BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|4885407 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 [Homo sapiens] (1203 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|4885407 hyperpolarization activated cyclic nucleotide-gated p... 2429 0.0 gi|156071470 hyperpolarization activated cyclic nucleotide-gated... 1068 0.0 gi|116325989 hyperpolarization activated cyclic nucleotide-gated... 1005 0.0 gi|38327037 hyperpolarization activated cyclic nucleotide-gated ... 962 0.0 gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2 [... 191 3e-48 gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Ho... 190 8e-48 gi|13540549 potassium voltage-gated channel, subfamily H, member... 186 2e-46 gi|27886653 potassium voltage-gated channel, subfamily H, member... 178 3e-44 gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1 [... 175 2e-43 gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [H... 175 2e-43 gi|26051273 voltage-gated potassium channel, subfamily H, member... 174 3e-43 gi|4557729 voltage-gated potassium channel, subfamily H, member ... 174 3e-43 gi|4504831 potassium voltage-gated channel, subfamily H, member ... 173 8e-43 gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens] 171 4e-42 gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens] 170 7e-42 gi|22024390 potassium voltage-gated channel, subfamily H, member... 170 9e-42 gi|27886648 potassium voltage-gated channel, subfamily H, member... 170 9e-42 gi|27886651 potassium voltage-gated channel, subfamily H, member... 170 9e-42 gi|6912446 potassium voltage-gated channel, subfamily H, member ... 165 2e-40 gi|27437001 potassium voltage-gated channel, subfamily H, member... 165 3e-40 gi|27886667 potassium voltage-gated channel, subfamily H, member... 159 2e-38 gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [H... 156 1e-37 gi|38569493 potassium voltage-gated channel, subfamily H (eag-re... 153 8e-37 gi|26051271 voltage-gated potassium channel, subfamily H, member... 152 2e-36 gi|27886646 potassium voltage-gated channel, subfamily H, member... 150 7e-36 gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens] 140 9e-33 gi|27886665 potassium voltage-gated channel, subfamily H, member... 136 1e-31 gi|163965366 nascent polypeptide-associated complex alpha subuni... 93 2e-18 gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens] 86 3e-16 gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 82 3e-15 >gi|4885407 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 [Homo sapiens] Length = 1203 Score = 2429 bits (6295), Expect = 0.0 Identities = 1203/1203 (100%), Positives = 1203/1203 (100%) Query: 1 MDKLPPSMRKRLYSLPQQVGAKAWIMDEEEDAEEEGAGGRQDPSRRSIRLRPLPSPSPSA 60 MDKLPPSMRKRLYSLPQQVGAKAWIMDEEEDAEEEGAGGRQDPSRRSIRLRPLPSPSPSA Sbjct: 1 MDKLPPSMRKRLYSLPQQVGAKAWIMDEEEDAEEEGAGGRQDPSRRSIRLRPLPSPSPSA 60 Query: 61 AAGGTESRSSALGAADSEGPARGAGKSSTNGDCRRFRGSLASLGSRGGGSGGTGSGSSHG 120 AAGGTESRSSALGAADSEGPARGAGKSSTNGDCRRFRGSLASLGSRGGGSGGTGSGSSHG Sbjct: 61 AAGGTESRSSALGAADSEGPARGAGKSSTNGDCRRFRGSLASLGSRGGGSGGTGSGSSHG 120 Query: 121 HLHDSAEERRLIAEGDASPGEDRTPPGLAAEPERPGASAQPAASPPPPQQPPQPASASCE 180 HLHDSAEERRLIAEGDASPGEDRTPPGLAAEPERPGASAQPAASPPPPQQPPQPASASCE Sbjct: 121 HLHDSAEERRLIAEGDASPGEDRTPPGLAAEPERPGASAQPAASPPPPQQPPQPASASCE 180 Query: 181 QPSVDTAIKVEGGAAAGDQILPEAEVRLGQAGFMQRQFGAMLQPGVNKFSLRMFGSQKAV 240 QPSVDTAIKVEGGAAAGDQILPEAEVRLGQAGFMQRQFGAMLQPGVNKFSLRMFGSQKAV Sbjct: 181 QPSVDTAIKVEGGAAAGDQILPEAEVRLGQAGFMQRQFGAMLQPGVNKFSLRMFGSQKAV 240 Query: 241 EREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNV 300 EREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNV Sbjct: 241 EREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNV 300 Query: 301 VSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVE 360 VSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVE Sbjct: 301 VSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVE 360 Query: 361 TRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVN 420 TRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVN Sbjct: 361 TRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVN 420 Query: 421 LIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMVNNSWGKQYSYALFKAMSHMLCIG 480 LIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMVNNSWGKQYSYALFKAMSHMLCIG Sbjct: 421 LIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMVNNSWGKQYSYALFKAMSHMLCIG 480 Query: 481 YGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSF 540 YGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSF Sbjct: 481 YGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSF 540 Query: 541 HKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANAD 600 HKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANAD Sbjct: 541 HKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANAD 600 Query: 601 PNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGE 660 PNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGE Sbjct: 601 PNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGE 660 Query: 661 ICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKNSI 720 ICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKNSI Sbjct: 661 ICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKNSI 720 Query: 721 LLHKVQHDLNSGVFNYQENEIIQQIVQHDREMAHCAHRVQAAASATPTPTPVIWTPLIQA 780 LLHKVQHDLNSGVFNYQENEIIQQIVQHDREMAHCAHRVQAAASATPTPTPVIWTPLIQA Sbjct: 721 LLHKVQHDLNSGVFNYQENEIIQQIVQHDREMAHCAHRVQAAASATPTPTPVIWTPLIQA 780 Query: 781 PLQAAAATTSVAIALTHHPRLPAAIFRPPPGSGLGNLGAGQTPRHLKRLQSLIPSALGSA 840 PLQAAAATTSVAIALTHHPRLPAAIFRPPPGSGLGNLGAGQTPRHLKRLQSLIPSALGSA Sbjct: 781 PLQAAAATTSVAIALTHHPRLPAAIFRPPPGSGLGNLGAGQTPRHLKRLQSLIPSALGSA 840 Query: 841 SPASSPSQVDTPSSSSFHIQQLAGFSAPAGLSPLLPSSSSSPPPGACGSPSAPTPSAGVA 900 SPASSPSQVDTPSSSSFHIQQLAGFSAPAGLSPLLPSSSSSPPPGACGSPSAPTPSAGVA Sbjct: 841 SPASSPSQVDTPSSSSFHIQQLAGFSAPAGLSPLLPSSSSSPPPGACGSPSAPTPSAGVA 900 Query: 901 ATTIAGFGHFHKALGGSLSSSDSPLLTPLQPGARSPQAAQPSPAPPGARGGLGLPEHFLP 960 ATTIAGFGHFHKALGGSLSSSDSPLLTPLQPGARSPQAAQPSPAPPGARGGLGLPEHFLP Sbjct: 901 ATTIAGFGHFHKALGGSLSSSDSPLLTPLQPGARSPQAAQPSPAPPGARGGLGLPEHFLP 960 Query: 961 PPPSSRSPSSSPGQLGQPPGELSLGLATGPLSTPETPPRQPEPPSLVAGASGGASPVGFT 1020 PPPSSRSPSSSPGQLGQPPGELSLGLATGPLSTPETPPRQPEPPSLVAGASGGASPVGFT Sbjct: 961 PPPSSRSPSSSPGQLGQPPGELSLGLATGPLSTPETPPRQPEPPSLVAGASGGASPVGFT 1020 Query: 1021 PRGGLSPPGHSPGPPRTFPSAPPRASGSHGSLLLPPASSPPPPQVPQRRGTPPLTPGRLT 1080 PRGGLSPPGHSPGPPRTFPSAPPRASGSHGSLLLPPASSPPPPQVPQRRGTPPLTPGRLT Sbjct: 1021 PRGGLSPPGHSPGPPRTFPSAPPRASGSHGSLLLPPASSPPPPQVPQRRGTPPLTPGRLT 1080 Query: 1081 QDLKLISASQPALPQDGAQTLRRASPHSSGESMAAFPLFPRAGGGSGGSGSSGGLGPPGR 1140 QDLKLISASQPALPQDGAQTLRRASPHSSGESMAAFPLFPRAGGGSGGSGSSGGLGPPGR Sbjct: 1081 QDLKLISASQPALPQDGAQTLRRASPHSSGESMAAFPLFPRAGGGSGGSGSSGGLGPPGR 1140 Query: 1141 PYGAIPGQHVTLPRKTSSGSLPPPLSLFGARATSSGGPPLTAGPQREPGARPEPVRSKLP 1200 PYGAIPGQHVTLPRKTSSGSLPPPLSLFGARATSSGGPPLTAGPQREPGARPEPVRSKLP Sbjct: 1141 PYGAIPGQHVTLPRKTSSGSLPPPLSLFGARATSSGGPPLTAGPQREPGARPEPVRSKLP 1200 Query: 1201 SNL 1203 SNL Sbjct: 1201 SNL 1203 >gi|156071470 hyperpolarization activated cyclic nucleotide-gated potassium channel 2 [Homo sapiens] Length = 889 Score = 1068 bits (2762), Expect = 0.0 Identities = 598/933 (64%), Positives = 651/933 (69%), Gaps = 99/933 (10%) Query: 52 PLPSPSPSAAAGGTESRSSALG--AADSEGPARGAGKSSTNGDCRRFRGSLASLGSRGGG 109 P P P P A R+ AL AAD GP RG L S S G Sbjct: 41 PAPPPGPGPAPPQHPPRAEALPPEAADEGGP----------------RGRLRSRDSSCGR 84 Query: 110 SGGTGSGSSHGHLHDSAEERRLIAEGDASPGEDRTPPGLAAEPERPGASAQPAASPPPPQ 169 G G+ S+ + G+ GE + P A PE P + + S Sbjct: 85 PGTPGAAST----------AKGSPNGECGRGEPQCSP---AGPEGPARGPKVSFSCRGAA 131 Query: 170 QPPQPASASCEQPSVDTAIKVEGGAAAGDQILPEAEVRLGQAGFMQRQFGAMLQPGVNKF 229 P P E+ A ++ P E R QA FMQRQFGA+LQPGVNKF Sbjct: 132 SGPAPGPGPAEE-------------AGSEEAGPAGEPRGSQASFMQRQFGALLQPGVNKF 178 Query: 230 SLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKD 289 SLRMFGSQKAVEREQERVKSAG WIIHPYSDFRFYWD TMLL MVGNLIIIPVGITFFKD Sbjct: 179 SLRMFGSQKAVEREQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFKD 238 Query: 290 ENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISS 349 E T PWIVFNVVSDTFFL+DLVLNFRTGIV+EDNTEIILDP++IK KYL++WF+VDF+SS Sbjct: 239 ETTAPWIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSS 298 Query: 350 IPVDYIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTY 409 IPVDYIFLIVE IDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTY Sbjct: 299 IPVDYIFLIVEKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTY 358 Query: 410 DLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMVNNSWGKQYSYAL 469 DLASAV+RI NLI MMLLLCHWDGCLQFLVPMLQDFP +CWVSIN MVN+SW + YS+AL Sbjct: 359 DLASAVMRICNLISMMLLLCHWDGCLQFLVPMLQDFPRNCWVSINGMVNHSWSELYSFAL 418 Query: 470 FKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQE 529 FKAMSHMLCIGYGRQAP M+D+WLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQE Sbjct: 419 FKAMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQE 478 Query: 530 KYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKL 589 KYKQVEQYMSFHKLP D RQ+IHDYYEHRYQGKMFDE+SILGEL+ PLREEI+NFNCRKL Sbjct: 479 KYKQVEQYMSFHKLPADFRQKIHDYYEHRYQGKMFDEDSILGELNGPLREEIVNFNCRKL 538 Query: 590 VASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKE 649 VASMPLFANADPNFVT+MLTKL+FEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKE Sbjct: 539 VASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKE 598 Query: 650 TKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALD 709 KL+DGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVA+D Sbjct: 599 MKLSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAID 658 Query: 710 RLDRIGKKNSILLHKVQHDLNSGVFNYQENEIIQQIVQHDREMAHCAHRVQAAASATPTP 769 RLDRIGKKNSILLHKVQHDLNSGVFN QEN IIQ+IV++DREM A Q P P Sbjct: 659 RLDRIGKKNSILLHKVQHDLNSGVFNNQENAIIQEIVKYDREMVQQAELGQRVGLFPPPP 718 Query: 770 TPVIWTPLIQAPLQAAAATTSVAIALTHHPRL----PAAIFRPPPGSGLGNLGAGQTPRH 825 P T I QAAA + +A L P + RPPPG G P Sbjct: 719 PPPQVTSAIATLQQAAAMSFCPQVARPLVGPLALGSPRLVRRPPPGPAPAAASPGPPP-- 776 Query: 826 LKRLQSLIPSALGSASPASSPSQVDTPSSSSFHIQQLAGFSAPAGLSPLLPSS--SSSPP 883 ASP +P+ P +S + G A P LP+ S + Sbjct: 777 -------------PASPPGAPASPRAPRTSPY-----GGLPAAPLAGPALPARRLSRASR 818 Query: 884 PGACGSPSAPTPSAGVAATTIAGFGHFHKALGGSLSSSDSPLLTPLQPGARSPQAAQPSP 943 P + PS P + G AA+T +SS +P L P P AR AA PSP Sbjct: 819 PLSASQPSLPHGAPGPAAST-------------RPASSSTPRLGP-TPAAR---AAAPSP 861 Query: 944 -----APPGARGGLGLPEHFLPPPPSSRSPSSS 971 A PGA GG L P S+RS SS Sbjct: 862 DRRDSASPGAAGG-------LDPQDSARSRLSS 887 Score = 47.4 bits (111), Expect = 8e-05 Identities = 46/139 (33%), Positives = 56/139 (40%), Gaps = 25/139 (17%) Query: 924 PLLTPLQPGA-RSPQAAQPSPAPPGARGGLGLPEHFLPPPPSSRSPSSSPGQLGQPPGEL 982 PL+ PL G+ R + P PAP A G PPPP+S P +P P Sbjct: 745 PLVGPLALGSPRLVRRPPPGPAPAAASPG--------PPPPAS--PPGAPASPRAPRTSP 794 Query: 983 SLGLATGPLSTPETP---------PRQPEPPSLVAGASGGASPV----GFTPRGGLSPPG 1029 GL PL+ P P P PSL GA G A+ TPR G +P Sbjct: 795 YGGLPAAPLAGPALPARRLSRASRPLSASQPSLPHGAPGPAASTRPASSSTPRLGPTPAA 854 Query: 1030 HSPGP-PRTFPSAPPRASG 1047 + P P SA P A+G Sbjct: 855 RAAAPSPDRRDSASPGAAG 873 Score = 46.6 bits (109), Expect = 1e-04 Identities = 55/192 (28%), Positives = 77/192 (40%), Gaps = 27/192 (14%) Query: 952 LGLPEHFLPPPPSSRSPSSSPGQLGQPPGELSLGLATGPLSTPETPPRQPEPPSLVAGAS 1011 LG PPPP PP +++ +AT + + Q P LV + Sbjct: 707 LGQRVGLFPPPP--------------PPPQVTSAIATLQQAAAMSFCPQVARP-LVGPLA 751 Query: 1012 GGASPVGFTPRGGLSPPGHSPGPPRTFPSAPPRASGSHGSLLLPPASSPPPPQVPQRRGT 1071 G+ + P G +P SPGPP P++PP A S + P +SP Sbjct: 752 LGSPRLVRRPPPGPAPAAASPGPPP--PASPPGAPASPRA----PRTSPYGGLPAAPLAG 805 Query: 1072 PPLTPGRLTQDLKLISASQPALPQDGAQTLRRASPHSS-----GESMAAFPLFPRAG-GG 1125 P L RL++ + +SASQP+LP P SS G + AA P Sbjct: 806 PALPARRLSRASRPLSASQPSLPHGAPGPAASTRPASSSTPRLGPTPAARAAAPSPDRRD 865 Query: 1126 SGGSGSSGGLGP 1137 S G++GGL P Sbjct: 866 SASPGAAGGLDP 877 Score = 41.2 bits (95), Expect = 0.006 Identities = 66/263 (25%), Positives = 81/263 (30%), Gaps = 80/263 (30%) Query: 913 ALGGSLSSSDSPLLTPLQPGARSPQAAQPSPAPPGARGGLGLPEHFLPPPPSSRSPSSSP 972 A GG +SP TP PG P P PAPP + PPPP +P P Sbjct: 3 ARGGGGRPGESPGATPA-PGPPPP----PPPAPPQQQ----------PPPPPPPAPPPGP 47 Query: 973 GQLGQPPGELSLGLATGPLSTPETPPRQPEPPSLVAGASGGASPVGFTPRGGLSPPGHSP 1032 G + P+ PPR P A G PRG L S Sbjct: 48 GP-----------------APPQHPPRAEALPPEAADEGG--------PRGRLRSRDSSC 82 Query: 1033 GPPRTFPSAPPRASGSHGSLLLPPASSPPPPQVPQRRGTPPLTPGRLTQDLKLISASQPA 1092 G P T P A A GS P RG P +P + P Sbjct: 83 GRPGT-PGAASTAKGS--------------PNGECGRGEPQCSP------------AGPE 115 Query: 1093 LPQDGAQTLRRASPHSSGESMAAFPLFPRAGGGSGGSGSSGGLGPPGRPYGAIPGQHVTL 1152 P G + +SG P G G S GP G P G+ + Sbjct: 116 GPARGPKVSFSCRGAASG---------PAPGPGPAEEAGSEEAGPAGEPRGS----QASF 162 Query: 1153 PRKTSSGSLPPPLSLFGARATSS 1175 ++ L P ++ F R S Sbjct: 163 MQRQFGALLQPGVNKFSLRMFGS 185 Score = 37.4 bits (85), Expect = 0.087 Identities = 52/176 (29%), Positives = 60/176 (34%), Gaps = 33/176 (18%) Query: 1022 RGGLSPPGHSPGPPRTFPSAPPRASGSHGSLLLPPASSPPPPQVPQRRGTPPLTPGRLTQ 1081 RGG PG SPG P PP PPPP PQ++ PP P Sbjct: 4 RGGGGRPGESPGATPA-PGPPP----------------PPPPAPPQQQPPPPPPPAPPPG 46 Query: 1082 DLKLISASQP---ALPQDGAQTLRRASPHSSGESMAAFPLFPRAGGGSGGS--GSSGGLG 1136 P ALP + A S +S P P A + GS G G Sbjct: 47 PGPAPPQHPPRAEALPPEAADEGGPRGRLRSRDSSCGRPGTPGAASTAKGSPNGECGRGE 106 Query: 1137 P---PGRPYGAIPGQHVTLP-RKTSSGSLPPPLSLFGARATSSGGPPLTAGPQREP 1188 P P P G G V+ R +SG P P A +G AGP EP Sbjct: 107 PQCSPAGPEGPARGPKVSFSCRGAASGPAPGP-----GPAEEAGSE--EAGPAGEP 155 Score = 37.4 bits (85), Expect = 0.087 Identities = 47/153 (30%), Positives = 55/153 (35%), Gaps = 26/153 (16%) Query: 1053 LLPPASSPPPPQVPQRRGTPPLTPGRLTQDLKLISASQPALPQDGAQTLRRASPHSSGES 1112 L PP PPPPQV T L Q + Q A P G L SP Sbjct: 713 LFPPP--PPPPQVTSAIAT-------LQQAAAMSFCPQVARPLVGPLAL--GSPR----- 756 Query: 1113 MAAFPLFPRAGGGSGGSGSSGGLGPPGRPYGAIPGQHVTLPRKTSSGSLPP-PLS--LFG 1169 L R G + +S G PP P GA PR + G LP PL+ Sbjct: 757 -----LVRRPPPGPAPAAASPGPPPPASPPGAPASPRA--PRTSPYGGLPAAPLAGPALP 809 Query: 1170 ARATSSGGPPLTAGPQREPGARPEPVRSKLPSN 1202 AR S PL+A P P P S P++ Sbjct: 810 ARRLSRASRPLSASQPSLPHGAPGPAASTRPAS 842 Score = 33.9 bits (76), Expect = 0.96 Identities = 21/65 (32%), Positives = 23/65 (35%), Gaps = 2/65 (3%) Query: 135 GDASPGED--RTPPGLAAEPERPGASAQPAASPPPPQQPPQPASASCEQPSVDTAIKVEG 192 G PGE TP P P Q PPPP PP P A + P A+ E Sbjct: 6 GGGRPGESPGATPAPGPPPPPPPAPPQQQPPPPPPPAPPPGPGPAPPQHPPRAEALPPEA 65 Query: 193 GAAAG 197 G Sbjct: 66 ADEGG 70 >gi|116325989 hyperpolarization activated cyclic nucleotide-gated potassium channel 1 [Homo sapiens] Length = 890 Score = 1005 bits (2599), Expect = 0.0 Identities = 554/901 (61%), Positives = 627/901 (69%), Gaps = 82/901 (9%) Query: 135 GDASPGEDRTPPGLAAEPERPGAS-AQPAASPPPPQQPPQPASASCEQPSVDTAIKVEGG 193 G + + G + P + A+ A PAA+ PP A ++ KV+GG Sbjct: 5 GKPNSSSNSRDDGNSVFPAKASATGAGPAAAEKRLGTPPGGGGAGAKEHGNSVCFKVDGG 64 Query: 194 AAAGDQI---------LPEAEVRLGQAGFMQRQFGAMLQPGVNKFSLRMFGSQKAVEREQ 244 G +AE Q GFMQRQF +MLQPGVNKFSLRMFGSQKAVE+EQ Sbjct: 65 GGGGGGGGGGEEPAGGFEDAEGPRRQYGFMQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQ 124 Query: 245 ERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNVVSDT 304 ERVK+AGFWIIHPYSDFRFYWDL ML++MVGNL+IIPVGITFF ++ TTPWI+FNV SDT Sbjct: 125 ERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDT 184 Query: 305 FFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVETRID 364 FL+DL++NFRTG V ED++EIILDP+ IKM YLKSWF+VDFISSIPVDYIFLIVE +D Sbjct: 185 VFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGMD 244 Query: 365 SEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGM 424 SEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRI NLIGM Sbjct: 245 SEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGM 304 Query: 425 MLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMVNNSWGKQYSYALFKAMSHMLCIGYGRQ 484 MLLLCHWDGCLQFLVP+LQDFP DCWVS+N MVN+SWGKQYSYALFKAMSHMLCIGYG Q Sbjct: 305 MLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQ 364 Query: 485 APVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLP 544 APV MSD+W+TMLSMIVGATCYAMF+GHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLP Sbjct: 365 APVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLP 424 Query: 545 PDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFV 604 D RQ+IHDYYEHRYQGK+FDEE+IL EL++PLREEI+NFNCRKLVA+MPLFANADPNFV Sbjct: 425 ADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFV 484 Query: 605 TSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICLL 664 T+ML+KLRFEVFQPGDYIIREG +GKKMYFIQHGV V+TK +KE KL DGSYFGEICLL Sbjct: 485 TAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLL 544 Query: 665 TRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKNSILLHK 724 T+GRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVA+DRLDRIGKKNSILL K Sbjct: 545 TKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQK 604 Query: 725 VQHDLNSGVFNYQENEIIQQIVQHDREMAHCAHRVQAAASATPTPTPVIWTPLIQAPLQA 784 Q DLN+GVFN QENEI++QIV+HDREM + T T TP + Q+ Sbjct: 605 FQKDLNTGVFNNQENEILKQIVKHDREMVQAIAPINYPQMTTLNSTSSTTTPTSRMRTQS 664 Query: 785 AAATTSVAIALTHHPRLPAAIFRPPPGSGLGNLGAGQTPRHLKRLQSLIPSALGSASPAS 844 T A +L+H + + P P + QTP+ L + + P Sbjct: 665 PPVYT--ATSLSH-----SNLHSPSPST--------QTPQPSAILSPCSYTTAVCSPPVQ 709 Query: 845 SPSQVDT-----PSSSSFHI-----QQLAGFSAPAGLSPLLPSSSSSPPPGACGSP---- 890 SP T P++S + QQ S P P P SP P GS Sbjct: 710 SPLAARTFHYASPTASQLSLMQQQPQQQVQQSQPPQTQPQQP----SPQPQTPGSSTPKN 765 Query: 891 ---------------------SAPTPSAGVAATTIAGFGHFHKALGGSLSSSDSPLL--- 926 SA PS +T+ H +G SL+S P+ Sbjct: 766 EVHKSTQALHNTNLTREVRPLSASQPSLPHEVSTL--ISRPHPTVGESLASIPQPVTAVP 823 Query: 927 -TPLQPGARS--PQAA-----QPSPAPPGARGGLGLPEHFLPPPPSSRSPSSSPGQLGQP 978 T LQ G RS PQ S A P R G+P PPPP++ P S L Sbjct: 824 GTGLQAGGRSTVPQRVTLFRQMSSGAIPPNR---GVPP--APPPPAAALPRESSSVLNTD 878 Query: 979 P 979 P Sbjct: 879 P 879 Score = 72.4 bits (176), Expect = 2e-12 Identities = 78/265 (29%), Positives = 112/265 (42%), Gaps = 50/265 (18%) Query: 964 SSRSPSSSPGQLGQPPGELSLGLATGPLSTPETPPRQPEPPSLVAGASGGASPVGFTPRG 1023 SS + +S + PP + L+ L +P + P+P +++ SP +T Sbjct: 651 SSTTTPTSRMRTQSPPVYTATSLSHSNLHSPSPSTQTPQPSAIL-------SPCSYTT-A 702 Query: 1024 GLSPPGHSPGPPRTFPSAPPRASGSHGSLLLPPAS---SPPPPQVPQRRGTPPLTPG--- 1077 SPP SP RTF A P AS P S PP PQ+ P TPG Sbjct: 703 VCSPPVQSPLAARTFHYASPTASQLSLMQQQPQQQVQQSQPPQTQPQQPSPQPQTPGSST 762 Query: 1078 ---------------RLTQDLKLISASQPALPQDGAQTLRRASPHSSGESMAAFPLFPRA 1122 LT++++ +SASQP+LP + + + R P + GES+A+ P A Sbjct: 763 PKNEVHKSTQALHNTNLTREVRPLSASQPSLPHEVSTLISRPHP-TVGESLASIPQPVTA 821 Query: 1123 GGGSGGSGSSGGLGPPGRPYGAIPGQHVTLPRKTSSGSLPPPLSLFGARATSSGGPPLTA 1182 G+ GL GR +P Q VTL R+ SSG++PP R PP A Sbjct: 822 VPGT-------GLQAGGR--STVP-QRVTLFRQMSSGAIPP------NRGVPPAPPPPAA 865 Query: 1183 GPQREPGA----RPEPVRSKLPSNL 1203 RE + P+ + + SNL Sbjct: 866 ALPRESSSVLNTDPDAEKPRFASNL 890 >gi|38327037 hyperpolarization activated cyclic nucleotide-gated potassium channel 3 [Homo sapiens] Length = 774 Score = 962 bits (2487), Expect = 0.0 Identities = 520/814 (63%), Positives = 592/814 (72%), Gaps = 61/814 (7%) Query: 142 DRTPPGLAAEPERPGASAQPAASPPPPQQPPQPASASCEQPSVDTAIKVEGGAAAGDQIL 201 ++ P A+E PG A P +PPP P S +P Sbjct: 4 EQRPAAGASEGATPGLEAVPPVAPPPATAASGPIPKSGPEPK------------------ 45 Query: 202 PEAEVRLGQAGFMQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDF 261 +R G +LQP VNKFSLR+FGS KAVE EQERVKSAG WIIHPYSDF Sbjct: 46 -------------RRHLGTLLQPTVNKFSLRVFGSHKAVEIEQERVKSAGAWIIHPYSDF 92 Query: 262 RFYWDLTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVE 321 RFYWDL MLLLMVGNLI++PVGITFFK+EN+ PWIVFNV+SDTFFL+DLVLNFRTGIVVE Sbjct: 93 RFYWDLIMLLLMVGNLIVLPVGITFFKEENSPPWIVFNVLSDTFFLLDLVLNFRTGIVVE 152 Query: 322 DNTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVET--RIDSEVYKTARALRIVRF 379 + EI+L P+ I+ +YL++WF+VD ISSIPVDYIFL+VE R+D+EVYKTARALRIVRF Sbjct: 153 EGAEILLAPRAIRTRYLRTWFLVDLISSIPVDYIFLVVELEPRLDAEVYKTARALRIVRF 212 Query: 380 TKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLV 439 TKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRI NLIGMMLLLCHWDGCLQFLV Sbjct: 213 TKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLV 272 Query: 440 PMLQDFPDDCWVSINNMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSM 499 PMLQDFP DCWVSIN+MVN+SWG+QYS+ALFKAMSHMLCIGYG+QAPVGM DVWLTMLSM Sbjct: 273 PMLQDFPPDCWVSINHMVNHSWGRQYSHALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSM 332 Query: 500 IVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRY 559 IVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLP DTRQRIH+YYEHRY Sbjct: 333 IVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRY 392 Query: 560 QGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPG 619 QGKMFDEESILGELSEPLREEIINF CR LVA MPLFA+ADP+FVT++LTKLRFEVFQPG Sbjct: 393 QGKMFDEESILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPG 452 Query: 620 DYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRADTYC 679 D ++REG++G+KMYFIQHG++SVL +G ++T+L DGSYFGEICLLTRGRRTASVRADTYC Sbjct: 453 DLVVREGSVGRKMYFIQHGLLSVLARGARDTRLTDGSYFGEICLLTRGRRTASVRADTYC 512 Query: 680 RLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKNSILLHKVQHDLNSGVFNYQEN 739 RLYSLSVD+FN VLEE+PMMRRAFETVA+DRL RIGKKNSIL K E Sbjct: 513 RLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLLRIGKKNSILQRKRSEPSPGSSGGIME- 571 Query: 740 EIIQQIVQHDREMAHCAHRVQAAASATPTPTPVIWTPLIQAPLQAAAATTSVAIALTHHP 799 Q +VQHDR+MA + A + PV+W PL+ APLQAAA T++VAIALTH Sbjct: 572 ---QHLVQHDRDMARGVRGRAPSTGAQLSGKPVLWEPLVHAPLQAAAVTSNVAIALTHQ- 627 Query: 800 RLPAAIFRPPPGSGLG-----NLGAGQTPRHLKRLQSLIPSALGSASPASSPSQVDTPSS 854 R P + P + L + G+ +P L+P G P +S S++ P + Sbjct: 628 RGPLPLSPDSPATLLARSAWRSAGSPASP--------LVPVRAG---PWASTSRLPAPPA 676 Query: 855 SSFHIQ-QLAGFSAPAGLSPLLPSSSSSPPPGACGSP-SAPTPSAGVAATTIAGFGHFHK 912 + H AG S + L P P G G P SA PS AT G G + Sbjct: 677 RTLHASLSRAGRSQVSLLGP--PPGGGGRRLGPRGRPLSASQPSLPQRAT---GDGSPGR 731 Query: 913 ALGGSLSSSDSPLLTPLQPGARSPQAAQPSPAPP 946 GS S LL A+ P+ P PA P Sbjct: 732 KGSGSERLPPSGLLAKPPRTAQPPRPPVPEPATP 765 Score = 34.3 bits (77), Expect = 0.73 Identities = 48/153 (31%), Positives = 54/153 (35%), Gaps = 32/153 (20%) Query: 989 GPLSTPETPPRQPEPPSLVAGASGGASPVGFTPRGGLSPPGHSPGPP-RTFPSAPPRASG 1047 GPL P S A ASP+ G + P PP RT ++ RA Sbjct: 629 GPLPLSPDSPATLLARSAWRSAGSPASPLVPVRAGPWASTSRLPAPPARTLHASLSRAGR 688 Query: 1048 SHGSLLLPPASSPPPPQVPQRRGTPPLTPGRLTQDLKLISASQPALPQDGAQTLRRASPH 1107 S SLL PPP RR P P +SASQP+LPQ R Sbjct: 689 SQVSLL------GPPPGGGGRRLGPRGRP---------LSASQPSLPQ------RATGDG 727 Query: 1108 SSGESMAAFPLFPRAGGGSGGSGSSGGLGPPGR 1140 S G R G GS SG L P R Sbjct: 728 SPG----------RKGSGSERLPPSGLLAKPPR 750 Score = 33.5 bits (75), Expect = 1.3 Identities = 31/86 (36%), Positives = 37/86 (43%), Gaps = 10/86 (11%) Query: 94 RRFRGSLASLGSRGGGSGGTGSGSSHGHLHDSAEERRLIAEGDASPGE-----DRTPP-G 147 R R ++ LG GG GG G L S A GD SPG +R PP G Sbjct: 685 RAGRSQVSLLGPPPGG-GGRRLGPRGRPLSASQPSLPQRATGDGSPGRKGSGSERLPPSG 743 Query: 148 LAAEPERPGASAQPAASPPPPQQPPQ 173 L A+P R +AQP P P P+ Sbjct: 744 LLAKPPR---TAQPPRPPVPEPATPR 766 >gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2 [Homo sapiens] Length = 676 Score = 191 bits (486), Expect = 3e-48 Identities = 137/486 (28%), Positives = 241/486 (49%), Gaps = 42/486 (8%) Query: 235 GSQKAVER-EQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGN--LIIIPVGITFFKDEN 291 GSQ+ +R +++ K ++ P S+ + W + L + N L+I + E Sbjct: 122 GSQEPADRGRRKKTKKKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLICRACFDELQSEY 181 Query: 292 TTPWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKY-LKSWFMVDFISSI 350 W+V + +D +++D+++ RTG + + ++ D R+ Y + F +D +S + Sbjct: 182 LMLWLVLDYSADVLYVLDVLVRARTGFL--EQGLMVSDTNRLWQHYKTTTQFKLDVLSLV 239 Query: 351 PVDYIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYD 410 P D +L V T VRF RLL+ SRL + + E T Sbjct: 240 PTDLAYLKVGTNYPE-----------VRFN------RLLKFSRLFEFFDRTE-----TRT 277 Query: 411 LASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMV--NNSWGKQYSYA 468 + RI NL+ +L++ HW+ C+ F + F D WV N + + ++Y Y+ Sbjct: 278 NYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYS 337 Query: 469 LFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQ 528 L+ + + IG PV + ++ +VG +A +G+ ++I ++++SR ++Q Sbjct: 338 LYWSTLTLTTIGE-TPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQ 396 Query: 529 EKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQG-KMFDEESILGELSEPLREEI-INFNC 586 K ++QYM F K+ D R+ ++++ + K DE+ +L L + L+ EI IN + Sbjct: 397 AKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHL 456 Query: 587 RKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKG 646 L + +F + + + ++ KLR VF PGDYI ++G IGK+MY I G ++V+ Sbjct: 457 DTL-KKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADD 515 Query: 647 --NKETKLADGSYFGEICLL------TRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPM 698 + L+DGSYFGEI +L + RRTA++R+ Y L+ LS D+ E L EYP Sbjct: 516 GVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPE 575 Query: 699 MRRAFE 704 ++A E Sbjct: 576 AKKALE 581 >gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Homo sapiens] Length = 694 Score = 190 bits (482), Expect = 8e-48 Identities = 134/477 (28%), Positives = 236/477 (49%), Gaps = 41/477 (8%) Query: 243 EQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGN--LIIIPVGITFFKDENTTPWIVFNV 300 E+++ K ++ P S+ + W + L + N L+I + E W+V + Sbjct: 149 EEKKTKKKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDY 208 Query: 301 VSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKY-LKSWFMVDFISSIPVDYIFLIV 359 +D +++D+++ RTG + + ++ D R+ Y + F +D +S +P D +L V Sbjct: 209 SADVLYVLDVLVRARTGFL--EQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLKV 266 Query: 360 ETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIV 419 T VRF RLL+ SRL + + E T + RI Sbjct: 267 GTNYPE-----------VRFN------RLLKFSRLFEFFDRTE-----TRTNYPNMFRIG 304 Query: 420 NLIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMV--NNSWGKQYSYALFKAMSHML 477 NL+ +L++ HW+ C+ F + F D WV N + + ++Y Y+L+ + + Sbjct: 305 NLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWSTLTLT 364 Query: 478 CIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQY 537 IG PV + ++ +VG +A +G+ ++I ++++SR ++Q K ++QY Sbjct: 365 TIGE-TPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQY 423 Query: 538 MSFHKLPPDTRQRIHDYYEHRYQG-KMFDEESILGELSEPLREEI-INFNCRKLVASMPL 595 M F K+ D R+ ++++ + K DE+ +L L + L+ EI IN + L + + Sbjct: 424 MQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTL-KKVRI 482 Query: 596 FANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKG--NKETKLA 653 F + + + ++ KLR VF PGDYI ++G IGK+MY I G ++V+ + L+ Sbjct: 483 FQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLS 542 Query: 654 DGSYFGEICLL------TRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFE 704 DGSYFGEI +L + RRTA++R+ Y L+ LS D+ E L EYP ++A E Sbjct: 543 DGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALE 599 >gi|13540549 potassium voltage-gated channel, subfamily H, member 6 isoform 1 [Homo sapiens] Length = 994 Score = 186 bits (471), Expect = 2e-46 Identities = 132/480 (27%), Positives = 223/480 (46%), Gaps = 51/480 (10%) Query: 253 WIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFF---KDENT--------TPWIVFNVV 301 W I YS F+ WD +LLL++ + P F +DE+ +P V +++ Sbjct: 247 WTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPLTVVDLI 306 Query: 302 SDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVET 361 D F++D+V+NFRT V N E++ P+RI + Y K WF++D +++IP D LI T Sbjct: 307 VDIMFVVDIVINFRT-TYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFD--LLIFRT 363 Query: 362 RIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNL 421 D T ++ LL+ RL RL+R + + Y A V + L Sbjct: 364 GSDET-------------TTLIGLLKTARLLRLVRVARKLDR-----YSEYGAAVLFL-L 404 Query: 422 IGMMLLLCHWDGCLQFLV-----PMLQD---FPDDCWVSINNMVNNS-------WGKQYS 466 + L+ HW C+ + + P L+ + D V + N S +Y Sbjct: 405 MCTFALIAHWLACIWYAIGNVERPYLEHKIGWLDSLGVQLGKRYNGSDPASGPSVQDKYV 464 Query: 467 YALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQ 526 AL+ S + +G+G +P S+ ++ M++G+ YA G+ +A+IQ L S + Sbjct: 465 TALYFTFSSLTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTAR 524 Query: 527 YQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQ-GKMFDEESILGELSEPLREEIINFN 585 Y + +V++++ FH++P RQR+ +Y++H + D ++L E L+ +I Sbjct: 525 YHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHL 584 Query: 586 CRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTK 645 R L+ P F+ A + ++ K + PGD ++ G + +YFI G + +L Sbjct: 585 HRALLQHCPAFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRD 644 Query: 646 GNKETKLADGSYFGEICLL--TRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAF 703 L FGE L G+ +A VRA TYC L+ + + EVL+ YP +F Sbjct: 645 DVVVAILGKNDIFGEPVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESF 704 >gi|27886653 potassium voltage-gated channel, subfamily H, member 7 isoform 1 [Homo sapiens] Length = 1196 Score = 178 bits (451), Expect = 3e-44 Identities = 130/483 (26%), Positives = 225/483 (46%), Gaps = 52/483 (10%) Query: 252 FWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDE-----------NTTPWIVFNV 300 F I+H YS F+ WD +LLL++ I P F ++ + +P V ++ Sbjct: 398 FTILH-YSPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDL 456 Query: 301 VSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVE 360 + D F+ID+++NFRT V N E++ DP +I + Y K WF++D +++IP D LI Sbjct: 457 IVDIMFIIDILINFRT-TYVNQNEEVVSDPAKIAIHYFKGWFLIDMVAAIPFD--LLIFG 513 Query: 361 TRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVN 420 + D T ++ LL+ RL RL+R + + Y A V ++ Sbjct: 514 SGSDET-------------TTLIGLLKTARLLRLVRVARKLDR-----YSEYGAAVLML- 554 Query: 421 LIGMMLLLCHWDGCLQFLV-----PMLQD---FPDDCWVSINNMVNNSWGK-------QY 465 L+ + L+ HW C+ + + P L D + D I N+S +Y Sbjct: 555 LMCIFALIAHWLACIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKY 614 Query: 466 SYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRR 525 AL+ S + +G+G +P S+ ++ M++G+ YA G+ +A+IQ L S Sbjct: 615 VTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTA 674 Query: 526 QYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRY-QGKMFDEESILGELSEPLREEIINF 584 +Y + +V++++ FH++P RQR+ +Y++H + D +L E L+ +I Sbjct: 675 RYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLH 734 Query: 585 NCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLT 644 + L+ + F A + ++ K + PGD ++ G + +YF+ G + +L Sbjct: 735 LNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILK 794 Query: 645 KGNKETKLADGSYFGEICLL--TRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRA 702 L FGE+ L G+ A VRA TYC L+ + ++ EVL+ YP Sbjct: 795 DDIVVAILGKNDIFGEMVHLYAKPGKSNADVRALTYCDLHKIQREDLLEVLDMYPEFSDH 854 Query: 703 FET 705 F T Sbjct: 855 FLT 857 >gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1 [Homo sapiens] Length = 759 Score = 175 bits (444), Expect = 2e-43 Identities = 124/483 (25%), Positives = 241/483 (49%), Gaps = 43/483 (8%) Query: 237 QKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITF--FKDENTTP 294 +K+ ++++E K +I P + + W + L ++ N ++ F + + Sbjct: 211 EKSKDKKEEEKKEVV--VIDPSGNTYYNWLFCITLPVMYNWTMVIARACFDELQSDYLEY 268 Query: 295 WIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSW-FMVDFISSIPVD 353 W++ + VSD +LID+ + RTG + + ++ + ++ KY + F +D +S IP D Sbjct: 269 WLILDYVSDIVYLIDMFVRTRTGYL--EQGLLVKEELKLINKYKSNLQFKLDVLSLIPTD 326 Query: 354 YIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLAS 413 ++ + + L RLLR SR+ + + E T Sbjct: 327 LLYFKLGWNYPE-----------------IRLNRLLRFSRMFEFFQRTE-----TRTNYP 364 Query: 414 AVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPDDCWV--SINNMVNNSWGKQYSYALFK 471 + RI NL+ ++++ HW+ C+ + + F +D WV IN+ ++Y Y+L+ Sbjct: 365 NIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYW 424 Query: 472 AMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKY 531 + + IG PV S+ ++ ++G +A +G+ ++I +++++R ++Q + Sbjct: 425 STLTLTTIGE-TPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARI 483 Query: 532 KQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKM-FDEESILGELSEPLREEI-INFNCRKL 589 ++QYM F + D +R+ ++++ + K DE+ +L L + LR EI IN + L Sbjct: 484 DAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTL 543 Query: 590 VASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKG--N 647 + +FA+ + + ++ KL+ +V+ PGDYI ++G IG++MY I+ G ++V+ Sbjct: 544 -KKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVT 602 Query: 648 KETKLADGSYFGEICLL------TRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRR 701 + L+DGSYFGEI +L RRTA++++ Y L+ LS D+ E L EYP + Sbjct: 603 QFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKT 662 Query: 702 AFE 704 E Sbjct: 663 MLE 665 >gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [Homo sapiens] Length = 690 Score = 175 bits (444), Expect = 2e-43 Identities = 124/483 (25%), Positives = 241/483 (49%), Gaps = 43/483 (8%) Query: 237 QKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITF--FKDENTTP 294 +K+ ++++E K +I P + + W + L ++ N ++ F + + Sbjct: 142 EKSKDKKEEEKKEVV--VIDPSGNTYYNWLFCITLPVMYNWTMVIARACFDELQSDYLEY 199 Query: 295 WIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSW-FMVDFISSIPVD 353 W++ + VSD +LID+ + RTG + + ++ + ++ KY + F +D +S IP D Sbjct: 200 WLILDYVSDIVYLIDMFVRTRTGYL--EQGLLVKEELKLINKYKSNLQFKLDVLSLIPTD 257 Query: 354 YIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLAS 413 ++ + + L RLLR SR+ + + E T Sbjct: 258 LLYFKLGWNYPE-----------------IRLNRLLRFSRMFEFFQRTE-----TRTNYP 295 Query: 414 AVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPDDCWV--SINNMVNNSWGKQYSYALFK 471 + RI NL+ ++++ HW+ C+ + + F +D WV IN+ ++Y Y+L+ Sbjct: 296 NIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYW 355 Query: 472 AMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKY 531 + + IG PV S+ ++ ++G +A +G+ ++I +++++R ++Q + Sbjct: 356 STLTLTTIGE-TPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARI 414 Query: 532 KQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKM-FDEESILGELSEPLREEI-INFNCRKL 589 ++QYM F + D +R+ ++++ + K DE+ +L L + LR EI IN + L Sbjct: 415 DAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTL 474 Query: 590 VASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKG--N 647 + +FA+ + + ++ KL+ +V+ PGDYI ++G IG++MY I+ G ++V+ Sbjct: 475 -KKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVT 533 Query: 648 KETKLADGSYFGEICLL------TRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRR 701 + L+DGSYFGEI +L RRTA++++ Y L+ LS D+ E L EYP + Sbjct: 534 QFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKT 593 Query: 702 AFE 704 E Sbjct: 594 MLE 596 >gi|26051273 voltage-gated potassium channel, subfamily H, member 2 isoform c [Homo sapiens] Length = 819 Score = 174 bits (442), Expect = 3e-43 Identities = 124/474 (26%), Positives = 214/474 (45%), Gaps = 54/474 (11%) Query: 253 WIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTT------------PWIVFNV 300 W I YS F+ WD +LLL++ + P F E P V ++ Sbjct: 58 WTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDL 117 Query: 301 VSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVE 360 + D F++D+++NFRT V N E++ P RI + Y K WF++D +++IP D + Sbjct: 118 IVDIMFIVDILINFRT-TYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSG 176 Query: 361 TRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVN 420 + + KTAR LR+VR + +L R Y +AV+ + Sbjct: 177 SEELIGLLKTARLLRLVRVAR--------KLDRYSEY--------------GAAVLFL-- 212 Query: 421 LIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMVNNSWGKQYSY------------- 467 L+ L+ HW C+ + + ++ D + + + + GK Y+ Sbjct: 213 LMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYV 272 Query: 468 -ALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQ 526 AL+ S + +G+G +P S+ ++ M++G+ YA G+ +A+IQ L S + Sbjct: 273 TALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTAR 332 Query: 527 YQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQ-GKMFDEESILGELSEPLREEIINFN 585 Y + +V +++ FH++P RQR+ +Y++H + D ++L E L+ +I Sbjct: 333 YHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHL 392 Query: 586 CRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTK 645 R L+ F A + ++ K + PGD ++ G + +YFI G + +L Sbjct: 393 NRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRG 452 Query: 646 GNKETKLADGSYFGE-ICLLTR-GRRTASVRADTYCRLYSLSVDNFNEVLEEYP 697 L FGE + L R G+ VRA TYC L+ + D+ EVL+ YP Sbjct: 453 DVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYP 506 Score = 35.0 bits (79), Expect = 0.43 Identities = 30/102 (29%), Positives = 46/102 (45%), Gaps = 22/102 (21%) Query: 98 GSLASLGSRGGGSGGTGSGSSHGHLHDSAEERRLIAEGDASPGEDRTPPGLAAEPERPGA 157 G +++LG G+G + G G +S + G +SP ++E E PG Sbjct: 563 GEVSALGPGRAGAGPSSRGRPGGPWGESP------SSGPSSPE--------SSEDEGPGR 608 Query: 158 SAQPA-----ASPPPPQQPP--QPASASCEQPSVDTAIKVEG 192 S+ P +SP PP +PP +P CE+ S DT + G Sbjct: 609 SSSPLRLVPFSSPRPPGEPPGGEPLMEDCEKSS-DTCNPLSG 649 >gi|4557729 voltage-gated potassium channel, subfamily H, member 2 isoform a [Homo sapiens] Length = 1159 Score = 174 bits (442), Expect = 3e-43 Identities = 124/474 (26%), Positives = 214/474 (45%), Gaps = 54/474 (11%) Query: 253 WIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTT------------PWIVFNV 300 W I YS F+ WD +LLL++ + P F E P V ++ Sbjct: 398 WTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDL 457 Query: 301 VSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVE 360 + D F++D+++NFRT V N E++ P RI + Y K WF++D +++IP D + Sbjct: 458 IVDIMFIVDILINFRT-TYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSG 516 Query: 361 TRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVN 420 + + KTAR LR+VR + +L R Y +AV+ + Sbjct: 517 SEELIGLLKTARLLRLVRVAR--------KLDRYSEY--------------GAAVLFL-- 552 Query: 421 LIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMVNNSWGKQYSY------------- 467 L+ L+ HW C+ + + ++ D + + + + GK Y+ Sbjct: 553 LMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYV 612 Query: 468 -ALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQ 526 AL+ S + +G+G +P S+ ++ M++G+ YA G+ +A+IQ L S + Sbjct: 613 TALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTAR 672 Query: 527 YQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQ-GKMFDEESILGELSEPLREEIINFN 585 Y + +V +++ FH++P RQR+ +Y++H + D ++L E L+ +I Sbjct: 673 YHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHL 732 Query: 586 CRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTK 645 R L+ F A + ++ K + PGD ++ G + +YFI G + +L Sbjct: 733 NRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRG 792 Query: 646 GNKETKLADGSYFGE-ICLLTR-GRRTASVRADTYCRLYSLSVDNFNEVLEEYP 697 L FGE + L R G+ VRA TYC L+ + D+ EVL+ YP Sbjct: 793 DVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYP 846 Score = 35.0 bits (79), Expect = 0.43 Identities = 30/102 (29%), Positives = 46/102 (45%), Gaps = 22/102 (21%) Query: 98 GSLASLGSRGGGSGGTGSGSSHGHLHDSAEERRLIAEGDASPGEDRTPPGLAAEPERPGA 157 G +++LG G+G + G G +S + G +SP ++E E PG Sbjct: 903 GEVSALGPGRAGAGPSSRGRPGGPWGESP------SSGPSSPE--------SSEDEGPGR 948 Query: 158 SAQPA-----ASPPPPQQPP--QPASASCEQPSVDTAIKVEG 192 S+ P +SP PP +PP +P CE+ S DT + G Sbjct: 949 SSSPLRLVPFSSPRPPGEPPGGEPLMEDCEKSS-DTCNPLSG 989 >gi|4504831 potassium voltage-gated channel, subfamily H, member 1 isoform 2 [Homo sapiens] Length = 962 Score = 173 bits (439), Expect = 8e-43 Identities = 129/500 (25%), Positives = 221/500 (44%), Gaps = 57/500 (11%) Query: 235 GSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTP 294 GS + +QE K+ I+H Y F+ WD +L+L I++P ++F +N Sbjct: 191 GSDILPQYKQEAPKTPPHIILH-YCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNNVA 249 Query: 295 WIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDY 354 W+V + + D FL+D+VLNF T V E+I DP+ I+M YLK+WF++D +S +P D Sbjct: 250 WLVVDSIVDVIFLVDIVLNFHTTFVGPAG-EVISDPKLIRMNYLKTWFVIDLLSCLPYDV 308 Query: 355 IFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASA 414 I +D + +L++V RLLRL R+ R + + E A+ Sbjct: 309 INAF--ENVDEGISSLFSSLKVV---------RLLRLGRVARKLDHYIEYG------AAV 351 Query: 415 VVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMVNNSW--------GKQYS 466 +V +V + G L HW C+ + + + F +D + NNSW G Y Sbjct: 352 LVLLVCVFG---LAAHWMACIWYSIGDYEIFDED----TKTIRNNSWLYQLAMDIGTPYQ 404 Query: 467 Y--------------------ALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCY 506 + +L+ M+ + +G+G AP + + M++G+ Y Sbjct: 405 FNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLY 464 Query: 507 AMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRY-QGKMFD 565 A G+ T + Q + ++ +Y E V ++ +++P +R+ DY + + D Sbjct: 465 ATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGID 524 Query: 566 EESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIRE 625 E +L + +R +I RK+ P F A + ++ + + PGD I Sbjct: 525 TEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHA 584 Query: 626 GTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICL--LTRGRRTASVRADTYCRLYS 683 G + F+ G + V+ L G FG++ T + A+VRA TYC L+ Sbjct: 585 GESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHV 644 Query: 684 LSVDNFNEVLEEYPMMRRAF 703 + D +VLE Y +F Sbjct: 645 IKRDALQKVLEFYTAFSHSF 664 >gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens] Length = 664 Score = 171 bits (433), Expect = 4e-42 Identities = 125/473 (26%), Positives = 227/473 (47%), Gaps = 43/473 (9%) Query: 248 KSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITF--FKDENTTPWIVFNVVSDTF 305 K +++ P D+ + W + + ++ N ++ F + W+V + VSD Sbjct: 126 KKFELFVLDPAGDWYYCWLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDYVSDVV 185 Query: 306 FLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSW-FMVDFISSIPVDYIFLIVETRID 364 ++ DL + RTG + + ++ D ++++ Y+ + F +D S IP D I+ V+ Sbjct: 186 YIADLFIRLRTGFL--EQGLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDIHSP 243 Query: 365 SEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGM 424 VRF RLL +R+ + + E T + RI NL+ Sbjct: 244 E-----------VRFN------RLLHFARMFEFFDRTE-----TRTNYPNIFRISNLVLY 281 Query: 425 MLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMVNNSWG---KQYSYALFKAMSHMLCIGY 481 +L++ HW+ C+ + + F D WV N+ + +G ++Y Y L+ + + IG Sbjct: 282 ILVIIHWNACIYYAISKSIGFGVDTWV-YPNITDPEYGYLAREYIYCLYWSTLTLTTIGE 340 Query: 482 GRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFH 541 PV + + ++G +A +G+ ++I +++++R ++Q K V+ YM F Sbjct: 341 -TPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFR 399 Query: 542 KLPPDTRQRIHDYYEHRYQGKM-FDEESILGELSEPLREEI-INFNCRKLVASMPLFANA 599 K+ ++ ++++ + K DE IL L LR EI IN + L + +F + Sbjct: 400 KVSKGMEAKVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLSTL-KKVRIFHDC 458 Query: 600 DPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKG--NKETKLADGSY 657 + + ++ KLR +VF PGDYI R+G IGK+MY I+ G ++V+ + L+ GS Sbjct: 459 EAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSC 518 Query: 658 FGEICLLT------RGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFE 704 FGEI +L RRTA++R+ Y L+ LS D+ E + EYP ++ E Sbjct: 519 FGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYPDAKKVLE 571 >gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens] Length = 575 Score = 170 bits (431), Expect = 7e-42 Identities = 121/478 (25%), Positives = 229/478 (47%), Gaps = 41/478 (8%) Query: 254 IIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITF--FKDENTTPWIVFNVVSDTFFLIDLV 311 ++ P D+ ++W TM+ ++ NLII+ F + W+V + SD +L+D+V Sbjct: 26 VLDPSGDYYYWWLNTMVFPVMYNLIILVCRACFPDLQHGYLVAWLVLDYTSDLLYLLDMV 85 Query: 312 LNFRTGIVVEDNTEIILDPQRIKMKYLKSW-FMVDFISSIPVDYIFLIVETRIDSEVYKT 370 + F TG + + +++D RI +Y+++W F +D S +P D +++ Sbjct: 86 VRFHTGFL--EQGILVVDKGRISSRYVRTWSFFLDLASLMPTDVVYV------------- 130 Query: 371 ARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCH 430 R+ T L L R LR RL + E T RI L+ + ++ H Sbjct: 131 ----RLGPHTPTLRLNRFLRAPRLFEAFDRTE-----TRTAYPNAFRIAKLMLYIFVVIH 181 Query: 431 WDGCLQFLVPMLQDFPDDCWVSINNMVNN--SWGKQYSYALFKAMSHMLCIGYGRQAPVG 488 W+ CL F + F D WV + +QY Y+ + S ++ G P Sbjct: 182 WNSCLYFALSRYLGFGRDAWVYPDPAQPGFERLRRQYLYSFY--FSTLILTTVGDTPPPA 239 Query: 489 MSDVWLTMLS-MIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDT 547 + +L M+ ++ +A +G +++I +++++ + + V++YM + Sbjct: 240 REEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVKKYMKLQHVNRKL 299 Query: 548 RQRIHDYYEH-RYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTS 606 +R+ D+Y+H + KM +E +IL L E LR E+ ++ + +F N + + + Sbjct: 300 ERRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQIFQNCEASLLEE 359 Query: 607 MLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKG--NKETKLADGSYFGEICL- 663 ++ KL+ + + PG+Y+ R+G IG++MY I+ G ++V+ + L G YFGEI + Sbjct: 360 LVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGITQYAVLGAGLYFGEISII 419 Query: 664 -----LTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGK 716 ++ RRTA++++ Y L+ LS ++ EVL EYP + E + L ++ K Sbjct: 420 NIKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEYPQAQTIMEEKGREILLKMNK 477 >gi|22024390 potassium voltage-gated channel, subfamily H, member 5 isoform 1 [Homo sapiens] Length = 988 Score = 170 bits (430), Expect = 9e-42 Identities = 130/495 (26%), Positives = 218/495 (44%), Gaps = 48/495 (9%) Query: 235 GSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTP 294 GS + +QE K+ I+H Y F+ WD +L+L I++P ++F +N Sbjct: 188 GSDILPQYKQEAPKTPPHIILH-YCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIA 246 Query: 295 WIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDY 354 W+V + V D FL+D+VLNF T V E+I DP+ I+M YLK+WF++D +S +P D Sbjct: 247 WLVLDSVVDVIFLVDIVLNFHT-TFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDI 305 Query: 355 IFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASA 414 I +D + +L++V RLLRL R+ R + + E A+ Sbjct: 306 INAF--ENVDEGISSLFSSLKVV---------RLLRLGRVARKLDHYLEYG------AAV 348 Query: 415 VVRIVNLIGMMLLLCHWDGCLQFLV-------PMLQDFPDDCW-------VSINNMVNNS 460 +V +V + G L+ HW C+ + + + D W + N S Sbjct: 349 LVLLVCVFG---LVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTS 405 Query: 461 WG---------KQYSYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIG 511 G Y +L+ M+ + IG+G AP + ++ M+VG+ YA G Sbjct: 406 AGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFG 465 Query: 512 HATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRY-QGKMFDEESIL 570 + T + Q + ++ +Y E V ++ +++P +R+ DY + K D E +L Sbjct: 466 NVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVL 525 Query: 571 GELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGK 630 + +R +I RK+ P F A + ++ + + PGD I G Sbjct: 526 SICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVD 585 Query: 631 KMYFIQHGVVSVLTKGNKETKLADGSYFGEICL--LTRGRRTASVRADTYCRLYSLSVDN 688 + F+ G + V+ L G FG+I T A+VRA TYC L+ + + Sbjct: 586 ALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREA 645 Query: 689 FNEVLEEYPMMRRAF 703 +VL+ Y +F Sbjct: 646 LLKVLDFYTAFANSF 660 >gi|27886648 potassium voltage-gated channel, subfamily H, member 5 isoform 2 [Homo sapiens] Length = 624 Score = 170 bits (430), Expect = 9e-42 Identities = 130/495 (26%), Positives = 218/495 (44%), Gaps = 48/495 (9%) Query: 235 GSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTP 294 GS + +QE K+ I+H Y F+ WD +L+L I++P ++F +N Sbjct: 130 GSDILPQYKQEAPKTPPHIILH-YCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIA 188 Query: 295 WIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDY 354 W+V + V D FL+D+VLNF T V E+I DP+ I+M YLK+WF++D +S +P D Sbjct: 189 WLVLDSVVDVIFLVDIVLNFHT-TFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDI 247 Query: 355 IFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASA 414 I +D + +L++V RLLRL R+ R + + E A+ Sbjct: 248 INAF--ENVDEGISSLFSSLKVV---------RLLRLGRVARKLDHYLEYG------AAV 290 Query: 415 VVRIVNLIGMMLLLCHWDGCLQFLV-------PMLQDFPDDCW-------VSINNMVNNS 460 +V +V + G L+ HW C+ + + + D W + N S Sbjct: 291 LVLLVCVFG---LVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTS 347 Query: 461 WG---------KQYSYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIG 511 G Y +L+ M+ + IG+G AP + ++ M+VG+ YA G Sbjct: 348 AGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFG 407 Query: 512 HATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRY-QGKMFDEESIL 570 + T + Q + ++ +Y E V ++ +++P +R+ DY + K D E +L Sbjct: 408 NVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVL 467 Query: 571 GELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGK 630 + +R +I RK+ P F A + ++ + + PGD I G Sbjct: 468 SICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVD 527 Query: 631 KMYFIQHGVVSVLTKGNKETKLADGSYFGEICL--LTRGRRTASVRADTYCRLYSLSVDN 688 + F+ G + V+ L G FG+I T A+VRA TYC L+ + + Sbjct: 528 ALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREA 587 Query: 689 FNEVLEEYPMMRRAF 703 +VL+ Y +F Sbjct: 588 LLKVLDFYTAFANSF 602 >gi|27886651 potassium voltage-gated channel, subfamily H, member 6 isoform 2 [Homo sapiens] Length = 905 Score = 170 bits (430), Expect = 9e-42 Identities = 123/465 (26%), Positives = 206/465 (44%), Gaps = 74/465 (15%) Query: 253 WIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFF---KDENT--------TPWIVFNVV 301 W I YS F+ WD +LLL++ + P F +DE+ +P V +++ Sbjct: 247 WTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPLTVVDLI 306 Query: 302 SDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVET 361 D F++D+V+NFRT V N E++ P+RI + Y K WF++D +++IP D LI T Sbjct: 307 VDIMFVVDIVINFRT-TYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFD--LLIFRT 363 Query: 362 RIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNL 421 D T ++ LL+ RL RL+R + + Y A V + L Sbjct: 364 GSDET-------------TTLIGLLKTARLLRLVRVARKLDR-----YSEYGAAVLFL-L 404 Query: 422 IGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMVNNSWGKQYSYALFKAMSHMLCIGY 481 + L+ HW C+ L +G+ Sbjct: 405 MCTFALIAHWLACICSLTS--------------------------------------VGF 426 Query: 482 GRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFH 541 G +P S+ ++ M++G+ YA G+ +A+IQ L S +Y + +V++++ FH Sbjct: 427 GNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFH 486 Query: 542 KLPPDTRQRIHDYYEHRYQ-GKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANAD 600 ++P RQR+ +Y++H + D ++L E L+ +I R L+ P F+ A Sbjct: 487 QIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAG 546 Query: 601 PNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGE 660 + ++ K + PGD ++ G + +YFI G + +L L FGE Sbjct: 547 KGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGE 606 Query: 661 ICLL--TRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAF 703 L G+ +A VRA TYC L+ + + EVL+ YP +F Sbjct: 607 PVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESF 651 >gi|6912446 potassium voltage-gated channel, subfamily H, member 4 [Homo sapiens] Length = 1017 Score = 165 bits (418), Expect = 2e-40 Identities = 206/893 (23%), Positives = 334/893 (37%), Gaps = 161/893 (18%) Query: 207 RLGQAGFMQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWD 266 R GQ G +P V ++ + G + + ++H YS + WD Sbjct: 185 RRGQGGMKANNNVFEPKPSVPEYKVASVGGSRCL-------------LLH-YSVSKAIWD 230 Query: 267 LTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNVVSDT----FFLIDLVLNFRTGIVVED 322 +LL + +P + F D++T +VSD F++D++LNFRT V + Sbjct: 231 GLILLATFYVAVTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVSQS 290 Query: 323 NTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVETRIDSEVYKTARALRIVRFTKI 382 ++I P+ I + YL +WF +D I+++P D +++ T T + Sbjct: 291 G-QVISAPRSIGLHYLATWFFIDLIAALPFDLLYIFNIT-----------------VTSL 332 Query: 383 LSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLV--- 439 + LL+ +RL RL+R + + E Y SAVV + L+ + LL HW C+ +++ Sbjct: 333 VHLLKTVRLLRLLRLLQKLER-----YSQCSAVV-LTLLMSVFALLAHWMACIWYVIGRR 386 Query: 440 ------PMLQDFPDDCWVS----------INNMVNN-SWGKQYSYALFKAMSHMLCIGYG 482 P+L D W+ +N V S Y AL+ +S + +G+G Sbjct: 387 EMEANDPLLWDIG---WLHELGKRLEVPYVNGSVGGPSRRSAYIAALYFTLSSLTSVGFG 443 Query: 483 RQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHK 542 ++ ++ +M++GA +A+ G+ TA+IQ + S R Y + K ++ ++ H+ Sbjct: 444 NVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHR 503 Query: 543 LPPDTRQRIHDYYEHRYQ-GKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADP 601 LP +QR+ +Y++ + D +L + + LR +I + + + +PLF A Sbjct: 504 LPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIA-MHLNREILQLPLFGAASR 562 Query: 602 NFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFG-- 659 + ++ ++ PG+Y++R G + Y++ G + VL L G G Sbjct: 563 GCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGSLEVLRDNMVLAILGKGDLIGAD 622 Query: 660 --------------EICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFET 705 L T +A V+A TYC L LS EVL YP AF Sbjct: 623 IPEPGQEPGLGADPNFVLKT----SADVKALTYCGLQQLSSRGLAEVLRLYPEYGAAF-- 676 Query: 706 VALDRLDRIGKKNSILLHKVQHDLNSGVFNYQENEIIQQIVQHDREMAHCAHR-----VQ 760 R G + + Q SG+ + + + Q + + + + Sbjct: 677 -------RAGLPRDLTFNLRQGSDTSGLSRFSRSPRLSQ--PRSESLGSSSDKTLPSITE 727 Query: 761 AAASATPTPTPVIWTPLIQAPLQAAAATTSVAIALTHH-PRLPAAIFRPPPGSGLGNLGA 819 A + A P P PL+ L A S+ L P A + P L A Sbjct: 728 AESGAEPGGGPRPRRPLLLPNLSPARPRGSLVSLLGEELPPFSALVSSPSLSPSLSPALA 787 Query: 820 GQ--------TPR---HLKRLQSLIPSALGSASPASSPSQVD-------TPSSSSFHIQQ 861 GQ PR K Q LIP P SP VD T + SF + Sbjct: 788 GQGHSASPHGPPRCSAAWKPPQLLIPPLGTFGPPDLSPRIVDGIEDSGSTAEAPSFRFSR 847 Query: 862 LAGFSAPAGLSPLLP-SSSSSPPPGACGSPSAPTPSAGV-----------------AATT 903 P LP S +PP G SP + + V + Sbjct: 848 ----------RPELPRPRSQAPPTGTRPSPELASEAEEVKEKVCRLNQEISRLNQEVSQL 897 Query: 904 IAGFGHFHKALGGSLSSSDSPLLTPLQPGARSPQAAQPSPAPPGARGGLGLPEHFLPPPP 963 H L L P + P PQ P +P +R PPP Sbjct: 898 SRELRHIMGLLQARLGPPGHPAGSAWTPDPPCPQLRPPCLSPCASR-----------PPP 946 Query: 964 SSRSPSSSPGQLGQPPGELSLGLATGPLSTPETPPRQPEPPSLVAGASGGASP 1016 S + + + G + G A L PP EP L ASP Sbjct: 947 SLQDTTLAEVHCPASVGTMETGTALLDLRPSILPPYPSEPDPLGPSPVPEASP 999 Score = 41.2 bits (95), Expect = 0.006 Identities = 72/274 (26%), Positives = 95/274 (34%), Gaps = 67/274 (24%) Query: 916 GSLSSSDSPLLTPLQPGAR---SPQAAQP------SPAPPGARGGL-GLPEHFLPP---- 961 GS S P +T + GA P+ +P SPA P RG L L LPP Sbjct: 715 GSSSDKTLPSITEAESGAEPGGGPRPRRPLLLPNLSPARP--RGSLVSLLGEELPPFSAL 772 Query: 962 -PPSSRSPSSSPGQLGQPPGELSLGLATGPLSTPETPPRQP---EPPSLVAGASGGASPV 1017 S SPS SP GQ G ++P PPR +PP L+ G P Sbjct: 773 VSSPSLSPSLSPALAGQ-----------GHSASPHGPPRCSAAWKPPQLLIPPLGTFGPP 821 Query: 1018 GFTPR--GGLSPPGHSPGPPRTFPSAPPRASGSHGSLLLPPASSPPPPQVPQRRGTPPLT 1075 +PR G+ G + P S P PP + P P++ Sbjct: 822 DLSPRIVDGIEDSGSTAEAPSFRFSRRPELPRPRSQA--PPTGTRPSPELASEAEEVKEK 879 Query: 1076 PGRLTQDLKLISASQPALPQDGAQTLRRASPHSSGESMAAFPLFPRAGGGSGGSGSSGGL 1135 RL Q++ ++ Q+ +Q L R H G A L Sbjct: 880 VCRLNQEISRLN-------QEVSQ-LSRELRHIMGLLQAR-------------------L 912 Query: 1136 GPPGRPYGAI-----PGQHVTLPRKTSSGSLPPP 1164 GPPG P G+ P + P + S PPP Sbjct: 913 GPPGHPAGSAWTPDPPCPQLRPPCLSPCASRPPP 946 Score = 31.2 bits (69), Expect = 6.2 Identities = 61/232 (26%), Positives = 78/232 (33%), Gaps = 53/232 (22%) Query: 982 LSLGLATGPLSTPETPPRQPEPPSLVAGASGGASPVGFTPRGGLSPPGHSPGP--PRTFP 1039 L G T LS PR +P S G+S + T + PG P P P P Sbjct: 688 LRQGSDTSGLSRFSRSPRLSQPRSESLGSSSDKTLPSITEAESGAEPGGGPRPRRPLLLP 747 Query: 1040 S-APPRASGSHGSLL---LPPASSPPPPQVPQRRGTPPLTPGRLTQDLKLISASQPALPQ 1095 + +P R GS SLL LPP S+ +P L+P + PAL Sbjct: 748 NLSPARPRGSLVSLLGEELPPFSA--------LVSSPSLSP-----------SLSPALAG 788 Query: 1096 DGAQTLRRASPHSSGESMAAFP----LFPRAGGGSGGSGSSGGLGPPGRPYGAIPGQHVT 1151 G ASPH AA+ L P G GPP + G Sbjct: 789 QG----HSASPHGPPRCSAAWKPPQLLIP----------PLGTFGPPDLSPRIVDG---- 830 Query: 1152 LPRKTSSGSLPPPLSLFGAR----ATSSGGPPLTAGPQREPGARPEPVRSKL 1199 + S + P F R S PP P E + E V+ K+ Sbjct: 831 --IEDSGSTAEAPSFRFSRRPELPRPRSQAPPTGTRPSPELASEAEEVKEKV 880 >gi|27437001 potassium voltage-gated channel, subfamily H, member 1 isoform 1 [Homo sapiens] Length = 989 Score = 165 bits (417), Expect = 3e-40 Identities = 129/516 (25%), Positives = 220/516 (42%), Gaps = 62/516 (12%) Query: 235 GSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTP 294 GS + +QE K+ I+H Y F+ WD +L+L I++P ++F +N Sbjct: 191 GSDILPQYKQEAPKTPPHIILH-YCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNNVA 249 Query: 295 WIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDY 354 W+V + + D FL+D+VLNF T V E+I DP+ I+M YLK+WF++D +S +P D Sbjct: 250 WLVVDSIVDVIFLVDIVLNFHTTFVGPAG-EVISDPKLIRMNYLKTWFVIDLLSCLPYDV 308 Query: 355 IFLIVETRIDSEVY----------------KTARALRIVRFTKILSLLRLLRLSRLIRYI 398 I S + + I L ++RLLRL R+ R + Sbjct: 309 INAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVARKL 368 Query: 399 HQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMVN 458 + E A+ +V +V + G L HW C+ + + + F +D + N Sbjct: 369 DHYIEYG------AAVLVLLVCVFG---LAAHWMACIWYSIGDYEIFDEDT----KTIRN 415 Query: 459 NSW--------GKQYSY--------------------ALFKAMSHMLCIGYGRQAPVGMS 490 NSW G Y + +L+ M+ + +G+G AP Sbjct: 416 NSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDI 475 Query: 491 DVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQR 550 + + M++G+ YA G+ T + Q + ++ +Y E V ++ +++P +R Sbjct: 476 EKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSER 535 Query: 551 IHDYYEHRY-QGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLT 609 + DY + + D E +L + +R +I RK+ P F A + ++ Sbjct: 536 VMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAM 595 Query: 610 KLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICL--LTRG 667 + + PGD I G + F+ G + V+ L G FG++ T Sbjct: 596 EFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLA 655 Query: 668 RRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAF 703 + A+VRA TYC L+ + D +VLE Y +F Sbjct: 656 QSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSF 691 >gi|27886667 potassium voltage-gated channel, subfamily H, member 8 [Homo sapiens] Length = 1107 Score = 159 bits (401), Expect = 2e-38 Identities = 118/522 (22%), Positives = 234/522 (44%), Gaps = 68/522 (13%) Query: 248 KSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDEN---TTPWIVFNVVSDT 304 K + F ++H +S F+ WD +LL + +P + F +++ T V ++ + Sbjct: 208 KKSKFILLH-FSTFKAGWDWLILLATFYVAVTVPYNVCFIGNDDLSTTRSTTVSDIAVEI 266 Query: 305 FFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVETRID 364 F+ID++LNFRT V + ++I + + I + Y+ +WF++D I+++P D ++ T Sbjct: 267 LFIIDIILNFRTTYVSKSG-QVIFEARSICIHYVTTWFIIDLIAALPFDLLYAFNVT--- 322 Query: 365 SEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGM 424 +V +L +RLLRL RL++ + ++ + H T + + L+ M Sbjct: 323 -----------VVSLVHLLKTVRLLRLLRLLQKLDRYSQ--HST-------IVLTLLMSM 362 Query: 425 MLLLCHWDGCLQFLVPMLQDFPDDC------------------WVSINNMVNNSWGKQYS 466 LL HW C+ +++ ++ + + N + S Y Sbjct: 363 FALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSAYI 422 Query: 467 YALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQ 526 AL+ +S + +G+G + ++ ++ +M++GA +A+ G+ TA+IQ + S Sbjct: 423 AALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSL 482 Query: 527 YQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQ-GKMFDEESILGELSEPLREEIINFN 585 Y + K ++ ++ H LP +QR+ +Y++ + D +L + + LR + I + Sbjct: 483 YHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSD-ITMH 541 Query: 586 CRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTK 645 K + + LF A + S+ ++ PG+Y++R+G + +YF+ G + VL Sbjct: 542 LNKEILQLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKD 601 Query: 646 GNKETKLADGSYFGEICLLTRG--RRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAF 703 L G G + + A V+A TYC L + + EVL+ YP F Sbjct: 602 SMVLAILGKGDLIGANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLDLYPEYAHKF 661 Query: 704 ETVALDRLDRIGKKNSILLHKVQHDLNSGVFNYQENEIIQQI 745 + +QHDL + E+++I ++ Sbjct: 662 ------------------VEDIQHDLTYNLREGHESDVISRL 685 >gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [Homo sapiens] Length = 1251 Score = 156 bits (394), Expect = 1e-37 Identities = 118/449 (26%), Positives = 211/449 (46%), Gaps = 53/449 (11%) Query: 265 WDLTMLLLMVGNLIIIPV--GITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVED 322 W +++ N +IPV + +N W++ + + D + +D+ + F+T + Sbjct: 659 WLFFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITV-FQTRLQFVR 717 Query: 323 NTEIILDPQRIKMKYLKSW-FMVDFISSIPVDYIFLIVETRIDSEVYKTARALRIVRFTK 381 +II D + ++ YLKS F +D +S +P+D+++L V Sbjct: 718 GGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVN------------------- 758 Query: 382 ILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVV-RIVNLIGMMLLLCHWDGCLQFLVP 440 LLRL R ++Y+ +E + L+ A V R++ +L H + CL + Sbjct: 759 -----PLLRLPRCLKYMAFFEFNSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWAS 813 Query: 441 MLQDFPDDCWVSINNMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMI 500 Q WV + G Y + A+ ++ IG G P + ++ +L+ Sbjct: 814 AYQGLGSTHWVY------DGVGNSYIRCYYFAVKTLITIG-GLPDPKTLFEIVFQLLNYF 866 Query: 501 VGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQ 560 G +++ IG ++ + + + Y+ +YM+F+K+P + R+ +YE+ + Sbjct: 867 TGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTWH 926 Query: 561 GK-MFDEESILGELSEPLREEI---INFNCRKLVASMPLFANADPNFVTSMLTKLRFEVF 616 + M DE ++ +L + +R ++ +N+N +V+ + LF D + ML +LR V+ Sbjct: 927 SQGMLDESELMVQLPDKMRLDLAIDVNYN---IVSKVALFQGCDRQMIFDMLKRLRSVVY 983 Query: 617 QPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETK-----LADGSYFGEICLLTRG---R 668 P DY+ ++G IG++MY IQ G V VL G + K L GS FGEI LL G R Sbjct: 984 LPNDYVCKKGEIGREMYIIQAGQVQVL--GGPDGKSVLVTLKAGSVFGEISLLAVGGGNR 1041 Query: 669 RTASVRADTYCRLYSLSVDNFNEVLEEYP 697 RTA+V A + L+ L + NE+L YP Sbjct: 1042 RTANVVAHGFTNLFILDKKDLNEILVHYP 1070 Score = 38.5 bits (88), Expect = 0.039 Identities = 38/137 (27%), Positives = 53/137 (38%), Gaps = 14/137 (10%) Query: 890 PSAPTPSAGVAATTIAGFGHFHKALGGSLSSSDSPL--LTPLQPGARSPQAAQPSPAPPG 947 P A TP AA + G A GG L+ + L L L+ A+ + + + + Sbjct: 1101 PRAGTPKLFNAALAMTGKMGGKGAKGGKLAHLRARLKELAALEAAAKQQELVEQAKSSQD 1160 Query: 948 ARG--GLGLPEHFLPP------PPSSRSPSSSPGQLGQPPGELSLGLATGPLSTPETPPR 999 +G G P+ P PP+ R+P PG P SLG G E P Sbjct: 1161 VKGEEGSAAPDQHTHPKEAATDPPAPRTPPEPPGSPPSSPPPASLGRPEG----EEEGPA 1216 Query: 1000 QPEPPSLVAGASGGASP 1016 +PE S+ S G P Sbjct: 1217 EPEEHSVRICMSPGPEP 1233 Score = 36.6 bits (83), Expect = 0.15 Identities = 35/136 (25%), Positives = 50/136 (36%), Gaps = 26/136 (19%) Query: 91 GDCRRFRGSLASLGSRGGGSGGTGSGSSH--------GHLHDSAEERRLIA--------- 133 G + F +LA G GG G G +H L +A+++ L+ Sbjct: 1104 GTPKLFNAALAMTGKMGG-KGAKGGKLAHLRARLKELAALEAAAKQQELVEQAKSSQDVK 1162 Query: 134 --EGDASPGEDRTPPGLAAEPERPGASAQPAASPP--PPQ----QPPQPASASCEQPSVD 185 EG A+P + P A +P P +P SPP PP +P E Sbjct: 1163 GEEGSAAPDQHTHPKEAATDPPAPRTPPEPPGSPPSSPPPASLGRPEGEEEGPAEPEEHS 1222 Query: 186 TAIKVEGGAAAGDQIL 201 I + G G+QIL Sbjct: 1223 VRICMSPGPEPGEQIL 1238 >gi|38569493 potassium voltage-gated channel, subfamily H (eag-related), member 3 [Homo sapiens] Length = 1083 Score = 153 bits (387), Expect = 8e-37 Identities = 224/938 (23%), Positives = 365/938 (38%), Gaps = 157/938 (16%) Query: 211 AGFMQRQFGAMLQPGVNKFSLRMFGSQKAV-EREQERVKSAGFWIIHPYSDFRFYWDLTM 269 +G +Q+Q G +K + +FG + + E + ++ + F ++H R WD + Sbjct: 178 SGHLQKQ-----PKGKHKLNKGVFGEKPNLPEYKVAAIRKSPFILLH-CGALRATWDGFI 231 Query: 270 LLLMVGNLIIIPVGITFFKDENTT----PWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTE 325 LL + + +P + + P V ++ + F++D+VLNFRT V + + Sbjct: 232 LLATLYVAVTVPYSVCVSTAREPSAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSG-Q 290 Query: 326 IILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVETRIDSEVYKTARALRIVRFTKILSL 385 ++ P+ I + Y+ +WF++D I+++P D + VY A L+ VR +L L Sbjct: 291 VVFAPKSICLHYVTTWFLLDVIAALPFDLLHAF-----KVNVYFGAHLLKTVR---LLRL 342 Query: 386 LRLL-RLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQ- 443 LRLL RL R +Y SAVV + L+ + LL HW C+ F + + Sbjct: 343 LRLLPRLDRYSQY---------------SAVV-LTLLMAVFALLAHWVACVWFYIGQREI 386 Query: 444 -----DFPDDCW--------------VSINNMVNNSWGKQ-------------------- 464 + P+ W V NS G+ Sbjct: 387 ESSESELPEIGWLQELARRLETPYYLVGRRPAGGNSSGQSDNCSSSSEANGTGLELLGGP 446 Query: 465 -----YSYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQS 519 Y +L+ A+S + +G+G + ++ ++ +M++GA +A+ G+ TA+IQ Sbjct: 447 SLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGALMHAVVFGNVTAIIQR 506 Query: 520 LDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQ-GKMFDEESILGELSEPLR 578 + + R Y + + + Y+ H++P +QR+ +Y++ + D +L L + LR Sbjct: 507 MYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTTELLQSLPDELR 566 Query: 579 EEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHG 638 +I + K V +PLF A + ++ LR PG+Y+I +G + +YF+ G Sbjct: 567 ADIA-MHLHKEVLQLPLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDALQALYFVCSG 625 Query: 639 VVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRAD----TYCRLYSLSVDNFNEVLE 694 + VL G L G G C L R + AD TYC L L + ++ L Sbjct: 626 SMEVLKGGTVLAILGKGDLIG--CELPRREQVVKANADVKGLTYCVLQCLQLAGLHDSLA 683 Query: 695 EYPMMRRAFETVALDRLDRIGKKNSILLHKVQHDLNSGVFNYQENEIIQQIVQHDREMAH 754 YP F + L ++ ++L +G E+ + D + Sbjct: 684 LYPEFAPRF--------------SRGLRGELSYNLGAG---GGSAEVDTSSLSGDNTLMS 726 Query: 755 CAHRVQAAASATPTPTPVIWTPLIQAPLQAAAATTSVAIALTHHPR----LPAAIFRPPP 810 + PT +P +PL + T+S + A PR P R P Sbjct: 727 TLEEKETDGEQGPTVSPAP-ADEPSSPLLSPGCTSSSSAAKLLSPRRTAPRPRLGGRGRP 785 Query: 811 GSG---LGNLGAGQTPRHLKRLQSLIPSALGSASPASSPSQVDTPSSSSFHIQQLAGFSA 867 G G PR L+ L+ +P + P SP VD Q FS Sbjct: 786 GRAGALKAEAGPSAPPRALEGLR--LPPMPWNVPPDLSPRVVDGIEDGCGSDQ--PKFSF 841 Query: 868 PAGLSPLLPSSSSSPPP--GACGSPSAPTPSAGV--------AATTIAGFGHFHKALGGS 917 G S SSS SP P G P P+ + A T ++ + S Sbjct: 842 RVGQSGPECSSSPSPGPESGLLTVPHGPSEARNTDTLDKLRQAVTELSEQVLQMREGLQS 901 Query: 918 LSSSDSPLLTPLQPGARSPQAAQPSPAPPGARGGL-------GLPEHFLPPPPSSRSPSS 970 L + +L P + G P+A+ P P G L G + L PP S + Sbjct: 902 LRQAVQLVLAPHREGP-CPRASGEGPCPASTSGLLQPLCVDTGASSYCLQPPAGSVLSGT 960 Query: 971 SPGQLGQPPGELSLGLATGPLSTPETP-PR---------QPEPPSLVAGASGGASPVGFT 1020 P PP L GP ++ +P PR EPP ASG T Sbjct: 961 WPHPRPGPP-PLMAPWPWGPPASQSSPWPRATAFWTSTSDSEPP-----ASGDLCSEPST 1014 Query: 1021 PRGGLSPPGHSPGPPRTFPSAPPRASGSHGSLLLPPAS 1058 P SPP G RT P+ P + + + PP S Sbjct: 1015 P---ASPPPSEEG-ARTGPAEPVSQAEATSTGEPPPGS 1048 Score = 32.0 bits (71), Expect = 3.6 Identities = 31/113 (27%), Positives = 47/113 (41%), Gaps = 7/113 (6%) Query: 94 RRFRGSLASLGSRGGGSG--GTGSGSSHGHLHDSAEERRLIAEGDASPGEDRTPPGLAAE 151 R RG L+ GGGS T S S L + EE+ +G+ P P + Sbjct: 694 RGLRGELSYNLGAGGGSAEVDTSSLSGDNTLMSTLEEKE--TDGEQGPTVSPAPADEPSS 751 Query: 152 PE-RPGASAQPAASP--PPPQQPPQPASASCEQPSVDTAIKVEGGAAAGDQIL 201 P PG ++ +A+ P + P+P +P A+K E G +A + L Sbjct: 752 PLLSPGCTSSSSAAKLLSPRRTAPRPRLGGRGRPGRAGALKAEAGPSAPPRAL 804 >gi|26051271 voltage-gated potassium channel, subfamily H, member 2 isoform b [Homo sapiens] Length = 888 Score = 152 bits (384), Expect = 2e-36 Identities = 104/418 (24%), Positives = 188/418 (44%), Gaps = 52/418 (12%) Query: 253 WIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTT------------PWIVFNV 300 W I YS F+ WD +LLL++ + P F E P V ++ Sbjct: 398 WTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDL 457 Query: 301 VSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVE 360 + D F++D+++NFRT V N E++ P RI + Y K WF++D +++IP D + Sbjct: 458 IVDIMFIVDILINFRT-TYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSG 516 Query: 361 TRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVN 420 + + KTAR LR+VR + +L R Y +AV+ + Sbjct: 517 SEELIGLLKTARLLRLVRVAR--------KLDRYSEY--------------GAAVLFL-- 552 Query: 421 LIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMVNNSWGKQYSY------------- 467 L+ L+ HW C+ + + ++ D + + + + GK Y+ Sbjct: 553 LMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYV 612 Query: 468 -ALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQ 526 AL+ S + +G+G +P S+ ++ M++G+ YA G+ +A+IQ L S + Sbjct: 613 TALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTAR 672 Query: 527 YQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQ-GKMFDEESILGELSEPLREEIINFN 585 Y + +V +++ FH++P RQR+ +Y++H + D ++L E L+ +I Sbjct: 673 YHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHL 732 Query: 586 CRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVL 643 R L+ F A + ++ K + PGD ++ G + +YFI G + +L Sbjct: 733 NRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEIL 790 >gi|27886646 potassium voltage-gated channel, subfamily H, member 5 isoform 3 [Homo sapiens] Length = 611 Score = 150 bits (379), Expect = 7e-36 Identities = 112/433 (25%), Positives = 192/433 (44%), Gaps = 46/433 (10%) Query: 235 GSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTP 294 GS + +QE K+ I+H Y F+ WD +L+L I++P ++F +N Sbjct: 188 GSDILPQYKQEAPKTPPHIILH-YCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIA 246 Query: 295 WIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDY 354 W+V + V D FL+D+VLNF T V E+I DP+ I+M YLK+WF++D +S +P D Sbjct: 247 WLVLDSVVDVIFLVDIVLNFHT-TFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDI 305 Query: 355 IFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASA 414 I +D + +L++V RLLRL R+ R + + E A+ Sbjct: 306 INAF--ENVDEGISSLFSSLKVV---------RLLRLGRVARKLDHYLEYG------AAV 348 Query: 415 VVRIVNLIGMMLLLCHWDGCLQFLV-------PMLQDFPDDCW-------VSINNMVNNS 460 +V +V + G L+ HW C+ + + + D W + N S Sbjct: 349 LVLLVCVFG---LVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTS 405 Query: 461 WG---------KQYSYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIG 511 G Y +L+ M+ + IG+G AP + ++ M+VG+ YA G Sbjct: 406 AGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFG 465 Query: 512 HATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRY-QGKMFDEESIL 570 + T + Q + ++ +Y E V ++ +++P +R+ DY + K D E +L Sbjct: 466 NVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVL 525 Query: 571 GELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGK 630 + +R +I RK+ P F A + ++ + + PGD I G Sbjct: 526 SICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVD 585 Query: 631 KMYFIQHGVVSVL 643 + F+ G + V+ Sbjct: 586 ALCFVVSGSLEVI 598 >gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens] Length = 809 Score = 140 bits (352), Expect = 9e-33 Identities = 115/463 (24%), Positives = 205/463 (44%), Gaps = 52/463 (11%) Query: 255 IHPYSDFRFY--WDLTMLLLMVGNLIIIPVGITFFKD--ENTTPWIVFNVVSDTFFLIDL 310 I Y+D R Y W L + L N IP+ + F +N W++ +++ D +L D+ Sbjct: 210 IDSYTD-RLYLLWLLLVTLAYNWNCCFIPLRLVFPYQTADNIHYWLIADIICDIIYLYDM 268 Query: 311 VLNFRTGIVVEDNTEIILDPQRIKMKYLKSW-FMVDFISSIPVDYIFLIVETRIDSEVYK 369 + + + +II+D ++ Y S F +D S IP D +L Sbjct: 269 LF-IQPRLQFVRGGDIIVDSNELRKHYRTSTKFQLDVASIIPFDICYLFFG--------- 318 Query: 370 TARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLC 429 F + R+L+ + + H E I Y + R++ G +L + Sbjct: 319 ---------FNPMFRANRMLKYTSFFEFNHHLESIMDKAY-----IYRVIRTTGYLLFIL 364 Query: 430 HWDGCLQFLVPMLQDFPDDCWVSINNMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPVGM 489 H + C+ + + WV + G +Y + A+ ++ IG G P + Sbjct: 365 HINACVYYWASNYEGIGTTRWVY------DGEGNEYLRCYYWAVRTLITIG-GLPEPQTL 417 Query: 490 SDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQ 549 ++ +L+ G ++ IG +I + +++ ++ YM+ + +P ++ Sbjct: 418 FEIVFQLLNFFSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTIAYMNNYSIPKLVQK 477 Query: 550 RIHDYYEHRYQG-KMFDEESILGELSEPLREEI---INFNCRKLVASMPLFANADPNFVT 605 R+ +YE+ + +M DE +L L ++ + +NF+ +++ + LF D + Sbjct: 478 RVRTWYEYTWDSQRMLDESDLLKTLPTTVQLALAIDVNFS---IISKVDLFKGCDTQMIY 534 Query: 606 SMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETK----LADGSYFGEI 661 ML +L+ ++ PGD++ ++G IGK+MY I+HG V VL G TK L GS FGEI Sbjct: 535 DMLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGEVQVL-GGPDGTKVLVTLKAGSVFGEI 593 Query: 662 CLLTRG---RRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRR 701 LL G RRTA+V A + L +L E+L YP R Sbjct: 594 SLLAAGGGNRRTANVVAHGFANLLTLDKKTLQEILVHYPDSER 636 >gi|27886665 potassium voltage-gated channel, subfamily H, member 7 isoform 2 [Homo sapiens] Length = 732 Score = 136 bits (342), Expect = 1e-31 Identities = 92/334 (27%), Positives = 163/334 (48%), Gaps = 49/334 (14%) Query: 252 FWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDE-----------NTTPWIVFNV 300 F I+H YS F+ WD +LLL++ I P F ++ + +P V ++ Sbjct: 391 FTILH-YSPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDL 449 Query: 301 VSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVE 360 + D F+ID+++NFRT V N E++ DP +I + Y K WF++D +++IP D LI Sbjct: 450 IVDIMFIIDILINFRT-TYVNQNEEVVSDPAKIAIHYFKGWFLIDMVAAIPFD--LLIFG 506 Query: 361 TRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVN 420 + D T ++ LL+ RL RL+R + + Y A V ++ Sbjct: 507 SGSDET-------------TTLIGLLKTARLLRLVRVARKLDR-----YSEYGAAVLML- 547 Query: 421 LIGMMLLLCHWDGCLQFLV-----PMLQD---FPDDCWVSINNMVNNSWGK-------QY 465 L+ + L+ HW C+ + + P L D + D I N+S +Y Sbjct: 548 LMCIFALIAHWLACIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKY 607 Query: 466 SYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRR 525 AL+ S + +G+G +P S+ ++ M++G+ YA G+ +A+IQ L S Sbjct: 608 VTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTA 667 Query: 526 QYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRY 559 +Y + +V++++ FH++P RQR+ +Y++H + Sbjct: 668 RYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAW 701 >gi|163965366 nascent polypeptide-associated complex alpha subunit isoform a [Homo sapiens] Length = 2078 Score = 92.8 bits (229), Expect = 2e-18 Identities = 125/490 (25%), Positives = 167/490 (34%), Gaps = 91/490 (18%) Query: 760 QAAASATPTPTPVIWTPLIQAPLQAAAATTSVAIALTHHPRLPAAIFRPPPGSGLGNLGA 819 + + +ATP P TP P T +L P PAA P G Sbjct: 1044 KGSPAATPLPKGAPTTPAATLPSPKGGPATP---SLKGAPTPPAATPPSPKGGPATPSPK 1100 Query: 820 GQ------TPRHLKRLQSLIPSALGSASPASSPSQVDTPSSSSFHIQQLAGFSAPAGLSP 873 G TP K + P +PA++P +P + PA P Sbjct: 1101 GAPMPPAATPPSPKGGLATPPHKGAPTTPAATPP---SPKGGLATPPPKGAPTTPAATPP 1157 Query: 874 LLPSSSSSPPP-GACGSPSA--PTPSAGVAATTIAGFGHFHKALGGSLSSSDSPLLTPLQ 930 ++PPP GA +P+A P+P G+A + G + +P TP Sbjct: 1158 SPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKG-------------APTTPAATPPS 1204 Query: 931 P----GARSPQAAQPSPA--PPGARGGLGLPEHFLPPPPSSRSPSSSPGQLGQPPGELSL 984 P SP+ A +PA PP +GGL P P + +P S G PP + Sbjct: 1205 PKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPK--- 1261 Query: 985 GLATGPLSTPE-------TPPRQPEP-PSLVAGASGGASPVGFTPRGGLSPPGHSPGPPR 1036 G T P +TP TPP + P P++V S P P+G +PP +P P+ Sbjct: 1262 GAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPK 1321 Query: 1037 TFPSAPPRASGSHGSLLLPPASSPPPPQ--------VPQRRGTPPL-------TPGRLTQ 1081 P PP PPA +PP P+ P +G P TP T Sbjct: 1322 GSPGTPPPKGAP-----TPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATP 1376 Query: 1082 DLKLISASQPALPQDGAQTLRRASPHSSGESMAAFPLFPRAGGGS------GGSGSSGGL 1135 K A P P+ G SP S A PL P+ + + S G L Sbjct: 1377 SHKGGPAMTPPSPKRGPAI---PSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDL 1433 Query: 1136 GPP-----------------GRPYGAIPGQHVTLPRKTSSGSLPPPLSLFGARATSSGGP 1178 PP G P TLP T PP A ++S Sbjct: 1434 TPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKA 1493 Query: 1179 PLTAGPQREP 1188 P T P P Sbjct: 1494 PATPAPMGAP 1503 Score = 83.2 bits (204), Expect = 1e-15 Identities = 128/490 (26%), Positives = 174/490 (35%), Gaps = 108/490 (22%) Query: 764 SATPTPTPVIWTPLIQAPLQ--AAAATTSVAIALTHHPRLPAAIF--------RPP---- 809 S T PV +P + P + A+AT S LT+ P+ + RPP Sbjct: 755 SHTSALAPVASSPK-ECPTEDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPPTKKG 813 Query: 810 ---PGSGLGNLGAGQTPRHLKRLQSLIPSALGSA-SPASSPSQVDTPSSSSFHIQQLAGF 865 P + +GNL + +P L S GS SPA++ S TP S G Sbjct: 814 SAGPDTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSP--TPPSPK-------GA 864 Query: 866 SAPAGLSPLLPSSSSSPP-----------PGACGSPSAPTPSAGVAATTIAGFGHFHKAL 914 P+ ++PL P + PP P P+ P P A + + +A Sbjct: 865 PTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARAT 924 Query: 915 GG--SLSSSDSPLLTPLQPGARSPQA----AQPSP---------APPGARGGLGLPEHFL 959 + +S SP P P A P A PSP PP +GG P Sbjct: 925 PAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKG 984 Query: 960 PPPPSSRSPSSSPGQLGQPPGELSLGLATGPLSTPETPPRQPEPPSLVAGASGGASPVGF 1019 P P + +P S G P + G T P TP +P P A+P Sbjct: 985 APTPPAATPPSPKGGPATPSPK---GAPTPPAVTPPSPKGSP-----------AATPF-- 1028 Query: 1020 TPRGGLSPPGHSPGPPRTFPSAPPRASGSHGSLLLPPASSPPP---PQVPQRRGTPPLTP 1076 P+G +PP +P P+ P+A P G+ + P A+ P P P P +G P TP Sbjct: 1029 -PKGASTPPAATPPSPKGSPAATPLPKGAPTT---PAATLPSPKGGPATPSLKGAP--TP 1082 Query: 1077 GRLTQDLKLISASQPALPQDGAQTLRRASPHSSGESMAAFPLFPRAG------------G 1124 A+ P P+ G T SP + AA P P+ G Sbjct: 1083 ----------PAATPPSPKGGPAT---PSPKGAPMPPAATPPSPKGGLATPPHKGAPTTP 1129 Query: 1125 GSGGSGSSGGLGPPGRPYGAIPGQHVTLPRKTSSGSLPPPLSLFGARATSSGGPPLTAGP 1184 + GGL P P GA T P + PPP GA T + PP G Sbjct: 1130 AATPPSPKGGLATP-PPKGAPTTPAATPPSPKGGLATPPPK---GAPTTPAATPPSPKGG 1185 Query: 1185 QREPGARPEP 1194 P + P Sbjct: 1186 LATPSPKGAP 1195 Score = 78.6 bits (192), Expect = 3e-14 Identities = 123/467 (26%), Positives = 172/467 (36%), Gaps = 83/467 (17%) Query: 765 ATPTPTPVIWTPLIQAPL-QAAAATTSVAIALTHHPRLPAAIFRPPPGSGLGNLGAGQTP 823 ATP+P P P + AT S A T P A+ P P G+ A P Sbjct: 978 ATPSPKGAPTPPAATPPSPKGGPATPSPKGAPT-----PPAVTPPSPK---GSPAATPFP 1029 Query: 824 RHLKRLQSLIPSALGSASPASSPSQVDTPSSSSFHIQQLAGFSAPAGLSPLLPSSSSSPP 883 + + P + SPA++P P++ + + G A L P+ ++ P Sbjct: 1030 KGASTPPAATPPS-PKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGA-PTPPAATP 1087 Query: 884 PGACGSPSAPTPSAGV---AATTIAGFGHFHKALGGSLSSSDSPLLTPLQP----GARSP 936 P G P+ P+P AAT + G A + +P TP P P Sbjct: 1088 PSPKGGPATPSPKGAPMPPAATPPSPKGGL--ATPPHKGAPTTPAATPPSPKGGLATPPP 1145 Query: 937 QAAQPSPA--PPGARGGLGLPEHFLPP------PPSSRSPSSSPGQLGQP------PGEL 982 + A +PA PP +GGL P P PPS + ++P G P P Sbjct: 1146 KGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSP 1205 Query: 983 SLGLAT----GPLSTPETPPRQPEPPSLVAGASGGASPVGFTPRGGLSPPGHSPGPPRTF 1038 GLAT G +TP P P+ G A+P +P+G + P +P P+ Sbjct: 1206 KGGLATPSPKGAPTTPAATPPSPK--------GGLATP---SPKGAPTTPAATPPSPKGG 1254 Query: 1039 PSAPPRASGSHGSLLLPPASSPPPPQ----VPQRRGTPPLTPGRLTQDLKLISASQPALP 1094 P+ PP PPA++PP + P +G P P +T P P Sbjct: 1255 PATPPPKGAP-----TPPAATPPSLKGGLATPPHKGAP--NPAVVT----------PPSP 1297 Query: 1095 QDGAQTLRRASPHSSGESMAAFPLFPRAGGGSGGSGSSGGLGPPGRPYGAIPGQHVTLPR 1154 + G T + P + AA P P+ GS G+ G P P TLP Sbjct: 1298 KGGPAT---SPPKGAPTPPAATPPSPK---GSPGTPPPKGAPTPPAVTPPSPKGTPTLPA 1351 Query: 1155 KT--SSGSLPPPLSLFG-----ARATSSGGPPLTAGPQREPGARPEP 1194 T S G P S G A + GGP +T + A P P Sbjct: 1352 TTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSP 1398 Score = 67.0 bits (162), Expect = 1e-10 Identities = 112/439 (25%), Positives = 156/439 (35%), Gaps = 109/439 (24%) Query: 832 LIPSALGSASPASSPSQVDTPSSSSFHIQQLAGFSAPAGLSPLLPSSSSSP-------PP 884 L+P+A + A SP P ++ L+P +P S SP PP Sbjct: 700 LVPTASENCPVAPSPQNTCAPLATLV-------------LAPEIPKSVPSPSLPPAGTPP 746 Query: 885 G----------------ACGSPSAPTPSAGVAATTIAGFGHFHKALGGSLSSSDSPLLTP 928 G A PT +G +AT + K L+ S SPL Sbjct: 747 GTKKVDGISHTSALAPVASSPKECPTEDSGASATASS------KGTLTYLADSPSPLGVS 800 Query: 929 LQPGARSPQAAQPSPAPPGARGGLG----------LPEHFL--------------PPPPS 964 + P + P + S P G L LPE+ L P PPS Sbjct: 801 VSPQTKRPPTKKGSAGPDTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPS 860 Query: 965 SR---SPSS----SPGQLGQPPGEL---SLGLATGPLSTPETP-PRQPEPPSLVAGASGG 1013 + +PS+ SP + PP E S+ P P TP P+Q S+ + + Sbjct: 861 PKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKK 920 Query: 1014 AS--------PVGFTPRGGLSPPGHSPGPPRTFPSAP-PRASGSHGSLLLPPASSPPPPQ 1064 A P +P+G +PP +P P+ P+ P P+ + + PPA++PP P+ Sbjct: 921 ARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPT------PPAATPPSPK 974 Query: 1065 ----VPQRRGTPPLTPGRLTQDLKLISASQPALPQ-DGAQTLRRASPHSSGESMAAFPLF 1119 P +G P TP T PA P GA T +P S S AA P F Sbjct: 975 GGPATPSPKGAP--TPPAATPP---SPKGGPATPSPKGAPTPPAVTPPSPKGSPAATP-F 1028 Query: 1120 PRAGGGSGGSGSSGGLGPPGR---PYGAIPGQHVTLPRKTSSGSLPPPLSLFGARATSSG 1176 P+ + G P P GA TLP + P SL GA + Sbjct: 1029 PKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATP---SLKGAPTPPAA 1085 Query: 1177 GPPLTAGPQREPGARPEPV 1195 PP G P + P+ Sbjct: 1086 TPPSPKGGPATPSPKGAPM 1104 Score = 63.9 bits (154), Expect = 9e-10 Identities = 82/349 (23%), Positives = 116/349 (33%), Gaps = 44/349 (12%) Query: 765 ATPTPTPVIWTPLIQAPL-QAAAATTSVAIALTHHPRLPAAI---FRPPPGSGLGNLGAG 820 ATP+P TP P + AT A T P ++ PP G N Sbjct: 1233 ATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVV 1292 Query: 821 QTPRHLKRLQSLIPSALGSASPASSPSQVDTPSSSSFHIQQLAGFSAPAGLSPLLPSSSS 880 P + P + A+ PS +P + G P ++P P + Sbjct: 1293 TPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPP-----PKGAPTPPAVTPPSPKGTP 1347 Query: 881 SPPPGACGSPSAPTPSAGVAATTIAGFGHFHKALGGSLSSSDSPLLTPLQPGARS----- 935 + P S PT + T HK GG + SP P P + Sbjct: 1348 TLPATTPSSKGGPTTPSSKEGPTPPAATPSHK--GGPAMTPPSPKRGPAIPSPKGDPTSP 1405 Query: 936 ---PQAAQPSPAPPGARGGLGLPEH--FLPP---PPSSRSPSSSPGQLGQPPGELSLGLA 987 P + + +PA P R G P PP P S + ++ G P S G Sbjct: 1406 AVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDP 1465 Query: 988 TGPLSTPETPPRQPEPPSLVAGASGGASPVGFTPRGGLSPPGHSPGPPRTFPSAPPR--- 1044 T P TP +P P P + +S +P P G + P P P+ P+ P Sbjct: 1466 TLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRD 1525 Query: 1045 --------------ASGSHGSLLLPPASSPPPPQVPQRRGTP---PLTP 1076 A+ + L+PPA + P P+ TP P TP Sbjct: 1526 PIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATP 1574 Score = 63.9 bits (154), Expect = 9e-10 Identities = 96/421 (22%), Positives = 142/421 (33%), Gaps = 57/421 (13%) Query: 808 PPPGSGLGNLGAGQTPRHLKRLQSLIPSALGSASPASSPSQVDTPSSSSFHIQQLAGFSA 867 PP G+ +P+ L + PS+ G + SS P+++ H A Sbjct: 1328 PPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPP 1387 Query: 868 PAGLSPLLPSSSSSPPPGACGSPSAPTPSAGVAATTIAGFGHFHKALGGSLSSSDSPLLT 927 P +PS P A P AT + G + G + +P+ Sbjct: 1388 SPKRGPAIPSPKGDPTSPAV----IPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSL 1443 Query: 928 PLQPGARSPQAAQPSPAPPGARGGLGLP-----EHFLPPPPSSRSPSSSPGQLGQPPGEL 982 P +P+ PA P ++G LP PP P + SSSP + P + Sbjct: 1444 KKAPATSAPKGG---PATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPM 1500 Query: 983 SLG-----LATGPLSTPETPPRQPEPPSLVAGASGGASPVGFTPRGGLSPPGHSPGPPRT 1037 + + P P TP + +P + A +P P+ L PP + P+ Sbjct: 1501 GAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKK 1560 Query: 1038 FP-----------------SAPP-------RASGSHGSLLLPPA-SSPPPPQVPQRRGTP 1072 P S+PP + + S LL+PPA +SP P + P Sbjct: 1561 TPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVT 1620 Query: 1073 PLTP--GRLTQDLKLISASQPALPQDGAQTLRRASPHSSGESMAAFPLFPRAGGGSGGSG 1130 P +P G T K S P P + SP S M A P+A G Sbjct: 1621 PPSPEKGPATPAPKGTPTSPPVTPSSLKDS--PTSPASVTCKMGA--TVPQASKGLPAKK 1676 Query: 1131 SSGGL-------GPPGRPYGAIPGQHVTLPRKTSSGSLPPPLSLFGARATSSGGPPLTAG 1183 L P P P + +K+S+ S PP+ + S GP T Sbjct: 1677 GPTALKEVLVAPAPESTPIITAPTRKGPQTKKSSATS--PPICPDPSAKNGSKGPLSTVA 1734 Query: 1184 P 1184 P Sbjct: 1735 P 1735 Score = 58.9 bits (141), Expect = 3e-08 Identities = 90/365 (24%), Positives = 132/365 (36%), Gaps = 74/365 (20%) Query: 760 QAAASATPTPTPVIWTPLIQAPLQAAAATTSVAIALTHHPRLPAAIFRPPPGSGLGNLGA 819 Q A S++P P TP AP+ A + + P P++ R P + L + Sbjct: 1483 QVATSSSPKKAPA--TP---APMGAPTLPAVIPSSPKEVPATPSS--RRDPIAPTATLLS 1535 Query: 820 GQTPRHLKRLQSLIPSALGSASPASSPSQVDTP-----------SSSSFHIQQLAGFSAP 868 +TP L ++LIP A+ SP +P+ + TP +SS + AP Sbjct: 1536 KKTPATLAPKEALIPPAMTVPSPKKTPA-IPTPKEAPATPSSKEASSPPAVTPSTYKGAP 1594 Query: 869 AGLSPLLPSSSSSPPPGACGSPSA---PTPSAGVAATTIAGFGHFHKALGGSLSSSD-SP 924 + L+P + +SP P +P A P+P G A G SL S SP Sbjct: 1595 SPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSP 1654 Query: 925 LLTPLQPGARSPQAAQPSPAPPGARGGLGLPEHFLPPPPSSRSPSSSPGQLGQP------ 978 + GA PQA++ PA +G L E + P P S ++P + G Sbjct: 1655 ASVTCKMGATVPQASKGLPAK---KGPTALKEVLVAPAPESTPIITAPTRKGPQTKKSSA 1711 Query: 979 ------PGELSLGLATGPLSTPETPPRQPEPPSLVAGASGGASPVGFTPRGGLSPP---- 1028 P + + GPLST P P A G +P+G L+PP Sbjct: 1712 TSPPICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKG--KDASHSPKGPLAPPESKA 1769 Query: 1029 ---------------------GHSPGPPRTFP-------SAPPRAS--GSHGSLLLPPAS 1058 +P PP + P + PP+ S L+L S Sbjct: 1770 STPLTAAAFEKVLPKPESASVSAAPSPPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPS 1829 Query: 1059 SPPPP 1063 P P Sbjct: 1830 KPLAP 1834 Score = 47.0 bits (110), Expect = 1e-04 Identities = 81/320 (25%), Positives = 116/320 (36%), Gaps = 66/320 (20%) Query: 761 AAASATPTPTPVIWTPLIQAPLQAAAATTSVAIALTHHPRLPAAIFRPP-PGSGLGN-LG 818 + +A P P + P AP Q + + A + + P P S G L Sbjct: 33 SVTAALGQPGPTLPPPCSPAPQQCPLSAANQASPFPSPSTIASTPLEVPFPQSSSGTALP 92 Query: 819 AGQTPRHLKRLQSLI-----PSALGSASPASSPSQVDTPSSSSFHIQQLAGFSAPAGLSP 873 G P L +LI P+AL ASP +P+ TPSS SAP L Sbjct: 93 LGTAPEAPTFLPNLIGPPISPAALALASPMIAPTLKGTPSS-----------SAPLALVA 141 Query: 874 LLPSS---SSSPPPGACGSPSAPTPSAGVAATTIAGFGHFHKALGGSLSSSDSPLLTPLQ 930 L P S SS+ PP SP PS VA + GS+ + +P + P + Sbjct: 142 LAPHSVQKSSAFPPNLLTSP----PSVAVAES-------------GSVITLSAP-IAPSE 183 Query: 931 PGARSPQAAQPSPAPPGARGGLGLPEHFLPPPPSSRSPSSSPGQLGQPPGELSLGLATGP 990 P + PS P +G P PP S+ P P + G+A+ P Sbjct: 184 PKTNLNKV--PSEVVPNPKG--------TPSPPC--IVSTVPYHCVTPMASIQSGVASLP 231 Query: 991 LSTPET----PPRQPEPPSLVAGASGGASPVGFTPRGGLSPPGH-----------SPGPP 1035 +TP T Q + ++ + +P + +G +SPP + Sbjct: 232 QTTPTTTLAIASPQVKDTTISSVLISPQNPGSLSLKGPVSPPAALSLSTQSLPVVTSSQK 291 Query: 1036 RTFPSAPPRASGSHGSLLLP 1055 P+ PP S GS L P Sbjct: 292 TAGPNTPPDFPISLGSHLAP 311 Score = 40.8 bits (94), Expect = 0.008 Identities = 73/294 (24%), Positives = 101/294 (34%), Gaps = 62/294 (21%) Query: 931 PGARSPQAAQPSPAPPGARGGLGLPEHFLPPPPS------------SRSPSSSPGQLGQP 978 P ++ A P + LG P LPPP S SP SP + Sbjct: 17 PQPQAETAVLPMSSALSVTAALGQPGPTLPPPCSPAPQQCPLSAANQASPFPSPSTIAST 76 Query: 979 PGEL-----SLGLATGPLSTPETPPRQPE---PP--------------SLVAGASGGASP 1016 P E+ S G A + PE P P PP + G ++P Sbjct: 77 PLEVPFPQSSSGTALPLGTAPEAPTFLPNLIGPPISPAALALASPMIAPTLKGTPSSSAP 136 Query: 1017 VGFTPRGGLSPPGHSPGPPRTFPSAPPRA---SGSHGSLLLPPASSPPPPQ--------V 1065 + S S PP S P A SGS +L P A S P V Sbjct: 137 LALVALAPHSVQKSSAFPPNLLTSPPSVAVAESGSVITLSAPIAPSEPKTNLNKVPSEVV 196 Query: 1066 PQRRGTP------PLTPGRLTQDLKLISASQPALPQ-DGAQTLRRASPHSSGESMAAFPL 1118 P +GTP P + I + +LPQ TL ASP ++++ + Sbjct: 197 PNPKGTPSPPCIVSTVPYHCVTPMASIQSGVASLPQTTPTTTLAIASPQVKDTTISSVLI 256 Query: 1119 FPRAGGGSGGSGSSGGLGPPGR---PYGAIPGQHVTLPRKTSSGSLPP--PLSL 1167 P+ G G + PP ++P VT +KT+ + PP P+SL Sbjct: 257 SPQ---NPGSLSLKGPVSPPAALSLSTQSLP--VVTSSQKTAGPNTPPDFPISL 305 Score = 36.2 bits (82), Expect = 0.19 Identities = 40/172 (23%), Positives = 57/172 (33%), Gaps = 19/172 (11%) Query: 52 PLPSPSPSAAAGGTESRSSALGAADSEGPARGAGKSSTNGDCRRFRGSLASLGSRGGGSG 111 P P +P+ A S+ + EGP A S G S + G Sbjct: 1341 PSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKG 1400 Query: 112 GTGSGSSHGHLHDSAEERRLIAEGDASPGE-DRTPPGLA-----------------AEPE 153 S + A + EG A+P + D TPP + A P Sbjct: 1401 DPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPS 1460 Query: 154 RPGASAQPAASPPPPQQPPQPAS-ASCEQPSVDTAIKVEGGAAAGDQILPEA 204 G PA +PP P++PP P A+ P A GA ++P + Sbjct: 1461 SKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSS 1512 Score = 35.4 bits (80), Expect = 0.33 Identities = 51/189 (26%), Positives = 69/189 (36%), Gaps = 25/189 (13%) Query: 765 ATPTPTPVIWTPLIQAPLQAAAATTSVAIALTHHPRLPAAIFRPPPGSGLGNLGAGQTPR 824 +T P P++ P+Q ++ T+ +H P+ P A PP L A + Sbjct: 1731 STVAPAPLL-------PVQKDSSKTAKGKDASHSPKGPLA---PPESKASTPLTAAAFEK 1780 Query: 825 HLKRLQSLIPSALGSAS----------PASSPSQVDTPSSSSFHIQQLAGFSAPAGLSPL 874 L + +S SA S P P Q PSS ++ + APA L Sbjct: 1781 VLPKPESASVSAAPSPPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPSKPLAPADEDEL 1840 Query: 875 LPSSSSSPPPGACGSPSA----PTP-SAGVAATTIAGFGHFHKALGGSLSSSDSPLLTPL 929 LP P G S PTP SAG+ T + K GS + SDS P Sbjct: 1841 LPLIPPEPISGGVPFQSVLVNMPTPKSAGIPVPTPSAKQPVTKNNKGSGTESDSDESVPE 1900 Query: 930 QPGARSPQA 938 S QA Sbjct: 1901 LEEQDSTQA 1909 Score = 34.3 bits (77), Expect = 0.73 Identities = 19/52 (36%), Positives = 24/52 (46%), Gaps = 1/52 (1%) Query: 145 PPGLAAEPERPGASAQPAASPPPPQ-QPPQPASASCEQPSVDTAIKVEGGAA 195 P G+ A P GA PAA+PP P+ P P+ P T +GG A Sbjct: 927 PKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPA 978 Score = 33.5 bits (75), Expect = 1.3 Identities = 19/53 (35%), Positives = 24/53 (45%), Gaps = 1/53 (1%) Query: 144 TPPGLAAEPERPGASAQPAASPPPPQ-QPPQPASASCEQPSVDTAIKVEGGAA 195 +P G A P GA PAA+PP P+ P P+ P T +GG A Sbjct: 1066 SPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLA 1118 Score = 33.5 bits (75), Expect = 1.3 Identities = 19/53 (35%), Positives = 24/53 (45%), Gaps = 1/53 (1%) Query: 144 TPPGLAAEPERPGASAQPAASPPPPQ-QPPQPASASCEQPSVDTAIKVEGGAA 195 +P G A P GA PAA+PP P+ P P P T ++GG A Sbjct: 1227 SPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLA 1279 Score = 32.0 bits (71), Expect = 3.6 Identities = 19/54 (35%), Positives = 24/54 (44%), Gaps = 1/54 (1%) Query: 144 TPPGLAAEPERPGASAQPAASPPPPQ-QPPQPASASCEQPSVDTAIKVEGGAAA 196 +P G A P GA PAA+PP P+ P P+ P T +G AA Sbjct: 972 SPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAA 1025 >gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens] Length = 416 Score = 85.5 bits (210), Expect = 3e-16 Identities = 96/351 (27%), Positives = 118/351 (33%), Gaps = 57/351 (16%) Query: 864 GFSAPAGLSPLLPSSSSSPPPGACGSPSAPTPSAGVAATTIAGFGHFHKALGGSLSSSDS 923 G + P G P P PPP P P P G S S Sbjct: 64 GGNQPQGPPPP-PGKPQGPPPQGGNKPQGPPPPGKPQGPPPQG------------DKSRS 110 Query: 924 PLLTPLQPGARSPQAA---QPSPAPPGARGGLGLPEHFLPPPPSSRSPSSSPGQ---LGQ 977 P P +P PQ Q P PPG G PPP P P G Sbjct: 111 PRSPPGKPQGPPPQGGNQPQGPPPPPGKPQG--------PPPQGGNKPQGPPPPGKPQGP 162 Query: 978 PP-GELSLGLATGPLSTPETPP----RQPEPPSLVAGASGGASPVGFTPRGGLSPPGHSP 1032 PP G+ + P P+ PP QP+ P G G P G G PPG Sbjct: 163 PPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQ 222 Query: 1033 GPP-------RTFPSAPPRASGSHGSLLLPPASSPPPPQVPQRRGTPPLTPGRLTQDLKL 1085 GPP ++ S P + G P PPPP PQ PP G Q Sbjct: 223 GPPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQ---GPPPQGGNKPQGPPP 279 Query: 1086 ISASQPALPQDGAQTLRRASPHSSGESMAAFPLFPRAGGGSGGSGSSGGLGPPGRPYGAI 1145 Q PQ G+++ SP P P+ GG+ G PPG+P G Sbjct: 280 PGKPQGPPPQGGSKSRSSRSP----------PGKPQGPPPQGGNQPQGPPPPPGKPQGPP 329 Query: 1146 P--GQHVTLPRKTSSGSLPPPLSLFGARATSSGGPP-LTAGPQREPGARPE 1193 P G P PPP G+++ S+ PP GP ++ G P+ Sbjct: 330 PQGGNKPQGPPPPGKPQGPPPQG--GSKSRSARSPPGKPQGPPQQEGNNPQ 378 Score = 64.7 bits (156), Expect = 5e-10 Identities = 81/292 (27%), Positives = 92/292 (31%), Gaps = 33/292 (11%) Query: 808 PPPGSGLGNLGAGQTPRHLKRLQSLIPSALGSASPASSPSQVDTPSSSSFHIQQLAGFSA 867 PPPG G P+ + Q P P P Q D S SS Sbjct: 134 PPPGKP-----QGPPPQGGNKPQGPPPPG----KPQGPPPQGDNKSRSSRSPPGKPQGPP 184 Query: 868 PAGLS-----PLLPSSSSSPPPGACGSPSAPTPSAGVAATTIAGFGHFHKALGGSLSSSD 922 P G + P P PPP P P P G A Sbjct: 185 PQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQG 244 Query: 923 SPLLTPLQPGARSPQAAQPS-PAPPGARGGLGLPEHFLP--PPPS----SRSPSSSPGQL 975 P QP P +P P P G G P P PPP SRS S PG+ Sbjct: 245 PPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGKP 304 Query: 976 GQPP---GELSLGLATGPLSTPETPPRQ----PEPPSLVAGASGGASPVGFTPRGGLSPP 1028 PP G G P P+ PP Q P+ P G G R SPP Sbjct: 305 QGPPPQGGNQPQGPPPPP-GKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARSPP 363 Query: 1029 GHSPGPPRTFPS----APPRASGSHGSLLLPPASSPPPPQVPQRRGTPPLTP 1076 G GPP+ + PP A G+ PPA P P P + G P P Sbjct: 364 GKPQGPPQQEGNNPQGPPPPAGGNPQQPQAPPAGQPQGPPRPPQGGRPSRPP 415 Score = 60.8 bits (146), Expect = 7e-09 Identities = 79/292 (27%), Positives = 97/292 (33%), Gaps = 68/292 (23%) Query: 914 LGGSLSSSDSPLLTPLQPGARSPQAA---QPSPAPPGARGGLGLPEHFLPPPPSSRSPSS 970 L +S +SP L P PQ Q P+PPG G PPP P Sbjct: 19 LNEDVSQEESPSLIAGNPQGAPPQGGNKPQGPPSPPGKPQG--------PPPQGGNQPQG 70 Query: 971 SPGQLGQPPGELSLGLATGPLSTPETPPRQPEPPSLVAGASGGASPVGFTPRGGLSPPGH 1030 P PPG+ P+ PP Q GG P G PPG Sbjct: 71 PP----PPPGK------------PQGPPPQ-----------GGNKPQG------PPPPGK 97 Query: 1031 SPGPP------RTFPSAPPRASGSHGSLLLPPASSPPPPQVPQRRGTPPLTPGRLTQDLK 1084 GPP R+ S P + G P PPPP PQ PP G Q Sbjct: 98 PQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQ---GPPPQGGNKPQGPP 154 Query: 1085 LISASQPALPQDGAQTLRRASPHSSGESMAAFPLFPRAGGGSGGSGSSGGLGPPGRPYGA 1144 Q PQ ++ SP P P+ GG+ G PPG+P G Sbjct: 155 PPGKPQGPPPQGDNKSRSSRSP----------PGKPQGPPPQGGNQPQGPPPPPGKPQGP 204 Query: 1145 IP--GQHVTLPRKTSSGSLPPPLSLFGARATSSGGPP-LTAGPQREPGARPE 1193 P G P PPP ++ S+ PP GP + G +P+ Sbjct: 205 PPQGGNKPQGPPPPGKPQGPPPQG--DNKSQSARSPPGKPQGPPPQGGNQPQ 254 Score = 58.9 bits (141), Expect = 3e-08 Identities = 63/209 (30%), Positives = 76/209 (36%), Gaps = 37/209 (17%) Query: 1000 QPEPPSLVAGASGGASPVGFT-PRGGLSPPGHSPGPPRTFPSAPPRASGSHGSLLLPPAS 1058 Q E PSL+AG GA P G P+G SPPG GP PP+ P Sbjct: 25 QEESPSLIAGNPQGAPPQGGNKPQGPPSPPGKPQGP-------PPQGGNQ-------PQG 70 Query: 1059 SPPPPQVPQRRGTPPLTPGRLTQDLKLISASQPALPQDGAQTLRRASPHSSGESMAAFPL 1118 PPPP PQ PP G Q Q PQ R+ P Sbjct: 71 PPPPPGKPQ---GPPPQGGNKPQGPPPPGKPQGPPPQGDKSRSPRSPPGK---------- 117 Query: 1119 FPRAGGGSGGSGSSGGLGPPGRPYGAIP--GQHVTLPRKTSSGSLPPPLSLFGARATSS- 1175 P+ GG+ G PPG+P G P G P PPP +R++ S Sbjct: 118 -PQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSRSSRSP 176 Query: 1176 ----GGPPLTAGPQREPGARPEPVRSKLP 1200 GPP G Q + G P P + + P Sbjct: 177 PGKPQGPPPQGGNQPQ-GPPPPPGKPQGP 204 Score = 34.3 bits (77), Expect = 0.73 Identities = 17/49 (34%), Positives = 22/49 (44%), Gaps = 1/49 (2%) Query: 134 EGDASPGEDRTPPGLAAEPERPGASAQPAASPPPPQQPPQPASASCEQP 182 +GD R+PPG P G + QP PPPP +P P +P Sbjct: 165 QGDNKSRSSRSPPGKPQGPPPQGGN-QPQGPPPPPGKPQGPPPQGGNKP 212 Score = 33.5 bits (75), Expect = 1.3 Identities = 17/49 (34%), Positives = 22/49 (44%), Gaps = 1/49 (2%) Query: 134 EGDASPGEDRTPPGLAAEPERPGASAQPAASPPPPQQPPQPASASCEQP 182 +GD R+PPG P G + QP PPPP +P P +P Sbjct: 227 QGDNKSQSARSPPGKPQGPPPQGGN-QPQGPPPPPGKPQGPPPQGGNKP 274 Score = 32.7 bits (73), Expect = 2.1 Identities = 16/49 (32%), Positives = 22/49 (44%), Gaps = 1/49 (2%) Query: 134 EGDASPGEDRTPPGLAAEPERPGASAQPAASPPPPQQPPQPASASCEQP 182 +G + R+PPG P G + QP PPPP +P P +P Sbjct: 289 QGGSKSRSSRSPPGKPQGPPPQGGN-QPQGPPPPPGKPQGPPPQGGNKP 336 Score = 32.7 bits (73), Expect = 2.1 Identities = 19/65 (29%), Positives = 26/65 (40%), Gaps = 6/65 (9%) Query: 134 EGDASPGEDRTPPGLAAEPERPGASAQPAASPPP------PQQPPQPASASCEQPSVDTA 187 +G PG+ + PP R S PP PQ PP PA + +QP A Sbjct: 337 QGPPPPGKPQGPPPQGGSKSRSARSPPGKPQGPPQQEGNNPQGPPPPAGGNPQQPQAPPA 396 Query: 188 IKVEG 192 + +G Sbjct: 397 GQPQG 401 Score = 32.0 bits (71), Expect = 3.6 Identities = 32/116 (27%), Positives = 41/116 (35%), Gaps = 7/116 (6%) Query: 1085 LISASQPALPQDGAQTLRRASPHSSGESMAAFPLFPRAGGGSGGSGSSGGLGPPGRPYGA 1144 LI S L AQ L S+ A P+ GG+ G PPG+P G Sbjct: 3 LILLSVALLALSSAQNLNEDVSQEESPSLIAGN--PQGAPPQGGNKPQGPPSPPGKPQGP 60 Query: 1145 IPGQHVTLPRKTSSGSLPPPLSLFGARATSSGGPPLTAGPQREPGARPEPVRSKLP 1200 P Q P+ G PPP G P P + G P+ +S+ P Sbjct: 61 -PPQGGNQPQ----GPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRSP 111 Score = 31.6 bits (70), Expect = 4.8 Identities = 18/49 (36%), Positives = 23/49 (46%), Gaps = 2/49 (4%) Query: 134 EGDASPGEDRTPPGLAAEPERPGASAQPAASPPPPQQPPQPASASCEQP 182 +GD S R+PPG P G + QP PPPP +P P +P Sbjct: 104 QGDKSRSP-RSPPGKPQGPPPQGGN-QPQGPPPPPGKPQGPPPQGGNKP 150 Score = 30.8 bits (68), Expect = 8.1 Identities = 16/49 (32%), Positives = 21/49 (42%), Gaps = 1/49 (2%) Query: 134 EGDASPGEDRTPPGLAAEPERPGASAQPAASPPPPQQPPQPASASCEQP 182 +G P +PPG P G + QP PPPP +P P +P Sbjct: 42 QGGNKPQGPPSPPGKPQGPPPQGGN-QPQGPPPPPGKPQGPPPQGGNKP 89 >gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens] Length = 855 Score = 82.0 bits (201), Expect = 3e-15 Identities = 126/469 (26%), Positives = 170/469 (36%), Gaps = 73/469 (15%) Query: 744 QIVQHDREMAHCAHRVQAAASATPTPTPVIWT---PLIQAPLQAAAATTSVAIALTHHPR 800 Q+ ++ A + ++ ATP+P+ + + P + A +++ T +A L P Sbjct: 284 QVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPP 343 Query: 801 LPAAIFRPPPGSGLGNLGAGQTPRHLKRLQSLIPSALGSASPASSPSQVDTPSSSSFHIQ 860 P+A PP L + A + L S A S P+ S + TP + Sbjct: 344 SPSA---PPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPAL 400 Query: 861 QLAGFSAPAGLSPLLPSSSSSPPPGACGSPSAPTPSAGVAATTIAGFGHFHKALGGSLSS 920 L AP PS +SPP +PS P+A A F Sbjct: 401 ALPPLQAP-------PSPPASPPLSPLATPSPQAPNALAVHLLQAPFS----------PP 443 Query: 921 SDSPLLTPLQPGAR---SPQAAQPSPAPPGARGGLGLPEHFLPP-PPSS--RSPSSSPG- 973 P+ P P A SP A PS APP L P +PP PP+S SPS++P Sbjct: 444 PSPPVQAPFSPPASPPVSPSATPPSQAPPS----LAAPPLQVPPSPPASPPMSPSATPPP 499 Query: 974 -----------QLGQPPGELSLGLATGPLSTPETPPRQPEPPSLVAGASGGASPVGFTPR 1022 QL +PP + LAT PL +PP + G +P F+P Sbjct: 500 QAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPP----------ASFPGQAP--FSPS 547 Query: 1023 GGLSPPGHSPGPPRTFPSAPPRASGSHGSLLLPPASSPPPP--QVPQRRGTPPLTPGRLT 1080 L P PP P APP + LL P S P P Q P+R TP Sbjct: 548 ASL-PMSPLATPP---PQAPPVLA---APLLQVPPSPPASPTLQAPRRPPTPGPDTSVSG 600 Query: 1081 QDLKLISASQPALPQDGAQTLRRASPHSSGESMAAFPLFPRAGGGSGGSGSSGGLGPPGR 1140 L L A P P + + + P +G S +A G G PP Sbjct: 601 PRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPP-- 658 Query: 1141 PYGAIPGQHVTLPRKTSSGSLPPPLSLFGARATSSGGPPLTAGPQREPG 1189 P + H P S G PPL+ GA PP T GP G Sbjct: 659 PDAELAACH---PAAWSRGP-APPLAFRGAPGAPLPWPPAT-GPGSADG 702 Score = 81.3 bits (199), Expect = 5e-15 Identities = 119/438 (27%), Positives = 157/438 (35%), Gaps = 72/438 (16%) Query: 807 RPPPGSGLG-NLGAGQTPRHLKRLQSLIPSAL--GSASPASSPSQVDTPSSSSFHIQQLA 863 RP P G + A +T K ++ SAL G+ S P+ TPS + + A Sbjct: 125 RPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTP-GTPSPAMARRSRAA 183 Query: 864 GFSAPAGLSPLLPSSSSSPPP-------GACGSPSAPTPSAGVAATTIAGFGHFHKALGG 916 G GL PS+ PP + S PS AG G + Sbjct: 184 G--TEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAG-GGLQRPASR 240 Query: 917 SLSSSDSPLLTPLQ--PGARSPQAAQPSPAPPGARGGLGLPEHFLPPPPSSRSPSSSPGQ 974 SLSSS +PL +P + P AR A P+ P +G L + PP +P+ P Sbjct: 241 SLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGP-- 298 Query: 975 LGQPPGELSLGLATGPLSTP--------ETPPRQPEPPSLVAGASGGASPVGFTPRGGLS 1026 L++ PL+TP + PP P P + A+P+ P + Sbjct: 299 -----------LSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSA 347 Query: 1027 PPGHS--PGPPRTFPS------APPRASGSHGSLLLPPAS--SPPPPQVPQRRGTPPL-- 1074 PP P PP T PS P +H L PP S + PPPQ P PPL Sbjct: 348 PPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQA 407 Query: 1075 -TPGRLTQDLKLISASQPALPQDGAQTLRRA--SPHSSGESMAAF------PLFPRAGGG 1125 + L ++ P P A L +A SP S A F P+ P A Sbjct: 408 PPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPP 467 Query: 1126 SGGSGSSGGLGPPGRPYGAIPGQHVTLPRKTSSGSLPPPLSLFGARATSSGGPPLTAG-- 1183 S S PP + + P P T PPPL+ PPL Sbjct: 468 SQAPPSLA--APPLQVPPSPPASPPMSPSATPPPQAPPPLA----------APPLQLAKP 515 Query: 1184 PQREPGARPEPVRSKLPS 1201 P + P A P LPS Sbjct: 516 PPQAPPALATPPLQALPS 533 Score = 57.0 bits (136), Expect = 1e-07 Identities = 114/443 (25%), Positives = 154/443 (34%), Gaps = 88/443 (19%) Query: 765 ATPTPT--PVIWTPLIQAPLQAAAATTSVAIALTHHPRLPAAI--------FRPPPGSGL 814 ATP P P + P +QAP A+ +A T P+ P A+ F PPP + Sbjct: 390 ATPPPQAPPALALPPLQAPPSPPASPPLSPLA-TPSPQAPNALAVHLLQAPFSPPPSPPV 448 Query: 815 GNLGAGQTPRHLKRLQSLIPSALGSASPASSPSQVDTPSSSSFHIQQLAGFSAPAGLSPL 874 Q P P A SP+++P PS ++ +Q A +SP Sbjct: 449 ------QAP--------FSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPS 494 Query: 875 LPSSSSSPPPGACG--SPSAPTPSAGVAATTIAGFGHFHKALGGSLSSSDSPLLTPLQPG 932 +PPP A + P P A A T +AL +S P P P Sbjct: 495 ATPPPQAPPPLAAPPLQLAKPPPQAPPALATPP-----LQALPSPPASF--PGQAPFSPS 547 Query: 933 ARSPQAAQPSPAPPGARGGLGLPEHFLPP-PPSS-------RSPSSSPGQLGQPPGELSL 984 A P + +P PP A L P +PP PP+S R P+ P P L+L Sbjct: 548 ASLPMSPLATP-PPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGP-RLTL 605 Query: 985 GLATGPLSTPETPPRQPEPPSLVAGASGGASPV-----GFT--PRGGL--SPP------- 1028 LA GP P P +AG S A+ G+ P GG SPP Sbjct: 606 ALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAA 665 Query: 1029 ------GHSPGPPRTFPSAP------PRASGSHGSLLL-------PPASSPPPPQVPQRR 1069 P PP F AP P A+G + L P S+ P P Sbjct: 666 CHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPG 725 Query: 1070 GTPPLTPGRLTQDLKLISASQPA-------LPQDGAQTLRRASPHSSGESMAAFPLFPRA 1122 +P + G+ ++S+ LP Q H ++ A Sbjct: 726 PSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQA--SVVQHLLSRTLLLAAAEGAA 783 Query: 1123 GGGSGGSGSSGGLGPPGRPYGAI 1145 GG GG G + G G G A+ Sbjct: 784 GGSGGGPGGAEGGGVTGGARAAL 806 Score = 50.1 bits (118), Expect = 1e-05 Identities = 84/322 (26%), Positives = 115/322 (35%), Gaps = 65/322 (20%) Query: 933 ARSPQAAQP---SPAPPGARGGLGLPEHFLPPPPSSRSPSSSPGQLGQPP---GELSLGL 986 AR+P A P +P PPG+ P P P++ + G +G+ P +G Sbjct: 14 ARTPAARAPGLLTPRPPGS------PRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGG 67 Query: 987 ATGPLSTPETPP--------RQPEPPSLVAGASGGASPVGFTPRGGLSPPGHSPGPPRTF 1038 AT P S P P R P +G A P T G +S PG + G R Sbjct: 68 ATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPG 127 Query: 1039 P--------------------SAPPRASGSHGSL--LLPPASSPPPPQVPQR---RGTPP 1073 P AP R++ S G+ P P P + +R GT Sbjct: 128 PLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEV 187 Query: 1074 LTPGRLTQDLKLISASQPALPQDG-AQTLRRASPHSSGESMAAFPLFPRAGGGSGGSGS- 1131 P + +++P P +G +++ AS HS+ E A P AGGG S Sbjct: 188 GLP-------RPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASR 240 Query: 1132 --SGGLGPPGRPYGAIPGQHVTLPRKTSSGSLPPPLSLFGARATSSGGPPLTAGP----- 1184 S P P + P T PR + S P P L R P A P Sbjct: 241 SLSSSATPLSSPARSGPSARGT-PRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPL 299 Query: 1185 QREPGARPEP---VRSKLPSNL 1203 P A P P ++S+ P L Sbjct: 300 SSSPLATPSPSAALQSQAPPTL 321 Score = 45.8 bits (107), Expect = 2e-04 Identities = 81/316 (25%), Positives = 109/316 (34%), Gaps = 70/316 (22%) Query: 925 LLTPLQPGARSPQAAQPSPAPP---------------------GARGGLGLPEHFLPPPP 963 LLTP PG+ P P P P G GG +PE P Sbjct: 24 LLTPRPPGSPRP----PPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGP 79 Query: 964 ------SSRSPSSSPGQLGQ----PPGELSLGLATGPLSTPETPPRQPEPPSL------- 1006 SSR+P+S P G+ PP + + GP+S+P P L Sbjct: 80 TRSAGTSSRNPASRPPASGRGERAPPAK---NTSPGPVSSPGRASGTTRPGPLGQKGLRI 136 Query: 1007 -----VAGASGGASPVGFTPRGGL--SPPGHSPGPPRTFPSAPPRASGSHGSLLLP-PAS 1058 VA +P G G +PG P + RA+G+ L P P++ Sbjct: 137 SAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSA 196 Query: 1059 SPPPPQVPQRRGTPPLTPGRLTQDLKLISASQPALPQDGAQTLRRASPHSSGESMAAFPL 1118 P PP R+ + T+ S + P G R P S S +A PL Sbjct: 197 RPRPPTEGPRKSVSSASEHSTTEP----SPAARRRPSAGGGLQR---PASRSLSSSATPL 249 Query: 1119 FPRAGGGSGGSGSSGGLGPPGRP----YGAIPGQHVTLPRKTSSGSLPP----PLSLFGA 1170 A G G+ P +P A+ VT PRK ++ +L P PL+ Sbjct: 250 SSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSP 309 Query: 1171 RAT--SSGGPPLTAGP 1184 A S P L A P Sbjct: 310 SAALQSQAPPTLPATP 325 Score = 38.5 bits (88), Expect = 0.039 Identities = 34/136 (25%), Positives = 51/136 (37%), Gaps = 10/136 (7%) Query: 26 MDEEEDAEEEGAGGRQDPSRRSIRLRPLPSPSPSAAAGGTESRSSALGAADSEGPARGAG 85 MD + D + GA R +R L P P SP T + LGAA + G A Sbjct: 1 MDNKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAE 60 Query: 86 KSSTNGDCRRFRGSLASLGSRGGGSGGTGSGSSHGHLHDSAEERRLIAEGDASPGEDRTP 145 ++ G ++ R G + G+ S + A R G+ +P T Sbjct: 61 RAGGIGG-----ATIPESAPRAGPTRSAGTSSRNPASRPPASGR-----GERAPPAKNTS 110 Query: 146 PGLAAEPERPGASAQP 161 PG + P R + +P Sbjct: 111 PGPVSSPGRASGTTRP 126 Score = 31.2 bits (69), Expect = 6.2 Identities = 18/39 (46%), Positives = 21/39 (53%), Gaps = 5/39 (12%) Query: 143 RTPPGLAAEPER--PGASAQPAASP---PPPQQPPQPAS 176 + PP LAA P + P A P SP PPPQ PP A+ Sbjct: 469 QAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAA 507 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.317 0.134 0.406 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 60,158,748 Number of Sequences: 37866 Number of extensions: 4097779 Number of successful extensions: 74405 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 427 Number of HSP's successfully gapped in prelim test: 2794 Number of HSP's that attempted gapping in prelim test: 30482 Number of HSP's gapped (non-prelim): 28364 length of query: 1203 length of database: 18,247,518 effective HSP length: 114 effective length of query: 1089 effective length of database: 13,930,794 effective search space: 15170634666 effective search space used: 15170634666 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.