacting protei...  1465   0.0  
gi|239740950 PREDICTED: similar to mitogen-activated protein kin...   643   0.0  
gi|169211037 PREDICTED: similar to mitogen-activated protein kin...   628   e-180
gi|6912492 mitogen-activated protein kinase 8 interacting protei...   414   e-115
gi|7706537 mitogen-activated protein kinase 8 interacting protei...   414   e-115
gi|7705318 GULP, engulfment adaptor PTB domain containing 1 [Hom...    69   2e-11
gi|19924099 synapsin I isoform Ia [Homo sapiens]                       66   1e-10
gi|19924097 synapsin I isoform Ib [Homo sapiens]                       59   2e-08
gi|116284398 WAS/WASL interacting protein family, member 1 [Homo...    55   3e-07
gi|38373695 WAS/WASL interacting protein family, member 1 [Homo ...    55   3e-07
gi|149158690 HLA-B associated transcript-2 [Homo sapiens]              51   4e-06
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]         51   4e-06
gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens]         50   6e-06
gi|130502140 NEZHA isoform 2 [Homo sapiens]                            50   9e-06
gi|122937255 NEZHA isoform 1 [Homo sapiens]                            50   9e-06
gi|5032069 splicing factor 3b, subunit 4 [Homo sapiens]                47   6e-05
gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens]        47   6e-05
gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Hom...    47   8e-05
gi|112734870 hypothetical protein LOC57648 [Homo sapiens]              45   2e-04
gi|178557734 microtubule-associated protein tau isoform 6 [Homo ...    45   2e-04
gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax ...    45   2e-04
gi|50511945 cajalin 2 isoform a [Homo sapiens]                         45   2e-04
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    45   3e-04
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]        45   3e-04
gi|237757326 synaptojanin 1 isoform d [Homo sapiens]                   44   4e-04
gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo ...    44   4e-04
gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo s...    44   4e-04
gi|194473700 Src homology 3 domain-containing guanine nucleotide...    44   4e-04
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    44   5e-04
gi|67514036 SH3-domain kinase binding protein 1 isoform b [Homo ...    44   5e-04

>gi|4885433 mitogen-activated protein kinase 8 interacting protein 1
           [Homo sapiens]
          Length = 711

 Score = 1465 bits (3793), Expect = 0.0
 Identities = 711/711 (100%), Positives = 711/711 (100%)

Query: 1   MAERESGGLGGGAASPPAASPFLGLHIASPPNFRLTHDISLEEFEDEDLSEITDECGISL 60
           MAERESGGLGGGAASPPAASPFLGLHIASPPNFRLTHDISLEEFEDEDLSEITDECGISL
Sbjct: 1   MAERESGGLGGGAASPPAASPFLGLHIASPPNFRLTHDISLEEFEDEDLSEITDECGISL 60

Query: 61  QCKDTLSLRPPRAGLLSAGGGGAGSRLQAEMLQMDLIDATGDTPGAEDDEEDDDEERAAR 120
           QCKDTLSLRPPRAGLLSAGGGGAGSRLQAEMLQMDLIDATGDTPGAEDDEEDDDEERAAR
Sbjct: 61  QCKDTLSLRPPRAGLLSAGGGGAGSRLQAEMLQMDLIDATGDTPGAEDDEEDDDEERAAR 120

Query: 121 RPGAGPPKAESGQEPASRGQGQSQGQSQGPGSGDTYRPKRPTTLNLFPQVPRSQDTLNNN 180
           RPGAGPPKAESGQEPASRGQGQSQGQSQGPGSGDTYRPKRPTTLNLFPQVPRSQDTLNNN
Sbjct: 121 RPGAGPPKAESGQEPASRGQGQSQGQSQGPGSGDTYRPKRPTTLNLFPQVPRSQDTLNNN 180

Query: 181 SLGKKHSWQDRVSRSSSPLKTGEQTPPHEHICLSDELPPQSGPAPTTDRGTSTDSPCRRS 240
           SLGKKHSWQDRVSRSSSPLKTGEQTPPHEHICLSDELPPQSGPAPTTDRGTSTDSPCRRS
Sbjct: 181 SLGKKHSWQDRVSRSSSPLKTGEQTPPHEHICLSDELPPQSGPAPTTDRGTSTDSPCRRS 240

Query: 241 TATQMAPPGGPPAAPPGGRGHSHRDRIHYQADVRLEATEEIYLTPVQRPPDAAEPTSAFL 300
           TATQMAPPGGPPAAPPGGRGHSHRDRIHYQADVRLEATEEIYLTPVQRPPDAAEPTSAFL
Sbjct: 241 TATQMAPPGGPPAAPPGGRGHSHRDRIHYQADVRLEATEEIYLTPVQRPPDAAEPTSAFL 300

Query: 301 PPTESRMSVSSDPDPAAYPSTAGRPHPSISEEEEGFDCLSSPERAEPPGGGWRGSLGEPP 360
           PPTESRMSVSSDPDPAAYPSTAGRPHPSISEEEEGFDCLSSPERAEPPGGGWRGSLGEPP
Sbjct: 301 PPTESRMSVSSDPDPAAYPSTAGRPHPSISEEEEGFDCLSSPERAEPPGGGWRGSLGEPP 360

Query: 361 PPPRASLSSDTSALSYDSVKYTLVVDEHAQLELVSLRPCFGDYSDESDSATVYDNCASVS 420
           PPPRASLSSDTSALSYDSVKYTLVVDEHAQLELVSLRPCFGDYSDESDSATVYDNCASVS
Sbjct: 361 PPPRASLSSDTSALSYDSVKYTLVVDEHAQLELVSLRPCFGDYSDESDSATVYDNCASVS 420

Query: 421 SPYESAIGEEYEEAPRPQPPACLSEDSTPDEPDVHFSKKFLNVFMSGRSRSSSAESFGLF 480
           SPYESAIGEEYEEAPRPQPPACLSEDSTPDEPDVHFSKKFLNVFMSGRSRSSSAESFGLF
Sbjct: 421 SPYESAIGEEYEEAPRPQPPACLSEDSTPDEPDVHFSKKFLNVFMSGRSRSSSAESFGLF 480

Query: 481 SCIINGEEQEQTHRAIFRFVPRHEDELELEVDDPLLVELQAEDYWYEAYNMRTGARGVFP 540
           SCIINGEEQEQTHRAIFRFVPRHEDELELEVDDPLLVELQAEDYWYEAYNMRTGARGVFP
Sbjct: 481 SCIINGEEQEQTHRAIFRFVPRHEDELELEVDDPLLVELQAEDYWYEAYNMRTGARGVFP 540

Query: 541 AYYAIEVTKEPEHMAALAKNSDWVDQFRVKFLGSVQVPYHKGNDVLCAAMQKIATTRRLT 600
           AYYAIEVTKEPEHMAALAKNSDWVDQFRVKFLGSVQVPYHKGNDVLCAAMQKIATTRRLT
Sbjct: 541 AYYAIEVTKEPEHMAALAKNSDWVDQFRVKFLGSVQVPYHKGNDVLCAAMQKIATTRRLT 600

Query: 601 VHFNPPSSCVLEISVRGVKIGVKADDSQEAKGNKCSHFFQLKNISFCGYHPKNNKYFGFI 660
           VHFNPPSSCVLEISVRGVKIGVKADDSQEAKGNKCSHFFQLKNISFCGYHPKNNKYFGFI
Sbjct: 601 VHFNPPSSCVLEISVRGVKIGVKADDSQEAKGNKCSHFFQLKNISFCGYHPKNNKYFGFI 660

Query: 661 TKHPADHRFACHVFVSEDSTKALAESVGRAFQQFYKQFVEYTCPTEDIYLE 711
           TKHPADHRFACHVFVSEDSTKALAESVGRAFQQFYKQFVEYTCPTEDIYLE
Sbjct: 661 TKHPADHRFACHVFVSEDSTKALAESVGRAFQQFYKQFVEYTCPTEDIYLE 711


>gi|239740950 PREDICTED: similar to mitogen-activated protein kinase
           8 interacting protein 1 [Homo sapiens]
          Length = 442

 Score =  643 bits (1658), Expect = 0.0
 Identities = 333/422 (78%), Positives = 345/422 (81%), Gaps = 25/422 (5%)

Query: 312 DPDPAAYPSTAGRPHPSISEEEEGFDCLSSPERAEPPGGGWRGSLGEPPPP------PRA 365
           D + AA    AG P     +E        S  +++ PG G       P  P      P+ 
Sbjct: 24  DEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGPGSG---DTYRPKRPTTLNLFPQV 80

Query: 366 SLSSDTSALSYDSVKY----------------TLVVDEHAQLELVSLRPCFGDYSDESDS 409
            LS DT   +    KY                TL+VDEHAQLELVSLRPCFGDYSDESDS
Sbjct: 81  QLSQDTLNNNSLGKKYKQPRPHHRSRHLHQQPTLLVDEHAQLELVSLRPCFGDYSDESDS 140

Query: 410 ATVYDNCASVSSPYESAIGEEYEEAPRPQPPACLSEDSTPDEPDVHFSKKFLNVFMSGRS 469
           A VYDNC SVSSPYESAIGEEYEEA RPQPPACLS+DSTPDEPDVHFSKKFLN+FMSGRS
Sbjct: 141 AIVYDNCVSVSSPYESAIGEEYEEASRPQPPACLSKDSTPDEPDVHFSKKFLNIFMSGRS 200

Query: 470 RSSSAESFGLFSCIINGEEQEQTHRAIFRFVPRHEDELELEVDDPLLVELQAEDYWYEAY 529
           RSSSAESFGLFSCIIN EEQEQTHR IFRFVPRHEDE ELEVDDPLLVELQAEDYWYEAY
Sbjct: 201 RSSSAESFGLFSCIINREEQEQTHRTIFRFVPRHEDEPELEVDDPLLVELQAEDYWYEAY 260

Query: 530 NMRTGARGVFPAYYAIEVTKEPEHMAALAKNSDWVDQFRVKFLGSVQVPYHKGNDVLCAA 589
           NMRTGARG F AYYAIEVTKEPEHMAALAKNSDWVDQFRVKFLGSVQVPYHKG+ VL AA
Sbjct: 261 NMRTGARGFFTAYYAIEVTKEPEHMAALAKNSDWVDQFRVKFLGSVQVPYHKGDVVLSAA 320

Query: 590 MQKIATTRRLTVHFNPPSSCVLEISVRGVKIGVKADDSQEAKGNKCSHFFQLKNISFCGY 649
           MQKIATTRRLTVHFNPPSSCVLEISVRGVKIGVKADDSQEAKGNKCSHFFQLKNISF GY
Sbjct: 321 MQKIATTRRLTVHFNPPSSCVLEISVRGVKIGVKADDSQEAKGNKCSHFFQLKNISFRGY 380

Query: 650 HPKNNKYFGFITKHPADHRFACHVFVSEDSTKALAESVGRAFQQFYKQFVEYTCPTEDIY 709
           HPKNNKYFGFITKH ADHRFACHVFVSEDSTKALAESVGRAFQQF+KQFVEYTCPTEDIY
Sbjct: 381 HPKNNKYFGFITKHLADHRFACHVFVSEDSTKALAESVGRAFQQFHKQFVEYTCPTEDIY 440

Query: 710 LE 711
           LE
Sbjct: 441 LE 442



 Score =  192 bits (489), Expect = 7e-49
 Identities = 93/96 (96%), Positives = 94/96 (97%)

Query: 91  MLQMDLIDATGDTPGAEDDEEDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGP 150
           MLQMDLIDATGDTPGAEDDEEDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGP
Sbjct: 1   MLQMDLIDATGDTPGAEDDEEDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGP 60

Query: 151 GSGDTYRPKRPTTLNLFPQVPRSQDTLNNNSLGKKH 186
           GSGDTYRPKRPTTLNLFPQV  SQDTLNNNSLGKK+
Sbjct: 61  GSGDTYRPKRPTTLNLFPQVQLSQDTLNNNSLGKKY 96


>gi|169211037 PREDICTED: similar to mitogen-activated protein kinase
           8 interacting protein 1 [Homo sapiens]
          Length = 423

 Score =  628 bits (1620), Expect = e-180
 Identities = 322/406 (79%), Positives = 338/406 (83%), Gaps = 9/406 (2%)

Query: 312 DPDPAAYPSTAGRPHPSISEEEEGFDCLSSPERAEPPGGGWRGSLGEPPPP------PRA 365
           D + AA    AG P     +E        S  +++ PG G       P  P      P+ 
Sbjct: 21  DEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGPGSG---DTYRPKRPTTLNLFPQV 77

Query: 366 SLSSDTSALSYDSVKYTLVVDEHAQLELVSLRPCFGDYSDESDSATVYDNCASVSSPYES 425
            LS DT   +    K   +  +   LELVSLRPCF DYSDESDSA VYDNCASVSSPYES
Sbjct: 78  QLSQDTLNNNSLGKKSRHLHQQPTLLELVSLRPCFRDYSDESDSAIVYDNCASVSSPYES 137

Query: 426 AIGEEYEEAPRPQPPACLSEDSTPDEPDVHFSKKFLNVFMSGRSRSSSAESFGLFSCIIN 485
           AIGEEYEEA RPQPPACLS+DSTPDEPDVHFSKKFLN+FMSGRSRSSSAESFGLFSCIIN
Sbjct: 138 AIGEEYEEASRPQPPACLSKDSTPDEPDVHFSKKFLNIFMSGRSRSSSAESFGLFSCIIN 197

Query: 486 GEEQEQTHRAIFRFVPRHEDELELEVDDPLLVELQAEDYWYEAYNMRTGARGVFPAYYAI 545
            EEQEQTHR IFRFVPRHEDE ELEVDDPLLVELQAEDYWYEAYNMRTGARG+F AYYAI
Sbjct: 198 REEQEQTHRTIFRFVPRHEDEPELEVDDPLLVELQAEDYWYEAYNMRTGARGIFTAYYAI 257

Query: 546 EVTKEPEHMAALAKNSDWVDQFRVKFLGSVQVPYHKGNDVLCAAMQKIATTRRLTVHFNP 605
           EVTKEPEHMAALAKNSDWVDQFRVKFLGSVQVPYHKG+ VL AAMQKIATTRRLTVHFNP
Sbjct: 258 EVTKEPEHMAALAKNSDWVDQFRVKFLGSVQVPYHKGDVVLSAAMQKIATTRRLTVHFNP 317

Query: 606 PSSCVLEISVRGVKIGVKADDSQEAKGNKCSHFFQLKNISFCGYHPKNNKYFGFITKHPA 665
           PSSCVLEISVRGVKIG+KADDSQEAKGNKCSHFFQLKNISF GYHPKNNKYFGFITKH A
Sbjct: 318 PSSCVLEISVRGVKIGIKADDSQEAKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLA 377

Query: 666 DHRFACHVFVSEDSTKALAESVGRAFQQFYKQFVEYTCPTEDIYLE 711
           DHRFACHVFVSEDSTKALAESVGRAFQQF+KQFVEYTCPTE+IYLE
Sbjct: 378 DHRFACHVFVSEDSTKALAESVGRAFQQFHKQFVEYTCPTENIYLE 423



 Score =  180 bits (456), Expect = 5e-45
 Identities = 90/95 (94%), Positives = 90/95 (94%), Gaps = 3/95 (3%)

Query: 91  MLQMDLIDATGDTPGAEDDEEDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGP 150
           MLQMDLIDATGDTPGAE   EDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGP
Sbjct: 1   MLQMDLIDATGDTPGAE---EDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGP 57

Query: 151 GSGDTYRPKRPTTLNLFPQVPRSQDTLNNNSLGKK 185
           GSGDTYRPKRPTTLNLFPQV  SQDTLNNNSLGKK
Sbjct: 58  GSGDTYRPKRPTTLNLFPQVQLSQDTLNNNSLGKK 92


>gi|6912492 mitogen-activated protein kinase 8 interacting protein 2
           isoform 1 [Homo sapiens]
          Length = 824

 Score =  414 bits (1065), Expect = e-115
 Identities = 261/641 (40%), Positives = 343/641 (53%), Gaps = 84/641 (13%)

Query: 122 PGAGPPKAESGQEP-------ASRGQGQSQGQSQGPGSGDTYRPKRPTTLNLFPQVPRSQ 174
           PG   P ++ G E          RG  +S  +   PGS D+          +   +  ++
Sbjct: 217 PGGTSPSSDPGIEADLRSRSSGGRGGRRSSQELSSPGS-DSEDAGGARLGRMISSISETE 275

Query: 175 DTLNNN----SLGKKHSWQDRVSRSSSPLKTGEQTPPHEHICLSDELPP---------QS 221
             L+++    S G+     + +  +SSP    E  PP E       LP          +S
Sbjct: 276 LELSSDGGSSSSGRSSHLTNSIEEASSP--ASEPEPPREPPRRPAFLPVGPDDTNSEYES 333

Query: 222 GPAPTTDRGTSTDSP-------------------CRRSTATQMAPPGGPPAAPPGGRGHS 262
           G     D     DSP                   C     +    P G P +P GG    
Sbjct: 334 GSESEPDLSEDADSPWLLSNLVSRMISEGSSPIRCPGQCLSPAPRPPGEPVSPAGGAAQD 393

Query: 263 HRD--RIHYQADVRLEATEEIYLTPVQRP----PDAAEPTSAFLPPTESRMSVS---SDP 313
            +D         V L   E +   P   P    P  A+P         +R +++   + P
Sbjct: 394 SQDPEAAAGPGGVELVDMETLCAPPPPAPAAPRPGPAQPGPCLFLSNPTRDTITPLWAAP 453

Query: 314 DPAAYPSTAGRPHPSISEEEEGFDCLSSPERAEPPGGGWRGSLGEPPPPPRASLSSDTSA 373
             AA P   GR   +   EEE  +     E AE   G   G  G  P  PR       ++
Sbjct: 454 GRAARP---GRACSAACSEEEDEEDDEEEEDAEDSAGS-PGGRGTGPSAPR------DAS 503

Query: 374 LSYDSVKYTLVVDEHAQLELVSLRPCFG-DYSDESDSATVYDNCASVSSPYESAIGEEYE 432
           L YD+VKYTLVVDEH QLELVSLR C G  +  E DS                  GE  E
Sbjct: 504 LVYDAVKYTLVVDEHTQLELVSLRRCAGLGHDSEEDSG-----------------GEASE 546

Query: 433 EAPRPQ--PPACLSEDSTPDEPDVHFSKKFLNVFMSGRSRSSSAESFGLFSCIINGEEQE 490
           E           +S D++PD PD+ FSKKFLNVF++  SRSSS ESFGLFSC++NGEE+E
Sbjct: 547 EEAGAALLGGGQVSGDTSPDSPDLTFSKKFLNVFVNSTSRSSSTESFGLFSCLVNGEERE 606

Query: 491 QTHRAIFRFVPRHEDELELEVDDPLLVELQAEDYWYEAYNMRTGARGVFPAYYAIEVTKE 550
           QTHRA+FRF+PRH DELEL+VDDP+LVE + +D+W+  +NMRTG RGVFPA+YA  V   
Sbjct: 607 QTHRAVFRFIPRHPDELELDVDDPVLVEAEEDDFWFRGFNMRTGERGVFPAFYAHAVPGP 666

Query: 551 PEHMAALAKNSDWVDQFRVKFLGSVQVPYHKGNDVLCAAMQKIATTRRLTVHFNPPSSCV 610
            + +    ++  WV++F V+FLGSV+VP H+GN +LCAAMQKIAT R+LTVH  PP+SC 
Sbjct: 667 AKDLLGSKRSPCWVERFDVQFLGSVEVPCHQGNGILCAAMQKIATARKLTVHLRPPASCD 726

Query: 611 LEISVRGVKIGVKADDSQEAKGNKCSHFFQLKNISFCGYHPKNNKYFGFITKHPADHRFA 670
           LEIS+RGVK+ +     +     +CSHFFQ+KNISFCG HP+N+ YFGFITKHP   RFA
Sbjct: 727 LEISLRGVKLSLSGGGPE---FQRCSHFFQMKNISFCGCHPRNSCYFGFITKHPLLSRFA 783

Query: 671 CHVFVSEDSTKALAESVGRAFQQFYKQFVEYTCPTEDIYLE 711
           CHVFVS++S + +A+SVGRAF ++Y++ + Y CPTEDIYLE
Sbjct: 784 CHVFVSQESMRPVAQSVGRAFLEYYQEHLAYACPTEDIYLE 824



 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 104/345 (30%), Positives = 143/345 (41%), Gaps = 66/345 (19%)

Query: 26  HIASPPNFRLTHDISLEEFEDEDLSEITDECGISLQC------KDTLSL-RPPRAGLLSA 78
           H  SPP  R   DISLEEF+DEDLSEITD+CG+ L        KD+LSL R  +   + +
Sbjct: 14  HSLSPPGCRPPQDISLEEFDDEDLSEITDDCGLGLSYDSDHCEKDSLSLGRSEQPHPICS 73

Query: 79  GGGGAGSRLQAEMLQMDLIDATGDTPGAEDDEEDDDEERAARRPGAGPPKAESGQEPASR 138
                    Q +  + ++ID   +    EDDE++++EE      G G    + G E  + 
Sbjct: 74  --------FQDDFQEFEMIDDNEE----EDDEDEEEEEEEEEGDGEGQEGGDPGSEAPAP 121

Query: 139 GQGQSQGQSQGPGSGDTYRPKRPTTLNLFPQVPRSQDTLNNN---SLGKKHSWQDRVSRS 195
           G        + P         RPTTL L      +QD+LNNN    L +  SWQ+    S
Sbjct: 122 GPLIPSPSVEEP------HKHRPTTLRL--TTLGAQDSLNNNGGFDLVRPASWQETALCS 173

Query: 196 SSPLKTGEQTPPHEHICLSDELPPQSGPAPTTDRGT-STDSPCRRSTATQMAPPGGPPAA 254
            +P                + L    GP P TD G     SP R     +   P  PPA 
Sbjct: 174 PAP----------------EALRELPGPLPATDTGPGGAQSPVRPGCDCEGNRPAEPPA- 216

Query: 255 PPGGRGHSHRDRIHYQADVRLEA--------TEEIYLTPVQRPPDA--AEPTSAFLPPTE 304
            PGG   S    I  +AD+R  +        + +   +P     DA  A         +E
Sbjct: 217 -PGGTSPSSDPGI--EADLRSRSSGGRGGRRSSQELSSPGSDSEDAGGARLGRMISSISE 273

Query: 305 SRMSVSSDPDPAAYPSTAGRPHPSISEEEEGFDCLSSPE-RAEPP 348
           + + +SSD       S++GR     +  EE     S PE   EPP
Sbjct: 274 TELELSSD----GGSSSSGRSSHLTNSIEEASSPASEPEPPREPP 314


>gi|7706537 mitogen-activated protein kinase 8 interacting protein 2
           isoform 2 [Homo sapiens]
          Length = 797

 Score =  414 bits (1065), Expect = e-115
 Identities = 261/641 (40%), Positives = 343/641 (53%), Gaps = 84/641 (13%)

Query: 122 PGAGPPKAESGQEP-------ASRGQGQSQGQSQGPGSGDTYRPKRPTTLNLFPQVPRSQ 174
           PG   P ++ G E          RG  +S  +   PGS D+          +   +  ++
Sbjct: 190 PGGTSPSSDPGIEADLRSRSSGGRGGRRSSQELSSPGS-DSEDAGGARLGRMISSISETE 248

Query: 175 DTLNNN----SLGKKHSWQDRVSRSSSPLKTGEQTPPHEHICLSDELPP---------QS 221
             L+++    S G+     + +  +SSP    E  PP E       LP          +S
Sbjct: 249 LELSSDGGSSSSGRSSHLTNSIEEASSP--ASEPEPPREPPRRPAFLPVGPDDTNSEYES 306

Query: 222 GPAPTTDRGTSTDSP-------------------CRRSTATQMAPPGGPPAAPPGGRGHS 262
           G     D     DSP                   C     +    P G P +P GG    
Sbjct: 307 GSESEPDLSEDADSPWLLSNLVSRMISEGSSPIRCPGQCLSPAPRPPGEPVSPAGGAAQD 366

Query: 263 HRD--RIHYQADVRLEATEEIYLTPVQRP----PDAAEPTSAFLPPTESRMSVS---SDP 313
            +D         V L   E +   P   P    P  A+P         +R +++   + P
Sbjct: 367 SQDPEAAAGPGGVELVDMETLCAPPPPAPAAPRPGPAQPGPCLFLSNPTRDTITPLWAAP 426

Query: 314 DPAAYPSTAGRPHPSISEEEEGFDCLSSPERAEPPGGGWRGSLGEPPPPPRASLSSDTSA 373
             AA P   GR   +   EEE  +     E AE   G   G  G  P  PR       ++
Sbjct: 427 GRAARP---GRACSAACSEEEDEEDDEEEEDAEDSAGS-PGGRGTGPSAPR------DAS 476

Query: 374 LSYDSVKYTLVVDEHAQLELVSLRPCFG-DYSDESDSATVYDNCASVSSPYESAIGEEYE 432
           L YD+VKYTLVVDEH QLELVSLR C G  +  E DS                  GE  E
Sbjct: 477 LVYDAVKYTLVVDEHTQLELVSLRRCAGLGHDSEEDSG-----------------GEASE 519

Query: 433 EAPRPQ--PPACLSEDSTPDEPDVHFSKKFLNVFMSGRSRSSSAESFGLFSCIINGEEQE 490
           E           +S D++PD PD+ FSKKFLNVF++  SRSSS ESFGLFSC++NGEE+E
Sbjct: 520 EEAGAALLGGGQVSGDTSPDSPDLTFSKKFLNVFVNSTSRSSSTESFGLFSCLVNGEERE 579

Query: 491 QTHRAIFRFVPRHEDELELEVDDPLLVELQAEDYWYEAYNMRTGARGVFPAYYAIEVTKE 550
           QTHRA+FRF+PRH DELEL+VDDP+LVE + +D+W+  +NMRTG RGVFPA+YA  V   
Sbjct: 580 QTHRAVFRFIPRHPDELELDVDDPVLVEAEEDDFWFRGFNMRTGERGVFPAFYAHAVPGP 639

Query: 551 PEHMAALAKNSDWVDQFRVKFLGSVQVPYHKGNDVLCAAMQKIATTRRLTVHFNPPSSCV 610
            + +    ++  WV++F V+FLGSV+VP H+GN +LCAAMQKIAT R+LTVH  PP+SC 
Sbjct: 640 AKDLLGSKRSPCWVERFDVQFLGSVEVPCHQGNGILCAAMQKIATARKLTVHLRPPASCD 699

Query: 611 LEISVRGVKIGVKADDSQEAKGNKCSHFFQLKNISFCGYHPKNNKYFGFITKHPADHRFA 670
           LEIS+RGVK+ +     +     +CSHFFQ+KNISFCG HP+N+ YFGFITKHP   RFA
Sbjct: 700 LEISLRGVKLSLSGGGPE---FQRCSHFFQMKNISFCGCHPRNSCYFGFITKHPLLSRFA 756

Query: 671 CHVFVSEDSTKALAESVGRAFQQFYKQFVEYTCPTEDIYLE 711
           CHVFVS++S + +A+SVGRAF ++Y++ + Y CPTEDIYLE
Sbjct: 757 CHVFVSQESMRPVAQSVGRAFLEYYQEHLAYACPTEDIYLE 797



 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 74/276 (26%), Positives = 106/276 (38%), Gaps = 51/276 (18%)

Query: 88  QAEMLQMDLIDATGDTPGAEDDEEDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQS 147
           Q +  + ++ID   +    EDDE++++EE      G G    + G E  + G        
Sbjct: 48  QDDFQEFEMIDDNEE----EDDEDEEEEEEEEEGDGEGQEGGDPGSEAPAPGPLIPSPSV 103

Query: 148 QGPGSGDTYRPKRPTTLNLFPQVPRSQDTLNNN---SLGKKHSWQDRVSRSSSPLKTGEQ 204
           + P         RPTTL L      +QD+LNNN    L +  SWQ+    S +P      
Sbjct: 104 EEP------HKHRPTTLRL--TTLGAQDSLNNNGGFDLVRPASWQETALCSPAP------ 149

Query: 205 TPPHEHICLSDELPPQSGPAPTTDRGT-STDSPCRRSTATQMAPPGGPPAAPPGGRGHSH 263
                     + L    GP P TD G     SP R     +   P  PPA  PGG   S 
Sbjct: 150 ----------EALRELPGPLPATDTGPGGAQSPVRPGCDCEGNRPAEPPA--PGGTSPSS 197

Query: 264 RDRIHYQADVRLEA--------TEEIYLTPVQRPPDA--AEPTSAFLPPTESRMSVSSDP 313
              I  +AD+R  +        + +   +P     DA  A         +E+ + +SSD 
Sbjct: 198 DPGI--EADLRSRSSGGRGGRRSSQELSSPGSDSEDAGGARLGRMISSISETELELSSD- 254

Query: 314 DPAAYPSTAGRPHPSISEEEEGFDCLSSPE-RAEPP 348
                 S++GR     +  EE     S PE   EPP
Sbjct: 255 ---GGSSSSGRSSHLTNSIEEASSPASEPEPPREPP 287


>gi|7705318 GULP, engulfment adaptor PTB domain containing 1 [Homo
           sapiens]
          Length = 304

 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 44/135 (32%), Positives = 68/135 (50%), Gaps = 8/135 (5%)

Query: 567 FRVKFLGSVQVPYHKGNDVLCAAMQKIATTRRLTVHFNPPSSCV-LEISVRGVKIGVKAD 625
           +  KFLGS +V   KG +V+  A++K+   R +          V L+IS+ GVKI     
Sbjct: 27  YNAKFLGSTEVEQPKGTEVVRDAVRKLKFARHIKKSEGQKIPKVELQISIYGVKI----- 81

Query: 626 DSQEAKGNKCSHFFQLKNISFCGYHPKNNKYFGFITKHPADHRFACHVFVSEDSTKALAE 685
              E K  +  H  QL  ISFC     + + F FI K    ++  C+VF SE   + +  
Sbjct: 82  --LEPKTKEVQHNCQLHRISFCADDKTDKRIFTFICKDSESNKHLCYVFDSEKCAEEITL 139

Query: 686 SVGRAFQQFYKQFVE 700
           ++G+AF   Y++F+E
Sbjct: 140 TIGQAFDLAYRKFLE 154


>gi|19924099 synapsin I isoform Ia [Homo sapiens]
          Length = 705

 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 70/276 (25%), Positives = 95/276 (34%), Gaps = 43/276 (15%)

Query: 100 TGDTPGAEDDEEDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGPGSGDTYRPK 159
           T   P     ++    +    +PG GP +     +     QGQ      GP +G     +
Sbjct: 448 TSQQPAGPPAQQRPPPQGGPPQPGPGPQRQGPPLQQRPPPQGQQHLSGLGPPAGSPLPQR 507

Query: 160 RPTTLNLFPQVPRSQDTLNNNSLGKKHSWQDRVSRSSSPLKTGEQTPPHEHICLSDELPP 219
            P+  +  PQ P SQ        G          R S P+  G   PP      S     
Sbjct: 508 LPSPTSA-PQQPASQAAPPTQGQG----------RQSRPVAGGPGAPPAARPPASPSPQR 556

Query: 220 QSGPAPTTDRGTSTDSPCRRSTATQMAPPGG-----PPAAPPGGRGHSHRDRIHYQADVR 274
           Q+GP P   R TS   P     +   APPGG     PP  PPG  G + +     QA   
Sbjct: 557 QAGP-PQATRQTSVSGPAPPKASG--APPGGQQRQGPPQKPPGPAGPTRQAS---QAGPV 610

Query: 275 LEATEEIYLTPVQRPPDAAEPTSAFLPPTESRMSVSSDPDPAAYPSTAGRPHPSISEEEE 334
                     P  + P  + P  A  P  +     S D  P A  +  G PHP +++ + 
Sbjct: 611 PRTGP-----PTTQQPRPSGPGPAGRPKPQLAQKPSQDVPPPATAAAGGPPHPQLNKSQS 665

Query: 335 GFDCLSSPERAEPPGGGWRGSLGEPPPPPRASLSSD 370
             +  + PE                P PPR SLS D
Sbjct: 666 LTNAFNLPE----------------PAPPRPSLSQD 685


>gi|19924097 synapsin I isoform Ib [Homo sapiens]
          Length = 669

 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 64/253 (25%), Positives = 87/253 (34%), Gaps = 36/253 (14%)

Query: 100 TGDTPGAEDDEEDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGPGSGDTYRPK 159
           T   P     ++    +    +PG GP +     +     QGQ      GP +G     +
Sbjct: 448 TSQQPAGPPAQQRPPPQGGPPQPGPGPQRQGPPLQQRPPPQGQQHLSGLGPPAGSPLPQR 507

Query: 160 RPTTLNLFPQVPRSQDTLNNNSLGKKHSWQDRVSRSSSPLKTGEQTPPHEHICLSDELPP 219
            P+  +  PQ P SQ        G          R S P+  G   PP      S     
Sbjct: 508 LPSPTSA-PQQPASQAAPPTQGQG----------RQSRPVAGGPGAPPAARPPASPSPQR 556

Query: 220 QSGPAPTTDRGTSTDSPCRRSTATQMAPPGG-----PPAAPPGGRGHSHRDRIHYQADVR 274
           Q+GP P   R TS   P     +   APPGG     PP  PPG  G + +     QA   
Sbjct: 557 QAGP-PQATRQTSVSGPAPPKASG--APPGGQQRQGPPQKPPGPAGPTRQAS---QAGPV 610

Query: 275 LEATEEIYLTPVQRPPDAAEPTSAFLPPTESRMSVSSDPDPAAYPSTAGRPHPSISEEEE 334
                     P  + P  + P  A  P  +     S D  P A  +  G PHP +     
Sbjct: 611 PRTGP-----PTTQQPRPSGPGPAGRPKPQLAQKPSQDVPPPATAAAGGPPHPQLK---- 661

Query: 335 GFDCLSSPERAEP 347
                +SP +A+P
Sbjct: 662 -----ASPAQAQP 669



 Score = 32.3 bits (72), Expect = 1.6
 Identities = 47/158 (29%), Positives = 56/158 (35%), Gaps = 26/158 (16%)

Query: 219 PQSGPAPTTDRGTSTDSPCRRSTATQMAPP-GGPPAAPPGGR--GHSHRDRIHYQADVRL 275
           P  G  P    G  T        A Q  PP GGPP   PG +  G   + R   Q    L
Sbjct: 437 PSPGALPL---GRQTSQQPAGPPAQQRPPPQGGPPQPGPGPQRQGPPLQQRPPPQGQQHL 493

Query: 276 EATEEIYLTPV-QRPPDAA----EPTSAFLPPTES--RMSVSSDPDPAAYPSTAGRPHPS 328
                   +P+ QR P       +P S   PPT+   R S      P A P  A RP  S
Sbjct: 494 SGLGPPAGSPLPQRLPSPTSAPQQPASQAAPPTQGQGRQSRPVAGGPGAPP--AARPPAS 551

Query: 329 ISEEEEGFDCLSSPERAEPPGGGWRGSLGEPPPPPRAS 366
                       SP+R   P    R +    P PP+AS
Sbjct: 552 -----------PSPQRQAGPPQATRQTSVSGPAPPKAS 578


>gi|116284398 WAS/WASL interacting protein family, member 1 [Homo
           sapiens]
          Length = 503

 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 68/268 (25%), Positives = 97/268 (36%), Gaps = 39/268 (14%)

Query: 121 RPGAGPPKAESGQEPASRGQGQSQGQSQGPGSGDTYRPKRPTTLNLFPQVPRSQDTLNNN 180
           +P + PP   S   P  +    ++G    PG      P++P+     P  P ++ T    
Sbjct: 179 KPDSIPPPVPSTPRPI-QSSPHNRGSPPVPGG-----PRQPSPGPTPPPFPGNRGT---- 228

Query: 181 SLGKKHSWQDRVSRSSSPLKTGEQTPPHEHICLSDELPPQSGPA--------------PT 226
           +LG     Q  +S SSSP       PP     L D+ PP   P               P 
Sbjct: 229 ALGGGSIRQSPLS-SSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPP 287

Query: 227 TDRGTSTDSPCRRSTATQMAPPG------GPPAAPPGGRGHSHRDRIHYQADVRLEATEE 280
            +      S  R S ++Q  PP       GPP  PP   G+    R+  Q ++ L ++  
Sbjct: 288 QNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLP-QRNLSLSSSTP 346

Query: 281 IYLTPVQRPPDAAEPTSAFLPPTES---RMSVSSDPDPAAYPSTAGRPHPSISE--EEEG 335
              +P +  P    P+    PP      R      P P +   +  R  P+  +     G
Sbjct: 347 PLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSG 406

Query: 336 FDCLSSPERAEPPGGGWRGSLGEPPPPP 363
            D   S  R  PP    R S G PPPPP
Sbjct: 407 VDSPRSGPR--PPLPPDRPSAGAPPPPP 432


>gi|38373695 WAS/WASL interacting protein family, member 1 [Homo
           sapiens]
          Length = 503

 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 68/268 (25%), Positives = 97/268 (36%), Gaps = 39/268 (14%)

Query: 121 RPGAGPPKAESGQEPASRGQGQSQGQSQGPGSGDTYRPKRPTTLNLFPQVPRSQDTLNNN 180
           +P + PP   S   P  +    ++G    PG      P++P+     P  P ++ T    
Sbjct: 179 KPDSIPPPVPSTPRPI-QSSPHNRGSPPVPGG-----PRQPSPGPTPPPFPGNRGT---- 228

Query: 181 SLGKKHSWQDRVSRSSSPLKTGEQTPPHEHICLSDELPPQSGPA--------------PT 226
           +LG     Q  +S SSSP       PP     L D+ PP   P               P 
Sbjct: 229 ALGGGSIRQSPLS-SSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPP 287

Query: 227 TDRGTSTDSPCRRSTATQMAPPG------GPPAAPPGGRGHSHRDRIHYQADVRLEATEE 280
            +      S  R S ++Q  PP       GPP  PP   G+    R+  Q ++ L ++  
Sbjct: 288 QNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLP-QRNLSLSSSTP 346

Query: 281 IYLTPVQRPPDAAEPTSAFLPPTES---RMSVSSDPDPAAYPSTAGRPHPSISE--EEEG 335
              +P +  P    P+    PP      R      P P +   +  R  P+  +     G
Sbjct: 347 PLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSG 406

Query: 336 FDCLSSPERAEPPGGGWRGSLGEPPPPP 363
            D   S  R  PP    R S G PPPPP
Sbjct: 407 VDSPRSGPR--PPLPPDRPSAGAPPPPP 432


>gi|149158690 HLA-B associated transcript-2 [Homo sapiens]
          Length = 2157

 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 89/332 (26%), Positives = 118/332 (35%), Gaps = 50/332 (15%)

Query: 29   SPPNFRLTHDISLEEFED-EDLSEITDECGISLQCKDTLSLRPPRAGLLSAGGGGAGSRL 87
            SP       D + EE+E   + S+ T E     +    + L P   G    GGGGA   +
Sbjct: 1306 SPDLSNQNSDQANEEWETASESSDFTSERRGDKEAPPPVLLTPKAVGTPGGGGGGAVPGI 1365

Query: 88   QAEMLQMDLIDATGDTPGAEDDEEDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQS 147
             A M + DL     D        +    ER  RRPG G     SG   +S G G   G  
Sbjct: 1366 SA-MSRGDLSQRAKDLSKRSFSSQRPGMERQNRRPGPGGKAGSSGS--SSGGGGGGPGGR 1422

Query: 148  QGPGSGD---------TYRP--KRPTTLNLFPQVP------RSQDTLNNNSLGKKHSWQD 190
             GPG GD           RP  +RP  L L P  P      R    +++N  G + +   
Sbjct: 1423 TGPGRGDKRSWPSPKNRSRPPEERPPGLPLPPPPPSSSAVFRLDQVIHSNPAGIQQALAQ 1482

Query: 191  RVSRSSSPLKTGEQTPPHEHICLSDELP--PQSGPAPTTDRGTSTDSPCRRSTATQMAPP 248
              SR       G  T P  H      LP  PQ GP+P   R  +   P R ++     P 
Sbjct: 1483 LSSRQ------GSVTAPGGHPRHKPGLPQAPQ-GPSP---RPPTRYEPQRVNSGLSSDPH 1532

Query: 249  GGPPAAPPGGRGHSHRDRIHYQADVRLEATEEIYLTPVQRPPDAAEPTSAFLPPTESRMS 308
               P     G G + RD     A V     +     P  R P+  +  S  LPP  S   
Sbjct: 1533 FEEPGPMVRGVGGTPRD----SAGVSPFPPKRRERPP--RKPELLQEES--LPPPHSSGF 1584

Query: 309  VSSDPDPAAYPSTAGRPHPSISEEEEGFDCLS 340
            + S P+          P P     + G + L+
Sbjct: 1585 LGSKPE---------GPGPQAESRDTGTEALT 1607



 Score = 33.9 bits (76), Expect = 0.54
 Identities = 99/433 (22%), Positives = 132/433 (30%), Gaps = 102/433 (23%)

Query: 14  ASPPAASPFLGLHIASPPNFRLTHDISLEEFEDEDLSEITDECGISLQCKDTLSLRPPRA 73
           A PPA    L    A PP    T +   EE      ++ T   G++             A
Sbjct: 519 APPPAVPKELPAPPAPPPASAPTPETEPEEPAQAPPAQSTPTPGVAA------------A 566

Query: 74  GLLSAGGGGAGSR----LQAEMLQMDLIDATGD----------TPGAEDDEEDDDEERAA 119
             L +GGG   S      +A  ++  L    G           TP     E   D     
Sbjct: 567 PTLVSGGGSTSSTSSGSFEASPVEPQLPSKEGPEPPEEVPPPTTPPVPKVEPKGDGIGPT 626

Query: 120 RRP---GAGPPKAESGQEPASRGQGQSQ-------------GQSQGPGSGDTYRPKRPTT 163
           R+P   G G PK +    P  + Q Q Q              Q   P +     P +P T
Sbjct: 627 RQPPSQGLGYPKYQKSLPPRFQRQQQEQLLKQQQQHQWQQHQQGSAPPTPVPPSPPQPVT 686

Query: 164 LNLFPQV---PRSQDTLNNNSLGKKHS---------WQ-------DRVSRSSSPLKTGEQ 204
           L   P     P     L   +LG+            W         R+ +   PL   + 
Sbjct: 687 LGAVPAPQAPPPPPKALYPGALGRPPPMPPMNFDPRWMMIPPYVDPRLLQGRPPL---DF 743

Query: 205 TPPHEHICLSDELPPQSGPAPTTDRGTSTDSPCRRSTATQMAPPGGPP------------ 252
            PP  H       P    P   +D G S+  P  R     +   G PP            
Sbjct: 744 YPPGVH-------PSGLVPRERSDSGGSSSEPFDRHAPAMLRERGTPPVDPKLAWVGDVF 796

Query: 253 -AAPPGGRGHSHRDRIHYQADVRLEATEEIYLTPVQRPPD-----AAEPTSAFLPPTESR 306
            A P   R  +   R     D +   +E     PV  PP         P +    P  SR
Sbjct: 797 TATPAEPRPLTSPLRQAADEDDKGMRSE---TPPVPPPPPYLASYPGFPENGAPGPPISR 853

Query: 307 MSVSSDPDPAAYPSTAG--------RPHPSISEEEEGFDCLSSPERAEPPGGGWRGSLGE 358
             +  +P P   P   G         P P     +E    L+ PE    P  G  GS G+
Sbjct: 854 FPL-EEPGPRPLPWPPGSDEVAKIQTPPPKKEPPKEETAQLTGPEAGRKPARG-VGSGGQ 911

Query: 359 PPPPPRASLSSDT 371
            PPPPR    ++T
Sbjct: 912 GPPPPRRESRTET 924



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 28/89 (31%), Positives = 36/89 (40%), Gaps = 18/89 (20%)

Query: 168  PQVPRSQDTLNNNSLGKKHSWQDRVSRSSSPLKTGEQTPPHEHICLSDELPPQSGPAPTT 227
            P  PR +      S G ++    +  R     +TG +T  HE      +L P    APT 
Sbjct: 1076 PPAPRGRTASETRSEGSEYEEIPKRRRQRGS-ETGSET--HE-----SDLAPSDKEAPTP 1127

Query: 228  DRGTSTDSPCRRSTATQMAPPGGPPAAPP 256
              GT T  P        +APP  PP APP
Sbjct: 1128 KEGTLTQVP--------LAPP--PPGAPP 1146



 Score = 30.0 bits (66), Expect = 7.7
 Identities = 56/264 (21%), Positives = 85/264 (32%), Gaps = 50/264 (18%)

Query: 108 DDEEDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGPGSGDT--YRPKRPTTLN 165
           D++    ++R    P A P    +   P +  +      +  P S  T    P+ P    
Sbjct: 494 DEKFGAPDKRLKAEPAAPPAAPSTPAPPPAVPKELPAPPAPPPASAPTPETEPEEPA--- 550

Query: 166 LFPQVPRSQDTLNNNSLGKKHSWQDRVSRSSSPLKTGEQTPPHEHICLSDELPPQSGPAP 225
              Q P +Q T                S SS+   + E +P      +  +LP + GP P
Sbjct: 551 ---QAPPAQSTPTPGVAAAPTLVSGGGSTSSTSSGSFEASP------VEPQLPSKEGPEP 601

Query: 226 TTDRGTSTDSPCRRSTATQMAPPG---GPPAAPPG-GRGHSHRDRIHYQADV--RLEATE 279
             +    T  P       ++ P G   GP   PP  G G+       YQ  +  R +  +
Sbjct: 602 PEEVPPPTTPP-----VPKVEPKGDGIGPTRQPPSQGLGYPK-----YQKSLPPRFQRQQ 651

Query: 280 EIYLTPVQRPPDAAEPTSAFLPPTESRMSVSSDPDPAAYPSTAGRPHPSISEEEEGFDCL 339
           +  L   Q+     +      PPT    S        A P+    P              
Sbjct: 652 QEQLLKQQQQHQWQQHQQGSAPPTPVPPSPPQPVTLGAVPAPQAPP-------------- 697

Query: 340 SSPERAEPPGGGWRGSLGEPPPPP 363
                  PP   + G+LG PPP P
Sbjct: 698 ------PPPKALYPGALGRPPPMP 715


>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
          Length = 904

 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 67/281 (23%), Positives = 98/281 (34%), Gaps = 54/281 (19%)

Query: 115 EERAARRPGAGPPKAESGQEPASRG---------------QGQSQGQSQGPGSGDTYRPK 159
           E+R +  P   P K E  +    +G               + Q+Q  S   GS  +   +
Sbjct: 446 EKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDE 505

Query: 160 RPTTLNLFPQVPRSQDTLNNNSLGKKHSWQDRVSRSSSPLKTGEQTPPHEHICLSDELPP 219
           RP            +  + N  +G++       S S SP K  ++T P      S   PP
Sbjct: 506 RP-----------KRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSPPP 554

Query: 220 -----QSGPAPTTDRGTSTDSPCRRSTATQMAPPGGPPAAPPGGRGHSHRDRIHYQADVR 274
                   PAP   R  +   P RR T          P+ PP  R  S R    Y   ++
Sbjct: 555 TRRRRSPSPAPPPRRRRTPTPPPRRRT----------PSPPPRRRSPSPR---RYSPPIQ 601

Query: 275 LEATEEIYLTPVQR----PPDAAEPTSAFLPPTESRMSVSSDPDPAAYPSTAGRPHPSIS 330
              +      P +R    PP   +  ++  PP + R+S S  P   + P T  R     S
Sbjct: 602 RRYSPS---PPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSS 658

Query: 331 EEEEGFDCLSSPERAEPPGGGWRGSLGEPPPPPRASLSSDT 371
           +  +G     S   A  P    R S   P P PRA  +S +
Sbjct: 659 KHRKGSSPSRSTREARSPQPNKRHS---PSPRPRAPQTSSS 696



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 58/255 (22%), Positives = 84/255 (32%), Gaps = 22/255 (8%)

Query: 117 RAARRPG-AGPPKAESGQEPASRGQGQSQGQSQGPGSGDTYRPKRPTTLNLFPQVPRSQD 175
           R  R P  A PP+      P  R +  S    +   S   Y P  P      P  P  + 
Sbjct: 556 RRRRSPSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSP--PIQRRYSPSPPPKRR 613

Query: 176 TLNNNSLGKKHSWQD-----RVSRSSSPLKTGEQTPPHEHICLSDELPPQSGPAPTTDRG 230
           T +     K+ +        RVS S  P +            LS +    S P+ +T   
Sbjct: 614 TASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREA 673

Query: 231 TSTDSPCRRSTATQMAPPGGPPAAPPGGRGHSHRDRIHYQADVRLEATEEIYLTP-VQRP 289
            S     R S + +   P    + PP  RG S   +              +  TP  ++ 
Sbjct: 674 RSPQPNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEPKKI 733

Query: 290 PDAAEPTSAFLPPTESRMSVSSDPDPAA-------------YPSTAGRPHPSISEEEEGF 336
             AA P+   +    S  SVS  P+PAA              PST   P   + + +   
Sbjct: 734 KKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPSPVQSQSPSTNWSPAVPVKKAKSPT 793

Query: 337 DCLSSPERAEPPGGG 351
              S P  ++  GGG
Sbjct: 794 PSPSPPRNSDQEGGG 808


>gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens]
          Length = 888

 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 36/128 (28%), Positives = 55/128 (42%), Gaps = 8/128 (6%)

Query: 422 PYESAIGEEYEEAPRPQPPACLSEDSTPDEPDVHFSKKFLNVFMSGRSRSSSAESFGLFS 481
           PY++A+G      P P   A     STP       +       M  R  + S +      
Sbjct: 387 PYQAALGTLNPPLPPPPLLAATVLASTPPGATAAAAA----AGMGPRPMAGSTDQIAH-- 440

Query: 482 CIINGEEQEQTHRAIFRFVPRHEDELELEVDDPLLVELQAEDYWYEAYNMRTGARGVFPA 541
             +  + +   + AI+ + PR EDELEL   +  LV  + +D W++  +M T   GVFP 
Sbjct: 441 --LRPQTRPSVYVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPG 498

Query: 542 YYAIEVTK 549
            Y   VT+
Sbjct: 499 NYVAPVTR 506



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 18/53 (33%), Positives = 29/53 (54%)

Query: 491 QTHRAIFRFVPRHEDELELEVDDPLLVELQAEDYWYEAYNMRTGARGVFPAYY 543
           + HR +  + P+ E ELEL+  D + V  + ED W++    R G  G+FP  +
Sbjct: 832 ERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSF 884


>gi|130502140 NEZHA isoform 2 [Homo sapiens]
          Length = 1249

 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 92/371 (24%), Positives = 138/371 (37%), Gaps = 42/371 (11%)

Query: 9   LGGGAASPPAASPFLGLHIASPPNFRLTHDISLEEFED--EDLSEITDECGISLQCKDTL 66
           L G A+ PPA S      +AS P      ++ +  F +  + L +   E G       T 
Sbjct: 533 LVGEASKPPAPSEGSPKAVASSPA-ATNSEVKMTSFAERKKQLVKAEAEAGAG---SPTS 588

Query: 67  SLRPPRAGLLSAGGGGAGSRLQAEMLQMDLIDATGDTPGAEDDEEDDDEERAARRPGAGP 126
           +  PP A  LS+      +RL+ +   ++      +   A+  +          +P    
Sbjct: 589 TPAPPEA--LSSEMSELSARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREAS 646

Query: 127 PKAESGQEPASRGQGQSQGQSQGPGSGD-TYRPKRPTTLNLFPQVPRSQDTLNNNSLGKK 185
            +AE+  E A  G      +  G G G+ T RPK  T       VP       N ++ K 
Sbjct: 647 GEAEAEAEEADSGPVPGGERPAGEGQGEPTSRPKAVTFSPDLGPVPHEGLGEYNRAVSKL 706

Query: 186 HSWQDRVSRSSSPLKTGEQ---TPPHEHICLSDELPPQSG---PAPTTDRGTSTDSPCRR 239
            +    + R    L   +Q    PP          PP +    P PTT    ++ SP RR
Sbjct: 707 SAALSSLQRDMQRLTDQQQRLLAPPEA----PGSAPPPAAWVIPGPTTGPKAASPSPARR 762

Query: 240 STATQMAPPGGPPAAPPGGRGHSHRDRIHYQADVRLEATEEIYLTPVQRPP---DAAEPT 296
             AT+ +P  GP  +P   R   H       A++RL       LT V  PP   D+    
Sbjct: 763 VPATRRSPGPGPSQSP---RSPKHT----RPAELRLAP-----LTRVLTPPHDVDSLPHL 810

Query: 297 SAFLP---PTESRMSV-----SSDPDPAAYPSTAGRPHPSISEEEEGFDCLSSPERAEPP 348
             F P   P ++R S+     +   +PAA P     P  S+++     +   SP  AE  
Sbjct: 811 RKFSPSQVPVQTRSSILLAEETPPEEPAARPGLIEIPLGSLADPAAEDEGDGSPAGAEDS 870

Query: 349 GGGWRGSLGEP 359
                 S GEP
Sbjct: 871 LEEEASSEGEP 881


>gi|122937255 NEZHA isoform 1 [Homo sapiens]
          Length = 1276

 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 92/371 (24%), Positives = 138/371 (37%), Gaps = 42/371 (11%)

Query: 9   LGGGAASPPAASPFLGLHIASPPNFRLTHDISLEEFED--EDLSEITDECGISLQCKDTL 66
           L G A+ PPA S      +AS P      ++ +  F +  + L +   E G       T 
Sbjct: 560 LVGEASKPPAPSEGSPKAVASSPA-ATNSEVKMTSFAERKKQLVKAEAEAGAG---SPTS 615

Query: 67  SLRPPRAGLLSAGGGGAGSRLQAEMLQMDLIDATGDTPGAEDDEEDDDEERAARRPGAGP 126
           +  PP A  LS+      +RL+ +   ++      +   A+  +          +P    
Sbjct: 616 TPAPPEA--LSSEMSELSARLEEKRRAIEAQKRRIEAIFAKHRQRLGKSAFLQVQPREAS 673

Query: 127 PKAESGQEPASRGQGQSQGQSQGPGSGD-TYRPKRPTTLNLFPQVPRSQDTLNNNSLGKK 185
            +AE+  E A  G      +  G G G+ T RPK  T       VP       N ++ K 
Sbjct: 674 GEAEAEAEEADSGPVPGGERPAGEGQGEPTSRPKAVTFSPDLGPVPHEGLGEYNRAVSKL 733

Query: 186 HSWQDRVSRSSSPLKTGEQ---TPPHEHICLSDELPPQSG---PAPTTDRGTSTDSPCRR 239
            +    + R    L   +Q    PP          PP +    P PTT    ++ SP RR
Sbjct: 734 SAALSSLQRDMQRLTDQQQRLLAPPEA----PGSAPPPAAWVIPGPTTGPKAASPSPARR 789

Query: 240 STATQMAPPGGPPAAPPGGRGHSHRDRIHYQADVRLEATEEIYLTPVQRPP---DAAEPT 296
             AT+ +P  GP  +P   R   H       A++RL       LT V  PP   D+    
Sbjct: 790 VPATRRSPGPGPSQSP---RSPKHT----RPAELRLAP-----LTRVLTPPHDVDSLPHL 837

Query: 297 SAFLP---PTESRMSV-----SSDPDPAAYPSTAGRPHPSISEEEEGFDCLSSPERAEPP 348
             F P   P ++R S+     +   +PAA P     P  S+++     +   SP  AE  
Sbjct: 838 RKFSPSQVPVQTRSSILLAEETPPEEPAARPGLIEIPLGSLADPAAEDEGDGSPAGAEDS 897

Query: 349 GGGWRGSLGEP 359
                 S GEP
Sbjct: 898 LEEEASSEGEP 908


>gi|5032069 splicing factor 3b, subunit 4 [Homo sapiens]
          Length = 424

 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 58/193 (30%), Positives = 77/193 (39%), Gaps = 45/193 (23%)

Query: 180 NSLGKKH-SWQDRVSRSSSPLKTGEQTPPHEHICLSDELPPQSGPAP-TTDRGTSTDSPC 237
           +S G++H S  +R+  + +PL   ++  PH+    +D  PP S P P  +  G+    P 
Sbjct: 181 DSKGERHGSAAERLLAAQNPLSQADR--PHQ--LFADAPPPPSAPNPVVSSLGSGLPPP- 235

Query: 238 RRSTATQMAPPGG--PPAAPPGGRGHSHRDRIHYQADVRLEATEEIYLTPVQRPPDAA-- 293
                  M PPG   PP  PPG                 L       + P   PP AA  
Sbjct: 236 ------GMPPPGSFPPPVPPPGA----------------LPPGIPPAMPPPPMPPGAAGH 273

Query: 294 EPTSAFLPPTESRMSVSSDPDPAAYPSTAGRPHPSISEEE---EGFDCLSSPERAEPPGG 350
            P SA  P         S P P  +P   G PHP +S+ +    G   L  P  A PPG 
Sbjct: 274 GPPSAGTPGAGHPGHGHSHPHP--FP-PGGMPHPGMSQMQLAHHGPHGLGHP-HAGPPGS 329

Query: 351 GWRGSLGEPPPPP 363
           G     G+PPP P
Sbjct: 330 G-----GQPPPRP 337


>gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens]
          Length = 882

 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 22/67 (32%), Positives = 37/67 (55%)

Query: 495 AIFRFVPRHEDELELEVDDPLLVELQAEDYWYEAYNMRTGARGVFPAYYAIEVTKEPEHM 554
           A++ + P+  DELEL   +   V  + +D W++  ++RTG  GVFP  Y   V++ P   
Sbjct: 471 ALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVPAGG 530

Query: 555 AALAKNS 561
           A   +N+
Sbjct: 531 AGPPRNN 537



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 75/369 (20%), Positives = 123/369 (33%), Gaps = 54/369 (14%)

Query: 197 SPLKTGEQTPPHEHICLSDELPPQSGPAPTTDRGTSTDSPCRRSTATQMAPPGGPPAAPP 256
           SPL  G  T  H          P SG   +    T    P      T  A    P A+PP
Sbjct: 542 SPLAKGITTTMH----------PGSGSLSSLATATRPALPI----TTPQAHAQHPTASPP 587

Query: 257 GGRGHSHRDRIHYQADVRLEATEEIYLTPVQRPPDAAEPTSAFLPPTESRMSVSSDPDPA 316
            G        + + A            T       A +  +A + P  ++ S      P+
Sbjct: 588 TG------SCLRHSAQPTASQARSTISTAAHSAAQAQDRPTATVSPLRTQNS------PS 635

Query: 317 AYPSTAGRPHPSISEEEE-----------GFDCLSSPERAEPPG---GGWRGSLGEPPPP 362
             P+T+ RPH  +S +                  S+     PP        G  G  P  
Sbjct: 636 RLPATSLRPHSVVSPQHSHQPPVQMCPRPAIPLTSAASAITPPNVSAANLNGEAGGGPIG 695

Query: 363 PRASLSSDTSALSYDSVKYTLVVDEHAQLELVSLRPCFGDYSDESDSATVYDNCASVSSP 422
             ++ S   +    D  K      +   L+L++              +  +D   +V + 
Sbjct: 696 VLSTSSPTNTGCKLDEKKSEKKEKKSGLLKLLAGASTKKKSRSPPSVSPTHDPQVAVDAL 755

Query: 423 YESAIGEEYEEAP-RPQPPACLSEDSTPD----EPDVHFSKKFLNVFMSGRSRSSSAESF 477
            + A+G E        +  +C  E         EP +H     L++  +  SR +     
Sbjct: 756 LQGAVGPEVSSLSIHGRAGSCPIESEMQGAMGMEP-LHRKAGSLDLNFTSPSRQAP---- 810

Query: 478 GLFSCIINGEEQ---EQTHRAIFRFVPRHEDELELEVDDPLLVELQAEDYWYEAYNMRTG 534
            L    I  E +    + +R +  + P+ E E+EL+  D + V  + ED WY+    R G
Sbjct: 811 -LSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNG 869

Query: 535 ARGVFPAYY 543
             G+FP  +
Sbjct: 870 RTGLFPGSF 878


>gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Homo
           sapiens]
          Length = 999

 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 67/261 (25%), Positives = 89/261 (34%), Gaps = 57/261 (21%)

Query: 115 EERAARRPGAGPPKAESG-QEPASRGQGQSQGQSQGPGSGDTYRPKRPTTLNLFPQVPRS 173
           E RAA      PP A S  Q    +      G+S+G G G    P+R T     P  P  
Sbjct: 2   EPRAAAAGEPEPPAASSSFQARLWKNLQLGVGRSKGGGGGRAGGPERRTADTPSPSPPPP 61

Query: 174 QDTLNNNSLG-----------KKHSWQDRVSRSSSPLKTGEQTPPHEHICLSDELPPQSG 222
             T N  + G           K+    DRV  SS P           ++C S   P + G
Sbjct: 62  VGTGNAPARGSGAGSRWSGFKKRKQVLDRVFSSSQP-----------NLCCSSPEPLEPG 110

Query: 223 PAPTTDRGTSTDSPCRRSTATQMAPPGGPPAAPPGGRGHSHRDRIHYQADVRLEATEEIY 282
            A   ++G    S  RR     + P    PAA  G  G +                    
Sbjct: 111 GAGRAEQG----STLRRRIREHLLPAVKGPAAASGAAGGT-------------------- 146

Query: 283 LTPVQRPPDAAEPTSAFLPPTESRMSVSSDPDPAAYPSTAGRPHPSISEEEEGFDCLSSP 342
             P  R PD+A  +S+      +  S+SS P P   P    R     +  +     L   
Sbjct: 147 -PPGGRSPDSAPSSSS------ASSSLSSSPQP---PPRGDRARDEGARRQGPGAHLCHQ 196

Query: 343 ERAEPPGGGWRGSLGEPPPPP 363
           + +  PG      L EPPPPP
Sbjct: 197 KSSSLPGTACLEQLLEPPPPP 217


>gi|112734870 hypothetical protein LOC57648 [Homo sapiens]
          Length = 1094

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 82/344 (23%), Positives = 110/344 (31%), Gaps = 74/344 (21%)

Query: 119 ARRPGAGPPKAESGQEPASRGQGQSQ-------GQSQGPGSGDTYRPKRPTTLNLFPQVP 171
           +RRP   P +  S     S   G          G    PG     +P+R T+L    + P
Sbjct: 567 SRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPKPERVTSL----RSP 622

Query: 172 RSQDTLNNNSLGKKHSWQDRVSRSS----SPLKTGEQTPPHEHICLSDELPPQSGPAPTT 227
            +  + +  SL    S      RS     +PL      PPH  +      P    P P+ 
Sbjct: 623 GASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKV------PAPFSPPPSK 676

Query: 228 DRGTSTDSPCRRSTATQMAPPGGPPAAPPGGRGHSHRDRIHYQADVRLEATEEIYLTPVQ 287
            R  +  +P   + A    P     A+P                      T +  LTP+Q
Sbjct: 677 PRSPNPAAPALAAPAVVPGPVSTTDASPQS------------------PPTPQTTLTPLQ 718

Query: 288 RPPDAAEPTSAFLPPTESRMSVSSDPDPAAYPSTAGRPHPSISEEEEGFDCLSSPERAEP 347
             P  ++  S   PP+         P P+ +P     P P   + E   +  S+ E AE 
Sbjct: 719 ESPVISKDQSP--PPS---------PPPSYHP-----PPPPTKKPEVVVEAPSASETAEE 762

Query: 348 P--GGGWRGSLGEPPPPPRASLSSDTSALSYDSVKYTLVVDEHAQLELVSLRPCFGDYSD 405
           P     W      PPPPP A    D S   +          E A   + S  P     S 
Sbjct: 763 PLQDPNW------PPPPPPAPEEQDLSMADFPP-------PEEAFFSVASPEPAGPSGSP 809

Query: 406 ESDSATVYDNCASVSSPYESAIGEEYEEAPRPQPPACLSEDSTP 449
           E     V    AS SS     I       P P PPA     S P
Sbjct: 810 E----LVSSPAASSSSATALQIQPPGSPDPPPAPPAPAPASSAP 849



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 56/238 (23%), Positives = 87/238 (36%), Gaps = 19/238 (7%)

Query: 70  PPRAGLLSAGGGG---AGSRLQAEMLQMDLIDATGDTPGAEDDEEDDDEERAARRPGAGP 126
           PPR     +G  G   A S L+ +  +     A G  P A   ++ +D+ + A+  G G 
Sbjct: 21  PPRRKKSRSGASGLRRAFSWLRGKRRKKKAAGAEGAEPAAPRAKKAEDKAKRAKGKGRGS 80

Query: 127 PKAESGQEPASRGQGQSQGQSQGPGSGDTYRPK-RPTTL-NLFPQVPRSQDTLNNNSLGK 184
            KAE+ +   S G GQ  G +      + + P  RP  L  L  Q      +L +    K
Sbjct: 81  AKAENDKH-LSVGPGQGPGSAVDEHQDNVFFPSGRPPHLEELHTQAQEGLRSLQHQEKQK 139

Query: 185 --KHSWQDRVSRSSSPLKTGEQTPPHEHICLSDELPPQSGPAPTTDRGTSTDSPCRRSTA 242
             K  W    ++S    +TG   P  ++I    +       + T +   S  S   +   
Sbjct: 140 LNKGGWDHGDTQSIQSSRTG---PDEDNISFCSQTTSYVAESSTAEDALSIRSEMIQRKG 196

Query: 243 TQMAPPGGPPAAPPGGRGHSHRDRI------HYQADVRLEATEEIYLTPVQRPPDAAE 294
           +   P    P +   GR    R         H Q ++ L    E   TP  R P A +
Sbjct: 197 STFRPHDSFPKSGKSGRRRRERRSTVLGLPQHVQKELGLRNEREAPGTP--RAPGARD 252



 Score = 32.0 bits (71), Expect = 2.0
 Identities = 20/66 (30%), Positives = 27/66 (40%), Gaps = 9/66 (13%)

Query: 270  QADVRLEATEEIYLTPVQRPPDAAEPTSAFLPPTESRMSVSSDP---------DPAAYPS 320
            QAD++     E+     QRPP A + +    PP   + SV   P         +P   P 
Sbjct: 992  QADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSYPRAEPLTAPP 1051

Query: 321  TAGRPH 326
            T G PH
Sbjct: 1052 TNGLPH 1057


>gi|178557734 microtubule-associated protein tau isoform 6 [Homo
           sapiens]
          Length = 776

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 73/271 (26%), Positives = 103/271 (38%), Gaps = 54/271 (19%)

Query: 98  DATGDTPGAEDDEEDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGPGSGDTYR 157
           +A G + G ED +E D  E + ++P A P      + P  + +  S+ +  G GS D   
Sbjct: 336 EARGPSLG-EDTKEADLPEPSEKQPAAAPRGKPVSRVPQLKARMVSKSKD-GTGSDD--- 390

Query: 158 PKRPTTLNLFPQVPRSQDTLNNNS-LGKKHSWQDRVSRSSSPLKTGEQTPPHEHICLSDE 216
            K+  T         S  TL N   L  KH        SS PL      P    +C    
Sbjct: 391 -KKAKT-----STRSSAKTLKNRPCLSPKHP----TPGSSDPLIQ----PSSPAVCPEPP 436

Query: 217 LPPQSGPAPTTDRGTSTDSPCRRSTA---TQMAPPGGPPAAPPGGRGHSHRDRIHYQADV 273
             P+   + T+  G+S     +   A   T++A P G  AAPPG +G ++  RI      
Sbjct: 437 SSPKHVSSVTSRTGSSGAKEMKLKGADGKTKIATPRG--AAPPGQKGQANATRI------ 488

Query: 274 RLEATEEIYLTPVQRPPDAAEPTSAFLPPTESRMSVSSDPDPAAYPSTAGRPHPSISEEE 333
                      P + PP      +   PP+ +   V   P PA   S  G P    S + 
Sbjct: 489 -----------PAKTPP------APKTPPSSATKQVQRRPPPAGPRSERGEPPK--SGDR 529

Query: 334 EGFDCLSSPERAEPPGGGWRGSLGEPPPPPR 364
            G+   SSP     PG   R +   P PP R
Sbjct: 530 SGY---SSPGSPGTPGSRSR-TPSLPTPPTR 556


>gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax
           homolog 2 [Homo sapiens]
          Length = 1210

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 71/326 (21%), Positives = 117/326 (35%), Gaps = 53/326 (16%)

Query: 109 DEEDDDEERAARRP--GAGPPKA-ESGQEP-----ASRGQGQSQGQSQGPGSGDTYRPKR 160
           D ED D E+   +P   + PP A +S  EP     +S  + +S   S      ++     
Sbjct: 431 DSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSS 490

Query: 161 PTTLNLFPQVPRSQDTLNNNSLGKKHSWQDRVSRSSSPLKTGEQT-PPHEHICLSDELPP 219
            +  N   + P  +      +  +  +W  +VS+ ++P +    T PP  H     E   
Sbjct: 491 DSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRRH----PESKG 546

Query: 220 QSGPAPTTDRGTSTDSPCRRSTATQMAPPGGPPAAPPGGRGHSHRDRIHYQADVRLEATE 279
            S  A + +   S D P + S+      P  PP AP  G+    +     +   R     
Sbjct: 547 SSDSATSQEHSESKDPPPKSSSKA----PRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGT 602

Query: 280 EIYLTPVQR-------------------PPDAAEPTSAFLPPTES----RMSVSSDPDPA 316
           +    PV+                    P  + + TS   P  ++    R + S++P PA
Sbjct: 603 KQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPA 662

Query: 317 AYPSTAGRPHPSISEEEEGFDCLSSPERAE------PPGGGWRGSLGEPPPPPRASLSSD 370
             PS+  + H S          LS PE A+       P       L E   PP +   S 
Sbjct: 663 VPPSSEKKKHKSSLPAPS--KALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHSGSGSR 720

Query: 371 TSALSYDSVKYTLVVDEHAQLELVSL 396
           TS       +  +VV E ++ + + L
Sbjct: 721 TS-----GCRQAVVVQEDSRKDRLPL 741



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 56/229 (24%), Positives = 78/229 (34%), Gaps = 51/229 (22%)

Query: 169 QVPRSQDTLNNNSLGKKHSWQDRVSRSSSPLKTGEQTPPHEHICLSDELPPQSGPAP--- 225
           Q   S  T +N+  G     +D +  S S     EQTP       +    PQS P P   
Sbjct: 404 QYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVAS 463

Query: 226 ----------TTDRGTSTDSPCRRSTATQ-----MAPPGGPPAAPPGGRGHSHRDRIHYQ 270
                     T+D  +S+DS    S++       +  P   P  P   +         +Q
Sbjct: 464 AHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNK---------WQ 514

Query: 271 ADVRLEATEEIYLTPVQRPPDAAEPTSAFLPP-------------TESRMSVSSDPDPAA 317
            D         +LT V +P    E   +  PP             T    S S DP P +
Sbjct: 515 LD--------NWLTKVSQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKS 566

Query: 318 YPSTAGRPHPSISEEEEGFDCLSSPERAEPPGGGWRGSLGEPPPPPRAS 366
             S A R  P      +   C  SP + EPP     G+  +P  P +AS
Sbjct: 567 -SSKAPRAPPEAPHPGKR-SCQKSPAQQEPPQRQTVGT-KQPKKPVKAS 612



 Score = 33.1 bits (74), Expect = 0.92
 Identities = 26/80 (32%), Positives = 40/80 (50%), Gaps = 10/80 (12%)

Query: 183 GKKHSWQDRVSRSSSPLK-----TGEQTPPHEHICLSDELPPQSGPAPTTDRGTSTDSPC 237
           GKKHS + R S SSS L        E+   ++ I L  E+  QS  + ++ + +S   P 
Sbjct: 794 GKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPS 853

Query: 238 R---RSTATQMAPPGGPPAA 254
           R   +S+  +M PP  PP +
Sbjct: 854 RPSSQSSKKEMLPP--PPVS 871


>gi|50511945 cajalin 2 isoform a [Homo sapiens]
          Length = 1248

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 58/277 (20%), Positives = 118/277 (42%), Gaps = 35/277 (12%)

Query: 425  SAIGEEYEEAPRPQPPACLSEDSTPDEPDVHFSKKFLNVFMSGRSRSSSAESFGLFSCII 484
            +++G+   + P  +PP  +    T  EP  + +   L+  +S +S  ++  S  +   I+
Sbjct: 941  ASLGDRLHDDPPQKPPRSI----TLREPSGNHTPPQLSPSLS-QSTYTTGGSLDVPHIIM 995

Query: 485  NGEEQEQTHRAIFRFVPRHEDELELEVDDPLLVELQAEDYWYEAYNMR--TGARGVFPAY 542
             G+ + + +   F  +PR + E ++          Q  D+   +  +R    A    P  
Sbjct: 996  QGDARRRRNENYFDDIPRSKLERQMA---------QTGDWGEPSITLRPPNEATASTPVQ 1046

Query: 543  YAIEVTKEPEHMAALAKNSDWVDQFRVKFLGSVQVPYHKGNDVLCAAMQKI-ATTRRLTV 601
            Y       PE +  + ++ D    ++  +LGS+ +   +G +    A  K+ A  ++ T 
Sbjct: 1047 YW---QHHPEKL--IFQSCD----YKAFYLGSMLIKELRGTESTQDACAKMRANCQKSTE 1097

Query: 602  HFNPPSSCVLEISVRGVKIGVKADDSQEAKGNKCSHFFQLKNISFCGYHPKNNKYFGFIT 661
                  + +L +S +GVK         +A         +++NIS     P++   F +IT
Sbjct: 1098 QMKKVPTIILSVSYKGVKF-------IDATNKNIIAEHEIRNISCAAQDPEDLSTFAYIT 1150

Query: 662  KHPADHRFACHVFVSEDSTKA--LAESVGRAFQQFYK 696
            K    +   CHVF + D   A  +  ++G+AF+  Y+
Sbjct: 1151 KDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVAYQ 1187


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
           sapiens]
          Length = 816

 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 70/288 (24%), Positives = 96/288 (33%), Gaps = 28/288 (9%)

Query: 106 AEDDEEDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGPG-SGDTYRPKRPTTL 164
           A +    +    A RRP AG       Q PASR    S      P  SG + R       
Sbjct: 203 ASEHSTTEPSPAARRRPSAGGGL----QRPASRSLSSSATPLSSPARSGPSARGTPRAPA 258

Query: 165 NLFPQVPRSQDTLNNNSLG--KKHSWQDRVSRSSSPLKT-GEQTPPHEHICLSDELPPQS 221
           +     P+    L    +   +K +       SSSPL T     PP      S +  P  
Sbjct: 259 HPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSP 318

Query: 222 GPAPTTDRGTSTDSPCRRSTATQMA----------PPGGPPA-------APPGGRGHSHR 264
              P +   TS  SP  ++T + +           PP  PPA       APP        
Sbjct: 319 PATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPL 378

Query: 265 DRIHYQADVRLEATEEIYLTPVQRPPDAAEPTSAFLPPTESRMSVSSDPDPAAYPSTAGR 324
             +   +     A     L     PP +    + F PP    +S S+ P   A PS A  
Sbjct: 379 SPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAP 438

Query: 325 P---HPSISEEEEGFDCLSSPERAEPPGGGWRGSLGEPPPPPRASLSS 369
           P    PS           + P +A PP       L +PPP    +L++
Sbjct: 439 PLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALAT 486



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 56/208 (26%), Positives = 74/208 (35%), Gaps = 33/208 (15%)

Query: 197 SPLKTGEQTPPHE---HICLSDELPPQSGPA------PTTDRGTSTDSPCRRSTATQMAP 247
           SPL T     P+    H+  +   PP S P       P +   + + +P  ++  +  AP
Sbjct: 379 SPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAP 438

Query: 248 PGGPPAAPPGGRGHSHRDRIHYQADVRLEATE-EIYLTPVQRPPDAAEPT---------- 296
           P   P +PP     S       QA   L A   ++   P Q PP  A P           
Sbjct: 439 PLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPAS 498

Query: 297 ----SAFLPPTESRMSVSSDPDPAAYPSTAGRPHPSISEEEEGFDCLSSPERAEPPG--- 349
               + F P     MS  + P P A P  A  P   +         L +P R   PG   
Sbjct: 499 FPGQAPFSPSASLPMSPLATPPPQAPPVLAA-PLLQVPPSPPASPTLQAPRRPPTPGPDT 557

Query: 350 --GGWRGSLG---EPPPPPRASLSSDTS 372
              G R +L     PPPPP  S SS  S
Sbjct: 558 SVSGPRLTLALAPGPPPPPSRSPSSTLS 585



 Score = 34.3 bits (77), Expect = 0.41
 Identities = 67/292 (22%), Positives = 100/292 (34%), Gaps = 38/292 (13%)

Query: 116 ERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGPGSGDTYRPKRPTTLNLFPQVPRSQD 175
           ERA    GA  P      E A R       +    G G+   P + T+        R+  
Sbjct: 60  ERAGGIGGATIP------ESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASG 113

Query: 176 TLNNNSLGKKHSWQDRVSRSSSPLKTGEQTPPHEHICLSDELPPQSGPAPTTDRGTSTDS 235
           T     LG+K     R+S   +  +      P      +      SGP P    GT + +
Sbjct: 114 TTRPGPLGQKGL---RISAEETVARGKATEAPKRSALSAGARRDTSGPTP----GTPSPA 166

Query: 236 PCRRSTA--TQMAPPGGPPAAPPGGRGHSHRDRIHYQAD-VRLEATEEIYLTP-----VQ 287
             RRS A  T++  P   P+A P       R  +   ++    E +      P     +Q
Sbjct: 167 MARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQ 226

Query: 288 RPPDAAEPTSA--FLPPTESRMSVSSDPDPAAYPST-------AGRPHPSISEEEEGFDC 338
           RP   +  +SA     P  S  S    P   A+PS        A RP       ++    
Sbjct: 227 RPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPA 286

Query: 339 L--------SSPERAEPPGGGWRGSLGEPPPPPRASLSSDTSALSYDSVKYT 382
           L        ++P  + PP      SL   P PP    S  T++L   +++ T
Sbjct: 287 LGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQAT 338


>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
          Length = 2752

 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 42/167 (25%), Positives = 67/167 (40%), Gaps = 16/167 (9%)

Query: 112  DDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGPGSGDTYRPK------------ 159
            D   E  A  P A P ++ SG   +S+G+G S   S    S   + PK            
Sbjct: 1619 DSSPEPKAPAPRALPRRSRSGS--SSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSP 1676

Query: 160  RPTTLNLFPQVPRSQDTLNNNSLGKKHSWQDRVSRSSSPLKTGEQTPPHEHICLSDELPP 219
             P T +  P  PR + + ++  L +K     R   +SS  +T  +TPP      S   P 
Sbjct: 1677 EPKTKSRTP--PRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPE 1734

Query: 220  QSGPAPTTDRGTSTDSPCRRSTATQMAPPGGPPAAPPGGRGHSHRDR 266
             +  + ++ R  S  SP  ++T+ +   P   P      R  S R++
Sbjct: 1735 PAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREK 1781



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 46/180 (25%), Positives = 69/180 (38%), Gaps = 16/180 (8%)

Query: 99  ATGDTPGAEDDEEDDDEERAARRPGAGPPKAESGQEP-------ASRGQGQSQGQSQGPG 151
           AT       +D++ D +E++A RP   P ++ +G EP       A R  G  Q  +  P 
Sbjct: 327 ATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPL 386

Query: 152 SGDTYRP---KRPTTLNLFPQVPRSQDTLNNNSLGKKHSWQDRVSR--SSSPLKTGEQTP 206
           S +   P     PT     P+ P      +++          +VSR  SSSP        
Sbjct: 387 SQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPA 446

Query: 207 PHEHICLSDELPPQSGPAPTTDRGTS-TDSPCR---RSTATQMAPPGGPPAAPPGGRGHS 262
           P  H  +S     ++       R  S + +P R   RS +   A  G   +  P  RGHS
Sbjct: 447 PGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHS 506



 Score = 37.7 bits (86), Expect = 0.037
 Identities = 39/160 (24%), Positives = 49/160 (30%), Gaps = 11/160 (6%)

Query: 108 DDEEDDDEERAARRPGAGPPK----AESGQEPASRGQGQSQGQSQGPGSGDTYRPKRPTT 163
           D     D  R+  R  A        A     PAS  +G+       PG+  T RP  P T
Sbjct: 267 DSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPET 326

Query: 164 LNLFPQVPRSQDTLNNNSLGKKHSWQDRVSRSSSPLKTGEQTPPHEHICLSDELPPQSGP 223
               P  P       +    KK     R S S     TG + PP     L++       P
Sbjct: 327 ATKQPSSP-----YEDKDKDKKEKSATRPSPSPERSSTGPE-PPAPTPLLAERHGGSPQP 380

Query: 224 APTTDRGTS-TDSPCRRSTATQMAPPGGPPAAPPGGRGHS 262
             TT       + P   S     +PP  P   P      S
Sbjct: 381 LATTPLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSES 420



 Score = 35.4 bits (80), Expect = 0.18
 Identities = 47/220 (21%), Positives = 87/220 (39%), Gaps = 16/220 (7%)

Query: 110  EEDDDEERAARRPGAGPPKAESGQE----PASRGQGQSQGQSQGPGSGDTYRPKRPTTLN 165
            E   D++  AR P     ++ S QE    P++  Q +S+  S       T  P R  + +
Sbjct: 1520 ESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQERSESDSSPDSKAKTRTPLRQRSRS 1579

Query: 166  -LFPQVP-RSQDTLNNNSLGKKHSWQDRVSRSSSPLKTGEQTPPHEHICLSDELPPQS-- 221
               P+V  +S+ +   +  G     +D+  R++   ++G  + P         LP +S  
Sbjct: 1580 GSSPEVDSKSRLSPRRSRSGSSPEVKDK-PRAAPRAQSGSDSSPEPKAPAPRALPRRSRS 1638

Query: 222  -----GPAPTTDRGTSTDSPCRRSTATQMAPPGGPPAAPPGGRGHSHRDRIHYQADVRLE 276
                 G  P+ +  +ST+S       ++ A  G   +  P  +  +   R   ++   L 
Sbjct: 1639 GSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPEL- 1697

Query: 277  ATEEIYLTPVQRPPDAAEPTSAFLPPTESRMSVSSDPDPA 316
             T +  L+   R   ++  T +  PP   R    S P+PA
Sbjct: 1698 -TRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPA 1736



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 65/311 (20%), Positives = 102/311 (32%), Gaps = 19/311 (6%)

Query: 168  PQVPRSQDTLNNNSLGKKHSWQDRVSRSSSPLKTGEQTPPHEHICLSD-ELPPQSGPAPT 226
            PQ P S + +   S           SR+++ L     T       LS   L     P   
Sbjct: 2330 PQAPASANLVGPRSAHATAPVNIAGSRTAAALAPASLTSARMAPALSGANLTSPRVPLSA 2389

Query: 227  TDRGTSTDSPCRRSTATQMAPPGGPPAAPPGGRGHSHRDRIHYQADVRLEATEEIYLTPV 286
             +R +   SP     A    PP  P       +     +R    +    +A  +  L P 
Sbjct: 2390 YERVSGRTSPPLLDRARSRTPPSAP------SQSRMTSERAPSPSSRMGQAPSQSLLPPA 2443

Query: 287  QRPPDAAEPTSAFLPPTESRMSVSSDPDPAAYPS-TAGRPHPSISEEEEGFDCLSSPERA 345
            Q  P +  P SAF    +SR  ++     A   S ++G    + S   +    LS P   
Sbjct: 2444 QDQPRSPVP-SAF--SDQSRCLIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPG 2500

Query: 346  EPPGGGWRGSLGEPPPPPRASLSSDTSALSYDSVKYTLVVDEHAQLELVSLRPCFGDYSD 405
             P        +GEPP    A   S  +AL     + +      +     S        S 
Sbjct: 2501 VP-----HSDVGEPPASTGAQQPSALAALQPAKERRS---SSSSSSSSSSSSSSSSSSSS 2552

Query: 406  ESDSATVYDNCASVSSPYESAIGEEYEEAPRPQPPACLSEDSTPDEPDVHFSKKFLNVFM 465
             S S +   +    S P +  +  +   +P P P   + E   P+       ++  +   
Sbjct: 2553 SSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSS 2612

Query: 466  SGRSRSSSAES 476
            S  S SSS+ S
Sbjct: 2613 SSSSSSSSSSS 2623



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 34/188 (18%), Positives = 63/188 (33%), Gaps = 12/188 (6%)

Query: 118  AARRPGAGPPKAESGQEPASRGQGQSQGQSQGPGSGDTYRPKRPTTLNLFPQV------- 170
            AA +P      + S    +S     S   S    SG +      ++L + P+V       
Sbjct: 2522 AALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPS 2581

Query: 171  --PRSQDTLNNNSLGKKHSWQDRVSRSSSPLKTGEQTPPHEHICLSDELPPQSGPAPTTD 228
              P  ++ +      +    + +   SSS   +   +        S      S  + ++ 
Sbjct: 2582 PTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2641

Query: 229  RGTSTDSPCRRSTATQMAPPGGPPAAPPGGRGHSHRDRIHYQADVRLEATEEIYLTPVQR 288
              +S+ SP       Q  P    P  PP G   S   R    +   L  +  +  +PV+R
Sbjct: 2642 SSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDS---LRDSRSLSYSPVER 2698

Query: 289  PPDAAEPT 296
               + +P+
Sbjct: 2699 RRPSPQPS 2706


>gi|237757326 synaptojanin 1 isoform d [Homo sapiens]
          Length = 1526

 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 69/301 (22%), Positives = 98/301 (32%), Gaps = 45/301 (14%)

Query: 97   IDATGDTPGAEDDEEDDDEERAAR--RPGAGPPKAESGQEPASRGQGQSQGQSQGPGSGD 154
            + A  D  G  DD   + EE   +  +P +      S          QS   S+GP    
Sbjct: 1000 VAADFDMEGDVDDYSAEVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSL 1059

Query: 155  TYRPKRPTTLNLFPQVPRSQ--DTLNNNSLGKKHSWQDRVSRSSSPLKTGEQTPPHEHIC 212
              RP R  +    P   +S   D      L +K   Q        PL+     PP     
Sbjct: 1060 PIRPSRAPSRTPGPPSAQSSPIDAQPATPLPQKDPAQ--------PLEPKRPPPPRPVAP 1111

Query: 213  LSDELPPQSGPAPT------TDRGTSTDSPCRRSTATQMAPPGGPPAAPPGGRGHSHRDR 266
             +   PPQ  P P+         G +   P   STA    PP     + P     +   R
Sbjct: 1112 PTRPAPPQRPPPPSGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARASAGR 1171

Query: 267  IHYQADVRLEATEE-IYLTPVQRPPDAAEPTSAFLPPTESRMSVSSDPDPAAYPSTAGRP 325
            +  ++  +   T +     P    P AA P  + LPP   R+     P  A  P +   P
Sbjct: 1172 LTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSG--P 1229

Query: 326  HPSISEEEEGFDCLSSPERAEPPGGGWRGSLGEPPPPPRASLSSDTSALSYDSVKYTLVV 385
             P++                 PP         +PPP  R+S S  + A S   VK   + 
Sbjct: 1230 QPNLE---------------TPP---------QPPPRSRSSHSLPSEASSQPQVKTNGIS 1265

Query: 386  D 386
            D
Sbjct: 1266 D 1266


>gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo
           sapiens]
          Length = 671

 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 21/55 (38%), Positives = 32/55 (58%)

Query: 493 HRAIFRFVPRHEDELELEVDDPLLVELQAEDYWYEAYNMRTGARGVFPAYYAIEV 547
           +RA++++ P++EDELEL   D + V  Q +D W+   + RT   G FP  Y   V
Sbjct: 617 YRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 671



 Score = 33.5 bits (75), Expect = 0.70
 Identities = 16/48 (33%), Positives = 27/48 (56%), Gaps = 1/48 (2%)

Query: 504 EDELELEVDDPLLVELQAEDYWYEAYNMRTGARGVFPAYYAIEVTKEP 551
           E EL     + + +  +  + WYE     TG +G+FPA Y ++V++EP
Sbjct: 470 EVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASY-VQVSREP 516


>gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo
           sapiens]
          Length = 329

 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 21/55 (38%), Positives = 32/55 (58%)

Query: 493 HRAIFRFVPRHEDELELEVDDPLLVELQAEDYWYEAYNMRTGARGVFPAYYAIEV 547
           +RA++++ P++EDELEL   D + V  Q +D W+   + RT   G FP  Y   V
Sbjct: 275 YRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329



 Score = 33.5 bits (75), Expect = 0.70
 Identities = 16/48 (33%), Positives = 27/48 (56%), Gaps = 1/48 (2%)

Query: 504 EDELELEVDDPLLVELQAEDYWYEAYNMRTGARGVFPAYYAIEVTKEP 551
           E EL     + + +  +  + WYE     TG +G+FPA Y ++V++EP
Sbjct: 128 EVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASY-VQVSREP 174


>gi|194473700 Src homology 3 domain-containing guanine nucleotide
           exchange factor [Homo sapiens]
          Length = 871

 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 21/50 (42%), Positives = 28/50 (56%)

Query: 499 FVPRHEDELELEVDDPLLVELQAEDYWYEAYNMRTGARGVFPAYYAIEVT 548
           F  +  DEL L+V D +L+  +  D WYE   +R G RG FP   A E+T
Sbjct: 800 FTAKQPDELSLQVADVVLIYQRVSDGWYEGERLRDGERGWFPMECAKEIT 849


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 61/287 (21%), Positives = 92/287 (32%), Gaps = 36/287 (12%)

Query: 98  DATGDTPGAEDDEEDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGPGSGDTYR 157
           D +G TPG            A R   AG         P++R +  ++G  +   S   + 
Sbjct: 163 DTSGPTPGTPSPA------MARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHS 216

Query: 158 PKRPTTLNLFPQVPRSQDTLNNNSLGKKHSWQDRVSRSSSPLKTGEQTPPHEHICLSDEL 217
              P+     P   R              S     +  SSP ++G   P       +   
Sbjct: 217 TTEPS-----PAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG---PSARGTPRAPAH 268

Query: 218 PPQSGPAPTTDRGTSTDSPCRRSTATQMAPPGGPPAAPPGGRGHSHRDRIHYQADVRLEA 277
           P Q  P           +P R+  A  + P    P A P   G   R             
Sbjct: 269 PSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKAR------------- 315

Query: 278 TEEIYLTPVQRPPDAAEPTSAFLPPTESRMSVS--SDPDPAAYPSTAGRPHPSISEEEEG 335
                  PV  P +AA P  A LPP+    +    + P P+A PS    P P  +   + 
Sbjct: 316 -------PVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQA 368

Query: 336 FDCLSSPERAEPPGGGWRGSLGEPPPPPRASLSSDTSALSYDSVKYT 382
              +++P    PP       +  P      SL +  S L+  S++ T
Sbjct: 369 PPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQAT 415



 Score = 36.6 bits (83), Expect = 0.083
 Identities = 46/169 (27%), Positives = 56/169 (33%), Gaps = 14/169 (8%)

Query: 205 TPPHEHICLSDELPPQSGPAPTTDRGTSTDSPCRRSTATQMAPPGGPPA-------APPG 257
           TPP E        PPQ+ PA  +       SP     AT   PP  PP        APP 
Sbjct: 578 TPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATP--PPQAPPXLALPPLQAPPS 635

Query: 258 GRGHSHRDRIHYQADVRLEATEEIYLTPVQRPPDAAEPTSAFLPPTESRMSVSSDPDPAA 317
                    +   +     A     L     PP +    + F PP    +S S+ P   A
Sbjct: 636 PPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQA 695

Query: 318 YPSTAGRP---HPSISEEEEGFDCLSSPERAEPPGGGWRGSLGEPPPPP 363
            PS A  P    PS           + P +A PP       L  PP PP
Sbjct: 696 PPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAA--PPLQVPPSPP 742



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 68/276 (24%), Positives = 88/276 (31%), Gaps = 39/276 (14%)

Query: 197 SPLKTGEQTPPHE---HICLSDELPPQSGPA------PTTDRGTSTDSPCRRSTATQMAP 247
           SPL T     P+    H+  +   PP S P       P +   + + +P  ++  +  AP
Sbjct: 643 SPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAP 702

Query: 248 PGGPPAAPPGGRGHSHRDRIHYQADVRLEATEEIYLTPVQRPPDAAEPTSAFLPPTESRM 307
           P   P +PP     S       QA   L A       P+Q PP          PP    M
Sbjct: 703 PLQVPPSPPASPPMSPSATPPPQAPPPLAAP------PLQVPPS---------PPASPPM 747

Query: 308 SVSSDPDPAAYPSTAGRP--HPSISEEEEGFDCLSSPERAEPPGGGWRGSLGEPP----P 361
           S S+ P P   P  A  P   P           L+ P    PP      +L  PP    P
Sbjct: 748 SPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPP------ALATPPLQALP 801

Query: 362 PPRASLSSDTSALSYDSVKYTLVVDEHAQLELVSLRPCFGDYSDESDSATVY-DNCASVS 420
            P AS           S+  + +     Q   V   P          S T+         
Sbjct: 802 SPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTP 861

Query: 421 SPYESAIGEE--YEEAPRPQPPACLSEDSTPDEPDV 454
            P  S  G       AP P PP   S  ST   PD+
Sbjct: 862 GPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDL 897


>gi|67514036 SH3-domain kinase binding protein 1 isoform b [Homo
           sapiens]
          Length = 628

 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 21/69 (30%), Positives = 42/69 (60%), Gaps = 2/69 (2%)

Query: 486 GEEQEQTHRAIFRFVPRHEDELELEVDDPLLVELQAEDYWYEAYNMRTGARGVFPAYYAI 545
           GE + +  +  F ++P+++DELEL+V D + V  + E+ W+E   +  G  G+FP+ +  
Sbjct: 59  GERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWE--GVLNGKTGMFPSNFIK 116

Query: 546 EVTKEPEHM 554
           E++ E + +
Sbjct: 117 ELSGESDEL 125


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.312    0.131    0.395 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,956,029
Number of Sequences: 37866
Number of extensions: 2127004
Number of successful extensions: 14081
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 98
Number of HSP's successfully gapped in prelim test: 733
Number of HSP's that attempted gapping in prelim test: 11560
Number of HSP's gapped (non-prelim): 2768
length of query: 711
length of database: 18,247,518
effective HSP length: 109
effective length of query: 602
effective length of database: 14,120,124
effective search space: 8500314648
effective search space used: 8500314648
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.